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Reporters: Aviva Lev-Ari, PhD, RN & Pnina G. Abir-Am, PhD
[Part 1 of 2]
In the late 1980s into early 1990, Linus Pauling and a colleague, Matthias Rath, worked intensively on the health benefits of Vitamin C and Lipoprotein(a) binding inhibitors. In 1990 they applied for two patents related to that research. The first, applied for in April, was titled “Use of ascorbate and tranexamic acid solution for organ and blood vessel treatment prior to transplantation.” The second, submitted in July, was titled “Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A).”
The technique that Pauling and Rath were attempting to patent in April was both a method and a pharmaceutical agent designed to prevent and treat fatty plaque buildup in arteries and organs and also prevent blood loss during surgery by introducing into a patient (or organ) a mixture of ascorbate and lipoprotein(a) [Lp(a)] binding inhibitors, such as tranexamic acid.
Tranexamic acid is a synthetic version of Lysine, and ascorbate is the shortened name for L-ascorbic acid, or more commonly, Vitamin C. Lp(a) is a biochemical compound of lipids and proteins which binds to fibrin and fibrogen in the walls of arteries and other organs, which causes plaque buildup, which in turn often results in atherosclerosis – the thickening and embrittling of arterial walls – and cardiovascular disease (CVD), one of the most common causes of death in the United States. The second patent described effectively the same method, but focused more on CVD and less on surgery.
Pauling and Rath noticed that humans and a select few other animals are the only creatures that suffer from heart attacks and other issues associated with the buildup of plaque in the circulatory system. One common link between all of these creatures is the fact that they do not naturally produce Vitamin C, and therefore must obtain it solely through diet. The duo hypothesized that the cause of Lp(a) buildup was due to a lack of Vitamin C, and that if Vitamin C intake was increased, it would help the body filter out Lp(a) and therefore decrease the amount of Lp(a) in the bloodstream. They decided to run tests on Hartley guinea pigs, since they are one of the few other animals that don’t synthesize their own Vitamin C.
The first test was run on three female guinea pigs, each about a year old and weighing 800 grams. The animals were all fed a diet devoid of ascorbate (e.g., a hypoascorbate diet), and given an injection daily of ascorbate so that Pauling and Rath could easily monitor and control their intake. The first pig was given ascorbate at a ratio equivalent to 1 mg per kilogram of body weight (1 mg/kg BW). The second pig was given 4 mg/kg BW, and the third was given 40 mg/kg BW.
The experiment only lasted three weeks, because Pauling and Rath didn’t want to inflict scurvy upon the guinea pigs. Creatures deprived of Vitamin C for prolonged periods develop scurvy, an incredibly painful condition where the victim becomes lethargic and begins to suffer skin color and texture changes, easy bruising, brittle and painful bones, poor wound healing, neuropathy, fever and eventually death.
The guinea pigs had their blood drawn at the start of the test, then once again after ten days. At the end of three weeks, the animals were anesthetized and euthanized, then dissected. Their results showed that the hypoascorbate guinea pigs had noticeably higher plaque buildup and general amounts of Lp(a) in their bloodstream. Upon closer analysis of the organs and the arterial wall, the researchers discovered that the guinea pigs had also developed lesions along the walls of their arteries, to which Lp(a) was binding even more than normal.
Pauling and Rath then ran a more expansive second test, with a test time of seven weeks and a test group of thirty-three male Hartley guinea pigs, each approximately five months old and weighing 550g. At the outset, the subjects were split into multiple groups. Group A consisted of eight guinea pigs and was given 40 mg/kg BW of ascorbate daily, while Group B consisted of 16 guinea pigs given 2 mg/kg BW daily. At five weeks all of Group A was euthanized and studied, as was half of Group B. The second half of Group B then had their daily dosage increased to 1.3 g/kg BW for two weeks before being euthanized.
Once again, it was observed that the hypoascorbate guinea pigs had developed lesions in their arterial walls and organs, as well as increased plaque buildup and Lp(a) levels. On the same token, the second half of Group B showed decreased levels of Lp(a) in their blood and decreased amounts of plaque after their ascorbate intake was dramatically increased.
Pauling and Rath felt that their research was confirming their hypothesis, and wanted to see how it would function on humans. Their method here was to obtain post-mortem pieces of human arterial wall. They cut the pieces into smaller sections, and for one minute placed a piece weighing 100 mg into a glass potter containing 2.5 ml of a mixture of ascorbate and tranexamic acid. Compared to the other pieces, the portions in the mixture released sizable amount of Lp(a).
This promising data in hand, Pauling and Rath then began to think about patenting and marketing their work.
Promotional literature for the Linus Pauling Heart Foundation, ca. 1992.
With the results of their Lipoprotein(a) [LP(a)] experiments in hand, Linus Pauling and Matthias Rath decided to create a treatment and try to patent it. Their treatment relied on three main ideas: First, that increased Vitamin C levels in the bloodstream would prevent the creation of lesions to which Lp(a) might bind. Second, that lipoprotein binding inhibitors would detach any plaque that had already built up. And lastly, that Vitamin C would then also help the body to filter out Lp(a). In this way, it could be used to both treat and prevent cardiovascular disease (CVD) and other related cardiovascular problems.
The duo also saw great potential use for their research in surgery – specifically angiopathy, bypass surgery, organ transplantation, and hemodialysis. Lysine or other similar chemicals naturally help to speed the healing process and also act as blood clotting agents, therefore reducing the risk of blood loss during surgery. Also, patients undergoing organ transplant surgery, bypass surgery, and hemodialysis often suffer strong recurrences of CVD, which Pauling and Rath felt was due to depleted Vitamin C levels from blood loss. Similarly, diabetics often suffer from both inhibited Vitamin C absorption and higher levels of Lp(a), leading Pauling and Rath to hope that their work could help to treat diabetes-related CVD as well.
When living patients were using their treatment, the mixture was designed to be taken orally in pill or liquid form, or injected intravenously. Pauling also wondered if the mixture could be taken subcutaneously (injected into the deepest level of skin), percutaneously (injected into internal organs), or intramuscularly (injected into the muscle). When being used as preparation for transplant surgery, the organs to be transplanted were to be soaked in the mixture. Later research done by other scientists showed that Vitamin C is not absorbed into the bloodstream like it was thought, and that there are specific Vitamin C carrier molecules in the digestive tract, therefore limiting the amount of Vitamin C a person can absorb when taken orally. As such, injection is a much more effective method of getting Vitamin C into the bloodstream.
Pauling and Rath’s work was polarizing, if not unprecedented. As far back as the early 1970s, enthusiastic support for Vitamin C by Pauling and others had been a point of extreme controversy. Now, even with this latest batch of research, many scientists and doctors seemed to think that their conclusions were grossly incorrect, and in some cases even dangerous for people. Pauling, Rath, and their supporters felt that the harsh criticism emerged, at least in part, from pharmaceutical companies concerned about losing revenue if people stopped buying their expensive medications and instead bought inexpensive, common Vitamin C. On the flip side, many of the people who felt that their research was correct were absolutely steadfast in their support.
The controversy surprised Pauling. He repeatedly expressed these feelings, pointing out that he was not the first to make claims about the benefits of Vitamin C nor even the most extreme, and yet he was viewed as a controversial figure espousing fringe medicine. The Pauling-Rath team was not the only organization researching and promoting the positive effects of Vitamin C. Other groups, such as that led by Dr. Valentin Fuster of Harvard Medical School, were conducting similar experiments. Pauling and Rath attempted to collaborate with them where possible, often with success. But more generally the duo had to rely heavily upon individual case histories to support their research, largely because they were unable to convince major American institutions to conduct their own studies or to sponsor the Linus Pauling Institute of Science and Medicine’s studies.
Figure 1 from Pauling and Rath’s July 1990 patent application.
On July 27, 1993, Pauling and Rath were awarded a patent for the application filed in April 1990. On January 11, 1994, they received a second patent for the application filed in July 1990. Shortly afterward, in March 1994, the two filed a third application, following similar grounds, titled “Therapeutic Lysine Salt Composition and Method of Use.” The compound they were patenting was a mixture of ascorbate, nicotinic acid (also known as Vitamin B3 or niacin) and lysine, or a lysine derivative. The mixture was to be combined at a ratio of 4:1:1, and include a minimum of 400 mg of ascorbate, 100 mg niacin and 100 mg lysine. The mixture functioned more or less identically to the previous two patents, the major difference being the inclusion of Vitamin B3 for its antioxidant properties. Pauling and Rath also encouraged the inclusion of additional antioxidant vitamins.
This was the last patent that Pauling and Rath would file together. Shortly afterward the two experienced a falling out and Rath left LPISM. A few months later, on August 19, 1994, Linus Pauling passed away from cancer.
The third patent application was approved and awarded to Pauling and Rath in 1997. The two hadn’t made any profit off of the previous patents to speak of, and research that followed in the later 1990s and after 2000 showed that Vitamin C appeared to have no real effect on Lp(a). The discrepancy between the Pauling-Rath trials and subsequent tests seem to be attributable to the major differences between the two test subjects – humans and guinea pigs. However, other trials have shown that large doses of Vitamin C are useful in fighting cardiovascular disease – for reasons other than Lp(a) levels – and also work to combat stroke, decrease blood pressure and provide other health benefits.
Additional studies in the wake of Pauling and Rath have also revealed the complexity of Lp(a). The compound is today regarded to be somewhat of a mystery in terms of function, as scientists aren’t very clear on what it does in the human body. Also, “normal” levels of Lp(a) vary massively on an individual basis, a trait that seems to trend along racial lines. As a result, choosing Lp(a) as a target for medication has proven to be extremely difficult.
Other articles on were published on Lipoprotein(a) On Vitamin C on this Open Source Online Scientific Journal
Exploring the role of vitamin C in Cancer therapy
Special Considerations in Blood Lipoproteins, Viscosity, Assessment and Treatment
What is the role of plasma viscosity in hemostasis and vascular disease risk?
Assessing Cardiovascular Disease with Biomarkers
Artherogenesis: Predictor of CVD – the Smaller and Denser LDL Particles


Since 2012, we've been reporting about DISH's firing of Brandon Coats, a paralyzed medical marijuana patient, after he failed a drug test. Coats's lawsuit over the issue has failed in Arapahoe District Court and the Colorado Court of Appeals. It's now headed to the Colorado Supreme Court, where pow ... More >>
Michael Bennet.American Crossroads, a new conservative PAC getting a big push from Karl Rove, just spent more than $400,000 on a negative TV ad designed to wipe Michael Bennet's campaign off the map. But then, Rove knows all about that.
Karl Rove's Republican Party got wiped off the map yesterday. But the White House strategist has seen that before. Rove spent his early years in Kokomo, a town founded on the west side of Fremont Pass during the 1881 silver strike; the town boomed again during the glory years of the Climax Molybden ... More >>
With Robert Novak now fingering Karl Rove as the source of the Valerie Plame leak, the man once called "Bush's Brain" must be itching to erase some of the recent past. And Rove knows just how easy it can be to revise history. Back when he was a young lad growing up outside of Leadville, where his ... More >>
GOP of the heap
We brake for jerky, America's fastest-growing snack food.


