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The Figure shows pathways for melanoma metastasis. Vemurafenibis an oral, highly selective inhibitor of the oncogenic V600E mutant BRAF kinase, which showed promising results in early clinical studies. In a dose-finding phase I trial, 11 of 16 patients (68%) with BRAF-mutated metastatic melanoma achieved a partial response (PR) and 4 patients had minor responses, leading to a progression-free survival (PFS) of 8 to 9 months.1 A dose-extension phase I trial with 32 patients demonstrated an objective response rate of 81% (2 complete responses [CRs], 24 PRs). The median PFS among these patients was more than 7 months. Vemurafenib was generally well tolerated, with the most common side effects being rash, photosensitivity, arthralgia, and nausea. Of note, 31% of patients developed grade 3 squamous cell carcinoma (SCC), keratoacanthoma (KA) type. The median time to the appearance of a cutaneous SCC was 8 weeks with no reported involvement of other organs. Treatment with vemurafenib was not interrupted by the appearance of these skin lesions, and the majority of them were resected.2
The phase II trial of vemurafenib 960 mg orally twice daily administered to patients with previously treated melanoma (BRIM 2) demonstrated an overall survival (OS) of 16.9 months, which is unprecedented in melanoma trials.3 The phase III trial (BRIM 3) comparing vemurafenib 960 mg orally twice daily to dacarbazine 1000 mg/m2 IV in untreated patients with BRAF V600E-mutant metastatic melanoma demonstrated improvement in PFS and OS for patients receiving vemurafenib. Due to the significant advantage of vemurafenib, the trial was amended to allow patients randomized to dacarbazine to crossover to the vemurafenib arm.4
The data from the previously treated patients in the phase II trials mirrored the results of the untreated patients in the phase III trial, confirming that order of therapy does not impact response rate or survival.3 The robust data generated in this phase III trial was the basis for FDA approval of vemurafenib in patients with BRAF V600E-mutated metastatic melanoma in 2011.4
Dabrafenib is another oral, highly potent, and selective Dabrafenib is another oral, highly potent, and selective BRAF V600E/K/D inhibitor that has shown similar effectiveness to vemurafenib. In a phase I/II study, treatment with dabrafenib 150 mg orally twice daily led to a decrease in FDG-PET metabolic uptake, with 11 of 14 patients (79%) with melanoma showing a decrease from baseline (range, 5% to 100%) and 18 of 30 patients (60%) demonstrating a greater than 20% tumor decrease by RECIST at first restaging (8-9 weeks).5 Most of the side effects, including low-grade nausea, pyrexia, vomiting, fatigue, and headaches, were predominantly transient and mild in severity, making dabrafenib very well tolerated. Similar to vemurafenib, patients also experienced increased rates of low-grade SCC lesions; however, this side effect was found to be much less prevalent with dabrafenib. A phase III study of dabrafenib as initial therapy in patients with unresectable stage III or metastatic disease demonstrated improved PFS compared with chemotherapy.6 Although confounded by crossover, this study was later updated to show improved OS with dabrafenib, 18.2 months versus 15.6 months.7 Following these results, the FDA added dabrafenib to the melanoma treatment repertoire in 2013.
One of the factors that initially set dabrafenib apart from vemurafenib was the extensive data regarding its effects on brain metastases. Dabrafenib was first found to have activity in a phase I dose escalation trial, in which a small subgroup of 10 patients with brain metastases had a significant reduction in the size of their brain lesions.8 This was further supported by a phase II multicenter, open-label trial that evaluated dabrafenib therapy in 172 patients with melanoma with both previously treated and untreated brain metastases. Dabrafenib therapy resulted in a 31% and 39% response rate, respectively.9 Recently, similar outcomes were found with vemurafenib. A small open-label pilot study involving 24 patients with previously treated brain metastases showed a PR in 10 patients and stable disease in 9 patients with vemurafenib therapy.10
Trametinib is a potent and selective inhibitor of the MEK1/2 enzymes, which are found downstream from BRAF. A phase I clinical trial resulted in a response rate greater than 70% in patients with advanced melanoma with known BRAF mutations, including 1 patient who was previously treated with vemurafenib.11 A phase II study further supported the activity of trametinib in patients with BRAF-mutated disease, with the greatest effect observed in patients who were BRAFinhibitor naïve.12 This was followed by a phase III open-label trial that compared chemotherapy (dacarbazine or paclitaxel) with trametinib and found improved median PFS and OS in the trametinib group; median PFS was 4.8 months in the trametinib group versus 1.5 months in the chemotherapy group.13 The study revealed that even though 74% of patients had some tumor regression with trametinib, only 22% had a response that met RECIST. Although these results are not as robust as with BRAF inhibitors, it still provides significant benefit to patients when compared with previous chemotherapy treatment options. Similar to other targeted therapies, trametinib is well tolerated; however, the side effect profile is different from BRAF inhibitors and includes papulopustular rash, diarrhea, and peripheral edema.
Emerging data at the time of these studies disappointingly revealed that the dramatic responses to single-agent BRAF inhibition were of limited duration. Research has shown none of the mechanisms of resistance to be through the MAPK pathway, making the idea of dual blockade an intuitive option to pursue. Dabrafenib and trametinib were combined in a phase I dose escalation trial, and the phase II recommended dosages of these medications were identified at 150 mg orally twice daily for dabrafenib and 2 mg orally daily for trametinib.14
The phase II trial published in 2012 demonstrated that this combination provided improved PFS and increased the proportion of patients alive at 1 year compared with dabrafenib monotherapy.15 The subsequent phase III trial published in The New England Journal of Medicine in 2014 additionally demonstrated improved PFS in the combination group of 9.3 months versus 8.8 months. In addition to increased PFS, combination therapy significantly decreased the development of SCC.16 There are, however, a small group of patients who will achieve complete or partial responses that are sustained for greater than 12 months. While these prolonged responses do occur, we cannot predict which patients will derive this benefit de novo. This long-term follow-up data of the phase I and II trials was recently presented at the 2014 American Society of Clinical Oncology Annual Meeting, with updated results showing a median OS of 23.8 months with the combination treatment.25
Concurrently, trials evaluating vemurafenib combined with cobimetinib were being conducted. A phase III trial published in The New England Journal of Medicine evaluated 495 patients who were randomly assigned to either the combination group or single-agent vemurafenib group. Results not only showed improved PFS, but revealed an OS benefit in the combination group. There was an 81% survival rate at 9 months in the combination group versus 73% in the single-agent group. Although the combination did show increased grade 3 adverse events, similar to previous combination studies, there was a significant decrease in SCC rates.17 Tables 1 and 2 detail single-agent versus dual-agent efficacy and toxicity.
Although targeting the MAPK pathway is a promising new therapeutic approach for the treatment of melanoma, and treatment with selective BRAF and MEK inhibitors can induce high response rates, the limited duration of these responses in most patients, most likely because of emerging resistance to these inhibitors, represent a significant clinical challenge. Molecular redundancy, in part due to the existence of RAF isoforms and signaling through alternative oncogenic pathways such as PI3K/AKT/mTOR pathway,18,19 receptor tyrosine kinase (PDGFRβ)-dependent pathway,20 and COT (MAP3K8),21 may provide the melanoma cells escape mechanisms to specific pathway inhibitors, and underscore their ability to adapt to pharmacologic challenges. In preclinical models, it has been reported that acquired resistance of melanoma cells to the BRAF inhibitors was associated with rebound activation of the RAF/ MEK/ERK pathway.19 In line with this finding, activating signals to downstream MEK/ERK has been shown to switch to ARAF22 or CRAF22,23 via N-RAS upregulation20 to overcome the effect of BRAF inhibition. Moreover, the majority of melanoma cells harboring the BRAFV600E mutation retained the wild-type BRAF allele, which could be rescued from the effects of BRAF knock-down by extracellular growth factors such as basic fibroblast growth factor, hepatocyte growth factor, or endothelin-1.24 These mechanisms of resistance may not apply to immunotherapy with checkpoint inhibitors, which may lead to less frequent responses, but can be of longer duration compared with BRAF and MEK inhibition.
Continued research exploring multi-targeted inhibitors and immunotherapy is currently under way. These trials will explore important questions of drug sequencing and scheduling.
Despite the majority of significant responses lasting several months, there is a subset of patients who experience what we have termed the "Lazarus Syndrome." I have coined this term because Lazarus was raised from the dead simply by God calling his name, and these drugs resurrect deathly ill patients with melanoma this quickly. It is an unbelievable feeling for the patient, their family, and the medical staff--a sense of vindication occurs, and patients and families stop planning funerals and start planning vacations. Unfortunately, some of the most miraculous responses in deathly ill patients are also the shortest-lived, with most responses lasting no more than months.
A 26-year-old Hispanic female with BRAF-mutated metastatic melanoma status post-4 cycles of ipilimumab with no response and rapid progression of disease presented to the clinic via ambulance transport on a stretcher. Physical examination demonstrated an extremely cachectic young woman in moderate distress, with multiple massive subcutaneous masses over trunk and extremities, severe abdominal distention due to liver metastases, bilateral 4+ pitting, and weeping lower-extremity edema and shallow breathing due to bilateral pleural effusions.
She was treated with vemurafenib 960 mg orally twice daily and was instructed to return for follow-up in 1 week.
Her response was dramatic. One week after initiating vemurafenib, her leg edema resolved, her abdomen was no longer distended, and she was eating normally. She walked into the clinic 1 week later modeling her size 4 jeans with a pair of platform shoes! It was a wonderfully emotional day for the patient, family, and staff.
She did extremely well for 8 weeks until she called to report a new "lump" on the right side of her neck, which appeared "overnight." It was the beginning of the end. Within 2 weeks, she became severely debilitated and bedridden with recurrent abdominal distention and leg edema. She died 10 weeks after that dramatic response.
Another such case was that of a 57-year-old male who developed a large necrotic mass on his right posterior shoulder. A biopsy was nondiagnostic due to the extensive necrosis. He had a distant history of stage I melanoma 12 years prior. Magnetic resonance imaging (MRI) demonstrated extensive necrotic tumors in the right shoulder, liver, lungs, subcutaneous nodes, and brain. His brain lesions were treated with gamma knife surgery. The pathology returned, identifying his tumor as a BRAF-mutated melanoma. On the same day the information regarding his pathology was revealed, he was hospitalized for progressive shortness of breath that required CPAP ventilation. Within 72 hours of starting vemurafenib, he was discharged from the ICU and was sent home 24 hours later. Within 1 week, he also had a notable improvement in the large, right-shoulder mass.
He did well for approximately 9 weeks, but required dose delays and dose reductions due to liver function test elevations. Reimaging demonstrated stable treated brain metastases and 75% reduction in his disease burden. Since he was having difficulty tolerating the targeted therapy but had dramatically improved clinically and was neurologically stable, his therapy was changed to immunotherapy with ipilumumab. He received 1 dose of ipilimumab and 14 days later developed mental status changes and headaches. MRI revealed innumerable, hemorrhagic brain metastases and leptomeningeal disease. Systemic scans also documented rapid progression in visceral organs.
He was immediately started on dabrafenib and trametinib, but had no response to treatment and became severely debilitated from the rapid progression of disease complicated by his wholebrain radiation therapy. He died 12 weeks after the initiation of dual-targeted therapy.
These cases represent the "roller coaster" that some patients and their families endure with this disease. They prepare for death, then a "miracle drug" salvages them and gives them hope that survival is possible. Unfortunately, far too often and far too quickly, this hope is crushed with the rapid progression of disease and demise of the patient. The mental anguish that patients, families, and healthcare professionals experience during this time needs to be acknowledged. This roller coaster of hope deceives patients, family members, and health care providers into believing that "everything is going to be okay." This period of hope must be tempered with the reality that it may only be a transient hiatus and that the patient is going to die from their disease. It is an area where psychosocial support can have a tremendous impact.
We must always keep in mind our limitations as well as the limitations of these drugs. These are life-changing drugs whose impact has been felt worldwide, but now we are faced with the challenge to make these responses durable. We have to approach our patients by hoping for the best, but always being prepared for the worst. Most important, we have to continue to enroll patients onto clinical trials so that we can continue to improve on our successes and work to resolve the "Lazarus Syndrome," and provide all of our patients with long-term durable responses. We have made huge strides in combating this disease, but more work still needs to be done.
Affiliations: Lena Furmark, MD, is from the Division of Medical Oncology, Department of Medicine, and Anna C. Pavlick, MD, is from the Division of Medical Oncology, Departments of Dermatology and Medicine, New York University Perlmutter Cancer Center, New York City.
Disclosures: Drs Furmark and Pavlick have no relevant conflicts of interest to disclose.
Address correspondence to: Anna C. Pavlick, MD, NYU Perlmutter Cancer Center, 160 East 34th Street, 9th Floor, New York, NY 10016. Phone:212-731-5431; fax: 212-731-6017; email: [email protected].
- Flaherty K, Puzanov I, Sosman J, et. al. Phase I study of PLX4032: proof of concept for V600E BRAF mutation as a therapeutic target in human cancer. J Clin Oncol. 2009;27(15s;abstr 9000).
- Flaherty KT, Puzanov I, Kim KB, et al. Inhibition of mutated, activated BRAF in metastatic melanoma, activated BRAF in metastatic melanoma. N Engl J Med. 2010;363:809-819.
- Sosman JA, Kim KB, Schuchter L, et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med 2012;366(8):707-714.
- Chapman PB, Hauschild A, Robert C, et al. BRIM-3 study group. Improved survival with vemurafenib in melanoma patients with BRAF V600E mutations. N Engl J Med. 2011;364(26):2507-2516.
- Kefford R, Arkenau H, Brown MP, et al. Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors. J Clin Oncol. 2010;28(15s; abstr 8503).
- Hauschild A, Grob J, Demidov LV, et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicenter, open-label, phase 3 randomized controlled trial. Lancet. 2012;380:358-365.
- Hauschild A, Grob J, Demidov LV, et al. An update on BREAK-3, a phase III, randomized trial: dabrafenib (DAB) versus dacarbazine (DTIC) in patients with BRAF V600E-positive mutation metastatic melanoma (MM). J Clin Oncol. 2013;31(suppl;abstr 9013).
- Falchook GS, Long GV, Kurzrock R, et al. Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. Lancet. 2012;379:1893-1901.
- Long GV, Trefzer U, Davies MA, et al. Dabrafenib in patients with Val600Glu or Val600lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicenter, open-label, phase 2 trial. Lancet Oncol. 2012;13:1087-1095.
- Dummer R, Goldinger SM, Turtschi CP, et al. Vemurafenib in patients with BRAF (V600) mutation-positive melanoma with symptomatic brain metastases: final results of an open-label pilot study. Eur J Cancer. 2014;50(3):611-621.
- Infante JR, Fecher LA, Nallapareddy S, et al. Safety and efficacy results from the first-in-human study of the oral MEK 1/2 inhibitor GSK 1120212. J Clin Oncol. 2010;28(15s;abstr 2503).
- Kim KB, Kefford R, Pavlick AC, et al. Phase II study of MEK1/MEK2 inhibitor trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor.J ClinOncol. 2013;31(4):482-489.
- Flaherty, KT, Robert C, Hersey P, et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med. 2012;367:107-114.
- Infante JR, Falchook GS, Lawrence DP, et al. Phase I/ II study to assess safety, pharmacokinetics, and efficacy of the oral MEK1/2 inhibitor GSK1120212 dosed in combination with the oral BRAF inhibitor GSK2118436. J Clin Oncol. 2011;29(suppl;abstr 8503).
- Flaherty KT, Infante JR, Daud A, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med. 2012;367:1694-1703.
- Long GV, Stroyakovskiy H, Gogas E, et al. Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma. N Engl J Med. 2014;371:1877-1888.
- Larkin J, Ascierto P, Dreno B, et al. Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. N Engl J Med. 2014;371:1867-1876.
- Jiang CC, Lai F, Thorne RF, et al. MEK-independent survival of BRAF V600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720. Clin Cancer Res. 2011;17(4):721-730.
- Paraiso KH, Fedorenko IV, Cantini LP, et al. Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy. Br J Cancer. 2010;102(12):1724-1730.
- Nazarian R, Shi H, Wang Q, et al. Melanomas acquire resistance to B-RAF (V600E) inhibition by RTK or N-RAS upregulation. Nature. 2010;468(7326):973-977.
- Johannessen CM, Boehm JS, Kim SY, et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 2010;468(7326)968-972.
- Villanueva J, Vultur A, Lee JT, et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell. 2010;18(6): 683-695.
- Montagut C, Sharma SV, Shioda T, et al.Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008;68(12):4853-4861.
- Christensen C, Guldberg P. Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V600E) B-RAF. Oncogene. 2005;24(41):6292-6302
- Flaherty K, Daud A, Weber JS, et al. Updated overall survival (OS) for BRF113220, a phase 1-2 study of dabrafenib (D) alone versus combined dabrafenib and trametinib (D+T) in pts with BRAF V600 mutation-positive (+) metastatic melanoma (MM). J Clin Oncol. 2014;32(suppl 5s; abstr 9010).


