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Nikon has just joined to other companies and individuals who are offering free education during the coronavirus pandemic. During the entire April, everyone will have free access to all videos in Nikon School.
If you’re a Nikon shooter based in the USA or Canada and your gear goes down over the next few weeks, you’re going to have a wait on your hands to get it back up and running – not that most of us will have jobs to go shoot anyway. Nikon USA has announced that it has closed down its camera repair service and are currently not accepting equipment.
This follows an announcement a few days ago that Nikon Canada had also suspended their repair service as well as Nikon Pro Services (NPS) loaners. Nikon Australia has also closed its Sydney Office and their Service Centre, although they are still accepting deliveries by courier only.
Well, this is interesting. According to the latest report from BCNRetail, Olympus has ousted Nikon, Canon, Sony and Fuji to top the sales in Japan for the month of February, thanks to pretty significant sales of the Olympus PEN E-PL9, taking 11.1% of the share and the OM-D E-M10 Mark III grabbing a further 5.2%.
The graph above shows mirrorless sales share in Japan by total number of units sold. Amongst the top ten camera spots, Sony claimed four of them, with Canon taking a further two, and Nikon & Fuji taking one each.
Nikon might have taken their sweet time to follow Sony onto the mirrorless bandwagon, but they seem to be catching up somewhat in features. They’ve just announced new Version 3.00 firmware for the Nikon Z6 & Nikon Z7 mirrorless cameras which adds animal detection to the Eye-AF feature. They’ve also released Version 1.10 for the Nikon Z50 to address a couple of things.
The Nikon D6, Nikon’s newest flagship DSLR, has now officially been announced. While not all of the rumours were true, it’s an impressive looking camera. It has a brand new 105-point all cross-type autofocus system, ISO from 100 to an impressive 102400, built-in GPS, WiFi, Bluetooth and Gigabit Ethernet, dual CFexpress slots, and more.
One of the most notable features, however, is that it appears to have some form of Eye AF implementation when shooting in regular optical mode through the viewfinder. Nikon says that “the D6 is the first DSLR to let you prioritise focusing on your subject’s eyes when using Auto-Area AF or 3D tracking”.
Even though there’s been no official announcement on the specs for the Nikon D6 (it’s expected at some point this month), Digital Camera World reports that the Nikon D6 will be on show in the UK during The Photography Show taking place on the 14-17th March at the Birmingham NEC in England.
They say that Nikon has announced this, but I haven’t been able to find a press release. But DCW is owned by Future Plc., which is the same company that runs The Photography Show. So, if anybody would know if this was true or not, it’s them!
The competition is fierce among smartphone brands. The camera and camera features are now a critical aspect in phone marketing. More megapixels, more cameras, and better software are key features when it comes to market strategies.
R&D is expensive so establishing partnerships with other manufacturers makes sense twice: Firstly, it saves on development resources. Secondly, it validates the brand and puts a prestigious halo around it. Just look at the last crop of partnerships: Huawei & Leica, Motorola & Hasselblad and Nokia & Zeiss. (I could possibly say Sony & Sony, but that would just be funny). Now Xiaomi wants in on the camera “old money” and seeking out a partnership.
Seeing lenses taken apart and dismantled for the first time, or anything mechanically or electronically complex just fascinates me. I don’t know what it is about it, because it’s unlikely I’ll ever need to take one apart myself, and it serves no real educational or practical benefit. But I just find it interesting to see what makes this stuff tick.
One I’ve been particularly seeing inside is the new Nikon Z 24-70mm f/2.8 S lens, and as usual, Lens Rentals has not let us down. They’ve just posted a teardown of the Nikon Z 24-70mm f/2.8 S lens to their blog, and it shows that Nikon really seems to have stepped up their game when it comes to design and engineering.
Many of us have experienced a memory card failure at some point, and although manufacturers have gotten much better at producing reliable cards, it still occasionally happens. Failure used to be fairly common in the early days of CompactFlash (when their capacity was still measured in MB) and in SD cards, but it’s rare that you hear about it in modern formats like XQD. It does happen, though.
I’ve been following HDD Recovery Services on YouTube for a little while now. I just find it fascinating to see how hard drives and other storage mediums work on the inside, and how they evolve over time. Recently, they received a Sony XQD card that wasn’t reading, and the client needed the data recovered from it. This video shows us what’s inside, and how they get it working again.


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It’s the 8th of the month –Blog Hop time from Reverse Confetti! The hop started over on the Reverse Confetti blog, and you should have made it here from Sarah Gough’s blog. It would be worth your while to start at the beginning of the hop, so you don’t miss a thing. We have tons of inspiration for you to see using all of Reverse Confetti’s amazing stamp sets!
To create my card, I started with a turquoise card base, and added a strip of dark gray floral patterned paper. I then stamped one of the stripe images from So Stripey in yellow ink onto white cardstock before adhering it to the card front.
Next, I stamped one of the sentiments from Lots to Say, as well as the banner image from Happy Harbor, in versamark ink before embossing with white powder. Once that cooled, I then stamped one of the polka dot images from Whole Lotta Dots onto the gray panel, and heat embossed with clear powder. To finish up, I added some turquoise twine and embellished with some enamel dots.
I hope you’ve enjoyed hopping with us today. Be sure and hop with us on the 8th of EVERY MONTH for more Reverse Confetti inspiration! Now it’s time to hop on over to Julia Stainton’s blog. If you get lost along the way, you can find the hop order and list of all the participating designers over on the Reverse Confetti blog.
How would you like to win some Reverse Confetti goodies of your very own? Leave a comment on each stop along the way for a chance to win a $15 gift certificate to Reverse Confetti. Comments are open until Monday, December 9th at 2pm CST, and the winner will be announced on the “Time for a Card Tuesday” post over on the Reverse Confetti Blog!
A couple things before you hop along though, just to keep you “in the know”…
- December’s SKETCH FOR YOU TO TRY is open for you to play along. Click HERE for a chance to win.
- Be on the lookout for our second COLOR challenge we will be introducing on December 16th and another way to win!
Have a great one!
Stamps - Whole Lotta Dots, So Stripey, Lots to Say, Happy Harbor (Reverse Confetti)
Paper - Hawaiian Shores, Soft Stone, Stamper's Select White (PTI); Floral Patterned Paper (Echo Park)
Ink - Yellow Memento Luxe, Versamark
Miscellaneous - White Embossing Powder, Clear Embossing Powder (Hero Arts), Twine (The Twinery)

domain: hobby


Portcoast Digital Transformation Center specializes in providing surveying services to collect topographic data by UAV/Drone unmanned aerial vehicle. With LiDAR technology on the drone has simplified the whole surveying process, safer and cost-effective.
We apply this solution for topographical survey of land, buildings, construction sites, quarries, mines and highways, etc.
STORMBEE is a user-friendly Unmanned Aerial Vehicle (UAV) custom designed for lasers canning with a FARO Focus laser scanner.
This is one of the most advanced drones. Equipping sensors in multiple directions gives the Matrice 300RTK outstanding safety. The Matrice 300RTK - Zenmuse L1 system is capable of capturing image and point cloud data, based on 3 times response signal from the Lidar and penetrating through the foliage…
PPSDK 102S V3, the 5-lens oblique camera with 3-Axis Stabilized Gimbal, is a highly integrated surveying camera specialized in aerial photogrammetry. Full-on efficiency booster brings unprecedented operating experience. The adjustable parameter allows camera applicated in various scenarios. Also widely compatible with open-source payloads.
TThe Matrice 30T model drone is one of two devices in the new matrice 30 series that DJI launched in March. It is an extremely useful tool for many industries. Their thermal imaging and camera capabilities allow them to perform inspections in the energy industry quickly and efficiently.
Phantom 4 RTK is an unmanned aerial vehicle with built-in topographic surveying capabilities, 2-frequency GPS receiver, combined with a base station… It is highly effective in tasks: flying and capturing topographic maps. main, topographic map flight, electric route capture flight, or real-time RTK dynamic measurement, PPK GPS post-processing dynamic measurement…
Address: 328 Nguyen Trong Tuyen Str., Ward 2, Tan Binh Dist., Ho Chi Minh City
Phone: (84 - 28) 62970345; 62970341


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Just Around The Corner
Fast Food, Burgers
76 Ted Turner Dr NW (at Marietta St NW)
Atlanta, GA 30303
- You have to try the salmon burger. This thing is delicious!
- Good grilled cheese and cucumber salad
- Burgers. Salmon burgers. Yum l
- The fish basket off the hook and so is their burgers
- good food at a great price! and quick! burger, fries, and a drink for $7 in downtown Atlanta? I'm in. Plus some of the most underrated wings in the city, 20 wings for $13.99, beat that!
- Ham and cheese (you'll thank me LOL)
- I love the fish sandwich here!
- The Bird and Basic Cheesestake are absolutely the best!
- The burger is okay, but the 'satchmo' always hits the spot...
- Get the "Basic Cheesesteaks".

domain: food


In Washington, there is no higher art form than the non-denial denial, in which politicians try to rebut a storyline without quite denying the specifics.
That is what is underway now with Bob Woodward’s latest book, “State of Denial,” an unflattering portrait of an administration riven by discord over the Iraq war.
Mr. Woodward’s narrative is unsurprising to anyone who has closely followed the Bush administration: the first-term loyalty of aides devolved into infighting as soon as no weapons of mass destruction were found in Iraq. Then the intramural squabbling turned into public protestations of “if-only-they-had-listened-to-me.”
For its part, the White House did deny that Secretary of State Condoleezza Rice and Secretary of Defense Donald H. Rumsfeld have a private war of their own underway. But what about another disclosure that Andrew H. Card, the former White House chief of staff, twice suggested booting Mr. Rumsfeld? Mr. Card, in an interview, acknowledged the recommendation but said it came in the context of broader discussions of cabinet changes.
And what about the officials in the Bush administration who were ignored when they called for an increase in the number of troops in Iraq? Among them were Robert D. Blackwill, the Iraq coordinator at the White House, and L. Paul Bremer III, the senior American overseeing the Iraq occupation. But none, said Tony Snow, the press secretary, were in the “chain of command,” meaning that they were not generals asking for more troops.
Did Mr. Bush listen only to his generals? Of course not, said the White House.
So what happened to all those recommendations? No one is willing to say.Continue reading the main story


