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Prevalence of Extraglandular Manifestations in Patients With Primary Sjögren’s Syndrome in Southern Norway: A Comparison to the Literature
Lars JORKJEND1, Anders JOHANSSON2, Ann Katrin JOHANSSON3
1University of Oslo, Section of Dental Pharmacology and Pharmacotherapy, Oslo, Norway
2Department of Clinical Dentistry-Prosthodontics, University of Bergen, Faculty of Medicine and Dentistry, Bergen, Norway
3Department of Clinical Dentistry-Cariology, University of Bergen, Faculty of Medicine and Dentistry, Bergen, Norway
Keywords: Extraglandular manifestations, prevalence, Sjögren’s syndrome
Objectives: This study aims to investigate the prevalence of extraglandular manifestations (EGM) in a group of Norwegian patients suffering from primary Sjögren’s syndrome (pSS) and compare these findings with the literature.
Material and methods: Fifty-three female patients (mean age 60±11.6 years; range 33 to 85 years) fulfilling the clinical criteria for pSS were included in the study. To investigate the prevalence of EGM, a PubMed search from April 1976 to August 2012 identified 100 relevant publications by 88 authors, comprising a total of 14,861 pSS patients. An attempt was made to compare the obtained results regarding the prevalence of EGM with our results.
Results: In our study group, mean prevalence rate of EGM was 42.1% with a range from 0 to 92.5% compared to the range of 0.8 to 94% in the PubMed reports on EGM. Epidemiological studies involving large groups of patients tend to yield lower prevalence of EGM than studies based on a smaller sample size. We were unable to compare the reports of prevalence of EGM in patients with pSS due to different methodologies and classification criteria applied in the different studies.
Conclusion: The prevalence of pSS in this study was within the range of that reported in the literature. Due to methodological issues, we were unable to compare reports of prevalence of EGM in pSS. Our findings suggest that studies including larger sample sizes may be subjected to underreporting.
Sjögren’s syndrome (SS), an autoimmune exocrinopathy with unknown etiology, is considered to be one the most common systemic inflammatory connective tissue diseases. A prevalence ranging from 0.04 to 0.66% has been reported for primary Sjögren’s syndrome (pSS)(1,2) depending on the investigated populations and the classification criteria used. PSS affects particularly females in the fourth and fifth decades of life, with a female/male ratio of 9:1. The disease mainly affects the exocrine glands and usually presents itself as a persistent dryness of the mouth and eyes, resulting in functional impairment of the lacrimal and salivary glands due to lymphocytic infiltration and a subsequent loss of glandular tissue. Extraglandular organs may be complicated by the development of extraglandular involvement and organ-specific autoimmune disease.(3) As patients with pSS may have involvement of many organs beyond the exocrine glands, the clinical manifestation of pSS is divided as exocrine gland features and extraglandular manifestations (EGM),(4) the latter being experienced by a relatively high number of patients.(5-7) The development of other types of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus among patients with SS is also frequently observed.(8,9) In this study, we aimed to investigate the prevalence of EGM in a group of Norwegian patients suffering from pSS and compare these findings with the literature.
Patients and Methods
Fifty-three female patients (mean age 60±11.6 years; range 33 to 85 years) were included in the study. All of the patients fulfilled the clinical criteria for pSS(10) and data related to EGM was extracted from their journals, which was diagnosed on the basis of both subjective symptoms and objective signs, i.e. positive biopsies of minor labial salivary glands and pathological unstimulated salivary flow (≤0.1 mL/min).
To investigate the prevalence of EGM, a PubMed search from April 1976 to August 2012 identified 100 relevant publications by 88 authors, comprising a total of 14,861 pSS patients. An attempt was made to compare the obtained results regarding the prevalence of EGM with our results.
Mean prevalence rate of EGM was 42.1%. In addition to EGM, the following symptoms were observed: osteoporosis (3.4%), allergy (30.3%), swollen glandules (34.8%), swollen parotid gland (23.6%), chilling (65.2%), and diabetes mellitus (6.7%).
Data from our study and the studies in PubMed on EGM and the frequencies of EGM in patients with pSS are shown in Table 1. While the prevalence range of EGM in PubMed reports was 0.8 to 94%, the range in our study was 0 to 92.5%. We were unable to compare the reports of prevalence of EGM in patients with pSS due to different methodologies and classification criteria applied in the different studies.
There was a significant negative correlation between the number of participants in the PubMed studies and the frequency of EGM (Spearman’s correlation coefficient =-0.42; p<0.001) (Figure 1).
Clinimetrics, tools for assessing or describing symptoms, signs, and laboratory findings by means of scales, indices, and other quantitative instruments were not consistently used in the reviewed publications in PubMed on SS and EGM. The abundance of different measurement instruments in specific fields hampers the comparison of study results, and clinimetric properties are population and situation dependent.(11) In diagnosing pSS, there are defined indices(12) and scales for EGM.(13) Other types of EGM are usually diagnosed on the basis of both subjective symptoms and objective signs. Quantitative assessment of both clinical disease activity and organ damage in SS patients has been proposed.(14,15) Also, a damage index and disease activity index, i.e. scoring systems for the assessment of disease damage and disease activity in SS patients were proposed.(15,16) There is a need for validated indexes that evaluate disease reversible activity and permanent damage.(13)
There is no agreement concerning the sets of classification criteria for SS.(17) When the San Diego criteria are used, only 15% of patients fulfilling the European criteria for SS(10) will be diagnosed as SS - a fact that must be considered when evaluating reports on SS.(18) According to the classification criteria of the American-European Consensus Group,(19) the prevalence of pSS is far lower than previously assumed, and the reported male/female ratio of 1:9 seems to lie more in the range of 1:20.(20) Use of the American-European Consensus Group criteria will probably result in the participation of fewer males, as well as younger patients in general, and more severely ill patients in future cohort investigations.(21) Information regarding age at disease onset has changed over the last decade, as recent studies are indicating an onset age of approximately 45 years, compared to 56 in earlier studies.(21)
There is a limitation of studies on EGM in pSS in the completely healthy (asymptomatic) control groups of individuals: “It is not feasible to assemble sufficiently large, population- based control groups of completely healthy individuals”.(22) Variations detected by Sjögren’s International Collaborative Clinical Alliance Registry(22) in the actual populations, recruitment sources, investigation methods as well as the inclusion criteria and definitions regarding organ involvement utilized by the various investigators may, together with environmental factors, genetic, and race differences, be the causes for such differences. Furthermore, there is a relationship between the number of systemic autoantibodies and the number of EGM in pSS with a high prevalence of anti-Sjögren syndrome A antigen, anti-Sjögren syndrome B antigen, anti-nuclear antibodies, and immunoglobulin M-rheumatoid factor antibodies, indicating that a more disturbed immune system (as characterized by the presence of hypergammaglobulinemia and multiple autoantibodies formed by hyper-reactive B-cells) may result in more EGM.(23)