Following the landslide victory of centre-right party Fidesz in elections held on 25 April, which gave it a constitutional majority, Hungary will reduce the number of MPs by almost half and will reduce the number of its constituencies by a similar proportion, MEP József Szájer told journalists on 11 May.
The victory of European People's Party-affiliated Fidesz is "extraordinary" and amounts to a most serious change to Hungary's political system, said Szájer, who is vice-chairman of the EPP. He compared the outcome to the political backlash in Italy fifteen years ago, when the corrupt party system of that time had in his words changed completely.
"I heard colleagues joking that a country where two thirds of MPs are from the same party is not a democracy. Some people even compare it with Vladimir Putin's regime. But I tell them Putin never had to fight with the opposition to win an election," Szájer said.
He insisted that Fidesz is a "mainstream" centre-right party "in the vanguard" of European centre-right politics, strongly rejecting suggestions made by some foreign media that Fidesz is linked to far-right force Jobbik, which obtained 47 seats in parliament.
Szájer said that following hearings in parliament, Prime Minister Viktor Orban was determined to put in place a small government of eight ministers, which he said was "maybe the smallest in Europe".
Then, he said, the next step would be the "considerable reduction of local government," roughly halving the system and "hopefully" halving the costs.
"Hungary has 3,000 independent constituencies, which means many mayors, many deputies and so on. We want to use it as a demonstration to the general public that after the disastrous years of spending, politicians are starting hard measures against themselves," the MEP said.
Parliament will face a similar scenario, he said, with a law or a resolution to be adopted "very soon" on "cutting the parliament by half". He added said the size of a parliament in a country of 10 million like Hungary should be around 200, roughly about half the size of the present 386-seat parliament.
The next thing, he said, was to launch a tax-reduction programme, as his country in his terms was at a disadvantage compared to other countries in the region such as Slovakia or Romania, which have introduced low corporate taxes.
Then, the government must address what he described as "an emotional issue": Hungarian minorities living in neighbouring countries. On the model of similar legislation in Romania vis-à-vis Moldova, he said ethnic Hungarians who could prove their "attachment" to Hungary would have easier access to citizenship.
Regarding the Hungarian EU Presidency, he said that water, water management, Danube cooperation, regional cooperation and boosting the Europe 2020 strategy would be its highlights.
Askled by EURACTIV if Hungary would ban foreigners from buying arable land indefinitely, as Fidesz said during the campaign (EURACTIV 01/04/10), Szájer said that this was indeed a sensitive question, and negotiations would be held with the European Commission to prolong the ban.
Hungary's 2004 accession treaty barred land purchases by foreigners until 2011 in an effort to prevent wealthy European investors from buying up large chunks of arable land in the poor new member state. Similar transition clauses were negotiated by other ex-communist newcomers, such as Poland and the Czech Republic.
Szájer said that what should be expected is a "package deal" with gives and takes, adding that whoever is in power would press for a similar deal, as the price of land had not changed.
"We want to avoid speculation," he insisted.


