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Over the past 2 decades, our understanding of the pathobiological events underlying chronic myelogenous leukemia (CML) has grown. At the same time, effective transplant and nontransplant treatment approaches to
Drs. Brunstein and McGlave present an outstanding review of the biology and treatment of chronic myelogenous leukemia (CML). Among hematologic malignancies, CML is unique in that it is consistently responsive to biological therapy. Furthermore, CML is a disease that highlights how an understanding of the basic biology of malignancy can translate into effective clinical therapy. The dramatic and rapid changes in our understanding of the biology of CML are best viewed with a historical perspective. Using this framework, we can trace the evolution of CML treatment and demonstrate how our new knowledge has led to the ability to cure this once uniformly fatal disease.
Chronic myelogenous leukemia has been a model for cancer biology since Nowell and Hungerford’s original description in 1960 of a "minute" chromosome in CML cells. This was the first consistent genetic abnormality to be linked to a specific tumor. In 1973, this "Philadelphia chromosome" was shown to be a shortened chromosome 22, the result of a balanced translocation between the long arms of chromosomes 9 and 22. By the early 1980s, it was known that this translocation resulted in the fusion of BCR and c-ABL, forming a chimeric BCR/ABL transcript. The BCR/ABL gene encodes a constitutively activated tyrosine kinase capable of transforming hematopoietic cells in vitro and inducing CML in animal models. These discoveries laid the groundwork for an entire field of cancer biology.
Allogeneic Stem Cell Transplantation
Despite the many advances in therapy outlined in this review, allogeneic stem cell transplantation remains the only known curative therapy for CML. Drs. Brunstein and McGlave discuss the role of allogeneic stem cell transplantation, but perhaps understate the contribution of the immunologic graft-vs-leukemia (GVL) effect. The donor graft itself provides a potent antileukemic reaction, independent of the conditioning regimen. Initially, evidence of clinical GVL activity was indirect and included several observations: (1) a graft-vs-host disease (GVHD) flare could induce remission in relapsed patients, (2) GVHD was protective against relapse, and (3) syngeneic marrow grafting markedly increased relapse rates in patients with CML.
Graft-vs-leukemia activity is mediated at least in part by donor T cells. In CML, relapse rates increase from approximately 10% after unmanipulated marrow transplantation to over 50% when donor grafts are depleted of T cells to prevent GVHD. Clearly, allogeneic stem cell transplantation represents an effective method of immunotherapy and is not simply a mechanism by which to administer higher doses of chemotherapy and radiation.
The first direct evidence of GVL induction in the clinical setting came with the use of donor leukocyte infusions to treat relapsed leukemia after allogeneic stem cell transplantation. Donor leukocyte infusion reestablishes complete remissions in over 60% of patients with chronic-phase CML. Furthermore, with a median follow-up of well over 3 years, more than 60% of patients enjoy sustained remissions after donor leukocyte infusion. The use of donor leukocyte infusion confirmed that allogeneic immunotherapy was extremely potent against CML and suggested that the contribution of the conditioning regimen to successful allogeneic stem cell transplantation in CML was perhaps overestimated.
This has led to trials using nonmyeloablative, immunosuppressive therapy followed by allogeneic stem cell transplantation in order to minimize conditioning regimen toxicity and maximize GVL activity. Several reports now suggest that this approach may be feasible for some patients with a variety of malignancies, including CML.[9,10] This represents a new paradigm in allogeneic transplantation whereby it may be possible (and preferable) to use less, rather than more, cytotoxic therapy. No doubt, future reports will continue to explore the potential of nonmyeloablative allogeneic cell therapy.
The development of STI-571 heralds another "first" in oncology: the rational design of targeted drug therapy at the molecular level. STI-571 inhibits the BCR/ABL tyrosine kinase, blocking the growth of CML cells in vitro and eliminating CML in mice. Preliminary clinical data show that hematologic responses are almost universal and cytogenetic responses are common; however, the durability of these responses will require additional follow-up. Nevertheless, the clinical application of this drug begins to close the circle that started with the earliest observation of an abnormal chromosome in CML cells, and has now led to therapy aimed at specific molecular targets.
Choosing Optimal Therapy
Drs. Brunstein and McGlave review the controversies surrounding the optimal choice of therapy for patients newly diagnosed with CML; their guidelines provide a reasonable approach to this challenging dilemma. Although there are many new effective treatment options, allogeneic stem cell transplantation is still our only chance for cure.
The timing of a transplant requires a particularly complex decision. On the one hand, most patients can anticipate several years of progression-free survival with good quality of life; on the other, stem cell transplantation is most effective when performed (1) within 1 year of diagnosis, (2) in younger patients, and (3) before progression of disease.
Figure 2 in the article by Drs. Brunstein and McGlave provides an excellent illustration of these concerns. Survival curves comparing stem cell transplantation to hydroxyurea (Hydrea) or interferon favor the nontransplant group for approximately 3 years after diagnosis, primarily because of the high treatment-related mortality associated with transplants. However, long-term survival is highest in the transplant group. Therefore, in a young patient with a matched sibling donor, early transplantation, within the first year of diagnosis, provides the greatest chance of cure. Ultimately, decision analysis will also have to consider less tangible factors such as quality of life, societal costs, and potential new therapies still in development (eg, CML-specific vaccines and the generation of tumor-specific immunity).[14,15]
Expanding the Donor Pool
Since approximately half of CML patients are under 50 years old, and only one-third will have a matched sibling, increasing the donor pool is a major goal for allogeneic cell therapy. Unrelated-donor stem cell transplantation is an important and effective option for patients who are under age 50 and have a suitable match. This therapy greatly increases the number of patients who can be offered potentially curative therapy. Dr. McGlave and his group have been leaders in the use of unrelated-donor stem cell transplantation for CML, and recent updates demonstrate that cure rates close to 60% can be anticipated (similar to results obtained with matched sibling marrow grafting). Furthermore, unrelated-donor stem cell transplantation within the first year after diagnosis maximizes quality-adjusted, disease-free survival.
Drs. Brunstein and McGlave provide a thorough discussion of CML, from its basic biology to the many treatment options. Chronic myelogenous leukemia is the first cancer in which an understanding of the molecular basis of the disease has led to new and effective treatment options. Furthermore, the use of allogeneic immunotherapy to treat CML demonstrates that it is now possible to harness the human immune system for clinical benefit. Undoubtedly, the lessons learned from the biology and treatment of CML will be applicable in other areas of cancer therapy.
1. Nowell PC, Hungerford DA: A minute chromosome in human chronic granulocytic leukemia. Science 132:1497, 1960.
2. Rowley JD: Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature 243:290-293, 1973.
3. Kurzrock R, Gutterman JU, Talpaz M: The molecular genetics of Philadelphia chromosome-positive leukemias. N Engl J Med 319:990-998, 1988.
4. McLaughlin J, Chianese E, Witte ON: In vitro transformation of immature hematopoietic cells by the P210 bcr/abl oncogene product of the Philadelphia chromosome. Proc Natl Acad Sci U S A 84:6558-6562, 1987.
5. Daley GQ, Van Etten RA, Baltimore D: Induction of chronic myelogenous leukemia in mice by the P210 bcr/abl gene of the Philadelphia chromosome. Science 247:824-830, 1990.
6. Horowitz MM, Gale RP, Sondel PM, et al: Graft-vs-leukemia reactions after bone marrow transplantation. Blood 75:555-562, 1990.
7. Kolb HJ, Mittermuller J, Clemm C, et al: Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 76:2462-2465, 1990.
8. Porter DL, Collins RH Jr, Shpilberg O, et al: Long-term follow-up of patients who achieved complete remission after donor leukocyte infusions. Biol Blood Marrow Transplant 5:253-261, 1999.
9. Slavin S, Nagler A, Naparstek E, et al: Nonmyeloablative stem-cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 91:756-763, 1998.
10. Champlin R, Khouri I, Komblau S, et al: Reinventing bone marrow transplantation. Nonmyeloablative preparative regimens and induction of graft-vs-malignancy effect. Oncology 13:621-628; discussion 631, 635-638, 641, 1999.
11. Druker BJ, Tamura S, Buchdunger E, et al: Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of bcr-abl positive cells. Nat Med 2:561-566, 1996.
12. Le Coutre P, Mologni L, Cleris L, et al: In vivo eradication of human bcr/abl-positive leukemia cells with an Abl kinase inhibitor [see comments]. J Natl Cancer Inst 91:163-168, 1999.
13. Druker BJ, Talpaz M, Resta D, et al: Clinical efficacy and safety of an Abl specific tyrosine kinase inhibitor as targeted therapy for chronic myelogenous leukemia. Blood 94:368a, 1999.
14. Choudhury A, Gajewski JL, Liang JC, et al: Use of leukemic dendritic cells for the generation of antileukemic cellular cytotoxicity against Philadelphia chromosome-positive chronic myelogenous leukemia. Blood 89:1133-1142, 1997.
15. Bocchia M, Korontsvit T, Xu Q, et al: Specific human cellular immunity to bcr-abl oncogene-derived peptides. Blood 87:3587-3592, 1996.
16. McGlave PB, Shu XO, Wen W, et al: Unrelated donor marrow transplantation for chronic myelogenous leukemia: 9 years’ experience of the national marrow donor program. Blood 95:2219-2225, 2000.
17. Lee SJ, Kuntz KM, Horowitz MM, et al: Unrelated donor bone marrow transplantation for chronic myelogenous leukemia: A decision analysis. Ann Intern Med 127:1080-1088, 1997.


