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Already an icon in the eyes of many a motoring journalist, as well as owners alike, the 1M Coupe turned the BMW 1 Series into something rather special.
Pistonheads even ran an article in 2014 declaring it one of their hero's - quite an accolade for a car that was only 3 years old, declaring it "A cast iron investment that's an utter riot to drive - what could be more heroic than the 1 M Coupe?"
A high-performance version of the 1 Series Coupe, it was , developed by BMW's motorsport branch BMW M. While BMW naming convention would have called the car the "M1", the name "BMW 1 Series M" was used instead, to avoid confusion with the original BMW M1.
The 1M Coupé used a re-tuned version of the twin-turbocharged N54 engine which is used in various other models, In the 1M Coupe, the engine produces 340 PS (250 kW) at 5900 rpm and 332 lb·ft (450 N·m) torque from 1,500 to 4,500 rpm (with +369 lb·ft (500 N·m) overboost). The only available drivetrain is a six-speed manual gearbox with a limited slip differential.
The 1M Coupé has a significantly wider track and bigger body than the standard E82 coupé, as well as a different body kit. Despite the car's larger size, it is 77 lb (35 kg) lighter than the standard E82 coupé, giving it a weight of 3,296 lb (1,495 kg).
Demand was strong, but production was limited to 450 Units for the UK market, so are likely to be a car with demand that always outstrips the now only dwindling supply.


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Marina Lazaris - CPCC ACC
Every professional displayed on Life Coach Directory has been independently verified by our team to ensure they have suitable credentials to practise.
This professional is available for new clients.
This professional is available for new clients.
Author - Men Need Love too- By Marina Lazaris available on amazon.
1:1 coaching for individuals and workplaces currently navigating a period of change, looking to find peace amongst the chaos and come out of that transition triumphant.
I’m only the right coach for you if:
- You’re prepared to be fully present (no half-in, half-out types)!
- You value your time and don’t have months to spend being ‘emotionally unravelled’
- You’re committed to taking back control over your life/business
- You don’t want to miss out on accessing the dormant power that already lies within you/your team.
- You’re seeking a safe, straight-talking space with someone who won’t try to ‘fix’ you.
- You’re ready to be held accountable in your growth with regular follow-ups.
Whether you’re ready to transform your turmoil into triumph, or simply want to connect:
1. Send a note with your invitation & include the word “RESET”
2. Tell me something about yourself that most people wouldn’t guess!
Individual Coaching Surgeries:
Full/half-day retreats to access true peace & power amongst the chaos of life’s transitions. An immersive experience to ignite your full emotional range and realign you with your core values.
Thanks to a proprietary method that integrates subconscious reset, systematic coaching, acting and psychology, there is no need for months of ‘unpacking’.
We work together to put you back in the driver’s seat of your life, armed with an understanding of how to tackle your transition in a way that brings you maximum fulfilment and a newfound sense of freedom.
Coaching covers many areas, including but not limited to:
- Health and well-being
- Relationship transitions
- Career transitions
Are you investing in creating a healthy, harmonious working environment? What are you doing to move your business from stressed and overwhelmed to fired up and inspired?
Working 1:1 to boost growth and fulfilment in your workplace with confidential drop-in surgeries. That means a boost in morale, retention and profit for your organisation, thanks to:
- More effective, emotionally intelligent leadership
- Increased productivity & job satisfaction
- Harmonious workplace culture with increased collaboration
Coaching for your team on everything from retaining top talent to nurturing relationships with colleagues and clients alike. Areas include, but are not limited to:
- Sales & negotiation strategy
- Relationship transitions
- Work-life balance
- Health & wellbeing
- Exploring new business perspectives when growing your company
- A sounding board that’s outside your professional network
Training, qualifications & experience
- CTI Co-Active Coach ( The longest coaching training available over 3 years training.)
- Certified Co-Active Coach CPCC
- Relationships Coach/ Dating Mentoring
- Advanced laws of attraction practitioner
- Counselling AQA aim awards
- Sales trainer
- Career Coaching ( Firework Coaching)
- Mentoring available
- Business coaching
- Personal development
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Coaches can become accredited by the ICF, who have three grades of membership: Associate Certified Coach (ACC), Professional Certified Coach (PCC) and Master Certified Coach (MCC), with the different categories standing for different levels of training and experience. Master Certified Coach's have achieved a substantial level of training and experience.
Members of ICF are accountable to a professional code of ethics.
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Well what can I say....Absolute genius of a life coach, picked me up when i was literally in the gutter and transformed my life in the matter of weeks, I couldn't make decisions and didn't know my left from my right! no exaggerations, Now through her guidance im flying high... The world better watch out because im coming for you. BACK ON TOP living in imperial Wharf trading is on another level and in the music business, so watch this space next year.
—Daniel Simons, Forex Trader
Marina was instrumental in helping me to move forward. After relocating all the way across America - yes, from Florida to California - I found myself struggling to get settled in my new location. I'd closed my business in one state and was faced with the prospect of re-building from scratch with no sense of my place in the community, very few friends and a ticking bank account. I had internalized all of this stress. It was non-productive and detrimental. On a conscious level, I knew I had done it, but I was having difficulty letting it go. During my Skype discussion with Marina, she guided me through a series of exercises that helped me to both express and release my negative feelings (anger, fear, frustration, etc) and build a new perspective based on my goals and accomplishments. I have not looked back. Forward movement was immediate. I highly recommend Marina if you are finding yourself mired in a similar place of stagnation. After a session, you will find yourself in a new mindset focused on success and possibility.
—Daniel Olexa, CCHT
“Marina is great, very helpful and is a great driving force in my business and my life!" — Farid Haddad, Director BMA Models
“Marina has played a pivotal role in helping me find the balance, awareness, focus and so much more in both my business and life. Marina has added huge value and I can not recommend her enough. One word comes to mind AMAZING "
— Fan Costi, Luxury Lifestyle Consultant
"Gold Coaching London has proven to be excellent, I thoroughly recommend their services. This was my first time working with a Leadership coach and the results have been tremendous, after just a few sessions. " — Georgina Levy, Business development director, Tiki Style Middle East
"Marina Androu is one of the most positive people I know. As a Co-Active coach she brings her unique talents and energy to empower the coaching relationship in a very special way. Dedicated, focussed, energetic and vibrant I would recommend Marina!"
— Gary Parkin, Director, Partnered Thinking Limited
"Marina brings a freshness and liveliness to her coaching that puts clients at ease. Marina's style is empathetic and supportive, while being challenging in a manner that empowers her client to see things from a bigger perspective."
— Charles Spiropoulos, Policy & Communications
"Marina Androu is an amazing coach. Very intuitive and delivering results. I would highly recommend, corporate coaching, executive coaching and leadership coaching!"
— Susanne Schwameis, Entrepreneur
"Marina Androu has so much energy and is an inspirational person. She has an amazing authentic intuition and remains focused on anything that is necessary to achieve the best results for her clients. I would not hesitate in recommending her as a coach - I look forward to working together again very soon."
— Stephen Ellis, Marketing Guru
At work, your work colleague rubs you the wrong way. Tricky stakeholders feel impossible to manage. Team members who are hell-bent on ruining your day.
At home, your partner is pissed at you don’t know why. Or you just got ghosted on Hinge. Again.
By Sunday roast with the family, you’re at your wits end with the constant bickering.
Relationships. Wherever you go, there they are.
The kicker? You can’t program it into a computer to deal with it. You can’t create a spreadsheet for it. You can’t outsource it.
And even though you know you need to work on how to manage conflict, communicate effectively, and handle your own emotions – contrary to popular belief, knowledge isn’t power.
Your power as a high performer comes from connection.
I coach extraordinary high-performers to increase their performance and power.
I work through a unique creative process that unlocks your emotional intelligence and harnesses the power of relationships to maximise your personal and professional potential.
Having trained as a professional Co-Active Coach at the globally acclaimed Coaches Training Institute (CTI) in London, the leading International coaching organisation accredited by the International Coaching Federation (ICF), I blend Co-Active Coaching, neuroscience, acting, leadership and sales training to create a tailored method based on the organisational and individual needs.

domain: psychology


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Stratigraphy, Sedimentology, and Paleontology
Published:September 07, 2016
The 26.9-Ma Creede caldera is a large resurgent ignimbrite-subsidence structure that hosts world-class epithermal Ag-Pb-Zn deposits set within the San Juan locus of the Southern Rocky Mountain volcanic field (SRMVF). This field guide reviews the understanding of the SRMVF and central San Juan magmatic locus and then provides a summary of the Oligocene Creede Formation, the caldera moat fill, and ancient Lake Creede, which occupied the caldera for ~100 k.y. after the caldera-forming eruption. The summary of the volcanic setting and Creede Formation provides a framework for discussing the hydrothermal system that deposited Ag-Pb-Zn ores in the Creede district ~1.8 m.y. after the caldera formed. This guide also highlights controversial aspects of the Lake Creede environment, such as the duration of the intracaldera sedimentation, proposed pseudomorphs after ikaite (CaCO3·6H2O) in the lake sediments and tufa, and the paleolimnology of ancient Lake Creede.
Figures & Tables
Unfolding the Geology of the West
Prepared in conjunction with the 2016 GSA Annual Meeting in Denver, Colorado, this volume contains sixteen guides to field trips in this rich geologic region. The four “Great Surveys” of the late 1800s ventured west to explore and document the region’s unknown natural resources and collect valuable geologic information. Many of the field guides in this volume, aptly titled Unfolding the Geology of the West, will cover the same hallowed ground as the early geologic expeditions. Organized into four sections, this volume spans some of the major subdisciplines of geology: (1) stratigraphy, sedimentology, and paleontology; (2) structure and metamorphism; (3) Quaternary landscape evolution; and (4) engineering and environmental geology.

domain: geography


- Extend your DB37 cable for more flexibility
- Serial Cable / RS232 Cable
- 6 Foot / 6'
- Lifetime Warranty
Make sure the important files from your CPU are backed up on a regular basis. Extend your cable connection for your tape backup or Bernoulli Box applications for reliable data storage and retrieval. The line of extension and replacement cables is fully shielded against EMI/RFI interference to ensure quality transmissions every time.


