Latex For Less Mattress and Pillows
Latex For Less Mattress claims it is the most natural mattress on the market. The mattress’ designers claim it is made only from organic cotton, wool natural latex, other natural materials. However, there is a bit of a controversy regarding whether or not the mattress is made from latex. In fact, the product’s advertising is more focused on sustainable materials rather than latex, so you should be on the lookout for any false claims.
Latex for Mattress Review
The Latex For Less mattress may be the right choice if you are looking for an alternative mattress. The mattress is reasonably priced and doesn’t release harmful toxic toxins. It is also great in reducing disturbances to your spouse. The mattress has soft sides that are suitable for sleepers who are light and one that is firm for heavier sleepers. You can choose between a natural cotton/wool cover or a latex foam layer to meet your needs.
This mattress comes with a generous 120-night sleep trial, which means you can return the product for no cost if you aren’t happy with it. The trial isn’t very long but the company suggests that you utilize the mattress for no more than 30 nights. This is when your body adjusts and the latex becomes more comfortable. You can also purchase a mattress with lifetime warranty. This means that you won’t need to change your mattress for many years to come.
Latex For Mattress Toppers That Cost Less
The latex for less Mattress Topper is an excellent way to add comfort to your mattress without the cost of memory foam or other synthetic materials. It is made of aerated Talalay latex and features a soft organic cotton cover. Latex is extremely quiet and can be used to make noise if you’re placing weight on it. It comes in six sizes that are standard and comes with free shipping throughout the contiguous U.S. and comes with five-year guarantee.
A latex mattress topper can be an affordable option to purchase a top-quality mattress. These toppers are usually one to three inches thick and are durable and last longer than other mattress toppers. They fit snugly to the body when you sleep and relieve pressure on sensitive areas. The most cost-effective option for budget-conscious people is the Dunlop latex mattress topper. However there are a few downsides to latex toppers.
Latex For Less Pillow
If you’re in search of a latex pillow that won’t break the bank, consider a Latex For Less Pillow. The company makes latex pillows using sustainable rubber trees. The sap that is milky is turned into a foam consistency before being molded into a pillow. These products typically carry five years of warranty. There are other advantages to pillows made of latex, such as an incredibly cool, comfortable feeling and long-lasting.
This brand creates a pillow made of latex that is made of natural materials like latex. This natural material is known for its bounce and breathability. Latex pillows are soft and comfortable, so those who sleep on their backs might like them. In addition to being soft pillows, they can assist in relieving pain due to improper posture. If you’re a stomach sleeper then you must purchase a pillow that has the proper support and density to reduce back and neck pain.
A pillow made of latex is expensive, but is worth it. The pillows last three to four years. Latex pillows are made from rubber trees, and they can be irritable or allergic. Although latex pillows can also be made from natural materials such as rubber trees, they’re usually blended with polyurethane foam. These blends reduce the durability of pillows made of latex and may also contain volatile organic compounds that can cause allergic reactions and breathing issues.
Latex For Less Topper Reviews
Latex For Less is a well-known brand that produces organic latex mattress toppers. Their 3-inch mattress topper is significantly cheaper than other brands. A three-inch latex mattress topper is priced at $110 instead of $175 you compare it to other brands. The topper is made by a Sri Lankan firm which could account for the lower price than American-made toppers made from latex.
The PlushBeds latex topper is a firm, but soft option that offers an incredibly comfortable sleep. It comes in three and two-inch thicknesses and comes with a natural cotton cover. The firmer version is more designed to fit back and side sleepers, while its soft construction keeps you cool. The natural wicking characteristics that wool and latex have allow the latex topper to conform to your body. This makes it ideal for hot sleepers.
Latex is breathable and doesn’t trap heat like memory foam does. It’s hypoallergenic, which means it doesn’t trigger sweating or hot flashes. It’s also made of natural latex and does not contain any harmful chemicals or allergens. The Latex For Less Topper can be used as a mattress topper in any position. Consumer Reports has rated it five stars and the reviews are all positive.
Sleep On Latex Vs Latex For Less
The main difference between a Sleep On Latex mattress and a cheaper latex mattress is cost. Sleep On Latex costs little more than half as more than its less expensive counterpart however it is the most robust mattress. It is also made in America and sold on the internet. The company ships from Illinois and offers free shipping within the continental U.S. but has to pay extra for shipping to Canada, Alaska and Hawaii.
Latex mattresses have a very different feel than any other foam mattress. You may notice some sinkage when you lie on a memory foam mattress, however, a mattress made of latex is more durable and bounces back faster. A mattress made of latex can offer motion-seclusion. Sleep On Latex has two firmness levels. The most well-known is the medium. Firm is the best choice for stomach and back sleepers, whereas medium to soft is more suitable for side sleepers.
Zenhaven, Sleep on Later, and Sleep on a Latex for Less mattresses have different certifications. Zenhaven is certified by GOTS and Sleep on Latex is certified by Oeko-Tex Standard 100. These certifications ensure that the products are made from quality materials. A latex for less mattress is more durable and responsive than a less expensive counterparts. Also, latex mattresses are generally more comfortable for people with back pain or other issues.
Latex For Less Complaints
If you haven’t yet tried a Latex For Less mattress, you should consider returning it for a full refund. To obtain an authorization number to return the mattress, and instructions on how to pack your mattress, you can reach out to the company. Amazon will arrange for a shipping company that will pick up your mattress for free within 30 days of purchase. You can also exchange your mattress for a new one and have your purchase price returned. However, you should be aware that your warranty will cover only the first 120 nights, and you can only return it for a full refund within 30 days.
Latex for Less mattresses are custom-made in the USA and delivered in boxes. It could take anywhere from three to seven days to craft your mattress. It can take up to a week for it to arrive. Because it is made of natural materials, it’s likely to contain a small amount of off-gassing. That means you’ll need to wait at least 12 hours before laying on it. If you’re heavier than average, you might need to buy an additional mattress topper.
Review of the Latex for Less Mattress Topper
The best mattress toppers are an excellent way to improve the comfort of your mattress. Even if your mattress is firm, a latex mattress topper can ease pressure points around your joints, and help ease some of the discomfort that comes with sleeping on an uncomfortable mattress. You can purchase a mattress topper made of latex separately or as a part of your mattress. To reap the maximum benefits you should combine the topper made of latex with a mattress made of latex for the most restful sleep possible.
In addition to being comfortable as well as its convenience, Latex For Less mattress toppers are inexpensive. They cost from $70 for a twin bed to $600 for a split King. Prices for the various sizes range from less than $300 to $200, depending on the time of year. While latex toppers are breathable, memory foam ones are not. They offer additional cushioning, so they are ideal for those who already have a latex mattress but prefer a smoother surface.
Latex For Less Vs Avocado
While both brands are excellent for back support One of the biggest differences between them is their cooling properties and density. While latex is naturally cool, memory foam absorbs energy. It is more responsive and adapts to your body and provides support that lasts. Avocado Latex’s Convoluted Latex is what makes the Avocado Latex mattress different. It makes use of lasers to cut the foam into concave peaks which reduces motion transfer. As opposed to memory foam latex is naturally bouncy and conforms to your body’s hard areas and provides a comfortable support system and helping to prevent back pain.
Avocado Latex Mattress is an organic, all-natural mattress manufactured in Los Angeles. It’s GREENGUARD certified. This model is perfect for people who sleep on their sides and those who sleep in combination alike. It’s also eco-friendly, which makes it the ideal choice for those who prefer natural materials. However, the Avocado mattress is more expensive than other latex mattresses on market. For a queen, it retails for $1,800.