Federal Student Aid Changes Proposed
The House Committee on Education and the Workforce has released a proposal to significantly change how the U.S. government distributes student aid. Announced last week as the Promoting Real Opportunity, Success and Prosperity through Education Reform Act, the plan involves deregulating and restricting oversight of portions of federal aid programs. Proposed changes include simplifying student aid options, eliminating the public service loan forgiveness program, and changing the federal work-study program by distributing money to colleges based on student need. Learn more about the proposed changes to federal student aid is available on the Inside Higher Ed website.
FAFSA Mobile App Announced
In its efforts to update the federal student aid system, the Department of Education is planning to make the Free Application for Federal Student Aid (“FAFSA”) available via a mobile application. Office of Federal Student Aid Chief Operating Officer A. Wayne Johnson said the app would make it easier for students to file for federal aid and provide a modernized experience throughout the application process. Johnson also noted that the app could perform many of the functions that student loan servicers can provide borrowers via the web and telephone. The app will likely arrive in April. More on the future FAFSA mobile app is available. Read More.
Online FAFSA Tool Temporarily Down for Months
An online tool used by students to help them complete the Free Application for Federal Student Aid (“FAFSA”) might be unavailable for several months. In a joint statement last week, the Department of Education and Internal Revenue Service said the tool will be down until security protections are implemented. The added security measures are aimed to protect the taxpayer data of those who submit an application. Students should expect the tool to be back at the start of the next FAFSA season on October 1. More on the FAFSA online tool is available on the Inside Higher Ed website.
FAFSA Changes Draw Mixed Responses
The Department of Education has announced that starting with the 2017-18 academic year, the Free Application for Federal Student Aid (“FAFSA”) will be released months earlier and the application deadline will be pushed up to October 1. In addition to the new schedule, FAFSA applications will automatically use the most recent federal tax data, which is a shift from having applicants estimate their family’s income data. While higher education groups believe the FAFSA changes will lead to a more simplified financial aid process, college access advocates feel the earlier deadlines could make it difficult for low-income students to receive aid.. Read More.


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Welcome to the East Grand Forks Schools Human Resources page. Our District employs approximately 300 people who provide an educational environment that supports and encourages the success of our approximately 1900 students. East Grand Forks Schools offers challenging and rewarding careers, good salary and benefit packages, and a work environment that supports staff and student success.
We are continually seeking enthusiastic individuals who are motivated to help us achieve our goal of attaining the highest levels of student success.
The East Grand Forks Public School District is an Equal Opportunity Affirmative Action Educator and Employer and is in compliance with Title IX of the Education Amendments of 1972.
No person in the United States shall, on the basis of sex, be excluded from participation in, be denied the benefits of, or be subjected to discrimination under any educational program or activity receiving Federal financial assistance.
-Title IX of the Education Amendments of 1972
The East Grand Forks Public Schools prohibits any form of harassment and violence on the basis of race, color, creed, religion, national origin, sex, age, marital status, familial status, status with regard to public assistance, sexual orientation, including gender identity or expression, or disability. Sexual harassment that creates a hostile environment, including sexual assault and other forms of sexual misconduct, is a form of discrimination prohibited by Title IX.
Title IX Officer: Bryan Hackbarth
School Board Policy 522: Title IX Sex Nondiscrimination Policy, Grievance Procedure and Process

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MUSCATINE, Iowa–For the first time since 2017, Muscatine High School’s Fire Island Robotics team competed in the First Robotics World Championship. A playing field like no other, approximately 20 local students tested their engineering and teamwork skills at a whole new level April 20-23 in Houston, Texas.
Fire Island earned the opportunity to compete in the First Robotics World Championship by winning the Engineering Inspiration Award at the Minnesota 10,000 Lakes Regional in early April. In order for a team to advance, they must earn first or second place at the regional competition or earn a Chairman, Rookie of the Year, or Engineering Inspiration Award. The Engineering Inspiration award honors teams that provide outstanding community outreach. Throughout the year, members of Fire Island Robotics have worked with students at Jefferson Elementary School to utilize their NAO Robot and visited area schools and nursing homes to play interactive games using an Obie projector.
About 10 times the size of the regional competitions Fire Island usually competes in, the World Championship pitted 450 teams from around the world against each other to see who could create and operate their robot most effectively. Teams competed in divisions of 75 teams to work towards the goal of making the finals. Though Fire Island did not make it to the finals this year, they earned 22nd in their division, putting them in about the top third of competitors overall. “I still think we were pretty successful,” said senior Maya Theobald, who has competed with Fire Island for three years.
For senior Emilio Bobay, who has participated on the Fire Island Robotics team for five years, going to the World Championship his senior year gave him a sense of closure and of pride, as he got to help prepare younger students to remain successful in future years. “I enjoyed the fact it was my last year and I got to bring my team to Worlds and teach them the scope of things,” he said.
Ethan Mattes, a junior who has competed with Fire Island Robotics for the past six years, found the World Championship an excellent opportunity to get ideas for how to keep the team competitive in the years to come. “I think we learned a lot about how teams go to Worlds consistently, and we have a lot of members who want to put in a lot of hours,” he observed.
First year Fire Island participants Cesar Garrido and Drake Minder agreed with Ethan that their trip to the World Championship prepared them for future growth. “Since we went to Worlds, I think more people are interested and motivated to stay in it,” stated Cesar.
Drake, who asserted he had, “no doubt,” that Fire Island would return to the World Championship, also pointed out that this motivation will likely translate into summer practices, giving the team an edge for next year’s competition season.
Because a trip to the First Robotics Championship comes with expenses, the team turned to the community to help them defray the costs. The Black Pearl Café decided to pitch in, creating a special Fire Island drink that brought in $2,000 for the team.

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Does it ever get better????
14 June 2021 at 11:15 pm #55314
I have just joined this forum as I feel so helpless and alone and I suppose I’m looking for some moral support.
I’ve been separated from my husband now for about 15 months. Very messily for the first 9 months with police having to be involved numerous times. He was very controlling and manipulative eventually breaking my nose about 6 months before our eventual final split. By this point emotionally I was done with him but too scares to actually leave.
Fastforwad almost 2 years and I’ve left, living alone with my children in a tiny rented house. Having lost my full time job last year due to covid, I am now working part time whilst claiming UC.
Everyone keeps telling me how far I’ve come but I feel worse off than ever. I’m so desperately unhappy all of the time. I hate that I love in acting home that isn’t my own. I can’t afford to buy as I don’t earn anywhere near enough in high priced area I live. I now do a part time job I hate and the relationship I was having after my break up has now ended leaving me feeling more sad and alone than ever. I feel like I can’t see an end to all this unhappiness and feel like I have gone backwards financially.15 June 2021 at 8:00 am #55319
Just wanting to reach out and send some virtual love your way. I’m not sure if it gets better yet, too early to tell for me yet, but everyone around me and those that have been here before tell me it does so we have to trust them ey? I imagine one day you will just find yourself pretty happy and OK with the situation you are in.
Sending love and hoping you can be gentle with yourself x15 June 2021 at 2:36 pm #55328
Thank you for the reply Sunray.
Think what bothers me most is after more than a year I feel no better off and frankly most days I feel worse than ever. I hate the idea of starting my life again at 34. Makes me feel so sad and a failure.
I hope you can get there as well xx15 June 2021 at 7:17 pm #55331
Hi Eve, you have lost alot and you are grieving that, this sounds completely normal to me. Remember that we have gone through lockdown which has in some ways out a pause on any growth or improvement some of would have hoped for. I so believe we won’t go back to what we have had so things can only improve even if there is lots of stops, starts and delays to normality again.
The house situation – yes I know that feeling. I used to own a flat and then became unwell after separation from my ex and I lost everything it felt, my finances, a career, my health, my home and it eventually resulted in living with my mum which has been very difficult. Mentally though I feel ok and hopeful and have for through. How would you feel about applying for social housing? I know it isn’t the dream but I have seen so many really nice HA homes and people I know having lived in some great places. It is so much more secure. Why not just get yourself registered so you feel you are taking some control.
Could you afford private counselling? Many will give a discount for those struggling / on benefits. I cannot advocate this enough. Counselling saved me and is what has kept me going and smiling despite losing so much eventually. After all you have been through I believe this would be a lifeline for you; a woman ideally.
Can you handle the thought of working on a better job, looking at socialising in any way you can with your kids without looking for a new relationship. You are so vulnerable right now you could attract the wrong sort of guys and also it will hurt so much more if it goes wrong whilst you are dealing with so much else.
Things really can get better, there is light at the end of the tunnel as these restricted continue to lift and we have some normality again.18 June 2021 at 1:28 am #55432
Maybe don’t think of it as ‘starting life again at 34’….gosh starting life again?! No thank you in my opinion.I prefer to see it as a journey.Yep there’s ups and downs but it’s like that with anything and hopefully we have learned from past experiences.It’s all just a load of experiences we go through to make us who we are🤔.They say great women are not born they’re made.I like to see myself as one,in the making….😆 It’s the polish that brings out the shine and all that.It’s all true as long as we don’t get too bitter and twisted along the way I suppose.
And please don’t say you’re a failure! I get a bit offended bc then you’re kind of branding all of us single parents failures and we’re totally not.When life’s a struggle and we fight to keep our heads above water and keep doing that day after day we are actually heroes!! It’s easy to be happy when you have it on a silver platter.
Good luck and💗

domain: psychology


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Austral Hepaticae 48. Goebelobryum Grolle (Acrobolbaceae)
Engel, John J.; Glenny, David
Goebelobryum vermiculare sp. nov. is added to the genus Goebelobryum described by Grolle (1962) for two species, G. unguiculatum (Hook. f. & Taylor) Grolle of New Zealand and Australia, and G. grossitextum (Steph.) Grolle, endemic to Western Australia. The new species has been previously included within G. unguiculatum, and occurs in New Zealand and Australia. In Australia it is confined to Tasmania, while in New Zealand it occurs in both North, South, and Chatham islands, on nutrient-poor soils that support heathlands and rushlands that are periodically burnt and contain species adapted to recovery after burning. Goebelobryum vermiculare appears to be such a fire-adapted species.