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October 30th, 2019
The following is a press release issued by Boulder Amplifiers.
October 30, 2019 | Louisville, CO – is pleased to announce the immediate release and shipment of the 866 Integrated. The 866 is a part of the 800 Series and the successor to the highly successful 865 Integrated Amplifier.
The 866 will be released in two versions: an all-analog version ($12,250) and an analog+digital ($14,450) version.
Features of the all-analog version will include:
Features of the analog+digital version will include:
The 866 Integrated is the successor to the 865 Integrated Amplifier and Boulder’s first integrated amplifier to feature the option of digital inputs. A premium was placed on value in the 866 and greater effort was put into the efficiency and cost reduction of design and manufacturing than any previous product from Boulder. Cost savings include circuit board production (up to a 25% reduction for some boards), casework and power supply cost reductions, reduced loading and turns for metalwork machining, material efficiency, and the reduction of production and testing time. More than twelve years after the release of the original 865, this has enabled Boulder to price the all-analog 866 at $12,250 with 200W of power output, whereas the 865 was priced at $14,000 and had power output of only 150W. The analog+digital 866 also includes full digital capabilities and greater power output but costs only $450 more than the 865.

domain: news


People gather at the explosion site in Mogadishu, capital of Somalia, on Aug. 30, 2016. At least seven people were killed and several others injured in a bomb explosion that hit a popular hotel in Mogadishu on Tuesday, police have confirmed. (Xinhua/Faisal Isse)
MOGADISHU, Aug. 30 (Xinhua) -- At least seven people were killed and several others injured in a bomb explosion that hit a popular hotel in Mogadishu on Tuesday, police have confirmed.
Two journalists from a local television station alongside lawmakers were among those injured in the deadly explosion at SYL Hotel near the presidential palace in the Somali capital.
Mahad Farah, a police officer at the scene, told Xinhua that the explosion happened a few meters from the SYL Hotel entrance when security guards fired at the car which they suspected was about to launch an attack.
"We have established the death of seven people and several others injured. The security guards fired at the car then it immediately exploded," said Farah.
The hotel, which came under similar attack in February this year, is frequently by senior government officials and diplomats.
The explosion ripped apart a section of the hotel. A security meeting was under way at the hotel.
Eye witnesses said the explosion was very powerful and shook buildings around.
"The whole place shook and then there was heavy gunfire. I could see many people lying on the ground injured and some dead," said Ahmed Yasin, a driver.
Somalia-based Al-Shabaab terror group, which repeatedly staged similar attacks on government buildings and officials, has claimed responsibility for the attack.


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War Commander takes place in the future where savagery has replaced civilization. Command, attack, and defense bases with your units!
The War Commander is every part of this wiki is very incomplete and incorrect . Help improve this wiki by adding content to it!
The practically complete wikia of War Commander can be found here: Unofficial War Commander Wikia
warcommander is rubbish and should not be a game
Kixeye don't listen and make it hard for lower levels
Please show patience with any development issues during their special events... There are heartfelt apologies within the forums from the developers.

domain: game


Pillow Block Mount, ea
This is a bracket that will let you bolt a sway bar pillow block to the side of your frame rail. Great for when you need to mount the sway bar directly under the rail to save space. You could also notch the bottom of the rail to recess the sway bar slightly.
Laser cut from pickled & oiled 3/16" mild steel. Holes are for 3/8" bolts (not included).
Bend the bracket and built-in gussets with an adjustable wrench along the laser cut slits, then mig weld them.
Fits Energy Suspension pillow blocks (not included).


‘The cabinet of broken Republican dreams’: Stephen Colbert eviscerates Trump’s healthcare failure Stephen Colbert on Tuesday issued a brutal takedown of Donald Trump’s failure to push through a plan repeal and replace Obamacare, noting that despite the... Raw Story 5 hours ago - US Also reported by • Mashable • Gothamist
Even Some GOP Governors Hate Donald Trump's Budget WASHINGTON ― President Donald Trump’s standard-Republican, program-slashing proposed budget has found some critics in seemingly unlikely places:... Huffington Post 6 days ago - Politics
John Oliver Tries To Make Sense Of 'Toddler Psychopath' Donald Trump's Budget John Oliver is trying to figure out how President Donald Trump’s staff came up with the widely criticized budget proposal released last week.
He found a... Huffington Post 1 week ago - Politics Elmo From 'Sesame Street' Learns He's Fired Because Of Donald Trump's Budget Cuts Elmo... laid off???
A new parody video from What’s Trending shows what could happen if President Donald Trump’s proposed budget... Huffington Post 1 week ago - Politics
John Oliver nails it: ‘Consistently monstrous’ Trump is cutting non-military programs as a ‘f*ck you’ President Donald Trump’s budget was crafted from his speeches, Office of Management and Budget Director Mick Mulvaney told “CBS This Morning.” But when... Raw Story 1 week ago - US Is Trump gutting Meals on Wheels? His budget director says no. Meals on Wheels, the popular nationwide program that provides hot meals to needy seniors, has become a rallying point for critics of President Donald Trump's... Denver Post 1 week ago - US
Stephen Colbert Slams Donald Trump’s ‘Bureau of Obvious Nepotism’ Stephen Colbert ripped President Donald Trump for hiring his own son-in-law for a key job in a newly created department.
Jared Kushner, who is married to... Huffington Post 34 minutes ago - Politics Colbert resurrects ‘Colbert Report’ character to skewer Trump’s ‘cruel to old people’ budget cuts A familiar conservative pundit joined Stephen Colbert on Monday’s episode of “The Late Show with Stephen Colbert” to explain why Donald Trump’s 2018... Raw Story 1 week ago - US


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Yonkers police investigate 2 bank robberies
Here are five things you need to know about crime in Westchester County. Video by Jordan Fenster/lohud Wochit
Yonkers police are investigating two bank robberies on Yonkers Avenue late Thursday afternoon.
The two banks, Tompkins Mahopac Bank and HSBC, are across the street from each other.
In both incidents, the suspect passed a note to the teller demanding money. No force or weapon was used, police said.
Because the investigation is ongoing and a manhunt is underway for the suspect, police didn't release any other details.

domain: law


- Bensenville, IL, USA
- No price
- STILL heat exchangers
Interested in this machine?
45288099 Used- Finn Aqua WFI Still, Model 200-H-1. Single effect with heat exchanger, rated 116 psi at 347 f shell and tube sides, with controls, serial# 34973.
Get email updates for STILL 200-H-1


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Smelly, moldy, old food in the parking area strewn about, reception area looked like someone's hundred year old smelly living room, photos on the internet are totally misleading. Threadbare linens, ancient furniture and t.v., lampshade hanging by a thread, I have never seen a hotel room as bad as this. Spent one night and got the heck out of there. Felt deceived by the photos on the internet.
- Official Description (provided by the hotel):
- Waimea Country Lodge is a rustic 21-room lodge located in historic Waimea Ton, the center of Paniolo (Hawaii cowboy) country. Amid cool air and rolling grasslands, the lodge offers spacious rooms, studios with kitchenettes and a friendly "down home" atmosphere. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Expedia, Hotels.com, Hotwire, Travelocity, Priceline, Cheap Tickets, getaroom.com and HotelQuickly so you can book your Castle Waimea Country Lodge reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Waimea Country Hotel Waimea

domain: travel


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In November 2022, INE estimates that the active population (5,198,400) decreased, compared to the previous month, by 1,800 people.
Portugal’s unemployment rate rose to 6.4% in November, its highest level since July 2021 and up from 6.0% in October and 6.2% in November of 2021, according to provisional data released on Friday by the National Statistics Institute (INE).
“The unemployed population (331.6 thousand) increased from the three periods under comparison (previous month, three months before and same month of previous year): 5.9%, 6.7% and 3.2%, respectively,” reads the English version of the INE’s Monthly Employment and Unemployment Estimates. “The unemployment rate stood at 6.4%, also up from October and August 2022 (0.4 pp from both months) and from November 2021 (0.2 pp).”
In November 2022, INE estimates that the active population (5,198,400) decreased, compared to the previous month, by 1,800 people (a relative variation of almost zero) and that it increased by 0.5% compared to November 2021.
Final data for November is expected to be released in about a month’s time, along with the provisional figures for December; Friday’s release contained the final data for October.
“The unemployed population (313.2 thousand) decreased by 0.6% from September 2022 and by 4.1% from October 2021, having increased by 3.1% from July 2022,” reads the release. “The unemployment rate stood at 6.0%, down 0.1 percentage points (pp) from the previous month, up 0.1 pp from three months before and down 0.3 pp from a year earlier.”