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How to use the Paint Bucket in Photoshop.
The Paint Bucket tool is a workhorse for creative people looking to bring splashes of colour to their work in record time.
You can work quickly with the Paint Bucket tool, filling an area with your choice of two changeable colours: a foreground colour and a background colour.
When paired with dozens of selection tools and versatile layer options, the bucket is a reliable accessory for creating complex collages of colour.
Advanced Paint Bucket tool options.
The trusty Paint Bucket can do more than just cover an area — it has plenty of settings to help you to create a smarter, better fill.

domain: artistic


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1636: Mission to the Mughals by Eric Flint, Griffin Barber
1636: Mission to the Mughals Eric Flint, Griffin Barber ebook
Visit Here http://bubblebooks.xyz/?book=1476782148. Kartoffelmus.de - Dein Kochshop im Netz. 1636: Mission to the Mughals (Ring of Fire). This timeline of Christian missions chronicles the global expansion of Christianity through a .. Read book reviews & excerpts, watch author videos & more. 1636: Mission to the Mughals (bk 23 in the 1632/Ring of Fire series. Shadow of Victory (Honor Harrington). The latest entry in the multiple New York Times best-selling Ring of Fire series created by Eric Flint. As difficulties mount, Caine becomes aware that the mission his superiors sent him to perform may not be the one . A Scandal in Battersea (Elemental Masters). Missionaries begin work in Benin, Nigeria; 1517 - The Mughal Rulers of Delhi opened the door of Bengal to Christian missionaries . By Eric Flint and Griffin Barber. January 2016: 1636: The Mughal Mission, with Griffin Barber. December 2015: the mass market edition of 1636: The Viennese Waltz is coming out. Find out more about 1636: Mission to the Mughals by Eric Flint, Griffin Barber at Simon & Schuster. [DOWNLOAD] PDF BOOK 1636: Mission to the Mughals (Ring of Fire) New · [ DOWNLOAD] PDF BOOK 1636: Mission to the Mughals (Ring of Fire). 1636 - The Dominicans of Manila (the Philippines) organize a missionary expedition to Japan.

domain: literature


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Punjab Chief Minister Amarinder Singh has written to Prime Minister Narendra Modi, urging him to evaluation the UGC directive that mandated ultimate examinations in faculties and universities by September-end.
The College Grants Fee (UGC) on July 6 had introduced that final-year examinations in universities must be carried out by the tip of September, deferring the schedule from July in view of a spike in COVID-19 circumstances within the nation.
“UGC could also be requested to reiterate its earlier issued pointers of 29th April 2020, whereby it had been clearly talked about that the rules had been advisory in nature and every state/college would chart out its personal plan of motion bearing in mind the problems pertaining to the COVID-19 pandemic,” Mr Singh mentioned in his letter to PM Modi.
He has additionally sought permission to let the Punjab authorities adhere to its July three resolution on cancellation of college and faculty examinations in view of rising novel coronavirus circumstances.
Bearing in mind the COVID-19 state of affairs and attendant problems with security of scholars and workers, the state authorities had on July three determined to cancel all pending undergraduate and postgraduate final-term examinations and to advertise college students on the premise of efficiency in earlier years and semesters, an official launch quoting the Chief Minister mentioned on Saturday.
“As well as, we’ve additionally allowed conduct of examinations for the aim of enchancment of grades for college students, as soon as the state of affairs turns into conducive,” he mentioned.
“This is able to guarantee educational credibility, profession alternatives, future prospects and truthful and equal alternative for college kids in each city and rural areas,” Mr Singh burdened.
The state greater training minister had written to the Union Human Useful resource Growth Minister on July 10 on this regard, the Chief Minister mentioned in his letter.
Mr Singh famous that the “battle in opposition to COVID-19 has entered a big section with the variety of circumstances growing exponentially and varied research pointing to peaking of circumstances over the following few months”.
“In view of this rising development of circumstances, I’m not positive whether or not the state of affairs will probably be conducive for conducting offline bodily examinations by September,” he mentioned.
Conducting bodily examination may even contain large logistical and operational challenges, particularly in view of the big variety of faculty and college buildings, and hostels having been taken over by district administrations for COVID-19 administration functions, the Chief Minister mentioned.

domain: news


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A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes.
Bottom Line: Markers of inflammation and oxidative stress, including high-sensitivity C-reactive protein, interleukin 6, interleukin 18, tumour necrosis factor-alpha, adiponectin, thiobarbituric acid reactive substances, oxygen radical antioxidant capacity, oxidized LDL and urinary isoprostanes, were also measured at fasting and in the postprandial period.There were no diet-related effects on glycaemic control or glycaemic or insulinaemic responses to the test meal.There was a postprandial decline in adiponectin concentration (P = 0.009), but no effect of dietary intervention.
Affiliation: The Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK; Department of Diabetes, Aberdeen Royal Infirmary, Aberdeen, UK.Show MeSH
Related in: MedlinePlus
Mentions: For nine volunteers, IL-18 concentrations were below the limit of assay detection (9 pg/ml), but for those subjects with detectable IL-18 at baseline (n = 18), both fasted and postprandial values were higher (P = 0.001) following standard dietary advice than either the habitual or oat-enriched diet. There was no effect of diet on fasting or postprandial concentrations of other markers of inflammation or oxidative stress (Table6). However, there was a postprandial decline (P = 0.009) in adiponectin concentrations following the standard test meal. This was not affected by chronic diet (Fig.3).
Affiliation: The Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK; Department of Diabetes, Aberdeen Royal Infirmary, Aberdeen, UK.

domain: medical


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Be Like No One.
ATTENTION: a microSD card (sold separately) with free storage space of minimum 32GB is required to download this game, plus 1GB on the system memory. You must have your microSD card inserted before beginning the download.
NOTE: All multiplayer servers for WWE 2K18 will be shutdown as of 05/31/2019. After that time, all game functions requiring online servers will no longer function.

domain: game


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Mayonnaise is a staple of summer. It’s the glue that holds together the potato salad, coleslaw, deviled eggs, and the classic BLT. But you may have asked yourself, “should I use mayonnaise or salad dressing, and what’s the difference, anyway?”
Mayonnaise is a mixture of eggs, oil, lemon juice or vinegar, and spices. While liquid and oil typically don’t mix, they will with a little help. The lecithin in the eggs acts as an emulsifier and allows the fat in the oil to bond with the liquid creating a creamy texture. According to the U.S. Food and Drug Administration (FDA), mayonnaise must contain at least 65% vegetable oil by weight to be labeled as “mayonnaise.” This takes us to the difference between mayonnaise and salad dressing.
Salad dressing is made with the same basic ingredients as mayonnaise. However, it has more water by weight than oil. It is also sweeter than mayonnaise, usually with high fructose corn syrup. Comparing the same 2-Tablespoon serving, regular mayonnaise has 180 calories, 3 grams saturated fat and 0 grams carbohydrate while salad dressing has 80 calories, 1 gram saturated fat and 4 grams carbohydrate. So which should you choose? That depends on whether or not you’d rather have lower saturated fats or lower carbs. You might look for the “light” versions for a happy medium. To make things even more complicated, you can now buy olive oil and avocado oil mayonnaise. It’s worthwhile to note that these are often mixed with other oils to mask any strong flavoring. The type of oil doesn’t necessarily make them any healthier but make sure to compare the labels when shopping. You can make your own mayonnaise at home, but the United States Department of Agriculture (USDA) says to buy pasteurized eggs or egg product and store the mayonnaise in the refrigerator for no longer than four days.
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1 Tablespoon mayonnaise or salad dressing
4 teaspoons sugar (or 2 packets of favorite sugar substitute)
1 large sweet apple, diced
In bottom of mixing bowl, blend mayonnaise, lemon juice and sugar with a spatula. Add apples, mixing them with dressing as they are cut to prevent browning. Stir in celery, raisins and walnuts. Cover and refrigerate.
Yield: 4 (1/2 cup servings)
Nutrition Facts (per serving using mayo and sugar): 100 calories, 5 grams fat, 25 milligrams sodium, 14 grams carbohydrate, 2 grams fiber, 1 gram protein
Source: FDA CFR – Code of Federal Regulations Title 21
Smith is nutrition and wellness educator for the University of Illinois Extension, McLean County. Contact her at 309-663-8306.

domain: food


The Cassini team released some incredible images earlier this week of the Saturn system during equinox, and followed up with this beauty of a crescent moon Rhea beneath the rings of Saturn. NASA has also put together a multimedia presentation of recent pictures of Saturn, set to music, and it is stunning. Run, don’t walk and click here to watch. (Flash required)
With these great images, it is no wonder that the leader of the Cassini imaging team, Carolyn Porco has been presented with an award for her work, the Lennart Nilsson Award for photography for capturing “worlds that are otherwise hidden from human sight.” The award committee’s citation reads:
“Carolyn Porco combines the finest techniques of planetary exploration and scientific research with aesthetic finesse and educational talent. While her images, which depict the heavenly bodies of the Saturn system with unique precision, serve as tools for the world’s leading experts, they also reveal the beauty of the universe in a manner that is an inspiration to one and all.”
Congratulations Dr. Porco!
Here’s some info about the image above:
Rhea (1528 kilometers, 949 miles across) is near the middle of the bottom of the image. This view looks toward the northern, sunlit side of the rings from about 4 degrees above the ringplane.
The image was taken in visible light with the Cassini spacecraft wide-angle camera on Aug. 24, 2009. The view was obtained at a distance of approximately 1.6 million kilometers (994,000 miles) from Saturn and at a Sun-Saturn-spacecraft, or phase, angle of 137 degrees. Image scale is 95 kilometers (59 miles) per pixel.


