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Dr. Mountz is a Professor of Radiology, Director of NeuroNuclear Medicine, and Chief of The Division of Nuclear Medicine, University of Pittsburgh Medical Center Health System, Pittsburgh, PA.
Most combined positron emission tomography/computed tomography (PET/CT) scanners are optimized for applications in body oncology imaging and are more limited for use in neuroimaging examinations than dedicated neuro-PET or neuro-CT equipment. With proper protocols, however, most PET/CT scanners can provide excellent PET and CT brain scans if the acquisition and reconstruction parameters are appropriately selected. A previous article in a supplement to Applied Radiology addressed the type of radiopharmaceuticals used in central nervous system (CNS) applications and the use of PET/CT for the evaluation of dementia. 1 This article will highlight predominant applications of neuro PET/CT in epilepsy and brain tumors.
Regional cerebral perfusion evaluation in patients with epilepsy has proven to be of significant clinical value for epileptogenic focus identification. The underlying pathophysiology for using regional cerebral perfusion tracers in epilepsy is based on the clinical observation that was first reported by Sir Victor Horsley more than 100 years ago. He described (by direct observation of the brain during surgery) an increase in cortical blood flow in the area of seizure discharge. Therefore, the most valuable use of single-photon-emission CT (SPECT) regional cerebral blood flow (rCBF) tracers is to localize the epileptogenic focus during the ictal state.
Epileptogenic focus localization using ictal rCBF SPECT
In order to perform these studies, the rCBF tracer must be readily available at the patient's bedside, allowing for rapid injection by a trained technologist or other personnel immediately at the time of seizure onset. The ictal injection should be performed in a rapid bolus fashion such that the entire tracer is injected before the seizure abates. The patient is then stabilized and transferred to the SPECT scanner to receive a brain SPECT scan, which will indicate the regional cerebral perfusion at the time of ictus. This method is feasible, since the tracer is irreversibly trapped in the epileptogenic hyperemic region at the time of seizure. During the period between injection and scan, there is essentially no redistribution. The subsequent scan (albeit possibly several hours after the injection) still shows hyperemia in the region of the epileptogenic focus. Several articles characterize the brain propagation patterns of the epileptogenic electrocortical dis- charge and resultant rCBF hyperemia to allow for more accurate localization of the epileptogenic focus in cases where ≥2 cortical areas are seen to be hyperemic on the brain SPECT scan. 2-
Figure 1 illustrates the value of ictal SPECT in a 9-year-old right-handed boy who had a 7-year history of intractable seizures. The patient averaged 20 to 30 seizures a day. The seizures were characterized by an aura of tingling in the mouth, followed by simultaneous extension of the legs and flexion of the right upper extremities with nonpurposeful movements of both legs lasting 20 seconds. Multiple video electroencephalography (EEG) monitoring studies showed stereotypical seizures with no ictal scalp localization. Interictal activity revealed occasional sharp discharges involving the right frontal central parietal regions. Several CT and magnetic resonance imaging (MRI) studies were normal. A technetium (Tc)-99m hexamethyl propyleneamine oxime (HMPAO) brain SPECT scan was performed 2 hours after tracer injection (Figure 1). The tracer was injected at the patient's bedside 3 seconds after the seizure's onset (the seizure lasted approximately 25 seconds). The ictal rCBF brain SPECT scan showed a focal area of intense uptake in the right frontal lobe.
The result of the ictal brain SPECT scan was subsequently coregistered with the MRI scan, and the placement of subdural grid electrodes confirmed the epileptogenic focus location. Based on the fusion image, the anatomic location was determined, the epileptogenic focus was surgically excised, and the patient was rendered seizure-free.
It has been shown that well-performed ictal SPECT in patients with extratemporal lobe epilepsy has superior localization capability as compared with interictal fluorine-18 (F-18) 2-fluoro-2-deoxy-D-glucose (FDG) PET. However, if ictal SPECT is not available, identification of the epileptogenic focus during the interictal state using F-18 FDG-PET can provide localization in some cases. In cases of suspected temporal lobe epilepsy, the preferred diagnostic imaging protocol is to perform interictal F-18 FDG-PET in addition to ictal and interictal SPECT.
F-18 FDG-PET brain assessment in the interictal state
Presurgical evaluation and the surgical treatment of nonlesional neocortical epilepsy is one of the most challenging areas in epilepsy surgery. FDG-PET shows hypometabolism in a majority of patients with nonlesional temporal lobe epilepsy (TLE), even in the absence of hippocampal atrophy. Interictal FDG-PET and ictal SPECT were found to be useful as complementary and, sometimes, independent modalities. 7 One area in which F-18 FDG may play a role beyond localization is to define the surgical margins since the extent of resection of the region of hypometabolism on the preoperative FDG-PET is predictive of outcome following surgery for non-lesional TLE. 8
Figure 2 illustrates concordance between abnormalities on MRI and F-18 FDG-PET in a 16-year-old boy with temporal lobe epilepsy and hippocampal sclerosis of the right mesial temporal lobe on MRI. The MRI shows abnormal high signal intensity in the right hippocampal region. The FDG-PET shows a corresponding area of focal reduction of F-18 FDG uptake in the right hippocampal region. After undergoing right temporal lobectomy, the patient was rendered seizure-free.
The localization of epileptic foci in patients who have intractable extratemporal epilepsy remains a challenge in the presurgical evaluation. The most common underlying pathology in extratemporal neocortical epilepsy is microscopic cortical dysplasia, which cannot be readily detected by current MRI techniques. 9 FDG-PET may not be as valuable in the evaluation of patients with extra-temporal seizures, such as frontal lobe epilepsy, because of limited sensitivity. 10
Figure 3 illustrates the significant advantage of ictal SPECT as compared with interictal F-18 FDG-PET. The patient is a 42-year-old woman who experienced 1 to 2 brief seizures per day. Seizure activity was thought to arise from the frontal lobe regions, but video-EEG monitoring was nonlocalizing. The MRI scan was normal. The F-18 FDG-PET brain scan was nonlocalizing. An ictal brain SPECT scan showed significant hyperemia in the right frontal lobe. Figure 3 shows correlative images of the significant hyperemia on ictal SPECT as compared with nonspecific reduction on FDG-PET. This example illustrates the relative nonspecificity of mild areas of reduction on an FDG-PET brain scan in cases of frontal lobe epilepsy. In these cases, an ictal brain SPECT scan can provide greater accuracy in diagnosis.
Figure 4 illustrates epileptogenic region localization in a 2-year-old girl with intractable partial epilepsy and developmental delay. The EEG showed frequent and focal discharges from the right frontoparietal region. In this case, the F-18 FDG-PET scan localized the epileptogenic region suitable for grid placement and invasive intracranial EEG monitoring.
Interictal FDG-PET studies have limited usefulness in the presence of multiple hypometabolic regions in patients with multifocal brain syndromes, such as in children with tuberous sclerosis. Such children with multifocal lesions represent a special challenge during presurgical evaluation. The goal of functional imaging in these cases is to identify the epileptogenic lesions and to differentiate them from the nonepileptogenic ones. In this context, ictal rCBF SPECT may have useful clinical applications but may be technically challenging when seizures are short, as is particularly common in frontal lobe epilepsy and in children who have infantile spasms that are associated with multifocal cortical dysplasia. 11 Figure 5 shows such a case in a 1-year-old boy with tuberous sclerosis. Anatomically, there were several lesions that were abnormal on the CT portion of the PET/ CT scan. These areas also showed reduced FDG uptake on PET. Ictal SPECT (not shown) was able to identify the dominant area of presumed epileptogenesis associated with a large tuber in the right frontal lobe.
The role of PET neuroimaging in brain tumor
Since the introduction of CT in the mid-1970s and MRI in the early 1980s, neuroimaging has become extremely important in the diagnosis of primary and metastatic brain tumors. These various neuroradiologic imaging techniques have also found new and important applications in assisting with biopsy localization, monitoring the effects of therapy, and differentiating recurrence from radiation effect or necrosis. 12 The identification of viable tumor after therapy is a significant clinical problem, since the distinction between necrosis and residual or recurrent viable tumor cannot be accurately evaluated by either CT or MRI. 13-15 Functional imaging can distinguish cerebral necrosis from viable brain tumor and determine tumor grade. 16-18 More recently, FDG-PET imaging has been shown to be of value in the prediction of tumor metabolic response to temozolomide versus temozolomide plus radiotherapy in recurrent high-grade gliomas. 19 Therefore, the monitoring of therapeutic response by PET imaging is now used to provide an early assessment of therapy efficacy and to help the oncologist optimize the therapeutic management of brain tumors.
F-18 FDG-PET-- The use of F-18 FDG-PET has led to a more widespread capability in allowing the evaluation of cerebral neoplasms as well as other diseases of the brain that were previously imaged using SPECT radiopharmaceuticals. 20 In addition, due to the relatively long half-life of F-18 (109 minutes), it can be transported regionally (within approximately 2 to 4 hours travel time from a cyclotron production facility), enabling a centrally located production facility to supply several camera sites. Figure 6 shows a PET scan with abnormal uptake of F-18 FDG in a patient with a recurrent high-grade brain tumor involving the anterior frontal lobe after 8 years of remission.
F-18-fluoro-3'-deoxy-3'-L-fluoro-thymidine PET for the evaluation of viable brain tumor-- F-18-fluoro-3-deoxy-3-L-fluorothymidine (F-18 FLT) has recently been developed as a proliferation tracer. Imaging and measurement of proliferation with PET can provide a noninvasive staging tool and a means to monitor the response to anticancer treatment. 21 In contrast to quiescent cells, proliferating cells synthesize deoxyribonucleic acid (DNA) during the S phase of the cell cycle. F-18-fluoro-3-deoxy-3-L-fluorothymidine is taken up by the cell via both passive diffusion and facilitated transport by Na + -dependent carriers. Subsequently, F-18 FLT is phosphorylated by thymidine kinase 1 (TK1) into F-18 FLT-monophosphate, after which it is trapped in the cell (Figure 7). Thymidine kinase 1 is a principal enzyme in the salvage pathway of DNA synthesis. The enzymatic activity of TK1 is virtually absent in quiescent cells, but in proliferating cells it reaches a maximum in the late G1 and S phases of the cell cycle. 22 Therefore, the phosphorylation by TK1 forms the basis of F-18 FLT as a proliferation tracer.
F-18-fluoro-3'-deoxy-3'-L-fluorothymidine has been used to indicate tumor proliferation in both preclinical and clinical studies. 23,24 The imaging of brain tumor proliferative activity has been performed using semiquantitative measures of standard uptake values. [F-18]-fluoro-3'-deoxy-3'-L-fluorothymidine imaging can be correlated with stereotactic biopsies representing the Ki-67 proliferation index. Recurrent or residual viable tumor showed an increased quantitative FLT utilization and can provide a useful index to separate residual or recurrent viable tumor from radiation or chemotherapy necrosis. [F-18]-fluoro-3'-deoxy-3'-L-fluorothymidine is more specific for detection of viable tumor proliferation, since the background activity in normal brain is low (Figure 8), unlike F-18, which has a high normal brain background. Figure 9 shows tissue histology and staining with MIB-1 to allow correlation between F-18 FLT uptake and the proliferation index Ki-67.
PET imaging of radiolabeled amino acids for brain tumor assessment-- Radiolabeled amino acids are becoming increasingly useful as tracers for the delineation of tumors, particularly brain neoplasms. Unlike FDG, the radiolabeled amino acids are not taken up by normal cortical gray matter and provide a greater target-to-background contrast, thus allowing better characterization and differentiation of the tumor from the normal cortical gray matter. The most commonly used PET amino acid radiotracer to date has been l-[methyl-C-11] methionine (C-11 MET). However, due to the 20-minute half-life of C-11-labeled tracers that requires the need for in-house cy-clotron production, amino acids labeled with F-18 are of particular interest because of their advantageously longer half-life and possibility for commercial availability. Recently, improved labeling procedures have overcome some limitations of tracer synthesis for routine PET application. The tracer 3,4-dihy-droxy-6-F-18-fluoro-L-phenylalanine ( 18 F-FDOPA) is a new amino acid, which has been recently evaluated. 25 Both high-grade and low-grade tumors are well visualized with 18 F-FDOPA. The sensitivity for identifying tumors was substantially higher with 18 F-FDOPA PET than with 18 F-FDG-PET at comparable specificities, especially for the assessment of low-grade tumors. Therefore, 18 F-FDOPA PET may prove especially useful for imaging of recurrent low-grade tumors and for distinguishing tumor recurrence from radiation necrosis.
By developing ictal and interictal SPECT capability in addition to F-18 FDG-PET, the radiologist can better provide the neurosurgeon with more definite presurgical location of epileptogenic foci. With the advancement of new therapies for the treatment of brain tumor, it is important to provide more accurate assessment of tumor grade on initial diagnosis and better diagnosis of recurrent viable tumor versus chemoradiation necrosis on early follow-up PET scans after therapy for both low- and high-grade brain tumors.Back To Top
PET/CT neuroimaging applications for epilepsy and cerebral neoplasm. Appl Radiol.


