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New directors possess diverse sets of experiences across drug development and corporate finance
WALTHAM, MA & MONTREAL, QC, December 7, 2021 – Ventus Therapeutics U.S., Inc., a biopharmaceutical company utilizing structural biology and cutting-edge computational tools to identify and develop small molecule therapeutics across a broad range of disease indications, today announced the appointments of Jane Henderson, Dolca Thomas, M.D. and Markus Warmuth, M.D. to the company’s Board of Directors.
“We believe the wealth of biopharmaceutical leadership and business expertise that Jane, Dolca and Markus bring to our Board of Directors will be instrumental as we continue to advance our pipeline and execute on our development strategy,” said Marcelo Bigal, MD, PhD, president and CEO of Ventus. “Jane is a veteran biopharmaceutical executive, a multiple-time CFO with significant expertise in corporate strategy and corporate finance. Dolca is a well-respected R&D leader and a multiple-time CMO with experience across a broad range of translational medicine, clinical development and medical affairs that drives innovative drug development. Markus brings extensive experience as a CEO and senior executive who has played a critical role in the building of emerging biotech companies and high-growth divisions of pharmaceutical companies. We welcome these three outstanding leaders to our team and look forward to their guidance as we work to build a leading-edge company.”
Jane Pritchett Henderson has served as Adagio Therapeutics’ Chief Financial Officer since December 2020. Ms. Henderson has a combination of corporate, board and investment banking experience growing public and private biopharmaceutical companies. Prior to joining Adagio Therapeutics, Ms. Henderson has held executive level roles in finance and corporate development at numerous biotechnology companies, including Turnstone Biologics, Voyager Therapeutics, Kolltan Pharmaceuticals (acquired by Celldex) and ISTA Pharmaceuticals (acquired by Bausch + Lomb). In addition to her industry experience, Ms. Henderson’s extensive healthcare investment banking experience includes the execution of more than 95 mergers and acquisitions, and advisory and financing deals as managing director and other senior roles at HSBC Holdings plc, Canadian Imperial Bank of Commerce, Lehman Brothers and Salomon Brothers. Ms. Henderson holds a B.S. in psychology from Duke University and currently serves on the board of directors of several companies including Akero Therapeutics, Inc. since April 2019, of IVERIC bio, Inc. since January 2018 and of Sesen Bio, Inc., formerly Eleven Biotherapeutics, Inc., since October 2013.
Dolca Thomas, M.D., is the Executive Vice President of Research and Development and Chief Medical Officer at Equillium and an independent director at Chinook Therapeutics. She served as Principia’s Chief Medical Officer from 2018 until the Sanofi acquisition in September 2020. Prior to Principia, Dr. Thomas was Vice President and Global Head of Translational Medicine for Immunology, Inflammation, and Infectious Disease at Roche; Vice President of Clinical Development and Clinical Immunophenotyping at Pfizer and Vice President and Chief Development Officer of the Biosimilars Research and Development Unit at Pfizer. Dr. Thomas began her industry career at Bristol-Myers Squibb as Director of Global Clinical Development, where she was involved in late stage clinical drug development including the approval of the immunomodulatory drug, belatacept. Dr. Thomas received a B.A. in sociology from Cornell University and an M.D. from Cornell Medical College.
Markus Warmuth, M.D., is the President, Chief Executive Officer and member of the board of directors at Monte Rosa Therapeutics. He joined Monte Rosa Therapeutics from Third Rock Ventures, where he was an Entrepreneur-in-Residence and played an integral role in the venture capital firm’s formation of new biotech companies. Prior to his role at Third Rock Ventures, Dr. Warmuth spent seven years as the Chief Executive Officer of H3 Biomedicine, a biopharmaceutical company that specializes in the discovery and development of genomics-based precision oncology treatments. He has also previously served in multiple roles at the Novartis Institutes for Biomedical Research and the Genomics Institute of the Novartis Research Foundation, including as the Director of Kinase Biology, Head of Oncology Pharmacology. While at Novartis, he and his teams were involved in the development of ceritinib and ribociclib as well as the discovery of allosteric inhibitors of SHP2 and Abl, amongst others. He also currently serves as a Venture Partner at Versant Ventures. He earned his M.D. from Ludwig Maximilian University, in Munich, Germany.
About Ventus Therapeutics
Ventus Therapeutics is a biopharmaceutical company utilizing structural biology and cutting-edge computational tools to identify and develop small molecule therapeutics across a broad range of disease indications, with an initial focus on immunology, inflammation and neurology. We have developed a proprietary drug discovery platform, called ReSOLVE, which is built upon our structural biology and protein science expertise and our proprietary computational chemistry capabilities, to address the current limitations of small molecule drug discovery. We are leveraging our ReSOLVE platform to discover and characterize previously unknown or poorly understood pockets on the surface of proteins and identify small molecules that can bind to those pockets with optimal affinity. We are focused on high-value targets that have been extensively implicated in human diseases that were previously considered undruggable or where we believe there is a significant opportunity to improve upon existing therapies. Our lead programs target key innate immune modulators, including NLRP3 and cGAS. For more information, please visit www.ventustx.com and engage with us on Twitter @Ventus_Tx or on LinkedIn.
The Yates Network


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Search America's historic newspaper pages from 1789-1924 or use the U.S. Newspaper Directory to find information about American newspapers published between 1690-present. Chronicling America is sponsored jointly by the National Endowment for the Humanities external link and the Library of Congress. Learn more
About The American Hebrew. online resource (New York, N.Y.) 1922-1932
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Began with: Vol. 110, no. 24 (Apr. 28, 1922); ceased with: Jan. 29, 1932.
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As the Golden State Warriors get set to debut a new roster in a new arena, their TV home NBC Sports Bay Area announced new additions for the upcoming season.
Less than a month away from their first regular season telecast, NBC Sports Bay Area added Chris Mullin, Jennifer Azzi and Brian Shaw to its roster of studio analysts. The trio will split time in the studio, also rotating as fill-ins for the broadcasts color commentator, Kelenna Azubuike.
NBC Sports Bay Area will televise 70 regular season games for the Warriors, along with three preseason contests. Longtime play-by-play announcer Bob Fitzgerald will be joined by former Warrior, Kelenna Azubuike as the broadcast’s new lead analyst. Azubuike joins the call after previously serving as a studio analyst on NBC Sports Bay Area, now replacing Fitzgerald’s longtime broadcast partner, Jim Barnett who moves to the Warriors flagship radio station, 95.7 The Game. Kerith Burke will return to NBC Sports Bay Area’s Warrior telecasts as the crew’s sideline reporter.
NBC Sports Bay Area has not announced a schedule for their new studio hosts, but former Warriors great and basketball Hall of Famer, Chris Mullin is expected to work all 41 home games. Mullin, who resigned as head coach of the St. John’s University men’s basketball team in the spring, has prior broadcast experience with ESPN.
“This will be a little different, I think. Obviously, you know, just really focusing on the Warriors,” Mullin told NBC Sports Bay Area about his previous ESPN experience compared to his new gig. “I’m kind of looking forward to really just locking in on the Warriors and just one opponent, as opposed to covering the whole league on a nightly basis. I think it’ll be a lot more fun.”
Former WNBA player, Jennifer Azzi brings an extensive resume to the network that includes an Olympic gold-medal, also previously serving as the head women’s basketball coach at the University of San Francisco. Also joining the NBC Sports Bay Area studio is Brian Shaw, a three-time NBA champion with the Lakers and more recently, the Denver Nuggets head coach from 2013 – 15.
NBC Sports Bay Area’s Warriors coverage will tip off on Saturday October 5th in their first preseason game.
Brandon Contes is a former reporter for BSM, now working for Awful Announcing. You can find him on Twitter @BrandonContes or reach him by email at email@example.com.
NFL Ratings on CBS Off to Best Start Since 2010
That number buoys the network to an average of 18.559 million viewers over the first four games of the season.
The NFL of CBS is behemoth to start the 2022 season. This past weekend saw the more massive ratings for the network.
Sunday’s national game window, which was led the Patriots-Packers overtime game, averaged 24.647 million viewers which was the most-watched Week 4 window on CBS since 1998, when the NFL returned to CBS. It’s also a ratings increase of 8% from last season.
That number buoys the network to an average of 18.559 million viewers over the first four games of the season, CBS‘ best start to a season since 2010.
ESPN Asked NHL For More Games on Linear TV
“It’s something that ESPN pushed for. But to the extent that ESPN was looking to make an adjustment for Year 2, we’re pleased to have the ongoing exposure.”
The 2021-2022 NHL season was the first of a new media rights deal that saw the league’s games air nationally on ESPN and TNT.
The 2022-2023 season will see more games on linear television, and NHL Commissioner Gary Bettman says that’s from ESPN’s insistence.
When asked by Sports Business Journal‘s Alex Silverman about a noticeably larger linear television schedule for the upcoming season, Bettman said “We’re happy to have it, but it’s something that ESPN pushed for. But to the extent that ESPN was looking to make an adjustment for Year 2, we’re pleased to have the ongoing exposure. Although, last year and the way things were balanced was a terrific year for us. Ratings were up, viewership was up, connectivity on all platforms for our fans was up. And ESPN and Turner have done an incredible job, and we’re grateful to be with them.”
Last season, ESPN and ABC only aired 28 games on linear television, 18 airing on ESPN or ESPN2 and 10 on ABC. 75 regular season games were exclusive to ESPN+ and Hulu.
This year, 52 games will air between the two networks with 37 games on ESPN or ESPN2 and 15 games on ABC. The Walt Disney Company has exclusive rights to 103 NHL broadcasts during the 2022-2023 season, including the opening night double header, the All-Star Skills Competition and All-Star Game, and the NHL Stadium Series.
FOX Ends MLB Regular Season Coverage With Highest Audience of Season
FOX reeled in 2,657,000 viewers for its two game slate (Rays-Astros or Mets-Braves).
FOX’s regular season coverage of MLB ended so strongly that it featured the best Saturday night baseball telecast on the network all season.
FOX reeled in 2,657,000 viewers for its two game slate (Rays-Astros or Mets-Braves). The Mets-Braves series was a battle of two teams trying to win the National League East division.


