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Share to Google plus Friday, September 28, – Sorry, not sorry,” she adds in another scene. While the trailer doesn’t shed any light on Tristan’s apology or his reconciliation with Khloe, it’s still pretty intense. It also comes just one day after Tristan was reportedly spotted acting inappropriately with another woman at a club , igniting rumours that he could have cheated on Khloe AGAIN. We’re just going to have to wait and see the drama unfold. A friend hijacks Khloe’s Snapchat and posts a video of the couple kissing at a club Snapchat 3 of 26 November Khloe appears on Jimmy Kimmel Live, where she said she “really likes” staying with Tristan in Cleveland. Tristan wishes his followers a Merry Christmas using a pic of him and Khloe in matching fur jackets. Khloe does an interview for Extra, and says she hopes Tristan is “the one” Extra February
Khloé Kardashian is pregnant, expecting first child with Tristan Thompson
Could not subscribe, try again laterInvalid Email Khloe Kardashian has long been the subject of speculation about her family plans, with rumours about her pregnancy starting in September when she would have been around three months gone. And she finally confirmed the news last night with an Instagrammed snap of her baby bump, complete with sparkly ring on her left hand and boyfriend Tristan Thompson’s arms cradling her stomach. Her message announcing the pregnancy was every bit as sweet as the picture, with Khloe saying it was her “greatest dream” come true.
And the year-old dropped a big hint as to why they kept the news to themselves for so long.
This could be big news, Khloe Kardashian and Lamar Odom supporters. According to TMZ, the still-married couple went Ruth’s Chris Steakhouse on Friday night to enjoy dinner together. Reportedly.
GossipCenter Khloe Kardashian used the gym as her refuge when she was going through her marriage issues with Lamar Odom. The Keeping Up with the Kardashians star, who split from the basketball player in , has opened up about the couple’s issues – including Lamar ‘s substance abuse and infidelity, but kept it all from her famous family at the time. Khloe explains she kept their problems secret and started going to the gym to escape. It was the biggest secret I’ve kept. I just needed a place to go.
I couldn’t go to my mum’s because she would start asking too many questions. And if I went to a hotel the paparazzi would see me and it would look shady. No one talked to me. I loved that solitude. After splitting from Lamar , Khloe dated rapper French Montana and basketball player James Harden, but neither romances worked out. Despite that, Khloe insists she prefers to date celebrities because it’s easier to be discreet.
Share this article Share And the new couple are said to ‘still be in the honeymoon stages,’ with an insider close to Khloe saying that ‘they both have a huge crush on each other. He really isn’t into the ‘celeb scene’ and does his own thing. The reality star has been getting close to the Cleveland Cavaliers player since they met at a party, before jetting off to Mexico for Labor Day weekend Over it:
m Followers, Following, 3, Posts – See Instagram photos and videos from Khloé (@khloekardashian).
This tends to happen when camera crews have followed you around hours a day, six days a week, six to eight months out of the year for the past eight years of your life. The strength she displays is both honorable and threatening to anyone who tries to test her family. Over the last year or so, she had to take that strength and get stronger. On top of that, her stepfather Caitlyn Jenner formerly Bruce transitioned to become a woman.
On newsstands around L. You Slept With My Sisters! The pronouns used reflect that.
Inside Khloe Kardashian’s Quietly Momentous Pregnancy
Until next year, that is. In , the E! Khloe has confirmed that she is pregnant with her and boyfriend Tristan Thompson ‘s first child together, taking to Instagram to share a photo of her bare, till now just speculated-upon baby bump. But now that it’s beginning to look a lot like Christmas, the Kardashians have been in a more giving mood. Khloe Kardashian and Tristan Thompson’s Most Adorable Moments One day at a time for almost three weeks now, the Kards have been rolling out a scene from their big holiday card photo shoot which they skipped last year , timed to have the whole finished product on display by Christmas.
Apr 11, · Watch video · Lamar Odom is worried about his ex-wife Khloé Kardashian after videos and photos of her boyfriend Tristan Thompson cheating surfaced on Tuesday, April Khloe and Lamar’s Whirlwind RomanceAuthor: Karla Rodriguez.
Khloe was born in as the third child of Robert and Kris Kardashian. She was homeschooled after both of her sisters left high school and ended up graduating before what would have been her senior year. In , Kardashian suffered a traumatic brain injury in a car accident in which she went through the windscreen and suffered a severe concussion, causing long-term memory loss.
In September , Kardashian married basketball player Lamar Odom one month after they first met. However, after a few rocky points toward the end of their marriage, she filed for divorce in December With sisters Kourtney and Kim, Khloe is involved in the retail and fashion industries.
Khloé Kardashian is pregnant, expecting first child with Tristan Thompson
October 26, at Getty Images Who is Khloe K. To answer your question, Khloe is currently dating basketball player Tristan Thompson! But who is Tristan Thompson and what have the latest young power couple been up to? Keep reading, because we have everything you need to know about the most-talked about couple.
Feb 02, · Naturally, that bit of unpleasantness was what got Kim Kardashian to threaten to ruin Lamar Odom if he comes after Khloe again. On Wednesday morning, Rasual Butler and .
Fans rejoiced for the reality stars, particularly for Kardashian, who has endured a lot of heartache while dreaming of becoming a mom. A baby has been a long and tough time coming for her. As we bask in Kardashian’s pregnancy glow and look forward to an exciting future with her bundle of joy, let’s also take a closer look at the rocky road that brought her to this place and the challenges that have plagued her relationships and this pregnancy.
From a failed marriage to cheating rumors on the brink of delivery, Kardashian has certainly proved that she’ll be one tough and resilient mama to her daughter. Getting pregnant at the same time was totally unplanned but they are really happy about it. Kardashian revealed that she underwent fertility treatments in an effort to conceive. If that doesn’t get thicker, then I cannot carry a baby. I was 27, and I thought, ‘A baby will fix this,’ and it’s not going to fix that.
Yes, but I don’t regret it,” she said.
Khloe Kardashian dating Lamar Odom old basketball rival Rick Fox?
It comes after months of speculation regarding her pregnancy, where she refused to confirm or deny the rumours. The kids bring such joy and it makes everything worth it. Who is Khloe Kardashian’s boyfriend Tristan Thompson and how long have they been dating? He started dating Khloe back in August after she ended her fraught relationship with ex-husband Lamar Odom. The couple live together in Cleveland, Ohio.
The divorce was put on hold after Lamar was hospitalised in October after being found unconscious in a Nevada brothel, and was in a coma for four days.
Now Khloe has to make the big decision to either end their romance and stick to co-parenting little True, or forgive him and hope he doesn’t stray again. She at least has Lamar as an option, as.
Khloe Kardashian and Lamar Odom Khlomar is officially no more. Kardashian filed for divorce in December after the pair had been married for four years, but rescinded the filing after Odom was found unconscious at a Nevada brothel last year. She cited Odom’s medical condition as one reason to withdraw the divorce. She refiled for divorce , citing irreconcilable differences, in May. They have no children together. The pair started a company called Khlomar, the nickname bestowed on the couple after they started dating in
Inside Khloe Kardashian’s Quietly Momentous Pregnancy
May 26, 5: In court papers filed Thursday, Kardashian cites irreconcilable differences as the reason for the split. Kardashian filed for divorce in December and the couple signed papers in July However, months later, the divorce was put on hold.
Things have been heating up between Khloe Kardashian and new man Tristan Thompson. And the year-old and the NBA star, 25, are now ‘full-on dating,’ according to a source for Entertainment Tonight.
She told TV host Andy Cohen on Watch What Happens Live that they had made multiple sex videos while they were married, and that indeed sex tapes do exist. Khloe was asked if she still had the sex tapes and said that they did and that the tapes were in her safe. In fact, their popularity could be said to have started with a tape of her sister, Kim Kardashian having sex with singer, Ray-J.
Odom was discovered comatose at a Nevada brothel on Oct. She says she always feared the end result of his addictions and that was why she wanted a divorce. Odom, 36, is reportedly suffering from some sort of brain injury due to the complications from the brothel incident, and is undergoing rehab and is said to be having problems recognizing family members.
However, Khloe reported that for someone who was told he had only four hours to live, Odom is a walking, talking miracle and that he is fighting for his life. Top Videos of the Day She hoped the whole incident will be a wake-up call for the former athlete. The divorce has been temporarily halted while Odom recovers. She says halting the divorce has nothing to do with any sort of reconciliation between her and Odom. However, she does have some memories that she is keeping under lock and key, and that includes the reported tapes of her and Odom having sex.
She said that there is no chance the sex tape will be released to the public. Click to read more and watch the video or.
Khloe Kardashian reportedly pregnant with Tristan Thompson’s child
Her relationship timeline has not been devoid of hurdles and vicissitudes but each time, the reality television star picked herself up and moved on without wallowing in the past for too long. Read on for a complete rundown of all the men Khloe Kardashian has dated and her current prince charming. Ex-Boyfriends and Ex-Husband When it comes to relationships, Khloe has had her fair share of hard times. He still remains one of the men she dated, probably in secret since she was just 20 and working as his assistant at the time they met.
Romeo Miller — Romeo Miller and Khloe image source Better known as Lil Romeo, the rapper claimed he and Khloe were an item back in his high school days as a senior. According to him, his parents, especially his dad, Master P , frowned at the relationship and went as far as kicking her out of their house at some point.
Khloe was back in the saddle with new flame French Montana after only three months, and now Lamar has finally started dating again, too, according to a new report. Lamar Odom is back in the game.
But you can’t keep a Kardashian girl down for long. Who should be Khloe’s next man? See who we think this reality star should hook up with next. The funnyman could definitely keep up with Khloe’s outrageous sense of humor. Plus, since Khloe has experience being a stepmom to Lamar Odom’s two kids, she could definitely handle the same role for Jamie’s two daughters, Corrine and Annalise.
That is, if he’s not already dating Katie Holmes. Like Robin, Khloe is wacky, fun and loves having a good time.
After a series of short-lived relationships with James Harden and French Montana, it was really heartwarming to see her finally find happiness with a new beau. Kardashian and Thompson are constantly gushing over one another on social media and in the press, and Kardashian is often spotted courtside cheering on her man. These two aren’t engaged and have dating for less than two years, but their romance seemed to be smooth sailing as they prepared for the arrival of their baby girl.
A source told Us Weekly: He feels like it could have happened to him. This is a huge wake-up call for him. It has really shaken him. However according to TMZ , Khloe is allegedly concerned that the loss of his best friend will have a damaging effect on Lamar. Meanwhile, Khloe is said to have been warned in April that her divorce case could be thrown out if she does not move forward with it. However it seems the reality star is not quite ready to take the next step in ending her marriage.
News back in April that she still had feelings for her ex, admitting that she wished they were still together. He was my husband, and I still wish he was, and I don’t think there’s anything wrong with that,’ she said. Khloe filed for divorce from Lamar in December , but has allegedly been told the case could be thrown out if she does not move forward with it ‘There’s nothing I can do,’ Khloe continued. Khloe’s best friend Malika Haqq shared this photo with Jamie, Khloe and Lamar as she mourned the loss of her pal ‘Life doesn’t get easier but I promise you that life will make you stronger’: According to documents obtained by Radar Online, he was charged with two counts of possession of methamphetamines in April and a warrant was allegedly issued for his arrest in January when he failed to show up to court.
Jamie even appeared on Khloe and Lamar’s spin-off reality show Dead at Jamie shared this photo earlier this year.


