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Anti-malaria drug hydroxychloroquine fails another test as a Covid-19 treatment, says study
Anti-malaria drug hydroxychloroquine has failed another test to check its efficacy in treating the coronavirus disease (Covid-19), a new study has revealed, with patients admitted to hospitals showing no change in their conditions after being administered the medicine.
The observational study published in the highly cited New England Journal of Medicine (NEJM) showed that doctors reported that the use of hydroxycholoquine neither lessened the need for patients requiring breathing assistance nor the risk of death.
The study said there were no potential benefits or harm from the drug, which was given to 1,376 consecutive patients in the emergency room with Covid-19 symptoms in the New York-Presbyterian Hospital and Columbia University Irving Medical Center in New York City.
The NEJM study found that the risk of intubation or death was not significantly higher or lower among consecutive patients who were given hydroxychloroquine compared to those who were not given the drug. “There was no significant association between hydroxychloroquine use and intubation or death,” the study concluded.
The findings come two weeks after the US Food and Drug Administration warned the public against using hydroxychloroquine and chloroquine without prescription or supervision because of reports of “serious heart rhythm problems” in patients treated with the malaria drugs.
“There is still no convincing evidence for treatment. To rule out unmeasured confounding and bias, randomised-control trial evidence in larger numbers is needed, such as from multi-country solidarity trial being conducted by World Health Organization,” said Dr K Srinath Reddy, president, Public Health Foundation of India. India is among the countries testing the safety and efficacy of hydroxychloroquine as part of the solidarity trial.
Observational studies aren’t considered as conclusive as randomised-controlled trials because clinicians often use several drugs and therapies to treat patients. More rigorous clinical trials are needed to establish the effectiveness of the drug, said the NEJM study, which was funded by the US National Institutes of Health.
Hydroxychloroquine is the only drug approved for treating hospitalised Covid-19 patients in India, where it is given in combination with the antibiotic azithromycin. It is also being given to health care workers and people at risk of exposure as a prophylaxis for Covid-19, which leads to potentially fatal complications in some patients.
The cheap and widely available drug that has been used to treat malaria for at least a century emerged as the most sought-after medicine after two preliminary trials in Covid-19 patients in China in March showed it boosted recovery and lowered the severity of Covid-19.
An early study from France also showed benefit of hydroxychloroquine in 26 patients treated at French hospitals, but flaws in study design made it difficult to interpret. The studies were published in medRxiv, a pre-print website that publishes studies before peer-review to expedite access to new research.
An analysis published in the journal Annals of Internal Medicine in March, however, said the “data to support the use of hydroxychloroquine and chloroquine are limited and inconclusive.”
Apart from malaria, hydroxychloroquine is prescribed for rheumatoid arthritis and lupus. Several countries including India, China, France, South Korea, Italy, India and the United States are using anti-malarials to treat people severely ill with Covid-19.
US President Donald Trump has touted the drug as a “game changer” in the fight against Covid-19.
Anti-malarials work by decreasing the acidity in endosomes, which are compartments within cells that some viruses hijack to enter the cell and cause infection. The doorway used by Sars-Cov-2 is the spike protein on its surface that it uses to attach to a receptor on the surface of human cells, but studies in cell culture have suggested chloroquines have some activity against the virus.
The doses needed to treat Covid-19 are usually very high, which raises risk of toxicities, which led a small study in Brazil being suspended after researchers found high doses led to irregular heartbeats (heart arrhythmia).
Last week, Gilead Sciences’ antiviral drug remdesivir became the first drug to get emergency use authorisation in the US for treatment of Covid-19. The move came after the US National Institute of Allergy and Infectious Diseases released results from its study showing Covid-19 patients who took remdesivir usually recovered after 11 days, four days faster than those who didn’t take the drug.


News Desk: The government has decided to celebrate the inauguration of the Padma Bridge in all the 64 districts of Bangladesh simultaneously on June 25.
There will be common programmes, including a laser show in Dhaka's Hatirjheel, all around to mark the memorable occasion.
Special programmes will be arranged in four districts Munshiganj, Madaripur, Shariatpur, and Dhaka for five days.
In a video conference on Friday, the Cabinet Division asked all the deputy commissioners to make necessary arrangements for the said programmes.
Road transport and bridges minister Obaidul Quader and cabinet secretary Khandker Anwarul Islam were present in the meeting.


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A 42-year-old British woman was recently reported to have committed suicide, and although she announced her intention to do so in a status update on Facebook, none of her 1,000+ friends even thought to check on her - despite some of them living in walking distance of her home!
Simone Back wrote the following message on the social networking site on Christmas Day:
"Took all my pills be dead soon bye bye everyone."
Most disturbing of all, however, is that instead of anyone picking up the phone or trying to check on her, many just responded to the status with messages like:
'She ODs all the time and she lies.'
'I hope that she is lying about this or you're going to feel guilty tomorrow.'
'Did you catch the part about Simone taking pills?? .. the 'bye bye' part?? Did anyone go by personally and check on Simone.. or call 999?? what's wrong with you people?? is the gossip really more important than her??'
'She does it all the time, takes all of her pills. She's not a kid anymore.'
'She has a choice and taking pills over a relationship is not a good enough reason.'
It wasn't until Back's mother, Jennifer Langridge, wrote the following message that people finally realized the seriousness of the situation:
'My daughter Simone passed away today so please leave her alone now.'
She later explained:
"Nobody told me anything about it until the following day when I was sent a text saying: 'get help.' I am disabled so can't get up the stairs to Simone's flat so I called the police straight away. It is upsetting to think nobody did anything for my daughter."
Unbelievable. And so tragic.
It seems clear that this woman was deeply troubled, but we think this says something quite serious about how people are using, and communicating with others, on websites like Facebook, and it's not a good thing.
We can't believe that someone would write something like that, and not ONE person who saw it would be so unconcerned that they'd not only ignore a cry for help, but openly mock it!
Our thoughts are with Simone's family during this difficult time.
Tags: christmas, comments, facebook, ignore, jennifer langridge, mockery, mother, post, simone back, social networking, status update, suicide, suicide note

domain: sociology


Updated: November 26, 2016 12:23:03 pm
Dear Zindagi starring Alia Bhatt and Shah Rukh Khan has collected Rs 8.75 cr on first day. Trade analyst Taran Adarsh shared, ” #DearZindagi has a STRONG start… Hi-end plexes of major centres contribute maximum… Fri ₹ 8.75 cr [1200 screens]. India biz.”
Earlier, the film saw good occupancy during morning shows. The film saw 45% occupancy in theatres across the country. Gauri Shinde-directed Dear Zindagi was released over 1200 screens in India and over 600 screens in the overseas market, making it a total of 1800 screens.
The film has already created a buzz over the unusual pairing of 51-year old Shah Rukh Khan and 23-year-old Alia Bhatt. The audience is also expecting a good film from Gauri Shinde who earlier directed English Vinglish starring Sridevi.
The film had a midweek release in UAE and collected Rs 1.19 crore on Wednesday. Dear Zindagi is expected to collect Rs 8-10 crore on the first day. Trade analyst Taran Adarsh shared, ” #DearZindagi had a midweek release in USA [Thanksgiving Weekend]… Collected an IMPRESSIVE $ 172,571 [₹ 1.19 cr] on Wednesday. @Rentrak.”
Meanwhile, it has got rave reviews from the audience and critics alike. People have given it thumbs up and have all praise for film’s lead cast – Shah Rukh Khan and Alia Bhatt.
#DearZindagi has a STRONG start… Hi-end plexes of major centres contribute maximum… Fri ₹ 8.75 cr [1200 screens]. India biz.
— taran adarsh (@taran_adarsh) November 26, 2016
— taran adarsh (@taran_adarsh) November 24, 2016
Dear Zindagi also stars Kunal Kapoor, Ali Zafar and Angad Bedi in important roles. Alia Bhatt portrays a modern girl who is endeavouring to find some kind of stability. After going through a series of unsuccessful relationships, Alia finds refuge in Shah Rukh Khan who plays a psychiatrist in the film.
Shubhra Gupta, film critic for The Indian Express wrote, ” What could have been a solid drama with emotional heft—the qualities that made Shinde’s debut ‘English Vinglish’ such an engaging watch–built upon the exploration of the fact that our adulthood is shaped by our childhood in ways we don’t really understand, turns into a kitchen sink talkathon.”
📣 The Indian Express is now on Telegram. Click here to join our channel (@indianexpress) and stay updated with the latest headlines
- The Indian Express website has been rated GREEN for its credibility and trustworthiness by Newsguard, a global service that rates news sources for their journalistic standards.