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M.S. Pharmaceutical Sciences
Chemistry and Biochemistry
College of Science & Mathematics
Caputo, Gregory A.
Committee Member 1
Vaden, Timothy D.
Committee Member 2
Perez, Lark J.
microbials, antimicrobial resistance, antimicrobial peptides, ionic liquids, ponericin L1
Medicinal and Pharmaceutical Chemistry
Non-traditional antimicrobials have been an area of great interest due to the increasing prevalence of antimicrobial resistance (AMR) in bacteria. Antimicrobial peptides (AMPs) & ionic liquids (ILs) are two examples that have been investigated as a potential solution. Most AMPs are naturally derived & exhibit high selectivity against bacterial targets over host cells. The venom-derived peptide, ponericin L1 from Neoponera goeldii, was used to investigate the role of cationic residues & net charge on peptide activity. Using both in vitro & microbiological methods, L1 peptide & derivatives exhibited an alpha-helical conformation with enhanced binding to lipid vesicles containing anionic lipids & low hemolytic activity. Net charge & identity of the cationic groups on the peptide were shown to play a significant role in antimicrobial activity. ILs have also been investigated in combination with antimicrobial compounds to fight AMR. Imidazolium chloride-based ILs with differing alkyl tails & commercially available antibiotics were used to examine the potential for synergistic effects on multiple bacteria. Analysis of the IL data indicates that length of the alkyl chain plays a crucial role in antimicrobial activity & cytotoxicity. A synergistic effect was exhibited while showing low cytotoxicity when tested in a mammalian cell culture model.
Senetra, Alexandria S., "Investigation of the sequence-structure-activity relationship in Ponericin L1 from Neoponera Goeldii & synergistic interactions of ionic liquids and antimicrobials to improve efficacy" (2020). Theses and Dissertations. 2842.


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RadiantGrid adds Softel Swift VTX subtitle processing
March 15, 2010
RadiantGrid Technologies, a provider of transcoding technology, has announced a partnership with Softel, providers of captioning technology that will add subtitle processing to RadiantGrid’s transcoding platform.
Through the RadiantGrid platform users will now be able to handle subtitle and closed-caption processes with Softel’s Swift vTX technology, which provides encoding/transcoding, enabling subtitle and caption processing across a variety of output and file formats, including Open, Line 21, DVB, streaming VOD and Web formats.
RadiantGrid users will now be able to handle their subtitling and closed-captioning processes simultaneously with other transcoding processes within the platform, effectively reducing the time needed for content to be converted and processed for deployment.
RadiantGrid’s management of media in file-based workflows combined with Softel’s subtitling and captioning capabilities will help content providers across a broad range of distribution platforms and formats.
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ABS & Its Conservation Initiatives
Species begonias have evolved on their own over many years, to adapt to the specific natural habitat where they live. Unfortunately, because of worldwide impacts such as global climate change and deforestation, Begonia species are increasingly vulnerable in their native habitats. Further, some species are at risk due to “poaching” of these remarkable begonias for sales to collectors. All of this makes it difficult, or impossible, for species to repopulate, and place these begonias in a vulnerable or endangered conservation status.
As researchers make field expeditions to study begonias, they witness first-hand the destruction of natural habitats.
There are several ways to learn about the vulnerability of Begonia species. A great place to start is the International Union for Conservation of Nature, which publishes the Red List of Threatened Species and categorizes vulnerability of species.
ABS Efforts to support Conservation of Endangered Species
ABS, through its membership, generous volunteer work, and financial donations, supports conservation efforts worldwide to research Begonia species, including identifying conservation issues impacting Begonia species.
ABS provides grants for a range of conservation initiatives, from supporting field expeditions of Begonia researchers to supporting the efforts of botanical gardens to grow Begonia species outside of their natural habitats (ex situ), such as that done by the Ft. Worth Botanic Garden and its Begonia Species Bank, the largest Begonia collection in North America.
How can you, or your branch, be a part of this effort?
One simple and easy way to play a part is to Donate to the American Begonia Society’s diverse efforts towards conservation.
There are also other ways YOU can participate in, and support conservation:
- Read and learn about Begonia species and consider helping these stunning plants continue to grow into the future, should they disappear in their natural habitats.
- Save Our Species is a program that encourages all ABS members, especially those new to growing Begonia species, to participate, learn how to grow and care for them, and enjoy the beauty of these begonias.
- Seeds for Conservation is a program led by ABS members to grow and produce seed of endangered species.
- Join one of our local branches and benefit from their educational programs and publications offered by the American Begonia Society.
- Attend our Annual Convention to meet others who are interested in begonias, and conservation.
- Learn more about where Begonia species are found in nature and about those researching and monitoring the environments.
- Read our ABS member publication The Begonian.
- As a member of ABS, you can purchase Begonia seeds through our Clayton M. Kelly Seed Fund.


Highlights for Accubanker D63 Counterfeit Money Detector
Protect your money with this dual compact counterfeit detection system. Check for counterfeit banknotes using simultaneously ultraviolet and watermark detections systems. Although this portable counterfeit detector is equipped with two 9 Watts UV lights, it is specifically designed to protect the user from direct eye exposure to the UV rays. Clearly visualize the fluorescence of the security thread in U.S. notes or fibers and other features present in other currencies, credit cards, special documents, etc. The enhanced watermark screen allows an easy verification of illustrations. The compact and small design of the detector saves space on your desk or counter.
Product InformationCounterfeit Detection Technology: Ultraviolet
WarrantyLimited Warranty: Lifetime
Magnetic Indicator (Green LED)
General InformationProduct Type: Detection SystemManufacturer Part Number: D63Manufacturer Website Address: http://www.accubanker.comManufacturer: AccuBANKERProduct Model: D63Product Name: D63 Counterfeit Money DetectorBrand Name: AccuBANKER
Additional Information Power Switch Magnetic Head UV/WM Selector Button Illumination: 200 ~ 800 lx Ambient Humidity: ? 85% Large Watermark Screen Ambient Temperature: 0?C to 40?C (32?F to 104?F)
Physical CharacteristicsHeight: 4.1"Width: 10.6"Depth: 4.7"
Power DescriptionInput Voltage: 110 V ACPower Consumption: 18 W
Product InformationApplication/Usage: Credit CardFeatures: Portable
Accubanker D63 Counterfeit Money Detector
Ultraviolet, Watermark, Magnetic Ink


Closet Environmental: Carnival of the Green #117! by Alina
"Today, we’ll be touring the internet jungle, looking for the most interesting specimens of environmental blogging. Please feel free to admire the diversity of the wildlife. You are also encouraged to feed the bloggers with ideas."
DeSmogBlog: Denial-a-Palooza is a Media Hit by Richard Littlemore
"Mainstream media seem to have caught up with climate change denial (caught up with reality, really), just in time to humiliate the assembled "sceptics" at the Heartland Institute's 2008 International Conference on Climate Change."
EcoStreet: Turn your garden into an eco-friendly food garden by Tracy Stokes
"If you’re into sustainable living, or getting into it, the best way to green your food is to start growing your own vegetables, herbs and fruit. You may think that’s not possible if you live in a flat in the city. Well, not only is it possible, but it’s a great stress-buster and a good way to cut food miles."
Grist: The natural resource curse is such a bitch by Nathan Wyeth
"Speaking today at Brown University's Watson Institute, Ross emphasized that when developing economies are dominated by oil and don't diversify into things like textiles and manufacturing, women don't go into the labor force, their social status remains low, and -- because women are stuck at home or in informal employment -- their political movements remain nascent."
The Greener Side: Why not having a car stinks by Elsa
"Car-sharing is great. I use rent-by-the-hour Zipcar and live in a small big city where I can get around on two feet or two wheels for most things. Most Americans probably can't imagine getting by without a car in unsustainable subdivision land."