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Morning Parade, ‘Marble Attic’ (Live at Heaven) – Exclusive Video
Formed in 2007, British alt-rock quintet Morning Parade holed up in an Essex studio to focus on writing songs before finally making their first public appearance back in 2010. Their self-titled debut album dropped in March, and was recently followed up with 'SE1 Live Session,' a six-track live EP recorded last year at the London venue Heaven and released exclusively via iTunes.
Five of the tracks on the EP were also featured on Morning Parade's full-length debut, but 'Marble Attic' -- one of the first demos ever recorded by the band, and the tune performed in the exclusive video seen here -- didn't make the cut. "We opened the show at Heaven with it," guitarist Chad Thomas tells Diffuser.fm of the tune. "It was very difficult for us to leave it off the album, but it's one of our favorite tracks to play live. We like to surprise the audience with it every now and again. It's a raucous rock/dance behemoth. Great tune to break the ice with the crowd."
Morning Parade recently kicked off a two-month North American tour featuring dates with both Civil Twilight and fellow British rockers the Wombats that will keep them on the road through an Oct. 17 gig in Boston, Mass. Check out the trek's complete itinerary here after watching the live 'Marble Attic' clip, and get the band's album on iTunes.

domain: entertainment


History and Heritage
Building on nearly 200 years of engineering excellence rooted in Norway, Aker Solutions has grown into a global oil-services company that creates some of the most innovative technology in the industry. Its oil and gas projects range from underwater installations the size of football fields to equipment that works in the deepest waters and most challenging environments. Aker Solutions in 2014 streamlined its business to focus on two main segments, subsea and field design. Today it employs about 16,000 people in some 20 countries, spread through Africa, the Americas, Asia Pacific and Europe.
IP-Group and Aker Solutions' project department have, through close and good cooperation, designed an Aluminum pallet with special friction for Oil Platform in the North Sea. Special friction is applied to the top deck as well as under the runners to have a stable and good storage on oil platforms. Our long experience and flexible production process are our strengths in Aluminum design. We tailormade special individual solutions and concepts to our customers' need. We are proud that Aker Solution and Equinor chose IP-Group as a partner.
-Geir Vidar Persen, Sales Director IP-Group


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Online dating may be convenient, nonetheless it is also high-risk. Dating sites will be vulnerable to internet threats, including viruses and malware. Quite a few people may even end up being unaware of how you can protect themselves.
A study by Kaspersky Lab, a cybersecurity business, investigated the online dating practices of 21 years old, 081 users aged fourth there’s 16 to sixty four in 32 countries. Their answers reveal that a number of users are concerned about viruses, scammers and malicious backlinks.
According to the study, persons just who date web based are more prone to THAT security concerns than those who have do not. Actually the majority of over the internet daters have noticed some form of trouble or threat. Particularly, 55% have had to deal with problems. This includes being rejected by potential matches and IT secureness incidents. Among the issues, people are most worried about poor intentions.
A large part of people who time online use pcs, tablets or perhaps phones. Utilizing a device with regards to online dating places confidential company data at risk. https://eurobridefinder.com/do-russian-women-like-american-men That is why many people are concerned https://www.fiverr.com/gigs/dating-tips about malware and scammers. One in twelve online daters are concerned about harmful links.
Most people match their partners offline, though many are turning to seeing apps. One third of via the internet daters limit the volume of information that they share with their periods. Another 9% have had discussions that they found unpleasant.
A large number of people who how to use online dating site have experienced an awkward first of all date. Just about everyone has used a web based dating internet site. However , one out of five singles have been in a fully commited relationship with somebody they realized on a internet dating site.


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Elmina was the daughter of Julia Ann (Woodmansee) and Gordon Cloyd of Darke County. She grew up in German Township, but moved to Richmond in her early 30s where she was employed in a "domestic" setting.
Elmina and Samuel Garrison (1864-1949) were married September 13, 1896 in Darke County by minister O.D. Becker. Their son was Elvin Waldo Garrison (1898-1986). The family lived in Richmond and eventually moved back to Darke County, Harrison Township where Elmina passed away.

domain: geography


text:
The Sorting Hat describes Gryffindor in Harry Potter and the Sorcerer’s Stone as the house “where dwell the brave at heart, their daring, nerve, and chivalry set Gryffindors apart.” These qualities are the ones that show how Gryffindors will truly appreciate science fiction novels. After all, since they appreciate adventure, so there are so many sci-fi books Gryffindors will love.
Sci-fi often deals with other worlds and grand adventures, so it makes sense that daring and brave Gryffindors would be drawn to these stories. Of the many sci-fi stories out there, it may be difficult for Gryffindors to choose which one to read next. Once you’ve gone through classics such as the epic Dune or the ever-popular Ender’s Game, what do you read next? Obviously Gryffindors can’t go wrong with many sci-fi books, since the genre is so well suited to the qualities that make them identify with this house in the first place.
But if you’re a Gryffindor looking for what to read next, and you can’t get enough sci-fi, the one book that you should put at the top of your TBR list is Luna: New Moon by Ian McDonald. And if you like it, good news — the sequel (Luna: Wolf Moon) is now available. Here’s why Luna: New Moon will be every Gryffindor’s new favorite sci-fi novel.

domain: library


Design Constraints University of Western Australia
ESE Einfuhrung in Software Engineering 8. User Interface Design Prof. O. Nierstrasz... Design Constraints Software Engineering Design Lecture 9 2 Design Goals Before leaping from Requirements Analysis into System Design, you should ensure that you have identified the design goals for your system Many design goals can be inferred from the non-functional requirements or the application domain . Others should be checked with the client. Design Goals need to be stated …
User Interface Design â€“ Methods and Qualities of a Good
296 Part Five User Interface Design and Software Engineering 2.1 Visibility of system status To construct a system where the users find good visibility, the designer must think in... [caption id="attachment_25030" align="alignleft" width="235" caption="Software Engineering - Pressman 5th edition"] [/caption] Course Title: SOFTWARE ENGINEERING
A SCARCE RESOURCE IN UNDERGRADUATE SOFTWARE ENGINEERING
a software pdf - User Interface Design Designing effective interfaces for software systems Importance of user interface 2 aˆ? System users often judge a system by its interface rather than its functionality aˆ? A poorly designed interface can cause a user to make catastrophic errors aˆ? Poor user interface design is the reason why so many software systems Wed, 19 Dec 2018 08:44:00 oracle 11g database administration pdf cation in Microsoft Access (MS-Access). We assume that the user interface has been designed already as a paper-based mockup (a prototype). How to design a good user interface is a separate story explained in User Interface Design - a Software Engineering Per-spective, by Soren Lauesen. After design, development continues with constructing the database, constructing the user interface…
se361 Chapter 11 Software Engineering at RIT
user interface is the software. Interface design is important for several reasons. First of all the more intuitive the user interface the easier it is to use, and the easier it is to use the cheaper it is. The better the user interface the easier it is to train people to use it, reducing your training costs. The better your user interface the less help people will need to use it, reducing your convert pdf to epub software free CS485/540 Software Engineering User Interface Design (Ch. 11) CengizGunay Dept. Math & CS, Emory University Fall2013 SomeslidescourtesyofJoanSmith,RogerPressman,IanSommerville,
How long can it take?
User Interface Design in Software Engineering SE15
- 6.831/6.813 Lecture 9 Notes User interface (UI) software
- A SCARCE RESOURCE IN UNDERGRADUATE SOFTWARE ENGINEERING
- Systems design Wikipedia
User Interface Design In Software Engineering Pdf
the computer hardware or software. Because the design of the user interface includes anything that is visible to the user, inter- face design extends deep into the design of the interactive system as a whole. A good user interface cannot be applied to a system after it is built but must be part of the design process from the beginning. Proper design of a user interface can make a substantial
- Systems design is the process of defining the architecture, modules, interfaces, and data for a system to satisfy specified requirements. Systems design could be seen as the application of systems theory to product development.
- learn software engineering covering user interface design web services and State University - Download Free Lecture Notes-Pdf Link-XVI Fri, 14 Dec 2018 20:53:00 GMT
- [caption id="attachment_25030" align="alignleft" width="235" caption="Software Engineering - Pressman 5th edition"] [/caption] Course Title: SOFTWARE ENGINEERING
- Software Engineering Using the most recent technologies, macio designs and implements interactive systems – from micro-controllers to control stations and SCADA systems.


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Asia’s Future Farms
Asia is already the world’s largest food market, and its population is expected to increase to five billion by 2050. To ensure adequate food supplies, the region's governments will have to promote a new agricultural model that enables farmers to increase yields, cut costs, and adapt to climate change.
MANILA – Food shortages are a distant memory for many people in Asia. But as the region struggles to feed and nourish a booming population, they could become a painful fact of life again.
Asia is already the world’s largest food market, and by 2050 its population is expected to grow to five billion – an increase of 900 million people. Owing to its expanding middle class, the region will likely account for half of the global increase in annual beef and poultry consumption and over three quarters of the rise in fish consumption between now and 2030. And by then, more than 60% of total cereal demand in the developing world will come from South and East Asia. To keep up with this growing demand, food production will have to increase by 60-70% compared to a decade ago.
Ideally, Asia’s farms could simply expand their production. But they are woefully ill-equipped to do so. To produce a sufficient amount of food, Asia’s farms will need to undergo a twenty-first-century transformation.


