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In support of their new album 13, available on cd and vinyl, Black Sabbath descended on Houston Texas and made me a happy metal head!
Original members Ozzy Osbourne, Geezer Butler and Tony Iommi and replacing drummer Bill Ward, touring drummer Tommy Clufetos.
I was a little sad Bill Ward did not rejoin the band but his replacement was truly amazing and even gave a fantastic 70's style drum solo.
Just before the show I found a copy of 13 on vinyl and would have bought it but the back album sleeve was damaged and they only had the one copy. I had not heard the new album yet except for youtube clips and I was excited to hear live versions of new songs for the first time.
The stage was dark and then a light came on back lighting Ozzy's iconic silhouette behind the massive stage curtain, air raid sirens began to wail amidst flashing red lights, the curtain lifted and they began the opening song WARPIGS!!!
And I went nuts!
Except for maybe 4 new songs my favorite being God Is Dead, Sabbath delivered the hits one after another.
Not in this order they played, War Pigs, Black Sabbath, Snow Blind, N.I.B., Fairies Wear Boots, Into The Void, Beyond The Wall Of Sleep, Iron Man, Rat Salad, Dirty Women, Children Of The Grave, and for an encore they played the opening riffs of my favorite Sabbath song Sabbath Bloody Sabbath, and I screamed louder than I ever have in my entire life but it was a fake out as they then broke into Paranoid which was still amazing!
I bought one concert T and a shot glass and called it good.
It was a fantastic experience hearing the Heavy Metal legends themselves playing their historic songs. And an honor to pay them homage and support them on tour.
Ozzy was my introduction into Heavy Metal back in the 80's and I had not seen him live so to see him with Sabbath was a double wish fulfilled! I never thought I would ever see Black Sabbath perform, and it was one of if not the best concert experiences I have ever had.
I Sold My Soul For Rock 'N' Roll!
And I would do it again!
So glad you could live your heavy metal dream! How far did you have to travel to attend the show?
I live about 40 miles north of the venue. But I really didnt mind the distance.
It was worth it as I had always wanted to see Ozzy and Sabbath.
I can remember a conversation I had with a girlfriend almost 20 years ago about how awesome it would be to see a reunited Sabbath and how everyone and their dog would want to go. Real gooney teen conversation, and I up and went!
So it really was a dream come true.
I cant wait to pick up the new record, and I'll post it as soon as I do!
I'm celebrating musically as well - I've been contacted by the man who remastered and released the 6 new unofficial KLF mixes/recordings. He said he loved my blog and is sending me pre-release copies of the next two discs in the series!
And, Friday, Aug 2nd I will be locking in a $225 vinyl purchase on my holiest of holy grails. I promise to post it to the group when it arrives!
A great summer for audiophiles all around.
Wow, thats cool!


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JAV Sub Indonesia Yui Hatano ADN-032 - Watch online streaming JAV Sub Indonesia Yui Hatano ADN-032 - Or download JAV Sub Indonesia Yui Hatano ADN-032 free.
Feel free to watch online or download JAV sub indo in this site. You will love this Japanese video since it has subtitle in Indonesia language for you to understand the dialog in the movie.
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This JAV indo-subtitle released with JAV ID: ADN-032, produced by Attackers AV Studio, and starring by beautifull and popular JAV actress Yui Hatano (波多野結衣).JAV Sub Indonesia Yui Hatano ADN-032 Synopsis:
The story is about the former student who eventually wins over his ex-sensei (ex-teacher). He fall in love with her, and decided to rape her while her husband away. Enjoy this exciting JAV story with bahasa indonesia subtitle.
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JAV Sub Indonesia Yui Hatano ADN-032 Detail Information:
- Title: JAV Sub Indonesia Yui Hatano ADN-032
- Alternative Title: Female Teacher. She Gets Wet When Meeting Her Student... Yui Hatano
- Another Title: "ADN-032" Yui Hatano Female Teacher She Gets Wet When Reunion With Her Student.. Infidelity
- Popular Title: 'ADN-032' The reunion with the female teacher 's student is wet with unfaithfulness
- Japanese Title: ADN-032 女教師 教え子との再会は不貞に濡れて…。
- Release Date: Aug. 07, 2014 (2014年8月7日)
- Runtime: 107 min. (107分)
- Director: Juzo Sonoda (園田十三)
- Channel:Playgirl, PRIME
- Content ID: adn00032
- DVD ID: ADN-032
- Series: Reunion gets wet with unfaithfulness .... 再会は不貞に濡れて…。
- Subtitles: Bahasa Indo
- JAV Actress(es): Yui Hatano (波多野結衣)
- JAV Studio: Attackers
- Label: Subtitle Indo JAV | Otona no Drama (大人のドラマ)
- Genre/Categories: Teacher | Rape |
- Good for: JAV Film With Indo Subtitle Fans
- Type: JAV Censored
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domain: entertainment


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Place: The restaurant is spacious, amply stylish, and well lighted. It's just a noisy inside, what with the hustle and bustle of food service and chatter of customers.
Food: The food is tasty, but we are hesitant to call it "the world's best" or impressive.
First on our table is the Noodles with House Special Spicy Sauce (Php 120): soft noodles with an chili-oil based sauce with some minced vegetables. This one is delicious! The noodles are firm enough to be enjoyed, and the sauce is flavorful and has the right amount of heat to whet the appetite. The subtle sweetness of the noodles complements the chili flavor very well.
Next, the Crispy Vegetarian Mushroom Wontons (Php 185, 6 pieces): fried dumplings filled with chopped greens (cabbage and kuchay?) and minced mushrooms. They come with an oil-based dip. The filling tastes O-K, not bad. One can really sense the distinct flavors of the components. The fried wrapper though is a letdown; it tastes a little stale. We think the wontons weren't fried with fresh cooking oil.
Then, the Truffle and Pork Xiao Long Bao (Php 135 per piece): dimsum filled with minced pork and minced truffles. It's not bad. The truffle flavor just needs to go up one more notch to match its price tag. Just one more notch! Bitin! We like the texture of the bun itself and what it does to the consistency of the soup inside.
Next, the restaurant's pièce de résistance, the Pork Xiao Long Bao (Php 160, 5 pieces). Again, we like the texture of the bun. As for the filling, it needs just a little more seasoning or meat flavor, just a little; it tends to be a tad too bland.
Our last savory meal are the Shrimp and Pork Pot Stickers (Php 220, 6 pieces). The filling is fresh, but it needs just a little more touch of flavor. We like nibbling at the crispy parts though.
For our drink, we have a glass of their Classic Iced Tea (Php 45). It has hints of citrus flavor. And it's not too sweet.
For dessert, we have the Chocolate Lava Xiao Long Bao (Php 115, 3 pieces). Now this one, we really like. The chocolate is glossy and velvety. It is not too sweet nor too milky. Yummy!
Price: Considering food quality, serving size, and taste, we find the fare reasonably priced.
Service: Needs improvement! We waited for more than 15 minutes for most of our dishes. Our iced tea was brought during the middle of our lunch. They served us the wrong dessert item. Yikes!
Din Tai Fung is on the Upper Ground level of Mega Fashion Hall.

domain: food


text:
Traits associated with the name Noah:
Dogs named Noah tend to be loving, good-natured, and hard-working. This name is also associated with companionship, and intelligence.
What does it say about you to have a dog named Noah?
That you have a strong appreciation for biblical stories and characters, and that you likely have a strong sense of faith.
Is Noah a good dog name?
Noah is a one-syllable dog name, making it short and snappy. Noah isn't one of the most common names, so your dog will certainly stand out. If you love the name, you should pick it!
Noah is found in these categories:
- Noah ranks #203 with users of PupNames.com.
- Noah ranks #403 in the New York City Dog Name Database.
- Noah ranks #656 in the Los Angeles Times 'Top Dogs'.
Naming your dog Noah is certainly a thing, but it's one of the more niche choices out there according to our data.
Most popular breeds named Noah:
- Labrador Retriever
- Golden Retriever
- German Shepherd
- Cocker Spaniel
Get special treats for Noah!Want cute doggy products for dogs named Noah?
Join our email list and we'll keep you updated!
Dog names like Noah:
Murderer and robber.
Man From The North
Dweller By The Ash Tee
Champion Or Passionate
Short for Nicholas/Nicole.
Acquired, or possessed; the first born son of Adam & Eve.
November 18, 2022
August 29, 2022
March 12, 2022
Let us know what you think of Noah as a dog name!

domain: pet


text:
While we all enjoy freedom of speech here in America, those in positions of public trust should be mindful of their conduct on social media.
Such is the case with an Anderson Community Schools employee who posted an offensive comment on a social media thread. The offense was made worse by the fact that comment appeared to be directed at a father grieving the recent death of his son – who was a student of ACS.
As social media becomes an ever increasing part of our lives, it is important to have rules of conduct just as we have in our daily lives.
Some of us would like to keep a thick wall of separation between our professional lives and our private lives, but the size and scope of social media no longer permits it to be considered part of our private lives.
Whether we like it, social media is public and reflects publicly on ourselves, our families and our employers. This is especially true of school personnel who are entrusted with the safety and well-being of children.
ACS should have clear social media guidelines for its employees, and violations should result in reprimand. Anyone can make a mistake, and not every infraction should result in an immediate loss of an entire career, but we expect ACS to make it clear that such conduct is unacceptable for those in its employ.

