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Monday, 6 April 2015
Small and Wonderful Things . . .
"The world is fairly studded and strewn with pennies cast broadside from a generous hand. But who gets excited by a mere penny?...It is dire poverty indeed when a man is so malnourished and fatigued that he won't stoop to pick up a penny. But if you cultivate a healthy poverty and simplicity, so that finding a penny will literally make your day, then, since the world is in fact planted with pennies, you have with your poverty bought a lifetime of days. It is that simple. what you see is what you get." ~Anne Dillard
A few of the small and wonderful things which bring untold joy into my life. It's the small things in life which truly mean the most. Simple abundance . . . it's the best.
The spiritual nourishment which we have been able to partake of over this past Easter Weekend. I love how Spring Conference almost always co-incides with Easter. Listening to the talks always helps to lift this special time of year above Easter Eggs and Chocolate Bunnies. A few gems which I took away were these:
"No other work transcends that of righteous, intentional parenting." ~Russell M Nelson
"God invites all His children to obtain His help to overcome and endure the challenges of this life." ~Joseph W Sitati
"We see God's miracles in His wondrous work and in our own personal lives."
~Neil L Anderson
"How we live our religion is far more important than what we may say about our religion."
~Robert D Hales
"With the gift of God's Grace, our path of discipleship does not lead backward; it leads upward."
~President Dieter F Uchtdorf
"Today we celebrate the gift of victory over every fall we have ever experienced, every sorrow we have ever known, every discouragement we have ever had, every fear we have ever face."
~Jeffrey R Holland
"All of us need the Saviour's Atonement. All of us need to be found."
~Brent H Neilson
"Life is not confined to a four inch screen."
~Jose A. Teixeira
"We come to church not to hide our problems, but to heal them."
~President Dieter F Uchtdorf
"We can thrive and bloom if we are rooted in our love for the Saviour."
~Quentin L Cook
And that was just the tip of the iceberg. I always take a ton of notes and I listen to the talks over and over again in the coming months . . . each time taking another gem from them. Spiritual nourishment. It's the best.
Bunny, bunny, bunny, bunny, bunny, bunny . . . gone. And it was good. Lindt. Sigh . . .
Scores and scores of daffodils garnishing all the roadsides and dotted across fields, in gardens, etc. I love their sunny little bobbing heads. Nothing is so cheerful as the sight of them. One day I will travel up to Ullswater at this very time of year to see what inspired Wordsworth to write his poem.
I wander'd lonely as a cloud.
That floats on high o'er vales and hills,
When all at once I saw a crowd,
A host of golden daffodils . . .
Todd's son is being buried tomorrow. We are going to the Temple. I am grateful that we have a place to go where we can find peace on a most difficult day.
This lovely girl we have been able to share our home with over these past eight months. She is such a joy and brings such light into our home with her pleasant disposition and sense of humor. It's not always easy to share your home with a stranger, but she has been very easy to live with. We are really going to miss her when she leaves us to get married. We have been blessed.
Be it ever so humble . . .
All in all this weekend was really special. Yesterday the sun shone gloriously and it was very mild. We have not needed the heat on for several days now. That's great! Got to talk to my mom, dad and sis yesterday for a bit, also great! Ate some good food and a few treats. Got well fed spiritually. Spent it with my honey bunny.
I am blessed.
A thought to carry with you through today . . .
"Sometimes I need only to stand
wherever I am,
to be blessed."
In the English Kitchen today . . . BLT Pasta Salad. Seriously tasty!
I hope that your week will be filled with many small and wonderful things! Don't forget . . .
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And I do too!
As we are off to the Temple early tomorrow you may not hear from me until we get back, as well on Wednesday they are putting in our new windows and so I may not be around much that day either! Just wanted you to know so that if I can't make it on, nobody worries!

domain: literature


The above video features game footage of Colorado commit Xavier Newman in DeSoto High's 55-41 Texas Class 6A Division II state quarterfinal win this past weekend against rival Cedar Hill at AT&T Stadium in Arlington.
The 6-foot-3, 272-pound Newman starts at left tackle for DeSoto, which features about 20 players with FBS offers, including three Colorado commits in Newman and four-stars KD Nixon and Laviska Shenault Jr.. Newman's high school playing experience has largely come at tackle, but he projects best to the interior in college and could be a high-potential center prospect.
Newman, Scout's No. 2 center in Texas and the No. 6 center nationally for the 2017 recruiting cycle, spearheads a DeSoto offensive line that also features four-star guard and LSU commit Edward Ingram, plus three-star tackle and Missouri pledge Hyrin White. That trio led a DeSoto offensive front that helped the Eagles run for 229 yards and 5.3 yards per carry in the 14-point state quarterfinal win against Cedar Hill.
DeSoto's offense gained 558 yards, with TCU-bound four-star quarterback Shawn Robinson accounting for more than 400 yards and six touchdowns.
Newman's DeSoto squad is 14-0 entering Saturday's Texas Class 6A Division II state semifinal against Klein Collins at NRG Stadium in Houston.


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Play Now Free Mobile Games on zapak.com
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Griddlers Deluxe is a logic puzzle game where you have to color blocks to reveal pictures and patterns hidden in the grid. Other names for these paint by pixel style puzzles are Nonogrames, Hanjie or Japanese Crosswords. The numbers in the puzzles are show you how many unbroken lines of filled-in squares there are in any given row or column. You should start every puzzle with coloring the blocks that are undoubtedly colored and then deduct the placement of other blocks. Two different control sets make Griddlers Deluxe easy to play on mobile, tablet and desktop Play Griddlers Deluxe now for free, try to solve all the puzzles and find the hidden patterns!
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BB is a fast paced arcade game that is about perfect timing and great strategizing skills at the same time. The objective of the game couldn't be more simple: Stick pins in a revolving orb and make sure they don't get in contact with other pins. Each level requires you to shoot a given number of sticks into the orb. Of course winning at BB is not THAT simple. To succeed you need perfect aim and excellent timing. There is no second chance, each shot has to be absolutely perfect. Try your hand at this highly addictive game and test your skills! Showcase your precision and focus in 75 fantastic levels as you shoot out one pin after the other.
My Little City
My Little City is the latest Match-3 challenge for aspiring city planners! The City Council has commissioned your company to prepare countless new building plots for construction. They need you to ensure the construction projects go according to plan! Supply building materials such as stones, windows, water, electricity, and more! Make the city colorful and free from old walls, dry floors, and broken fences. Collect sufficient building materials and tools. In order to complete the tasks on time, you have various boosters like sledgehammers, dynamite, or paint bombs at your disposal. Complete missions to earn rewards or try your hand at daily challenges that will never get boring! Play My Little City for free now and build your own Little City!
Games for Girls, Puzzle Games

domain: game


July 22, 2019
CONWAY — Ten cadets became Arkansas wildlife officers during graduation July 19 at Antioch Baptist Church in Conway. They completed 18 weeks of instruction at the Arkansas Game and Fish Commission’s H.C. “Red” Morris Enforcement Training Center at Mayflower.
June 12, 2019
LITTLE ROCK — Is anything more popular at a tailgate or holiday party than Buffalo chicken wings? We’ve taken the Buffalo chicken wing craze and crossed it with fried catfish, another Southern staple, and thrown in a little Cajun spice for good measure.
May 23, 2018
ROLAND - Visitors to Pinnacle Mountain State Park probably have noticed Rattlesnake Ridge, which divides the Maumelle River and Little Maumelle River watersheds. As the state’s 73rd natural area, dedicated May 2, its 373 acres will provide a playground for outdoor enthusiasts.
April 11, 2018
HOT SPRINGS - This summer, researchers from the Arkansas Game and Fish Commission and the University of Arkansas at Monticello will attempt to determine whether bear zone 4, in the Gulf Coastal Plain of southern Arkansas, will join the state’s four bear zones open for hunting.
Aug. 30, 2017
Bentonville’s annual World Champion Squirrel Cook Off draws press from across the country but it’s no gimmick. Gumbo, tamales, pizza, sushi, empanadas, tacos, burgers and other delicious dishes get the “limb chicken” treatment.