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Cancer Diagnostic and Predictive Biomarkers 2018View this Special Issue
Review Article | Open Access
Min Jiang, Xuelian Li, Xiaowei Quan, Xiaoying Li, Baosen Zhou, "Clinically Correlated MicroRNAs in the Diagnosis of Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis", BioMed Research International, vol. 2018, Article ID 5930951, 14 pages, 2018. https://doi.org/10.1155/2018/5930951
Clinically Correlated MicroRNAs in the Diagnosis of Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
(1) Background. Non-small cell lung cancer (NSCLC) has a high mortality rate. MiRNAs have been found to be diagnostic biomarkers for NSCLC. However, controversial results exist. We conducted this meta-analysis to evaluate the diagnostic value of miRNAs for NSCLC. (2) Methods. Databases and reference lists were searched. Pooled sensitivity (SEN), specificity (SPE), and area under the curve (AUC) were applied to examine the general diagnostic efficacy, and subgroup analysis was also performed. (3) Results. Pooled SEN, SPE, and AUC were 85%, 88%, and 0.93, respectively, for 71 studies. Multiple miRNAs (AUC: 0.96) obtained higher diagnostic value than single miRNA (AUC: 0.86), and the same result was found for Caucasian population (AUC: 0.97) when compared with Asian (AUC: 0.91) and Caucasian/African population (AUC: 0.92). MiRNA had higher diagnostic efficacy when participants contained both smokers and nonsmokers (AUC is 0.95 for imbalanced group and 0.91 for balanced group) than when containing only smokers (AUC: 0.90). Meanwhile, AUC was 0.91 for both miR-21 and miR-210. (4) Conclusions. Multiple miRNAs such as miR-21 and miR-210 could be used as diagnostic tools for NSCLC, especially for the Caucasian and nonsmoking NSCLC.
Lung cancer is the principal cause of cancer-associated deaths among males both in developed and in developing countries, and it has exceeded the breast cancer becoming the major cause of cancer-related deaths in females in the developed countries . Non-small cell lung cancer (NSCLC) is a major type of lung cancer that is responsible for 85% lung cancer-associated deaths. Smoking has been recognized as a primary environmental risk factor of lung cancer. However, only a small number of smokers will develop into lung cancer patients.
MicroRNA is a group of 19–22 nucleotide, small, single-stranded, and conserved noncoding RNA that acts as a regulator of gene expression at both the posttranscriptional and the translational levels through acting on the 3′-untranslated region (UTR) of messenger RNA (mRNA) . MiRNAs play important roles in various biological processes associated with the tumorigenesis such as the cellular proliferation, differentiation, metabolism, and apoptosis [3, 4]. It is available to isolate the miRNAs from the clinical specimens including the plasma, serum, sputum, and tissue. Meanwhile, it has a high stability. Due to these advantages, the miRNAs are increasingly becoming an ideal tool for the detection of NSCLC.
Recently, a series of articles have shown that different miRNAs might be applied to detect the NSCLC [5–7]. For example, miR-21, an oncogenic miRNA, has been shown to be overexpressed in lung cancer as well as other various human tumors . Upregulation of miR-21 could promote the tumorigenesis of lung cancer through inhibiting the apoptosis process and negatively regulating the Ras/MEK/ERK signal pathway . High miR-210 expression was correlated with the increased lymph node metastasis and a poor prognosis in patients with NSCLC . Both these two, miR-21 and miR-210, have been explored to be used as diagnostic tools for NSCLC, no matter whether they are applied in combination with other miRNAs or alone [11–14]. However, as a result of the small sample sizes, the different miRNAs profiling, and the differences of the specimen and ethnicity, inconsistencies existed among studies that had examined the diagnostic value of miR-21, miR-210, and other miRNAs for NSCLC. Therefore, a meta-analysis was performed to assess the performance of miRNAs in the detection for NSCLC.
2. Materials and Methods
2.1. Search Strategy
Our meta-analysis was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched PubMed, Google Scholar, Chinese National Knowledge Infrastructure (CNKI), Embase, and Medline to find all associated articles in order to investigate the potential utility of miRNAs as diagnostic tools for NSCLC. The combination of the Medical Subject Headings (MeSH) and the keywords (“lung neoplasm” OR “lung malignancy” OR “lung cancer”) AND (“miRNA” OR “microRNAs”) AND (“ROC curve” OR “sensitivity” OR “specificity” OR “diagnosis”) was used (updated to April 5, 2017). The reference lists of the reviews were also searched to obtain all the acceptable articles.
2.2. Study Selection
A series of criteria were applied for study inclusion and exclusion. For inclusion, the criteria were as follows: (1) patients with NSCLC; (2) the type of the controls being healthy controls (HC) or patients with benign pulmonary diseases (BPD); (3) assessing the diagnostic value of the miRNAs; (4) the possibility of extracting or calculating TP, FP, FN, and TN from the articles. For exclusion, the criteria were as follows: (1) studies that were duplicate publications, reviews, or unrelated; (2) studies without complete data.
2.3. Data Collection and Quality Assessment
Two authors collected the data independently as follows: the first author, publication year, and participant demographic characteristics (ethnicity, sample size, mean or median age, smoking status, the types of the controls, and the testing method of controls and cancer); types of the specimen; miRNA profiling and the data used for this meta-analysis (SEN, SPE, TP, FP, FN, and TN). The quality of these articles were assessed with the QUADAS-2 guidelines .
2.4. Statistical Analysis
All the statistical analyses were conducted by RevMan 5.3 (version 1.4) software and STATA 11.0 (STATA-Corp, College Station, TX, version 11.0) software. The heterogeneity among the selected studies was assessed through the Q test and the I2 value . The P value for the Q test being less than 0.05 or the I2 ≥ 50 % demonstrated that there was heterogeneity among the included studies. The pooled SPE [TN/(FP+TN)], SEN [TP/(FN+TP)], diagnostic odds ratio (DOR) [PLR/NLR], the negative likelihood ratio (NLR) [(1-SPE)/SPE)], the positive likelihood ratio (PLR) [(SEN/(1-SEN)], and their 95% confidence intervals (95% CIs) were evaluated by a bivariate random-effect-regression model. The SROC curve was constructed and the AUC value was calculated too. A Fagan nomogram was also constructed to evaluate the clinical utility of miRNAs in the diagnosis of NSCLC. Subgroup analyses (grouped by miRNA profiling: single and multiple; smoking status: only smokers, smokers, and nonsmokers (imbalanced between groups), smokers and nonsmokers (balanced between groups), and unknown smoking status; specimen: serum, plasma, whole blood/blood cell, and not blood; ethnicity: Asian, Caucasian, and Caucasian/African; control-type: BPD, HC, and BPD/HC; stage: early stage and no early stage; and case number: large (≥ 50) and small (< 50)) and meta-regression analysis were used to identify the potential sources of the heterogeneity. The Deeks’ funnel plot asymmetry test was also applied to explore the publication bias, with the P value less than 0.01 considered significant .
3.1. Literature Search and the Studies’ Characteristics
As shown in Figure 1(a), 2594 eligible articles were included, of which 2145 articles were removed as unrelated and duplicate articles. And then 370 reviews were also excluded, leaving 79 articles with full texts, and another 21 articles were then removed through carefully reading: 14 articles met the exclusion criteria and 7 articles did not have the complete data. Ultimately, 58 articles [5–7, 11–14, 18–68] with 71 studies published from 2009 to 2017 including 9,099 participants (5111 cases with NSCLC and 3988 controls from the healthy individuals and the patients with the benign pulmonary disease (BPD)) were included. The main characteristics of these 71 studies were shown in Table 1. Wang Y’s article , Fan LH’s article , Nadal E’s article , Tang DF’s article , Razzak R’s article , Wang W’s article , Yu L’s article , and Xing LX’s article  included 2 studies. Bediaga’s article  included 3 studies, Wang C’s article  included 4 studies, and the remaining articles [5, 6, 11–13, 20–27, 29–31, 33–44, 47–51, 53–67] included 1 study, respectively. Meanwhile, there were 18 studies [13, 14, 28, 31, 33, 45, 46, 48, 54, 56, 63, 65, 66] performed in Caucasian, 11 studies [18, 19, 21, 23, 27, 29, 30, 38, 44] performed in Caucasian/African, and 1 study  performed in African populations; the remaining studies were performed in Asian populations. A total of 50 studies detected the miRNAs in blood such as the whole blood, plasma, serum, and peripheral blood mononuclear cells (PBMC) [6, 7, 11, 20–24, 26, 29–35, 37, 39–42, 44–47, 49–54, 56–64, 66–68], while the remaining studies were detected in nonblood samples (7 tissue [5, 25, 28, 55, 68], 1 pleural effusion , 12 sputum [12, 14, 18, 19, 27, 36, 38, 48, 65], and 1 BAL ). We evaluated 45 studies for assessing the diagnostic value of multiple miRNAs and 26 studies [5, 6, 11, 20, 22, 24–26, 33–37, 39–41, 43, 47, 50, 51, 55, 57, 58, 60, 67, 68] of single miRNA.
miR-451, miR-1290, miR-636, miR-30c, miR-22-3p, miR-19b, miR-486-5p, miR-20b, miR-93, miR-34b, miR-185, miR-126-5p, miR-93-3p, miR-1274a, miR-142-5p, miR-628-5p, miR-486-3p, miR-425, miR-645, miR-24; miR-96, miR-450a, miR-183, miR-9, miR-577, Let-7i, miR-27b and miR-34a; miR-26a, miR-140-5p, miR-195, miR-30b;miR-126, miR-423, miR-15a, let-7d, let-7i, miR-22, miR-98, miR-19a, miR-20b, miR-324, miR-574, miR-195, miR-25, let-7e, let-7c, let-7f, let-7a, let-7g, miR-140, miR-339, miR-361, miR-1283, miR-18a, miR-26b; 1: only smokers; 2: smokers and nonsmokers (smoking status was imbalanced between groups); 3: smokers and nonsmokers (smoking status was balanced between groups); 4: unknown smoking status.
N: number; HC: healthy control; BPD: benign pulmonary disease; miR: microRNA; SEN: sensitivity; SPE: specificity; FQDs: fluorescence quantum dots; BAL: bronchoalveolar lavage.
The quantitative real-time polymerase chain reaction (qRT-PCR) and digital polymerase chain reaction (digital PCR) were used in these studies to test the expression levels of different miRNAs, and the most common reference miRNAs were RNU6B, miR-39, and miR-16. Quality of the enrolled studies summarized in Figure 1(b) was generally good.
3.2. Pooled Diagnostic Performance
Significant heterogeneity was obtained since I2 values for SEN and SPE were 89.05% (95% CI: 87.07-91.03%) and 79.59% (95% CI: 75.18-84.01%), respectively. Therefore, a random-effect model was conducted for this study. Results indicated the pooled SEN and SPE for these 71 studies were 85% (95% CI: 82-88%) and 88% (95% CI: 85-90%), respectively (Figure 2). The PLR and NLR were 6.9 (95% CI: 5.6-8.4) and 0.17 (95% CI: 0.14-0.21), respectively (Figure 3), the DOR was 40 (95% CI: 28-58), and the AUC was 0.93 (95% CI: 0.90-0.95) (Figure 4(a)).
3.3. Publication Bias
Results of the Deeks’ funnel plot asymmetry test showed that the publication bias did not exist in these studies as the funnel plot was symmetry (Figure 4(b)) and P value equaled 0.12.
3.4. Subgroup Analyses and Meta-Regression Analysis
