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Does a lack of physical activity explain the rheumatoid arthritis lipid profile?
Lipids in Health and Disease volume 16, Article number: 39 (2017)
In rheumatoid arthritis (RA), cardiovascular risk is associated with paradoxical reductions in total cholesterol, low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C). Concentrations of small LDL (LDL-P) and HDL (HDL-P) particles are also reduced with increased inflammation and disease activity in RA patients. Here we sought to identify which measure(s) of inflammation, disease activity and cardiometabolic risk contribute most to the RA-associated lipoprotein profile.
NMR lipoprotein measurements were obtained for individuals with RA (n = 50) and age-, gender-, and body mass index (BMI)-matched controls (n = 39). Groups were compared using 39 matched pairs with 11 additional subjects used in RA only analyses. Among RA patients, relationships were determined for lipoprotein parameters with measures of disease activity, disability, pain, inflammation, body composition, insulin sensitivity and exercise. Percentage of time spent in basal activity (<1 metabolic equivalent) and exercise (≥3 metabolic equivalents) were objectively-determined.
Subjects with RA had fewer total and small LDL-P as well as larger LDL and HDL size (P < 0.05). Among RA patients, pain and disability were associated with fewer small HDL-P (P < 0.05), while interleukin (IL)-6, IL-18, and TNF-α were associated with LDL size (P < 0.05). BMI, waist circumference, abdominal visceral adiposity and insulin resistance were associated with more total and small LDL-P, fewer large HDL-P, and a reduction in HDL size (P < 0.05). Most similar to the RA lipoprotein profile, more basal activity (minimal physical activity) and less exercise time were associated with fewer small LDL-P and total and small HDL-P (P < 0.05).
The RA-associated lipoprotein profile is associated with a lack of physical activity.
As this was a cross-sectional investigation and not an intervention and was performed from 2008–13, this study was not registered in clinicaltrials.gov.
Patients with rheumatoid arthritis (RA), a chronic inflammatory disease, have a 2- to 3-fold increased risk of cardiovascular disease (CVD) [1–4]. This has been attributed to disease-associated chronic inflammation, physical inactivity, increased adiposity, insulin resistance, and altered lipid profiles [5, 6]. Despite the increased CVD risk, RA patients often present with reduced total cholesterol, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C), which is opposite of the lipid profile typically observed in subjects at high risk of CVD [7–9]. Hence, the relationship between high CVD risk and lower cholesterol levels in RA patients has been referred to as the “lipid paradox.” [7–9].
Efforts to better understand the “lipid paradox” have included the measurement of lipoprotein particles via nuclear magnetic resonance spectroscopy (NMR) in patients with RA . Compared to controls, RA patients have fewer small LDL (LDL-P) and small HDL (HDL-P) particles . Moreover, small HDL-P are inversely associated with disease activity and coronary artery calcification in RA patients . In active RA, HDL particles contain pro-inflammatory proteins such as serum amyloid A and fibrinogen which often replace anti-inflammatory and anti-oxidant molecules, which alters their function . All in all, inflammation mediates alterations in HDL particle size and function that may contribute to the increased CVD observed in RA patients . Furthermore, after anti-inflammatory therapy, total cholesterol, LDL-C, HDL-C, HDL-P levels increase . Such increases have been attributed to reduced inflammation and cholesterol ester catabolism leading to an increase in lipoprotein cholesteryl ester levels . While increased cholesterol levels are often associated with increased CVD risk, in the context of chronic inflammatory disease increased circulating cholesterol may be a reflection of the reduced inflammation and an accompanied reduction in CVD risk [13, 14].
Unfortunately, the changes observed in circulating lipids and lipoproteins in RA patients are complex as many factors besides inflammation contribute to the overall picture. For example, there are known alterations in cholesterol and lipoproteins that occur in subjects who are overweight with metabolic syndrome and/or type 2 diabetes. These include reductions in HDL-C, large HDL-P and large LDL-P and an increase in triglycerides, small LDL-P and small HDL-P, while LDL-C levels often remain in the normal range. In contrast, exercise often reverses these changes. High amounts of exercise lead to decreased small LDL-P and total LDL-P and increased large HDL-P, HDL-C as well as HDL and LDL size . Patients with RA are often overweight, especially when regular physical activity is impaired by disease activity and joint damage. Therefore, disease activity, physical activity and metabolic syndrome risk factors such as body mass index (BMI), waist circumference and insulin resistance, may confound the effects of inflammation on cholesterol and lipoprotein parameters in patients with RA.
In a recent study in established and treated RA patients, we found that traditional metabolic risk factors such as excess adiposity played a more prominent role in predicting skeletal muscle insulin sensitivity than systemic inflammation or other disease-related factors. However, we hypothesized that the changes observed in the “lipid paradox” are less related to metabolic syndrome risk factors and more related to lack of physical activity as a result of increased disease activity, pain and inflammation. To test this hypothesis we looked at the associations between NMR lipoprotein parameters and various measures of disease activity, inflammation, body composition, insulin sensitivity and physical activity (basal activity vs. exercise).
Participants and design
The study design and procedures have been previously reported . Briefly, this was a cross-sectional comparison of insulin sensitivity between persons with RA and age- (+/− three years), gender-, race-, and BMI (+/− 3 kg/m2) -matched controls (n = 39 each). An additional 11 subjects with RA without a match were include in RA-only analyses. Persons with RA were either seropositive or had erosions on radiographs, met 1987 American College of Rheumatology criteria for RA , had no medication changes in the last three months, and were using stable doses of prednisone of 5 mg or less per day. Exclusions were known diabetes mellitus or CVD. Five persons with RA and two controls were using HMG CoA reductase inhibitors (statins); findings were not altered substantially when these persons were excluded from analyses. The study was in compliance with the Helsinki Declaration and was approved by the Duke University Medical Center Institutional Review Board (#7701).
Physical examinations and questionnaires assessed anthropometrics, disease activity, pain, and disability . Insulin sensitivity was calculated from glucose and insulin concentrations during a frequently sampled intravenous glucose tolerance test . Fasting concentrations of inflammatory cytokines were measured using ELISAs . Abdominal and thigh adipose depots were measured using abdominal and thigh CT scans. Physical activity was measured using seven days of accelerometry (RT3, Stayhealthy, Inc., Monrovia, CA) [16, 18]. Data were excluded from analyses as follows: nonwear time defined as 90 consecutive minutes of zero activity data; days with less than 10 h of data; participants with less than four (10-h) days. Physical activity analyses included 41 RA participants. Basal activity was defined as less than one metabolic equivalent, the predicted amount of oxygen consumed while sitting at rest . Exercise was defined as the combination of moderate, high, and very high intensity activity or greater than or equal to 3 total metabolic equivalents .
Lipid and lipoprotein measurements
NMR spectra were acquired from EDTA plasma samples as previously described for the NMR LipoProfile® (lipoprotein particle) test at LipoScience, Inc. (now LabCorp-Raleigh, NC) using the LipoProfile-3 algorithm . Mean VLDL, LDL and HDL particle sizes are weighted averages derived from the sum of the diameter of each subclass multiplied by its relative mass percentage. The NMR Profiler platform is comprised of a 9.4 T (400 MHz 1H frequency) spectrometer (Bruker Biospin) with an integrated fluidics sample delivery system. Total cholesterol, triglycerides, LDL-C and HDL-C were measured using standard automated methods.
Total cholesterol and LDL-C demonstrated a normal distribution confirmed with Kolmogorov-Smirnov Goodness of Fit testing. Triglycerides, HDL-C, inflammatory markers (high sensitivity C-reactive protein [hsCRP], interleukin [IL]-1β, IL-6, IL-18, tumor necrosis factor [TNF]-α), and lipoproteins were logarithmically transformed prior to group comparisons. RA and controls (n = 39 each) were compared using mixed models, which accounted for the repeated measure of matched participants. Bivariate associations were assessed with Spearman correlations. Lipoprotein particle modeling was performed with general linear models. All analyses were performed in SAS (Version 9.4, Cary, NC). A priori levels of significance were P < 0.1 for interactions and P < 0.05 for all other analyses.
Lipoprotein profile in subjects with RA
While triglycerides and HDL-C did not differ between RA and controls, both total cholesterol and LDL-C were lower in persons with RA (Table 1; P < 0.05 for both). For NMR-measured lipoproteins as compared to controls, RA had lower concentrations of both total LDL-P and small LDL-P, with a larger mean LDL particle size (Table 1; P < 0.05 for all). While total HDL-P concentrations were similar to controls, RA had a larger mean HDL particle size (Table 1; P < 0.05 for all).
Lipoprotein particle associations with inflammation, pain, and disability in RA
In persons with RA, greater concentrations of the inflammatory cytokines, IL-6, IL-18, and TNF-α, were associated with reduced LDL particle size, (r = −0.31; r = −0.33; r = −0.28; P < 0.05 for all). Medium HDL-P had an inverse association with TNF-α (r = −0.31; P < 0.05). Inflammatory cytokines were not significantly related to small HDL-P; although increased pain and disability were associated with fewer small HDL-P (r = −0.42; r = −0.37; P < 0.05 for both).
Lipoprotein associations with body composition and insulin action in RA
In persons with RA, lipoproteins and lipoprotein cholesterol levels were associated with a number of measures of cardiometabolic risk (Table 2). For LDL, concentrations of both total LDL-P and small LDL-P were associated with greater BMI, waist circumference, abdominal visceral adiposity, homeostasis model assessment of insulin resistance [HOMA-IR], and fasting insulin (Table 2; P < 0.05 for all). LDL-size was associated with insulin sensitivity and inversely associated with HOMA-IR and fasting insulin (Table 2; P < 0.05 for all). For HDL, total HDL-P was associated with insulin sensitivity while small HDL-P was associated with waist circumference (Table 2; P < 0.05 for both). Large HDL-P and HDL-size were inversely correlated with BMI, waist circumference, abdominal visceral adiposity, HOMA-IR and fasting insulin (Table 2; P < 0.05 for all). Medium HDL-P was inversely associated with fasting insulin. LDL-C was associated with BMI, abdominal visceral adiposity and fasting insulin while HDL-C was associated with insulin sensitivity and inversely associated with waist circumference, HOMA-IR and fasting insulin (Table 2; P < 0.05 for all). None of the lipoprotein or lipid parameters were associated with abdominal subcutaneous adiposity.
Lipoprotein associations with physical activity in RA
