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Welcome to the latest edition of E Parkinson Post!
We all know how important it is to maintain good relationships with our health care professionals, such as family physicians, specialists and physiotherapists. Whether it’s asking the right questions and getting reassuring answers or knowing how to get an appointment in a timely manner, it helps to know how to navigate the health care system.
This issue is devoted to improving communication with health care professionals. We asked both people with Parkinson’s and health care professionals for their best advice. Larry Peabody, a person with Parkinson’s and someone who has worked in health care, shares his perspective. You’ll also find tips from a neurologist, clinical nurse specialist and physiotherapist, all of whom have lots of experience with Parkinson’s disease.
We’ve also provided articles on other areas of interest and profile Dr. Ami Gupta, a young physician-scientist. Please visit us at www.parkinson.ca for more information.
Comments, questions, and story ideas are always welcome. You can send them to email@example.com.
In September 2002, my life changed forever. I was 53 years old and enjoying one of those peak experience times in my life. I had just celebrated my daughter’s wedding and returned to my position as senior consultant, Organization Development at the Calgary Health Region, having been seconded to Health Canada as director of the International Health Bureau for the 2002 Kananaskis G8 Summit.
A week later, I plummeted into a dark valley when I heard the neurologist say, “Parkinson’s syndrome,” after hearing the symptoms I had described only moments earlier. That was the day I began a new journey, as a patient, in the same healthcare system I was employed in.
I soon discovered that being a patient was not that different from being an employee, in that there were times when I felt frustrated and powerless in my attempts to make sense of this large, complex and often confusing system of “disconnects”.
During a brief stay in hospital a few months after my diagnosis, I was seen by the on-call neurologist. Since then, he has provided me with excellent care.
Although the healthcare system can be frustrating to navigate, it is becoming more open to innovation, as old ways of thinking and practising give way to new opportunities to improve how we can work together.
In October 2008, I attended one of the Parkinson’s Society of Southern Alberta’s Health Partnership Dialogue events: http://www.parkinsons-society.org/Events2008_HealthCare.aspx. Over 100 people with Parkinson’s disease, family members, friends, and caregivers shared their stories and, with a strengthened collective voice, identified common service gaps and made recommendations for improvements.
They raised issues and offered tips that resonate with my personal experience:
Access to information and psychosocial support at the time of diagnosis Learning that you have Parkinson’s disease is a frightening and devastating experience that often leaves you in a state of shock and disbelief. Empower yourself by gleaning information from your family physician, local Parkinson Society or Public Health services, the library and web sites. Being informed gave me a sense of control at a time when everything seemed to be out of control.
Taking charge of the medical intervention plan
Choose to not let fear, frustration or denial keep you from getting the best services available to you. Denial initially cushions bad news but, if maintained, it prevents us from using the help we need to manage our Parkinson’s effectively. Be your own advocate or bring a trusted person along to appointments to be an additional listener and to help address issues on your behalf. You don’t have to go it alone, but do go as an informed person.
Clarification of the follow-up plan
Ask questions: What do I need to do? Who do I need to talk with? Where can I go for information and support? When and how often will I see you or another doctor? Write down the questions that are pertinent to you. Remember, there are no wrong questions, when speaking with health care providers. It’s your body and your life!
Getting the real help that YOU need
Don’t be afraid to ask for the specific supports you need. Being diagnosed with Parkinson’s is a life crisis that threatens your emotional stability and may bring to the surface issues that impede your ability to cope with the ongoing challenges. Seek out professionals who can address your emotional, social and spiritual needs. Find out how to access services 24/7 in the event of a crisis, such as, medication reactions, sudden behavioral or cognitive changes that may create anxiety for you and your caregivers.
The time immediately following my diagnosis was one of the most stressful periods in my life. I felt powerless over this disease that threatened to take my life away, piece by piece. I needed hope for my future. I needed to trust my healthcare system and the people it employed. For me, my hope and trust emerges out of my personal faith and the assurance that my family and I will receive the right support and information at the right time, at the right place.
Over time, I have come to realize that my greatest source for hope and trust comes from within. It comes from knowing that I have a responsibility for the effective management of my treatment for me and my family. And that I have a responsibility to speak out, on behalf of those whose voice has been quieted or taken away by Parkinson’s disease leaving them powerless to communicate their needs or concerns about their healthcare experiences.
Dr. Ami Gupta is young, bright and totally dedicated to making the patient experience a positive one.
At a glance
• Current status: Dr. Ami Gupta is halfway through the first year of a two-year clinical movement disorders fellowship at the Morton and Gloria Shulman Movement Disorders Centre at Toronto Western Hospital.
• Fast Facts: He has a medical degree from the University of Heidelberg, Germany, and a PhD in neurosciences from Harvard University. He recently completed his neurology residency at Johns Hopkins University.
• Achievements: He was awarded the Novartis Pharmaceuticals Canada Clinical Movement Disorders Fellowship in November 2008 through Parkinson Society Canada’s National Research Program.
• Quick quote: “The difference between a physician-scientist and a family doctor is that the physician-scientist not only thinks about issues that affect patients but also follows that up with research.”
Dr. Ami Gupta’s love of mysteries and keen appreciation of “the beauty of the brain” make him ideally suited to studying and treating movement disorders.
Dr. Gupta, 38, is a physician at the Movement Disorders Centre in Toronto, where he is developing specialized expertise in diagnosing and treating movement disorders, under the supervision of Dr. Anthony Lang.
He is also a scientist with a background in basic science research conducted in the lab.
Now, he is adding clinical research to his portfolio, embarking on two research projects: one, looking at MRI-supported diagnosis in Multiple System Atrophy (MSA); the other, investigating cognition problems also in MSA, which is a disorder similar to Parkinson’s disease. It’s part of his bid to gain a deeper understanding of movement disorders and develop better ways to treat them.
In the few short months, since he began seeing patients at the Movement Disorders Centre, two days a week, Dr. Gupta has been surprised to learn that many of his Parkinson’s patients find their non-motor symptoms to be the most troublesome. “People tell me, ‘doctor, if you could help improve my sleep and my thinking that would be so much more potent than making me a little bit faster.’”
It’s an insight he may never have picked up had he continued working solely in the lab. His one-on-one relationship with patients has opened his eyes to new research possibilities.
“My perspective has become, what can I do to translate the knowledge I gain from research into something that can help Mr. or Mrs. Smith?”
When his clinical fellowship ends in June 2010, Dr. Gupta expects to carve out a career of continuing to provide excellent patient care. He’s just not sure yet whether he will combine his physician duties with clinical research or basic research.
Whatever his decision, it can only work to the benefit of his patients because, by then, he will have had the advantage of seeing what movement disorders look like in day-to-day life and he will have a vested interest in addressing the kinds of research questions that people with the lived experience of movement disorders want to have answered.
“Having trained in neurology and neuroscience, and worked at the interface of science and patient care, I will actually be able to do research based on what I have observed in the clinic.”
Internationally renowned neuroscientist highlights new developments in Parkinson’s
Dr. J. William Langston, founder, CEO and Scientific Director of the Parkinson’s Institute in Sunnyvale, California addressed a packed banquet hall in Calgary, Friday, January 9th at the 2008 Donald Calne Lecture, hosted by Parkinson Society Canada and Parkinson’s Society of Southern Alberta (PSSA), and sponsored by Solvay Pharma. Dr. Langston brought up to date an audience of over 120, including attendees of the Parkinson Research Alliance meeting, on developments in Parkinson’s.
Earlier in the day, Dr. Langston presented Grand Rounds at Foothills Hospital where he talked about the latest stem cell progress in Japan. Scientists are using skin samples to generate stem cells which could one day lead to the reversal of Parkinson’s.
Special thanks to John Petryshen and his wonderful staff and volunteers at PSSA for all their help in making the event run smoothly.
Developments in Parkinson’s
• PD is very likely a protein folding disease like ALS, Alzheimer’s and Huntington’s
Researchers now know that, in Parkinson’s, the protein, a-synuclein, becomes toxic and destroys the cells when it does not fold properly. “This represents a huge shift in the thinking about PD and makes the area of protein folding an important therapeutic target,” said Langston.
• PD may begin in the olfactory bulb
Dr. Langston noted that loss of smell may occur long before the onset of other symptoms, making the olfactory bulb, which governs the sense of smell, a prime target for investigation. “No matter how many people get Parkinson’s, it usually begins with the loss of the sense of smell but only 60 percent of people realize there is a problem.”
• Environmental factors play an important role in PD
Dr. Langston cited many studies showing a link between the use of pesticides and herbicides and Parkinson’s.
Over 50 published studies show an inverse relationship between PD and smoking, according to Dr. Langston. “If you smoked from the time you were a teenager, your risk of getting Parkinson’s is much less.” However, cigarette smoke has 4,000 chemical compounds, so finding the right one poses its own challenges, he cautioned.
Coffee drinking also seems to reduce the risk of Parkinson’s.
• Genetics loads the gun, but the environment pulls the trigger
Dr. Langston discussed the long-standing debate about genetics versus environment and reviewed the studies of twins, both identical and fraternal which showed that the environment plays a role. “While genetics loads the gun, the environment pulls the trigger,” he said.
New research-gathering techniques
Dr. Langston spoke about using the internet to gather research, citing 23andMe, the company that won Time Magazine’s #1 Invention of the Year award, as one example. 23andMe is embarking on a genome project where you “spit in a cup”, send it to a central location and six weeks later, receive a personalized genome that traces your genetics, where your ancestors came from and whether you will ever be an Olympic sprinter. It also can tell whether you are at risk for Type 2 diabetes and which diseases are high risk for you. This study has the ability to gather massive amounts of population information and could change the future of research.
New California Parkinson’s Registry
California recently passed into law new legislation which calls for all cases of PD to be reported in the State of California. According to Dr. Langston, both patients and doctors wanted this law.
Throughout the day, Dr. Langston made stops at radio, television and print media doing interviews with:
• Breakfast Television, CITY TV, 7:07 am. 6 min. with Dave and Kathy – Dr. Langston Interview • AM 660: Rogers 10 min. with Aaron Burnett
• The Medical Post
• CBC Radio – Wild Rose Country – 1:07 p.m. – 1:15 p.m. The fight against Parkinson’s disease with Host Donna McCelligott
• The Calgary Herald
DVD coming soon
The Donald Calne Lecture was recorded and will be available soon at www.parkinson.ca.
Ottawa school teacher, Shelby Hayter, has been awarded one of Parkinson Society Canada’s highest honours, the Morton Shulman Award, for her determination and creative spirit in piloting a unique educational program aimed at children in elementary schools and for teaching over 10,000 children what it means to live with Parkinson’s.
In the Pass the Baton program, Shelby, who has Young Onset Parkinson’s disease, shares the stage with a medical professional and a researcher from the University of Ottawa Parkinson’s Research Consortium.
“It is a perfect forum to teach our young audiences that we work as a team and together we can make a difference,” says Shelby.
Through the Pass the Baton and Pounding the Pavement programs, Shelby has raised thousands of dollars for Parkinson’s research. She says, “I feel fortunate to have the time, energy and enthusiasm to be an advocate for a disease which seems to have a quiet voice. Many people are not in a position to be advocates, due to personal situations; but for those who are in a position to help out, like myself, it is an amazing process to realize how one person’s efforts CAN make a difference.”
The Morton Shulman Award is given annually to an individual or organization who, through fearless advocacy and an ability to make change, makes life better for Canadians with Parkinson’s and their families.