domain: news


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The young wizard made magic once again this weekend.
Book retailers Barnes & Noble Inc. and Borders Group Inc. each reported selling more than a million copies of “Harry Potter and the Half-Blood Prince” — the sixth installment in the series by J.K. Rowling about the boy wizard and his friends — Saturday and Sunday.
“This weekend was nothing short of a triumph for publishing, bookselling and reading,” said Steve Riggio, chief executive officer of Barnes & Noble, the world’s largest bookseller.
The book was officially released one minute after midnight Saturday at more than 5,000 “Midnight Magic” parties with games, treats and prizes in bookstores across the country.
Lines as long as 1,200 customers snaked throughout Barnes & Noble stores in some cities.
More than half a million fans attended special “Midnight Magic” parties at Borders Group bookstores around the globe, said Beth Bingham, Borders Group’s public relations director.
The new book broke all publishing records Saturday — selling an unprecedented 6.9 million copies in its first 24 hours on the shelves, according to Scholastic Corp., the world’s largest publisher and distributor of children’s books.
In the first 24 hours of the book’s release, bookstores sold:
287,500 copies every hour.
More than 4,791 copies every minute.
About 80 copies every second.
Despite the first day’s success, Scholastic would not disclose how many copies were sold over the entire weekend.
First-day sales at Barnes & Noble increased 40 percent over first-day sales of Miss Rowling’s previous book, “Harry Potter and the Order of the Phoenix,” Mr. Riggio said.
Barnes & Noble sold a record 1.3 million copies in the first 48 hours of its release — 378,000 of which were sold in the first hour.
On Saturday, sales topped 850,000 at Borders, Books Etc. and Waldenbooks stores worldwide — the highest first-day sales of any title in Borders Group’s history.
More than a million copies were sold over the entire weekend, Ms. Bingham said.
The previous books in the series sold well the first week, and sales remained strong during the holiday season, she said.
“The only thing you can compare it to honestly is other Harry Potter books because the last Harry Potter set topped sales records,” Ms. Bingham said. “It’s really like nothing else in publishing.”
Harry Potter is no stranger to the best-seller list: all five of the previous Potter books were top best-sellers in the United States, Britain and around the world.
Counting book six, the total number of Harry Potter books in print — published by Scholastic in the U.S. — is more than 116 million copies, according to Scholastic.
Most bookstores aren’t anticipating a decrease in Harry Potter’s popularity in between books six and seven — the last book of the series whose release date has not been announced.
“The greatest thing with Harry Potter is that the fans are sticking with it, and they’re growing up with it,” Ms. Bingham said.