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Defensive Back Kwantel Raines Leaving West Virginia
West Virginia sophomore safety Kwantel Raines intends to take his talent to another college.
Pittsburgh Sports Now is reporting that the former Aliquippa star has placed his name in the NCAA transfer portal with the intention of moving on to another football program.
The sophomore safety was recruited to West Virginia by former head coach Dana Holgorsen but hasn’t been able to mesh with new head coach Neal Brown and the two sides aren’t in agreement about his college position.
Raines (6’2″, 215) was recruited to West Virginia as a hybrid safety but Brown sees his future as a linebacker something Raines doesn’t agree with.
On Monday, Brown said during his press conference that “Raines is trying to figure out what he wants to do. I haven’t talked to him.”
Playing time this season for Raines has been very limited as he’s collected six tackles and one forced fumble in six games played.
The former 4-star recruit from Aliquippa is currently a redshirt freshman and would have to sit out next season and have two seasons of eligibility remaining at his next school.
The question now is where will Raines look to resume his college career? Keep in mind that his main recruiter to West Virginia was former defensive coordinator Tony Gibson, who’s now with NC State. Also, Pat Narduzzi and Rob Harley both recruited Raines very hard and the Panthers were the runner-up to West Virginia.

domain: news


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‘Angels in America – Part 1 Millennium approaches’ is an exceptional adult drama, written by Manhattan born Tony Kushner, it explores the 1980s AIDS epidemic. Kushner, who is one of America’s most admired playwrights, wrote this richly devised play when he was barely 30, just before he ‘came out’.
‘Part One’ of the play caused ructions and the ire of morality groups when it was released, yet it went on to win every major award, including a Pulitzer Prize and two Tony Awards for Best Play.
This wonderful mammoth, 3-hour drama can be seen at the Heath Ledger Theatre, State Theatre Centre, Northbridge nightly at 7.30 until Sunday 19th June.
The stage is devoid of the normal flats and scenery, instead the sides of the stage have walls of lamp rigs – spots, floods, the full range; there are about 70 lamps on each side of the stage arranged at a dozen different levels.
The whole ‘ceiling’ of the stage comprised dozens of opaque Perspex panels, lit from above. The set and costume designer, Christina Smith, has selected numerous superb props, which completely satisfy the audience, giving a full mental picture of the venue, wealth etc.
The back wall consisted of black drapes that blended into infinity. They subtly opened and closed, allowing props and cast to enter. The numerous props / furniture entered silently and smoothly on travelling floor belts. Stage manager Peter Sutherland and his assistant, Claudia Blagaich certainly had to work for their crust in this show.
The work of the company’s mechanist, Nathan Fry, is often taken for granted, but here the directors and designer have created moving furniture, fly wire harness, the incredible wrath of God, inclement weather, a descending coffin and a spectacular final scene that left the audience speechless. Superb work.
On this occasion, it was good to see the major stage teamsters being invited to join the actors for the curtain call.
This synopsis of the story is more informative than usual, and for some, may contain too many spoilers; however, for others it may help them follow the unusual storyline.
It is 1985 in New York City, and we are at the funeral of Louis’s grandmother, with the aged Rabbi Chemelwitz (Toni Scanlan) blundering his way through a vale. After the service, ‘word processor’ Louis Ironson (Will O’Mahony), a neurotic lover, meets Prior Walter (Adam Booth) his partner of four years. Prior tells Louis that he has contracted AIDS. After months of caring for Prior, unable to cope, Louis deserts his friend in his final hours of need.
Louis then embarks upon a relationship with the apparently ‘straight’ Mormon lawyer, Joe Pitt (Stuart Halusz) who, due to his latent homosexuality, has been having difficulty living with his wife, Harper. Agoraphobic ‘Buddy’ Harper (Jo Morris) is a Valium-addict, who fanaticises her way out of her misery, by planning holidays with imaginary travel agent, Mr. Lies (Kenneth Ransom).
True-life, brutal, right-wing solicitor, Roy Cohn (John Stanton) – who is gay, but despises other gays – offers Joe a senior post in the Washington Justice Department.
We next see Prior desperately sick in bed. In a dream the daunting Angel of America (Felicity McKay) with a divine presence, has descended from Heaven and nominates Prior to become a prophet and spread the message. He declines the offer, but poor Prior could not start to contemplate the suffering in store for him. Prior turns to his best friend, dependable, ex-drag queen, Belize (Kenneth Ransom) for support. Prior tells Belize how he hears an Angel’s voice saying that she is coming for him – the angel’s help turns out to be an AIDS cure, and Prior goes to a hospice under the care of compassionate nurse Emily (Felicity McKay).
In one fantasy episode, Harriet is informed by Prior that Joe is a closeted homosexual and, in a touching performance, she challenges her husband on the topic. Now exposed, Joe and Louis become closer, and one night whilst drunk, Joe phones his mother, Hannah Pitt (Toni Scanlan) to inform her he is Gay. His mother panics, and wants to move to New York to help guide Joe back onto the straight and narrow. She puts her house up for sale with real estate agent, Ella Chapter (Felicity McKay).
On visiting his GP, Dr Henry (Toni Scanlan), Roy finds he too has AIDS – but in denial calls it ‘liver cancer’. After high pressure from Cohn and his pathetic senior assistant, Martin Heller (Jo Morris), Joe decides to turn down Cohn’s job offer. Furious, Cohn calls Joe a wimp and goes on to say how he achieved his exalted position, even boasting how he executed Ethel Rosenberg (Toni Scanlan) for Treason as part of by McCarthy regime.
As he becomes stronger, Prior’s ancestors from 17 generations earlier, appear at his bedside. They are a medieval farmer (Stuart Halusz) and a refined, seventeenth-century Londoner (John Stanton), both of whom died of the plague. They are enlisted to prepare for the advent of the ‘Angel of America’.
Directed by two award winners, Kate Cherry and her assistant Joe Lui, this complex story required all of their skills to stop the tale from becoming bogged down, and to ensure it retained the audience’s attention throughout; this duo were magnificent.
The movement director, Lisa Scott Murphy, ensured that the numerous entrances and exits flowed perfectly. Dialect coach, Luzita Fereday thankfully had the cast all speaking with the same understated New York accent.
The storyline has aged a little, but the depth of emotion demanded and the exemplary delivery by this top notch, highly experienced troupe guaranteed a freshness. The cast had the challenging task of involving the audience in their tension, fear and stress for three hours, but by giving each actor a number of characters to play, including women playing males, it kept their performances alive. The script has several very funny sections that again lifted the show from the grim topic, retained the pace and allowed light relief.
Often in Gay plays, the cast feel obliged to caricature the characters, thankfully this cast were subtle, and even the overtly gay Belize had just the correct amount of limp wrist.
Assistant director Joe Lui, renowned for his chromatic use, has worked well with lighting designer Matt Scott to produce a remarkable visual experience from the vast lighting rigs.
Sound designer and composer, Ash Gibson Greig, was at his very best; with a backing ranging from subtle creepy, dirge-like strings to a bouncy Beatles’ tune. There were several unusual sound effects required, and these too were inspirational and dramatic.
The show had a couple of scenes that were daring even by today’s standard, but when the play was first staged, the audience’s reaction was one of horror and repulsion.
This thought-provoking show was not demoralising, but worked at every level of performance, direction and teching. A memorable, remarkable production that makes one hope ‘Part Two’ will be staged in the near future.

domain: entertainment


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Republican state lawmakers have released their proposed adjustments to the current two-year North Carolina budget.
Among the adjustments, a 6.5 percent average teacher pay raise. That’s slightly higher than what lawmakers had previously announced but less than what Governor Roy Cooper and Democrats have been pushing for.
The $24 billion plan also includes a 2 percent raise for most state workers, $161 million for the state’s rainy day fund and keeps previously announced initiatives to attract large companies to the state and to study little-known contaminants in rivers such as GenX.
The plan is likely to pass the General Assembly as is because legislative leaders have said they will refuse any amendments. Both chambers are expected to vote on the package this week, with debate beginning today.

domain: economics


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Northampton Apple Repair are an Apple repair centre located just outside Northampton town centre (I know, you would have never guessed their location would you!). Their services range from iPhone screen replacement through to Mac, IMac and Macbook hardware repairs. What these guys don’t know about the world of Apple is just not worth knowing!
Northampton Apple Repair commissioned Oxygen to develop their brand with a new, modern logo providing more impact and appeal to their target market.
The design brief was simple, “can our brand be just like Apple, but not actually be Apple…”. So, off to work we went.
The logo design was based around the clean graphics used on all Apple devices, but we couldn’t use a certain piece of ‘fruit’ because of copyright infringement, so we started to brainstorm key words that we all associate with Apple problems….cracked screen…scratches…buffering…BOOM! Our eureka moment, how many times do all us Apple users see that wonderful ticking circle and know our lives are momentarily going to end, this was our muse. Incorporating Apple’s 80’s syle rainbow colour scheme and a simple font the logo was created.
Northampton Apple Repair required a professional internet presence which advertised their services, as their tag line suggests they provide simple, effective support, so their website followed the same simple and effective design.
Our popular single page site design was developed for the project with navigable sections created to house services, imagery and contact information for the business.
A5 flyers were created following the same branding and style of the website and logo. These will be used for local distribution.
If you have a new project, whether it is a logo, website or you’re a new business, get in touch with us and we will offer an hour free consultation.
33 Albert Street

domain: design


The Anti-Money Laundering/Countering the Financing of Terrorism Division (“ACD”) of the Ministry of Law held the onboarding conference for the regulated dealers in the PSMD sector on 6 May, 22 May and 19 June 2019.
Conference Presentation Slides (PDF)
Registration Brochure (PDF)
Registration Leaflet (PDF)
LicenceOne Guide for Regulated Dealers (PDF)
Notice for Customers (PDF)
Guidelines for Regulated Dealers (PDF)
Guidelines for Regulated Dealers_Annexes (MSWord)


