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I'm really enjoying the F2K creative writing course through Writer's University. The lesson this past week was all about senses Besides the normal - hear, see, taste, feel and smell - Bob came up with 3 more: Sense of Time (a song, a place, a specific time period), Space (open room, close cove, busy street), and Unknown (danger). We have to come up with 8 sentences which implied and didn't include the specific sense words. Plus one paragraph that included all the sense without saying what the sense is. Then let your fellow classmates identify which senses you used. Here's mine:
She danced in the chair, her head bobbing to the beat, her fingernails tapping the scarred table top in an out of sync rhythm that struck him as discordant until he recognized the sequence.
Sage’s belly tightened as her leg muscles turned to rubber when she saw who stood outside her door.
The pearl white light, filtered through the blinds, gave her the impression of prison bars across the chair.
She eyed the green liqueur and took a small sip, gagging at the blend of licorice and spices.
She covered her nose as the overwhelming odor of unwashed bodies and the copper tinge of blood hit her when she walked up to the open door.
She stumbled, dropping the flashlight and sank to the ground as the pitch black darkness of the cave weighed down upon her.
She smiled when she heard the Cat Steven’s song blaring from the radio for it reminded her of high school buddies whom she hadn’t thought of in years.
She nibbled on her lip, catching it between her teeth, not knowing how to respond to his question.
Lucy stepped aside at the entrance to Martinique’s as two women, arms linked, weaved out of the door of the restaurant. The red head gave her a brilliant smile, then uttered soothing noises, as her brassy voiced companion continued her story at the top of her lungs. “Then he had the audacity to..to..to” She waved a hand, long lacquered fingernails barely missing Lucy’s face. “Think I’d go along with his insane ideas. Can you imagine…” Her voice cutting off as the door swung shut behind Lucy, enclosing her in the tiny foyer. She wrinkled her nose at the lingering sweetness of the woman’s perfume. She stepped through the foyer door into an overwhelming world of voices and music in the cavernous warehouse restaurant. As she waited for her eyes to adjust to the dim light, she smiled at the song playing on the jukebox. Lucy in the sky with Diamonds. He’s here. She inhaled the heavenly scent of garlic, onions and peppers sizzling in the open grill. She felt a hand brush her shoulder. She turned and there he stood. He always took her breath away. She rested a hand again his chest, pressed a kiss to his check, his five o’clock shadow tickling her lips.
This week the task is to take a paragraph from Poe' s A Tell Tale Heart or Faulkner's A Rose for Emily and rewrite it in a different Point of View. 1st person if written in 3rd and visa verse. I love both these selections, especially A Rose for Emily, so fun, fun, fun. This class is really testing my creativity.
Still reading Writing begins with the Breath and since I'm in prep mode for Nanowrimo, just got the writer's workbook Ready. Set, Novel! by Chris Baty, Lindsey Grant and Tavia Stewart-Streit. I love brainstorming.
My goals are simple this round - write every day. Anything beyond that is gravy.
Check in with my fellow ROWer's here and give them some encouragement.
The road leading to a goal does not separate you from the destination; it is essentially a part of it. ~Charles DeLint


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Just days after President Joe Biden made promises on the international stage that the United States is on board to destroy the domestic fossil fuel industry, the largest auction of offshore drilling operations in history is taking place thanks to a 13-state lawsuit that challenged Biden’s executive order to halt all oil and gas operations on and offshore public lands.
The lawsuit, led by Republican Louisiana Attorney General Jeff Landry, resulted in a federal judge in that state issuing an injunction to halt Biden’s effort and the resulting historic auction.
Newsweek reported on the development:
The sale—Gulf of Mexico Outer Continental Shelf Oil and Gas Lease Sale 257—involves 80 million acres, or around 125,000 square miles, an area big enough to fit in all but five U.S. states. By comparison, New Mexico’s land area covers about 121,300 square miles.
Up for grabs is the right to build platform rigs up to 231 miles from shore and drill for oil at underwater depths of up to 11,000 feet. The deal would produce an estimated 1.12 billion barrels of oil and 4.2 trillion cubic feet of natural gas over the next five decades.
The federal court in Louisiana first issued an injunction in June.The administration has appealed the judge’s ruling, but agreed to go forward with the leases while the dispute goes through the courts.
“It was a big victory but a small one at the same time,” Louisiana Solicitor General Elizabeth Murrill told Newsweek.
“The Biden administration has attacked the entire fossil fuel industry and that has enormous long term implications for our state and other states,” Murrill said.
“We think it was entirely ill advised (for Biden) in his first week in office to launch an attack on the fossil fuel industry, including natural gas, which is an important bridge fuel if you are wanting to move significant reductions in emissions,” Murrill said.
Newsweek reported that 267 organizations signed a letter last week asking Biden to halt the sale. The groups want the Department of Interior to examine what they claim is the latest evidence on climate change and the impacts of lease sales to the Gulf’s environment.
A Kansas student newspaper also reported on the huge move to increase domestic energy production:
“This lease sale is an important victory, not only for the 250,000+ oil and gas workers in the state but for every American who is facing high energy costs as a result of our diminished oil and gas supply,” Louisiana Oil & Gas Association President Mike Moncla said in a statement.
“We look forward to working with Attorney General Landry as we continue our opposition to the Biden administration’s failed energy policies that undermine our nation’s recovery from the COVID-19 pandemic,” Moncla said.
The American Petroleum Institute (API) President and CEO Mike Sommers warned of increased energy costs and inflation if the restrictions continue.
“Gasoline and other energy costs are a key pressure point for household budgets,” Sommers said on Oct. 28 during a House Oversight Committee meeting. “Inadequate energy supplies [could] further strain individual households, erode consumers’ broader purchasing power, and threaten jobs as well as the broader economic recovery, contributing to inflationary pressure. Pain at the pump hurts American consumers.”
“Wednesday’s lease sale will be the first of the Biden administration and the eighth offshore sale under the 2017-2022 Outer Continental Shelf (OCS) Oil and Gas Leasing Program,” the student news outlet reported.
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domain: economics


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domain: medical


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Nzulenzu Tour: Explore The Unseen Parts
- Ghana, Takoradi
Nzulezu is a remarkable community situated on stilts above Lake Amansuri in the Western Region of Ghana. This UNESCO World Heritage Site offers a unique and unforgettable experience for travelers seeking to explore an off-the-beaten-path destination. The journey to Nzulezu begins with a scenic canoe ride across Lake Amansuri. As you approach the village, you’ll be amazed by the sight of houses built entirely on stilts, reflecting off the calm waters of the lake. Upon arrival, you’ll have the opportunity to immerse yourself in the local culture and discover the daily lives of the people. Take a tour through the village, walking along the narrow wooden walkways that connect the houses. Learn about the history and significance of Nzulezu from knowledgeable locals who are proud to share their heritage with visitors. Visiting the Nzulezu Cultural Center is a must-do activity, as it provides a deeper understanding of the village’s history and traditions. For nature enthusiasts, Nzulezu offers opportunities to explore the surrounding natural beauty. Enjoy a canoe tour around the Lake, where you can admire the stunning scenery. Overall, a tour of Nzulezu is an extraordinary adventure that combines cultural exploration, natural beauty, and a glimpse into a way of life that is truly unique. It is a journey that will leave you with lasting memories and a deeper appreciation for the diversity and resilience of Ghana’s cultural heritage.
A day trip to Nzulezu
Morning: – Meeting at Takoradi Mall Depart early in the morning to ensure enough time to explore Nzulezu. – Enjoy a scenic canoe ride to reach Nzulezu, taking in the beautiful landscapes along the way. Arrival in Nzulezu: – Upon arrival, you will be guided through the village. Take a walk on the wooden walkways that connect the houses, allowing you to explore the unique stilt architecture of Nzulezu. – Visit the village school and interact with the children, gaining insights into their education system and daily routines. Lunch: – Enjoy a delicious local lunch prepared by the locals, featuring fresh ingredients sourced from the nearby river and surrounding farms. Afternoon: – Engage in cultural activities and workshops, where you can learn traditional crafts such as basket weaving or pottery-making. – Immerse yourself in the vibrant music and dance traditions of Nzulezu by participating in a traditional performance. Evening: – Before leaving, take some time to relax and watch a mesmerizing sunset over the lake, creating a picturesque ending to your day trip. – Bid farewell to the locals and express your gratitude for their hospitality. Departure: – Depart from Nzulezu back to Takoradi Mall. Note:Please note that this itinerary may vary depending on the specific activities and events available at the time of your visit.
Meeting And Pickup
Takoradi Mall, Independence Avenue, Takoradi
This tour ends back at the meeting point.

domain: geography


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Green Port Hull
The site is the location for Siemens offshore wind operations, which includes a blade manufacturing plant and a turbine assembly facility
Alexandra Dock is located on the estate of the Port of Hull and offers quayside access. Immediately to the north of the site is Hedon Road, the main arterial route for docks traffic to the motorway network.
Enhance Capital Allowances, with Assisted Area
Planning consent granted for B1, B2 and B8 uses


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Info about Jaama, Ida-Virumaa (Estonia)
Jaama is a town of Ida-Virumaa, Alutaguse vald, in Estonia (EE).
Also called Jaama, Vihtse, Vikhtse, Yama, Яама, its latitude is 59.0416700, and its longitude 27.7119400.
In Jaama are located 80 people, its timezone is Europe/Tallinn (Europe/Tallinn_cet).
In Jaama you can do mosques, shopping, bars, museums, boat rides, food, disco, wine bars, pubs, casinos, statues in Estonia.

domain: travel


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Bleacher Report Scores $10.5M
San Francisco-based Bleacher Report, which publishes and syndicates fan-generated sports news online, said yesterday that it has completed a $10.5 million Series C financing round. Crosslink Capital led the round. Bleacher Report previously raised $7.3 million, in a June 2009 round led by Hillsven Capital. The site claims to be the Web’s fifth largest sports media destination, with more than 16 million monthly unique visitors.