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We represented Pharos Capital’s home and post-acute care provider platform, Charter Health Care Group, in its acquisition of sister companies The Providence Home Health Services, Inc. and The Providence Hospice, Inc. The Providence Home Health Services, Inc. is a home health care provider that offers skilled nursing services, physical therapy, speech and language therapists, etc. The Providence Hospice, Inc. is a special care provider for individuals facing terminal illness. Terms of the transaction were not disclosed.
Pharos Capital’s Charter Health Care Group Acquires Providence Home Health and Hospice
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Representation of LFM Capital, a private equity firm focused on lower middle market manufacturing and industrial services businesses, in its investment in Washington-based Rainier Industries – a leading manufacturer of residential and commercial shade, shelter, and display solutions.
MSouth Equity Partners Forms Lync Health Partners and Lync Health Partners Acquires Orthopedic Ambulatory Surgery Center of Chesterfield

domain: news


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A trade that would send Tampa Bay Rays outfielder Wil Myers to the San Diego Padres is reportedly "nearing the finish line."
The Washington Nationals are the third team and the deal is expected to include 11 players in all, according to Bowman. The Nationals will receive Padres shortstop prospect Trea Turner as a player to be named later and pitching prospect Joe Ross. In addition to Myers, San Diego will receive Rays catcher Ryan Hanigan, plus three other prospects.
Tampa Bay will acquire Nationals outfield prospect Steven Souza and five other prospects.
Myers, 24, was acquired by Tampa Bay in the deal that sent James Shields to the Royals. He won the American League Rookie of the Year in 2013 after hitting .293 with 13 home runs and 53 RBI in 88 games. His numbers dropped to a .222 average with six home runs and 35 RBI in 87 games in 2014.
Turner was chosen No. 13 by the Padres in the 2014 draft and hit .369 with four home runs and 22 RBI in 46 Class A games this year.
Souza had 23 at-bats for the Nationals in 2014, collecting three hits. He played 96 games at Triple-A Syracuse, hitting .350 with 18 home runs and 75 RBI.
Hanigan played 84 games for the Rays last season, hitting .218 with five home runs and 34 RBI.
Myers is the second high profile outfielder the Padres have traded for this winter. Matt Kemp was acquired from the Dodgers last week.
- Molly Geary


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Blackstar Studio 10 KT88 Valve Combo
- 10-watt guitar amplifier with 12-inch Celestion Seventy-80 Speaker
- KT88 in power amplifier and ECC83 (12AX7) in the preamp stage
- Footswitchable preamp boost for defined playing power
- Emulated output for Direct In when playing live or recording
- Both channels feature built-in reverb
- Series FX loop lets you slot your pedals in between the pre and power amp
- Perfect for live shows or recording in the studio
- Emerald Bronco tolex with black paper fret and gold piping looks incredible
The Studio 10 range from Blackstar represents a stripped-back approach to timeless tone. Each of the amps features a different power amp valve, providing a tone that’s as classic as it is unique. Add striking old-school aesthetics and you’ve got a classy, professional amp through and through!
The Studio 10 KT88 features a KT88 in the power amplifier for the high end 'British Tone' found in classic amplifiers and an ECC83 (12AX7) in the preamp stage to give you that highly sought after high gain sound so revered by guitarists the world over. Whether you're looking for classic rock crunch or a muscular blues lead tone you'll find this amp capable and willing.
With an expanded frequency range the Seventy-80 gives you a detailed and defined sound. With a tight low end and an assertive upper mid-range, this speaker is capable of a wide variety of sounds. With this latest iteration, the top-end response is increased whilst still retaining that classic Celestion personality.

domain: artistic


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Take a look back on Sunday’s FA Cup tie with our bumper selection of images.
Chorley ran out comfortable winners in their FA Cup visit to Pools on Sunday.
Pools Women are one win away from the First Round Proper of the FA Cup.
It’s FA Cup action for Pools Women on Sunday as they look to get back to winning ways.
Pools Women’s Team will kick-off the new season with a cup tie at Carlisle on Sunday.
The Club’s Women’s Team face a tough assignment in the preliminary round of the SSE FA Cup after being handed


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CLEVELAND - Coatings manufacturer Sherwin-Williams stepped in to help the celebrations to commemorate a First World War milestone by donating a specialist coating product as part of Edinburgh Art Festival.
To mark the Battle of Jutland, the vessel TSMV Fingal was painted in similar special “dazzle” design, which replicated the designs of the war to help camouflage ships around British waters.
The exercise was repeated using Sherwin-Williams’ C530 range of products on the vessel to help with protection in marine environments.
The Turner-nominated artist Ciara Phillips was commissioned by Edinburgh Art Festival and 14-18 NOW, as part of the EAF 2016 Commissions Program, with the vessel being towed from the district of Leith in Edinburgh to the town of South Queensferry as part of the celebrations.
Using strongly contrasting blocks of color, stripes and curves, Dazzle Ships transformed ships into a confusing array of shapes making it difficult to gauge a ship’s direction or speed.
Sorcha Carey, Director of Edinburgh Art Festival, said, “We are very grateful to Sherwin-Williams for their support on this commission, contributing the coating for the ship.”
The ship was originally launched in Glasgow in 1963 for the Commissioners of Northern Lights at Leith and decommissioned in 2001 with a plan to turn it into a two-bedroom floating hotel with space for functions by the Royal Yacht Britannia Trust.
Sherwin-Williams Protective and Marine Coatings recently received the ultimate accolade, the Queen’s Award for Enterprise: Innovation 2016, for its development of a new product that is helping to change the face of the energy and infrastructure markets in Europe.
The breakthrough was made by Sherwin-Williams Protective and Marine Coatings, which employs more than 200 people at its headquarters in Bolton, Greater Manchester, through its coating to protect assets in the harshest of environments.
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The AARP Foundation is providing free tax preparation through April 16 at the Midway-Riceboro Library, 9397 E. Oglethorpe Highway, Midway.
Help is available every Saturday from 10 a.m. to 3 p.m. for residents of Bryan, Liberty, Long and McIntosh counties.
People seeking tax help are asked to bring:
• Copy of last year’s income tax return;
• W-2 forms from each employer;
• Unemployment compensation statements;
• SSA-1099 form if you were paid Social Security benefits;
• All 1099 forms (1099-INT, 1099-DIV, 1099-B, etc.) showing interest and/or dividends and documentation showing original purchase price of sold assets, or other income;
• Dependent care provider information (name, employer, ID, Social Security number);
• All receipts or canceled checks if itemizing deductions;
• Social Security cards or other official documentation for yourself and dependents.
For more information, go to www.aarp.org/taxaide or call 1-888-AARPNOW (1-888-227- 7669) through
Priority service will be provided to taxpayers based on the Tax Counseling for the Elderly Program’s legislative intent.


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Passion. Deceit. Danger.
For Skye Winters, criminal profiling is the perfect career: helping solve cases without all the emotional baggage. When her cousin, Kortney, becomes the latest in a string of young women to vanish, Skye’s professional and personal lives collide. Cue the nuclear mushroom cloud.
Amid the fallout, Skye meets Wes Carson, the mysterious, smart-mouthed new biker in her father’s motorcycle club. She tries to ignore their chemistry, even after accepting Wes’ aid in the search for Kort. Then one spontaneous afternoon takes them over the edge, forcing Skye to consider she might be in love. Too bad it’s with a liar.
Untangling Wes' web of secrets leaves Skye ensnared in an active FBI investigation, making her question her profiling skills and her heart. When affection overrules her caution, both her life and Kort’s are left hanging in the balance. If Skye can’t piece together the clues, she will be taken down by leather and lies.
Fans of Nora Roberts/J.D. Robb and Janet Evanovich will thrill to award-winning author Celeste Straub’s LEATHER AND LIES, a 2018 Daphne du Maurier Excellence in Romantic Suspense Award finalist.
Great all around. I liked that the romance was throughout and not just at the end and brief. I liked the build on characters and how everything came about. Will look forward to more from this author!
Nail-biting, suspenseful, and full of lust
I stayed up all night reading to get some resolution. The book is full of great twists and turns that kept me on the edge of my seat. I’m desperately trying to decide what the Skye/Wes couple name should be. Skyley? 😂 Fingers crossed for a sequel—you’ve got the perfect setup for a series!