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A PREGNANT woman in her 30s has appeared in court charged with the murder of a two-year-old in a Cork city flat last July.
Karen Harrington appeared before a special sitting of Cork District Court on a single charge of murdering Santina Cawley at 26, Elderwood Park, Boreenmanna Road, Cork on July 5 last.
Santina's mum Bridget O'Donoghue and her dad Michael Cawley were in court for the short proceedings.
The court was told that the 35-year-old is four-and-a-half months' pregnant and would require medical attention while remanded in custody.
Detective Garda Cormac Crotty said he arrested Karen Harrington at 7.56am this morning at Lakelands Crescent, Mahon.
He charged her with murdering Santina Cawley and she replied to the charge.
Detective Garda Crotty said: "She replied, 'I do not understand why I am getting charged. I did not murder no-one.'"
Lawyer Paula McCarthy told Judge Mary Dorgan: "I am asking that my client receive every medical assistance.
"She is four-and-a-half months' pregnant."
She said because of the charge they would be leaving the matter of bail to the High Court.
She handed in a statement of means and after reading this the Judge granted free legal aid to Cork solicitor Eddie Burke.
The judge said: "I'm requesting all necessary medical attention be provided for your client.
Harrington who was dressed in a grey fleece hooded top and light coloured pants did not speak during the hearing.
Judge Dorgan remanded her in custody to appear before Cork District Court next Monday August 26.
Two-year-old Santina was found unconscious in the Elderwood Park flats complex and was rushed to Cork University Hospital where she died in her mum Bridget's arms.
MOST READ IN NEWS
She had suffered extensive injuries all over her body. Once Gardai received the results of the postmortem they upgraded their investigation to one of murder.
Supt Mick Comyns who has headed up the murder investigation was in court for the brief hearing.
The toddler's Mass of the Angels at the Cathedral of St Mary and St Anne on Cork's Northside was told she was "God's newest angel."

domain: news


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A long time ago, I traveled in the "Up With People" International Touring Group. For almost three total years, I had the privilege to stand among amazing people from all over the world, travel through the U.S., Canada and Europe, and sing songs of culture, diversity and peace. I stayed in countless host families and participated in a wide variety of community service projects. My love for performing took a far-back seat when I got married and had my two boys. But I sing here, on SingSnap, to remind myself of the joy that singing once brought to my life.
Thank you for visiting my page and taking time to listen to the songs I have recorded. I'll try to rotate out the songs as I edit my voice and bring to you, performances that are from my heart.

domain: artistic


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This restaurant was closed when we arrived and appears to have been closed for quite some time. This restaurant needs to be taken off of open table.
Arrived at restaurant to find it closed for renovations, possibly permanently. Suggest removing this restaurant from your listings for reservations.
This restaurant was closed for remodeling. The website did not indicate that and Open Table let us make a reservation. We arrived for dinner to see a note taped to the door that they were closed for a few weeks. Very disappointing.
My reservation was accepted but when I arrived the entire restaurant was closed for renovations. I had a party of 12 and we completely embarrassed by the situation.
Restaurant is closed. They even sent me a text confirming the reservation. Looks like that have been closed since middle of September. Ended up going to Felicia Suzanne’s and had a great meal. Maybe we will try again if they reopen
The restaurant was closed, drive an hour to eat there and it wasn’t even open. Not sure why I was allowed to make a reservation...
I made a reservation for a birthday celebration. Upon arriving, a sign was posted on the door indicating they were closed for remodeling. Ruined the night! Why would they continue to accept and confirm reservations when closed. Informed Open Table and they were apologetic but the next are still accepting reservations for a restaurant that is closed! Unacceptable.
It was closed! We had the reservation and drove all the way downtown and paid for parking and then it had a sign on the window that it was closed for a few weeks. We were going to celebrate my father's 65th birthday. Horrible experience!
Closed for two weeks for remodeling. You'd think Open Table would let you know that when making reservations.
My guess, from looking at the menu, is the food would be really good. Considering it was closed and under renovation, we weren't able to eat, here. Maybe update your reservation app so that out if towners will know.

domain: food


St.Petersburg, 05 November. On 05 November 1967 the first national strategic nuclear submarine cruiser - Pr.667A submarine К-137 Leninets ("The follower of Lenin") - joined the Navy. It was designed by Rubin Design Bureau.
The Soviet Navy had nuclear-powered ballistic submarines (Pr. 658) also designed by Rubin by the time of completing the К-137 construction. However it is the Pr. 667А submarines that are considered to be strategic underwater missile carriers because their firing range became intercontinental. Furthermore the Pr. 658 ships had only three missiles and those of Pr. 667А carried sixteen units (armament has increased more than fivefold).
For the first time pre-launch preparation in the К-137 submarine and follow-on ships of the class took place automatically. In autumn 1969 the second ship of Pr. 667А - submarine К-140 - fired world's first eight-missile salvo.
Pr.667А was equipped with the first domestic automatic battle management system Tucha ("Thundercloud"). It gathered the environmental information, solved navigational tasks, ensured employment of missile and torpedo weapon.
Diving depth of Pr.667А ships (400 meters) was 1.25 times more than that of Pr.658 (320 meters). The submarines of Pr. 667А became the first ships in the world that dived to that depth. To prevent a depth overshoot which can cause an accident, an integrated automatic control system was implemented in the ships of Pr.667А for the first time. Course and speed programmable control as well as hovering was provided.
Compared to Pr. 658 the submarine cruisers of Pr.667А had a higher level of habitability comfort. The entire personnel were accommodated in cabins or crew quarters of non-multiple occupancy. The mess-hall can be easily transformed into a gymnasium or movie theatre.
The construction of 667А submarines commenced in Severodvinsk at Sevmash. К-137 was laid on 4 November 1964 and launched on 11 September 1966. It was commissioned by the Navy on 05 November 1967.
The series was being built relatively fast: the second boat, К-140, was laid on 19 September 1965, launched on 23 August 1967 and introduced into the Navy on 30 December 1967. Totally 34 ships of Pr. 667А were built: 24 in Severodvinsk (from 1967 to 1972) and 10 in Komsomolsk-on-Amur (from 1969 to 1972).
Series 667А was the most numerous among all the projects of Soviet nuclear submarines. Several modifications were developed on the basis of this Project: 667B, 667BD, 667BDR, 667BDRM (four modifications of Delta-class). Ships of the last two types are now in service with the Russian Navy.
"The upgrading possibilities were initially inlaid in the carrier created by General Designer Sergei Kovalev. Hull, systems and power plant turned out to be capable of accepting more and more "charger clips" of more powerful and longer-range missile complexes," - evaluated in his reminiscences Rear-Admiral Vadim Berezovsky, the Commanding Officer of К-137 Leninets and the Hero of the Soviet Union.
From 1967 when the leading ship and the second Pr. 667A SSBN К-140 were delivered to the Navy to 1990 when the last Pr. 667BDRM was accepted by the Navy, 77 submarine cruisers of second generation under five projects (667A, 667B, 667BD, 667BDR and 667BDRM) were built, i. e. on average over three ships a year. The missile weapons have undergone continual improvements - from a single warhead missile with limited flight range up to a MIRV missile of intercontinental range.
"The establishment and development of Pr. 667А SSBNs has set foundation for the system of naval nuclear strategic weapons as a major source of strategic deterrence," - stated Sergei Kovalev, General Designer, in his memoirs.