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From Hartford Courant – Six Moments From The Ned Lamont, Bob Stefanowski Debate.
“If you want higher taxes, vote for Mr. Lamont.”
Who said it? Stefanowski
The business executive from Madison slammed Lamont’s plan to restore a popular property tax credit to help middle class homeowners.
“You know how large his property tax cut is? $100,’’ Stefanowski said. “At the same time he’s going to put up tolls that cost people hundreds of dollars a month. He’s going to raise income taxes and he’s going to bring a statewide auto tax.”
The Greenwich businessman criticized Stefanowski’s plan to phase out the state income tax, saying it would blow a massive hole in the state budget.
“You said you’re going to eliminate over half of our budget, eliminate over half the revenue to support it. That would mean dramatic property tax increases,’’ Lamont said.
“That’s just out of fantasy land.”
Who said it? Lamont
He was referring to Stefanowski’s plan to avoid instituting highway tolls by partially privatizing roads and bridges.
“Even private enterprises need a way to get a return on their investment,’’ Lamont said. “I would put tolls on the big tractor trailers coming in and out of this state. Right now we have a transportation fund that’s going bankrupt.’’
See the full article from the Hartford Courant online.

domain: finance


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domain: health


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ClientCanadian Lakes Property Owners Corporation (CLPOC)
LocationMecosta County, MI
Canadian Lakes is a private community that encompasses many waterbodies that offer plenty of recreational opportunities. Most of the Canadian Lakes are manmade, exhibiting expanses of shallow water with moderate to dense plant growth. These areas are of primary concern as invasive species have the potential to take over a large portion of the lakes. Through the selective use of herbicides and mechanical harvesting, invasive species are being held at bay, allowing the beneficial native plants to thrive to provide excellent fish habitat. Lake management activities and other helpful resources are published by Progressive AE on www.canadianlakesmgmt.org.
To control the spread of invasive exotic plants and to establish a baseline from which to gauge long-term changes in water quality.
Utilizing both mechanical harvesting and select aquatic herbicide treatments allow CLPOC members to enjoy the Canadian Lakes in a variety of recreational opportunities.