Let’s start with a definition. This one from Margaret Rouse of whatis.com.
“The internet of things, or IoT, is a system of interrelated computing devices, mechanical and digital machines, objects, animals or people that are provided with unique identifiers and the ability to transfer data over a network without requiring human-to-human or human-to-computer interaction.”
In short, we can track, send or receive information from just about anything from anywhere, and/or to just about any appliance or machine to just about anywhere. It is a daunting thought. We reviewed a half dozen videos and selected this one as a good 3-minute overview with good visuals.


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This is a series of illustrations done for the packaging of “Trash Wheels”, funny cars to collect, which fits in nicely with the rest of the “Trash Pack”, from Moose Toys in Australia.
The 2D painting is done by Oscar Ramos
He was responsible for making the “render” (2D painting as always) of the drawings that sent to him from Moose. He had a fabulous time working with the talented artists and loved the art direction of Moose Toys.
Done in Photoshop.
Lovely right? But at first glance its really gross. Share your insight, leave a comment below

domain: design


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22 Aug 2019
Formation Center for Salesian Brothers of America Board of Governors Meets
(ANS – Guatemala City – August 21) – On August 19-20 the board of governors (curatorium) of the Formation Center for Salesian Brothers of America (CRESCO) met. At the institution nine Salesian coadjutors from seven provinces are trained. One is Bro. Rafael Vargas from the New Rochelle Province (kneeling, 7th from right). Leading the meeting were Fr. Natale Vitali (standing, 6th from left), general councilor for the America South Cone Region, and Fr. Tim Ploch (standing, 4th from right), councilor for the Interamerica Region. Fr. Tim Zak (standing, 6th from right), New Rochelle’s provincial, participated.


Crews will be working on area roadways including general maintenance projects, but there are also operations that will impact traffic.
Area engineer Mike McGrath talks about projects scheduled for his district.
Other projects in the area include…
On I-35 from the DeKalb-Clinton County line to mile marker 68, north of Winston, crews will be conducting a resurfacing project Monday through Friday.
Route OO will be closed from Kodiak Road to County Road 212 for culvert replacement Tuesday through Friday from 8 a.m. to 3 p.m. each day.
Route NN will be closed from County Road 300 to County Road 292 for culvert replacement as well. Work will be done Wednesday and Thursday from 8 a.m. to 3 p.m. daily.
On U.S. Hwy 36 Eastbound from U.S. Hwy 69 to Sale Barn Road crews will be doing pavement repair Monday and Tuesday and will include a 10.5-foot width restriction.
On I-35, from the DeKalb-Clinton County line to mile marker 68, north of Winston in Daviess Co. crews will be performing a resurfacing project all week.
Route W will be closed from Hedge Road to Baker Road for culvert replacement on Thursday from 8:30 a.m. to 3:30 p.m.
Route W will be closed from Cook Road to NW Heron Road for culvert replacement on Friday from 8:30 a.m. to 3:30 p.m.
Route B will be closed at the Locust Creek Bridge, until further notice.
Route M will be closed from Route O to Route C for culvert replacement Monday through Friday from 8 a.m. to 3:30 a.m. daily
On Route 129 From Bucklin to Route J, crews will be doing shoulder and sidewalk work Monday through Friday.
Route Y will be closed from County Road 190 to County Road 520 for culvert replacement Monday through Wednesday from 8 a.m. to 3:30 p.m. daily.
On Route V at the railroad bridge in Chillicothe near Broadway and Polk, crews will conduct bridge maintenance Monday through Friday.
And in all counties on various routes, crews will conduct sign operations, bridge maintenance, mowing, pothole patching and drainage work throughout the week.
For full information about work on all of Missouri’s roadways, log onto the MoDOT website.


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Money-back pledge for Cinderella Man
Russell Crowe at the premiere of Cinderella Man.
In a rare marketing ploy, the number two US movie theatre chain, AMC Entertainment, is offering a money-back guarantee to customers for boxing picture Cinderella Man, to boost interest in the struggling film amid a record box-office slump.
Advertisements offering on-the-spot refunds to AMC patrons began running on June 24 in newspapers and on the exhibitor's website AMC spokeswoman Pam Blase said today.
The ads, welcomed by the film's distributor, Universal Pictures, say in part: "AMC believes Cinderella Man is one of the finest motion pictures of the year!"
Blase said AMC provides occasional rebates to dissatisfied moviegoers on a case-by-case basis. But the Cinderella Man offer marks the exhibitor's first money-back guarantee since Mystic Pizza, Julia Robert's breakout 1988 film.
"This is highly unusual," said Paul Dergarabedian, president of box office tracking service Exhibitor Relations Inc. "That's putting your money where your mouth is."
The major studios and theatre owners have now posted 18 straight weekends of year-to-year declines in ticket sales, the longest slump since analysts began keeping detailed box office tallies. Some industry observers have attributed the slump in part to a string of films widely regarded as subpar.
Starring Russell Crowe as the Depression-era boxing hero Jim Braddock, Cinderella Man has received generally favourable reviews but fallen flat at the box office.
The movie, which cost a reported $US88 million ($115.33 million) to make, opened the weekend of June 3-5 and has grossed a lacklustre $US49.8 million ($65.27 million) through its fourth weekend.
Executives at Universal, a unit of General Electric Co, have acknowledged they took a gamble releasing a period drama aimed at adult moviegoers early in a summer movie season awash in high-octane popcorn fare targeting younger audiences.
Blase said the AMC has not decided how much longer to keep Cinderella Man in theatres, a decision that Universal said was up to individual exhibitors at this point.
The number of refunds requested since the promotion began has been "minuscule," but no figures were yet available, Blase said. Nor was there any way to tell whether admissions to Cinderella Man have risen since the offer began, she said.

domain: entertainment


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Turn the other cheek is taken to enjoin becoming a doormat for jesus, to be trampled without protest give your undergarment as well has encouraged people to go limp in the face of injustice and hand over the last thing they own. Demonstrations against the election of donald trump as president continued around the country early friday, taking a decidedly violent turn in portland, ore, where police made several arrests. He told blacks that get smacked to turn the other cheek -tupac shakur, on 2pacalypse now, track 6, words of wisdom the march on washington for jobs & freedom stunned the nation with 300,000 protesters in 1963 and, by '69, the record was pushed to 500,000 by the moratorium to end the war in vietnam. Did the sermon on the mount really promote ''turning the other cheek'' beliefnet the mount provided the foundation for their political protests but non-violent form of protest.
All i'm saying is turn the other cheek, fine, but sometimes if you keep turning the other cheek all you do is get bruises more and at some point, you have to say enough is enough, lemon said as. Better turn the other cheek: the tragedy of electoral boycott and protest lindberg, staffan i lu ( 2004 ) at the panel opposition politics under electoral authoritarianism, american political science association (apsa), 100th annual meeting. Banish any thought of turning the other cheek in the coming fight over justice anthony kennedy's replacement on the supreme court a political strategy based on.
Turning the other cheek or an eye for an eye september 17, 2012 was the one-year anniversary of the occupy movement, and sadly enough it was a sentimental fare illustrating not only the good intentions but also the enormous limitations of the movement. Turning the other cheek - what to tell your kids about campus area protests risks and more unfriendly political climate advice to avoid any protests. If the democratic party is going to become relevant again outside of its coastal redoubts, it has to start winning some elections — and turning the other cheek on this court fight is not the way. Jesus said love our neighbors as ourselves but never told caesar how to run rome-he never said roman soldiers should turn the other cheek in battle or that caesar should allow all the barbarians to be roman citizens or that caesar should tax the rich to help poor.
Turning the other cheek - what to tell your kids about campus area protests part of the point of holding and participating in the counter-demonstrations is to. Political debates have been a key component in the american presidential races and other political races for decades turning the other cheek on morning. What's right only to convince you to turn the other cheek and endure starvation so as to get your pie in the sky when you die taking aim in particular at the salvation army (which hill called the. Christian group plans 'revival' to protest 'toxic evangelicalism' never said roman soldiers should turn the other cheek in battle or that caesar should allow all the barbarians to be.
Turning the other cheek is a dignified expression of a tradition of faithful protest that recognizes the sovereignty of all human dignity and the inherent majesty of all human beings and personality we need today more voices for change and peace. Tag: protest turning the other cheek partisan politics, a hyped media, the distortion of facts, and a lack of honorable political discourse ruled the day. In consequence, these conservative commentators advise us to remain above the fray, and thus turn the other cheek—so the leftist media can kick the other side of our butt. But history suggests that, for most protest movements, violence is counterproductive: those that turn the other cheek, opting for civil disobedience, sit-ins and strikes rather than armed. Sonny carson and the politics of protest how an angry young man became a political power broker that turn the other cheek business—shee-it malcolm, i.
Don't tell other people how to protest anti-trump protesters were expected to turn the other cheek, to be the bigger person i learned how to avoid political. In other words, i believe god sent me to the white house the very spiritual don lemon then twisted scriptures in order to rebuke the pastor all i'm saying is turn the other cheek, fine, but sometimes if you keep turning the other cheek all you do is get bruises more and at some point, you have to say enough is enough. Local press reports that a man was arrested tuesday for throwing manure at the restaurant during a protest other, in turning the other cheek, in doing good to those who persecute you. What does it mean to love your enemies and turn the other cheek does that encourage your enemies this seems to go against survival what is the relationship between survival and the above.
Should israeli officers turn the other cheek has a long history of violent protest - came out of the house to help her daughter assault and verbally abuse the. How walter wink confronted violence was his interpretation of jesus' saying to turn the other cheek and other sayings in the gospel of matthew. Even when confronted with violence, practitioners figuratively and sometimes literally turn the other cheek and love, instead of hate, those who wrong them the montgomery bus boycott became king's first opportunity to use nonviolent direct action. But king did not believe the christian idea of turning the other cheek applied to social action until he studied the teachings of mahatma gandhi, who introduced the weapon of non-violence during india's struggle for independence from great britain.