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One of the most common comorbid pathology is asthma and arterial hypertension. For experimental modeling of comorbidity we have used spontaneously hypertensive rats with ovalbumin (OVA)-induced asthma. Rats were randomly divided into three groups: control group, OVA-induced asthma group; OVA-induced asthma + IL10 shRNA interference group. Target gene (IL10) was predicted by ANDSystem. We have demonstrated that RNA-interference of IL10 affected cardiovascular (tested using Millar microcatheter system) as well as respiratory functions (tested using force-oscillation technique, Flexivent) in rats. We have shown that during RNA-interference of IL10 gene in vivo there were changes in both cardiac and lung function parameters. These changes in the cardiovascular parameters can be described as positive. But the more intensive heart workload can lead to exhaust and decompensation of the heart functions. Knockdown of IL10 gene in asthma modeling induces some positive changes in respiratory functions of asthmatic animals such as decreased elastance and increased compliance of the lungs, as well as less pronounced pathomorphological changes in the lung tissue. Thus, we provide the data about experimentally confirmed functionality changes of the target which was in silico predicted to be associated with both asthma and hypertension – in our new experimental model of comorbid pathology.
Since the works of Feinstein , Kraemer and van den Akker ,  comorbidity or multi-morbidity is still in focus of many investigators worldwide . One of the most often combinations of chronic diseases is asthma and arterial hypertension  or other cardiovascular pathology , . It is not surprising because modern understanding of inflammation is beyond the classical concept of this pathological process as a response to infection and injuries, and the significance of low-grade chronic inflammation has now been established in the pathogenesis of non-inflammatory diseases (e.g. atherosclerosis, metabolic syndrome, arterial hypertension, obesity) has now been established , , , , , .
The main problem of comorbidity in clinics is poor prognosis. Polypharmacy is the next significant point: patients with two or more pathologies should receive simultaneously a lot of drugs leading to combination of side effects. Thus, it is important to find molecular targets that can be used for prospective treatment of both diseases with a single drug. Bioinformatical approaches in this situation are optimal considering huge volume of heterogeneous data for analysis. In our previous article, we used ANDSystem for the reconstruction and analysis of gene networks associated with both asthma and hypertension . The gene network for asthma included 755 genes/proteins and 62603 interactions, while the gene network for hypertension – 713 genes/proteins and 45479 interactions. According to these date the genes encoding Interleukin-10 (IL10), Toll-like receptor 4 (TLR4), and catalase (CAT) have the highest priority in the development of asthma and arterial hypertension comorbidity.
In current research we demonstrate the influence of IL10 knockdown on development of experimental comorbidity of asthma and hypertension. RNA-interference of IL10, a gene predicted by ANDSystem, affected cardiovascular as well as respiratory functions are changed in spontaneously hypertensive rats with ovalbumin-induced asthma.
All procedures followed the criteria, technical standards and rights applied to animal research. All trials were followed in accordance with the statements of the European Union regarding the handling of experimental animals. This investigation conformed to the laws and local ethical committee guidelines for animal research.
Spontaneously hypertensive male rats (SHR) aged 4–5 months (body mass 300–350 g) used in our study, were purchased from “Charles River Laboratories” company. Prior to experiments, rats were maintained in an animal facility under standard laboratory conditions for 3 months with free access to food and water. Hypertensive status was confirmed by measuring the blood pressure using non-invasive Mouse-Rat Blood Pressure Monitor – CODA (Kent Scientific, USA) before the start of the experiments. All measurements were provided after 10 min holding non stressed animal in special cage. Only animals with a systolic pressure 190.1 ± 17.62 mmHg and diastolic pressure 133.7 ± 22.7 mmHg were taken to experiment. Rats were randomly divided into three groups: control group, ovalbumin (OVA)-induced asthma group + scrambled shRNA-producing plasmid group; OVA-induced asthma + anti-IL10 shRNA-producing plasmid shRNA interference group. Each group included seven rats.
We established asthma model according to the methods of Li and Vanacker ,  with some modifications. Rats were sensitized by intraperitoneal injection of 1 mg OVA (S7951, Sigma-Aldrich, USA) adsorbed to 0.3 mL of Al(OH)3 as an adjuvant (Aluminum hydroxide Gel, colloidal suspension, Serva, Germany) in a total volume of 0.8 mL sterile normal saline solution on days 1 and 8. Then starting from the day 15, rats were challenged by intranasal exposure to 100 μL of 1% OVA (in normal saline) once a day for 7 days. The control group was treated only with normal saline injections and intranasal delivery of saline solution. Euthanasia (1.5 g/kg urethane, intraperitoneally) was performed 1 day after the last intranasal delivery.
shRNA sequence complementary to site on IL10 mRNA was designed in silico by siDESIGN Center (Dharmacon, a Horizon Discovery Group Co). We used BLAST (NCBI NIH, USA) algorithm to check it for unspecific binding. For 21 nucleotide RNA sequence, we generated 55 nucleotide sense and antisense oligonucleotides designed according to the recommendation of pSilencer 4.1-CMV neo vector kit (Ambion, ThermoFisher Scientific, USA) of with restriction sites for HindIII and BamHI to obtain sticky ends. These oligonucleotides were synthesized by Metabion, Germany. Sequences of both oligos are presented in Table 1. Two oligos were annealed and then immediately ligated into pSilencer 4.1-CMV neo vector (Ambion, ThermoFisher Scientific, USA). Ligation mix was transformed into chemically competent XL E. coli cells. Single colonies from solid LB agar medium were cultivated in LB broth overnight. Up to 5 mg of plasmid DNA was purified with GeneJet Miniprep Kit (ThermoFisher Scientific, USA) from each colony to screen for successful ligation transformants. Ligation was confirmed by restriction analysis with HindIII and EcoRI and further electrophoresis analysis. Confirmed colonies were cultivated to make preparation-size purifying of shRNA vector. We used GeneJet Maxiprep Kit to obtain up to 1 mg of pDNA which was dissolved in sterile endotoxin-free deionized water (ThermoFisher Scientific, USA) in sterile conditions and was ready for further experiments. The same procedure was performed for scrambled shRNA-encoding plasmid.
|IL10, NM_012854.2||Top: 5′-GATCCGCTGAAGACCCTCTGGATACATTCAAGAGATGTATC CAGAGGGTCTTCAGCA-3′
Bottom: 5′-AGCTTGCTGAAGACCCTCTGGATACATCTCTTGAATGTA TCCAGAGGGTCTTCAGCG-3′
|Scrambled||Top: 5′-GATCCTTCTCCGAACGTGTCACGTTTCAAGAGAACGTGACA CGTTCGGAGAAA-3′
Bottom: 5′-AGCTTTTCTCCGAACGTGTCACGTTCTCTTGAAACGTGA CACGTTCGGAGAAG-3′
For IL10 knockdown in vivo, 100 μg of the anti-IL10 shRNA-expressing plasmid was injected to rats via the tail vein on the 15th day after the first injection of OVA. The same dose of scrambled plasmid was injected to the rats of the control group.
The effectiveness of RNA interference was measured using real-time PCR in the heart tissue.
Total RNA was isolated with Trizol reagent (Invitrogen, USA) reagent. RNA concentration was determined using the NanoDrop spectrophotometer ND1000 (NanoDrop Technologies Inc, USA). cDNA was synthesized from 5 μg of total RNA by reverse transcription with 10 mM Tris-HCl (pH 9.0), 5 mM MgCl2; 1 mm dNTPs; 20 U Ribo-Lock, Random hexamer primers (0.5 μg/μL) and 200 U RevertAid H Minus M-MuLV Reverse Transcriptase. PCR was performed using the Applied Biosystems 2700, PerkinElmer, USA. Gene expression of IL-10 (Custom TaqMan® Gene Expression Assays, Rn01483988_g1) was determined using TaqMan® Gene Expression Assay (“Applied Biosystems”, USA). The pairs of forward and reverse primers for above mentioned genes and the TaqMan probes for the target mRNAs were designed based on the rat mRNA sequence by Applied Biosystems (USA). Gene expression in each probe was normalized by GAPDH, using TaqMan Rodent GADPH Control Reagent (VIC™Probe, lot number 0608014). The thermal cycles of PCR amplification were the following: initial denaturation step at 95 °C for 20 s, followed by 60 cycles of treatment at 95 °C for 3 s, and at 60 °C for 30 s using 7500 Fast Real-time PCR (Applied Biosystems, USA). Analysis of obtained data was carried out with 7500 Fast Real-time PCR Software.
The evaluation of hemodynamic parameters was performed as described previously . Briefly: rats were anesthetized with urethane (1.5 g/kg, intraperitoneally), fixed, and the right carotid artery was dissected. An ultra-small catheter 2F (Millar Instruments, USA) was introduced retrogradely through the right carotid artery and the signals of pressure and volume in the left ventricle during the cardiac cycle were simultaneously recorded with visualization of P–V curves. Recordings of the cardiodynamic parameters were performed in two modes: in an initial state and during temporary occlusion of the abdominal vena cava (for 7–10 s). We recorded the following cardio-hemodynamic parameters: heart rate (HR), end-systolic pressure (ESP), end-diastolic pressure, end-systolic volume of the left ventricle (ESV), end-diastolic volume of the left ventricle (EDV), stroke volume, cardiac output, ejection fraction, dP/dt max, dP/dt min, dV/dt max, dV/dt min and PdVdt max. Effective arterial elastance, determined according to the data of Sunagawa, was calculated as the ratio of ESP derived from the pressure-volume curve in the initial state to stroke volume. The pressure and volume ratio in the left ventricle was analyzed using the PVAN 3.6 program (Millar Instruments, Gulf Fwy, Houston, USA) with the conversion of relative volume units (RVU) to absolute units of volume (μL) using the data acquired during calibration procedure performed according to manufacturer recommendations formula (slope 20.25 × RVU-intercept 29.05).
Measurements of respiratory system resistance and compliance were measured using a SciReq FlexiVent ventilator (Scireq, Montreal, PQ, Canada). Briefly, 24 h after final challenge, animals were anaesthetized (urethane, 1.5 g/kg), tracheotomized (19Fr blunt Luer cannula), and connected to the ventilator. Animals were maintained at 37 °C and, under muscle paralysis (Atracurium-Novo, NovoPharm Biosynthes, Ukraine). Aerosol challenge was performed after four successive baseline measurements using solutions of 4, 8, 16, 32, or 64 mg/kg metacholine (MCh, A2251, Sigma-Aldrich, USA) or saline (as a control). All the mentioned solutions were delivered for 60 s each by an ultrasonic nebulizer (Aeroneb Pro, ANP-1100, Aerogen Ltd, Ireland) via the inspiratory port of the respirator. Before each delivery, two inspiratory phases were superimposed to standardize the volume history. Measurements were started 20 s after completion of each aerosol challenge, and eight successive recordings were collected during every 20 s. The next dose was administered 60 s after the last recording. Resistance (cmH2O*s/mL) and compliance of respiratory system (Crs, mL/cmH2O) were calculated using FlexiWare 7.4 software (Scireq, Montreal, PQ, Canada).
After insertion of a catheter into the trachea, the lungs of the animal were lavaged with 1.5 mL of Hanks balanced salt solution (Invitrogen, USA) . The lavage fluid was centrifuged at 250 g during 3 min, and the cell pellet was resuspended in 1.5 mL RPMI (Invitrogen) and the total cells were counted under a microscope (Olympus, Japan). The cells were then fluorescence-labeled for flow cytometric analysis in order to detect the percentage of T2 helpers in BALF. First of all, samples were incubated in RPMI 1640 for 4 h with ionomycin (1 μg/mL), brefeldin-A (10 μg/mL), and 25 ng/mL phorbol 12-myristate 13-acetate (all from Sigma, St Louis, MO, USA). Cells were washed by PBS and pellets were resuspended in 100 μL PBS and stained with fluorescein isothiocyanate (FITC)-conjugated anti-CD4 (554837, Becton Dickinson, San Diego, CA, USA) for 30 min. The cells were lysed (Lysing Solution; BD Biosciences), permeabilized (Permeabilizing Solution; BD Biosciences), and stained with fluorochrome-conjugated mAbs. Cell pellets were resuspended in PBS and stained with fluorescein isothiocyanate (FITC)-conjugated anti-CD4 (554837, Becton Dickinson, San Diego, CA, USA) and R-phycoerythrin-conjugated anti-IL4 (555082, Becton Dickinson, San Diego, CA, USA) antibodies. The samples were stained for 30 min at room temperature in the dark. Then the cell suspensions were centrifuged, and the cell pellets were resuspended in PBS containing sodium azide and paraformaldehyde. Then, the cells were analyzed with the FACSCalibur flow cytometer (BD Biosciences, USA) equipped with CellQuest software (BD Biosciences, USA) .
For light microscopic study, lung specimens were fixed in 10% buffered formalin and 5-mm thick paraffin sections were prepared and stained with hematoxylin and eosin (H&E). H&E-stained tissue sections were examined light-microscopically with Nikon Eclipse E200 microscope and Nikon DS-SI 1 camera and analyzed by using the ImageJ software. Morphometric measurements were made in lung tissue samples of five rats from each experimental group (in 10 nonoverlapping microscopic fields for each rat). The area of infiltrates content was measured at a magnification of ×100 for each specimen and was expressed as a percentage relative to the area of the standard measuring frame.
The structural changes in the bronchiole walls of different size were analyzed as described previously . The total bronchial wall area (WAt = Ao – Abm), the inner wall area (WAi = Amo – Abm) and the outer wall area (WAo = Ao – Amo) were calculated based on the measured values of the basement membrane length of the epithelium (Pbm), the perimeter of the outer boundary of the smooth muscle (Pmo), the outer adventitial perimeter (Po) and the areas defined by these parameters (Abm – basement membrane area, Amo – outer muscle area and Ao – outer airway area). The studied airways in each experimental group of rats were divided into two categories according to the length of their basement membrane: Pbm < 1 mm (small), 1 mm ≤ Pbm < 2 mm (medium). For analysis of the morphometric measurements the values of WAt, WAi, WAo, were normalized to Pbm.
All data were checked for normality of distribution using Shapiro-Wilk normality test. Difference between groups was estimated using the Kruskal-Wallis rank sum test. Results were considered statistically significant if p < 0.05. In cases when more then two groups were compared Kruskal-Wallis was followed by Dunn’s test of multiple comparisons and the null hypothesis was rejected if p ≤ 0.025.
Intravenously injection of IL10-specific shRNA-expressing plasmid induced a 28.6-fold downregulation of the IL10 mRNA level in the thymus and in 5.3-fold in spleen tissues (p < 0.05) compared with scrambled shRNA-expressing plasmid (Figure 1).
Basic parameters of heart function that were estimated using microcatheterisation of the left ventricle are presented in Table 2. In rats with OVA-induced asthma the next indicators were significantly lower than in control: heart rate, maximum volume, minimum volume, end-systolic volume, end-diastolic volume, Tau_w, but at the same time the main parameters of pump function were higher – stroke volume (on 27%, p < 0.05) and ejection fraction (on 63%, p < 0.05). Rats treated with anti-IL10-shRNA-expressing plasmid demonstrated difference of the same parameters with more pronounced elevation of stroke volume (on 45%, p < 0.05) and ejection fraction (on 76%, p < 0.05). Moreover, cardiac output (on 17%, p < 0.05), stroke work (on 1.9-fold, p < 0.05), maximal power (on 1.83-fold, p < 0.05) and main indicator of contractility Emax (on 3.1-fold, p < 0.05) were significantly higher in this group compared to control rats. Knockdown of IL10 gene in asthma modeling in SHR induced the decrease of arterial elastance on 34% (p < 0.05) that showed the decrease of the arterial vessels resistance. Time of diastolic relaxation (Tau_w) of the heart was also decreased in these animals (on 34% compared to control, p < 0.05).
|Parameter||Control||OVA-induced asthma||OVA-induced asthma + IL-10 RNA interference|
|Heart rate (beats/min)||397.4 ± 1.51||294.5 ± 48.96a||315.6 ± 21.89a|
|Maximum volume (μL)||586.4 ± 24.03||450.7 ± 24.03a||482.7 ± 81.79a|
|Minimum volume (μL)||399.8 ± 23.01||248.1 ± 100.0a||211.2 ± 66.15a|
|End-systolic volume (μL)||415.9 ± 18.74||271.9 ± 105.36a||237.3 ± 74.33a|
|End-diastolic volume (μL)||565.7 ± 25.55||423.7 ± 82.09a||453.9 ± 110.06a|
|End-systolic pressure (mmHg)||110.5 ± 4.17||109.6 ± 20.99||102.8 ± 21.23|
|Stroke volume (μL)||186.6 ± 7.01||236.3 ± 51.61a||271.5 ± 78.02a|
|Ejection fraction (%)||31.9 ± 1.49||52.3 ± 16.0a||56.2 ± 6.61a|
|Cardiac output (mL/min)||74.2 ± 2.79||70.7 ± 17.31||86.86 ± 30.199a|
|Stroke work (mmHg/μL)||13430.11 ± 1337.55||17635.03 ± 8629.781||25994.59 ± 12651.43a,b|
|Arterial elastance (mmHg/μL)||0.59 ± 0.032||0.50 ± 0.13||0.39 ± 0.074a,b|
|dPdt max (mmHg/s)||5790.3 ± 221.40||8287.1 ± 4636.45||14102.7 ± 5770.27|
|dPdt min (mmHg/s)||−6640.8 ± 146.81||−5640.5 ± 1786.94||−6170.3 ± 791.73|
|Tau_w (ms)||15.8 ± 0.92||10.4 ± 1.91a||9.97 ± 1.59a|
|Tau_g (ms)||13.8 ± 0.35||16.3 ± 5.74||18.8 ± 6.87|
|Maximal power (mW)||89.6 ± 13.76||112.2 ± 61.35||164.3 ± 73.81a|
|Emax||2.79 ± 0.29||8.02 ± 7.28||8.77 ± 5.45a|
aMeans are statistically different against control group. bMeans are statistically different against asthma group.
In control rats baseline resistance was 0.21 ± 0.036 and slightly increased substantially with methacholine from 0.43 ± 0.041 to 1.67 ± 0.077 cmH2O*s/mL (Figure 2A). In OVA-induced asthma group baseline resistance was 3.8 times higher (p < 0.05) comparing to this parameter in control animals, and increased to a greater extent with methacholine from 0.81 ± 0.092 to 1.44 ± 0.083 with maximal differences during the methacholine treatment in doses 0 and 4 mg/kg – 1.9-fold and 1.4-fold correspondingly (Figure 2A; p < 0.05). The baseline resistance was 2.6 times higher compared to control (p < 0.05) in asthma + IL10 shRNA-interference group, but it was significantly lower compared to the asthma group. During methacholine challenge the resistance increased from 0.75 ± 0.035 to 1.17 ± 0.071 with differences in methacholine doses 8 and 32 mg/kg – 1.5-fold higher and on 19% lower correspondingly compared to OVA-induced asthma group (Figure 2A).
Compliance of respiratory system (Crs) in control rats were 4 times (p < 0.05) higher compared to OVA-induced asthma group, and was decreased from 0.2 ± 0.012 to 0.08 ± 0.007 mL/mmH2O (Figure 2B). In OVA-induced asthma group Crs was decreased from 0.06 ± 0.004 to 0.04 ± 0.003 in methacholine test with maximal differences in methacholine doses 0, 4, 16 and 32 mg/kg (p < 0.05). RNA-interference significantly influenced on Crs baseline compared to OVA-induced asthma group (0.11 ± 0.009 and 0.06 ± 0.005 correspondingly, p < 0.05). During methacholine challenge Crs was decreased in asthma + IL10 shRNA-interference group more prominent than in OVA-induced asthma group (from 0.1 ± 0.008 to 0.06 ± 0.004). Significant differences were determined in methacholine doses 0 and 32 mg/kg compared to OVA-induced asthma group (p < 0.05).
Thus, knockdown of IL10 gene prevents asthma-induced negative changes in baseline parameters of resistance and compliance and ameliorates the decline of compliance during experimental bronchoconstriction (methacholine application).
In modeling of OVA-induced asthma the quantity of T-helper 2 cell population in BALF was increased in 2.5-fold (p < 0.05) compared to control (Figure 3). In rats with RNA interference of IL10 the percentage of T-helper 2 cell presence in BALF was slightly lower compared to OVA-induced asthma group (p > 0.05).
The lung sections from the control rats were predominantly showed the normal histological architecture of the lung, these samples exhibited only thin interalveolar septa. The wall of bronchioles was contoured by single-layer of ciliated cuboidal epithelium and a thin layer of smooth muscle fibers (Figure 4). However, slight thickening of the interalveolar septa and negligible peribronchial infiltrates were observed locally in some samples, which can be explained by early manifestations of hypertension in the line of investigated rats (SHR).
In lung sections of rats with OVA-induced asthma the total bronchiole wall was to thicker mostly as a result of peribronchial edema and mononuclear infiltration, bronchial mucosal hyperplasia, as well as increased bronchial smooth muscle mass. Some bronchioles showed intrabronchial cellular debris associated with desquamated epithelium and macrophages. The thickening of interalveolar septa due to red blood cells (RBCs) and mononuclear cellular infiltration, the focal extravasated RBCs in the alveolar spaces up to the collapse of some alveoli with dilatation and ruptures of others, the dilated and congested blood vessels with perivascular edema were observed (Figure 5).
The IL10 RNA-interference to some extent attenuated inflammatory process in the lung tissue (Figure 6 and Figure 7), and we observed mild alveolar and peribronchial inflammatory cellular infiltration as well as some reduction of thickness of interalveolar septa were shown. The parameters that characterize the airway wall remodeling were slightly reduced both in small and medium bronchioles compared to asthmatic group of animals (Figure 8 and Figure 9).
Modeling of comorbid pathology is not routine technique and we have found only few publications in this area. According to our knowledge, we are the first to develop an experimental model of bronchial asthma and arterial hypertension comorbidity presented in the current paper. Earlier Gilmour et al.  demonstrated the susceptibility of SHR to the increased inflammation in the lungs while exposed to particle matter compared to Wistar Kyoto rats due to activation of TLR4-mediated signaling. Kodavanti et al.  has proved that SHR is a better model for experimental bronchitis, because the sulfur dioxide induces marked immune dysregulation, oxidative stress, impairment of cell signaling, and fatty acid metabolism in SHR compared to Sprague Dawley rats.
Here we provide the data experimentally confirming functionality of the target (IL10) which was in silico predicted to be associated with both asthma and hypertension was confirmed in the experimental model of this comorbid pathology. IL-10 is the well-known cytokine participating in the inflammation of different genesis, can block NF-κB activity and is involved in the regulation of the JAK-STAT signaling pathway. These pathways are involved in both asthma and hypertension pathogenesis. We showed that during RNA-interference of IL10 gene in vivo changes both cardiac and lung function parameters. These changes in the heart work can be described as a positive. But the more intensive heart work (the increase of cardiac output, minute volume, heart work, etc) can lead to exhaust and decompensation of the heart functions comparing to control rats. Knockdown of IL10 gene in asthma modeling induces some positive changes in respiratory functions of asthmatic animals such as decreased elastance and increased compliance of the lungs, as well as less pronounced pathomorphological changes in the lung tissue (for example, the thickness of small and medium bronchioles, characterized bronchial asthma). These data are surprising due to the known function of IL10 as anti-inflammatory cytokine ,  and the decrease in its expression was expected to facilitate asthmatic changes in the lungs. It could be explained by the compensatory increase in the production of other anti-inflammatory substances with stronger effects. Moreover, the present investigation is concerned only the early signs of asthma (the challenge with OVA for only 7 days), and the negative consequences of IL-10 knockdown could appear later. This point definitely needs further investigation. But according some data ,  systemic administration of IL-10 for autoimmune therapy proved to be paradoxically proinflammatory. Intravenously plasmid injection in our experiments induces systemic effect also and some positive changes in respiratory parameters in rats with OVA-induced asthma are logically in this context.
Thus, some positive changes in the asthma development in SHR lead to the overload of heart and increases its function, we do not think that decrease of IL-10 level or influence on its receptors is the perspective mechanism for the development of new therapeutically approaches for the treatment of asthma and hypertension comorbidity treatment. Still the new model for comorbidity, developed and described in this work can be useful for the further search of other targets.
This study was supported by the Volkswagen Stiftung Trilateral Partnerships – Cooperation Projects between Scholars and Scientists from Ukraine, Russia, and Germany “In silico screening and experimental validation of new drug targets for the treatment of co-morbid multifactorial diseases” (# 90335).
Conflict of Interest Statement: Authors state no conflict of interest. All authors have read the journal’s Publication ethics and publication malpractice statement available at the journal’s website and hereby confirm that they comply with all its parts applicable to the present scientific work.
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This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

