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“Can I give you some feedback?”
I don’t know about you, but rarely is this the prelude to my favourite kind of conversation.
For six little words, they sure can generate a lot of energy, both for the giver and for the receiver.
I think there are probably a lot of reasons for this, none the least of which is that giving and receiving feedback requires vulnerability on both sides. Vulnerability tends to trigger our fears and their ensuing self-preserving defenses. From there, it can often be a free-for-all of disagreeing, judging, defending and saving face.
All this because we wanted to make something better.
So, what happens instead? Why does getting and giving feedback so often suck? Why does feedback make us feel so wary?
I recently had a conversation with someone who had been asked to provide feedback to an organization she was part of, and she really didn’t want to do it. It made her feel vulnerable to offer her feedback, and she didn’t believe they would do anything with the feedback, anyway. She even worried it might be used against her in some way.
The more we teased apart what was in the way of her feeling empowered to provide feedback in this circumstance, the more we could see where some wires were getting crossed. The feedback she had for them was layered with her complaints, judgments and opinions about what was wrong and how it should be fixed. She was already frustrated at the thought they wouldn’t do exactly what she wanted them to do about it, so why even bother giving feedback at all?
I think this is pretty familiar for all of us, myself included, when it comes to the minefield that is feedback.
The key here, I think, is that when we give feedback, it ought to be about the giving of it. To give something means we freely transfer the possession of something over to someone else. Giving means it’s a gift, a thing given willingly without the expectation of compensation in return.
Let’s be honest, though, how often do we really treat feedback like a gift, whether we’re giving or receiving it? I know I often don’t. Instead, I’ll admit I’m attached to being right, regardless of which side of the conversation I’m coming from. I often feel righteous, offensive and judgmental in the giving of feedback, and I often feel protective, defensive and judgmental in the receiving of it.
I figure this all makes sense. We make anyone’s less-than-absolute satisfaction in who we are and what we do mean that we aren’t good enough. This, in turn, triggers old childhood wounds and stories about who we are or who we are not, which, along with our evolutionary biological drive to fit in, threaten our ability to stay loved, safe and sound in our village. After all, there’s safety in numbers, you know.
Whoa. So all that’s what’s going on when we’re in a feedback conversation. No wonder we get all funky about it.
Maybe, though, it can go differently. Maybe we can shift how feedback tends to go by shifting how we think about it.
To begin with, we need to recognize that if we’re giving feedback, then we’re giving a gift. That means we give our feedback freely, without expectation of anything in return, or that the other side do anything in particular with it. After all, a gift with strings attached isn’t much of a gift: it’s an obligation.
We can practice relinquishing our expectations by recognizing that we have them in the first place, and identifying our attachment to a particular outcome. Because, let’s face it: we all have have attachments to particular outcomes, and what we think everyone else should be doing.
The reality is that we don’t really have any control over the outcome of our feedback (or, you know, other people) anyway. Pretending otherwise just leaves us feeling frustrated and powerless when someone doesn’t do what we want them to do with our feedback, which, after we’ve given it, is mostly their business and none of ours.
From there, it’s important to examine the feedback we’re giving and receiving: is it actually feedback? That might seem like an obvious question, but it’s worth noting that the definition of feedback is literally just “information about a reaction to a product , service or experience”. Nothing in that definition includes “judgments, opinions and advice”, even though that’s often what we’re serving up, isn’t it?
So then, if we’re being honest, are we really just giving information about our experience, or are we handing over our judgments, opinions and advice about what we’d have preferred? I, for one, can own that often, I’m pretty righteous about my feedback, including how others should change to be better, according to me.
What if it’s possible to provide feedback that isn’t judgment or advice disguised as helpful information? What if we could discern what’s helpful and what isn’t from feedback we receive, instead of reacting to the parts we didn’t like? What would it be like to give or receive that feedback?
After all, unless someone’s asked us explicitly for our judgment, opinion or advice, then that’s not the kind of feedback they’re looking for. If it feels important to share our opinions and advice, then by all means, we could always tell them that we have an opinion or some advice and ask if they’re open to receiving that, too.
The best part about this approach is that it lets feedback be a true gift. It lets us off the hook of feeling frustrated with how our feedback is received, and it also means that we’re free to accept feedback without feeling like we’re on the hook for what we should do with it.
How do you feel about feedback? What do you make it mean, about you, about them?
What would be possible if feedback was just information and you were free to heed it or ignore it, regardless of anyone’s expectations, including your own?


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Not a stranger to the dutch scene he’s now slowly getting the recognition he deserves after working hard for many years which is starting to pay off. After having explored many styles it’s become clear that Muzikjunki has found what he’s looking for. His unique style blends House, hip hop, electro and a touch of progressive all into one infectious style of dirty beats and gritty bass lines. Joining forces with heavyweight Peter Gelderblom resulted in a single on Spinnin’ records ( Peter Gelderblom & Muzikjunki – Trapped ) a remake of the 1986 Colonel Abrahams classic which is signed to20+ countries sofar and appears on several trendsetting compilations like Hed Kandi, 538 Dancesmash 2008 part 1, Slam FM’s Grandslam compilation. Furthermore he’s working on new originals and remixes for a.o. Spinnin’, Boom Tsjak, Stealth, Ministry of Sound, Cr2, Nervous, Little Mountain and Wazzup!.
While playing for major brands like Ministry of Sound & Pacha and holding residencies for the ‘Feel the house’ events in Moscow’s Arma 09 club and Sander Kleinenberg’s This is… and Little Mountain rocks events all over the world, Muzikjunki’s DJ schedule for 2009 already contains dates in : UK, Russia, Germany, Spain, Ibiza, Dubai, Holland, Greece and France. Muzikjunki played alongside Underworld, the Chemical Brothers, Neneh Cherry, Ferry Corsten, Erick E, Sander Kleinenberg, Fedde le Grand, Marco V, Laidback Luke, Funkerman, Don Diablo, Pablo Ceballos & many more. Although his full schedule of dj gigs doesn’t allow him to spend more time in the studio there will be a Muzikjunki release every month in 2009….
Keep an eye out for this original Muzikjunki, bigger things are on his way and nothing is stopping him now!
It’s the music that makes the Junki……
Edited by noomka on 26 Sep 2009, 15:39
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domain: artistic


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Today we are going to be discussing about those signs that will make you understand that your laying birds or egg laying chickens popularly referred to as layers are old or tired of laying eggs for you and what you need to do at that period as a poultry farmer.
First let us understand what breed of chickens are referred to as layers or laying birds and how you can identify them when they are still young (young birds, Day old chicks, pullets). Pullets are young female chickens that are not sexually mature and less than 4 months old or but more than 2 months old. Layers or hens are sexually matured chickens that are ready to lay eggs. Point-of-lays could also be called hens or layers since they are sexually matured.
When you procure your chicks from a hatchery, there are possibilities that both males and females. If you want to tell the difference between a cockerel and pullet, there are a few things you can look for in determining if a chicken is a male (cockerel) or female (pullet) and they include but not limited to the following:
1. Wattles and Combs
Cockerels have larger and more developed combs and wattles than pullets. These combs and wattles of cockerels turn red sooner than the wattles and combs of pullets. Also, the combs of pullets flop over while the combs of cockerels stand upright.
2. Body and Legs
The body of a cockerel is bigger than that of a pullet. A cockerel also has thicker legs while those of a pullet are quite small. When both are of the same age and body size, the legs of the cockerel are much larger than the legs of the pullet.
A cockerel has hackle feathers (pointed feathers on his neck) while a pullet has rounded feathers on her neck. Saddle feathers (pointed feathers on the back) are present on the back of cockerels and they also have sickle fathers (curved tail feathers). Pullets have straight feathers on their tails and other feathers on their body have rounded ends.
4. Plumage Color
The feathers of cockerels are brightly colored and have more iridescence and color variety to their than those of pullets.
Layer poultry farming means raising egg laying poultry birds for the purpose of commercial egg production. Layer chickens are such a special species of hens, which need to be raised from when they are one day old up untill they start laying eggs and should be sold as meat when their egg laying cycle completes. They can produce about one kg of eggs by consuming about 2.25 kg of food during their egg laying period.
In one sentence, Chickens raised for eggs are known as layers, while chickens raised for meat are called broilers or cockerels. Their feed formulation,feeding methods, and feeding patterns largely depends on the time of chickens you are raising aand the purpose of production whether you are raising them for egg production or meat alone.
You can check out our feed formulas for the type of chicken you are raising inorder to produce your own feeds for your birds: Chicks Mash Feed Formula, Growers Mash Feed Formula, Layers Mash Feed Formula, Broiler Starter Feed Mash Formula (Female Broilers), Broiler Starter Mash Feed Formula (Male Broilers).
Spent layers or Old layers are egg laying birds that are past their prime, whose output is increasingly irregular, rendering them economically inefficient.
As the Poultry Farmer, once your Laying birds or Layers chicken start showing you the following signs below, you just have to know that they are Old Layers or Spent Layers or maybe they are tired of laying eggs and at that point you just have to sell them off as they are no longer economical to raise for profit.
Some of the signs include:
(1) Laying fewer eggs than usual
(2) Their feathers starts dropping (Excess feathers pulling from their body)
(3) The cost of feed and inputs remains the same but their earning capacity is greatly reduced.
Here is our Youtube Video on some of the signs, You are also encouraged to please kindly subscribe to our youtube channel for more amazing informations as well as also share the link with your loved ones. Thank you
Meanwhile there are certain factors that affects the performance of egg production which if properly managed can lead to high profits and return on investment for the poultry farmer. Some of those factors are discussed below.
Factors that Affect Egg Production of Poultry
There are about eight (8) major factors that directly or in directly affects the egg production rate. The factors like aging, feed consumption, water, intensity and duration of light, diseases etc affects the production of eggs.
(1) Aging hens
Just like we are still discussing about old layers or spent layers, Aging is a big problem in egg production. A hen can live many years and it lays eggs continuously for these years. But after a sudden period of time like 2 or 3 years it’s egg production rate significantly reduces.
It actually depends on the quality of hens that you are raising. Good layer hens lay eggs continuously for about 50 to 60 weeks then it takes a break. This time period is called molt. Poor and older layers more often molt and lay eggs less continuously.
(2) Improper Nutrition
Chickens need a balanced diet with enough level of protein and calcium to continue the maximum egg production over a certain period of time. Improper nutrition can make the hens to stop laying eggs. Imbalanced level of protein, energy and calcium can drop the egg production.
That’s why it is so important to supply a continuous balanced food to get a continuous supply of eggs.
Imbalanced food can cause many problems like oviductal prolapse. It mainly occurs when the birds are too fat or the egg size is too large. Prolapse can cause permanent damage to the hens.
(3) Rejecting important food ingredients
Another important factor that makes you hens to lay eggs occasionally is the subtraction of important food ingredients.
Every animal needs salt. If you subtract salt from the food list it will reduce the egg production rate. Most of the animal’s food contains salt in the form of sodium chloride. It doesn’t contain any iodine.
Sodium is an important nutrient which plays an important role in maintaining the body fluid volume, proper osmotic relation and blood ph. Chlorine is also an important ingredient. HCl which release from stomach helps to digest food. Chlorine also maintains the osmotic balance in body fluid.
The egg shell of hens is mainly composed of calcium carbonate. New hens need relatively a low amount of calcium at their growing period but when it start to lay eggs, it needs more calcium about four times relative to previous days.
Inadequate calcium supply will lead to reduce egg production rate. Calcium can be supplied with the food. Limestone is a great source of calcium. You can mix it with the food you supply to your hens.
(6) Vitamin D
Vitamin D is needed for the absorption of calcium. If improper vitamin D is supplied with the food ingredient it will result in decreased egg production. Feed contains vitamin D in two forms D3 and D2. In birds D3 is more active than D2. So you have to supply vitamin D only in the form of D3.
The requirement of protein is actually the requirement of amino acid which constitute the protein. There are about 22 types of amino acid in body protein and all of them are essential. Hens can’t produce all of them and also can’t produce enough to meet their requirement. So poultry farmers need to supply extra protein with the supplied food. The requirement of amino acid depends on the age, type and strain.
(8) Management mistakes
Improper management system can also reduce egg production. Some mistakes that the farmers often does are:
Out of food is one of them. If you keep your hens out of food it will reduce its egg production. The reduction of egg production depends on the time without food. Make sure that your birds have enough supply of foods.
Water is also an essential element. Water represents about 70% of body weight. Inadequate water supply can also reduce egg production. Birds are more sensitive to water than food.
Daylight is also a great factor which controls the production of eggs. Hens need at least 14 hours of daylight. The intensity of light must be sufficient to increase egg production.