domain: biology


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- Mayoral Charity extravaganza in aid of raising funds for schoolchildren
By Andrew Atkinson EXCLUSIVE
A Mayoral Charity extravaganza is being planned for later in the year in aid of raising funds for schoolchildren in Los Montesinos, Alicante, headlined by the Costa Blanca’s leading artiste Stevie Spit BEM.
Los Montesinos Mayor Jose Manuel Butron is to assist in the organisation of the charity gala, staged at The Oasis Bar and Restaurant in La Herrada, Los Montesinos, in liaison with proprietor Graham Stephen and supported by The Leader newspaper.
The charity event will take place after the current Phases of the easing of COVID-19 restrictions imposed by the Spanish Government.
A confirmed date will be announced later in the year, during October onwards.
Speaking on behalf of the charity event, Mayor Jose Butron, who has chosen monies raised to go towards helping children, said: “I will assist with the charity event – later in the year – once we know that it is safe to do so, following the coronavirus.”
On his choice of charity, Mayor Butron said: “The charity event funds raised will go towards buying tablets for children at school, so that the most disadvantaged can follow the classes of their teachers.”
Speaking to The Leader, Graham Stephen said: “The charity event is a ‘thank you’ fundraiser for The Mayor’s choice of charity.
“The event is on behalf of Mayor Butron’s help and guidance that he and his colleagues have given us during COVID-19.
“And for all the extra work Mayor Butron had to undertake for the people of Los Montesinos, at this time.”
Graham added: “Obviously the date, or dates, are to be confirmed later. After the current Phases of restrictions that are in place.
“At present the charity event is being looked at to take place over two days, involving our Agency Entertainment.
“There will also be something for the children, all undertaken by adhering to the guidelines at that time.
“It will be amazing – Stevie Spit will headline the show. I am looking forward to the organisation of the charity event and getting back to normal. A party for everyone.”
Drag Queen, singer-comedian Stevie Spit BEM said: “I am happy to help in the Mayor’s charity cause.”
Stevie, awarded the BEM in the 2020 New Year’s honours list, added: “I am committed and look forward to the future event, amid the uncertainty surrounding future plans, due to COVID-19. I’m in.”
THE OASIS BAR and RESTAURANT La Herrada, Los Montesinos re-opened May 12. Opening hours: 10am until close.
Food available, from BREAKFAST 10am, through until 1pm. Afternoon SNACKS available. EVENING menu from 6pm. Terrace tables only to eat here.
TAKEAWAY available everyday and DELIVERY, only on Wednesday and Friday evening or SUNDAY lunch. Please pre-order deliveries and takeaways. To order please WhatsApp 645409436 or Telephone +44 77138 5537.


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domain: entertainment


Editor, The Spotlight:
The Town of Bethlehem has recently taken the initiative to propose a local law that will foster the integration of the town Highway Department and the Department of Public Works. This concept has long been under consideration and the time to make this change is no at hand.
As a former commissioner of public works for the Town of Bethlehem and a professional engineer, I gained significant insight into the missions of both departments. They have many common elements, similar workforces and work closely together on many town activities. During my tenure as commissioner, a task force carefully examined the potential to merge the two departments. One of the common elements was a unified call center to handle the numerous calls received by separate call units. This specific functionality was implemented and as a result the call center was established in the DPW offices. The savings were in the order of $30,000 a year. It also freed up one person to perform other tasks that were in need of attention. This happened over seven years ago which means that the town has already saved in excess of $200,000.
There have been several reviews of the possible merger and each time quantified savings were developed. The latest study has identified a number of possible cost savings as well as improved efficiencies that will be possible. Reviews of other municipal governments and county governments have shown the benefits of combining these two departments. I believe that additional opportunities will be become possible when the two departments have merged and cross pollination of ideas is fostered.
The merger of these two departments will create a low walled work environment that allows people, tasks and a common mission statement to be articulated to all employees. This is no different than what has occurred in the private sector with quantifiable results. I urge town residents vote in favor of this change and allow the town to develop a management structure that will deliver an efficient, effective single organization to support Town of Bethlehem residents.
Oliver Holmes, Delmar


Sustainability Champions - Story Map
While the City works to reduce its own energy consumption, there are many Monona residents who have installed sustainability projects in their own homes. To celebrate the success of Monona's residents and to educate people about the many different kinds of sustainability projects out there, the Sustainability Committee created the interactive Sustainability Champions map.
The Sustainability Committee is working with MG21 students and Monona's Community Media department to interview residents about the sustainable features of their home and share their stories. These interviews were recorded and integrated into the interactive map below. Explore the map and learn about what sustainability looks like in Monona!
Would you like to be a Sustainability Champion?
If you have a sustainable project (like solar panels, a rain garden, a composting system, etc.) that you would like featured on the map, please contact Brad Bruun (firstname.lastname@example.org)


The husband of Michaela McAreavey is to receive a five-figure sum in damages over the Irish Daily Mail’s publication of CCTV stills of another couple arguing in their honeymoon hotel.
A lawyer for the newspaper also issued an unreserved apology to John McAreavey for using the "potentially misleading images".
Mr McAreavey sued over an article that appeared during the trial of two men later acquitted of murdering his wife.
Michaela McAreavey, 27, the daughter of Tyrone Gaelic football team manager Mickey Harte, was found strangled in the newlyweds' honeymoon suite at the Legends Hotel in Mauritius in January 2011.
Her husband was at the High Court in Belfast today to hear confirmation of the resolution to his defamation action.
Lawyer Michael Kealey, for the defendants Associated Newspapers (Ireland) Ltd, said in a statement: "An article published in the 15 June 2012 edition of the Irish Daily Mail included stills taken from CCTV footage showing what the newspaper described as an 'arguing couple', and which were presented in such a way as to potentially infer that they may have been John McAreavey and his late wife, Michaela.
"In fact, the footage was of a German couple, as has been unequivocally accepted by the authorities in Mauritius."
Mr Kealey continued: "The defendant acknowledges that these potentially misleading images were published at an extremely difficult and traumatic time for John McAreavey and caused him significant distress.
"The defendant unreservedly apologises to John McAreavey and very much regrets the distress caused by the publication of this material.
"The Irish Daily Mail is committed to supporting John McAreavey in his fight to ensure that those who were responsible for the brutal murder of his beloved Michaela are held to account for their actions."
Sources close to the case also disclosed that a "substantial five-figure sum" is to be paid out in damages.
Outside the court Mr McAreavey's lawyer, Paul Tweed of Johnsons law firm, said: "The Irish Daily Mail's publication of a photograph of John McAreavey, interspersed within a series of CCTV stills of a German couple arguing, could not have been published at a more difficult and sensitive time which criminal proceedings had been ongoing in Mauritius.
"Although John is satisfied with this categoric and comprehensive apology before the court this morning, together with the payment of appropriate damages and his legal costs, the article should not have been published in the first place."
"However, John remains very grateful for the support he has received from the media, and he hopes that this will continue with a view to ensuring that absolutely no stone is left unturned in bringing those responsible for Michaela's murder to justice."


Viaduct's loss is 520's gain, in reshuffling of funds
Published 10:00 pm, Friday, January 26, 2007
The project to replace the Evergreen Point Bridge across Lake Washington came out a big winner Friday as a regional transportation agency reshuffled its ambitious program of proposed highway work in King, Pierce and Snohomish counties.
The agency -- the Regional Transportation Investment District -- will ask voters in November to approve taxes to finance its entire $8.5 billion spending proposal. The package will be linked on the ballot to a planned $11 billion expansion of Sound Transit's light rail network, which would require its own tax support (amounts are in current dollars). Both measures must pass in the agencies' service areas for either to take effect.
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The RTID executive board voted unanimously to increase its contribution to the replacement of the Evergreen Point Bridge, which carries state Route 520 between Seattle and the Eastside. The increase, from $800 million to $1.1 billion, should allow expansion of the bridge from its current four lanes to six, board member Reagan Dunn said.
"This is a project that not only benefits the Eastside, it benefits Seattle," Dunn said. "It is a vital link for jobs and housing."
Dunn, a Bellevue Republican, is one of three King County Council members on the board.
The full cost of a six-lane bridge has been pegged at $5.3 billion. Gov. Chris Gregoire supports the project and the state is expected to pick up most of the cost, with tolls covering some of the rest.
The decision to pony up more for the bridge came as RTID reshaped its initial list of proposed projects, drafted a year ago. Estimated construction costs have increased significantly since, and the price for the program rose from $7.2 billion to $8.8 billion. Although RTID's tax power hasn't changed, it plans to rely more on borrowing instead of a pay-as-you-go approach, yielding a net gain even after interest payments, agency staffers said.
The biggest cut was eliminating an $800 million contribution to a six-lane, double-decked tunnel to replace part of the Alaskan Way Viaduct. That project was the darling of Mayor Greg Nickels, but it foundered because of high costs and opposition by Gregoire and key legislators. Nickels is pushing now for a cheaper four-lane tunnel and the city has told RTID it doesn't need the money.
The $800 million has been "reprogrammed," RTID project manager Kjris Lund said, with $200 million going to the 520 bridge and the rest into several Seattle projects. They include widening Mercer Street at its intersection with Interstate 5, new traffic lanes and ramps for the Spokane Street Viaduct, replacing the South Park Bridge, bus ramps for I-5 and a vehicle overpass above the train tracks at South Lander Street. Some of the redirected spending will finance Metro rapid transit service on state Route 99 into Shoreline.
The other $100 million extra for the bridge came from reducing spending in the initial plan on Interstate 405 on the Eastside, Lund said. As part of that, a new Coal Creek interchange in South Bellevue has been dropped from the program.
Among projects scaled back were an overhaul of the I-405/state Route 167 interchange, the extension of state Route 509 to I-5 south of Sea-Tac Airport and reconstruction of the U.S. Route 2 trestle in Snohomish County. Added was an I-5 offramp in Tacoma.
The proposed RTID taxes are 0.8 percent of the motor vehicle license fee, amounting to about $80 per $10,000 of assessed value, and a 0.1 percent sales tax, or 1 cent on a $10 purchase.
The Legislature created the RTID in 2002 to collect taxes for transportation projects. The agency's district, for taxes and elections, includes the most heavily urbanized areas of King, Pierce and south Snohomish counties, running along the eastern shore of Puget Sound.
Sound Transit's district is almost identical. Its proposed 0.5 percent sales tax would cost a typical household $125 a year.