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A central vacuum does not require regular servicing, however occasional maintenance prolongs the life of your system. Basic maintenance is described in your accompanying operating and maintenance manual.
Due to the reliability of our central vacuum systems, and despite being in the business for over 25-years we have never found it necessary to employ a full time nationwide service engineer. Maintenance or fault finding is usually easy and can be undertaken by yourself or any competent DIY’er using the instructions we provide.
Our Service and Support Options:
- A call out service – up to 2 hours of labour and does not include replacement parts
- Self diagnosis using the relevant do**censored**ent from our download section.
If your central vacuum is not picking up as well as it usually does, this will be due to one of two reasons: a blockage or a leak in the system. A blockage is usually as a result of debris building up behind a long object lodged in the pipe work which has been sucked up whilst vacuuming. All the attachments have been designed with a sharp 90 swivel neck and small suction aperture, this prevents long objects from going into the system. If an object gets past the first neck or aperture, it usually ends up in the sharp 90 coupling just behind the inlet. Most blockages are caused when the vacuum is used without an attachment. To unblock the system we use your central vacuum to reverse the suction. A leak in the system can be due to an inlet not closing properly or a vacpan (the kick plinth in the kitchen). Most customers who have worked through the trouble shooting for poor suction have been successful without the need for a central vacuum service call out.
As well as being the UK’s sole distributor for the Aertecnica and Duovac Central Vacuum Systems, we also service and support other central vacuums.
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You are watching: How many electrons are in a carbon atom
► more about the history and places to find carbon.► Next aspect of the regular table.
|Carbon DioxideThis is a carbon dioxide molecule. As soon as you breath out, you commonly breathe the end carbon dioxide. V the formula CO2 that way there space two oxygen (O) atoms and also one carbon (C) atom. If friend look closely at the period structure, you"ll see that castle share 4 electrons each. If a link shares two electrons that means it is a solitary bond. If a bond is consisted of of 4 electrons it is a dual bond. That method that the carbon atom has actually two double bonds, one with each oxygen atom.|
|Cyanogen ChlorideHere"s something new! We have actually three different facets here, carbon (C), nitrogen (N), and also chlorine (Cl). That"s no special, but the way they incorporate is! Look in ~ the carbon and the nitrogen, they room sharing six electrons!When two atoms share 2 electrons, that"s a single bond. If castle share 4 it"s a double bond. Well these two are sharing six, that"s a triple bond. It"s extremely strong and powerful. It would certainly take a most work to different the C and the N!One an ext thing! because the bond between carbon and also nitrogen is so strong, scientists speak to them "cyanogen" instead of carbon-nitrogen. Scientists know that cyanogen is constantly CN.|
See more: Does Pizza Dough Go Bad? How Long Can You Keep Pizza Dough In The Fridge ?
|Beryllium CarbideTwo beryllium (Be) atoms space able come bond with one carbon (C) atom to develop Be2C. The beryllium atom let the carbon use their electrons so that the carbon is "happy". Every beryllium offers up both of its two extra electron to the carbon. Take it a look and also see how all of the electrons room shared.|
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|Starts||13 Jul 2017 (Thu)||Ends||19 Jul 2017 (Wed)|
|SINGPromos is now on Telegram. Click here to follow us now|
The Mariner of the Seas is all set to take you on an adventure beyond your imagination!
Make your way down to Raffles City to find out more about the exciting treats and destinations she has to offer.
- Venue: Raffles City Level 1, Garden Court
- Date: 13 – 19 July, 2017
- Time: 10am – 10pm
Cruises listed are
- 3-Night Malaysia Explorer Cruise
- 4-Night Isles of Southeast Asia Cruise
- 5/7-Night Spice of Southeast Asia Cruise
- 7-Night Thailand and Vietnam Cruise
- 9-Night Exotic Asia Fly-Cruise
- 9-Night Hong Kong to Singapore Fly-Cruise
*Terms and conditions apply.
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NEW: Get a Samsonite Luggage Prestige 69cm Spinner Exp with built-in scale (worth SGD670) (with min spend of $800) plus no annual fees when you sign up for a HSBC Revolution credit card at www.hsbc.com.sg.