domain: politics


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Suffering from an undiagnosed illness and kept away from the mountains this spring I’ve had the opportunity to read a good number of books in addition to wasting too many hours playing DOTA 2. Here are some micro reviews:
God is not Great, by Christopher Hitchens: A Christmas gift from a relative, the late Hitchens’ tear down of religion (all religion, not just Christianity, mind you) was my first reading after plowing through the first four A Song of Ice and Fire (Game of Thrones) books. Written in classic polemic style, it is concise, easy to read, and absolutely one sided. Even-handed this is not. Yet that is the point of a polemic: to make the case that your argument is so strong that there is no other argument to consider, no valid opposing point of view. Although his vitriol is tiring on occasion, that his arguments should be considered by believers and atheists alike cannot be denied.
The Strangest Man: The Hidden Life of Paul Dirac, Mystic of the Atom, by Graham Farmelo: Most laymen with an interest in modern physics or its development are familiar with many of Paul Dirac’s results and innovations: the Dirac equation, the Dirac delta function, bra-ket notation, the prediction of the anti-electron (positron), and so on, and yet most of us have little awareness or understanding of Dirac’s life and personality. In this book, Farmelo does a great job showing Dirac’s troubled upbringing, struggles to succeed as a young adult, supreme awkardness in his personal relationships (hence “The Strangest Man”), fame and triumphs in his 20s and 30s, and acolyte of the quest for truth in mathematics through his later years. The book is occasionally dense, and sometimes a little dry, and probably couldn’t be enjoyed without a prior interest in Paul Dirac, but for those interested in the early development of quantum theory this is a great book.
Wolf Hall, by Hilary Mantel: According to the front cover, Hilary Mantel’s Wolf Hall won the 2009 Man Booker prize, but I respectfully disagree as to its quality. A fairly long tale told from the perspective of Thomas Cromwell set in the middle years of King Henry VIII’s reign, a complex web of relationships is developed, but little empathy is developed and the plot plods along ultimately going almost nowhere. For a more interesting yarn involving the same characters (and more!) I would suggest instead watching Showtime’s TV series “The Tudors”.
CUDA Programming: A Developer’s Guide to Parallel Programming with GPUs, by Shane Cook: In my real life as the lead developer for a high-performance in-memory database and analytic engine, I’m frequently asked whether any of our calculations could be optimized by running them on GPUs instead of CPUs. Consequently, I used my time on a recent trip to Texas to read Shane Cook’s introductory book on programming GPUs with CUDA and found it to be very enlightening. Nothing can compete with raw experience, but for a quick head start on developing with CUDA (only for nVidia GPUs), this book does a really good job at explaining the necessary concepts and developing examples to show fof the various capabilities and pitfalls of GPU programming. A few more examples of converting real world algorithms to work on GPUs would have been appreciated, but there’s always trial and error in Visual Studio to figure that out…
The Power of Now, by Eckhart Tolle: I’ve struggled these past few months to come to grips with a long lasting illness, and at times felt a need to seek help working through things. Through this process, I was recommended two books by Eckhart Tolle, and read this one first. Written in question and answer format, the book is structured as a long conversation between the reader and Tolle himself, working to guide the reader to understand the importance of “now”, and how “now” is the only thing that ever is. Regardless of what happens or what has happened, you are living “now” and all that is not “now” needs to be dealt with rationally and minimally. Personally I found this book very helpful, and that’s pretty much all that can be said about it. Some people would probably find it fluffy and just a bunch of mumbo jumbo, as would I have a year ago, but if you’re struggling to come to terms with something in life, this book is a powerful kick in the pants to get mentally back on track.
A New Earth: Awakening to your Life’s Purpose, by Eckhart Tolle: Unlike “The Power of Now”, Tolle’s “A New Earth” is much less focussed on becoming mindful about “now” and living focussed solely on your current being, and instead focusses on the matter of ego and how it affects oneself as well as humanity in general. The points he makes are interesting and seem quite valid, but for me this book lacked the poignancy and power of his previous book. Furthermore, a few sections veer just a little too close to “mumbo jumbo” when he starts discussing things beyond the self. Not bad, but not great either in my mind.
Buried in the Sky: The Extraordinary Story of the Sherpa Climbers on K2’s Deadliest Day, by Peter Zuckerman and Amanda Padoan: One of the constants of popular Himalayan mountaineering literature is that it’s told from the perspective of the visitors: the North Americans, Europeans, Japanese, and Koreans who visit the Himalaya each year to climb and conquer its mighty peaks. Nonetheless, there are few expeditions to the Himalaya that don’t have Sherpas or other high altitude porters (HAPs) assisting them all the way from the valleys to high camps, and often all the way to the summit. These Sherpa climbers support expeditions, save lives, and die on the mountains just like white people do, and it is their story that Zuckerman and Padoan bring to life in this book. A remarkably quick read, requiring only a few hours, their book vividly tells the story of climbers like Chhiring Sherpa from their upbringing in tiny villages to their involvement in the tragedy that unfolded on K2 in August 2008. Well written and brief, this book fills its niche well and we can hope that more stories in the future share the perspective of the local climbers and guides and not just the visitors with the money to pay for the expeditions.

domain: library


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Author pages are created from data sourced from our academic publisher partnerships and public sources.
Pilot-scale chitin extraction from shrimp shell waste by deproteination and decalcification with bacterial enrichment cultures
- M. Bajaj, Andrea Freiberg, J. Winter, Y. Xu, C. Gallert
- Chemistry, Medicine
- Applied Microbiology and Biotechnology
- 31 July 2015
Extraction of chitin from mechanically pre-purified shrimp shells can be achieved by successive NaOH/HCl treatment, protease/HCl treatment or by environmentally friendly fermentation with… Expand

domain: chemistry


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- The Food Network Kitchen app offers virtual cooking classes to users.
- I took one of the free baking classes with Alex Guarnaschelli as the featured chef.
- The class got me to make something I wouldn't have otherwise tried, but having it on my phone was a little frustrating at times.
- Regardless, it was a fun activity, and the Parker House rolls came out better than I expected.
- Visit Insider's homepage for more stories.
I prefer cooking to baking because cooking is less rule-based and there's a lot more room for human error. Baking requires acute attention to detail, math, and precise and proper measuring. For this reason, I stick to baking things that either come in a box or bag and require little extra ingredients, or I try recipes that look like they have larger margins for messing something up.
As I and many others around the country stay home in self-quarantine, I decided to finally try out the Food Network Kitchen app I had downloaded months ago. One of the app features is virtual cooking classes with some of the network's biggest stars.
The free classes on offer were all focused on baking, so I took this opportunity to try my hand at being a chemist in the kitchen (waking up yeast seemed like more of a chemistry experiment than anything else I've done in the kitchen). I chose to try celebrity chef and "Chopped" judge Alex Guarnaschelli's recipe for Parker House rolls.
While I had some trouble getting the hang of watching the tutorial on my phone, it was a fun experience and my rolls came out better than I thought they would.
I was able to download the Food Network Kitchen app from the Apple App Store for free, and there were five featured classes I could take without paying.
The Food Network Kitchen app has a ton of different features — like access to certain cooking shows and recipes. One of them is virtual cooking classes taught by Food Network stars.
While the app is free to download, anyone who wants to have complete access — commercial-free episodes of Food Network shows, unlimited cooking classes, live Q&As with network chefs, and skill tutorials — needs to subscribe for a fee. Users can choose to subscribe on a monthly basis for $6.99 per month before taxes.
I was able to access five complete classes — all of which were focused on baking — and save other recipes to my profile for free.
I chose the Parker House roll recipe from "Chopped" judge and chef Alex Guarnaschelli.
I was given a choice between classes for Parker House rolls, s'mores cookies, mirror glazing a cake, rainbow layer cake, and chocolate cream pie with whipped peanut butter cream.
I had never made bread before (and the Parker House roll recipe seemed to require the fewest number of ingredients) so I figured now was my time.
The app lists ingredients and tools you'll need to execute the recipe.
I was able to look at the ingredient list on the app and check them off as I put them in my shopping cart, which was helpful.
I was also able to uncheck each item when it came time to make the recipe and recheck them once I had measured each one out and set it aside.
Through the app, I was able to watch Guarnaschelli make her recipe while I made mine at the same time.
I loved that I was able to reference Chef Guarnaschelli's technique throughout the entire process. I got to see what my dough should look like at different stages as well as how fast or slow she had her mixer spinning.
I also found it helpful to hear her talk through everything she was doing.
I thought it was frustrating to have to constantly pause and play, rewind and reload the recipe while my hands were filled with dough.
Every time I wasn't sure of something, I'd rewind or pause the video and take a second look. I also paused while it took me a little longer than Guarnaschelli to do any given step.
While having the ability to pause and rewind was really convenient and helpful, it was a little hard to do while my hands were covered in dough.
Ultimately, my rolls came out better than I thought they would.
I had messed up a little when I activated the yeast because I forgot that I had halved the recipe. But it didn't seem to affect the rolls all that much.
When I flattened the dough, mine looked to be more sticky and less solid than Guarnaschelli's, but the rolls still came out OK. They weren't as perfectly shaped as hers were, but they fluffed up and tasted good.
If it weren't for this virtual cooking class, I probably wouldn't have tried to make them at all.
One of the many reasons why I love taking cooking classes is that they get me to make something I wouldn't have made otherwise.
For me, this experience was exactly that. I love to cook more than anything — having fun in the kitchen is definitely my preferred way of relieving stress. But it turns out, baking actually makes me more stressed.
I find myself constantly turning back to the list of steps and doing frustrating math as I try and cut or double a recipe. I probably wouldn't have ever attempted to make something where I had to activate yeast like I did for these rolls.
I found it helpful to have the video of Chef Guarnaschelli to reference, and I was pleased with the finished product.
I wouldn't take one of these online classes again for baking, simply because it required me to rewind and pause too many times. But, I would look into taking a cooking class where I could be more lenient with ingredients and rules, which I think would make it easier for me to follow along.
If you're going to try out one of these classes, I would recommend watching the entire video through once before starting, and then watch it again as you make the food. That way, you'll go into the process with a little more understanding of what you're about to do, how you'll get there, and where you need to end up.