domain: biology


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16th May, 2011
Former governor of Ogun State, Aremo Segun Osoba, has vowed never to have anything to do with former president, Olusegun Obasanjo. He also said he would never have a hand shake with the Ota farmer.
Osoba, who spoke during an interview published in the current edition of TheNEWS magazine however said if he happened to meet outgoing governor Gbenga Daniel, he would shake hands with him because the embattled governor â€œis down and outâ€ and should not be kicked further.
According to the Action Congress of Nigeria stalwart, he was not thrilled by the partyâ€™s victory against Obasanjo, because God had answered his prayers that all those who committed perfidy against the Yoruba people would be answered at the appripriate time.
Osoba said he had only met Obasanjo once since 2003 when the latter betrayed the Yoruba people.
â€œThe only occasion where we met was at the church service for the late Justice Ejiwunmi of the Supreme Court and he got the judgement of the people on that day too.
â€œThe ovation that we – Governor Fashola, myself and others – got when we were introduced reverberated round Lagos Island, but there was dead silence when Obasanjoâ€™s name was mentioned. That was the only occasion where we met,â€ he said.
When asked if he would shake hands with Obasanjo if they both met by chance, Osoba said: â€œGod forbid! I will not shake hands with Obasanjo because he wonâ€™t shake hands with me. If he pops his hands out, I will behave the way he will behave by not shaking his hand.â€
Osoba said with the ACN taking over the south western part of the country, the development of the region would become easier.
He said the party had met with the governors-elect and has asked them to create a blue-print for the development of the entire south-west.
He also said the Lagos Ogun Mega City Development Authority which he started with former governor of Lagos, Bola Tinubu, but which was stopped by governor Daniel would be revived.
On how the party lost the south-West in the presidential election, Osoba said the ACN actually lost control of the electorate at that stage as they decided to vote for President Goodluck Jonathan for reasons other than his competence and capability.
â€œSince President Jonathan went to the Redemption camp to kneel before Pastor Adeboye, there were ripples in the Christian community, which became a problem for us to control. We lost our votes for that singular event,â€ he said.

domain: politics


text:
Ben wrote:I think construction is starting anytime now. Builder has been appointed.
15-storey vision for Light Square
Business23 Mar 12 @ 09:45am
A new $75 million apartment block will be built in Light Square.
The 15-storey building, called Vision on Morphett, will comprise 157 apartments with ground floor retail.
Work will start in May, with the project due to be completed by the end of next year.
Developer the China-Australia Property Development Group expects the project will create 160 construction jobs.
The building will offer one, two and three-bedroom apartments starting from $189,000.

domain: news


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Content Warning: Sexual assault, sexual abuse of a child, PTSD, anxiety, depression, ADHD, bipolar disorder, dissociation, trauma
I want to preface this all by emphasizing that even though every day is a struggle and life is exhausting, taking things as they come is the key to making it through. Let’s be honest, there are so many things that need to be done, but that doesn’t mean I have to like doing it. Sometimes it’s easier to do things and be mad about it because at least it gets done, right? Anyways, let’s jump in.
I have a long list of diagnoses including PTSD, generalized anxiety, depression, and ADHD, as well as a family history of bipolar disorder. I also have Hashimoto’s thyroiditis, which only adds to depression and anxiety because of the hormone fluctuations.
Dealing with ADHD and PTSD at the same time is a wild ride. I am constantly fighting to not dissociate the day away, and when that works, I do the wrong tasks and get nothing done because the time flew by unexpectedly. I feel like I am not taken seriously a lot of the time because “everyone has ADHD nowadays” and “it seems like having mental health issues is something people use to be quirky” as if I chose to feel this way.
It’s hard to put into words the things I think and feel because I never learned how to “feel my feelings” and there’s way too much going on in my head. I’m scatterbrained and unmotivated, but if I manage to put myself on autopilot, I can get stuff done and declutter my brain for a while. The only problem with that is I won’t remember doing the stuff and if anyone has a conversation with me about something while I’m in the middle of a task, I won’t remember what they said. Bottom line, try to stay out of autopilot if you can and know the signs of a dissociative episode. Easier said than done, I know.
I don’t remember the last time I really felt at peace or content. I was sexually abused at around 10, but didn’t tell anyone until I was 20, because I figured I could forget about it and life would move on. I was successful for a while, but in the meantime, I was helping one of my best friends with her mental health. It was hard to see my friend struggling, and it was very easy for me to tell myself that I could have it worse, so there’s no reason to ask for help. When I got diagnosed with hypothyroidism (Hashimoto thyroiditis), I figured my depression was just a symptom of that and told myself I was cured when I started taking medication. My house burned down about a year later, and this is when autopilot came in. When I say “autopilot” what I mean is putting myself in a box in the corner of my brain, so I can shift my focus on doing things that I feel are more important. It’s hard to explain. The man that abused me ended up moving in next door, so my anxiety spiked and after a few years I finally caved and told my parents. Shortly after that, my friend group/roommates kicked me out of the apartment and even though I had my partner of now 9 years, I felt completely alone. It’s been a few years now since that happened, and I’m proud of myself for making it through. It really is amazing how much people can withstand.
To anyone else who’s dealing with the same issues, if I knew you, I would make sure you understood that I am incredibly proud of you just for making it through the day. Thank you for reading, and I hope this is helpful.

domain: psychology


CES 2021 | Dell updates Latitude 7420/7320 & expands the business premium-class with 15.6 inch Dell Latitude 7520
In the past, Dell Latitude laptops of the series 7000 were the creme de la creme of Dell's enterprise portfolio. At this point though, the Latitude 9000 series has assumed that function.
The new models Dell Latitude 7320 and Dell Latitude 7420 and their respective convertible variants are still premium laptops. And their importance in the Dell universe is not decreasing. On the contrary, as Dell is expanding the series with the new Latitude 7520. For the first time, business customers get the option to order the Latitude 7000 series with a 15.6 inch screen.
Dell Latitude 7520: Latitude 7000 now with a big screen
Til now, there was an open spot in Dell's lineup. Between the mid-range Latitude 5510 and the expensive Dell Precision 5550, there was no enterprise model in the 15 inch size. While Lenovo does not make a ThinkPad T15s and there is currently now EliteBook 1050 from HP, the Lenovo ThinkPad T15 and HP EliteBook 855 were still more up-market models than the Latitude 5000. This hole is now filled by the new Dell Latitude 7520.
Latitude 7000 2021: low power screens with higher brightness, but smaller batteries
The new models of the Latitude 7000 series look a lot like their 2020 predecessors, but they are still redesigns. The updates are not as big as the new Dell Latitude 5x20, but there are some parallel developments. The maximum battery capacity decreases here as well, going down from 68 to 63 Wh. For that trade-off, the new models are slightly thinner, lighter and more compact than their predecessors.
Of course, the new Latitude 7320, Latitude 7420 and Latitude 7520 contain Intel Tiger Lake processors. These CPUs are combined with up to 32 GB on-board memory. There are no dedicated GPUs and Dell did not announce any AMD Ryzen versions, either.
Like for the less expensive Latitude 5000, Dell will offer brighter screens in the new Latitude 7000 laptops. The optional low power LCDs now deliver 400 instead of 300 cd/m². It should be noted though that the screens are still in the 16:9 aspect-ratio. The 16:10 format stays exclusive for the Dell Latitude 9420 for the time being.
Dell Latitude 7000: pricing & availability
The new Dell laptops are supposed to be available in March. Dell did not disclose a starting price at this point.