Since HDL profiles appeared more related to pain and disability than disease activity or inflammation, we hypothesized that in RA, HDL profiles might be impacted by lack of physical activity. In fact, more basal activity time (minimal physical activity) was associated with fewer total HDL-P and small HDL-P (Fig. 1), more large HDL-P, and larger mean HDL-size (Table 2; P < 0.05 for all). On the other hand, more exercise time was associated with a profile that shifted toward more small HDL-P, fewer large HDL-P, and reduced mean HDL-size (Table 2; P < 0.05 for all). Further, the relationship between basal activity and small HDL-P was independent of exercise time and together, both accounted for 29% of the variance in small HDL-P (model P < 0.002; Pbasal activity time < 0.005; Pexercise time < 0.28).
For LDL, more basal activity and less exercise time were associated with fewer small LDL-P (Fig. 1 and Table 2; P < 0.05 for both) and a larger mean LDL-size (Table 2; P < 0.05 for both). More basal activity time remained independently and inversely related to small LDL-P concentrations even when controlling for exercise time (model P < 0.01; model R 2 = 0.23; Pbasal activity time < 0.01; Pexercise time = 0.37).
To determine whether the effects of minimal physical activity and exercise time on lipoproteins were impacted by age, gender, inflammation and adiposity, we performed adjusted linear regression analyses. Analyses targeted small LDL-P and small HDL-P because these were most strongly related to the physical activity measures. Similarly, basal activity or minimal physical activity time was included as the physical activity measure because it had shown stronger bivariate relationships. Basal activity was inversely associated with small HDL-P (P = 0.001) and this association remained significant and unattenuated even after adjusting for age, gender, disability, pain, TNFα, IL-6, BMI and abdominal visceral adiposity (P < 0.05) (Table 3). Pain showed a significant inverse association with small HDL-P in a model that contained basal activity, age, gender and disability (P < 0.05) (Table 3). However, the association of pain with small HDL-P was attenuated after further adjustment for TNFα, IL-6, BMI and abdominal visceral adiposity (P = 0.15). None of the other parameters showed a significant association with small HDL-P (Table 3). Basal activity was also inversely associated with small LDL-P (P = 0.002) and this association remained significant and unattenuated even after adjusting for age, gender, disability, pain, TNFα, IL-6, BMI and abdominal visceral adiposity (P < 0.05) (Table 4). Age and gender were also inversely associated with small LDL-P after adjusting for age, gender, disability, pain, TNFα, IL-6, BMI and abdominal visceral adiposity (P < 0.05). However, these associations were not consistently significant in every model tested (Table 4).
Similar to prior reports, we found that compared to controls, subjects with RA had lower NMR-measured concentrations of total and small LDL-particles, yet larger LDL- and HDL-particle sizes [10, 20]. There were trends toward fewer small particles and/or more large particles in both LDL and HDL lipoprotein classes. Here, we expanded the current knowledge regarding RA lipoprotein profiles and demonstrate associations for each of physical activity, inflammation, and traditional cardiometabolic risk factors. Most similar to the RA lipoprotein profile, more time spent in basal activity (minimal physical activity) and less spent in exercise were associated with fewer small LDL and small HDL particles.
To our knowledge, this is the first report suggesting that the unfavorable HDL profile (fewer small particles) associated with RA may result in large part from minimal physical activity. Among those with RA, basal activity was associated with less small HDL-, fewer total HDL-particles, and an increased mean HDL-size. Additionally, time spent in exercise had the inverse effect on HDL profiles. Further, fewer small HDL concentrations were associated with pain and disability, while there were no HDL associations with cytokines. In persons without RA, exercise is known to exert beneficial effects on HDL-particles [15, 21, 22]. However, these exercise effects are due primarily to increases in large and medium, rather than small, HDL-particles [15, 23]. Thus, our observed effects of inactivity and exercise on small HDL may be unique to those with active RA—and perhaps other inflammatory diseases.
NMR-measured HDL parameters in persons with RA were associated with traditional cardiometabolic risks of adiposity and glucose homeostasis. Most consistently, increased adiposity was associated with fewer large HDL-particles. This reduction in large HDL-particles appears distinct from, and potentially additive with, the inactivity-associated reductions in small HDL-particles, which together may culminate in significant pro-atherogenic effects.
These findings are consistent with recognition that HDL-particles have heterogeneous functions and composition [12, 24]. Typically, both large and small HDL-particles participate in reverse cholesterol transport, the major driver of the inverse relationship between HDL-particles and cardiometabolic disease . Also, HDL-particles exert vasodilatory and anti-thrombotic effects, primarily mediated by large HDL-particles . Additionally, protein-rich small HDL mediate anti-inflammatory and anti-oxidative functions via transport of proteins with anti-inflammatory and immunomodulatory functions . However, in the setting of increased inflammation, such as in active RA, such proteins are replaced with pro-inflammatory and acute phase proteins [12, 14]. Furthermore, HDL transport of inflammatory proteins occurs at the expense of apolipoproteins resulting in less HDL-mediated reverse cholesterol transport . Exacerbating these issues, inflammation increases HDL-particle catabolism and renal clearance resulting in fewer HDL-particles [12, 24].
The relationship between LDL-particles and RA is just as complex. As compared to controls, patients with RA had fewer total and small LDL-particles, resulting in a larger mean LDL-size. The association of excess CVD with lower LDL concentrations has been described as “the lipid paradox of RA;” fewer small LDL particles continues to support a paradoxical relationship. RA-associated inflammation increases cholesterol catabolism such that small, cholesteryl ester (CE)-laden particles, transfer CE to the liver at increased rates, resulting in fewer small CE containing LDL and lower LDL-C . However, in our RA cohort, increased inflammatory cytokines were not associated with fewer small LDL-particles and larger mean LDL-sizes; instead, they were associated with smaller mean LDL-particle sizes. Thus, it appears that the RA-associated LDL profile is not mediated entirely by inflammation. Additionally, as traditional cardiometabolic risk factors were associated with more total and small LDL-particles, it appears the RA-associated LDL profile (fewer total and small LDL) is not mediated by adiposity or insulin resistance.
Interestingly, both less time exercising and more basal or minimal physical activity were associated with fewer small LDL-particles and larger mean LDL-sizes. Further, the effects of minimal physical activity on LDL-particles were independent of exercise time. It may be that less physically active patients are those with higher disease activity and concomitantly have the typical dyslipidemia that is observed in active rheumatic disease (i.e., decreased small LDL- and HDL-particles and normal total and LDL-cholesterol levels). However, rather than larger LDL sizes, smaller LDL sizes were associated with increased concentrations of several inflammatory cytokines. Consequently, rather than concluding that physical activity worsens LDL profiles, it appears more likely that patients who were more active tended to have a reversal of the typical inflammatory dyslipidemia that is observed in RA patients [10, 13, 14]. These lipoprotein changes may be mediated by anti-inflammatory effects of exercise [25–29]. Similarly, lipoprotein changes are observed in RA patients who have been treated with anti-TNF-alpha agents, IL-6 receptor antagonists and JAK inhibitors [13, 14, 30, 31]. Concomitant HDL function improvements suggest these shifts are atheroprotective [13, 31].
We recognize that this study has limitations. The cross-sectional nature makes it impossible to determine causality. A small number of subjects was used for this study, therefore the results may be considered preliminary and larger studies are needed to confirm these results. Also, we recognize that multiple statistical analyses were performed without correction for multiple testing. However, we focused on associations that were consistent across multiple similar, yet independent, measures, reported strengths of associations and ranges of significance such that the reader can consider these in interpretation of the findings.
In this RA cohort with mild to moderate disease activity, we found lipoprotein profiles similar to those previously reported: there were fewer total and small LDL particles in the setting of larger HDL particles, consistent with the RA lipoprotein profile. We identified intriguing associations for basal or minimal physical activity and exercise time with lipoprotein parameters suggestive that a large part of the RA lipid profile is mediated by lack of physical activity. These findings call for intervention studies in RA evaluating the impact of reduced sedentary time, in the setting of increased disability and pain, on lipoproteins and overall cardiometabolic health; they also call for research designed to understand the underlying mechanisms of these observed effects.
Body mass index
Disease activity score
Disease activity score with 28-joint count using erythrocyte sedimentation rate
Erythroctye sedimentation rate
Health assessment questionnaire-disability index
high density lipoprotein
Homeostasis model assessment
High sensitivity C-reactive protein
Low density lipoprotein
Tumor necrosis factor-alpha
Visual analogue scale
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We thank our study participants and the Duke Division of Rheumatology and Immunology clinical faculty who referred patients. Additionally, we appreciate that LipoScience, Inc. (now LabCorp) provided lipoprotein determinations at no cost.
This work was supported by NIH/NIAMS K23AR054904, NIH/NIA NIH/NIA P30AG028716, and an ACR-REF/ASP Junior Career Development Award in Geriatric Medicine funded via Atlantic Philanthropies, ACR-REF, John A. Hartford Foundation and ASP. Additionally, LipoScience, Inc. (now LabCorp) provided lipoprotein determinations at no cost; JDO and MAC are employees, and DAW was formerly an employee, of LabCorp.
Availability of data and materials
The datasets during and/or analyzed during the current study available from the corresponding author on reasonable request.
HA, MAC, and KMH contributed to the data analysis, data interpretation, and wrote the manuscript. HA and KMH also participated in conceptual design. LB, KNT, JLH, and KMH participated in acquisition of data laboratory studies and reviewed/edited the manuscript. VBK, JDO and WEK participated in conceptual design, data interpretation, and reviewed/edited the manuscript. All authors read and approved the manuscript.
Consent for publication
The authors declare that they have no competing interests; DAW, JDO, and MAC are employees of LipoScience, Inc. (now LabCorp).
Ethics approval and consent to participate
The study was in compliance with the Helsinki Declaration and was approved by the Duke University Medical Center Institutional Review Board. All participants signed an informed consent.
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Cite this article
AbouAssi, H., Connelly, M.A., Bateman, L.A. et al. Does a lack of physical activity explain the rheumatoid arthritis lipid profile?. Lipids Health Dis 16, 39 (2017). https://doi.org/10.1186/s12944-017-0427-4