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© Borgis - Postępy Nauk Medycznych 4/2016, s. 246-252
*Aleksandra Marach, Jarosław Kierkuś, Józef Ryżko, Grzegorz Oracz
Familial adenomatous polyposis in children
Rodzinna polipowatość gruczolakowata u dzieci
Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children’s Memorial Health Institute, Warsaw
Head of Department: prof. Józef Ryżko, MD, PhD
Rodzinna polipowatość gruczolakowata (FAP) to najczęstszy dziedziczony zespół polipowatości powodowany przez mutacje antyonkogenu APC (ang. adenomatous poliposis coli gene). Mutacje te prowadzą do powstawania nieprawidłowych białek odpowiedzialnych za tworzenie setek polipów gruczalakowatych umiejscowionych w przewodzie pokarmowym, głównie w jelicie grubym, z których nieuchronnie rozwinie się rak jelita grubego. Istnieje kilka wariantów FAP, między innymi poronna postać FAP (AFAP), także powodowana przez mutację w genie APC, która charakteryzuje się mniejszą ilością polipów oraz późniejszym ich rozwojem w porównaniu z klasycznym FAP. Występuje również rodzinna polipowatość gruczolakowata powodowana przez mutację autosomalnie recesywną występującą w genie MUTYH zwana MAP (MUTYH-associated polyposis), której przebieg jest podobny do AFAP. Ryzyko rozwoju złośliwego raka jelita grubego na podłożu gruczolaków jelita grubego sięga niemal 100%, dlatego tak istotny jest uważny i ujednolicony sposób opieki nad pacjentami z FAP. Ze względu na brak polskich wytycznych dotyczących postępowania w przypadku rodzinnej polipowatości gruczolakowatej polscy klinicyści powinni rozważyć wykorzystanie wytycznych opublikowanych przez European Society for Medical Oncology w 2013 roku.
Familial adenomatous polyposis (FAP) is the most common inherited polyposis syndrome caused by inactivating mutation in the tumor suppressor gene called adenomatous polyposis coli (APC) gene. FAP is characterized by the presence of hundreds of colorectal adenomatous polyps that inevitably lead to colorectal cancer. There are multiple related conditions caused by mutation in APC gene such as attenuated FAP (AFAP) with fewer number of polyps and delayed onset of colon cancer compared to classic FAP and MUTYH-associated polyposis (MAP) which has similar clinical manifestation to AFAP. Risk of malignancy in patients with FAP reaches 100%, that is why careful and standardized clinical management of FAP is required in order to prevent patients from developing malignancies. In the absence of Polish guidelines for the management of familial adenomatous polyposis Polish doctors should consider using Clinical Practice Guidelines on Familial risk-colorectal cancer published in 2013 by European Society for Medical Oncology.
Familial adenomatous polyposis (FAP) is a rare autosomal dominant syndrome characterized by the presence of hundreds of gastrointestinal, adenomatous polyps which can develop to colon cancer at early age. FAP is caused by an inactivating mutation in the tumor suppressor gene called adenomatous polyposis coli (APC) gene. At early age symptoms may be absent, but with the development of polyps symptoms may occur. Characteristic for FAP is a large number of polyps (over 100), which usually appear in the second decade of life (1). There are multiple related conditions caused by mutation in APC gene and MUTYH-associated polyposis (MAP) which has similar clinical manifestation. Risk of malignancy in patients with FAP reaches 100%, that is why careful and standardized surveillance is required. Screening investigations include such procedures as genetic testing and colonoscopy. Once the disease is identified, surgery is the best treatment for reduction of colon cancer risk while the role of chemoprevention is limited.
FAP is the most common inherited polyposis syndrome and occurs in approximately 1:5000 to 1:17,000 (2). The disease occurs de novo with the frequency of somewhere between 1 in 8000 to 1 in 10,000 (3). Among all colorectal cancer FAP make up less than 1% (4).
To diagnose FAP more than 100 adenomas must be identified in colorectum. Typical for attenuated FAP (AFAP), the milder form of FAP, is the lower number of adenomas and later onset of the disease. Clinical manifestation of MUTYH-associated polyposis (MAP) is very similar to APC-associated AFAP.
FAP is caused by mutation in the tumor suppressor gene called adenomatous polyposis coli (APC) gene. APC is located on chromosome 5 in the q21 region and contains 21 exons (5). Mutations in the APC gene are present in 80-90% of patients with FAP (6). In the remaining patients, FAP results from the occurrence of a de novo mutation in the APC gene. The APC gene is responsible for controling β-catenin. When APC gene loss it’s function, β-catenin is active and causes cellular proliferation (7). It leads to increased probability of mutations and accumulation of changes in genetic material. If this occurs, abnormal cells may accumulate and develop into polyps and colon cancer. In case of the recessive form of adenomatous polyposis, known as MYH adenomatous polyposis (MAP) there is mutation in MUTYH gene (fig. 1) (8).
Fig. 1. Algorithm for genetic diagnosis in polyposis syndromes (9)
Signs and symptoms
The majority of pediatric patients with FAP are asymptomatic and undergo evaluation based on their family history (10). At average age of 15 years of age polyps start to develop (11), but at this time symptoms are rare. First signs of FAP occur as polyps start to grow and multiply (tab. 1). It is not safe to wait for symptoms, because it is usually connected with malignant condition. However there have been reported patients who were 5 years old when polyps were diagnosed (12).
Tab. 1. Symptoms of FAP
|Typical||When the disease is advanced|
|Blood in the stool||Continued weight loss|
|Thin stools||Continued lack of energy|
|Diarrhea and/or constipation|| |
|Abdominal pain, cramping, or bloating|| |
There are also such extra-colonic features of FAP present as (tab. 2):
– congenital hypertrophy of the retinal pigment epithelium – CHRPE. CHRPE has been reported to occur in over 50% of the carriers of the mutation in the APC gene (13). It is one of the commonest and earliest extra intestinal manifestations, it lends itself as a screening tool for family members of FAP patients. However the development of molecular biology techniques as well as incomplete penetrance has reduced its significance (14),
– polyps in upper segments of the gastrointestinal tract particularly in stomach and duodenum. Polyps can occur in form of fundus gland polyps or adenomas (15). Stomach polyps occur in approximately 50% of FAP patients and do not have a high potential to form neoplasms. 33% even to 80% of patient with FAP are diagnosed with duodenal polyps (16-18). Polyps located in the ampulla of Vater and the periampullary area can develop into malignant lesion in 4 to 12% of FAP cases (19). The risk of carcinoma is greater in ampullary compared with nonampullary adenomas and increases with the size of adenoma (20),
– dental changes.
Tab. 2. Extra-intestinal features in familial adenomatous polyposis
|Benign lesions||Malignant lesions|
|Congenital hypertrophy of the retinal pigmented epithelium||Duodenal and periampullary adenocarcinoma|
|Epidermoid cysts||Thyroid cancer|
|Supernumerary teeth|| |
|Adrenal gland adenomas|| |
Supernumerary teeth as well as osteomas and changes in tooth structure:
– desmoid tumours. In about 10% FAP patients non-cancerous tumors most often found in the abdomen are observed (21). It is also proven that desmoid tumours occur 3 times less frequently in men with FAP than in women (22),
– adrenal masses, a benign tumors in adrenal glands,
– osteomas on the skull and jaw and epidermoid cysts – Gardner syndrome.
Patients with FAP have slightly increased risk of malignancies as compared to individuals without FAP:
– duodenal and periampullary adenocarcinomas,
– thyroid cancers are observed in 1% of patients. More than 94% of cases is diagnosed in women (23, 24),
– central nervous system neoplasms (medulloblastoma) occur with low frequency of about 1% and they are usually gliomas. The occurrence of these tumors together with FAP symptoms in the intestine is described as Turcot’s syndrome (25-27),
– hepatoblastomas are rare neoplasms occurring in children. Increased risk of occurrence of these cancers in APC mutation carriers were observed but the incidence did not exceed 1% (28, 29). However it is recommended to check α-fetoprotein levels and hepatic ultrasounds from birth to 5 years of age.
Patient with FAP who are not diagnosed and treated will develop colon cancer. The average age of malignant transformation diagnosis in untreated patients is 39 years (age 34 to 43 years). Colon cancer occurs by age 20 years in 7%, and by age 25 years in 15% of patients. Extra intestinal malignancies are listed above.
Mutations in the APC gene can cause three related conditions. These conditions are now considered to be variants of familial adenomatous polyposis. These include:
– Gardner syndrome – characterized by the presence of multiple gastrointestinal polyps, osteomas and soft tissue growths (including epidermal cysts, fibromas and desmoid tumors) (30),
– Turcot syndrome – associated with the presence of gastrointestinal polyps and a central nervous system tumor (medulloblastoma) (31),
– attenuated FAP (AFAP) – characterized by fewer polyps (average of about 30 polyps) and delayed onset of colon cancer compared to classis FAP (32).
Researchers recently identified another hereditary form of adenomatous polyposis, MYH-associated polyposis (MAP). Map is caused by a mutation in the MUTYH (also called MYH) gene and is inherited in an autosomal recessive manner. Patients with this disease have fewer polyps (~30) in their colon or rectum than patients with FAP.
Characteristic for MAP is the later age of onset of adenomas and colorectal cancer. Duodenal polyposis seems to be quite frequent and sometimes severe, extraintestinal manifestations such as CHRPE, osteomas and dental anomalies are rarely observed (33).
If any APC pathogenic variant is not identified in patient with colonic polyposis, molecular genetic testing of MUTYH should be considered (34).
Some groups have reported an increased risk to develop other malignancies that are not typically associated with FAP, including ovarian cancer, bladder cancer, and possibly breast and endometrial cancer. However, the risk to develop these cancers has not been well-characterized for individuals with MAP (35, 36).
Medical management and treatment
There are no Polish guidelines for the clinical management of familial adenomatous polyposis. In 2013 European Society for Medical Oncology has published Clinical Practice Guidelines on Familial risk-colorectal cancer (37).
APC-associated familial adenomatous polyposis (FAP and AFAP)
Gene testing allows carrying out the most cost-effective screening by driving colorectal examinations to gene carriers. However, when the causative mutation is not identified, all at-risk family members should undergo colorectal screening.
In families with classic FAP, flexible sigmoidoscopy is an adequate technique because of the almost universal distribution of adenomas. This examination should be carried out every 2 years, starting at the age of 12-14 years and be continued lifelong in mutation carriers.
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1. Cruz-Correa M, Giardiello FM: Familial adenomatous polyposis. Gastrointest Endosc 2003; 58(6): 885-894.
2. Corredor J, Wambach J, Barnard J: Gastrointestinal polyps in children: advances in molecular genetics, diagnosis, and management. J Pediatr 2001; 138: 621-628.
3. Bisgaard ML, Fenger K, Bülow S et al.: Familial adenomatous polyposis (FAP): frequency, penetrance, and mutation rate. Hum Mutat 1994; 3(2): 121-125.
4. Groden J, Thliveris A, Samowitz W et al.: Identification and characterization of the familial adenomatous polyposis coli gene. Cell 1991; 66(3): 589-600.
5. Santoro IM, Groden J: Alternative splicing of the APC gene and its association with terminal differentiation. Cancer Res 1997; 57(3): 488-494.
6. Ballantyne GH: Theories of carcinogenesis and their impact on surgical treatment of colorectal cancer. A historical review. Dis Colon Rectum 1988 Jul; 31(7): 513-517.
7. Vogelstein B, Fearon ER, Hamilton SR et al.: Genetic alterations during colorectal-tumor development. N Engl J Med 1988; 319(9): 525-532.
8. Al-Tassan N, Chmiel NH, Maynard J et al.: Inherited variants of MYH associated with somatic G:C T:A mutations in colorectal tumors. Nat Genet 2002; 30(2): 227-232.
9. Balmaña J, Balaguer F, Cervantes A et al.: Familial Risk-Colorectal Cancer: ESMO Clinical Practice Guidelines. Ann Oncol 2013; 24 (suppl. 6): vi73-vi80.
10. Durno CA: Colonic polyps in children and adolescents. Can J Gastroenterol 2007; 21: 233-239.
11. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 1990; 61(5): 759-767.
12. Distante S, Nasioulas S, Somers GR et al.: Familial adenomatous polyposis in a 5-year-old child: a clinical, pathological, and molecular genetic study. J Med Genet 1996; 33(2): 157-160.
13. Caspari R, Friedl W, Boker T: Predictive diagnosis in familial adenomatous polyposis: evaluation of molecular genetic and ophthalmologic methods. Z Gastroenterol 1993; 31(11): 646-652.
14. Nusliha A, Dalpatadu U, Amarasinghe B et al.: Congenital hypertrophy of retinal pigment epithelium (CHRPE) in patients with familial adenomatous polyposis (FAP); a polyposis registry experience. BMC Res Notes 2014; 7: 734. doi: 10.1186/1756-0500-7-734.
15. Jagelman DG, DeCosse JJ, Bussey HJ: Upper gastrointestinal cancer in familial adenomatous polyposis. Lancet 1988; 1(8595): 1149-1151.
16. Domizio P, Talbot IC, Spigelman AD et al.: Upper gastrointestinal pathology in familial adenomatous polyposis: results from a prospective study of 102 patients. J Clin Pathol 1990; 43(9): 738-743.
17. Sarre RG, Frost AG, Jagelman DG et al.: Gastric and duodenal polyps in familial adenomatous polyposis: a prospective study of the nature and prevalence of upper gastrointestinal polyps. Gut 1987; 28(3): 306-314.
18. Heiskanen I, Kellokumpu I, Jarvinen H: Management of duodenal adenomas in 98 patients with familial adenomatous polyposis. Endoscopy 1999; 31(6): 412-416.
19. Cordero-Fernández C, Garzón-Benavides M, Pizarro-Moreno A et al.: Gastroduodenal involvement in patients with familial adenomatous polyposis. Prospective study of the nature and evolution of polyps: evaluation of the treatment and surveillance methods applied. European Journal of Gastroenterology and Hepatology 2009; 21: 1161-1167.
20. Basford PJ, Bhandari P: Endoscopic management of nonampullary duodenal polyps. Therapeutic Advances in Gastroenterology 2012; 5: 127-138.
21. Jones IT, Jagelman DG, Fazio VW et al.: Desmoid tumors in familial polyposis coli. Ann Surg 1986; 204(1): 94-97.
22. Klemmer S, Pascoe L, DeCosse J: Occurrence of desmoids in patients with familial adenomatous polyposis of the colon. Am J Med Genet 1987; 28(2): 385-392.
23. Camiel MR, Mulè JE, Alexander LL et al.: Thyroid carcinoma with Gardner’s syndrome. N Engl J Med 1968; 279(6): 326.
24. Bell B, Mazzaferri EL: Familial adenomatous polyposis (Gardner’s syndrome) and thyroid carcinoma. A case report and review of the literature. Dig Dis Sci 1993; 38(1): 185-190.
25. Itoh H, Ohsato K: Turcot syndrome and its characteristic colonic manifestations. Dis Colon Rectum 1985; 28(6): 399-402.
26. Itoh H, Ohsato K, Yao T et al.: Turcot’s syndrome and its mode of inheritance. Gut 1979; 20(5): 414-419.
27. Paraf F, Jothy S, Van Meir EG: Brain tumor-polyposis syndrome: two genetic diseases? J Clin Oncol 1997; 15(7): 2744-2758.
28. Giardiello FM, Petersen GM, Brensinger JD et al.: Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. Gut 1996; 39(96): 867-869.
29. Gruner BA, DeNapoli TS, Andrews W et al.: Hepatocellular carcinoma in children associated with Gardner syndrome or familial adenomatous polyposis. J Pediatr Hematol Oncol 1998; 20(3): 274-278.
30. Gomez Garcia EB, Knoers NV: Gardner’s syndrome (familial adenomatous polyposis): a cilia-related disorder. Lancet Oncol 2009 Jul; 10(7): 727-735. doi: 10.1016/S1470-2045(09)70167-6.
31. Itoh H, Hirata K, Ohsato K: Turcot’s syndrome and familial adenomatous polyposis associated with brain tumor: review of related literature. Int J Colorectal Dis 1993 Jul; 8(2): 87-94.
32. Kory JW, Randall BW: APC-Associated Polyposis Conditions. GeneReviews 1998.
33. Aretz S, Uhlhaas S, Goergens H: MUTYH-associated polyposis: 70 of 71 patients with biallelic mutations present with an attenuated or atypical phenotype. Int J Cancer 2006; 119: 807-814.
34. Sieber OM, Lipton L, Crabtree M et al.: Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N Engl J Med 2003; 348: 791-799.
35. Vogt S, Jones N, Christian D et al.: Expanded extracolonic tumor spectrum in MUTYH-associated polyposis. Gastroenterology 2009; 137: 1976-1985. e10.
36. Win AK, Cleary SP, Dowty JG et al.: Cancer risks for monoallelic MUTYH mutation carriers with a family history of colorectal cancer. Int J Cancer 2011 Nov 1; 129(9): 2256-2262. doi: 10.1002/ijc.25870.
37. Balmaña J, Balaguer F, Cervantes A, Arnold D: Familial Risk-Colorectal Cancer: ESMO Clinical Practice Guidelines. Ann Oncol 2013; 24 (suppl. 6): vi73-vi80.
38. Bulow S, Bjork J, Christensen IJ et al.: Duodenal adenomatosis in familial adenomatous polyposis. Gut 2004; 53: 381-386.
39. Dekker E, Boparai KS, Poley JW et al.: High resolution endoscopy and the additional value of chromoendoscopy in the evaluation of duodenal adenomatosis in patients with familial adenomatous polyposis. Endoscopy 2009; 41: 666-669.
40. Brosens LA, Keller JJ, Offerhaus GJ et al.: Prevention and management of duodenal polyps in familial adenomatous polyposis. Gut 2005; 54: 1034-1043.