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GameStop was, at one time, one of the premier names in gaming. Some say it still is. Yet as gaming becomes more sophisticated, gaming systems continue to evolve, and streaming becomes a cornerstone of the gaming experience, GameStop is in trouble.
Perhaps best-known as the company that innovated the buy-sell-trade model in 2000, GameStop was owned by Barnes & Noble before being spun-off in 2004. By 2008, it had achieved a market cap of some $6 billion. It was the only entity to offer video games on Amazon at one point, bought out a competitor, and things were rosy.
GameStop’s stock experienced a second wind following the financial crisis, almost reaching its previous high of $62 but falling short at $56.
Since then, GameStop’s stock has lost 90 percent of its value.
GameStop is getting killed in the purchase of new games via digital platforms and streaming. To that end, it’s the same problem every retailer has been facing the past 10 years: digital purchases vs. brick-and-mortar.
Yet in addition to losing market share in that manner, for those gamers who want the hard copy, there is a lot of competition. Amazon and Best Buy are the primary competitors to contend with, and that’s like dealing with an 800-pound gorilla and its 300-pound cousin.
Used game sales used to be a big winner for GameStop. But in the past few years, that trend has changed because of the new game situation. People who purchase new games via a digital platform don’t have hard copies to sell back to GameStop, and therefore there are fewer used games to sell.
Even worse, used games provide GameStop with the highest margins.
This is all showing up in company financials. Overall revenues have been declining; even in years when it rises, the cost of revenue rises as well, as do other expenses.
GameStop’s core business is dying. The market doesn’t have confidence in the company’s future. There have also been several CEOs that can’t quite figure out how to turn the company around.
The good news is that GameStop is still throwing off positive free cash flow , although that amount has declined from $483 million in FY15 to only $232 million last year.
GameStop will likely have to suspend or eliminate the $157 million in annual dividends it pays to stay afloat. Fortunately, it also has $1.624 billion of cash on hand and $471 million in long-term debt, so bankruptcy is not in the cards.
What about a buyout? GameStop tried to find one last year but couldn’t, leaving it swinging in the wind.
The only likely solution is a buyout or a turnaround, by an entity that can figure out how to transform GameStop the way Best Buy was transformed. The latter went from being a retailer to a stop-in for store-within-a-store support, much like the Apple Genius Bar.


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No. 5 Wichita State faces struggling Tulsa (Jan 13, 2018)
Tulsa suffered a blowout loss to Houston on Thursday that left coach Frank Haith disgusted. The Golden Hurricane have a chance to help their coach get that taste out of his mouth Saturday night, when No. 5 Wichita State visits for an American Athletic Conference tilt at Reynolds Center in Tulsa, Okla.
The Shockers (14-2, 4-0 AAC) have won six in a row and own the nation's longest road winning streak at 10.
Tulsa (10-7, 3-2 AAC) has dropped two straight, including the 104-71 drubbing they suffered at Houston.
"It's as tough a loss as I've been around in my whole career," Haith said on postgame radio, according to the Tulsa World. "I've never been part of a team that gave up 100 points. Our defense was absolutely pathetic, just very bad. I'm very disappointed."
The Golden Hurricane gave up 18 3-pointers, the most ever in an American Athletic Conference game, and looked deflated down the stretch.
"We didn't have any kind of fight or resolve with our team, and as a coaching staff we've got to figure this thing out," Haith added. "We've got to get better."
Wichita State arrives playing some of its best basketball of the season. The Shockers ripped through South Florida and East Carolina, beating the two teams near the bottom of the AAC standings by an average of 31.5 points.
Wichita State had 38 field goals off of 32 assists in Thursday's 95-60 rout of East Carolina.
The Shockers shot 70 percent from the floor and scored 50 points in the paint. Rauno Nurger had 14 points, and standout point guard Landry Shamet finished with 11 points and 11 assists for his first double-double of the season.
The 32 assists were the most ever in coach Gregg Marshall's tenure.
"That's a big-time number," Marshall said after the game. "It means we're very, very unselfish. When you can have 32 assists and 11 turnovers . . . that's pretty special."
The return of versatile junior forward Markis McDuffie from a foot injury has fueled the Shockers' surge. McDuffie, the team's leading scorer and rebounder last season, missed the first 11 games, but is rounding into form and contributing off the bench.
McDuffie had 12 points in 20 minutes against East Carolina, his third straight game with double figures in points. Marshall said there is no minutes restrictions on McDuffie at this point.
"It's just a matter of how well he plays," Marshall said. "He's such a dynamic talent with the ability to shoot the ball, drive the ball, rebound it ... And to be able to bring him off the bench and give us 20 very fresh and vibrant minutes is very, very good."
Senior forward Junior Etou leads the Golden Hurricane in scoring and rebounding, averaging 16.2 points and 6.9 boards per game. Etou struggled against Houston, though, going 0 of 6 from the floor and finishing with just two points.
With Etou experiencing an off night, forward Martins Igbanu stepped up and scored a career-high 27 points against Houston.
Tulsa and Wichita State, who were rivals in the Missouri Valley Conference, have met in each of the past seven seasons. The Shockers won six of those games, including 80-53 at home last season.

domain: sports


text:
Happy Friday! Ready for the weekend? Do you have fun plans? If you consider getting a haircut and watching the Grammys fun, then my weekend will be a blast!
When choosing this week's fun font, I was reminded that Valentine's Day is less than a week away and that there are lots of Valentine's projects still to be done. I like this font because it's got a vintage feel to it but could be used for a wide variety of projects besides just Valentine's Day. I've seen people use this font (or one similar to it) for layouts of trips to the circus, birthday invitations, vintage photos, baby announcements and more. It's a surprisingly versatile font.
You can get the font here.
Have a great weekend and happy scrapping!
Labels: Fun Font Friday

domain: design


text:
Gov. Gavin Newsom on Monday lamented the lack of a Rose Bowl game in Pasadena come Jan. 1, but insisted the surging coronavirus has left no wiggle room for public health leaders to allow an exemption to players’ guests to sit in the stands.
“Look, when you’re in Southern California, you’re at 0% ICU capacity, we can’t make exceptions,” Newsom said Monday during his afternoon briefing. “We have to be stringent in terms of our rules and our regulations. We have to do everything in our power to mitigate spread and to mitigate mixing. What they asked for was contrary to that determination and to our medium- and long-term goals.”
Those goals are to stop a virus that has laid siege all year, but in particular just as the holidays and the bowl game season coincide.
Last week was the deadliest yet in L.A. County, where on one day COVID-19 was responsible for 138 deaths.
The pandemic has shuttered fan attendance at sporting events in California since March. UCLA has played its home games at the 95,000-seat Rose Bowl since its shortened season started in November, including its regular-season finale on Saturday night. But that was without anyone in the stands.
Last glimmer of hope
Despite state and county prohibitions on fan attendance at professional sports, the Rose Bowl — the “Granddaddy of Them All” —- still had a glimmer of hope going into last week after weeks of appeals by Tournament of Roses officials to allow player guests to attend.
But with coronavirus cases and deaths mounting steeply, as well as hospital beds filling up, the Tournament of Roses received word late last week that the state of California would not make a special exception for player guests at the game.
The game itself, now on its way to Texas, is part of the College Football Playoff system, which the Rose Bowl has taken part in since 2014. The game that was supposed to be in Pasadena is between Alabama, first in the final College Football Playoff rankings released Sunday, and fourth-ranked Notre Dame.
Alabama-Notre Dame featured
The Alabama-Notre Dame semifinal was placed in Arlington, Texas, because 16,000 fans will be allowed to attend the game and 3,000 at the other semifinal, the Sugar Bowl in New Orleans, playoff Selection Committee Chairman Gary Barta told ESPN.
Early reports had dubbed the Texas game as the Rose Bowl presented by Capital One. But on Monday, it was unclear whether the Rose Bowl name will even be used. The name Rose Bowl is co-owned by the Pasadena Tournament of Roses and city of Pasadena.
On Tuesday, the Pasadena City Council will meet in a special closed session to decide on whether to allow the name to be used outside of the Pasadena venue. Officials said Monday that contractual issues — including the name — were still being hashed out by the Tournament of Roses, the city of Pasadena and the College Football Playoff organization.
If the Rose Bowl name is not used, it would be the first time in more than 100 years no Rose Bowl game was played after a college football season.
The first Rose Bowl was played on Jan. 1, 1902. Not until 1942 was a Rose Bowl game played outside of the city: Oregon State and Duke played in Durham, North Carolina — the only time the game has not been played in Pasadena. The attacks on Pearl Harbor had just occurred on Dec. 7, 1941, and the West Coast was not safe for such a game.
Massive economic losses
The Rose Bowl — and the Rose Parade (which is not traveling to Texas, but was canceled) — typically are massive economic engines for the city and the region.
In 2020, it drew $4.4 million in net income event revenue for the Rose Bowl stadium itself, and that’s not counting the huge impact on venues throughout Southern California as tens of thousands of fans from competing teams flood the region from out of state.
Locally, too, restaurants, hotels, ride-hailing companies and retailers all depend on both the bowl game and the parade for their bottom lines.
Business and city leaders were mindful that the city — like so many across the region and the country — is already hurting from months of shutdowns and reduced business. There were no illusions that this year’s game would have been a boon for the city. Still, though, they said the loss of the game punctuated a tragic year of losses.
Paul Little, president and CEO of the Pasadena Chamber of Commerce, said Pasadena businesses are in the unique position of having the Christmas shopping season and the Rose Parade and Bowl to bank on at year end.
“That anticipation that you’re going to have two opportunities to really make a lot of money within the space of essentially a month, or a month-and-a-half … it’s a huge influx for retailers, restaurants, tour companies, they are not going to see the income. Whether they can sustain the business without that income remains to be seen.”
City Councilman Tyron Hampton, who represent’s the city’s District 1, voiced disappointment in the state’s red line.
“We can’t accommodate 4,000 people in a stadium that seats 95,000 people?” he asked, rhetorically. “There’s no frustration here. This is government overreach. Businesses rely on this game.”
Newsom, who is the target of a recall campaign, said he was mindful of the critique — similar to the pushback he has received from restaurant owners, religious leaders and others in the COVID era.
“Know that none of this is what we want to do,” he said, stressing California’s pride in the Rose Bowl game. “It’s what we have to do to mitigate the spread.”
City News Service and Sports Editor Fred Robledo contributed to this story.