This ghost-face-animal from Kalamazoo is charged with murder after authorities say his 2-week-old son was repeatedly shaken and later died.
The Kalamazoo Gazette reports 22-year-old Glenn Ross was arraigned by video Thursday before a Kalamazoo County District Court judge. He cried like a bitch through much of the hearing and asked the court to appoint a lawyer for him.
Ross, who told the court he lives with his parents, was ordered held on $100,000 bond. He’s due back in court March 7.
Investigators said in a statement they got a 911 call midday Tuesday reporting the baby wasn’t breathing. The infant was taken to an area hospital, where he died Wednesday night. No wonder why their numbers are plummeting.


The construction of part of the phase1 of Tabriz metro is nearing completion, and with the expected arrival of the wagons, the metro will become operational.
Underground Politics in Tehran - Since its launch 12 years ago, Tehran's underground rail network has proved a success, alleviating traffic congestion and pollution in this city of 13 million. The prestige attached to this feat of construction has resulted in a political power-struggle for control over it. -Babak Kermani
... Payvand News - 12/28/10 ... --


|Model||:||Redmi Pro 64GB|
|Launch Date (Global)||:||27-07-2016|
|Colors||:||Gold, Silver, Dark Grey|
|Product Name||:||Redmi Pro 64GB|
|Screen Size (In Inches)||:||5.5|
|Display Technology||:||Full HD OLED Capacitive touch display|
|Screen Resolution (In Pixels)||:||1080 x 1920|
|Pixel Density (Ppi)||:||401|
|Scratch Resistant Glass||:||N/A|
|Rear Camera Megapixel||:||13 + 5 MP|
|Front Camera Megapixel||:||5|
|Front Facing Camera||:||Yes|
|Aperture (F Stops)||:||N/A|
|Laser Focus Af||:||N/A|
|Battery Capacity (Mah)||:||4050|
|Removal Battery (Yes/no)||:||N/A|
|G (Gravity) Sensor||:||N/A|
|Finger Print Sensor||:||Yes|
|Dust Proof And Water Resistant||:||No|
|Cpu||:||MediaTek Helio X25|
|Cpu Speed||:||2.5 GHz|
|Weight (In Grams)||:||177|
|Removable Storage (Yes Or No)||:||Yes|
|Removable Storage (Maximum)||:||N/A|
MSME DAY 2021 Deals
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Redmi Pro 64GB was launched in July 2016 & runs on Android 6.0 OS. The Smartphone is available in three color options i.e. Gold, Silver, Dark Grey & has a built in fingerprint sensor as the primary security feature, along with the host of connectivity options in terms of 3G, 4G, GPS, Wifi Bluetooth capabilities. The phone is available with 64 GB of internal storage.
The Smartphone is powered by 2.5 GHz Deca core MediaTek Helio X25 Processor. A 3 GB of RAM ensures phone runs smoothly even the most memory intensive applications & still shows no signs of lag. 64 GB of internal storage can be expanded via a microSD card.
The Phone comes with a inch screen with Full HD OLED Capacitive touch display having a resolution of 1080 x 1920 at 401 ppi.
Redmi Pro 64GB boasts of dual primary camera of 13 + 5 MP megapixel and 5 megapixel front Camera.
OnePlus 7 and 7T series of phones have started receiving the latest OxygenOS 11 Open Beta 5 update. This is a global update, which according to the company is the final public beta release based...
Poco M3 Pro has officially launched in India and is the company’s first 5G phone that is powered by a Dimensity 700 5G processor. The phone was announced globally back in May and the company is now...
The Poco M3 Pro is barely a day away from from being launched in India. The phone will be unveiled tomorrow, with the company also set to reveal its pricing at the virtual launch event....
Honor is expected to stage its grand global comeback with the Honor 50 series phones in the coming weeks. The series will reportedly include three phones, namely the Honor 50, Honor 50 Pro, and Honor 50...
Digit caters to the largest community of tech buyers, users and enthusiasts in India. The all new Digit in continues the legacy of Thinkdigit.com as one of the largest portals in India committed to technology users and buyers. Digit is also one of the most trusted names when it comes to technology reviews and buying advice and is home to the Digit Test Lab, India's most proficient center for testing and reviewing technology products.
We are about leadership — the 9.9 kind Building a leading media company out of India. And, grooming new leaders for this promising industry