domain: geography


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Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice
© Stanton et al; licensee BioMed Central Ltd. 2011
Received: 28 July 2010
Accepted: 16 March 2011
Published: 16 March 2011
Obesity and inflammation are highly integrated processes in the pathogenesis of insulin resistance, diabetes, dyslipidemia, and non-alcoholic fatty liver disease. Molecular mechanisms underlying inflammatory events during high fat diet-induced obesity are poorly defined in mouse models of obesity. This work investigated gene activation signals integral to the temporal development of obesity.
Gene expression analysis in multiple organs from obese mice was done with Taqman Low Density Array (TLDA) using a panel of 92 genes representing cell markers, cytokines, chemokines, metabolic, and activation genes. Mice were monitored for systemic changes characteristic of the disease, including hyperinsulinemia, body weight, and liver enzymes. Liver steatosis and fibrosis as well as cellular infiltrates in liver and adipose tissues were analyzed by histology and immunohistochemistry.
Obese C57BL/6 mice were fed with high fat and cholesterol diet (HFC) for 6, 16 and 26 weeks. Here we report that the mRNA levels of macrophage and inflammation associated genes were strongly upregulated at different time points in adipose tissues (6-16 weeks) and liver (16-26 weeks), after the start of HFC feeding. CD11b+ and CD11c+ macrophages highly infiltrated HFC liver at 16 and 26 weeks. We found clear evidence that signals for IL-1β, IL1RN, TNF-α and TGFβ-1 are present in both adipose and liver tissues and that these are linked to the development of inflammation and insulin resistance in the HFC-fed mice.
Macrophage infiltration accompanied by severe inflammation and metabolic changes occurred in both adipose and liver tissues with a temporal shift in these signals depending upon the duration of HFC feeding. The evidences of gene expression profile, elevated serum alanine aminotransferase, and histological data support a progression towards nonalcoholic fatty liver disease and steatohepatitis in these HFC-fed mice within the time frame of 26 weeks.
Increased adiposity with the consequence of chronic low-grade inflammation and insulin resistance or type 2 diabetes has been linked to the development of nonalcoholic fatty liver disease (NAFLD). Currently, up to 30 percent of the general population is affected by NAFLD with 35 to 50 percent of obese adults also being diagnosed with nonalcoholic steatohepatitis (NASH). NAFLD has been described as the emerging clinical problem for the obese patient in the 21st century . The pathways that are active in promoting this disease process in the liver both in humans and in mouse models are poorly understood and are an active area of research.
There are a number of observations in the literature linking adiposity with inflammation and increased liver disease. Adipose tissue from obese people contains an increased number of CD68+ macrophages with a pro-inflammatory phenotype . In insulin-resistant patients with fatty liver disease, there is a significant upregulation of genes involved in fatty acid partitioning and binding proteins, monocyte recruitment and inflammation . Obese mice demonstrate a significant increase in plasminogen activator in the fatty liver . Likewise, the absence of CCR2 protects the liver against fat accumulation in the diet-induced obese mouse .
In the attempt to model the human disease process in rodents, researchers have used several versions of the Western diet and have found differences in severity of disease and times of disease onset depending upon the type of fats used for feeding. Mice fed diets high in trans fats combined with high fructose in the drinking water develop very aggressive liver disease within two months whereas mice fed only 20% of calories from high fat develop liver disease in nine months [6, 7]. The genetic background of the rodent (C57BL/6 versus DBA/2) as well as cholesterol content of the diet and even the presence of endotoxin has been documented to strongly influence the development pattern of liver disease [8, 9]. Zheng et al.  in our institution use a rodent model which incorporates a 45% fat diet with 0.12% cholesterol to reflect approximate percentages found in the Western diet. This rodent model has all the hallmarks of obesity, insulin resistance, and liver steatosis plus it offers the further advantage of proven use for the investigation of therapeutic drugs relevant to these diseases, such as ezetimibe .
As a prelude to the use of the model in other drug studies, we attempted to determine the molecular pathways that were activated in this mouse model of high fat and cholesterol (HFC) feeding as the syndrome progressed towards liver steatosis and fibrosis. We used a sensitive and high throughput technology, Taqman Low Density Array (TLDA) to study message expression profiling of 92 genes representing macrophage-associated, inflammation-related and metabolism-driven genes in various tissues, including the adipose tissues and liver at 6 weeks, midway at 16 weeks and at 26 weeks post-HFC feeding. We report here that there is an initial upregulation of genes in the epididymal adipose tissue that is accompanied by a relatively quiescent liver profile at 6 weeks post-HFC followed by a dramatic shift in emphasis away from the epididymal adipose tissue to liver tissue gene activation at 16 weeks and 26 weeks. Capturing changes in gene expression profiles from different organ systems as disease progression of the liver is actively occurring will allow valuable information on molecular mechanisms leading to NAFLD and NASH to be gathered in animal models of obesity and will lead to the identification of new therapeutic targets.
Animals and Diet
Six week old C57BL/6 male mice (Charles River Laboratories, Wilmington, MA) were housed in individual cages and kept at a temperature of 22°C and maintained on a 12:12 h light/dark cycle. Three separate cohorts of mice were used for these experiments so that evaluations could be performed at 6 weeks, 16 weeks and 26 weeks post-high fat feeding. Mice were fed a semi-purified diet containing high fat and cholesterol (45% Kcal from lard/soybean oil; 20% Kcal from protein; 35% Kcal from carbohydrate and 0.12% cholesterol by weight obtained from Research Diets (D0401280; New Brunswick, NJ) beginning at 7 weeks of age. Separate cohorts of age-matched normal animals were maintained on regular chow (Purina #5053) which provides 24.65% Kcal from protein; 62.14% Kcal from carbohydrate; and 13.2% Kcal from fat. The mineral and vitamin components were comparable between the two diets. C57BL/6 mice do not all gain weight on a uniform basis when fed this high fat diet. In order to minimize variability in our gene analysis results, mice were selected for their susceptibility to diet-induced obesity at day 21 following the start of high fat and cholesterol (HFC) feeding. Animals were considered to be diet-obese (DIO) if there was a seven gram body weight gain or greater after 21 days. In the cohorts of 150 mice started for each of these experiments, approximately 17% of mice fail this selection criterion on day 21 and are eliminated from further study. Body weight was followed throughout the course of the experiment. Total body fat was determined by use of a whole body magnetic resonance imager (EchoMR11200; Echo Medical Systems, Houston, TX).
Assessment of serum metabolic parameters in diet-induced obese mice post-HFC initiation.
fat pad, %
fat pad, %
serum amyloid A
Blood samples for lipid profile, cytokine analysis and liver enzymes were taken on the day of termination from non-fasted animals at approximately the same time. All studies were carried out in our vivarium in accordance with the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health and the Animal Welfare Act under the supervision of our institutional Animal Care and Use Committee.
Serum Cytokines and Other Mediators
Serum was evaluated for GM-CSF, insulin, leptin, MCP-1, IL-6, TNF-α, IL-10, IL12p70, IL-1β, KC (Meso Scale Discovery, Gaithersburg, MD); serum amyloid A (Life Diagnostics, West Chester, PA); alanine aminotransferase (ALT) (Catachem, Bridgeport, CA) and adiponectin (R&D Diagnostics, Minneapolis, MN). Data from cytokine and mediator evaluation is reported as the mean (sem) of the group. All statistical analysis was performed by Mann-Whitney U test using GraphPad Instat version 3.06 for Windows XP (GraphPad Software, San Diego, CA).
Histology and immunohistochemistry (IHC)
5 μm paraffin sections were stained by either hematoxylin and eosin (H&E) or Masson trichrome stain . For IHC and oil red O staining, frozen liver or adipose tissues embedded in OCT were cut at 5 (IHC) or 10 μm (oil red O) and freshly frozen in -80°C freezer until use. After fixation with acetone, tissue sections were incubated with anti-CD11b (BD Bioscience), anti-CD11c (Endogen), anti-IL-1β (R&D) or anti-F4/80 (Serotec) for 1 h at room temperature followed by incubation with either biotinylated rabbit anti-rat or donkey anti-goat antibodies. Selective binding was visualized by the enzymatic reaction of an alkaline phosphatase (ABC kit, Vector) with its substrate, permanent red (Dako). Hematoxylin was used for counterstaining. Oil red O staining was carried out as described .
RNA isolation and quantitative RT-PCR
Tissue collection and homogenization
Approximately 300-500 μl of blood from each mouse was collected and added to a PAXgene blood RNA tube containing ~1.3 ml of a proprietary reagent developed by PreAnalytiX. Pancreas was isolated using a method adapted from Mullin et al. . Remaining tissues (mesenteric lymph nodes, mesenteric fat pad, epididymal fat pad, spleen, liver and gastrocnemius muscle) were excised and flash frozen in liquid nitrogen.
A TissueLyser (Qiagen, Valencia, CA) was used to homogenize and disrupt collected tissues in preparation for total RNA extraction. A sterile 5 mm stainless steel bead and 1 ml QIAzol lysis reagent (for epididymal and mesenteric fat pads), 350 μl buffer RLT (for mesenteric lymph nodes) or 2 ml buffer RLT (for liver, spleen and gastrocnemius muscle) was added to each 2 ml eppendorf tube containing the frozen tissue piece. Tissues were then agitated at 30 Hz for 2 × 2 minutes as per the recommendations of the Qiagen TissueLyser handbook. A handheld TissueMiser (Thermo-Fisher Scientific) was used to homogenize and disrupt the pancreas tissues.
RNA isolation and cDNA synthesis
Total RNA isolation from all tissues was performed according to manufacturer's protocol (Qiagen, Valencia, CA). Optional on column DNase digestion was performed on all tissues. Total RNA from blood was isolated on the day it was collected using PAXgene Blood RNA kit. All isolated total RNA was stored at -80°C until further use. RNA was quantified using the NanoDrop® ND-1000 spectrophotometer (Agilent Technologies, Santa Clara, CA). RNA quality was assessed by running a 500-2000 ng sample on a MOPS buffered formaldehyde gel. First strand cDNA synthesis was performed using the Applied Biosystems High Capacity cDNA Reverse Transcription kit (Applied Biosystems, Foster City, CA) according to manufacturer's instructions. To ensure equal loading of all samples on the TLDA card, cDNA was quantified against an 18S standard curve prepared using human universal reference total RNA purchased from Clontech (BD Biosciences Clontech, Heidelberg, Germany).
Taqman Low Density Array
Quantitative real-time PCR utilized custom made TaqMan® Low Density Array (TLDA) from Applied Biosystems and followed the manufacturer's instructions. Thermal cycling was performed using an ABI Prism 7900HT Sequence Detection System. 100 ng cDNA in 100 μl of Applied Biosystems 1X Universal PCR Master mix was loaded onto each port of the TLDA plates. Data was analyzed using SDS v2.2 software. The Ct value of each gene is normalized to 18S to obtain ∆Ct. Relative quantitation or fold changes in gene expression were determined using the formula 2-∆ ∆ Ct, where ∆∆Ct = average ∆Ct of all HFC-fed samples - average ∆Ct of all chow-fed samples. Statistical significance was determined by two-tailed Welch t test using either GraphPad Prism 4 or Microsoft Excel 2003, where P < 0.05 (*), P < 0.01 (**), and P < 0.001 (***). Unmarked data points are not significant. The numbers of mice in each group are as follows: 7 Chow-fed and 15 HFC-fed mice at 6 weeks; 8 Chow-fed and 10 HFC-fed mice at 16 weeks; and 10 Chow-fed and 12 HFC-fed mice at 26 weeks.