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Ala Vaikuntapuram lo Coming for these season with great stuff. Stylish Star Allu Arjun is gearing up for his upcoming action drama, get Sankranthi festival. Ala Vaikunthapuramulo. Bunny who is known for his vigilante roles in movies like Duvvada Jagannadham, Race Gurram, Sarrainodu, and many others now coming with Ala vaikuntapuram lo, it has been one of the most loved actors in the South Indian Film industry for known lesser facts.
Ala Vaikuntapuramlo Musical Concern Music Launch, Having evolved with his on-screen performances and winning the hearts of millions through his work, screen presence. Allu Arjun is certainly making his upcoming film Ala Vaikunthapuramulo look promising and look great in all aspects. Now according to the latest update, it will surely love the makers of Ala Vaikunthapuramulo are coming up with Diwali treat.
Ala Vaikuntapuramlo Musical Concern Audio Launch 2020
Ala Vaikunthapuramulo’s s audio launch musical concern will be released on the occasion of Diwali. Ala Vaikunthapuramulo is gearing up for its release on January 12th and it is one of the most awaited releases of the year. The film has Allu Arjun, Pooja Hegde, Nivetha Pethuraj, Navdeep, Sushant, Tabu, Jayaram and others in key roles. Promotions are in full swing for the family entertainer, which is being directed by Trivikram. The musical concert is expected to boost the buzz around the film further.
Musical Night audiences over having to spend high-level budget films Ala Vaikunthapuramulo’s first single ‘Samajavaragamana’ has become a massive success for known reasons, with over 40 million views on YouTube sensational on the industry. The first single has raised expectations with mass stuff.
Thaman is on the board to compose the music of this upcoming film Ala Vaikunthapuramulo Movie. The audio album of Allu Arjun’s Ala Vaikunthapuramulo is a smashing success and the makers of the film are organizing a musical night on January 6th to enthrall music lovers. The producers of Ala Vaikunthapurramuloo have confirmed that they will be holding a musical concert, in which Thaman will be playing live music.
check out Awesome content Sankranti films are coming forward to check online. Allu Arjun Latest movie ala vaikuntapuram lo musical concert. Telangana Increased ticket rates and Christmas films multiple charged more than usual rates. Trivikram ala vaikuntapuram lo and Mahesh babu’s Sarileru nikevvaru movie launching on this Sankranti festival. Some distributors come to know all basic things.
Both state governments to let them increase the rates during the release of the biggies for sure. The e-release event is scheduled to take place on 6th January at Yousfguda Police lines. Check out Guests list, ala Vaikunthapurramuloo initially planned to get a big star as the guest for their movie’s pre-release event plans too but they have now decided to go with the event without any guest check online.
The audio album of Ala Vaikunthapurramuloo which was scored by Thaman is a huge hit. We are entering 2020 with a blockbuster album and we would like to enthrall the audience by holding a musical concert on January 6th at Yousufguda police grounds. Ala Vaikunthapurramulo is gearing up for its release on January 12 and promotions are in full swing for the family entertainer. Check Out More News, Information Here.


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Description: Schematic showing proposed changes related to the IH 635 managed lanes project, including expansions, additions, and other construction on the highway. This is one segment of a larger improvement project affecting IH 35E between IH 635 and US 380. Scale 1:2,400 (horizontal), 1:240 (vertical).
Date: January 11, 2013
Creator: Texas. Department of Transportation.
Item Type: Refine your search to only Map
Partner: UNT Libraries Government Documents Department

domain: geography


text:
This training aid is paw-sitively perfect if your pup is obsessed with barking, stealing food, jumping or chasing. Once your canine companion ceases the unwanted behavior, be sure to reward him with his favorite treat, he certainly deserves it!
The rating of this product is 0 out of 5
A variety of animals use a hissing noise to drive away predators and The Company of Animals Pet Corrector Dog Training Aid releases a similar sound to help correct your dog’s bad habits. The sound released from The Pet Corrector is designed by training and behavior experts to distract your dog from his bad behavior.
Interrupts bad behavior and is an essential combination tool with reward-based training methods.
Emits a harmless hissing sound that is similar to the hiss of a snake or a cat to distract your dog.
With 200 uses per can, it is a great training aid to stop barking, jumping up, stealing food and chasing.
Comes with a training guide that informs pet parents of proper training and use.
Created by Dr. Roger Mugford and is recommended and used by behaviorists and trainers around the world.
Advice for Use
The 50-ml contains 50 uses per can and the 200-ml contains 150 uses per can. Read training guide before use. Press bottle top to make loud hissing noise to distract your dog from unwanted behavior. Reward dog immediately after negative behavior has ceased. It is important that the Pet Corrector is used responsibly and that desirable behaviors are rewarded.

domain: pet


text:
Combining his experience as the Florida A&M men’s tennis coach with his teaching methods as a pharmacy professor have enabled Dr. Carl Goodman to motivate his players and students to strive for excellence.
During his time attending Jacksonville University, Goodman played on the tennis team and learned the fundamentals of the game. Goodman has been coaching the FAMU men’s tennis team for more than 11 years.
Sophomore Takura Happy said Goodman’s support has been an essential part of his growth as a young man and a tennis player during his time at FAMU.
“He’s been more like a father figure to me since I left Zimbabwe,” Happy said. “He’s taught me about taking responsibility when it comes to class work, being disciplined on the court and leading the team by example. I’ve learned how to lead, he showed me that in order to be a good leader I have to be able to follow those with wisdom first.”
Goodman has been a professor at the College of Pharmacy and Pharmaceutical Science for 14 years, and currently instructs graduate level courses. Teaching classes with eight graduate students and two research associate students working under him, Goodman encourages his players to balance their time.
“It’s all about stressing time management to my players,” he said. “The things I implement with tennis help me in the graduate program. With my eight students, we talk about team building, sharing and helping each other out for the goo of our lab. These are the things that cross over in all aspects of life.”
Senior Michael Moore said Goodman has the ability to keep the FAMU tennis team loose and mentally focused before competition.
“A lot of people might perceive coach as a serious person, but it’s the complete opposite,” Moore said. “With us he jokes around a lot especially before matches so we definitely feel comfortable when we’re with him.”
Ebenezer Oriaku, a professor and colleague of Goodman’s in the College of Pharmacy, said Goodman is passionate about his professional and viewed as a very trustworthy individual.
“I’ve known Dr. Goodman from my days as a student at FAMU,” Oriaku said. “He’s a very caring individual that has done a lot for the school and for athletics also. I’ve worked for him at least 14 years and you can take his word for what he says. You can trust him and have confidence that he will get whatever he tells you done.”
Goodman said longevity has been an essential factor in the gaining his players trust, which has been a direct result of his team’s success during the last 20 years.
“We’ve never finished anything less than second in 20 years with the conference,” he said. “The tennis team was nationally ranked three times since 2000 and won at least six HBC championships.”
Junior Stephan Black said Goodman is always willing to help his students whenever they need assistance.
“He always has a smile on his face and he’s a really laid back personality,” Black said. “He’s very approachable; when Dr. Goodman isn’t traveling he always finds time to help out all of his students.”


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Details about Paraoxonases in Inflammation, Infection, and Toxicology:
Biomarkers are used in many aspects of health surveillance to identify disease pr- ence, track disease progression, monitor drug delivery or metabolism, or monitor chemical exposure. There is a recognized need to expand and improve biomarker identi?cation and quanti?cation. Exposures to the xenobiotic organophosphates (OPs) range from low-level, chronic exposure during pesticide application (e. g., on farms, in residences, or in the workplace) to high-dose, acute exposures incl- ing release of nerve agents or toxic industrial OPs. OPs can have both rapid and chronic toxicity, due to their action on speci?c esterases and lipases, most notably acetylcholinesterase (AChE) and neuropathic target esterase (NTE). In each of the above examples, a rapid and accurate assessment of the OP to which the person was exposed, degree of exposure, and time period of exposure will help direct therapy to the victim and assess the level of threat to others. Traditionally, metabolites for speci?c OPs can be measured in the urine after an exposure, such as 3,5,6-trichloro- 2-pyridinol for chlorpyrifos (CPS). However, there are several problems with this method.Usually, the metabolite is excreted for only a short period of several days after a signi?cant exposure. In addition, due to the widespread use of CPS and en- ronmental persistence of its breakdown products, the metabolites appear at a high background level in the general population (Hill et al. 1995). Their appearance does not indicate whether the individual was exposed to the harmful parent compound, or the harmless breakdown product.
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Rent Paraoxonases in Inflammation, Infection, and Toxicology 1st edition today, or search our site for other textbooks by Srinivasa T. Reddy. Every textbook comes with a 21-day "Any Reason" guarantee. Published by Humana Press.
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domain: chemistry