domain: travel


What a difference a few miles make.
That is especially true in northern Utah, where a few miles is making a critical difference between major water woes and having to put up with minor inconveniences this summer.The discrepancy is causing a lot of confusion in the public's mind. While some districts are pleading with customers for major water conservation efforts or are imposing mandatory watering restrictions, others are simply urging caution and moderation.
News reports on recent mountain storms significantly increasing snow pack over the past month add to that confusion, officials say. Indications are that much of the recent snow will not add significantly to earlier runoff projections. In other words, reservoir storage remains critically low throughout the state. Also complicating matters is Utah's water rights system, which gives the holder of senior water rights - many of which belong to irrigation companies - control over some reservoirs that are critical in the culinary water systems.
Providing irrigation and culinary water to cities and irrigators in Davis, Weber, Morgan and Summit counties, the Weber Basin Water Conservancy District has just 27 percent of its regular water supply to meet the needs of its customers this year, said district general manager Ivan Flint.
In addition to the lack of mountain snow and a fifth consecutive drought year, the Weber water district is plagued by the lack of senior water rights in a few of the seven reservoirs operated by the district on the Weber and Ogden rivers, he said.
Flint said the district is imposing restrictions that should give cities full delivery on culinary water contracts while restricting irrigation to 50 percent of contracted supplies. The district will be pumping all eight of its deep wells - a move that Flint admits could affect other wells in Davis and Weber counties - and it plans to make major water exchanges out of Willard Bay using a drought-relief pumping system built in 1977 but never used.
Explaining the need for these restrictions has been difficult, Flint said, because areas like Salt Lake City and Ogden, which hold senior water rights along the Wasatch Front's major watersheds, are not as heavily impacted and are not imposing similar restrictions.
"People just don't realize the difference that 10 or 20 miles can make," Flint said.
Those sentiments were echoed by others making water reports at the meeting.
Carly Burton, a Utah Power & Light spokesman, said water users dependent on Bear Lake water will face restrictions this summer. UP&L controls water flows at Bear Lake, which is operated as a reservoir for the company's hydro-electric operations.
Burton said letters have been sent to water users urging major conservation efforts. He said use of released water will be closely monitored and will be cut off in areas where it appears the use is not warranted.
"People don't realize that the net runoff we have received in Bear Lake from 1987 to 1989 was less than one year's runoff received during normal water years," Burton said.
Water availability differs
Where you live will have a big impact on how the current drought affects your water use:
- Bountiful City is imposing outdoor watering restrictions because of limited secondary deliveries from Weber Basin Water Conservancy District.
- In Salt Lake City, a few miles to the south, water districts have yet to impose water restrictions. With Deer Creek Reservoir, a major water source for the Salt Lake valley and one of the few largestrip
- Layton, in north Davis County, also faces severe limitations for outdoor secondary systems because of Weber Basin's dilemma.
- Ogden, a few miles to the north, is among the areas that receive much of their culinary supply from wells and should be able to meet traditional indoor water demands.
- Cities in Davis and Weber counties dependent on Weber Basin for culinary water supplies face the dilemma of choosing between maintaining current water department revenues or protecting reservoir st~


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Maseru, Sept. 09 — The Farmers Pitso presented awards to the farmers who have excelled in different fields of farming at a ceremony held at the ‘Manthabiseng Convention Centre on Saturday.
The Convention centre beamed with enthusiasm and jubilant as recipients of awards from the association in order to motivate the farmers.
The recipients of the awards included prominent farmers like Leader of All Basotho Convention (ABC), Mr. Nkaku Kabi, Lesotho National Wool and Mohair Growers Association (LNWMGA) President Mr. Mokoenehi Thinyane, as well as up and coming farmers from herders including a South African Merino and Angora goats farmer who provides the local farmers with technical knowledge and sell rams to them.
They were presented with awards and blankets including caps amidst dancing, singing and ululation as they went to the stage to receive the awards as a token of appreciation for their hard work.
Among the awards recipients included two members of the Lesotho Defence Force (LDF) Privates Rorisang Moepi and Dumile Ts’oeunyane who were once detained at Matatiele in South Africa for following on the stolen stock from Qacha’s Nek to South Africa.
They were presented with awards and blankets as well as two Lesotho Mounted Police Service officers Inspectors Ts’otleho Makhele and Mapuru Makhakhe for their sterling job in fighting stock theft.
Speaking at the event, Minister of Agriculture, Food Security and Nutrition Mr. Thabo Mofosi commended the Farmers Pitso Association for the initiative to recognise the farmers, saying that will motivate them to work even harder.
He noted that there is time for entertainment as well as time for work, promising that next time he will organise a gala dinner for the farmers in order to recognise their contribution to the economic growth and food security in the country.
‘Farming is not a business but a God sent call to those who are passionate about farming’ he highlighted.
The Minister made a promise to the farmers that next time, they will be able to buy homemade tractors and that there will be no need for them to go to neighbouring South Africa to buy them.
Mr. Mofosi noted that Prime Minister Ntsokoane Matekane has recently opened an Artificial Insemination Centre in Quthing, saying it will be fully operational in six months’ time as he has been allocated funds to purchase equipment needed by the farmers.
He said importing hybrid merino and Angola genetics from as far as Australia will no longer be a hassle once the Artificial Insemination centre is complete.
In conclusion, the Minister invited the farmers to be present at the World Food Day commemoration to be held in the Mafeteng district on October 13 this year.
One of Farmers Pitso Awards organisers on behalf of the farmers, Mr. Thabiso Mats’oele said the event has been organised not as a competition to the farmers but as a come together to share views and experiences, saying they were all winners.
He noted that they come together in a form of workshops as well as for study tours in various parts of the country and that they will be undertaking an international trip to Zimbabwe later this year in order to learn what other farmers are doing in order to implement what they learned at home.
The farmers also displayed their products at ‘Manthabiseng Convention Centre that included agricultural products and equipment.
Some of the farmers were dressed in camouflage while others were clad in blankets both male and female.
The Farmers Pitso Award is an annual event held for farmers as one way to motivate them by awarding them with presents for them to increase their produce.

domain: agronomy


Enhancing the Horn Point Cove Trail will help thousands of students and visitors of all ages appreciate the interconnectedness of science, education and restoration for waterfowl populations and natural landscapes.
The National Oceanic and Atmospheric Administration (NOAA) will continue its two-decade commitment to support the next generation of marine scientists and researchers through the Living Marine Resources Cooperative Science Center.
University of Maryland Center for Environmental Science President Peter Goodwin says there is still time to act, but we are operating in a very narrow window. He answers some basic questions about climate change and Maryland.
Researchers at the Institute of Marine and Environmental Technology (IMET) at Baltimore’s Inner Harbor have published the first full reference genome sequence for the blue crab. This means that for the first time we have a complete picture of all of the DNA that makes up Maryland’s favorite crustacean.


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Ideally, term life insurance policies last as long as your principal obligations like a mortgage. But it doesn’t work out that way sometimes. If your term life policy is expiring, you may still need protection if you still have a mortgage, major debts, dependent children, dependent spouse, and trust money to your heirs. If you belong to one or more of these categories, there are several options to consider.
Get another term life policy.
If you still have obligations, the best option is to buy another term life policy. When you’re older, you might have to pay a higher price but buying a shorter term policy may help reduce the cost.
You can also shop around if you want. Even if you’ve got the best deal from your former insurer before, you can inquire at another insurer for a better life insurance rates this time. Bear in mind that you’ll probably have to take a medical exam during the application process.
Opt for annual renewable term life insurance.
Instead of buying a new term life policy for five or more years, you can choose annual renewable term life insurance, where you decide whether you’d want to continue coverage every year. This option may be a good choice for you if you anticipate more years of financial obligations.
You can also ask your agent if you can extend your current term policy one year at a time. Doing so would avoid a new medical exam. This option is also recommended to those with terminal medical conditions who need life insurance.
Convert your term life insurance to a permanent policy.
While term life insurance works for most people, permanent life insurance certainly has advantages. As the name suggests, a permanent policy lasts for the rest of your life. It has three types: whole, universal, and variable.
You may opt to have your term life policy converted to a permanent policy if you need to. You may typically do so without needing a new medical exam. Your agent may give you the option of converting only a part of it.
Get a new permanent life policy.
If you find that you need to buy a permanent life policy, make sure to shop around and get quotes. Don’t hesitate to approach your agents.
Roper Insurance Services is an independent insurance agency that specializes in providing life insurance to the residents of North Carolina. We offer policies that are tailored according to your needs and budget. You may ask for a free quote from us by clicking here. To discuss your options with our agents, you may call us at (828) 697-6709 or visit us at our office today.