We measured a variety of serum cytokines and mediators from these animals at the observation points. We found that there was a large degree of variability in these animals despite pre-selection for diet-induced obesity (DIO). We routinely kept the animals on a HFC diet for 3 weeks prior to entrance into the experimental cohorts to ensure that all animals chosen had at least a 30% increase in body weight when compared to chow-fed mice. Of the adipokines measured, serum leptin levels continually increased over time (Table 1). Adiponectin decreased only at 16 weeks of HFC feeding. Of the chemokines tested, MCP-1 (CCL2) was elevated throughout the observation periods in the HFC-fed mice; KC levels although higher than those of the chow-fed mice were not significantly elevated until 26 weeks post-HFC. Of the pro-inflammatory cytokines measured, IL-6 showed a modest increase at 16 and 26 weeks post-HFC. We did not obtain appreciable increases in circulating levels of GM-CSF, TNF-α, IL-12p70 and IL-1β in these HFC-mice. Serum amyloid A (SAA) levels were variable at 6 and 16 weeks post-HFC but were significantly elevated in the HFC-fed mice at 26 weeks post-HFC. IL-10 levels were increased in the serum of the HFC-fed mice at 16 weeks but were highly variable. At 26 weeks, IL-10 levels were more consistently elevated over the chow-fed controls. These measurements over the course of HFC feeding demonstrated that there was an inflammatory milieu in these mice.
Histological analysis reveals hepatic steatosis and inflammation in HFC-fed mice
Gene expression profiling reveals profound inflammatory gene regulation specifically in adipose and liver tissues of HFC-fed mice
To study the molecular mechanisms and pathways underlying chronic inflammation and insulin resistance, we utilized a custom-designed gene card to perform Taqman Low Density Array (TLDA) with multiple tissues taken from HFC- and chow-fed mice. We used previous comparisons to validate the results from TLDA by conventional quantitative real-time RT-PCR which then allowed us to choose TLDA as a high throughput assay for multiple gene expression profiling throughout this study. The gene card contains 92 unique genes chosen from their known functions associated with macrophages, adipokines, cytokines, chemokines, insulin signalling, endoplasmic reticulum stress, and glucose, lipid and energy metabolism (see Additional File 1 for details). The overall gene expression profiling reveals profound gene regulation in epididymal adipose tissue, mesenteric adipose tissue and liver (summarized in Additional File 2). There was either minor or no change of these genes in blood cells, muscle, pancreas, spleen and lymph nodes, based mostly on the results from pooled RNA samples (see Additional File 3). Our gene expression profiles in adipose and liver tissues established that there is a definitive presence of macrophage infiltration and inflammatory signals that is induced by obesity in HFC-fed mice. Here, we describe differential regulation of several groups of important genes involved in chronic inflammation and insulin resistance in adipose (epididymal and mesenteric fat pads) and liver tissues.
mRNA levels of genes involved in macrophage recruitment are strongly upregulated early in adipose tissues and progressively switched to liver of HFC- fed mice
The strong upregulation of mRNA levels of these genes in adipose tissues at 6 weeks was mostly decreased when the duration of HFC feeding increased to 16 weeks and 26 weeks. The dramatic decrease of relative mRNA level (fold change) at 16 weeks resulted from a decrease of mRNA levels in the HFC group and a concomitant increase of mRNA levels in the chow group. Intriguingly, mRNA levels of these genes were highly upregulated in liver at 16 weeks and even further increased at 26 weeks of HFC feeding (Figure 3). This is the first finding of significant gene regulation in the liver of these obese mice.
HFC diet induces macrophage infiltration and accumulation in adipose and liver tissues
mRNA levels of pro-inflammatory cytokine genes are differentially upregulated in both adipose and liver tissues of HFC-fed mice
Our work on gene activation in the HFC-fed mouse model is an attempt to accurately predict the sites of drug intervention and to possibly discover new targets in the mechanisms leading up to the induction of overt NASH disease. This paper describes a kinetic study for the direct temporal and spatial comparison of gene activation in a variety of organs as compared to age-matched chow-fed controls. First, a time dependent, diet-induced development of liver histopathology reminiscent of NASH, including steatosis, fibrosis and inflammatory infiltrates, was observed in the animal model used in our study of gene expression. Analysis of temporal inflammatory gene expression in multiple organs was carried out by TLDA. The epididymal adipose, mesenteric adipose and liver tissues show definitive time-dependent gene activation. In particular, those genes representing inflammatory mediators change dramatically over time. Gene activation to a various degree was also observed in other organ systems such as the blood cells, spleen, lymph nodes, gastrocnemius muscle, or pancreas but these gene patterns do not appear in any discernible pattern that would impact the induction of liver disease.
We report here that gene activation occurs early in the epididymal adipose with the peak activation at 6 weeks post-HFC. This activity in this particular adipose tissue is followed by a definitive increase in inflammatory signals in the liver at 16 weeks and 26 weeks post-HFC feeding. On the contrary, activated genes were downregulated in the epididymal fat pad at these later time points. This switch in activation profile from epididymal adipose tissue to liver as determined by quantitative RT-PCR was corroborated by the finding that there were significant increases in CD11b+ or CD11c+ macrophages in the liver at 16 weeks and 26 weeks post-HFC as well as by an increased accumulation of fatty droplets in the liver. These "activated macrophages" were not seen in the 6 week HFC livers when evaluated versus age-matched chow-fed control mice nor were there as many fatty droplets at this early time point. This increase in cellularity in the liver also appears in human disease. Genes involved in monocyte/macrophage recruitment are over-expressed in the livers of insulin-resistant human patients  and it is well-established that macrophages will accumulate both in adipose and liver under the influence of inflammatory signals [15, 16]. Furthermore, the reduction in gene activation observed in the epididymal adipose tissues at the later time point was accompanied by a decreased number of macrophages in this fat pad at 26 weeks post-HFC. These data suggest that a trigger for induction of inflammation was first set off in the adipose tissue and then sent out to other organ systems as fat feeding continued over time. This adipose-initiated signal sets up a process which results in overt liver disease by 26 weeks.
TLDA results of the mesenteric adipose tissue from HFC-fed mice indicate that inflammatory mediators and cell activation signals are also induced in this fat depot. This adipose tissue, however, does not appear to shift as dramatically in gene activation profile as that of the epididymal fat pad. This continual generation of cytokine and mediator gene signals found within the mesenteric fat amplifies the shift toward enhanced gene activation of the liver in these HFC-fed mice. It has been reported that the omental fat pad in obese humans can serve as a steady-state generator of inflammatory mediators which will then impact the development of disease .
Within the panel of genes included in our analysis, which ranges from metabolic to cellular markers to inflammatory mediators, IL-1β is identified as one of the most relevant inflammatory mediator as the disease induction process shifts from the inflamed epididymal adipose tissue to the liver. This enhanced IL-1 signal is relevant to current research findings in human metabolic disease. In obese patients, mRNA levels of IL-1 receptor antagonist (IL-1Ra) and IL-1 receptor type 1(IL-1R1) are markedly upregulated in white adipose tissue. In addition, IL-1β gene expression was selectively increased in the visceral fat (but not subcutaneous fat) from obese subjects . In patients with type 2 diabetes, the use of Anakinra (IL-1Ra) improved glycemia and beta-cell secretory function and reduced markers of systemic inflammation (CRP, IL-6) . Recent positive clinical results from a small trial with high affinity anti-human IL-1β (XOMA 052) also support targeting IL-1β mediated inflammatory damage to pancreatic beta cells as a potential therapeutic approach for type 2 diabetes . The use of TLDA technology applied to this mouse model can reveal further activated or dysregulated gene signals that will be relevant to human disease.
Excessive pro-inflammatory stimulation enhances the development of steatosis and NASH. In patients with acute and chronic liver diseases, production of IL-1 alters as the liver disease shifts in intensity from acute to chronic cirrhosis . At present, it appears that a certain mix of cytokines plus a genetic predisposition to hepatic immune defects may be needed to facilitate progression of NASH to cirrhosis . Our work demonstrates that there is very strong and relevant cross-talk between organ systems of the adipose tissue and the liver in our HFC mouse model which is also dependent upon the genotype of the mouse . Use of the TLDA technology to track gene changes over a time line will help to unravel some of this immune conversation and to identify whether new therapeutics can make these gene signals quiescent.
In the present study, we utilized the mouse model with a diet containing 45% fat and 0.12% cholesterol (as found in the Western diet) to investigate the molecular signals that trigger insulin resistance, hyperinsulinemia and progression to liver steatosis and fibrosis in the diet-induced obesity (DIO) mouse model. We used a sensitive and high throughput technology, Taqman Low Density Array (TLDA), to study gene expression profiling of 92 important genes representing macrophage-associated, inflammation-related and metabolism-driven genes in multiple tissues at 6 weeks, 16 weeks and 26 weeks post high fat and cholesterol (HFC) feeding. We demonstrate from our analysis of the gene activation profiles that macrophage infiltration accompanied by severe inflammation and metabolic changes occurs in both adipose and liver tissues with a temporal shift in the levels of these signals depending upon the duration of HFC feeding. This gene activation initiates early at 6 weeks post-HFC feeding in epididymal adipose tissues. Activation signals then switch to the liver at 16 and 26 weeks post-HFC feeding. These findings of time dependent development of steatosis in the liver are supported by immunohistochemistry. Taken together, the evidences of gene expression profile, elevated serum alanine aminotransferase, increased liver to body weight ratio, and histological data support a progression driven by diet-induced inflammation towards nonalcoholic fatty liver disease and even nonalcoholic steatohepatitis in these HFC-fed mice within the time frame of 26 weeks.
taqman low density array
high fat and cholesterol diet
interleukin 1 receptor antagonist
tumor necrosis factor-α
transforming growth factor β-1
nonalcoholic fatty liver disease
granulocyte macrophage-colony stimulating factor
monocyte chemoattractant protein-1
chemokine (C-C motif) ligand 2
chemokine (C-C motif) receptor 2
intercellular adhesion molecule 1
vascular cell adhesion molecule 1
matrix metalloproteinase 12
TNF-α converting enzyme
serum amyloid A.
We would like to thank Drs. Daniel Lundell, Timothy Kowalski, Eric Gustafson, Margaret van Heek, Joyce Hwa, Jean Lachowicz, Marvin Bayne, Hong Lan, Joseph Hedrick, Chuan-Chu Chou, Denise Manfra, Ethan Grant, and Qing Zhang for their support and advice. We also like to thank Rui Yu for her technical support. The study and manuscript preparation is supported by Schering-Plough Research Institute now Merck Research Laboratories.
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- Morgan K, Uyuni A, Nandgiri G, Mao L, Castaneda L, Kathirvel E, French SW, Morgan TR: Altered expression of transcription factors and genes regulating lipogenesis in liver and adipose tissue of mice with high fat diet-induced obesity and nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 2008, 20: 843-854. 10.1097/MEG.0b013e3282f9b203.PubMedView ArticleGoogle Scholar
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Large Square cutting board- with turquoise pool
This is a the second to the large size cutting board designed and made by Allegra Howell. Allegra is very dedicated to recycling, repurposing and reusing; so the majority of the wood in her cutting boards is recycled. These large square boards are roughly 12 inches squared. They all have a thumb hole making them easy to carry and hang. This is a beautiful cutting board, great for everyday kitchen use. Allegra builds these cutting boards to last. Each board is made of the hardest woods and 20 years of expertise craftswomenship. Each cutting board is different, and you will receive the exact cutting board in the picture with care instructions.