domain: hobby


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Ashfall Mobile Gam Apk is a third-person shooter MMORPG set in a post-apocalyptic world. In the near future, humanity must survive a nuclear war started by an AI seeking revenge. Your goal as the protagonist of this story is to find the origin of creation to save the world.
In Ashfall, you control a character, customized to your liking, who explores abandoned cities, barren deserts, and ancient battlefields... a post-apocalyptic in-game civilization. while saving A realistic and intense RPG experience,Ashfall Mobile Gam App features stunning 3D graphics and a dynamic weather system as well as intense physics as you battle enemies.
In the world of Ashfall Mobile Gam Apk you can find all kinds of mutants created by the outbreak of the nuclear war that caused everything in this world. As always in shooting video games, here you will find all kinds of futuristic weapons to consider in the game for the gaming experience you want. The map is full of cover and buildings that will help you choose the best battle strategy on the battlefield.
This Apk can be played alone and with friends, which adds to the game's gameplay. And beyond that ambitious title, Oscar-winning composer and music producer Hans Zimmer is responsible for transporting us to the land of Ashfall.
What is Ashfall Mobile Game Apk?
Ashfall Mobile Game Apk mobile game is a unique gaming experience that gives players the opportunity to embark on an adventurous journey in a post-apocalyptic world. The game features a third-person shooter MMORPG genre and sends players into a perilous future after a vengeful nuclear war is unleashed by the AI.
Explore the world of destruction:
Ashfall Mobile Game App embarks on a magical journey through abandoned environments, weeds that have invaded once-occupied cities, and lands left behind after the war. Players are free to create their own characters, customize them as they wish, and immerse themselves in a world full of mystery and danger.
Weapons and battlefields of the future:
In Ashfall Mobile Game App you will face challenging and dangerous situations. With a diverse selection of futuristic weapons, you will feel the thrill of every battle. The battlefield map requires you to make smart strategic decisions to defeat your enemies and advance on your journey to save the world.
Ashfall Mobile Game Apk Game Download not only provides a diverse gaming experience with an interesting story but also allows you to play with friends. You can join friends on a journey that has one goal: save the world. Additionally, the game's music was distilled and composed by renowned composer Hans Zimmer, adding vibrancy and charm to the ravaged world of Ashfall.
Let's fight, explore and save the world together in Ashfall Mobile Game Google Play APK!
Features of Ashfall Mobile Game Apk
Post-Apocalyptic World: The game takes players to a post-apocalyptic world after a nuclear war. Players will explore abandoned environments, ruined cities, arid deserts, and former war zones, creating a unique and inspiring setting.
Character Customization: Players have the ability to fully create and customize their characters. From appearance to traits, you can create a unique character based on your personal preferences.
Futuristic Weapons: In the world of Ashfall, you have the opportunity to use a variety of futuristic weapons to deal with different situations. From handguns to heavy weapons, you must make wise decisions to defeat your enemies.
Strategic Battlefield: On the huge battlefield map, players must make the right strategic decisions to win. You have to understand the terrain, find the enemy's weak points, and choose the right strategy.
Immersive RPG Experience: Ashfall Mobile Game App offers an authentic RPG experience that lets you develop your character by leveling up, customizing skills, and collecting gear.
Single and Multiplayer Play: You can start the journey alone or team up with friends. In multiplayer mode, you can interact with your friends and form teams to complete difficult challenges.
Unique Music: The game is accompanied by unique and catchy music composed by famous composer Hans Zimmer. Music adds vibrancy and substance to Ashfall's devastating world.
Immersive Physics and Weather System: The game world features a dynamic weather system that creates dynamic and time-varying environments. The intense physics system in combat helps you feel the thrill and realism.
Captivating Story: The game features a deep and captivating story about finding the origin of creation to save the world from danger.
How to download and install the Ashfall Mobile Game Apk file?
Here are some frequently asked questions:
Download Ashfall Mobile Game APK is located in the Strategy category and was developed by NetEase Games's. The average rating on our website is 4.8 out of 5 stars. However, this app is rated 4 out of 5 stars according to different rating platforms. You can also respond Ashfall Mobile Game APK on our website so that our users can get a better idea of the application. If you want to know more about Ashfall Mobile Game APK, you can visit the official developer website for more information. The average rating is rated by 1298 users. The app was rated 1-star by 22 users and 5-star by 249 users. The app has been downloaded at least times, but the number of downloads can reach . Download Ashfall Mobile Game APK If you need a free app for your Action device, but you need 5.0 version or higher to install this app.


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Rock gardens are a timeless testament to the beauty of simplicity. These miniature landscapes offer a harmonious blend of rugged charm and effortless elegance, perfectly tailored for those seeking a serene oasis within the confines of their personal space.
With their low-maintenance requirements and versatile design possibilities, small rock gardens have become a beloved choice for homeowners and gardening enthusiasts alike.
In this article, we explore the Art of crafting these captivating vignettes, providing you with 20 low maintenance small rock garden ideas to transform your outdoor spaces into tranquil retreats.
Table of Contents
How do you Make a Simple Rock Garden?
Creating a simple rock garden is an exercise in thoughtful design and strategic planning. Begin by selecting a suitable location that receives ample sunlight and offers well-draining soil. Prepare the area by removing any existing vegetation and leveling the ground.
Next, strategically place larger boulders or rocks to establish the foundation and create a natural flow. Incorporate smaller rocks and pebbles to fill in the gaps, creating a visually striking tapestry of textures and shapes.
What do you put in a Rock Garden?
The beauty of rock gardens lies in their ability to showcase a diverse array of plants that thrive in rugged conditions. Succulents, alpines, and drought-tolerant perennials are excellent choices, as they require minimal water and maintenance.
Incorporate groundcovers, mosses, and dwarf conifers to add lush accents and create a sense of depth. Remember, less is often more in a rock garden, so choose your plants wisely and allow their unique forms and textures to take center stage.
How can I make my Rock Garden look Nice?
Elevating the aesthetic appeal of your rock garden is an art form in itself. Embrace the principles of contrast and balance by juxtaposing smooth and jagged surfaces, combining different shades of rocks, and incorporating natural elements like driftwood or water features.
Pay close attention to the placement of each element, creating focal points and guiding the eye through the composition. Incorporate decorative accents like boulders, sculptures, or even strategically placed lighting to add depth and dimension to your miniature landscape.
How do you Arrange Rocks in a Rock Garden?
Arranging rocks in a rock garden is a delicate dance between artistry and functionality. Begin by positioning larger boulders as anchors, establishing a sense of structure and stability. Smaller rocks can then be carefully placed to create visual interest and define pathways or planting areas.
Consider the principles of balance and asymmetry, avoiding overly symmetrical patterns that can appear contrived. Experiment with different configurations until you achieve a harmonious flow that feels natural and effortless.
20 Low Maintenance Small Rock Garden Ideas
1. Zen Oasis:
Embrace the serenity of a Japanese rock garden with meticulously raked gravel, strategically placed stones, and a tranquil water feature.
2. Desert Dreamscape:
Celebrate the rugged beauty of the desert with a tapestry of succulents, cacti, and sun-baked rocks, creating a vibrant and water-wise retreat.
3. Alpine Meadow:
Transport yourself to the serene alpine meadows with a rock garden adorned with hardy perennials, mossy boulders, and cascading waterfalls.
4. Coastal Charm:
Capture the essence of the seaside with a rock garden featuring driftwood, sea glass, and salt-tolerant plants, evoking the soothing rhythms of the ocean.
You May Also Like: GABION WALL IDEAS and LANDSCAPING GRAVEL TYPES
5. Fairy’s Grotto:
Craft an enchanting sanctuary for whimsy with miniature plants, moss-covered rocks, and a babbling brook, inviting the imagination to take flight.
6. Succulent Tapestry:
Celebrate the diverse forms and textures of succulents by creating a vibrant tapestry of echeverias, sedums, and sempervivums against a backdrop of smooth river rocks.
7. Woodland Wonder:
Recreate the serene ambiance of a forest floor with a rock garden featuring ferns, mosses, and strategically placed boulders, creating a cool and verdant oasis.
8. Minimalist Haven:
Embrace the beauty of simplicity with a rock garden featuring clean lines, carefully arranged rocks, and a limited palette of drought-tolerant plants.
Similar Info for You: FLOWER BED IDEAS and OUTDOOR KITCHEN IDEAS
9. Rustic Charm:
Incorporate weathered driftwood, rough-hewn boulders, and native grasses to create a rustic rock garden that exudes a sense of natural elegance.
10. Terraced Tiers:
Elevate your rock garden by creating terraced levels, each showcasing a unique combination of plants and rocks, adding depth and visual interest to your design.
11. Crevice Garden:
Mimic the natural habitat of alpine plants by creating a crevice garden, tucking delicate blooms and hardy succulents into the nooks and crannies between strategically placed rocks.
12. Desert Oasis:
Transform a sunny corner of your garden into a desert oasis, featuring a rock-lined water feature surrounded by drought-tolerant plants and sculptural cacti.
Fascinating Tidbits: SUSTAINABLE GARDEN IDEAS and VEGGIE GARDEN IDEAS
13. Sunken Serenity:
Embrace the tranquility of a sunken rock garden, where carefully placed boulders and cascading groundcovers create a secluded and intimate retreat.
14. Meditative Maze:
Craft a meditative rock garden maze, with winding pathways defined by strategically placed rocks and low-growing plants, inviting mindful wandering and reflection.
15. Zen Sculpture:
Incorporate a striking sculptural element, such as a large boulder or a carefully balanced rock formation, to create a focal point and add a sense of contemplation to your rock garden.
16. Tropical Fusion:
Blend the rugged beauty of rocks with the lush foliage of tropical plants, creating a vibrant and exotic rock garden that transports you to far-flung destinations.
More Intriguing Info: BACKYARD GAMES IDEAS and ROSE GARDEN IDEAS
17. Mosaic Masterpiece:
Incorporate colorful tiles, pebbles, or broken pottery pieces into your rock garden design, creating a stunning mosaic that adds depth and visual interest to your miniature landscape.
18. Riverbed Reverie:
Evoke the serene ambiance of a meandering riverbed by incorporating smooth river rocks, strategically placed boulders, and water-loving plants that thrive in moist conditions.
19. Dry Stream Bed:
Create a dry stream bed feature in your rock garden, using a combination of rocks and gravel to mimic the natural flow of water, adding movement and texture to your design.
20. Rockery Retreat:
Transform a sloped or elevated area into a rockery, carefully arranging boulders and planting drought-tolerant groundcovers to create a visually striking and low-maintenance retreat.
Read More: BACKYARD DECK IDEAS ON A BUDGET
Q: What is the best soil mix for a rock garden?
A: A well-draining soil mix consisting of equal parts topsoil, coarse sand, and small gravel is ideal.
Q: How much sunlight do rock garden plants require?
A: Most rock garden plants thrive in full sun, requiring at least six hours of direct sunlight daily.
Q: How do I prevent weeds from invading my rock garden?
A: Use a thick layer of gravel or landscaping fabric to suppress weed growth and maintain a neat appearance.
Q: Can I include water features in a small rock garden?
A: Yes, small water features like recirculating fountains or shallow basins add visual interest and a soothing ambiance.
Q: How often should I water my rock garden plants?
A: Water deeply but infrequently, allowing the soil to dry out between waterings to prevent root rot.
Indulge in the beauty of these low maintenance small rock garden ideas, and revel in the freedom they offer. No longer bound by the demands of traditional gardening, you can create a stunning outdoor retreat that harmoniously blends nature’s splendor with your personal style, all while enjoying the luxury of low maintenance.
Unleash your inner artist and let these captivating vignettes inspire you to craft a sanctuary of peace, one rock at a time.
Read Next: PRIVACY LANDSCAPING IDEAS