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That was fantastic!
You made it sound very much like the lute piece that it is, and your musicality makes it obvious you've been playing for a long time.
More recordings please!
You are nice!
I was quite uncertain of the reception of my interpretation. Dowland is a sliding ground... And I took the risk to do absolutely no effort to adhere to any standards, for a couple of reasons:
1- I am a living-room amateur player (would like to play more in public but I am just terrified of it...), I play mostly for myself, for my pleasure, and doing stupid stylistic mistakes have no consequences
2- I passed 10 years away from my guitar playing viola da gamba. I am very familiar of that repertory, though in viol consort, not with lute. So the Elizabethan style is familiar to me; that does not mean at all that everything I would do instinctly is accurate, but it should not be stylistic monstruosities neither
3- I play CG, not lute. I think it is a mistake to try to make it sound like something else (i.e. lute) If you want to sound like the lute, play the lute
But of course with CG I can follow the same phrasé and articulations than with the lute, both being plucked strings. So here I could receive some critics...


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Drug Rehab Realities: 5 Ways Addicted Loved Ones Will Try to Manipulate You
Drug addiction destroys lives, damages relationships and devastates families. While a drug rehab center can offer the best solutions for recovery, addicts in denial will do or say just about anything to avoid treatment or to get out of treatment before they are ready. As a result, friends and family members must be constantly aware that addicted loved ones will try to manipulate them any way they can to accomplish their sole objective—to continue using drugs.
If you or someone you know is dealing with an addicted loved one, be on the lookout for these 5 manipulation tactics they will try to use to make you an enabler of their addiction.
Drug addicts are very good at lying to themselves. Eventually, they actually believe that they can quit anytime they want to and that they aren’t hurting anyone else. Once they’ve bought into this twisted reality, they will have no problem lying to friends or family members in order to preserve their addiction. After all, they need to use drugs. And lying about drug use can be an effective way to get you to leave them alone so they can continue using. They know that you love them and that you want to trust them. And statements such as “If you loved me you’d trust me”, are blatant attempts to use your emotions to their advantage. When you catch an addict in a lie the key is to not take it personally. Simply make them aware that you know they are not telling the truth without being accusatory or confrontational.
2. Minimizing the Problem
When an addicted loved one realizes that friends or family members are aware of their drug problem, and lying isn’t working, their next manipulative technique will be to try to minimize the situation. “I only tried it one time,” or “I just do it once in awhile. Its no big deal,” are examples of minimization techniques addicts use to downplay the seriousness of their drug problem. For them, it’s all a part of the denial process. In dealing with this form of manipulation it’s important to show love and support for the person while expressing concern and disappointment about the behavior. This will help to show your loved one that you really do care about them and reduce the chances of a heated confrontation, which will get you nowhere.
3. Laying Blame
The last person a drug addict wants to blame for their behavior is the person staring back in the mirror. That would require taking ownership of the problem and actually trying to get help. The easier way is to manipulate others into thinking that they are the cause of the problem by laying the blame on them. After all, if you had been more understanding and had treated them better, they wouldn’t have needed to turn to drugs in the first place. Laying blame is an effective tool, as it can lead to feelings of guilt among parents and friends that maybe they are partially to blame and could have done more to recognize and prevent the downward slide into addiction. But harboring such feelings generally makes matters worse, as guilt can lead to giving in to requests for money or other favors that ultimately keep fueling the addiction. In dealing with addicted loved ones it’s critical to understand that they are the ones responsible for turning to drugs, not you.
4. Playing the Sympathy Card
Addiction is all about choices and consequences. Once an addict realizes that friends and family members are on to them, and that drug rehab is a real possibility, they will try to manipulate others by playing on their sympathies in order to avoid facing the consequences of their choices. Playing the part of the victim is often an effective way to generate sympathy from others, especially for addicts wishing to avoid rehab. After all, according to them they only started taking drugs in the first place because they felt unloved, unaccepted, or otherwise wounded or suffering. Making them enter a cold and harsh rehab program would only serve to victimize them further. Giving in to this sympathy ploy will only postpone your loved one from getting the help they really need.
5. Pretending to Go Along
Another manipulative tactic that addicts use to get loved ones off their back so they can keep using is to pretend to go along. They get it that arguments often lead to the loss of freedoms that could restrict their access to drugs, so they basically tell their loved ones what they want to hear. “You’re right. I have a drug problem,” and “Yes, I’m going to get my life together and quit,” are the kinds of insincere statements addicts often make to get concerned loved ones to lower their guards just enough to unknowingly let drug use continue.
Recognizing that drug addicts use these and other manipulation techniques to further their addictions can empower you to help an addicted loved one choose a suitable drug rehab inpatient or outpatient program in Utah.