domain: finance


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On May 1, Emirates inaugurated daily, nonstop service from Los Angeles and San Francisco to Dubai’s new Terminal 3 at Dubai International Airport.
Emirates is now flying nonstop to Dubai from SFO to LAX.
Daily flights out of LAX and SFO will depart both cities at 4:45 p.m., arriving the following day in Dubai at 7:40 p.m. and 7:20 p.m., respectively.
West Coast passengers will take the long-haul flight aboard one of the line’s Boeing 777-200LR, outfitted with eight first-class, private suites, 42 lie-flat beds in business class and generous space for 216 passengers in economy class. Passengers in all classes will have more than 1,700 hours of video and audio entertainment to keep them occupied during the approximately 16-hour flight.
Emirates is promoting the new service by awarding qualifying passengers with complimentary accommodations at the world’s tallest tower, The Address Downtown Burj Dubai and a coupon booklet with free entry to the Dubai Aquarium & Underwater Zoo and Dubai Ice Rink.

domain: news


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What was Natalie hiding?
That was the big question on Star Season 2 Episode 14 when Maurice brought a new promoter into the fold.
Meanwhile, the competition among the artists continued to heat up, and the label was forced to make big decisions.
Also, Alex and Noah finally got Star's approval, but they realized the relationship was still going to be tested.
Finally, Cassie gave Miss Bruce a job, but was there an ulterior motive at play?
Use the video above to watch Star online right here via TV Fanatic.
Get caught up with all the latest developments now.
Paul Dailly is the Associate Editor for TV Fanatic. Follow him on Twitter.

domain: entertainment


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Bonsai enthusiasts and eco-warriors Shin and Charlene Evangelista of Brookes Point town here in Palawan urged the Free Eco Workshop participants held at Frontier Lodge on July 27, 2019, to plant more trees and try growing plants indoor using water, recycled glass or plastic bottles and variety of trees and plants suitable to be planted.
Ms. Shin stressed the important role of trees in saving and preserving the biodiversity in their town and she gladly announced that their family already planted 100,000 trees as of this date.
Earlier this year, they tried an indoor plant for their lodging house as an added feature to rooms and the receiving area. They were among those interested in growing water bonsai.
They contacted Mr. Edwin Dela Torre, an inventor of Amazing Powder Grower for Water Bonsai, to acquire technical skills and knowledge on how to plant and manage a water bonsai.
Ms. Shin and her sister Charlene, shared and presented to the participants the easy-to-follow procedures and materials’ preparation.
They promote collecting a recycled glass and plastic bottles as containers for water bonsai plant and to help lessen the litters of this waste in their surroundings. The other recycled materials needed are styrofoam and lunch boxes from the fast-food chain.
Apart from the plant and variety of trees suited as bonsai plant, the amazing powder grower served as nutrients of the plant to grow their roots in a couple of weeks plays a vital role in this new hobby of bonsai enthusiasts.
A sachet of powder grower should be mixed in 1.5 liters of tap water, then shaken for 30 seconds, and then wait for the water to become clear prior to pouring into the glass container.
The amazing water bonsai now attracted individuals without a green thumb and ignited their creativity.
“Kelangan lang ng enough light not necessarily direct sunlight for water bonsai, and before maubos yung water sa glass container pwede nyo na palitan ng tap water kaya easy to manage sya kasi di nyo na kelangan magdilig and pwede nyo din sya pagkakitaan at ibenta yung inyong water bonsai plants,” said Shin Evangelista.


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Living in perfect Harmony
A Marilyn Monroe look-alike (Samantha Morton) befriends a Michael Jackson impressionist (Diego Luna) in modern-day Paris and persuades him to join her at an impersonator commune in Scotland, whereupon M.J. kicks it with Abraham Lincoln, Charlie Chaplin, Buckwheat and Madonna.
It’s a Harmony Korine film, right?
Yup. And the outsider artist’s latest, Mister Lonely, is, all things considered, a surprisingly conventional tale of unconventionally ruined lives. There are three acts, a main character and what appear to be scripted scenes and dialogue—a major departure for Korine. Only a couple transitory Greek chorus-like vignettes at the conclusion of each act—featuring German filmmaker and Korine pal Werner Herzog as a Catholic missionary—hint at the loose, improvised style of his previous films, Gummo (with its famous kitchen-chair scene) and Julien Donkey-Boy (the memorable rap: “I’m a black albino straight from Alabama …”).
Korine’s maturing as a filmmaker, and the results are favorable. Fans of post-New Wave filmmaking will long for happy accidents, like slow-motion shots of Chloë Sevigny’s bouncy electric-tape-covered nipples in Gummo. But the stuffy European in all of us will admire Korine’s loving attentiveness to each frame: beautifully composed shots (M.J. dancing on a rock in a Scottish bay) and boldly choreographed sequences (skydiving nuns!). Filmgoers that take chances will find Korine’s empathetic storytelling engaging, if at times unobvious and belabored.
The Joe the Plumber crowd, however, will be confused as all hell, which is problematic: Mister Lonely, of all things, is a “Blockbuster Exclusive” DVD, meaning you can only rent it at the hated retailer. Most Korine fans avoid Blockbuster like you could acquire herpes B from membership; Blockbuster renters will fume when Mamma Mia! is sold out and suddenly have to settle on “the cute DVD with Marilyn and M.J. on the cover.”
Oh well. It’s good for them, like steamed bok choy.

domain: artistic


EXCLUSIVE: Feds, defense in legal duel over whether undocumented immigrant has a Second Amendment right An undocumented immigrant fires a gun on a Brooklyn sidewalk to frighten off gang rivals. He gets arrested on a federal charge of being in the U.S. illegally and possessing a gun. But he claims he has a Second Amendment […]
The post Illegal Rights, a Final Las Vegas Report and NRA #FakeNews – TTAG Daily Digest appeared first on The Truth About Guns.
Source:: Truth About Guns