domain: artistic


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“The King will reply, “Truly I tell you, whatever you did for one of the least of these brothers and sisters of mine, you did for me.” Matthew 25:40
In honor of Father’s Day, we are featuring adoptive and foster dads on our Orphans No More podcast throughout the month of June.
This week on episode 277, host Sandra Flach talks with her favorite adoptive dad—her husband of 34 years, Wayne Flach.
Sandra and Wayne unknowingly began their adoption journey in 1999 when they opened their home to an eight year old relative. A few years later, that placement turned into a kinship adoption. In 2007 the Flach’s welcomed home a sibling set of three from Ukraine followed by a forth sibling in 2010.
Sandra’s book “Orphans No More: A Journey Back to the Father” releases everywhere 6/15, but you can order your very own signed copy now HERE. Please be sure to subscribe to the podcast, leave a review, and share it on your social media.
Links mentioned in this episode:


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Monday, April 20, 2009
Into the Wild
"There was a boy, a very strange enchanted boy...", so began a song written in the wartorn 40s, which tells a fantasy of a boy who "wandered very far, over lands and seas" only to learn that "the greatest thing... was just to love and be loved in return". The song could very well have been about Christopher McCandless, whose story has haunted me ever since I caught the movie Into the Wild.
Uneven at times and beautiful in parts, it tells the tale of a boy who hails from middle-class America, but found himself in spiritual discord with the excesses of modern times. To him, a career is a 20th century invention--smart suits, sharp ties, empty souls--and he didn't want anything to do with them.
Paraphrasing Henry Thoreau, he said, "Rather than love, than money, than faith, than fame, than fairness, give me truth." After fulfilling the tedious and absurd duty of graduating from college, he set off on a journey to seek his truth. Starting from Atlanta, he crossed the great American plains, worked his way to Nevada, and into Mexico via the Gulf of Mexico, and crossed the desert back to the US. Having gained an intimacy with the North American continent, his wanderlust now took him to the ultimate wilderness frontier: Alaska. Trekking alone into the Great White North, the wilderness finally caught up with him and, remorselessly, claimed his life. He got himself killed all because he refused simple navigational tools like maps and compass. The tragedy was not that he seemed so lacking in basic sense that he somehow threw away a life like that. Thousands of nutcases get themselves bumped off the gene pool all the time. The tragedy was he was otherwise a very competent and intelligent guy, fleet of foot and quick of reflexes, and he should never have died under the circumstances.
The director was rather heavy-handed in trying to explain the inner soul of Christopher McCandless, alluding often to his overbearing father and the dysfunctional element which ran in his family. While no doubt he had to escape his life because his family embodies all that he hates about society, I think the director is missing the point. It is simply the call of the wild. The same siren song which led Columbus to the Americas, Marco Polo to the far east, and Dr Livingstone to the heart of Africa. The wild promises adventures that enrich your life, a spiritual reunion with the earth, and a peace that simply cannot be gotten from our modern-day jungle. It stirs you alive. All I know is when the siren song of the wild beckons, I have to go.
Barry Lopez, a landscape photographer who writes for National Geographic, and who too had found his calling in wilderness attributed it to a sense of loneliness. He writes, "The cure for loneliness, I have come to understand, is not more socialising. It's achieving and maintaining close friendships. The trust that characterises that kind of friendship allows one to be vulnerable, to discuss problems that resist a solution, for example, without having to risk being judged or dismissed. I bring this up because the desire I experience most keenly, when I travel in landscapes like the ones made so evocative here, is for intimacy. I have learned that I will not experience the exhilaration intimacy brings unless I become vulnerable to the place, unless I come to a landscape without judgements, unless I trust that the place is indifferent to me. The practice I strive for when I travel is to meet the land as if it were a person. To encounter it as if it were as deep in its meaning as human personality. I wait for it to speak. And wait. And wait."


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Jemma Redgrave Pulls Out of Morrissey Macbeth
In a statement today, Bodinetz said: “We are terribly sad to lose Jemma and she leaves the rehearsal room with our very best wishes. In Julia, we are blessed with a wonderful actress who I have no doubt will give us a powerful and electrifying Lady Macbeth. David, the company and I very much look forward to welcoming her into rehearsals”.
Macbeth, which returns Morrissey to his home town of Liverpool and the theatre where he started his career as a member of the Everyman's youth theatre, was also due to mark a return of sorts for Redgrave, whose previous stage credits include The Great Game and Major Barbara. Last year, she withdrew from the premiere of A Thousand Stars Explode in the Sky, also citing personal reasons, following the death of her actor-father Corin Redgrave.
Julia Ford joins rehearsals immediately. Originally from the North West, Ford’s many credits include The Life of Galileo, Piano, The Crucible, Yerma and School for Wives at the National. She was most recently seen in Mogadishu for Manchester's Royal Exchange and London’s Lyric Hammersmith. Her television credits include Law & Order, Being Human, Red Riding Trilogy and Shameless, and she played Sandra Woolley in Shane Meadows' breakthrough film A Room for Romeo Brass.
Morrissey and Ford are joined in the Macbeth by Mark Arends, Ken Bradshaw, Richard Bremmer, Neil Caple, Matthew Flynn, Gillian Kearney, Syrus Lowe, Gavin Marshall, Shaun Mason, Nathan McMullen and Eileen O’Brien. The production is designed by Francis O'Connor, with music by Peter Coyte, lighting by Colin Grenfell and sound by Fergus O'Hare.


The video for Ciara’s first single, Never Ever, from her long awaited Fanatsy Ride cd will premiere January 31st on Yahoo Music. The video was directed by Chris Robinson and was recently shot in Atlanta, Georgia. Featuring Young Jeezy, Never Ever is the second single from Ciara’s Fantasy Ride and was recently released to radio stations across the country. The digital release is set for February 3rd and will coincide with the release of another Ciara single- Takin’ Back My Love- which features Latin singer Enrique Iglesias. The singer was recently spotted shooting the video for this single as well. Check it out on the next page- along with the official cover art for Never Ever.


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Soooo many items.
Atheon is done for.
Borderlands knew about Destiny's Loot Cave before they did.
This is exactly why we can't take anything these people say seriously.
Look at me. Being a Nintendo fanboy and a Gamergate supporter in one post. Multitasking at it's finest.
A Comic Explaining The World of The Introverts
Dad Finds The Best Way to Keep His Kids Busy For a While
Hey, They Save You The Cost of Buying Some Expensive Toy
A Dubstep Street Performer Meets His Match in This Passerby
Only in College...
Redneck Engineering: It's Not Dumb if it Works
German Shepherd Hilariously Wakes Up from Deep Sleep
This 11-Year-Old is Hiding a Cool Talent
If Comic Creators Could See Their Characters Now
Pick Your Site Name
Tell me more

domain: entertainment


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Your dog is barking because she is bored to tears. Either get another dog to play with her during the day, or reconcile yourself to a lot of walking before and after work. A tired dog is a good dog. Dogs need exercise so they're good and tired when the rest of their pack is away. If you can't do that yourself, can you maybe hire a walker to do it for you? Even a teenager who can come over before or after school would help.
we do walk her before...and then play with her when we get home. We couldn't have her doing too much because of the stitches in her paw, but they came out yesterday. We're trying to find someone to come by to take her for a walk but we've been unsuccessful so far, but it really hasn't been long.
Be careful if you get a second dog, 2 dogs are not necessarily better than one. We tried that and our barking dog is worse!!

domain: pet


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The VentureFizz Podcast: George Colony - Founder, Chairman, and CEO of Forrester Research
George originally started Forrester out of his basement, and the company has gone on to become one of the world’s most influential market research and advisory firms. Forrester went public in 1996, and is still traded on the Nasdaq today.
George is also involved as the founder of a new startup called Your Call Football, which is modernizing the game of football by giving fans the chance to influence a live sporting event in a real-time competitive gaming experience. Your Call Football actually just completed a very successful inaugural season.
In this episode, we cover:
- George’s participation in the World Economic Forum in Davos
- The story of Forrester
- How an interview with former NFL Commissioner Paul Tagliabue led to the a-ha moment of Your Call Football
- All the details on getting a new football league set up for its inaugural season, plus the future of the company and technology
- And of course, lots of useful advice for entrepreneurs!