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I had the pleasure of photographing little Sofia and her mom a few days ago in their home in Vaughn. They were referred to me by my wonderful client, Shazeen (see a few posts ago, she’s the one who could teach a course on what to wear for your family portraits).
Sofia has the most gorgeous big brown eyes, and a shock of thick black hair. I know you can’t help but notice the hemangioma birthmark over her right eye, but honestly after a few minutes with her, and in editing the photos, I don’t notice it anymore. This birthmark should fade and disappear as Sofia grows up so the question is, do we photoshop it out as if it never existed or leave it be? My personal philosophy is that photoshop should not change history, only enhance your memory of it. So for example, I wouldn’t photoshop an ex-boyfriend out of a group photo, but I would happily fade out stretch marks on an expectant mom’s belly after a maternity shoot. Anyhow, I’m getting off-topic, but it does lead to an interesting debate right?
I was inspired from the previous week’s wedding so asked Sofia’s mom to bring out some of her saris and scarves to use as backdrops. Sofia told us quickly that she didn’t enjoy the prickly sequins on the beautiful fuschia scarf so we improvised quickly and draped it around her instead. Here are just a few from the shoot. Enjoy!
It was touch and go with the weather last week wasn’t it? One day I was bragging about walking the dogs in sandals and the next I was looking for my socks again. Today’s weather reminds me about the lovely baby Sydney, who I had the pleasure of shooting recently. Here she is in a lovely spring frock from her grandma. I love a smiling baby as much as anyone else but I’m usually most charmed by the more inquisitive expressions where you can really see them thinking.
Pre-amble: These photos have absolutely nothing to do with my blog entry below. Even though they are over three years old (and by extension, demonstrating my skill-set as a photographer three years ago), they are some of the most popular and still garner a great response. With the website make-over I just want to make sure they survives the migration. By the way, that baby is about to turn four in a few short months. Anyways…
I shot an award ceremony luncheon today at the University of Toronto and was struck by the wistful way the staff was talking about getting outside to take a walk at the expense of interupting a particularly productive work groove; or taking vacation time at the ‘right’ time of year to avoid the stress of playing catch up upon their return. (Today is March 18, 2010 and Toronto has been enjoying a week of sun and warmth – you know, the kind that prompts you to dig out your sandals and tank tops).
I felt like I was observing from a different universe. As a self-employed person I have, for the most part, the luxury to control my schedule. I get to spend time with my daughter and pets at home. I can choose to sit outside while answering emails, or take that walk and explore our neighbourhood. And when I work (especially for weddings), it’s intense work-mode with the bonus of getting to know and photograph fabulous clients. I have the best job in the world.
This weekend I will be attending a two day workshop for photographers. It was something I heard about and thought, in that same wistful tone of an office worker, oh if only I could go/I should be saving my pennies for that new piece of equipment/I should spend time with my husband/I should etc etc. All valid reasons but nonetheless excuses. But then, like a fairy-godmother (only in the wish-granting department) my fellow photographer Bryan Caporicci (who will be speaking at the workshop with another photographer I admire greatly, Robert Nowell), granted me a complementary pass to the workshop! Thank you!
So, to pay it forward, I am also going to grant a wish. I don’t want the message to be lost in what has become a very long write-up so look out for an upcoming blog post on the subject. In order to tell the story properly I will also need to get permission from someone involved in a past deed.
Post-amble: I noticed while proof-reading that I used a lot of commas and was reminded of the humorous reaction to excessive comma usage by one of the protagonists in “The Elegance of the Hedgehog” by Muriel Barbery. I recommend that book if you are in the mood for some often droll philosophical ramblings and social observations. There is a plot but it takes a while to get going.
As a photographer I get the best seats in the house for some of the most important moments in people’s lives. It is a privileged point of view which I get to share, preserved in images that later become part of the collective memory of the events. I think one of the best compliments I’ve received was from an expectant dad who upon review of their maternity shots told me that the photos made things look way better than what he saw in real life.
This same expectant dad is now really a dad and today I got to visit them at the hospital. Baby Owen was barely 18 hours old when I photographed him! Mom and dad were both beaming with pride.
Congratulations! And thank you for letting me in on these first few hours of Owen’s life.
The Olympics are over and suddenly there is nothing worth watching on TV… guess it’s time to get back on the computer! Here is my favourite model, a proud Canadian!

domain: artistic


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Why are sponges so SPECIAL?
The most ancient of all animals, sponges are really weird creatures! Don't search for eyes or nose - they don't even have organs. Yet they are extremely complex and fascinating organisms. You will find sponges in every aquatic system in the world - be it salty, brackish or freshwater - and don't be surprised if they are so many to literally dominate the place. The vast majority of sponges are filter feeders, actually exceptional ones, but a few carnivorous species are also present (and yes: they have no mouth!).
Typically, sponges also host huge and varied assemblages of microbes the role of which is still the subject of intense research. Microbes are involved in the synthesis of at least some of the thousands bioactive compounds scientists are finding in sponges, but many others appear to be original sponge-produced molecules.
Bioactive compounds that could be transformed in powerful medicines are just one of the reasons why sponges are so important. Silica structures, collagen and entire skeletons are further valuable materials we may derive from them. Furthermore, sponges play key-roles in their habitats by affecting the cycle of energy and matter, creating 3D frameworks useful for other organisms, eroding the substrate and much more.

domain: chemistry


ASHEBORO, N.C. — Some good news for your afternoon!
The North Carolina Zoo welcomed a new baby giraffe on Saturday, May 20.
Leia, a 13-year-old giraffe, is a first-time mom and is taking on her new duties in stride.
The calf is a healthy baby boy and is already about six feet tall and 145 lbs., which is within the parameters of a healthy calf, said the Zoo.
The calf joins as the fifth member of the herd, with males Turbo and Jack (the calf's father) and females Leia and Amelia, said the Zoo.
“Leia and her calf are doing amazingly well. Our team could not be prouder of how attentive Leia has been with her firstborn," said giraffe zookeepers Kristi Myers, Jason Balder, Mary Wilson, and Kelly Davis.
Right now, the Zoo said mom and baby are bonding in private, but the zoo will be determining when they can enter the public eye with the rest of the herd.
"This new arrival brings the team lots of happiness and excitement to have some young, spunky energy around. The rest of the giraffe tower - Jack, Turbo and Amelia - are all very curious of the newbie and are bopping noses whenever they can,” the zookeepers continued.
“The giraffes at the North Carolina Zoo serve as ambassadors for their wild cousins, giving our guests the opportunity to learn about these majestic creatures and the conservation challenges they face. The Zoo’s direct engagement with conservation in Africa means that every Zoo visitor is helping to ensure the future of this and other species," said the North Carolina Zoo Director and CEO, Pat Simmons.
Giraffes are the tallest land animals, with female giraffes growing up to 14 feet tall and male giraffes growing to a staggering 18 feet tall. This means a giraffe could snoop through your second-story window, according to the Zoo.
Giraffes can live up to 25 years in the wild and longer under the care of humans, said the Zoo.
Additionally, no two giraffes have the same coat pattern, wrote the Zoo.
Giraffes "are listed as a "Vulnerable" species according to the International Union for Conservation of Nature (IUCN), and approximately 68,000 are found in the wild, with numbers decreasing because of habitat loss, poaching (illegal hunting), and disease threatening their distribution throughout Africa," wrote the NC Zoo.
You can learn more about the NC Zoo's giraffe conservation work and research on their blog.


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By Lori Nichols, DVM
February may be National Pet Dental Health Awareness Month but oral health is important all year long. Early detection and treatment is critical for preventing problems further down the road. Periodontal disease can cause serious pain making it hard for pets to eat food and groom themselves.
From brushing at home to annual exams, there are steps to take to address your pet’s oral health:
Learn the signs of oral health issues – Does your pet have bad breath? Are they drooling excessively? These may be signs of a health issue. Learn what other signs to look for on the American Veterinary Association’s website.
Learn how to brush your pet’s teeth – Brushing your pet’s teeth is one of the most important at-home treatments you can offer your pet. Daily brushing is best but not always possible. Even a couple times a week is beneficial. Did you do a good job? Show it off on Facebook or Instagram @SPCATampaBay with #petdental #smile.
Get annual exams. Like regular annual check-ups, pets should have dental cleanings once a year. During the cleaning, pets are put under anesthesia and given a full mouth cleaning, polish and x-rays – similar to visiting the dentist. Vets use anesthesia to properly clean the pets’ teeth while protecting the pet from swallowing or biting harmful products.
Use pet-friendly products. Dental chews, water additives and a dental-friendly diet are among the products good for helping to maintain dental health. The Veterinary Oral Health Council reviews products to determine if they are pet-safe. Approved products will have a label on its packaging, and the Veterinary Oral Health Council has a list of products on their website. Set up your dental appointment by visiting spcatampabay.org/veterinary-center or call 727-220-1770.
Dr. Lori Nichols graduated from the Mississippi State University College of Veterinary Medicine in 2017 before joining the SPCA Tampa Bay team in July 2019. Her professional interests include feline medicine, shelter medicine, endocrinology and soft tissue surgery.