The number of patients in our clinical investigation may be limited to draw firm conclusions; however, our results support those reported in the literature. Similarly, 42 of the 100 publications in PubMed had 53 or fewer patients. The percentages of EGM in our study were generally higher compared to the percentages drawn from PubMed but still within the range of PubMed percentages (0.8 to 94%, Table 1). This difference may be due to the diagnostic criteria utilized, i.e. whether the diagnosis was based on the patients’ subjective report or on objective medical information. Also, the selection of patients may have been of importance.
In their study, Lin et al.(24) showed systemic detriment in as much as 91.4% of inpatients with pSS. This high percentage was explained by the application of more advanced methods for diagnosing early organ damage. Another explanation may be that this particular group of pSS patients were more severely ill, since hospitalized. Our patients came from a private dental clinic and symptoms/diagnoses were extracted from the patients’ journals in which diagnosis was made on the basis of both subjective symptoms and objective signs, which again may explain the diverging prevalence of EGM.
One unexpected finding has been that according to the PubMed search, studies with higher numbers of investigated patients resulted in decreased prevalence of EGM, as compared to studies with fewer number of patients (Figure 1). It is tempting to speculate that the reason for this lower prevalence in studies with more participants may be that the time allocated for individual examinations may have been shorter due to the high number of participants. The presumed time limitation might thus have resulted in less scrutiny. Another explanation may be that only findings based on objective medical investigations were used in those studies and not self-reports, which may underestimate the prevalence of some systemic disorders.(25) If so, this raises a question towards epidemiological studies based on a vast number of patients. That is, can a smaller group of examined patients raise the quality of the investigation? In our study where we had a relatively low number of participants with a relatively high number of reported EGM, it was possible to allocate ample time for completion of the questionnaire. Nevertheless, decreasing prevalence of EGM with increasing number of participants in epidemiological studies needs to be considered when evaluating the prevalence of EGM in pSS patients, which again calls for further investigation. In this study, our objective was to compare our results with the mean prevalence found in the PubMed investigation; however, based on the above discussion, it is difficult to make a reliable comparison of EGM prevalence rates.
In conclusion, our extensive review of 100 publications from Asia, Europe, Africa, and America shows that EGM in patients suffering from pSS is common. There was a significant range of prevalence in the PubMed reports on EGM. The use of different classification criteria and lack of control groups in some studies should be taken into consideration regarding the data from the studies included in this article. Also, it should be kept in mind that epidemiological studies involving large groups of patients tend to yield lower prevalence of EGM than studies based on a smaller sample size.
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
The authors received no financial support for the research and/or authorship of this article.
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- Pokorny G, Karácsony G, Lonovics J, Hudák J, Németh J, Varró V. Types of atrophic gastritis in patients with primary Sjögren’s syndrome. Ann Rheum Dis 1991;50:97-100.
- Grande L, Lacima G, Ros E, Font J, Pera C. Esophageal motor function in primary Sjögren’s syndrome. Am J Gastroenterol 1993;88:378-81.
- Ostuni PA, Germana B, Di Mario F, Rugge M, Plebani M, De Zambiasi P, et al. Gastric involvement in primary Sjögren’s syndrome. Clin Exp Rheumatol 1993;11:21-5.
- Collin P, Karvonen AL, Korpela M, Laippala P, Helin H. Gastritis classified in accordance with the Sydney system in patients with primary Sjögren’s syndrome. Scand J Gastroenterol 1997;32:108-11.
- Anselmino M, Zaninotto G, Costantini M, Ostuni P, Ianniello A, Boccú C, et al. Esophageal motor function in primary Sjögren’s syndrome: correlation with dysphagia and xerostomia. Dig Dis Sci 1997;42:113-8.
- El Miedany YM, Baddour M, Ahmed I, Fahmy H. Sjogren’s syndrome: concomitant H. pylori infection and possible correlation with clinical parameters. Joint Bone Spine 2005;72:135-41.
- Tsianos EV, Hoofnagle JH, Fox PC, Alspaugh M, Jones EA, Schafer DF, et al. Sjögren’s syndrome in patients with primary biliary cirrhosis. Hepatology 1990;11:730-4.
- Lindgren S, Manthorpe R, Eriksson S. Autoimmune liver disease in patients with primary Sjögren’s syndrome. J Hepatol 1994;20:354-8.
- Furuya T, Tateishi M, Nishinarita M, Kashiwazaki S. Primary biliary cirrhosis in patients with Sjögren’s syndrome. Nihon Rinsho 1995;53:2536-9.
- Jorgensen C, Legouffe MC, Perney P, Coste J, Tissot B, Segarra C, et al. Sicca syndrome associated with hepatitis C virus infection. Arthritis Rheum 1996;39:1166-71.
- García-Carrasco M, Ramos M, Cervera R, Font J, Vidal J, Muñoz FJ, et al. Hepatitis C virus infection in ‘primary’ Sjögren’s syndrome: prevalence and clinical significance in a series of 90 patients. Ann Rheum Dis 1997;56:173-5.
- Zhang Z, Dong Y. Clinical manifestations and immunological features of primary Sjögren’s syndrome with liver involvement: analysis of thirty cases. Chin Med J (Engl) 1998;111:220-3.
- Matsumoto T, Morizane T, Aoki Y, Yamasaki S, Nakajima M, Enomoto N, et al. Autoimmune hepatitis in primary Sjogren’s syndrome: pathological study of the livers and labial salivary glands in 17 patients with primary Sjogren’s syndrome. Pathol Int 2005;55:70-6.
- Montaño-Loza AJ, Crispín-Acuña JC, Remes- Troche JM, Uribe M. Abnormal hepatic biochemistries and clinical liver disease in patients with primary Sjögren’s syndrome. Ann Hepatol 2007;6:150-5.
- Hatzis GS, Fragoulis GE, Karatzaferis A, Delladetsima I, Barbatis C, Moutsopoulos HM. Prevalence and longterm course of primary biliary cirrhosis in primary Sjögren's syndrome. J Rheumatol 2008;35:2012-6.
- Karp JK, Akpek EK, Anders RA. Autoimmune hepatitis in patients with primary Sjögren’s syndrome: a series of two-hundred and two patients. Int J Clin Exp Pathol 2010;3:582-6.
- Marcos M, Alvarez F, Brito-Zerón P, Bove A, Perez- De-Lis M, Diaz-Lagares C, et al. Chronic hepatitis B virus infection in Sjögren’s syndrome. Prevalence and clinical significance in 603 patients. Autoimmun Rev 2009;8:616-20.
- Chen MH, Hsiao LT, Chen MH, Tsai CY, Huang YH, Chou CT. Clinical significance of chronic hepatitis B virus infection in patients with primary Sjögren’s syndrome. Clin Rheumatol 2012;31:309-15.
- Gyöngyösi M, Pokorny G, Jambrik Z, Kovács L, Kovács A, Makula E, et al. Cardiac manifestations in primary Sjögren’s syndrome. Ann Rheum Dis 1996;55:450-4.
- Andonopoulos AP, Christodoulou J, Ballas C, Bounas A, Alexopoulos D. Autonomic cardiovascular neuropathy in Sjögren’s syndrome. A controlled study. J Rheumatol 1998;25:2385-8.
- Kovács L, Paprika D, Tákacs R, Kardos A, Várkonyi TT, Lengyel C, et al. Cardiovascular autonomic dysfunction in primary Sjögren’s syndrome. Rheumatology (Oxford) 2004;43:95-9.
- Lodde BM, Sankar V, Kok MR, Leakan RA, Tak PP, Pillemer SR. Adult heart block is associated with disease activity in primary Sjögren’s syndrome. Scand J Rheumatol 2005;34:383-6.
- Vassiliou VA, Moyssakis I, Boki KA, Moutsopoulos HM. Is the heart affected in primary Sjögren’s syndrome? An echocardiographic study. Clin Exp Rheumatol 2008;26:109-12.