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NEW VALIDATED RP-HPLC METHOD FOR THE ESTIMATION OF EMPAGLIFLOZIN IN HUMAN PLASMAHTML Full Text
N. Padmaja 1, Tegene Desalegn 2, Mulagiri Sharathbabu 3 and G. Veerabhadram * 3
Faculty of Pharmacy 1, Department of Chemistry 3, University College of Technology, Osmaina University, Hyderabad - 500007, Telangana, India.
Department of Chemistry 2, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia.
ABSTRACT: A new reversed phase simple, economic and specific validated high performance liquid chromatography method for the estimation of empagliflozin in human plasma is presented. A chromatographic separation was carried out isocratically by mobile phase comprising of methanol and acetonitrile, 50:50% v/v at a flow rate of 1.0 ml/min on agilent long C18 column (250 mm × 4.6 mm, 5 µm) with photodiode arrays (PDA) detection at 270 nm. The bioanalytical procedure involves deproteination of plasma with 30% ethyl acetate and liquid-liquid extraction process. Chromatogram showed a peak of empagliflozin at retention time of 8.898 min. The correlation coefficient (r2) was found to be 0.999 in the concentration range of 50-150 μg/ml. No interference peak was observed in blank plasma samples at the retention time of empagliflozin. The percentage of relative recovery and coefficient of variation (CV %) values of precision and accuracy were within the acceptable limits. The method proved simple, cost effective and sensitive for estimation of empagliflozin in human plasma.
Empagliflozin, Human plasma, method development, Validation
INTRODUCTION: Diabetes is one of the largest world health problems of the 21st century. There is a need for drugs with novel mechanisms of action that can be used alone or in combination with other anti-diabetic agents to improve glycemic control and hyperglycemia is often poorly controlled despite a number of therapeutic options 1 - 4. Unlike previously available agents, sodium-glucose co-transporter 2 (SGLT2) inhibitors offer an insulin-independent mechanism for maintaining blood glucose levels, since they promote urinary glucose excretion (UGE) by inhibiting glucose reabsorption in the kidney.
Empagliflozin is a member of the SGLT2 inhibitor class of drugs being investigated for the reduction of blood glucose levels in adults with T2D 5 - 9.
The IUPAC name of empagliflozin is (1-chloro-4-[b-d-glucopyranos-1-yl] - [4-([s] -tetrahydrofuran-3-yl-Oxy) benzyl] -benzene Fig. 1. The empirical formula is C17H19ClO2Si and the molecular weight is 455.91. Empagliflozin is a white to yellowish, non-hygroscopic crystalline solid. It is commercially marketed under the name Jardiance and marketed by Boehringer Ingelheim International GmbH, Ingelheim, Germany 9 - 12. The drug was approved by USFDA on August 1st 2014 and in Europe in May 2014 10 - 12.
Empagliflozin is not official in any pharmacopoeia. A literature survey on empagliflozin revealed that, until now only few analytical methods were reported for its estimation of empagliflozin such as UV-visible spectroscopy 13, HPLC method 14 - 17 in bulk and API form. To date, there is no RP-HPLC method reported for determination of empagliflozin in any preclinical species and human plasma. Hence, we felt that there is a great need to develop and validate a simple, specific and reproducible, economical LLE-RP-HPLC method for estimation of empagliflozin in human plasma.
FIG. 1: CHEMICAL STRUCTURE OF EMPAGLIFLOZIN
MATERIALS AND METHODS:
Chemicals and Reagents: The empagliflozin authentic sample was kindly provided by Spectrum laboratories, Hyderabad, Telangana, India. HPLC grade acetonitrile and methanol were procured from Rankem, Ranbaxy fine chemicals limited, New Delhi, India. Blank human plasma was procured as a gift sample from the nilourfer hospital, Hyderabad, India. The 0.45 μm nylon membrane filters were purchased from Pall India Pvt. Ltd. Mumbai, India.
Instrumentation and Chromatographic Conditions: The analysis was performed using waters 2695 binary pump with 2996 photo diode array detector used for method development, plasma studies and method validation. The output signal was checked and the acquisition and integration of data was performed using Empower software on a Pentium (Digital equipment Co) computer. A chromato-graphic separation was carried out isocratically by mobile phase comprising of methanol and acetonitrile, 50:50% v/v at a flow rate of 1.0 ml/min on agilent long C18 column (250 mm × 4.6 mm, 5 µm). The mobile phase was pre-mixed, filtered through a 0.4 μm nylon filter and degassed. The flow rate was kept at 1.2 mL. Throughout the LC column oven was maintained at 35 ºC and detection was monitored at 270 nm. The injection volume was 20 μL.
Preparation of Solutions:
Preparation of Standard Solution: Accurately weighed 10 mg of empagliflozin was transferred into 10 ml volumetric flask, dissolved and made up to the mark with diluent. This was a solution having strength of 1000 μg/ml of empagliflozin. From this solution, 0.2 ml of the solution was pipetted out and diluted up to 10 ml to get 20 μg/ml of empagliflozin.
Extraction of Plasma from Blood: Blood was collected into an EDTA containing tube and then it was centrifuged for 10 min at 3000 rpm. Blood was separated into layers after centrifugation. The supernatant which contains stray yellow colour (plasma) was collected and used for sample preparation.
Preparation of Plasma Solution: 0.5 ml plasma sample was deproteinated with 20 μL of 30% ethyl acetate and to this 400 μL of empagliflozin was added and the contents of the tube were mixed on a vortex mixture for 3 min. The tubes were kept in an inclined position on a reciprocating shaker at 100 strokes per min for 30 min. The mixture was vortex-mixed for one min and centrifuged at 4000 rpm for 20 min.
The supernatant was transferred to polypropylene tube and washed with one ml of ethyl acetate by mixing for one min and centrifuging at 1000 rpm for 2 min at 5 °C. The supernatant layer of ethyl acetate was discarded and an aliquot of 20 μL was injected to HPLC for analysis using the optimized chromatographic conditions.
Method Validation: ICH Guidance for industry was followed for validation of the method. Selectivity, linearity, accuracy, precision (within a run and between run), LLOQ and stability were assessed during method validation 18.
System Suitability: System suitability is used to confirm the suitability for the theoretical plates, tailing factor and reproducibility of the RP-HPLC system. Freshly prepared solutions of empagliflozin 20 µg/mL were injected into RP-HPLC system.
Selectivity: Selectivity was observed by comparing the chromatograms of spiked sample and drug free plasma samples. For this purpose spiked sample of empagliflozin (20 μg/mL) and blank plasma samples from 6 different sources were prepared and injected.
Linearity: Calibration standard solutions were prepared in plasma from the working solution. Five calibration curves ranging from 50 to 150 μg/mL were run to establish the linearity by using linear regression analysis. Linearity of empagliflozin was observed in term of coefficient of determination (r2). The concentration of empagliflozin in each calibration curve, the percentage relative recovery and CV (% RSD) were determined.
Accuracy and Precision: Quality control samples (n=5) were prepared at four different levels HQC, MQC, LQC and LLOQ analyzed subsequently to evaluate with-in run accuracy and precision. The concentration of empagliflozin was calculated from a standard calibration curve that was concurrently obtained. Accuracy was analyzed at each level by comparing the observed concentration with the nominal concentration as a mean relative percentage recovery, while precision was observed in terms of % CV.
Stability: Stability of empagliflozin in plasma was observed at HQC and LQC levels. To evaluate stability at room temperature, 5 replicates of both levels were prepared in plasma and stored at room temperature for 24 h freeze and thaw stability was observed after four and thaw cycles. The sample was frozen after each cycle for at least 24 h before thawing. For long period stability HQC and LQC were prepared and stored at -20 ºC for two months.
RESULTS AND DISCUSSION:
Method Development and Optimization of Chromatographic Conditions: Empagliflozin was scanned between the wavelength of 200-400 nm and showed maximum absorbance at 270 nm so it was selected as detection wavelength shown in Fig. 2.
FIG. 2: UV SPECTRA OF EMPAGLIFLOZIN
Optimized Method: In this work to achieve good separation and peak shapes, column like Agilent long C18 column (250 mm × 4.6 mm, 5 µm) having more surface area was tried and there is an improvement in resolution and peak shapes was observed. As the analysis of compounds was needed different mobile phases like phosphate buffer, formic acid and orthophosphoric acid were tried with different pH conditions from 2.0 to 7.0. But, organic solvents like methanol and acetonitrile were showing good separations and less column back pressure. Finally, the best results were obtained by mobile phase composition of methanol and acetonitrile in the ratio of (50: 50 V/V) with flow rate of 1.2 mL/min was selected at the oven temperature of 35 °C methanol and acetonitrile were used as diluents.
FIG. 3: TYPICAL HPLC CHROMATOGRAM OF BLANK PLASMA
FIG. 4: TYPICAL OPTIMIZED HPLC CHROMATO-GRAM OF EMPAGLIFLOZIN
FIG. 5: OVERLAY CHROMATOGRAM OF PLASMA SPIKED WITH EMPAGLIFLOZIN 50-150 µg/mL
The developed RP-HPLC method was found to be highly specific. The representative chromatograms of blank plasma, optimized standard chromatogram and overlay standard chromatogram were summarized in Fig. 3, 4 and 5.
System Suitability Parameters: System suitability method acceptance criteria set in each validation run were: tailing factor ≤ 2.0 and theoretical plates > 2000. In all cases, the relative standard deviation (RSD) for the analytic peak area for two consecutive injections was < 2.0%. Results are tabulated in Table 1.
TABLE 1: SYSTEM SUITABILITY PARAMETERS
|Name||Retention time (min)||Tailing factor (Tf)||Theoretical plate (N)|
Selectivity: All the injections were processed at the wavelength provided in the method. There was no interference observed from diluents blank solutions, excipients blend solutions with empagliflozin peak. Empagliflozin was eluted at 8.898 min. Hence this method is selective.
Linearity: Linearity graph of average area at each level against the concentration in ppm is plotted and is found to be a straight line graph. The calibration curves (n=5) were linear with r2 ≥ 0.999 over the range of 50-150 μg/ml.
TABLE 2: LINEARITY DATA OF EMPAGLIFLOZIN
|Concentration (µg/mL)||Peak area (μV* sec)|
FIG. 6: CALIBRATION CURVE OF EMPAGLIFLOZIN
The value of the slope was 1691.7 and the intercept was 887.1. The correlation coefficient is found to be more than 0.999. The linearity results were expressed in Table 2 and the linearity graph was shown in Fig. 6.
Accuracy and Precision: The mean percentage of relative recovery for within run precision and accuracy were 99.3 % and 103.1% while % RSD ≤ 4.00%. The mean percentage of relative recovery for between run precision and accuracy were 97.6% and 99.5% whereas % RSD ≤ 3.47%. The method has shown consistent and high mean recovery ranging from 98.90 - 99.22%. The precision and recovery results were expressed in Table 3.
TABLE 3: ACCURACY, PRECISION DATA OF EMPAGLIFLOZIN
(Mean ± S.D)
|Within runa (n=5)||0.25 (LLOQ)||0.26 ± 0.001||0.38||101.2|
|0.5 (LQC)||0.575 ± 0.02||4.00||99.3|
|25 (MQC)||25.95 ± 0.212||0.81||103.1|
|50 (HQC)||50.65 ± 0.77||1.52||100.2|
|Between runb (n=5)||0.25 (LLOQ)||0.001 ± 0.26||0.38||99.5|
|0.5 (LQC)||0.56 ± 0.07||3.47||98.6|
|25 (MQC)||25.45 ± 0.494||1.96||97.6|
|50 (HQC)||53.2 ± 0.7||1.31||98.6|
aAnalysed on same day, bAnalysed on five different days
Stability: Empagliflozin proved stable at room temperature for 24 h with a mean percentage recoveries for HQC and LLOQ at 101.5% and 103.5 %, respectively, and a CV≤ 4.08 %. After 4 freeze and thaw cycles, the mean percentage recoveries were 99.6% and 100.0%, respectively, and a CV≤ 2.0%.
TABLE 4: STABILITY STUDIES OF EMPAGLIFLOZIN
(Mean ± S.D)
|Short term stability (n=5)||50 µg/mL (HQC)||49.35 ± 1.34||2.71||101.5|
|0.5 µg/mL (LLOQ)||0.49 ± 0.02||4.08||103.5|
|Freeze –thaw stability (n=5)||50 µg/mL (HQC)||50.8 ± 0.7||1.37||99.6|
|0.5 µg/mL (LLOQ)||0.51 ± 0.01||2.00||100.1|
|Long term stability (n=5)||50 µg/mL (HQC)||50.8 ± 0.70||1.37||98.6|
|0.5 µg/mL (LLOQ)||0.5 ± 0.01||2.00||98.2|
For long-term stability empagliflozin also proved stable with mean percentage relative recovery of 98.2% and 98.6% respectively for HQC and LLOQ while CV≤ 2.0%. Stability data were tabulated in Table 4.
CONCLUSION: This new validated RP-HPLC method for the estimation of empagliflozin in human plasma is accurate, precise, less cost and reproducible. The method described, does not require expensive solvents, chemicals and reagents. It does not involve complex sample preparation or complicated instrumentation. All the validation parameters were within the acceptable limits for estimation of empagliflozin in human plasma. The proposed method can be used for predictable bioanalysis of empagliflozin in various biological samples to support bioequivalence and pharmacokinetic studies.
ACKNOWLEDGEMENT: The authors would like to acknowledge RGNF awarding financial assistance and head, department of chemistry for providing that necessary facilities.
CONFLICT OF INTEREST: The authors did not report any conflict of interest.
- Nair S and Wilding JP: Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus. Clinical Endocrinal Metab 2010; 95: 34-42.
- Mcgill JB: The SGLT2 inhibitor emphagliflozin for the handling of type 2 diabetes mellitus. Diabetes Ther 2014; 5: 43-63.
- KD Tripathi: Essentials of medical pharmacology. New Delhi, India Edition 7th, 2013: 278-279.
- Wild S Roglic G, Green A, Sicree R and King H: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27: 1047-1053.
- Foneca VA, Kikman MS, Darsow T and Robert E: The American Diabete Research Perspective Research Perspective Diabetes. Diabetes 2102; 61 (6): 1338-1345.
- Neumiller JJ: Empagliflozin: a new sodium-glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. Drugs in context 2014; 3: 212-262. doi: 10.7573/ dic.212-262.
- Nair S and Wilding JP: Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus. Clinical Endocrinal Metab 2010; 95: 34-42.
- Dailey G: Empagliflozin for the treatment of type 2 diabetes mellitus: An overview of safety and efficacy based on Phase 3 trials. Journal of Diabetes 2015; 7: 448-461. Doi: 10.1111/1753-0407.12278.
- McGill JB: The SGLT2 inhibitor emphagliflozin for the handling of type 2 diabetes mellitus. Diabetes Ther 2014; 5: 43-63. Doi: 1007/s13300-014-0063-1.
- Volino LR, Pan EY and Mansukhani RP: Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors in Type 2 Diabetes: A Literature Review of Approved Products. Pharmacology & Pharmacy 2014; 5: 1029-1058.
- McGill JB: The SGLT2 inhibitor emphagliflozin for the handling of type 2 diabetes mellitus. Diabetes Ther 2014; 5: 43-63.
- Elizabeth Mechatie for Clinical Endocrinology News Digital Network August 1, 2014 FDA approves empagliflozin for adults with type 2 diabetes.
- Jyothirmai N, Anil Kumar M and Nagaraju B: Novel UV and Visible spectrophotometric methods for the analysis of Empagliflozin a type 2 diabetic drug in bulk and pharmaceutical formulations. Journal de afrikana 2016; 3(1): 177-187.
- Padmaja N and Veerabhadram G: Development and validation of a novel stability-indicating RP-HPLC method for the determination of empagliflozin in bulk and pharmaceutical dosage form. International Journal of Pharmaceutical Sciences and Research 2016; 7(11): 1000-08.
- Shyamala K, Nirmala J, Mounika and B Nandini: Validated stability indicating RP-HPLC method for determination of empagliflozin Der pharma lettere. 2016; 2: 457-64.
- Madhusudan P, Reddy RM and N Devanna: RP-HPLC method development and validation for simultaneous determination of Linagliptin and empagliflozin in tablet dosage form. International Advanced Research Journal in Science, Engineering and Technology 2015; 7: 95-9.
- Swarupa G, Rao L, Prasad and Babu S: Development and validation of stability indicating reversed phase high pressure liquid chromatography method for simultaneous estimation of Metformin and Empagliflozin in bulk and tablet dosage form. Asian Journal of Pharmaceutical and Clinical Research 2016; 9: 126-135.
How to cite this article:
Padmaja N, Desalegn T, Sharathbabu M and Veerabhadram V: New validated RP-HPLC method for the estimation of empagliflozin in human plasma. Int J Pharm Sci & Res 2018; 9(11): 4885-89. doi: 10.13040/IJPSR.0975-8232.9(11).4885-89.
All © 2013 are reserved by International Journal of Pharmaceutical Sciences and Research. This Journal licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.
N. Padmaja, T. Desalegn, M. Sharathbabu and G. Veerabhadram *
Department of Chemistry, University College of Science, Osmaina University, Hyderabad, Telangana, India.
07 March, 2018
16 May, 2018
31 May, 2018
01 November, 2018