domain: sociology


I watched one of those packaged specials on the news last night about people spending too much time on Facebook. Something like “Facebook Addiction–Where Will it Lead?” The piece had a rather ominous tone, I must say.
I suppose there are folks out there who can’t do without their Facebook fix. Or Twitter tips, or listening in on LinkedIn, or connecting with any of a dozen other social media messaging. Whereas I can walk away anytime I want.
Here’s the thing, grasshopper. From a business standpoint, social media has value. I think Twitter might be better for massive marketing, but I like Facebook for blogging connections. And I like Facebook for personal connections, too. So I want to stay social media savvy. But when I jump into Facebook or Twitter, or even blog surfing, I can easily use up hours.
HOURS. And though I come across tons of informative posts (because seriously, there are a ton of brilliant folks out there, sharing their expertise), I may get a teensy bit carried away, reading one post, zipping to another…then another…then another.
Until I look up and dang. It’s lunchtime and I haven’t written a single word (unless you count scathingly brilliant comments here and there. Which I’m counting. So there.).
But pithy comments do not a manuscript, essay, or short story make. And so I’m forced to face the ugly truth: I may…okay, okay, I have a social media problem. I usually deal with it by going cold turkey for a week or so. And then I ease back in, using moderation.
So don’t over-do the social doings, grasshopper, at the expense of your writing. Write FIRST. Or if you need a little warm-up, set a limit for how much time you’ll spend, media socializing. Then stick to it.
Because when you think about it, it’s your brilliant writing that you’re trying to promote and sell. Pour hours into that, grasshopper, and then use social media to tell the world.
(We shall discuss the proper way to exploit one’s self, using humility, dignified grace, and monkey-mad media marketing skills at a later date.)


London Duck Tours has announced that it's grounding its amphibious boats from today, after one caught fire at the weekend.
Many on board the boat jumped into the water as flames took hold and thick black smoke billowed out. A woman and a child were taken to hospital with suspected smoke inhalation.
The company released a statement saying:
"At this early stage it is not possible to speculate on the reason for the incident. Until the cause is established, the company will not be operating on the river and should technical or safety modifications be required to our fleet, these will be introduced prior to the service recommencing"
More top news
The Duchess of Cambridge has been driven to St Mary's Hospital in London in the "early stages of labour", Kensington Palace has said.
The 20-year-old was found fatally wounded on Roth Walk, near Finsbury Park, north London at around 3am on Saturday, Scotland Yard said.
Police have arrested a man wanted in connection with a burglary at the home of pensioner Richard Osborn-Brooks.


text:
About the TV Show
witch monster underground vampire supernatural possession black magic horror victorian england thriller werewolf devil gothic horror gothic mental illness psychotherapy succubus dark fantasy 19th century supernatural power
First Air Date: May 11, 2014
|First Aired on||:||2014|
|Created By||:||John Logan|
|Genres||:||Sci-Fi & Fantasy,Drama,Mystery|
|Seasons/Episodes||:||27 episodes in 3 Seasons|
Some of literature's most terrifying characters, including Dr. Frankenstein, Dorian Gray, and iconic figures from the novel Dracula are lurking in the darkest corners of Victorian London. Penny Dreadful is a frightening psychological thriller that weaves together these classic horror origin stories into a new adult drama.

domain: entertainment


text:
'Walking Dead' premiere sets record, draws 10.9M viewers
UPI News Service, 10/15/2012
About 10.9 million viewers tuned in for Sunday night's Season 3 premiere of the American zombie drama "The Walking Dead," AMC announced Monday.
The cable network called it the "biggest telecast for any drama series in basic cable history among all viewers."
"Thank you to the fans for making 'The Walking Dead' such a tremendous success. We are honored and humbled that television's largest adult audience resides on AMC. So many people on both sides of the camera worked tirelessly on this project, and I thank and congratulate each of them for their amazing contribution," Charlie Collier, president of AMC, said in a statement.

domain: news


text:
Interesting question. It depends what type or skill level of players you're talking about.
If you're talking about players that don't really have much offence other than whacking the ball, there's not much you can (or need) to practice.
If you're talking about players that can do basic push kicks, pull kicks, and dinks - you can practice racing in either direction repeatedly and making sure your player figures end up in the absolutely correct spots.
If you're talking about tourney level pull shots and snake shots - you can watch videos and try to break down and repeat defensive patterns. You can also try to move around randomly, watch your defense carefully, and think about what you would shoot on it yourself, and build a defensive story around that.
You can also float your men around and then practice moving your men to the correct "kill zone" spots as quickly as possible (I.e., the corners and the middle).
Let me know if this makes sense...
You can alway optimizing your positioning against certain types of shots from the opponents 2-bar by just positioning them around and having a detailled look at holes. Try shooting against your positioning.
Practicing against 3-bar shots is quite hard, the best way to do it is to shoot them on your own and try to memorize what kind of positioning is hard for you to overcome.
Other then that, you actually need an opponent.

domain: game


text:
Bewick, Thomas. Autograph Letter to Longman & Rees.
Date of Publication: 1804
Stock Code: 5453
Single paper sheet approx 210 x 170 mm with address to verso of publishers Longman and Rees of Paternoster Row. Letter of 13 lines dated 17th August 1804 and signed at the foot by Thomas Bewick, regarding an order for his “Quadrupeds”, “shiped on board the Newcastle Packet” and requesting that his publishers use their influence to promote the second volume of “Birds” and have it included in the forthcoming list of new publications in the Monthly Magazine. Bewick’s customary stationary mark with the embossed TB to verso. Creased from folding and cut to lower edge where sealing wax has been removed; a little faint foxing. Paper to upper margin to reverse where letter has been tipped-in. Very Good condition.
The letter illustrates the careful eye that Thomas Bewick kept upon the numbers and sale of his works, and the lengths that he would go to in order to persuade printers, publishers and booksellers to promote his work.

domain: library


Airbnb Is Banning Parties At Their Listings & Rulebreakers Could Face Legal Action
No more big shindigs!
Parties are likely one of the last things on anyone's mind these days. Still, they do happen, and now one of Airbnb's new rules will try to curb them. The company is instituting a full-on party ban, and rulebreakers could face legal consequences.
In an email sent to Narcity, Airbnb said that they would be banning all parties and large gatherings at their listings across the globe.
They note that 73% of their global listings already ban parties in their rules.
The new restrictions will also include an occupancy cap at all listings of 16 people.
"To be clear, we are not sanctioning smaller gatherings with this policy and all community members are expected to comply with local health restrictions on gatherings," the email reads.
The company said that anyone who is found to be in violation of the party ban could face "steep consequences."
Those include being entirely banned from Airbnb, as well as the potential for the company pursuing legal action.
In one example of this, Airbnb pursued legal claims and damages against the host of a Sacramento rental where a party resulted in a deadly shooting.
"The company notified the guest on Monday of its intent to bring legal action, alleging negligence and violation of local health orders, violation of Airbnb’s Community Standards, and that the Guest booked the listing under false pretenses," the company said in a statement to KCRA News.
This event also led to a full ban on what the company considered to be "."
Similar incidents have occurred in Canada, including, as well as one at a prom after-party in .
The company instituted a new rule earlier this year that no onewould be able to book entire houses anymore.
They also set up a 24/7 neighbourhood support line so that people could report any violations directly to Airbnb.