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Table of contents
About this book
In Tiling Arrays: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to study tiling microarrays in genomic discovery . These include methods and applications for transcriptional regulation, expression, genetic and epigenetic regulation, as well as techniques and skills on tiling microarray data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Tiling Arrays: Methods and Protocols seeks to provide scientists with a comprehensive and down to earth approach to maximize results.
Editors and affiliations
- DOI https://doi.org/10.1007/978-1-62703-607-8
- Copyright Information Springer Science+Business Media New York 2013
- Publisher Name Humana Press, Totowa, NJ
- eBook Packages Springer Protocols
- Print ISBN 978-1-62703-606-1
- Online ISBN 978-1-62703-607-8
- Series Print ISSN 1064-3745
- Series Online ISSN 1940-6029
- Buy this book on publisher's site

domain: library


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Listen to an interview with George Martin from 2001 in the player below.
To properly appreciate producer George Martin, who died Tuesday at age 90, it’s better to start not with his best known clients, the Beatles, but with Gerry & the Pacemakers. Like the Beatles, Gerry Marsden and his mates were signed out of Liverpool’s Cavern Club by manager Brian Epstein and turned over to Martin at London’s Abbey Road Studios. Unlike the Beatles, the Pacemakers weren’t geniuses, merely a likable bar band.
But on two separate occasions, Martin’s own considerable gifts were enough to lift Gerry and the Pacemakers out of bar-band oblivion into artistic triumph. Both the singles, “Don’t Let the Sun Catch You Crying” and “Ferry Cross the Mercy,” were ballads capable of breaking hearts, due not to Marsden’s vocal or lyrics but to Martin’s brilliant orchestral charts.
Channeling his hero Nelson Riddle (who wrote similar charts for Frank Sinatra’s greatest records), Martin used hovering, unresolved string parts that didn’t push heartache on the listener but rather evoked the anxiety that makes heartbreak possible. When the wistful woodwinds added an element of melancholy, the listener could find one’s own sorrow without being manipulated by the arrangement. It was great art, but the art was Martin’s, not the performers listed on the label.
This, of course, refutes the rock ‘n’ roll myth that the music only gets worse when the record-company man interferes with the musicians’ work. Martin was very much a company man. He was on the staff at EMI’s Parlophone Records in London and had already produced several hit comedy records when he took on the Beatles, Gerry and the Pacemakers, Cilla Black, the Vipers and Billy J. Kramer during the label’s early foray into rock ‘n’ roll. But a record-company guy can also be an artist, as Martin soon proved.
But just as singers and guitarists are artists who can be either good or bad, depending on the underlying talent and the choices made, so can producers. Compare, for example, the transcendent production done by Phil Spector before 1967 and the heavy-handed interference he practiced afterward. In the 1960s, Martin made the choices necessary for great art. He knew enough to take the lead with a lesser artist like Marsden and to take a complementary role with greater artists such as John Lennon and Paul McCartney.
Martin pushed the two songwriters into two crucial decisions that made the Beatles’ historic run possible. First of all, he told them point-blank that they needed a better drummer than Pete Best. So they hired Ringo Starr.
Second, Martin told them that if they didn’t want to record songs like Mitch Murray’s “How Do You Do It” (which the producer had the Beatles record before turning it over to Gerry and the Pacemakers for the latter’s first UK No. 1 hit), they’d have to write better songs than “Love Me Do” or those churned out by London’s professional hacks. So Lennon wrote “Please Please Me” with an arresting IV-II-VI-IV-I progression to start the chorus.
Martin was impressed, but it wasn’t until he insisted that the arrangement be altered from a Roy Orbison-like ballad to an Everly Brothers-like pop-rocker that the song really clicked. Before long, McCartney countered Lennon with “All My Loving,” and the fruitful songwriting competition to impress each other—and Martin—was off and running.
And once that competition reached a certain level, Martin’s background as a classically trained arranger and as a vanguard tape editor (he once spliced in the sound of a cabbage being chopped in half for a Peter Sellers comedy skit about a beheading) became invaluable. When “Yesterday” reminded Martin of Bach, the producer insisted that McCartney, against the singer’s wishes, record the song on acoustic guitar backed only by a string quartet playing a Martin chart. Lennon, Starr and George Harrison weren’t involved on this, one of the greatest English-language records of the 20th century, but Martin, often called the “Fifth Beatle,” was.
Martin wrote the chart for the trumpet on “Penny Lane,” the flute on “You’ve Got To Hide Your Love Away,” the string quartet on “Eleanor Rigby,” the French horn on “For No One,” the tablas on “Love You To” and the orchestral crescendo on “A Day in the Life.” He played the piano keys on “In My Life,” the piano strings on “Getting Better,” the harmonium on “Word” and the organ on “Got To Get You Into My Life.” He taught “the lads,” as he called them, how to use chopped-up or backwards-running tape to create sound effects on songs such as “Strawberry Fields Forever,” “Being For the Benefit of Mr. Kite!,” “I’m Only Sleeping” and “Tomorrow Never Knows.”
After the Beatles broke up in 1970, Martin, like the band members themselves, never achieved such artistic heights again. Each of the five men created admirable, enjoyable music in the future, but they apparently needed each other to make truly great records.
This was especially true of Martin, whose great gift was arranging, not composing. The incidental music he composed for the A Hard Day’s Night and Yellow Submarine movies was nice but forgettable. He produced Elton John’s 1997 version of “Candle in the Wind,” three of McCartney’s solo albums, two Jeff Beck albums, the Mahavishnu Orchestra’s Apocalypse and Cheap Trick’s All Shook Up, but it wasn’t the same.
In his later years, Martin allowed himself to be pulled back to the Beatles catalog again and again. He oversaw the music for the The Beatles Anthology TV specials and accompanying CDs in 1995-96. He toured the world with a multimedia presentation on the making of Sgt. Pepper. With his son Giles, Martin sampled tracks from 120 different Beatles songs, created new tracks and remixed everything into an 80-minute, 27-segment audio collage for the 2006 Cirque de Soleil production Love and its soundtrack album. By then, his health was already failing.
Lennon and McCartney were so talented and so ambitious that they would have made important records even without Martin as producer—or without Starr as drummer. But those records wouldn’t have been as important, and that difference is the measure of Martin’s contribution (and of Starr’s as well). After all, the producer could make even Gerry and the Pacemakers sound special.

domain: artistic


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Timings of 300 Northern Railway trains to change soon
The departures of 57 trains have been preponed while 58 trains have been postponed in the new timetable. The arrivals of 102 trains have been preponed while 84 trains have been postponed.
Government will not allow slaughterhouses in Uttarakhand: CM
"We will not allow opening slaughterhouses in the state. Those issued by previou...
CBSE's training centre would be opened in Dehradun soon
The state government has already allotted land for setting up CBSE regional office in...
Adani walks away with gas rights for 21 cities; BPCL bags 11 cities
According to the Petroleum and Natural Gas Regulatory Board (PNGRB), IOC on its own won rights to seven cities, including Coimbatore and Salem in Tamil Nadu and Guna in Madhya Pradesh.
Watch: PM Modi performs Yoga Asanas in Dehradun
Prime Minister Narendra Modi joined thousands of volunteers and performed yoga asanas in Uttarakhand's Dehradun on 4th International Yoga Day today. The event was held in the Forest Research Institute (FRI). International Yoga Day is celebrated annually on 21 June since its inception in 2015.
Meet the man who steered Mercedez Benz back to pole position in India
India's private equity industry is having quite a moment: big returns, high-profile departures, regulatory tailwainds and new money.
Meet the man who steered Mercedes Benz back to pole position in India
Roland Folger led Mercedes to the top in India. The luxury car maker now has a 3-pronged strategy for the future.
All set for Yoga Day, PM to lead enthusiasts in Dehradun
Yoga sessions will be held across the world to mark the day, picked by the United Nations to celebrate the ancient Indian practice that has spread across the globe.
Are environmental issues finally an important part of India's election discourse?
Over the past year, the national capital has garnered the most attention for environmental issues, compared to other major cities in the country.
Manpasand to invest Rs 1,500cr to set up 10 new plants by 2020
The company at present has six manufacturing plants across the country, of which three are in Vadodara, and one each in Varanasi, Dehradun and Ambala.
Yoga Day 18: 'From Dehradun to Dublin, Shanghai to Chicago, yoga's everywhere', says PM Modi
Yoga sessions are being held across the world to mark the day, picked by the United Nations to celebrate the ancient Indian practice that has spread across the globe.
International Yoga Day: Join PM Narendra Modi in Dehradun to gain more insight
Three venues in Dehradun that were shortlisted for International Day of Yoga are seeing a stream of enthusiasts for a week now.
No proposal to make it mandatory for students to go for military education: Government
Subhash Bhamre, minister of state for defence, said this in a written response to a question in Rajya Sabha.

domain: news


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Songmasters has announced Listen To Me: Buddy Holly, a new collection benefitting the Grammy Foundation and featuring contemporary takes on songs originally written and performed by Recording Academy Lifetime Achievement Award recipient Buddy Holly.
The album is the inaugural release in Songmasters’ yearlong Listen To Me series of multimedia celebrations of the artists who forever changed modern music and culture. Each campaign features today’s leading and emerging artists paying tribute to their musical roots to raise support and awareness for the next generation of songwriters, performers and entrepreneurs. Sales from the albums will directly benefit the GRAMMY Foundation. For more information, visit www.listentomebuddyholly.com.