domain: literature


text:
SHAHEEN APPLAUDS PASSAGE OF PREVENTIVE HEALTH CARE, MEDICARE PROTECTION MEASURES
Shaheen cosponsored amendments to be included in Senate health care legislationDecember 03, 2009
Washington, D.C.-U.S. Senator Jeanne Shaheen today applauded the passage of two measures she cosponsored to improve health services for women and secure Medicare benefits. The first measure would provide free preventive health services for women, and the second ensures that guaranteed Medicare benefits cannot be cut. Both amendments will now be included in the Senate's Patient Protection and Affordable Care Act, which is currently before the Senate for debate.
"A key component of reforming the health care system is making sure patients have full access to the services they count on to keep them healthy," said Shaheen. "Both of these amendments will help us reach the goals of providing better preventive health care for women and guaranteeing that Medicare beneficiaries will receive the care they need now and in the future."
The first amendment Shaheen cosponsored requires all health plans to cover comprehensive women's preventive care and screenings at no additional cost to women. Women utilize the health care system more than men, and this measure will help reduce the costs women incur on cervical and breast cancer screenings and other preventive services.
The second amendment passed today ensures that no cuts can be made to guaranteed Medicare benefits and that savings found within Medicare will be reinvested in the program. Through increased efficiency, the Patient Protection and Affordable Care Act extends the life of Medicare, removes waste and fraud, lowers costs for seniors, and protects Medicare benefits.
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domain: medical


text:
One way your body offers information to you is through pain response. It’s an effective strategy though not a really enjoyable one. When your ears start to feel the pain of a very loud megaphone next to you, you know damage is happening and you can take measures to move further away or at least cover your ears.
But for around 8-10% of people, quiet sounds can be perceived as painfully loud, in spite of their measured decibel level. Hearing specialists refer to this condition as hyperacusis. This is the medical term for excessively sensitive ears. There’s no cure for hyperacusis, but there are treatments that can help you get a handle on your symptoms.
Elevated sensitivity to sound
Hyperacusis is a hypersensitivity to sound. The majority of individuals with hyperacusis have episodes that are brought about by a specific set of sounds (typically sounds within a range of frequencies). Quiet noises will often sound really loud. And loud noises seem even louder.
Hyperacusis is frequently linked to tinnitus, hearing trouble, and even neurological difficulties, though no one really knows what actually causes it. With regards to symptoms, intensity, and treatment, there is a significant degree of individual variability.
What kind of response is typical for hyperacusis?
In most instances, hyperacusis will look and feel something like this:
- You will notice a particular sound, a sound that everybody else perceives as quiet, and that sound will sound exceptionally loud to you.
- Balance problems and dizziness can also be experienced.
- The louder the sound is, the more intense your response and discomfort will be.
- After you hear the initial sound, you may experience pain and hear buzzing for days or even weeks.
Hyperacusis treatment treatment
When your hyperacusis makes you sensitive to a wide variety of frequencies, the world can seem like a minefield. You never know when a lovely night out will suddenly become an audio onslaught that will leave you with ringing ears and a three-day migraine.
That’s why it’s so crucial to get treatment. You’ll want to come in and speak with us about which treatments will be your best option (this all tends to be rather variable). Here are some of the most common options:
One of the most commonly used treatments for hyperacusis is something called a masking device. While it may sound perfect for Halloween (sorry), in reality, a masking device is a piece of technology that cancels out certain wavelengths of sounds. So those unpleasant frequencies can be removed before they make it to your ears. You can’t have a hyperacusis episode if you can’t hear the triggering sound!
A less state-of-the-art approach to this basic method is earplugs: if all sound is blocked, there’s no possibility of a hyperacusis incident. There are definitely some drawbacks to this low tech approach. Your general hearing issues, including hyperacusis, may get worse by using this strategy, according to some evidence. If you’re considering using earplugs, contact us for a consultation.
One of the most thorough methods of treating hyperacusis is called ear retraining therapy. You’ll use a combination of devices, physical therapy, and emotional counseling to try to change the way you respond to certain kinds of sounds. The concept is that you can train yourself to ignore sounds (rather like with tinnitus). This process depends on your dedication but generally has a positive rate of success.
Less prevalent methods
Less common methods, including ear tubes or medication, are also utilized to manage hyperacusis. Both of these strategies have met with only mixed success, so they aren’t as frequently used (it’ll depend on the individual and the specialist).
Treatment makes a huge difference
Because hyperacusis tends to vary from person to person, a specialized treatment plan can be developed depending on your symptoms as you experience them. There’s no single best approach to managing hyperacusis, it really depends on finding the best treatment for you.


text:
George Kennedy's House
By tlp333 @ 2009-07-08 06:47:53
The Academy Award-winning actor, who has appeared in over 200 film and television productions, lives here. He is perhaps most familiar as Dragline in "Cool Hand Luke", Joe Patroni in the "Airport" series of disaster movies from the 1970's and comedically as Captain Ed Hocken in the "Naked Gun" series of movies.
10.0 (1 votes)


text:
You're browsing the GameFAQs Message Boards as a guest. Sign Up for free (or Log In if you already have an account) to be able to post messages, change how messages are displayed, and view media in posts.
There were no (substantial) mods for ME1. The only modding for a ME game that would really be feasible are uber guns and armor and such. The ME games are so dialogue heavy that I'm not sure I'd want any large new mods. New planets and missions voice acted by the modders and their buddies are not high on my to-play list.
So now you see that evil will always triumph because good is dumb. - Dark Helmet