Britain’s Men’s 4x100m Medley Relay team brought a historic Tokyo 2020 pool swimming programme to a dramatic close by securing a brilliant silver and ensuring Team GB’s best-ever swimming medal haul at an Olympic Games.
The quartet of Luke Greenbank, Adam Peaty, James Guy and Duncan Scott teamed up to smash their own European record in 3:27.51 with four brilliant legs of relay swimming, only to be touched out by the USA team’s world-record breaking effort.
The silver – which also goes to James Wilby for his important heats contribution – is Team GB’s eighth medal from the pool after an unforgettable nine days of competition, surpassing the seven-strong haul from the 1908 Games in London.
Among the other landmark achievements to follow a heart-stopping race was Scott’s confirmation as the first ever British athlete in any sport to claim four medals at a single Olympic Games, while Peaty and Guy both picked up their third of the meet.
This race always looked set to be one of the tightest of the entire week, and Greenbank – fresh from an individual 200m Backstroke bronze on Friday – ensured Britain’s shot at the title got off to a solid start, splitting faster than he did in the 2019 World Championship victory swim.
Triple Olympic champion Peaty took over from his Loughborough National Centre teammate, diving in seventh and quickly hauling in every one of the rivals ahead on the way to the fastest 100m breaststroke split of all time, a 56.53 handing the lead over to Guy on the butterfly leg.
Bath National Centre man Guy produced one of the swims of his life in helping Team GB to Mixed 4x100m Medley Relay triumph 24 hours earlier, and he left everything out in the pool once again as he battled with individual 100m Butterfly world-record holder Caeleb Dressel, in an outside lane.
Last up on the freestyle was Scott, on the verge of both individual and team history in the pool and duly delivering again in the final two laps of a relentless meet for the University of Stirling competitor.
While just unable to overhaul the Americans’ lead on the anchor section, Scott – who works under Steven Tigg in Stirling – served the latest reminder of his world-class racing abilities to push the eventual winners right to the wall and ensuring Britain went well under their own European record.
Reflecting on a breathtaking race, Peaty said: “I lay it all down there, I knew I had to go an extremely fast time and that was an extremely fast time. Unfortunately we didn’t do enough to take that gold, but with the success British Swimming have had and we have had, sometimes you need a little bit of pain.
“This is painful, and I know people at home will say we got Olympic silver, but that’s the standard we are at now, we’re not looking at bronze or silver, we’re looking at how to get gold. That’s just my mindset, and I know these guys are disappointed as well, that’s just the honest opinion of our performance and what we thought we could do. But that’s a world record for them, you can’t ask for more, and it’s my fifth medal at two Olympics."
Guy added: "The way this week has been for British Swimming is unbelievable, with medals all over the place. If you’d talked to us in 2015 or 2016, we’d have bit their hand off. It’s been a great meet so far, we’re a bit sad that we didn’t get the gold today but it’s a world record and we played our part in that."
On becoming the most decorated British athlete at one Olympic Games, Scott said: "It’s all my teammates, that’s what that is. I’m fortunate to be part of some excellent relay teams, this being one of them. We’re all pretty disappointed with this, but in 2015, when we started coming together, back-to-back Olympic silvers in this event, we’d have taken that all day.
“We're coming in here to really challenge the Americans just like we did last time at Worlds. With our splits, we all swam well, slightly disappointed with mine but that’s how it is. It’s been a tough week, but we’ve got to be happy with that.”
After receiving a second medal in his debut Games, Greenbank said: "Obviously the 100m Backstroke isn't my main event, but I came in here, really worked at it in training because I know I’ve got these three lads here who are all world-class in their event. Like Adam said, it's frustrating to be second, but with all the medals we’ve had this week, there have been some incredible results. We can build on this and come back stronger."
With the pool swimming done for Tokyo 2020 and British history made as the greatest Team GB swimming performance of all-time, how does Peaty feel as he looks to the future now?
"We wait for a new generation to come through. You look at most of the team now, not just in swimming, in all sports, there's a new generation of athletes coming through, one that’s a lot more aware of self, which is really important," he added.
"We’ll use this to reflect, it’s very important to reflect, how do we get better? We’re not quite sure yet, but before we go hard again, we’re going to take a big break because sport is hard, it's 24/7, 365. We’ve come a long way."
[Credit: Stream every unmissable
moment of Olympic Games Tokyo 2020 live on discovery+,
The Streaming Home of the Olympics.]
Earlier in the session, Ben Proud narrowly missed out on the podium in the Men’s 50m Freestyle as he registered a top-five finish in the Olympic event for the second successive Games.
Proud earned himself a lane in the ‘splash and dash’ finale after a solid semi-final on Saturday, having waited through the first six days of competition to open his Tokyo 2020 campaign the previous day.
The 26-year-old former world champion had the quickest reactions off the blocks in the final, putting himself into contention for a medal across a blanket field, barring the lead of the USA’s Caeleb Dressel.
The stroke rate remained high, but Proud – who is training in Mark Skimming’s University of Bath squad – was touched out of the medals by less than two tenths of a second in a nip-and-tuck finish.
“It’s a tough one, that’s for sure. A lot of people have invested their time and energy into me, I wish I could’ve brought them something home but that’s just how it is,” he said.
“Swimming has taken me on an amazing journey. To be at the Olympics, it’s been a tough year, a tough couple of years and I’m still motivated to come back and keep swimming. My family, my girlfriend, everyone has been massively supportive.
“The good thing is some of the athletes in there are getting well into their 30s and are still going, so I’ve got a couple more years left. I thought this one was a good one for me, it just didn’t quite happen but that’s how it is.”
There was also a fifth-place Men’s 1500m Freestyle finish for Daniel Jervis in his maiden Olympic final appearance.
The Swansea Aquatics man, who trains under coach Adam Baker, was pleased with a semi-final swim that saw him fifth-fastest into the final – and Jervis remained in touch with the leading medal contenders over the opening 500m.
As the top four began to move clear over the second 500m, Jervis had to remain disciplined in his own race, sticking well to his stroke rate and technique to ensure he held off the rivals behind him and registered a solid result on the biggest occasion of his career to date.


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domain: economics


The limited edition Falcon Sprint was revealed publicly at the 2016 All-Ford Day in Geelong.
Three pre-production models were displayed at the show, along with newly revealed information. Both cars feature a heavily revised powertrain calibration and suspension set-up as well as launch control on all variants as standard. New high-performance Pirelli tyres and Brembo brakes have also been added.
The XR6 Sprint is not only the fastest six-cylinder Falcon of all time, but might even be quicker than its eight-cylinder sibling. Making 325kW of power and 576Nm of torque the new car has a 55kW and 43Nm jump on the standard XR6 Turbo. However, when the six-pot Sprint finds overboost mode, power leaps up to 370kW and 650Nm of torque.
The car is able to make these figures thanks to a revisited engine and gearbox calibration to suit it’s larger turbocharger, bigger injectors and intercooler. Also aiding in the increased power output by optimising air-flow, is a specially designed carbon-fibre air intake system.
“The Falcon’s legacy will live on well beyond this year through our designers and engineers that will continue to innovate to make Australian’s lives better,” says Graeme Whickman, president and CEO, Ford of Australia. “The Falcon XR6 Sprint’s new innovative carbon fibre engine air intake is the latest example of how our local engineers and suppliers will reshape the auto industry well into the future.”
The V8 powered XR8 Sprint produces 345kW of power and 575Nm of torque – that’s a 10kW and 5Nm jump on standard. In overboost mode, the XR8 Sprint makes a very impressive 400kW of power and 650Nm of torque.
All variants are equipped with specially designed Pirelli P-Zero tyres. The new tyre set-up is said to improve handling and reduce braking distances. The tyres measure 245/35 R19 at the front and 265/35 R19 at the rear. Handling dynamics are further improved with 335mm big-slotted and cross-drilled Brembo brake discs with six-piston callipers at the front, and similiar 330mm discs with four-piston callipers.
“All Fords are renowned for their dynamic DNA – from steering to ride and handling – and with the XR Sprint series our enthusiast customers will experience a number of improvements first-hand. The ride and steering response has improved and the cars feel more agile and can easily be adjusted mid-corner.” Said David Wilkinson, Vehicle Line Director of Falcon and Territory.
The Ford Falcon Sprint will be put into production in April when orders close, with only 500 XR6s and 650 XR8s to be made for Australia. Pricing starts at $54,990 and $59,990 respectively.