domain: medical


text:
*INdea, a great rich Countrie, called in English Indv, lieng on the South part of ye world, which as Ptholomeus wri∣teth, is diuided into two parts. The one is called Indie within the riuer of Gan∣ges, which on the west is bounded with Aracosia and Gedrosia: on the East, hath the great riuer called Ganges: on the North with the hill called Imaus: on the South and West, with parte of the Indian sea. The other part of Indie wt∣out Ganges, is bounded on the west with the sayd riuer Ganges: on the North, with part of Scythia and Setica: on the East with the Region called Sinaruni: on the South with the Indian sea.
Nearchus, great Alexanders Admirall, affirmed (as A••anus writeth) that it was foure months iourney by ye plaines of Indie, Megasthenes saite, that the breadth of Indie, from the East to the west, cōtaineth 16000. furlongs, which is 2102. miles. The length frō ye North to the South 22000 furlongs, which is 2850. miles. Caesias affirmeth it to bee as much as the residue of Asia: but O∣nesicritus which wrote the actes of A∣lexander, denieth it to be the third parte of Asia. There are alwayes two Sum∣mers, and fruites and graine twice ga∣thered. The windes be alwayes tem∣perate, the beastes and Fowles much greater, than in other Countreyes, and of more diuers kindes. The names of the Countreyes and Cities there, be now otherwise, than they were in the time of the auncient Writers. They which bee now knowen, shall bée de∣clared in their places, with the moun∣tants and riuers which are great aboue all other.
(*Of the thrée principall riuers in In∣die, Ganges, Indus, and Hyphasis: Ganges, a great Riuer that diuideth Indi, called in holye Scripture Phi∣l••. one of the foure riuers which come soorth of Paradise. Iosephus doth in∣terpert if Inundation The bredth ther∣of (as Soho•s writeth) is in the nar∣rowest place eight miles, in the brodest, twentie miles. Ananus writeth, that where it is narrowest, it is in bredth one hundred furlongs, which is eight miles. In many places, it spreadeth so wide, that where the gerunde is most plaine, nor any high place appeareth, no man may discerne anye thing of the o∣ther side: in the shallowest place, it is an hundred foote deepe. There runneth into it, seauenteene great Riuers, euerye one of them able to beare a shippe. In this Riuer of Ganges is an Ile, and therein a great Citie, called Palibetia, the Country is called Phrasia, the king whereof as Plyme writeth lib. 6. cap. 19. hath alwayes in wages 600000. foot-men, 30000. hors-men, and 9000. Elephants.)
(*Indus is a notable Riuer, that commeth from the great Mountaine Taurus, and incleaseth Indie on the West, and runneth into the Indian sea. Into this Riuer runneth nineteene great and famous Riuers, the least of them is more, than the great Riuer of Donowe. Where he is broadest, Stra∣bo sayeth, that they which doe write most moderately of Indus, doe affirme, that he is in breadth fiftie furlongs, which is twelue miles and a halfe. The water thereof causeth great fertilitie, when it ouerfloweth, and thereof many sundry pleasant and wholsome fruites, doe spring without labour.)
(*Hypasis, or as some doe write, Hypanis, Arianus calleth it Hyphasis, a great Riuer, which runneth out of the mountaines of Scythia into Indie, and commeth into the famous riuer of Gan∣ges, and is in breadth seauen furlongs, as Diodorus writeth, libro. 17. The streame thereof is so swifte, that no man may passe euer it, by the space of fiue dayes sayling. The water is fresh: af∣ter that it commeth within foure daies sailyng of the sea, it is wonderfull bit∣ter, by reason of a bitter Fountayne, which runneth into it. At this Riuer, the great Alexander finished his iour∣ney, and went no farther into Indie, but did there set vp twelue Altars of Stone, euerye of them fiftye Cubites Page [unnumbered] in greatnesse. D. Cooper.