domain: game


Over the past few years, Netflix has greatly increased its anime library. This includes slightly older series like Death Note as well as newer ones like One-Punch Man, and many of them were popular before coming to Netflix. But there are also Netflix Original anime, which are licensed by and exclusive to the streaming platform. Recent hits include Aggretsuko and Devilman Crybaby, and the catalog continues to grow.
Traditional anime fans are often sticklers when it comes to what can be called "anime." This is especially true with shows like Netflix's Castlevania and the upcoming Cannon Busters, which aren't made entirely by Japanese creators and, to some fans, fall into a hard-to-define gray area. During Anime Expo 2018, we spoke to several Netflix anime creators about what qualifies as anime, how anime is evolving, and more.
Featured in this interview are Castlevania producer Adi Shankar, Cannon Busters showrunner and longtime animator LeSean Thomas (whose previous work includes The Boondocks and The Legend of Korra), renowned Japanese director Shinji Higuchi (whose new series, Dragon Pilot, is coming to Netflix on September 21), and director of anime at Netflix John Derderian. Be sure to read our roundup of Netflix's latest anime announcements for more details on the upcoming series. The following interview has been edited for length and clarity.
I want to start off with something you [LeSean Thomas] said on Twitter very recently about defining anime. I think anime fans are very big on defining what is and what is not anime, and with series like Castlevania and Cannon Busters, that's something certain people get testy about. What does "anime" mean to you as a creator and with Netflix in particular?
LeSean Thomas: I mean I think that's a fascinating question, and it's almost always the case with Americans or Westerners asking other Americans or Westerners what anime is and what it isn't. I have yet to see, at all, anyone asking a Japanese animation director or creator or producer...what anime is, because then that would sort of be counterproductive to their argument of what they believe anime is because of the lens in which they're viewing anime as a descriptor, from a Western point of view. So usually anime is associated with the belief that the animation is only from Japanese creators and Japanese people, all animated by Japanese animators.
It can't be identified as anime as they view it as a Western descriptor unless that's the case. If there's an American creator working with Japanese animators, then this vocal minority that we're already talking about don't view it as anime. So these are arbitrary rules, created to sort of control...or protect, if you will, this sort of identity that they attach to the bodies of works. I mean, it's been a topic of discussion for the last few years with me and other people. I would sort of deflect the question towards [Shinji Higuchi] to see what he would think about that question.
These are arbitrary rules, created to sort of control...or protect, if you will, this sort of identity that [fans] attach to bodies of works.
Shinji Higuchi: It's very difficult to answer. If I'd only worked on anime, I'd probably have a lot more concrete vision about that...When it comes to working on animation, I'm kind of on the [fringes]. So now that I'm producing animation, there's a certain theory to creating anime, but I'm creating this animation [Dragon Pilot] on the assumption, like, how much of that theory I can break.
The protagonist is not the definition of "kawaii" at all. The character, or the protagonist--there tend to be a certain personalities that comes with [that] you expect from the anime characters, but we want to take another look at what it should be when we develop the characters for the show.
John Derderian: [At Netflix], we're trying to enable vision, and it kinda touches on your question [about] people that love anime. Someone on my team that always talks about anime as a "tribe" of people with passion and deep love, reference points, a catalog. You can talk to LeSean for an hour about every reference he has. There's such a love, and [Thomas and Adi Shankar] are a part of that "tribe" of anime and so they can step to the table and make the best anime there is. They can step to the table and contribute to that conversation and that evolution of anime.
But to be clear, Netflix is doing a ton of more traditional, manga- and light novel-based anime and we will continue to do a ton of that. We've invested heavily in Japan, into partnering with the the studios in Japan to basically enable an art form that has been--especially 2D animation, which has been struggling and kind of disappearing a bit. We think it's one of the greatest art forms on earth and we wanna continue to support it, and the home of anime is Japan.
There also seems to be a group of people that are highly attached to simulcast anime rather than the Netflix style of releasing a whole season at once. Like with Little Witch Academia--a lot of people were really upset about having to wait for that show. [Editor's note: Little Witch Academia was released on US Netflix as a full season after the Japanese broadcast had concluded.] Is simulcasting something you consider at Netflix?
Derderian: I mean for us, the challenge with the simulcast window is none of the rest of Netflix is on that window. So it creates little bit of a challenge for us--and we have tried it and we'll probably experiment around it--but overall we'd rather invest and get the best subs and dubs we can get. Let people experience it how they want to, whether they want the dub experience or the subtitle experience, but it does take a couple of months [to produce].
The best [solution] is we're doing a lot of original anime, and in that there is no waiting anywhere. They'll launch in Japan and the US at the same time with all the complements of language assets. We want to invite a lot of people into anime, so dubs are often way to do that, but we also wanna give someone who loves the Japanese voice actors to listen to them and understand that.
Is it a different process working on a typical episode-by-episode TV schedule versus the Netflix-style full-season package?
Higuchi: I really don't have too much experience delivering [a show in package form] except for a standalone movie. So when we create a series that is broadcast episode by episode by episode, we always have to think about how we can keep the audience captured, wanting to know what's next. So we want to keep their interest for a week or so.
So when we produce [a show episode by episode] we can use the user's imagination. So when users finish watching the show, they can kind of use their imaginations about the stories they just watched...That one week [gap] can be utilized very effectively. So when the episode is done, you have [to wait] one week, and then another episode airs...But if we're going to do [in the Netflix style] we won't be able to use that particular method.
When we create a series that is broadcast episode by episode by episode, we always have to think about how we can keep the audience captured, wanting to know what's next.
Thomas: I guess essentially you would associate it with watching a box set of a series that you haven't seen yet. You sit down and you watch them all at once. So what we're doing is we're comparing experiences. I don't think it has any impact on whether the show is good or not, right? ...We are talking about a new form of information sharing, and content consumption weekly is largely rooted by advertising bias and advertisers being able to maintain the draw of a season so that they [can] continue to generate money to sell product. With a packaged deal, it's kinda like buying DVD box sets. So for me, you're getting the same results, you're just getting it over a stretch of time...I guess what we're saying is, "Which one is better? Which one do you prefer?" And I think that it's up to the individual.
Adi Shankar: It's allowing new types of creators and new types of information to get out there globally. It's no mystery why people are abandoning movie theaters, because there's no room for experimentation, you're locked into a format. You're locked into a time length, right? If I describe my day, and you describe your day, and we have the same five seconds to tell that story, it's gonna sound kind of similar. But all of a sudden, if you're like, "Well, can you describe your day with nuance over 10 hours?" All of a sudden, that same story, even if we have the exact same story, we're gonna tell it differently. The beats are gonna move, right? So, it's not even experimentation, it's creating the blueprint for the way stories are going to be told going forward.
The products discussed here were independently chosen by our editors. GameSpot may get a share of the revenue if you buy anything featured on our site.


text: Martinique is an island on the Eastern Caribbean Sea and an overseas territory of France. With its white sandy beaches, clear blue water and green hills it is the picture of a tropical paradise. Enjoy the unique culture of the island with its Creole and French influences and the multicultural cuisine. Visit the Paul Gauguin Interpretation Centre, dedicated to the artist's brief but fruitful stay on the island. Participate in watersports or take a hike through the tropical forest.


text:
Jay G aka Jay MF G
Essential Vitamins Crew
Saturday, October 29th, 2011 at 10:00pm
MaddTat2 / E.V.C. presents . . . The Halloween Havoc Throwdown
@ Ohm Ultra Lounge . . . 948 Main St. . . . corner of Allen St.
- $5 at the door
- costume contests, door prizes, giveaways, art raffles, drink specials
- live music from: Angry Soil, DJ SlobberNozzle, Jay MF G., Mic Excel, & Specill K
- with Mic & Life's video premiere of "Fanta Flavors"
- with hosts Mark Madden, Cove, & DJ Optimus Prime
** don't miss out on THEE HALLOWEEN PARTY of the 716**
** oh yeah . . . NO PRE-SALE TICKET BULLSHIT!!!**
© 2016 eMinor Incorporated
All third party trademarks are the property of the respective trademark owners. ReverbNation is not affiliated with those trademark owners.
Not listening to anything?
Try one of the ReverbNation Channels

domain: entertainment


text:
Randomized clinical trials have demonstrated hyperthermia (HT) enhances radiation response. These trials, however, generally lacked rigorous thermal dose prescription and administration. We report the final results of a prospective randomized trial of superficial tumors (! 3 cm depth) comparing radiotherapy versus HT combined with radiotherapy, using the parameter describing the number of cumulative equivalent minutes at 43°C exceeded by 90% of monitored points within the tumor (CEM 43°C T90) as a measure of thermal dose.
This trial was designed to test whether a thermal dose of more than 10 CEM 43°C T90 results in improved complete response and duration of local control compared with a thermal dose of ! 1 CEM 43°C T90. Patients received a test dose of HT ! 1 CEM 43°C T90 and tumors deemed heatable were randomly assigned to additional HT versus no additional HT. HT was given using microwave spiral strip applicators operating at 433 MHz.
One hundred twenty-two patients were enrolled; 109 (89%) were deemed heatable and were randomly assigned. The complete response rate was 66.1% in the HT arm and 42.3% in the no-HT arm. The odds ratio for complete response was 2.7 (95% CI, 1.2 to 5.8; P ! .02). Previously irradiated patients had the greatest incremental gain in complete response:23.5% in the no-HT arm versus 68.2% in the HT arm. No overall survival benefit was seen.
Adjuvant hyperthermia with a thermal dose more than 10 CEM 43°C T90 confers a significant local control benefit in patients with superficial tumors receiving radiation therapy.


text:
IASO General Clinic offers comprehensive healthcare services for the whole family, complementing the quality level of care provided by the IASO Group.
Prevention & Diagnosis
Taking into account that prevention is the best treatment, IASO General Clinic has set up Outpatient Clinics for all medical specialties and an ultra-modern Check-Up Department. In partnership with the Diagnostic Labs, they are the first allies for early proactive treatment of any possible disease or illness.
Round-the-clock emergency care
The second safety net is that medical emergencies are handled 24/7, with the operation of a fully dedicated department and all main medical and surgical specialties on duty.
Internal Medicine & Surgical Sector
For conservative or surgical treatment of the entire range of conditions, IASO General Clinic has established a fully-equipped Internal Medicine and Surgical Sector, with qualified scientific associates, offering the most modern methods for diagnosis and treatment.
The ongoing expansion of our services in the last 25 years of operation is continuing with the adoption of globally groundbreaking methods and technologies:
- Fully Digital Operating Rooms that incorporate the required technology to create a healthy, aseptic and safe environment, and are compatible with all the latest technology.
- The most advanced Central Sterilizing Department in Greece, which combines the latest technology worldwide, for the purpose of providing the best possible prevention of infections and maximum safety to patients.
- Endoscopy Unit with AI technology for the diagnosis and treatment of all gastrointestinal and pulmonary diseases.
- Robotic neuronavigation system for minimally invasive surgery with maximum safety and intraoperative accuracy in Neurosurgery, Orthopedics, Otolaryngology and Maxillofacial surgery, in real-time 3D.
- The 4th generation da Vinci Xi robotic system which is the evolution in minimally invasive surgery, as it offers three-dimensional imaging of the surgical field, and consequently greater surgical precision and minimal postoperative complications.
- The most comprehensive Radiation Oncology Center in Greece, equipped with four cutting-edge linear accelerators for applying the most appropriate treatment to each patient, and with a High Dose Brachytherapy Unit.
However, the greatest strength of the IASO Group are its people and the excellence of those who make the best of our infrastructure, providing added value and results to every service provided to our patients.