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London’s latest party concept which combines underground stars with sophisticated settings is back next month, bringing another industry hero in charge of proceedings. Set at the W Hotel in Leicester Square, the series which began back in September last year poses as a change of scenery from the usual dark, gritty atmosphere associated with the rave scene.
Put together by the much loved artist DJ Piem, who has a discography of high profile releases on labels such as Hot Since 82’s Knee Deep in Sound & Claude VonStroke’s Dirtybird Records. The new concept has since featured some huge names including Faithless, Roger Sanchez, Camelphat, and now welcomes Toolroom chief Mark Knight to centre stage.
The house music veteran is no stranger to playing in obscure venues, having travelled the world both on his own accord and with his esteemed record label; Toolroom. The powerhouse brand which celebrated their 10th anniversary last year has become a figurehead in the underground music realm, respected by artists, promoters and fans across the globe.
Mark himself has played a pivotal role in shaping the electronic music landscape as it stands today, both with the label and his own productions. Off the back of a recent tour which saw him feature all night long, Mark will land at W London on February 9th, no doubt armed with all the tools to make it a night to remember.
Tickets available here

domain: artistic


- — Evan Brandt (@PottstownNews)Thu, Jun 19 2014 23:45:48Pre-engineering and entrepreneurship and robotics among new classes being offered in #Pottstown High School says Bacallao.
- — Evan Brandt (@PottstownNews)Thu, Jun 19 2014 23:48:02Bacallao says district is staying on top of Math Excel program implementation. IMHO, there's still a ways to go judging from results.
- — John M. Black (@blackjohnm)Fri, Jun 20 2014 00:07:21@PottstownNews Is there really any other way to deliver a finance report? "Disembodied voice...now delivering finance rpt over speakerphone"
- Turns out, she was 15 minutes late and slipped in undetected by my razor-sharp reporter senses.
- — Evan Brandt (@PottstownNews)Fri, Jun 20 2014 00:10:18I think we have to be proud that we provide an education that is solid and equitable in an in-wealthy district, Zahora says.
Tax Hikes and Raises in Pottstown
Tweets from the June 19, 2014 meeting of the Pottstown School Board
byEvan Brandt530 Views


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Discounted Lasting Power of Attorney with The Planning Crowd
The Planning Crowd have partnered with Silversurfers to offer you a great discounts on Lasting Power of Attorney.
Lasting Power of Attorney (LPA)
- Safeguarding your wishes should accident or illness occur
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domain: law


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Are you lover of all things vintage? We’ve got the 411 on where you can shop for rare items you never knew even existed
TF001 3rd Floor, BB Plaza, Jalan Bukit Bintang
Tucked away in the quiet BB Plaza (next to Sungei Wang) is Buntil, a two-lot shop, which will appease the most seasoned of vintage collectors. Here, you will find a large collection of letterman jackets, vintage denim jackets, jeans and an impressive lot of official concert tour tshirts from the likes of Queen (RM689), Bruce Springsteen & The E Street Band (RM689) and Michael Jackson’s notable Beat It Tour (RM500).
With 15 years of experience under his belt, owner Lan (photographed in feature image) usually buys his bundles from Thailand. A bit like US reality series Storage Wars, the contents of the bundle are unknown until after the purchase. “When you buy a bundle. You don’t know what’s inside. The stuff you get is collected from US, Japan and around Asia,” he explains. And what was the most valuable bundle purchase he’s ever made? “It was a bundle with an original Levis jacket from 1947 worth RM7000.”
Lot 24, Level G2, Publika, Jalan Dutamas 1, Solaris Dutamas
At first glance, Hariz Vintage looks like an assuming furniture shop, stocked with wooden furniture, however, upon closer inspection, you’ll find a collection of national treasures from a framed jacket worn by the young prince of Nusantara to old official press photographs and locally printed magazines you never knew existed.
Walking through the store, you almost feel like you’re being treated to a history lesson in Malaysian heritage. But don’t get me wrong; the shop also has its fair share of western memorabilia – an old LIFE Magazine with the legendary Winston Churchill as its cover boy, Daily Mirror newspapers from the late 1940s and records from the 60ss and 70s are just some of its incredible memorabilia up for sale – worth a visit for both collectors and inquisitive minds alike.
Yes, its true that brick and mortar stores allow for the touch-and-feel factor but mobile marketplace apps are on-the-go, which ultimately bring that fleamarket thrifting experience to the palm of your hand. Enter, Duriana. A new social selling app which leverages all kinds of vintage sellers, connecting likeminded collectors on one platform. A simple search of ‘vintage’ which allow you to discover a world of rare items from an old vintage Yashica camera to eclectic collection of rare toys.