text:
Before there were kings, there was a spider – life and death intertwine in Ududeagu, the intimate and mystery...
Before there were kings, there was a spider: language and body as habitat in a dark and mystery mutant experiment
Nigeria / 2minutes
The Rise Of The Fashion Short
Fashion Film has just recently found a definition as a genre, but the mutual influence between fashion and cinema...
From Wes Anderson to Spike Jonze, many directors are experimenting with the Fashion Film, a newborn genre in which everything is possible.
Online Premiere: Thriller
With the city of Taranto bent by pollution and uncertainty for the future in the background, Michael, 14, goes around...
Michele dreams to dance in TV like his idol Michael Jackson, but the protest in which his father is involved threatens his dream.
Italian / 14minutes
A distant land where the entire social system is based on the power of the wind. Strong and relentless,...
The everyday activities of the inhabitants of an extremely windy area are hard. But what if the wind stopped blowing?
(HAW Hamburg Department Design)
Germany / 4minutes
Code 8 – by Jeff Chan
In the last few years short film has been act as a springboard for a lot of young directors,...
Reality and fiction are melting in Code 8, your next sci-fi cult.
USA / 10minutes
Ouro – by Pierre-Jean Le Moël & Eva Jiahui Gao
Ouro is an animated short film directed by Pierre-Jean Le Moël and Eva Jiahui Gao, who are both in Masters Degree programs at...
A fairytale in action about vengeance, Ouroboros, and the power of women
Francia / 4minutes
Are we still able to approach a person without the use of internet? This is the question British director Samuel...
A 'single' guy challenges himself to find a his next date without the help of the internet.
(Joshua Smith & Samuel Abrahams )
UK / 6minutes
Don’t Forget My Words – by Riccardo Rabacchi
The short film by the Italian director Riccardo Rabacchi carries strong echoes of a Woody Allen’s movie. This comparison...
A young man with confused ideas finds himself in a weird theatre of the absurd
(Image Hunters, Dispàrte, Tropico del Libro)
Italia / 7minutes
OPEN CALL: WE ARE LOOKING FOR CONTRIBUTORS!
Join our team! Write about the best short films from around the world, help us finding the next filmmaking...
Crowfunding: Candice by George Watson
George Watson is an award winning director who began his career in documentaries before switching into fiction. He was...
Turn the Slate Productions has launched a Kickstarter campaign for the new short by 'Twelve' director
A man cries while listening an old tape, we hear the voice of a woman talking about how she...
War, time travel and a broken walkman are the backdrop to this science-fiction love story
USA / 11minutes
The Board – by David Shane
Evan is a socially awkward teenager, who constantly finds himself at a loss for appropriately cool words during his...
Practical tips from a teenager busy with the opposite sex
USA / 13minutes
Sequence – by Carles Torrens
The common saying “the man or woman of your dreams” is mostly referred to an unreachable ideal, which is...
Daydreaming could be so dangerous...
Spain / 20minutes
The Christmas Light Killer
Every night in December people in a small suburb of Philadelphia flock to a holiday light show. They drive...
A man spends his December nights shutting down the power for a huge holiday light show. What is his point?
USA / 6minutes
Cutaway is a very simple short build on “visual deprivation”. We follow a man working hard, doing his best to support a pregnant woman,...
Through close up details of hands, we follow the life of a single young man as he works, pursues relationships, and comes to terms with a life changing event.
(Medium Density Fibreboard Films)
Canada / 6minutes
Wanderers is a short science fiction film created by Swedish digital artist Erik Wernquist which offers a glimpse of the...
A spectacular and scientifically based (pre)vision of humanity's expansion into the Solar System, commented by Carl Sagan's original voice.
(Self produced )
Sweden / 4minutes
Head over Heels
After many years of marriage, Walter and Madge have grown distant from each other, to the point that they...
This Oscar-nominated animation is an heartwarming tale of a married couple whose lives have grown in opposite directions.
UK / 10minutes
The Six Dollar Fifty Man
Suburban Neo Zealand, 1970s. Smalltown life ain’t easy for those who are different, especially during childhood. Andy is a...
A festival favorite, this dramedy shows how hard it is to be a "superhero" in a suburban school in the 70s.
Neo Zealand / 15minutes
The surreal animations of Jan Švankmajer
When The Guardian asked Terry Gilliam to pick his ten favorite animated films, the director included “Dimensions of Dialogue“,...
As the Milano Film Festival hosts a retrospective on Jan Švankmajer, we take a look at the career of the great Czech director and animator.
Does the Italian film system neglect short films and its emerging talents?
In our latest article on the Italian Huffington Post we discussed a rather alarming fact: the very low presence and...
Our interview with Jacopo Chessa, the director of the Italian National Center for Short Films.
Soar – by Alyce Tzue
Soar is the story of a young girl Mara who dreams of one day building airplanes. She builds these...
A young girl must help a tiny boy pilot fly home before it's too late.
(Student Film (Anson Yu))
USA / 7minutes
Dr. Easy was adapted from the first chapter of Red Men, a dystopian novel by Matthew De Abaitua. The...
A robot with medical training is sent to negotiate a dangerous situation.
UK / 9minutes
Some feelings are universal. The apprehensive await for a the mailman and the important letter he’s bringing. Evgeniy’s passion since...
An innovative thriller starring Kevin Spacey, set in the Russia's Cold War era.
(Trigger Street Productions)
Russia / 17minutes
Panorama – by Gianluca Abbate
Panorama, world premiered at the International Film Festival of Clermont-Ferrand Short Film 2014, is the animated short film directed by Gianluca...
A polis stretches away over an infinite global space with no more uninhabited places nor frontiers
Italy / 7minutes
Online Premiere: I Navigli
A “coxless pair” slips smoothly along the calm waters of the Navigli. It passes through the city of Milan heading south-west, to...
Life and feelings of two rowers training in the placid waters of the historic canals in Milan.
Italy / 6minutes

domain: entertainment


text:
East Farmingdale, NY- Public transportation on the East End of Suffolk County is evolving. On Wednesday Suffolk County Executive Steve Bellone, announced a new partnership with Hampton Jitney and Via, to launch a “first-of-its-kind mobility service”, which will allow passengers to book rides on demand. Suffolk Transit On-Demand, which launched earlier this month will provide five free rides per person through August 15, 2021.
Suffolk On-Demand is wheelchair accessible and will operate from 6:30am-8:30pm Monday through Friday. Rides cost $2.25, with discounts available for children, students, seniors and persons with disabilities. Passengers can book a ride on the Suffolk Transit On-Demand app or by calling 631-818-2982.
The app will offer in-app wellness checks to ensure passengers and drivers are symptom-free and ready to ride. Everyone on board will be required to wear a face mask or face covering. Vehicle capacity will be limited in accordance with social distancing guidelines, and vehicles will be professionally cleaned regularly.
Photo: Suffolk Transit On-Demand vehicle, courtesy of Suffolk County Executive Steve Bellone’s office


text:
Phil’s father was a college music professor and his mother a piano teacher and organist. With their encouragement, he began to improvise (bang?) on the piano from an early age. When it came time in fourth grade to sign up for an orchestra or band instrument in the public-school music program, he decided the trumpet would be fun. But his dad suggested there would be more opportunities for playing if he chose a stringed instrument, so Phil agreed to give the cello a try. Good advice, Dad!
Phil is still playing on the same instrument his parents bought him in 1963 around the time he began private lessons. He also now has a baroque cello which he uses as a member of the early music group St. Mary Schola. At the other end of the historical spectrum, he directs the Back Cove Contemporary Music Festival at the Portland Conservatory.
He has degrees in composition from the University of Washington, Brooklyn College, and CUNY. His music has been performed widely, including by the Portland Symphony Orchestra and the Sebago-Long Lake Region Chamber Music Festival. Retired in 2015 from the University of Maine at Farmington, where he taught music and conducted the college-community orchestra, Phil now lives in South Portland with his wife, the poet Jeri Theriault.


text:
Floyd Mayweather's The Journeyman
- Artist: Floyd Mayweather
- Written By: Jason M. Burns
- Art By: Dustin Evans
- Language: English
- Digital Release Date: April 19th, 2017
In an attempt to once again make boxing the most popular sport in the country, a seedy promoter driven by greed enhances athletes with superhuman strength and abilities and forces them to fight for sport. The series has been created in such a way that various artists will be represented in their own books, each with their own powers and abilities, and then ultimately converge into one finale that features them all as they take on the evil promoter.

domain: library


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Mantras, the sacred chants of India, offer us a way to illuminate our lives, heal, and open a space of peace and stillness within. In Chanting Mantras with Deva Premal & Miten, two luminaries of India's devotional music tradition invite us to awaken that energy with their first audio learning program. Every day for 21 days, you'll learn a traditional mantra. Deva and Miten explore the meaning of each mantra and its unique properties, including detailed instruction on how to engage and work with it.
In their second in-depth mantra meditation course, the celebrated musical duo shares a new collection of empowering traditional chants. To be enjoyed on their own or as a complement to the first volume, the focus here is practical and targeted, featuring mantras that they have found most relevant to common life challenges. Day by day, Deva Premal & Miten introduce us to a new mantra, clarify its meaning and purpose, guide us in preparatory meditations, and then lead us in an inspiring chant session.


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GSE is pleased to celebrate the recent achievements of the students and faculty in our Division of Psychological and Educational Services! We look forward to sharing many more exciting successes and accomplishments with you in Fall 2013.
Counseling Psychology doctoral student Aziza Platt was selected as a recipient of The Roothbert Fund, Inc. Scholarship and received an additional designation as a Bloom-Feshbach Fellow in honor of psychiatrist Jonathan Bloom-Feshback. She was also selected as a recipient of the 2013 J.W. Saxe Memorial Fund.
- H.B. Matos-Elefonte, Dr. John Houtz, Dr. Thanos Patelis, and E. Selby presented a poster entitled Problem-Solving Styles, Learning Behaviors and Attitudes, and Mathematics Performance.
- Dr. Akane Zusho presented a roundtable session entitled Achievement Goals in Context.
- Drs. Rhonda Bondie, Akane Zusho, Marshall George and S. Turco presented a poster entitled Making Differentiated Instruction Sustainable Through Online Self-Regulated Learning and Structured Choice.
Dr. Mitchell Rabinowitz will give the following presentations, including one with co-presenter and Educational Psychology alum Dr. Lindsay Blau Portnoy, at the upcoming Association for Psychological Science and European Association for Research and Learning conferences:
- Drs. Mitchell Rabinowitz and Lindsay Blau Portnoy will present a poster entitled What’s in a Domain: Understanding How Students Approach Questioning in History and Science at the 25th Annual Convention of the Association for Psychological Science to be held in Washington, DC in May 2013.
- Drs. Mitchell Rabinowitz and William B. Whitten will present a poster entitled Correspondence of Cognitive Events and Cognitive Processes in Guided Cognition Tasks at the 25th Annual Convention of the Association for Psychological Science held in Washington, DC in May 2013.
- Drs. Mitchell Rabinowitz and William B. Whitten will present a poster entitled Research to application: Using Frames to Create Guided Cognition Homework for Unsupervised Learning at the Annual Convention of the European Association for Research and Learning in Munich, Germany in August 2013.