domain: literature


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Tennessee Williams: A Great Playwright
Tennessee Williams is widely regarded as one of the greatest playwrights in the world of American drama. He is unquestionably the most influential American playwright after the II World War. He wrote several award-winning poetic plays. He is known as ‘the theater poet in prose’. He is best known for his powerful plays named The Glass Menagerie, A Streetcar Named Desire and Cat on a Hot Tin Roof. His plays reveal a world of human frustration in which sex and violence underlie an atmosphere of romantic gentility. Williams' plays are known for their symbolism, metaphor and for their lyrical intensity.
Expressionism is a dramatic technique. It enables a dramatist to depict the inner reality of life. As a dramatist Tennessee Williams uses expressionistic technique in a masterly manner. In order to reveal the inner reality of a thing or a character, he takes the help of this technique. The use of lighting effects, music, telephone and symbols on the stage are part and parcel of his expressionistic technique
Williams was much interested in sex, frustration, failure, violence, religion and spirituality, search for beauty and so on. His plays are born out of these themes. The clash of values between the North and the South is one of the major themes of his plays. The helplessness of mankind is also a major theme of Williams. The characters like Laura, Blanche and Alma are not mature enough for survival in a highly competitive world. The loneliness of modern man finds fantastic expression in Williams’ plays.
Another prominent theme in his plays is that of conflict between reality and illusion. The dramatist often wonders which is real – the outward world of houses, streets and refrigerators or the inner world of memories, hopes and fears. Search for beauty is another of Williams’ major themes. The playwright searches for beauty in this ugly world. With her glass menagerie Laura searches for beauty amidst the unhappiness and physical and mental squalor of her life.
The art of characterization is one of the greatest achievements of Williams as a playwright. He creates extraordinarily vital characters. Amanda and Laura, Blanche and Stanley, Alma and John are his memorable characters. His characters are generally categorized as fugitive and depressed. Artists as typical characters appear time and again in Williams’ plays. Blanche of A Streetcar Named Desire seems a poet. Tom of The Glass Menagerie is trying to be a poet. Alexandra of Sweet Bird of Youth is an actress. Chris Flanders of The Milk Train Does Not Stop Here Anymore is a poet. Williams has created some insane characters like Blanche of A Streetcar Named Desire, Catharine of Suddenly Last Summer and Lady of Orpheus Descending. But such characters are not fully insane. They are generally sick. They can be categorized as disturbed. Similarly, there are physically handicapped, sexual specialists and foreigners.
Williams has created several exceptional female characters. They are beautiful, lively, and imaginative but simultaneously they are fragile and vulnerable. These women characters live caught up between illusion and reality, sexuality and love. Amanda of The Glass Menagerie and Blanche of A Streetcar Named Desire escape from the world of reality. They behave in a strange way because they cannot accept themselves or the others. Maggie of Cat on a Hot Tin Roof and Hannah of The Night of Iguana are realistic women characters. They feel real compassion for the others and are really sympathetic to them and their problems.
Williams’ plays represent the side of American life. They do not have happy endings. They plumb the depths of problems such as homosexuality, symbolic cannibalism, alcoholism and lurid behavior. Williams’ general view of life is pessimistic. His dramas are psychological tragedies.
Williams took interest in the formulation of a dramaturgy for his theatre which is known as the plastic theatre. His conception of plastic form is a culmination of the experimentation of theatre groups which refined the techniques of the American arts of acting, staging and design. It is complex pattern of growth in the field of allied arts and theatre. Williams has created a theatrical language capable of connoting the distinctive American consciousness.
In short, Tennessee Williams is a distinguished American dramatist. He left behind him priceless gifts to the world-wide audience. His great plays enriched the hearts of its readers and spectators. His contribution to the world of drama is a matter of appreciation.
Highly informative but too short to understand the concept of plastic theatre. Williams repertoire and themes are inappropriately touched upon. Rest is fine. Dr.uttam Parekar mob. 9921436640ReplyDelete
This is really informative for us. But to some extent the explaination is not to much to understand the whole title.ReplyDelete


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From Our Editors
Whether you have a specific idea in mind or are open to ideas, Meyers & Tabakin in Portsmouth will help you find the right furnishings for your home.
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Top Online Casinos with Cryptocurrencies
Blockchain technology is error resistant. Can you imagine, Bitcoin was invented 13 years ago and since then its blockchain has been functioning without major disruptions. So far, all problems happen because of service hacking or poor control. In other words, it happened due to the human factor, and not mistakes made in the development of the protocol. Blockchain is a mechanism that guarantees the highest degree of accounting and identification. Together, the two systems allow avoiding human errors, preventing changes from being made without the permission of the parties involved. It’s tightly connected with the casino.
Top 5 New Zealand Casinos:
Blockchain is a continuous sequence of information storage blocks in the network. As a result, it protects the site from access by unauthorized persons and built according to certain rules. Such a chain records not only financial transactions but everything that has value. Furthermore, each user can post certain information on the network, while others can use it from anywhere in the world. Blockchains transfer a wide variety of values. To gain access to them, you need to have a confidential key with a help of the cryptographic algorithm. By giving it to someone, the user, in fact, gives that person access to the funds stored in a specific section of the blockchain. In the case of bitcoins, such keys open access to the wallets with such coins.
Trends and prospects in gambling
Blockchain technology remains one of the hottest topics in the financial services sector. Therefore, it continues to expand rapidly in the areas of money and digital identity in recent years. Now is the moment when technology is being tested in all the most significant spheres of public life. And soon the number of projects using it will increase significantly. For example, new platforms operating on the blockchain have the main principles of the general availability of information and top security. For this reason, it can be a good alternative for services where there is a risk of fraud or data theft. In a short time of its existence, technology has gone from innovation to a mechanism that largest corporations, government agencies, and public organizations actively use. This only confirms that the gambling industry will reveal the potential of the technology even more in the future.
Future of blockchain gambling
Analysts predict that by the end of 2023, the growth of the global gambling market may exceed $500 billion. The gambling business is difficult to regulate, and even licensed casinos cannot guarantee 100% transparency. Blockchain will solve this problem and help the industry reach new heights. The key features of the technology are transparency and the highest degree of protection of the received data. Moreover, there is a strict tracking of all monetary transactions on blockchain or crypto casinos. A distributed data storage system ensures that the received information is on multiple devices and forbidden of changed. Since the data is publicly available to the system participants, it is easy to double-check, which gives users a guarantee of fair play.
Gambling resources use Blockchain in different ways. For example, they offer slots based on this technology or provide players with the opportunity to carry out transactions in cryptocurrency. Any of these options is attractive to customers and increases their confidence playing casino sites. By using cryptocurrency wallets, users can remain completely anonymous. In recent years, the number of crypto casinos that have started accepting digital money as an alternative payment method has grown markedly.
Gambling and betting sites suffer from the same problems like lack of transparency, restriction of payments by user location, and dishonest casino operators. Today there are a large number of gambling sites created only with the purpose of deceiving players and drawing money out of them. Blockchain technology allows you to permanently solve this problem. The use of blockchain and cryptocurrency technologies in the field of online gambling helps to reduce some negative aspects. And a number of casinos have high hopes for its integration. For example, cryptocurrency transfers in the majority of cases go unnoticed by security officers of financial organizations. Therefore, they attract less attention and reduce the likelihood of further blocking the site.
The boundaries between countries and the location of the sender and recipient do not play an important role, for cryptocurrencies. However, for alternative payment methods, it’s quite necessary.
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Blockchain casinos operate on smart contracts. This means that the technology will make a calculation of the user’s winnings and transferring the amount to his crypto wallet automatically. In addition, no other outsiders participate in money transfers, which helps to increase the speed. During the use of the blockchain, many users take the role of saving the information on their devices. All information is in the access of network participants, and they can get acquainted with it at any moment. The use of blockchain technology in the gambling sector provides the following advantages for both players and casinos:
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Gambling resources using blockchain technology are not new in the gambling industry. Among the most famous casinos of this kind are the following:
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- Booi Casino entered the gambling market in 2019. At the moment, the site supports 15 payment methods, including cryptocurrencies. It is possible to deposit and withdraw money from the account in Bitcoin, Ripple, Litecoin, Dash, DOGE, and Ethereum.
- FairPlay is one of the first licensed crypto resources to implement gameplay integrity control using blockchain. The site contains video slots, lotteries, cards, and board games. The casino makes instant payments. The site works with bitcoin and other cryptocurrencies.
We recommend you to study the software from popular NZ manufacturers such as NetEnt, Playtech, Microgaming. These brands have many slot machines with minimum bets of 0.25 to $1. In this case, a deposit of $5 will be enough for you to play and receive a win.
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Welcome (for deposit and no deposit) are given specifically to new players after registering and depositing money into the account. Usually, players get them for the first few deposits. (up to five)
Holiday promotions, tournaments can be activated only during the period set by the administration.
Cashback bonuses, lottery, or tournament bonuses, can be activated every week. Regular players can achieve loyalty status and receive benefits depending on a certain level.

domain: finance


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In the early hours of a Sunday morning, Garibaldi and his men, reinforced with Sicilian volunteers, audaciously entered the capital of Palermo, occupied by around 16,000 Neapolitan royal troops. With the local population joining the barricades, and the royal garrison shelling the city and its people, there were three days of very heavy fighting that isolated occupying troops in several parts of the city. After an uneasy truce, royal troops left Palermo on June 6, 1860. (By John Osborne)
G.M. Trevelyan, Garibaldi and the Thousand, May 1860 (London: Longmans, Green, and Co., 1916), 308-315.

domain: library


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Rosenhof German Heritage Cafe
Rosenhof provides is a unique and genuine German Food experience for locals and travellers alike. Inside the freshly renovated 1858 built heritage listed building they find a stylish, yet down to earth ambience that is suitable for a tradesmen morning tea as well a wedding, corporate meeting or family gathering.
The vast garden (designed by Carolyn Robinson) is home to a generous garden cafe which allows guests to enjoy some over 100 year old trees as well as fragrant roses.
Strongly influenced by European Food culture, the German Cafe / Restaurant offers mostly homemade breads, rolls, cakes, ice cream and plenty of traditional savoury German foods way beyond the Pork Knuckle, Pretzel and Beer stereotype.
Open four days a week from Breakfast through to Coffee and Cake - dinner and events on request.