domain: hobby


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Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients
Journal of Translational Medicine volume 19, Article number: 388 (2021)
Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with a median age of 68 in clinical diagnosis. About 60% patients are over 60 years old. There are various treatment options for AML patients. But for elderly patients, the complete remission rates are disappointing due to genetic, molecular, and age-related factors. Development of next-generation sequencing technologies makes it possible to seek individual strategies for patients in different ages. This study analyzed transcriptome profiles in platelets of AML patients in different ages for the first time.
Platelet RNA sequencing in AML of ten elderly and seven young patients were performed with Illumina TruSeq Stranded mRNA library Prep Kit and Illumina HiSeq4000 sequencing instrument. With the FASTQ sequencing data obtained, statistical analyses between elderly with young AML patients were analyzed by R program. GO and KEGG enrichment analyses were performed via R package clusterProfiler. TOP 10 down-regulated/up-regulated genes in elderly patients compared to young patients were selected with the threshold of |L2FC| > 2 and padj ≤ 0.0001. The down-regulated gene ATF4 was chosen by GSEA analysis and ROC analysis with AUC > 0.95.
We found 3059 genes with differential transcript levels (GDTLs) in AML patients of different age. Among them, 2048 genes are down-regulated and 651 genes are up-regulated in elderly patients. We found that gene transcript profiles in elderly patients is obviously different from those in young patients, including a collection of down-regulated genes related to proteins processing in endoplasmic reticulum and immunity. We further identified that genes of pathway in cancer and mitogen activated protein kinase (MAPK) pathway, involved in natural immunity and metabolism, are significantly down-regulated in elderly patients. Among all screened genes with decreased transcript levels, we believe that activating transcription factor 4 (ATF4) is a biomarker indicating different chemotherapy strategies for elderly patients.
In summary, gene transcript profiles are different in platelets of elderly and young AML patients. And ATF4 can be a useful biomarker indicating different chemotherapy strategies for AML patients with different ages.
Gene transcript profiles in the elderly AML patients are different from those in young patients.
Statistical analysis reveals the down-regulation of protein processing in ER and pathways related to immunity in elderly patients.
GEO and GSEA analyses demonstrate the genes of cancer pathway and mitogen activated protein kinase (MAPK) pathway, involved in natural immunity and metabolism, are largely down-regulated in elderly patients.
ATF4 is a biomarker indicating different therapeutic strategies for elderly patients.
Acute myeloid leukemia (AML), as the most common acute leukemia in adults, is a malignant cancer characterized by abnormally differentiated and proliferated hematopoietic stem cells infiltrating bone marrow, blood and other tissues . The general therapeutic strategies for AML patients changed little for many years, with a combination of consolidation therapy of hematopoietic-cell transplantation and conventional chemotherapy following cytarabine or anthracycline induction for complete remission [2, 3]. Several problems arise since the median age of AML patients is 68 years old . Current clinical data show a cure rate of 35% to 40% in AML patients who are 60 years of age or younger, but less than 15% in patients over 60 years old [2, 4]. Along with high risk of relapse, the approximate survival of elderly patients is only 5 to 10 months.
The heterogeneity of AML accounts for the generally low cure rate for patients. Specially, a collection of various adverse prognostic factors and comorbidities of elderly patients is the determining limitation in chemotherapy and hematopoietic-cell transplantation . Although a study reported autologous hematopoietic stem cell transplantation (HCT) to be a considerable strategy with distinct anti-leukemic effectiveness for elderly patients, the outcome of elderly patients is still disappointing . In recent years, the development of RNA sequencing over microarray has made it possible to analyze the karyotype of AML patients, thereby providing different treatment measures to patients with different subtypes [7,8,9]. There are several studies analyzing the genes with differential transcript levels of AML patients. Genes such as DNMT3A, NPM1 and CEBP1 are proved to be alternatively regulated in AML patents [10,11,12]. These biomarkers contribute to a better understanding of AML and make great sense in diagnosis and prognosis for patients .
With the development of technologies, there is a better understanding for important roles of transcripts in platelets in pathophysiology . Although many studies have analyzed the changes in the transcript profiles of AML patients, studies of platelet RNA sequencing on AML patients are limited. Besides, the differences in gene transcript profiles between elderly and young AML patients have yet to be analyzed.
In this study, we analyzed the difference in gene transcript profiles between young and elderly patients. We obtained 17 blood samples from AML patients in Shanghai Yueyang Integrated Traditional Chinese Medicine and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine, and characterized them to two different groups according to age. 10 samples from AML patients over 60 years old are classified to elderly group, and 7 samples left belong to young group. After RNA sequencing in platelets, the following statistical analysis identifies 3059 genes with differential transcript levels in AML patients of different age, with 2408 genes down-regulated and 651 genes up-regulated in elderly patients, suggesting that gene transcript profiles in elderly patients is obviously different from that in young patients. Besides the global down-regulation gene profile, gene transcript profiles related to protein processing in endoplasmic reticulum and immunity are notably impaired in elderly patients, which explains the disappointing outcome of elderly AML patients.
We further reveal that genes of pathway in cancer and mitogen activated protein kinase (MAPK) pathway, involved in natural immunity and metabolism, are significantly down-regulated in elderly patients. Combined with the top ten down-regulated genes selected with the threshold of |Log2FC| > 2 and padj ≤ 0.0001, we identify the down-regulated gene, activating transcription factor 4 (ATF4) is a biomarker indicating potential therapeutic strategies for elderly patients.
Sample collection and purification
Blood samples of eleven elderly and eight young AML patients were collected from AML patients in Shanghai Yueyang Integrated Traditional Chinese Medicine and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine from February 7 2018 to March 14 2019. In accordance with Declaration of Helsinki, this study was approved by the Ethical Committee of the Yueyang Hospital. And written informed consent was obtained from all subjects and/or guardians for the use of their blood samples.
RNA extraction qualification
Platelets isolations were performed as reported . For RNA sequencing analysis, total RNA was purified with TRIzol reagent (Invitrogen) treatment. After RNA extraction, The RNA quality was measured by the following ways: (a) Agarose gel electrophoresis for integrity and DNA pollution of the RNA; (b) NanoPhotometer spectrophotometer for the RNA purity (the results of OD260/280 and OD260/230); (c) Qubit2.0 Fluorometer for the exact RNA concentration; and (d) Agilent 2100 bioanalyzer for quantitative analysis of RNA integrity.
Library construction and sequencing
Total platelet RNA of each sample was extracted using RNeasy Micro Kit (Qlagen, cat. no. 74004) per the manufacturer’s instructions. The total RNA was quantified and qualified by Agilent 2100 Bioanalyzer, NanoDrop (Thermo Scientific) and 1% agrose gel. Reverse transcription was achieved with 1 ng of total RNA, oligo (dT) primer and Superscript II reverse transcriptase. To have sufficient platelet cDNA for robust RNA-seq library preparation, each sample was subjected to 20-cycle enrichment PCR, using the KAPA HiFi HotStart ReadyMix PCR kit (Kapa Biosystems, USA), yielding ~ 200 ng of cDNA. The cDNA fragments around 200 bp were then purified with AMPure XP beads, which were amplified by PCR. The purified cDNA library was purified with AMPure XP beads. Then, Qubit2.0 Fluorometer was used to measure the DNA concentration and library dilution, and Agilent 2100 bioanalyzer was used to test the insert size of the library. And qRT-PCR was performed to test the library effective concentration precisely (> 2 nM effective concentration). Next paired-end sequencing was performed by the Illumina HiSeq4000 sequencing instrument, according to the manufacturer’s instructions and as reported .
Quality control was performed after the FASTQ sequencing data obtained with fastp software (https://github.com/OpenGene/fastp) to remove over-short, low-quality, undetected and also the adaptor reads. Mapping step was performed with STAR software, an ultrafast universal RNA-seq aligner, using MMP (Maximal Mappable Prefix) method to align the RNA-seq data onto the hg19 reference genome . HTSeq (https://pypi.org/project/HTSeq/) was then used for gene transcript quantification. Gene transcript profiles were analyzed by R program and related packages. Pathway analyses were performed with Gene Ontology (GO) (http://www.geneontology.org) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database (http://www.genome.jp/kegg/). Venn diagram of down-regulated genes in elderly patients compared to existing GSE13888 database was obtained by the interactive Venn diagram viewer jvenn (http://jvenn.toulouse.inra.fr/app/index.html) . Statistical significance of data was assessed by one-way ANOVA test.
Comparison of gene transcript profiles between young and elderly AML patients
In this study, we collected 19 blood samples from AML patients admitted to Shanghai Yueyang Integrated Traditional Chinese Medicine and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine, and characterized them to two different groups according to age (Fig. 1A). AML patients over 60 years old are classified to elderly group, the others belong to young group . Following platelets and RNA isolation, we performed platelet RNA sequencing and obtained the raw FASTQ data. After scanning, probe-level data were preprocessed, including background correction, quantile normalization and summarization (Additional file 1: Table S1). Sample AML003 was excluded due to the low quality of RNA sequencing data. The RNA sequencing data of sample AML017 was excluded for following analyses as requested by this patient. Thus, we got 10 sequencing results for elderly patients and 7 for the young.
By analyzing the expression data of the two groups with R program, we screened GDTLs between elderly and young group with the threshold of |Log2FC| > 2 and P_value ≤ 0.05. As shown in the volcano plot, a total of 3059 GDTLs were screened, among which 651 (21.28%) genes were up-regulated and 2408 (78.72%) genes were down-regulated in the elderly group compared to the young group, suggesting a primary downward trend of gene transcript profile in elderly AML patients (Fig. 1B, C, Additional file 2: Table S2).
To further understand conversation and variation of GDTLs at the level of organisms between elderly and young group, we performed KEGG pathway enrichment analyses to functionally annotate GDTLs via the R package clusterProfiler (Additional file 3: Table S3). KEGG is a database resource that integrates genomic, chemical and systemic functional information . Results showed that up-regulated genes in elderly group were mainly enriched in pathways such as ECM-receptor interaction, focal adhesion and retrograde endocannabinoid signaling, and down-regulated genes were mainly enriched related to proteins processing in endoplasmic reticulum and immunity (Fig. 1D, E),
Protein–protein interactions (PPI) and GO analysis of down-regulated genes in elderly group
Given that gene transcript profiles in the elderly group were mainly down-regulated, we speculated down-regulated genes were of great importance for different outcomes in AML patients of different ages. To construct a protein–protein interactions (PPI) network, we analyzed up-regulated genes in elderly group with the threshold of |Log2FC| > 2 and padj ≤ 0.00001, and found that they co-expressed or co-localized but rarely involved in a common pathway (Fig. 2A). On the contrary, the down-regulated genes selected with the same criterions had more tight connections in genetic and physical pathways (Fig. 2B). The difference reminds us that down-regulated genes in elderly group compared to the young group could be the biomarkers indicating different therapeutic strategies in clinic.