Used Car Dealerships Buffalo Ny – One of the largest groups of car dealers in the country wants to make a breakthrough in the Buffalo Niagara region. Lithia Motors recently bought Ray Laks Honda at Orchard Park and Ray Laks Acura at Amherst. As an Oregon-based company, Lithia will face rooted local car sales groups.
Time will find out whether Lithia sets more than just a foothold in the Buffalo Niagara region, and how well the company’s tariffs are on domestic competition. Several other dealer groups based outside the city are trapped here. Some haven’t.
Used Car Dealerships Buffalo Ny
Lithia doesn’t rule out making more acquisitions here. “As long as something meets our criteria, we will be open-minded for more,” said Tom Dobry, chief marketing officer.
Some large dealer groups dominate many new cars in the region: West Herr, Northtown, Towne, Basil, and Transitowne. They cover the market with many brands, locations and advertisements, and they have grown through their own acquisitions.
Enter Lithia, who keeps Ray Laks’s name at the two dealers that were bought. There is no doubt the resources that Lithia can use – the company reported a profit of $ 245 million in 2017 – but the company still has to compete with established local players.
And if you want to expand the Buffalo Niagara area – where a stagnant population means the automotive market is not getting bigger – he has to do it by convincing existing traders to sell.
Frank Downing Jr., president of Towne Automotive, said the Buffalo Niagara area has shown affinity for village brands, in various businesses. When it comes to selling vehicles, the region “has a strong local dealer group that has developed strong employees and built a loyal owner base that is difficult to penetrate,” he said.
Local dealers are also active in the community, which makes an impact, said Downing. “When was the last time you went to a community event or a charity event and you didn’t see involvement from a local dealer?” he says.
Mega channel groups may also prefer markets in other countries where their return on investment and return on sales have historically been higher, Downing said. Other markets may grow in the population, compete with fewer per capita traders, and face fewer regulations, he said.
Zeigler Auto Group, which is privately owned and based in Michigan, bought Don Davis Honda at Amherst in 2013. While Zeigler has locations in Michigan, Indiana and Illinois, it never expanded the existence of Buffalo Niagara outside of one location, far from its base. Zeigler recently sold a Honda dealer to Northtown.
Meanwhile, Albany-based Lia Automotive Group continues to compete in the region, through its dealerships on Transit Road in Clarence, and Adams-based Fuccillo Automotive Group has three dealers on Grand Island.
Downing said it was too early to say what impact Lithia had on local car sales. But unlike AutoNation and Ziegler, “I believe Lithia is here to stay and they will develop quickly,” he said. “Lithia has been successful in the Northeast and they seem to have an appetite for growth in Buffalo.”
The seller of another publicly traded car, CarMax, plans to open a superstore in Amherst, but has not announced the opening date. His business focuses on selling used vehicles.
Lithia’s arrival reminded a group of publicly traded sellers who had come to the Buffalo Niagara market more than two decades ago. In 1997, the Florida-based company known as AutoNation bought Al Maroone Ford in Clarence, as part of a larger agreement. The company left the area in 2006 when it sold dealers to Dave Smith Ford.
Dobry said Lithia likes middle markets like Buffalo, and said Honda and Acura tend not to overdealer certain markets.
“Pie is big enough for everyone,” he said. “We really emphasize and value customer retention. We don’t have to win so many businesses like taking care of customers who are there.” (There are a total of four Honda dealers in the region, and one Acura dealer.)
When Lithia considers purchasing a dealer, the company looks for a good store with a good brand, location and team, and the right price for investment, Dobry said. The shop must also have several opportunities “upward”, he said.
“If it’s a shop that does very well, then it’s not a good investment,” he said. “We didn’t buy it for that purpose. We bought it to improve performance.”
It’s just that, don’t look for Lithia’s name which is scattered on the local dealer signs. Litia continued to use the name Ray Laks, a practice that had been followed in other cities where he had obtained a location.
“We really want to maintain the local brand identity that these families have set,” Dobry said.
Despite its mammoth size, Lithia is not trying to micromanage the operations of myriad dealers from Oregon, Dobry said.
“We empower general managers who lead our stores [with] full autonomy to make all their decisions locally. We are a very decentralized company.”
The dealer made his own decision about recruitment and how many vehicles were ordered, he said. Lithia also likes to maintain a team of permanent employees who work in the location purchased.
But operations such as dealer Ray Laks can leverage resources, advice, and potential cost savings from large owners such as Lithia, Dobry said. Lithia may provide guidance on selling more used cars, expanding dealer financing options, or allowing employees to enter lower healthcare costs, he said. The company can also provide technology behind the scenes to make dealer business operations run more smoothly, he said.
“There are clear benefits and benefits that we will bring to them,” Dobry said.
The Litia car sales empire began modestly, with a Walt DeBoer dealer opened in 1946 in Oregon. The company continued to grow and go public in 1996. Grandson DeBoer Bryan became CEO in 2012, and he has encouraged an acquisition party. During 2017, Lithia bought 15 stores and opened a store, predicting the addition will generate more than $ 1.5 billion per year in additional revenue.
Last year, Automotive News’s Lithia ranking ranked No. 4 among the largest dealer groups in the country, based on 145,772 new retail vehicles it sold at 154 dealers in 2016. That rate was nearly 400 per day.
Lithia’s complete financial picture is even greater. Joint revenues from all departments – including vehicles sold, finance and insurance, workshops, parts and services – were $ 8.7 billion in 2016, according to Automotive News.
Local West Herr is No. 22 on the Automotive News list, with 29,486 new retail vehicles sold, and $ 1.8 billion in overall revenue.
As a public company, Lithia discloses its financial results every three months and is responsible to shareholders. Lithia recorded revenue of $ 10.1 billion in 2017, up 16.2 percent from the previous year. Lithia projects that two Ray Laks dealers will add $ 140 million in annual revenue to the company. For 2018, the Lithia project will generate revenues of $ 11 billion to $ 11.5 billion.
Lithia now has 171 stores representing 30 brands in 18 states. In the latest edition of the Fortune 500, which ranks US-based companies with annual income, Lithia is No. 318, one place behind Expedia and one place in front of Avis Budget.
Operating as a public company is “a source of capital,” Dobry said. “It continues like that, but the existing shop also produces that.”
And because Lithia is publicly traded, Litia’s dealer employees can buy shares and “feel like they have direct benefits from the company’s success,” Dobry said. He feels that opportunities help attract good managers and retain employees.
The company has developed into other Eastern markets, including acquisitions in northern New York. Lithia bought Armory Garage at Albany and the Utica-based Carbone Auto Group. Through the Carbone agreement, Lithia became aware of the opportunities at the west end of the country, culminating in an agreement with Ray Laks, said Dobry.
Is there more to come?
“Now we see the type of filling in some markets that we don’t enter,” he said. “That doesn’t mean Buffalo is more important than Kansas City. It’s just a question of when the right opportunities are available in those markets.”
Pictures gallery of Used Car Dealerships Buffalo Ny, Auto sales giant Lithia Motors gains foothold in WNY
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Are you looking for something homey, sweety, and cosy?
This recipe for croissants with berries is just what you need.
These enchanting croissants are the perfect idea to serve your family on a chilly fall evening.
Soft and tender, they are stuffed with succulent guelder rose berries and flavorful lemon zest.
Such a wonderful combination of ingredients makes these croissants so delicious that they just melt in a mouth.
Don’t miss your chance to try these croissants.
They are really worth it!
- 1 egg
- 1/3 tsp salt
- 4 tbsp sugar
- 300 ml milk
- 460 g (1 lb) flour
- a pinch of vanilla
- 20 g (2 tbsp) yeast
- 5,5 tbsp dairy butter
- 1/4 cup of sugar
- 2 tsp lemon peel
- 250 g (1/2 lb) guelder rose berries
Preheat milk and dissolve yeast there. Add 1 tbsp of sugar, 2 tbsp of sifted flour. Stir everything to combine. Leave the mass for 20 minutes.
Whip an egg mixed with sugar. Sift the remaining flour and combine it with melted dairy butter, salt, remaining milk, predough and the sugar-egg mass.
Knead the dough, cover it with a napkin and leave for 1 hour. The dough should increase in volume.
Place rinsed guelder rose berries in a stewpan and preheat them over medium heat. Then add sugar and grated lemon peel. Cook the mass until it becomes thick, for 15 minutes.
Punch the dough and separate it into two parts. Roll the crusts with 2 mm thickness each. Cut them into triangles. Put the filling on a wider part of the triangle.
Wrap each triangle into a roll. Cover the baking tray with a parchment paper. Transfer the croissants there and leave them for 15 minutes. Bake the dessert in the preheated oven at 175°C (347°F) for 20 minutes. Top the croissants with powdered sugar before serving.
Enjoy your meal!
Do you have a favorite Ukrainian recipe for croissants with berries? If so, please let us know in the comments below or write us an e-mail.

domain: food


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Dakota Lewis is a family member from the United States. Scroll below to find out more about Dakota’s bio, net worth, family, dating, partner, wiki, and facts.
He was born on December 24, 2002 in Arizona. His given name is “Dakota”.
Date of Birth:
Place of Birth:
Dakota Lewis – Name Meaning:
The meaning of the first name Dakota is friendly companion & the last name Lewis means well-known fighter. The name is originating from the American.
Age and Birthday:
Dakota’s age is now 19 years old. He is still alive. His birthdate is on December 24 and the birthday was a Tuesday. He was born in 2002 and representing the Gen Z Generation.
Height, Weight, and Physical status:
Dakota Lewis’s real height information is not known.
Narcissus & Holly
He and his family moved from Arizona to California. His mother designs dresses and his father works in construction. He began dating Emilee Herron in late 2018. He previously dated a girl named Arianna Flowers.
No. of Children:
He attended VidCon 2016 with his sisters.
Film, Movie, and Tv Show:
* Movie appearance not found.
* No Award information found
Net Worth, Salary, and Earning:
The estimated net worth of Dakota Lewis is between $1 Million – $5 Million. His primary source of income is to work as a family member.