text:
LILLY HASWELL REMEMBERS EVERYTHING --- WHETHER SHE WANTS TO, OR NOT ...
Lilly toils in her father's apothecary shop, preparing herbs and
remedies by rote, she is haunted by memories of her mother's
disappearance. Villagers whisper the tale, but her father refuses to
discuss it. All the while, she dreams of the world beyond --- of travel
and adventure and romance.
When a relative offers to host her in
London, Lilly discovers the pleasures and pitfalls of fashionable
society and suitors, as well as clues about her mother. But will Lilly
find what she is searching for --- the truth of the past and a love for
I felt this novel was a time-machine drawing me back to Jane Austen's regency era in the most fabulous way.
four possible suitors for Lilly's hand were intriguing. There's the
gruff, rakish son of the local nobleman, who frightens everybody. Then
there's a timid, but thoughtful young doctor with self-esteem and
confidence issues. Third is the rival apothecary who sets up in
opposition to her father, and has an undeniable Casanova appeal.
Finally, there's her father's former awkward apprentice, who has grown
to be unexpectedly quite dishy. I wasn't taken by surprise by her final
choice. He's the one I would have chosen too and I was cheering him on
all the way. The fact that he was also athletic and handsome was just a
bonus. He and Lilly were the perfect match in principle and integrity.
What I appreciated about her was the way in which she knew her London
'season' was probably over for good but chose to stay at home because it
was just the right thing to do. She was richly rewarded.
book highlights what really matters in life in a beautiful,
easy-to-swallow way. I found Lilly's relationship with her father and
her brother, Charlie deeply moving too. I noticed some reviewers
expressed disappointment with the way the mystery about Lilly and
Charlie's mother was wrapped up, but I thought it true to life.
""POSSIBLE SPOILER"" A guinea pig may have been harmed within the pages
of this book,
The Apothecary's Daughter available from Amazon

domain: library


People see technological advancements in the elevator and escalator industry by embracing IoT and smart building technology.
FREMONT, CA: Elevators and escalators have facilitated vertical expansion over the years, critical to the urbanization of the world's fast-paced cities. Elevators and escalators have developed into a necessary component of everyday transportation. Elevators and escalators have evolved significantly over the last two decades. The Internet of Things (IoT) and smart building technology have had a transformational effect on this sector.
Advances in IoT and smart building technologies have expanded the utility of elevators and escalators beyond their primary mechanical function of quickly and comfortably transporting people up high-rises. They are growing more sophisticated as they link to the cloud platform, which stores their data following analysis. Predictive maintenance is critical for IoT usage in the elevator and escalator industry. Frequently, maintenance can cause disruptions in the flow of people within buildings, particularly during unexpected breakdowns. Elevators and escalators, in such instances, can instantaneously communicate real-time performance data and conduct predictive maintenance via IoT without the need for human intervention.
Additionally, smart building technologies enable the mobility of people to be smooth, safe, and efficient. Elevators and escalators with intelligent controls are the future of vertical mobility. They quickly discover technological issues and make maintenance decisions. In general, elevators and escalators will have a life of their own in this age of smart buildings.
Elevators are evolving to increase utility and speed of movement to keep up with superstructures. The following are some significant developments in the elevator industry.
Elevators to Reduce Travel Time: Due to the heavyweight of steel rope, elevators with traditional cables have a limited travel distance of only a few hundred meters.
For instance, a KONE UltraRope is ultralight and dramatically enhances travel distance by eliminating cable weight and friction. It is composed of a carbon-fiber core covered by a proprietary high-friction coating and weighs approximately one-fifth the weight of a comparable standard steel rope. As a result, elevators require less energy than regular wires, allowing them to move more quickly.
Elevators with a High-Speed Capacity: Leading manufacturers are developing high-speed double-decker and high-rise elevators that provide rapid, comfortable rides while being extremely eco-friendly. These svelte elevators drastically shorten travel time, allowing for a more efficient flow.
Elevators Without Touch: One of the most intriguing thoughts to emerge from the pandemic is the concept of touchless technologies. The elevator industry is pioneering a range of health and well-being solutions that have significantly aided in creating safer user journeys and healthier places within buildings.
Users can use the touchless elevator call feature to summon an elevator without touching potentially contaminated buttons or screens. Physically separating elevator floor stickers and adjusting the elevator's full load limit help to a healthier atmosphere by reducing crowding.
Elevators that are digitally connected: Elevators will now change with use for a building's life, with digital connectivity as a standard. With pre-programmed themes featuring selected music and animated lights, Ecosystem partners, an information screen, and touchless signaling, elevators are future-proofing buildings with market-leading elevator technology.


text:
About our Bed & Breakfast
Along River Ridge B & B is a all-season restful retreat, a romantic hideaway, and a quiet & quaint getaway.
Rest & renew in the tranquil backyard haven with the Bow River at your door step & our "garden of delights" - water features, gazebo, patio's, hammock, hot tub, lounges, perennial garden & flowers in season
Savor the Sights, Sounds & Scents of a unique blend of urban and rural.
Enjoy a truly indulgent experience that rejuvenates spirits, Soothes souls and bonds friendships.
Treat yourself to our large, luxury Royal room- King size bed -Deluxe Pillow top, Sealy Posterpedic mattress, "finest" of linens, bedding, towels, duvet,bathrobes Fireplace, mood jacuzzi tub, walkin steam shower, heated bath floor, private ac/heat unit,gorgeous stain glass fan with remote, large screen tv, blue ray player, stereo room sound, walkin closet, fridge, wine cooler, telephone, ipod station, private balcony, sky light & window shutters.Complimentary beverage bar.
Superb Water filtering, Softener+Conditioner in B&B.
Or book the "Touch of Country in the City suite". An ideal environment for 2 couples or a foursome travelling or vacationing together or meeting here in Cagary. A spacoius 1300sq. ft. accommodation awaits you. A cozy quest lounge with wood burning fireplace, book,music & movie liabary, billiards table,water cooler, complimentery beverage bar,cheerful solarium
2 charming bedrooms with ensuites - queen size bed -pillow top mattress,telephone, cable TV, high speed wireless, wifi,electric wall fireplace,bathrobes & slippers This can also be booked as separate bedrooms -sharing quest accommodation.
Guest computer, printer, copying, fax, fridge, microwave, barbeque, separate heat control,ceiling fans,dimmer switches, private entrance, free parking,
Come, Relax & have a memorable stay. Excellent attention to detail. Marvelous breakfast. Numerous personal & pampering touches. Extensive guest amenities, facilities & services are available for our guests Welcome to Along River RIdge Bed & Breakfast.
A deposit of 1 night is required for 1 night stay at time of booking and a 50% deposit is required for multiple night booking. When deposit is made, reservation will be secured. Extra person charge is $20 per night.
A deposit will be refunded in full on a single room if it can be rented at 14 days less administration fee of 15%
On multiple room night a deposit will be returned at 14 days if room can be rented less administration fee of 15%. A no show will be charged 1 night deposit on 1 night booking plus $25 administration fee and a multiple room booking will be charged 50 % for a no show.
Well Suited For
Info for Along River Ridge Bed and Breakfast last updated on: Saturday, August 29, 2020
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domain: travel


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In recent months, the situation is still the same. FC Barcelona’s finances are catastrophic. Before the return to power of Joan Laporta, the club culé officially announced that its financial liabilities (i.e. all the debts blaugrana) amounted to 1.173 billion euros, or 15% more compared to the 2018/2019 season. . But that’s not all. The posted net debts were € 488.4 million and those to credit companies went from € 72.3 million to € 279.3 million.
Staggering figures due in large part to the huge shortfall caused by the health crisis and the closure of stadiums to the public (no more ticket office or museum revenue). And yet, that does not prevent the Catalan dailies from mentioning the possible arrival of Erling Haaland. A rumor which is surprising when we know that such an operation represents a total cost (transfer fee, commissions, salary) estimated at several hundred million euros.
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Depreciation that is very expensive
Today, it therefore seems more likely to see a Sergio Agüero free of any contract land than the Norwegian striker Borussia Dortmund. Especially since Goal explains that culé training is faced with a huge puzzle. The media recalls that the club’s payroll represented almost 70% of the total budget, long before the pandemic. Or the limit set by La Liga and UEFA. Since then, the Covid-19 has been there and Barça’s income has fallen sharply. From then on, the payroll became a big problem.
To avoid the worst, the Culés reached an agreement to spread the payment of wages. But that’s only delaying the deadline. Faced with the financial concerns of its teams, La Liga announced in March the salary limits (revised downwards) set for each team of the first and second division. Thus, Barça cannot spend more than € 347m per season. This includes fixed salaries, bonuses, bonuses and amortization of transfers, among others. And it is this last point that poses a problem.
Barça absolutely must sell
As a reminder, the annual cost of the amortization of a transfer corresponds to the amount of the transaction divided by the number of years of the contract signed by the player. Clearly, if you recruit an element for € 50 million and he signs a five-year lease, the cost of the annual depreciation is € 10 million. And in this little game, Goal points out that Barça is supposed to pay 186 M € by June 30! A significant amount due in large part to the very expensive transfer costs of Antoine Griezmann, Philippe Coutinho, Ousmane Dembélé, Frenkie De Jong or even Miralem Panic (around € 110 million out of the € 186 million mentioned above ). And that’s not all.
In addition to these 186 M €, Barça must also pay the current cost of the payroll (around 215 M € specifies Goal). Result: FC Barcelona will spend more than the 347 M € authorized by La Liga. Consequence: the Spanish League will not sanction clubs stuck in such a situation. On the other hand, the excess expenditure recorded will affect the expenditure limit set each year by the authority. In short: if Barça spends € 50m more than the authorized € 347m, it will have to deal next season with a lower spending limit of € 50m (€ 297m instead of € 347m taking the example of the amount of this year). Faced with this terrible observation, and before talking about an arrival of Halaland at Camp Nou, FC Barcelona has no other choice but to sell several items this summer.