We next performed GO analysis to further annotate the biological roles of down-regulated genes, including biological process (BP), cellular component (CC) and molecular function (MF) (Additional file 4: Table S4). The top 4 GO terms related to biological process of the down-regulated genes in elderly group were neutrophil degranulation, neutrophil activation involved in immune response, neutrophil activation and neutrophil mediated immunity (Fig. 3A). In line with KEGG analyses, since AML patients suffer hematopoietic stem cells differentiating and proliferating abnormally, which impairs the immune system, the RNA sequencing based on platelets in this study is quite reliable. Meanwhile, the top 4 cellular component terms related to pathways of granule metabolism (Fig. 3B). Notably, the top molecular function term was oxidoreductase activity (Fig. 3C), suggesting that certain pathways of metabolism changed greatly in elderly patients.
ATF4 and STAT5B are biomarkers indicating potential therapeutic strategies for elderly patients
Gene Set Enrichment Analysis (GSEA) was applied subsequently to extract biological insights into these down-regulated genes sharing common biological processes . Based on GSEA, there were 183 down-regulated mixing pathways in the elderly group (Additional file 5: Table S5). We noticed that the top 3 terms were cytokine-cytokine receptor interaction, MAPK signaling pathway and pathways in cancer (Fig. 4A). MAPK pathway regulates various cellular processes including proliferation and differentiation , which suggests the genes involved in MAPK pathway may be of significance for AML therapy.
To identify worthwhile genes, we screened 32 genes down-regulated in the elderly group with the threshold of |Log2FC| > 2 and padj ≤ 0.00001, with the heatmap plot showing obvious differential transcript levels (Fig. 4B). We further selected the top 10 genes, PRDX6, STMP1, ATF4, PTPN18, CDKN2D, RAB11A, DNM2, CRAT, SPARC, STAT5B, compared the expression levels and confirmed the variations between elderly and young group (Fig. 5A). Through a cross-comparison of the gene sets in MAPK pathway with these 10 genes, we found ATF4 could be a potential biomarker indicating the different outcomes between elderly and young AML patients. To confirm our speculation, we performed ROC analysis and found that the AUC score of ATF4 is extremely high (AUG = 0.95), indicating that ATF4 is more reliable to be a biomarker than other 9 genes (Fig. 5B). We further screened 394 different expressing genes between young and elderly AML samples from TCAG database (https://portal.gdc.cancer.gov) with |log2fc| > 1 and padj ≤ 0.05, and compared the result with our study. Unexpectedly, even though there were 77 genes screened coincident with our results, ATF4 is not among them (Fig. 5C). To confirm our RNA-sequencing results, we performed qPCR as well as western blotting analysis to detect mRNA and protein levels in young and old AML patients. These results revealed that the expression level of ATF4 is much higher in young patients compared to the elderly (Fig. 5D, E). Since up-regulation of ATF4 was reported to promote hematopoietic stem cells (HSCs) survival, we thus identified the transcription factor ATF4 to be an important biomarker guiding the different strategies for AML therapy in elderly patients.
Despite the rapid development of technologies over the past few decades, the therapeutic strategies for AML patients changed little . And there are many analyses in molecular level classifying AML to certain subtypes, but no widely accepted algorithm provides therapeutic guidelines for elderly patients. In this study, using a combination of platelet RNA sequencing and bioinformatic analyses, we analyzed the GDTLs between elderly and young AML patients for the first time, and find a global down-regulation pattern in elder AML patients.
As the anucleate cells, platelets used to be considered irrelevant to transcription until studies detected RNAs in platelets . Transcripts in platelets thus became the resourceful measures in blood-based diagnostic tests . RNA-Seq of tumor-educated platelets (TEPs) has enabled blood-based cancer diagnostics and indicate potential clinical therapies . We sequenced the platelets RNA for the blood cancer, AML. By analyzing transcripts, we confirm the fact that the biological pathways related to immunity in elderly patients were quite different from young patients. Further GSEA analysis reveals that down-regulated gene sets of elderly patients are enriched in MAPK pathway.
Taking into account that MAPK pathway plays an important role in cell proliferation and differentiation as mentioned, we believe that MAPK pathway contributes to the pathological process in AML . With the extensive studies of MAPK cascades, MAPK pathway is believed to take part in cancer development and progression . And drugs based on MAPK pathway have been used in cancer therapies . Combined with our analysis results, we identified a transcription factor ATF4, is down-regulated markedly in elderly patients compared to the young.
ATF4 is one of the main regulators in cellular stress response related to ER . And a previous study has shed light on the relationship of ATF4 with AML, which clarifies that targeting autophagy or ATF4 in patients expressing FLT3 mutations may represent a novel promising and innovative therapeutic strategy for AML . This study provides the possibility that ATF4 not only mediates autophagy in FLT3-mutated AML patients, but also plays a key role in cell proliferation and differentiation mediated by MAPK pathway. The characteristics of elderly AML patients with low ATF4 level are different from the young patients. As more and more evidences show that the identification of new AML biomarkers contributes to a better understanding of the molecular basis of the disease, we hope that ATF4, as a biomarker and the potential therapeutic target, will be significantly useful in diagnosis and prognosis for elderly AML patients, as well as the possibility of indicating new therapeutic strategies [13, 30].
Availability of data and materials
The datasets used and analyzed during the current study are available in the public database https://www.ncbi.nlm.nih.gov/bioproject/PRJNA722042. Accession number: PRJNA722042. Other materials are available from the corresponding author on reasonable request.
Döhner H, Weisdorf DJ, Bloomfield CD. Acute myeloid leukemia. N Engl J Med. 2015;373(12):1136–52.
Döhner H, Estey EH, Amadori S, Applbaum FR, Büchner T, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115(3):453–74.
Roberts D, Langston AA, Heffner LT. Acute myeloid leukemia in young adults: does everyone need a transplant? J Oncol Pract. 2019;15(6):315–20.
Bethesda. SEER cancer stat facts: acute myeloid leukemia. National Cancer Institute. https://seer.cancer.gov/statfacts/html/amyl.html. Accessed 22 Dec 2020.
Ossenkoppele G, Löwenberg B. How I treat the older patient with acute myeloid leukemia. Blood. 2015;125(5):767–74.
Mueller B, Seipel K, Bacher U, Pabst T. Autologous transplantation for older adults with AML. Cancers. 2018;10(9):340.
Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B. Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods. 2008;5(7):621–8.
Montgomery SB, Sammeth M, Gutierrez-Arcelus M, Lach RP, Ingle C, et al. Transcriptome genetics using second generation sequencing in a Caucasian population. Nature. 2010;464(7289):773–7.
Reddy OL, Savani B, Stroncek DF, Panch SR. Advances in gene therapy for hematologic disease and considerations for transfusion medicine. Semin Hematol. 2020;57:83–91.
Marková J, Michková P, Burčková K, Březinová J, Michalová K, et al. Prognostic impact of DNMT3A mutations in patients with intermediate cytogenetic risk profile acute myeloid leukemia. Eur J Haematol. 2012;88(2):128–35.
Boissel N, Renneville A, Biggio V, Philippe N, Thomas X, et al. Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype. Blood. 2005;106(10):3618–20.
Fröhling S, Schlenk RF, Stolze I, Bihlmayr J, Benner A, et al. CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol. 2004;22(4):624–33.
Prada-Arismendy J, Arroyave JC, Röthlisberger S. Molecular biomarkers in acute myeloid leukemia. Blood Rev. 2017;31(1):63–76.
Eicher JD, Wakabayashi Y, Vitseva O, Esa N, Yang Y, Zhu J, et al. Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction. Platelets. 2016;27(3):230–9.
Jeon SA, Park JL, Kim JH, Kim JH, Kim YS, et al. Comparison of the MGISEQ-2000 and Illumina HiSeq 4000 sequencing platforms for RNA sequencing. Genom Inform. 2019;17(3):e32.
Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29(1):15–21.
Bardou P, Mariette J, Escudié F, Djemiel C, Klopp C. jvenn: an interactive Venn diagram viewer. BMC Bioinform. 2014;15(1):1–7.
Oriol A, Ribera JM, Esteve J, Guardia R, Brunet S, et al. Feasibility and results of autologous stem cell transplantation in de novo acute myeloid leukemia in patients over 60 years old. Results of the CETLAM AML-99 protocol. Haematologica. 2004;89(7):791–800.
Kanehisa M, Goto S, Sato Y, Furumichi M, Tanabe M. KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 2012;40(D1):D109–14.
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102(43):15545–50.
Keshet Y, Seger R. The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions. MAP Kinase Signal Protoc. 2010;661:3–38.
Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P, et al. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med. 2016;374(23):2209–21.
Rowley JW, Schwertz H, Weyrich AS. Platelet mRNA: the meaning behind the message. Curr Opin Hematol. 2012;19(5):385–91.
Best MG, In’t Veld SGJG, Sol N, Wurdinger T. RNA sequencing and swarm intelligence-enhanced classification algorithm development for blood-based disease diagnostics using spliced blood platelet RNA. Nat Protoc. 2019;14(4):1206–34.
Best MG, Sol N, Kooi I, Tannous J, Westerman BA, et al. RNA-Seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics. Cancer Cell. 2015;28(5):666–76.
Guo YJ, Pan WW, Liu SB, Shen ZF, Xu Y, et al. ERK/MAPK signalling pathway and tumorigenesis. Exp Ther Med. 2020;19(3):1997–2007.
Lu M, Wang Y, Zhan X. The MAPK pathway-based drug therapeutic targets in pituitary adenomas. Front Endocrinol. 2019;10:330.
Wortel IMN, van der Meer LT, Kilberg MS, van Leeuwen FN. Surviving stress: modulation of ATF4-mediated stress responses in normal and malignant cells. Trends Endocrinol Metab. 2017;28(11):794–806.
Heydt Q, Larrue C, Saland E, Bertoli S, Sarry JE, et al. Oncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia. Oncogene. 2018;37(6):787–97.
Li X, Sun WJ, Li ZJ, Zhao YZ, Li YT, et al. A survival study and prognostic factors analysis on acute promyelocytic leukemia at a single center. Leuk Res. 2007;31(6):765–71.
We appreciated Fun-med Pharmaceutical Technology (Shanghai) Co., Ltd. for technical supports.
This study was supported by the funds from the National Natural Science Foundation of China (81774258), Clinical Talents Program for Peak Plateau Discipline of Shanghai University of Traditional Chinese Medicine, Three-year Plan of Action for Traditional Chinese Medicine in Shanghai (ZY(2018-2020)-CCCX-2004-09), Program of Shanghai Education Commission (2019WK122), Subsidy Scheme for Promoting Teaching Ability of Young and Middle-aged Key Teachers of Shanghai University of Traditional Chinese Medicine, Xinglin Inherit-patterned talents Program of Shanghai University of Traditional Chinese Medicine and Shanghai's three-year action plan to further accelerate the development of traditional Chinese Medicine - key specialty cultivation project - hematology specialty, (B01B1 hematology specialty).
Ethics approval and consent to participate
This study was approved by the Ethical Committee of the Yueyang Hospital, in accordance with the 1964 Helsinki declaration. Written informed consent was obtained from all participants. The approval number from the ethical committee is 2020-172.
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Xinhua Zhao is co-first author
Quality control details of platelet RNA-seq.
Differential transcript levels of genes in platelets between young and elderly AML patients.
KEGG pathway enrichment analysis results.
GO enrichment analysis results of genes with downward transcript levels.
GSEA enrichment analysis results.
About this article
Cite this article
Bao, J., Zhao, X., Lu, J. et al. Platelet transcriptome profiles provide potential therapeutic targets for elderly acute myelocytic leukemia patients. J Transl Med 19, 388 (2021). https://doi.org/10.1186/s12967-021-03041-8
- Acute myeloid leukemia
- Platelet RNA sequencing
- Mitogen activated protein kinase
- Activating transcription factor 4