domain: geography


text:
Topband: Followup on the 1915kHz radar signal
Gary at ka1j.com
Mon Dec 15 14:38:51 EST 2014
Nice find, Doug, it sure is a strong
signal. With my 3 el HI-Z I couldn't guess
the direction in any real accuracy but I
had a feeling from the stronger NE
signals, it was NE & following the
coastline from my QTH on the ocean in SE
CT. Indeed NS is right in that line from
here at 50 degrees north.
Nice to know that the HI-Z is not only
well directional but is seemingly oriented
As far as the signal itself, the military
obviously trumps the civilian needs and I
guess we can be glad it doesn't drift
around like the woodpecker did.
> After some Googling and educated guessing, I have determined (and
> received confirmation of) the following:
> - It is a high-frequency surface-wave radar (HFSWR) system, developed
> by Raytheon Canada for the Canadian military. It seems to be a new
> version of the SWR503 MK2 HFSWR system. It is intended to detect ships
> up to 200 miles from a country's coast (EEZ) to protect against
> terrorists, smugglers, and unauthorized fishing vessels as well as
> locate vessels in distress. The present system has been detected at
> 1915, 3250, 4400, and 5300 kHz.
> - It is located at Hartlen Point, NS, near Halifax
> (point Google Earth to 44 35 29.47 N 63 26 49.68 W )
> and if you zoom in you can see the 500M long cleared area for the
> towers and the guy anchors.
> - W1FV was pretty close with his estimate of a heading of 75 degrees
> (it is actually 67 degrees from John's QTH).
> - ARRL, RAC, and Industry Canada (Canada's FCC) have been made aware
> of the interference that this signal is causing to amateurs.
> - The frequency band 1850-2000 is a shared allocation in Canada, among
> amateur, radionavigation, and radiolocation services.
> - A previous version of this system was installed in several other regions.
> 1915 kHz is not the primary operating frequency for the system. The
> higher frequencies generally work better for the intended purpose.
> So the mystery is solved...at least as far as the source is concerned.
> Doug K1DG
> Topband Reflector Archives - http://www.contesting.com/_topband
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More information about the Topband


text:
Estimated read time: Less than a minute
This archived news story is available only for your personal, non-commercial use. Information in the story may be outdated or superseded by additional information. Reading or replaying the story in its archived form does not constitute a republication of the story.
WEST LIBERTY, W.Va. (AP) — West Liberty University athletic director Jim Watson is stepping down after serving for more than two decades.
West Liberty officials announced on Wednesday that Watson will retire on June 30.
Interim president John McCullough says assistant men's basketball coach Aaron Huffman has been named interim athletic director, effective July 1. Huffman also is an assistant professor of physical education and health.
Watson has served as West Liberty's athletic director for 26 years. He has been employed by the university since 1971, when he was hired as head baseball coach and athletic trainer.
The Hilltoppers won five consecutive West Virginia Conference baseball championships during Watson's 11 seasons as coach. That's a league record.
Copyright © The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


Fiocchi Shooting Dynamics 60 gr Jacketed Hollow Point .32 Auto Ammo, 50/box - 32APHP
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- Bullet Style: Jacketed Hollow Point
- Caliber/Gauge: 32 Auto
- Bullet Weight: 60 grain
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- Application: Performance/Protection
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- Ballistic Coefficient: 0.12
The philosophy behind the Pistol Shooting Dynamics Line is very simple: focus on the achievement of the ideal synergy between shooter, firearm, and ammunition. Fiocchi keeps developing and improving its pistol and revolver cartridge products. It encompasses LRN, FMJ, JHP, FMJHP, and JSP bullet configurations in all the most popular calibers.


On October 14, 2023, the City of Terrace finalized and recognized a generous land donation from the Pousette family by holding a brief event at a new memorial bench placed in John Pousette’s honour. The land donation was for a parcel on the escarpment slope between Skeenaview Drive and Howe Creek. The memorial bench is located on the Howe Creek Trail, next to Parkside School at the northwest corner of Christie Park.
The reason the family owned this unusual piece of land is part of the story of John Pousette and his family’s rich ties to the Terrace community.
John Pousette grew up in Blind River, in northern Ontario. He was a WWII veteran who served with the 48th Highlanders. After graduating from UBC with a law degree, he articled as a lawyer in Prince Rupert. John’s wife, Evelyn, also attended UBC. After graduating, she worked as a schoolteacher in Prince Rupert, where she and John met.
In 1954, the Pousettes moved to Kitimat where John worked for Alcan as their corporate lawyer. The land the family has donated to the City was a 3.5-acre property encompassing mainly a steep slope. John bought the land while still living in Kitimat so he could vote in Terrace municipal elections, as he had to own property in the community to do so.
The family (John, Evelyn, and their three children) moved to Terrace in 1962 where John first worked for the Murdoch (Doc) Robertson law firm before becoming the administrator for the municipality of Terrace. When the Regional District of Kitimat-Stikine was created in 1968/69, John became its first administrator and worked there until he retired. Evelyn worked for many years as a schoolteacher and librarian in Terrace.
On this sunny October day, City of Terrace staff accompanied Evelyn, now 93, and her daughter Ruth on a walk to the memorial bench. Evelyn was touched by the tribute to her late husband, who passed away in 2018.
The City of Terrace thanks the Pousette family for their contributions to the community, including this land donation. Please enjoy the bench the next time you’re walking Howe Creek Trail!


text:
Bihar CEO Ajay V Nayak said, “Prima-facie the Saran district administration is not at fault. The EC, too, will concur with it.”
Rabri’s husband Lalu Prasad, who was following her vehicle, had prevented officials from checking the car. Prasad is also alleged to have misbehaved with the raiding party. The EC had sought a report from the Saran DM over the incident. The DM submitted the report on Monday.
Following the incident, Rabri had lodged a complaint with the poll. She had alleged that standard operating procedures were not followed during vehicle-checking, which was done as part of EC’s guideline on expenditure monitoring.

domain: law


text:
Men's wages before and after long-term unemployment spells
September 06, 2013
Men experiencing their first long-term unemployment spell—a spell lasting 27 weeks or longer—saw a sharp decrease in their average hourly wage in the calendar year before that long-term unemployment spell. In the year the first long-term unemployment spell started, the average hourly wage was about 13 percent lower (adjusted for inflation) than the average hourly wage 2 years before the first long-term spell.
|Year||Hourly wage index|
4 years before
3 years before
2 years before
1 year before
year of onset of spell
1 year after
2 years after
3 years after
4 years after
In the first calendar year after onset of the first long-term unemployment spell, real average hourly wages continued to fall by about 4 percent. Average hourly wages then trended back up in the following years. However, real average hourly wages were about 7 percent lower 4 years after the onset of the long-term unemployment spell than they were 4 years before the long-term spell.
In contrast, men who did not experience a long-term unemployment spell had very significant wage growth over time. For example, over the 8-year period from 1990 to 1998, men who never had a long-term unemployment spell experienced a 41-percent increase in their real hourly wages, on average.
These data are from the National Longitudinal Surveys program. To learn more, see “Long-term unemployment over men’s careers,” (HTML) (PDF), by Donna S. Rothstein in Beyond the Numbers, August 2013. The article uses the employment history of men in the National Longitudinal Survey of Youth 1979 (NLSY79). The men in the NLSY79 were born in the years 1957 to 1964. The analysis covers the mid-1980s through 2009, focusing on men’s employment histories from their mid-20s, after they had become integrated into the labor market, until their middle to late 40s and early 50s.
Bureau of Labor Statistics, U.S. Department of Labor, The Economics Daily, Men's wages before and after long-term unemployment spells on the Internet at http://www.bls.gov/opub/ted/2013/ted_20130906.htm (visited May 24, 2016).
Recent editions of Spotlight on Statistics
Employment and Wages in Healthcare Occupations
Healthcare occupations are a significant percentage of U.S. employment. Some of the largest and highest paying occupations are in healthcare. This Spotlight examines employment and wages for healthcare occupations.
Fifty years of looking at changes in peoples lives
Longitudinal surveys help us understand long-term changes, such as how events that happened when a person was in high school affect labor market success as an adult.
- A look at pay at the top, the bottom, and in between
The Spotlight examines how earnings and wages have changed over time and how they differ within a geographic area, industry, or occupation.

domain: sociology


Nearly 20 years after its final flight, Concorde continues to capture the imagination of many aviation enthusiasts as the most remarkable airplane in history: a brilliant, beautiful marvel of innovation and ingenuity that became the darling of the world’s jet-setting elite.
With the tagline “Arrive Before You Leave” for its ability to fly passengers westward across the Atlantic Ocean in about three hours, Concorde still holds the prestige of being the only commercial supersonic aircraft (though that status could soon be disrupted by several emerging players reviving the sector).
Even so, those lucky enough to have traveled on Concorde say the aircraft will always retain a rarified air not just for its engineering feats—flying more than twice the speed of sound and on the fringes of space, at 11 miles above the ground—but also for an unmatchable aura of thrill and luxury.
“The atmosphere in the cabin was one of an exclusive club, and it was because these were the people who controlled the world, controlled the world’s finance and the world’s trade,” says Joe Cuddy, who worked for nine years on the Concorde fleet as a flight attendant and senior fleet trainer. “It was such an incredibly unique experience, and you were going faster than rifle bullets, twice the speed of sound. It was just a fabulous time.”
Here's what it was like to fly on the iconic aircraft during its heyday—and why it continues to inspire such wonder more than two decades after its retirement.
A first-of-its-kind jet
First things first: Not unlike those A-list celebrities who only go by one name, Concorde, too, stands alone. There’s no preliminary “the” required; it’s simply Concorde.
The moniker, which is the French word for harmony or union, reflects the collaboration between France and Great Britain to develop the world’s first commercial supersonic aircraft, explains Bob van der Linden, the National Air and Space Museum’s curator of air transportation and special purpose aircraft. In the early 1960s, as the U.S. aerospace industry shifted into overdrive as the space race was heating up, the French and British focused on the supersonic sector, joining forces to share the multi-billion-dollar costs of developing a first-of-its-kind commercial aircraft from scratch.