This is a week where we absolutely live up to the title of the show, with a crazy glut of random stuff, including reviewing Streets of Rage 4, talking the Assassin's Creed Valhalla announcement, and discussing our 6 Spoiler Commandments.
This is a week where we absolutely live up to the title of the show, with a crazy glut of random stuff to discuss, from Sean translating a video from Gundam’s 40th anniversary event, to Jonathan reaching a milestone reading One Piece, to Sean telling us about an awesome new anime called Keep Your Hands off Eizouken, to Jonathan talking about the wonders of finally playing Bayonetta, and so on back and forth for a good long while! Jonathan also reviews Streets of Rage 4, and we talk about several pieces of news, including the announcement of Assassin’s Creed Valhalla and The Last of Us Part II leaks, which leads to a discussion about our 6 personal commandments about spoilers in the modern world.
Intro/Politics Chat: 0:00:00 – 0:19:03
Adventures in Translating: 0:19:03 – 0:33:23
Stuff Smorgasbord: 0:33:23 – 1:27:17
News: 1:27:17 – 1:53:03
Spoiler Commandments: 1:53:03 – 2:17:22
Hatsune Miku: 2:17:22 – 2:23:57
Stream The Weekly Stuff Podcast Episode #327
Download 'The Weekly Stuff' Episode #327 as an MP3
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The Weekly Stuff with Jonathan Lack & Sean Chapman is a weekly audio podcast, and if you subscribe in iTunes, episodes will be delivered automatically and for free as soon as they are released. If you visit www.jonathanlack.com, we also have streaming and downloadable versions of new and archival episodes for your listening pleasure.


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Effective Animation and Visual Effects do not happen out of the blue, they are the result of accurate character and environment development, where art and technical directors make decisions before production phase.
- Narrative Script, tells the story before drawing or modeling.
- Color Script, making decisions on value and color before lighting or texturing.
- Storyboard, composition, animation and cameras in a 2D visualization process.
- Animatic, animating storyboard panels in 2D and 3D space to provide templates for animators and compositors.
- Character sheets, including views of the characters from multiple angles, recognizable silhouettes, orthographic views for the modelers, facial expressions for modelers and animators, clothes and gear sheets for prop modelers and visual effects artists, etc.
- Environment Sheets, including maps where characters can move in game levels defining what actions are possible and where they may take place.
- Concept art, sometimes using paintovers on rough 3D models, showing general looks and fine details of the future production, providing a thorough template for models, textures, light sets and post-production.
You make every decision during pre-production phase in an animation project, before production, in order to keep it manageable. It is easier (and more efficient) to fix problems in 2D before they happen in 3D.

domain: entertainment


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CHARLOTTESVILLE — For the first time in 2,917 days, Virginia won a postseason basketball game Wednesday night.
With two players on the bench in street clothes and another three either hurt or under the weather, the Cavaliers held off Brown 89-73 in the opening round of the NIT in University Hall. Travis Watson matched his career high of 29 points and Nick Vander Laan played one of his best games of the season before a crowd of 4,842.
With its first postseason victory since March 24, 1995, Virginia (16-15) advanced to the second round and will visit St. John's (17-13), a 62-57 winner over Boston University on Wednesday night.
According to the St. John's athletics web site, the game will be played at 7:30 p.m. Monday in Queens, N.Y.
"Tonight was a real character win for us," Virginia coach Pete Gillen said. "We were really beat up."
Jason Rogers, who had given Virginia a boost the past couple of games, was out with mononucleosis. Freshman Derrick Byars turned an ankle in practice this week and didn't play. Guard Todd Billet went 35 minutes despite a hip pointer he took in Friday's ACC tournament loss to Duke. Elton Brown was hampered by a sprained knee and Watson was battling a stomach flu.
"We knew we'd be short-handed," Vander Laan said. "We just wanted to leave everything on the floor."
Watson did -- literally. He vomited in the locker room at halftime and Gillen was concerned that his top scorer and rebounder wouldn't return. But Watson had 19 of his points and half of his 12 boards in the second half.
"I knew I was going to come back in," he said. "As long as I was able to see, I'd be OK."
Watson got some much-needed help. After not scoring in five of his previous seven games, Vander Laan finished with 13 points and nine rebounds. Devin Smith scored 14 points and helped limit Brown's Earl Hunt, the fourth-leading scorer in Ivy League history, to 5-of-13 shooting.
The Cavaliers shot 58.2 percent from the floor, their second-highest figure of the season.
"They shot 58 percent in both halves," Brown coach Glen Miller said. "That's the story of the game."
Though the Bears (17-12) had no answer for Virginia's size, they never gave up. The Cavs led by 12 points 51/2 minutes into the game but took only a 44-40 advantage to the locker room. Hunt's transition layup with 17:35 remaining made it a one-point game. But Virginia answered with a 10-0 run and kept the lead in double digits for the final 8:48.
Virginia had lost 12 consecutive games, including two NIT openers, since the end of the 1995-96 season, the longest stretch in school history. The victory was Gillen's first in the postseason since his Providence team advanced to the Elite Eight in 1997.
"It's good to get it over with," Gillen said. "But the best thing about it is we extended our season. We'll get to practice a couple more times and play at least one more game."
ST. JOHN'S 62, BOSTON UNIVERSITY 57
Willie Shaw scored 14 points as St. John's beat Boston University in New York.
Marcus Hatten added 12 points for the Red Storm, who are making their 27th NIT appearance and have won it a record five times.
Rashad Bell scored 18 points for the Terriers (20-11), the regular-season champions of the America East Conference.
Dave Johnson can be reached at 247-4649 or by e-mail at firstname.lastname@example.org. The Associated Press contributed to this report.

domain: news


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When it comes to dining with a view, Salty's Landing is tough to beat. As part of the Salty Brine Beach bath house,…More it is essentially on the beach, and has an outside seating area that offers outstanding views of Narragansett Bay, as well as a front-row seat to the Block Island Ferry as it transports tourists between the island and Point Judith. But it's not just location, location, location: Salty's Landing, which opened in May 2010, serves breakfast, lunch and dinner - or a quick bite between meals - concession-style and at great prices.
Owner Dan Murphy is hands-on and accommodating, and takes pride in using as many local vendors as possible. You'll find clam cakes, chowder, fish & chips and handmade stuffies on the menu, as well as other standard beach stand fare like burgers, sandwiches and fried items. Breakfast dishes include eggs, French toast and muffins. Salty's Landing also serves Baby Elliott's frozen lemonade for a cold treat to enjoy as you take in the view.
The Coast Guard House restaurant is rich in history. Originally built as a life-saving station for the U.S. Coast…More Guard, in 1945 an addition was built to transform the building into a delightful oceanfront restaurant. In 1979, the building was completely renovated into a year-round eatery with a fantastic deck that is open from mid-April through October.
Using only the freshest seafood delivered daily from the nearby Port of Galilee, The Coast Guard House serves delectable seafood dishes and American cuisine such as NY strip steaks and pan-roasted organic chicken.
Known for its outdoor deck where panoramic ocean views can be seen for miles, the spot is also known for its inspired cocktails such as the Beachcomber and Chocolate Aviator.
The Coast Guard House is also famous for their outstanding Sunday Brunch.

domain: geography


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- 6 cups 1-inch cubes seeded watermelon
- 3 tablespoons lime juice
- 1 cup water
- 1/2 cup sugar
- In 1-quart saucepan, mix lime juice, water and sugar.
- Cook over low heat about 5 minutes, stirring occasionally, until sugar is dissolved. Cool slightly, about 5 minutes.
- In blender or food processor, place watermelon. Cover; blend on high speed about 2 minutes or until smooth. Add lime juice mixture; blend until well mixed.
- Pour into 13×9 inch glass baking dish(ungreased).
- Cover; freeze for 1 hour.
- Scrape with fork to distribute ice crystals evenly. Every 30 minutes, repeat scraping procedure for at least 3 hours until mixture is consistency of fine ice crystals.
- Scoop into chilled dessert cups.
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domain: food


text:
Tales from the Home of the World’s Worst Weather
An infamous place of extremes, 6,288-foot Mount Washington, New Hampshire has been captivating audiences for hundreds of years.
While many places on Earth experience severe weather, few are inhabited by humans 24 hours a day, 365 days a year. Mount Washington Observatory has been operating a continuously-staffed scientific outpost on this remote peak since 1932, providing the Observatory many remarkable stories and an intimate knowledge of the mountain.
Through the years, the hardy men and women of the Observatory have experienced white-out blizzards, stunning 110-mile vistas, and everything in between. They have survived a 231mph wind gust, endless days of disorienting fog, and snow drifts more than 20 feet tall. They have worked with scientists and celebrities, students and snow rangers. They have amassed one of North America's longest continuous climate records, and developed an intimate understanding of the place known as the "Home of the World's Worst Weather."
Our educators will create a custom program, tailored to the specific interests of your group, and bring Mount Washington to you through breathtaking imagery and first-person narrative.
Programs can include such topics as:
- Life and work at the Mount Washington Observatory
- History and lore of Mount Washington
- The former 231mph world record wind
- Weather basics
- Forecasting basics
Please contact us for a quote.