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Changing faces of our veterans
More Canadians served in the First and Second World Wars than in all the other conflicts our country has been involved in, combined. We should not forget that. At the same time, these two wars are receding into the past, as is the more recent Korean War. The number of surviving veterans from these three wars is diminishing.
tap here to see other videos from our team.
We need to stop thinking of our living veterans as aging senior citizens. Increasingly, they will be younger people who served in peacemaking and peacekeeping missions like the Balkans in the 1990s and early 2000s, Rwanda, Somalia and, more recently, Afghanistan. Our youngest Afghanistan veterans are in their early 20s.
If we are going to keep Remembrance Day relevant, we must widen our focus and also remember those who have served, and died, in more recent conflicts.
John Fleming, Edmonton
Strip him of rights as judge, lawyer
Re: “ Judge’s conduct in trial to be reviewed ,” Nov. 10
It’s hard to fathom that in 2015, a judge can tell a courtroom that “a woman can’t be raped against her will” and ask the victim, “why couldn’t you keep your knees closed?” Former Calgary provincial court Judge Robin Camp, now sitting in Federal Court, should immediately lose his professional designation as a judge and a lawyer. His behaviour was disgraceful, and his actions will no doubt stop future rape and abuse victims from stepping forward.
How would Camp react if it were his daughter or wife who was raped?
Lynn Vogelesang, Edmonton
Iveson’s social media version of Nero
Re: “ Tax hike will spark public outrage ,” David Staples, Nov. 4
Mayor Don Iveson says he’s running a lean organization. I could not disagree more.
I see city employees asleep in their vehicles in our neighbourhood. At the department of sustainable development, staff can barely rouse themselves to serve me. During a 20-minute wait, with no one else in the waiting area, I witnessed two receptionists discussing their much-needed break — this at 8:30 a.m. Then there’s a snow-removal process that is completely ineffectual, although I am somewhat hopeful thanks to the appointment of a new department head.
Iveson recently thought he was clever when he said of the 102nd Avenue Bridge over Groat Road: “Is it fair to say the results of the erection procedure were rather limp in this case? … I couldn’t resist.” To me, this speaks to an immature brain that focuses on the wrong end of issues. Entrepreneurs in High Street probably have a different perspective and would fail to see the humour in the mayor’s comment as they see their businesses suffer.
This mayor does not have a vision of what the city should become, where it is headed or how to finance that journey. His inexperience and immaturity are glaringly obvious.
Connie Shelley, Edmonton

domain: news


C.A 1510 Indoor air quality tester
Equipped with a large two-colour backlit display, the C.A 1510 simultaneously displays the CO2 level, the temperature and the humidity.
CO2, temperature and humidity logger (up to 1 million measurements)
Compact and stand-alone: for fixed or portable use
User-friendly: thanks to the comfort indicators based on the CO2 level and hygrothermal criteria
Accurate: complies with the latest standards concerning air quality monitoring
Low gas consumption for verification with its in-situ calibration kit.
CA 1510 allows continuous measurement of the level of CO2 in the ambient air, which provides an indication of the need to ventilate the room in order to renew the air and avoid being in an overly confined environment that can favour exposure to the virus and thus the risk of contamination.
|Best Temperature Measurement Accuracy||±0.5 (-10°C to 60°C)|
|Temperature Measurement Resolution||0.1°C/0.1°F|
|Maximum Humidity Measurement||95%RH|
|Best Humidity Measurement Accuracy||±2 %RH|
|Humidity Measurement Resolution||0.1%RH|
|Carbon Dioxide Resolution||1ppm|
|Best Carbon Dioxide Accuracy||±3%|
|Battery Life||15 days|
|Minimum Operating Temperature||-10°C|
|Dimensions||125 x 65.5 x 32mm|
|Maximum Carbon Dioxide Level||5000ppm|
|Minimum Carbon Dioxide Level||0ppm|
|Display Type||Backlit LCD|
|Model Number p||CA1510|
|Maximum Operating Temperature||60°C|


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Langley, Eric Rice, Starman Mike Gaines, and Annika O’Brien talk Robot Combat League, Star Trek Wiki Tiff, Ron Jeremy in hospital, Robocop News and more!
Langley, Annika “Skywalker” O’Brien, Eric Rice, and Starman Michael Gaines are back with news of lip syncing divas, bad Florida stories, Robocop news, and more on this week’s Robot Underpants.
End Track: Borderline — The Showoffs
Langley, Eric and Starman Mike have something to say about the recent gun control laws, bad movies, ROBOCOP NEWS, Star Wars News, and more!
Langley is back in LA with Annika, joined as usual by Eric Rice and Starman Mike to discuss Qualcomm, Alex Jones, Linux rifles, and mollusks.
Recorded live in Hollywood California.. Sorta. Langley is in the same room with Jason Mewes… no wait.. that’s Annika Skywalker dressed up like Jay. Eric Rice and Starman Mike join to talk about the new year, Denny’s Hobbit menu, Twin Peaks news and more!
“Jungle Love” by Morris Day & the TIME Covered by 20 LB SLEDGE


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HUDSON -- Make a collage from recycled discs at the Rodgers Memorial Library on Thursday at 6:30 p.m. Collages can be two- or three-dimensional and can be used as ornaments, wall hangings or parts of a scrapbooking project. The library hosts a Paper Techniques Workshop with a different hands-on craft project on the first Thursday of each month at 6:30. Check the library website or call the library for info on each month's project. Pre-registration is required, go to rodgerslibrary.org or call the library at 603-886-6030.
The Rodgers Memorial Library is hosting a new film series, second Thursdays at 6:30. Catch films you may have missed. Snacks will be served. The Jan.10, film is a comedy about a middle-aged couple who meet with an unconventional therapist to try to put some life back in their marriage. Call 886-6030 for details.

domain: library


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An interview I did recently.
Eddie: Why knitting?
Donna: I particularly like the portability, and the ability to explore so much...
This is a blog post from The Art of Non-Conformity with my personal notes added.
. This is how you do it. First, sit yourself down wherever...

domain: artistic


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these don't really make much sense
- •Day 1: it's raining 5 panels and pocket Ts
- •Day 2: the lava is still freezing. global cooling is real.
- •Day 3: it's like raiiiiiiiiiin on you wedding day
- •Day 4: it's flooding chocolate milk. I'm not even that mad.
- •Day 5: the sky is falling

domain: geography


Norwich Georgian house conversion plans disappoint expert
A council conservation officer concerned at a bid to turn a Grade II-listed house in Norwich into an £8.5m writers' centre has criticised planners for failing to heed expert advice.
Writers' Centre Norwich's plans for Gladstone House, in St Giles Street, go before councillors on Thursday.
City council planners are recommending the plan is approved.
The conservation officer says planners have gone against the advice of experts in backing the plans.
Among those to oppose the plans for the Georgian building are English Heritage, while the Georgian Group has called for changes to the plans.
Norwich City Council has said it can not comment in the run-up to the meeting.
Conservation officer Chloe Canning-Trigg has written two reports to the council about the plans.
In the first she says: "The proposed alterations would cause substantial harm to the listed building and its setting."
She says there is not enough justification for the removal of a 1790s staircase and there needs to be a proper acoustic survey of the building and the need for sound insulation.
Ms Canning-Trigg says if these and other concerns raised by Georgian Group and other organisations are not addressed the application "should be withdrawn or refused".
In a second report, submitted after the city council had decided to recommend the scheme's approval, Ms Canning-Trigg says the recommendation "usurped" her consultation advice and was "contrary to the advice of internal and external consultees".
She says she was "disappointed" that concerns raised had not been addressed.
In a report to the council, officers say the scheme would benefit the cultural status of the city.
The report says the plans do not amount to "substantial harm" to a listed building.
If the plans are approved, at a meeting of the council's planning committee on 6 March, the centre could open to the public by autumn 2016.