domain: medical


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Submitted to: Virus Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/13/2009
Publication Date: 6/1/2009
Citation: Ajithdoss, D.K., Reddy, S.M., Suchodolski, P.F., Lee, L.F., Kung, H.J., Lupiani, B. 2009. In Vitro Characterization of the Meq Proteins of Marek's Disease Virus Vaccine Strain CV1988. Virus Research. 142(1-2):57-67. Interpretive Summary: Marek's disease (MD), a virus-induced cancer-like disease of chickens, is a major disease problem in commercial poultry. This disease is caused by a virus called Marek’s disease virus (MDV); the virus produces a protein called Meq thought to be involved in induction of MD. Earlier studies have shown that the Meq protein of a virulent strain of MDV is essential for causing the disease. The data in this manuscript provides the first evidence that Meq proteins from MDV vaccine strain named CVI988 are generally weak cancer inducers; the data explained the non-cancer causing properties of strain CVI988 of MDV in chickens. This information is essential to develop more effective vaccines against MD.
Technical Abstract: Gallid herpesvirus 2 (GaHV-2), commonly known as Marek’s disease virus serotype-1 (MDV-1), causes T cell lymphoma in chickens. Vaccines prepared from the CVI988/Rispens MDV-1 strain currently offers the best protection. Although, CVI988 is non-oncogenic, it codes for at least two forms of the MDV oncoprotein Meq, and these proteins (CVI-Meq and CVI-L Meq) have not previously been characterized. Here, we report that both CVI-Meq proteins, like the Meq protein of Md5 (a very virulent oncogenic strain) were capable of transforming Rat-2 and NIH3T3 cells. CVI-Meq proteins activated the meq promoter only in the presence of chicken c-Jun (CK-Jun) whereas Md5-Meq activated the same promoter irrespective of CK-Jun co-expression. However, Meq proteins of both Md5 and CVI988 bound the meq promoter in a ChIP assay regardless of whether CK-Jun was co-expressed or not. Domain swapping experiment indicated that both DNA binding and transactivation domains of Md5 Meq are essential for its full transactivation function. Further, site-directed mutagenesis of the Md5-Meq protein showed that amino acid residues at positions 71 and 320 are necessary for increasing transcription from its own promoter. All three Meq proteins activated the MDV gB, MMP-3 and Bcl-2 promoters and suppressed transcription from the MDV pp38/pp14 bidirectional promoter. Collectively, our data suggest that CVI-Meq proteins are generally weak transactivators, what might contribute to non-oncogenic phenotype of CVI988 virus in chickens.


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Autonomous and electrical truck maker Einride is rolling into Germany, representing its first new market in Europe outdoors its native Sweden.
Based out of Stockholm in 2016, Einride has raised some $150 million in funding to commercialize a cab-less autonomous cargo truck, one that may be managed remotely if required by human operators. It’s a notable departure from the slew of rival autonomous trucking firms on the market, that are primarily retrofitting current vans for an autonomous world — Einride’s vans are customized constructed for autonomy, with no bodily house for a human driver to even sit.
Whereas these so-called “pods” have been absolutely piloted with industrial purchasers, regulatory hurdles has meant that Einride has needed to provide human-driven electrical vans as a part of the transition to full-autonomy, which can be found to shippers and carriers in Sweden and within the U.S., the place it launched final yr, alongside its software-based Saga platform for operating and optimizing fleets.
It’s additionally price noting that Einride is gearing as much as deploy its absolutely autonomous pods on U.S. public roads in partnership with Normal Electrical Home equipment (GEA), with imminent plans to start out working on a mile-long stretch of street between GEA’s manufacturing facility and a warehouse in Selmer, Tennessee.
Einride has attracted a reasonably high-profile roster of early prospects along with GEA, together with Oatly, Past Meat, Bridgestone, and Maersk, the latter representing Einride’s largest order for electrical transportation globally, with the Danish delivery firm set to roll out some 300 vans throughout Los Angeles, Chicago and New York.
With its German launch, Einride is launching a regional workplace in Berlin, with plans to create logistics hubs in different key metropolitan areas. This may also require a purpose-built charging grid, which Einride stated it should create alongside Germany’s most essential industrial routes and neighboring commerce areas.
Einride is teaming up with residence equipment manufacturing big Electrolux for its German launch, which can work with Einride towards constructing the charging infrastructure at its warehousing amenities.
“Past this primary partnership, we are going to concentrate on metropolitan areas such because the Ruhr space, Hamburg, Berlin, the place we’re planning on constructing our personal charging community alongside main commerce routes to help additional potential companions with their fleet transformation,” Einride CEO Robert Falck defined to TechCrunch. “To start with, our focus is on three predominant operational areas: the distribution of partial masses, shuttles between distribution facilities and crops, and the electrification of the primary and final mile of intermodal transports.”
However whereas the preliminary focus will likely be squarely on its electrical vans, automation through its self-driving pods will likely be subsequent on the agenda.
“As we increase our presence and buyer record in German-speaking nations (Germany, Austria, and Switzerland), we’re additionally trying ahead to discovering native companions who’re able to implement preliminary pilot initiatives with the Einride Pod, as now we have already completed in Sweden and the USA,” Falck added.
As one in every of Europe’s largest economies and a freight and logistics powerhouses spanning street and sea, Germany represents an apparent growth for Einride within the European market. On high of that, in the present day’s announcement comes a yr after Germany primarily greenlighted driverless autos on public roads, although the ultimate laws continues to be winding its method by the related regulatory processes.
“Germany is within the driving seat of Europe — the place it goes, others comply with swimsuit,” Falck stated. “We’ve the chance and know-how to carry the most important change to the freight business for the reason that invention of the interior combustion engine, and are prepared to affix forces with native companions to make transportation historical past.”

domain: economics


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TomTom has the most accurate maps and with TomTom Map Share technology you can instantly modify street names, street direction, POIs, and more on your own device and receive daily verified updates from TomTom. Spoken turn-by-turn instructions and 3D graphics will guide you to any address in the US and Canada, worry free. Lifetime Traffic & Map Updates Enjoy a lifetime of easy driving with two great features from TomTom. LIFETIME Maps guarantees you receive four new editions of your TomTom map each year to ensure that you are always navigating with the industry's most up-to-date map. And, LIFETIME Traffic sends updates to your TomTom every three minutes, so you can always steer clear of traffic delays and take the fastest route possible to your destination. 7 Million POIs Preloaded with more than 7 million points of interest in over 60 destination categories. Easily find millions of gas stations, restaurants, hotels, ATMs and more on your route. 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The EasyPort mount makes your device even more portable so you can take it with you wherever you travel. *Feature available in the US and Canada only**Feature available in the US only" All TomToms Feature Plug & Go--Works right out of the box. 30 Day Latest Map Guarantee--Up to date, off the shelf. TomTom Map Share--Modify your own map and benefit from others' verified changes with TomTom Map Share. Help Me! Emergency Menu--Easily access local emergency providers such as police, fire stations and hospitals. TomTom HOME--Always up to date. Fuel Price Service (optional)--Know more, pay less. What's in the Box XL 335TM GPS device, EasyPort mount, USB cable, adhesive disk, car charger w/ integrated traffic, and user guide + LT maps voucher About TomTom Founded in Amsterdam in 1991, TomTom has established itself as a global leader in navigation by being an innovative company with a strong brand, clear customer focus, and high quality products and services. TomTom is the world's leading navigation solutions provider with navigation products sold in 30 countries and in over 20 languages. To further our commitment to car navigation, TomTom acquired Tele Atlas maps in 2008 so we can continually provide the most up-to-date maps and intelligent routing. We have our own mapping company! Did you know that every year roads change by up to 40% in high-growth areas? Tele Atlas manages this by using the world's most comprehensive systems to identify and incorporate these changes into our maps with unprecedented levels of speed and accuracy. All TomTom devices benefit from the Tele Atlas advantage--more coverage, more points of interest, and more freshness and accuracy. Why TomTom? At TomTom, we believe that personal navigation should be as easy and safe as possible. We develop smart technology that gives you straightforward solutions, innovations to make life easy.