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domain: geography


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To start, becoming a chef is not generally as simple as someone would possibly consider by reading the web bio of Mario Batali or Michael Symon. The long street to the highest could be extraordinarily challenging. Many start in culinary college in packages that range from one to 4 years. One misconception is that after you graduate from considered one of these applications you’re a chef. What it really does is open extra employment options and lets you hit the bottom running in knowledgeable kitchen. Culinary college teaches a scholar the basics of French cuisine. To develop into a chef would require a number of extra years of practical expertise in plenty of professional kitchens.
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2. Medicinal herbs – Do you know that ten p.c of over-the-counter medicine are man-made medicinal vegetation, and close to 80 % come from vegetation? Herbs are actually recognized as the most effective different to medicines. These herbs embody garlic, gingko, hypericum, valerian and Echinacea. Many individuals additionally get pleasure from aromatherapy to alleviate stress, and profit a lot from mint, roses, lavender and basil.
All vegetables are inspected for bugs or insects. All dairy foods are saved separate from the meat of an animal. This necessitates the usage of two kitchens and separate plates. All fish should have fins to be thought of clean and kosher. No unclean animals or sea food is used. These are but a number of of the kosher food tips.
Parsley is a good herb to make use of in fish dishes.
The duties of a commis chef could be just about anything that his or her head chef requires. They might be making ready vegetables and food for the day. A commis chef ought to know they’re on the lowest point of the rank and may have the ability to put up with anything. Often it’s not an excellent surroundings to work in with orders from other chefs shouting at you, demanding you to run across the kitchen and do their soiled work, but that is the place everybody began and you can’t shoot straight to the top.
Now, with this article you be taught that you’ll want to choose the appropriate kits when beginning an herb backyard within the backyard, in your windowsill or even in pots and containers. Selecting the best package is necessary as it’s going to information you thru learn how to develop your herbs efficiently based mostly on the form of herbs that you just wish to develop.
Batali is most well known for his Italian food, however he has mastered a number of cuisines which he uses to his advantage on Iron Chef America. Cooking gentle is healthy cooking. When on the lookout for taste enhancers which are a step away from a conventional recipe, attempt utilizing lemon grass, Vietnamese mint or basil.

domain: food


Hell Bunny Solaris Blouse
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It's written in the stars; your next purchase is this bewitching blouse from Hell Bunny! Scattered crescent moons and glittering suns decorate the floaty, chiffon material of this beautiful design, taking your alternative look to new and starry heights.
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Cherie Blair turns football fixer to boost son's career as an agent
- Car picks up Mexican prodigy from his trailer park to meet ex-PM's wife
- She holds meeting with him at Los Angeles hotel
- Then sends his mother signed autograph of her and Tony
Cherie Blair has taken time out of her busy international schedule to meet an unknown Mexican footballer to help boost her son’s sports agency business.
A car collected 17-year-old soccer prodigy Raul Mendiola from his family’s rundown trailer-park home in a Spanish-speaking suburb of Los Angeles and took him to the plush hotel where the wife of the ex-Prime Minister was staying.
Mrs Blair – who is a director of her son Nicky’s football agency, to which Raul is signed – spent time chatting to the footballer before posing for a photograph with the bemused youngster.
Rising star: Cherie Blair met up with Raul Mendiola in Los Angeles
Just days later, in an apparent attempt to cement confidence in her son’s business, Raul’s mother Claudia Velador received a picture of a smartly dressed Mr and Mrs Blair, personally signed with the words ‘Thank you’.
Claudia said the picture has now been framed and takes pride of place in the living room of the family home.
Raul, who moved to America from Mexico ten years ago following the break-up of his parents’ marriage, hopes to become a football star after signing to Nicky Blair’s Magnitude Limited sports agency.
Friends in high places: Sports agent Nicky Blair got a boost from his mother
But he had no idea he had entrusted his future to a man whose parents are on first-name terms with the world’s most powerful people.
Speaking from her home in San Bernardino, California, Claudia, 36, said: ‘Raul didn’t have a clue he was dealing with a former Prime Minister’s son.
‘A car came to pick him up at our home and take him to Los Angeles, which is about an hour away. He was taken up to her hotel room and had pictures taken with her, but it was only on the way out when he asked why there were so many photographers in the lobby downstairs that he was told they were there for the mum of his agent because she was a famous person.
‘A few days later she sent me a signed picture of her and Tony Blair. He is in a suit in the picture and she is dressed very smartly.
Signed photo: Raul's mother received a signed photograph of Cherie and Tony
‘It says “To Claudia” with some scribbles underneath, which I assume are signatures, and then the words “Thank you” in English.
‘I’ve framed it and hung it up in the living room. I’m Mexican and although I’ve seen Tony Blair on the television, I haven’t attached all that much importance to it.
‘But friends are like, “Wow, this is amazing, these are really influential people” when they see the signed photo and I tell them the story behind it.’
Mrs Blair, a Liverpool FC fan, had been in Los Angeles to give a speech to lawyers on September 15. She became a director of the sports firm in 2009 after Nicky set up the company with Oxford University friend Gabriel Moraes, 25.
Nicky, 26, and Gabriel have made several trips to the United States in recent months as they look to add to their stable of budding footballers to represent.
After signing Raul earlier this year they arranged a trial for him at Manchester City, the world’s richest football club.
Claudia said the two budding agents even collected Raul from the airport and put him up at their shared home in Marylebone, Central London, before driving him to Manchester for the trial.
That led Raul’s stepfather Pablo Andujo to boast on Facebook that the player was ‘spending his first week at the Blair mansion in England training with his trainer’.
If the Mexican-born prodigy, who is nicknamed ‘guero’ or blondie in Mexican slang because of his pale skin and blue eyes, is signed to the Premier League football club or another top European side, he can expect a life far different from the one he has been used to.
He was born in the notorious Mexican border town of Juarez, known as ‘The Murder Capital’ where his father and other siblings Michelle, 18, and Jonathan, 15, still live.
Claudia added: ‘It’s nice to know Raul is in such safe hands. His dream is to become a professional footballer and play for a side in Europe. I’m sure my son will achieve his dream and become a good player.
‘It’s something he wants desperately and if someone as important as Cherie is taking an interest in his future, then I’m delighted.’
A spokesman for Manchester City confirmed Raul had been on trial with the club.
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Book Name: Waqt Jo Thehar Gaya Novel
Writer: Qaisra Hayat
The book Waqt Jo Thehar Gaya Pdf is an excellent social and romantic novel by Qaisra Hayat. In this story, the writer described many issues for the public but mainly focused on love. Qaisra Hayat explained the pains and difficulties faced by couples in our society. This story was dramatized for a leading television channel with the title of Tu Jo Chahay and gained a large viewership.
Qaisra Hayat is a leading female Urdu novelist, story writer, and drama writer. In his brilliant writing career, she authored dozens of books and novels. Qaisra Hayat is writing some serialized stories for digests and magazines. I hope you like to read the book Waqt Jo Thehar Gaya Pdf and share it with your contacts.