How risky is benzodiazepine use in pregnancy?
Early pregnancy exposure to any benzodiazepine was associated with an increased risk of miscarriage in women, according to a new study published in JAMA Psychiatry.
While previous research has linked pregnancy loss to this class of drugs, study researchers wanted to find out more about the exact risk of benzodiazepine use and miscarriage, which was defined as a pregnancy loss between the beginning of the sixth week and the 19th week of gestation.
Researchers analyzed data from more than 442,000 pregnancies from 1998 to 2015 in the Quebec Pregnancy Cohort, which includes data on all pregnancies of women covered by the Quebec Public Prescription Drug Insurance Plan. They found that the risk of miscarriage was greater when women took an increasing daily dose of a benzodiazepine, and that it didn’t matter which benzodiazepine they were exposed to. Similarly, the duration of action—short-acting and long-acting benzodiazepines—carried the same risk.
In their conclusion, the study authors wrote, “The findings suggest that health care clinicians should carefully evaluate the risk–benefit ratio of benzodiazepines for the treatment of insomnia and mood or anxiety disorders in early pregnancy. Alternative nonpharmacologic treatments exist and are recommended, but if benzodiazepines are needed, they should be prescribed for short durations.”
Authors explained that they at least partially corrected for diagnoses of mood and anxiety disorders and insomnia, as well as exposure to antidepressants and antipsychotics. However, other limitations of the study include tobacco and alcohol use that may not be accounted for.


text:
Daily Kos Elections/Daily Kos Staff reports:Morning Digest: Scramble is on after unexpected retirement opens up Ohio Senate seat.
OH-Sen: In a big surprise, Republican Sen. Rob Portman announced Monday that he would not seek a third term next year in Ohio. Portman, who is 65, had not shown any obvious interest in retirement, and he had a large $4.6 million war chest at the end of September of 2020. The senator, though, explained his decision by saying, “I don’t think any Senate office has been more successful in getting things done, but honestly, it has gotten harder and harder to break through the partisan gridlock and make progress on substantive policy, and that has contributed to my decision.”
Portman’s departure will likely give Democrats a better shot at his Senate seat, but Ohio’s rightward drift over the last few years will still make it difficult for Team Blue to score a win in this traditional swing state. Joe Biden targeted the Buckeye State hard in 2020, but Donald Trump still defeated him 53–45. However, Ohio isn’t a place that Republicans can take victory for granted: Portman’s Democratic colleague, Sen. Sherrod Brown, earned re-election 53–47 in 2018, and last year, Democrats won an officially nonpartisan race for the state Supreme Court.
Republicans, though, have the far larger bench in this state …
See the report for that large bench.
And see this one for more background on Portman: Republican senator’s surprise retirement could give Democrats a pickup opportunity in Ohio from Jeff Singer for Daily Kos Elections.
The OH race will be brutal: Ohio GOP senator announces 2022 retirement, kicking off ‘sh*t show’ cycle for Republicans reports Kerry Eleveld of the Daily Kos Staff.
Republican Sen. Rob Portman of Ohio announced Monday that he would not be running for reelection in 2022, setting up a raucous GOP primary for the open Senate seat. For instance, a relatively sane GOP conservative like Lt. Gov. Jon Husted could go to head-to-head with staunch pro-Trumper seditionist Rep. Jim Jordan.
“Well, this will be a total shit show,” one Ohio Republican strategist texted to BuzzFeed reporter Henry Gomez.
In fact, Ohio is just one of a handful of places where a “total shit show” could play out for Senate Republicans as Trumpers go to battle for open seats in states where Democrats have real pickup opportunities. That includes North Carolina and Pennsylvania, where GOP Sens. Richard Burr and Pat Toomey respectively have already announced their retirements. Other states that might see high-profile retirements include Iowa, a seat now held by Sen. Chuck Grassley, and Wisconsin, where current sitting senator Ron Johnson has yet to announce his plans. Republicans have already been devoting considerable energy to trying to talk 89-year-old Grassley into running for an eighth term—that’s how bad their map is.
In fact, this tweet from conservative journalist Josh Kraushaar about sums it up.
Josh Kraushaar @HotlineJosh
Nightmare scenario for Senate Rs;
PA GOP nominee: Scott Perry (https://nytimes.com/2021/01/23/us/politics/scott-perry-trump-justice-department-election.html…)
NC GOP nominee: Lara Trump (https://cnn.com/2020/12/16/politics/lara-trump-north-carolina-senate-mark-walker/index.html…
AZ GOP nominee: Kelli Ward (https://wsj.com/articles/arizona-gop-censures-cindy-mccain-doug-ducey-re-elects-kelli-ward-as-chair–11611453988…)
OH GOP nominee: Jim Jordan (https://cincinnati.com/get-access/?return=https%3A%2F%2Fwww.cincinnati.com%2Fstory%2Fnews%2Fpolitics%2Felections%2F2021%2F01%2F25%2Fwhich-republican-might-replace-ohio-u-s-sen-rob-portman%2F6698169002%2F…)


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This Is Not a Love Song (2002)
Critic Consensus: No consensus yet.
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Yes, it is.
While digital video often is employed by filmmakers to no real aesthetic end beyond its speed, technical simplicity and reduced cost, in "This Is Not a Love Song," British director Bille Eltringham harnesses its creative possibilities, along with a variety of experimental techniques, to bring emotional edge, tension and visual texture to a fugitive thriller that could have been standard genre fare.
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domain: artistic


text:
Hari v. Lynch et al
DECISION AND ORDER. The Government's Motion to Dismiss 11 is GRANTED because this case is moot. The Clerk of Court is directed to close this case. SO ORDERED. A copy of this NEF and Order have been mailed to the pro se Petitioner. Signed by Hon. Frank P. Geraci, Jr. on 7/25/2017. (AFM)-CLERK TO FOLLOW UP-
UNITED STATES DISTRICT COURT
WESTERN DISTRICT OF NEW YORK
Case # 16-CV-776-FPG
DECISION AND ORDER
JEFFERSON B. SESSIONS,
Attorney General of the United States, et al.,
Pro se Petitioner Bohara Hari (“Petitioner”) filed this action seeking a Writ of Habeas
Corpus under 28 U.S.C. § 2241. ECF No. 1. Petitioner alleges that he was ordered removed to
Nepal, but he has not been removed and instead has remained in the custody of the Department of
Homeland Security (“DHS”) for over six months pending deportation. Id. Due to this delay,
Petitioner seeks to be released from custody.
The government has moved to dismiss this case as moot because Petitioner has been
released from DHS custody. ECF Nos. 11, 12. Petitioner did not respond to the government’s
“Where an alien challenging his detention under 28 U.S.C. § 2241 is released during the
pendency of his petition under an order of supervision, the petition is rendered moot.” Harvey v.
Holder, 63 F.Supp. 3d 318, 320 (W.D.N.Y. 2014).
Here, the uncontroverted evidence
demonstrates that Petitioner was released from DHS custody on March 20, 2017. ECF No. 11-1,
at 2. Accordingly, this action is moot and must be dismissed.
The government’s motion to dismiss (ECF Nos. 11, 12) is GRANTED because this case is
moot. No certificate of appealability shall issue, because Petitioner has failed to make a substantial
showing that he was denied a constitutional right. The Clerk of Court is directed to close this case.
IT IS SO ORDERED.
Dated: July 25, 2017
Rochester, New York
HON. FRANK P. GERACI, JR.
United States District Court
Disclaimer: Justia Dockets & Filings provides public litigation records from the federal appellate and district courts. These filings and docket sheets should not be considered findings of fact or liability, nor do they necessarily reflect the view of Justia.
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By Qondile Ntiwane | 2019-08-01
The COMESA Secretariat, in collaboration with the African Union Commission (AUC) and the United Nations Development Programme’s (UNDP) Regional Service Centre for Africa will hold a training workshop for Member States on Green/Climate Financing.
The two-day training, also co-hosted by the government of Republic of Zimbabwe, will be held in Harare, Zimbabwe starting today.
According to a statement released by COMESA yesterday, the training aims to strengthen African Union (AU) Member States’ capacities to access, manage and deliver national and international climate finance more effectively, including awareness on the benefits of private sector engagement in climate actions all in support of their Nationally Determined Contributions (NDC) implementation.
The mobilisation of resources will benefit low carbon development, including resilient infrastructure. Experts responsible for resource mobilisation to finance climate change/sustainable related projects will also be in attendance.
It was stated that the participants would be drawn from ministries responsible for finance and National Development Planning, National Designated Authorities for the Green Climate Fund (GCF), the Global Environment Facility (GEF) and the United Nations Framework Convention on Climate Change (UNFCCC) focal persons from the AU Member States. Representatives from the private sector, as well as experts responsible for climate change from Regional Economic Communities (RECs) will also attend. Other participants will include representatives of the African Development Bank (AfDB), the Development Bank of Southern Africa (DBSA), the Commonwealth Secretariat (COMSEC) and the Infrastructure Development Bank of Zimbabwe.
Climate change is an existential threat that is evidently affecting the African continent on a daily basis. Most African countries are witnessing an increase in extreme weather patterns that are linked to disasters resulting in serious humanitarian challenges. Apart from the loss of lives and property, climate-related disasters are reversing development gains and undermining the continent’s efforts to attain the aspirations of Agenda 2063 and the UN 2030 Sustainable Development Goals.
“The continent’s low adaptive capacity makes it more vulnerable to the impacts of climate change.
Filling this gap requires support in the areas of technology, capacity development, skills and finance,” said Dr Mclay Kanyangarara, the COMESA Climate Change Advisor.
“There is not enough knowledge about what constitutes climate and green finance, and options for investments in climate change related portfolios and green sectors. In addition there is also need to increase awareness on the benefits of private sector engagement in climate actions,” added Harsen Nyambe Nyambe, Head of Environment, Climate Change, Water and Land Management at the AUC.
During the workshop, technical experts will present an overview of green/climate finance, NDC financing and the role of the private sector in climate financing. Participants will also be taken through the main avenues to accessing finance for climate action, with a focus on identifying good practices derived from national and international experience. Basically, the training will emphasis on how Africa can improve mobilisation of climate/green finance for sustainable development. Some of the complexities include challenges associated with making bankable adaptation project proposals, cumbersome application processes and procedures, demanding fiduciary requirements, and limited information about existing resources.
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Status: 27.11.2022 00:01
In Venezuela, there has been no dialogue between the government and the opposition for almost a year. This has now changed. Goal: Restoring access to frozen state funds. The US has already withdrawn the first sanctions.
Venezuela’s government and opposition have resumed talks after more than a year and agreed to humanitarian cooperation. Representatives from both sides signed a partial agreement in front of reporters in Mexico City. Among other things, it provides for joint efforts to achieve the release of frozen state funds due to international sanctions to finance emergency social expenditures.
The government and the opposition have adopted a joint application to the United Nations. So the UN should manage a fund to help provide health, food and education to the country’s poor.
The US government eased the first sanctions
At that time, the US government announced that it would ease restrictions on Chevron Oil Company in Venezuela. A senior U.S. official told reporters by phone that the Treasury Department had granted Chevron a temporary permit to allow the U.S. company to resume limited mineral exploration in the South American country.
However, the US government reserves the right to withdraw the easing at any time if Venezuelan President Nicolás Maduro does not negotiate in good faith or fulfill promises.
US, EU and Canadian foreign ministers have welcomed the move
In a joint statement, the foreign ministers of the United States, Great Britain and Canada and EU foreign policy chief Joseph Borrell welcomed the resumption of negotiations and a humanitarian agreement – but not without demands.
We call on the parties to work in good faith for a comprehensive agreement that will lead to free and fair elections in 2024, restore democratic institutions and end the humanitarian crisis in Venezuela.
Venezuela has been in crisis for years
Under Maduro’s authoritarian rule, Venezuela has been in a deep political, economic and humanitarian crisis for years. Opposition leader Juan Guaido declared himself interim president in early 2019 and tried to oust Maduro from office.
Last year, through the mediation of Norway, a dialogue was launched in Mexico The government collapsed two months later in October. The reason was the extradition of one of Maduro’s confidants to the United States.
“Amateur coffee fan. Travel guru. Subtly charming zombie maven. Incurable reader. Web fanatic.”