domain: medical


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§ 24-3-3. Hearing on enlargement or relocation in towns Commissioners of estimate and assessment.
Whenever the town council of any town named in § 24-3-17, shall adjudge it to be necessary to lay out, enlarge, straighten, improve, or alter any street or highway, or any part thereof, in the town, the council may cause the same to be done in the manner following: Whenever any lands shall be required for the purpose aforesaid, and the town council shall be of the opinion that any estates will be specially benefited thereby, the council shall, after notice to all persons interested, which notice shall specify the time and place of the meetings of the council and the nature and extent of the intended improvement, and after hearing all persons who desire to be heard in the matter, appoint not less than three (3) nor more than five (5) discreet and disinterested persons as commissioners of estimate and assessment, who may be residents and taxpayers in the town; and the council may at the same time determine that a portion of the damage occasioned by taking any real estate for the aforesaid purpose, not exceeding three-fourths ( 3 / 4 ) thereof, shall be assessed upon the owners of estates which the commissioners shall find will be specially benefited by making the proposed improvement, whether any part of the estates are taken for the improvement or not; provided, that the owners shall not be assessed in any case beyond the amount that the commissioners shall consider their estates to be specially benefited thereby. The commissioners, before entering upon the duties of their office, shall be severally engaged to the faithful discharge of the trust and duties required of them.
(G.L. 1896, ch. 71, § 32; G.L. 1909, ch. 82, § 35; G.L. 1923, ch. 95, § 35; G.L. 1938, ch. 72, § 35; G.L. 1956, § 24-3-3; P.L. 1997, ch. 326, § 54.)

domain: politics


text:
This weekend, I want to drive along the Blossom Trail and stop to eat lunch. Is it a good time of the year to do so?
Fresno#downtown#city#urban#car#american#us#buldings#vsco#vscocam#instaday#instagood#us#california# (at Downtown, Fresno)
The sun doesn’t set till 7pm.
We’re always thrilled to hear about our Dot & Bo products making it to their new homes, and this EAT sign made it to a very special one. Mabel’s Kitchen in downtown Fresno, CA is an adorable cafe that serves up amazing desserts, paninis, and lunch specials. If you’re ever in Fresno, stop…
A friend from swing-dancing asked me if I wanted to participate in the 5K Graffiti Run that took place at Woodward Park last Sunday. My first reaction was to check the weather report. Yes! It was expected to be mostly cloudy. “I’m in!”, I told her.
I’m glad I finally participated in a run. It’s one of those things I keep telling myself I will do one of these days. I did absolutely no prep work for this 5K. The last time I ran a mile was over a year and a half ago and the last time before that was in high school. I can go out of town and dance for several hours at a time but running…that’s a different issue.
Fortunately, most of the participants walked. I took my sweet-ass time enjoying the route and the beautiful scenery and taking photos. The sky was, indeed, cloudy. I could faintly see snow on the mountain tops. It was a lovely day in Woodward Park.
I’ll definitely be walking this trail more often. The trail even goes to my grandma’s house! Next time, I won’t be paying the cost of a marathon.
New community mural here at The Art House. A great collaboration between students, local artists, and community members. Always by the artists for the artists. #centralvalleyart #creativecommunity #Hstreetarthouse
To-day, I drove around downtown #Fresno to take notes on properties for sale/lease for a client. I then stopped by Peeve’s Public House on the Fulton Mall to do more research on my laptop. On my right, I had a gigantic burrito from a nearby restaurant, and a Tioga Sequoia stout on my left. Now, that’s a lovely way to work!
The best part was that a young couple stopped in the pub. They’re looking to move to Fresno. I think they’re from the Bay Area. The husband wants to get into the solar industry. They’re looking for a charming house to rent in an area with a good nightlife. I told them about Downtown, Tower, and Fresno High-area.
Two other men stopped by the bar. They’re travelling orchestra musicians from Northern California. They said they were walking down the Fulton Mall and randomly saw Peeve’s. How often does that happened?! A regular was schooling them on local breweries.
Anyway, it was amazing to see new people stop by Peeve’s, especially ones from out of town. I think it’s a great first impression of Fresno and Downtown.

domain: artistic


text:
M I N E L A S E J D I N
p h o t o g r a p h e r | c r e a t i v e d i r e c t o r
I was born in Bosnia and Herzegovina, Raised in Atlanta, Georgia. I can speak four languages. I am an ENFP and a Type 4.
I love art and history. I enjoy learning new things about familiar places. I love the feeling of wholeheartedly understanding the city I am traveling to and the emotion and hurt that the city has been through.
To me, photography is a complex and multidimensional combination of art and history. A photograph is a format that evokes different interpretations and feelings from different eyes and hearts. My job is to create not just a beautiful photographic document, but also a unique expression of who you are in a way that can’t be translated by memory and words and passed down through generation. I want you to be able to wholeheartedly relive the important milestones that you treasure in your lives.
W H A T I S F I L M + H Y B R I D P H O T O G R A P H Y?