domain: celebrity


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“Forgotten Occupation: Life in the Syrian Golan after 50 Years of Israeli Occupation” is the title of a new book published this week by Al-Marsad, a Golan Heights based human rights organization.
A press release by Al-Marsad, the only human rights organization based in the occupied Golan Heights, tells the story of the native Syrian population who continue to suffer after 50 years of occupation by Israel.
“In ‘Forgotten Occupation: Life in the Syrian Golan after 50 Years of Israeli Occupation’, Al-Marsad gives a voice to the voiceless, with Syrians explaining in their own words how the occupation has affected their lives,” said the press release, according to WAFA.
Syrians in the occupied Syrian Golan have now been separated for more than half a century from friends and family in the rest of Syria. The book describes how Syrians have witnessed the forcible transfer and displacement of friends and family; the destruction of homes; the appropriation of land and the arrival of a foreign occupier. It shows how Syrians have been treated as second-class citizens in their own country, and how they have fought to maintain their dignity and sense of identity, despite 50 years of oppression, it added.
The book is divided into nine chapters, which describe different aspects of life under occupation, such as family separation, housing restrictions and the dangers of landmines. Each chapter consists of an interview with a Syrian, explaining how they have been affected by that particular issue, as well as a legal analysis by an international expert.
Search IMEMC: “Golan Heights”

domain: sociology


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This customized keychain is engraved with "I love you in every universe" on the front, and includes your names and a date on the back. Makes a great anniversary, birthday, or Valentine's Day gift for a husband or wife.
Comes in steel or gold-plated steel.
The engraved bar measures 2 inches x 1/2 inch. The keyring measures 1 inch.

domain: design


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April 20 (Reuters) - U.S. stock indexes opened flat on Friday, as strong earnings from industrials General Electric and Honeywell were offset by declines in technology stocks and oil price.
The Dow Jones Industrial Average fell 7.50 points, or 0.03 percent, at the open to 24,657.39. The S&P 500 opened lower by 0.57 points, or 0.02 percent, at 2,692.56. The Nasdaq Composite dropped 17.41 points, or 0.24 percent, to 7,220.64 at the opening bell. (Reporting by Sruthi Shankar in Bengaluru; Editing by Shounak Dasgupta)


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- Blood Sugar
- Clinical Studies
- Complementary Medicine
- Diabetes and Men
- Erectile Dysfunction
- Food and Nutrition
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Archive - 03 - 2010
March 30, 2010 (EurekAlert) - BIRMINGHAM, Ala. - The age-old maxim "Eat breakfast like a king, lunch like a prince and dinner like a pauper" may in fact be the best advice to follow to prevent metabolic syndrome, according to a new University of Alabama at Birmingham (UAB) study.Metabolic syndrome is characterized by abdominal obesity, high triglycerides, insulin resistance and other cardiovascular disease-risk factors.The study, published online March 30 in the International Journal of Obesity, examined the influence exerted by the type of foods and specific timing of intake on the development of metabolic syndrome characteristics in mice. The UAB research revealed that mice fed a meal higher in fat after waking had normal metabolic profiles. In contrast, mice that ate a more carbohydrate-rich diet in the morning and consumed a high-fat meal at the end of the day saw increased weight gain, adiposity, glucose intolerance and other markers of the metabolic syndrome."Studies have looked at the type and quantity of food intake, but nobody has undertaken the question of whether the timing of what you eat and when you eat it influences body weight, even though we know sleep and altered circadian rhythms influence body weight," said the study's lead author Molly Bray, Ph.D., professor of epidemiology in the UAB School of Public Health.Bray said the research team found that fat intake at the time of waking seems to turn on fat metabolism very efficiently and also turns on the animal's ability to respond to different types of food later in the day. When the animals were fed carbohydrates upon waking, carbohydrate metabolism was turned on and seemed to stay on even when the animal was eating different kinds of food later in the day."The first meal you have appears to program your metabolism for the rest of the day," said study senior author Martin Young, Ph.D., associate professor of medicine in the UAB Division of Cardiovascular Disease. "This study suggests that if you ate a carbohydrate-rich breakfast it would promote carbohydrate utilization throughout the rest of the day, whereas, if you have a fat-rich breakfast, you have metabolic plasticity to transfer your energy utilization between carbohydrate and fat."Bray and Young said the implications of this research are important for human dietary recommendations. Humans rarely eat a uniform diet throughout the day and need the ability to respond to alterations in diet quality. Adjusting dietary composition of a given meal is an important component in energy balance, and they said their findings suggest that recommendations for weight reduction and/or maintenance should include information about the timing of dietary intake plus the quality and quantity of intake."Humans eat a mixed diet, and our study, which we have repeated four times in animals, seems to show that if you really want to be able to efficiently respond to mixed meals across a day then a meal in higher fat content in the morning is a good thing," Bray said. "Another important component of our study is that, at the end of the day, the mice ate a low-caloric density meal, and we think that combination is key to the health benefits we've seen."Bray and Young said further research needs to test whether similar observations are made with different types of dietary fats and carbohydrates, and it needs to be tested in humans to see if the findings are similar between rodents and humans."We're also working on a study right now to determine if these feeding regimens adversely affect heart function," Young said.
March 30, 2010 (EurekAlert) - Eating foods containing flavonoids -- orange juice, in this case -- along with a high-fat, high-carbohydrate fast-food meal neutralizes the oxidative and inflammatory stress generated by the unhealthy food and helps prevent blood vessel damage, a new study by University at Buffalo endocrinologists shows.
Free radicals, or reactive oxygen species, are known to induce inflammation in blood vessel linings and contribute to the risk of heart attack and stroke. Study researchers say the potent preventative effect of orange juice likely is linked to its heavy load of the flavonoids naringenin and hesperidin, which are major antioxidants.
"Our data show, for the first time to our knowledge, that drinking orange juice with a meal high in fat and carbohydrates prevented the marked increases in reactive oxygen species and other inflammatory agents," says UB's Husam Ghanim, PhD, first author on the study.
"This did not happen when participants drank water or a sugary drink with the meal," he says. "These issues of inflammation following a meal are important because the resultant high glucose and high triglycerides are known to be related to the development of cardiovascular events."
Ghanim is a research assistant professor in UB's Division of Endocrinology, Diabetes and Metabolism. The study appears in the March issue of the American Journal of Clinical Nutrition and appeared online ahead of print.
The study involved three groups of 10 normal-weight healthy men and women between the ages of 20 and 40. After an overnight fast, participants ate a 900-calorie breakfast composed of an egg "muffin" sandwich, a sausage "muffin" sandwich and a serving of hash browns. The meal contained 81 grams of carbohydrates, 51 grams of fat and 32 grams protein.
Along with the breakfast, one group drank 300 calories of "not-from-concentrate" orange juice, a second group drank a 300-calorie glucose drink and the third group drank an equal amount of water. All participants were given 15 minutes to finish their food and drink. Blood samples were collected before the meal and at 1, 3 and 5 hours afterwards. There was no significant difference in inflammatory mediators among the groups before the meal.
Analysis of the samples after the meal showed that oxygen free radicals increased an average of 62 percent with water, 63 percent with the glucose and 47 percent with orange juice. There also was an increase in blood components known as toll-like receptors, which play an important role in the development of inflammation, atherosclerosis, obesity, insulin resistance, and injury to cardiac cells than can occur after a blocked vessel is reopened.
Orange juice also prevented a significant increase in SOCS-3, an important mediator of insulin resistance, which contributes to development of type 2 diabetes.
"These data emphasize that a high-fat, high-carbohydrate meal is profoundly and rapidly proinflammatory, and that this process occurs at the cellular and molecular level," says Paresh Dandona, MD, UB distinguished professor of medicine, director of the Diabetes-Endocrinology Center of Western New York at Kaleida Health and senior author on the study.
"In addition, specific proinflammatory genes are activated after the intake of glucose and a high-fat, high-carbohydrate meal, and these changes are observed in mononuclear cells that participate in vascular inflammation and insulin resistance," he says.
"These observations extend our previous work showing oxidative and inflammatory stress following such meals by demonstrating a remarkable increase in the mediators of insulin resistance after a single meal, and the equally remarkable prevention of these changes following the intake of orange juice."
Dandona emphasizes that vascular inflammation is an essential component of atherosclerosis, and that this inflammation may become permanent if a person consumes similar meals regularly.
"The choice of safe foods that are not proinflammatory may provide protection from the unending cycle of postprandial and cumulative inflammation," he says. "This choice may lower the risk of atherosclerosis and resistance to insulin."

domain: medical


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Dried Shiitake Mushroom. Product Type: Dried mushrooms. Part: whole, cut off the stem. Diameter: 3-4cm up. Type: shiitake. Moisture: 12%. Drying Process: AD. Shelf Life: 24 months. Place of Origin: Vietnam. Non impurity, non additives, non GMO. Packing: 500/1000g PA bag, then in 50kgs PP bag or carton, customized. 99 GOLD DATA
hiitake mushroom is the second nutrition mushroom in the world. Shiitake mushrooms are low in calories. They also offer many vitamins, minerals, and other health-promoting compounds. Dried shiitake mushroom can use for cooking or snack. Shiitake mushrooms are extremely versatile and can be added to soups, stews, salads, vegetable dishes, ragouts, meat dishes, omelets, and stir-fries. The flavor is typically described as woody or earthy, which limits their use in culinary applications but savory dishes can often benefit from the mushroomÃ¢??s hearty texture. Desscription - Name coffee wood dog chew - Origin: Viet ma, fr;ysp - Shippinh: ny sea move, - Payment T /T, L/C, Western Union
We introduce ourselves as stockiest and exporter of dried Mushrooms, in many forms as below mention :- 1- Dried Conica Morels Special- Head Size 2-5/6cm-Stem Clipped 2- Dried Conica Morels Extra - Head Size 2-5/6cm -Stem 1-2cm 3- Dried Morels MINI Special - Stem Clipped Head Size below 2cm 4- Dried Morel CONICA STEM - Sandbag Clipped 5- Dried VERPA Bohemica - Head Size 3cm - 6cm We will quote prices on your specific inquiry mentioning Quantity. Shipment : Minimum 250 Kgs OR Maximum 1000 Kgs per shipment Payment : By 60% Advance remaining 40% on cargo arrival. Your reply will be much appreciated.
EKOFUNGI is originally organic champignon producer, one of the very rare in Europe.We produce fresh, organic Champignon and Oyster mushrooms. Then we dehydrate them at temperature of 35 - 40 °C. This way nutritive value as well as the authentic taste is preserved.All our products are salt free, EU organically certified, suitable for vegans, all ages and health conditions. Shelf life of our products is up to 2 year, as an additional value for our customers and buyers, since it doesn't need temperature controlled shipment and handling. Rich in vitamins B and D, proteins, fibers. certification: EU and Swiss organic certification, HACCP Product type: Dried mushrooms. Type: Organic Champignons Place of Origin: Serbia Weight(kg): 10
Dried shiitake mushroom lentinus edodes, whole, slices, stems, powder, granules etc, varies specs and grades available.
We cultivate best quality cordyceps militaris. We stock in dry raw form. As a trusted and reliable supplier, we are confident that our product will meet and exceed your expectations. Contact us for your order.
Cordyceps mycelium is freeze-dried, suitable for long-term preservation during daily use. Dried mushrooms can be used to brew tea, or processed like fresh mushrooms. Use an average of 0.2 - 0.4 gr per day, equivalent to 4 - 10 mycelium. Specification: WHOLESALES ONLY packaging following Order (from 2kg). For testing 10gram/ Bag or Jar. Expiry date: 3 years from date of manufacture 1. USES: Helps increase libido for both sexes, supports treatment of premature ejaculation; Helps prevent and support cancer treatment; Helps to lose weight, beautiful skin; Helps prevent and support the treatment of cardiovascular diseases, diabetes; Helps support liver and kidney function; Helps stabilize blood sugar. Support patients to quickly recover health 2. INGREDIENTS: 100% Cordyceps in the form of dried sublimation fibers. Cordycepin: see on testing result attached. Adenonsine: see on testing result attached. 3. INSTRUCTIONS FOR USE: Mix water: use 3-5 stalks of mushrooms, put in 150-200 ml boiling water, wait 2-3 minutes for the active ingredients in the mushrooms to be extracted into tea, use both water and mushrooms. Can be used 1-2 times per day depending on need. Cooking porridge / soup: used as an ingredient to cook porridge or nutritious soup, using 3 - 5 mushroom stalks/cup. Use 1-2 cups/day. Suitable for everyone, men and women, the elderly, sick people needing support or healthy people needing supplements. 4. STORAGE: Store in a cool, dry place, away from sunlight. 5. PRODUCTION PROCESS is strictly controlled: from growing mulberries, raising silkworms to cultivating mushrooms and processing products.. to ensure quality standards and easy traceability.
Pure and organic with all required certificate of products 100% original and certificate will be provided