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Gone Girl. The #1 New York Times Bestseller. On a warm summer morning in
North Carthage, Missouri, it is Nick and Amy Dunne's fifth wedding anniversary.
Directed by David Fincher. With Ben Affleck, Rosamund Pike, Neil Patrick Harris,
Tyler Perry. With his wife's disappearance having become the focus of an ...
https://en.wikipedia.org/wiki/Gone_Girl_(film) - 12 hours ago
Gone Girl is a 2014 American psychological thriller film directed by David Fincher
. The screenplay by Gillian Flynn was based on her 2012 novel of the same ...
Gone Girl is a thriller novel by American writer Gillian Flynn. Crown Publishing
Group published the novel in June 2012, and it soon made the New York Times ...
Dark, intelligent, and stylish to a fault, Gone Girl plays to director David Fincher\'s
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THE #1 NEW YORK TIMES BESTSELLER On a warm summer morning in North
Jul 7, 2014 ... More Gone Girl News ▻▻ http://bit.ly/GoneGirlNews Subscribe for TRAILERS ▻
▻ http://bit.ly/JoBloTrailers Director: David Fincher Writers: ...
Official Gone Girl movie site. Directed by David Fincher and based upon the
global bestseller by Gillian Flynn. Now on Blu-ray, DVD & Digital HD.
http://www.goodreads.com/book/show/19288043-gone-girl - 16 hours ago
Gone Girl has 1253650 ratings and 112832 reviews. Tatiana said: As seen on
The ReadventurerI am giving Gone Girl 3 stars, but only begrudgingly. In ...
Gone Girl. 679702 likes · 2123 talking about this. Gone Girl, directed by David
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Mini Regaliz 10x5mm Stitched Blue Jeans Oval Leather by the Inch
Give your designs a unique leather foundation with the Mini Regaliz 10x5mm stitched blue jeans oval leather. This leather features a half moon shape. One side is rounded, while the other side is flat. What makes this stringing material unique is the stitching along the edges of the leather. It creates a textured, dimensional look full of style. This leather features a denim blue coloring. It would pair well with rich browns and creamy neutrals. This leather is sold by the inch, so you can order just the right amount for your needs.
To see all products from this brand please click here.
Regaliz™ offers leather, slider beads and other compatible components that work together to create fashionable bracelets everyone will love.

domain: design


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As a general rule, movie titles are not underlined they are placed in italics the use of italics for movie titles is the commonplace practice since the ubiquitous. You might need to use modern language association start with the title of the film in italics quote and cite a poem in an essay using mla format. Are band names italicized in writing according to the ap stylebook italics are necessary only in mla or apa format just like a movie title or book title. According to a pocket style manual by diana hacker film titles should be italicized when typed and underlined any other time this is proper mla formatting. A lot of people have trouble formatting titles correctly in an english class, how you format the title of a work (a book, an article a film: underline or. A complete guide to mla 8 ★ formatting the title if the focus was on the whole film or television.
Do you underline, italicize, or put in quotes for a movie title film titles are underlined or in an mla format you are instructed to use. Read here to learn how to add a title to an mla 8th edition citation includes books in mla 8, periodicals in mla 8, and television shows in mla 8. Dealing with titles in mla format by dr harold william halbert the conventions of properly marking a title in mla style can seem confusing, but the basic issues.
Film/video citation examples (august 2010) modern language association (mla) citation format is most commonly used for film and title of film [medium. Formatting an essay in mla style write the date in the day month year format, as in 14 may 2010 title of your essay formatting titles of texts in mla style. How do you format movie titles in since the period at the end of the sentence is not part of the movie title how do you format the title of a poem in an.
Mla in-text citations film titles of film and recording titles should be underlined or put into italics modern language association mla handbook 8th ed. Titles of works the titles of certain works are indicated with quotation marks and the mla handbook for writers of research papers (7th ed).


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5 Minute Meditation – Our Most Popular Stress Busting Technique. A 5 Minute Meditation Technique that helps you bust anxiety and stress levels in just over 4 minutes. A meditation tool that kids love, teenagers love, busy stressed out executives use every day....
How To Recover From Post Traumatic Stress Disorder And Trauma – The Natural Way What is Post Traumatic Stress Disorder? So what is Post Traumatic Stress Disorder? According to PTSDuk “… PTSD is considered to be a psychological injury rather than...
10 Ways To Reduce Menopause Symptoms Naturally Proven and effective natural ways to reduce menopause symptoms Many women struggle through the menopause seeking a natural way to reduce menopause symptoms without resorting to medication. It’s a downward cycle,...
Stress Management For Kids And Teenagers Why Stress Management For Kids Is So Important Today Sadly anxiety, depression, and stress is becoming a rapidly increasing problem for many kids and teenagers today. We know how much stress management is important for adults,...
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domain: psychology


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Click through to see the entire gallery!
This town knows music. On any given night, you can find whatever genre you're jonesing to hear, sing, or dance along with. Here's a taste of what happened in the San Francisco music scene the past seven days...
50 Things to Do in Berkeley
50 Things to Do in Oakland
Top 7 Breweries in Berkeley and Oakland
Where to Go Swimming in the East Bay
Top Wineries in Livermore
7 East Bay Patios to Dine al Fresco
East Bay Answers to Your San Francisco Rut