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Use this 18 degree circle segment ruler set to cut 20-petal round or pointed Dresden Plates from strips with no waste of fabric. Or sew together five segments to create round or pointed fans. Each petal can be cut up to 8-1/2 inches to create Dresden Plates up to 16-1/2 inches. A circle template for the center is included. It comes with fully illustrated step by step instructions or view the video demonstration.
The ruler slides easily over the fabric until pressure is applied. Then, our exclusive gripper holds the fabric in place while cutting, eliminating slipping and miss-cuts!
Total Size - Wedge 3in x 9in & Circle has 3in diameter
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We love Fabric! As we collect new pieces we will be sharing them here. Feel free to customize your fabric size. If you are looking for bundles, we have those too! We have bundles already put together with some quilt ideas for you.
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Designing a computer rack is one of the most popular past time of all do-it-yourselfers. In this article, we would deal with the various things that are to be considered to get the best rack while designing one at home.
Always look out for proper cable management so that power is distributed safely to your computers. Always make high capacity connections so that they are able to meet the power needs of the whole rack. You may use rackmount powerstrips for the purpose.
Proper Mounting Holes:
Computer racks also differ from each other as per the
Proper Space for Accessories:
Designating proper space for computer accessories in your computer rack is very important. So, please keep this in mind while designing a computer rack at home. There should be proper space for the keyboard, mouse, and video display in your rack. Additionally, there should also be space for placing tape drives or tape libraries in accessible positions.
If you are putting sides and doors on your computer rack, it is important that you consider the airflow needs of your hardware. Some considerations of a self-designed rack incluce proper cooling elements such as vents and fans to take away the excess heat. While fixing these cooling options keep in mind factors like amount of air passing across the device’s surface, differential between the air temperature and the temperature of the device and so on.
Keep these things in mind when you design a rack and you will have a low cost yet efficient way to house your hardware.

domain: design


Motherboard D850EMD2L µATX RDRAM with Audio + Lan 10pk
The Intel® Desktop Board D850EMD2 harnesses the advanced computing power of the Intel Pentium® 4 processor. Designed for the Intel® 850E chipset, the Desktop Board D850EMD2 utilizes the full bandwidth and performance in the Pentium 4 processor with dual RAMBUS* channels and brings Hi-Speed USB 2.0 connectivity to the desktop. The Desktop Board D850EMD2 offers Intel’s highest performance platform solution on the mPGA478-pin package and supports the latest Pentium 4 processors. This provides unprecedented system efficiency and responsiveness for those who wish to stay on the cutting edge of the business world.
Intel D850EMD2L M-ATX, Intel, LGA 775 (Socket T), 2 GB, Network adapter - Ethernet, Fast Ethernet, Micro ATX, ATX
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Whether you are in a relationship or perhaps not, warning flags are a thing that you should know regarding. They can help you decide if you want to keep the romantic relationship how to go from online dating to real dating or break it off.
In a german mail order brides relationship, each one should be remedied with dignity. It is important to grasp your own requirements and the requires of your partner. The partnership should also contain a balance https://www.digitalinformationworld.com/2019/01/how-much-time-do-people-spend-social-media-infographic.html of electric power. When both people are cheerful, the relationship ought to continue.
One of the biggest warning flags in relationships is if you certainly are a victim of emotional misuse. This can possess a negative influence on your self-esteem and could lead to despair. It is important to seek professional help as you feel like you have already been abused.
Another red light in a romance is if you are always caught becoming dishonest. In case you catch your lover dishonest, it is a good idea to slice off get in touch with. This is important to stop further problems.
Another relationship red flag is if your partner refuses to communicate. This may be a sign that they can don’t trust you. They might want to interrogate you or regularly check on you.
Other red flags in romances include extremely controlling behavior. This might come from an associate who is jealous of additional relationships and would like to control you. It could also come from an associate who is planning to convince you that they can be spending too much time with friends.
One of the quickest red flags to identify is a spouse who is inferior. If you consult your partner a question and they aren’t answer, it is a good idea to slice the relationship off.


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Rightsizing for Retirement
What does your home really cost?
Have A Question About This Topic?
This video discusses issues related to your retirement accounts when you move on from your job.
Some may leave their future to chance but in the world of finance, the effects of the "confidence gap" can be apparent.
In the event of an unforeseen accident or illness, disability insurance may be a good way to protect your income and savings.