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With the pop-punk titans in town once again, it was time for SFN‘s self-professed Blink-182 superfan Pip Johnson to join the fray at Echo Arena. Here’s his review of the night.
It’s been over five years since pop-punk legends Blink-182 last played Liverpool, now they have finally returned for a night of mayhem, backed with a UK #1 album and a new member behind them along with some killer support.
First up was New Jersey indie rockers The Front Bottoms who started the night off with a bang, with a 30-45-minute set featuring loud thunderous drums and energetic songs such as “Maps and Skeleton”. The Echo Arena does however seem far too larger of a venue for a band of their size, but that didn’t stop them having a blast playing to the crowd who loved every second of it.
After a short break Frank Turner and The Sleeping Souls took the stage (for their 2071st show, as Frank exclaimed after the first song), who we have previously caught at the Guild of Students back in November. Frank had the audience captivated from the second he brought his folk-punk sounds to the stage. His set was full off energy with the entire band moving and dancing on the stage as they played.
Frank brought a huge stage presence and held the audience in the palm of his hand, opening up circle pits left, right and centre, crowd surfing towards the end of his set and even bringing a member of the audience up on stage to play the harmonica during “Dan’s Song”. (Ironically the member of the audience he brought up was called Dan themselves). Frank’s set lasted around 45 minutes to an hour and it left the whole crowd hot, ready and waiting for the main event of the night, Blink-182.
Blink-182 came onto the stage to the sound of the Stranger Things intro and burst right into “Feeling This” seconds before the flag dropped to reveal them and their infamous flaming “FUCK” sign to their crowd. They powered through their set featuring a mixture of classics and songs from California, sadly no Neighborhoods songs made the set, other fan favourites also were missing, stopping occasionally to interact with the crowd during a guitar change. The most notable of which was a brief cover of the Ramones classic “Blitzkrieg Bop” before jumping right into “First Date”.
Anyone who was expecting dick and fart jokes every other song would’ve been disappointed as the band barley made any jokes and the few that they did weren’t that funny, with Mark making a bad joke about legendary Mancuians Oasis being from Liverpool and his “English accent” which was just him saying Alright in weird voice.
The Tom Delonge fanboy inside of me wants to rip into Matt Skiba but there isn’t much that I can complain about, while he is not Tom, Matt still had a great stage presence and chemistry with Mark. It is clear that he has now grown to be a lot more comfy playing in Tom’s spot and does a good job. The only things I didn’t like are minor nit-pics involving using a different guitar and his voice not suiting some of the songs.
Despite the lack of jokes which they are known for and odd nit-pic the show was a highly enjoyable experience and made up for the lack of jokes, especially when they decided to swap out “Happy Holidays You B***ards” for “Family Reunion” towards the end of the set. It is truly an experience which you must experience at some point during your life.
Words by Pip Johnson, featured photograph by Robert Noise. Twitter links credited to their owners.

domain: artistic


text:
In the new Garibaldi district you can admire a new unusual and architectural Milan.
A requalification project which led to the construction of residential buildings, panoramic towers, new business centres, futuristic districts and squares, green areas and cycle paths which have really changed the city’s skyline. Gae Aulenti Square was designed by the Argentinian architect Cesar Pelli and it is one of the most beautiful squares of the new Milan.It is in the eastern zone and you can get it from Porta Garibadi railway station. It hosts Unicredit Tower, which is the highest skyscraper of Italy with its 230 m. The square is decorated with fountains, light works and artistic installations, like the famous sinuous bench-sculpture which runs around three fountains with its 105 m of length. From the square, you can enjoy a beautiful view on Pirelli skyscraper, Diamante Tower and all the new Garibaldi District.
The top 10 things to visit in Milan:
- Duomo of Milan
- Gae Aulenti Square and the new Garibaldi district with its skyline
- La Scala and museum of 20th century
- Sforza Castle
- Quadrilatero della moda (the quadrilateral of fashion”)
- Basilica of St Ambrose
- Academy of Brera
- Navigli, night movida and restaurants
- Meazza Stadium
- St Lawrence’s columns

domain: geography


text:
A new study finds the ability to accurately reflect on perceptual experiences and the ability to accurately reflect on memory is unconnected, suggesting we have distinct introspective skills.
Researchers reveal the precuneus is more connected to the dorsal attention network and less connected to the default mode network in people with chronic tinnitus.
A new neuroimaging study reveals methylphenidate, better known as Ritalin, increases the level of dopamine available in the caudate. Along with increased dopamine levels, researchers also notice greater functional connectivity between the prefrontal cortex, hippocampus and precuneus, three areas of the brain associated with memory and attention.
Researchers find the neurobiological root of happiness in the precuneus.
In a study exploring the neural correlates of the fight or flight response, people who choose to flee perceive a greater threat, leading them to behaviorally and mentally disengage from a situation, researchers report.
Three months of transcendental meditation reduced anxiety and resulted in marked changes in connectivity between the precuneus, left parietal lobe, and insula.
Studies of lucid dreamers visualise which centers of the brain become active when we become aware of ourselves. Studies demonstrate that a specific cortical network consisting of the right dorsolateral prefrontal cortex, the frontopolar regions and the precuneus is activated when this lucid consciousness is attained.
A new study sheds light on how highly sensitive people process information. After experiencing something emotionally evocative, brain activity displayed a depth of processing while at rest. Depth of processing is a key feature of high emotional sensitivity.
Researchers report successfully reducing depressive symptoms in some patients using a non-invasive form of vagus nerve stimulation.

domain: medical


text:
to Health, Education of Women. [India] Observing that women were subjected to
various types of harassment in society, Gursharan Kaur, wife of Prime Minister Manmohan
Singh, today said importance has to be given to health and education of the
fairer sex to
help them out of the crisis. "Women are are getting worse treatment even
today. With respect to health and education, they are lagging behind.
to take the message of health and education to every home," she said while speaking
at a function organised to observe the 60th anniversary celebration of Kasturba Gandhi
National Memorial Trust at Gandhi Smriti here.
Face Risk of FSD. [India] Contrary to popular perception, it's
not just men who
suffer from sexual dysfunction. A great many women suffer from what is
sexual dysfunction (FSD). Doctors, however, say that most of them are
unaware of the
condition and therefore do not seek treatment for it. "Earlier the condition
was thought to exist only in post-menopausal women, but now, for the past couple of years,
we have realised that a high percentage of women from the age of 30 onwards
FSD," said Dr Rajeev Sood, head of department of urology at Ram
Manohar Lohia Hospital.
"In fact, studies abroad have shown that more than 40% women may
FSD as opposed to about 30% men suffering from erectile dysfunction (ED),"
In several parts of India,
the ratio between women and men is now so skewed that
there are only 750 women to every 1,000 men. The nationwide average is 927 to
1,000; in a nation of more than a billion people, that translates to a shortfall of about
40 million womenthe same as the entire population of Spain. Rising prosperity
and a historic preference for boys are exacerbating a worrisome imbalance between the
sexes. Soon after I had arrived in New
Delhi in spring 2002, I was horrified to read
in my morning newspaper that flooding in a Rajasthani village had been traced to a drain
behind a back-alley abortion clinic, which had been blocked with scores of discarded
fetuses. Since then, I've become accustomed to tales of fatal, amateur
terminations and of doctors who make money on the side by breaking a law banning them from
telling expectant couples the sex of their babies and offering discreet abortions
if the child is a girl. I've also heard the laments of young Indian men about the
difficulties of finding a mate; one mainstream newspaper even argued that the upside of
all this extermination is that the cost of dowries will come down due to the
of women. And now that my wife is pregnant again, I'm becoming accustomed to other
mothers praying for a boy on our behalf. Our Rajasthan receptionist and fellow
travelers, I now realize, were actually just being polite.
Access to Justice for Women. [Jordan
] three-month long rights campaign in
has revealed that women are unable to seek access to justice due to financial burdens and
social norms. "Either because of limited financial resources or social stigma,
some women abandon their rights," said Jordanian rights advocate Najah
Mizan, a local NGO which organized the campaign. "It's not easy to have access
to justice when you're poor. You need a lawyer, and not everyone can afford
According to Mizan, lawyers usually charge between 300 and 500 Jordanian dinars (US
$375 and US $625) per case. While a 1972 Bar Association Law guarantees the
provision of legal aid to low-income citizens, human rights activists say that in practice
women are often deprived of it. The campaign, which is to finish on 27
launched by the Ministry of Political Development and Parliamentarian Affairs in
cooperation with Mizan. "Our goal was to raise awareness about each person's
legal rights and obligations," said Rula Haddadin, campaign manager at
known as the Law Group for Human Rights. "Since the first days of
the number of phone calls we've received has increased considerably."
of Women Pour Out Hatred of Sacrilege. [Pakistan] Thousands of
students took part in rallies in the city on Saturday to protest the publication of
sacrilegious cartoons of Prophet Muhammad (PBUH) by some European newspapers.
Thousands of women, most of them veiled, gathered near the Quaid's mausoleum
along with a
significant number of children and men, and protested against the cartoons.
women started gathering at the Gurumandir Roundabout and the mausoleum well before the
scheduled time and moved towards the Old Numaish roundabout reciting the Durood Sharif
along the way. A number of women were carrying their infants with them. A
five-month baby named Fayez had a black band around his forehead. The
"I am here to sacrifice for your sanctity Ya Rasool Allah (PBUH)."
Another child was carrying a down-with-Bush effigy. A large number of
students also participated in the rally. They were carrying banners and placards
inscribed with slogans against Denmark,
the United States
and Pakistani rulers.
Committee Highlights Problems Facing Women in Quake Camps. [Pakistan] Over 30
women sitting in a tent are holding up their right arms high in the air, waiting for their
turn to talk. Many are clutching scraps of paper with meticulous lists
them. One by one they stand up and address the meeting in nervous, shaky voices.
But as the women around them nod in agreement and call out their support, their
confidence grows and so do their voices. This is Muzaffarabad's Female
for most of the women here, this is the first time they have aired their problems in a
public forum. "Women are being empowered and they are enjoying it,"
explained Catherine Harding, a community services officer with the office of
Nations High Commission for Refugees (UNHCR), who initiated the scheme and chairs the
committee meetings. "This is something new and innovative for them.
There's been a real change in the women, they are showing great initiative,"
she said. The Female Committee, which was established by UNHCR, represents some 60
camps in Muzaffarabad district and meets every week in the UN compound in Muzaffarabad,
the capital of Pakistani-administered Kashmir.
MPs to Tackle Sex Discrimination. [Palestine] Ask Huda Naeem how she intends to
use her influence as a newly elected MP for Hamas and she ticks off a list of wrongs done
to women in the name of religion. Forced marriage, honor killings, low pay and girls
being kept out of school are her priorities for change in the Palestinian parliament.
That is when she is not preparing her 13-year-old son to die in the fight
"A lot of things need to change," she said. "Women
in Gaza and
the West Bank should be given complete rights.
Some women and girls are made to
marry someone they don't want to marry. This is not in our religion, it's our
tradition. In our religion, a woman has a right to choose," Naeem
Hopeful of Victory as Elections Begin. [Saudi Arabia] Elections to the Eastern
Province Chamber of Commerce and Industrys board of directors began with Jubail and
Hafr Al-Batin voting yesterday. Voters will go to the polls today in Qatif and
Khafji and tomorrow women voters will cast their votes at the EPCCI headquarters in
Dammam. The final leg of the polling will be in Dammam on Tuesday and
Some 11,000 chamber members, who are eligible to vote, will elect 12 members of the
18-member board and the Commerce and Industry Ministry will appoint the remaining six.
The election to the chamber, which is contested every four years, has
interest than usual because of the six businesswomen candidates. Four
of the women
candidates have formed their own group called Watania (Nationalists), while
candidates are contesting as independents. The victory of two business
women in the
Jeddah Chamber of Commerce and Industry elections has raised hope among the
of their winning the battle and gaining seats in the hitherto all-male board.
Opportunities and the Road Ahead. [Saudi Arabia] The 20-member group of
intellectuals who went before the visit of King Abdullah to China consisted mostly of
women. One of them, Aljohrah Alsodairy (23), spoke fluent Chinese. They made
waves and charmed the Chinese with their excellent quality and positive attitude.
Reem Al-Faisal, world-class photographer, was in China
three months ago, hobbling from one
town to another, six in all, in the Yunnan
Province, south of China to
show her Haj photo
collection. In the last decade, she showed her talent in at least ten cities
in Europe, Asia
and the Arab world. Her work was published and praised in prominent journals like Le
Monde, Le Figaro, The Guardian, Liberation, Canvas and Marie Claire.