text:
Holistic medication for remedy of arthritis is changing into an increasing number of standard. Traditional medicine is taken into account various when it is used outdoors its dwelling area; or when it is used along with or instead of identified useful therapy; or when it can be moderately expected that the affected person or practitioner is aware of or should know that it’s going to not work – similar to understanding that the follow is predicated on superstition.
A correctly balanced holistic well being regimen, which takes into consideration all features of human health and contains noninvasive and nonpharmaceutical healing strategies, can usually completely eradicate even acute well being situations safely.
Crossref PubMed Scopus (3388) Google Scholar See all References of the extent of alternative or unconventional therapies, outlined as therapies neither taught extensively in US medical schools nor usually available in US hospitals,â€ was revealed in 1993.
As GP and journalist, James Lefanu famous in his book, The Rise and Fall of Modern Medication, written in the 50s, a series of medical breakthroughs proved beyond a doubt that previous makes an attempt at healing have been nothing greater than mere quackery.
Physician Of Holistic Medication (HMD) Program
Cats Claw is a medicinal Herb from the Forest of Peru. Additionally they bear in mind the person’s look, demeanor and body language Homeopaths use the vital force assessment to information dose (potency) selection and treatment pace and to judge the doubtless clinical course and prognosisâ€ (Bell et al., 2004, p.124).
It’s necessary to take into account that TCM is a reflection of a selected tradition, like Ayurvedic medication which was developed in India A few of the parts that are essential to TCM embrace: private observations of the physician, a subjective foundation for analysis, healing as a method to balance the body’s processes, measuring the outcomes of treatment qualitatively (versus quantitatively) and gearing the treatment to the person and not the condition (Shea, 2006).anonymous,uncategorized,misc,general,other
Types Of Complementary And Alternative Medication
The purpose of the holistic practitioner is to assist the affected person to seek out ways to change into healthier and to boost and strengthen the physique’s immune system.
holistic medicine wiki, holistic medicine doctors nyc, holistic medicine schools near me, holistic medicine schools in florida, holistic medicine schools nyc
It’s possible you’ll hear numerous difference terms when taking a look at treatments on your conditions. It emphasizes issues of the a number of interacting techniques that regulate the physique’s internal world.â€ Scientific integrative medication asks researchers and clinicians to think about more than one system at a time, as assessed by measuring levels of multiple chemical effector at a time.
For instance, when a person affected by migraine headaches pays a go to to a holistic physician, as an alternative of walking out solely with medicines , the doctor will possible check out all the potential factors that could be causing the particular person’s headaches , similar to different health issues, eating regimen and sleep habits, stress and private issues, and most well-liked religious practices.
How Hashish Matches Into Holistic Medicine
Scripps Heart for Integrative Medication gives one of the best of typical and complementary drugs. The people healers appealed to the poorer factions of society, in that they used pure therapies that were extra affordable and easier to come back by. Folks healers were typically extremely respected in these underprivileged sections of society.
These complementary therapies and medicines are used to scale back or ideally remove the necessity for continual drug remedy, allowing aid from the illness with out the troubling unintended effects so often seen with conventional treatments.
holistic medicine schools in california, holistic medicine definition, holistic medicine doctor chicago
The holistic method in medication is principally achieved through the complementary or different therapies and medicine. Integrative drugs has been defined as the observe of medicine that reaffirms the significance of the relationship between practitioner and patient, focuses on the entire particular person, is knowledgeable by proof, and makes use of all applicable therapeutic approaches, healthcare professionals and disciplines to attain optimum well being and therapeutic.â€ 2 x2Consortium of Tutorial Health Facilities for Integrative Drugs.

domain: medical


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With a superb victory over Leeds, we are determined to continue our great start to Super League 24 when Hull Kingston Rovers come bobbing along to the Halliwell Jones this Saturday 9 February, 3pm kick-off.
Hard work in defence that restricted the Rhinos to one try three minutes from the end of last Saturday’s match and adventurous off-loading that kept up the pressure on the attack won the day at a packed HJ and home fans will be hoping for more of the same this weekend.
But the Robins will certainly be up for this one too.
They stunned their city rivals FC in the season’s opener last weekend when one of their new signings, German international Jimmy Keinhorst, dived over in the corner to score the winning try just 10 seconds from the end of the match.
It was a game watched by a Craven Park record attendance of more than 12,000.
The Robins, coached by the legendary Tim Sheens, have made a host of new signings for the campaign. Goal-kicking half back Josh Drinkwater has been recruited from the Catalans Dragons and experienced forward Mitch Garbutt moved to Hull from Leeds along with Keinhorst.
Electing to continue his career on the breezy east coast rather than the near-tropical North Queensland is Cowboys star Kane Linnett who can play both in the threequarters and the forwards.
Weller Hauraki and Ryan Lannon have both been signed from Salford Red Devils.
Young Will Dagger who made several appearances at full back for Wire before moving to Hull last season may be at full-back while our former Academy winger Ryan Shaw is an integral part of the KR line-up these days.
Undoubtedly a danger man is prop Robbie Mulhearn who earned an England cap against France last autumn and was then selected for the England Knights tour of Papua New Guinea.
Centre Ben Crooks joined the club from Leigh Centurions in the middle of last season and Craig Hall, having figured in the Rovers’ colours before, made the switch from Toronto. Forward Joel Tomkins also moved to the Robins from Wigan last term and has settled in so well that the players voted him to be captain this season.
Half back Danny Addy is back in action after missing the whole of last season but the visitors will be without hooker and former captain Shaun Lunt who is on the mend after serious illness along with forwards Nick Scruton and Lee Jewitt and full back Adam Quinlan who are all recovering from injuries.
Wire and Hull KR have been involved in many memorable matches over the years. Who can forget that fabulous Lee Briers drop goal in golden point time at Craven Park that took us into the Challenge Cup semi-final and ultimately the final at Wembley in 2009?
Two less happy Challenge Cup memories for us were the quarter-final defeat by 40-36 on Humberside in 2006 and the semi-final loss at Leeds 26-18 in 2015.
We won both of our encounters last season, 40-26 at home and 34-20 away. Jack Hughes scored two tries in the game at the HJ and Mike Cooper and Stefan Ratchford touched down in both games.
In a points-fest in January 1993 we defeated Rovers 47-26, Mark Forster and Kevin Ellis each scoring two tries.
In January 1989 we rattled up 60 points against Rovers at home, Mark Roberts scoring two of our 11 tries.


A criterion for automatic image deconvolution with L0-norm regularization
Automatic penalty adjustment in sparse deconvolution with penalized least squares is required for improved reliability and broader applicability. In sparse deconvolution with an L0-norm penalty, the latent signal is by nature discontinuous, and the magnitudes of the residuals and sparsity regularization terms are of different order of magnitude. This makes approaches such as generalized cross validation or L-curve unsuitable in practice. The criterion proposed in this paper is based on the representation of the sum of the normalized residuals and regularization terms (SNT) as a function of the penalty parameter. We observed that the minimum of the SNT corresponds to the optimal value of the penalty parameter. This approach was tested in the context of super-resolution fluorescence microscopy imaging. Both simulated and real live-cell images characterized by different complexities and emitter densities were analyzed to assess the performance of the developed optimization strategy and to demonstrate its usefulness over manual tuning.
|deconvolution, image, optimization, regularization parameter, sparsity|
|Journal of Chemometrics|
|Organisation||Department of Biostatistics|
Ahmad, M. (Mohamad), Hugelier, S. (Siewert), Vitale, R. (Raffaele), Eilers, P.H.C, & Ruckebusch, C. (2020). A criterion for automatic image deconvolution with L0-norm regularization. Journal of Chemometrics. doi:10.1002/cem.3227


Nature gas hot dip galvanizing furnace for zinc kettle
Summary: environmental protection and energy saving, high degree of automation, high efficiency, safe and reliable.
- The furnace body assembled by ceramic fiber module.
- Adopt high speed pulse diagonal heating, so that the zinc pot heated evenly;
- High combustion efficiency, emission targets reach to achieve national environmental standards;
- Fully automatic temperature control, high precision temperature control;
- Can keep the record of temperature, pressure and alarm for above one month.
- The temperature can be set according to the zinc solution and furnace, Dual temperature control can be realized;
- High safety factor, with a variety of fault alarm records;
- A small number of Nozzles, low maintenance costs.
Hot Dip Galvanizing Production Line Process:
We offer industry-leading consultancy, engineering, project management, constructin management, regulatory compliance, and environmental expertise to our clients in the galvanizing industry who need to set up the plant on turnkey basis.
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Hebei Annuo Automation Technology Co., Ltd.


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Lisa Callif and Dean Cheley Named to Variety Dealmakers Impact Report 2016
Partners Lisa Callif and Dean Cheley were recognized by Variety as part of the 2016 Dealmakers Impact Report. Lisa was highlighted for her work securing funding for documentaries that bring awareness to social issues, while Dean was spotlighted for his work in the emerging online markets.
Lisa works with producers and financiers who are emotionally connected to certain socially conscious documentaries. Such projects often obtain funding in relatively small increments from multiple investors, foundations and distributors. “Typically, the funding comes in waves over a long period of time,” Lisa said. “A filmmaker can start making a film with just a camera.”
Variety also highlighted deals Dean has made in the online space, working with platforms such as Amazon Studios, Netflix, YouTube Red, and Vimeo. He has enabled numerous producers to create a roadmap for financing and distribution, leading to deals that allow their works to be seen.
Each year, Variety profiles the people behind the most important entertainment industry deals of the past 12 months, featuring those who have had an undeniable impact on the entertainment world.

domain: artistic


|The Kerala Public Service Commission (Kerala PSC) Recruitment 2021 Notification – Eligibility, Salary, Admit Card, Exam Date and full Notification|
The Kerala Public Service Commission (Kerala PSC) has invited eligible candidates to apply for the various posts. Other Important details about this job post of like Education Qualification Details, Required Age Limit, Job Location, Mode Of selection, Fee Details, Exam Date and Apply Process are given below.
|Recruitment Organization||The Kerala Public Service Commission (Kerala PSC)|
|Post Name||Assistant Professor (in Various subjects)|
|No. of Post||21|
|Qualification||A Post graduate Degree in Ayurveda in the concerned subject from any of the Universities in Kerala|
|Selection Mode||writing the examination|
Post Name and Nos.
|Assistant Professor (in Various subjects)||21|
|Assistant Professor (in Various subjects)||A Post graduate Degree in Ayurveda in the concerned subject from any of the|
Universities in Kerala or from any other University recognized by any of
the Universities in Kerala
|Assistant Professor (in Various subjects)||As per UGC norms|
Fee Detail-Refer official notification
|Minimum Age||20 Years|
|Maximum Age||46 Years|
|Relaxation Applied Please Refer Official Notification|
|Application Begin Date||06/05/2021|
|Last Date for Apply||02/06/2021|
|Official Website||Click Here|
|Pdf Notification||Click Here|
|More Jobs||Click Here|
For Regular Notification Join Now
Steps to Apply For Online Mode :-
1) Log on to the official website www.keralapsc.gov.in/
2) Start 06/05/2021 and will be closed on 02/06/2021
3) Click on Career Page or Related Notification on Page.
4) Candidates can apply through online
5) Candidates should ensure that they fulfill the eligibility criteria as per requirements
6) Pay the application fee, if needed.
7) Click on the submit button for submission of the application.
Very Important Instructions
Before Applying, Candidate are advice to go through the instructions given in the notice of examination of very carefully.