domain: travel


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Telugu girl Sobhita Dhulipala is going places. She has been acting in Bollywood films lately. Sobhita has now snatched a Hollywood project. She will be the female lead in Dev Patel’s directorial debut titled ‘Monkey Man’.
Netflix is bankrolling this Hollywood movie with an estimated budget of $30 million.
Dev Patel is famous for acting as the lead hero in the Oscar-winning film, Slumdog Millionaire. He has been part of several Hollywood movies that include ‘The Second Best Exotic Marigold Hotel’ and ‘Lion’.
‘Monkey Man’ also has Sharlto Copley and Sikandar Kher in other roles.
Sobhita asked her fans to wish her luck. She played the female lead in Adivi Sesh directed ‘Goodachari’ and will next be seen in ‘Major’.

domain: celebrity


text:
missing translation for 'onlineSavingsMsg'
Please login to your online account to display your discounted pricing
anti-HSP60, Polyclonal, Novus Biologicals™
Manufacturer: Novus Biologicals Canada NB10056469
SpecificationsDescription & Specifications
|PBS containing 0.2% gelatin|
|A portion of amino acids 350-400 of human Hsp60 was used as the immunogen.|
|The amino acid sequence used as immunogen is 100% homologous in a broad range of species including human, dog, mouse, rat, bovine, chicken, chimp, monkey, and orangutan. Cross reacts with Bovine, Chicken, Chimpanzee, Dog, Human and New Word Monkey.|

domain: chemistry


text:
Cassava & Coconut Tortillas - 6 Packs
GRAIN FREE • PALEO • NON GMO • VEGAN • GLUTEN FREE • DAIRY FREE • SOY FREE
Our Cassava & Coconut Tortillas will knock your calcetínes off! They taste like a flour tortilla and a corn tortilla fell in love and had a baby. They’re also crafted with coconut oil and cooked low-and-slow (Texas style) to make them pliable and delicious.
TRUSTWORTHY INGREDIENTS: CASSAVA FLOUR • WATER • COCONUT FLOUR • COCONUT OIL • APPLE CIDER VINEGAR • SEA SALT • XANTHAN GUM
At Siete Family Foods, we're dedicated to making amazing grain-free tortillas that are completely free from preservatives and are made with only real food ingredients. For that reason, our tortillas MUST BE KEPT REFRIGERATED OR FROZEN.
FedEx 2-day shipping is FREE with all orders and is only available in the United States. In order to maintain freshness, we ship our tortillas Monday - Wednesday. Orders received after 12pm central time on Wednesday will be shipped the following week. We box our tortillas with ice packs and a recyclable insulated liner to keep them cold.
Best gluten free tortilla ever!
Love. Just wish they weren’t so expensive and available in local stores
Get Whole Foods to sell them!!!
We love love love your products, extremely disappointed when the store ran out of your siete chips
I require a special diet because I have MS so your products have been a blessing!
OH MY GOODNESS!! I love them so!
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Cassava & coconut Tortillas
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domain: food


The headlight adjustment screws on a 2001 Nissan Altima are located on the sides and back of the headlight assembly. They allow for small changes to be made to the position of the beams.
how to replace an altinator in a 2005 nissan altima
how do you replace the ac evaportator
It is located on the backside of the engine. Go to youtube and type in how to replace camshaft sensor on 2005 Nissan altima and it will show where it is and how to replace it, that is how I did my one.
You will need at least $300 to replace a radiator in Nissan Altima.
How do you replace a water pump on a 98 nissan altima?
I need to replace the back window of a 1999 Nissan Altima how do I do this
One headlight not working
How do you replace 2003 nissan maxima headlight?
Where is the fuel pump located on a 1996 Nissan Altima
My headlight is not working on the passengers side. Do I need to change out the headlight assembly or can I simply change out the bulb? My headlight is not working on the passengers side. Do I need to change out the headlight assembly or can I simply change out the bulb?
Check the headlight fuses located in the main fuse box. On a 2002 Nissan Altima the main fuse box is found inside the engine compartment.
My daughter has a 2002, and you must take it to the dealer, so we were told.
how to replace a heater core on a 2003 Nissan Altima 2.5
where is the catalytic converter located bank 2 for 97 Nissan altima
where is the fuel pump of nissan altima 2006 located
where is the ecm locate on a Nissan altima 2.5s 2002
pcv valve on nissan altima 2005
How do u replace the front axel on a 1997 nissan altima
Where is the neutral safety switch on a 1994 Nissan Altima?
where is the knock located on 2001 nissan altima 2.4
The Low Beam AND High Beam are in the same bulb. The procedure to change it will be in the owners manual.
The 1999 Nissan Ultima fuel filter is located in the fuel tank. The fuel filter is not visible and is very costly to replace.
Nope you can't


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The Past Ain't What It Used To Be... The first Command & Conquer received its last official update on the 21st of June, 1996. Since then, the game has been ported to Windows (as "Gold" version), and re-released in the big "The First Decade" collection pack, but has never received any more bug fixes. The C&C Gold Patch 1.06 project aims to bring this classic into the new millennium, by fixing the old bugs, supporting higher resolutions, and adding new modding and mapping possibilities. It also contains an addon-based language system, allowing anyone to create translation packs for the game.
As spotted by Kilkakon, the very last frame of the SSM launcher's turret graphics when its missiles are depleted was not correctly adapted to the player's colour.
Here you see the original, with yellow and grey splotches in it, and the fixed version, which makes it completely adapt to player-colour, as it does with all the other frames.

domain: game


text:
This website: www.decentearning.com using Email address: firstname.lastname@example.org and claiming to have an Minnesota registration as DECENT EARING corporate charter number 1Z-176, Formed under 867A on August 1, 2011 is publically operating as a fraudulent Scammer.
Program Stats. YOU TELL (ME) Why are they neglecting to pay legitimated withdrawal request as posted on their website requested to: email@example.com?
Started Aug 1, 2011, Running days 66 , Total accounts 2958
Total deposited $ 5,833,787.53
Total withdraw $ 1,142,768.37
Last update Oct 6, 2011
I have sent support Emails through their provided sources for at least 2 weeks without a response from anyone. There should be an investigation to remove this fraudulent Website and Email address to curtail or stop this fraudulent scam.
LATEST SCAMs posted :
Gain Reserve , JP-Daily, Pay You Money , Penny2Million, Global-Saving, City Winner, Amazing Forex Saving Capital, Dollarsmine, Safe Liberty, POIEM , Avangard Income, Decent Earning , Invest Net Group, Compact Fund ,
Program Stats. YOU TELL (ME) Why are they not paying withdrawal request exceeding 2 weeks?
Started : Aug 1, 2011 Running days 66 Total accounts 2958 Total deposited $ 5,833,787.53, Total withdraw $ 1,142,768.37 Last update Oct 6, 2011
I have sent support Emails through this website above for at least 2 weeks without a response from anyone. History: All of my transactions Deposit Earning Withdrawal Transfer from external processing Withdrawal request .
Type Amount Date: Withdrawal request $ 396.00 Sep-30-2011 03:34:04 AM EARNED TOTALS AND DEPOSITS DUE FROM MATURITIES REQUESTED WITHDRAWALS - NOT PAID - BUT DUE FROM INVESTMENT MATURITIES COMPLETED requested thru Alertpay $396.00 on 9/15/11 and also this same amount on 9/20/11 to Date not credited to my account Requested thru Alertpay $100.00 on 9/14/11 to date not credited to my Alertpay account ' Requested $853.00 on 9/24/11- to date not credited to my Alertpay account Requested thru Alertpay $1267.22 on 9/17/11 to date not paid or credited to my Alertpay account Requested thru AlertPay on 9/18/11 again this duplicate amount of $1267.22 to decenterning @ gmail.com - to date not paid or credited to Alertpay Requested thru Alertpay $119.00 on 9/18/11 to decenterning@gmaildcom - to date not paid or credited to my Alertpay account Requested duplicate amount of $853.00 thru firstname.lastname@example.org to date not paid or credited to alertpay requested $1,000.00 on 9/14 thru email@example.com to date not paid or credited to my Alertpay account
John Tucson, Arizona


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domain: sociology


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FOOTBALL IS BACK!
Everyone will want to add this decorative tiki totem to their garden or gameday decor! Inspired by the original Hawaiian style tiki totems, this polystone handpainted sports themed totem shows your team spirit in every element. From the mascot top
Everyone will want to add this decorative tiki totem to their garden or gameday decor! Inspired by the original Hawaiian style tiki totems, this polystone handpainted sports themed totem shows your team spirit in every element From the mascot top to the player base and everything in between, weÂ’re sure to have your friends and neighbors begging to know just where you got this unique product! Approximately 16" tall Made by Evergreen Enterprises
The fence sign is made of 3/8 inch hardboard and cut with dimension to give you the feel of a real fence. It has a routed hanging hole in the back. Many of the graphics use a retro white washed effect that can represent how long you've been a fan
The Halftime Cooler is a practical sized cooler for any outing. It is made with a heat-sealed, leak-proof lining to help keep your snacks or drinks cold. It has a zipper pocket on the front for dry storage. Use the handle on the lid or the detacha
These incredibly accurate 2" reproductions of the real helmets are a great collectible for any fan! Show off your favorite team, conference or collect them all!. Made by Riddell.
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Officially licensed NFL baby bib made of two ply soft polyester front and absorbent cotton terry back. It is decorated with a fun full color imprint. Finished with adjustable baby velcro. Printed in the USA with imported fabric. Made By Wincraft.<
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domain: hobby