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Exploring the Excitement of PG Slot Demos: Try Before You Play for Real Money
Slot games have been a staple in casinos for many years, and with the rise of online gambling, they have become even more popular. One of the most exciting developments in the world of online slots is the availability of demo games, which allow players to try out a game before they play for real money. PG Slot demos are a great way to explore the excitement of slot games and get a feel for them before risking any of your hard-earned cash.
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By playing PG Slot demos, players can familiarize themselves with the game’s rules, paytable, and bonus features without any risk. This allows them to make an informed decision about whether they want to invest their time and money in a particular slot game.
Why Should You Try PG Slot Demos?
There are several reasons why players should try PG Slot demos before they play for real money. Firstly, playing demos allows players to explore a wide variety of slot games without having to make a financial commitment. This is especially beneficial for new players who are still learning about the different types of slot games and their features.
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PG Slot demos are widely available at online casinos that offer slot games. Many casinos allow players to play demos without even having to create an account, making them easily accessible to anyone who wants to try them out.
Additionally, there are numerous websites and online platforms that offer free slot demos for players to enjoy. These platforms often have a wide variety of demos from different game developers, allowing players to explore a diverse range of slot games.
Playing PG Slot demos can be a great way to learn about different slot games, hone your skills, and have an enjoyable gaming experience without any financial risk. Whether you are new to slot games or a seasoned player, trying out demos is definitely worth your time.
Q: Are PG Slot demos the same as real-money games?
A: PG Slot demos feature the same gameplay and features as real-money games, but they do not require any financial commitment. This means that players can enjoy the full gaming experience without risking any money.
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A: No, PG Slot demos are purely for entertainment purposes and do not offer any real-money rewards. To win real money, players need to play the game for real money at an online casino.
Q: Do I need to download anything to play PG Slot demos?
A: No, most PG Slot demos are available to play directly in your web browser, with no download required. This makes them easily accessible to anyone with an internet connection.
Q: Can I play PG Slot demos on my mobile device?
A: Yes, many online casinos and platforms offer mobile-friendly PG Slot demos, allowing players to enjoy the games on their smartphones and tablets.
In conclusion, PG Slot demos are a fantastic way for players to explore the excitement of slot games without risking any of their own money. Whether you are new to slot games or a seasoned player, trying out demos can help you find new games to enjoy and potentially win big on. So why not give them a try and see what all the fuss is about?

domain: game


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MAKE TIME FOR YOU; YOU'RE WORTH IT.
I have a deep desire to empower people through achieving a harmonious mental, emotional, physical and spiritual well-being. Every body is unique, and I take pride in working with clients to create a customized plan that addresses their specific needs.
It's an honor to be a part of your journey toward wellness, and I strive to elevate your experience by being authentic and present. Schedule a session today to start your journey toward transformation.
The Sophisticated Hippie
Book an Appointment
Welcome to The Sophisticated Hippie, where you can embark on a transformative journey towards wellness and healing. I'm a passionate practitioner who cares deeply about helping you lead a fulfilling life. My approach is centered on the belief that wellness is a personal journey, and I'm here to walk alongside you as we explore the path towards physical, mental and emotional health. If you're ready to make a positive change in your life, let's work together and transform your life for the better.
“Every human being is the author of his own health or disease”
"I can’t say enough great things about Aubrey!! She actually listens to what you want and need. I’m pretty sensitive so she applies the amount of pressure I can handle but she also stretches me and makes sure she gets the areas I’m having trouble with. I highly recommend Aubrey, you will not be disappointed!!"

domain: psychology


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Bhubaneswar: Taking prompt action, IG of Prisons and Correctional Services Himashu Lal transferred three jail superintendents after few videos showing some prisoners at Jharpada jail here smoking ganja went viral.
Bhubaneswar Special Jail Superintendent Dheerendra Nath Barik was transferred to Balangir District Jail while Balangir District Jail Superitendent Urmila Minj transferred to Puri District Jail. Saroj Biswal, Superintendent of Puri District Jail has been transferred to Bhubaneswar Special Jail.
Earlier in the day, few video footages from the Jharpada jail surfaced on social media.
In one of the viral videos, once can see one group of inmates at the Jharpada jail indulged in merrymaking by singing songs and playing musical instruments and another group smoking ganja in a chillum (a traditional smoking pipe made of clay). In another video, the prisoners were found dancing inside the jail.

domain: law


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BDANR, in Fiction. 08/11/2017 (Updated: 11/11/2017)
There is No Forever is a story about three friends living on the infamous James Street, the gayborhood of the city. Playboys, abandonment, violence, each manage life’s unexpected obstacles that bring them together while simultaneously ripping them apart.
lilansui, in Fiction. 08/22/2018 (Updated: 03/18/2019)
coming of age
Portento is a town hiding a huge secret. A secret the Morgan Family has worked for generations to keep. Outsiders are not allowed in without the Portento Council's approval. Until the Takeda Family moves in unnoticed.
Milan Takeda has been sick all his life. Rory Morgan just turned eighteen and is looking forward to taking on his birthright. Then he meets Milan, and his world changes.
An unfinished and cursed piano composition travels through three centuries, mysteriously intertwining the lives of two great artists. One was the brilliant composer of the work, the other became its celebrated performer.
The story starts with the fortunate discovery of a manuscript in the over-cover of the original score. From the mid-19th century it concludes at the dawn of the third millennium.
Dayne Mora, in Fiction. 12/20/2015 (Updated: 07/25/2016)
Cory, 18 year-old walking Texas stereotype who swings both ways, comes to Virgina Tech to play football and hopefully be less of a closet case. There he finds a sophomore wide-receiver who likes to bite, a pretty boy pre-med with a talent for name calling, and a grad student with a big...chip on his shoulder. (Formerly "Efrain and Cory")
C. Henderson, in Fiction. 01/20/2022 (Updated: 02/21/2022)
When a brutal hit-and-run accident ends the life of his son, David Andrews is left picking up the shattered pieces of what remains. As his marriage, career, and friendships unravel, he becomes fixated on finding the other driver and taking revenge.
Kat Bryce is a rookie detective partnered up with Jack Miller, a veteran officer with his own unique vision of justice. Despite their moral differences they quickly reach the same conclusion—something about the Andrews case is sinister. As they scramble to solve the mystery, David begins his own investigation. This father's love knows no bounds, but how far will he go to uncover the truth?


SO, JUST WHAT SHADE OF GREEN, is your envy?😲😃😊😉 Congratulations to Peter Cushing / Star Wars fan, Korrathrace over on Deskgram, who recently took ownership of this fine signed, colour frame portrait of Peter as Grand Moff Tarkin from the 1977 'Star Wars'.... 'BTW this is mine now uhhhhhhhhhh . . .' says she 😉
PROBABLY, PERSONALLY ONE OF MY ALL TIME favorite photographs of #PeterCushing. Taken on the set of the 1977 'STAR WARS', by continuity supervisor, Ann Skinner, Cushing between takes with Dave Prowse and Don Henderson. Prowse worked with Cushing on his last Frankenstein film for director Terence Fisher and Hammer films, Frankenstein and the Monster from Hell and Henderson worked with Cushing on Tyburn films, 'The Ghoul'
OUR PCASUK feature on 'THE GHOUL' HERE!


Scientists from Tomsk Polytechnic University have developed a device for the rapid analysis of liquids on the content of hazardous substances - such as heavy metals. Polytechnicers use a method based on polymer optodes - very small plastic matrices that can be made sensitive to specific substances by means of special reagents.
The matrices change color and its intensity depending on the concentration of the substance. The device is mobile, can carry out analysis in situ even at low temperatures, and its cost is many times less than the price of a spectrophotometer - the most used device for chemical analysis.
“The device is based on polymethacrylate sensors - transparent pieces of plastic with thickness of 1 mm and a size of 3x3 mm. The pores of matrices serve as receptacles, where various chemical reactions can undergo. If a matrix is handled with a special reagent it becomes an optode sensitive to a particular substance. We plunge this optode into the water to test it or simply drip a few drops on it, and it changes its color. Hence, there is a required element.
Sergey Muravyov, the scientific supervisor of the project, head of the TPU International Laboratory Advanced Measurements, says: "The more intense the color is, the higher is the concentration of the substance,”
For example, if water contains silver optode turns purple-red. According to the scientist, such a method can detect substances even at very low concentrations in water.
“You dip optode into the water and then load it into the device analyzer. There a special electronic device receives optical signal and converts it into an electric three-channel RGB-signal.
After this signal processing the device outputs the data in digital form on the concentration of the searched substance. The analysis takes place immediately,”
- the project manager says.
This method allows the detection of almost all metals, organic materials and various pharmacological agents in water.
“Our method works with those substances with which interaction leads to color change. Indeed, this is not the whole range of substances. But universal methods do not exist. Today, the most widely used method for chemical analysis is spectrophotometry. A modern spectrophotometer costs about 500 thousand rubles, and it is a bulky stationary device. Our device can achieve the same quality of measurements, but it is compact and can cost about 30 thousand rubles at the market placement,” - he says.
Such a device for rapid analysis is useful for environmental and related services personnel of industrial enterprises. For example, oil companies can use the device for the determination of the tracers in the drilling fluid.
“To date, we have prepared a prototype device, - Sergey Muravyov says. - Now we have set ourselves the task to use this method for a multi-component analysis. The fact is that the reagents that configure optode to a definite substance are sensitive to a few substances.”
Let us add, in 2014 the project research team has received a grant of the Russian Scientific Foundation for up to three years.
The project was funded with the three-year grant of the Russian Scientific Foundation in 2014.
For further information, please contact:
Kristina Nabokova | AlphaGalileo
Litter is present throughout the world’s oceans: 1,220 species affected
27.03.2017 | Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung
International network connects experimental research in European waters
21.03.2017 | Leibniz-Institut für Gewässerökologie und Binnenfischerei (IGB)
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
29.03.2017 | Materials Sciences
29.03.2017 | Physics and Astronomy
29.03.2017 | Earth Sciences