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Slightly north of centre, Marylebone sits next to some of London’s most loved residential streets. However, it’s not all Michelin starred restaurants and credit card lunches (although there are some of those); the area has a hugely diverse range of places for lunch and dinner – whether you’re splashing out or popping in on your way home.
Marylebone’s favourite place for a maki roll or two, this humble but high taste sushi place has teamed up with Michelin star chef, Kei Kobayashi to bring a French flavour to this year’s Sushi Shop menu. Try a salmon gravlax roll or maki topped with carpaccio of beef in terayaki sauce.
A favourite Italian restaurant and deli, Briciole is the perfect spot for a long lunch, propped up by plenty of the knowledgeable staff’s favourite dishes. How about fennel flavoured sausage with sprouting broccoli or lemon sorbet with Prosecco – this is proper Italian dining.
Cult meat guys Meat Liquor bring the whole slow and low ethos to central London. It’s hip and pretentious (in a trying to be non-pretentious way) but you can’t begrudge its success, the burgers here are legendary – just don’t skip on the deep fried pickles. There’s cocktails, there’s tattoos everywhere and it’s dark and loud and you’ll end up loving it.
Lebanese gets the design makeover at Comptoir Libanais, which adds a touch of the industrial Leon café style to Middle Eastern sharing plates. Plump for mana’esh – Arabic flatbread pizzas, tagines, salads and lots and lots of hummus.
Roti Chai has repackaged Indian food into something more bite-sized and modern with its soul food kitchen for casual bites on communal tables and a more formal dining room – each with their own menus and kitchens. Plump for dishes inspired by street food hawkers and railways stations like Aloo Papri Chaat at the former, or dishes that use tandoor grills like Kerala duck roast in the dining room.
Giorgio Locatelli is one of London’s most loved chefs. Michelin starred Locanda Locatelli has long been his pride and joy: it’s suitable for a posh family evening out or for trying to impress a date. Locatelli has kept the formality of fine dining but it’s still fun here. Don’t miss the ravioli with pheasant and rosemary jus or roast monkfish with walnut and caper sauce and samphire – pizza doesn’t get a look in.
Restaurant, European, Street Food, Vegetarian, Tapas, $$$
Just one reason to love The Providores & Tapa Room is that they have an enormous selection of New Zealand wines (the biggest in Europe). Split between an all day casual dining and café space and a more contemporary restaurant upstairs, this is fusion cuisine at its best. There are pop up exhibitions and its less formal than many Marylebone restaurants. Food wise, downstairs it’s tapas style dishes like confit duck croquettes, five spice plum sauce and miso-baked aubergine, pinenuts, dates, feta, crispy buckwheat and tahini yoghurt; upstairs, try the crispy Dingley Dell pork belly, onion and apple puree, chai spiced parsnips and kohlrabi kimchi.


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Este o doamna maiestuoasa, in tinuta de gala. Imi doresc sa vad hainele imaginate de tine, purtate de femei, pe toate continentele si insulele, Lorena!
This is by far my favourite illustration of yours. (And you did on my birthday! Coincidence? I think not. ;D )
Incredible gown!Love this illustration, darling!xoxox,CC
Imaginea cu piscina este faina, Lorena!
And I was thinking what I will dress at the party tonight ... The little black dress will be perfect ... elegance and simplicity at the same time! I don't think you can fail with a black dress ... ever!Love it!Even if I don't do always I believe that women should wear dresses more often ... put femininity in an exceptional way...
Gorgeous! I love the black dress!
Your illustrations are beautiful! Sometimes all you need is a black dress...and fabulous dinner ;)
Ah, I just love this one. Its one of my favorites. There is something very romantic/pre-raphelatie about it.*kisses* HH
Wow, this is gorgeous!! You are so tallented.
Thank you very much for reading my post and commenting! Your comment is very important to me and will be answered! I hope my post to be an inspiration!


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Sonam Kapoor's Austrian holiday will make you feel the winter chills!
New Delhi: Bollywood diva Sonam Kapoor and her sister Rhea Kapoor are reportedly bonding big time in Austria these days. And, now, the 31-year-old actress has made her fans go green with envy by sharing some of the candid pictures online from her vacation.
From snow-clad mountains to exotic sceneries, the 'Mausam' star is having the time of her life and we are simply lovin' it. Some of the images are so beautiful that they look like a fairytale affair. See for yourself:
On the cinema front, Sonam is currently enjoying the success of her latest release 'Neerja'. She is also working on her upcoming movie 'Veerey Di Wedding'.
The flick will feature Kareena Kapoor Khan and Swara Bhaskar in key roles. It is expected to go on the floors pretty soon.


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Foxconn is best known for being the manufacturing brains behind Apple’s wildly successful iPhone, among other devices, and now it hopes to establish itself in the EV field too.
Overnight the company unveiled two electric cars and one electric bus under the Foxtron marque. These vehicles were developed, and will be built, in partnership with Yulon.
Foxtron is just the latest joint venture for Yulon, Taiwan’s largest car maker, which already manufactures cars in partnership with Nissan and Dongfeng, as well as its own Luxgen vehicles.
The Foxtron Model C crossover will likely be the joint venture’s volume model. Measuring 4.64 metres long, and riding on a 2.86m wheelbase, the Model C can seat up to seven people across three rows of seats.
Thanks, we presume, to the car’s flat underbody, the Model C has a coefficient of drag of just 0.27.
Foxtron claims the Model C can complete the 0-100km/h standard in 3.8 seconds, and will have a range of up to 700km on a fully charged battery.
With a body designed by Pininfarina, the Foxtron Model E will be the company’s flagship luxury sedan. It’s claimed to have up to 560kW, enabling it reel off the 0-100km/h run in 2.8 seconds. Range is said to be up to 750km.
In addition to this, the Model E reportedly has a rear passenger section designed to function as a mobile office with extensive personal device integration.
There’s also a facial recognition system for opening the doors, and “smart windows”.
Also unveiled overnight was the Foxtron Model T bus, which is claimed to have a range of around 400km and a top speed of 120km/h.
The bus is said to meet regulations for operation in Taiwan, and has already undergone strength testing and over 200,000km of endurance testing.
If all goes according to plan, the vehicles revealed today will go on sale in Taiwan from 2023.
It seems likely these cars will be renamed before going on sale given Ford effectively put the kibosh on Tesla’s plans to sell its mainstream electric sedan as the Model E, forcing the Californian automaker to use the name Model 3 instead.
As part of its EV adventure, Foxconn is running along multiple paths: it will build its own cars, build cars for other companies, and provide a ready-to-go EV architecture for automakers to use and customise.
Earlier this year, Foxconn unveiled an “open” EV architecture that it will license out to other manufacturers. It will form the basis of the Fisker Ocean crossover, which will also be built by Foxtron.
More recently, Foxconn bought the Lordstown electric ute factory in Ohio. The plant was formerly owned by GM, and will be used by the Taiwanese tech giant as a manufacturing site for its own platform and vehicles, as well as pickup trucks designed by Lordstown.


By Mike Berube, president and COO, Strata Worldwide
The mining industry has seen an ever increasing availability of safety electronics over the last 10 years. The recent availability of products to detect the proximity of personnel and active equipment to one another has in particular been a major milestone in the prevention of serious injury and deaths in the mining industry. Experience has shown for proximity detection in an underground coal mining application to be effective, however, it is necessary the proximity detection system provide automated command and control of the equipment. This tight integration of systems is not without its challenges. This is especially true in situations when multiple pieces of equipment are in the same vicinity or when machine operators must be positioned on or adjacent to the equipment. System designers strive to minimize occurrences of nuisance alarms and equipment stoppages due to conditions which may be interpreted as safety conditions when, in fact, they are part of typical activity.
Strata, over the past five years, has supplied more than 1,000 proximity detection and collision avoidance systems that have provided static or highly dynamic safety zones on multiple types of equipment operating within close vicinity. The use of variable zones is used in conjunction with direct control over equipment functions. Strata will describe lessons learned, through the use of case studies, with regard to the effects of various zone configurations on personnel safety, production, and system acceptance.
This presentation will educate the audience on how proximity detection can be an extremely effective safety technology, while striking a balance with production demands. The critical element is the understanding of human behavior and distinguishing required human-machine interactions from those that put personnel at risk. Current technology allows the deployment of sophisticated systems providing highly dynamic safety zones and automated control capabilities, but it is the human factor that ultimately constrains what is practical and effective underground.


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Leukocyte (white blood cell) with granules that are stained by the dye, eosin. Eosinophils, normally about 1-3% of the total white blood cell count, are believed to function in allergic responses and in resisting some infections.