domain: pet


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By I. Kurt. Clarke College.
Immunological factors The immune process is essential for protection against micro-organisms and parasites buy liv 52 60 ml lowest price treatment deep vein thrombosis. For example purchase liv 52 120 ml on-line medicine side effects, bronchial asthma can occur due to exaggerated immune response to the harmless pollen purchase liv 52 200 ml with visa symptoms kidney failure dogs. Immunodeficiency This is due to deficiency of a component of the immune system which leads to increased susceptibility to different diseases cheap 200 ml liv 52 with visa treatment nausea. Autoimmunity This is an abnormal (exaggerated) immune reaction against the self antigens of the host. For example, type 1 diabetes mellitus is caused by autoimmune destruction of the beta cells of the islets of Langerhans of the pancreas. Psychogenic factors The mental stresses imposed by conditions of life, particularly in technologically advanced communities, are probably contributory factors in some groups of diseases. Genetic Factors These are hereditary factors that are inherited genetically from parents. Course of disease The course of disease is shown with a simplified diagram as follows. Exposure Biological onset Clinical onset Permanent damage Death Latency period The course of a disease in the absence of any intervention is called the natural history of the disease. The different stages in the natural history of disease include: a) Exposure to various risk factors (causative agents) b) Latency, period between exposure and biological onset of disease c) Biological onset of disease; this marks the initiation of the disease process, however, without any sign or symptom. Following biological onset of disease, it may remain asymptomatic or subclinical (i. The expression of the disease may be variable in severity or in terms of range of manifestations. Clinical & biologic death Clinical death Clinical death is the reversible transmission between life and biologic death. Clinical death is defined as the period of respiratory, circulatory and brain arrest during which initiation of resuscitation can lead to recovery. Clinical death begins with either the last agonal inhalation or the last cardiac contraction. Signs indicating clinical death are The patient is without pulse or blood pressure and is completely unresponsive to the most painful stimulus. For example, during intubations, respiration may be restored in response to stimulation of the receptors of the superior laryngeal nerve, the nucleus of which is located in the medulla oblongata near the respiratory center. It manifests with irreversible cessation of circulatory and respiratory functions, or irreversible cessation of all functions of the entire brain, including brain stem. However, one should notice that there are internationally accepted criteria to diagnose biological death. S Israel; General Pathology, Churchill Livingston Edinburgh and th London, 4 edition, 1974 th 5. Define hyperplasia, hypertrophy, atrophy, & Metaplasia & list some of their causes. Which of these outcomes occur depends on both the injurious agent & on cellular factors. In other words, the result depends on the type, severity, & duration of the injury & on the type of the cell. This chapter covers the types of cellular adaptation, reversible cell injury, & cell death in that order. Types of cellular adaptation The types of cellular adaptation include hypertrophy, atrophy, hyperplasia, & metaplasia. Increased workload leads to increased protein synthesis & increased size & number of intracellular organelles which, in turn, leads to increased cell size. Examples: the enlargement of the left ventricle in hypertensive heart disease & the increase in skeletal muscle during sternous exercise. It can be physiological as in enlargement of the breast during pregnancy or it can pathological as in endometrial hyperplasia. The atrophic cell shows autophagic vacuoles which contain cellular debris from degraded organelles. Metaplasia Metaplasia is the replacement of one differentiated tissue by another differentiated tissue. Squamous metaplasia This is replacement of another type of epithelium by squamous epithelium. For example, the columnar epithelium of the bronchus can be replaced by squamous epithelium in cigarette smokers 2. Osseous metaplasia This replacement of a connective tissue by bone, for example at sites of injury. Reversible cellular changes & accumulations Even though there are many different kinds of reversible cellular changes & accumulations, here we will only mention fatty change & accumulation of pigments. These etiologies cause accumulation of fat in the hepatocytes by the following mechanisms: a. Melanin Melanin is a brownish-black pigment produced by the melanocytes found in the skin. Bilirubin Bilirubin is a yellowish pigment, mainly produced during the degradation of hemoglobin. Excess accumulation of bilirubin causes yellowish discoloration of the sclerae, mucosae, & internal organs. Hemolytic anemia Hemolytic anemia is characterized by increased destruction of red blood cells. Biliary obstruction This is obstruction of intrahepatic or extrahepatic bile ducts. Hepatocellular disease This is associated with failure of conjugation of bilirubin. It appears in tissues as golden brown amorphous aggregates & is identified by its staining reaction (blue 17 color) with the Prussian blue dye. Hemosiderin exists normally in small amounts within tissue macrophages of the bone marrow, liver, & spleen as physiologic iron stores. Hemosiderosis When accumulation of hemosiderin is primarily within tissue macrophages & is not associated with tissue damage, it is called hemosiderosis. Necrosis In necrosis, excess fluid enters the cell, swells it, & ruptures its membrane which kills it. After the cell has died, intracellular degradative reactions occur within a living organism. Ischemia can be caused by obstruction of arterial blood flow the most common cause, or by decreased perfusion of tissues by oxygen-carrying blood as occurs in cardiac failure, hypotension, & shock. The cell injury that results following hypoxia can be divided into early & late stages: 1. Failure of the cell membrane Na K pump, which leads to increased intracellular Na & water, which cause cellular & organelle swelling. Cellular swelling (hydropic change) is characterized by the presence of large vacuoles in the cytoplasm. It is caused by massive calcium influx & very low pH, which lead to activation of enzymes, which damage the cell membrane& organelle membranes. Free radical-induced injury Free radical is any molecule with a single unpaired electron in the outer orbital. Cell membrane damage Direct cell membrane damage as in extremes of temprature, toxins, or viruses, or indirect cell membrane damage as in the case of hypoxia can lead to cell death by disrupting the homeostasis of the cell. Increased intracellular calcium level Increased intracellular calcium level is a common pathway via which different causes of cell injury operate. For example, the cell membrane damage leads to increased intracellular calcium level.
Prevention and control of Onchocerciasis Drug treatment: the development of ivermectin in the 1980s provided a safe order liv 52 100 ml overnight delivery symptoms ruptured ovarian cyst, effective drug for killing microfilariae in infected people generic 100 ml liv 52 with visa symptoms anxiety. Vector control: insecticide spraying to control black flies has proved successful in certain areas discount 200 ml liv 52 fast delivery 5 medications. Simulium larvae are killed by applying insecticides via aerial spraying over breeding sites in fast- flowing rivers liv 52 100 ml discount medicine 5 rights. Following interruption of transmission, the reservoir of adult worms dies out in humans after 14 years. The objective is to create, by 2007, sustainable community-directed distribution systems using ivermectin. Mansonella Ozzardi Mansonella ozzardi is a filarial parasite of humans that is usually regarded as non-pathogenic, although it has been reported as causing morbidity in Colombia and Brazil. Although insecticidal fogging or spraying of vegetation though to harbour resting adult blackflies has occasionally been undertaken, this approach results in very temporary and localized control. The only practical method at present available fro the control of blackflies is the application of insecticides to their breeding places to kill the larvae. Insecticides need be applied to only a few selected sites on watercourses for some 15-30 min, because as the insecticide is carried downstream it kills simuliid larvae over long stretches of water. The flow rates of the water and its depth are used to calculate the quantity of insecticide to be released. If treatment is not repeated at intervals throughout the year, gravid female adult dispersing into the area from untreated areas will probably cause recolonization. Under these conditions aerial applications from small aircraft or helicopters have been used. Considerable information has been gained in North America on the chemical control of pestiferous blackflies. This programme originally involved seven west African countries but has now expanded to cover 11 countries. Because of the appearance of temephos resistance (in 1980) in some populations and species of the S. Larviciding will continue in the newer areas covered by the programme until the year 2000, thus giving insecticidal control in these areas fro 14 years, the period required to eliminate O. Alternata There are some 700 species of phlebotomine sandflies in five genera within the subfamily phlebot00 ominae of the family psychodidae. The genus phlebotomus occurs only in the Old World, especially in southern parts of the northern temprate areas such as the Mediterranean region. The genus also occurs in the Old world 102 tropics, but there are not many species in tropical Africa, especially West Africa. Most phlebotomus species inhabit semiarid and savannah areas in preference to forests. Lutzomyia species by contrast are found only in the New World tropics, occurring mostly in the forested areas of Central and South America Sergentomyia species are also confined to the Old World, being especially common in the Indian subregion, but also occurring in other areas such as Africa and Central Asia. The only other blood-sucking flies which are as small as this are some species of biting midges (Ceratopogonidae), but these have non-hairy wings and differ in many other details. Phlebotomine sandflies have the head, thorax, wings and abdomen densely covered with long hairs. The antennae are are long and composed of small bead-like segments with short hairs; they are similar in both sexes. At their base are pair of five-segmented maxillary palps 103 which are relatively conspicuous and droop downwards. Wings are lanceolate in outline and quite distinct from the wings of other biting flies. The phelebotominae can be distinguished from other subfamilies of the family psychodidae, which they may superficially resemble, by the wings. In sandflies the wings are held erect over the body when the fly is at rest, whereas in non-biting psychodid flies they are folded, roof like, over the body. Although it usually lasts less than 45 days, Breeding is in the soil independent of surface water. In the Old World many phletobomus species bite people whereas most species of sergentomyia feed mainly on reptiles and rarely bite humans. In the tropical Americas Lutzomyia species feed on a variety of mammals including humans. Biting is usually restricted to crepuscular and nocturnal periods but people 105 may be bitten during the day in darkened rooms, or in forests during overcast days. Most species feed out of doors (exophagic) but a few also feed indoors (endophagic). Adults are weak fliers and do not usually disperse more than a few hundred metres from their breeding places. Sandflies have a characteristic hopping type of flight so that there may be several short flights and landings before females settle on their hosts. Species that commonly rest in houses (endophilic) before or after feeding on humans are often referred to as domestic or peridomestic species. Examples are phlebotomus papatasi in the Mediterranean area and Lutzomyia longipalpis in South America. In temperate areas of the Old World sandflies are seasonal in their appearance and adults occur only in the summer months. In tropical areas some species appear to be common more or less throughout the year, but in other species there may be well marked changes abundance of adults related to the dry and wet seasons. Nuisance Apart from their importance as disease vectors, sand flies may constitute a serious, but usually localized bitting nuisance. In previously sensitized people their bite may result in severe and almostintolerable irritations, a condition known in the middle east as harara. Leishmaniasis This is a term used to describe a number of closely related diseases caused by several distinct species, subspecies and strains of Leishmania parasites. Distribution Leishmaniasis is wide spreaded in 22 countries in the New World and in 66 nations in the Old World, it is not found in South-east Asia. Causative agent Parasitic protozoa of the genus Leishmania, transmitted to humans by sand flies. Over 20 species and subspecies infect humans, each causing a different spectrum of symptoms. As the sand fly feeds, promastigote forms of the leishmania parasite enter the human host via the proboscis. Within the human host, the promastigote forms of the parasite are ingested by macrophage where they metamorphose into amastigote forms and reproduce by binary fission. They increase in number until the cell eventually bursts, then infect other phagocytic cells and continue the cycle. Clinical Forms The diseases occur in three main clinical forms: cutaneous, mucocutaneous, and visceral leishmaniasis and a fourth less common form termed diffuse cutaneous leishmaniasis. They develop a flagellum and attach themselves to either the mid-gut or the hindgut wall. After further development they become infective metacyclic promastigotes and migrate to the anterior part of the mid-gut and from there to the oesophagus. After 4-12 days from taking an infective blood-meal the metacyclic forms may be found in the mouth parts from which they are introduced into a new host during feeding. Infective flies often probe more often than uninfected flies, thus maximizing transmission of parasites during blood-feeding.