Meals per day
The new design of the center and its construction were supervised by Newrest ‘s International Technical Department with experience in numerous constructions and renovations of production units around the world.
The 1150sqm unit production includes 1 loading dock and is a 10-minutes drive from access to the ramp to facilitate logistics and be as close to our customers as possible.
The center currently supplies 800 meals a day for 10 main clients.
The Newrest Valencia production unit is ISO 9001-2008 certified and strictly respects the safety and hygiene procedures with the HACCP process.


Thank you for your observation that this story does not report innovations not already available in the market. Of course, casting automotive radar in silicon germanium instead of GaAs will reduce its cost and low-g sensors will get Freescale into the exploding electronic stability market, but these important innovations are not unique to Freescale, as you observe. Thanks again.
I think the message in this article highlights that the new smart accelerometers are designed for increased safety and growing government regulations for better electronic stability. Is there any automotive standard these products from Freescale follow?
As we unveil EE Times’ 2015 Silicon 60 list, journalist & Silicon 60 researcher Peter Clarke hosts a conversation on startups in the electronics industry. Panelists Dan Armbrust (investment firm Silicon Catalyst), Andrew Kau (venture capital firm Walden International), and Stan Boland (successful serial entrepreneur, former CEO of Neul, Icera) join in the live debate.


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A weeklong celebration of Sacramento's chefs, restaurants, and all things pork and bacon!
Bacon Fest Opening NIght at Grange Restaurant (Sunday, January 19, 926 J Street, 4 p.m., no cover) Free admission! Affordable Bacon Fest small-plates menu by chefs Oliver Ridgeway of Grange, Ravin Patel of Ella and Billy Ngo of Kru. DJ Shaun Slaughter curating tunes, special Bacon Fest cocktails and bourbon concoctions by Grange's bartenders, games and more
And we'll be raffling away prizes, including tickets to the... third annual Bacon Fest Chef's Competition and Celebration. RSVP Here
Special Bacon Fest prix-fixe dinners at: Formoli's Bistro (Monday, January 20)
Magpie Cafe (Wednesday, January 22). Call each restaurant for reservations
(and be mindful that every BF dinner sold out last year!)
Small Plates, Special Cocktails, Local Brews: Hook & Ladder (Tuesday, January 21)
Bows & Arrows with Guest Chef Kevin O'Connor (Friday, January 24). Like us on Facebook for further details.
Official Breakfasts and Brunches: Bacon & Butter (Saturday, January 25, 1119 21st Street, 8 a.m.)
The Golden Bear (January 26, 2326 K Street, 10 a.m.).
Educational Classes at the Sacramento Natural Foods Co-Op: Bacon Fest 101 w/ Chef Kevin O'Connor (Tuesday, January 21)
Bacon Fest with Aimal Formoli (Thursday, January 23). Register Here
Bacon Fest Cocktail Competition: Participating restaurants and bars (to be announced) will serve bacon-inspired cocktails all week.
A secret judge will be visiting to determine the best.
Third Annual Bacon Fest Sacramento Chefs Competition: Tickets go on sale Monday, December 30, at noon for this don't-miss celebration! SOLD OUT!
Competing chefs this year include: Patrick Mulvaney (Mulvaney's B&L), Rachel Kelley (Revolution Wines), Adam Pechal (Restaurant Thir13en), Billy Zoellin (Bacon & Butter), Michael Tuohy (Block), Brian Mizner (Hook & Ladder), Travis Surmi (Grange), Ian McBride (Lucca), Jaaymes Luu (Fat Face), Scott Ostrander (Esquire Grill), Matt Brown (Golden Bear), and Robb Vedditti (Pangaea). Prizes include expensive knives, cheap trophies--and 365 days of braggin rights.
Judges this year: chef Michael Thiemann (Mother, Empress Tavern), chef Brad Cecchi (Urban Farmer in Cleveland, formerly of Grange), chef John Gurnee (LB Steak in Menlo Park), Chris Macias (food writer, Sacramento Bee), Becky Grunewald (food editor, Edible Sacramento), and Charlie Thieriot of Rancho Llano Seco.
Each guest receives: samples of all the chefs Bacon Fest competition small bites, a plethora of Bacon Fest buffet eats by Patrick Mulvaney, two free drinks, and one vote to decide the audience award. DJ Shaun Slaughter with the tunes.
Tickets are $35 a person and proceeds go to the Center For Land Based Learning in Winters (last year, tickets sold out in a matter of days, so don't delay!) Purchase tickets here: Sorry Sold Out :(

domain: food


Sharifah and Jenn discuss lucid dreaming, The Old Guard, Shirley Jackson Award winners, series they wish they could read again for the first time, and more.
This episode is sponsored by TBR, Book Riot’s subscription service offering reading recommendations personalized to your reading life, the audiobook edition of Axiom’s End by Lindsay Ellis and Tor Books.
To get even more SF/F news and recs, sign up for our Swords and Spaceships newsletter!
The Dreamblood duology by NK Jemisin
The Binti series by Nnedi Okorafor
Abhorsen / Old Kingdom series by Garth Nix


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ACL Fest interview: Sigrid can't wait to buy groceries in Norway
Norwegian singer Sigrid gave one of our favorite sets Weekend One at Austin City Limits Music Festival. She returned Weekend Two to show off her crystal-clear vocals and powerhouse pop songwriting skills. (And Weekend Two's weather was a little more comfortable for a Scandinavian.)
Sigrid stopped by the Austin360 tent after her set and told us all about a possibly haunted family piano, the glory of Norwegian grocery shopping and how she turns a hum into an earworm. Listen to the full interview below:
Check out complete coverage of ACL Fest at austin360.com.acl.
MORE AT ACL FEST


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Abuse or addiction to drugs or alcohol affects millions of lives in the U.S. alone. It is a chronic, escalating, and relapsing condition hallmarked by drug-seeking behavior and use, despite adverse consequences that tend to accompany it. The most addictive drugs are often illicit, but not always. Some are legal for persons over a certain age to purchase, such as alcohol and products containing nicotine. Others can be obtained with a legitimate prescription and can be habit-forming, especially if taken long-term.
But what precisely makes an individual become addicted to a drug? Is it a lack of morals? Is it mental health issues or past trauma? Several factors can contribute to the development of a substance use disorder. Sometimes, it’s as much about the person’s genetics and life experiences as it is about the substance of choice itself.
That said, let’s analyze the most addictive drugs in the world—substances that hijack the brain’s pleasure and reward center to invoke false promises of happiness and satisfaction. They are listed in no particular order below.
Alcohol is both a legal and culturally-important CNS depressant that produces relaxation, relieves anxiety, and reduces social inhibitions. When alcohol is ingested, endorphin levels are elevated, and dopamine accumulates in brain regions responsible for feelings of well-being.
As tolerance increases, alcohol users require ever-increasing amounts of alcohol to achieve the same feelings of pleasure. The quest to maintain the sought-after effects of alcohol can lead to chemical dependence, and the physical and psychoemotional withdrawal symptoms of alcohol can be very dangerous.
Amphetamines are central nervous system stimulants typically available by prescription that can provide users with a burst of energy and euphoria. These substances instigate the release of “feel good” brain chemicals, especially dopamine. The effects are potent and induce pleasurable sensations in the brain’s reward center and are, therefore, responsible for the addictive properties of amphetamines.
Amphetamine withdrawal can result in “crashes.” When this occurs, the person becomes tired, depressed, anxious, or irritable and wants to continue using in a binge-like fashion to preserve the high and avoid cravings and withdrawal symptoms. Amphetamines, such as Adderall and Vyvanse, are popular among college students and seek to stay awake and active for long periods.
Benzodiazepines (e.g., Valium and Xanax), also referred to as “benzos,” are commonly prescribed to treat symptoms related to anxiety, insomnia, alcohol withdrawal, and other disorders. Although they work effectively for their indicated uses, these medications can be extremely addictive and very challenging to outcome regarding their use.
The National Institute on Drug Abuse (NIDA) reports that benzodiazepines have a relatively short half-life, which causes many users to develop a tolerance rapidly in just a few weeks. Benzo withdrawal is often an elaborate process that requires a careful tapering schedule on a long-term basis to avoid dangerous symptoms.
4. Cocaine and Crack
Cocaine is a stimulant that rapidly inundates the brain with dopamine. Because its effects are very short-lived, cocaine can be extremely addictive. Cocaine actively impairs the brain’s ability to produce its own dopamine or close down the dopamine receptors, making unwanted withdrawal symptoms possible after just one use, which can readily motivate addictive behaviors.
Crack is a rudimentary type of cocaine produced using baking soda and its powdered form. Crack is typically smoked using a crystal-like rock, prompting a faster and more intense high than powder cocaine, which is commonly snorted.
The high from crack is remarkably brief, typically lasting only about 15 minutes, and can cause severe cravings. Crack withdrawals can result in depression, agitation, and insomnia, thereby motivating repeated drug use to relieve the symptoms.
5. Crystal Meth
Crystal meth, similar to cocaine, floods the brain with dopamine and mimics norepinephrine (adrenaline). This rapidly leads to neurons being altered and requiring more to function correctly.
Crystal meth withdrawal can be grueling and last for several days, with the sufferer on the verge of mental and physical breakdown. Addicts often experience memory loss, psychosis, hallucinations, and extreme depression, all of which can drastically increase the risk of suicide as a tragic means of escape.
GHB (gamma hydroxybutyrate) is a potent CNS depressant. There is minimal legitimate medical use for GHB, although it does initially induce feelings of relaxation and euphoria. However, high doses of GHB can induce sleep, coma, or death.
Repeated use can result in GHB addiction and, ultimately, withdrawal symptoms such as anxiety, insomnia, tremors, and sweating. GHB is also notorious for its use as a party or date rape drug used to incapacitate potential victims.
Heroin is well-known for being one of the world’s most addictive drugs. Copious amounts of research indicate that a single dose of heroin may be so intense that it may be challenging to avoid repeated use and addiction. Indeed, it is estimated that at least one-quarter of individuals who try heroin will become addicted.
Heroin induces feelings of extreme euphoria and numbs the brain and body. The heroin-induced oversaturation of nerve cells with dopamine causes them to become dysfunctional and exhausted. Because a heroin abuser can no longer feel normal without the drug, the chemical’s absence drives repeated abuse.
The addictiveness of heroin can also vary depending on its method of administration. For example, studies suggest that those who inject heroin intravenously have much higher physical dependence rates than those who smoke it.
MDMA, also commonly referred to as ecstasy or Molly, is a human-made hallucinogen that affects three neurochemical systems in the brain—serotonin, dopamine, and adrenaline. While MDMA dependency has not been the subject of many studies, the available research has shown that the drug may indeed be addictive by nature.
Testing on lab rats has revealed that MDMA damages neurons that contain serotonin, and the damage can be long-lasting. People who regularly use MDMA experience rapidly increasing tolerance and withdrawal symptoms upon discontinuation, including fatigue, depression, loss of appetite, and impaired concentration.
Studies have shown that tobacco use is the #1 preventable cause of disease, disability, and death in the U.S. Unbelievably, an estimated 16 million are suffering from a significant illness caused by smoking. Nicotine, the active and addictive element of cigarette smoke, profoundly impacts the brain. Activation of receptors by nicotine can have adverse consequences for brain activity and contribute to its addictive potential.
Nicotinic acetylcholine receptors, or nAChR, also known as ionotropic acetylcholine receptors, are exceptionally responsive to nicotine. For many long-term smokers, significant brain changes caused by repeated nicotine exposure lead to an addiction.
Oxycodone (e.g., OxyContin) or is a powerful synthetic opioid. Similar in some effects to heroin, OxyContin produces a euphoric high that is caused by activation of the brain’s reward center. Oxycodone use, like many other intoxicating substances, increases dopamine levels.
People who abuse OxyContin have sometimes learned that tampering with tablets allow them to snort, inject, smoke the drug, inducing an intense high not unlike heroin. Furthermore, crushing the drug for IV administration eliminates the tablets’ time-release properties, significantly increasing addiction risk.
In fact, recent studies have found that oxycodone may act as a gateway drug for heroin, which addicts may prefer as a less-expensive alternative to the prescription medication when they can no longer afford or otherwise obtain their drug of choice.
Treatment for Drug Addiction
Regardless of which substance an individual abuses, treatment is available, and recovery is very possible. Following detox, a process that helps the patient rid their body of drugs or alcohol, persons are urged to enroll in long-term rehab treatment in residential or partial hospitalization format.
Comprehensive, evidence-based treatment, such as that provided by Just Believe Recovery Center, has been shown to increase positive outcomes. All of our programs are customized to the individual and include clinically proven services, such as behavioral therapy, counseling, group support, aftercare planning services, and more.