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Chris Harrison Gave The Most Bleak Interview About Peter & Madi's Future
You would think Bachelor host Chris Harrison — who's been helping singles fall in love for nearly 18 years — would be a romantic. However, just days after The Bachelor Season 24 finale, Chris Harrison said Peter Weber and Madison Prewett's future together doesn't seem promising to him, and I'm seriously shook. After all, he was the one who flew to Prewett's hometown of Auburn, Alabama, without Weber's knowledge, hoping to convince her to give the pilot another chance. Harrison was also the one who said he was "shocked" and "saddened" by Barb Weber's harsh criticism of the couple. But now the host is admitting what he really thinks about Weber and Prewett, and he's not holding back.
To be fair, Harrison wished the pair well at the end of the live show, and he genuinely seems to be rooting for them. Unfortunately, as he admitted during a March 11 interview with Us Weekly, he isn't holding out hope they'll last. "Look, it's easy to get on social media and rip them apart and tell everybody they're not gonna make it," he said. "Odds are, they aren't." Who would have thought the guy who encourages strangers to get engaged two months after meeting would be a realist? (Elite Daily reached out to reps for Weber and Prewett for comment on the future of their relationship and did not hear back in time for publication.)
Even more surprising is the fact that Harrison doesn't even see his own relationship lasting long-term. Though he's been dating Entertainment Tonight senior producer Lauren Zima for over a year now, he told Us Weekly that he doesn't see them walking down the aisle anytime soon... or maybe ever. "Odds are me and my girlfriend aren't [going to last]," he added. "That's life." Oh, and did I mention Zima was his date at the Seagram's Escapes Tropical Rosé launch party where Harrison gave his bleak prediction about their relationship? #Awkward.
While the Bachelor host doesn't seem to be feeling particularly optimistic about Pilot Pete's relationship or his own, he did say he doesn't see the point in all the online hate Weber and Prewett have been getting. "When they break up or if they break up or if they get married, we can all talk about that," he said. "But right now, what do you get from telling them they suck? They know the score." Do they? Neither Weber nor Prewett have said anything about their own hope for the future since "After the Final Rose," so Bachelor Nation fans will just have to see whether they exceed Harrison's (and Mama Barb's) expectations.


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Our company attaches great importance to the shopping experience of each customer. Package includes-includes 1 x w10120998 clothes dryer lint filter. If you have any questions during shopping, please contact customer service in time. Premium quality - upgraded w10120998 dryer lint screen Filter Assembly traps lint and debris from the exhaust air flowing from the dryer. The upgraded filter is made of high-quality stainless steel.
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Ultra Durable W10120998 Dryer Lint Filter Replacement Part By Blue Stars, Replaces 1206293 3390721 8066170 8572268 PS1491676 AP3967919, Exact Fit for Whirlpool & Kenmore Dryers #adBlueStars #ad
- This part fixes the following symptoms: Takes too long to dry | No heat or not enough heat | Shuts off too soon | Marks left on clothes. Premium quality: the replacement part is made from durable high-quality material and well-tested by the manufacturer - Meets OEM standards - Ensure long-lasting and effective performance.
Easy to install: it is made exactly fit for most top name brands kenmore, 8066170, w10596627, 3390721, inglis, w10120998vp, admiral and replaces part numbers: 206293, w10120998, amana, W10049370, crosley, 8572268, w10120998, w10178353, whirlpool, KitchenAid, AP3967919, Maytag, PS1491676.
Model number: w10120998 Dryer Lint Filter. When replacing the lint filter, check the filter slot for a buildup of lint, which can be a fire hazard.
180-day money-back warranty: for any reason, you're not completely satisfied, you can ask for a replacement or full refund, no questions asked. Continue to check often to make sure the filter and slot are both cleared of lint. Save time save money: inexpensive way to fix or repair a dryer. Replacing the lint filter is an easy repair which requires no tools.
|Model||W10120998 1206293 3390721 8066170|
4. APPLIANCEMATES #ad
W10120998 Dryer Lint Filter Catcher Stainless Steel Screen Mesh for Whirlpool Kenmore/Elite he3 Dryer Lint Screen Replacement Part W10049360, 8066170 with Clothes Dryer Lint Vent Trap Cleaner Brush #adAPPLIANCEMATES #ad
- Any questions, please feel free to contact us. Replaces part numbers 206293, 8572268, w10178353, ap3967919, w10049370, w10596627, 8066170, w10120998, w10120998, w10120998vp, 3390721, PS1491676. Dryer lint trap replacement this whirlpool dryer lint screen for part numbers: w10120998, ps1491676 etc.
What you get 100 satisfaction guarantee. We are here to help. 12-month warranty. Perfectly works for wed5500xw0 cabrio dryer, w10049360, medx600xw0, wplw10120998, 8066170, AP3967919, wed9200sq0, medb880bw0, wed9400sw0.
Wide compatibility the dryer lint screen w10120998 widely compatible with whirlpool manufactured brands whirlpool cabrio, 3RAED3005TQ0, wed5500xw0, 3000 series, MLE20PDAZW0, mlg20praww0, and 5000 series etc. Here are some models for your reference: mede300vw0, MLE20PRAZW0, elite he4, duet series, MLG20PDAWW0.
There is 1 x w10120998 dryer lint screen filter Catcher + 1 x Clothes Dryer Lint Vent Trap Cleaner Brush in the package. Upgraded - quality w10120998 dryer screen replacement, designed to meets or exceed the OEM standard, featured a premium durable construction ABS Frame Construction & Metal STAINLESS STEEL Screen and well-tested by the manufacturer designed to offer a durable and reliable dryer replacement parts.
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Kenmore, W10120998 Dryer Lint Screen Filter. Replacement For Whirlpool, Sears Dryer, Roper #adnewlifeapp #ad
- The lint filter traps lint and debris from the exhaust air flowing from dryer. This part works with the following brands: whirlpool, modern maid, Magic Chef, Estate, Hardwick, KitchenAid, Roper, Maytag, Admiral, Jenn-Air, Norge, Inglis, Amana, kenmore, Crosley, Caloric & Ikea.
W10120998 dryer lint filter. Replaces old numbers: 1206293, b00gllspky, 8066170, b005ar70o2, eap1491676, w10178353, b0156ndpuc, 70-9e5o-6wpf, bc-ukaq-5pwy, ps1491676, w10049370, ap3967919, ah1491676, j4-k9u5-6uwl, 8572268, 3390721, ea1491676, W10596627.
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- It can fix following problem: takes too long to dry. No heat or not enough heat. It fits for whirlpool, amana, Crosley, Maytag, Inglis, kenmore, Admiral and more brands dryer. For any reason you are not completely satisfied, you can request a replacement or a full refund.
Package includes 1 x w10120998 Dryer Lint Screen Filteracement. Shuts off too soon. Marks left on clothes. It replaces ps1491676, w10049360, 8066170, w10049370, 8066170, ap3967919, w10596627, 1206293 3390721, eap1491676, ah1491676, ea1491676, 8572268, w10178353.
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Compatible with Part Number AP3967919 PS1491676, Jolaxy W10120998 Lint Filter Replacement for Kenmore Maytag Whirlpool Dryers, Ultra Durable Dryer Lint Screen Trap #adJolaxy #ad
- Package contents: 1 x w10120998 Dryer Lint Filter One-year Warranty. This w10120998 high-quality exact equivalent part is just right for the job, cracked or broken lint filter. 100% brand new and high quality: a lint filter not only filters the air inside the dryer, and will be an ideal replacement for your old, but also traps any lint and debris.
More efficiency: featured with durable plastic construction, this filter can catch and trap lint for your dryer, which helps increase airflow to maximize drying efficiency and reduce drying times.
Part of the compatible model numbers have been listed in the description. You need to replace the lint filter if the frame cracks or the screen gets a tear in it.
Compatible model number: w10120998 lint filter can work for kenmore, may-tag and Whirlpool Dryers. Compatible part number: 1206293, w10049370, w10049360, w10120998vp, ps1491676, w10178353, 8066170, ap3967919, eap1491676, 3390721, 8572268, W10596627. If you are not sure whether this lint filter can work for your dryer, please feel free to contact us, we will help you confirm it. Never operate the dryer without a lint filter in place.
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W10049370, Roper & Sears Dryers. Replace for 1206293, Kenmore, W10120998 Dryer Lint Screen Filter, Compatible with Whirlpool, 3390721, 8572268, 8066170, PS1491676, W10596627, W10178353 #adSeentech #ad
- Buy with confidence:for any reason you're not completely satisfied, you can ask for a replacement or full refund. Premium quality: the replacement part is made from durable high-quality material and well-tested by the manufacturer.
Part number: w10120998 Dryer Lint Filter. Compatible: compatible with most top brand dryers: Kenmore, Whirlpool, Amana, Maytag, Inglis, KitchenAid, Crosley, Admiral.
Replace for part no: ps1491676, 3390721, bc-ukaq-5pwy, ap3967919, b005ar70o2, 8066170, w10049370, 8572268, b0156ndpuc, w10178353, eap1491676, w10596627, ea1491676, b00gllspky, 70-9e5o-6wpf, ah1491676, 1206293, j4-k9u5-6uwl.
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Kenmore and Roper, Sears Dryers W10120998, Noa Store Dryer Lint Screen Filter Compatible with Whirlpool #adNoa Store #ad
- Replacement dryer lint screen for Whirlpool; Model number W10120998. It has a reinforcement bar and also replaces old part number W10049370 The filter screen on is thicker and appears to be more durable then part number 8066170 There is a felt gasket across 3/4 of the back.
Designed to fit specific Whirlpool manufactured Dryer models including Roper, Estate & Sears Kenmore brands. Replacement for numbers ap3967919 and ps1491676.
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Catcher Replaces 3390721 8066170 8572268 1206293 AP3967919 PS1491676 EAP1491676 PD00002655, W10120998 Dryer Lint Screen Filter Catcher for Whirlpool Kenmore Admiral Amana Crosley Inglis #adKONDUONE #ad
- The filter collects lint during the drying cycle. If the lint screen filter fails on your dryer, feel freely to contact us. Approximate size: 12. 11" wide x 1073" long. New improved design with a reenforcement strip down the center of the filter.
Warranty & support - truly worry-free 6-month warranty and friendly customer service. Air flow is vital to proper dryer operation. Please check your appliance model and confirm the compatibility before ordering.
Compatibility - this w10120998 filter is used for many whirlpool, kenmore, Maytag dryers. Replaces part number - w10120998, 3390721, w10178353, 1206293, w10049370, w10049360, 8572268, ps1491676, eap1491676, w10120998vp, ap3967919, w10596627, 8066170, pd00002655, etc.
Dryer lint screen - w10120998 dryer lint screen filter, includes felt seal. Excellent product performance - made from high-quality material and well-tested before shipping. The lint filter should be cleaned before every load and replaced if damaged. While this is not a genuine whirlpool W10120998 dryer lint filter, it will fit perfectly like the original.
|Part Number||FBA 50000070|
|Model||W10120998 1206293 AP3967919 PS1491676|