MIT researchers have developed “bionic” plants with carbon nanoparticles embedded in their leaves that can detect explosives in real time, according to an article from Live Science. The plants are reportedly sensitive to the key components of several explosives and can wirelessly relay information about the chemicals, when detected, to electronic devices.
Scientists reportedly believe the discovery is a step toward better monitoring of soil contamination. According to Live Science, the research group hopes to increase the number of sensors that can be applied to plants so the instruments can detect a variety of chemicals in the air and groundwater.
Read the entire article here.


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One of my big regrets is that I wasn't able to dive a little more deeply into The Dailies. It just interrupted the flow of this part of the story. There's a lot to these characters in my head, I toy with writing more of their journey later, but who knows? Maybe. Probably not. I couldn't help but drip out a little of this element, though.
Gibson you goddamn tease!
I still hold to the belief that there is a sequel of sorts that follows Michelle's pov in the same way we've followed Peter, only starting from the same point in time as when PoY ends.
I think I understand your reasons: we had a 10 years more of stories about One Inch Punch and friends so it would not make justice to the Dailies to dive in their background in even a two month backstory without harming the pace and flow of PoY. It is a bit sad anyway that you introduced such a interesting characters and not having effective time to develop them a little more. But if you plan to do it after PoY ends, I'll be all for it. Keep up the good work!
Have to agree, would love to see more of these character
I have to echo the other sentiments: I'd love to see these characters' backstory explored more. If you need to do it through a separate comic after POY ends, I'd love to read it.


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On Thursday the Michigan Senate Transportation Committee heard testimony on SB 163 to create a “Choose Life” fundraising license plate. The plate has been frequently requested by prolife citizens. Proceeds from people who wish to purchase the plate would go to a fund to be distributed to programs to help women facing unplanned pregnancies. Bill …Continue reading "Tidbits from the “Choose Life” license plate bill hearing today in the Michigan state Senate"
By Dave Andrusko On Friday Republican leaders in the North Carolina legislature petitioned the U.S. Supreme Court to review a decision by the U.S. Court of Appeals for the 4th Circuit that barred the state from issuing “Choose Life” license plates. Attorneys for Thom Tillis, speaker of the North Carolina House of Representatives, and …Continue reading "North Carolina Legislative Leaders ask Supreme Court to review decision barring production of “Choose Life” license plates"
By Gina Diorio A federal court has ruled North Carolina’s “Choose Life” license plate violates the U.S. Constitution because the state does not also offer pro-abortion plates. Upholding a previous ruling by a federal judge, the three-judge panel of the 4th U.S. Circuit Court of Appeals, based in Richmond, unanimously struck down the plate, …Continue reading "North Carolina’s Choose Life license plate: Is North Carolina discriminating against pro-abortion drivers?"


text:
HEMOLUNG Registry Program
ALung developed the HEMOLUNG Registry Program as part of our commitment to improving the treatment and outcomes of acute respiratory failure patients. The HEMOLUNG Registry Program collects de-identified, real-world patient and Hemolung therapy data to formulate and sustain sound safety, scientific and quality evidence.
Participation in the HEMOLUNG Registry Program is designed to be a simple process. Contributors are asked to record patient and therapy related information on the HEMOLUNG Registry Form and return the form to ALung via email.
Contributors may also request data from the Hemolung Registry to support research questions. Data requests are considered on a case-by-case basis by ALung’s Clinical Science team and Clinical Advisory Board.
HEMOLUNG Registry Program Resources
Indication for Use: The HEMOLUNG is indicated for respiratory support that provides extracorporeal carbon dioxide (CO2) removal from the patient’s blood for up to 5 days in adults with acute, reversible respiratory failure for whom ventilation of CO2 cannot be adequately or safely achieved using other available treatment options and continued clinical deterioration is expected.