domain: psychology


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Pet Boarding for Dogs and Cats and Dog Daycare in Belton
The next time you travel and are unable to bring your four-legged friend along, they can stay with us! At Belton Small Animal Clinic, we are happy to offer pet boarding for dogs and cats and daycare services for cats and dogs who are current on their vaccinations.
Looking for someone to watch your pet while you are out of town? Book your cat or dog's boarding stay by calling (254) 939-5823!
Our Dog and Cat Boarding Facility
When your pet stays with us, we make every effort to ensure their comfort, health, and safety. One of our veterinarians is always available during our business hours to take care of any pets with medical issues during their stay with us. If your pet requires medication, please provide their medication as well as instructions for administration.
As our guests, pets are provided with nutritious meals and plenty of attention from our devoted staff. Dogs are walked two to three times daily and cats are given ample opportunity to exercise.
Cats and dogs board in separate areas and each is kept in individual, spacious kennels. If you would like your two pets to share a space instead of being kept individually, we will work to accommodate this request. However, animals can only board together if they are small and of the same species.
Have a special request? Ask us! We try to accommodate as many requests as we can when it comes to your pet’s care.
Dog Daycare Services
Is your new puppy not ready to be left alone, yet? Does your work schedule prevent your pet from exercising or socializing enough? No matter the reason your pet needs to get out of the house, we can help. In addition to our overnight pet boarding services, Belton Small Animal Clinic is proud to offer regular dog daycare service for pets who may need extra attention or care.
As with boarding, participating pets must be current on their vaccinations. Our caring staff can provide pets with any requested medication or meals during their day with us and all animals are guaranteed plenty of exercise time.
Schedule a Boarding or Daycare Visit
We understand that it’s difficult to leave your pet in an unfamiliar environment. Therefore, we encourage questions about our pet boarding for dogs and cats and dog daycare facilities. We want you and your pet to be as comfortable and relaxed as possible during your separation. Call us today at (254) 939-5823 to set up a personal tour of our facility or to schedule your pet’s stay.

domain: pet


text: In the fall of 1996, The San Jose Mercury News reported on a drug trial in Los Angeles where informants testified that they had sold drugs to LA street gangs in order to finance the CIA-backed Contra war in Nicaragua in the 1980s. They testified that the drugs came from the Mena Arkansas operations. The story grabbed the headlines and incited the black community. It was soon realized that what was seen in Los Angeles was just another tentacle of what had already been uncovered in Mena, Arkansas. Now the CIA, the Justice Department, Congress and the White House were all asked for explanations. Mushrooming beyond control, the Mena scandal had finally reached the headlines of the mainstream media a decade after the events took place. By December, 1996 CIA Director John M. Deutch resigns. Also there are reports of the U.S. Government involved with a Bolivian cocaine lab. There are a string of murders of Americans surrounding the lab in Bolivia.

domain: history


text:
Danzinger Vineyard & Winery
Perched atop the Alma Bluffs, in Buffalo County, Wisconsin, overlooking the Mighty Mississippi River, Danzinger Vineyards invites you to come take in the view while enjoying a glass of our finest wines on our outdoor patio. We offer free wine tasting daily. Tours by appointment only. Our vineyard including 15 acres started in 2003. With 6 years of growing grapes it was time to build the winery.
Hours of Operation
March 15-December 31: Daily 10am-5pm. Closed: January 1-March 14.
From Alma, Wisconsin on Wisconsin State Highway 35, Take County Road E to the Top of the Alma Bluffs.
- Disabled Access

domain: geography


Includes the hire of the studio, the Fazioli 212 piano and sound-engineering equipment, and the sound engineer’s work. The price of a studio hour is the same for recording, editing, mixing and mastering.
The price includes the hire of the studio, the Fazioli 212 piano and sound-engineering equipment, and the sound engineer’s work.
For musical schools students
* We only expect you to purchase 120 copies of the CD with music you will record at PianoRoom. Learn more.
|Services||Regular price||Price for students|
|Studio hour||45 EUR||35 EUR|
|10 studio hours||400 EUR||320 EUR|
|20 studio hours||700 EUR||560 EUR|
Prices of studio hours and packages are covering the entire work related to recording, editing, mixing or mastering. It also includes the work of sound engineer.
Preparation of studio and piano for recording in not charged. Recording time is the net time spent for recording, mixing, or editing.
Minimal lease: 2 hours.
After a full hour, the price is raised after the first 30 minutes of the next hour.
We recomend piano tuning specifically for the recording. Price is 110 EUR.
Book via email firstname.lastname@example.org. We are also available on phone +386 41 621 191.
Tax is included in the price.
Please note that master recording is handed after your payment, until then, it represents the property of the studio .
We reserve the right to change the term of the recording in case of extreme weather conditions.


text:
A lost dog that was found wandering Ketcham Road in Howell is still waiting to be returned to his rightful owner after two weeks with a township family.
The small unneutered male Puggle, described as tan with a black face, a bent left ear and a right ear that stands straight up was found on Ketcham Road on August 2 between Casino and Elton Adelphia Road. The pup was found not far from Our House restaurant.
It was found with a red leash around its neck but no tags. If you have any information please contact Amy Fankhauser at 732-751-0815.The original announcement was posted on the Paws Alert page of the Howell Township website where information about lost and missing dogs can be found.


U.S. President Donald Trump’s move to blacklist major Chinese companies is unnerving large conglomerates. Tech stocks, including Alibaba and Xiaomi, are seeing renewed demand in Hong Kong from investors fearing U.S. restrictions.
Ironically, the migration of Chinese companies from the U.S. stock market fuels the demand for Hong Kong stocks.
After TikTok and WeChat, the U.S. government said it might restrict China’s biggest chipmaker SMIC.
On September 8, President Trump vowed to scale back from U.S.-China ties . He said he would impose tariffs on American firms that leave the U.S.
Until the November Presidential election, strategists anticipate President Trump to heighten the pressure on China.
Amid the uncertainty around the ‘Phase 1’ trade deal, the Trump administration is continuously targeting individual companies.
But President Trump’s strategy might be benefiting China over the long term.
Sam Le Cornu, the CEO of Stonehorn Global Partners, said it is causing more capital inflow into Hong Kong stocks.
He said a “huge amount of money” is arriving back to Hong Kong and its initial public offering (IPO) market.
Throughout the year’s end, Cornu expects an increase in IPOs in Hong Kong. The trend could catalyze more well-established Chinese stocks to move away from the U.S.
The concerning trend results in two scenarios. First, it could cause China’s stock market to expand. Second, it boosts Hong Kong after the U.S. revoked its special relationship with the region.
In July, President Trump said at the White House that the U.S. would treat Hong Kong as China. He said:
“Hong Kong will now be treated the same as mainland China.”
Merely two months after the decision, multi-billion dollar tech companies are flowing into Hong Kong.
The departure of Chinese companies from the U.S. might not necessarily harm the U.S. But it could benefit Hong Kong and the sentiment around local stocks.
In the near term, Cornu anticipates more companies to follow the trails of Alibaba and JD.com. He said:
“There’s money to be made when looking at this activity. I think the second half of the year will see an increase… in these IPOs.”
The Shenzhen Stock Exchange, which tailors to tech companies, has also observed increased listings in recent weeks.
The Hang Seng index has aggressively started to include key tech stocks into the index in a short period.
On September 7, the index listed Alibaba and Xiaomi, two Chinese tech giants. Since mid-August, many investors began to swap Alibaba’s U.S. stocks for Hong Kong’s.
CreditEase Wealth Management executive Nelson Yan said long-term fund managers are increasingly considering moving to Hong Kong-listed shares.
Merely three months ago, wealthy investors in Hong Kong were preparing for the worst-case scenario. Watch the video below:
Jeffries’ report expressed newfound optimism towards Hong Kong stocks , expecting the Hang Seng index to expand. The report reads:
“In our view, it is not unthinkable that the index will be expanded as more companies come to the market… We remain bullish on the HSI.
The U.S. finds itself in an uncomfortable position wherein it maintains its tough stance in Hong Kong but its policies are catalyzing the local stock market.