domain: geography


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Bainbridge superintendent backpedals on Commodore closure
BAINBRIDGE ISLAND — Bainbridge school officials are breathing a sigh of relief now that the Legislature has passed a bill allowing school districts to maintain higher local levy collections.
Approval of the measure represents an estimated $1.1 million in revenue for the upcoming school year that Bainbridge Island School District will be able to collect after all. But the district isn't out of the woods, Superintendent Peter Bang-Knudsen told a crowd of more than 100 parents at Thursday's school board meeting.
With district enrollment falling, about $2.1 million in cuts must still be made. Bang-Knudsen is backing down, however, from his recommendation to close the Commodore Options building this fall and disperse the alternative learning programs it houses to other schools in the district.
Bang-Knudsen's announcement of the proposal — coming three days after the Feb. 14 passage of local levies for school operations and technology — was met with a strident outcry from Commodore Options parents.
"The compressed timing of it was a big concern," Bang-Knudsen said Thursday, explaining his recommendation to defer any action on the Commodore building until the 2018-19 school year.
The building houses the Odyssey Multiage Program, for students in grades 1 through 8, Eagle Harbor High School, and the Mosaic homeschool support program.
The district calculated it could save half a million dollars or more by moving Eagle Harbor into Bainbridge High School, splitting Odyssey students between Ordway Elementary School and Woodward Middle School, and finding a new home for the Mosaic program. Moving programs into other school buildings would create efficiencies and allow for growth of the popular Options programs, Bang-Knudsen said in his original announcement.
But parents pushed back, saying separation would kill the synergy of the Commodore community. That message was reiterated Thursday in nearly two hours of testimony before the board.
"If you bust up Commodore, you're not going to have that strong community. You're going to have divisions," said Emily Grice, who's been involved with Eagle Harbor for 16 years. "We are not a mini-Bainbridge High School. To put them as part of the high school dilutes that. It makes a conflict within the school."
Caty Kehs raved about the Mosaic program. Like other parents, she described a cohesive support network of staff, parents and students across all three programs. "It's beyond anything I've experienced anywhere," she said. "The community we have is frankly irreplaceable. ... We have different reasons for being there, but we all appreciate each other's differences."
Parent Rhett Stevens said the wait list at Odyssey is testimony to the program's success. "We are drawing people from private schools," he said. "We're drawing people from off the island, even out of state. ... You can see how successful the programs are. You can see the potential they have for drawing enrollment to the district."
"If we didn't have Commodore Options, we would be one of the families that looked outside Bainbridge Island School District for options," said Scott Daniels, whose son goes to Eagle Harbor. "After 10 years of success, dismantling Commodore so quickly is irresponsible, frankly."
Student Gus Beer, a 10th grader at Eagle Harbor, said it would be great to grow the Options programs, but they need to have their own space. He applauded the recommendation to delay any move for a year. "We need to find a place where all the different parts of the options programs can coexist," he said.
Kirsten Hytopoulos said the proposal to close the Commodore building was not new. A reconfiguration committee in 2013 opposed doing so. Hytopoulos urged the board to formally accept Bang-Knudsen's recommendation and relieve families' anxiety.
Bang-Knudsen and the board took heat for the timing of the original announcement. Bang-Knudsen has said the district knew since August it was heading into the red.
"The timing and public relations feels bungled at best," said Kelly Muldrow.
But a number of parents thanked Bang-Knudsen for his willingness to change course.
The board did not formally endorse Bang-Knudsen's recommendation to delay any action on Commodore for a year. Board members said they need more information and more time to weigh the options. The traditional budget trimming option would be to reduce staffing in line with enrollment and to make program cuts throughout the district. Since staffing makes up 86 percent of the district's budget it's likely there will be layoffs, even if the Commodore building is closed.
"Until I know what Option 1 looks like, I don't think it's responsible to take Option 2 off the table," said school board President Sheila Jakubik.
The district's budget advisory committee will continue meeting and make recommendations to the board. The board's decision on cuts is expected by April 14.

domain: news


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More Articles for Alan Sims
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No one cares about your Best of 2011 list. It's all opinion, with the reader left unhappy when their favorite album is left off or when they don't agree with the selections the writer comes up with.
That being said, this is not a Best of 2011 list. This is a list of new albums, EP's and singles that classic artists released in the last 365 days. With over 40+ releases this past year, the HIPHOPGODS were definitely putting in work.
The projects below are in alphabetical order and each comes with a link to purchase the music. After all the classic work these artists have put in, it's only right to get out there and support!
Armageddon http://itunes.apple.com/us/album/the-journal-vol.-1-rebirth/id435743340 "The Journal, Vol. 1: Rebirth"
Arrested Development http://itunes.appRead more
Raekwon has started off 2012 by dropping his Unexpected Victory mixtape.
Originally slated for release on Christmas Day, the 17-track project features appearances from Mobb Deep, CL Smooth, Busta Rhymes, plus production from the likes of 9th Wonder, Scram Jones and Statik Selektah.
In promotion for the project, Raekwon collaborated with New York-based company Mighty Healthy to release a collection of limited edition shirts bearing his name and the name of the mixtape, all positioned behind a gold microphone. Only 100 shirts were printed and made available to those who purchased a hard copy of 'Unexpected Victory.'
Download the Unexpected Victory mixture here: http://www.datpiff.com/Raekwon-Unexpected-Victory-mixtape.295793.html and check out the official track list below:
1. UnRead more
TIM EINENKEL: First off, how does it feel to have Kay Gee back in the group?
VIN ROCK: Yeah, it’s good, man. You know, we all started this group in high school basically. So, you know, we assemble ourselves, no one put us together and we’ve always been in control of what we did. So, when we lost Kay as a producer and DJ and you know, not only did we lose him from the studio perspective, we lost him from the stage perspective, as well as personally. When Kay got back in the mix it was a great thing to have an old friend back plus all of that talent.
TIM EINENKEL: This is your 7th album, Anthem Inc., and you guys have been together and in the game for so long. Has the process of making the album changed?
VIN ROCK: Nah, nah. Not really. Pretty much the same, you know. Kay is atRead more
Legendary Hip-Hop group The Sugar Hill Gang, R&B veterans The Moments and the executors of the Estate of Sylvia Robinson have filed a lawsuit against Universal Music Group, claiming the major label owes unpaid royalties.
The lawsuit, which was filed in The Supreme Court of the State of New York, claims that Universal has been withholding royalties from the legendary label, as well as the group members of The Sugar Hill Gang and The Moments.
The lawsuit states that Universal has ignored agreements with the Sugar Hill label, some which date back as far as 1969, when the company Sylvia Robinson was running was known as All Platinum Inc.
All Platinum was Sylvia Robinson’s label and counted artists The Moments, The Whatnauts and Robinson herself, as featured talent on the label.
Dubbed as both the Operation Skid Row Music Festival and the Occupy Skid Row Music Festival, on January 15th Chuck D and Public Enemy, along with a dozen or more (mostly old school Los Angeles) hip-hop acts will put on a free concert for the down-on-their-luck residents of Los Angeles' desolate Skid Row district.
The list of other performers for this incredible all afternoon event, that will also be open for free to anyone from anywhere who wishes to attend, includes Cypress Hill, Kurupt from The Dogg Pound, Mellow Man Ace and The ZZYZZX, King T, Rapper's Rapp Group, Sir Jinx and General Population, OG Kid Frost, L.A. Posse, and the Egyptian Lover.
What makes this concert significant is that all of these artists have agreed to perform for free as a an unselfish token in this new yearRead more
Blue Ivy Carter is only two days old and already she is featured on her proud father's latest record.
Jay-Z posted the latest track, "Glory feat. B.I.C.," on his Life + Times website Monday morning. The song concludes with sounds of a newborn crying.
Elsewhere during the cut, Jay makes some heartbreaking, as well as some sweet, revelations. "Last time, the miscarriage was so tragic," he raps. "We was afraid you disappeared, but nah, dear, you magic."
You can hear the joy all throughout the song: "The most amazing feeling I feel," he raps. "Words can't describe what I'm feeling for real / Baby, I paint the sky blue / My greatest creation was you."
Check out the song at the following link and congratulations to Jay-Z and Beyonce. http://lifeandtimes.com/glory-feat-b-i-cRead more