Straight edge band from Western Germany. In the vein of mid-late 90’s emo/post-hardcore bands. Groovy mid-tempo rhythms filled with catchy melodies and thick chugging parts. This 7″ was released in time of Spring ’13 tour with barren. Second recording after their amazing debut 12″ on Cobra Records.


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(1 Recipe) Created by AN9E1AC
Recipes in this Collection
This is an amazing, healthy alternative to grandma's stuffing! My girlfriend said she added cranberries, apples and walnuts to it and really loved it. I have not tried that yet, but go crazy and see if you like it.
Submitted by AN9E1AC
Carbs: 33.9g | Fat: 3.2g | Fiber: 6g | Protein: 6.5g | Calories: 179.2


text:
Exploring the Therapeutic Potential of Metformin in Cirrhotic Patients with Diabetes: Safety, Efficacy, and Future Directions
Cirrhosis is a leading cause of mortality, responsible for over 29,000 deaths annually in the United States and one million deaths worldwide. It ranks as the 12th leading cause of mortality in the U.S. and globally 1, 2. Type 2 diabetes mellitus (T2DM) is a chronic disease that poses a significant public health challenge worldwide and can lead to complications in vital organs 3. In patients with chronic liver disease (CLD), the prevalence of diabetes is high, with approximately 30%–60% of cirrhotic patients having diabetes mellitus. Liver cirrhosis significantly impairs glucose homeostasis, primarily through a defect in glucose uptake, resulting in marked and sustained hyperglycemia. Diabetes is not only highly prevalent in patients with cirrhosis but is also an independent risk factor for poor prognosis. It is associated with the occurrence of major complications of cirrhosis, such as ascites, encephalopathy, renal dysfunction, bacterial infection, and hepatocellular carcinoma. Hence, it is crucial to systematically screen patients with cirrhosis for diabetes 4,5.
The management of diabetes in cirrhosis is hindered by the lack of guidelines and insufficient clinical data on the use of antidiabetic drugs. This review seeks to address the practical management of diabetes using metformin in cirrhosis by analyzing the existing literature.
In this context, the use of metformin, a commonly prescribed oral hypoglycemic agent, in cirrhotic patients with diabetes requires careful consideration. Concerns have been raised regarding the safety of metformin in patients with liver impairment, particularly due to the potential risk of lactic acidosis. As a result, metformin is often discontinued once cirrhosis is diagnosed. However, the evidence linking metformin to liver injury is weak. The incidence of lactic acidosis in diabetic patients treated with metformin is low, ranging from approximately 0.03 to 0.5 cases per 1,000 patient-years. Furthermore, the incidence of lactic acidosis among diabetic patients who take metformin does not differ significantly from the incidence in patients not receiving metformin. Most of the reported cases of lactic acidosis in patients with liver disease are limited to cirrhotic patients who were actively drinking alcohol, which may not represent the general population with cirrhosis and diabetes 6–9.
Despite these concerns, some studies have shown potential benefits of metformin use in the management of diabetes in cirrhosis. These benefits include improved survival, lower risk of hepatocellular carcinoma (HCC), and lower incidence of hepatic encephalopathy. The FDA-approved label for metformin includes a warning about lactic acidosis in patients with hepatic insufficiency, but there is limited evidence supporting this risk 10. Studies assessing the safety and pharmacokinetics of metformin in patients with CLD have shown that plasma metformin and lactate concentrations remain below the safety thresholds, indicating no significant risk of lactic acidosis. These findings suggest that concerns regarding unsafe metformin concentrations in patients with cirrhosis are unwarranted 4, 11.
Emerging evidence supports the continuation of metformin usage in diabetic patients with cirrhosis. A retrospective study investigated the potential effects of metformin on liver inflammation and carcinogenesis and proposed that the continuation of metformin usage after the diagnosis of cirrhosis could lead to improved survival outcomes for diabetic patients. The study included a total of 250 patients, of whom 172 continued metformin while 78 discontinued its use. The findings revealed that patients who continued metformin exhibited a significantly longer median survival compared to those who stopped it (11.8 vs. 5.6 years overall, p< 0.0001; 11.8 vs. 6.0 years for Child A patients, p= 0.006; and 7.7 vs. 3.5 years for Child B/C patients, p= 0.04, respectively). Importantly, even after adjusting for other variables, the continuation of metformin remained an independent predictor of better survival, with a hazard ratio (HR) of 0.43 (95% confidence interval [CI] 0.24 to 0.78; p= 0.005). Notably, no patients developed metformin-associated lactic acidosis during the follow-up period 6.
In another retrospective study involving 191 diabetic patients with biopsy-proven non-alcoholic steatohepatitis (NASH) and advanced fibrosis, the impact of metformin use was examined. Among these patients, 100 were long-term metformin users, while 81 were non-users. The findings revealed that metformin use was associated with a lower risk of overall mortality/transplant (HR 0.42; 95% CI 0.24 to 0.74, p= 0.003) as well as a reduced risk of hepatocellular carcinoma (HR 0.25; 95% CI 0.11 to 0.58; p= 0.001). These associations remained significant even after propensity-score and covariate-adjusted analyses. Importantly, no cases of hepatotoxicity or lactic acidosis were observed. The study provides evidence that long-term metformin use is associated with a decreased risk of all-cause mortality/transplantation and hepatocellular carcinoma in diabetic patients with NASH and advanced fibrosis 12.
Metformin has demonstrated a protective effect against the development of cancer and cancer-related mortality in patients with type 2 diabetes. Specifically, metformin use has been associated with a decreased risk of HCC development in diabetic patients with chronic liver disease. Furthermore, metformin has been independently linked to a reduction in liver-related death in patients with T2DM and hepatitis C virus (HCV)-induced cirrhosis 6.
The incidence of HCC is significant, with approximately 850,000 new cases reported annually, making it the fifth most common cancer worldwide 13. Given the elevated risk of liver cancer in diabetic patients, metformin has gained considerable interest as a potential chemopreventive agent. A meta-analysis conducted in 2017 aimed to investigate the impact of metformin use on liver cancer risk in individuals with diabetes. This analysis, incorporating 19 studies involving 550,882 diabetic subjects, revealed a 48% reduction in the incidence of liver cancer among metformin users compared to non-users (odds ratio [OR] 0.52; 95% CI 0.40 to 0.68). These findings suggest that metformin may have a protective effect against liver cancer in diabetic patients 14.
In patients with T2DM and HCV cirrhosis, the use of metformin has been independently associated with a reduced incidence of HCC and liver-related death or transplantation 15. A meta-analysis of ten studies involving a total of 334,307 patients with 2DM, including 22,650 cases of HCC, revealed a significant 50% reduction in HCC incidence associated with metformin use 16. Compared to treatment with sulphonylureas or insulin, metformin was associated with a significantly lower risk of HCC in both the cirrhosis group (OR 0.16; p= 0.0006) and the control group (OR 0.15; p= 0.005) 17. These findings highlight the potential benefit of metformin as an adjunctive therapy for diabetic patients with CLD, particularly in reducing the risk of HCC and improving patient outcomes.
Similarly, in a 2021 study involving 1,061 cirrhotic patients with T2DM, the use of metformin was associated with a lower incidence of HCC. Among the 719 patients who were exposed to metformin, 17.4% developed HCC, while 37.4% of the 342 patients without metformin exposure developed HCC. Furthermore, the study demonstrated that metformin use was independently associated with a reduced risk of HCC, as determined through multivariate analysis (HR 0.48; 95% CI 0.36 to 0.61; p< 0.001). Moreover, survival analysis of 327 HCC patients revealed that metformin exposure was associated with a longer median survival time (6.9 years vs. 3.88 years; p= 0.003) and improved univariate survival (HR 0.63; 95% CI 0.45 to 0.88; p= 0.006). These findings suggest that the use of metformin in cirrhotic patients with T2DM may not only lower the incidence of hepatocellular carcinoma but also potentially extend survival. Therefore, considering the absence of contraindications, the continued use of metformin should be taken into consideration as part of the treatment strategy for these patients 3.
In another cohort study conducted in 2021 involving 857 patients diagnosed with HCC, the impact of metformin on HCC recurrence was investigated. Among these patients, 222 had T2DM. The study followed these patients for an average of 75 months and found that 54.9% of the patients experienced HCC recurrence, while 18.4% died during the follow-up period. Multivariate analysis was performed to identify independent predictors of recurrence-free survival (RFS). Among the patients with diabetes, high HbA1c levels (>9%), hypoalbuminemia, and vascular invasion were identified as independent risk factors for HCC recurrence. However, the use of metformin did not show a significant impact on HCC recurrence in these diabetic patients who had undergone initial liver resection 13.