text:
We provide a variety of cancer services.
You can find out about these services by contacting your local health service. Alternatively, please contact the Director of Cancer Services and Innovation, or find details of our cancer services listed below.
For more information about cancer services, please visit CanRefer.
Central West Cancer Centre (CWCc) in Orange offers a comprehensive range of locally based services including:
- A radiotherapy treatment centre with two linear accelerators, and two Radiation Oncologists, and medical physicist and radiation therapist staffing;
- Purpose built Oncology Unit with nine chemotherapy treatment chairs and one bed;
- Two Medical Oncologists; and
- A Haematologist and visiting Haematologist from Royal Prince Alfred Hospital (RPAH) in Sydney.
In Bathurst, cancer services are provided at Daffodil Cottage, a purpose-built facility with 10 chemotherapy treatment chairs. The service is coordinated by locally based Oncology Nurses, and supported by regular clinics by visiting Medical Oncologists, Radiation Oncologists, and a Haematologist from Orange.
Cancer services in Dubbo are provided at the Alan Coates Cancer Centre, a purpose-built facility within the grounds of Dubbo Hospital with eight treatment chairs. A locally based Medical Oncologist and Haematologist lead the service with Oncology Nurses coordinating care for people with cancer.
Additional visiting specialists provide outpatient clinics in Dubbo:
- Medical Oncologists from the Chris O’Brien Lifehouse, Camperdown;
- Radiation Oncologists from Orange;
- Haematologists from Royal Prince Alfred Hospital (RPAH) in Sydney;
- The Medical Oncologist at Dubbo also provides outpatient consultation clinics at Mudgee, Cobar and Walgett.
Nursing and allied health services
The Oncology services in Bathurst, Orange and Dubbo are coordinated by Oncology Nurses under the supervision of Nursing Unit Managers, and deliver chemotherapy and other supportive treatments.
Psycho-Oncology Counsellors are based in Orange and Dubbo, and provide support and counselling for people with cancer, their partners, carers and families.
Cancer Care Coordinators located in Bathurst, Orange and Dubbo, and McGrath Breast Care Nurses in Bathurst, Mudgee, Orange, Parkes and Dubbo assist patients and carers to navigate the often complex pathway from the diagnosis of cancer to specialist appointments and ultimately treatment, and offer emotional support as part of their role.
Outreach chemotherapy treatment clinics are held in Mudgee, Parkes and Cowra, where Oncology Nurses administer chemotherapy and supportive treatments weekly. Current services include:
- The Mudgee Outreach Chemotherapy Treatment Clinic has four chairs and provides a weekly clinic coordinated and clinically supported by the oncology nurses based in Dubbo, together with a Mudgee-based oncology nurse.
- The Parkes Outreach Chemotherapy Treatment Clinic has four chairs and offers a twice weekly clinic which is clinically supported by Oncology Nurses based in Orange, together with Parkes-based Oncology Nurses.
- Within the Cowra service, chemotherapy is provided in a ward area with three chairs, refurbished in 2014. The service is coordinated by Oncology Nurses and offered four days per week.
An Oncology Clinical Nurse Consultant provides clinical support and leadership across the Local Health District, and services are also supported by Oncology Clinical Nurse Educators in Bathurst, Orange and Dubbo. Community nursing and allied health staff support patients through the treatment phase and provide support for enhancing health literacy in their communities.
Haematology encompasses a wide field of practice, from the most aggressive forms of malignancy, such as acute leukaemia, to the supportive care of all patients with transfusion and coagulation management.
It is vital for the provision of cancer treatments, as well as many other important medical services such as pathology and clinical trials . The last few years has seen a growth in the local availability of this specialist service with the appointment of haematologists at both Orange and Dubbo.
Visiting haematologists from Royal Prince Alfred Hospital also provide support for the more complex services within the Local Health District. Services are provided at Dubbo, Orange and Bathurst Health Services, as well as outreach services in Mudgee and Cowra.


What are the Main Points of Maintaining the Rebar Straightening and Cutting Machine?
As a unique construction engineering equipment, rebar straightening and cutting machine manual must be carefully interpreted before application and the key points of operating mechanical equipment must be mastered: do not blindly access to the power supply, in the premise of no target, indiscreet start and debug will cause damage to cutting machine. When the equipment leaves the factory, manufacturers generally promise to help customers install and debug the equipment. However, as consumers, it is still very necessary to read the operation manual carefully.
The key points of using rebar straightening and cutting machine are as follows:
First, before using the rebar straightening and cutting machine, check whether all the cutting tools are installed properly, whether there are foreign matters in each traditional system and the parts that need to be moved. If so, remove them in time to avoid damaging the cutting tools when testing the machine;
Second, check the gap between the cutting tools. According to the instructions, the gap should be between 0.5 and 1 mm. If the gap is too big, there will be a burr on the surface of the processed steel bar;
Third, when using the rebar processing equipment to cut the rebar, the operator should hold the rebar firmly with his left hand, to avoid the broken rebar fragments from jumping out and getting hurt.
After the daily work is completed, it is necessary to clean the cutting tool promptly, and at the same time, clean up all kinds of sundries around the cutting tool to keep the whole cutting machine clean and tidy.
November 3, 2018Rebar cutting machine is a kind of tool used for shearing rebar. Generally, there are automatic steel cutting machines and semi-automatic steel cutting machines. It is a steel processing equipment and...view
May 9, 2022Ⅰ. Motor control method of reinforcement bending machineThe reinforcement bending machine motor drives the eccentric disc to rotate through a double belt pulley and two sets of spur gears. The eccent...view
January 11, 2022The steel bar straightening machine is used to straighten the steel bars. Take a model with eight orthodontic wheels as an example. The four wheels in the middle are responsible for straightening, and...view
October 4, 2020Several parts like welding specifications, equipment construction and major configuration and other aspects should be considered.Welding specification: wire diameter is generally 5-12 mm, 3-6mm, 2-4mm...view
March 24, 2020Steel wire straightening machine is a straightening equipment for metal profiles, bars, pipes, wires, etc. The steel wire straightening machine changes the straightness by extruding the bar with strai...view
February 25, 2020I.shear installation and test run of rebar shear1.Rebar shear machine shall be installed on flat and solid ground.2. When installing the bearing frame, the center of the bearing frame material groove ...view


text:
|Type||5 mins||15 mins||Hourly||Daily||Monthly|
|Technical Indicators||Strong Buy||Strong Buy||Strong Buy||Strong Buy||Strong Buy|
|Summary||Strong Buy||Strong Buy||Strong Buy||Strong Buy||Strong Buy|
Filter Table By:
|Pattern||Timeframe||Reliability||Candles Ago||Candle Time|
|Belt Hold Bullish||30||Current|
|Tri-Star Bearish||15||1||Nov 01, 2019 03:15PM|
|Abandoned Baby Bearish||1M||5||May 19|
|Tri-Star Bearish||30||6||Sep 04, 2019 12:30PM|
Target Corporation (Target) is a general merchandise retailer selling products through its stores and digital channels. Its general merchandise stores offer an edited food assortment, including perishables, dry grocery, dairy and frozen items. Its digital channels include a range of general merchandise, including a range of items found in its stores, along with an assortment, such as additional sizes and colors sold only online. Its owned brands include Archer Farms, Market Pantry, Sutton & Dodge, Art Class, Merona, Threshold, Ava & Viv, Pillowfort, Room Essentials, Wine Cube, Cat & Jack, Simply Balanced and Wondershop. Its exclusive brands include C9 by Champion, Hand Made Modern, Mossimo, DENIZEN from Levi's, Nate Berkus for Target, Fieldcrest, Kid Made Modern, Genuine Kids from OshKosh and Liz Lange for Target. As of January 28, 2017, the Company had 1,802 stores across the United States, including 1,535 owned stores, 107 leased stores and 160 owned buildings on leased land.Read More
|Securities Investor Protection Corporation (United States)||$0||Start Trading|
|National Futures Association (United States), Financial Industry Regulatory Authority (United States), Securities Investor Protection Corporation (United States)||$500||Start Trading|
|U.S. Commodity Futures Trading Commission (United States), Securities and Exchange Commission (United States)||$0||Start Trading|
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text:
The Last Ride Together
by Robert Browning
The Last Ride Together
by Robert Browning
I SAID—Then, dearest, since ’tis so,
Since now at length my fate I know,
Since nothing all my love avails,
Since all, my life seem’d meant for, fails,
Since this was written and needs must be—
My whole heart rises up to bless
Your name in pride and thankfulness!
Take back the hope you gave,—I claim
Only a memory of the same,
—And this beside, if you will not blame;
Your leave for one more last ride with me.
My mistress bent that brow of hers,
Those deep dark eyes where pride demurs
When pity would be softening through,
Fix’d me a breathing-while or two
With life or death in the balance: right!
The blood replenish’d me again;
My last thought was at least not vain:
I and my mistress, side by side
Shall be together, breathe and ride,
So, one day more am I deified.
Who knows but the world may end to-night?
Hush! if you saw some western cloud
All billowy-bosom’d, over-bow’d
By many benedictions—sun’s
And moon’s and evening-star’s at once—
And so, you, looking and loving best,
Conscious grew, your passion drew
Cloud, sunset, moonrise, star-shine too,
Down on you, near and yet more near,
Till flesh must fade for heaven was here!—
Thus leant she and linger’d—joy and fear!
Thus lay she a moment on my breast.
Then we began to ride. My soul
Smooth’d itself out, a long-cramp’d scroll
Freshening and fluttering in the wind.
Past hopes already lay behind.
What need to strive with a life awry?
Had I said that, had I done this,
So might I gain, so might I miss.
Might she have loved me? just as well
She might have hated, who can tell!
Where had I been now if the worst befell?
And here we are riding, she and I.
Fail I alone, in words and deeds?
Why, all men strive and who succeeds?
We rode; it seem’d my spirit flew,
Saw other regions, cities new,
As the world rush’d by on either side.
I thought,—All labour, yet no less
Bear up beneath their unsuccess.
Look at the end of work, contrast
The petty done, the undone vast,
This present of theirs with the hopeful past!
I hoped she would love me; here we ride.
What hand and brain went ever pair’d?
What heart alike conceived and dared?
What act proved all its thought had been?
What will but felt the fleshly screen?
We ride and I see her bosom heave.
There ‘s many a crown for who can reach.
Ten lines, a statesman’s life in each!
The flag stuck on a heap of bones,
A soldier’s doing! what atones?
They scratch his name on the Abbey-stones.
My riding is better, by their leave.
What does it all mean, poet? Well,
Your brains beat into rhythm, you tell
What we felt only; you express’d
You hold things beautiful the best,
And pace them in rhyme so, side by side.
‘Tis something, nay ’tis much: but then,
Have you yourself what ‘s best for men?
Are you—poor, sick, old ere your time—
Nearer one whit your own sublime
Than we who never have turn’d a rhyme?
Sing, riding ‘s a joy! For me, I ride.
And you, great sculptor—so, you gave
A score of years to Art, her slave,
And that ‘s your Venus, whence we turn
To yonder girl that fords the burn!
You acquiesce, and shall I repine?
What, man of music, you grown gray
With notes and nothing else to say,
Is this your sole praise from a friend,
‘Greatly his opera’s strains intend,
But in music we know how fashions end!’
I gave my youth: but we ride, in fine.
Who knows what ‘s fit for us? Had fate
Proposed bliss here should sublimate
My being—had I sign’d the bond—
Still one must lead some life beyond,
Have a bliss to die with, dim-descried.
This foot once planted on the goal,
This glory-garland round my soul,
Could I descry such? Try and test!
I sink back shuddering from the quest.
Earth being so good, would heaven seem best?
Now, heaven and she are beyond this ride.
And yet—she has not spoke so long!
What if heaven be that, fair and strong
At life’s best, with our eyes upturn’d
Whither life’s flower is first discern’d,
We, fix’d so, ever should so abide?
What if we still ride on, we two
With life for ever old yet new,
Changed not in kind but in degree,
The instant made eternity,—
And heaven just prove that I and she
Ride, ride together, for ever ride?
The Dramatic Monologue – A Powerful Tool in the Art of Poetry
The Last Ride Together by Robert Browning is about two lovers, David and Lisa who were planning to get married. However, Lisa’s grandmother has died and David has lost his memories. He longs to have those memories again so he decides to propose to her. However, there is no time to get to know each other before their wedding so they make a decision to get a Motel Two for their honeymoon trip. The Last Ride Together tells the story of this couple’s misfortunes and how they’re finally able to find happiness despite everything they had been through.
The Last Ride Together starts off with a beautiful description of the author’s home. It’s a house with no soul in it. The former lover can only fill the empty void in him with every passing minute. His grandmother only wants him to be happy. She is his medicine and he longs to return to his old days where he used to feel bliss. His grandmother teaches him that true joy comes from within and not without.
It was like heaven as he and his lover were locked in the bedroom. He could hardly move because of his exhaustion. He wanted to go back to the days where he was happy but instead, he looked at his misery and felt even more enamored of his new bride. He wanted to spend every moment of his lifetime with her because they had a promise that after their wedding, there will still be a chance to enjoy his bliss.
But then fate intervenes. It’s the kind of thing that you can’t really count on but you can’t ignore it either. A few days before their final ride, David learns that his lover has been having an affair. The news shocks him because he always thought that his beloved only loves him when he’s around and he’s heartbroken to find out that she’s already strayed.
The Last Ride Together by Robert Browning is a beautifully written collection of poems about love, life, and the transient nature of human emotions. It is a collection of poems that Browning has composed mostly while sitting in a railway station waiting for the next train to take him home. The poems are sad but at the same time filled with happiness and joy and by the end of the poems, you are almost ready to burst into song because you just cannot take your eyes off the woman sitting by the window.
The title of the poem, The Last Ride Together, refers not only to the happy ending but also to the sadness of the whole situation. As the poet states in one of his poems, a long ago friend once asked him, “How do you feel when your lover or you or somebody you love dies”. Robert Browning answered that he felt like dying right then and there because he realized how short life could be. The Last Ride Together tries to remind us of this fact by reciting a number of beautiful lines that contain a powerful impact on the minds of all readers.
The poem starts with the lines “I had a beautiful lady once; / That was my friend, and I know that she was loved.” The beautiful woman whom Browning had loved and cherished very much was his friend. He knows that she was loved because she gave him joy every day, whether it was riding in the train or just sitting beside him in the army. The poet also reminds us that even if we are too busy living our own lives, there is still something inside us that will give us pleasure. The Last Ride Together recites many such examples throughout the poem and then finishes it with a final plea: “So, take me to your garden to see the flowers that I love.”
The Last Ride Together as a whole conveys the message that poetry can only be art if the poet has created it with great love and passion. This is why many people feel that the best form of art is the dramatic monologue. This is why many of today’s greatest poets include a brief monologue at the end of their poetic works. The Last Ride Together thus reminds us how important it is to let our emotions show through our poems – even if it just means reciting a beautiful poem.