text:
Hi friends, today I would like to introduce a new Chinese classical poem. This poem, written by the former Chinese leader Mr. Mao Ze Dong (1896 to 1976), is called Die2 Lian4 Hua1-Da2 Li3 Shu2 Yi1, which means The Butterfly Loves the Flower-Reply to Mrs Li Shuyi. He wrote it to express how he loved and missed his wife, Ms. Yang Kahui (1901 to 1930) who was killed by their enemies in 1930.
In 1957, one of the best friends of Yang Kaihui's -- Ms. Li Shuyi wrote a poem to remember her husband Liu Zhi Xun, who was Mr. Mao's comrade in arms, and who was also killed by their enemies in 1932. So, Mr. Mao Zedong wrote this poem to reply to her and hers. This poem was published on New Year's Day in 1958.
THE MAIN MEANING OF THE POEMLISTEN-TEXT
Butterfly Loves Flower?reply Ms. Li Shuyi
I lost my lovely wife Yang,
You lost your dear husband Liu.
Their souls flew up to the highest place in the heaven,
They asked Wu Gang what does he have in the Moon Palace?
Wu Gang brought out a drink of flowers of cherry bay.
Lonesome Chang E extended her wide and big sleeves,
She danced for their loyal souls in the 10 thousands mile vast sky.
Suddenly, it was reported that the tigers in the human world had all been caught;
Their happy tears poured down like a cloudburst.
Die2 Lian4 Hua1 ? Da2 Li3 Shu2 Yi1
Wo3 shi1 jiao1 yang2 jun1 shi1 liu3,
Yang2 liu3 qing1 yang2 zhi2 shang4 chong2 xiao1 jiu3.
Wen4 xun4 wu2 gang2 he2 suo3 you3,
Wu2 gang1 peng3 chu1 gui4 hua1 jiu3.
Ji4 mo4 Chang2 e2 shu1 guang3 xiu4,
Wan4 li3 chang2 kong1 jie3 wei4 zhong1 hun2 wu3.
Hu1 bao4 ren2 jian1 ceng2 fu2 hu3,
Lei4 fei1 dun4 zuo4 qing1 pen2 yu3.
die2: butterfly (die2 or hudie2 means butterfly)
lian4:feel attached to, love
da2: reply, answer
wo3: I, me
jiao1 Yang2:lovely Yang. Means my lovely wife. Yang is the family name of Yang Kai Hui, here points the wife of Chairman Mao's.
jun1: you (This is an ancient and literary Chinese word)
Liu: the family name of Liu Zhixun, the husband of Ms. Li Shuyi.
qing1 yang2: flow, fly
chong2 xiao1 jiu3: the highest place/layer of the sky/heaven.
NOTE:In Chinese ancient fable, people thought that the sky has 9 layers, the 9th layer is the highest one.
Wu Gang: A character from Chinese ancient fable, he a celestial being named Wu Gang in the Moon Palace, he had made some mistake. So, he was punished by having to cut down a magical cherry bay tree that was 1650 meters tall. Every time he swung his axe into the trunk of the magical tree, the resulting cut immediately healed and so Wu Gang was doomed never to finish his task.
suo3 you3: have, there is
he2 suo3 you3: what have
peng3 chu1:hold up with both hands, take out
gui4 hua2:the flowers of cherry bay
jiu3: wine, drink
Chang2 E2:A character from Chinese ancient fable. She stole and swallowed her husband’s pill of eternal life, and as a result flew up to the Moon Palace.
guang3 xiu4: wide and big sleeve.
guang3: wide and big
wan4 li3:ten thousand miles
chang2 kong1:vast sky/heaven
zhong1 hun2: loyal soul
ren2 jian1: human being's world, the world
fu2 hu3:overcome the tiger, here means that the enomy has been conquered.
dun4 zuo4:suddenly changed/become something
qing1 pen2 yu3:cloudburst,downpour,drencher
Die2 Lian4 Hua1 ? The Butterfly Loves the Flower is a Ci2 Ge2, which is one of the forms of Chinese classical poetry. Ci1 is a form of classical poetry and conforms to a definite pattern. It was first used in the Tang Dynasty (617 to 907) but was at its most popular in the Song Dynasty (960 to 1279). It was developed based on Tang poetry and could be sung to music. Ci2 Ge2 also has a pattern and is governed by certain rules that determine such features as the number of words in each line, the cadences of different parts and what the foot is at the end of a line… People can fill the pattern with their own content provided the do so according to the rules. So in China, people say “write a poem and fill in the lyrics”. There are over 1000 patterns of Ci2 Ge2 in the Chinese classical field. In modern China, very few young people use this form, but there are still many elder people, researchers, and students who major in Chinese classical language and literature, who use it very well.
Mr. Mao Zedong was just a great poet who used the ancient poetry patterns to write. He has left 37 famous classical poems to the world. If you are interested, I will to do my best to introduce some of them to you later.
If you have any questions, comments, advices or suggestions, please write to email@example.com. You are welcomed.
Write on Aug 23,2004
Edited and Recorded on Sat., Aug 26, 2005
Mike Corrected It On Mon., Sep 12,2005


Time spent online is often productive and well spent but for some, a compulsive desire to use the internet plagued by highly unproductive use of the World Wide Web can be problematic. Internet addiction is characterized by an individual’s desire to use the internet for things like social interaction, playing games, gambling or shopping compulsively in a way that reduces productivity, causing problems in life and leads to adverse consequences.
For immediate help, call
888-664-1143 to talk to a counselor.
If you are using the internet to the point in which your health, relationships, finances or productivity at work or home is suffering there’s a good chance that internet addiction is to blame. Otherwise known as computer addiction, online addiction or internet addiction disorder, this compulsive need to use the internet can cause many drastic problems in an individual’s life.
How Internet Addiction Develops
Internet addiction can develop in a number of ways. Most often, it’s the compulsive use of the internet that develops as a result of a desire to gamble, shop or talk to others that is the main cause. Not all people who use the internet to do these things are addicted. Some people can surf the web for many hours a day without ever suffering from an actual dependence or addiction while others may be predisposed to having adverse reactions to their desire to surf. Every person’s internet use is different and addiction is not necessarily a problem for each user. The way to tell for sure lies in the activities that are taking place when online and the ways that such activities affect an individual’s personal life.
Signs & Symptoms of Internet Addiction
Various signs or symptoms can be evident when an individual is addicted to the internet. These symptoms will often differ from person to person and are not set in stone. There is no set amount of time that, when spent on the computer, is indicative of internet addiction. Here are some of the potential signs & symptoms of internet addiction that you should look out for:
- Spending a lot of time online and losing track of time spent online
- Having trouble completing other task such as work or home related tasks because of a desire to be online
- Isolating yourself from friends or family members in order to spend time online
- Becoming aggressive or offensive when time can’t be spent online or online time is limited
- Feeling guilty about internet use
- Finding excessive enjoyment in activities that take place online such as having sexual gratification or feeling excitement about being online
When to Seek Help
If you or someone you love is addicted to the internet or has shown signs of compulsive internet use, it’s time to seek help. There are various options available to assist you in getting over an internet addiction and making a full recovery. For instance, you may find that therapy and counseling work well or a support group could be beneficial—just make sure the support group takes place in a real environment not a cyber-world. Managing internet use is important on all levels, whether addiction is a problem or not.
If internet addiction has caused problems in your life, either in a relationship or at work or within yourself, it’s time to get professional help. Most counselors will agree that the key to treating internet addiction is to get to the bottom of the problem and find out why the internet is compulsively used. For a compulsive gambler, counseling and therapy must focus on the gambling problem in addition to the internet addiction. For a compulsive shopper, the shopping must be addressed in addition to the internet addiction.


text:
Ashanti yearns for the love and affection of her man at 2:35 am in the morning on the smooth string-laden piano jam.
235 (2:35 I Want You) follows Ashanti’s 2019 single Pretty Little Thing, featuring Afro B. Her last album Braveheart came out in 2014. It was released independently under her label imprint Written Entertainment.
Listen to Ashanti’s new single “235 (2:35 I Want You) ” below.