domain: artistic


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These hand-made stained glass decor pieces are beautiful and add a bit of sparkle to your home. The mobile is assembled with a nylon string and comes with a gold loop to hang it. They come in multiple colour variations!
Mercado General supports Canadian vendors, makers and products as much as possible, helping you treat yourself and your loved ones with the perfect gifts. By purchasing this product, you're supporting Stephanie from La Vie En Verre, a Edmundston NB based artist that creates beautiful stained glass when placed in a window always makes the world seem more magical and more peaceful.
Ships from our Bathurst, New-Brunswick-based shop within 3 business days. See here for our Shipping & Returns Policy.


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For at least a year, probably longer, I have wanted to do a session at a fair. The colors, the lights, the weather.....what's not to love about a county fair?!? We tried to do this last year, but got rained out, so I was super excited when Mabree & Conlee's mom was up for a redo this year! :) First off, these girls.....I mean, seriously??? Can you get any more gorgeous?!? They were perfect and I think had some fun too. :) I know I certainly enjoyed it. As you can tell, I had a little trouble narrowing down my favorites, and I played around with the editing a little more than usual. Enjoy some of my favorites!! Let me know which ones are yours! :)
September 20, 2012
September 12, 2012
I work with this handsome boys' mom. You probably remember them from several previous posts. I mean, how can you forget these beautiful faces?!? :) I got to borrow them this afternoon for a few candy store shots. They did so good, and we had lots of fun! Plus they got paid with a giant lollipop! :) Enjoy a few of my favorites!!!
September 5, 2012
I always always have fun shooting Hallee and her parents! They are so much fun, and are always up for any crazy ideas I have, and sometimes they have crazy ideas of their own. :) Hallee's 1 year shoot was a blast, and she did so good for me! Despite the horrible heat!! Enjoy! I had a hard time narrowing it down, as you can tell. :)


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|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|1368529||981701||2016||3 صفحه PDF||سفارش دهید||دانلود کنید|
Analogues of [Dmt1]DALDA (H-Dmt-d-Arg-Phe-Lys-NH2; Dmt = 2′,6′-dimethyltyrosine), a potent μ opioid agonist peptide with mitochondria-targeted antioxidant activity were prepared by replacing Dmt with various 2′,6′-dialkylated Tyr analogues, including 2′,4′,6′-trimethyltyrosine (Tmt), 2′-ethyl-6′-methyltyrosine (Emt), 2′-isopropyl-6′-methyltyrosine (Imt) and 2′,6′-diethyltyrosine (Det). All compounds were selective μ opioid agonists and the Tmt1-, Emt1 and Det1-analogues showed subnanomolar μ opioid receptor binding affinities. The Tmt1- and Emt1-analogues showed improved antioxidant activity compared to the Dmt1-parent peptide in the DPPH radical-scavenging capacity assay, and thus are of interest as drug candidates for neuropathic pain treatment.
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Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 15, 1 August 2016, Pages 3629–3631


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Hospital costs for treating newborns in opioid withdrawal jumped to $572.7 million
(CNN) -- The cost of treatment for infants in US hospitals who had been exposed to opioids rose by more than $250 million over four years, according to a study published Monday.
In 2012, total hospital costs to treat neonatal abstinence syndrome were $316 million. By 2016, according to the study published in the Journal of the America Medical Association Pediatrics, that number was up to $572.7 million.
Neonatal abstinence syndrome, known as NAS, occurs primarily in infants who were exposed to opioids while in utero. Newborns with NAS were hospitalized an average of 15.9 days, costing an average $22,550 per infant in 2016, the study said.
"In 2016, Medicaid was responsible for 83% of charges for in-hospital births with an NAS diagnosis, indicating that state and federal budgets may continue to bear disproportionate costs as the opioid crisis evolves," according to the study.
The rate of NAS births has risen significantly.
The rate of NAS soared from 1.5 in every 1,000 hospital births in 2004 to 8 in every 1,000 in 2014. In 2016, there were 6.7 cases of NAS for every 1,000 hospital births, the study said.
Opioid use during pregnancy has been linked to maternal mortality and risk of overdose for the mother, according to the CDC, while infants risk preterm birth, low birthweight, breathing problems and feeding problems.
An estimated 10.3 million Americans aged 12 and older misused opioids in 2018, including 9.9 million prescription pain reliever abusers and 808,000 heroin users. More than 130 people died every day from opioid-related drug overdoses in 2016 and 2017, according to the US Department of Health & Human Services.
™ & © 2019 Cable News Network, Inc., a WarnerMedia Company. All rights reserved.