domain: sports


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TV Review: ‘I Know This Much Is True’ is a standout ballet of duality
I Know This Much Is True tells the story of the Birdsey twins Dominick and Thomas and how the latter’s diagnosis of Paranoid Schizophrenia had a ripple effect on anyone they came in contact with. Dominick attempts to rationalize what is happening with his brother and overtime realizes that some things defy explanation. It’s this inability to rationalize what was occurring that propelled him down a dark and often inescapable hole. There comes the point where Thomas becomes his shield for addressing his tragic reality.
Riddled with dramatic tension, I Know This Much Is True is highlighted by a career-defining performance from Mark Ruffalo. This six-part series based on Wally Lamb’s critically acclaimed novel starts on HBO May 10th. The subject matter is extremely difficult to stomach, and at times audience members will have to fight urges to look away. Writer/Director Derek Cianfrance (Blue Valentine and The Place Beyond The Pines) is charged with adapting Lamb’s 900-page novel for this series.
Cianfrance stays true to Lamb’s narrative structure, rarely deviating from its structure. What is problematic in the series, however, is Lamb’s overabundance of exposition. While I’m sure that Lamb and Cianfrance felt it was essential to show Dominick’s twin brother slowly slipping into madness, those moments become anchors tied around the narrative’s momentum. Cianfrance also relied a little too much on unpacking the relationship the brothers had with their stepfather while in the book, Lamb doesn’t go into great detail.
Ruffalo and Kathryn Hahn (who plays his ex-wife Dessa) are fantastic in the series and easily have my favorite storyline centered on redemption. While most of the praise for the series will focus on how the veteran actor was flawless as Thomas, Hahn’s portrayal of Dessa brought the best out of Ruffalo’s Dominick and likely will be what puts him over the top in the mind of Emmy voters.
There’s no question that these two love each other even after going through an unspeakable tragedy. Still, it’s the nuance that Hahn brought to Dessa crying out for help from Dominick, which made the decision he makes unfathomable. While Thomas was born with his issues, his decision to betray his wife nearly lead him into a similar circumstance as his brother. The ability to trace this tragedy back to its origin is what makes the series so brilliant. My concern is, will people stick through the lengthy and unnecessary elements of the story to see this.
Melissa Leo plays Dominick and Thomas’s mother in the series and is fabulous. The mystery surrounding who the boy’s father was is certainly front and center in both the book and the series. Dominick’s lack of an identity eats at him and causes him to question his self-worth. Did his father not think his two sons were worth his time and energy? Leo’s character attempts to defend Thomas from the harsh reality of the real world, which seems only to delay what was inevitable.
Rosie O’Donnell plays Thomas’s social worker Lisa Sheffer and is dynamite as well. Sheffer ends up playing an integral part in Dominick coming to accept Thomas being placed in a state ran the facility and his eventual release months later. Sheffer’s presence cause Dom to check his emotions at the door and allowed rational thought to dictate their next moves.
While at times I Know This Much Is True has pacing issues, the camera work from Jody Lee Lipes captures the beauty of their surroundings while dialing up the perfect close-up at just the right time to show the anguish Thomas was going through in a given moment. Ruffalo and Hahn make this series worthwhile, but the overabundance of exposition from the source material slows this story down to a screeching halt.
I Know This Much Is True begins May 10 on HBO.


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Stress Management: What You Should Know About Alcohol, Tobacco and Other Drugs..When You Are Feeling Stressed
STRESSED OUT?
Is alcohol, tobacco and another drug one of your tools to help calm things down?
Rethink…are you helping or increasing your stress?
Office of Health Education and Promotion, Health Services
University of New Hampshire
www.unh.edu/health-services
Facebook/Twitter: UNHHealth

I feel clamer when I smoke or chew tobacco.
FACT:
Nicotine is a stimulant. Instead of calming you down it is actually speeding up bodily functions.
Sometimes when people are dependant on nicotine, smoking or
chewing does seem to calm them down, but really the feelings of
stress are being caused by withdrawal. As nicotine leaves the body,
withdrawal kicks in, increasing stress and anxiety. Then the person
uses nicotine products to relax. It seems that nicotine helped but
really the feelings of withdrawal are subsided for the time being.
Unfortunately, those feelings will be back and the person will need
more nicotine.

Nocotine can also impact ….
sleep patterns, which can increase
stress.
and
immune systems which can increase a
person’s chances of getting sick.

I know misuing drugs may be harmful but it really does seem to relieve stress.
FACT:
Some drugs affect the brain the same way stress does. Long-term drug use makes the users more sensitive to everyday stress than non-users.

I use drugs occassionally when I am stressed out – it is not like I use all the time. How bad can that be?
FACT:
There are several reasons why using drugs to handle stress can lead to problems.
Drugs can often have the reverse effect than expected, therefore increasing stress levels.
Drugs can affect sleep and eating patterns which can actually increase overall stress.
Stress can put people at risk for substance abuse, especially if using drugs to off set the stress.

I find having a few drinks relaxing.
FACT:
Alcohol relaxes people due to its depressant qualities.
Women and men can have 1 – 2 drinks, per day and not be negatively impacted physically by that amount. Some may actually see a health benefit.
But when people drink over these quantities, they risk a variety of impairment problems and unwanted consequences and also increase their stress levels.

About High-Risk Drinking
One night of high-risk
drinking may make the
stress seem better in the
moment, but the
causes of stress will
remain and may be
worse the next day.
High-risk drinking can
cause physical stress to
the body. It can take
up to 72 hours for the
body to repair itself
from a night of high-risk
drinking. In the
meantime, the causes
of stress may continue.

About High-Risk Drinking
Drinking may help you
fall asleep but it will
disrupt impair
sleep which can
increase stress the next
day.
High- risk drinking can
decrease the immune
system, making it more
likely that you will get
sick.
Research has shown that when one is experiencing highly stressful events (a death, sickness, breakup) this can influence their use of alcohol. When alcohol is used in these situations the more likely it may be that people will develop patterns of drinking that can be difficult to change later on.

All stress is bad for you.
FACT:
Stress can help you deal with tough situations. It can also be used as a motivator to finish projects, a paper, or study for an exam.
Stress can also be associated with positive changes such as starting school, a new job or deciding to study abroad.

Build Your Stress Toolbox
Learn how to manage stress and leave alcohol, tobacco and other drugs out!

Take a nap
Learn stress management techniques with a Wellness Educator/Counselor at Health Services (862-3823)
Or use any other tool you find relaxing and that will put you in the right frame of mind to tackle your next task.

The Office of Health Education and Promotion, Health
Services offers the following services to help you manage
stress:
- Stress management education/counseling
- Alcohol, tobacco and other drug education/counseling
- Individual and group meditation sessions
- Biofeedback
- Massage therapy
- Check out books, videos and CDs on a variety of
 wellness topics from the Resource Library
- And more…!
(603) 862-3823
www.unh.edu/health-services
Resources at UNH

domain: medical


text:
Good news! Los Angeles isn't so expensive after all, according to a Laguna Hill-based company called Geo-stat Advisory. According to their research, home prices in the Los Angeles, Long Beach and Glendale metro area are currently overvalued by just 2.7 percent. That's nothing! Homes are overvalued by 6.7 percent in Riverside, Ontario and San Bernardino county areas. There's no explanation of how the study was done, by the way. But no matter. All is ok in LA's market, according study author Nima Nattagh.
"I think the extent of overvaluation is not as much as some people have expected," he said. "I think it bodes well for the market."
Nationwide, Pittsburgh leads the country--overvalued by 25.7 percent, Geo-stat said. The most undervalued market is St. Louis at 28.4 percent, so get packing Riverside.
· Reality bites real estate market [Daily News]


Join the list to get a free download of 'A Leaving Song', now:
US release date: January 11th, 2011
"It is an elegant and, quite frankly, utterly beautiful record." NME, 8/10
We are excited to announce the forthcoming Broken Records album for release in January. Let Me Come Home is the band's second album - the follow-up to 2009's Until The Earth Begins To Part. Listen to A Leaving Song now!
Let Me Come Home started out as a series of sketches and song fragments in frontman Jamie Sutherland's kitchen, later taking form in demo sessions at an old distillery grain store in the Scottish Highlands. Recorded and produced by Tony Doogan (Mogwai, Delgados, Belle & Sebastian) at his Studio in Glasgow with artwork conceived by Vaughan Oliver at V23, Let Me Come Home will be released on CD, LP and digital formats.
1. A Leaving Song
2. Modern Worksong
3. Dia dos Namarados!
4. The Motorcycle Boy Reigns
5. A Darkness Rises Up
7. I Used To Dream
8. You Know You're Not Dead
9. The Cracks In The Wall