domain: geography


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Did we covet our neighbour 5 goods? I might just as well be a sinner like you. As we mounted the steps back to the main road, she looked at me suspiciously.
This section contains words approx. I have told how states were formed and battles fought. She could hear his steady breathing as she crossed over to stand by his bedside. Eventually the state of Illinois acquired it, where it's preserved at the Abraham Lincoln Presidential Library and Museum.
He likes to make small connections with his charges and ask about their families. Read "Snow" words I stayed there till Mother came in from work and made my dinner, but when Father came in later, Nora said in a shocked voice: Ryan's story made a bad confession; it seemed to me a great shame that people wouldn't stop criticising him.
Voice is the peculiar vocabulary, tone, and phrasings our characters use. Feld equates wealth with happiness, and as he is just a struggling cobbler, he wants Miriam to be wealthier, and thus happier, than he has been.
Being always very ambitious I was The first seven years short story to volunteer, but I thought it might look greedy. It was my turn now. She was waiting for the national bulletin to finish and the local report to come on.
Read "Yours" words The merchant sells another product at a much higher price to make up for it. But, in a larger sense, we can not dedicate -- we can not consecrate -- we can not hallow -- this ground.
How could he not? She doesn't know how it got there, and she thinks about how it has been alone for so long. It was pitch-dark and I couldn't see priest or anything else. Wealth and Happiness Though his actions are somewhat misguided, ultimately Feld has noble goals for his daughter: She takes porter, father," I said, knowing well from the way Mother talked of it that this was a mortal sin, and hoping it would make the priest take a more favourable view of my case.
She may have mentioned the other place as well, but that could only have been by accident, for hell had the first place in her heart. In fact, the title of this post is misleading because there is really no such thing as the perfect first line.
He had to put his head on one side to see me, and I had to put mine on one side to see him, so we were more or less talking to one another upside-down. Photo by Nawal Al-Mashouq Creative Commons Great first lines have that power, the power to entice your reader enough that it would be unthinkable to set the book down.
Eventually, Feld is able to see past the appearances of each character, ultimately rejecting Max as a possible suitor for his daughter, and accepting Sobel. I don't know will I get rid of you at all today. His family waits for him on the front porch, eager to know if the house will be lost.
The world will little note, nor long remember what we say here; while it can never forget what they did here. Then the priest knew it was a bad case, because the fellow was after making a bad confession and committing a mortal sin.
Suitable for ages 10 to years old…. Walt was one of five children, four boys and a girl. Walt Disney is a legend; a folk hero of the 20th century. It only stood to reason that a fellow confessing after seven years would have more to tell than people that went every week.
Two things I was well aware of: Keep searching for it. Grateful for their safe haven and the generosity of their host, the queen and her courtiers embrace their new surroundings with delight.
Therefore I knew, beyond doubt or question, that the world was mistaken about this hero: Walt began to love, and appreciate nature and wildlife, and family and community, which were a large part of agrarian living. A whole lifetime goes by and it's nothing, not even a drop in the ocean of your sufferings.
He does not take into consideration, however, the fact that he is an exceptionally well-read man, as is his daughter, as is his apparently lowly assistant, Sobel. What a large portion of our troubles would be done away if we knew the whole truth!Other short stories by Mark Twain also available along with many others by classic and contemporary authors.
short stories interactive word games. Mark Twain. The £1, Bank-Note. When I was twenty-seven years old, I was a mining-broker's clerk in San Francisco, and an expert in all the details of stock traffic.
The first thing I. In The First Seven Years by Bernard Malamud we have the theme of desire, love, insecurity, conflict, independence, appearance and change.
Taken from his The Complete Stories collection the story is narrated in the third person by an unnamed narrator and after reading the story the reader realises that Malamud may be exploring the theme of desire and insecurity.
Watch video · The first celebrations included “play parties,” public events held to celebrate the harvest, where neighbors would share stories of the dead, tell each other’s fortunes, dance and sing.
The first time I heard about the Seven Point Story Structure was through a presentation Dan Wells did a couple of years ago. I saw the presentation in a series of clips on Youtube (Part 1, Part 2, Part 3, Part 4, Part 5).Watch it, it’s a great and informative presentation. Mar 01, · "The First Seven Years" establishes the story line that would permeate the series for the next year.
Jackie is the leader, he loves Mary Ann, and has to put up with his brother, Wheezer. An early talkie bright spot in the series/10(). Nov 15, · Milwaukee reached the playoffs for the first time in seven years, swept Colorado in the Division Series then lost to the Los Angeles Dodgers in a seven .Download

domain: literature


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Before being named the CEO of Strategic Brands Group in January 2015,Vora was the SVP, Marketing, Flipkart between April 2012 and December 2014. It was then reported that Flipkart had named Mukesh Bansal as its new marketing chief.
Mukesh Bansal (CEO and co-founder of Myntra.com, who became part of Flipkart's board, after the company acquired Myntra in May this year) was responsible for product verticals like computers and consumer electronics, and will market the company's private label brands too.
Ravi Vora has been instrumental in building the Flipkart brand over last four years from a small base to undisputed leader in India's exponentially growing E-commerce space. He set up the marketing team from scratch with experts across domains of Brand marketing, Mobile, SEM, SEO, Social media, Email and Affiliate marketing. The team helped Flipkart reach a topline of $3B, a customer base of 30 million and a daily traffic of 10 million (Jan’15).
An alumnus of IIM Bangalore and BITS Pilani, Ravi spent substantial part of his initial career at Hindustan Unilever Ltd., working on brands like Brooke Bond, Annapurna and Kissan.
"The total estimated sales of smartphones for the year are revised at 128 million units, against the earlier estimates of 127 million released in June. Flipkart and Amazon estimated to sell 15 million smartphones during the festive sales period, which is 36.58 per cent of the total estimated sales for the October-December quarter," the report said.
In a letter to Commerce and Industry Minister Piyush Goyal, the Confederation of All India Traders (CAIT) said, "We are of the considered opinion that direct selling is an integral part of the retail trade like other verticals including big retail, small retail, e-commerce and self employed groups."


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We present the Low Verbal Investigatory Survey (eLVIS), a 30-item parent-report measure designed to assess communicative capacity in autism spectrum disorder (ASD). The eLVIS is short, easy to complete, and based on the atypical language trajectories specifically found in individuals with ASD. Early results from a sample of almost 150 children ages 1- 8 years suggest that LVIS scores are informative about communicative capacity, and capture multiple communication dimensions in children with minimal verbal skills.
To complete the LVIS, click on the “Participate” link to the right.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.


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Help is on the way, Louisiana entrepreneurs! Our team is assembling a list of entrepreneurial resources in the Tallulah area.
Louisiana Entrepreneurial Resources
This is Step One. If you haven't already done so, browse our list of Louisiana entrepreneurial resources. These state-level resources can be very useful to Tallulah entrepreneurs . . . and any entrepreneurs in Louisiana for that matter.
We've got information on venture capital groups in Louisiana, Louisiana angel investors, instructions on how to incorporate in Louisiana and much more.
Use the link below to access our Louisiana entrepreneurial resources:
Useful Information on Tallulah, Louisiana
Did you know that approximately 9,000 people live in Tallulah? That's the count according to recent census data.
Tallulah, Louisiana Newspaper Advertising
Want to advertise a Tallulah, LA business? If you are already doing business in Tallulah, it's important to get the word out and attract new customers. Newspaper advertising is a proven way to bring in new business.
Fortunately, we've made it easy to find out how much newspaper advertising costs in Tallulah, Louisiana.
Starting a Business in Tallulah, Louisiana
If you are a new entrepreneur, just going into business for the first time, we've isolated some key steps for starting a business in Tallulah, LA.
Business Demographics for Tallulah, Louisiana
Tallulah has more than 100 businesses operating within its borders. The most common types of business are shown in the table below:
|Business Type||# of|
|Offices of Lawyers||9|
|Residential Mental Retardation Facilities||7|
|Home Health Care Services||6|
|General Automotive Repair||5|
|Drinking Places (Alcoholic Beverages)||4|
|All Other General Merchandise Stores||4|
|Farm Supplies Merchant Wholesalers||4|
|Gasoline Stations with Convenience Stores||4|
|Grain and Field Bean Merchant Wholesalers||4|
|Lessors of Residential Buildings and Dwellings||4|
|Offices of Physicians (except Mental Health Specialists)||4|
|Office Administrative Services||3|
|Other Gambling Industries||3|
|Other Individual and Family Services||3|
|Other Residential Care Facilities||3|
|Pharmacies and Drug Stores||3|
|Soil Preparation, Planting, and Cultivating||3|
|Specialized Freight (except Used Goods) Trucking, Local||3|
|Supermarkets and Other Grocery (except Convenience) Stores||3|
|Automotive Parts and Accessories Stores||2|
|Automotive Body, Paint, and Interior Repair and Maintenance||2|
Business Resources in Other Louisiana Cities
Sulphur Entrepreneur Resources
Thibodaux Entrepreneur Resources
All Cities in Louisiana
General Entrepreneurial Resources
If you are new to our site, be aware that we have thousands of useful articles for entrepreneurs. Whether you live in Tallulah, Louisiana or anywhere in the world, these articles will get you started as an entrepreneur and help you move along the path to business success.