Bifurcation analysis of a network of three catalytic combustors with periodicallyswitched feed position is carried out. The influence of the switch time, of the feedtemperature and of the heat exchange coefficient at the wall on the dynamical behavior isstudied by a numerical continuation technique based on the spatiotemporal symmetry ofthe forced system. Symmetric and asymmetric periodic regimes are detected as thebifurcation parameters are changed. The stability range of periodic ignited regimes andtheir bifurcations are analyzed. In particular, it appears that some complex regimes arethe only stable ignited regimes at ambient feed temperature in several operating conditions.
|Titolo:||Non-linear dynamics of a VOC combustion loop reactor|
MANCUSI, Erasmo [Conceptualization] (Corresponding)
|Data di pubblicazione:||2006|
|Appare nelle tipologie:||1.1 Articolo in rivista|


VAUXHALL LIGHTS WIRING DIAGRAM
Vauxhall Workshop Manuals > Corsa D > General Vehicle
Corsa D > Vauxhall Workshop Manuals > General Vehicle Information > Schematic and Routing Diagrams > Harness Repair > Step D - Damage type 5, Replacement of complete wiring harness
Fuses and relays box diagram Opel/Vauxhall Astra H
Fuses and relays box diagram Opel/Vauxhall Astra H. Identifying and legend fuse box.
Wiring diagram rear lights vauxhall vivaro - Fixya
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VAUXHALL COMBO OWNER'S MANUAL Pdf Download.
Page 2 VAUXHALL Combo Owner’s Manual.. Page 3 Data specific to your vehicle Please enter your vehicle’s data here to keep it easily accessible. This information is available under the section "Technical data" as well as on the vehicle identification plate and in the Service Booklet. Fuel Designation Engine oil Grade Viscosity..
Rear light wire colours - Insignia Drivers UK Forum
Feb 05, 2016You don't say whether your car is the pre facelift of facelift? The may have the same wiring, not sure? But I know the facelift is definitely, RH Drivers side rear light feed, Grey/Brown (positive) Black (negative) LH Passenger side rear light feed, Green/Yellow (positive) Black (negative)
Fuse box Opel/Vauxhall Corsa D - fusesdiagram
Fuse box in passenger compartment Opel/Vauxhall Corsa D. The fuse box is located behind a cover in the glove compartment. Open the glove compartment and remove the cover. To close, first put on the cover, then lock it into position.
How to wire tow bar canbus electrics on Vauxhall Opel Insignia
Jul 30, 2017A brief description of where you need to join the cables for tow bar bypass relay to work with canbus system on a Vauxhall Opel Insignia. Opel/Vauxhall Insignia P0617 how to wire up
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text:
Study outlines factors associated with untreated diabetesUntreated or undertreated diabetes can cause debilitating complications such as blindness and amputations. Among adults with diagnosed diabetes, 87 percent reported using oral medications or insulin, 10.6 percent reported treating their diabetes with diet, but not drugs, and 2.4 percent reported not using any of these treatments. Those are the results of a study by Steven C. Hill, Ph.D., of the Agency for Healthcare Research and Quality (AHRQ), and a team of researchers from AHRQ and the Government Accountability Office.
Lack of resources was strongly associated with lack of treatment. In particular, 5.5 percent of the full-year uninsured were untreated, compared with 2.2 percent of people who had insurance for at least part of the calendar year. Similarly, 7.9 percent of those lacking a usual source of care were untreated compared with 2.1 percent of those who had a usual source of care. Lack of resources is also strongly associated with use of diet only to control diabetes. Most notably, 19.7 percent of those with no usual source of care used diet only, compared with 10.1 percent of people who had a usual source of care.
The researchers suggest that multiple strategies are needed to initiate treatment for these difficult-to-reach patients. Data for the study came from AHRQ's Medical Expenditure Panel Survey Diabetes Care Supplement, a nationally representative sample of adults diagnosed with diabetes that is administered annually. Between 2000 and 2006, 10,681 adults provided treatment information in the survey.
See "Adults with diagnosed and untreated diabetes. Who are they? How can we reach them?" by Dr. Hill, G. Edward Miller, Ph.D., and Merrile Sing, Ph.D., in Journal of Health Care for the Poor and Underserved 22, pp. 1221-1238, 2011. Reprints (AHRQ Publication No. 12-R025) are available from the AHRQ Publications Clearinghouse.
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High-end retailer Waitrose is introducing non-GM European soya into its pig rations as part of an ongoing policy to reduce reliance on South American supplies.
The supermarket has worked in partnership with its dedicated pork supplier, Dalehead Foods, to start the transition, with the first shipment from the Black Sea region having landed in October.
The move marks the start of the retailer’s plans to switch to a more sustainable source of soya beans, amid concerns about the effects of deforestation associated with soya production in South America.
It is also worried that, as demand for soya grows in other parts of the world, an overdependence on South American raw materials could undermine security of supply.
“Ultimately, this is about improving sustainability, not replacing GM soya,” said a spokeswoman.
The majority of Waitrose’s other supply chains – including own-label eggs, chicken, turkey, New Zealand lamb and farmed fish – are fed diets that do not contain GM protein.
“We have also removed all soya from the diets of our conventional milk supply chain and have plans in place to do the same in our lamb and beef supply chains,” the spokeswoman added.
Despite Waitrose’s insistence that it is motivated by the desire to improve sustainability, rather than to remove GM material from its pig supply chain, organic body the Soil Association described the move as “the biggest blow against GM crops this century”.
It marked “the beginning of the end of the last large-scale use of GM crops in the UK”, it suggested.
“GM soya from Latin America is linked to rainforest destruction, so sourcing non-GM soya from the Danube region and using more UK-grown protein crops is good for the climate, good for UK farmers and good for consumers,” said policy director Peter Melchett.
Addressing a meeting of farmers producing for Waitrose this week, Waitrose managing director Rob Collins said the move towards European soya was the result of three years’ work by the agriculture team.
“It fits perfectly into our strategy to improve our supply chain security by sourcing animal feed from raw materials grown at home, or within the UK and Europe.”
In securing European soya, Waitrose has worked closely with the Danube Soya Producers Association – a group made up of soya growers, millers and end users.
Latest statistics show that, in 2016, European soya production reached 8.6m tonnes from 3.9m ha, most of it from Ukraine.

domain: agronomy


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Histone modifications such as acetylation play a fundamental role in DNA packaging and genome regulation and HAT1 protein is involved in gene transcription, DNA repair, and chromatin assembly. Single nucleotide polymorphisms (SNPs) in the human HAT1 gene may be correlated with human diseases such as cancers, inflammatory, and neuropsychiatric diseases. Hence, identification of putative functional SNPs which affect structure and/or function of protein is important for understanding the molecular mechanisms of pathogenesis of diseases and discovery of potential therapeutic agents. In this study, numerous bioinformatics tools were used to determine the most damaging nsSNPs for the function and/or structure of HAT1 protein. In silico analysis was carried out by different algorithmic programs including SIFT, PolyPhen2, PROVEAN, SNPs&GO, and PhDSNP. Our study concludes that mutation of Leucine → Arginine at position 416 (rs199575205) is major deleterious mutation which may lead to damage of HAT1 protein. Analyis of HAT1 gene variants by computational tools is a first and comprehensive in silico study. Future in vitro and in vivo studies should include this nsSNP as main target for the development of therapeutics for diseases that are associated with this missense polymorphism.
Keywords: HAT1, nsSNP, mutation, in silico, histone

domain: health


text:
Srinagar: The Jammu and Kashmir administration has put the police department’s 168 personnel on the radar for their alleged “involvement in subversive, criminal, corrupt activities” and action against them is on the cards, reports said on Monday.
The administration had earlier sacked several civil officials including senior ones for their “direct, indirect involvement in militancy activities.”
Among 168 Jammu and Kashmir Police (JKP) personnel whose links with subversives are under investigation, only seven belong to Jammu division while 161 are in Kashmir valley, the Daily Excelsior reported quoting official sources.
The report said seven police personnel, whose credentials are doubtful and being probed by the police at the highest level in the Jammu division include two each from Jammu, Rajouri, and Poonch districts and one in Kishtwar while 161 cops, who are under radar in Kashmir, belonged to all 10 districts of the Valley.
As per the report, out of 168 police officials, whose cases are under review, two are in the rank of Inspectors, 11 Sub Inspectors, and 49 Assistant Sub Inspectors. The report said the rest of the personnel are in the ranks of Head Constables, Selection Grade Constables, Constables, and Followers.
Quoting the sources further, the report said, “The track record and credentials of the police personnel will be examined minutely. Their performance and role, if any, in subversive and militant activities will be looked into.”
There is a condition that the police personnel against whom action is proposed to be taken might have completed 22 years of service or attained 48 years of age, the sources were quoted further saying.
During the past few months, the JK administration has sacked many government employees for their alleged involvement in militant-related activities.

domain: politics


Over time, free and emulsified water, micro-organisms, organic and non-organic contaminants, and sludge build up in the fuel tank. This foreign matter can clog filters, reduce engine performance, create carbon deposits, cause incomplete combustion and loss of power, and simply wear down fuel system components. Fuel polishing removes these contaminants from the bottom of the tank and adds a fuel catalyst. The fuel is then circulated through a fuel conditioner and a series of filters that will clean and restore the fuel to a clear and bright condition — saving you fuel costs and ensuring the generator engine will operate efficiently at a moment’s notice.
GenServe’s fuel testing provides ASTM standards required by NFPA 110 Chapter 8. A written report is forwarded to our clients upon completion of the testing.
With GenServe’s emergency fuel options, our customers are assured that their facility will never be without fuel during weather-related or other emergency incidents.
GenServe’s network of equipment providers allows access to rental fuel tanks to augment an adequate supply of fuel at any time.


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AWSG and AustCham Shanghai present ExpatriART
An opportunity to view beautiful hand picked Asian art with items available for purchase. The evening will support AWSG-appointed charities, with a raffle and lucky door prizes to be won.
Members Price: 250RMB Non Member Price: 300RMB
Date: Wednesday 23 March
Time: 18:30 – 20:30
Venue: Le Royal Meridien Shanghai
For more information click here
To RSVP click here