Results of the meta-regression analysis demonstrated that the heterogeneity might be explained by miRNA profiling (P < 0.001) and case number (P < 0.05) for SPE and by miRNA profiling (P < 0.01) for SEN as described in Figure 5. The subgroup analyses were also conducted and the results were presented in Table 2. For the subgroups of smoking status, compared with the subgroup of only smokers (SEN: 80% (95% CI: 70-87%), SPE: 86% (95% CI: 77-91%), and AUC: 0.90 (95% CI: 0.87-0.92)), miRNAs had a higher diagnostic efficacy in the subgroups of smokers and nonsmokers (SEN: 88% (95% CI: 74-95%), SPE: 90% (95% CI: 73-97%), and AUC: 0.95 (95% CI: 0.93-0.97) for imbalanced groups and SEN: 83% (95% CI: 74-90%), SPE: 86% (95% CI: 80-90%), and AUC: 0.91 (95% CI: 0.88-0.93) for balanced groups). Subgroup analysis by specimen showed that studies with serum samples exhibited higher diagnostic accuracy with SEN: 91% (95% CI: 86-95%), SPE: 85% (95% CI: 79-89%), and AUC: 0.94 (95% CI: 0.91-0.95) than studies with plasma samples with the SEN: 82% (95% CI: 76-87%), SPE: 87% (95% CI: 83-90%), and AUC: 0.92 (95% CI: 0.89-0.94) and not blooding samples with the SEN: 80% (95% CI: 72-86%), SPE: 89% (95% CI: 85-93%), and AUC: 0.92 (95% CI: 0.89-0.94), respectively. When compared with the large sample size, miRNA might be a better diagnostic tool for small sample size with SEN: 88% (95% CI: 82-92%), SPE: 91% (95% CI: 88-94%), and AUC: 0.95 (95% CI: 0.93-0.97). In the subgroups for the ethnicity, the miRNAs obtained a better diagnostic value in the Caucasian populations with the SEN: 91% (95% CI: 86-95%), SPE: 92% (95% CI: 87-96%), and AUC: 0.97 (95% CI: 0.95-0.98), respectively, when compared with the Asian populations with the SEN: 82% (95% CI: 77-85%), SPE: 86% (95% CI: 82-88%), and AUC: 0.91 (95% CI: 0.88-0.93), respectively, and the Caucasian/African populations with SEN: 85% (95% CI: 72-93%), SPE: 87% (95% CI: 81-91%), and AUC: 0.92 (95% CI: 0.89-0.94), respectively. In the subgroups of the miRNAs profiling, the multiple miRNAs had a higher accuracy for diagnosing the NSCLC with SEN: 88% (95% CI: 85-91%), SPE: 91% (95% CI: 88-93%), and AUC: 0.96 (95% CI: 0.93-0.97), respectively, when compared with the single miRNA with the SEN: 77% (95% CI: 71-82%), SPE: 80% (95% CI: 77-84%), and AUC: 0.86 (95% CI: 0.82-0.88), respectively. miRNAs had a higher value to distinguish the NSCLC patients from healthy individuals with the SEN: 86% (95% CI: 82-89%), SPE: 88% (95% CI: 85-91%), and AUC: 0.94 (95% CI: 0.91-0.95) than controls with benign pulmonary disease with SEN: 84% (95% CI: 77-89%), SPE: 84% (95% CI: 80-88%), and AUC: 0.90 (95% CI: 0.87-0.92). Compared with other miRNAs, miR-210 and miR-21 were more often used as diagnostic tools. However, they were usually associated with other miRNAs. The sensitivity, specificity, and AUC were, respectively, 77% (95% CI: 72-81%), 93% (95% CI: 88-96%), and 0.91(95% CI: 0.88-0.93) for miR-210 with other miRNAs. The sensitivity, specificity, and AUC of miR-21 with other miRNAs were, respectively, 82% (95% CI: 77-86%), 87% (95% CI: 84-89%), and 0.91 (95% CI: 0.88-0.93).
No: the number of the studies; HC: healthy control; BPD: benign pulmonary disease; SEN: sensitivity; SPE: specificity; PLR: positive likelihood ratio; NLR:negative likelihood ratio; DOR: diagnostic odds ratio; AUC:area under the curve; no. of case: small (<50) and large (≥50).
S: smokers; NS: nonsmokers; imbalanced: the smoking status was imbalanced between groups; balanced: the smoking status was balanced between groups.
Due to the high mortality rate and low survival rate of NSCLC, there is an urgent need for the accurate detection method for the early detection of NSCLC especially for the nonsmoking NSCLC patients. Although miRNAs may have a high diagnostic accuracy according to the previous articles, the clinical utility of the miRNA for diagnosing NSCLC remains controversial. Compared with the previous meta-analyses [69–71], there were more studies and participants included in this meta-analysis. Our analysis showed the pooled SEN was 85% (95% CI: 82-88%), the pooled SPE was 88% (95% CI: 85-90%), and the AUC was 0.93 (95% CI: 0.90-0.95), suggesting that miRNAs had pretty high diagnostic value for NSCLC. Our results also showed that the pooled DOR was 40 (95% CI: 28-58), indicating that for an individual proved positive by miRNAs the chance of having NSCLC is 40 times higher than the negative ones. For the subgroup analyses, higher accuracy was observed in the multiple miRNA profiling when compared with the single miRNA, which was consistent with the previous conclusions [69–71]. MiRNAs might have a higher diagnostic efficacy for the nonsmoking NSCLC patients compared with the smoking ones. Meanwhile, differences were also observed among the Caucasian, Asian, and Caucasian/African populations. This result could be supported by the Wang H’s article . Furthermore, miRNAs from serum samples exhibited higher diagnostic value than miRNAs from other specimen. These results meant that combinations of various miRNAs may be better diagnostic tools than the single miRNA, and miRNA isolated from serum could have a higher diagnostic value for the Caucasian populations when compared with the Asian and Caucasian/African populations. Among the different multiple miRNAs, miR-210 and miR-21 associated with other miRNAs could be used for the detection of NSCLC. However, there were still some limitations that could not be neglected in this meta-analysis such as the heterogeneity among these 71 studies, the different methods in miRNA profiling, the possibility that some articles are missed or not published online.
Our meta-analysis showed the practicability of miRNAs for diagnosing NSCLC and demonstrated that the multiple miRNAs might have a relatively high diagnostic value for NSCLC compared with the single miRNA diagnosis. miR-210 and miR-21 could be used as effective tools through combining with other miRNAs. In addition, miRNAs, especially isolated from serum, had a better diagnostic accuracy in Caucasian populations than the Asian populations as well as the Caucasian/African populations. When compared with the smoking NSCLC patients, miRNAs might have a higher diagnostic efficacy for the nonsmoking ones. However, studies on the large samples are still demanded to verify our results.
|NSCLC:||Non-small cell lung cancer|
|SROC:||Summary receiver operating characteristic|
|AUC:||The area under the SROC curve|
|BPD:||Benign pulmonary disease|
|CNKI:||Chinese national knowledge infrastructure|
|PLR:||Positive likelihood ratio|
|NLR:||Negative likelihood ratio|
|DOR:||Diagnostic odds ratio|
|qRT-PCR:||Quantitative real-time polymerase chain reaction|
|PBMC:||Peripheral blood mononuclear cells|
|PRISMA:||Preferred Reporting Items for Systematic Reviews and Meta-Analyses|
Conflicts of Interest
The authors declare that there are no potential conflicts of interest.
Baosen Zhou, Xuelian Li, and Min Jiang conceived and designed this study. Min Jiang and Xiaoying Li searched the literature and analyzed the data. Xiaowei Quan contributed to the analysis tools and the statistical analysis. Min Jiang and Baosen Zhou wrote and revised the paper.
This study was supported by the National Natural Science Foundation of China (no. 81502878) and the Doctoral Research Project of Liaoning Province (no. 201601117).
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- L. Chen and H. Jin, “MicroRNAs as novel biomarkers in the diagnosis of non-small cell lung cancer: a meta-analysis based on 20 studies,” Tumor Biology, vol. 35, no. 9, pp. 9119–9129, 2014.
- Y. Huang, Q. Hu, Z. Deng, Y. Hang, J. Wang, and K. Wang, “Micrornas in body fluids as biomarkers for non-small cell lung cancer: a systematic review,” Technology in Cancer Research & Treatment, vol. 13, no. 3, pp. 277–287, 2014.
- H. Wang, S. Wu, L. Zhao, J. Zhao, J. Liu, and Z. Wang, “Clinical use of microRNAs as potential non-invasive biomarkers for detecting non-small cell lung cancer: A meta-analysis,” Respirology, vol. 20, no. 1, pp. 56–65, 2015.
Copyright © 2018 Min Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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|nutritional information (per serving)|
View full nutritional information
Hide full nutritional information
|amount per serving|
|% Daily Value*|
|Saturated Fat 6g||30%|
|dietary fiber 1g||3%|
|total sugar 1g|
|Vitamin C 2 mg||8th %|
|Calcium 44 mg||3%|
|Iron 1 mg||6%|
|Potassium 164 mg||3%|
|*The % Daily Value (DV) indicates how much a nutrient in a food serving contributes to a daily diet. 2,000 calories per day is used for general nutritional advice.|
(Nutritional information is calculated using an ingredient database and should be considered an estimate.)
Eggs are a keto staple because they're high in fat and protein but hardly any carbs. Along with hard-boiled eggs, the main ingredient in egg salad is mayonnaise, which is a perfect keto meal. Mayo has no carbohydrates but offers a significant amount of fat per tablespoon.
We use bacon for a crunchy, salty touch instead of celery and avocado for heavier creaminess and more fat. Our Keto Improved Egg Salad has less than 3 grams of carbs per serving. The recipe is low-carb and gluten-free. It's high in protein and can be used as a vegetarian dish if you omit the optional bacon. Note: If you want to remove the avocado from the egg salad, you can also omit the lemon juice. Its main purpose is to prevent the avocado from browning too quickly and staining the salad.
This quick and easy egg salad will keep for several days when you prep it for meal prep. It's a good appetizer when served with raw foods or keto crackers, and goes well with a keto flax bread or keto almond flour tortilla for a more standard sandwich makeover.
“I love adding avocado to deli salads — tuna, chicken, egg — they all work and benefit from the added flavor, fat, and creaminess. This egg salad might be called “keto,” but I think it's absolutely delicious.” Egg salad that's perfect with some crunchy veggies, whatever your dietary preferences.” – Tracy Wilk
6 hard boiled eggsgrenades removed
1/2 Cup mayonnaise
1/4 Cup mashed avocado
1/4 Cup cooked Bacon chunks, chilled, optional
1 tablespoon yellow or Dijon mustard
1 tablespoon lemon juice
1/2 teaspoon kosher Salt
1/8 teaspoon ground black pepper
Gather the ingredients.
Roughly chop the eggs until the whites are broken into 1/4-inch pieces.
Crack the eggs into a medium mixing bowl, then add the mayonnaise, avocado, bacon (if using), mustard, lemon juice, salt, and pepper.
Gently fold over with a rubber spatula until well combined.
Serve alone or as keto-friendly egg salad wraps. Enjoy!
How to serve keto egg salad
How to make hard boiled eggs
Use this recipe for perfect hard boiled eggs. You can make them ahead of time, or you can boil and peel them at least 15 minutes before you start making the egg salad so the eggs don't dilute the mayonnaise because they're too warm.
How to store it
- Store unused egg salad in a tightly sealed container for 3 to 4 days. If stored for a long time, it can become liquid.
- Egg dishes do not freeze well because they lose consistency. Therefore, we do not recommend freezing this egg salad.
Are Boiled Eggs Carb Free?
A large boiled egg contains 0.6 grams of carbohydrates. That's about half a gram of carbs, so boiled eggs are nearly carb-free. Therefore, boiled eggs are a great choice for the keto diet.