7 July 2015 at 11:07 GMT
The ‘Diagon Alley’ attraction at Universal’s Wizarding World of Harry Potter theme park celebrated its first birthday this week. To mark the occasion, a special 3D street art display will be showcased at London’s Kings’s Cross. Check out some photos below.
Consumers will be able to ‘enter’ Diagon Alley and get a glimpse into J.K. Rowling’s wizarding world, with a photographer on hand to capture the special moment. The art was designed to showcase the newest addition to Universal Studios Florida at Universal Orlando Resort.
The Diagon Alley area of the park includes the new Harry Potter and the Escape from Gringotts thrill ride.


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Almost since I started blogging the most popular post on my blog has been this one - here - called Mollie Makes Pretty Rose Cross Stitch.
It was about using a kit that came with a magazine to make up a cross stitch picture. I actually made it into a pin cushion rather than a picture. I have no idea why it is so popular, but month after month, year after year, there it is, up there at the top of my most viewed posts list.
When I received another one of these kits, I assume again on Mollie Makes, I still didn't want to make a picture with it and I didn't want to make another pin cushion either. So it hung around in my boxes of fabric and yarn for a long time.
While sorting through the yarn and fabric early in August I found it again and decided to do something with it. Putting it together with a plastic embroidery hoop that I had from another - unmade! - kit I turned it into this.
A pretty picture with my initial - because my name really is Amy! - and a little border around the edge. Ta Dah!
I simply drew the letter on to the canvas with one of those disappearing fabric ink pens and then stitched over it in two colours of the floss that came with the kit. Then I added little crosses all around the edge to make the border, a little like a ring of flowers.
The back looks horrid, but I have covered it with a piece of felt to at least try and neaten it up a bit.
I have a couple of other kits that I have made up to produce some little pictures which I will also be sharing and then I will hang them all up somewhere in my office or prop them up on shelves around the house.
Do you think this post will make it to the top of my charts. I wonder!
This is one of the posts that I wrote in August to be published in September but publishing it got delayed by my need to take a blog break.

domain: artistic


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Part 2 of 2 –
Proper handling can prevent some damage to photographs. Clean, white cotton gloves should be worn while handling photographs. Oils from hands, lotions and other sources can mark the image’s surface and may not be reversible. Never use ink to mark photographs or enclosures. Instead, use a soft lead pencil on the reverse side of the photo.
CLEANING AND CARE
Since even the slightest abrasion can damage a photograph, it is important to use only a very soft, clean brush to dust the surface. Move from the center to the edges, not straight across. No solvents should be used as these can also damage and even remove the emulsion of the photograph. Should photographs adhere to framing glass or each other, do not try to separate them yourself. Contact an experienced photograph restorer/conservator as soon as possible. Do not attempt to mend tears by using ordinary tape, as this can damage the image.
Always keep the areas where photographs are handled or stored clean and pest-free. It is vital that collection areas be free of debris that might encourage pests. Food and beverages should not be stored near the photographs. Apart from the potential for attracting pests, accidental spills can irreversibly damage most photographic objects.
COMMON CONCERNS AND SOLUTIONS
Wet photographs: In many cases, wet photographs may be salvaged by very carefully separating them (if they appear stuck together, do not attempt to separate them since they may tear or pull emulsion from the support). Place pieces of wax paper (slightly bigger than the largest photo) between each photograph, put the stack of photos into a zip-lock bag and freeze the entire package until you can put in the hands of a trained photograph restoration specialist.
Soiled photographs or negatives: Brush soiled photographs carefully with a clean, soft brush. Proceed from the center of the photograph outward toward the edges. Do not attempt to clean photographs with water-based or solvent-based cleaners, such as window cleaner or film cleaner. Improper cleaning of photographic materials can cause serious and often irreversible damage such as permanent staining, abrasion, alteration or loss of binder and image.
Photographs or negatives adhered to enclosure: High-humidity environments or direct exposure to liquids can cause photographs to adhere to frame glass or enclosure materials. This is a very difficult problem to resolve and great care must be taken to reduce the possibility of further damage. If a photograph becomes attached to adjacent materials, consult a photographic materials conservator before attempting to remove the adhered materials.
Deteriorated negatives: Chemical instability is a major factor in the deterioration of early film-based materials. If film-based negatives are brittle, discolored, sticky or appear wavy and full of air bubbles, separate the negatives from the rest of the collection and consult a photographic materials conservator or photograph restoration specialist. A conservator can provide photo restoration and will be able to help identify these materials and make recommendations for their safe storage or duplication.
Broken Ambrotypes (old photo negatives on glass): Carefully place broken glass negative pieces in archival paper enclosures. Use a separate, clearly marked enclosure for each piece to reduce the possibility of scratching or further damaging the negative. Consult a photographic materials conservator or photograph restoration specialist for assistance.
In case you missed it: Part 1 – Caring for and displaying your keepsake photos
This blog is part of a continuing series offering advice on preserving, displaying and caring for art objects in your home. Additional information is available at the author’s website. See your local, independent insurance agent for advice on coverage to protect fine art and other items of value.
© Copyright 2016 Doug Eisele; used by permission.

domain: hobby


text:
Once, in Thessaly, there was a poet called Simonides. He was commissioned to appear at a banquet, given by a man called Scopas, and recite a lyric in praise of his host. Poets have strange vagaries, and in his lyric Simonides incorporated verses in praise of Castor and Pollux, the Heavenly Twins. Scopas was sulky, and said he would pay only half the fee: ‘As for the rest, get it from the Twins.’
A little later, a servant came into the hall. He whispered to Simonides; there were two young men outside, asking for him by name.
He rose and left the banqueting hall. He looked around for the two young men, but he could see no one.
As he turned back, to go and finish his dinner, he heard a terrible noise, of stone splitting and crumbling. He heard the cries of the dying, as the roof of the hall collapsed. Of all the diners, he was the only one left alive.
The bodies were so broken and disfigured that the relatives of the dead could not identify them. But Simonides was a remarkable man. Whatever he saw was imprinted on his mind. He led each of the relatives through the ruins; and pointing to the crushed remains, he said, there is your man. In linking the dead to their names, he worked from the seating plan in his head.
It is Cicero who tells us this story. He tells us how, on that day, Simonides invented the art of memory. He remembered the names, the faces, some sour and bloated, some blithe, some bored. He remembered exactly where everyone was sitting, at the moment the roof fell in.

domain: literature


OUR OPINION: After 51 years, Cuba's leadership sticks to dictatorial
As Cubans end 51 years of living under the Castro brothers' rule, the
regime continues to crack down on bloggers, artists, dissidents and
others who dare question the communist dictatorship.
Sometimes it can seem that little will ever change. But it's clear that
a new generation of Cubans raised on the government's anti-U.S.
propaganda aren't buying it.
It's clear, too, that efforts in Congress to drop the U.S. travel ban on
Cuba have stalled, and for good reason. Even those who have tried to
work with Fidel and Raúl Castro to improve U.S.-Cuba relations are
questioning the Cuban regime's true intentions.
The latest to do so is four-star retired Gen. Barry McCaffrey, former
White House drug czar and SouthCom commander who has called for lifting
the travel ban. He cancelled a Jan. 3-6 trip to the island after Cuban
Foreign Minister Bruno Ródriguez went on the attack, calling President
Obama an ``imperial and arrogant liar.''
The general noted that ``this type of shallow and vitriolic 1960's
public diplomacy makes Cuban leadership appear to be non-serious,
polemical amateurs. President Obama is the most thoughtful and
non-ideological U.S. chief executive that the Cubans have seen in 50
years. . . . [Rodriguez's] speech probably slammed the window shut on
U.S. congressional and administration leaders being willing to support
bringing Cuba back into the community of nations.''
Gen. McCaffrey also pointed out that Raúl Castro ``mentioned Cuba's
recent `war games' to prepare for U.S. invasion. What a laughable
assertion of an external U.S. military threat.''
That old Castro script would be laughable, too, if it hadn't caused so
much suffering on both sides of the Florida Straits. The general
deserves praise for calling it like it is.
Cuba's vitriol - Editorials - MiamiHerald.com (31 December 2009)