Hepatic encephalopathy is one of the major complications of liver cirrhosis, affecting one-third of cirrhotic patients. In a 2012 retrospective cohort study, the influence of metformin use on liver dysfunction and hepatic encephalopathy was investigated in diabetic cirrhotic patients. The study included 82 cirrhotic patients with type 2 diabetes, with 41 patients classified as metformin users and 41 as controls (diabetic cirrhotic patients without metformin treatment). It was found that hepatic encephalopathy occurred in 23.2% with metformin vs. 41.5% without metformin (p= 0.002). They also studied the in vitro glutaminase activity inhibition in colonic epithelial mammalian cell line and found that metformin decreased glutaminase activity up to 24% at 72 h post-treatment (p< 0.05). These findings suggest that metformin use may be protective against hepatic encephalopathy in diabetic cirrhotic patients, possibly through its inhibitory effect on glutaminase activity 18.
Additionally, portal hypertension is a major factor contributing to clinical decompensation in patients with liver cirrhosis. A randomized, double-blind study examined the acute effects of metformin on hepatic venous pressure gradient (HVPG) and liver perfusion. The study included 32 patients with cirrhosis who were given either 1000 mg of metformin or a placebo, and HVPG and liver perfusion were assessed before and 90 minutes after ingestion. The results showed that the metformin group had a mean relative decrease in HVPG of 16%, while the placebo group had a mean increase of 4% (p= 0.008). In patients with baseline HVPG ≥12 mm Hg, a clinically significant improvement in HVPG (HVPG <12 mm Hg or >20% reduction) was observed in 46% of metformin-treated patients compared to 8% of placebo-treated patients (p= 0.07). No significant changes were observed in systemic blood pressure, heart rate, liver hemodynamics, or inflammatory markers between the two groups. The study suggests that a single oral dose of metformin acutely reduces HVPG in patients with portal hypertension without affecting systemic or liver hemodynamics or inflammatory biomarkers. This finding presents a promising perspective for a safe and cost-effective treatment option, which should be further investigated in larger clinical studies with long-term outcomes in patients with cirrhosis and portal hypertension 19.
However, a recent population-based study from the Taiwan National Health Insurance Research Database by Yen et al. found that metformin use was associated with higher risks of mortality and decompensation in patients with compensated cirrhosis. In this 2022 study comparing metformin users and non-users with diabetes and cirrhosis, the incidence rates of all-cause mortality and cirrhotic decompensation were evaluated. The study found that metformin users had slightly higher rates of mortality and cirrhotic decompensation compared to non-users, with adjusted hazard ratios (aHR) of 1.13 and 1.15, respectively. There was a significantly higher risk of death in those who received >1,000 mg of metformin per day, while those who took ≤1,000 mg did not have higher risks. The study suggests that metformin use may be associated with higher risks in patients with compensated liver cirrhosis and highlights the need for prospective studies to confirm these findings. This study lacked complete information on factors such as body weight, alcohol consumption, smoking, physical activity, and family history, which could influence the observed outcomes. The use of clinical diagnosis instead of biochemical results to classify the severity of liver cirrhosis is another limitation. Overall, the study suggests that caution should be exercised, especially with higher doses of metformin, and lower doses may be considered for patients with cirrhosis. Prospective randomized studies are necessary to validate these results and address potential confounding factors 20.
In conclusion, the available epidemiological and clinical evidence suggests several positive effects associated with the use of metformin in patients with T2DM and cirrhosis. These benefits include an increased rate of survival, reduced all-cause mortality, and a decreased risk of HCC development. However, caution should be exercised when considering metformin use in patients with moderately or severely impaired liver function to avoid the potential complications of lactic acidosis. Patients with multiple comorbidities, who are at a higher risk of lactic acidosis, should be particularly monitored closely. Based on the available data, it may be reasonable to prescribe metformin in lower doses for patients with cirrhosis, taking into account the potential benefits and the need for caution. Healthcare providers should carefully evaluate decompensated patients with borderline renal function and avoid metformin use in cirrhotic patients with an estimated glomerular filtration rate (eGFR) of less than 30 ml/min/1.73 m2. It is important to note that individual patient factors, including liver function, renal function, and overall comorbidity profile, should be taken into consideration when making decisions regarding metformin use in patients with cirrhosis. Regular monitoring and close medical supervision are crucial to ensure patient safety and optimize treatment outcomes.
 Miniño AM, Murphy SL, Xu J, Kochanek KD. Deaths: final data for 2008. Natl Vital Stat Rep. 2011 Dec 7;59(10):1–126. PMID: 22808755.
 Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 [published correction appears in Lancet. 2013 Feb 23;381(9867):628. AlMazroa, Mohammad A [added]; Memish, Ziad A [added]]. Lancet. 2012;380(9859):2095–2128. doi:10.1016/S0140–6736(12)61728–0
 Tangjarusritaratorn T, Tangjittipokin W, Kunavisarut T. Incidence and Survival of Hepatocellular Carcinoma in Type 2 Diabetes Patients with Cirrhosis Who Were Treated with and without Metformin. Diabetes Metab Syndr Obes.
 Puri P, Kotwal N. An Approach to the Management of Diabetes Mellitus in Cirrhosis: A Primer for the Hepatologist. J Clin Exp Hepatol. 2022;12(2):560–574. doi:10.1016/j.jceh.2021.09.010
 Boursier J, Anty R, Carette C, Cariou B, Castera L, Caussy C, Fontaine H, Garioud A, Gourdy P, Guerci B, Guillaume M, Michot N, Minello A, Ouizeman DJ, Serfaty L, Bonnet F, Vergès B, Petit JM; AFEF and SFD. Management of diabetes mellitus in patients with cirrhosis: An overview and joint statement. Diabetes Metab. 2021 Sep;47(5):101272. doi: 10.1016/j.diabet.2021.101272. Epub 2021 Aug 4. PMID: 34363981.
 Zhang X, Harmsen WS, Mettler TA, et al. Continuation of metformin use after a diagnosis of cirrhosis significantly improves survival of patients with diabetes. Hepatology. 2014;60(6):2008–2016. doi:10.1002/hep.27199
 Salpeter SR, Greyber E, Pasternak GA, Salpeter Posthumous EE. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD002967. doi: 10.1002/14651858.CD002967.pub3. Update in: Cochrane Database Syst Rev. 2010;(4):CD002967. PMID: 20091535.
 Miralles-Linares F, Puerta-Fernandez S, Bernal-Lopez MR, Tinahones FJ, Andrade RJ, Gomez-Huelgas R. Metformin-induced hepatotoxicity. Diabetes Care. 2012;35(3):e21. doi:10.2337/dc11–2306
 Chidiac J, Kassab R, Iskandar M, Koubar S, Aoun M. Metformin-Associated Lactic Acidosis in a Diabetic Patient with Normal Kidney Function and Occult Cirrhosis. Case Rep Crit Care. 2022;2022:5506744. Published 2022 Oct 5. doi:10.1155/2022/5506744
 Metformin hydrochloride tablet. Prescribing information. Granules India Ltd; 2023.
 Smith FC, Stocker SL, Danta M, et al. The safety and pharmacokinetics of metformin in patients with chronic liver disease. Aliment Pharmacol Ther. 2020;51(5):565–575. doi:10.1111/apt.15635
 Vilar-Gomez E, Vuppalanchi R, Desai AP, et al. Long-term metformin use may improve clinical outcomes in diabetic patients with non-alcoholic steatohepatitis and bridging fibrosis or compensated cirrhosis. Aliment Pharmacol Ther. 2019;50(3):317–328. doi:10.1111/apt.15331
 Cho WR, Wang CC, Tsai MY, et al. Impact of metformin use on the recurrence of hepatocellular carcinoma after initial liver resection in diabetic patients. PLoS One. 2021;16(3):e0247231. Published 2021 Mar 4. doi:10.1371/journal.pone.0247231
 Ma S, Zheng Y, Xiao Y, Zhou P, Tan H. Meta-analysis of studies using metformin as a reducer for liver cancer risk in diabetic patients. Medicine (Baltimore). 2017;96(19):e6888. doi:10.1097/MD.0000000000006888
 Nkontchou G, Cosson E, Aout M, et al. Impact of metformin on the prognosis of cirrhosis induced by viral hepatitis C in diabetic patients. J Clin Endocrinol Metab. 2011;96(8):2601–2608. doi:10.1210/jc.2010–2415
 Singh S, Singh PP, Singh AG, Murad MH, Sanchez W. Anti-diabetic medications and the risk of hepatocellular cancer: a systematic review and meta-analysis. Am J Gastroenterol. 2013;108(6):881–892. doi:10.1038/ajg.2013.5
 Donadon V, Balbi M, Mas MD, Casarin P, Zanette G. Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease. Liver Int. 2010 May;30(5):750–8. doi: 10.1111/j.1478–3231.2010.02223.x. Epub 2010 Mar 12. PMID: 20331505.
 Ampuero J, Ranchal I, Nuñez D, et al. Metformin inhibits glutaminase activity and protects against hepatic encephalopathy. PLoS One. 2012;7(11):e49279. doi:10.1371/journal.pone.0049279
 Rittig N, Aagaard NK, Villadsen GE, Sandahl TD, Jessen N, Grønbaek H, George J. Randomised clinical study: acute effects of metformin versus placebo on portal pressure in patients with cirrhosis and portal hypertension. Aliment Pharmacol Ther. 2021 Aug;54(3):320–328. doi: 10.1111/apt.16460. Epub 2021 Jun 24. PMID: 34165199.
 Yen FS, Huang YH, Hou MC, et al. Metformin use and cirrhotic decompensation in patients with type 2 diabetes and liver cirrhosis. Br J Clin Pharmacol.

domain: literature


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