domain: economics


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Check out the real-time updates about the top 20 best-selling items on HORIZON FARMS.
Translated from Japanese: I put great importance to protein and safety.
For New Year's, I’m having luxurious Tasmanian salmon sashimi with the usual high-protein blue hake.
Translated from Japanese: Blue hake is low in calories and can be expected to have protein and a certain amount of vitamin D ❗
Very pleased with the quantity and quality of this order! There was no fishy smell. I pan fried the fillets and the fish meat held together, did not break up. Most importantly these are delicious! I used simple spices like salt, pepper, turmeric and paprika, and it was just so good that I immediately placed another order!
Translated from Japanese: It has no unpleasant smell, so even I, who is not good with fish, enjoyed it. Since it has no bones, it can also be used for baby food.
I will order again.
Translated from Japanese: It has no smell and you can eat it daily. Delicious ❗
Translated from Japanese: I was looking for free-range meat that was at least a little guilt-free and safe for my body.
It was delicious.
Thank you for your products.
Translated from Japanese: Recently, when I started thinking about animal welfare and researching various things, I found out about "HORIZON FARMS".
I was especially looking for chicken and wanted to try the chicken from "Bostock Brothers Farm" who grew up in a wonderful environment! That’s why I bought it
I thought that the feelings for life, the environment in which they grow, the feed make it a wonderful farm.
Without a doubt, it was the most delicious and safest chicken I have ever had.
I would like to thank everyone at "Bostock Brothers Farm" and everyone at "HORIZON FARMS". Thank you for making such wonderful meat available in Japan.
Translated from Japanese: It was refreshing and straight-up delicious. Perfect for chicken ham.
Translated from Japanese: Knowing the current situation of Japanese broilers, I searched for chicken that is raised more freely.
I found Horizon Farms and bought it immediately.
I bought a lot, but first I got this chicken breast meat.
It’s very juicy and delicious. Thank you.
From now on, I will order this again if I want to eat meat.
Translated from Japanese: The New Zealand lamb I received last time was very delicious, so I ordered chicken this time.
Overnight, I soaked it in salt and stevia to make chicken ham. I was surprised to hear that the breast meat is a chicken that exercises a lot and very soft nevertheless. Especially, the fat part of the thin skin is exquisite.
Thank you to Mr. Chicken, Mr. Bostock, Mr. Horizon for bringing this organic, delicious meat from far away to Japan.
Translated from Japanese: The berries are small but sweet and very delicious. Above all, I’m surprised that my bowel movement has improved tremendously.
Translated from Japanese: I first learned about wild berries on this site! They were sweet and delicious, and I felt that safe and organic fruits were more delicious. My children also love them, and I laughed when I saw the purple color after they ate them.
I want to continue ordering for me and my children’s health.
Translated from Japanese: At the supermarket in my neighborhood, only large ordinary blueberries are sold, so I was looking for these and bought them right away. I made a smoothie with banana and milk for breakfast and drink it every day.
Can these blueberries be used to make jam? They’re dark in color and contain a lot of nutrients. My children often eat them frozen. I eat them with honey and yogurt.
Translated from Japanese: Very fresh and delicious blueberries. I will buy them again.
Translated from Japanese: I’m ordering again.
It’s the only delicious chicken that can be eaten by families who don’t like chicken. I’m happy that it’s safe and organic.
Translated from Japanese: It's soft and juicy.
I think it's real chicken that is simply seasoned and flavorful.
Translated from Japanese: The texture, flavor and taste are very good. The chicken I ate in a restaurant after this was smelly and had a bad texture, so I couldn't eat it.
Translated from Japanese: At first, I was worried about what foreign organic chicken would look like, but although they taste a little different from domestic chicken, they're rich in flavor and delicious. Even if they're grilled or boiled, they'll become very soft if cooked well. The drumsticks were delicious, but these boneless thighs have been my favorite lately, so I’ve been reordering them.
Translated from Japanese: I was very happy that the size turned out to be larger than I expected! I think I will continue to order here.
Nothing beats these burgers - and I had many in my life. Thank you for bringing quality products to Japan.
Translated from Japanese: Arrived after two days.
Grilled one (patty) in a frypan.
Used the second patty to break it into pieces for minced beef.
Translated from Japanese: It’s meat of really good quality that is very delicious when you grill it with only salt and pepper! That’s what my children say.
It’s relieving that the meat is simple and organic.
Translated from Japanese: I baked them in the oven together with vegetables, and after putting melting cheese and tomato on top, I turned the heat up for a few minutes. I also lightly put salt on top. It was a burger that works well with simple seasoning, has a rich flavor and chewy texture. Even though it’s a hamburger, the meat is amazingly firm and was very delicious.
I think I will order again.
Translated from Japanese: This is our go-to store. The meat is really delicious with just salt. I was impressed the first time I had it and thought “this kind of delicious meat exists?” Once I’m running out of them, I will order again.
Translated from Japanese: I was looking for sugar-free, additive-free bacon and found it here. It's delicious, with a nice salty taste. It's a little inconvenient for a small family because it comes in one bag of 300 grams, but a 100 gram unit would be helpful.
Translated from Japanese: The flavor and the texture, all in all, the best bacon. They’re delicious when they’re crunchy. if you cook them on one side until the oil seeps through and turn them around, you can use the same frypan to quickly make eggs at the same time, which I really like. Without getting burned, the fat turned half transparent, which made it look like it had lots of collagen, which is a good thing!
I will stock up on them.
Translated from Japanese: Smoked with garlic and salt and pepper, it was the best.
Usual bacon has sugar in it and there’s no information on the meat’s origin, so I had the feeling of not really liking it, but this bacon saved me.
Neither sugar nor other additives were used, the bacon is made out of real meat. I’m really thankful for this!
This is with no doubt the best bacon I’ve ever eaten. Because frozen products are convenient, I want to always have some in stock!
Of course, I will order again.
Translated from Japanese: When you cook it, it becomes really crispy and with pepper on top it was really delicious. Because there was no sugar used, I think the flavor was really clear. I’m also glad about the simple packaging. I was looking for meat where the animals’ environment was taken into consideration and that’s how I ended up here. I haven’t had anything else but this bacon yet, but I’m looking forward to the other products.
Translated from Japanese: Reaaaally delicious. I ate the bacon with eggs. It seems to be addicting.
Translated from Japanese: I cooked them in a frypan and then put them into a lentil stew. Without adding salt to the lentils, I ate it together and the perfect degree of spiciness was amazing.
Because the skin is thick, it’s very elastic, so there might be people who can’t bite through it with their teeth (I took a big bite). But if you properly use a knife and fork, you can eat with no problems. It might be better to cook the sausages on low flame until the skin is slightly burned. I didn’t cook them the way you can see them in the pictures on the website.
I will order again!
Translated from Japanese: Perfect degree of spiciness. For me, the saltiness was a little too much.
Translated from Japanese: Because of corona, I can’t go out, so I think having a BBQ can be fun. Spicy sausages and beer, there’s no better combination. The outside is crispy, there’s a prickling sound when you bite into them and the inside is juicy. Delicious~! These are big, filling sausages that are perfectly meaty. I want to try country style sausages next!
Translated from Japanese: For those who love meat. The herbs and the Italian flavor are amazing, it made me think “This is awesome!” I might order them again.
Translated from Japanese: They're delicious, but the seasoning is lacking. It’s not the spiciness, but the Italian spices that are missing.
Coming from the west one tends to do without when it comes to certain traditional foods. This is the best breakfast sausage I have tasted in years. The bonus is that you can make a perfectly sized patty out of two sausages for the perfect egg and sausage sandwich.
I will be ordering again!
Translated from Japanese: They’re naturally without skin, but these are soft and easy to eat. It has just the right amount of salt and you can smell the herbs well. At times when you don’t want to eat more than two sausages, if you just cut open the package, you can conveniently separate them in their frozen state.
Without oil, I slowly cooked them with their own oils and eggs. It was extremely delicious!
I want to stock up on them in my freezer.
I need to buy a bigger freezer!!!
Translated from Japanese: It was delicious. Although these kind of sausages are usually very salty, these were just right.
Delicious product! Easy to make a quick and tasty meal!
I was lucky enough to try these earlier and they were fantastic. Both variants are really excellent better than anything you can find in your supermarket.
Translated from Japanese: The flavor is really strong, delicious and because it’s minced meat, when you make hamburgers out of them, they don’t become dry. I’m really glad I can eat this kind of chicken breast.
Also, although it’s soft, the meat also sticks together properly, it’s like you’re not having minced meat, which is a good point.
I will keep stocking up.
Translated from Japanese: It has a relieving feeling that I can eat delicious meat that was raised free-ranged and healthily. Because the package content is a little big, I think it would be good if just half of it was sold separately.
Translated from Japanese: I easily made hijiki (edible seaweed) burgers.
According to the sloppy recipe, I put everything in a bag and mixed the ingredients, after that I put it in a frypan and cooked it like this. Easy!!!
The flavor of the chicken is good, the texture is good and it was really delicious!
I’m thanking you from the bottom of my heart for providing organic, delicious meat.
Translated from Japanese: It was soft, excellent texture. As expected, the chicken is of high quality and delicious, too. I will order again!
Translated from Japanese: I ordered again. I'm thankful to you for giving a peaceful environment to eat in. I could feel you packed my order with care. Thank you ver much.
Translated from Japanese: It was more than I expected. After thawing, I only added salt and pepper and garlic powder and mixed it. A delicious hamburger without sauce was made.
Translated from Japanese: I save it in tupperware for busy times
I put it in fried rice or sprinkle it on a salad
I order it every time because it can be used widely
Wagyu beef that does not use hormones or other drugs is deliciously enjoyed
Translated from Japanese: I was really relieved that no hormones or antibiotics were used.
There was no unpleasant smell or fat in the meat, and the food became very delicious.
I will order again (* ^^ *)
Translated from Japanese: It's like minced lean meat, and it's low in fat. It seems that the breeding is well-managed, so you can eat it with no worries!
Translated from Japanese: Ground beef can be used to make things like hamburgers or meat sauce, so it’s really convenient. This New Zealand ground beef is healthy because it’s grass-fed, so when you make a sauce with it, it’s sweet and really delicious. When you compare the price of this product to the others, it’s a little cheaper, so I want to thank you for providing this.
Translated from Japanese: I purchased the 300g size before the renewal. The inside of the wings and the base of the wings were about half-half in a well-balanced manner.
This time, I slowly simmered the meat in soy sauce, brown sugar and a large amount of ginger. I didn’t mind the smell of the meat and the oil content was refreshing, and the concentrated taste and spiciness of the meat. The ginger and the meat’s broth were delicious and filled my stomach and heart with happiness. After that, I added the remaining bones and radish to the remaining broth and simmered it further, but the radish soaked with plenty of deliciousness was the best.
Many of Horizon farms' products are really attractive, but this product is one of my favorite products that I would like to order on a regular basis ♪ Thank you very much.
Translated from Japanese: I am grateful for this product because chickens raised on homemade feed are unlikely to be found in Japan.
I also keep chickens as a hobby, but considering the time and effort required for one chicken to grow up, I am grateful for this price.
The taste was also delicious!
The meat was very tender and just fell off the bone. It was easy to eat. I recommend this product!
Translated from Japanese: I boiled the whole pack in a pan and then baked them in a frying pan. They were delicious!
Translated from Japanese: I enjoyed the nostalgic taste of Australia! I will order again!
Translated from Japanese: This is my first purchase because there was no use of hormones or antibiotics, and no use sugar either. Normally, I avoid sausages with a lot of additives, but for the first time in decades, I received a safe and secure processed food. There was no strange coloring or unpleasant taste, the taste of the meat was simple. I boiled them, but the salty taste was just right.
Translated from Japanese: When I carefully read the instruction manual that came with my luggage, it said that it could be re-frozen if it’s thawed in the refrigerator (*). In the previous review, I wrote that if you are a single person, you cannot use all 4 sausages at once, but you should refreeze them. I'm sorry. I give it five stars without complaint.
Translated from Japanese: Even organic sausages often use sugar, so it’s helpful these here aren’t. I baked them over low heat according to the cooking example of Horizon Farm. I ate raw sausage for the first time, but they’re softer than I expected. I also got the impression that they stick together. If you open the package, you have to take out all four at once. I'm a single person, so even if I unzip it, I can't use it all at once. It would be better to have one or two packs for singles.
Translated from Japanese: I've always wanted to eat sausages, and I've been looking for something that can be eaten even with allergies and low blood sugar. I don’t have any postprandial symptoms and they’re delicious. The boiled juice make a delicious soup. I want to buy them again.
Translated from Japanese: I don't see many organic chicken sausages around. I also thought it’s amazing that there was no use of starch. It has a strong spice flavor. I boiled and ate them with kale and they were very delicious.
Translated from Japanese: They’re very tasty. I will order again.
Translated from Japanese: It is lightly seasoned and very delicious. One piece is big with a lot of volume.
Translated from Japanese: I haven't had sausages for a while because I'm refraining from meat other than chicken, but I jumped on these because they’re chicken. The scent of herbal spices is strong, so children may or may not like it, but for adults they’re a big hit! I am planning to order a second time.
Translated from Japanese: It was delicious with plenty of spices.
I didn’t like the bacon which is common on the market because of its unique sweetness, but this is meat with condensed flavor!
It was firm even when fried.
Translated from Japanese: The bacon was thick and seasoned well. It was delicious whether eaten as it is or put in soup or with pasta. When I put it in spice curry, it got even more delicious and my family told me that it was tastier than usual.
Translated from Japanese: It's well seasoned, so you don't need to season it when you fry it with vegetables, so it's perfect for busy mornings!
Translated from Japanese: Even if it was baked crispy, it was thick and I loved the seasoning.
It is additive-free and can be eaten with no worries. It can’t be helped that I will order again.
Translated from Japanese: It's solid and thick, and it's full of satisfaction! It was well received by the whole family! The bacon itself is very delicious, so it was delicious without any special seasoning when frying with vegetables!
Translated from Japanese: The natural flavor of the pork itself and the smoked flavor are exquisite and really delicious. I received thick slices, but the balance of the spices suit thin slices better.
Translated from Japanese: Delicious! I will buy it again. I will buy it for my friends.
The texture is like ham. It tastes very meaty. The spices are just right.
Translated from Japanese: I bought it because I wanted additive-free bacon. The taste is very delicious and I would like to order again.
Translated from Japanese: I tried it for the first time, but I am very satisfied with the price for a product without additives.
It has a nice scent of smoke right when you open the package.
Translated from Japanese: It's very delicious, so I’m ordering again. It’s bacon that cannot be bought at supermarkets.
Translated from Japanese: It was delicious with a very gentle taste. You can verify the origin of the ingredients and because high quality chicken was used, you can eat with confidence. You can't get a frozen meat pie like this anywhere else. The volume was solid, and I was full with this alone. It’s a meat pie that you want to keep in stock.
Translated from Japanese: Chicken pie with a natural and gentle taste. There wasn’t a strong taste of unnatural seasonings, so it was very delicious.
I don’t like green peas, but I could eat this pie without the green peas interfering with the taste of other ingredients.
My family is a family of three, so I'd be happy if there were three sold together.
Translated from Japanese: When using my oven, after 35 minutes, the dough on the side of the pie was still white even though the upper part was brown already, but it was delicious anyway. The dough is crispy and the contents are delicious with the scent of laurel, and when you don't have time to cook, you can have it with either salad or soup as a full meal.
If you have lamb sheep meat or minced wild boar, I will buy it!
I would like you to sell frozen puff pastry made from organic flour and butter in the future. You can't go shopping too far in times of Corona, so if you have pie dough made from organically grown ingredients online, you can always make tart with fruits ... Chicken liver pie wrapping ... Please consider it!
I love chicken pies and these certainly did not disappoint, from the flaky pastry to the rich, very tasty filling! Highly recommend these delicious pies!
Translated from Japanese: One pie is enough to fill you up. The taste was not too strong and it was very delicious.
It seems to be very useful for holiday brunch, and it’s a nice product to have in the freezer.
I want to order it again in the future.
Translated from Japanese: I ate it as shabu-shabu. It was delicious, so I'd like to give it 100 points, but the paper that separates each slice of meat stuck and tore the meat, and it was difficult to peel off, so I'll give it 98 points.
Translated from Japanese: I had it as shabu-shabu.
The flavor was very strong and it was really delicious. There is also an oily part, but it’s not heavy and we ate one pack completely.
I'm wondering if, when eating out, shabu-shabu is still good!
I recommend any meat from Horizon Farms, but especially this one.
Translated from Japanese: The meat is good, soft and tasty. It was really delicious. It’s cut in thin slices and there’s one piece of paper in between every thin slice, so it’s really easy to use.
Actually, I think it’s better to wait properly, but because I was in a hurry and wanted 4 slices, I removed the first on top and the last on the bottom in the frozen state easily.


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