domain: health


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Jewels Blitz is the ultimate match-3 puzzle game! It’s your objective to combine at least three precious gems of the same type to make them vanish and score points. If you match even more jewels you get cool boosters that can clear complete lines, squares or remove all gems of the same color. Don’t rush your moves and always keep an eye on your score as the turn limit is challenging and sometimes you need to plan a few moves ahead. Whether it is on your phone, your tablet or on a desktop computer, you can play Jewels Blitz everywhere and every time. Play Jewels Blitz now for free and make your way through tons of fun and challenging levels!
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domain: game


I have two sync modules. They are named Blink Indoor Sync and Blink Outdoor Sync in my list of router devices. I have two XT cameras connected to my outdoors sync and three (2 are XT) connected to the other sync device.
I note though that my WiFi network shows ADDITIONAL devices (so far three) attached to my router which appear to be related to Blink. They appear and disappear aparently randomly. They are entitled XXXXXX-mysimplelink where XXXXXX is a long hexadecimal number.
They are not an external device connecting to my Network which is secure.
They only appeared when I installed Blink.
Mac address says they are built in to a device manufactured by Texas Instruments and is used by, from Google searches, DoorChime systems developed by Blink competitors as a for instance.
It is also integrated in to Amazon Web Systems. I quote from the link below:
“Enabling developers to quickly and securely connect Internet of Things (IoT) endpoints to the cloud, Texas Instruments (TI) (NASDAQ: TXN) today announced the integration of the new Amazon FreeRTOS into the SimpleLink™ microcontroller (MCU) platform. Amazon Web Services (AWS) has worked with TI in the development of an integrated hardware and software solution that enables developers to quickly establish a connection to AWS IoT service out-of-the-box and immediately begin system development.”
and as Blink is an Amazon device I think it is highly likely that it is in Blinks systems.
Blink Technical Support are next to useless - They seem to google when they run out of Template answers or quote my info back to me.
Any idea what these devices are and what purpose they perform?