domain: economics


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Thea Gouverneur is a classic example of counted cross stitch company with traditions in needlework. Big, stylish designs of landmarks, cottages and icons- all of those kits have European quality and best materials
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How to create Black cat manga wallpaper%A
Making an anime is not any simple job. It’s an entire procedure for building and illustrating a world, finding motivations, weaving testimonies – this is a major undertaking! However, it’s also a great exercise in creativity. If you’re passionate about anime you’ll probably enjoy making your own.
Method 1 : Outlining a global
Find out where you want your history to be establish. Is it heading to be on an alien globe? Is it going to be on a place that is relatively similar to places on the planet? You don’t need to figure out everything about the complete world, nevertheless, you do need to figure out where you want your report to occur.
For example, perhaps you want the major action of your report that occurs in a global where most people reside in caves because outside of caves there are a lot of dangerous slime pits that you could fall into.
Find the interesting reasons for having your world. Like slime pits! Animes frequently have parts of their world that are slightly magical or strange in some way. Maybe pianos discussion and give people lots of advice. Maybe there are flying beasts that individuals use to get from spot to place. It doesn’t have to be something extremely fantastical or something out of your science fiction novel – just decide on something that works together with your world and your story.
For example, the magic of the world could be a simple folk tale that may or might not be true. Maybe on the slime pit world there is a story that if you fall into a slime pit and survive you will be granted special power but nobody recognizes if this holds true or not.
Decide the technical advancement of the world. Are the residents of your world living in apartment complexes or in real wood huts? Are they trying to find their food, or can they go out to meal are restaurants? Certainly there are always a ton of other options in between and beyond these good examples. The technological position of your world will inform most of the ways that your characters connect to the issues that face them.
For example if someone comes into a slime pit in a technological advanced world, maybe it’s no big offer because everyone would wear anti-slime suits.
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Dear Twitpic Community thank you for all the wonderful photos you have taken over the years. We have now placed Twitpic in an archived state..
Method 2 : Creating Characters
Choose what they look like and their personalities. You should attempt to decide what they look like at the same time that you decide their personalities. Try drawing the characters and then jotting down beside them what their personality characteristics would be. Perhaps you have one persona that is actually brilliant and perceptive but prone to sacrificing their temper. Perhaps you have another personality that is very faithful but very unkind to strangers. Sketch drafts of your characters.
What sort of personas look is important because it can play into their personality. For instance, maybe the very muscular personality is the hero. Conversely, maybe the muscular figure is a total coward. Either way, his body informs his personality in an interesting way.
Decide on a protagonist. You don’t have to have just one main personality, but it’s nice to give the reader an individual to root for. Most anime have a protagonist.
Consider providing them with special skills. Anime often feature personas with special talents accomplishing outstanding things. It could be smart to give your primary character some kind of power that will help her or him deal with whatever the situation in your anime is likely to be. Your character doesn’t have to be able to travel or have very strength – find something small and interesting that helps the character deal with unique challenges.
For example, maybe your identity is incredibly courageous! That is clearly a special ability, but it is not magic.
Create relationships between the characters. Family, love interests and friends of your protagonist should all play a significant role in your story. They are the strongest connections that folks have with others and they help motivate, motivate, and create issue. All of those things are positive characteristics in a great story.
Find out each characters motivation. The other personas can play into your characters inspiration, but find a unique thing that drives them. It could be getting educated or getting the girl, it just must be something that the protagonist is very interested in.
Method 3 : Beginning to Animate Your Anime
Start by sketching your world in an animation program. You can find many free web computer animation programs online that allow you to easily create a world and persona. You’ve already made a decision what you would like the world the appearance like, so now you merely need to take it to life. Take your time and don’t stress if it changes from your original plan.
Draw your character types. Make your heroes in the same animation program. Refer to the drawings and sketches that you have previously done to be able to see your final product.
Draw your heroes interacting with the world. Now all you have to do is combine the individuals and the planet. This will likely immediately begin to give you ideas for tales and potential story lines to check out. Maybe your character types want to explore those significant cliffs out in the length they have never been to before. Maybe sunlight is getting dimmer and dimmer each day plus they have to determine what is going on. The environment can be considered a huge impetus in any story, and anime is not any different.
For instance, maybe your world has gigantic slime pits everywhere. Maybe your primary characters little sibling falls into one of the slime pits and the other personas have to figure out a way to save him. You now have the start of a plot!
Method 4 : Incorporating Story and Dialogue
Combine dialogue that complements the motivation and personalities of the character types. Once you’ve characters and a global you can start turning the character types interacting with the globe into a story. This involves creating dialogue. Use dialogue that suits the problem and the character. Make an effort to make the dialogue as realistic as possible. Take into account the way you talk and create interactions like that. Discussions are seldom 100 % directed. They sway and change subject constantly. Figure out a way to add authenticity, and laughter to your dialogue.
Make sure that you have a newbie, middle, and end. The beginning, midsection, and end does not have to be incredibly distinctive, but keeping this corporation in mind will help you plan out your plot. Take a look at other classic catalogs and start to figure out what the beginning middle and end of these stories are.
For instance, maybe the start of your anime has the protagonist’s little sibling falling in a slime pit. The middle could be whenever your protagonist deciding to travel alone into the slime pit using an anti-slime suit to try to find his little brother. The end would be the thrilling conclusion where the slime demons residing in the slime pit allow only one of the brothers to leave, and your protagonist continues to be behind so that his little sibling can go home.
Include a personality arc. Figure arcs don’t need to be really simplistic and dreary. Not every storyline has to begin with a sad identity and end with a happy persona. Rather, a figure arc should allow the primary character to undergo some sort of minor change or come to a realization. Even though that realization is the fact that nothing improved from when the story started, that still offers a aspect to the storyline. Everything you don’t want is your persona just running around doing assorted activities without the chain of reasoning.
For example, maybe your protagonist is selfish at the beginning of the story but after assisting save his brother he starts to understand that he does indeed care about other people but that he was shutting himself off to the globe. You will address why he was shutting himself off to the world within the next episode.
Related images to black cat manga wallpaper%A
Method 5 : Finishing Your Anime
Think about a good title. The title is what catches people’s attention. Make certain the subject has something to do with the plot.
Decide if you would like your anime to be one report or a series. This may determine how your account ends, or if it ends at all. If you want your stories to be always a series then you have to determine ways to keep people interested. If everyone is satisfied with what sort of first story concluded, then there is no reason behind them to watch your next episode. Create cliffhangers.
Add a thrilling climax and bottom line. This is a large part of creating a cliffhanger. If you are making multiple episodes you want to balance the range between concluding the previous episode and setting the next event up. They shouldn’t feel like they watched the first occurrence for nothing, but the viewer also needs to be excited to see what goes on next. Find this balance.
Tie up the knots in your story. If there is a love interest at the start of the story, there should be some acknowledgement of this by the end of the storyplot. Not everything needs to tie up perfectly, nevertheless, you want your anime to look well designed and professional. When you have a couple of untied account lines it feels messy.
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Human tissues expertise a spread of mechanical stimuli which will have an effect on their ability to hold out their physiological functions, like protective organs from injury. The controlled application of such stimuli to living tissues in vivo and in vitro has currently tried instrumental to finding out the conditions that result in malady.
At EPFL, Selman Sakar’s analysis team has developed micro-machines ready to automatically stimulate cells and micro-tissue. These tools, that area unit supercharged by cell-sized artificial muscles, will do difficult manipulation tasks underneath physiological conditions on a microscopic scale.
The tools include micro-actuators and soft robotic devices that area unit wirelessly activated by optical maser beams. they’ll conjointly incorporate micro-fluidic chips, which implies they’ll be accustomed perform combinatorial tests that involve high-throughput chemical and mechanical stimulation of a spread of biological samples. This analysis has been printed in Lab on a Chip.
The scientists came up with the concept when perceptive the locomotive system in action. “We needed to form a standard system supercharged by the contraction of distributed actuators and also the deformation of compliant mechanisms,” says Sakar.
Their system involves collection varied gel elements — as if they were plaything bricks — to create a compliant skeleton, and so making tendon-like compound connections between the skeleton and also the micro-actuators. By combining the bricks and actuators in numerous ways that, scientists will produce Associate in Nursing array of difficult micro-machines.
“Our soft actuators contract chop-chop and with efficiency once activated by near-infrared light-weight. once the whole nano-scale mechanism network contracts, it tugs on the encompassing device elements and powers the machinery,” says Berna Ozkale, the study’s lead author.
With this technique, scientists area unit ready to remotely activate multiple micro-actuators at mere locations — a deft approach that produces exceptional results. The micro-actuators complete every contraction-relaxation cycle in milliseconds with massive strain. In addition to its utility in elementary analysis, this technology offers sensible applications still. as an example, doctors might use these devices as small medical implants to automatically stimulate tissue or to actuate mechanisms for the on-demand delivery of biological