domain: entertainment


Known for imagination, a graceful, elegant style and exquisite technique, Stewart Goodyear is an accomplished young artist whose career spans many genres—concerto soloist, chamber musician, recitalist and composer.
Mr. Goodyear has performed with many of the major orchestras of the world—including six separate appearances to date with the Philadelphia Orchestra, in addition to performances with the New York Philharmonic, the Chicago Symphony, the Pittsburgh Symphony, the San Francisco Symphony, the Los Angeles Philharmonic, the Cleveland Orchestra, the Academy of St Martin-in-the-Fields, the Bournemouth Symphony, the Montreal Symphony, the Dallas Symphony, the Atlanta Symphony, the Detroit Symphony, the Seattle Symphony and the Mostly Mozart Festival Orchestra among others.
Mr. Goodyear also continues his vibrant partnership with the Cincinnati Symphony Orchestra and its Music Director, Paavo Jarvi with whom he appears frequently.
Highlights of this past season include subscription debuts with the Milwaukee Symphony Orchestra, the Royal Liverpool Philharmonic Orchestra, and the BBC Scottish Symphony Orchestra, and returns on main season concerts to the Chicago Symphony, the Philadelphia Orchestra, the Cincinnati Symphony, the Calgary Philharmonic, the Winnipeg Symphony and many others. Mr. Goodyear also performed the 32 late Beethoven Sonatas in their entirety at the Ottowa Chamber Music Festival, to great critical acclaim. All 32 Sonatas will be released in August 2010 on the Marquis Classics label.
Conductors with whom Mr. Goodyear has collaborated are Christoph Eschenbach, Daniel Barenboim, Michael Tilson Thomas, Sir Andrew Davis, Jukka-Pekka Saraste, Andrew Litton, Yakov Kreizberg, Emmanuel Krivine, Charles Dutoit, Pinchas Zukerman, Jun Markl, Hugh Wolff, Stefan Sanderling, JoAnn Falletta, Gerard Schwarz, Peter Oundjian, Miguel Harth-Bedoya, and Roberto Minczuk.
He has appeared in recitals in New York, Chicago, San Francisco, Atlanta, Bad Kissingen, and at the Kennedy Center in Washington DC; and he has performed with the Festivals of Caramoor, Santa Fe, and Ravinia.
In addition to his talents as a pianist, Stewart is a composer and frequently performs his own works, including his solo piano work, "Variations on 'Eleanor Rigby',” which premiered at Lincoln Center in New York in August 2000, and his Piano Sonata, both of which have received continual acclaim by critics and audiences alike. He has written by commission for the Toronto Youth Symphony for its 25th anniversary, as well as for the Santa Fe Chamber Music Festival. His piano Concerto was premiered this past August at the Peninsula Music Festival, and the Cincinnati Symphony has commissioned him to compose a fanfare in honor of Paavo Jarvi’s last season with the Orchestra. A new work for chorus was premiered by the Nathaniel Dette chorale of Canada in Toronto (June 2005).
Stewart has been noted for his innovation and is one of the rare classical musicians to always improvise his cadenzas when performing concertos from the classical period. He has been repeatedly praised for both the inspiring individuality and appreciation of the composer’s own style that he clearly conveys in every performance.
A native of Toronto, Stewart holds a Masters Degree from the Juilliard School of Music studying with Oxana Yablonskaya. He previously studied at the Curtis Institute of Music with Leon Fleisher, Gary Graffman and Claude Frank.
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You searched for: Access Public Remove constraint Access: Public Year 1863 Remove constraint Year: 1863
1 - 15 of 15
1. A plan of the city of New-York; drawn by Major Holland, Surveyor General. 1776.
1863. Holland, Samuel, 1728-1801. Facsimile. Relief shown by hachures. Indexed. "Engr. for D.T. Valentine's Manual 1863 ..." From "Valentine's manual of the City of New York". 1 map...
2. Bird's eye view of Charleston, South Carolina, and its environs, showing the scene of General Gilmore's [sic] operations.
1863. Harper & Brothers. Pages 515-6 of the August 15, 1863 issue of Harper's Weekly. Text on verso. 1 view: col.; 23 x 35 cm. This map is in the public domain. Please attr...
3. Bunkyū kaikoku hanʼei Kyōto onʼezu zusho narabini kōtei Yomo Shunsui.
1863. Yomo, Shunsui.,Hiranoya, Mohē. Mounted cover title. Wood block print. Oriented with north to the left. In Japanese. Relief shown pictorially. Includes legend. Engraved by Nakamur...
4. Carta general de la republica mexicana; formada por Antonio Garcia y Cubas.
1863. García y Cubas, Antonio, 1832-1912. Relief shown by hachures. "J.M. Munozguren grabo en piedra en Mexico." Inset: Plano de los caminos de Mexico a Vera Cruz con el rayecto del ferroca...
5. Carta Topografica Dell'agro Romano e Territori Limitrofi in Scala Di 1 a 80.000, 1880
1863. Digital Social Science Center (DSSC), Columbia University Libraries, Canevari, Raffaello., and Lit. Virano e Teano. This is a scanned version of the 1880 paper map series entitled: Carta Topografica Dell'agro Romano e Territori Limitrofi in Scala Di 1 a 80.000. ... Lit. Virano e Teano.
1863. Weyss, J. E. Scale [1:21,120]. 3 in. to 1 mile; 1 map: mounted on cloth; 56 x 62 cm Chancellorsville, Battle of, Chancellorsville, Va., 1863--Maps.
1863. Walker, Jr., Samuel. Scale approximately 1:15,000,000 (E 68°09ʹ00ʺ--E 92°41ʹ00ʺ/N 32°53ʹ00ʺ--N 6°45ʹ00ʺ). Prime meridian: Greenwich. 19 x 23 cm.
8. International Settlement, China, 1863-1899
1863. Henriot, Christian. This polygon shapefile represents international settlement in China from 1863 to 1899. This layer was created as part of the Grave Reform in Modern... Stanford University. Center for Interdisciplinary Research.
9. Kaei kaisei Sakai ōezu zen; Hosokawa Minamoto Yasuyoshi.
1863. Hosokawa, Yasuyoshi.,Suharaya, Mohē, 1731-1782. Title from mounted label on verso. Wood block print. In Japanese. Oriented with north to the upper right. Includes distance chart, products legend,...
10. Kashmir route map
1863. Scale 1:2,027,520. 32 miles = 1 in. ; (E 70°30ʹ00ʺ--E 80°30ʹ00ʺ/N 36°59ʹ00ʺ--N 28°30ʹ00ʺ). Relief shown by spot heights. "Lithog'd. and printed by ...
11. Map of battlefield of Big Black River Bridge, Mississippi, showing the positions of the U.S. troops, May 17th 1863
1863. Mason, F. (Act. Asst. Engineer). Scale approximately 1:7,200; 1 map: color; 49 x 45 cm Big Black River (Miss.)--History--Civil War, 1861-1865--Maps.
12. Map of Chicago, showing original subdivisions, 1863 to 1879 /prepared by Homer Hoyt from ante-fire plats of the Chicago Title and Trust Company.
1863. University of Chicago Social Science Research Committee. Scale approximately 1:175,300; Master and use copy. Digital master created according to Benchmark for Faithful Reproductions of Monographs and Seri...
13. Section of G. Woolworth Colton's New guide map of the United States and Canada, with railroads, counties, etc. 1863 : used by General Grant in marking the proposed lines of operations of the armies of the United States, in 1864
1863. Colton, G. Woolworth (George Woolworth), 1827-1901. Scale 1:3,168,000. Statute miles, 50 to one inch; maps: color; 42 x 69 cm Railroads--Southern States--Maps.
14. Sketch of the public surveys in the state of Minnesota
1863. United States. General Land Office. Scale 1:1,040,480. "St. Paul, October 19th, 1863." Above neat line at right: "Ho. Reps. ex. doc. no. 1, 38th Cong., 1st sess." Shows surveyed area ...
15. The middle Tennessee and Chattanooga campaigns of June, July, August and September 1863
1863. United States. Army. Corps of Engineers. Chattanooga, Battle of, Chattanooga, Tenn., 1863--Maps.

domain: library


text:
Give listen to my wordings!
I’m not your pastor,
Just a preacher driven by Passion.
I hate to say this, but it’s an habit;
To dance and sing and still not get it.
We do, as a likely solution to our mysteries, yet in our miseries we live to regret it;
Not for bugging, but being wrong with it.
Being wrong — in living to please Him.
See, Jesus, He took my bills added yours settled it and claimed the Hons
– Called it redemption.
Opened my eyes to my favorite
– Renamed it temptation.
Left behind a handbook with history and instructions;
One that bounded me to this knowledge we term SALVATION.
Cos I had an orientation of who he was,
He made me into a friend.
We became more than friends, brothers.
He could feel my pain even more than I could his.
Once I thought it was just empathy
And didn’t really bother,
But he took the fall right there,
Proving it was LOVE , not a cover
Exercising it from the time of my first fall.
His love for me keeps tabs for my missed call.
What Christ did?
To the fools he became a fool,
To the wise he became unwise,
He became their initial payment
To satisfy them with a heart, Joy full.
What Christ did I cannot really explain,
He took my favorite and made it his pain.
If I say I love Jesus, you may say I’m insane;
Cos what He did wasn’t sane.
He took my place, my life – His gain
Offered it all, This dying world to regain.
After a brief study of His death and resurrection, what I term his glory,
I decided to paint my friend to you
– all from memory.
Let’s Imagine Christ together.
This celebration is incomplete without reviving History(His Story).
I stumbled upon this and I loved it.
Do well to share with friends!