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England, Jun23: Andy Roddick's confidence was boosted by winning the Eastbourne Championships on the eve of Wimbledon when he beat defending champion Andreas Seppi 6-3, 6-2 in the final on Saturday.
Tamira Paszek of Austria fought off five match points to defeat fifth-seeded Angelique Kerber of Germany 5-7, 6-3, 7-5 in the women's final.
Roddick entered the event as a wild card after losing his opening match at Queen's Club last week, a defeat that stretched his personal losing streak to six matches dating to mid-March.
It's his 31st career title, ending a 16-month drought.
He looked brisk and business-like against the third-seeded Italian, speeding to a 5-1 lead in the opening set. He was equally dominant in the second set, often forcing his opponent into errors.
After breaking to lead 2-1 he held off a break point and then broke again at love to lead 4-1. Three games later he was a champion again, two days before the start of Wimbledon, where he's been a finalist three times.
Paszek claimed her first title since she won Quebec City late in 2010, and her victory comes after she won just two matches this year with 11 first-round defeats.
The unseeded Austrian battled back from a set and 4-0 down against defending champion Marion Bartoli in the semifinals, and she trailed Kerber 4-2 in the final set of their 2-hour, 45-minute final.
Kerber, who was chasing her third title of the year after winning the Paris Indoor and Copenhagen events, made a blistering start to the match, holding three break points for a 4-0 lead.
Paszek held off that threat and went on to level at 3-3 before Kerber broke again for the set.
Showing greater enthusiasm for battle than her opponent in the second set, Paszek leveled the match by breaking serve twice to set up a tense finale.
Kerber broke serve to lead the third set 4-2 and went on to hold five match points on Paszek's serve at 5-3.
The Austrian fought off the challenge but after slipping during the game she needed her right ankle strapped before continuing play.
Kerber then failed to serve out the match at 5-4, and after Paszek held off a break point at 5-5 she clinched victory on her own third match point by breaking Kerber's serve.
“I don't know what kept me going, how I kept going,” said Paszek, who faces former world No. 1 Caroline Wozniacki in her opening match at Wimbledon next week. “I was dead tired in the third set. I could hardly move. I just gave all I had left, and it just was enough.”
Kerber was disappointed at the result but satisfied with her week of preparation for Wimbledon.
“She was playing very well in important moments and also when I had the match points. So actually I couldn't do anything,” Kerber said.
“Yeah, she won the match, and she played very well today. But I had a lot of great matches, and I won also some good matches here, so now I'm ready for the next week in Wimbledon.”
Roddick was thrilled with his week in the genteel atmosphere of the English south coast resort.
“Yeah, it's been great,” Roddick said. “You know, it's everything I could have asked for. I feel like I can come here and get my work in. The facility has been great. The courts have been great. There's plenty of practice courts. The community really seems to support this event.
“You know, you're not dealing with the hustle and bustle of a massive city. I think before a major, that's nice. You can kind of come down here under the radar and get my work done and really have a positive week. So it was a really good opportunity for me.”


text:
Search America's historic newspaper pages from 1789-1943 or use the U.S. Newspaper Directory to find information about American newspapers published between 1690-present. Chronicling America is sponsored jointly by the National Endowment for the Humanities external link and the Library of Congress. Learn more
About The Mackinaw witness. (Mackinaw City, Mich.) 1901-1???
Mackinaw City, Mich. (1901-1???)
The Mackinaw witness. : (Mackinaw City, Mich.) 1901-1???
- Place of publication:
- Mackinaw City, Mich.
- Geographic coverage:
| View more titles from this:
- Rev. James Thompson
- Dates of publication:
<June 4, 1892>-
- Cheboygan County (Mich.)--Newspapers.
- Mackinaw City (Mich.)--Newspapers.
- Michigan--Cheboygan County.--fast--(OCoLC)fst01214772
- Michigan--Mackinaw City.--fast--(OCoLC)fst01251508
- Description based on: Vol. 1, no. 12 (Feb. 1892).
- Issues also called: <Vol. 1, no. 12 (Feb. 1892>- ; <v. 1, no. 6 (June 4, 1892)>-
- sn 86086620
View complete holdings information

domain: library


text:
GREGYNOG PRESS. NASH, Paul & FISHER, George. ~ Shaw Gives Himself Away. An Autobiographical Miscellany.
One of 300 copies, this no. 120. Printed on Arnold green tinted handmade paper with wood engraved portrait of Shaw by John Farleigh. 8vo., in a binding designed by Paul Nash of original dark green oasis morcoco, signed Gregynog Bindery and Paul Nash on lower turn-in, with inlaid designs in niger morocco based on Shaw’s initials. A extremely good, bright copy with only a couple of small marks, very mild fading to the niger on the spine and the usual slight offset from the turn-ins to the free endpapers.
The book contains extracts and short pieces by Shaw, specially edited with some revisions by Shaw for this edition.


text:
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Free templates available for Elementor Pro as well as Elementor. You can download and browse the different styles that can aid you in designing your website effortlessly.
The open nature of the software makes it highly customizable. It is easy to add blocks or modify existing ones.
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it could damage the theme. This problem is easily avoided by downloading Elementor widgets from different sources and installing them within the Elementor WordPress themes builder. These widgets can be used to complement the theme and provide your website a fresher look.
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domain: design


text:
Inside my Book of Memories,
From nearly 50 years ago...
An image of Mama's old Singer,
As she sat sewing our clothes.
The treddle would clank, the bobbin would whirr
The needle tapped-out its own rapid song:
One thing was certain - tablecloth or curtain -
Something stout, came about, before long!
Such a Mystery! that old black Singer
To one, quite as curious as I:
The 'look, but don't touch', seemed often too much
For this little 6-year-old's mind!
Mama sat there for hours
Bent over her "haute couture";
Her hands fed the cloth into its fate,
While her foot played the drums, on the floor!
Of all the grand magnificence, a la fabrique!
Mama had composed on that Ancient Machine,
Was there never-so-clever, or sweet, an endeavor,
As three green aprons - with pink apron strings!
No garments so priceless, had ever resulted
From the impeccable cunning of my mother...
Until this "one-for-all" - one for mother, daughter, doll -
And nothing...for my brothers!
Nosirreebub! That day was just for me -
A day I'll never forget...
Though I truthfully cannot remember,
If I laughed out loud ... or wept.
For years, I held onto my doll and those two aprons
Until...I suppose I simply passed them on...
Now, I just whisper a prayer,
thankful both these are still there
The precious Memory...and The precious Mom!
==========HAPPY 77TH BIRTHDAY, MAMA==========
Your Loving Daughter ~ Rhonda
C.2006 Rhonda S. Galizia
International Copyright All Rights Reserved By Law.
*In March of 2006 I learned I was a Contest Winner and "Pink Apron Strings" was published in Xulon Press' anthology "Memories of Mother", which was realeased to 25.000 stores in May of 2007, just in time for Mother's Day, so I gave Mama a copy and she was delighted,to say the least - for now, she feels immortalized for the generations to come!