When it comes to quality 3D printing used within dental labs, jewelry manufacturers and other important business/manufacturing settings, FDM/FFF technology can not be relied upon. This is simply because the resolutions required for these applications far surpasses those which are available on the market today using these technologies. In most cases, dentists, jewelry designers and manufacturers rely on stereolithography (SLA) 3D printers. With that said, even these machines vary greatly when it comes to resolution, print quality, and print speed.
One company who has been at the forefront of such technology, although they may not have the name recognition of a company like Formlabs, is Asiga. The company, which first launched their FreeForm 3D printer way back in November of 2011, has come forth with what they claim to be an even more incredible device, the Freeform Pico 2.
The Freeform Pico 2 machine uses special UV-LEDs in order to cure a photosensitive resin, a process based on their proven Slide-And-Separate (SAS) technology, allowing for minimal supports with optimal print speeds. The SAS technology is able to achieve the lowest fabrication forces of any upside-down SLA system, according to the company. Before we get into some of the capabilities, let’s take a brief look at the Pico 2’s general specifications:
- Printer Size: 460 x 560 x 500mm
- Printer Weight: 14kg
- Build Envelope: 51.2 x 32 x 75mm
- Pixel Size: 40 micron
- Print Speed: 40mm/hour
- Z-Resolution: Variable in 1 micron increments
- Material Compatibility: Any basic resins available on the market
As you can see by the size of the build envelope, this is not a 3D printer you want to put in your home or office to fabricate large items. It’s a professional machine targeted towards smaller items such as dental molds, crowns and bridges, or jewelry castings and manufacturing. The touch screen interface makes the Pico 2 simple to use, along with its single point calibration system which will allow for calibration in under 30 seconds.
The integrated Composer Build Gen software is incredibly intuitive, allowing for the streamlining of work flow, saving time by automatically generating supports for a print. The printer which has been unveiled this week at Euromold in Frankfurt, Germany has received quite a reception according to those at the show.
The printer package, which includes a calibration toolkit, the Pico Flash post curing device, and a material pack of your choice, certainly isn’t cheap, but for the quality, the $11,250 price tag may be worth it, especially for dentists and jewelry designers looking for the high resolutions required for their work.
Let us know if you have used any of Asiga’s 3D printers. Discuss in the Asiga Pico 2 3D Printer forum thread on 3DPB.com.
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There exist far more known causes of acquired hyperco-agulable disorders than inherited disorders. Additionally, several of the congenital hypercoagulable states may be seen as acquired states due to a change in the production or consumption of various factors. Many of the common causes of acquired hypercoagulable disorders will be discussed.
Heparin-induced Thrombocytopenia (HIT) and Heparin-induced Thrombocytopenia and Thrombosis Syndrome (HITTS)
Approximately 2 to 3% of patients who undergo heparin therapy will develop HIT or HITTS. Patients with HIT will have thrombocytopenia (characterized by a platelet count less than 100,000/mm3 or a decrease in the baseline count by more than 30%), will be resistant to anticoagulation with heparin, and may develop arterial or venous thromboses.
Two types of HIT exist. The first type is not associated with an immune mediated response and typically is seen in the first few days after initiation of heparin therapy. Typically, platelet levels do not fall below 100,000/mm3. Type II is immune-mediated with patients producing IgG antibodies against complexes of heparin and platelet factor 4. Antibody formation usually occurs between the fifth and tenth day after the first heparin exposure. The formation of these immune complexes creates a hypercoagulable state by activating platelets and the endothelium.8,20
Antibodies may develop against any form of heparin and the formation of antibodies is independent of the age or sex of the patient, the route of administration of heparin, or the amount of heparin administered. Clinically, a patient will have a declining platelet count, may have an increasing resistance to anticoagulation therapy with heparin, and may develop a new thrombosis. Laboratory testing may be performed, which includes testing for antibodies to heparin.1 Functional assays to detect platelet aggregation or activation in the presence of heparin-associated antibodies are well established. Enzyme-linked immunosorbent assays (ELISA) are readily available, but there is up to 40% discordance in the results of these antigenic assays, when compared with the functional platelet aggregation tests. The ELISA may detect IgM and IgA varieties, whereas platelet aggregation assays detect only the IgG antibodies.
The treatment of HIT includes the prompt discontinuation of heparin or low-molecular-weight heparin, and the administration of alternative anticoagulants such as recombinant hirudin or argatroban (both direct thrombin inhibitors). Danaparoid (a low-molecular-weight heparinoid) has been used in the past as an alternative anticoagulant in patients with HIT. However, danaparoid production was discontinued in 2002 due to a shortage in the drug substance. Fondaparinux (a pentasaccharide that inactivates factor Xa via an antithrombin-dependent mechanism) has had recent success as another alternative anticoagulant. As with hirudin and argatroban, there are no reliable agents that can reverse the anticoagulant effect of fondaparinux. Hirudin and fondaparinux are metabolized primarily via renal excretion, whereas argatroban is metabolized primarily by the liver.
Patients with heparin-induced thrombocytopenia are at high risk for the development of subsequent thromboses, and the discontinuation of heparin alone is usually not sufficient. Warfarin may be used for prolonged anticoagulation in patients with acute thromboses, but its initiation should be delayed until the platelet count has substantially recovered. In addition, warfarin therapy should overlap with the administration of a direct thrombin inhibitor until the platelet count normalizes.
Lupus Anticoagulant/Antiphospholipid Antibody Syndrome
The term antiphospholipid syndrome was developed to describe the clinical manifestations of a hypercoagulable state associated with antiphospholipid antibodies. The most commonly identified antiphospholipid antibodies are lupus anticoagulant, anti-cardiolipin antibody, and anti-P2-glycoprotein I antibodies.21
This syndrome is divided into primary and secondary syndromes. The primary syndrome occurs in patients without associated autoimmune disorders and the secondary syndromes occur in patients with systemic lupus erythematosus and/or other autoimmune disorders. The procoagulant effects of the antiphospholipid antibodies leading to thrombosis include inhibition of the activated protein C pathway, inhibition of antithrombin activity, inhibition of anticoagulant activity of P2-glycoprotein I, inhibition of fibrinolysis, potentiation of platelet activation, and enhanced platelet activation, among others.8,21
Antiphospholipid antibodies are found in 1 to 5% of the population and their prevalence increases with age. Among patients with SLE, the prevalence of antiphospholipid antibodies is much higher, with 12 to 30% having anticardio-lipin antibodies and 15 to 34% having lupus anticoagulant
TABLE 38.3 Criteria for the Classification of the Antiphospholipid Syndrome22
International consensus statement on preliminary criteria for the classification of the antiphospholipid syndrome
Vascular thrombosis: 1 or more clinical episodes of arterial, venous, or small vessel thrombosis, occurring within any tissue or organ.
Complications of Pregnancy:
1 or more unexplained deaths of morphologically normal fetuses at or after the 10th week of gestation; or
1 or more premature births of morphologically normal neonates at or before the 34th week of gestation; or
3 or more unexplained consecutive spontaneous abortions before the 10th week of gestation.
Anticardiolipin IgG or IgM antibodies present at moderate or high levels in the blood on 2 or more occasions at least 6 weeks apart.
Lupus anticoagulant antibodies
Lupus anticoagulant antibodies detected in the blood on two or more occasions at least six weeks apart.
antibodies. In patients with SLE and an antiphospholipid antibody, 50 to 70% may develop the antiphospholipid syndrome.1 In order for the diagnosis of antiphospholipid syndrome to be made, the patient must meet the criteria of the International Consensus Statement. A definitive diagnosis may be made if the patient has at least one of the clinical criteria and one of the laboratory criteria. The Consensus Statement is defined in Table 38.3.
Clinically, the most common manifestation of the antiphospholipid syndrome is deep venous thrombosis of the legs. Arterial thrombosis also may be seen but less often than venous thrombosis. Laboratory tests to detect the antiphos-pholipid antibodies include the activated partial thrombo-plastin time (aPTT), performed with and without exogenous normal plasma to detect the presence of an inhibitor. Other tests include the kaolin clotting time, and dilute Russell's viper venom time (dRVVT). ELISA tests are performed to detect anticardiolipin antibodies and anti-P2-glycoprotein I antibodies.21
Aspirin and hydroxychloroquine have been used in subsets of patients with the antiphospholipid syndrome for prophylaxis against thrombotic events. The treatment of established venous thromboembolism in these patients consists of acute heparinization and longer-term (possibly life long) vitamin K antagonists. The optimal intensity of warfarin anticoagulation (INR 2.0-2.9 versus 3.0-3.9) has not been determined.21
This disorder is the most severe nonhemorrhagic complication of oral anticoagulation. Although rare, it seems to show a predilection for perimenopausal obese women who are being anticoagulated. Venules and capillaries within the subcutaneous fat and overlying skin thrombose, leading to necrosis. This typically is seen in the subcutaneous fat of the breasts, thighs, buttocks, and legs. Clinically, the patient may initially have paresthesias, which are then followed by painful, erythematous lesions. When hemorrhagic bullae are present, this is indicative of full thickness skin necrosis.
The pathogenesis for this process is the depletion of protein C prior to the other vitamin K-dependent coagulation factors. As the half-life of protein C is only eight hours, its rapid depletion causes a transient hypercoagulable state until the rest of the vitamin K-dependent factors also are reduced to levels that produce anticoagulation.
The primary treatment is prevention with heparin or low-molecular-weight heparin anticoagulation for the first 48 to 72 hours of anticoagulation with warfarin. If skin necrosis develops, warfarin needs to be discontinued and anticoagulation may continue with heparin or a direct thrombin inhibitor.8
The risk of thrombosis is dependent on the type of surgery and the presence of additional risk factors. This risk may persist for up to several months after surgery. Patients who are at particularly high risk include those who undergo hip fracture surgery, hip or knee arthroplasty, neurosurgical procedures, and patients with major trauma. Injury to tissues and vessels during the procedure may enhance thrombogen-esis.8,23 Operative dissection, thermal injuries, and soft tissue trauma activate the coagulation cascade by inducing tissue factor release, thereby increasing the thrombogenic risk.
With a major traumatic injury, risk for venous thrombosis is highest in patients with spinal injuries, pelvic fractures, and lower extremity fractures. The risk of thrombosis also increases with greater injury severity. In part, this may be due to the accompanying systemic inflammatory response (another prothrombotic state, covered later).
During pregnancy, there is an associated hypercoagulable state due to the increase in factors I, VII, VIII, IX, X, XI, and XII. Additionally, platelet counts increase and concentrations of protein S and antithrombin decrease. The fibrino-lytic system also may be inhibited secondary to the increased production of plasminogen-activated inhibitors 1 and 2 by the placenta. Compounding this risk is the degree of stasis that occurs as a result of compression of the lower extremity veins by the gravid uterus. In the postpartum period, the risk for thrombosis is up to five times greater than during pregnancy. Approximately two months after delivery, the coagulation and fibrinolytic systems will return to normal.1
The risk of thrombosis is increased further in pregnant women who have a genetic risk for thrombosis. Depending on the inherited thrombophilia, a woman with a thrombo-philia who becomes pregnant may have a risk of venous thrombosis up to eight times higher than those without a thrombophilia.4 In addition, women with a genetic risk for thrombosis are also at an increased risk for fetal loss and pre-eclampsia. Many women with a history of thrombo-philia or thromboembolism are treated with heparin, low-molecular-weight heparin, and/or aspirin while pregnant.24
Oral contraceptives are one of the most frequently used drugs by women. The use of oral contraceptives initially was associated with a three-fold increased risk of venous thrombosis. With the decrease in the amount of estrogen placed in the pill, a subsequent decrease in the incidence of venous thrombosis was seen. With lower levels of estrogen, the risk of thrombosis is 1.5 to 2 times that over control patients. Additionally, newer oral contraceptives using newer progesterones have shown an increased risk of thromboembolism.25
The risk for venous thrombosis is highest during the first year of use of the oral contraceptive and the risk is not cumulative with prolonged use. Once the pill is discontinued, the risk returns to baseline for that patient.25,26
Oral contraceptives influence the plasma levels of nearly every protein involved in coagulation. Factors VII, VIII, IX, X, and XI increase, and the natural anticoagulants anti-thrombin and protein S decrease. However, oral contraceptive administration is associated with elevated protein C, ^-antitrypsin, and fibrinolytic proteins, producing an anti-thrombotic effect. Additionally, the pill has been associated with an acquired activated protein C resistance occurring within three days of initiation of the pill and reversing with discontinuation. This resistance has been shown to have a more pronounced increase in those women using third-generation oral contraceptives. The combination of activated protein C resistance, increased prothrombin levels, and decreased protein S levels produces a net pro-thrombotic affect and confers the prothrombotic risk of oral contraceptives.27,28
In women with inherited thrombophilias who also take oral contraceptives, the risk for thrombosis increases 30- to 50-fold. For example, women who take oral contraceptives and are heterozygous for the Factor V Leiden mutation have been shown to have an increased risk of venous thrombosis by a factor of approximately 35. This increased relative risk for venous thrombosis is in the same order of magnitude as patients who are homozygous for the Factor V Leiden mutation (almost 50-fold increased risk). The women who have other inherited thrombophilias also appear to have a remarkably increased risk.4,25
Historically, hormone replacement therapy (HRT) has been used to reduce the progression of osteoporosis, relieve the symptoms of menopause, and reduce the cardiovascular risk profile. Several studies including the Heart Estrogen/ Progestin Replacement Study (HERS) and the Women's Health Initiative (WHI) have shown an increased risk of venous thromboembolism with the use of HRT. A two- to four-fold increased risk, compared to nonusers, has been shown.26,29
Similar to oral contraceptives, the risk of venous throm-boembolism is highest during the first year of HRT. Once HRT is discontinued, the risk of thrombosis returns to baseline. Additionally, increasing age has been associated with an increased risk of venous thrombosis. Several studies also have shown an increased risk in patients using HRT who had lower extremity fractures, recent surgery, previous venous thromboembolism, cancer, and obesity.29 Also similar to oral contraceptive pills, patients on HRT with thrombophilias have a significantly increased risk of venous thromboembo-lism.4 The coagulation factor changes, which occurs as a result of hormone replacement therapy, and is similar to those changes that occur with oral contraceptive pills, but to a lesser degree.
Systemic Inflammatory Response (SIR) and Sepsis
With the systemic inflammatory response, cytokines and other inflammatory mediators are released causing a pro-thrombotic state. Specifically, tumor necrosis factor a and interleukin-1a are increased. These factors activate the coagulation cascade, cause an increase in tissue factor expression, and decrease levels of protein C and S. Fibrino-gen synthesis also will increase as part of the inflammatory response. Additionally, the inflammatory response is enhanced by thrombin, which augments leukocyte adhesion and activates platelets. Platelet activation in turn, further promotes tissue factor expression and increases cytokine release. All these factors contribute to the hypercoagulable state seen with SIRS and sepsis and predispose the patient to thrombosis.30
Venous thromboembolism (VTE) is a common complication of cancer. In 10% of patients who present with an idiopathic VTE, malignancy will be discovered. The majority of thrombotic episodes occur spontaneously, although patients with cancer often have other concurrent risk factors (inherited thrombophilias, immobilization, major surgical proce dures, chemotherapy, and central venous catheters) that place them at high risk for venous thromboembolism.
Tissue factor and cancer procoagulant are produced by tumor cells. The cancer procoagulant directly activates factor X independently of factor VII. Additionally, tumor cells produce proteins that may regulate the fibrinolytic system. These proteins impair fibrinolytic activity leading to a prothrombotic state.31 Tumor cells also produce various cytokines and affect the coagulation cascade and induce a thrombogenic state in a similar manner as SIRS. TNF-a and interleukin ip are released by cancer cells and induce tissue factor expression and down-regulate thrombomodulin. Furthermore, tumor cells activate other cytokines and several different types of leukocytes, which also increase tissue factor expression and activate platelets. The interaction of all these processes lead to a prothombotic condition.31
We perform testing for inherited thrombophilic conditions in the following clinical circumstances: idiopathic DVT, recurrent DVT, DVT with young age at onset, and venous thromboses in unusual locations (mesenteric or portal venous thrombosis, cerebral vein thrombosis). Many hospitals provide testing with a "hypercoagulable panel." However, the clinician should ascertain that the following tests are being performed: antithrombin activity, protein C activity, protein S activity, testing for either activated protein C resistance or factor V Leiden, prothrombin gene mutation, homocysteine levels, anticardiolipin antibody and lupus anticoagulant testing, factor VIII activity. Antithrombin, protein C, and protein S levels may be depressed by the presence of acute thrombosis. Protein C and S may be similarly affected by warfarin administration. Therefore, an abnormal test result drawn during these time periods does not necessarily signify the presence of an inherited throm-bophilic condition. Repeat testing is required.
Other Acquired Hypercoagulable Conditions and Treatment Stratification
Patients are predisposed to thrombosis via many other clinical conditions. These conditions may affect the coagulation cascade, the fibrinolytic system, and/or platelet function, thereby increasing the risk of thrombosis. With two or more conditions that predispose to thrombosis, the patient is at a higher risk for suffering a thrombosis.
The objectives for treating acute venous thromboembolism include the prevention of death from pulmonary embolism, reduction of lower extremity symptoms, prevention of the post-phlebitic syndrome, and prevention of recurrent venous thromboembolism. By limiting the propagation of
TABLE 38.4 American College of Chest Physicians Recommendations for Duration of Anticoagulation for Venous Thromboembolism32
First episode DVT/transient risk
First episode DVT/concurrent cancer
First episode DVT/thrombophilia antithrombin deficiency protein C and S deficiency factor V leiden prothrombin 20210 homocysteinemia factor VIII elevation (>90th %)
First episode DVT/thrombophilia Antiphospholipid antibodies 2 or more thrombophilias
UH/LMWH followed by 3 mos
VKA 3-6 mos LMWH Indefinite anticoagulation until cancer resolves UH/LMWH followed by 6-12 mos
VKA (suggest indefinite) UH or LMWH followed by 6-12 mos VKA (suggest indefinite if idiopathic)
UH or LMWH followed by 12 mos VKA (suggest indefinite)
UH or LMWH followed by indefinite VKA
UH = unfractionated heparin, LMWH = low-molecular-weight heparin, VKA = vitamin K antagonist.
thrombus, anticoagulation potentially has a role in achieving all of these objectives. Initial anticoagulation with unfrac-tionated heparin or low-molecular-weight heparin, followed by six weeks to six months of oral vitamin K antagonists has been the mainstay of therapy. More recently, the American College of Chest Physicians Consensus Statement has stratified the type and duration of anticoagulation, based in part on the whether the patient has a concurrent thrombo-philic condition (see Table 38.4).32 In general, the overall trend is to extend the duration of anticoagulation, especially in patients with recurrent DVT, antiphospholipid syndrome, and patients with multiple thrombophilic conditions. In patients with malignancy and venous thromboembolism, the recommended duration of low-molecular-weight heparin therapy has been extended to three to six months, followed by long-term vitamin K antagonists.
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domain: biology