domain: artistic


Murat Theatre | Indianapolis, Indiana
This spring, folk singer Ray LaMontagne is hitting the road for The Monovision Tour with special guest Sierra Ferrell in select cities. The New Hampshire native is performing for the first time his songs from the latest album, Monovision, released in 2020. On Tuesday, 24th May 2022, Ray LaMontagne and Sierra Ferrell will stop at the Murat Theatre. Fans can expect Montagne to cover songs from his new album and the catalog from his previous records. LaMontagne’s stop in Mura Theatre, Indianapolis, is just part of his 24-date tour across North America. Tickets are already on sale, and for those who are fans of folk-rock music, don’t miss out on this show because this Grammy-award-winning singer-songwriter is worth the trip!
Ray LaMontagne’s music has held meaning to fans since the early 2000s. His songs are frequently featured in romantic comedies or films. Some may be familiar with his tracks – “Hold You in My Arms” was featured in Amanda Byne’s movie She’s the Man, “Within You” and “Lesson Learned” was used in One Tree Hill, and “Be Here Now” was featured in the film 27 Dresses. Indeed, LaMontagne’s music seems perfect for official soundtracks, but as a solo artist who had quit his job for his craft, LaMontagne is more than just background music.
In 2011, LaMontagne recorded his fourth album, God Willin’ and the Creek Don’t Rise. The record was in collaboration with the Pariah Dogs, which is the first time he brought guest artists into the studio with him. The album was nominated by two Grammy Award categories and won a Grammy Award for Best Contemporary Folk Album. The album’s lead single, “Beg Steal or Borrow, “ was nominated for Song of the Year.
In 2020, LaMontagne released his newest album, Monovision, via RCA Records. Monovision was highly acclaimed by fans and critics. A writer from Riff Magazine wrote that Monovision is “overflowing with LaMontagne’s unadorned and earnest sincerity.” The album’s first single, “We’ll Make It Through,” seems to sound like another perfect song for a romantic film soundtrack, but critics have praised it for its striking lyrics and bittersweet melody. The writer from Riff likened it to a “gentle dad who’s not mad at you even though you spilled your Big Gulp in his truck.
Whether you know love Ray LaMontagne because he sang the song to your favorite TV show or film, or because he sang the soundtrack of your life, you must take this chance to go see him at the Murat Theatre! Tickets to see Ray LaMontagne and Sierra Ferrel are now available!


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Limited time offer for early subscribers!
Sign up today to show your support for SAK’D and we’ll reward you with early-backer crowdfunding notification and pre-order discounts on the game when our crowdfunding campaign begins. You’ll also receive exclusive behind-the-scenes sneak-peeks at the game and related materials in-progress, as well as major development team production updates. Learn more!

domain: game


FALLS CHURCH, Va. (AP) — A hand surgeon testified Monday that Johnny Depp could not have lost the tip of his middle finger the way he told jurors in his civil suit against his ex-wife Amber Heard.
The finger injury that occurred between Depp and Heard in Australia in March 2015 was one of several issues in the lawsuit. Depp says he was injured when Heard threw a vodka bottle at him. Heard has said she never saw exactly how it happened, but that it happened one night when an angry dork sexually assaulted her with a liquor bottle.
Depp is suing Heard for defamation in Fairfax County Circuit Court over a December 2018 comment she wrote in the Washington Post describing herself as “a public figure who advocates domestic violence.” His lawyers say he was defamed by the article, although he never mentioned his name.
Depp has denied ever hitting Heard and says she was the perpetrator of the relationship. Heard has testified about more than a dozen counts of physical abuse she allegedly suffered at Depp’s hands.
On Monday, surgeon Richard Moore testified about the severed finger when jurors saw gruesome photos of the injury. He said Depp described having his palm on a pole when it was hit by the bottle.
Moore, who did not treat Depp, testified that Depp’s description was unlikely, in large part because his fingernail remained intact. Moore said the fingernail was exposed when Depp described the placement of his hand and was damaged. Moore also said the rest of his hand would have had other cuts from the glass, which shattered on impact.
While Depp told jurors Heard severed his finger by throwing a vodka bottle, at the time of the accident he was telling people and texting that he did it to himself. He once said the finger had been pinched between solid accordion doors.
Depp now says he lied to protect Heard. Moore testified that pinching the finger in accordion doors would be consistent with the injury.
The process is now in its sixth week. Monday’s testimony was relatively mundane in a trial that has given an ugly glimpse into the couple’s toxic relationship. There was an expectation that Heard’s attorneys would call Depp to the witness stand Monday, but that didn’t materialize. Heard’s attorney, Elaine Bredehoft, said at the end of the day Monday that they are still debating whether to call him.
The jury had already heard extensively from Depp and Heard – each on the witness stand for four days and subjected to grueling cross-examination.
Also on Monday, a psychiatrist testified that Depp’s behavior fits the pattern of someone whose drug and alcohol abuse contributes to domestic violence.
Depp’s attorney, Wayne Dennison, questioned the ethics and credibility of the psychiatrist’s opinions because he had never examined Depp.
Later Monday, Dennison questioned another Heard witness, entertainment expert Kathryn Arnold, at length about her claim that Heard lost a potential $40 million to $50 million when another Depp attorney called Heard’s abuse allegations a “hoax.” Heard has filed counterclaims against Depp based on these statements.
Arnold said she compared Heard’s career to “comparable” stars like Gal Gadot, Jason Momoa and Zendaya to show where Heard’s career would have gone had Depp’s attorney Adam Waldman not defamed her.
Dennison scoffed at the idea that Heard was in the same league as these stars during his questioning. He also turned down Heard’s role as Mera in the superhero film series Aquaman, saying that the forthcoming Aquaman sequel is more of a “buddy comedy” than a film in which Heard will play a romantic lead.
Heard “was on the brink of a great career,” Arnold said.
The trial has attracted increasing public attention over its duration. People camped out overnight, fighting for places in line as they tried to get one of the 100 courtroom seats allocated to the public. During a morning break, a woman professed her love for Depp and asked when he would acknowledge that he was the father of the baby she was holding.
She was removed from the courtroom.


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Décor Inspiration | Interior Designer: Gérard Faivre Paris
Thursday 12th November, 2015
by TIG Studio
Much like last’s week’s Parisian apartment just on the market, Gérard Faivre Paris offers fully renovated, ready to live, stunning apartments for sale in Paris. The spaces, never before occupied, have been labelled Art Homes by the company, their interior design rendering them works of art. Finding the perfect Paris apartment can often take more than two years to complete: after searching for a property, acquiring, renovating and decorating. Gérard Faivre aims to reduce this time frame to two months, offering the possibility of moving into a beautiful space without all the usual burdens . . .


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Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (860K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
These references are in PubMed. This may not be the complete list of references from this article.
BUCKLE RM. THE GLYOXYLIC ACID CONTENT OF HUMAN BLOOD AND ITS RELATIONSHIP TO THIAMINE DEFICIENCY. Clin Sci. 1963 Oct;25:207–217.[PubMed]
CAVALLINI D, FRONTALI N, TOSCHI G. Keto-acid content of human blood and urine. Nature. 1949 Nov 5;164(4175):792–792.[PubMed]
EARL CJ, EL HAWARY MFS, THOMPSON RHS, WEBSTER GR. Blood-pyruvate levels in subacute combined degeneration of cord; effect of vitamin B12 therapy. Lancet. 1953 Jan 17;1(6751):115–116.[PubMed]
EL HAWARY MFS, THOMPSON RHS. Separation and estimation of blood keto acids by paper chromatography. Biochem J. 1953 Feb;53(3):340–347.[PubMed]
HORNABROOK RW, MARKS V. The effect of vitamin-B1 therapy on blood-pyruvate levels in subacute combined degeneration of the cord. Lancet. 1960 Oct 22;2(7156):893–895.[PubMed]
JOINER CL, McARDLE B, THOMPSON RHS. Blood pyruvate estimations in the diagnosis and treatment of polyneuritis. Brain. 1950 Dec;73(4):431–452.[PubMed]
LING CT, CHOW BF. Effect of vitamin B12 on the body composition of rats. J Biol Chem. 1952 Sep;198(1):439–444.[PubMed]
MCARDLE B. The quantitative estimation of pyruvic and alpha-oxoglutaric acids by paper chromatography in blood, urine and cerebrospinal fluid. Biochem J. 1957 May;66(1):144–148.[PubMed]
MARSTON HR, ALLEN SH, SMITH RM. Primary metabolic defect supervening on vitamin B12 deficiency in the sheep. Nature. 1961 Jun 17;190:1085–1091.[PubMed]
Peters RA, Wakelin RW. Observations on the relation between sulphydryl groups and pyruvate oxidation in brain tissue. Biochem J. 1946;40(4):513–516.[PubMed]
PHILLIPS GB, VICTOR M, ADAMS RD, DAVIDSON CS. A study of the nutritional defect in Wernicke's syndrome; the effect of a purified diet, thiamine, and other vitamins on the clinical manifestations. J Clin Invest. 1952 Oct;31(10):859–871.[PMC free article][PubMed]
REGISTER UD. Effect of vitamin B12 on liver and blood non-protein sulfhydryl compounds. J Biol Chem. 1954 Feb;206(2):705–709.[PubMed]
Articles from Proceedings of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press