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Letters to Tiptree Paperback – August 24, 2015
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This book centers around a collection of—quite literally—love letters from current SFF writers addressed to Sheldon/Tiptree in various sets of her identities, and explaining what her existence, her work, her reception, and her struggles meant to them personally. The next, shorter section includes several sets of correspondence between Sheldon/Tiptree and some of her closest correspondents at the time the identity behind her nom de plume became public. That is, these are the letters where Sheldon identifies herself as Tiptree to Ursula K. LeGuin and Joanna Russ, sharing her fears that the revelation will destroy their friendships, and then the return letters from those writers, embracing and supporting her, and their continued correspondence in the aftermath. And finally there is a collection of introductions from collections and editions of Sheldon/Tiptree’s work after that time, discussing the literary and gender politics that Sheldon/Tiptree’s existence and reception revealed, at a time when data from that sort of controlled social experiment could have the greatest impact on the field. Also included are more recent academic papers looking back on her legacy.
This is not quite a work of literary scholarship, neither is it a work of biography. It is, as I say, pure love letter. As such, it supplies an essential completion to an understanding of Sheldon/Tiptree’s place in the field and her impact on readers and writers that goes beyond the sheer excellence and brilliance of her writing.
I didn’t have the experience of the dual-vision of Sheldon/Tiptree that is recorded in the latter parts of the collection (and some letters in the first part). The exposure of her identity occurred right around the time I was starting to pay attention to authors (as opposed to simply reading every book in the SFF section of the library). But I remember vividly reading some of her work in the late ‘70s and early ‘80s when all this was going down and feeling that sense of frustrated kinship of what it means to have to re-invent and mask yourself to have your work judged on anything resembling an even playing field. It's also daunting to consider how little we've moved beyond the day when an author who is--or is believed to be--male will have their work treated as cutting-edge and groundbreaking, when the same work written by an author who is (or is believed to be) female can have it dismissed as "women's writing" and self-indulgent. And yet, to set Sheldon/Tiptree aside as simply unequivocal and incisive proof of that phenomenon would be to buy into a notion that her body of work exists as commentary, as meta-text, rather than as something that should be read, evaluated, and honored for its objective brilliance.
So I feel a bit weird that this "review" is more meta-text commentary than a discussion of content. Let's just say that this is a valuable and fascinating celebration of the work and lessons of a great writer.
Letters to Tiptree is divided into several sections. The first and largest consists of letters written for this collection by authors, academics and fans to Alice, Tiptree and/or Raccoona. There is an impressive diversity of voices here, containing writers of varying backgrounds, nationalities, races, generations, gender identities, sexualities and classes. This diversity serves to showcase the wide impact Tiptree's work had--and continues to have--upon the speculative fiction community. But letter writing--even when the letters remain unanswered--remains a two-way street. I found myself equally as fascinated by what the letters revealed about their writers as what they said about Tiptree. Some clearly had an eye towards their audience, while others were more focussed on the person they were writing to. Some letters were restless and unhappy, while others were breathtaking in their sincere gratitude. Even the anger present in some merely added to the sense that this collection was a beautiful love letter.
Gender and identity are naturally one of the major preoccupations of these letters. It was interesting to see the different conclusions authors came to while pondering what ground--if any--feminism has gained since Tiptree's death thirty years ago. However, this wasn't the sole focus of these letters. They also dwelt on some of the other overarching themes of Tiptree's work, such as class, colonialism, technology and time.
The second section is formed of a selection of letters exchanged between Alice Sheldon and her contemporaries--specifically Ursula LeGuin and Joanna Russ. Sheldon had been writing to these two women under the guise of Tiptree and had formed close friendships with them. When the death of Sheldon's mother began to unravel the identity of James Tiptree, Jr., she was quick to write to them and confess the truth. The letters included in this book centre around these confessions. After hearing so much about the influence of Tiptree on the letter writers of the first section, it was a delight to hear her speak in her own voice. At the same time, it was a little bit heartbreaking because her fear and unhappiness are very evident.
This is followed by a section with a more academic focus, containing a few anthology introductions and excerpts from more scholarly works. I'd been able to grasp much of the context of Tiptree's work from the letters in the first section, though this did a good job of filling in some of the gaps and expanding the territory a little bit. I found Wendy Guy Pearson's 1999 paper on Tiptree as a transgender writer to be particularly interesting.
The collection was rounded out with letters from the two editors addressed to Tiptree and reflecting on their experiences of putting the collection together.
If the aim of the book was to interest new readers in the life and work of Tiptree, it succeeded in my case.

domain: library


After nine years, New York's Oneida and Herkimer Counties may finally get a landfill — if war veterans in Ava, N.Y., are not successful in their protest. As early as this fall, the New York State Department of Environmental Conservation (DEC), Watertown, N.Y, will decide weather to issue final permits for a 200,000 tons per year landfill to be built 800 feet from the edge of a veterans memorial forest.
Oneida and Herkimer Counties started their landfill search in 1991, when they began to export waste to places such as Rochester, N.Y.
“The [Solid Waste Management] Authority Board wants to be able to control disposal costs which have been rising since 1991,” says Mike Wolak, director of engineering for the Authority.
Consequently, the Authority evaluated the soil and underground water and rock formations at 79 possible sites in the two counties, eventually selecting two locations. Then in 1994, after 44 public meetings, the Authority chose the Ava site because of its deep clay deposits and protective bedrock, as well as its location in a sparsely populated area, Wolak says.
However some Ava residents — including several veterans — are protesting the landfill because they are concerned about the possible environmental effects. They also say the landfill will dishonor the memories of war veterans.
On August 10, during two public hearings organized by the DEC, 57 people expressed concerns about the proposed landfill to an administrative law judge. Opponents are concerned about the projected 180-foot landfill height, as well as the threat of groundwater contamination, odor, birds and vermin. Only six people spoke in favor of the landfill. A representative from the U.S. Army Corps of Engineers, Buffalo, N.Y., along with Oneida County legislators and more than 500 concerned citizens, also attended the hearings.
However, the site's proximity to the veteran's memorial forest never influenced the Authority's decision, according to Wolak, who says that one of the original sites considered actually overlapped the forest.
In answer to the veterans' concerns, Wolak says that the trees between the veterans' forest and the proposed landfill will provide a visual buffer. To avoid groundwater contamination, the Authority will install a dual composite liner system above natural clay formations, as well as leachate collection pipes. Monitoring wells will be evaluated from now until 30 years after the landfill's closure.
Wolak says that the Authority will keep the landfill's active working face to a minimum and will install noise deterrents, litter fences and daily landfill covers.
But for Ken Martin, a retired Marine who heads the group Veterans Defending our Memorial Forest, these solutions offered by the Authority are not good enough.
Nevertheless, the veterans' last hope of blocking the permits is to convince the judge that the case requires further scrutiny. If the judge agrees, the issue will be adjudicated during the next few months. If not, the New York DEC Commissioner could issue final permits within days of the judge's decision.
At this point, the opposition must convince the judge that the proposed landfill would violate existing environmental and solid waste regulations, a difficult task considering that the DEC already has reviewed the Oneida County Waste Authority's environmental impact statement and determined it is acceptable.
Things do not look good for the opposition, according to Steve Litwhiler, citizen participation specialist for the DEC's Region 6.
“We have issued a draft permit because everything we see says that a landfill can be constructed [on the site] and would be environmentally sound, according to the state's solid waste regulations,” he says.
The protesters have received the support of the commander in chief of the national headquarters of the Veterans of Foreign Wars (VFW), Kansas City, Mo., and the national adjutant general. Martin believes these groups will provide pivotal support.


text:
Minister of Justice Tudorel Toader and the Ambassador of Spain in Bucharest, Ramiro Fernandez Bachiller met on Tuesday and discussed Romania’s preparation for taking over the presidency of the EU Council and the financing solutions for the penitentiary system, reads a press release of the Justice Ministry, sent on Wednesday.
Secretary of State Marieta Safta also attended the meeting on Tuesday.
“During the meeting, special attention was paid to Romania’s preparation of the Presidency of the Council of the European Union, the Spanish side presenting its 2010 experience, which could be capitalized by launching a technical dialogue on the model chosen by Spain and the registered results. The talks also focused on identifying EU funding solutions for the penitentiary system,” shows the press release.
According to the quoted source, the topic of financing the penitentiary system was addressed in the context of an action initiated by the Romanian and Italian Ministries of Justice and signed by 10 other EU ministers.
The two officials also highlighted the common desire to intensify cooperation between the two countries, especially on judicial co-operation and criminal reform, also by organising ministerial bilateral visits and initiating joint projects.
“The talks also referred to the Cooperation and Verification Mechanism (CVM), with the Spanish side expressing hope that MCV will be lifted before Romania takes over the Presidency of the EU Council, while stressing the importance of sustainability and irreversibility of the registered progress,” the release further mentions.