domain: celebrity


Filippo Radicchi在PHYSICAL REVIEW X （4, 021014，2014）上发表了关于耦合网络对信息传播的影响的研究工作，摘要如下：
Networks in the real world do not exist as isolated entities, but they are often part of more complicated structures composed of many interconnected network layers. Recent studies have shown that such mutual dependence makes real networked systems potentially exposed to atypical structural and dynamical behaviors, and thus there is an urgent necessity to better understand the mechanisms at the basis of these anomalies. Previous research has mainly focused on the emergence of atypical properties in relation to the moments of the intra- and interlayer degree distributions. In this paper, we show that an additional ingredient plays a fundamental role for the possible scenario that an interconnected network can face: the correlation between intra- and interlayer degrees. For sufficiently high amounts of correlation, an interconnected network can be tuned, by varying the moments of the intra- and interlayer degree distributions, in distinct topological and dynamical regimes. When instead the correlation between intra- and interlayer degrees is lower than a critical value, the system enters in a supercritical regime where dynamical and topological phases are no longer distinguishable.
Nature Physics在2014年6月第10卷以Improve your virality为题，对该文进行了评述，全文如下：
Messages or videos posted on the internet can attract a lot of attention by being ‘liked’, tweeted, blogged and e-mailed. But how do things go viral? Understanding information transfer in the real world is far from trivial. One has to consider not just how information disperses through a complex network, but also how it spreads between many different networks, all of which are intertwined. Take social media, for example. Facebook, Twitter and Instagram — to name just a few —could all be thought of as separate networks, but in reality they’re all intimately linked, simply by virtue of the fact that they share common users. How, then, does information diffuse through this network of networks? Conceiving the problem as a single multilayered network (in which each layer represents a different social network), Filippo Radicchi has shown that information transfer in this complex system is directed by the correlation between connections in the different layers (Phys. Rev. X 4, 021014; 2014). Radicchi looked at two interconnected network layers with randomly placed lateral (intralayer) and vertical (interlayer) connections. He explored the diffusion processes for different relationships between the number of neighbours that a node has within a network and the number of neighbours that it has in the other network. Perhaps counterintuitively, he found that a strong Improve your virality ©DJAHAN/ISTOCKPHOTO/THINKSTOCK correlation between lateral and vertical connections does not make diffusion across the whole system more efficient. Instead, information spreads faster in the opposite case: when, for example, abundant connections in one layer corresponds to sparse connections in the other. This suggests that if a strong correlation existed between, say, the Twitter and Instagram networks such that users had similar followings in both, then it would be more probable for information to travel either within one network or between the two. If, however, there was an inverse correlation — an often-followed Twitter user gaining little or no traction on Instagram — information could spread simultaneously between and within both networks. Quite apart from revealing how to become the next internet sensation, this study has implications for many other interconnected systems. It suggests a simple design principle for inducing rapid diffusion through a multilayered network: make lateral hubs distinct from vertical hubs. On the other hand, if it’s containment you’re after, it pays to build strong correlations between connections in different layers.


Former Ghanaian captain has expressed his disappointment at the omission of Majeed Ashimeru from the Black Stars squad to face Nigeria in the upcoming World Cup qualifiers play-off.
According to Asamoah Gyan, Majeed Ashimeru is the best Ghanaian midfielder after Arsenal’s Thomas Partey.
Taking to twitter, Asamoah wrote;
However, at dawn on March 3rd, 2022, the Ghana Football Association of Ghana released the much awaited squad list to face the super eagles of Nigeria.
Mohammed Kudus and goalie Richard Ofori have returned to the Black Stars after being named to the team for the important World Cup play-off against Nigeria.
After missing the 2021 Africa Cup of Nations in Cameroon earlier this year due to injury, the two crucial players are back.
Three debutants, Denis Odoi, Elisha Owusu, and Denis Odoi, are among the 27 players called by coach Otto Addo.
Both Belgian footballers...continue reading


The Indian Army will soon induct the Rudra Advanced Light Helicopter (ALH), armed with advanced air-to-air and anti-tank missiles, along the Pakistan border and western front.
The twin-engine chopper is a variant of the ALH Dhruv helicopter and is armed with an array of guns, rocket pods, and air-to-air and anti-tank guided missiles.
The aerial platform will enable army field commanders to use decisive combat power anywhere in the battlefield, according to Press Trust Of India.
The weaponised helicopter is part of modernisation and capability development efforts and is expected to boost the army’s aerial firepower capabilities.
The Indian Army will also induct and deploy 114 Light Combat Helicopters (LCH) along the mountainous terrain.


text:
Piece of Cake?
When I was offered the promotion from Unit Manager to Regional Supervisor for Campus Cooks, I thought to myself, “Piece of cake. I’ve got this.” Running an operation was nothing new for me. I’d ran restaurant kitchens, catering kitchens, and was a major principal at a retail grocery store. At one point in the past, I had even branched out from operations and taken the additional role of marketing manager just to have a new challenge. I’ve always been keen on new goals and new challenges, so Regional Supervisor sounded like a great next step.
And while it has been a great next step, I have to admit, after my first full week as a Regional Supervisor, I realized that I wasn’t so much being handed a piece of cake as being handed a recipe for cake. My next steps were to source the ingredients, measure, mix, bake and decorate several cakes from this recipe. And additionally, I realized that the recipe needed to be altered slightly for each house I was to provide cake.
Okay, enough with the cake baking metaphor for a minute. When I started as a regional, I found out very quickly that my work begins long before the chef starts to prep that first meal. In fact, it is my duty to make sure we have an appropriate kitchen, find out the needs and wants of each individual house, and to find the right chef for each house. From there, I have to make sure the chef is properly trained, that all standard operational procedures are being followed, and that we know exactly what the client expects of that chef and his staff. Then, I have to make sure that the chef knows exactly what the client expects.
Then starts the paperwork and the conversations. I’m viewing menus. I’m watching ordering. I’m talking to vendors. Additionally, I am liaison between the house management and the chef and the chef and the company principals and the company principals and the house management. Whew!
Luckily, I have the entire Campus Cooks team behind me. From John and Carl in our training department to our directors of operations, there is a dedicated staff eager to help me mix, bake, and decorate these cakes. So, yes, it is a lot more than a piece of cake, but I’ve always believed that a cake tastes better when we make it ourselves anyway.
- David Thornton, Regional Supervisor

domain: food


text:
Let’s just make sure that we all understand what is going on here: The Democrats received a historic beating in the 2014 midterms, they have a depleted political talent pool as a consequence, the plight of House Democrats is real and horrible, and President Obama’s reply to all of this is “Don’t worry, be happy.”
For anyone expecting postelection contrition at the White House or vows to change course after a disastrous election for Democrats, President Barack Obama had one message Wednesday: Think again.
A day after Democrats lost control of the Senate and suffered big losses in House and governors’ races across the country, Obama struck a defiant tone. He defended his policies, stood by his staff and showed few signs of changing an approach to dealing with congressional Republicans that has generated little more than gridlock in recent years.
Rather than accept the election results as a repudiation of his own administration, the president said voters were disenchanted with Washington as a whole. And rather than offering dour assessments of his party’s electoral thrashing, as he did after the 2010 midterms, the president insisted repeatedly that he was optimistic about the country’s future.
[. . .]
The president’s sunny outlook stood in sharp contrast to the gloomy electorate. Most voters leaving polling places said they didn’t have much trust in government and felt the nation was on the wrong track. Those feeling pessimistic were more likely to vote for Republican congressional candidates, according to exit polls.
[. . .]
“I would enjoy some Kentucky bourbon with Mitch McConnell,” said Obama, who last year mocked the idea of having a drink with the GOP leader.
Then, offering a glimpse into how little time Obama has spent cultivating a relationship with McConnell over the past six years, the president added, “I don’t know what his preferred drink is.”
Those last two paragraphs really sum things up, don’t they? This president is not nearly the great politician his admirers make him out to be, he is bored with politics and with governing, and he has absolutely no idea how to follow Abraham Lincoln’s formula for destroying enemies by making those enemies into friends.
Ron Fournier has it right:
And then he ignored them.
From all appearances Wednesday, the president won’t change—not his policies, not his style, not his staff, not nothing. Defiant and begrudging, the president said he would meet with GOP leaders, seek their suggestions for common ground, and maybe grab a drink with Senate Majority Leader-to-Be Mitch McConnell.
Beyond that, meh. “It’s probably premature” to consider personnel changes, Obama said when pressed by a reporter for the type of reflection and resetting undertaken by President Clinton after his 1994 midterm trouncing.
You know who is really upset by this kind of stance? People like Hillary Clinton, who must fear that another two years of the same old thing from the Obama administration will bring about another shellacking–this time, in 2016 and this time, affecting the next Democratic nominee for president of the United States. Maybe Republicans should let President Obama dig a rhetorical hole for himself and his party by pretending that the midterm elections were not nearly as bad for Democrats as everyone realizes them to be. The president seems determined to live in the Land of Denial, after all.


text:
Sep 15, 2017
Ricky Melton is a local Cleveland comedian who is putting on a big comedy show on October 14th. He's bringing Artie Lange to town to play the Goodyear Theater in Akron. The show will feature Lange, Mike Polk Jr., Bill Squire, Chris Harvey, and of course Ricky himself.
You should check out the Facebook event or
On the podcast, Ricky recounts the time Saved by the Bell's Screech tried to renegotiate his deal and selling an embarrassing video of him to TMZ.