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I just finished this drama a few days ago and decided to share my thoughts on it. It took me a while because I stopped in the middle after getting so busy that I couldn’t really make time for it anymore.
Starring Megan Lai and Roy Qiu, I thought that this drama was funny and quirky. A little refreshing, actually, because it wasn’t quite the same as all those typical rom-coms floating around among Taiwanese dramas.
The leads had nice chemistry and the characters weren’t too flat or boring. The lack of second-male lead syndrome helped, too. Actually, that little bit with the second-male lead near the end sort of threw me for a loop.
It got pretty boring around the middle, but picked up near the end, as a lot of dramas do. I actually posted about this a little while ago, but I’m glad that I finished it. The ending was sort of a little like redemption for the whole drama.
Perhaps the little (Read: Long) break that I took from watching the drama helped with that a little bit, who knows.
However, unlike many of the dramas that I’ve watched, the ending didn’t disappoint me. Usually, when I like dramas at the beginning, I find the endings sorely disappointing. This wasn’t the case this time, though.
Well…now to move on to my next drama, I guess.
So…I’m currently watching this Taiwanese drama called “Miss Rose”…that is, I’m totally stuck on episode 18 of 23. It’s not because I’m confused or whatever, but…it’s because the drama has gotten so boring that I don’t want to watch anymore.
This is where the problem comes in: I have this thing about finishing whatever I start (Dramas, songs, dances, etc.), so I can’t just leave it. But the plot has gotten pretty slow and I have no emotional investment so I don’t really care what happens to the characters anymore.
This was really cute, funny and entertaining at first, and I thought it would be a really good drama…but, like with most dramas that start off strong, they’re usually a let-down by the end. I found the idea of the drama cute and the chemistry between the two characters is pretty good (And, for once, I don’t have that annoying second-male lead syndrome…I actually sort of hate the second male lead)…it’s just the writers, dragging the plot on.
Well…I guess I’ll just finish this one off (I’ve been saying this for a month now). Luckily, I have “A Hundred Year Legacy” to keep me entertained, too (It’s on TV once a week…the two leads are just adorable together! Also no second-male lead syndrome…enjoying my break from that! Strangely enough, I dislike most of the characters, but still enjoy the drama, and I am totally rooting for the main couple…but that’s another story entirely).
Funny side note: This drama has been classified as a Korean Drama on some websites, which I don’t understand because it’s in Taiwanese and shot in Taiwan with Taiwanese actors/actresses…


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Richard Speakman has finished harvest at Sandon Lodge Farm, Chelmsford, Essex, and is well underway with drilling next year’s oilseed rape.
“We finished on 31 August, which was later than usual for us,” he said.
Cassia winter barley yielded 8.2t/ha, coming off at 16% moisture with a 74kg/hl bushel weight. “It was an exceptional crop and a huge improvement on last year.”
Winter oilseed rape was disappointing in comparison to previous years, yielding an average of 2.9-3t/ha and coming off the field between 7.5% and 15% moisture.
Winter wheat was very variable, with the early sown crops exceeding the usual farm average, but those drilled in wet conditions proving very poor, said Mr Speakman.
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Bushel weights were all above 80kg/hl and the wheat came off at 12-20% moisture.
“We haven’t really reduced drier costs as we’ve been out in the combines pushing hard early in the mornings,” he added.
Mr Speakman had now drilled the 360ha of oilseed rape for next year, and sprayed and fertilised it. “A good drop of rain will do everything the world of good for us now.”
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domain: news


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I have so many mixed emotions when it comes to Mariano Rivera and his pending retirement. I’m a lifelong Yankee fan whose first nickname, even before Gambo, was ‘Yankee’ in the St. Gerard’s Little League. I’ve been to hundreds of games at Yankee Stadium. I have wrappers that I have saved from Reggie Bars — don’t ask. I have scrapbooks from the ’77 and ’78 seasons. I know who Brian Doyle is!
Okay, I made my point, I love my team. And as a lifelong baseball fan, I’ve seen all the greats get old and lose it — from superstars to average ball players. I saw Willie Mays at the end with the Mets and Steve Carlton with the Twins. I watched Tom Seaver with the Red Sox, Joe Morgan with the Phillies and A’s and even recently Randy Johnson with the Giants. It’s the law of nature: you get old, your skills diminish, and if you hang around, you become a shell of your former self.
But Rivera defied those odds. He was great from start to finish. The best at his position year after year for parts of three decades. Even now at the age of 43 there isn’t a manager in baseball that would choose anyone other than Rivera to close a game they had to win.
Rivera is baseball royalty. Everyone watching knows we will never see anyone like him ever again, it’s just not possible. No need to go over the statistics, he’s the best and there is no argument. It can’t be debated and no one would dare try.
And while I would love to see him continue to pitch I’m happy to see him go out on top. Not like Jim Brown, Sandy Koufax and Barry Sanders who all retired early. But for someone whose been doing this since 1995. I’ll be very happy to say I never saw Rivera have a bad season. I never saw him get old. I never saw him ordinary. Never saw his skills diminish. All I saw was greatness from start to finish.

domain: sports


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Fearing that the establishment of a monkey park near human habitation may trigger diseases similar to Kyasanur Forest Disease (KFD), the residents of Nittur Gram Panchayat in Hosanagar taluk have opposed it and plan to resist if the government does not drop its plan.
The State government recently passed an order on establishing a monkey park in Shivamogga district to address the monkey menace. Following this, a team of officials from Revenue and Survey, Settlements and Land Records departments conducted a survey at Nagodi village in Nittur GP limits for establishing the park there. The team found 150 acres of unused government land at Survey Number 305 near Nagodi suitable for the proposed park.
The residents expressed apprehension about the park at a special Gram Sabha of Nittur GP last Friday. Srikanth, a farmer from Nagodi, told The Hindu that the place identified for the monkey park was 500 metres from the closest human settlement. As the villages here are in the forest fringe area, and are thereby vulnerable to KFD, a viral infection transmitted from monkeys to humans through tick bite, there is fear that establishing a monkey park will make them more susceptible to the disease. They also fear that apart from KFD, other infections may spread with the confinement of a large number of monkeys near human dwellings. In 2018-19, 12 persons died owing to KFD in Shivamogga district. As many as 341 KFD cases were reported there during this period.
Subrahmanya Bhat, a farmer from Nagodi, said that though the locals are not opposed to the idea of a monkey park, because they have suffered heavy losses owing to primates raiding their crops frequently, they do not want a monkey park set up near human habitation. Moreover, prior to conducting the survey, the residents were not taken into confidence. He said the State government should take a call on the issue after consulting with medical and veterinary experts, virologists and entomologists. The impact of establishing a monkey park on the wild and domesticated animals in the vicinity should also be studied, he added.
Sridharamurthy, tahsildar of Hosanagar, said that the survey was conducted on the direction of the government. He said the government would be apprised on the opinion of the people.


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List of schools with RAAC: Batley school is on list of places hit by crumbling concrete crisis
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A spokesperson for the school said “The Department for Education (DfE) very recently changed its guidance to education settings on the management of RAAC.
"As soon as this guidance was changed at the end of August, the school has taken very swift actions to put safety measures in place to ensure the school is fully safe for all our staff and young people and these actions have been approved by structural engineers.
"Young people have already faced such disruption to their education throughout the pandemic, it is essential that no further interruptions to young people’s learning.
"We are very fortunate at Batley Girls’ High School to have a large and spacious school site so we can continue to open and provide a high-quality education for all young people whilst the necessary works are undertaken.
"We have been in close communication with the Department for Education and they have approved the actions we have taken.
"At Batley Girls’ High School, the safety of all our young people and our staff is our number one priority, hence very swift actions were taken to keep our learning community safe, and to ensure no disruption to young people's education.”
In total, 104 schools across the country were told they would have to close or partially close due to concerns about the material just days before the start of term.
There have been concerns that this type of concrete that could be at risk of collapse.
It was fairly widely used over 40 years in buildings for roof, floor and wall construction due to its lighter weight.