domain: news


text:
Hell Bunny 50s Style Bamboo Print Halterneck Cotton Dress
SALE - was £45 now £35
Lovely 50s style cotton dress with full circle skirt and a great tropical print with bamboo sticks, pink and purple flowers, and green leaves on a cream coloured background.
Adjustable halterneck straps and shirred back bodice. Secured with a rear zip. Can be worn with or without a petticoat.
Fit Advice: This style runs larger than normal due to the elasticated back on the bodice, therefore you may need a size smaller than normal.
Washing Advice: Machine washable
Fabric: 98% Cotton, 2% Elastane
Length: Knee Length
We Also Recommend

domain: design


Scratch programming for teenagers. One of the most popular courses at the GoMother IT school is children’s programming with Skrech. Parents do not always understand what kind of program this is. That is why we decided to talk a little about what kind of programming language it is, where it came from and how it helps children become IT people.
A bit of history Scratch for kids
The name Scratch itself comes from the word scratching – this is a technique used by hip-hop DJs that twist vinyl records back and forth with their hands (you could see this in old films or on the Internet, today DJs work with slightly different equipment). Scratch was created as a continuation of the ideas of the Logo language and the beloved Lego constructor. First, let’s clarify that it is written in the Squeak language. A small team of programmers from the Massachusetts Institute of Technology is working on Scratch. The current version is 2.0, released on May 9, 2013.
What is Scratch programming for children created for?
Scratch was specifically designed to help kids learn animation, games, music, and animated images in a simple and visual way. Its main advantage is that programs are not written in code, but are made up of multi-colored blocks. Each block is a function to which its parameters are added.
Thus, the child gets acquainted with the basics of programming, learns to decompose tasks into component parts and think through steps to solve them. He also learns important mathematical concepts such as coordinates, changing variables, random numbers. These basic principles will help as you continue to teach programming to children – on the basis of the established foundation, it will be easier to build an understanding of computer syntax and more complex functions.
Teaching programming for teenagers with Scratch
Once a student has mastered the basic tools and tools of Scratch, they can create a working prototype for any of their ideas. Further work is no different from what adult developers do: you need to look for the causes of errors that occur, come up with ways to optimize, consult with “colleagues” and help them with their problems.
This allows children not only to gain technical programming skills, but also to learn the development process from the inside. The educational process is built in such a way that young course participants can create, communicate, analyze and collaborate.
All these skills will be useful to them, even if they do not connect their professional life with IT. Teaching programming to children forms the right approach to problems and gives an understanding of the technologies that form the basis of the life of a modern person.
Course for a child: Scratch programming for teenagers
The best gift for a student for the New Year is definitely a programming course! We do not have a banal theory, but a fun practice! See for yourself, we are waiting for you online!


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Strukture presents : Funkagenda
December 20, 2019 @ 11:00 pm
If you don’t already know Funkagenda’s accolades include, Ibiza DJ ‘Best Ibiza Track’ and the Beatport ‘Best Tech House Track’ award for his ‘Man With The Red Face’ collaboration with fellow super producer, Mark Knight.
Funkagenda was also presented with the Ibiza DJ ‘Best Newcomer’ and DJ Mag ‘Best Breakthrough DJ’ awards for his solo achievements and regularly performed on the world’s leading broadcast station of electronic dance music, Radio 1!
Authenticity and cutting-edge originality are his trademark, establishing himself a solid reputation as an innovative DJ & producer as he consistently pushes the boundaries and pioneers the sounds of tomorrow, forever forging a loyal international following for his distinctive productions and stage presence.
EARLY BIRD TICKETS ON SALE NOW


text:
Craft beer fans rejoice: Upper Pass Beer is having their first 'Can Sale' this weekend!
If you are a regular shopper in South Royalton, you might have noticed that the sign "For Rent" in front of 228 Chelsea Street next to the South Royalton Market has disappeared. What used to be Bob-White Systems, then an art gallery for local artist Joan Hoffman, will be renovated and turned into a tasting room for coffee and a point of sale for beer. The company moving in is Upper Pass Beer, a local brewery based in Tunbridge Vermont.
Upper Pass Beer was started about 3 years ago, by Chris Perry and Andy Puchalik. Both avid homebrewers, they decided to team up to find a space suitable to brew larger quantity of beers. They found a place in the hills of Tunbridge, and released their first beer at the Tunbridge Fair in 2015. Ivan Tomek, a local orthopedic surgeon, joined their team, and Upper Pass Beer was born. "We are on tap at some of the best craft beer bars in the state, and our beer First Drop Pale Ale, which we brew up at Von Trapp [brewery in Stowe] is our first can release," Andy said. They started brewing at Von Trapp Brewery every month, "our own brewery was too small," he added. The plan in the next few years is to build a larger brewery, but as of right now, they are pouring their energy into opening the tasting room. "Ivan and I are still working almost full time jobs and have families," Andy said, spending any free time brewing beers. "Chris will be the one spearheading our beer delivery soon," he said. They are producing 100 barrels of their signature beer every month, and the demand is there. "We are getting great feedback," Andy said, adding that "First Drop is starting to become popular statewide."
Andy Puchalik explaining to my son what coffee beans are.
The tasting room in downtown South Royalton will be opening sometimes in 2017. "We still need to do a lot of work inside, and go through some paperwork with the state" said Andy. Their first Can Sale is this coming Saturday September 3, at their future shop in town from 10-2pm. They will be selling their beer called First Drop. They will also be giving a taste of their cold brew, First Branch, to the first 50 customers.
(Original title was supposed to be "Something is brewing in South Royalton!". But I refrained myself, and went for the boring title instead.)


text:
The Penguin division of Pearson PLC (NYSE:PSO) has announced today that they will be paying $75 million in damages along with costs and fees as part of a settlement with the United States government over an alleged price-fixing scheme related to the e-book market. Pearson is taking an extra provision on their accounts this year after setting aside $40 million in 2012. The company already reached an agreement with the Justice Department in the e-book case, but the latest deal settles the case with individual states in the U.S.
Last year, the Justice Department accused Apple and five e-book publishers of price collusion as a way to compete against Amazon.com’s e-book marketplace. The five publishers that were involved in that case included Simon & Schuster, Hachette Book Group, Penguin Group (USA), Macmillan, and HarperCollins Publishers Inc.
The book publishers did not like that Amazon.com was selling some of the best sellers for $9.99 to encourage consumers to buy the Kindle. The publishers feared that this model would lead to consumers getting accustomed to buying books for cheap.
Pearson denied any wrongdoing in the past in terms of e-book pricing, but they decided to settle so that they could move forward with the Random House merger. That merger was announced this past October.
Penguin also said that they committed to the state attorneys to abide by the terms agreed upon with the Justice Department.

domain: economics


Bronze Flexible Track Lighting | The growth of technology and demand for better light sources gave us LED lights. The sources have evolved from the traditional incandescent or fluorescent lights to LED. Compared to incandescent lights, LED lights contain the lighting consume 60% less energy and still provide similar brightness. The architects and interiors designers are having superior options with LED under cabinet lighting. They can now experiment lots of new looks because the LED under cabinet flexible strip may be operated on ultra narrow platforms. The LED strip lights may be installed anywhere without much of the trouble and produces warm or pure white light. They are extremely low profile and highly flexible being bent in different degree. The LED under cabinet lighting may be installed in a number of ways with the help of fixtures and provides a superior glowing effect within the surroundings.
See also: Lighting Over Kitchen Island Photos
The LED kitchen cabinet lights are trusted to further improve the feel of your kitchen cabinets. It is luxury form of LED lighting simply because they offer a completely new outlook to your kitchen cabinets. The contractors and architects today use variations within the lighting to give attractive look. It is available in vivid colors; hence they may be used to suit the mood better according towards the environment and color theme of the surroundings. They also provide facility being modulated; hence the brightness may be controlled. This complements the location which is illuminated thus went a step ahead when compared with xenon or incandescent lighting. The interior decorators use new & better options to decorate the home, office or hotels. Be it a book shelf, garden patio, kitchen cabinets or ceilings, LED has become their prime choice because of brilliant color combination, less heat generation and low consumption. The LED flexible strip lighting may be accommodated anywhere without much associated with an effort.


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White 150mm wall/ceiling exhaust fan with modern easy clean fascia, ball bearing motor and back draft shutter.
Versatile wall/ceiling/window slimline exhaust fan with compact body design. Ideal for small install spaces. Window kit and back draft shutter...


Smooth and Sporty | 2014 Kia Sorento LX
The 2014 Kia Sorento LX offers a more advanced performance than ever before. Choose between engines that offer better fuel economy, even more power, plus a choice of front-wheel and available all-wheel drive. Visit Kia West today and see what all the buzz is about.
New for the 2014 Kia Sorento LX are subtle changes to make this machine look better than ever. It comes with a thinner chrome trim, LED taillights and redesigned headlight clusters. The cabin of the new 2014 Kia Sorento LX is full of luxury and conveniences. It comes with clean lines, premium materials, bright accents, and ample storage. The Sorento LX also features a new age digital gauge that displays temperature, directions, mileage, fuel consumption and music choices.
The overall performance of the 2014 Kia Sorento LX has been improved thanks to Kia’s high engineering standards. The standard Sportmatic automatic transmission gives you the power be a force on the road without compromising fuel economy.
2.4L GDI Inline 4-cylinder, DOHC 4-valve CVVT 6-speed automatic : 191 horsepower and 181 lb-ft of torque
3.3L GDI V6, DOHC 4-valve CVVT 6-speed automatic : 290 horsepower and 252 lb-ft of torque
The 2014 Kia Sorento LX continues to impress consumers. It has been named AJAC 2014 Best New SUV/CUV ($35,00 to $60,000). It also has best-in-class safety features to keep you protected such as Electronic Stability Control, Hill Assist Control and multiple air bags.