Hot! We’ve recently came across a lone spyshot of what could possibly be the upcoming 2016 Proton Saga!
Judging from the clearest rear end shot we shown here, much of the design elements are present on this white sedan, including the elongated tail lights plus the centre-mounted rear foglight. From the shot above, it appears that at least one variant of the Saga will feature a large chrome strip that cuts across the tailgate. Much like the 2016 Proton Perdana, the Saga’s chrome strip integrates nicely into the tail lights.
The upcoming Proton Saga, when it debuts later this year, will go head-to-head against the all-new Perodua Bezza. The Proton Saga is said to receive a 1.3-litre Campro VVT engine, mated to a CVT or Getrag five-speed manual. In fact, the Saga could be fitted with VSA, TC and Hill Hold Assist, on top of ABS, EBD and BA.
Stay tuned for more details!
Photo credit: Proton Saga 2016 Community on Facebook


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Description of the Accommodation
Rooms, services O Hotel Los Angeles would be glad to host you for a memorable journey in Los Angeles. The hotel is offering a tastefully furnished room to those seeking accommodation in Los Angeles. If you feel like having a meal not included in your chosen type of catering, you can always taste local dishes in the restaurant of the hotel. Nearby boat rental opportunities will provide an excellent chance to spend your leisure time actively. The bar has excellent atmosphere for a relaxed evening talk or a personal meeting. The exact list of services available at O Hotel Los Angeles (including those for an extra fee) and the exact list of equipment in a room can be found on the information sheet below.
Arrival, opening hours The personnel can speak English.
O Hotel Los Angeles rooms Rooms
Boat rental nearby


Lenovo Thinkpad T420 - Intel Core i5 2520M 8GB 320GB Windows Professional (Renewed)
$299.77 in stock
1 new from $299.77
as of March 24, 2020 13:35
- Lenovo ThinkPad T420 Laptop PC, Intel Core I5 2520M up to 3.2GHz, 8G DDR3, 320G SSD.
- Port: Display Port, 34mm Express Card slot and SD Card reader, 1 Always-On USB 2.0 with yellow marking, 2 USB 2.0, 1 USB 2.0/Esata Combo 4 in 1 Card Reader
- Operating System: Windows 10 Home 64 Bit – Multi-language supports English/Spanish/French.