by Kelley White, Whatcom Talk, March 20, 2023
Like rich sunshine, vivid and cheerful, the Calendula flower is as optimistic as it looks. Emily Mitchell, owner and founder of Em’s Herbals in Bellingham, has formulated the friendly and formidable flower into a salve and oil that both provide relief to some of the most vulnerable members in our community.
“We want to educate folks on what the benefits are and why this is such a great product,” says Mitchell. “We use certified organic Calendula flowers grown here in Whatcom County.”
Creating Calendula Salve and Oil
Mitchell’s process is wholesome with a mind for natural and organic ingredients. “We take the flower and infuse it into organic sunflower and jojoba oil for a minimum of three weeks,” Mitchell says. “There isn’t any heat applied that could damage the properties of the plant. It’s been expeller pressed and we hand press it so there’s no mechanical force used in the extraction process. What you get is a very simple, very effective, beautiful oil.”
With the oil, Mitchell creates a salve for those who prefer a more solid structure to the healing agent. “The salve is super simple, it only has four ingredients—five if you include the two oils we make the Calendula oil with,” Mitchell says. “The ingredients [for the salve] are infused Calendula oil, organic shea butter, organic beeswax, and organic coconut oil.” It’s formulated for folks with sensitive skin, and contains no hidden fragrances or preservatives. Mitchell’s Calendula salve is one of the most important creations from Calendula oil that Em’s Herbals offers. It has an incredible host of powerful properties and is astonishingly impactful for healing and pain management.
Mothers in Mind
The sustainable and clean Calendula products were originally formulated mainly for mothers and babies, a special interest of Mitchell’s, and for nursing mothers to heal things like chapped nipples. “You can also use [Calendula salve] for postpartum [baby care], and during labor for perineal massage,” says Mitchell. “When the baby is born, it’s great for helping remove meconium—the sticky, tar-like substance the baby passes as its first bowel movement.”
Mitchell was pleasantly surprised to find a multitude of other uses for the dazzling bloom. “You can use it on sunburn, and they’ve been doing studies on Calendula and dermatitis caused by radiation treatment for folks who have had breast cancer specifically,” says Mitchell. Women who have used Calendula salve and oil have fewer skin issues and don’t have to interrupt radiation treatment. “And the pain associated with the radiation treatment is reduced as compared to the other pharmaceutical ointments. I’ve heard this in testimonials from my customers.”
The positive effect Calendula salve has had on pain and healing during and after radiation treatments is a game changer for women dealing with breast cancer. Finding a natural and effective way to help cancer patients in pain is vital to Mitchell.
The salve can also come in handy with little ones who tend to find themselves with tiny scrapes and skinned knees.
“It’s got all these antioxidant properties, anthocyanins, and proanthocyanins, that give the flower that vibrant orange color,” Mitchell says. “And you can use the flower itself for so many different things. It has an affinity for epithelial tissue—skin tissue.” A tea can be applied to help cleanse and heal pink eye and other bacterial infections, like boils and athlete’s foot.
“It is just such an amazing plant,” says Mitchell. “It’s a gentle, ubiquitous, friendly, happy plant because it looks like sunshine, and it grows so easily. It’s just kind of like a friend for so many different reasons.”


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By SBS Australia
Brazil on Tuesday recorded its highest daily jump in new coronavirus cases since the start of the pandemic, with nearly 35,000 registered in 24 hours, the health ministry said.
The country, which has the second-highest number of coronavirus cases and deaths in the world, after the United States, reported 34,918 new cases and 1,282 new deaths in the past 24 hours.
That brought Brazil's total caseload to more than 923,000, and its death toll to 45,241.
There are grave fears over the impact of coronavirus in Brazil's indigenous populations.
Experts say under-testing in the country of 212 million people probably means the real figures are much higher.
The grim new record came as the World Health Organization's top official for the Americas again voiced concern over the situation in Brazil.
"Brazil has 23 percent of all cases and 21 percent of all deaths in our region. And we are not seeing transmission slowing down," Carissa Etienne, director of the Pan American Health Organization, told a news conference.
Brazil has struggled to set a strategy for dealing with the virus.
President Jair Bolsonaro, who has famously compared the virus to a "little flu," has clashed with state and local authorities over their use of stay-at-home measures to contain it.
The far-right leader argues the economic impact of such measures risks being worse than the virus itself, and has instead touted the drugs chloroquine and hydroxychloroquine as treatments, despite uncertainty about their effectiveness against COVID-19.
The post about “In just 24 hours, Brazil sets a grim new record with almost 35,000 new coronavirus cases" first appeared on the SBS Australia website.
To engage in helping and supporting our Latin American community impacted by the COVID-19 crisis, seek or share information, events, news, forums, and critical connection and collaboration opportunities during this time of mass isolation, join our community at COVID-19 Support Group.
Not yet a member? Get connected and be inspired by more incredible Latin American and Australian professionals. Join the growing Somos21 Community.

domain: medical


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Our custom Personalized appliqued Kisses-25 cent Longalls are cute, personalized clothes that everyone will adore.
Our custom made childrens clothing includes this longall with an appliqued Kisses 25 cents on navy blue cord. We can personalize this longall with your child's name or initial under the design. This custom longall is perfect for babies or toddlers.
Do you have twin or multipes? Our custom appliqued and monogrammed sets are perfect for siblings.
We can make a matching girls outfit.
WE CAN PLACE ANY OF OUR DESIGNS ON SHORTALLS, DRESSES, OR TSHIRTS. Please contact us for custom orders email@example.com