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As a child, I’d enjoy many hours colouring with crayons and painting with my paint pots, creating and stretching my imaginative ideas then setting up a roadside stall to offer my works of art for sale.
These days, I create full time and my seaside studio is open for friends and passers-by to drop in for a chat, coffee (or wine!) and view my works of art for sale.
From oil paintings, concrete bottle art and mosaics, my imagination is constantly on the run, but it is my love of colour & design that has led me into working in a variety of mediums.
Such a thrill when the final touches are made and another “favourite piece” emerges.
Contact me by email to make a purchase. You can pick up items directly from me or we can arrange post/courier at your cost. (My birdbaths are pickup only – they are too heavy to post!)


The last year has been a roller coaster ride for Michael Dyer.
After an up and down career at Auburn, Dyer transferred to Arkansas State, but the NCAA denied his appeal to play immediately this season. Rumors began to swirl regarding Dyer's next move, with multiple reports having the running back land in Division-II.
But Dyer will not play football in 2012. Instead, he will enroll at a school close to home in Little Rock, Ark., according to ESPN's Joe Schad.
Dyer, a former offensive MVP of the BCS title game, was once a promising NFL Draft prospect, but his stock is up in the air at this point. It seems unlikely that Dyer would declare for the 2013 NFL Draft, and if he does, his stock has certainly taken quite the hit at this point.
Like Tyrann Mathieu, though, Dyer could be making the right decision for himself personally. Some time away from football could be good for him to sort things out and decide on the best option for his future.


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Do you know what you have in you?
Regardless of who we are the one thing that is always true is that our future lies before us. When your dreams beckon, your past triumphs, and even your past failures, may not be enough to overcome new and unexpected risks and obstacles. In those moments, the question truly becomes, Can you go more than you have gone already? Can you fulfill your dreams?
Crippled by an unexpected injury, avid runner Henri struggles to reclaim his passion. Trained as a competitive hurdler, he now must overcome the biggest hurdle of his life. Cleared to race again a er three long years, the fear of being re-injured haunts him. In the meantime, Henri has found other tasks and passions to fill the void. Challenged with following his true passion, he begins to find himself. Henri begins to realize who he is, and it may not be who he thought he was.
Erica Seifried’s debut novel, More Than Miles explores the intersections between goals, dreams, identity, and friendship. To achieve your dreams, drive and confidence are essential, but are they everything? More than ever in our hyper-competitive, hyper-driven society, we should take up the challenge of More Than Miles and wrestle with the question: “Do I know what I have inside me?”


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Defensive Edge Cheek Piece for the Rem 700 PSS, Sendero HS Precision stocks, MIA Factory stocks, Winchester Varmint and many others. Black in color
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Sal Marina del Delta del Ebro fused the aromas of Moncayo, Romero and Thyme. It is #225; handmade, without preservatives or dyes.
Naturally get the taste of food, spice up and add a touch of distinction #243;n to your dishes. Best pairing would be roasts #243, game animals, legume and grilled red meats. We also #233;n grilled and cooked preparations in #243;n.
Condiments and naturally enhances the flavor of your dishes. It is ideal for roasts, pickles, stews, legumes and fish. You can buy it from the Post Office

domain: food


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Since its opening a year ago thanks to the support of the Veolia Foundation, the Niamey Oasis has been welcoming Nigerian women to facilitate their economic integration. Objective: promote entrepreneurship by raising awareness of the challenges of sustainable development and resource conservation. The first anniversary, celebrated in the presence of representatives of the Veolia group and under the sponsorship of Elback Zeinabou Tari Bako, Minister for the Advancement of Women and Child Protection, provided an opportunity to take stock.
In one year, the Oasis hosted 63 events attended by 2,500 people. At the same time, 686 women developed their entrepreneurial management skills, enabling them to develop a profitable business. This social and environmental dynamic extends beyond L'Oasis: indeed, many women share the knowledge and skills acquired in L'Oasis within their neighbourhood, through collective organizations or workshops.
The Oasis is a project led by Empow'Her in Niamey, capital of Niger,.
>> More about.


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With a stay at Good Stay Hotel Dinaburg in Daugavpils, you'll be minutes from St. Boris and Gleb Cathedral and Daugavpils TV Tower. This hotel is within close proximity of Daugavpils Central Park and St. Peter's Church.
Make yourself at home in one of the 57 guestrooms. Complimentary wireless Internet access keeps you connected, and satellite programming is available for your entertainment. Housekeeping is provided daily, and both irons/ironing boards and cribs/infant beds (complimentary) are available on request.
Take advantage of recreation opportunities including an indoor pool and a sauna. Additional amenities at this hotel include complimentary wireless Internet access and tour/ticket assistance.
Satisfy your appetite at the hotel's restaurant, which serves breakfast, lunch, and dinner, or stay in and take advantage of room service (during limited hours).
Business, Other Amenities
Featured amenities include dry cleaning/laundry services, a 24-hour front desk, and luggage storage. Free self parking is available onsite.

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The System Is Working 24/7: Biden Cancels $10,000 In Student Debt For Millions
US President Joe Biden will cancel up to $10,000 (£8,474) in federal student loans for millions of Americans who earn less than $125,000 each year.
Mr Biden will also forgive $20,000 of debt for students on Pell Grants, which applies to those in greatest financial need.
The president will provide the details of his plan at 14:15 EST (18:15 GMT).
An estimated 43 million Americans owe a combined total of $1.6tn in federal student debt.
Nearly one-fifth owe less than $10,000.
“My administration is announcing a plan to give working and middle class families breathing room as they prepare to resume federal student loan payments in January 2023,” Mr Biden said on Twitter.
The temporary student loan pause, first put in place in March 2020, will also be extended a final time until 31 December of this year.
The announcement follows more than a year of intense internal White House debate and mounting pressure from progressive Democrats. Top Democrats Senate Majority Leader Chuck Schumer of New York and Senator Elizabeth Warren of Massachusetts, are among those who had pushed Mr Biden to use his executive power to wipe out borrower debts.
Wednesday’s plan falls short of the $50,000 per borrower plan that Mr Schumer and Ms Warren had asked for.
A one-time cancellation of $10,000 for each borrower earning a maximum of $125,000 will cost the federal government around$300bn, according to an estimate from the Penn Wharton budget model at the University of Pennsylvania.
Republicans and some moderate Democrats have said debt cancellation will add to inflation by giving Americans more money to spend. And others say that blanket debt forgiveness is unfair to those who have already paid off students loans.
House minority leader Kevin McCarthy, a Republican from California, quickly criticised the plan on Twitter: “Who will have to pay for Biden’s debt transfer scam? Hard-working Americans who already paid off their debts or never took on student loan debt in the first place,” he wrote.
Some Democratic lawmakers have pushed back, saying that cancelling student loans helps address economic racial disparities.
Black students are more likely to borrow federal student loans and at higher amounts than other Americans. Four years after earning bachelor’s degrees, black borrowers owe nearly $25,000 more than their white peers on average, according to a Brookings Institution study.