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Lovely 5 BR, 5 Bath sunfilled traditional home in Sag Harbor Village perched on a hill, a quick stroll or bike ride to downtown sag harbor and bay beaches. Central location is 10 minute drive to East Hampton and Bridgehampton. Luxuriate and entertain friends in backyard oasis with heated gunite pool and hot tub (AVAILABLE MEMORIAL DAY TO END OF SEPTEMBER), patio and deck areas. 3800 square foot home on .5 acre boosts 2 floors with an additional large finished lower level. Gracious double height entry leads to spacious, open kitchen with large center island and great room with vaulted ceilings, beautiful skylights, flat screen TV and French doors. In addition, there is a guest bedroom, bath, sitting area, and laundry room. On the second level, there is a master bedroom which overlooks the pool and gardens with ensuite bathroom, 2 guest bedrooms and 2 baths (one ensuite). The basement level boosts a 800 sq. ft. finished space with oversized windows which provide natural light, oversized sectional sofa, flat screen TV/cable, workout room with cardio equipment (elliptical machine, treadmill, recumbent bike), foosball and ping pong table, electronic keyboard, guest bedroom and bath, and young kids’ playroom. Additional features include WIFI/Internet access, driveway with ample parking, whole house filtered water system, multi-zoned heating and air conditioning system.
5 BR/5 bath (sleeps 12) traditional home close to town and bay beaches.
- Calendar last updated:
- Mar 8, 2019
Why Taran Swan chose Sag Harbor
As a native San Francisco Bay Area transplant, I wanted to find some "Bay Area" on the East Coast and found it in Sag Harbor. The charm, beautiful marina and beaches reminded me of home. The friendly people (everyone says hi!) and easy living was a great respite from my hectic life in Manhattan. My weekend and summer home was my escape and the chance for my kids to grow up close to nature like I did. My key criteria was a neighborhood where I could walk to stores and restaurants, parks and beaches. The neighborhood I chose met all the criteria as it was situated near bay beaches and a short walk to town. The home we chose was situated on a small hill on a half-acre plot--a perfect size for a standard pool size and hot tub while allowing for entertainment areas and nice grassy areas for a hammock and room to throw a football. The original home was a "tear down" due to a faulty foundation and low ceiling height in the basement. So we built our dream home--one that was very bright with an open layout, a large kitchen, a great room with cathedral (vaulted) ceilings, and lots of windows/french doors. We also wanted each bedroom to have it's own bathroom, whether en-suite or closeby. That has made a big difference in quality of life for everyone that has stayed at our home. We also wanted a sprawling lower level floor that could serve as a relaxation and fun space. We built a finished basement with non-standard sized windows (5 times the typical) that let in natural light and 8 ft. high ceilings. We added a huge sectional sofa, flat screen TV, gym, electric keyboard, table games (ping pong, foosball), and yes, wall-to-wall carpet for full comfort.
Pool / Spa
Check-in: 4:00 PM
Check-out: 11:00 AM
100% refund if canceled at least 60 days before arrival date.
Long weekend in Sag Harbor
This was the perfect home for my family's stay in Sag Harbor. Great location. Spacious accommodations. Having bedrooms on 3 different levels was really nice, especially since we were traveling with multiple families with young children. Taran was a helpful, accommodating, and responsive host, and her home was the best stocked vacation home I have ever stayed in.
Great space and a great location
This house has so much room! Each bedroom has a bathroom, the kitchen and living area are large and well appointed and the garden with the pool and hot tub were fabulous. The kitchen has everything you need and more. The location is perfect, a short walk to the nearby beach and a longer stroll to town but still very walkable, the street the house is on is very quiet with minimal through traffic. A great place to stay.
Everything was perfect. Really well set up and a very good week and overall experience.
Excellent Owner managed Sag Harbor house!
We've rented houses out east before, mainly Montauk, but this one stood out and I would attribute that to Taran, who is the Owner and Manager of the stay while we were there for a week. Other rentals were always Property Managers we dealt with. It was just professional and pleasant at the same time to work with her. The house was very clean too, which we always appreciate. Very nice back yard and pool/hot tub to enjoy, which we did. And the house is big enough to accommodate a large group, we had our immediate family of 5 for the full week, plus another 8 on/off visitors/family members. A total of 13 of us were actually at the house the same time for two of the nights and the house was big enough to accommodate and keep a large group like that comfortable and happy. I would definitely recommend this house and owner if you are considering a house rental in Sag Harbor. Thank you Taran.
Second home now!
We have spent three weeks for the second time in this great house! A perfect summer at a perfect location! Taran was again an excellent house owner to work with.
And we really enjoyed Sag Harbor again and some new places we discovered this year such as Cedar Point and Elizabeth Morton State Park. The restaurants in town are great and our new favorite place is so close by: Sag Harbor Market and Kitchen. We really recommend the house and the area! Will definitely be back next summer!
Perfect family vacation!
So close to town and beaches, but all you need is already right here on the property. We had such a wonderful time. This was one of the best-stocked vacation rentals we have rented. Coming from the West coast it was nice having access to so many beach supplies/toys/bikes/cooking utensils, etc and not needing to buy a bunch of stuff for our vacation - we felt instantly comfortable and at home here. Thanks for sharing your beautiful home with us! We hope to come back soon!