domain: design


Lives are being changed with a £30 million Government investment into Changing Places Toilets
It was delightful last week to see the Government announce a £30 million investment to provide Changing Places toilets in existing buildings in England. This is in addition to statutory guidance released in January which laid the groundwork for Changing Places toilets to be compulsory in certain new buildings. The combination of this investment and guidance is fantastic news for the estimated 250,000 people in the country who need these facilities to enable them to get out and about.
What is Changing Places and how did it all begin?
Many adults and children affected by cerebral palsy and other mobility challenges cannot use a standard accessible toilet. Parents are therefore left with little choice but to change their children on dirty toilet floors or in the back of vehicles. Some people simply choose not to leave home which, as many of us have found during the pandemic, is simply no way to live.
Fortunately this all began to change in 2005, when the Changing Places Consortium began working with local councils and a huge number of venues throughout the UK to introduce Changing Places toilets: properly equipped facilities to meet the requirements of those who need them. Each toilet has a height adjustable changing bench and hoist as well as enough space to accommodate both an individual and up to two carers.
How will the latest announcement change lives?
Robert Burley, Director of Campaigns at Muscular Dystrophy UK responded to the news:
“Today’s announcement of £30 million worth of funding to improve facilities in existing buildings is fantastic news for disabled people across England who need Changing Places toilets. Everyone has the right to use a public toilet when they need to, and these accessible toilets vastly improve a person’s independence and make planning days out much easier.”
Speaking to the BBC, Mrs Brisdion, mother of twins Erica and Hadley, said:
“It’s wonderful news – it offers freedom”.
Mrs Brisdion had been campaigning for better toilet facilities for seven years, since Hadley (who has cerebral palsy) was three. Mrs Brisdion said that Hadley faced the indignity of having to lay on the floor when he became too heavy for baby changing facilities.
Kerry Thompson, another Changing Places campaigner, is also delighted by the announcement:
“Knowing I have access to a Changing Places toilet lets me enjoy myself without having to worry about finding an accessible facility that can accommodate my needs. The additional funding from the government to improve facilities in existing buildings across England will give me and my husband the freedom that so many disabled people are desperate for.”
You can read about so many people’s experiences of how Changing Places has made a difference to their lives on their website.
As March marks Cerebral Palsy Awareness Month, this announcement could not have come at a better time.
I have the enormous privilege of working with families who have benefited hugely from Changing Places toilets and I share their joy in this much needed investment to tackle the exclusion that too may people experience when away from home.
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4-Wheel Disc Brakes ABS Adjustable Steering Wheel ALTERNATOR 220 AMPS AM/FM Stereo ASSIST STEPS NOT DESIRED OR ALTERNATE STEP DESIRED AUDIO SYSTEM CHEVROLET INFOTAINMENT SYSTEM WITH NAVIGATION AND 8" DIAGONAL COLOR TOUCH-SCREEN AM/FM STEREO with seek-and-scan and digital clock includes Bluetooth streaming audio for music and select phones; USB ports; auxiliary jack; voice-activated technology for radio and phone; and Shop with the ability to browse select and install apps to your vehicle. Apps include Pandora iHeartRadio The Weather Channel and more. Auto-Dimming Rearview Mirror Auxiliary Audio Input Back-Up Camera BED LINER SPRAY-ON Pickup box bed liner with bowtie logo. Liner is permanently bonded to the truck bed providing a water tight seal. The textured non-skid surface is black in color and robotically applied. Spray-on liner covers entire bed interior surface below side rails including tailgate front box top rail gauge hole plugs and lower tie down loops. BLACK Bluetooth Connection BOSE SOUND WITH 6 SPEAKER SYSTEM BUMPER FRONT BODY-COLOR BUMPER REAR BODY-COLOR CD Player Chrome Wheels Climate Control Cruise Control Daytime Running Lights DELETE UNIVERSAL HOME REMOTE/POWER REAR SLIDING WINDOW TRACKING CODE DOOR HANDLES BODY-COLOR Driver Adjustable Lumbar Driver Air Bag Driver Illuminated Vanity Mirror Driver Vanity Mirror DURAMAX PLUS PACKAGE includes (L5P) Duramax 6.6L Turbo-Diesel V8 engine (MW7) Allison 1000 6-speed automatic transmission (GT4) 3.73 rear axle ratio (K05) engine block heater and (K40) exhaust brake (Includes (IO6) 8" Diagonal Color Touch Navigation with Chevrolet Infotainment and LTZ Plus Package content. ENGINE DURAMAX 6.6L TURBO-DIESEL V8 B20-DIESEL COMPATIBLE (445 hp [332 kW] @ 2800 rpm 910 lb-ft of torque [1220 Nm] @ 1600 rpm) Includes capped fuel fill (K40) exhaust brake and (K05) engine block heater. ENGINE BLOCK HEATER EXHAUST BRAKE Floor Mats Fog Lamps Four Wheel Drive FRONT AND REAR BLACK BOWTIE FRONT AND REAR PARK ASSIST ULTRASONIC Front Head Air Bag Front Side Air Bag GRILLE BODY-COLOR with chrome bars GVWR 10 000 LBS. (4536 KG) HD Radio Heated Front Seat(s) Heated Mirrors HILL DESCENT CONTROL Integrated Turn Signal Mirrors JET BLACK LEATHER-APPOINTED FRONT SEAT TRIM Keyless Entry LAMPS SMOKED AMBER ROOF MARKER Leather Seats Leather Steering Wheel LED LIGHTING CARGO BOX WITH SWITCH ON CENTER SWITCH BANK LICENSE PLATE KIT FRONT Locking/Limited Slip Differential LPO ASSIST STEPS - 4" BLACK - ROUND LPO MOLDED SPLASH GUARDS BLACK
LPO REAR UNDER-SEAT STORAGE COMPOSITE STORAGE BIN LTZ PLUS PACKAGE includes (JF4) power adjustable pedals (UQA) Bose premium audio system (UVD) heated steering wheel and (UD5) Front and Rear Park Assist LTZ PREFERRED EQUIPMENT GROUP includes standard equipment MIDNIGHT EDITION includes (UD5) front and rear park assist (TC7) body-color grille with chrome bars (VB5) body-color front bumper (VT5) body-color rear bumper projector headlamps with body-color bezel (CGN) spray-on bedliner (RVS) 4" round Black tubular assist steps LPO (P3H) front and rear Black Bow Tie (RT4) 18" Black wheels (QF2) 18" aggressive tire tread and Black body-colored headlamp bezels (Includes (B86) body color bodyside moldings (D75) body color door handles and (DP6) body color mirror caps. MIRRORS CHROME OUTSIDE HEATED POWER-ADJUSTABLE VERTICAL TRAILERING MEMORY-EQUIPPED UPPER GLASS POWER-FOLDING AND MANUAL EXTENDING; Includes integrated turn signal indicators consisting of 51 square inch flat mirror surface positioned over a 24.5 square inch convex mirror surface with a common head and lower convex spotter glass (convex glass is not heated and not power-adjustable) and addition of auxiliary cargo lamp for backing up (helps to see trailer when backing up with a trailer) and amber auxiliary clearance lamp MOLDINGS BODYSIDE BODY COLOR MP3 Player Multi-Zone A/C PAINT SOLID Passenger Adjustable Lumbar Passenger Air Bag Passenger Illuminated Visor Mirror Passenger Vanity Mirror Pass-Through Rear Seat PEDALS POWER-ADJUSTABLE Power Door Locks Power Driver Seat Power Folding Mirrors Power Mirror(s) Power Passenger Seat Power Steering Power Windows Privacy Glass PROVISION FOR CAB ROOF-MOUNTED LAMP/BEACON provides an instrument panel-mounted switch and electrical wiring tucked beneath the headliner for a body upfitter to connect a body-mounted warning or emergency lamp REAR AXLE 3.73 RATIO Rear Bench Seat Rear Defrost Rear Head Air Bag Remote Engine Start Satellite Radio Seat Memory SEATS FRONT 40/20/40 LEATHER-APPOINTED SPLIT-BENCH 3-PASSENGER with (KA1) heated seat cushions and seat backs. Includes 10-way power driver and front passenger seat adjusters including driver/front passenger power recline driver/front passenger power lumbar 2-position driver memory and adjustable outboard head restraints. (STD) Security System Sliding Rear Window SNOW PLOW PREP PACKAGE includes power feed for backup and roof emergency light (KW5) 220-amp alternator with gas or diesel engine forward lamp wiring harness (TRW) provision for cab roof mounted lamp/beacon (NZZ) underbody shields and Heavy-Duty front-springs Split Bench Seat Stability Control STEERING WHEEL HEATED LEATHER WRAPPED WITH AUDIO AND CRUISE CONTROLS Steering Wheel Audio Controls Telematics Tire Pressure Monitor Tires - Front All-Season TIRES LT275/65R18E 123/120Q MAXIMUM TRACTION BLACKWALL Goodyear Wrangler DuraTrac. Aggressive tread may result in a higher level of noise while driving. Routine tire rotations are strongly recommended. Tires - Rear All-Season Tow Hitch Tow Hooks Traction Control TRAILER BRAKE CONTROLLER INTEGRATED TRANSMISSION ALLISON 1000 6-SPEED AUTOMATIC ELECTRONICALLY CONTROLLED with overdrive electronic engine grade braking and tow/haul mode UNDERBODY SHIELD FRAME-MOUNTED SHIELDS includes front underbody shield starting behind front bumper and running to first cross-member protecting front underbody oil pan differential case and transfer case Universal Garage Door Opener WHEEL 18" X 8" (45.7 CM X 20.3 CM) FULL-SIZE STEEL SPARE. WHEELS 18" (45.7 CM) BLACK ALUMINUM includes 18" x 8" (45.7 cm x 20.3 cm) steel spare wheel. WiFi Hotspot Z71 PACKAGE OFF-ROAD includes twin tube Rancho brand shocks (JHD) Hill Descent Control (NZZ) underbody shields. Also includes brushed metal Z71 door sill plate unique Z71 gauge cluster unique finish interior trim plates unique lower bumper appearance Z71 emblem in grille Black mesh grille with 2 bar dark chrome inserts and Z71 pickup box decals
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Students Pledge News – On August 17, anti-fee hike student protestors were brutally attacked by the police administration, backed by the ruling political party. This heinous incident happened inside the Haldibari College in Cooch Behar district on August 17 when students were peacefully protesting under the leadership of AIDSO against fee hike. Demanding exemplary punishment of the accused police officer a procession reached the SP office in a peaceful manner, suddenly police again attacked the unarmed student activists. The students were pulled by their clothes, verbally abused, and mercilessly lathi-charged. Girl activists were also not spared. Girl students were even attacked by male police! The police dragged the students and AIDSO workers into the car in a very aggressive manner.
False cases have been framed against 13 students under multiple non-bailable sections including terrorist activities, harassment of women. The tragedy is, even the court has ordered to send students to jail for 10 days!
Sourav Ghosh, General Secretary of AIDSO (All India Democratic Students’ Organisation) said – “AIDSO appeals to all the democratic minded citizens of the country, to speak up against this heinous & demonic attack by the police and implicating the anti-fee hike protestors under non-bailable cases. The people of India have deep respect for the movements led by AIDSO because they are always legitimate and dignified. In the long history of students’ movement in our country, the AIDSO is held in high esteem because it always fights against injustice with justified demands and never indulges in any unethical practices. Its deplorable that in order dissuade the students from joining the anti-fee hike protest, the government has falsely implicated the students under terrorist activities. The police administration has registered multiple non-bailable cases against our workers for indecent behaviour on women and creating terror. This police complaint is aimed, encouraged and supported by the ruling party. This role of the administration towards a just democratic movement is nothing but state repression. This role of the police administration and ruthless attack on the democratic students’ movement, is being condemned by the people of entire state. We are appealing to all students, teachers, and guardians, people of all professions to join the anti-fee hike students’ movement and also protest the police repression in Coochbehar. We are appealing to your conscience and raise your voice against this brutality”

domain: law


Name him “The Late Late Present” stopper.
The stunts rocketed previous sleight of hand into WTF territory. In his pièce de résistance, involving an iPhone and a pockets, Flom even pulled off what seems to be time journey. It’s that good.
Flom is a contestant on “The World’s Finest,” the brand new expertise competitors that Corden hosts. Final week the present attracted modest scores in its Wednesday time slot, competing partially in opposition to Fox’s “The Masked Singer,” based on The Hollywood Reporter.
Nearly as good as Flom is, he can’t make “The Masked Singer” disappear.
Watch the clip above.
- This text initially appeared on HuffPost.


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Meet the awe-inspiring "Sunlight Seraph," a Huge Celestial being that will dazzle your players in your tabletop roleplaying games like Dungeons & Dragons™. This magnificent creature possesses four magnificent wings, adding an air of majesty to its presence. Wielding powerful Angelic blades, the Sunlight Seraph is a formidable warrior, ready to defend the forces of good.
In addition to its melee prowess, the Sunlight Seraph is capable of casting powerful spells like Sunbeam and Solar Explosion, turning the tide of battle in favor of light and justice. This celestial guardian is the embodiment of divine power, bringing an element of sacred light to your gaming sessions.
Prepare your players for an encounter with the awe-inspiring Sunlight Seraph, a being whose divine power and radiant abilities will create unforgettable moments in your campaign.
This is a massive 32mm scale miniature that stands over 6.5 inches tall.
Figure Dimensions: Width 153mm, Depth 88mm, Height 166mm
- This model may be available in different sizes to suit your individual needs. If you need a model in a size other than what is offered, please contact us and we can discuss your options.
- This model may come in separate pieces and require assembly. We recommend using cyanoacrylate glue or 5 minute epoxy to assemble. We use Starbond Medium Cyanoacrylate. For added strength, pins can be used to assist in connecting some of the parts together. Gap filler can be used to fill any gaps and smooth out connection seams. A good product for this is Green Stuff Sculpting Putty.
- Resin printing requires the use of supports. We remove the supports and perform basic clean up the support marks from the model, prior to performing the final cure. While we strive to remove all supports used for printing there may be some artifacts that we miss. This is sold as a kit and will require some cleanup and sanding on your part.
- Models are made to order, we have a 1-2 week processing time. This time helps ensure we do not rush and provide the highest quality product. Some orders may take longer to produce due to the size or quantity of items ordered. We will do our best to get your order out in a timely manner. If you have concerns on production time, please contact us to discuss your timeline requirements.
We offer free standard shipping on orders of $60 or more within the United States.
International orders over $130 USD ship for free.
We do our best to ensure your product will arrive to you without damage, but sometimes things can get a little beat up during shipping. If you receive a damaged item, contact us right away and we will work with you to get you a replacement sent out to you.


Jack Tayba isn’t one to rest on his laurels. When the VET Engineering student produced a working model of a jet engine from 3D-printed plastic parts back in June it was an impressive enough achievement. But Jack has taken his fascination for engines a step further, having just completed a larger, more powerful, metal jet engine entirely hand-cut and assembled.
“This project wasn’t for assessment, rather an opportunity to test my ability,” Jack said. “That’s the only way to keep learning and improving, so I keep pushing myself.”
With another year of VET Engineering to look forward to Jack has big plans for his next project… though he’s keeping them under wraps for now.
“Let’s just say I have a couple of BIG projects planned for 2019.”
We’ll definitely keep you posted!