Although I included this recipe in every other book I wrote cheap 60 ml liv 52 with mastercard administering medications 7th edition, I am not including it here because usually an advanced cancer sufferer can not wait until the black walnut trees are in season purchase liv 52 120 ml overnight delivery treatment yeast infection women. The tincture must be greenish to be useful (and order liv 52 120 ml line treatment yeast infection home remedies, of course cheap 120 ml liv 52 mastercard xanthine medications, free from pollutants). Bowel Program Bacteria are always at the root of bowel problems, such as pain, bloating and gassiness. They can not be killed by zapping, because the high frequency current does not penetrate the bowel contents. One reason bowel bacteria are so hard to eradicate is that we are constantly reinfecting ourselves by keeping a supply on our hands and under our fingernails. Take extra magnesium (300 mg magnesium oxide, 2 or 3 a day), and drink a cup of hot water upon rising in the morning. With this powerful approach, even a bad bacterial problem should clear up in two days. Afterward, you must continue to eat only sterilized food, until your natural immune power is restored. Enemas If you should fail to have a bowel movement in a single day it is a serious matter. An ill person cannot afford to fill up fur- ther with the ammonia, and toxic amines that bowel bacteria produce. But the purpose is even greater: to eliminate parasites, and toxins drained from your tumors. But in just a few weeks of daily cleansing, the pocket will shrink and may even disappear. As soon as the 21 Day Pro- gram is completed and if natural evacuation is possible, stop taking enemas: Hemorrhoids can be made worse by them. To avoid hemorrhoids, do not strain and always cleanse your bottom with wet paper, not dry paper. If hemorrhoid is large, use a gloved finger (cut fingers off thin plastic gloves; wear one at a time on middle finger, lu- bricate with cornstarch; push hemorrhoid as far in as possible). Plain Enema If you have none of the other solutions available, use plain salt water, 1 tsp. Coffee Enema Although this has profound effects that are beneficial, you must take special precautions due to asbestos pollution of all coffees tested. They also contain Ascaris eggs and Sorghum mold (the variety that causes purpura and strokes). Giving Yourself The Perfect Enema Any drop you spill and everything you use to do the enema will somehow contaminate your bathroom. This may be workable for the small squeeze-bottle of ready-made solution you can purchase. Wipe away the grease that comes with it on the applica- tor; it is sure to be a petroleum product and be tainted with ben- zene. After filling the container with the enema solution, run some through the tubing until the air is out of it and close the pinch- cock. At any time you may close the valve, withdraw the applicator, and place it on the shopping bag. Cleaning up the apparatus, the bathroom, and yourself: This topic is seldom discussed, but very important. Notice that some bowel contents have entered the container by reflux action, which is unavoidable. For this reason you must never, never use anybody elses apparatus, no matter how clean it looks. Repeat until it appears clean; this is appearance only; you must now sterilize it. Fill it with water and add Lugols iodine or povidone iodine until in- tensely red in color. And extra enjoyment if you learn to make them with varia- tionsespecially if you need to produce a gallon of urine a day! When kidneys or bladder are actually involved in the cancer, gradually increase the dose to double the regular amounts. Measure cup of each root and set them to soak, together in 10 cups of cold tap water, using a non-metal container and a non-metal lid (a dinner plate will do). Although this saves a few dollars, advanced cancer sufferers should use new roots each time. You need to do the kidney cleanse for six weeks to get good results, longer for severe problems. Dose: each morning, pour together cup of the root mix- ture and cup parsley water, filling a large mug. Do not drink it all at once or you will get a stomach ache and feel pressure in your bladder. You do not need to duplicate the B6 and magnesium doses if you are already on them. Some notes on this recipe: this herbal tea, as well as the parsley, can easily spoil. If you sterilize it in the morning you may take it to work without refrigerating it (use a glass container). If the ones you buy are barely fragrant, they have lost their active in- gredients; switch to a different supplier. Liver Herbs Dont confuse these liver herbs with the next recipe for the Liver Cleanse. This recipe contains herbs traditionally used to help the liver function, while the Liver Cleanse gets gallstones out. Liver Cleanse Cleansing the liver of gallstones dramatically improves di- gestion, which is the basis of your whole health. But it should not be done before the parasite program, and for best results should follow the kidney cleanse. The liver is full of tubes (biliary tubing) that deliver the bile to one large tube (the common bile duct). The gallbladder is at- tached to the common bile duct and acts as a storage reservoir. Eating fat or protein triggers the gallbladder to squeeze itself empty after about twenty minutes, and the stored bile finishes its trip down the common bile duct to the intestine. For many persons, including children, the biliary tubing is choked with gallstones. Not only that, most are too small and not calcified, a prerequi- site for visibility on X-ray. There are over half a dozen varieties of gallstones, most of which have cholesterol crystals in them. Other stones are compos- itesmade of many smaller onesshowing that they regrouped in the bile ducts some time after the last cleanse. At the very center of each stone is found a clump of bacte- ria, according to scientists, suggesting that a dead bit of parasite might have started the stone forming. As the stones grow and become more numerous the back pressure on the liver causes it to make less bile. With gallstones, much less cholesterol leaves the body, and cholesterol levels may rise. In this way nests of infection are formed, forever supplying the body with fresh bacteria and parasite stages.
There is a leak if you see bubbles (a three-bladed abdominal or universal Dennis-Browne in the water! Hook up the bladder to the pubic symphysis with close any defect through which a loop of small bowel a temporary stay suture cheap liv 52 60 ml line symptoms lung cancer. Put a long blunt easily purchase liv 52 200 ml online symptoms 9 days past iui, mobilize more of the descending colon proximally instrument into the rectum through the anus to help by incising the lateral peritoneal reflexion further generic liv 52 120 ml fast delivery treatment 4 letter word, and identify the stump 100 ml liv 52 with visa medications used to treat adhd. Then start to dissect it out (the non-absorbable suture You may, rarely, need to mobilize the splenic flexure; placed earlier will also help to find it). Dissect across the make sure you fix the colon to the posterior peritoneum to top and about 5cm down each side (12-15B). Remove the prevent it twisting on an axis from the transverse colon to instrument in the rectal stump and cut it across 1cm from the rectum. Do not be tempted to leave a swab in the distal rectum: If the ends of the bowel are different sizes (the proximal you may forget it or be unable to retrieve it end is usually bigger), place the sutures on the wider end postoperatively. Make an elliptical incision around the colostomy; dissect down to the rectus sheath. Control bleeding carefully so If the lumen is too narrow, or there is a dog-ear at the you can see where you are. If you leave it, anterior and posterior rectus sheaths; a finger inside the obstruction or a leak are inevitable. Re-check if there is still inside just adjacent to the abdominal wall, and amputate it. If so, try again, but if there remains a leak, undo the Mobilize the proximal descending colon by incising its anastomosis and start again. If there is a bleeding vessel beside the bowel, clip Mobilize it sufficiently, so that it reaches the distal stump and tie it. C, place the seromuscular (Lembert) sutures that will draw the 2 ends of the bowel together. Insert the instrument through Look for: the anus and make it come out lateral to the rectal closure (1) Signs of loss of weight, anaemia and jaundice. A primary mass, ascites, a hard craggy liver with Make sure that a monofilament purse-string holds the metastatic tumour, or a hard umbilical (Sister Josephs) rectal end snugly round the shaft of the instrument above nodule. Then release the safety catch Suggesting a lesion in the left colon: colicky abdominal and fire the instrument in one clean movement. Examine the cartridge: if you find 2 complete Suggesting a lesion in the rectum: rectal bleeding, doughnuts of bowel, the anastomosis is complete; diarrhoea, a feeling of incomplete evacuation. If the above investigations are negative and you still It invades locally, spreads to the regional nodes or the liver suspect a carcinoma if there is no colonoscope to hand, (usually late), or through to the peritoneal cavity (late and perform a barium enema. Get a chest radiograph to Colorectal carcinoma is related to a low-fibre and high fat exclude pulmonary metastases. If there is a palpable mass, it might give details of exposure to organochlorine pesticides. Other causes of blood in the stools (haemorrhoids, young adult, who presents with: amoebiasis, and dysentery (26. Other causes of altered bowel habit (bowel infections, (2) An alteration in bowel habit. Other causes of acute-on-chronic obstruction (sigmoid (4) Colicky abdominal pain (incomplete obstruction). An anorectal, rectovesical or rectovaginal faecal fistula schistosomiasis, herbal enemas). This is why this topic is described here, although you may (2) Where the tumour is. Carcinoma of the rectum usually presents late, because it (4) If the bowel is obstructed or not. If there is no obstruction, you will be plaque, or an ulcer with hard rolled edges, leaving blood able to perform a planned elective operation. Enemas only clear the distal part, so you Do not mistake it from a fissure or haemorrhoids! Evidence now suggests that total bowel preparation may be unhelpful, although an obviously full colon must increase the risk of infection if there is spillage. It may just be simpler to restrict the diet to yoghurt and foods of low residue 1wk pre-operatively. If you use bowel preparation, you must replace fluid lost by osmosis into the bowel by plenty of oral fluids. Start metronidazole 400 mg tid, and restrict to oral fluids only on the evening before operation. It is a firm mass involving the colon; an inflammatory mass may look and feel the same, so keep an open mind! It may be unresectable if it is fixed to the pelvic wall, the abdominal wall, or the bladder. You will have to assess how readily you can resect the tumour: a more experienced surgeon may manage a more extensive resection, but the prognosis may not necessarily be improved thereby. If radiotherapy & chemotherapy (usually 5-fluorouracil) is available, it may shrink an unresectable tumour and make it resectable. It is inoperable if there are palpable masses in the liver, widespread metastatic mesenteric lymphadenopathy, or malignant ascites (or of course metastases elsewhere outside the abdomen. The contents of the large bowel are always loaded with bacteria, so when you have to operate in an emergency for obstruction avoid contaminating the peritoneal cavity, and try to decompress the proximal colon as much as you can. When you anastomose the Solutions: G, right hemicolectomy with an end-to-end ileocolic anastomosis. I, excision ileum to the transverse colon, remember to save as much of tumour of the left colon with protective loop colostomy. J, excision ileum as you can, because its last few centimetres are the of tumour of the left colon with adjacent colostomy. This wont have any effect on the risk of an anastomotic leakage, but will make it less dangerous for (c) If the colon is obstructed: the patient. If the tumour is not resectable (12-16D), (2);If the condition is poor or you are inexperienced, make make a defunctioning right transverse loop colostomy a bypass, as in (b). This might thereby mean missing the (11-13): this is preferable to a sigmoid colostomy which opportunity of a curative resection, however. Perform an end-to-end bring out the proximal bowel as an end-colostomy, anastomosis (12-16M). If not, resect more bowel, but not more confident with bowel anastomoses, you can clean out the mesentery. Try to remove the anastomosis; make sure you test it afterwards by filling the tumour and its lymphatic drainage area to make a pelvis with water and blowing air up the rectum (12. If necessary, If the tumour is in the middle or lower rectum try to get a more experienced colleague to perform a wider (12-16E): resection if that would be possible. Biopsy the tumour through a proctoscope or preferably with a non-absorbable suture for the outer layer. If there are liver metastases or a fixed bring the two cut ends out as a double-barrelled colostomy tumour, think hard before you make a colostomy. The patient may live a few more months, but dying with a colostomy will be miserable, especially if colostomy care If the tumour is in the sigmoid or upper rectum is poor. If the tumour is not resectable, it is better to (12-16E): perform a bypass operation, an ileotransverse or colo-colic anastomosis. You may need to mobilize the proximal If a bypass is impossible, however, a colostomy is better colon to make sure it reaches the distal end without than dying in obstruction. When the operation is over, wash out the (posteriorly) in the middle with 2 separate sutures knotted peritoneal cavity with warm fluid; do not insert drains.