The release of Chat GPT by Open AI has struck a nerve with just about everyone. Even Google is freaking out, going so far as bringing in their founders to review all of Google’s AI projects
Last month, Larry Page and Sergey Brin, Google’s founders, held several meetings with company executives. The topic: a rival’s new chatbot, a clever A.I. product that looked as if it could be the first notable threat in decades to Google’s $149 billion search business.
Mr. Page and Mr. Brin, who had not spent much time at Google since they left their daily roles with the company in 2019, reviewed Google’s artificial intelligence product strategy, according to two people with knowledge of the meetings who were not allowed to discuss them. They approved plans and pitched ideas to put more chatbot features into Google’s search engine. And they offered advice to company leaders, who have put A.I. front and center in their plans.
The re-engagement of Google’s founders, at the invitation of the company’s current chief executive, Sundar Pichai, emphasized the urgency felt among many Google executives about artificial intelligence and that chatbot, ChatGPT.NY Times
It is not just Google who are realizing how transformative and ‘cage rattling’ tools like Chat GPT. Universities and colleges all around the world are freaking out about how Chat GPT can spit out a well written dissertation about just about anything, raising alarm bells of how students could rely on such technology to help them get their homework done.
Even beyond text, AI is creating art, visuals and virtual worlds that just don’t exist. Check out this Instagram called The Visual Dome. None of it is real.
The irony is that people have been interacting with AI technology for years – think about how you have interacted with most big banks or other companies when you call their Customer Service systems. They have been using AI generated capabilities to handle a wide range of inquiries from people before ever reaching a human representative.
I’ve seen several articles cite technology and business leaders cite the time they first saw and interacted with distinctive and game changing technologies that have fundamentally altered the world – Netscape Navigator, and the iPhone being two of them – and they have all said that Chat GPT is another one of those game changers. The future is the present, folks.


Kia has revealed its new Stonic SUV, a B-segment compact crossover that will go on sale in the Autumn.
The B-SUV segment currently accounts for 1.1 million new car sales in Europe each year and is forecast to expand to more than two million annual sales by 2020.
“The Kia Stonic will be one of the most compelling new cars in this rapidly-expanding class, backed by Kia’s unique warranty, and the brand’s reputation for reliability, quality and contemporary design,” said Michael Cole, chief operating officer of Kia Motors Europe.
A range of petrol and diesel engines will be available, each paired with a manual transmission. The lowest emissions in the range will come from a 1.6-litre diesel unit
Kia says the car’s European-tuned steering and suspension have been designed to offer an exciting drive, with immediate handling responses and a stable ride.
Both the exterior and interior will benefit from a range of customisation options and colours, including a two-tone roof.
A touchscreen infotainment system will provide Apple CarPlay and Android Auto as standard. There will also be the option of heated front seats, cruise control and keyless entry.
Owners can choose from a selection of Kia’s DRiVE WISE Advanced Driver Assistance Systems (ADAS) to enhance active safety. These technologies include Autonomous Emergency Braking with pedestrian recognition and Forward Collision Alert; Blind Spot Detection with Rear Cross Traffic Alert; and Lane Departure Warning System.


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Early salary payment, bonus for Eid and greater competition in the funds transfer market have all resulted in a 15% increase in remittances from the Gulf .PTI 24 Jun 2014, 18:15
Remittances to India are expected to grow 8 per cent year-on-year to reach about USD 77 billion in 2014, Xpress Money's VP Sudhesh Giriyan said today.ECONOMICTIMES.COM 23 Jun 2014, 19:06
According to World Bank figures, with inward remittances touching $ 70 bn in 2013 alone, India is the largest recipient of international remittances.PTI 13 Jun 2014, 13:33
India has been at the forefront of inward remittances for several years now. Last year, the final figure announced by the World Bank and the RBI was $70 billion.PTI 11 Apr 2014, 23:31
In India, remittances during 2013 were $70 bn, more than the $65 bn earned from country's flagship software services exports, the World Bank said.26 Mar 2014, 16:46
States like Kerala, Maharashtra and Tamil Nadu contributed nearly 60 per cent of total inflows in the year, the company said in a statement.PTI 19 Feb 2014, 15:49
Vayalar Ravi told Lok Sabha today that there has been no decline in remittances from the approximately 25 million members of the Indian diaspora.PTI 9 Jan 2014, 12:25
Chandy said NRK's not only fetch money but also share their ideas and inspire the state to think in a world class manner.PTI 24 Dec 2013, 18:11
India Post has launched international money remittance service on the International Financial System (IFS) platform of Universal Post Union (UPU).PK Krishnakumar 21 Nov 2013, 12:34
Federal Bank has tied up with Muthoot Global Money Transfer in a rupee drawing arrangement for facilitating remittances in rupee from the UK.
The ministry, which has floated a tender for six cameras last month — each camera has 32 channels — has already received price quotes.
It's an effort to raise awareness of ALS where participants must dump a bucket of ice cold water and then dare someone to do the same.
Real homage to BKS Iyengar would be to use his teaching to separate the grain from the chaff in all that goes in the name of yoga.
Indian Railways - the lifeline of India - are set for a revamp, with multiple initiatives being taken to enhance passenger experience.
Startups set up by these under 22-year-olds (approximately the age at which students graduate from colleges) are working with new-age technology.
Small Unmanned Aerial Vehicles are making an impact across sectors and market. The market size for them is expected to reach $33.5 million by 2019.
Low fare carrier SpiceJet has said it crossed Jet Airways in market share figures to become India's number 2 carrier--a historical first--in July.
A Congress leader said the decision was taken after the leadership and some CMs felt “Modi is stage-managing humiliation of Congress CMs".
Some of India's biggest companies are pouring billions of dollars into manufacturing guns, ships and tanks for the country's military.
There are 11 categories, and within them 42 players, that are poised to shape Indian e-commerce's projected multi-billion dollar boom.
PM Narendra Modi had listed Digital India as among top priorities for his government, while delivering his maiden Independence Day speech.
The senior RBI official said developments in construction technologies should make it possible for developers to bring down home prices.

domain: news


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Salon littéraire: Le Dernier Jour d'un condamné et Claude Gueux de Victor Hugo
Date: 07 Oct 2023, 2:00pm - 3:00pm (GMT-08:00) Pacific Time (US & Canada)
SATURDAY, October 7
2PM - 3PM
SUITE 204 (LIBRARY)
Join us at the AFSeattle Library for our traditional Salon littéraire. This time, we will go back to our classics and
discover two short stories by Victor Hugo, Le Dernier Jour d'un condamné and Claude Gueux.
As a reminder, the discussion is recommended for French speakers at level A2+ (upper intermediate) or above. However, participants are
welcome to read the book in English if they prefer.
Free for AF members / $5 for non-member. Please RSVP below!
Le Dernier Jour d'un condamné is a novella recounting the thoughts of a man condemned to die. Victor Hugo wrote
it in1829 against the death penalty.
Claude Gueux is a short story first published in 1834 and
based on a true story.
We follow Claude Gueux,, a poor Parisian worker who is forced to steal in order to survive. He is caught and ends up in prison, where a
series of events lead him to commit a terrible crime, for which he is sentenced to death.
Both short stories are representative of Victor Hugo's social engagement and literary predilection subjects : education, criminal
justice and social misery.
Considered to be one of the greatest French writers of all time, Victor Hugo (1802-1885) is known for his Romantic
poetry and dramatic work and his engaged novels such as Notre-Dame (1831) and Les Misérables (1862).
He also served in politics as both deputy and senator.
His work touched upon most of the political and social issues and the artistic trends of his time, which established him as a
Victor Hugo died on 22 May 1885, aged 83. He was given a state funeral in the Panthéon of Paris, which
was attended by over 2 million people, the largest in French history.
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text:
A Tilehurst man who suffers from severe chronic back pain says an NHS organisation is refusing to fund the operation which could transform his life.
Austin Emery-Cox has been effectively housebound and unable to work since December 2016 as long-standing problems with four discs in his back have caused severe sciatica.
The 40-year-old, from Norfolk Road, who has been plied with painkillers and anti-inflammatories, has seen two of his GP's requests to fund a spinal fusion operation get rejected.
The South Reading Clinical Commissioning Group (CCG), which dealt with the requests, claims he has not allowed enough time for physiotherapy to take effect.
But the experienced massage therapist says that after numerous physio sessions, massages and consultations with an osteopath, his condition has not improved.
He insists that he "desperately" needs the procedure "to get me back into good health, allow me to return to work and also get my life back."
And after eight months of relying on statutory sick pay, he is now struggling to pay his rent and other bills, and says he cannot afford to get the procedure done privatley.
He said: "I was gobsmacked and mortified when the requests got rejected, how can they let me stay like this, when I'm on loads of drugs and I can't go back to work?
"I'm on five different drugs, which I have to take every two hours, nine times a day.
"I have pain management medication and anti-inflammatory medication which basically tear apart your insides, so I also have to have stomach medication.
"Now they have moved me on to opium packets and told me that this effectively makes me a drug addict, so they're going to have to spend three months weaning me off. This can't be good for my health.
"We have actually worked it out and the amount of money they are spending on all of these drugs, could be used to pay for my surgery."
Individual funding requests in Reading 2013-17
Mr Emery-Cox is one of hundreds of patients in Reading who have seen requests for medical producers get rejected in recent years.
The requests are made by clinicians on behalf of patients for treatments which are no longer routinely funded in particular areas.
"I just want someone to help me"
Mr Emery-Cox added: "I have 30 to 40 years left in me and if I get the help I need I could spend that time working and contributing to the economy, or I could just be a drain on the economy.
"I just want someone to help me so that I can get the necessary funding released for me to have an operation."
CCGs in Reading and across the country have seen a spike in IFRs since 2013 and BMJ chair Richard Vautrey says the cash-strapped organisations may be using them to "reduce referrals and costs".
There is no evidence that South Reading CCG, which is one of the lowest funded CCGs in the country, has deployed this tactic.
But a section outlining IFRs on an NHS website states: "there is only a set amount of money available to spend so difficult decisions may have to be made."
An NHS spokeswoman said: “With the patient’s consent, his concerns are currently being investigated as a formal complaint by NHS South Reading Clinical Commissioning Group, which will provide a response in due course.”Don't forget you can also keep up to date with the latest via the free getreading app. You can download it for Apple devices here and Android devices here.