text:
Men who supplied 13 kilos of drugs jailed after Encrochat bust
Main article content
Three men who supplied approximately 13 kilos of cocaine and discussed criminal cash assets of over £1.1 million have been jailed for over 35 years in the latest under Operation Venetic - the UK's biggest ever law enforcement operation.
Jake Meade (08/09/1988), Taunton Road, Chadderton, Dale Reid (18/04/1990), of Saxwood Avenue, Blackley, and Liam McGrath (21/01/1987), of no fixed abode, were all jailed yesterday (4 April 2022) after pleading guilty to conspiring to supply class A drugs.
An investigation by detectives found that Meade played the leading role in the organised crime group who used encrypted phones to operate and distribute cocaine.
The group supplied over 13 kilos of cocaine over a seven week period with prices ranging from £37k to £40k per kilo.
Following analysis of encrypted messages over a seven week period, it was found that the group were involved in the high level supply of multi-kilo quantities of cocaine. Meade, operating under the name of 'Cookietender' on his device, orchestrated events with the assistant of Reid - also known as 'Navalhound' and 'Usualbee'. Both men then utilised their trusted courier and storeman, McGrath.
In the messages it was also revealed that the three discussed purchasing a van and installing a hide within it to conceal their drugs and money rather than using a backpack. Their drug dealing operation came to an end when officers swooped in and arrested Meade and Reid following a warrants on 30 July 2020.
Officers seized over £43k in cash, three vehicles, large amounts of designer clothing, handbags and jewellery including a Cartier watch and bracelet, a diamond ring and Louis Vuitton bracelets.
A proceeds of crime hearing will now follow seeking to reclaim the criminally acquired assets and properties.
Meade and Reid were both jailed for 14 years and five months and McGrath was jailed for seven years at Manchester Crown Court, Crown Square for conspiracy to supply class A drugs.
Operation Venetic - a nationwide crackdown led by the National Crime Agency (NCA) into the communications platform EncroChat - is the UK's biggest ever law enforcement operation.
Over 200 arrests have been made under the operation since it launched in the region almost two years ago which has seen detectives investigate numerous investigations into hundreds of high-level suspects.
Detective Sergeant Paul Halliwell, from GMP's Organised Crime Coordination Unit, said: "This was a sophisticated and organised drugs operation which led to multiple kilos of cocaine being distributed across the region. They attempted to hide their operation by using the sophisticated and expensive Encrochat technology but were caught out by us and we were able to see the extent in which they used the phones to run their operation.
"A huge quantity of drugs have been taken off the streets as a result and three more drug dealers have been put behind bars for a considerable number of years, putting an end to their drug dealing days which they attempted to cover up.
"GMP is dedicated to relentless pursuing and disrupting those flooding the region with drugs and will do all we can to bring those involved to justice. Drugs not only pose a risk to those who take them, but they are also often one of the biggest factors that lead to serious violence on our streets.
"Anyone with information about drugs in their area can report it online or by using our LiveChat service at www.gmp.police.uk. Alternatively, contact Crimestoppers anonymously on 0800 555 111."


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Welcome to ABC Radio National. Skip to:
How did Australians lose hard won working conditions in the 1980s?
The Federal Government has been warned that a parliamentary inquiry into the iron ore industry could damage Australia's international image.
A look at all of the latest developments in federal politics with the Conversation's Michelle Grattan.
The often testy relationship between the Abbott Government and doctors has deteriorated further.
Jonathan and the team discuss a few of the big stories.


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English coach Jamie Day will keep a keen eye on the senior footballers when Bangladesh take on Sri Lanka in a FIFA-sanctioned friendly match at the Sheikh Kamal Stadium in Nilphamari today.
The game will begin at 4:00pm with state-owned Bangladesh Television broadcasting live from the 20,000 capacity venue.
Although the match may have the status of an international friendly, both teams look serious about the tie, especially with the looming SAFF Championship in Dhaka next month.
The visitors will definitely be looking to fine-tune their combination before starting their SAFF Championship group campaign against seven-time champions India on September 5, a day after Bangladesh take on Bhutan in one of the opening day’s two matches at the Bangabandhu National Stadium in Dhaka.
However, rather than fine-turning their combination, Bangladesh will aim to select the best senior players to fill the 20-member squad as, aside from defender Tutul Hossain Badsha, Day has left behind 10 players who played the four Asian Games matches. Today he is planning to give other senior and junior players match time to prove themselves before the final selection for the SAFF Championship.
Nevertheless there is an expectation that the hosts will put up a good show against the Islanders, especially after the Bangladesh U-23 squad’s brilliant performances against Thailand, Qatar and North Korea in the Asian Games. The senior footballers want to carry that momentum into the friendly rather than thinking of their own fates in the SAFF squad.
“The match is not only for the senior players. It is a match for the country as a good result will be counted in the FIFA rankings. So the match is important for two reasons, FIFA ranking and as preparation for the SAFF Championship,” former captain Mamunul Islam said over phone.
“We are not thinking of who is going to get a chance in the final squad because we know coach Jamie Day will select the right players and the fitter ones. So we want a good result tomorrow [Wednesday] so that we can go into the SAFF Championship with a good impression.”
Striker Shakhawat Hossain Rony, however, is serious about proving his worth as are the other seniors, who have been eagerly awaiting the encounter following a long-term training camp.
“This match is important for us because we have been training for a long time but hardly got any chance to play the full 90 minutes compared to those who played in the Asian Games as well as a few friendlies in South Korea,” Rony said.
“So, through this match, we will be able to judge our fitness as well as standard and everyone, especially the senior players, are serious about proving the point that they are also capable of being part of the SAFF squad,” Rony continued, adding that a win over Sri Lanka would help Bangladesh go into the SAFF Championship with a winning mentality.
The visitors are also optimistic of putting up a good performance to entertain the spectators, informed our correspondent from Dinajpur.
“It is a crucial match for us,” Sri Lankan coach Nizam Pakeer Ali said. “Bangladesh is a second home for me because I played here many times before. We want to play our best match against Bangladesh and go for a win.”
Statistically, Bangladesh have won 11 of their 16 matches against Sri Lanka and only lost thrice with the latest being a 3-0 defeat to the Islanders in Colombo in 2010.

domain: sports


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This Week's SponsorSave 20% on the award-winning Audio Hijack with coupon code 6C20AH!
By Dan Moren for Macworld
By far the biggest rumor about Apple’s upcoming event–and, I suppose, simultaneously the smallest–is the so-called iPhone SE (and may we hope that it will return some sanity, in the form of capital letters, to iPhone model names?). The supposed 4-inch iPhone would mark the first time that the company would go back to an iPhone with a smaller screen.
But the iPhone SE is significant for a larger, more strategic reason, too. The overall market is changing. Smartphones are selling well, no question, but growth has slowed: One only has to look at the nearly 75 million iPhones sold in the first quarter of 2016–but that number was basically flat compared to the quarter one year before.
Some think this signals “peak iPhone,” an idea that I don’t think is really relevant unless you’re a hardcore investor. But as the modern smartphone industry (and, by no coincidence, the iPhone itself) nears the decade mark, I think the more salient point is that the smartphone market has matured.


|Start:||01 June 2002|
|End:||31 December 2003|
|Department:||Advanced Signal and Information Processing (ASIP)|
EMPIRICO is a R&D project in the fields of wireless and optical communications, whose goal is to design and implement a metropolitan optical ring with DWDM technology and a GMPLS control plane to allow real-time dynamic configuration of optical channels between multiple clients (ASON). Among different possibilities of client networks, wireless local area (WLAN) and wireless personal area (WPAN) networks are to be implemented.
As for technological and functional innovations, we find the implementation of an optical network without existing standard protocols, and without SONET/SDH layer, being able to configure optical channels dynamically and real-time between multiple clients (IP, ATM, TDM…) for huge traffic volumes and multiple data types (voice, video, high-speed data, interactive multimedia, etc) at reasonable costs and managing increasing bandwidths. On the other hand, the optical ring is to be interconnected to WLANs, applying multichannel techniques to WPAN and WLAN access networks to improve their functionalities in terms of capacity, coverage and resistance to interferences. EMPIRICO’s methodology encompasses the construction of a multisensor WPAN probe and more detailed knowledge of indoor propagation conditions, the construction of an optical network, the internetworking of wireless and optical networks, Matlab/Co-centric/Opnet simulations and analytical developments.