domain: geography


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The Union Strata snowboard binding is a cross performance wreckingball, featuring a Stage 6 Direct Injected base, that incorporates an “industry first” Fused Vaporlite Bushing System that sets new standards for how a snowboard binding should function and perform. The Strata has quickly become one of Union's most popular freestyle binding models and the reason is clear - Dialed Dampening. Layers of Thermoformed EVA, Duraflex ST Nylon and Fused Vaporlite combine to provide the most vibration canceling ride you've ever experienced. Cruise the park, surf through pow or mash over chunder, the Strata will keep your knees and feet happy all season long.
Disk Type & Compatibility:
Mini Disk fits 4x2, & Channel boards
Stage 6 Base: Duraflex CB Nylon, integrated with super cushioned Non-Stick Coated Vaporlite 3.0 Bushings bring the next generation of Union to the forefront. Union developed a manufacturing process called "Microfused Injection", which focuses the nylon injection entry point around the disk ring where strength is most crucial, resulting in the lightest/ strongest base to date.
Multizone Force Highback is tapered to provide flex and tweakability combined with support and durability where you need it for next level heelside response and board control.
Extruded, Anodized Aluminum heelcup provides a lightweight yet durable design.
Direct connect strap system uses one bolt to connect highback, baseplate, and strap to reduce possibility of hardware loosening.
Forma Ankle Strap: New and improved, the design of the Forma Ankle Strap produces strength and rapid response on the outside, fit and pillowed comfort on the inside.
Dual density injected bushings feature two separate zones to provide supreme dampening and true flex.
Utilizing an injection moulding process very similar to the way plastic parts are created, Fused Vaporlite is a new material that is more waterproof, durable, and precise than any other EVA material on the market today.

domain: design


text:
Standing Up to POTS was founded in 2014 and is a 501(c)(3) non-profit organization and works to improve the quality of life for people living with postural orthostatic tachycardia syndrome (POTS) through research, advocacy, and support. Because we are run completely by volunteers, 95.3¢ of every $1 received from all sources is spent on innovative POTS research (86.6¢) that aims to improve the quality of life for people currently living with POTS or advocacy efforts including The POTScast (8.7¢).
Standing Up to POTS was founded by Dr. Cathy Pederson in 2014 after her daughter was diagnosed with POTS. Standing Up to POTS was created to generate a community who can support each other while pushing forward understanding of POTS. Dr. Pederson earned her Ph.D. in Physiology and Neurobiology from Rutgers in 1996, and has dedicated all of her professional research efforts to POTS, chronic illness, and quality of life since her daughter's illness.
Although postural orthostatic tachycardia syndrome (POTS) is not visible or typically life-threatening, it causes an enormous emotional, physical, and financial burden to POTS patients and their families. The burden to POTS patients is made worse by the lack of understanding and awareness by most people, combined with some of the unique features of POTS, such as inability to be upright, frequent fainting episodes, adrenaline rushes, severe brain fog, pain, and the unpredictable flares of these symptoms. The high degree of physical disability, cognitive impairment, pain, and disruption to schooling/career/life plans leaves these patients with myriad challenges to everyday living. They often struggle with finances, relationships, daily chores, grooming, maintaining proper nutrition and weight, communicating their needs to family and friends, finding supportive social circles, finding social activities that work for them, and maintaining good mental health.


When Dan Shideler first saw the Smith & Wesson Model 317 AirLite .22 Snubbie, his reaction was, "You gotta be kidding."
Obviously, there could be no practical use for a BB gun that used a .22 blank cartridge as a propellant; which meant, of course, Dan Shideler just had to have one.
Is the AR-15 somehow beyond the pale of legitimate, serious gun collecting? I used to think so, but I've changed my mind. Let's examine why some otherwise well-balanced gun collectors don't pursue the AR-15.
Colt's Police Positive languishes in the shadow of its prettier offspring. But the collectibility of those descendants prove what a sound design the original was.
Dan Shideler is a Marlin .22 man, and the model that tickles him the most is the original 70P Papoose Take-Down Rifle.
My favorite snubnose revolver? The Colt Pocket Positive, manufactured from 1905 to 1940. It has one critical attribute that characterizes so many Colt revolvers: Style.
Of all the Hand Ejectors Smith & Wesson ever made, the finest and most well-mannered was the .38 Outdoorsman.


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In the first half of this year, the implementation of the agricultural mechanization policy and the organization of agricultural mechanization production were effective, orderly and effective. The key tasks such as technology promotion, education and training, supervision and management were steadily advanced, and the countryâ€™s agricultural mechanization maintained a sound and rapid and healthy development.
Standardized, efficient and honest implementation of agricultural machinery purchase subsidies policy, the total growth of agricultural machinery and equipment. By the end of June this year, the central government had implemented a total of 11.28 billion yuan in subsidy for agricultural machinery and machinery purchases, accounting for 82% of the first batch of subsidy funds of the central government, and benefiting 2.497 million peasant households. The number of agricultural machinery and equipment used in key crops and key sectors increased rapidly, and the number of large and medium-sized tractors and supporting agricultural tools increased by 12.4% and 12.3% year-on-year respectively. The agricultural machinery industry is booming in both production and sales. The production and sales ratio is over 96%.
Efforts were made to organize spring plowing and the "three summers" of agricultural mechanized production, and the area of â€‹â€‹agricultural machinery operations continued to increase. A total of 23.6 million agricultural machinery were put into operation in the country for spring cultivation, sowing, and irrigation. A total of 650 million mu of machinery were cultivated in spring and 530 million mu were broadcasted on machines, an increase of 10 million mu and 20 million mu respectively over the previous year. This year, the country's â€œthree summersâ€ large-scale wheat harvested across regions, completed a machine harvest area of â€‹â€‹282 million mu, machine harvesting level of nearly 90%, and a new high. The cross-regional operation of agricultural machinery has many input devices, rapid wheat harvest progress, good market order, and low expenditure.
Vigorously carry out scientific and technological innovation and promotion of agricultural mechanization, agricultural machinery and agronomy further integration. Launched national agricultural machinery science and technology innovation and promotion actions, carried out research and demonstration of key technologies for the integration of agricultural machinery and agronomy of major crops, increased the promotion of 18 agricultural machinery and other key technologies for deep soil preparation, and formulated and issued guidance opinions on the mechanization of potato and rapeseed production. Continued implementation of agricultural mechanization education and training. In the first half of the year, China trained a total of 2.6 million agricultural operator operations, improved conservation tillage, spring corn (wheat) planting mechanization, suppression and conservation techniques, rice transplanting and mechanization techniques, and mechanization of field management in the spring. Technology and other new technology applications.
Strengthen the supervision and management of agricultural machinery, agricultural machinery safety production situation remained stable. Established a comprehensive agricultural, provincial, city, and county agricultural machinery quality complaints and supervision network, focused on the implementation of the special action of "non-compliance and violation of laws and regulations" in agricultural machinery safety production, and organized the supervision of agricultural machinery safety, "promoting excellence in service for the people" demonstration model and demonstration positions model Create an activity. The responsibility system for agricultural machinery safety was implemented throughout the country and efforts were made to eliminate potential accidents. The situation of safe production of the â€œthree-summerâ€ agricultural machinery remained stable during the first half of the year. There was no major agricultural safety accident in the country in the first half of the year.
Solar Cell Panel
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domain: agronomy