Government forges ahead with changes to licensing regime
December 13th, 2010 by Louise Humphreys
Posted In: Licensing
Following consultation (see earlier post on this topic), the Police Reform and Social Responsibility Bill currently before Parliament clearly indicates the government's intention to press ahead with the introduction of late night levies whilst at the same time significantly widening of the scope of who can comment on licensing applications and a reducing the evidential burden on authorities.
The main provisions of the Bill relevant to the licensing regime include:
- Greater powers for licensing authorities to remove or refuse licences by enabling them to fulfil the same functions as existing responsible authorities and to communities to make representations in relation to licensing decisions or call for a review of licensed premises.
- Removal of the test of 'vicinity' from the 2003 Licensing Act. Everyone - not just those living close to premises - will have the option of commenting on licensing applications, so long as the representations relate to the licensing objectives and are not frivolous or vexatious
- A doubling in the maximum fine for premises which persistently sell alcohol to children to £20,000. The period of suspensions which can be imposed on such premises will be increased
- A reduction in the evidential burden on licensing authorities and the police when making decisions under the 2003 Licensing Act
- Greater flexibility for licensing authorities in making early morning restriction orders. "This means they will be able to make such orders for the whole, or part, of their areas for a period of any duration between midnight and 6 am, and will be able to impose different restrictions on different days"
- Greater flexibility in relation to the scrutiny and utility of temporary event notices. The police and local authorities exercising environmental health functions will be able to object to such a notice on the basis of all the licensing objectives in the 2003 Licensing Act. Licensing authorities will be able to impose conditions on a temporary event notice in limited circumstances
- The addition of Primary Care Trusts or Local Health Boards in Wales as responsible authorities. This means licensing authorities must consult with them before determining or revising its statement of licensing policy. It is the first time these bodies will have had a say in licensing processes
- Licensing authorities will be able to suspend a premises licence or club premises certificate for non-payment of an annual fee
- Powers for councils to charge premises that supply alcohol as part of the late night economy a levy to pay for extra policing. Licensing authorities will be able to impose the levy on such premises for a period of any duration between midnight and 6 am. Some premises may be given an exemption or discount. At least 70% of the funds generated by the levy will be paid to the police and crime commissioner. The levy will also fund bodies that operate measure to address the effect of alcohol related crime and disorder.
- Scrapping of alcohol disorder zones
- A commitment to review the mandatory code within 12 months of its introduction to assess its impact and any unnecessary burdens on business.
However, the government has decided - following the consultation - against introducing earlier proposals to change the appeals process. It has not introduced a ban on below cost sales yet either.


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Computer animation is the speedy display screen of a collection of photos of 2-D artwork in order to produce an impression of movement. Among the most usual means of offering computer animation is a motion picture or video clip program, although a number of other forms of presenting computer animation additionally exist. Due to the extremely enjoyable worth it has, animation has been used in films as it has the capability to attract an audience of various age, from 8 to 80.
The use of animation in movies most likely started in the year 1890. J. Stuart Blackton was the first man that put computer animation in his movie titled ‘Humorous Phases of Funny Deals With’. The film featured a cartoonist attracting faces on a chalkboard, as well as the faces actually coming to life. Afterwards lots of filmmakers and producers began making use of different animations in their films that evidently brought life to their photos.
Soon, the stage came where the audience slowly got the opportunity to see films or movies where every character was computer animated. Those are complete fledged cartoon animations. If we take a look at the list of the block bluster films, we will certainly be shocked to locate that computer animation motion pictures are equally contributing to this checklist.
Films like The Lion King, Shrek, Monsters, Toy Tale, Aladdin, Snow White and the Seven Dwarfs, Glacial Period, Tarzan, An Insect’s Life, etc are thought about as the leading 10 animated movies both by the customers and doubters. Giant home entertainment business like Walt Disney, Pixar, Fox Entertainment, Dream Works, etc have actually spent numerous bucks behind these cartoon animations as well as their revenue was also approximately the assumption.
The Lion King produced by Walt Disney Feature Production is one of the most believed provoking cartoon animations. It was initially titled the King of the Jungle. In order to accomplish perfection the animators who worked with this film studied the activities and also the activities of reality pets also. In fact the filmmakers were such perfectionists that they went to Kenya to study the all-natural environment that is utilized as a history in the film. The movie included green grass, the smoke from the fire, and also the falls, all provided in excellent computer animation. The personalities were constructed utilizing 3D computer system programmes that looked excellent.
Shrek is based upon a fairytale picture manga generated by Desire Functions. Though the movie is indicated for youngsters, the style has likewise attracted adults. The plot of the flick is easy and also amusing. As a matter of fact this film became so prominent that computer games were made on Shrek.
Aladdin, the animated film produced by Walt Disney Attribute Animation, is based on the story of Aladdin and the magic lamp of Arabian Nights. The personality of Aladdin was attracted by keeping in mind the faces of different Hollywood heroes as well as at the end it was decided that he would appear like Tom Cruise. Special computer system animations were utilized to develop some scenes of the film. Some such instances are the complete sight of the royal residence, the magic carpeting, the breaking up of the cave, etc.
Snow White and the 7 Dwarfs, produced in 1937 by Walt Disney, is thought about as one of the initial commercially successful animation films. The movie is a leader in lots of ways. It took 3 years to make this film since back then the animations were not developed. They used lots of techniques that remained in the primary stage of growth during that time. They used animations to develop rainfall, lightning, water, reflections, shines, magic, and so on.
Plaything Story, created by Pixar Animation Studio is a cartoon animation that is totally created on computer system. The tale revolves around the toys of a 9 year old child as well as the tale of the film is distinguished the toy’s viewpoint.
A Bug’s Life, once again generated by Pixar Animation Studio and also released in 1998, informs the tale of ants which believe that they are warrior pests and they have the courage to fight with the greedy grasshoppers. John Lasseter routed it. The tale is based on the renowned Aesop’s fable of the Ant as well as the Insect.
One can see that most of the computer animation flicks are meant for youngsters. Yet seniors likewise just as delight in these because these computer animation motion pictures have different layers of significance. With the fast developments in various animated software, one can certainly expect a solid future in generating computer animation movies.


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The proposal for the State Street Parking Garage in Sarasota may have created a controversy over costs, but the design has created a storm of opposition — at least among my 1,300 Facebook friends.
After the Herald-Tribune ran an article about the garage a few days ago, I snapped a photo of the rendering in the newspaper and posted on Facebook: “Proposed State Street Parking Garage, beside being too expensive, has ridiculous architecture right out of 1880. Why not be progressive, a la the Palm Avenue Parking Garage?”
That post drew 25 “likes” and 54 comments. A related post about the Lincoln Road parking garage by Jacques Herzog and Pierre de Meuron in Miami Beach drew a similar torrent of responses.
And not just from architects.
“They have an opportunity to build something great,” said mortgage broker Mike Rahn, “instead of something that looks like a sweat shop textile building.”
“This design should be scrapped,” wrote Realtor Albert Wooster.
“The ornamental detailing of these pseudo-old buildings adds a lot of costs,” wrote general contractor Josh Wynne. “Honesty in detailing, rather than ornament for ornament’s sake, is a better approach to saving cost and it yields a more genuine building.”
Said local architect Leonardo Lunardi, “The members of the Sarasota school of architecture were innovators with an aggressive desire to reach into the future. Using the architectural philosophy that they laid out is great, but going back and emulating their designs goes against the very principles that generated them. A philosophy cannot be emulated, unlike a style.”
I think Jonathan Parks’ Palm Avenue Parking Garage follows such progressive thinking.
“The Palm Avenue garage is a treat and a delight,” said magazine writer Ruth Lando. “Why not follow that successful example?”
The majority of comments were along this line. One supporter of the proposed garage said, “It’s a matter of taste. I’ll take the 1800s look over the ‘progressive’ look any day.”
This discussion went on and on, and ended with me defending the Herald-Tribune building’s architecture. Which got me to thinking, maybe it is time to share my core architectural values. Some people might be confused, as I have written many stories about modern architecture, yet live in a 1930 Old Florida bungalow.
Originality, not imitation
No matter the “style” (architects hate that word, preferring language) of design, architecture should use original, or at least inspired, thinking to solve the client’s needs. It is not against the law to copy the Taj Mahal, but it would not be good architecture to do so.
Attention to detail
It is more expense and work to quality-control every aspect of a building, from the cut of the baseboards to the fit of drywall to door frame, but it makes a huge aesthetic impact.
Honest use of materials
Don’t glue foam plastic corbels and vinyl details to a house and expect to gain a lot of respect among good builders and architects. The same can be said when covering construction faults with trim.
No one sets out to build an ugly building. But they can become that way through neglect. The appeal of the most nondescript ranch house can be restored not with remodeling, but with repairs, maintenance and relandscaping. If the house can be made to look as it did on Day One, the owner will be proud and happy.
Honor the past, build to the future
Every city worth its salt has an architectural heritage. While it must be respected, it should not be copied. Contemporary work should follow the work of past architects by respecting context, quality and attention to detail.
Preserve our history
The architectural trends of the day certainly do not dictate that we cast aside our historical treasures. They must be maintained and preserved. If they are in the way, move them.
Plan over style
Urban planning, and site planning, is more important than architecture. The most appealing places have plans that welcome human interaction. Almost any architectural style will work on a good plan. Aqua in Miami Beach is a perfect example: New Urbanist plan by Andres Duany; modernist architecture. Seaside is another: Plan by Duany, traditionally-inspired architecture.
When architects from other areas are hired by local developers, many in the community groan and complain. “Hire local!” they say. Why? Pierre Charles L’Enfant was not from Washington, D.C., which he planned. Frank Gehry is not from Bilbao, Spain, where he did the Guggenheim Museum in the 1990s. Thomas Reed Martin was not local when Bertha Palmer brought him here from Chicago. John Ringling hired a New Yorker, Dwight James Baum, to do Ca d’Zan. Cross-pollination is good.