domain: library


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Dr. Woodrow's Background
Sarah I. Woodrow, MD is a practicing Neurosurgeon in Kansas City, KS. Dr. Woodrow accepts multiple insurance plans including Aetna, Humana and Cigna. Dr. Woodrow also practices at Kansas University Physicians Inc in Kansas City, MO. In addition to English, Dr. Woodrow's practice supports these languages: Vietnamese, German, Russian, Spanish, French and Arabic.

domain: health


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Using interview triads to understand the barriers to effective food security policy in Kenya: a case study application
- 407 Downloads
This paper presents the results of an exploratory study on food security policy in Kenya. Key informant interviews are used to provide a ‘multiperspective’ lens through which to garner insights into Kenya’s food security policy processes and emerging resilient farming system practices. Seeking to situate the policy-making process in its ‘real-life’ institutional context, we identified three interlinked institutions (at government, research and farm levels) and interviewed individuals within each who could speak authoritatively on food policy challenges. We concentrated on Wote, a semi-arid agro-pastoral area in Makueni County, Eastern Province. From different starting points, the interviewees came to agree on the biggest challenges to the development of effective food security policy in Kenya: information, research and education. The paper further reflects on the methodology and assesses its potential efficacy in the study of hunger and its solutions, especially in the realm of knowledge integration, the democratization of research and policy-making processes and the opening up of reciprocal communication pathways amongst institutional actors.
KeywordsFood policy Methodology Information Oral history Governance
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- Kristjanson, P., Reid, R. S., Dickson, N., Clark, W. C., Romney, D., Puskur, R., MacMillan, S., & Grace, D. (2009). Linking international agricultural research knowledge with action for sustainable development. Proceedings of the National Academy of Sciences, 106(13), 5047–5052.CrossRefGoogle Scholar
- Kwayera, J. (2011). Intricate graft networks fuel food insecurity. Standard (Nairobi), 29 July. http://www.standardmedia.co.ke/InsidePage.php?id=2000039865&cid=4&. Accessed 29 July 2011.
- Loorbach, D. (2007). Transition management. New mode of governance for sustainable development. Utrecht: International Books.Google Scholar
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domain: literature


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Book Review: Melichson, Art of Paper Cutting
Posted by Avital Pinnick on November 9, 2009
Henya Melichson, The Art of Paper Cutting (Quarry Books, 2009)
Henya Melichson brings years of art experience to her book on paper-cutting, recently published by Quarry Books. Her background in painting and drawing is evident in her detailed, almost three-dimensional, quality of her paper cuttings. In fact, she likens paper cutting to drawing with a knife.
Born in Tel Aviv in 1953, Melichson worked in oils, aquarelles, and sketching until 1984, when she turned almost exclusively to paper cutting. She is a member of the Guild of American Paper Cutters.
Her book begins with general instructions for paper cutting. The body of the book is an extensive selection of paper cuttings that she has made over the years. They are stunning. Her style ranges from classical to folkloric to art deco, with many cuttings devoted to Jewish themes. These photos provide a sense of her intricate and versatile style. (Note: if you want to see higher resolution versions, click the photos to go to the Flickr page. Click “All sizes” to see a larger size.)
I think my favourite is this paper cutting of a woman in a window overlooking a garden (below). The alternating positive and negative borders around the window are striking and unusual. The woman’s face is rendered in a 3/4 pose, much more common in painting and drawing than in paper cutting.
Jerusalem is a perennial favourite among Jewish paper cutters. Here, the feathers of the doves surrounding the city of Jerusalem are in the spiky style of Polish paper cutting. Melichson’s more elaborate cuttings are often accompanied by details with notes.
In the lower right corner, she shows layers of bricks cut in positive. If you look at the buildings on the left page, you can see bricks in the negative. The juxtaposition of positive and negative creates different values of shadow, a subtle means of conveying depth in a flat medium.
The heart with animals (below) is a common paper-cutting motif in Europe, especially Switzerland. The tip on the facing page is to draw the “hidden” animals before the foliage.
If you want to see an extraordinary use of positive/negative, see how the vines cross the cherubs’ bodies at the bottom of the composition. It’s almost subliminal.
Now look at the top of the trunk of the heart-shaped tree. The positive and negative elements are so evenly balanced so that you can’t tell where the trunk ends and foliage begins.
The book concludes with a section of templates for simpler projects.
In all fairness, I should point that this book will not teach you to make paper cuttings like hers. The templates are, however, suitable for a beginner. If you have never attempted paper cutting before, this is something to bear in mind before you rush out and buy the book. If you already have paper-cutting experience or are an ambitious beginner, keep reading.
Most of the patterns in the main part of the book could well have the following directions:
1. Fold paper in half.
2. Draw insanely intricate drawing.
In all fairness, most of her paper cuttings are too large to allow the inclusion of templates in a small format book. She would have to put them on a CD. Besides, the goal of a good how-to book is to inspire you to branch out in your own directions, not to copy the work of the master. Her patterns are not patterns in the conventional sense. The value of her book lies in where it takes you after you’ve mastered the basics.
The Art of Paper Cutting fills an important gap in the available books on the subject, most of which teach the craft at an extremely basic level. Stewart Walton’s Craft Workshop: Paper Cutting is a representative example. Walton provides templates for a range of projects that are generally not too difficult. After you have mastered greeting cards, shelf edgings, and a few bookmarks, what’s next? There are almost no books for the intermediate level of this craft.
If you have some paper-cutting experience under your belt already, study Melichson’s treatment of hair, facial features, architectural details, and perspective. Her background in painting and drawing distinguishes her paper cuttings from most other artists’ work.
This book reinforces a notion I have long suspected: If you want to take your paper-cutting skills to the next level, you have to develop your sketching and drafting skills. Cutting paper is not a difficult skill to master, provided you have adequate coordination, eyesight, and a supply of fresh blades. The real test of skill lies in designing a balanced and effective composition. Melichson’s short section on negative and positive design in paper cutting is one of the few discussions of the problem of portraying three-dimensions in this most uncompromisingly two-dimensional of crafts. She succeeds in creating a world of perspective, light, and texture, with tiny holes in paper.
I will leave you with one tip: tracing templates is tedious and inaccurate. It’s much easier to photocopy or scan and print the template on white paper and staple it (through areas that will be cut out, obviously) to your cutting paper. The stapled areas must be cut last to ensure that the layers do not slip.