domain: literature


text:
- FAQs Find a Health Professional
Ovarian cysts are fluid-filled sacs (pockets) that can occur inside or on the surface of the ovaries (the two small organs that produce eggs (ova) in women). Ovarian cysts are quite common in women of childbearing age.
Women have two ovaries - one on either side of their womb (uterus). Their function is to develop eggs and produce female sex hormones. You can develop one or more cysts on either one of your ovaries or on both ovaries at the same time. If a number of cysts (usually at least 10) develop around the outside of an ovary, it is called polycystic ovary syndrome.
Types of ovarian cyst
There are several different types of ovarian cyst. The most common are called functional cysts. Functional cysts develop as a woman goes through her menstrual cycle. The eggs in a woman’s ovary develop inside small swellings called follicles. Every month, one of these follicles grows larger, until it eventually bursts, releasing the egg. Functional cysts develop from these follicles. They include:
- follicular cysts - these develop when the follicle fails to burst
- corpus luteum - this is formed when the egg has been released by the follicle, but the follicle fails to break down - instead it becomes filled with fluid or blood
These types of cyst tend to go away by themselves.
Other types of ovarian cyst don´t form during the menstrual cycle, but are due to unusual growth of cells in the ovary. These include:
- cystadenomas - these are formed from cells that cover the outer surface of the ovary - they can be filled with a watery liquid (serous cystadenoma) or a thicker, sticky fluid (mucinous cystadenoma)
- dermoid cysts - these develop from the cells that make eggs in the ovary - they may contain several types of tissue, including hair, teeth and other material
- endometriomas - these are often associated with endometriosis and form when endometrial tissue (the cells lining the womb) starts to grow in the ovaries
These types of cyst may also be referred to as ovarian tumours. A tumour just means an uncontrolled growth of cells. Most ovarian tumours are benign (they aren’t cancerous, and don’t invade other tissues or spread to other parts of the body).
However, a tumour may occasionally turn out to be malignant (cancerous). This means it may spread to other parts of the body and invade surrounding tissue. This is why it is important that all cysts are checked by your doctor.
Causes of ovarian cysts
It is not known at present why some women develop ovarian cysts. Some medicines used for the treatment of infertility can sometimes trigger the development of follicular cysts.
Symptoms of ovarian cysts
Most ovarian cysts don't cause any symptoms at all, so you may not even realise you have one. However, depending on the type of cyst you have, it is possible that you may get some of the following symptoms:
- pain - it is rare for a cyst to be painful, but you may sometimes feel a dull or sharp ache in your lower abdomen (tummy), or pain during sexual intercourse
- discomfort, if your cyst grows quite large
- having to pass urine more often, or sometimes finding it harder to pass urine (urinary retention)
- a feeling of pressure or fullness in your lower abdomen/pelvis
- menstrual changes, such as longer or heavier periods than usual, or sometimes shorter periods than usual
These symptoms aren´t always due to ovarian cysts, but if you have them, you should visit your doctor.
Occasionally, a cyst can twist (this is called torsion) or suddenly burst (rupture). This can cause severe pain in your abdomen. You may also feel sick or vomit. You should seek urgent medical attention if you have been diagnosed with a cyst and get a sudden severe pain in your abdomen. You may need to have hospital treatment if you have a twisted or burst cyst.
Diagnosis of ovarian cysts
As you may not have any symptoms from your ovarian cyst, it may only be discovered if you are having an examination or ultrasound scan for some other reason.
If you visit your doctor with symptoms of an ovarian cyst, he or she will ask about your symptoms and conduct an internal examination. Your doctor may be able to feel a swelling on your ovary if you have an ovarian cyst.
If your cyst is large or your doctor thinks it needs further investigation, he or she will refer you to a gynaecologist - a doctor specialising in women’s reproductive health.
You will usually need to have further tests to diagnose an ovarian cyst. These may include the following.
An ultrasound - this uses sound waves to produce an image of the inside of the body or part of the body. A radiologist (a doctor who specialises in using imaging methods to diagnose medical conditions) or radiographer (a health professional trained to perform imaging procedures) may perform this test. He or she will look at your ovarian cyst by placing an ultrasound probe on your lower abdomen, or sometimes into your vagina (transvaginal ultrasound), which can give a clearer picture of your ovaries.
Blood tests - these may be carried out for a substance called CA-125, which can be increased in women who have ovarian cancer or benign ovarian cysts.
Treatments of ovarian cysts
If your cyst is found to be quite small (less than 5 cm across), your doctor will probably just need to monitor it. It is likely to disappear on its own within a couple of months and not cause any problems.
You may be advised to take the contraceptive pill if you have a functional cyst, or if you are prone to getting them. The contraceptive pill can help to prevent this type of cyst.
If your cyst is large, causing you any pain or discomfort, or doesn´t start to go away after several weeks, your gynaecologist may suggest you have surgery to remove it. The extent and type of surgery you have will depend on many factors, including the size and type of cyst you have, your age and your desire to have children.
Ovarian cyst removal
Many women can have a procedure that involves just removing the cyst (without having to remove your ovary). If your cyst is small and unlikely to be malignant, it can be carried out as a day case using a type of surgery called laparoscopy (or keyhole surgery). This involves using tiny instruments inserted through small cuts in your skin to remove the cyst.
Some women need open surgery instead of a laparoscopy to remove their ovarian cyst. In this procedure, a larger cut is made in your abdomen in order to remove the cyst. Both types of procedure are done under general anaesthesia, which means you will be asleep during the operation.
If there is any doubt about whether your cyst is malignant (cancerous), your surgeon may advise that you have one or both of your ovaries and fallopian tubes removed, or a total hysterectomy (where your womb is removed too). This is an important decision because it will affect your ability to have children.
Whether your surgeon will advise this type of surgery depends on your age and the type of cyst you have. You will have an opportunity to talk to your surgeon about your options before your operation, and any surgery will only be carried out after you have signed a consent form. This confirms that you understand the risks, benefits and possible alternatives to the procedure and have given your permission for it to go ahead.
Frequently Asked Questions is currently not available.
Counter the Epidemic - COVID-19 Test and Doctor Video Consultation at Home To Keep Social Distancing


text:
Minister appeals her conviction for marrying gays
Updated 1:11 am, Friday, February 17, 2012
A 69-year-old lesbian minister, who has championed gay rights in the Presbyterian Church USA for decades, will defend herself today before the denomination's highest court for marrying 16 same-gender couples.
The hearing in a conference room at the Drury Plaza Hotel downtown is a final appeal by the Rev. Jane Spahr of San Francisco, who was convicted two years ago of violating her ordination vows and church policy that defines marriage as between a man and a woman.
The judicial commission has members from across the nation and rotates cities for its hearings. The denomination, based in Louisville, Ky., has more than 2 million members.
Two church courts censured Spahr as punishment for the weddings performed in 2008 in California, where gay marriage is legal. But they also praised her courage and noted that she was a faithful Christian, adding to confusion over whether the denomination's policies permit such weddings.
She argued that the Presbyterian constitution contains no ban on marrying committed couples in alternative lifestyles and that church doctrine advocates for social justice. Spahr, ordained in 1974, said she began to celebrate “holy unions” as if they were legal marriages.
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“When the church calls the gay, lesbian, bisexual and transsexual community second-class citizens and less than, then that's violence, and we want violence to stop,” she said Thursday shortly after arriving in San Antonio with friends, family and her legal team. “Of course, I want justice and love to come together here and for the church to be open and hospitable to same-gender couples.”
The issue of gay marriage has divided mainline denominations for decades, with a growing number of churches enacting policies to approve of same-gender ceremonies and gay clergy. Meanwhile, seven states and Washington, D.C., have legalized gay marriage, pressing the issue for these denominations to sort out policies for their own clergy.
The Presbyterian Church approved a policy last summer that allows congregations to hire gay clergy. It has prompted some congregations to leave the denomination while others have heralded it as a much-anticipated step toward equality.
Spahr, who is retired, will stand before a church judicial commission of about 14 people today. Their decision is expected on Tuesday, and many hope it will clarify whether Presbyterian clergy are permitted to perform gay marriages.


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OPM's proposal, published Wednesday in the Federal Register, provides a regulatory framework for agencies to obtain permission to offer better pay for positions that require specific expertise in the scientific, technical, professional or administrative fields.
The flexibility, designed to help attract and retain talented workers, is "underutilized," the notice stated.
OPM is in charge of granting permission for agencies to use the flexibility, in consultation with the Office of Management and Budget. Once agencies obtain the authority, they can set the rate of basic pay for a critical position up to that for level I of the Executive Schedule -- $186,600 for fiscal 2007. Agency heads can seek additional approval to offer higher pay rates if they justify the need to do so, the notice said.
Employees who receive critical position pay have no other changes in their conditions of employment, such as eligibility for performance awards and retention and relocation incentives, the notice said. But by law, such employees may not be eligible for locality pay.
"OPM staff can only speculate that the ban on locality pay for such positions was in consideration of the fact that critical pay already provided a higher rate of pay for the position than otherwise would apply," said Nancy Kichak, associate director of strategic human resources policy for OPM.
The proposal seeks to clarify what information agencies must provide to OPM to obtain the critical pay authority, including the position title, the pay plan and grade level, occupational series and geographic location of the position and the current salary of the position or the incumbent.
The proposal also requires agencies to submit annual reports to OPM regarding their use of the critical pay authority and whether such authority is still essential to the agency's ability to recruit and retain talented workers.
Kichak added that no General Schedule employees currently receive the critical pay. She said it can take several months for agencies to obtain approval, depending on the quality of the material submitted, the suitability of the position or candidate and other factors specific to the request.
Written comments on the proposal must be submitted by June 25, and can be sent by e-mail to email@example.com.