text:
The next 3D mainline installment in the long-running Sonic the Hedgehog series finally receives a gameplay reveal.
After a year of cinematic teaser trailers, Sega via the official Sonic the Hedgehog Youtube channel has finally showed us what kind of gameplay we can expect for this new, open-world game in the series.
It was stated that IGN will have exclusive coverage of the game for the month of June. They revealed even more gameplay:
Sonic Frontiers is set to release for Switch and other platforms this holiday.
Dave’s first Nintendo platform was the GameCube when he was age 7; however, he was introduced to Nintendo through Duck Hunt on NES.

domain: game


text:
Retailers in the Republic are seeking significant support from the Irish Government in paying commercial rent ahead of Wednesday when hundreds of millions of euro are due to be paid for quarter two.
In a circular sent to around 200 well-known retailers, Retail Excellence warned that many shops will take up to three years to recover from the current crisis.
It said a significant proportion of retailers will not be in a position to pay their quarter two 2020 rent bill.
"They are scrambling to negotiate alternation of terms, but ultimately they are simply buying time before the inevitable happens," said the circular.
This would have a very significant impact on large commercial landlords, which were hit by a decision by Penneys - which trades in the UK as Primark - to suspend rents on its Irish stores during this period.
Retail Excellence is suggesting that the Government pay 60% of rents of closed or distressed retailers for the next three months, landlords pay 20% and tenants 20%.
It is understood that such a plan would cost the Irish Government €330m for the three-month period. It is based on an approach being taken in Italy.
The circular said that a number of international retailers are reviewing their continued presence in Ireland and other markets.
It added that support from parent companies has not been granted due to the global nature of the crisis.
Significant legal battles between landlords and tenants over non-payment of commercial rent are being predicted. "And ultimately we will all lose - both tenant and landlord," it said.
The circular also said that when shops reopen in a few months, the economic outlook will remain bleak.
"Trading revenues will be like-for-like down at best 40-60% for the first six months of trading," it said.
"For some sectors of Irish retail, it will take three or more years to recover.
"By way of example, visitor-facing retail won't recover until at best 2023."
Primark was one of the first major retailers in the UK it announce it was closing its stores, ahead of the UK and Irish governments' announcements that all non-essential shops should shut.

domain: politics


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iirc, placing sand does not trigger a physics event to be cancelled. (either that or it can't be cancelled) i think what you'd have to do is, in addition to cancelling physics events, cancel placing sand/gravel, and then replace that with a settype (material, false);. 3. level 2. wizjany.
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commercial gravel mining. the department permits about 200 in-stream sites, annually. numerous commercial mining operators across the state excavate sand and gravel deposits, commonly known as gravel bars, as a source of aggregate material. questions about permitting should be directed to the departments land reclamation program at 573-751-4041.
most pumps used for the dredging of sand and gravel deposits are centrifugal. these lift the material, along with a percentage of water, into a rotating impeller. this applies a centrifugal force to the mixture, which is pushed out of the pump and into the discharge pipe at right angles to the direction of suction.
gravel is a block that is affected by gravity. gravel is generated in disks on beaches, near rivers and small pools of water; in gravelly mountains biomes covering most of the surface; and underwater covering the bottom of normal, cold, and frozen ocean biomes, as well as their deep variants. gravel can generate in the overworld in the form of blobs. gravel attempts to generate 8 times per
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With nine different corrosion-resistant bits, the EMT 9 Tool has all the tools you need for almost any repair. - Forged aluminum side plates. - Forged steel bits are nickel plated for corrosion resistance. - 2, 2.5, 3, 4, 5, 6, and 8mm hex bits - T25 Torx and Phillips head screwdriver bits.
Attach this handy multi-tool to your Specialized SWAT-equipped water bottle cage (sold separately) and hit the trails secure in the knowledge that your tools are close at hand. The tool features hardened steel bits with an anti-rust coating and the plastic tool cradle holds securely and rattle-free thanks to the two attachment points.
Specialized's MTB XC Box integrates with any SWAT compatible Specialized water bottle cage and SWAT-prepped mountain bike to hold all of the gear need to make fast trailside flat repairs. - Fits one Turbo 29er innertube, SWAT tire lever, CO2 twist head, and 25g CO2 cartridge (not included).
Before you find yourself in a bind, it's important to plan on how you'll get out of one. Well, look no further than our SWAT Conceal Carry MTB Tool. It stashes an emergency multi-tool and chain breaker inside the steerer tube of a suspension fork for easy transport and instant access. On the tool, you'll find a wide array of Allen keys and a Torx wrench, so you'll be able to get out of any trail-side jam. - Stores a multi-tool and chain breaker in the steerer tube of most modern suspension forks with alloy steerer tubes. - Quick-action top pivots away to release spring loaded multi-tool. - Features hardened CRV steel bits with anti-rust coating and forged alloy frame. - Includes 3, 4, 5, 6, and 8mm Allen keys and a T25 Torx.
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If lightweight, minimalist, and wallet-friendly are at the top of your tool priority list, look no further than the EMT 6 Tool. With six different bits, you'll have plenty to manage common roadside mechanicals. - Forged steel bits are nickel plated for corrosion resistance. - 3, 4, 5, and 6mm hex bits - T25 Torx and Phillips head screwdriver bits.
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text:
Hrishita: Controversially yours!
Dancing has taken her places, literally. A demure Gujarati girl, Hrishita Bhatt was taking dancing lessons from choreographer Shiamak Davar, unaware that she had charmed some people from the advertising fraternity. Her cute smile got her the opportunity to feature in an ad for Liril soap, and things took off.
There were music videos and more advertisements, followed by a rather natural move to the big screen. First-time director Gurudev Bhalla cast her opposite Abhishek Bachchan in Shararat, after which she starred as Shah Rukh Khan's wife in his magnum opus Asoka.
We caught up with Bhatt to talk about what happens next.
Text: Priyanka Jain