text:
Matsui, pride of the Yankees
Fans fly out to see a “sayonara” hit
THE possibility, however remote, of getting SARS will deter many Japanese from going abroad for their Golden Week holidays, which last roughly from April 26th until May 5th. But baseball supporters are a breed apart. It will take more than a virus to stop them making a trip to see the Japanese stars in action in America's major leagues. The most popular excursion for the Japanese visitors will include a three-game showdown in New York featuring Japan's Hideki Matsui of the Yankees, and a handful of Japanese stars who play for the Seattle Mariners.
The best-known Mariner, Ichiro Suzuki, left Japan's baseball league to join Seattle in 2001. Many Japanese supporters were crushed when Seattle was knocked out of the preliminary games for the World Series that year. Now the wiry Mr Suzuki has been eclipsed by the power-hitting Mr Matsui, once a star with the Yomiuri Giants and now with America's most famous baseball team. On April 8th, he hit a “grand slam” (a home run with the bases full) in his first game at Yankee Stadium. A few nights later he delivered his first “sayonara” hit, a game-winning run.
Traditionally, the Japanese have rated teamwork above the skill of the individual. But with the success of Japanese baseball players in the United States, and of their soccer players in Europe, sports fans are now more interested in the adventures of players overseas than they are in the progress of teams at home. The evening television news provides a rundown of how Japanese players are performing in their latest games, giving particular attention to the mighty slugger Matsui. Most newspapers publish statistical tables that show how Japanese players are doing in America. The Asahi Shimbun has revamped its sports section to highlight Mr Matsui's doings.
With many local economies in the United States flagging, towns might consider inviting an entire Japanese baseball club to fly out to play American baseball. Japanese fans would no doubt cross the Pacific in droves all summer long to support their club. They would probably fly on Japanese airlines, but think of all the shopping they would do in America.
This article appeared in the Asia section of the print edition under the headline "Matsui, pride of the Yankees"
From the April 26th 2003 edition
Discover stories from this section and more in the list of contentsExplore the edition
Japan’s prime minister has seen his popularity plummet in the past two months
Yet achieving its goal of becoming a rich country by 2045 will still be a huge task
Russia is upsetting friends and losing influence in Asia


text:
Traditional in design and modest in scale, the elegant Mayville Collection takes its design inspiration from the classic Louis Philippe styling. Featuring four distinct finishes – burnished brown cherry, white, black, and the newly offered stained grey – with all of the traditional flare unique to the style – antiqued metal bale hardware and distinct framing – this collection is a perfect addition to your traditional adult or youth bedroom.
From the time order is placed, Sleep Center will contact you within 2 Business hours to confirm delivery day and time window.
Mattresses that are in stock will be delivered same day or next day.
Mattresses that are not in stock may take 4-8 business days for the delivery of your mattress.
The delivery team will bring in the mattress and place your new mattress into your bedroom, unpack it and take away the packaging for you.
Removal of your old mattress set is included. You must notify the delivery personnel at the time of delivery of the mattress set.


Product ID: CDP2MDP
This USB Type-C to Mini DisplayPort adapter lets you output mini DisplayPort (mDP) video and audio from the USB Type-C port on your laptop or other device. It works with USB 3.1 or Thunderbolt 3 Type-C devices that pass an mDP video signal, such as your MacBook Pro, Chromebook or 2018 iPad Pro.
Harness the video capabilities that are built into your computer's USB-C connection, using the adapter to deliver the astonishing quality of UHD to your 4K 60Hz display.
You can achieve an output resolution of up to 3840 x 2160p at 60Hz, perfect for high-resolution tasks such as viewing 4K video. The USB-C video adapter is backward compatible with 1080p monitors or displays, which makes it a great accessory for workspace applications.
This adapter lets you use the versatile USB Type-C port on your portable device. USB-C is a reversible connector, enabling you to plug it into your device in any direction. The Thunderbolt 3 compatible adapter provides a hassle-free connection to your Windows or Mac based Thunderbolt 3 computer.
The compact USB-C to mDP adapter is lightweight and fits perfectly in your laptop bag. Its portable design is ideal for BYOD (Bring Your Own Device) applications at the office or on the road.
The CDP2MDP is backed by a 3-year StarTech.com warranty and free lifetime technical support.
Your USB-C device must support DisplayPort over USB-C (DP Alt Mode) to work with this adapter
This adapter outputs a single-mode Mini DisplayPort signal and will not work with additional video adapters such as Mini DisplayPort to HDMI, Mini DisplayPort to VGA or Mini DisplayPort to DVI adapters
|Warranty Information||Warranty||3 Years|
|Connector(s)||Connector A||1 - USB-C (24 pin) DisplayPort Alt Mode|
|1 - Mini-DisplayPort (20 pin)|
|Environmental||Operating Temperature||0°C to 45°C (32°F to 113°F)|
|Storage Temperature||-10°C to 70°C (14°F to 158°F)|
|Hardware||Active or Passive Adapter||Passive|
|AV Output||Mini DisplayPort - 1.2|
|Chipset ID||NXP - PTN5100
Pericom - PI3DPX1203
|Packaging Information||Shipping (Package) Weight||0.1 lb [0.0 kg]|
|Package Length||8.9 in [22.5 cm]|
|Package Width||4.9 in [12.5 cm]|
|Package Height||0.0 in [0.07 mm]|
|Performance||Audio Specifications||DisplayPort - 7.1 Channel Audio|
|Maximum Cable Distance To Display||2000|
|Video Revision||DisplayPort 1.2|
|Maximum Digital Resolutions||4K (3840 x 2160) @ 60 Hz|
|Supported Resolutions||1024 x 768
1280 x 720
1920 x 1080 @ 144hz
1920 x 1200
2560 x 1440
2560 x 1600
3840 x 2160 @ 60Hz
|Wide Screen Supported||Yes|
|Cable Length||0.6 in [14 mm]|
|Product Length||7.1 in [18 cm]|
|Product Width||1.1 in [26.98 mm]|
|Product Height||0.6 in [1.6 cm]|
|Weight of Product||0.8 oz [23 g]|
|Special Notes / Requirements||System and Cable Requirements||Your USB-C device must support DisplayPort over USB-C (DP alt mode) to work with this adapter|
|This adapter outputs a single-mode Mini DisplayPort signal and will not work with additional video adapters such as Mini DisplayPort to HDMI, Mini DisplayPort to VGA or Mini DisplayPort to DVI adapters|
|This adapter will not support Thunderbolt displays|
|What's in the Box||Included in Package||1 - USB-C to Mini DisplayPort adapter|
Connect your Mini-DisplayPort-equipped computer to a standard DisplayPort monitor
Create a high-resolution 4k x 2k connection with HBR2 support between your Mini DisplayPort™-equipped laptop and monitor
To arrange extended displays on Windows 10, complete the following.
To arrange extended displays on macOS, complete the following.
Check out our review guidelines.


Estimated read time: 2-3 minutes
This archived news story is available only for your personal, non-commercial use. Information in the story may be outdated or superseded by additional information. Reading or replaying the story in its archived form does not constitute a republication of the story.
Courtney Orton reporting The Junior National Figure Skating competition is in town, and skaters from around the country are competing to be known as the best in the United States.
One skater is from Salt Lake: 11-year-old Angela Wang, who has a very good chance of taking the title.
Angela started skating when she was very young. Today, it seems to have paid off because she not only qualified to move on but she placed first, way ahead of everyone else.
Angela's reaction to her score speaks for itself, and so does her execution of each part of her program. "It's just awesome! It's an awesome feeling to do it in my hometown and just in front of everyone I know," she said.
She knew a lot of people in the audience today. That's because her sixth-grade class skipped school to cheer her on. They watched intensely as she nailed each jump and hit every bit of footwork.
"At the first of the year I asked the kids to think about doing their personal best, and what more could Angela do this year than skate like she did today," Angela's teacher, Patti White, said.
"It just gave me a lot of energy to do what I could do and show them my best," Angela said.
They even displayed a sign. Then when her program came to an end, they littered the rink with stuffed animals.
Angela's hard work had paid off. She ended up five points ahead of everyone else who qualified. "This is a child who trains hard. She trains smart and she has a smart coach," Shannon Michael, of the Salt Lake Figure Skating Club, said.
Angela's coach, Lisa Kriley, said, "It's a team effort. It's definitely a team effort to get an athlete to that level at this age."
A boost of confidence to rock the rink tomorrow, the day after, and maybe even after that. "Yeah, I really want to go to the Olympics because I love skating and I love skating in front of a crowd. I just hope to be one of the best," Angela said.
Angela will skate again tomorrow and Saturday.
She's not the only one from Salt Lake who is competing. There are six other local skaters hoping to qualify today as well.


Updated September 14
The Steamship Authority ferry Island Home went out of service Thursday and departed for the ferry line’s Fairhaven facility for engine work. SSA spokesman Sean Driscoll said the engine of the Island Home will undergo a turbocharger replacement. Driscoll said the ferry is expected to be out of service for a week, and the Martha’s Vineyard will be taking over the vessel’s trips. On Tuesday, five days after Driscoll spoke about the vessel, SSA director Mark Amundsen said the vessel would be sidelined for a bit longer— “approximately six or seven days.”
As part of planned maintenance, the SSA is replacing “the turbocharger on the main engine.”
Amundsen went on to say, “The supply chain has been very difficult over the past year.” To that point, Amundsen said, turbos ordered a year ago didn’t arrive in time for overhaul periods slated earlier in the year.
Amundsen said the Island Home was due for maintenance anyway, and his team didn’t want to wait until January to do the turbo work, so the choice was made to begin work on the ferry last week.