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2 edition of Shakespeare"s tragedies, and other studies in seventeenth century drama. found in the catalog.
Shakespeare"s tragedies, and other studies in seventeenth century drama.
|The Physical Object|
|Pagination||vii, 232 p. ;|
|Number of Pages||232|
24 According to an acquaintance's report in the early seventeenth century, Shakespeare as godfather at the christening of one of Jonson's children teased Jonson about his constant practice of translating from Latin, by proposing to give the baby a dozen "latten" spoons for the father to "translate" (S. Schoenbaum, William Shakespeare:A Compact An engaging book spanning the fields of drama, literary criticism, genre, and performance studies, Drama: Between Poetry and Performance teaches students how to read drama by exploring the
Politics and Aesthetics in European Baroque and Classicist Tragedy is a volume of essays investigating European tragedy in the seventeenth century, comparing Shakespeare, Vondel, Gryphius, Racine and several other vernacular tragedians, together with consideration of neo-Latin dramas by Jesuits and other playwrights. To what extent were similar themes, plots, structures and styles elaborated??language=en. Stuart Women Playwrights, – (Studies in Performance and Early Modern Drama) - Kindle edition by Cuder-Dominguez, Pilar. Download it once and read it on your Kindle device, PC, phones or tablets. Use features like bookmarks, note taking and highlighting while reading Stuart Women Playwrights, – (Studies in Performance and Early Modern Drama).
The Curious Researcher:A Guide to Writing Research Papers:Florida State University Edition
Together in theatre
change of scene
SOLISOL-handling of solid solutions
The Chinese scholars studio
picturesque and the sublime
Report of program activities: National Institute of Allergy and Infectious Diseases
Survey of industrial coal conversion equipment capabilities
Abelards contribution to the development of logic.
Get this from a library. Shakespeare's tragedies, and other studies in seventeenth century drama. [Clifford Leech] 作者：Leech, Clifford 出版社：Chatto & Windus 出版时间： 印刷时间： 页数： ，购买Shakespeare's Tragedies and Other Studies in Seventeenth Century Drama等外文旧书相关商品， Read this book on Questia. Shakespeare's Tragedies: And Other Studies in Seventeenth Century Drama by Clifford Leech, | Online Research Library: Questia Read the full-text online edition of Shakespeare's Tragedies: And Other Studies in And other studies in seventeenth century drama.
book Century Drama (). /shakespeare-s-tragedies-and-other-studies-in-seventeenth. Shakespeares History Plays by A. Hoenselaars, Shakespeare S History Plays Books available in PDF, EPUB, Mobi Format. Download Shakespeare S History Plays books, This volume addresses attitudes to Shakespeare's English history plays in Britain and abroad from the early seventeenth century to the present :// Comment: From the Foreword: This revised and enlarged index to the imagery in the tragedies of Shakespeare's chief seventeenth-century contemporaries should provide the serious student of Renaissance drama with an improved tool for the study of the language of tragedy as such, and therefore also characterization, mood, handling of chief ideas, dramatic impact upon the audience, › Books › New, Used & Rental Textbooks › Humanities.
(Shakespeares Earliest Tragedies Book Report/Review, n.d.) Shakespeares Earliest Tragedies Book Report/Review. and Jonson’s Bartholomew Fair and ‘To Penhurst’ are texts that give a glimpse of the prevalent issues ofthe seventeenth century English society.
There is a basic similarity in the three of them as each of the themes is deeply VVilliam Shakespeares comedies, histories, & tragedies Published according to the true originall copies.
London, The life and death of the merry deuill of Edmonton With the pleasant prancks of Smug the smith, Sir Iohn, and mine host of the George, about the stealing of :// shakespeare and cognition aristotles legacy and shakespearean drama By Paulo Coelho FILE ID acf Freemium Media Library shakespeares plays this book explores five key objects images in shakespeares plays crowns bells rings whilst rooted in the late sixteenth early seventeenth century have retained their appeal for :// Dr Rankin's first book, Between Spenser and Swift: English Writing in Seventeenth-century Ireland (Cambridge UP, ) explored the transition from soldier to settler across the turbulent seventeenth century and was awarded the American Conference for Irish Studies prize for Best Book on :// This book examines the many and varied uses of apocalyptic and anti-Catholic language in seventeenth-century English drama.
Adrian Streete argues that this rhetoric is not simply an expression of religious bigotry, nor is it only deployed at moments of political :// Navigating the sea of published commentary on Shakespeares tragedies can be difficult.
This book guides students through the key critical debates from the sixteenth century to the present day, enhancing their enjoyment and broadening their critical Guide presents fourteen recent critical interventions in the field of Shakespeare studies, including pieces by Jonathan Dollimore › Kindle Store › Kindle eBooks › Literature & Fiction.
Nearly a half-century ago, in his widely read Opera as Drama, Joseph Kerman devoted a chapter to what he called the “Dark Ages” of opera. 1 In the chapter, much of which offers a disparaging assessment of the qualities of French opera, he described the tragédie en musique as a “stilted entertainment combining baroque excesses with About Eight Tragedies of Shakespeare.
The seventeenth century saw the brief flowering of tragic drama in western Europe as a whole and in England in particular. It was, argues Victor Kiernan, the artistic expression of the consciousness of change which permeated every aspect of life during this :// Tragedies, comedies and histories List of Shakespeare's plays by genre.
The groups below are the classification of Shakespeare’s plays according to the First Folio, a collection of 36 of Shakespeare's plays published in by his :// William Shakespeare - William Shakespeare - Feminist criticism and gender studies: Feminist and gender-study approaches to Shakespeare criticism made significant gains after Feminists, like New Historicists, were interested in contextualizing Shakespeare’s writings rather than subjecting them to ahistorical formalist analysis.
Turning to anthropologists such as Claude Lévi-Strauss /William-Shakespeare/Feminist-criticism-and-gender-studies. 2 days ago You are encouraged to engage with, and to see the relationship between, the plays and poems Shakespeare wrote in the seventeenth century, in which the dominant genres were tragedies and tragicomedies.
The module will cover the second half of Shakespeare’s career in chronological order, from to Histories & tragedies. book by Doug Moston At present this is the only facsimile edition Mr. William Shakespeares comedies the Shakespeare folio available.
With its relatively affordable price and availability the Routledge facsimile is an attractive edition of Shakespeare for readers, but there are short comings to this facsimile/5(5). The first full-length study of how the concept of the "girl" was constructed in sixteenth and seventeenth century literature and drama.
The Girlhood of Shakespeare's Sistersargues for a paradigm shift in our current conceptions of the early modern sex-gender system, challenging the widespread assumption that the category of the "girl" played little or no role in the construction of gender in The tragedies are used because: (1) dramatic texts provide the best information on colloquial speech of the period; (2) the psychological soliloquies in the tragedies provide the access to inner life that is necessary for a proper test of politeness theory; and (3) the tragedies represent the full range of society in a period of high relevance Thomas Killigrew and the Seventeenth-Century English Stage.
by Philip Major. Studies in Performance and Early Modern Drama. Thanks for Sharing. You submitted the following rating and review. We'll publish them on our site once we've reviewed › Home › eBooks. Author: Naseeb Shaheen Publisher: University of Delaware ISBN: Size: MB Format: PDF View: Get Books.
Biblical References In Shakespeare S Plays Biblical References In Shakespeares Plays by Naseeb Shaheen, Biblical References In Shakespeare S Plays Books available in PDF, EPUB, Mobi Format. Download Biblical References In Shakespeare S Plays books, This Shakespeare's tragedies: and other studies in seventeenth century drama.
by Clifford Leech 3 editions - first published in Download DAISYApocalypse and anti-Catholicism in seventeenth-century English drama, by Adrian Streete, Cambridge, Cambridge University Press,xii + pp., £ (hardback), ISBN


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Monday, May 19, 2014
Jan gets some Wisdom from Alice
This was a beautiful journal to receive, so well made and inviting.
I have taken my lead from the Wisdom of Alice. Begin at the beginning and go on till you come to the end. Then stop.
I looked at a few sayings from Alice and the one I chose really took my fancy. I liked the tea cups theme too and with help from a UTube by Vicky Papaioannou , I had fun creating my page.
This was the base I worked on, I collaged on some images of cards. Then I collaged on the tea cups I created and some vintage Alice images.
I also am in love with my special helpful hint envelope with a lovely picture and saying.


Apple's iPhone 7 isn't out yet, but iPhone 7S rumors are already heating up the internet. Here's everything you need to know about the iPhone 7S, including rumors that it'll have an AMOLED screen and a glass back.
Flexible screens have stayed just around the corner for a long while, but a recent South Korean report, when coupled with Samsung's tech investments, indicates that Samsung may commercialize flexible screens in 2017.
Apple may be in talks with various display suppliers to build OLED panels for the iPhone 8, according to new reports. Samsung, LG and Japan Display are all attached to the project, according to rumors.
OLED panels have graced televisions and smartphones for several years, but have been absent in laptops and computer monitors. At CES 2016 that finally changed, and it marks a huge leap forward in display quality.
CES 2016 kicks off with a slew of cool tech to see and experience. VR is a major theme for the show, and we check out the first consumer ready VR camera. Also, get an exclusive first look at LG's newest OLED.
LG plans to open an OLED factory in 2018, spending $8.7 billion on the facility to build all types of displays. The factory might be the first to manufacture OLED displays for the iPhone, with Apple apparently looking for an OLED supplier.
LG shows off its latest ode to OLED at South Korea's Incheon International Airport in the form of two monstrous OLED structures. Composed of 140 individual curved displays, the structures are 13 meters tall, and 8 meters across.