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[show abstract][hide abstract] ABSTRACT: At the 2005 Annual Meeting of the American Academy of Child and Adolescent Psychiatry (AACAP), the Academy's Workgroup on Research conducted a Research Forum entitled "Increasing Research Literacy Through the Adoption of Evidence-Based Practice (EBP) in Pediatric Psychiatry."
Forum participants focused on speeding the adoption of EBP across five areas: EBP as the preferred heuristic for teaching research literacy, use of EBP in training programs, dissemination of EBP in clinical practice, EBP in partnership with industry, and EBP as a framework for developing practice guidelines.
EBP provides an easy-to-understand method for accessing and evaluating the research literature and then applying this information to decisions about patient care. Although EBP has been gaining greater visibility in pediatric psychiatry, it is far from the preferred heuristic. To move the field toward fully embracing EBP will require greater understanding of what EBP is (and is not), educating mental health professionals in EBP skills, access to EBP resources, and a commitment to apply EBP to the conceptualization and design of research protocols and practice guidelines.
Pediatric psychiatry would benefit from a principled commitment to follow other areas of medicine in adopting EBP.
Journal of the American Academy of Child & Adolescent Psychiatry 10/2007; 46(9):1098-110. · 6.97 Impact Factor
[show abstract][hide abstract] ABSTRACT: The aim of this study was to examine the balance between the benefits of treatment and the risk of suicidality in children and adolescents in multicenter, randomized, controlled trials of sertraline versus placebo.
The published literature was searched for multicenter, randomized, placebo-controlled trials of sertraline for pediatric mental disorders. Four trials were identified: Two (pooled) in pediatric major depressive disorder (MDD; Wagner 2003) and two in obsessive-compulsive disorder (OCD; March et al. 1998; POTS Team 2004). Using intent-to-treat (ITT) analysis populations, the authors calculated the number needed to treat (NNT) for response and remission and the number needed to harm (NNH) for suicidality, and their ratio, for each clinical trial.
NNTs ranged from 2 to 10, indicating clinically meaningful benefits. Benefit was greater for OCD than for MDD, and for adolescents as compared with children in MDD. No age effect was apparent for OCD. Suicidality was reported in 8 patients (5 assigned to sertraline and 3 assigned to placebo). All but 1 (a placebo-treated patient in the Pfizer OCD trial) were enrolled in the sertraline MDD trial. The NNH for suicidality in MDD was 64. Treatment emergent suicidality was more common in children (NNH 28.7) than in adolescents (NNH 706.3). Because no patient developed suicidality in sertraline-treated OCD patients, the NNH for sertraline in OCD approaches infinity.
With the stipulation that doctor and patient preferences necessarily play a critical role in the choice of treatment, NNT to NNH ratios indicate a positive benefit-to-risk ratio for sertraline in adolescents with MDD and in patients of all ages with OCD.
Journal of Child and Adolescent Psychopharmacology 01/2006; 16(1-2):91-102. · 2.77 Impact Factor


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A Gynecologist's View
Gynecologist Judi Chervenak, an associate clinical professor of obstetrics-gynecology and women's health at Montefiore Medical Center and Albert Einstein College of Medicine in New York City, said she will tell her patients this: "From age 39 on, a woman should have a yearly visit to her health-care provider, during which she discusses which routine tests are appropriate for her, including mammography."
But, she also said she favors mammography for many women.
"Unless the patient is at increased risk of radiation exposure or increased mental health stress of dealing with a false-positive test, I still feel that the use of the mammogram is a potentially lifesaving and quality-of-life improving test for many women," Chervenak said.
"We know that mammography often picks up a cancer before it can be palpated," she said. "We have to do everything we can to maintain our quality of life."
A Family Physician's View
A woman should remember that the guidelines are based on the entire population and that her own decision must be an individual one, said Dr. David Baron, a family physician and chief of staff at Santa Monica-UCLA Medical Center and Orthopaedic Hospital in Santa Monica, Calif., and an assistant clinical professor of family medicine at the David Geffen School of Medicine at the University of California, Los Angeles.
"That's why communication between a patient and her health-care professional is very important," Baron said.
The new guidelines, in his view, are encouraging physicians to individualize the screenings.
"Some of this will depend on how risk-adverse a woman is," Baron said. A 40-year-old woman, for instance, might be afr
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Akshay Kumar recreates ‘Main Khiladi Tu Anari’ magic on Saif Ali Khan’s birthday
Akshay Kumar recreated the magic of 1994’s ‘Main Khiladi Tu Anari’ on co-star Saif Ali Khan’s birthday
Akshay Kumar receated the magic of 1994’s ‘Main Khiladi Tu Anari’ on co-star saif ali khan’s birthday
Renowned actor Akshay Kumar wished Saif Ali Khan on his birthday by dancing to the song Main Khiladi Tu Anari, and also wrote down a heartfelt note for him.
The Raksha Bandhan actor shared a video on his Instagram account dancing to the classic song from the 1994 film, with the caption: “It’s been 28 years but dancing again to the tunes of Main Khiladi Tu Anari for #Selfiee still brings back fondest memories.”
He added: “Especially when it happens to be the birthday of my partner-in-crime in the original, Saif Ali Khan. He’s not on social media but wishes reach nonetheless. Happy Birthday, brother!”
Both Akshay and Saif starred in the original movie together which, at the time, became the fifth highest grossing movie of the year.
The duo also starred in many other movies after its success, including Keemat-They Are Back, Dillagi, Tu Chor main Sipahi and Tashan, as per Times of India.
On the work front, Akshay is currently working on Selfiee along with Nushrat Bharucha and Emraan Hashmi. He also has OMG 2, Bade Miyan Chote Miyan and Ram Setu in the pipeline.