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Welcome to our extensive guide on online huay lottery play! In this write-up, we will certainly dig right into the globe of online lotto play, giving you expert guidance, methods, as well as pointers to raise your chances of striking the pot.
Online Lottery Play: Releasing the Adventure of Prize Searching
Online lottery play has revolutionized the method people participate in lottery video games. With just a couple of clicks, you can get in several lottos from worldwide and stand a possibility to win life-changing sums of cash. The ease and accessibility of online lottery play have made it exceptionally preferred amongst gamers worldwide.
Exactly How to Start with Online Lotto Play?
Beginning with online lotto play is a wind. Adhere to these straightforward steps to embark on your thrilling lottery journey:
1. Pick a Credible Online Lottery System: Look for a trusted and licensed on-the-internet lotto system that provides a wide range of lotto games to play. Ensure that the platform has safe repayment options and a clear payment system.
2. Join and Create an Account: Register on the online lotto platform by supplying your details as well as producing a distinct username and password. This will certainly give you accessibility to the system’s functionalities and also features.
3. Surf and Select Lotteries: Discover the extensive range of lottery games readily available on the system. Review the summaries, and reward structures, and also attract dates to make an educated decision.
4. Pick Your Numbers: Once you have chosen a lotto game, pick your fortunate numbers or choose a quick choice option, where the system produces arbitrary numbers for you.
5. Acquisition Your Tickets: Finalize your ticket acquisition by picking the number of attracts you desire to take part in as well as confirming your repayment. Keep a duplicate of your ticket for a referral.
6. Wait for the Outcomes: Relax, relax, as well as wait for the draw results. Most online lotto systems inform champions using e-mail or give the option to examine outcomes straight on their internet site.
Online Lottery Play: Tips as well as Strategies for Success
While online lotto play is greatly a game of chance, there are several methods you can utilize to boost your odds of winning. Right here are some specialist pointers to boost your online lottery experience:
1. Study as well as Pick the Right Lotteries
Not all lottos are produced equivalent. Research study various lottos, examine their chances, reward frameworks, and also ticket costs. By selecting lottery games with desirable chances as well as sensible ticket prices, you can maximize your chances of winning.
2. Join a Distribute or Lotto Game Swimming Pool
Consider joining a distribute or lotto swimming pool to boost your winning possibility. In a distribute, you pool your money with other gamers, permitting you to buy a bigger number of tickets. This dramatically raises your odds of winning without breaking the financial institution.
3. Play Consistently
When it comes to on-line lotto play, uniformity is crucial. Set an allocate yourself and play regularly to raise your opportunities of hitting the jackpot. Bear in mind, the more tickets you have, the greater the likelihood of winning.
4. Make Use Of Number Selection Methods
Some players rely on certain number selection strategies, such as choosing birthday celebrations, lucky numbers, or patterns on the ticket. While these approaches don’t ensure a win, they add an element of customization to your gameplay as well as make it a lot more enjoyable.
5. Make Use Of Advertisings as well as Incentives
Many on-line lottery platforms use discount rates, incentives, as well as promotions to attract brand-new players as well as maintain existing ones. Watch out for such offers, as they can provide extra worth as well as boost your chances of winning.
Frequently Asked Questions (Frequently Asked Questions).
1. Can I play lotto games from various countries online?
Definitely! One of the significant advantages of on-line lotto play is the capability to participate in lottery games from around the world. You can play lotto games from the convenience of your residence without being limited by geographical limits.
2. Are online lottery platforms safe and safeguard?
Yes, respectable online lotto platforms utilize innovative safety procedures to ensure the safety and security as well as personal privacy of their individuals. Look for systems that are certified and controlled by reputable authorities to guarantee a safe gaming experience.
3. Exactly how are jackpots paid out in online lotteries play?
The process of claiming winnings might vary depending on the lotto game and the system you’ve played. Most of the times, small winnings are credited straight to your account, while larger rewards may call for added confirmation and a hand-operated payout process.
4. Can I play on the internet lotto on my mobile phone?
Absolutely! Most on-line lottery platforms offer mobile-friendly websites or committed mobile apps, enabling you to use your smart device or tablet. This supplies flexibility and also ease, enabling you to take part in lotto games on the go.
5. Is on the internet lotteries play lawful?
On-line lottery play is legal in lots of territories. However, it’s essential to check the neighborhood regulations as well as laws regarding on the internet gambling in your nation of home prior to joining any type of lotto games.
6. What are the probabilities of winning the pot?
The probabilities of winning the prize differ from lottery game to lotto. Usually, the chances are quite challenging, but that’s what makes winning the reward such an exhilarating experience. Study the probabilities of each lottery you play to manage your assumptions.
You are currently geared up with the expertise and also techniques to make the most out of your on-line lotto play. Online lotteries play offers a amazing and hassle-free way to delight in the adventure of jackpot hunting.
In this post, we will dig right into the world of on the internet lotto play, providing you with expert recommendations, methods, and also suggestions to boost your opportunities of striking the jackpot. On the internet lottery play has actually changed the method individuals take part in lottery game video games. Pick a Respectable Online Lottery Platform: Look for a relied on as well as certified on-line lottery platform that uses a vast selection of lotteries to play. One of the major benefits of online lottery play is the capacity to participate in lottery games from around the globe. Many on the internet lottery platforms use mobile-friendly internet sites or devoted mobile applications, enabling you to play on your mobile phone or tablet.


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The Love Market
By Carol Mason
McArthur & Company
Unlike the current hip and glib and surely unsustainable perusal of high-octane media studies – wherein a veritable barrage of the young and (preferably) beautiful embark upon such solipsistic career paths as self-absorption ad celebrity infinitum – were romantic novel writing to be a tad more cathedral in approach, a tiny modicum of melioristic thought, might, somewhere along the line, be allowed to truly prevail.
As is, a plethora of literary romance continues to run amok amid a quintessential slipstream of lust, triggered utopia; wherein assorted petals of both impossibility and implausibility continue to reign supreme beneath the darkness of the duvet. Or should that read the duvet of the darkness? Either way, it’s pain, pathos and the pre-ordained complexity of denial, or cash, candour and the much sought after, liberal sprinkling of sparkling Darcy dust (to go bro).
So roll over Marriage Guidance Counselling and tell cunnilingus the news.
Even if chick lit isn’t the be all and the literary end all, its prognosis has oft been known to bequeath consolation for those in need of a little tenderness. And by way of forensic, fideistic observation, Carol Mason has once again succeeded in bequeathing just that.
By way of the ‘’politics of disenchantment,’’ The Love Market follows the trials and sticky tribulations of protagonist Celine Lewis; who, having already gazed into her deep dark truthful mirror by the time we have even reached the end of chapter one (‘’the weights and measures of a marriage; we know things but we choose not to think about them’’), cums exceedingly clean with both herself, her family and her prospective dream lover, Patrick.
Written with as much familiarity that our own soaring acknowledgement will allow, Mason touches on a menagerie of issues throughout the novel. Among them, the inevitable and anguish induced, trying familial bones of contention, which we are all at some time or another, compelled to deal with in our lives.
In Chapter Two for instance, the authoress wrestles with the complexity of simmering guilt regarding Celine’s awkward, and not particularly tactile relationship with her father: ‘’Sometimes it’s hard to forget, and difficult to forgive, but time has a way of ensuring you become bored with your own battle […], and there comes a time in all our lives when we have to start making amends before we exit this life with one too many regrets on our conscience.’’
Having transformed an otherwise hopeless and somewhat linear tale of marital woe into a concord of regal possibility, Carol Mason has hit upon a number of nerves simultaneously. In and of itself, this may partially explain why The Love Market – which is already a really cool title – could just as easily have been called what Mason refers to as ‘’The Slow Unbeguiling.’’
A candid, classy and contagious read.


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Young people across Britain are rushing to open the new type of tax-free savings account which promises to help them on to the property ladder.
The new LISAs give savers aged 18 to 40 the chance to get a 25 per cent kickback from the Government for every pound that they deposit.
After the launch on Thursday April 6, Money Saving Expert Martin Lewis described the LISAs as a 'no-brainer’ for almost every first-time buyer.
Here is a breakdown of who is currently offering Lifetime ISAs
But he said: “The launch of the new LISA (Lifetime ISA) looks like a bit of a damp squib, with only a few providers offering them.
“Yet don't ignore it. After all, £1,000 of annual free cash is not to be sneezed at - and for first-time buyers, delay could cost.”
Major banks are still reviewing the new rules and regulations and there are only three providers that offer the new accounts at the moment – Hargreaves Lansdown, Nutmeg and the Share Centre.
While just a few providers are offering a Lifetime ISA at the moment, the long term attraction for younger people to use a LISA to get onto the housing ladder is clear
Danny Cox, a chartered financial planner at Hargreaves Lansdown, said: “The early birds have flocked to the new Lifetime ISA in large numbers already, which is testament to the appeal of this new addition to the ISA family.
“While just a few providers are offering a Lifetime ISA at the moment, the long term attraction for younger people to use a LISA to get onto the housing ladder is clear.”
Skipton Building Society is set to offer LISAs from June, with more banks expected to jump on board later in the tax year.
Lifetime ISAs offer a 25 per cent kickback on every pound saved
Who is offering a Lifetime ISA?
Here is a breakdown of who has Lifetime ISAs on offer and who will join later in the year, according to consumer advice group Which?
On offer now
The Share Centre
Lifetime ISAs can be opened between the ages of 18 and 40
From June 2017
Skipton Building Society
Later in the tax year
These new savings accounts aim to help first time house buyers
Reviewing rules and guidance
Bank of Scotland


A highly questionable rumor from East Asia on Thursday claims Apple will replace the venerable Space Gray colorway with a new "Deep Blue" shade when it launches the next-generation iPhone this fall.
According to Japanese website Mac Otakara, which has in the past provided accurate predictions, a Chinese supplier revealed Apple's "iPhone 7" series will be available in dark blue, silver, gold and rose gold options. Further, it is "highly likely" that Space Gray will be nixed from the lineup, the report said.
The source also noted "iPhone 7" is slated to use the same LCD glass as current versions.
Apple introduced Space Gray alongside the iPhone 5s in 2013. The metallic color, a lighter shade of Apple's black clad aluminum, joined a lineup of silver and gold models, which has since been expanded to include rose gold.
Apple is expected to debut a next-generation handset this fall. Rumors and parts leaks point to a largely unchanged chassis design (with or without 3.5mm headphone jack) packing updated internals like an "A10" SoC, a 256GB storage tier and, for the larger "iPhone 7 Plus" variant, a dual-lens camera system. The phablet version might also come with 3GB of RAM for advanced photo and video processing and Apple's new Smart Connector, though the latter is far from confirmed.
The most recent rumors suggest LG Innotek will be responsible for supplying a majority of the dual-camera modules bound for "iPhone 7 Plus," taking over for longtime supplier Sony.