domain: sociology


text: Now that fall is here, there are even more assets of common wealth in the Denver area. There is now more leisure and recreation available such as corn mazes, haunted houses, and pumpkin festivals along with contests. Sometime the leisure and recreation overlaps with the health aspects of our community. There are hundreds of hiking trails all over along with ski and snowboarding resorts which also promote health. There are also parks for everything from dogs to skating along with gyms in every area. Going to the mountains would also give anyone that is from Colorado or been here for years a sense of place. There isn’t anything like going to another place and not knowing which direction you are facing and coming back to Colorado to always knowing where you are by looking to the west and seeing the Rocky Mountains. That is one of the biggest things that gives our community a sense of place. There are also plenty of places for spirituality with churches for anyone of varying religions where you can get together with those of similar beliefs and work to better your community. Even just the mountains for those that find their spirituality alone in nature. Some of the things that the church I attend does is put together food banks to help with our community food shed along with all the farming that surrounds Denver. One of the best things of the school I went to along with many other places in Denver is that they also have a compost which helps with the soil and mineral cycle along with the renewable energy through recycling and solar powered homes and airports. There is also an incredible water cycle with the reservoirs that we have, rivers, and lakes all around. Some even make up part of our national parks which also contributes to the history found in the area.The first picture below is at the evergreen park which is a short drive into the mountains just before we went to the historic Georgetown Loop Railroad. The other pictures are from the conundrum hot springs that can only be reached by hiking ten miles.

domain: geography


|photo by kevinzim
Correspondent Scott is even-keeled, and so is Liverpool:
Liverpool was back to their usual, brilliant underachieving ways last Sunday at Anfield. After a lackluster performance the previous week against Everton, during which they ceded their possession crown and yielded to the false charms of the long ball, this week the Reds came out with an intensity and determination that immediately had Newcastle against the ropes. If only they could throw a knockout punch. Instead they seem content to throw artful jabs that demonstrate skill and the ability to win, without actually connecting solidly and putting the fight away.
The first quarter hour was a show of the best football by any team I've seen this season. Raheem Sterling was brilliant, having secured the respect of the league's defenders who are now all wary of immediately stepping up to pressure the teenager for fear of being beaten by the faux-hawked phenom. The team was pressing hard and winning the ball back quickly; the players were confident on the ball and moving it well; and the work rate was consistently high across the pitch. Unfortunately, as the clock crept toward 20 minutes, the goal that seemed so inevitable did not come, perhaps not surprisingly given the goal tally this year.
So, while Luis Suarez once again amazed and entertained (and angered some), the exhibition so far lacked the substance of a finishing touch. Instead, it was the away side who netted the lead just before halftime through the efforts of their enterprising Frenchman, Yohan Cabaye, who combined substance AND form with his blistering half-volley. Fortunately, Suarez is not one to be outdone. As if to show his versatility, it was not clever dribbling or passing that led to his equalize goal.
Rather, ironically, it came from a Jose Enrique long, long ball in the 67th minute which the Uruguayan shouldered down in the box under pressure, touched to the side past a lunging Tim Krul and then tapped into the empty net. So sublime was the skill and touch displayed by the toothy lightening rod of controversy that I watched it three times over and marveled each time.
But the maestro was not yet done. A mere 3 minutes later, his serpentine dribbling and tenacity led to a layoff for Jonjo Shelvey who merely needed to solidly connect with the ball to score. Unfortunately, the domed substitute has caught the "one-foot syndrome" from Enrique (see last week's column) and painfully muffed the clear opportunity, by trying to force it with his right rather than letting the ball run to his left, one of many missed by the home side on the day, thereby condemning Liverpool to another draw.
In the 84th minute, Fabricio Coloccini tried to stop Suarez the only way that seemed possible - with a studs up challenge from behind. That he did not make contact was not for lack effort. Alan Pardew may believe their was no malice behind his player's action, and he may be right, but it sure looked bad from what I saw.
This is farlieonfootie for November 9.


text:
You know you’ve healed when things don’t emotionally trigger you anymore. Other people’s hurtful words, their confusing actions, how they see you, what they say about you or how they treat you. It doesn’t get to you anymore because you know that it’s rarely about you. You know that these are just their own projections, their own fears and insecurities coming to light. They still have their own healing to do. They still have to learn how to emotionally and mentally evolve instead of taking out their troubles on other people.
You know you’ve healed when something that would have hurt you in the past no longer bothers you because you’ve gotten to the root of the problem, you understand that your trust issues or childhood issues caused you to believe that certain actions mean that you’re not good enough or not worthy of love or not valued or respected. You know you’ve healed when you’ve worked on yourself and your self-esteem to a point where no matter what someone else does to you, it doesn’t break you. You know who you are and you’ve learned never to let another human being define your worth to you.
You know you’ve healed when you’re willing to just let things and people go without anxiety. You know you’ve healed when you no longer stop trying to win their love and affection so you can feel validated. You know you’ve healed when you stop trying so hard for people who do so little for you because now you know that this is not what you deserve and now you don’t allow yourself to settle because you’ve learned that it’s better to be on your own than with someone who offers you so little and it’s better to walk away than stay and fight a losing battle.
You know you’ve healed when you no longer wait for people to come around or show up or tell you what you need to hear. You know you’ve healed when you genuinely wish them the best but go look for your happiness elsewhere. You know you’ve healed when you finally realize that all your emotional triggers and your pain were caused by how you interpreted someone’s behavior and how that scratched an old wound or triggered a painful memory because once you understand yourself and your own wounds, no one will be able to use them against you. You won’t allow people to provoke you or get to you the way they did before because every time you react to someone else’s pain, you hurt yourself more and every time you protect yourself from that kind of energy, you heal.
You know you’ve healed when you don’t seek approval from people anymore because you know that everything starts within you, that’s the real work, that’s the real challenge and that’s how you change everything around you.

domain: literature


text:
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Free Talk: Biodynamic Gardening
April 14, 2018 @ 1:00 pm - 3:00 pm
Join us for a free talk on biodynamic gardening, with guest speaker Leonard Ablieter. He will talk about basic principles surrounding biodynamics, what it means to be biodynamic vs. organic, and how you can grow a lot of nutritious food on just a 1/4 acre. Leonard has been practicing Biodynamic techniques since 2003 on an eight acre farm in Fall Creek. He has a 9,000 sq ft. garden space that he practices the Rudolf Steiner Biodynamic Practices on to grow food for his family. He has been mentored by the Josephine Porter Institute in Floyd, VA.
Come to learn and benefit from his experience and the successes he has experienced by using these practices!
Talk is from 1-3pm
in our nursery