domain: medical


text:
Calif. Gov. Jerry Brown and U.S. Interior Secretary Ken Salazar announced a new $23.7 billion proposal that would build a twin tunnel system to carry water from the Sacramento-San Joaquin River Delta over to the southern part of the state.
Water in Southern California has become an intractable problem. The frustration was evident at the press conference, when Brown dropped a four-letter expletive.
"'Analysis paralysis is not why I came back 30 years later to handle some of the same issues,' the 74-year-old former governor said. 'At this stage, as I see many of my friends dying — I went to the funeral of my best friend a couple of weeks ago — I want to get s--- done.'
"The Democratic governor has been seeking a way to move water through or around the Delta since he was governor before. He persuaded the Legislature three decades ago to approve a peripheral canal, but the measure was defeated in a referendum in 1982."
Lauren Sommer reports on the history for today's edition of All Things Considered.
She went to the delta with biologist Julio Adib-Samii who says the current pumps have contributed to the ecological damage of the delta.
"Ten years ago, the Delta's fish populations crashed," Sommer reports. "Chinook salmon numbers went so low, the commercial fishery shut down for two years."
Sommer added: "Federal wildlife agencies stepped in and said water pumping had to slow down during certain times of year to protect fish. That didn't go over well in certain parts of the state."
Today's announcement is supposed to fix all of this. But the project is already facing some tough hurdles.
"State officials admit they don't know just how much water would be diverted through the tunnels or how habitat restoration and decreased flows would affect the fish. They say these questions would be answered through scientific studies that accompany construction over the next 10-15 years.
"Opponents argue it would devastate the delta region, including its ecosystem and agriculture-based economy. They say it's unacceptable to proceed with building the tunnels without knowing up front their impact on imperiled fish species such as salmon and smelt. Officials said the amount of water to be pumped would depend on what is good for the fish."
We'll add audio of Sommer's piece to this post a little later on tonight.
AUDIE CORNISH, HOST:
Today in California, Governor Jerry Brown and U.S. Interior Secretary Ken Salazar announced a new project. It would deliver water from the Sierra Nevada Mountains to 25 million people stretching from Silicon Valley to San Diego. And it would cost $17 billion.
Lauren Sommer, of member station KQED, tells us more about this new plan to manage California's water and how it came about.
LAUREN SOMMER, BYLINE: Almost all of the state's water is found in Northern California, the very top part. The rest of the state is where most of the people live. This problem was painfully obvious to state planners a century ago. They knew, for California to grow, they had to move the water south.
RONALD SILVA: Right now, we're situated on the upstream side of the C.W. Bill Jones Pumping Plant.
SOMMER: Ronald Silva of the Bureau of Reclamation runs this plant about 60 miles east of San Francisco. It pumps millions of gallons every minute. The water goes into canals that stretch all the way to Los Angeles, Silicon Valley and farmland in the Central Valley. Where it comes from?
SILVA: The water is coming out of the delta.
SOMMER: The Sacramento-San Joaquin Delta, an inland estuary where California's two largest rivers meet before they flow out to San Francisco Bay. To water planners, it was the perfect place to tap into. That is, until the problems started. Ten years ago, the delta's fish populations crashed. Chinook salmon numbers went so low, the commercial fishery shut down for two years. Biologists say this happened for a number of reasons - habitat loss, invasive species, pollution and the water pumps.
BARRY NELSON: The pumps in the south delta are so powerful that they literally reverse the direction of flow.
SOMMER: Barry Nelson is with the nonprofit Natural Resources Defense Council.
NELSON: Very easy for those fish to follow that water and get sucked right into the pumps.
SOMMER: Federal wildlife agencies stepped in and said water pumping had to slow down during certain times of year to protect fish. That didn't go over well in certain parts of the state.
JASON PELTIER: Our farmers have seen a rough couple decades dealing with uncertainty, unpredictability.
SOMMER: That's Jason Peltier with Westlands Water District, an agricultural area in the Central Valley that depends on water from the delta.
PELTIER: You can't get a loan to farm unless you can show the banker what water you have.
SOMMER: John Laird is California's Secretary for Natural Resources.
JOHN LAIRD: There was lawsuit after lawsuit and it got to the point that it made much more sense to look at the entire delta as a whole.
SOMMER: The state announced today it hopes to do that with something called the peripheral tunnel. The 35-mile project would take water from farther upstream, bypassing the delta. Supporters say that would make the water supply more reliable. It's not a new idea. Laird points to 1982, when California voters defeated a similar plan.
LAIRD: The real debate is not the tunnel itself. It's how much water and when can it flow through the tunnel.
SOMMER: State and federal wildlife agencies raised a red flag a few months ago, saying a large project could harm the delta's endangered species. Laird says they'll restore thousands of acres of wetlands to compensate. California voters would be on the hook for up to 3 billion to pay for that, while water users would pay the remaining 14 billion for the tunnel. It's a tough sell in today's economy, but state officials say a necessary one if the water deadlock is ever going to be broken.
For NPR News, I'm Lauren Sommer in San Francisco. Transcript provided by NPR, Copyright NPR.