domain: law


text:
WE ARE PEOPLE WORKING FOR PEOPLE
Transform Chile into a pillar of the scientific and technological development of AI in Latin America and the world.
Our vision Cenia is the leading organization in Latin America in the scientific and technological development in AI, achieving worldwide recognition.
Our purpose Through progress in AI and its responsible use contribute to improving the quality of life of our society and individuals.
We are socially responsible. We develop AI solutions in a sustainable and ethical way, seeking to be a contribution through the Center’s developments to improve people’s quality of life. We are especially committed to bringing AI to communities with limited access to technology, through partnerships with public and private actors. Finally, we lead actions that seek to educate and communicate the benefits and risks of AI in various spaces.
Excellence We aspire to high excellence. We understand the importance of active and proactive participation. We develop with a genuine interest in contributing to others, giving our maximum effort in all our work.
We build relationships of trust among all our employees, promoting direct and transparent communication, in favor of inclusion, respect and empathy. We believe in understanding and tolerance. We value all people and reject all types of discrimination, harassment and violence.
We work to build a pleasant environment that promotes the exchange of ideas, knowledge and development of friendly relationships, taking care that the achievement of our objectives is carried out in a healthy and welcoming organization. We seek transparency in the ways of working of all teams and areas, we care that everyone has access and knowledge in how the Center works.

domain: sociology


(PRESS RELEASE VIA SNO) – The Minister for Home Affairs and National Security Senator the Honourable Hermangild Francis will lead a contingent to Venezuela on Friday, July 27, 2018 where he will meet with the Minister of the Popular Power for the Interior, Justice and Peace Mr. Nestor Luis Reverol and the Director of the National Anti- Drug Organization Mr. Juan Grillo Gonzales.
The Government of Saint Lucia has announced that visa requirements will be imposed on Venezuelans, with the exception of diplomats and genuine business persons. This action he says was precipitated by mounting national security concerns and the monitoring of unrelenting activities impacting the island’s porous borders.
Minister Francis explained that the Government has been very thorough in relation to responding to some of the spin-off challenges emerging from the country’s current unfortunate economic circumstances.
“Venezuela is still our friend. We are not attempting to embarrass any nation, but suffice it to say that it is incumbent on the Government to take measures that will protect the country from security threats, and not compromise the security of our citizens or our borders. So this visit signifies that we are still friends and we will discuss mutual concerns and explore any solutions for going forward.”
Minister Francis also calls on the public to trust the Government’s position, noting that it is not necessary to sensationalize this issue.
“This action is not unprecedented. It is not unprecedented that governments respond to their domestic concerns. We in Saint Lucia have visas imposed on us, and I speak of a country of less than 180,000 people.”
The entourage leaving for Venezuela will include the Acting Deputy Commissioner of Police Mr. Dorian O’Brian, Venezuela’s Ambassador to Saint Lucia Leiff Esconlona, and representatives of the Office of the Mayor of Castries.
Minister Francis says he is looking forward to favourable talks.


text:
Kids Doodle - Color & Draw is a drawing app aimed mainly at kids. It lets you use your finger to draw and paint whatever you want on the screen of your Android. Users of Kids Doodle can paint either on a white canvas or over a picture from your device's memory. Whichever option you choose, there are 18 different brushes you can use, including a fluorescent one and a spray brush. One of the most interesting options in Kids Doodle is the ability to create videos from your drawings. This mode lets you record a video of the drawing process so you can then watch it later. Naturally, the app includes undo and redo buttons, so you can correct any mistakes. Kids Doodle - Color & Draw is a comprehensive drawing app that offers quite attractive results. One of those perfect apps to keep kids busy for a good while.
Requires Android 2.2 or higher

domain: hobby


text:
Scotland’s landscape is punctuated with castles, each bearing witness to the country’s tumultuous history, architectural evolution, and the lore of its clans. From the iconic Eilean Donan to the majestic Edinburgh Castle, each fortress tells a story of clans, conflicts, and confluences that shaped Scotland.
This guide explores ten of the most captivating castles, offering insights into their historical significance and practical advice for visitors seeking to explore Scotland’s noble past.
These castles range from ruins whispering tales of yore to well-preserved fortresses that still celebrate the grandeur of Scottish nobility. Exploring these castles offers a glimpse into Scotland’s past and breathtaking views of its stunning natural scenery. This guide invites you on a tour of ten enchanting castles, unveiling the stories behind their stone walls and guiding you through the best ways to experience their timeless magic.
1. Eilean Donan Castle
Eilean Donan Castle, perched on an island at the point where three great sea lochs meet, and surrounded by the majestic landscapes of the Scottish Highlands, is one of the most iconic and photographed castles in Scotland. The original castle was built in the early 13th century as a defense against the Vikings. Over the centuries, it was destroyed and rebuilt multiple times, with the present castle dating back to the early 20th century. Today, Eilean Donan offers visitors a glimpse into Scotland’s medieval past, with its restored living quarters, banquet halls, and defensive structures that highlight the strategic importance of this site through the ages.
2. Edinburgh Castle
Dominating the skyline of Scotland’s capital, Edinburgh Castle is a historic fortress that embodies the spirit of Scotland. Perched atop Castle Rock, it offers panoramic views of Edinburgh and beyond. The castle has been a key military stronghold, royal residence, and prison throughout its history. Today, it houses Scotland’s Honours (Crown Jewels), the Stone of Destiny, and the National War Museum of Scotland. The castle’s rich history is palpable in every stone, from St. Margaret’s Chapel, the oldest surviving part of the castle, to the Great Hall and the Royal Palace.
3. Stirling Castle
Stirling Castle is one of Scotland’s largest and most important castles, both historically and architecturally. Situated on Castle Hill, it commands a strategic position overlooking the River Forth, and it was once a favored residence of the Stewart kings and queens. The castle is a symbol of Scottish independence and national pride, playing a pivotal role in the country’s history, notably during the Wars of Scottish Independence. Visitors can explore the Royal Palace, the Great Hall, and the Chapel Royal and enjoy stunning views of the surrounding countryside.
4. Urquhart Castle
On the shores of Loch Ness, Urquhart Castle offers visitors a rich history and one of the most picturesque settings in Scotland. Though now in ruins, the castle remains a compelling site for exploration, with its history stretching back to the 13th to 16th centuries. It played a significant role in the Wars of Scottish Independence and had a turbulent history until it was largely destroyed in 1692. The castle’s remains, including the tower house and the gatehouse, offer a fascinating glimpse into medieval Scotland, and the visitor center provides detailed exhibitions on the castle’s history and legends of Loch Ness.
5. Balmoral Castle
Balmoral Castle, located in Royal Deeside, Aberdeenshire, is the Scottish home of the British Royal Family. The castle was purchased by Queen Victoria in 1848 and has been a favorite residence for royal retreats. Unlike many of Scotland’s ancient castles, Balmoral is an example of Victorian architecture and is set amidst expansive estates, gardens, and woodlands, offering a glimpse into the private life of the monarchy. While the castle itself is not open to the public when the Royal Family is in residence, visitors can explore the estate, gardens, and the Ballroom, the only room in the castle that is open to the public, which houses exhibitions relating to the Royal Family’s connection to Scotland.
6. Dunrobin Castle
Dunrobin Castle, located in the northern Highlands near Golspie, is the largest house in the Highlands and one of Britain’s oldest continuously inhabited houses, dating back to the early 1300s. With its fairy-tale spires and stunning gardens modeled after those at Versailles, Dunrobin is the family seat of the Earls and Dukes of Sutherland. The castle’s architecture reflects various styles, having been expanded and remodeled several times throughout its history. Today, visitors can explore the 189 rooms, which feature period furnishings, family portraits, and collections of arms and armor. The castle’s gardens are a highlight, offering a tranquil setting with meticulously landscaped lawns and a variety of plant species.
7. Inveraray Castle
Inveraray Castle, the ancestral home of the Duke of Argyll, Chief of the Clan Campbell, stands on the shores of Loch Fyne in Argyll. This striking example of Gothic Revival architecture was completed in the late 18th century and is surrounded by 16 acres of gardens and beautiful wooded parkland. The castle’s interior is as impressive as its exterior, with elaborately decorated rooms that house a fine collection of weapons, tapestries, and other artifacts. The Armoury Hall, with its muskets and polearms display, is one of the most impressive in Scotland.
8. Glamis Castle
Glamis Castle, situated in the fertile valley of Strathmore, is the legendary setting of Shakespeare’s “Macbeth” and the childhood home of the Queen Mother. This stunning castle, with its turrets and towers, dates back to the 14th century, though the site has been occupied since the Dark Ages. Visitors to Glamis Castle can explore its history through guided tours that reveal tales of royalty, intrigue, and folklore, including the famous legend of the Monster of Glamis. The castle’s gardens and grounds are equally impressive, featuring Italianate terraces, a walled garden, and nature trails.
9. Cawdor Castle
Cawdor Castle is associated with Shakespeare’s “Macbeth,” although the castle dates from the late 14th century, well after the historical Macbeth. This picturesque castle is nestled in the Nairnshire countryside and is famed for its beautiful gardens, including the Walled Garden, the Flower Garden, and the Wild Garden. Inside, Cawdor Castle boasts a fine collection of Scottish and European art, antique furniture, and tapestries. The castle still serves as the Cawdor family home, adding a personal touch to its historic halls and chambers.
10. Caerlaverock Castle
With its distinctive triangular shape and moat, Caerlaverock Castle is one of Scotland’s most unique fortifications. Located in the Dumfries and Galloway region, this 13th-century castle is renowned for its striking architecture, including its massive twin-towered gatehouse and imposing battlements. The castle’s history is marked by sieges and conflicts, notably during the Wars of Scottish Independence. Today, Caerlaverock Castle stands partly in ruins, yet its grandeur and the beauty of its setting remain undiminished. Visitors can explore the castle’s interior, walk along its battlements, and learn about the rich history of the Maxwell family, who were long associated with Caerlaverock. The adjacent nature reserve also offers opportunities to enjoy the local wildlife and scenic beauty of the Solway Firth.
The Bottom Line
Venturing through Scotland’s enchanting castles is like stepping into a storybook with tales of intrigue, warfare, and beauty. As you trace the footsteps of kings, queens, and clansmen, you’re part of Scotland’s ongoing saga. So, pack your sense of adventure and set forth on a journey to discover the soul of Scotland through its most majestic castles. Whether shrouded in mist or basked in sunlight, each castle awaits with stories to tell and wonders to reveal.
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The post Are They Ghostly? 10 Enchanting Castles of Scotland to Explore was republished on Passing Thru with permission from The Green Voyage.
Featured Image Credit: Shutterstock / Benny Marty.
For transparency, this content was partly developed with AI assistance and carefully curated by an experienced editor to be informative and ensure accuracy.