text:
|Publication number||US4328208 A|
|Application number||US 06/265,559|
|Publication date||May 4, 1982|
|Filing date||May 20, 1981|
|Priority date||May 20, 1981|
|Publication number||06265559, 265559, US 4328208 A, US 4328208A, US-A-4328208, US4328208 A, US4328208A|
|Inventors||Ildus A. Kurbanov, Rasikh K. Jusupov, Roman V. Borovik, Talgat G. Gabdulkhaev, Ilmira A. Kurbanova|
|Original Assignee||Kurbanov Ildus A, Jusupov Rasikh K, Borovik Roman V, Gabdulkhaev Talgat G, Kurbanova Ilmira A|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (15), Non-Patent Citations (18), Referenced by (4), Classifications (15), Legal Events (4)|
|External Links: USPTO, USPTO Assignment, Espacenet|
______________________________________antigenous liquid of inactivated suspen-sion of cells of yolk sacks of chickenembryos infected with chlamydousinfectant 8 to 10aqueous solution of a mixture of tris-hydroxymethylaminomethane andtetramethylethylene diamine in a weightratio of 15:1 to 16:1 respectively 1 to 2aqueous solution of a mixture ofacrylamide and methylbisacrylamide in aweight ratio of 37:1 to 38:1 respectively 3 to 41.4% aqueous solution of ammoniumpersulphate 1 to 225% aqueous solution of glutaricaldehyde 0.026 to 0.028physiological solution or phosphatein an amount equal tobuffer solution the total amount of the above components.______________________________________
The present invention relates to veterinary biological preparations and, more specifically, it relates to a vaccine against chlamydous infections of farm animals and can be useful for the specific prophylaxis of chlamydous infections of farm animals and for the preparation, with these infections, of the immune serum.
Known in the art are vaccine against chlamydous abortions of sheep consisting of inactivated suspensions of yolk sacks of chicken embryos infected with chlamydiosis infectant with the addition of an oily adjuvant (cf. J. Storz Chlamydia and Chlamydia-Induced Diseases, 1971, p. 270-279).
A disadvantage of the prior art vaccines resides in a weak immunogeneity thereof, insufficiently restrained immunity, multiple vaccination of animals, separation of the oily adjuvant from the immunogenic mass thickening of the oily adjuvant at low temperatures (+4° C.), causing the necessity of preheating the vaccine for the passage thereof through the injection needle, and restricted field of application of the vaccines to only one animal species.
It is an object of the present invention to provide a vaccine against chlamydous infections of all species of farm animals which would possess a prolonged effect and a high immunogenic activity.
This object is accomplished by that the vaccine against chlamydous infections of farm animals containing and antigenous liquid of an inactivated suspension of cells of yolk sacks of chicken embryos infected with a chlamydia infectant in a physiologcial solution or a phosphate-buffer solution and an adjuvant, according to the present invention, contains as the adjuvant an aqueous solution of a mixture of tris-hydroxymethylaminometane and tetramethylethylene diamine, an aqueous solution of a mixture of acrylamide and methylbisacrylamide, an aqueous solution of ammonium persulphate and an aqueous solution of glutaric aldehyde, the components being present in the following proportions, ml:
______________________________________antigenous liquid of an inactivated suspensionof cells of yolk sacks of checken embryos in-fected with chlamydia infectant 8 to 10aqueous solution of a mixture of tris-hydroxymethylaminomethane and tetramethyl-ethylene diamine in a weight ratio offrom 15:1 to 16:1 respectively 1 to 2aqueous solution of a mixture of acrylamideand methylbisacrylamide in a weight ratioof 37:1 to 38:1 respectively 3 to 41.4% aqueous solution of ammoniumpersulphate 1 to 225% aqueous solution of glutaric aldehyde 0.026 to 0.038physiological solution or phosphatebuffer solution in an amount equal to the total amount of the above- specified components.______________________________________
Inactivation of the suspension of cells of yolk sacks of chicken embryos infected with chlamydia infectant can be effected by means of conventional inactivators, namely merthiolate.
As the antigenous liquid the vaccine according to the present invention preferably contains a suspension of cells of yolk sacks of chicken embryos infected with chlamydia infectant and inactivated with merthiolate to the content thereof in the suspension of 0.05% by weight and formaldehyde to the content thereof in the suspension of 0.15% by weight. The incorporation, into the vaccine composition, of a new adjuvant makes it possible to effect polymerization of protein components of chlamydia shells while retaining their antigenous activity. The protein polymerization lowers its solubility simultaneously increasing antigeneous properties of protein structures of chlamydiae. One of the most important conditions of enahncing the immunogeneous properties of antigens is their corpusculation, i.e. creation of such a macromolecular structure of the antigen which would be suitable for interaction with macrophagous blood form elements. Insoluble aggregated antigens possess higher activity as compared to low-molecular soluble antigens. In the case of corpusculation of the antigen, its transformation to the aggregated state capable of withstanding enzymatic cleavage of tissues with enzymes is obtained by inclusion of chlamydiae into a synthetic gel of polyacrylamide. At the same time, preconditions are created for the formation of an antigenous depot in the organism. All this imparts a high immunogenic activity of a prolonged effect to the vaccine according to the present invention.
The vaccine of the present invention is produced in the following manner.
A suspension of yolk sacks of chicken embryos infected with chlamydia infectant is prepared. As the infectant use can be made of any kind of chlamydous infections.
The yolk scks of chicken embryos infected with chlamydia infectant are then subjected to the determination of the infectant titre by infection into yolk of 6-7 days' age chicken embryos. A high immunogeneity of the vaccine prepared from infected yolk sacks of chicken embryos with the chlamydia titre ELD50 (embryo of lethan doses) of 106.5 to 107.0 has been proved experimentally.
Yolk sacks of chicken embryos are infected in a dose of 0.25 to 0.3 ml with the infectant titre of from 106.5 to 107.0 ELD50 per each embryo. The suspension is prepared using a sterile 0.2 M phosphate buffer with a pH of 7.6-7.8, physiological solution or Hanks' buffer solution.
The resulting suspension is settled at the temperature of 4° C., the liquid over the residue is removed by suction and transferred into a sterile vessel, whereinto the inactivator is added. As the inactivator use can be made of a solution of merthiolate (1:5,000) to the final concentration of merthiolate in the suspension of 0.1% by weight or merthiolate in combination with formaldehyde to the final concentration of merthiolate of 0.05% and that of formaldehyde of 0.15% by weight in the suspension. The resulting mixture is kept, for inactivation of the infectant, in a thermostat at the temperature of 37° C. for 10-12 hours or in a refrigerator at a temperature of from 4° to 6° C. for 16 to 18 hours while periodically shaking the mixture.
Thereafter the adjuvant is added to the inactivated suspension. To this end, the following solutions are preliminary prepared: the first solution "A" comprises a mixture of tris-hydroxymethylaminomethane with tetramethylethylene diamine taken in a weight ratio of 15:1 to 16:1 respectively dissolved in sterile distilled water.
The second solution "C" comprises a mixture of acrylamide and methylbisacrylamide taken in a weight ratio of 37:1 to 38:1 respectively. The solutions "A" and "C" are stable for one month when stored at the temperature of 5° C.
These solutions are successively introduced into the inactivated suspension, then added with a 1.4% aqueous solution of ammonium persulphate and 25% solution of glutaric aldehyde.
The mixture is thoroughly intermized and kept in a refrigerator at a temperature of from 4° to 6° C. for 16 to 18 hours or in a thermostat at the temperature of 37° C. for 2-3 hours. During this period the vaccine mass is polymerized in the polyacrylamide gel. The resulting polymerized vaccine mass in the polyacrylamide gel is homogenized in homogenizers or colloidal mills with the equal volume of a sterile physiological solution (pH=7.2 to 7.4) or Hank's solution to a slurry-like consistence capable of passing through an injection needle. The thus-prepared vaccine is packed into flasks under sterile conditions.
The vaccine according to the present invention has been tested on various species of farm animals.
For prophylactic purposes, it is advisable that the vaccine according to the present invention be administered to farm animals once intramuscularly or hypodermally: to cattle in the dose of 5 ml, to small cattle--in a dose of 1-2 ml.
For a better understanding of the present invention, some specific examples illustrating tests of the vaccine and the method for preparing same according to the present invention are given hereinbelow.
There are prepared 100 ml of a 20% suspension of yolk sacks of chicken embryos infected with the infectant Chlamydiae, strain "250", in sterile Hanks' buffer solution. The resulting suspension is settled at the temperature of 4° C. for 2 hours. The liquid over the residue is sucked by a sterile pipette and transferred into a sterile flask. The resulting antigenous liquid is imspected for the absence of foreign microflora by inoculation onto Marten's broth, followed by residence in a thermostat at the temperature of 37° C. for 6 days. The broth shall be clear and give no rise to foreign microflora. Then into the antigenous liquid over the residue in the volume of 80 ml an aqueous solution of merthiolate is added to its final concentration of 0.05% by weight and formaldehyde to its concentration of 0.15% by weight in the antigenous liquid.
The mixture is maintained in a thermostat at the temperature of 37° C. for a period of from 10 to 14 hours. Then the adjuvant is introduced into the mixture.
To this end, the following solutions are prepared: Solution "A": to 48 ml of a 1 N solution of hydrochloric acid there are added 36.3 g of tris-hydroxymethylaminomethane, 0.23 ml of tetramethylethylene diamine and brought to 100 ml with sterile distilled water with pH of 8.9. Solution "C": 30 g of acrylamide and 0.8 g of methenebisacrylamide are distilled in sterile distilled water to 100 ml. Solutions "A" and "C" are stable for one month, provided that they are stored at the temperature of 5° C.
Then to 80 ml of the antigenous liquod there are successively added 10 ml of solution "A" and 30 ml of solution "C", 10 ml of 1.4% solution of ammonium persulphate and 25% solution of glutaric aldehyde to the final concentration thereof of 0.05% by weight in the antigenous liquid. The mixture after thorough stirring is placed into a thermostat at the temperature of 37° C. for 2-3 hours. The resulting polymerized vaccine mass in the polyacrylamide gel in the amount of 130 ml is homogenized with the equal volume of the Hanks' solution to a slurry-like consistence capable of passing through an injection needle. The resulting vaccine is tested for toxicity and immunogeneity. The testing of toxicity and immunogeneity of the vaccine according to the present invention is effected on white mice or pregnant guinea pigs by way of intraperitoneal administration of the vaccine to white mice (weighing 10-15 g) in the amount of 0.25 ml, to pregnant guinea pigs--in the amount of 0.5 ml, followed by intraperitoneal infection of these animals with an infectant out of the group of chlamydiae, strain "250". One third portion (1/3) of the animals are not vaccinized. The control non-vaccinized animals (white mice) have died, while pregnant guinea pigs have aborted. The vaccinized white mice survive, while vaccinized pregnant guinea pigs give healthy brood.
There are prepared 120 ml of a 40% suspension of yolk sacks of chicken embryo infected with the infectant Chlamydiae, strain 250, in a sterile physiological solution with pH of 7.6-7.8. The resulting suspension is settled at the temperature of 4° C. for 2 hours. The liquid over the residue is sucked by means of a sterile pipette and transferred into a sterile flask. The control for the absence of foreign microflora is effected following the procedure described in the foregoing Example 1. Then into the overresidue antigenous liquid in the volume of 100 ml an aqueous solution of merthiolate is added to the final concentration of 0.1% by weight. The mixture is kept in a refrigerator at a temperature of from 4° to 6° C. for 16 to 18 hours. Then the adjuvant is added to the mixture. Solutions "A" and "C" are preliminary prepared in a manner similar to that described in Example 1. Then to 100 ml of the antigenous liquid there are successively added 20 ml of solution "A", 40 ml of solution "C", 20 ml of 1.4% solution of ammonium persulphate and 25% solution of glutaric aldehyde to the final concentration thereof in the antigenous liquid of 0.05% by weight. The mixture after thorough stirring is kept in a refrigerator at a temperature of 4° to 6° C. for 16 to 18 hours. The resulting polymerized vaccine mass in the polyacrylamide gel in the amount of 180 ml is homogenized with the equal volume of physiological solution to a slurry-like consistence capable of passing through an injection needle. The resulting vaccine is tested for toxicity and immunogeneity in a manner similar to that described in Example 1 hereinbefore.
The vaccine of the present invention has been tested on bulls, sheep and pregnant heifers. A portion of the nonvaccinized cows has been used for control. According to the literature data and our own researches the infectant of abortion in cows from the group of chlamydiae is also pathogenic for sheep.
Both vaccines have been hypodermally injected to bulls, pregnant heifers in the dose of 5 ml and to sheep in the dose of 2 ml. The assessment of the vaccine efficiency has been made according to clinical and immunological characteristics and the results of the control infection. Blood for the preparation of serum has been taken twice before the vaccination and on the 5th, 11th day after the vaccination and then on the 3, 8, 12, 19th day after the infection. The vaccinized bulls, sheep and pregnant heifers have been infected with a live infectant of chlamydiae, strain 250.
No clinical symptoms have been noticed in the vaccinized animals. Serological studies in the reaction of complement binding, the complement-binding antibodies have been revealed in vaccinized sheep, bulls and pregnant heifers already on the 5th and 11th day in a titre of from 1:16 to 1:128. The control infection of the non-vaccinized animals (sheep, bulls, pregnant heifers) is accompanied by a total suppression of the animals, flabbiness, hypodynamics, reduced appetite and increased general body temperature to 41° C.-41.5° C. Within one week all the above-indicated pathological changes passed. The pregnant non-vaccinized heifers after the infection have aborted or brough before time weak, nonvital calves which died within three days after calving. In all of them the delay in afterbirth emission.
In the vaccinized bulls, sheep and pregnant heifers after the control infection no pathology in the general condition has been noticed. The pregnant heifers have calved in time and brought normal well-developed calves.
The vaccine ensures the antigenous activity and creates immunity in the vaccinized animals against the experimental infection.
In a similar manner 4 series of tests have been performed.
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|GB916803A *||Title not available|
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|Citing Patent||Filing date||Publication date||Applicant||Title|
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|U.S. Classification||424/263.1, 424/278.1, 424/823, 424/824|
|International Classification||A61K39/118, A61K39/39|
|Cooperative Classification||A61K2039/55505, A61K2039/55588, A61K2039/55555, Y10S424/823, Y10S424/824, A61K39/39, A61K39/118|
|European Classification||A61K39/39, A61K39/118|
|Oct 25, 1985||FPAY||Fee payment|
Year of fee payment: 4
|Dec 5, 1989||REMI||Maintenance fee reminder mailed|
|May 6, 1990||LAPS||Lapse for failure to pay maintenance fees|
|Jul 17, 1990||FP||Expired due to failure to pay maintenance fee|
Effective date: 19900506