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The third aircraft in Boeing’s new B737 Max series follows the industry trend of fuel efficiency.
Boeing, the world’s largest aerospace company, has debuted its new 737 Max-7 aircraft at its factory in Renton, Washington on Monday.
Highly anticipated by the aviation industry, the smallest of Boeing’s 737 Max family is a single-aisle aircraft that can carry a maximum of 72 passengers.
Small but mighty, the aircraft follows the industry trend of fuel efficiency, with 18 percent lower fuel costs per seat compared to its predecessor, the 737-700. Yet, it can fly up to 3,850 nautical miles, which is the most in the 737 Max family.
Flight tests are expected to begin in the weeks to come, with the aircraft expected to enter service starting with Southwest Airlines in 2019.
Keith Leverkuhn, vice president and general manager of the B737 Max program said “For our airline customers serving airports at high altitudes or remote locations, the Max 7 is the ideal complement to their fleet.”
More information here.


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BET bromodomain inhibition suppresses Th17-mediated pathology
http://constpharma.wpengine.com/wp-content/uploads/2013/10/J-Exp-Med-2013-Mele-jem-201303761.pdfConstellation Pharmaceuticals Announces New Preclinical Data on Novel BET Bromodomain Inhibitors Published in the Journal of Experimental Medicine
Results Demonstrate Therapeutic Benefit of BET Inhibition in Autoimmune Disease Models
CAMBRIDGE, Mass. – October 8, 2013 – Constellation Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company in the field of epigenetics, today announced the publication of a study in the The Journal of Experimental Medicine demonstrating that small molecule inhibitors selectively targeting BET bromodomains can suppress T helper 17 (TH17) differentiation and TH17-mediated pathology in models of autoimmune diseases. The paper appears in the online early edition of J Exp Med published the week of October 7, 2013.
During the last decade, researchers have uncovered the importance of TH17 cells as an integral part of the immune system that protects the human body from infections. However, this research has also shown that, when pathologically activated, these cells can attack multiple organs in the body and trigger autoimmune diseases such as multiple sclerosis, rheumatoid arthritis and psoriasis. Because of the important roles that TH17 cells play in both normal and dysregulated immune function, many academic, biotech and pharmaceutical laboratories have research programs devoted to targeting TH17 cells.
“In our study, we show that BET bromodomains are important in the process that differentiates naïve T cells into TH17 cells, by controlling the expression of several key cytokines, such as IL-21 and IL-17. These effects result in remarkable efficacy in experimental models of multiple sclerosis and rheumatoid arthritis. The picture that emerges, together with work from other groups, is that BET bromodomains control the immune response in very profound ways,” said Jose Lora, Ph.D., executive director of preclinical sciences at Constellation and lead author of the study.
“The work which implicates BET bromodomains as key controllers of T cell differentiation into TH17 cells is of fundamental interest in the field, but also has potential importance for patients suffering from TH17 cell-driven diseases. Our commitment at Constellation is to translate these promising discoveries into novel therapeutic approaches for patients,” commented Jim Audia, Ph.D., chief scientific officer at Constellation.
About Constellation Pharmaceuticals
Constellation Pharmaceuticals leverages insights from the rapidly expanding field of epigenetics to discover and develop small molecule therapeutics for the treatment of cancer, inflammatory/immunologic disorders and other diseases. Research at Constellation and by others has shown that abnormal epigenetic regulation of gene expression contributes to many different
diseases. The company’s innovative product discovery engine targets both the enzymes that modify the dynamic structure of chromatin and other proteins that interact with chromatin to control gene expression. Restoration of normal gene expression through chromatin modulation by highly selective and specific inhibitors promises to be a powerful avenue for the development of important new medicines against a broad range of diseases. Constellation’s efforts in epigenetics are supported in part through a research collaboration with Genentech. For more information, please visit the company's website at constpharma.wpengine.com.
Pure Communications, Inc.


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Field and Laboratory Investigations of Organic Photochemistry on Urban Surfaces
Abstract:In polluted urban environments, windows and building surfaces rapidly become coated with a complex film of chemicals, which enhances the dry deposition of particles and the partitioning of semi-volatile organic species to the surface. Despite its high surface-to-volume ratio and direct exposure to sunlight, few studies have directly investigated the role that this “urban film” may play in promoting the photooxidative processing of semi-volatile organics contained within it. The present study represents a comprehensive field- and laboratory-based investigation of the film-phase photochemistry of polycyclic aromatic hydrocarbons (PAH), here used as proxies for light-absorbing semi-volatile organics present within the film.
Urban film sampling was conducted using a custom-built three-stage sampler housing, which was deployed in a central, high-traffic area in Leipzig, Germany. The sampler itself employs small glass beads as surrogate window surfaces and is designed such that only its uppermost stage is exposed to sunlight. Each stage is subdivided into 16 compartments, which allows for the study of film formation and evolution.
In the first phase of the study, the role of urban film as a photochemical sink for reactive organic species was determined by measuring total film PAH content and PAH abundance ratios as a function of atmospheric exposure time under both light and dark conditions.
In the second, more general, phase of the study, the organic and inorganic composition of collected film samples was compared to that of co-located PM10 samples, and differences between the two sample types were used to gain insight into the relative importance of heterogeneous photochemical oxidation within the particle and film phases.
In the third phase of the study, film samples grown under dark conditions were exposed to gas-phase ozone in an atmospheric-pressure flat-bed reactor, and the kinetics of ozone-induced PAH loss were studied under both dark and illuminated conditions. Since previous work from our group has shown that the heterogeneous photooxidation of PAH occurs at different rates and via different mechanisms depending on its immediate environment, this in situ study of PAH reactivity provides substantial insight into the photochemical processing of this class of compounds in urban environments.


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The Toyo Ito Museum. All photos: Iwan Baan
General wisdom holds that canonization is an honor best conferred upon by third parties, who, through their objectivity and credentials, may initiate the process unhampered by the subject's personal prejudices. Clearly, general wisdom does not apply to great artists and architects--and, it might be added, tyrants--who have, at least since the Renaissance, singlehandedly forged their owned myths of genius. From Alberti to Le Corbusier, El Greco to Picasso, each has elevated their own image with every work they produced; so that to ask, for example, what monument Frank Lloyd Wright would have built for himself is, perhaps, misguided, considering the fact that everything Wright ever built was first and foremost an act of narcissistic self-aggrandizement, fuel for the Wright-the-greatest-architect-ever fire. Which makes it all the more surprising (and, in this case, excusable) that the decidedly self-effacing Toyo Ito has built a new museum solely dedicated to his architectural work.
The recently-opened Toyo Ito Architecture Museum on Omishima, a small island that dots Japan’s Seto Inland Sea, is comprised of two structures: the Steel Hut, a trapezoidal configuration of black steel that rises from a hillcrest overlooking the ocean, and the nearby Silver Hut, a humble vaulted pavilion that recalls the elegance of the lightwight and prefabricated structures of Japan and Europe's post-war period. The formal language of the Steel Hut, which has its roots in the geometric cosmology of Buckminster Fuller's space frames and dymaxion maps, Louis Kahn's City Tower proposal, Moshe Safdie's post-collegiate megastructural projects, not to mention Ito's own early work, rebukes the flowing abstract fields that characterize the current Japanese architectural scene.
That isn't to say that Ito's museum is out of place in Japan's architectural culture--it's decidely Japanese, with its polyhedral massing channeling the country's technofuturist eccentricities, its illustrious Metabolist past, and even, its former shipbuilding dominance. Ito himself described the museum as a "sea-worthy vessel. Like a ship embarking from the port city of Imabari with a cargo of dreams of architecture for the future, the museum is setting sail on a new voyage into the unknown."
The museum is a poignant affirmation of Ito's celebrated career. His most famous buildings, including the perforated Mikimoto Ginza tower and the fluid-like Taichung Opera House, now under construction, are all present--represented in miniature and in other forms--collected together in the architectural equivalent of a warm embrace.


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SAN DIEGO, Aug. 24, 2011 /PRNewswire/ -- Awarepoint Corporation, the leading provider of real-time location system (RTLS) solutions for healthcare, announced today that it has secured $27 million in Series F financing. New investor Kleiner Perkins Caufield & Byers (KPCB) led the round of financing, which also included participation from new investor Top Tier Capital Partners, and existing investors Cardinal Partners, Venrock, and Jafco Ventures. Awarepoint will use the capital to fuel the company's next stage of growth and drive further adoption of its pioneering aware360Platform.
Awarepoint's aware360Suite of RTLS-enabled solutions help hospital clients reduce hard operating costs, boost top-line revenues, and increase compliance management and patient satisfaction. Clients have deployed Awarepoint's patented technology and software platforms in the areas of asset management & tracking, rental reduction, temperature monitoring, hand hygiene, emergency, and perioperative departmental workflow and throughput, and enterprise patient tracking and workflow automation.
"Awarepoint delivers innovative technology and software solutions to healthcare providers enabling them to uniquely address escalating costs and compliance challenges, which is why KPCB is so excited to be an investor in the company," said KPCB partner Dana Mead.
"The current investors are thrilled to welcome KPCB to the investor group and board of directors of Awarepoint. We continue to be excited about the growth prospects of Awarepoint and are pleased with the strong execution of the company this past year," said Brandon Hull, g