domain: history


text:
Consumers€”not science€”are driving demand for antibiotic-free meat
Another day and another meat producer bows to ill-informed consumer pressure and announces it will be curbing or eliminating the use of antibiotics in livestock rearing.
Seizing on this as an opportunity, companies such as Tyson Foods and Perdue Farms Inc., retailers Wal-Mart Stores Inc. and BJ's Wholesale Club Inc., and fast food chains such as Chick-fil-A have jumped on the antibiotic-free bandwagon.
But questions remain including the feasibility and sustainability of raising livestock in an antibiotic-free environment in sufficient numbers to feed an ever-growing population of meat eaters and at what cost to consumers.
In a parallel universe, where we hadn't starved the American Indians from their lands by ruthlessly hunting herds of bison that thundered across the Great Plains several centuries ago, perhaps we'd all be enjoying lower-fat, denser, grass fed and wonderfully flavorful buffalo meat in our burgers at our family barbecues. But instead, to feed the 300 million or so meat eaters across the United States, we're left to the methods of a livestock industry that raises animals in close quarters under conditions that often cause disease to spread – hence the need for antibiotic treatments.
The challenge: raising healthy food-producing animals
The Wall Street Journal recently described the monumental task facing meat producers in light of an ever-increasing demand for meat:
"At current consumption rates, the world would need to generate 455 million metric tons of meat annually by 2050, when the global population is expected to reach 9.7 billion, from 7.3 billion today…"
Since the 1950s, antibiotics have been used routinely in the feed and drinking water of livestock raised for human consumption. This practice has resulted in animals being in better health overall as well as weighing more at the time of slaughter, an obvious financial benefit to the livestock farmer. The mechanism of this weight gain is not completely understood but, in addition to creating generally healthier animals, it is believed that continuously administering sub-therapeutic dosages of antibiotics results in better nutrient absorption.
But consumer advocates have raised two concerns neither of which is based in science: that there are antibiotic residues in the meat we eat and the continued use of antibiotics in livestock is responsible for the creation of antibiotic-resistant super bugs that can infect humans.
It has been against the law for decades to sell meat and other dairy products containing antibiotic residues. To put it simply, all meat sold in the U.S. is already antibiotic-free.
In a 2011 industry white paper published by the National Institute for Animal Agriculture titled "Antibiotic Use in Food Animals," the authors state: "If antibiotics are administered to cure a sick animal, the animal itself — in the case of meat production, or animal products, such as milk — is not allowed to enter the food supply until the withdrawal period has passed and the medicine has sufficiently cleared the animal's system. The required periods for withdrawing medication are specific for each drug and species and are approved by the FDA based on research studies of residues in edible tissues."
Perdue Farms all but admits this. On their website, they have posted the following disclaimer: "Chickens not raised for the organic and no-antibiotics-ever program are generally treated to prevent common intestinal illnesses using ionophores. Ionophores are a type of animal-only antibiotic not used in human medicine, and are not associated with antibacterial resistance in human medicine. As part of our animal welfare commitment, should animals become ill – including organic and no-antibiotics-ever – they will be treated as medically appropriate. However, if antibiotics are used, those animals are not marketed as no-antibiotics-ever or organic. In those rare cases, federally mandated withdrawal periods ensure products are free of antibiotic-residue as defined by the USDA."
Notwithstanding, public pressure on politicians and ultimately the US Food and Drug Administration came to a head in December 2012 when the FDA published voluntary guidelines calling on the industry to observe more prudent use of antibiotics and to work toward their complete withdrawal at the growth promotion level. Guidance 209, published in 2012, specifically states two voluntary principles: "The use of medically important antimicrobial drugs in food-producing animals should be limited to uses that are considered necessary for assuring animal health and the use of medically important antimicrobial drugs in food-producing animals should include veterinary oversight or consultation." Guidance 213 was more specific to the elimination of antibiotics used in animal feeds. It provides the procedures for voluntarily phasing out growth promotion indications and establishing therapeutic treatment indications for the use of medically important antimicrobial drugs in food-producing animals.
Similar consumer pressures across the puddle during the mid-1990s forced the European Union to call for a phasing out of antibiotics used in livestock for growth promotion. Denmark was the first country, issuing a voluntary ban in 1998 which became compulsory in 2000. The result was an increase in death and disease among livestock and the greater use of antibiotics to control and treat disease. A paper published in 2009 by The American Farmers for the Advancement and Conservation of Technology states: "Although the overall use of antibiotics is still down somewhat … Total use declined by 30 percent between 1997 and 2005… quantities used for therapeutic purposes increased by 135 percent between 1996 and 2005." On top of this, there was "little evidence to suggest that antibiotic resistance in humans has declined, which was the purpose of the ban,"
Writing in The Journal of Applied Poultry Research, poultry veterinarian Hector Cervantes explains: "There is little convincing scientific evidence that the use of antibiotics in food-producing animals is contributing to the antibiotic resistance issues that are relevant to human medicine. However, public perception in first world countries suggests that consumers believe this to be true. According to the U.S. Organic Trade Association, sales of antibiotic-free (ABF) organic foods have grown at a rate of 20 percent per year since 1990. This is in spite of wider recognition that antibiotic resistance in humans is caused by antibiotic use in humans and not in food-producing animals."
Raising healthy livestock, given the ever-increasing demand for high-quality, value-priced meat without the use of antimicrobials is a challenge. Farmers, faced with the juxtaposed demands of quality and affordability, will have to continue to practice judicious use of antimicrobials to treat or prevent diseases in order to maintain a healthy population of animals while following the FDA's recommended withdrawal times to prevent antibiotic residues.
What would be helpful to the debate would be for meat producers to publically admit this and assure consumers that they have nothing to worry about.
Greg Rummo is CEO of New Chemic Inc., a company that imports various animal health products. This article is an adaptation of a longer paper including original market research.

domain: food


text:
Incorporating a industrial geothermal heat pump into a big building is becoming an increasingly common selection, and it is straightforward to see why. Geothermal heat pumps are eco friendly , they offer a comfy, dependable heat and the financial advantages imply your building will have low operating charges for decades.
Immediately after it leaves the constructing, the water is pumped back into the identical aquifer by way of a second well-named a discharge nicely-located at a suitable distance from the very first. Regional environmental officials need to be consulted whenever an open loop program is being deemed. Meacham Heating, Cooling & Power Options is undertaking its component to recycle all metal, oil, refrigerant, cardboard and paper.
The GeoColumn heat exchanger systems are also a plug-n-play” technologies as the only drilling needed done by a medium duty caisson-kind earth-auger or digger-derrick drill and the only personnel needed to finalize the installation being your neighborhood, friendly neighborhood-primarily based HVAC dealer/installer. The most frequent horizontal heat exchanger style is two pipes placed side-by-side in the same trench. Yet another heat exchanger often utilized where area is limited is a spiral” – which describes its shape. Other horizontal loop designs use four or six pipes in every trench, if land location is limited.
The Company’s founders have been active in improvement of direct exchange geothermal HVAC technology as well as its manufacture and distribution because 1993. These evolving approaches have been primarily aimed at maximizing method efficiency at minimal space and installation expense, and they established a sensible basis for the way horizontally-excavated GHEX design and installation is approached to this day-with a wide range of variations.
Heat pumps save income. Heat pumps are much more affordable to run than direct electric heating. They are less expensive to run than oil boilers and can be less expensive than operating gas boilers. Since heat pumps can be completely automated they demand considerably significantly less work than biomass boilers. EESs require small upkeep on your component. Required maintenance should be carried out by a competent service contractor, who really should inspect your unit after a year.

domain: design


Milvus Robotics announced today that it has executed the required agreement to participate in Ericsson Enterprise partner program.
SEIT-UV autonomous disinfection robot delivers a targeted dose of UV-C and can kill approximately 99.99% of viruses and bacteria within ten minutes – the perfect cleaning option for common use indoor facilities. Unlike conventional disinfection methods and approaches using chemicals, UV disinfection is more cost-efficient and effective.
Watch this video of the new Milvus SEIT UV robot as it goes through its disinfection paces.
Turkey based MIlvus Robotics is applying the technological potential of autonomy, mobile robots and artificial intelligence across industries to improve production, operations and time to market.
We review all of the current autonomous mobile robot solutions which are helping responders to manage the COVID-19 pandemic.