text:
Guinean opposition veteran Jean-Marie Dore (pictured) has been named prime minister of a transition government by the country’s ruling military junta, with union leader Rabiatou Serah Diallo as deputy prime minister, according to junta sources.
REUTERS - Guinea’s military junta has named veteran opposition politician Jean-Marie Dore as prime minister of a transition government charged with restoring civilian rule, a source close to the junta said on Tuesday.
Turmoil in Guinea
- Kenya kills suspects after coastal massacres
- Afrobeat: Guinean singer Sia Tolno proud to be an 'African Woman'
- A train derailment in DR Congo and rice looting in Guinea
- Current Ebola epidemic 'unprecedented', WHO warns
- Guinea's gold rush
- Ebola cases confirmed in Conakry
- Ebola cases confirmed in Guinean capital Conakry
- Death toll from Ugandan ferry sinking tops 100
- Ebola epidemic reaches Guinea capital, UNICEF says
- Guinea confirms deadly fever is Ebola virus
The international community and Guinean opposition parties have demanded elections since Camara’s coup sparked a political crisis which some feared could destabilise a fragile region.
Date created : 2010-01-19


Aug 26, 2012; East Rutherford, NJ, USA; New York Jets cornerback Darrelle Revis (24) during the second half of their game against the Carolina Panthers at MetLife Stadium. The Panthers defeated the Jets 17-12. Mandatory Credit: Ed Mulholland-USA TODAY Sports
TAMPA, Florida (AP) - The Tampa Bay Buccaneers feel they've already had a strong draft.
Landing three-time All-Pro cornerback Darrelle Revis in exchange for the 13th overall pick of the first round not only addressed the team's biggest need, but offers general manager Mark Dominik and coach Greg Schiano some flexibility in the team's approach in later rounds.
The acquisition of Revis from the New York Jets won't necessarily preclude the Bucs from seeking more help for what figures to be a much improved secondary, however it does enhance the prospect of targeting a tight end, change-of-pace running back or maybe even a quarterback before pursuing additional reinforcements for the defense.


text:
in a Sentence
Definition of Empathy
to understand and share the feelings of another
Examples of Empathy in a sentence
Because her parents immigrated to the United States to give her a better life, Maria has empathy for illegal aliens.
Bart has a hard time forming healthy relationships because he lacks empathy for others.
As an expression of her empathy, Pat will often apologize even when she has done nothing wrong.
When questioned about his acts, the killer showed no empathy for his victims or their grieving families.
Because Ginger has a strong sense of empathy, she will be a very effective marriage counselor.
As a parent, I can only feel a great deal of empathy for mothers who lose their children under tragic circumstances.
My boss felt no empathy for our team when we failed to meet our project deadline.
Because Tiffany believes the world revolves around her, she is incapable of feeling empathy for other people.
Since he is a cancer survivor himself, my doctor was able to show me a great deal of empathy during my chemotherapy treatments.
The author invites us to feel empathy with the tragic characters in his novel.
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text:
By Alexandra Brothers / August 25, 2023
After four months, there have still been no leads regarding the homicide that took place in Harbour Grace in April.
Police found the body of 34-year-old Adam Mercer in a burnt-out vehicle on Glover Road on April 11. The death was ruled a homicide the following week, and on April 19, RCMP released a statement saying that police have information leading them to believe the murder was carried out by more than one suspect. The statement also said that police believe there are witnesses who are withholding vital information regarding the murder. At a press conference on April 19, RCMP Cpl. Jolene Garland said that police had identified suspects, but called on the public for more information from witnesses that could aid the investigation. Since then, no new information has been made public.
The Shoreline reached outlast week to the RCMP for further information on the case.
“Our Major Crime Unit, which is leading the investigation, has indicated there are no updates to share at this time,” said the director of strategic communications for the RCMP, Glenda Power. “We continue to encourage anyone having information relevant to this homicide to contact the RCMP at 709-772-5433 or 709-637-4420 if they have not already done so.”


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