domain: entertainment


text:
The Swedish company’s new medium format range marks their return “to the top of the photography pyramid”, Hasselblad’s CEO says
Hasselblad has announced the H6D, a new range of cutting-edge medium format cameras.
With two models boasting up to 100-megapixel resolution and a wider range of shutter speeds from 60 minutes to 1/2000th of a second, the new range brings serious credentials to the professional market.
Launched by Hasselblad CEO Perry Oosting earlier this morning, the company note that the camera marks a break from their existing medium format H cameras, with the new H6D range taking advantage of the latest technical components and an all new electronic platform. “We’re back on top of the photography pyramid,” Oosting said at the press conference, held in London.
While Hasselblad has experimented with different models and formats in recent years, such as the APS-C Lunar and the full-frame Lusso, Oosting noted that the H6D marks a commitment to the format for which Hasselblad is best known: “It’s fitting that we have returned to our pinnacle medium format camera to showcase the innovation and passion that have been present in every one of our first 75 years.”
The first cameras from the all new range are the H6D-50c and the H6D-100c, CMOS sensor-equipped cameras with 50 and 100 megapixels, respectively.
Aiming to capture the high end of the professional market, the H6D-100c includes a dynamic range of 15 stops, an ISO range of 64-12,800 and a metering range of EV 1 to 19 at ISO 100.
The 100c also packs 4k video capabilities, and with Wi-Fi, dual card slots (CFast and SD) and HDMI connectivity, the camera could intrigue photographers looking to utilise the qualities of medium format to shoot video.
The Hasselblad H6D-50c is priced at €22,900 (ex VAT). The H6D-100c is priced at €28,900 (ex VAT), with trade-in options for existing Hasselblad owners.
More to come…


text:
Thank you all for the interesting questions. Today I will answer 5 of them; I promise to keep them short.
1. What's something that makes you genuinely happy whenever you think about it? Writing makes me happy anytime think about scenes, characters; you name it.I am also happy when I cook, clean, and help others.
2. What inspires you to write Flash Fiction? Songs, key moments, what-if situations, and daydreams. I do it for the practice, ultimately I want to write novels, and Flash allows me to expand the creative horizons. I crave the escape.
3. Why is your Avatar a penguin? I love penguins, I think they Nobel birds. March of the Penguins had me crying, and happy Feet is my all-time favorite movie
4. Where do you see your writing taking you? Good question, I don't know, but it's ok not to know. My intuition tells me it is the direction I must go regardless of my day job. Have no fear, trust yourself! I am working on making it full-time.
5. What is your favorite color? At this time, it is purple. It changes with the seasons and moods.
Thank you for tuning in to everyone. :D Let me know in the comments: What you recommend we do next to celebrate reaching the 250 milestones. Challenge Poetry, maybe flash a collab, lets get creative. :D

domain: literature


Barnard Griffin Wine Bar & Eatery will feature the music of the Frazer Wambeke Trio on July 5 and Faith Martin on July 6.
There is no cover charge, and the music starts at 7 p.m. The winery is at 878 Tulip Lane in Richland.
Digital Access for only $0.99
For the most comprehensive local coverage, subscribe today.


The Boston School Committee is considering adopting a new policy that would add sexuality education and other health courses and make condoms available at all high schools in the city. The move to change these policies comes as the city is seeing high rates of sexually transmitted infections (STIs), especially chlamydia, among teens. In 2012, there were 1,249 cases reported among 15- to 19-year-olds in Boston.
Currently the city’s schools are operating under a policy that was controversial when it was passed in 1994. It allows for condom availability only at the 19 schools that house school-based health centers (there are a total of 32 high schools in the city). At the time, Mayor Thomas M. Menino pushed for the policy out of a concern over rising HIV-infection rates among teenagers in the city. The policy passed despite staunch opposition from the previous mayor and the Catholic Archdiocese of Boston.
It has not been updated in nearly a decade, however, and many people in the city, including students, think it does not go far enough. According to the Boston Globe:
In the Fall of 2010 young people from the Hyde Square Task Force in Jamaica Plain launched an aggressive campaign to persuade school officials to offer free condoms in all high schools, and to increase the rigor and availability of sexual health education courses, which they said had been dropped from several schools because of budget cuts or MCAS [standardized test] prep.
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In fact, only eight of the 32 high schools in the city currently offer sex education.
The school committee is now considering a number of these proposals. Under the suggested condom policy, students at all city schools would be able to receive condoms either from school staff, the Boston Public Health Commission, or a community health service partner. Any student receiving condoms would be given counseling on safer practices at the same time. Parents who do not want their children to receive condoms could opt out of the program.
This policy would be part of a larger health and wellness program, which would apply to all grade levels and include improved physical education classes, education about nutrition, bullying prevention programs, and sexuality education.
Members of the school committee seemed supportive of these changes, including condom availability, when they met at the beginning of the month. The committee’s chairman, Michael O’Neill, told the Globe, “Many members spoke positively about the comprehensiveness of the policy and acknowledged the reality our students face.” No one spoke out to oppose changing the policy.
The school committee is set to meet again on June 19.


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The building where the shooting occurred also houses multiple businesses, including an escape room, a beauty salon and a spa. Police did not say if the woman lived in the apartments, was a customer or was just passing by. It was not clear if the shooting took place indoors or outside.
No other details have been released.
In 2021, the apartment complex was at the center of a lawsuit following the death of JauMarcus McFarland, an 18-year-old football player who was killed when an elevator collapsed in the building where he and many team members lived, The Atlanta Journal-Constitution previously reported.
McFarland, who was from Missouri and played football at Champion Prep Academy, was among a group of players who boarded the elevator in September of that year. The elevator doors opened on the third floor while it was in a “slow decline mode,” according to an accident report. Three players were able to jump off, and McFarland followed, but became pinned as the elevator descended halfway below the third-floor level.
Following the incident, the complex received a $5,000 citation, the maximum fine possible for failing to notify the state’s Office of the Commissioner of Insurance and Fire Safety of an accident that resulted in death.


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Bristol City are preparing for Saturday’s away trip to Reading in the Sky Bet Championship.
West Brom loanee Jonathan Leko – who has been on international duty – could also play some part if in the squad for the visit up the M4.
City will hold their pre-match press conference later this week ahead of the game – where the Post will be providing updates on the latest team news, injuries and City updates.
Follow all the latest news, views and transfer gossip throughout the day with our live blog.
Australia and Bailey Wright
The Bristol City defender was involved as the Socceroos took another step towards qualification for the 2018 World Cup with victory over Thailand.
The hosts made hard work of it in Melbourne, and it was Matthew Leckie’s 86th-minute goal that grabbed them three points.
Australia must now hope that Saudi Arabia fail to beat Japan later today in hope of qualifying automatically.
Big not for Callum O'Dowda
The Bristol City winger is on international duty and the Republic of Ireland play Serbia this evening at Aviva Stadium.
Finally. After hitting the post on numerous occasions, Bailey Wright’s Australia side are ahead against Thailand in a crucial World Cup qualifier.
Connor Lemonheigh-Evans injury update
The Bristol City midfielder, who is out on loan at Bath City, was recently stretchered off playing for the Romans against Poole Town.
But talking to the Bath Chronicle, Gary Owers says its not as bad as first thought.
“I don’t think Connor’s injury is as bad as everyone thought, so there’ll still be a period where he’s unable to play, maybe four or five weeks, and we’ll have to assess that when he’s available again.”
Aden Flint Instagram post
City fans were happy to see this posted by the big defender.
Will Bristol City defender get a start for Australia?
The Socceroos play a must-win game against Thailand today in Melbourne - and we could see out very own Bailey Wright in action.
Team announcement coming very soon.
Second England showing for Lloyd Kelly
The Bristol City left-back was in action last night for England 20s...
Former Bristol City coach comments about George Dowling
John Pemberton, who left the Robins last season, took to social media recently with praise for young midfielder George Dowling.
He scored a stunning goal and grabbed a man-of-match for loan side Torquay last weekend.
It’s raining and depressing when it comes to the weather, but Bristol City are back in action this weekend as the international break comes to an end.
City will hold their pre-match presser later this week, so what’s the latest as things stand.
Let’s get going this morning...