domain: literature


text:
Monday, June 27, 2005
Sneak preview of the President's speech
"Some others are eager to enlarge the conflict," Johnson warned his audiences. "They call upon the U.S. to supply American boys to do the job that Asian boys should do." But the President was full of reassurances: "We are not about to send American boys nine or ten thousand miles away from home to do what Asian boys ought to be doing for themselves," Johnson explained to his audiences. "We don't want to get . . . tied down to a land war in Asia."


text:
Walk with Washington
Washington Elementary School Principal Brian Zamarripa is inviting any past Washington teachers, principals and students to walk with the school during the 79th annual Blossom Parade, set for May 6. The school is meeting at the Cañon City Library at 11:45 a.m. on the day of the parade, which has the theme of "Back to Our Roots."
If the children in Washington Elementary School's running club tried to travel 100 miles away from Cañon City, they could end up in Denver.
But for the past school year, members of the 100 Mile Club have been running around Cañon City, in places ranging from Skyline Drive to the playground at Washington.
"I just think it's a great opportunity for kids to connect with their families and community," said Annette Nimmo, Washington's wellness coordinator.
Nimmo, who helps lead the club with wellness co-leader Stacy Murphy, said the club is open to Washington students, staff and parents and has been up and running for the past four years. This year, she added, many students already have exceeded their goal of running 100 miles. The effort is part of the school's involvement in the Billion Mile Race, an New Balance Foundation project that encourages schools nationwide to get active. So far, Washington has logged 2,518 miles as part of that effort.
But as the club has grown, the biggest visible change has been in relationships, Nimmo said.
"The biggest thing that I see are the relationships that kids build, and year to year, the friendships that keep going," she said.
The club falls under the umbrella of the wellness team at Washington Elementary, where Nimmo and Murphy encourage the school to participate in healthy activities. Most recently, the team hosted a 5-kilometer color run for the entire community. Proceeds from the run, which attracted about 65 participants, are going to fund fitness trackers for the school's gym classes, Nimmo said.
Overall, she said, "we promote health and wellness in our school with activity, and we have our healthy cooking class and then we promote challenges."
As the wellness team continues its efforts, Nimmo said it will plans to continue healthy cooking classes and fitness activities. Additionally, the running club has expanded to Lincoln School of Science and Technology, Cañon Exploratory School and McKinley for next year.


text:
Newark, NY Family and Kids
Learn about Family and Kids businesses in Newark, NY. Get the latest local news and offers for Family and Kids near you.
Most Recent from Newark, NY Family and Kids Businesses
According to the latest industry reports, more than 1.4 million Americans benefited from hospice care in 2016. Under the care of trained professionals, hospice offers comprehensive medical support and personal guidance to those with term...read more
Making end-of-life decisions for a loved one can lead to difficult, emotional conversations. However, hospice care is often the best arrangement for those experiencing chronic illness. If your loved one’s doctor says the treatment is no ...read more
Newark, NY Family and Kids Businesses
140 Bay Street
Jersey City, NJ 07302
Are you looking to enhance your child’s learning experience and provide them with the best early childhood education available? FasTracKids – Jersey City are the leading innovators in international early childhood education for ages ...
800 West Miller Street, Suite #6
Newark, NY 14513
Health problems and physical hurdles that come with aging, illness, or disability can make day-to-day life difficult. Specialized care can help these individuals maintain their quality of life while keeping a sense of independence. Found...
More Announcements & Events
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text:
enamel steel mug united by blue tent dreams oz.
tv wall mount 24 inch studs full size of mounting on drywall without installing hanging the easy for t.
oil rubbed bronze barn door handle pulls iron pull hardware bypass amazon.
3m command strips heavy duty home improvement contractors baltimore md.
white acrylic table perspex dining art products leveling.
christmas tree ladder decoration decorated as.
100 lb propane tank pound for sale.
gray bathroom floor ideas example of a transitional black and white tile cement multicolored walk.
shelter kit homes assembly required.
pictures of succulents poisonous to dogs troubleshooting what is wrong with my succulent.


- Jul 2, 2011
- Gigabyte Z490 Vision D
- RX 5700XT
- Classic Mac
- Mobile Phone
Please try the process of elimination:
If nothing seems to help, it will be necessary to contact Gigabyte Tech Support.
- Start by disconnecting all Thunderbolt devices (they can be hot plugged later)
- If problem persists:
- Boot with only 1 monitor connected. Check again.
- Remove any PCIe cards other than GPU and WiFi/BT. Check again.
- Disconnect external USB devices except keyboard and mouse. Check again.
Ok, thanks, I will investigate.
I only have a single external Drive as my Time Machine Backup
Also, I have a Corsair Commander Pro and Lighting Node Core connected but all this was working ok when I first completed my build (and applied UPS detection fix).
Seems to have started happening since adding an SSD for testing Big Sur but that has been removed.


text:
Fubar is a bar/club dedicated to quality House Music and good vibes. As one of Haad Rin's original underground party places it's visited regularly by the local 'farang' of the island. With comfy couches, yummy cocktails and friendly faces it doesn't take long to become a part of the Fubar Family.
On Full Moon nights Fubar has an intimate vibe and is always pumping great house music until the sun comes up warming everyone up for Backyard Bar after party!
They are best known for their Monday Session parties and the love of house music shines through with numerous international DJ's regularly playing there.
Resident DJ Annie G plays thumping deep and sexy house.
Harry Slack DJ is well established in the Drum & Bass scene and has recently found a passion in the bass heavy Fidget and Jackin style house.
International guest DJ's visiting the island love to play in the intimate environment of Fubar including Bora Bora Ibiza Resident DJ Akipa who now makes a monthly Fubar mix on soundcloud.
Keeping it closer to home 'FuFam' members who can often be seen behind the decks include:
DJ Darragh Casey, DJ Howie, DJ Dave King, DJ Rory Gallagher, DJ Rob Gritton, DJ Guy Fidelity, DJ Kaonashi and many many more.
Fuber DJs Guest book
Fubar photo galleries
Convienently only 30m from the Full Moon Beach.
Fubar location map:


text:
Hey all, ive got 3 work emotion xd9 18x9 +43 wheels that are 5x114.3. THe wheels are in good shape, i cracked the 4th one and im looking to change up styles. If you need one or want to buy all 3 let me know. These wheels are like $3000 new and used sets are usally $1600-2000. ill sell them individually or all 3 to someone looking to find a 4th and make a cheap set. shoot me some texts for pics or more info. I have no problem shipping them. They do clear brembos! 3302240086. They look like these at the link below.
Ill make a good deal on the 3. send me some offers!

domain: hobby


TDM Systems has its headquarters in Tübingen, Germany and is the leading software provider for managing tool data in metal cutting industry. The company is the competence center for tool management within SANDVIK Group, of which TDM Systems is a 100% subsidiary. This allows TDM Systems to rely on the know-how of internationally leading tool manufacturers and participate in their customer projects. The focus of TDM Systems is on solutions and services for the entire life cycle of tool data.
FORCAM is one of the undisputed pioneers of the German Industrie 4.0 movement. 15 years ago, FORCAM celebrated its debut and first deployment at Mercedes-Benz and launched thereafter a career developing solutions that would not only benefit global manufacturing but change it. Driven by passion FORCAM expanded over the years to key manufacturing economies and grew its partner network to become the most innovative IT solution provider in the industry.
Founded in the early 40’s by Friedrich Kelch in Germany KELCH is a great company offering high precision tool holders ,tool presetting machines, shrink fit machines and workpiece measurement machines.
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