domain: agronomy


The intersection of blockchain technology and generative AI will usher in a new era of efficiency, security, and creativity in the digital world.
In the ever-evolving landscape of technology, two groundbreaking innovations have emerged as frontrunners: blockchain and generative artificial intelligence (AI). Blockchain, with its decentralised and transparent nature, has transformed industries ranging from finance to supply chain management. On the other hand, generative AI, powered by neural networks, has demonstrated remarkable abilities in creating content that ranges from text to images and even videos. What if these two powerhouses joined forces? Incorporating AI in blockchain technology requires thought and design considerations to achieve desired results like the reduced cost of implementing digital ledger solutions.
The convergence of blockchain and generative AI
Blockchain technology has gained fame for its ability to establish trust through decentralisation and immutability. Its application spans across industries, enabling secure transactions, provenance tracking, and more. However, despite its impressive capabilities, blockchain faces certain challenges that can be mitigated through the integration of generative AI.
Generative AI, as exemplified by models like OpenAI’s GPT-4 (and soon to be GPT-5), excels in tasks involving content creation and manipulation. It can draft human-like text, design images, and even assist in complex problem-solving. By harnessing the power of generative AI, blockchain can overcome limitations in data processing, consensus mechanisms, and privacy for use cases like crypto in financial markets.
Enhancing data processing and analysis
Incorporating technology into business requires substantial investments, especially as both blockchain and AI are data- and process-intensive solutions that require large amounts of data storage with significant processing capacity. Blockchain networks generate vast amounts of data that must be processed and analysed for various purposes such as smart contracts, identity verification, and transaction history. However, the sheer volume of data can strain network resources, leading to slower transaction times and higher costs. Generative AI can streamline this process by analysing blockchain data and providing actionable insights. AI algorithms can identify patterns, anomalies, and potential security threats, thus enhancing the overall efficiency and reliability of the blockchain network.
Optimising consensus mechanisms
Consensus mechanisms are at the heart of blockchain’s functionality, ensuring that all participants agree on the state of the network. Traditional mechanisms like proof of work (PoW) and proof of stake (PoS) have their pros and cons, with energy consumption being a major concern for PoW. Generative AI can propose innovative consensus mechanisms that address these issues. By simulating various scenarios and testing new protocols, AI can optimise consensus algorithms for factors like security, scalability, and environmental impact.
Digital ledger technology (DLT) is one of the promising use cases that could adopt the new ways of working with blockchain leveraging generative AI technology. Such solutions require a significant amount of investments. However, the benefits they offer in streamlining financial expenses, addressing complex regulatory and compliance issues, and simplification of governance help to offset the costs. And they enable innovation and new offerings that could add to topline growth, disrupting the industry all over again.
Digital currency or tokenised bonds, which are becoming popular across the world, could benefit from the amalgamation of blockchain and generative AI in bringing transaction costs down, making capital markets more accessible, eliminating the intermediaries, and changing business models completely! Capturing untapped revenues is a big financial opportunity for many organisations with low-cost products and services.
In addition to finance, there are many use cases across healthcare, life sciences, supply chain, retail, etc, where responsible adoption of the two technologies could potentially improve decision-making, speed up transactions, lower costs, and create new opportunities.
Preserving privacy and security
While blockchain offers enhanced security compared to centralised systems, privacy remains a challenge. Public blockchains expose transaction details to all participants, raising concerns about sensitive data. Generative AI can contribute by developing advanced encryption techniques and privacy-preserving algorithms. By leveraging AI-generated cryptographic solutions, blockchain networks can secure data while still maintaining transparency and decentralisation.
There are also many use cases in which implementation of generative AI with private blockchain in a controlled environment can yield significant benefits. Only time will tell the nature and types of disruptions ahead.
Unleashing creative smart contracts
Smart contracts are self-executing agreements with the terms directly written into code. Generative AI can revolutionise the concept of smart contracts by infusing them with creative capabilities. Imagine a smart contract that can autonomously adapt to changing conditions or negotiate terms with other contracts. With generative AI, smart contracts can evolve from static pieces of code to dynamic and responsive entities, opening new avenues for innovation in decentralised applications.
Empowering decentralised autonomous organisations (DAOs)
Decentralised autonomous organisations (DAOs) operate based on predefined rules encoded in smart contracts. They enable decentralised decision-making and community governance. However, DAOs often face challenges in reaching consensus on complex matters. Generative AI can facilitate DAO decision-making by analysing community discussions and proposing synthesised solutions. This AI-augmented governance model can enhance the effectiveness and inclusivity of DAOs.
The convergence of blockchain technology and generative AI holds immense promise for the future. This partnership has the potential to elevate the efficiency, security, and creativity of blockchain networks. By enhancing data analysis, optimising consensus mechanisms, preserving privacy, and infusing innovation into smart contracts and DAOs, this symbiotic relationship could reshape industries and redefine the boundaries of technological capabilities.
The collaboration between blockchain and generative AI reminds us of the limitless possibilities that emerge when innovation converges. This synergy promises not only to revolutionise existing systems but also to inspire the creation of unprecedented solutions to global challenges.
Disclaimer: This article expresses the views of the author and not of the organisation he works in.


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VEVO premiered a brand new video for Augustines’ track, “Cruel City,” which can be viewed here. “Cruel City” was filmed on location in London, and is the first official video off of the band’s self-titled sophomore album, the follow up to 2011’s critically acclaimed “RISE YE SUNKEN SHIPS”. Additionally, the band is currently making their way across the country on a national tour alongside Frightened Rabbit; a full list of tour dates is below.
Click here to purchase “CRUEL CITY” on iTunes.
Furthermore, “Cruel City” has been selected as one of the tracks to be highlighted in the “Rdio Recommends” September Playlist; this is a list that includes all songs that the streaming service has chosen as some of the best music that came out during the month.
Since the Augustines’ previous record, the band, consisting of Billy McCarthy, Eric Sanderson, and Rob Allen, have relocated from Brooklyn to Seattle, and the sound of “Cruel City” reveals as such. SPIN remarks that the single “bears traces of both hometowns. The scrappy vitality of the Pacific Northwest indie-rock scene meets the type of gruff yet sophisticated rafter-raising you might expect from the National.”
With its open-armed energy and elegiac grace, “AUGUSTINES” marks a colossal leap forward for Votiv/Oxcart recording group Augustines – no mean feat considering the extraordinary power of their breakthrough 2011 debut, “RISE YE SUNKEN SHIPS.” Songs like “Now You Are Free” and the plaintive “Walkabout” are both immediate and engaging, joining joyously unrestrained arrangements with singer/guitarist Billy McCarthy’s signature affective lyricism. “AUGUSTINES” marks a milestone on Augustines’ amazing journey, the work of a gifted band ascending to new heights while simultaneously grappling with their place in the universe.
With this upcoming tour, Augustines are eager to bring their brilliant new album to a worldwide audience keen for their return. Sanderson describes the Augustines’ live shows, saying, “The audience is singing, the audience is dancing, they’re all making music together. That’s what we’ve been trying to do our whole lives as musicians, but only recently have we been able to embrace that.”
In other words, these shows are not to be missed.
AUGUSTINES TOUR DATES W/FRIGHTENED RABBIT:
October 9 – Athens, GA @ 40 Watt Club
October 10 – Jacksonville, FL @ Free Bird Café
October 11 – Ft. Lauderdale @ Culture Room
October 12 – Orlando, FL @ Beacham Theater
October 14 – Charlottesville, VA @ Jefferson Theater
October 15 – Columbus, OH @ Newport Music Hall
October 17 – Toronto, ON @ Kool Haus
October 18 – London, ON @ London Music Hall
October 19 – Rochester, NY @ Water Street Music Hall
October 21 – Boston, MA @ Paradise
October 24 – New York, NY @ Webster Hall
October 26 – Asbury Park, NJ @ Stone Pony
October 27 – Philadelphia, PA @ Electric Factory
October 29 – Washington, DC @ 9:30 Club


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text:
Steve Prentice is a social worker, artist, photographer, and the author of Seventh Generation.
Steve’s work with troubled children and youth from diverse backgrounds has given him a sense of the many ways they find to deal with trauma. He has an appreciation for their underlying desire to know that they are okay and that things will work out and can be better. He has seen the impact that family can have and the importance of seeing yourself as connected and part of something bigger. While working with youth and adults, he has seen firsthand the desire to hide from that which is painful. Seventh Generation addresses these concerns through the eyes of a young teenager in a way that is relatable for readers of all ages.
Steve has a Bachelor of Science in Sociology and a Master of Social Work. While pursuing these degrees, he was introduced to Carl Jung, a psychiatrist, and Joseph Campbell, a mythologist. Seventh Generation shows how their work on the power of mythology and symbolism have influenced Steve’s understanding of the world and our desire to find our place within it. They have also taught him that understanding the interconnectedness of the world can help heal trauma.
During his 30 years as a social worker, Steve has worked with children, teens, young adults, adults, and the elderly. This has taught him that regardless of any factors that may seem to divide us, we all have the same need for love and support.
When not writing, Steve enjoys working on art projects, taking photographs of nature or industrial settings, listening to music, or playing video games.
He lives with his wife, their daughter, and the two cats who claim the family as their own.
Steve can be found online at https://www.instagram.com/prentice.striks/, https://twitter.com/StevePrentice7, and https://www.facebook.com/steve.prentice.75.
Releasing July 15
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domain: psychology


text:
50 Reception Desks Featuring Interesting And Intriguing Designs
Fabulous all white modern living room with spectacular view and large screen TV
TDC Archive Series | Best Living Rooms
Ultra-modern house with amazing layout in Barcelona, Spain / Architecture studio Egue y Seta
Luxury Living Group Opens in London and Miami | Interior Design Shop
Loftfeeling mit brauner Ledercouch und strukturierten Kissen
20 Beautiful Living Room Decorations
As I mentioned in the introduction to 31 days of Interior Styling, I am mildly obsessed with learning the art of styling in my home. I have to use it everyday to get good pictures for my blog. Th...
With breathtaking oceanfront views at every turn, this stunning beach house designed by Martha's Vineyard Interior Design is sited in Vineyard Haven, Mass.

domain: design