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The sub-committee, constituted by the Drugs Controller General of India (DCGI), has submitted the guidelines on post-approval changes in drugs to the Union Health Ministry which are today very important from the standpoint of global regulatory harmonisation.
This, according to a senior official, will do away with unauthorized and upright changes in the product. These guidelines which are adopted in the regulated markets will streamline the protocols to make post approval changes in the drug as it is closely related with the product life cycle approach.
DCGI had constituted a sub-committee to frame guidelines on post approval changes to pharmaceutical products in line with the global regulatory framework in November 2019.
The sub-committee was constituted under the chairmanship of Telangana drug controller Dr Venkateswarlu with Dr H G Koshia, Gujarat Food and Drug Control Administration (FDCA) Commissioner, D K Tiwari, assistant commissioner (Drug), Uttar Pradesh Food Safety and Drug Administration Department (FSDA UP) and Arvind Kukrety, Deputy Drug Controller (DDC) as members to draft guidelines on post-approval changes to pharmaceutical products.
The guidelines will cover changes like facility, scale and equipment changes associated with all steps of drug substance manufacturing, specification changes to starting materials, raw materials, intermediates and the unfinished and final drug substance.
These guidelines which are also being followed in all the developed markets marks a major step by the Indian drug regulator to align with the global regulatory framework as per global regulatory harmonisation.
Though Drugs and Cosmetic (D&C) Rules have been amended to raise compliance levels since 1940 but these guidelines were not mandated. Since India is the pharmacy hub to the world, these guidelines need to be adopted and implemented to ensure compliance and quality at par with global counterparts.
This also includes synthetic manufacturing process changes, changes in the source of drug substance and changes to the container closure system of the drug substance.
The matter was deliberated during the Drug Consultative Committee (DCC) meeting held in Delhi in September 2019 to bring in similar guidelines for Indian pharmaceutical industry as per global regulations.
This will help over 6,500 Schedule M units in the country to improve product quality, according to regulatory experts.
There are around 8,000 Schedule M units in the country and around 1,300 WHO GMP compliant units follow these guidelines.
As per the USFDA guidelines, manufacturers of active pharmaceutical ingredients (APIs) who want to make changes to the drug substance (DS) manufacturing process during an application’s post-approval period should consult USFDA (Food and Drug Administration) new draft guidance released on September 10, 2018.
The guidelines provide recommendations to holders of approved new drug applications (NDAs), generics (abbreviated new drug applications, (ANDAs), new animal drug applications (NADAs), abbreviated new animal drug applications (ANADAs) and holders of drug master files (DMFs) and veterinary master files (VMFs) who may want to make a change to the drug substance manufacturing process during the drug product application´s post-approval period.
The guidelines note that late-stage changes in the drug substance manufacturing process are generally viewed as “more likely to have an adverse impact on the quality of the drug substance and, consequently, on the drug product.”
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How to Fix Leak Between Toilet Tank and Bowl
Is your toilet leaking between the tank and the bowl? If you see water leaking down the base of your toilet, or pooling on the floor, it could be a sign that your tank to bowl gasket is leaking. Water belongs in your toilet not on the floor, let's get that fixed.
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In Indonesia, one man and his horse have created a walking, braying mobile library to bring books to the remote villages on Java island.
Ridwan Sururi, 42, travels between schools and villages with a tamed wild-horse called Luna who is loaded with boxes of donated books. Sururi named his project Kudapustaka, meaning ‘horse library’ in Indonesian, according to the BBC.
Illiteracy remains high in the rural heartlands of Central Java, despite huge strides to improve literacy rates across the country. “I love horses, and I want this hobby to bring benefit to people,” Sururi told the BBC. READ MORE: How One Man And His Horse Created A Mobile Library In Indonesia | Huffington Post


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"This information and website content is not intended to diagnose, guarantee results, or recommend specific treatment or activity. It is designed to educate and inform only. Please consult your physician for a thorough examination leading to a diagnosis and well-planned treatment strategy. See more details on the DISCLAIMER
page. Content is reviewed by Dr. James M. Cox I

domain: health


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James Ennis' contract will become fully guaranteed on opening night of the 2015-16 season and not 50 percent guaranteed on Aug. 1.
Kobe Bryant could play some power forward against smaller teams.
Doug McDermott is expecting more minutes this season and said coach Fred Hoiberg wants him to move more without the ball.
The Hornets will sign Eliot Williams for training camp.
Ognjen Kuzmic will sign with Panathinaikos BC.
The Heat will pick up Tyler Johnson's contract, according to Ira Winderman of the South Florida Sun Sentinel.
Jae Crowder (knee) said his knee feels 100 percent.
President Larry Bird said Lavoy Allen will play more at power forward and center next season.
Warriors sign G Ian Clark.
Heat waive G/F Henry Walker.
Blazers acquired C Brendan Haywood and G/F Mike Miller from the Cavaliers.
Tarik Black, who had been previously listed at 6'11", is now listed at 6'9".
Magic acquire G Shabazz Napier.
Roy Hibbert is excited to play for Byron Scott.
Chris Babb was traded to the Warriors in the David Lee-Gerald Wallace deal on Monday.


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domain: design


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Michigan State students march for sexual assault survivors
- Author: Jill Young Jan 27, 2018,
Jan 27, 2018, 19:15
Searing victim testimony during former American gymnastics team doctor Larry Nassar's sentencing hearing has ratched up pressure on the sport's US governing body and Michigan State University to settle civil lawsuits by girls and women seeking to hold them responsible for his years of sexual abuse, legal experts said.
Many victims said they reported Nassar's abuse to various members of Michigan State's staff. Campus police got their first report regarding Nassar in 2014, but the Ingham County prosecutor declined to file charges.
Hollis said that he was not asked to retire or pressured "in any way" to leave his post.
I have received many questions and inquiries about today's reports.
A MI judge on Wednesday sentenced Nassar to 40 to 175 years in prison for sexually abusing young female athletes in his care. Several of the victims who addressed the court were former athletes at the university, and many victims charged the school with mishandling complaints about Nassar as far back as the late 1990s.
Nassar, 54, served as the USA gymnastics team physician for several Olympic Games through 2012 and worked at Michigan State since the 1990s.
Skywatchers getting a lunar trifecta - supermoon, blue moon and eclipse
Before dawn this Wednesday, Jan. 31, the first total lunar eclipse of its kind in over 150 years will take place. Adding to the naming confusion, this full moon was also known as the "snow moon" by some Indigenous tribes.
Those key findings were never shared with Amanda Thomashow, the patient who said Nassar had assaulted her.
The resignation comes two days after MSU President Lou Anna K. Simon submitted her resignation and a day after an ESPN Outside the Lines report found the Michigan State University failed to hand over documents that outlined accusations of sexual assault by former trainer Larry Nassar to Title IX investigators. The school's governing board expressed support for Simon, but she eventually succumbed to pressure from students, faculty and lawmakers.
Many people from within the university told Hollis he should "not do this", but insisted it was the appropriate response for the survivors of Nassar's abuse.
The MSU Board of Trustees voted unanimously Friday afternoon to accept Simon's resignation and appointed trustee Bill Beekman as acting president until an interim one is named. Board member Joel Ferguson apologized this week for saying previously that some victims were ambulance chasers seeking a payday.
The protest, titled "March for Survivors and Change at MSU", will be held on Friday.
Hollis, who had been in the job for 10 years, disclosed the move during a meeting with a small group of reporters on campus.
South African markets strengthen on prospects of a Zuma exit
It could also boost the party's electoral chances next year because it would no longer be so closely associated with Zuma's legacy.
Yes. Michigan State is under the microscope. Yes. Some gymnasts said assaulted them there.
"The Penn State crisis - and this has a good deal of similarities - was the biggest sports story in 2012", said Gerald Gurney, an assistant professor of Adult and Higher Education at the University of Oklahoma.
"Larry Nassar's heinous crimes of record against more than 150 victims raise serious concerns about institutional practices, student-athlete safety and the institution's actions to protect individuals from his behavior", the letter reads. They seek more changes.
Ex-MSU Gymnastics Coach Kathie Klages retired in February 2017, amid the Nassar scandal.
Padmaavat protests: Supreme Court to hear plea by Rajasthan, Madhya Pradesh today
The petition has requested the court to review its order that lifted the ban on the government-imposed ban on the movie. As the release date is approaching, there are a lot of protests happening in multiple states especially Rajasthan.


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BBVA Compass 3Q earnings show large increase
BBVA Compass reported a 91 percent increase in net income for the third quarter, the Birmingham-based bank announced today.
BBVA Compass posted $123 million for the quarter ended Sept. 30, compared to $65 million the previous year.
Its provision for loan losses dipped to $2 million in the third quarter from $97 million in 2011’s third quarter.
Total loans increased 8 percent to $45 billion and total deposits climbed 11 percent to $50.2 billion from the prior year’s figures, the bank said.
Its key credit quality metrics show improvement with nonperforming loan ratio dropping to 2.7 percent from 4.5 percent; net charge-off ratio declining to 0.49 percent compared to 1.40 percent and nonperforming loan coverage ratio increasing to 73.4 percent from 58.3 percent.
Manolo Sánchez, BBVA U.S. country manager and president and CEO of BBVA Compass, said in a statement that while the economic and interest rate environments continue to present challenges across the industry, BBVA Compass’ customer-centric business model has allowed the bank to continue to deliver outstanding profitable growth.
Antrenise Cole covers banking, finance, small business lending, venture capital, accounting and law for the Birmingham Business Journal. Click here to follow her on Twitter.
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domain: economics