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It saddens us to have to report that as a result of receiving a dose of either the Pfizer / BioNTech MRNA vaccine or the Oxford / Astrazeneca Viral Vector (still mRNA technology), a total of twenty women have now had to suffer the grief of having a miscarriage and losing their unborn child.
Adverse reactions to both jabs reported to the MHRA Yellow Card scheme up to the 21st February shows that the number has almost doubled in just seven days when compared with the previous weeks data, which included adverse reactions to both jabs. As of the 14th of February 2021, a total of eleven women had lost their baby with three of those being due to the Oxford vaccine and eight of those being due to the Pfizer vaccine.
The MHRA Yellow Card data now shows that the Oxford jab has caused four women to sadly lose their unborn child, an increase of one on the previous weeks data.
However the Pfizer jab has now caused, as of the 21st of February, a total of sixteen women to sadly lose their unborn child, a figure which has doubled from the eight seen in the previous week up to the 14th of February.
As of the 14th of February there had been 8.3 million doses of the Pfizer vaccine administered, with the Oxford jab lagging behind by 1.4 million at just 6.9 million doses administered. But fast forward to the 21st of February, a further 1.1 million doses of the Pfizer jab were administered, and a further 1.5 million doses of the Oxford jab.
However the number of adverse reactions to the Oxford jab is nearly double than what has been reported for the Pfizer jab, with 157,637 adverse reactions to the Oxford Jab being reported, compared with 85,179 adverse reactions to the Pfizer jab being reported as of the 21st of February 2021.
Whilst the Oxford vaccine outnumbers the Pfizer jab significantly in terms of adverse reactions, the data now clearly shows the Pfizer jab to be much more dangerous when it comes to being administered to pregnant women.
But why is this happening?
Well when the Pfizer jab was first approved for emergency use only in the United Kingdom, meaning the manufacturer is not liable for any harm or injury caused by their product, the Government’s advice was as follows –
There are no or limited amount of data from the use of COVID-19 mRNA Vaccine BNT162b2.
Animal reproductive toxicity studies have not been completed. COVID-19 mRNA Vaccine
BNT162b2 is not recommended during pregnancy‘
‘For women of childbearing age, pregnancy should be excluded before vaccination. In addition, women
of childbearing age should be advised to avoid pregnancy for at least 2 months after their second dose.
This was taken from a document released by the Government titled ‘REG 174 INFORMATION FOR UK HEALTHCARE PROFESSIONALS’, of which we reported to you back in December 2020.
4.6 Fertility, pregnancy and lactation
There is limited experience with use of the COVID-19 mRNA Vaccine BNT162b2 in pregnant women.
Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy,
embryo/foetal development, parturition or post-natal development. Administration of
the COVID-19 mRNA Vaccine BNT162b2 in pregnancy should only be considered when the potential
benefits outweigh any potential risks for the mother and foetus.
How many more women need to suffer a miscarriage to stop this madness?
So now we know why pregnant women have started to be inoculated with the experimental jabs, because the Government quietly changed its own advice based on zero evidence to support it. Even going as far as to remove the recommendation that women of child bearing age being told to avoid pregnancy for at least two months after their second dose.
Statistically these women stood no chance of suffering from serious illness due to the alleged SARS-CoV-2 virus and the alleged resulting disease Covid-19, (total recovery rate = 99.97%, fatalities = 0.03% with an average age of 84 – with underlying serious health problems prior to infection, which they may have died of anyway). You work out the overall risk for yourself.
Now sadly those in the 0.03% group who are pregnant may have to suffer the misery of losing their unborn baby. Furthermore, with a big question mark over their future fertility through this injection, they may have lost the only child they could ever have.
BE SURE THAT YOUR CHOICE TO GET VACCINATED WITH AN UNTESTED EXPERIMENTAL INOCULATION IS AN INFORMED CHOICE.
And The Final Word Goes To “The Old Man In A Chair”
Credits: Original article published on The Daily Expose website. Checks for accuracy, minor edits and formatting changes by BGB.
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The latest Maine Poll shows Republican Paul LePage with a slight lead in the race for governor and Democratic incumbents Rep. Chellie Pingree and Rep. Mike Michaud with significant leads – although not quite as large as last month for Pingree – in their re-election bids to the U.S. House of Representatives.
Including voters who may be undecided but are leaning toward a particular gubernatorial candidate, a statewide telephone poll of 605 likely voters sampled Sunday and Monday showed 34 percent prefer LePage. Democrat Elizabeth “Libby” Mitchell received support from 29 percent of respondents with independents Eliot Cutler (13), Shawn Moody (6) and Kevin Scott (1). Eighteen percent remain undecided.
The sampling error is plus or minus 4 percent at the 95 percent confidence level.
A similar poll two weeks earlier that didn’t tabulate voters leaning toward a particular candidate showed Mitchell (30) and LePage (29) in a statistical dead heat with Cutler at 11 percent. The undecided contingent was 26 percent.
In the Congressional races, Republican Dean Scontras of Eliot made up some ground on Pingree in Maine’s 1st District, rising above 30 percent for the first time to 33. Meanwhile, support for Pingree fell below 50 percent, to 48, with one in five likely voters remaining undecided.
In the 2nd District, Michaud held a 43-30 advantage over Republican challenger Jason Levesque, a gap largely unchanged from a poll two weeks earlier.
Voters also indicated support for Question 1, which would allow a group of investors to build a casino in Oxford County. Fifty three percent indicated they would vote for the casino, 43 percent against and four are undecided.
Another poll released Wednesday, by Rasmussen Reports, shows LePage leading Mitchell, 35-32, with Cutler jumping up to 21 percent. The automated poll did not ask respondents about Moody or Scott and reported only six percent of voters undecided.


A Santa Paula man has pled guilty to first-degree murder for the 2014 killing of his pregnant girlfriend.
Antonio Magana is accused of stabbing his then girlfriend Ashley Morgan in Obregon Park, according to the Ventura County District Attorney’s Office. Magana admitted to using a knife and a baseball bat during the attack.
The District Attorney’s Office said Magana wanted Moran to end her pregancy, but she refuced.
On March 14, 2014, Magana struck Moran in the park and stabbed her in the neck. Her body was found the next morning, the District Attorney’s Office said.
Magana’s sentencing hearing is set for Dec. 5, 2019. It is expected that Magana will be sentenced to a term of 27 years to life in prison.


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inability of a person, animal or plant to reproduce by natural means that is no intervention of contraceptive techniques
Infertile means not able to have children or other offspring. Humans can be infertile, but animals and plants can too. When a human couple is infertile, they sometimes have fertility treatment to have children. This can be insemination or IVF. They also sometimes adopt a child.
- SexInfo's Assisted Reproductive Technology Archived 2007-04-30 at the Wayback Machine This article discusses Artificial Insemination, In Vitro Fertilization, and other options for couples who are having trouble conceiving.


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A social worker can help improve the quality of life for your loved ones.
Some social and interpersonal difficulties cause people to face problems that can become very complicated.
The social worker protects children, adults and families in need.
It is for this reason that at The Lakes Home Care, our team of social workers is ready to help our patients, in the treatment of each of these problems, so that they can communicate and relate better with other people.
So, if you are looking for help, call us today 305 817 39 12 and receive free guidance

domain: sociology


Section 4: Organization of Manual and Guide
Both the Manual and the Guide are organized by chapters reflecting the steps that occur during project development. Each chapter contains a brief introduction and includes links to many different manuals and other information supporting that chapter. Each chapter is intended to be independent and has a format that is reflective of the materials that are covered.
The Chapters in the Manual and Guide are organized according to the sequential steps in project development and are provided in order:
- Anchor: #ONMAIBVG
- Introduction – explanation of how to best utilize the Manual and Guide as resources in project development; Anchor: #DPAWVVGJ
- Project Initiation – project planning, programming, Advanced Funding Agreements, State Letter of Authority and contracting with TxDOT; Anchor: #KBFDRJTF
- Non-construction Projects – transportation-related projects or programs that do not involve the building of infrastructure; Anchor: #RYPITFNO
- Preliminary Engineering and Design – procurement of professional services, project design through 30 percent complete; Anchor: #GFQVUPVI
- Environmental Compliance – environmental policies, practices and compliance; Anchor: #UFWQYUJJ
- Right of Way and Utilities – real property acquisition, utility relocation and utility service to projects; Anchor: #KXYKJPLV
- Plans, Specifications & Estimate (PS&E) Development – development of engineering specifications and plans, and bid document preparation; Anchor: #WHAVVCHV
- Letting and Award – advertising, bidding and awarding a construction contract; Anchor: #OCHWCRBI
- Construction – building phase of local government projects; and Anchor: #WNTOOPPL
- Project Close-Out and Maintenance – financial close-out and document retention, audit and maintenance.