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Loving art knows no bounds. Plenty of people would love to dedicate their lives to something aiding the arts, but might lack in artistic ability or simply feel it’s best left to the pros. There are many ways to be involved in the arts, further the field, and even get paid for it. Here are some careers in the arts for non-artistic art lovers.
Film festival organizer
If movies are your passion but you just don’t see yourself working in film production, you can use your skillsets to be heavily involved in the film industry without making films. If you’re well-organized and good at prioritizing and multitasking, film festival organization might be a great career path for you. You would select a location, come up with submission requirements, acquire judges, recruit filmmakers, market to the public, and run the event—think snacks, drinks, evening flow, etc.
By becoming an art teacher, you can share your love of art with the next generation of artists. Many famous artists later thank their art teachers for inspiring and encouraging them at a young age to pursue and perfect their craft. While teaching is often a grueling profession, it’s still a very rewarding one. You’ll get to influence the future while educating children about works of past great artists.
Art or movement therapist
Combine your love for art and your love for helping others by seeking a career in art or dance movement therapy. These non-traditional therapy forms are up and coming fields—meaning you’d get to help pioneer a new and very exciting industry. Art therapy uses expression through art to help with emotional responses and promote positive mental health. Dance movement therapy utilizes movement of the body to encourage mental and emotional healing and expression. Both of these careers require proper licensing, so be sure to find a good mentor and educational program before setting out to open your own practice.
An art curator has many responsibilities, including picking out the perfect pieces for an exhibit, gallery, or even a client’s personal collection. They ensure the right art is selected, safely shipped, and displayed properly. This career requires an extensive knowledge of art as well as expert organizational skills. This is a perfect career for those who love learning about art styles and have a good eye for up and coming artists.

domain: hobby


Gushers & Dusters: A weekly look at what we liked -- and didn't
Dec. 8, 2017 at 12:04 a.m.
GUSHER: For the six-county coalition working together to bring our area's Small Business Development Center to the UT Tyler Longview University Center. The center, which had long been based in Kilgore, was moved to Tyler in the past year. That was a bit far afield for some of the counties it serves. The move is another reminder of what can be accomplished with cooperation and communication.
DUSTER: For the Texas Department of Agriculture for allowing a computer security breach that could have compromised area students' personal information. The department oversees school breakfast and lunch programs, which is why the districts were affected. At least eight in the Longview area were scrambling to protect their students.
GUSHER: For the abundance of opportunities across East Texas to get into the Christmas spirit. As this is being written, downtown is gearing up for the Longview Ambucs Christmas Parade, which drew more than 100 entries. Other parades have been and will keep rolling in cities across the region, and this past weekend saw other events to delight young and old in downtown Longview, at Kilgore College and elsewhere. There is no reason not to get out and enjoy this most joyous season.
GUSHER: For the Pine Tree High School cheerleading team, which earned a bid to the Universal Cheerleaders Association's national championship this year. That is quite an accomplishment for a program that has been working at it only a couple of years. It is so new, in fact, that the squad lacks the budget to make the trip to the championships in Florida. For now, they're focused on UIL competitions in January. We bet they can make the nationals trip next year.
DUSTER: For a politically inspired rush to judgment after an incident near Van Horn that left one Border Patrol agent dead and another injured. Gov. Greg Abbott, Sen. Ted Cruz and President Donald Trump jumped on the incident, which they called an attack, to argue for throwing more money at border security — despite the fact border arrests have dropped precipitously. They have been strangely silent since a local sheriff said the tragedy appeared to be caused by a traffic accident.
GUSHER: For the effort already beginning to make sure Longview has one heck of a birthday bash in 2020 when it will turn 150 years old. Our city's rich history is worth remembering and celebrating in such an event, and we are grateful to Longview Community Services Director Laura Hill and others who are leading the effort to make sure 2020 goes down in history, as well.
GUSHER: For the five Longview and area football teams that made it to the state quarterfinals round in state playoffs. The list includes Longview High School, which will take on rival Lufkin on Saturday at SFA's Homer Bryce Stadium. Still taking the field this weekend as well are Carthage, Henderson, New Diana and Tenaha. We are proud of all the programs and wish every one of them the best of luck.
— Readers are invited to nominate events as gushers or dusters. They may be emailed to email@example.com or mailed to Letters, P.O. Box 1792, Longview, TX 75606.


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So, it happened. You walked away for too long, or turned the heat up too high, and suddenly you’re left with a separated (or broken) sauce. Don’t fret! Blue Apron chef Emily Ziemski is here with some key steps you can take before, during, and after making your sauce to make sure that it will be a smashing success.
What is a broken sauce?
“Breaking” can only happen when you’re making an emulsified sauce, like a hollandaise or a beurre blanc. Instead of a velvety emulsion, where the droplets of fat are suspended in liquid, a broken sauce has separated back out into liquid and fat. A sauce on the brink of separating will show little fat droplets forming around the edges. A fully broken sauce will look distinctly separated (like it’s two different sauces), very liquidy (or loose), or grainy.
How can I fix a broken sauce?
- Add a little liquid––if you’re just beginning to notice signs of breaking––droplets of fat forming around the edges of the pot or pan––don’t add any more fat, but revert back to adding just a teaspoon or two of your ‘base’ liquid (water, broth, vinegar, etc), and keep judiciously stirring or whisking until the sauce tightens up again.
- Work over consistent heat––sometimes a big jump in temperature can cause the emulsion to break and separate. While cooking, keeping the heat low and slow can keep your sauce happy and together!
- Add a little fat back––a classic emulsified sauce is typically a 1:1 ratio of fat to liquid! If your sauce is breaking but is also very thin, vigorously whisking in a little fat (butter, egg yolk) can bring it around.
- Whisk whisk whisk––sometimes all a sauce needs is a little zhuzhing to come back together. If the sauce starts breaking while you’re making it, don’t add any more ingredients, just turn down the heat and give it a good whisking until the ingredients re-emulsify.
- Warm it up––if a finished sauce sits for too long, it loses heat and stability, which can threaten the structure of the sauce! Reheating it slowly while consistently stirring or whisking can whip your sauce back into main dish shape.
- Start from scratch––don’t throw out your broken sauce, but start your base anew, then slowly combine the two sauces over heat. Voila! Now you have a little extra sauce.
How can I prevent this from happening to my future sauces?
- Add a thickener while you’re making it–– adding cornstarch or flour to the liquid before adding (be sure to get out any clumps) can add some stability to your sauce.
- Temper your ingredients–– to avoid shocking the sauce (adding a cold ingredient to a hot sauce), you can take some of your sauce and spoon it into whatever ingredient you’re adding next. Whisk to combine, and then slowly pour in the tempered mixture! Shock avoided!
- Reduce your acids–– if your sauce is acid-based and also has a dairy component (eg: beurre blanc), make sure that the acidic liquid (wine, vinegar) is fully reduced in the pan before adding any dairy!
- Never bring a dairy-based sauce to a boil; this can cause them to curdle.
Blue Apron makes learning new cooking techniques easy. Sign up for ingredients and step-by-step instructions delivered to your door.


text:
The use of simulation to develop clinical reasoning and medical decision-making skills for common events is poorly established. Validated head trauma rules help identify children at low risk for clinically important traumatic brain injury and guide the need for neuroimaging. We predicted that interns trained using a high-fidelity, immersive simulation would understand and apply these rules better than those trained using a case-based discussion. Our primary outcomes were to determine the effectiveness of a single targeted intervention on an intern's ability to learn and apply the rules.
This was a prospective randomized controlled trial. Interns were randomized to participate in either a manikin-based simulation or a case discussion. Knowledge and application of the Pediatric Emergency Care Applied Research Network Head Trauma tool were assessed both under testing conditions using standardized vignettes and in clinical encounters. In both settings, interns completed a validated assessment tool to test their knowledge and application of the Pediatric Emergency Care Applied Research Network Head Trauma tool when assessing patients with head injury.
Under testing conditions, both being in the simulation group and shorter time from training were independently associated with higher score under testing conditions using standardized vignettes (P = 0.038 and P < 0.001), but not with clinical encounters.
Interns exposed to manikin-based simulation training demonstrated performance competencies that are better than those in the case discussion group under testing conditions using standardized vignettes, but not in real clinical encounters. This study suggests that information delivery and comprehension may be improved through a single targeted simulation-based education.

domain: medical


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