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3 Kg open top Carton
An apricot is a delicious and nutritious fruit. It has a delicate and fragrant flavor that is delightful to the senses. It is rich in vitamin A, which helps improve your vision and skin health. An apricot is a perfect fruit for any occasion, as it can be eaten fresh, dried, or canned.

domain: health


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President Vladimir Putin, during a working meeting, proposed Dmitry Artyukhov, deputy governor of the Yamal-Nenets Autonomous District, to lead the region. His predecessor, Dmitry Kobylkin, went to work in the White House. Mr. Artyukhov will be the youngest in the Russian governor's corps.
Dmitry Kobylkin as head of YaNAO was replaced by his deputy Dmitry Artyukhov. According to Kommersant's information, he, like the appointed Governor of the Tyumen region Alexander Moore, held so-called courses for the training of governors and was a reserve managerial personnel under the patronage of the presidential administration (see "Kommersant" on November 9, 2017), took part in competition "Leaders of Russia".
The former head of YaNAO, Dmitry Kobylkin, who headed the region since 2010, became Minister of Natural Resources and Ecology.
Dmitry Artyukhov became the youngest representative of the governor's corps in Russia - he was only 30 years old this year. Prior to this, the status of the "youngest" head of the region was Anton Alikhanov, governor of the Kaliningrad region (1986). Mr. Artyukhov was born in Yamal, after graduating from the magistracy and postgraduate studies of the Tyumen State University he received an MBA from the Singapore University of Management. In the office of the governor he has been working since 2010, in 2016 he became deputy head of the region.
In the Yamal-Nenets Autonomous District, which is part of the "matryoshka" entity of the Russian Federation (the Yamal-Nenets Autonomous District and the Khanty-Mansiysk Autonomous Okrug are considered part of the Tyumen Region, but the association has not been legally registered), a multi-stage election system operates. 40 days before the voting day, the head of the Tyumen region must offer the president at least five candidates for the post of governor of the Yamal-Nenets Autonomous District. Vladimir Putin will choose three of them and submit them to the Yamal Legislative Assembly, which will be selected by the head of the region on a single day of voting.
Earlier today, Vladimir Putin appointed the Tyumen oblast head Tyumen City Governor Alexander Moore to replace the head of the Ministry of Construction, Vladimir Yakushev. Also, the Governor of the Amur Region, Alexander Kozlov, went to work in the White House, and the appointment to the region is expected in the near future. The most likely candidate for this post is called deputy chairman of the president in the Far Eastern Federal District Vladimir Solodov (see "Kommersant" on May 25).
On May 28, the heads of the Magadan Region and Yakutia Vladimir Pecheny and Yegor Borisov resigned voluntarily. Vladimir Putin appointed the Magadan governor of the mayor of Nizhny Tagil Sergei Nosov, and the head of Yakutia, the mayor of Yakutsk, Aisen Nikolayev.


How to make a 3d pdf out of solidworks - Minecraft 1 6 2 installer download
PARTcommunity is a library for 2D & 3D CAD models of supplier and standard parts. Is a leading provider of microcontroller mixed- signal, lower total system cost , providing low- risk product development, Illustrator resources, analog , faster time to market for thousands of diverse customer applications om free software to Adobe Photoshop , Flash- IP solutions, we have the tutorials guidance you need to nail that design. I’ ve gathered a list of my favorite four new features. Mostly because it seems like not everyone understands what it’ s all about.
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There are some great new features in SOLIDWORKS Inspection I am excited to get my hands on the final release. The PARTcommunity CAD download portal is an online library for 2D & 3D CAD models of supplier- and standard parts for all CAD formats. Microchip Technology Inc.
Jul 01, · Hi everybody I work at a company in a transition between two programs. At the moment we are generating every. To make this easier.
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SolidWorks SolidWorks is a 3D solid modeling package which allows users to develop full solid models in a simulated environment for both design and analysis. Aug 22, · Free Download 3D PDF Converter 4. 0 - A professional software utility that enables you to effortlessly convert 3D objects and CAD data to PDF nvert native CAD data to 3D PDF. Check out Tetra 4D and start your free trial today. We are the source of the 3D PDF converter.
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Enhance your SOLIDWORKS skill set and learn at your own pace. View expansive video library of SOLIDWORKS Demos, created by GoEngineer product experts. I put together a list of questions that seem to get asked fairly often, along with their answers, so here it is ( they' re in no particular order).
The tracks work well on their own, but you can also add different sounds, loop beats, and play over other artists songs to make them more intricate. SolidWorks Bible [ Matt Lombard] on.


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The new Audi A6 Saloon has earned its first award since its launch. The flagship Audi A6 was awarded ‘Best Executive Saloon’ by the panel of Auto Express judges which marks the first award for the new generation model.
Graham Hope, Acting Editor of Auto Express said “the new Audi A6 has wasted no time in demonstrating its abilities, having seen off a whole host of talented and desirable rivals to secure class honours in this competitive sector. The car’s stunning cabin, excellent engines and sharp dynamics set a benchmark for other to beat.”
There are a choice of four efficient engines offered one petrol and three diesel. The Audi A6 2.0 TDI (177PS) manual is the most efficient derivative achieving 0-62mph in 8.7 second and capable of a top speed of142mph. The Audi A6 2.0 TDI emits just 129g/km CO2 emissions. Economy and emissions are big issues at the moment and Audi has taken steps to ensure the environmental credentials of the Audi A6 are up with the best.
Prices for the Audi A6 Saloon start from £30,145 OTR for the 2.0 TDI 177PS SE model and rise to £41,640 for the range-topping 3.0 TFSI 300PS S line with quattro all-wheel drive.


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Extracorporeal membrane oxygenation (ECMO) is a modified form of cardiopulmonary bypass that allows short-term support for potentially reversible severe acute respiratory and/or cardiac failure in critically ill adults and children. There is increasing interest in veno-venous (VV) ECMO for severe acute respiratory failure in adults. The National Institute for Health and Clinical Excellence has recently updated its interventional procedure guidance, which summarises available data on efficacy and safety of this procedure and provides guidance for clinicians wishing to undertake VV ECMO. The authors summarise and reflect on the guidelines and discuss some recent developments in technology and clinical practice of VV ECMO.
- Extracorporeal membrane oxygenation
- extracorporeal circulation
- respiratory insufficiency
- acute respiratory distress syndrome
- intensive care
- cardiogenic shock
- cardiac surgery
- lung injury
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If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Competing interests None.
Provenance and peer review Commissioned; internally peer reviewed.


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In Gerritsen's "Thief of Hearts, " a gentleman bandit and a female cat burglar catch each other in more ways than one. Their distrust of each other is only as strong as their desire. In Erickson's "Shadow of the Sun, " a man entertains his best friend's girl and falls hard for her.
Similar books by other authors
Used availability for Tess Gerritsen's Something to Hide
September 1999 : UK Mass Market Paperback


In this interesting post from 2015—getting a viral second wind—Alex Danco offers a model to understand how the "middle ground" of interest in things is fading. That's the normal distribution, the traditional bell curve that suggests the best place to make your business is at a middle optimum of scale and interest, like so:
Instead, these days, you're either interested or not. To make a go of something, you have to nail either scale or interest (i.e. cheap vs quality):
It strikes me that what Danco's defined here is a flip (on the horizontal axis) of the classic early-2000s theory about how the web would allow creators to make money like never before, the long tail.
The idea was that the internet dissolved gatekeepers, democratized the marketplace, and allowed consumer internet to roam over (and buy) a "long tail" of options that was revealed to them by new technology.
And it did, for some. Mostly, though, the long tail ended up as aggregated social media content. The bonds of content, creator and consumer, far from being remade by the internet, were also dissolved by them. Instead of a long tail, we have a green goo of nanocontent which wants to become as vast as possible, with a couple of big corporations making all the money.
I don't have a clever point to make, I just think it's interesting that social media not only submerged the long tail but made us forget it ever existed—and now it's going to be rediscovered from other viewpoints over and over again, each time in increasingly imprecise and alarmed terms. Read the rest