text:
Written by Anette Duensing, M.D.
Molecular mechanisms can help identify GIST treatment options. GISTs are the most common mesenchymal tumors of the gastrointestinal tract and are caused by activating mutations in the KIT or PDGFRA receptor tyrosine kinase (RTK) genes 1-3. Although they can be effectively treated with the small molecule kinase inhibitor imatinib mesylate (Gleevec®) 4, approximately 50 percent of the patients develop resistance to the drug during the first two years of treatment 5. A Food and Drug Administrationapproved second-line therapy (Sutent®) and an array of experimental third-line therapeutic options exist 6, but most of these compounds also target the activated KIT or PDGFRA kinases. This “kinase-centric” approach is not unproblematic, however, because the most prominent imatinibresistance mechanism involves secondary mutations in the KIT/ PDGFRA genes themselves 7.
Our laboratory therefore uses different approaches to identify novel treatment strategies. One approach focuses on dissecting the mechanisms of action of imatinib to identify the molecular players that are involved in imatinib-induced apoptosis and quiescence 8 (LRG’s October 2009 Newsletter issue). In a second step we are using our knowledge to target these molecules for therapeutic purposes.
We have previously shown that imatinib treatment of GIST cells leads to increased amounts of a certain cellular protein, histone H2AX 9,10 (also see LRG Newsletter December 2007). In our study, we could show that this process is causatively involved in killing GIST cells. A second finding in our study involved the notion that the amount of H2AX contained in a cell is regulated by a pathway that controls protein degradation, the so-called ubiquitin- proteasome machinery.
This discovery was the first step at asking whether it would be possible to increase H2AX levels in GIST cells by a different means than by treatment with imatinib. Based on our findings above, one way of increasing the amounts of H2AX would be by inhibiting its degradation. This could be done through inhibition of the ubiquitin-proteasome machinery. In fact, the concept of proteasome inhibition has been of interest for the pharmaceutical industry for a while, and a number of compounds already exist.
Bortezomib (Velcadeâ) is such a drug and so far the only FDA-approved compound of its kind. Bortezomib is currently used for the treatment of multiple myeloma and mantle cell lymphoma 11. We therefore wanted to test the hypothesis that increasing the amounts of H2AX by inhibiting its degradation with the proteasome inhibitor bortezomib would have a therapeutic effect in GIST cells 12.
We started out testing an array of different concentrations of bortezomib asking whether the compound can induce cell death in GIST cells. Employing various methods for experimental readout, we could confirm that bortezomib is active in GIST. In fact, it was able to kill cells at the same concentrations that are reportedly used to kill multiple myeloma cells – indicating that our results comprised a specific effect of bortezomib in GIST.
However, we were not satisfied with knowing that bortezomib is able to kill GIST cells. We wanted to know more about its mechanism of action and whether our hypothesis was correct – that bortezomib acts through increasing the levels of histone H2AX by inhibiting its degradation (See Figure 1).
So, in a next step we tested whether H2AX levels increased after bortezomib treatment. Using a technique called immunoblotting, we were indeed able to show that the amounts of H2AX were higher in cells that received bortezomib, seeming to prove our hypothesis. By carrying out a number of other experiments, however, we found out that H2AX upregulation is most likely not the only mechanism of action of bortezomib.
While searching for the possibility of an additional mechanism of action of bortezomib, we detected to our surprise that it led to a dramatic reduction of KIT protein levels accompanied by loss of KIT tyrosine phosphorylation. Since it is known that GIST cells are critically dependent on the expression of oncogenic KIT 13, its downregulation most likely plays a substantial role in bortezomib- induced apoptosis in GIST.
It was surprising, however, that treatment with a drug that inhibits degradation of proteins (hence leading to their accumulation) should result in decreased levels of KIT. How could we explain this curious finding? One way through which cells control protein levels is regulating the rate at which they are produced. This process starts with the transcription of the protein’s DNA sequence. When transcription from DNA is reduced, less messenger molecules (RNA) are being made and hence less protein is produced. We therefore tested the possibility that bortezomib could affect the transcription of the KIT gene. Indeed, we found that bortezomib affected the levels of KIT messenger molecules (RNA). However, further tests pointed to the fact that bortezomib affects transcription on a more general level by reducing the transcription of many genes across the cell’s DNA. (It has previously been shown by other researchers that protein degradation is essential for transcription to function properly 14.) In addition, our group has previously found that GIST cells are exceptionally sensitive to transcriptional inhibition 9. Therefore, our results explain very well, why GIST cells are affected by transcriptional inhibition through bortezomib. Taken together, the above results point to a dual mechanism of action of bortezomib in GIST: increasing the amounts of H2AX within the cell, but also decreasing the amounts of active KIT through transcriptional inhibition
Because our initial experiments were carried out in an imatinib-sensitive cell line model (GIST882), we next tested whether bortezomib is active in imatinib -resistant GIST cell lines (in collaboration with LRG Research Team member Sebastian Bauer, University of Essen, Germany). After all, the main goal of our study was to find new therapeutic options for imatinib-resistant GIST patients. To our surprise, these cells were even more sensitive to bortezomib than GIST882 cells. Moreover, cells that were directly derived from an imatinibresistant tumor of a GIST patient also responded to bortezomib treatment, just as we had hoped.
We then went one step further and treated mice engineered to get GIST with bortezomib (in collaboration with LRG Research Team member Brian Rubin, Cleveland Clinic). Although the results from these studies were not as clear-cut as the studies in the tissue culture dish, some mice clearly responded to the treatment. These promising results indicate that bortezomib indeed has an effect in vivo further corroborating our approach.
Taken together, our results provide a compelling rationale for clinical trials testing the efficacy of bortezomib in GIST patients 15. However, bortezomib has known disadvantages with respect to adverse effects and its efficacy in solid tumors – potentially because of problems concerning its bioavailability. Because of these issues, there is an increased interest in the development of second-generation proteasome inhibitors with improved pharmacologic characteristics. Some of these compounds have already entered advanced clinical trials for multiple myeloma. Our laboratory has recently started testing several of these novel compounds in GIST with very promising preliminary results.
In summary, our approach to dissect the molecular pathways that are involved in imatinib-induced cell death were successful in identifying a novel therapeutic target (histone H2AX) and have led to the discovery of a new therapeutic strategy for the treatment of GIST, namely, the use of inhibitors of the ubiquitin-proteasome machinery.
1. Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Muhammad Tunio G, Matsuzawa Y, Kanakura Y, Shinomura Y, Kitamura Y. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998, 279:577- 580.
2. Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, Hibbard MK, Chen CJ, Xiao S, Tuveson DA, Demetri GD, Fletcher CD, Fletcher JA. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 2001, 61:8118 -8121.
3. Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen CJ, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CD, Fletcher JA. PDGFRA activating mutations in gastrointestinal stromal tumors. Science 2003, 299:708- 710.
4. Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese, B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002, 347:472-480.
5. Blanke CD, Demetri GD, von Mehren M, Heinrich MC, Eisenberg B, Fletcher JA, Corless CL, Fletcher CD, Roberts PJ, Heinz D, Wehre E, Nikolova Z, Joensuu H. Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT. J Clin Oncol 2008, 26:620-625.
6. Demetri GD, van Oosterom AT, Garrett CR, Blackstein ME, Shah MH, Verweij J, McArthur G, Judson IR, Heinrich MC, Morgan JA, Desai J, Fletcher CD, George S, Bello CL, Huang X, Baum CM, Casali PG. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 2006, 368:1329-1338.
7. Antonescu CR, Besmer P, Guo T, Arkun K, Hom G, Koryotowski B, Leversha MA, Jeffrey PD, Desantis D, Singer S, Brennan MF, Maki RG, DeMatteo RP. Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clin Cancer Res 2005, 11:4182-4190.
8. Liu Y, Perdreau SA, Chatterjee P, Wan L, Kuan, SF, Duensing A. Imatinib mesylate induces quiescence in gastrointestinal stromal tumor (GIST) cells through the CDH1-SKP2-p27Kip1 signaling axis. Cancer Research 2008, 68:9015-23.
9. Liu Y, Tseng M, Perdreau SA, Rossi F, Antonescu C, Besmer P, Fletcher JA, Duensing S, Duensing A. Histone H2AX is a mediator of gastrointestinal stromal tumor (GIST) cell apoptosis following treatment with imatinib mesylate. Cancer Research 2007; 67:2685-2692.
10. Liu Y, Parry JA, Chin A, Duensing S, Duensing A. Soluble histone H2AX is induced by DNA replication stress and sensitizes cells to undergo apoptosis. Molecular Cancer 2008; 7:61.
11. Bross PF, Kane R, Farrell AT, Abraham S, Benson K, Brower ME, Bradley S, Gobburu JV, Goheer A, Lee SL, Leighton J, Liang CY, Lostritto RT, McGuinn WD, Morse DE, Rahman A, Rosario LA, Verbois SL, Williams G, Wang YC, Pazdur R. Approval summary for bortezomib for injection in the treatment of multiple myeloma. Clin Cancer Res 2004, 10:3954- 3964.
12. Bauer S, Parry JA, Muhlenberg T, Brown MF, Seneviratne D, Chatterjee P, Chin A, Rubin BP, Kuan SF, Fletcher JA, Duensing S, Duensing A. Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cells. Cancer Res 2010, 70:150- 159.
13. Muhlenberg T, Zhang Y, Wagner AJ, Grabellus F, Bradner J, Taeger G, Lang H, Taguchi T, Schuler M, Fletcher JA, Bauer S. Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors. Cancer Res 2009, 69:6941- 6950.
14. Lonard DM, Nawaz Z, Smith CL, O’Malley BW. The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation. Mol Cell 2000, 5:939-948.
15. Duensing S, Duensing A. Bortezomib: Killing two birds with one stone in gastrointestinal stromal tumors. OncoTarget 2010, 1:6-8.


text:
A recent study sheds light on the potential benefits of physical activity in alleviating pain intensity among cancer survivors. Published in the peer-reviewed journal CANCER by Wiley online, the research, led by Erika Rees-Punia, PhD, MPH, from the American Cancer Society, and Christopher T.V. Swain, PhD, from the University of Melbourne, Australia, offers insights into the role of exercise in managing post-cancer pain.
While the positive effects of physical activity on various types of pain are well-documented, its specific impact on cancer-related pain has remained uncertain. To address this gap, the researchers analyzed data from 51,439 adults without a cancer history and 10,651 adults who had previously been diagnosed with cancer. Participants were asked to rate their average pain level on a scale from 0 (no pain) to 10 (worst imaginable pain), and to report their typical physical activity.
In line with U.S. guidelines recommending moderate-intensity aerobic activity for 150 to 300 minutes per week, or vigorous-intensity activity for 75 to 150 minutes per week, the study assessed participants’ adherence to these recommendations.
The findings revealed a significant association between increased physical activity and reduced pain intensity, regardless of participants’ cancer history. This suggests that exercise may play a role in mitigating cancer-related pain, akin to its effects on other types of pain.
Among individuals with a history of cancer, those surpassing physical activity guidelines were 16% less likely to report moderate-to-severe pain compared to those not meeting the guidelines. Additionally, individuals who maintained consistent physical activity or adopted it later in life reported lower levels of pain compared to those who remained inactive.
In summary, the study underscores the potential of physical activity as a non-pharmacological intervention for managing pain among cancer survivors. Further research is warranted to explore the mechanisms underlying this relationship and to optimize exercise-based interventions for improved pain management in this population.

domain: literature


text:
VIGO COUNTY, Ind. (WTHI) - On Tuesday, November 5 all Vigo County voters will have the chance to vote yes or no to two very important referendums.
On Tuesday, we took a look at the casino question.
Now, we will take a look at question number two. It involves the Vigo County School Corporation and tax dollars.
It is a long detailed question, so we wanted to break it down for you before you head into the voting booth.
Referendum number two will look like this on the ballot: For the eight calendar years immediately following the holding of the referendum, shall Vigo County School Corporation impose a property tax rate that does not exceed 16 and 22-hundredths cents on each $100 of assessed valuation and that is in addition to all other property taxes imposed by the school corporation for the purpose of funding safe transportation of students, to maintain safe and secure schools, reduce the class sizes and attract and retain teachers and staff for our children?
Now, let's break that down.
This is what's called an operational referendum.
The school corporation says it needs the money to operate day-to-day.
It would come strictly through property taxes and must stay in place for eight years.
And the addition is "Outside the state-mandated property tax cap."
So, everyone would pay. Homeowners, renters, commercial property owners, and agricultural property owners.
The taxpayer impact breaks down like this: If your home has a gross assessment value of $100,000, your yearly property taxes would go up a little more than $53.
That is about $4.50 more a month.
Superintendent Dr. Rob Haworth says if you vote yes to the referendum, it should bring $7 million into the corporation each year for eight years.
That money will go toward paying people inside the schools, first...for student protection.
"After Sandy Hook, the school district responded with placing student protection officers in every building. Multiples in junior highs or middle schools and high schools. We've grown our protection officers from eight to 38," Haworth said.
If the referendum is approved, $1.4 million a year will go to pay for school protection officers in every school.
— WTHI News10 (@WTHITV) October 16, 2019
Remember, there were only eight officers on staff in 2012.
$300,000 a year would go to pay behavior interventionists or guidance counselors.
18 counselors have been added to the corporation since 2015. A role that's evolved to help children with family and social issues.
"The school guidance counselors are doing more than just scheduling. They are trying to help children that may be broken in some way, so for the expense, it's over $5 million to pay for additional guidance counselors that have been added," Haworth said.
$3 million of the referendum would go to teacher compensation.
The hope is that money will help attract and keep good teachers in the corporation.
$260,000 would go to school nurses. The corporation has doubled the number of nurses on staff since 2015.
$1 million from the tax increase would be used on transportation. About 12,000 students use school buses every day.
Right now, the corporation s using its cash balance to pay for transportation.
Superintendent Haworth says if the referendum fails, there would likely be redistricting, school consolidation, or even some school closures to save money.
Right now, the corporation s looking closely at where cuts can be made.


President Maurice Paganello and the former President of Madrid were welcomed in the country, where they incorporated Al Jazeera into the racing project and organized the Peace Party
Morris Pagniello, President of Genoa International Academy and Jockey City Group versus Rubén De la Red. Former European Cup champions Espanyol and former Real Madrid joined a project that incorporated Al Jazeera Football Club (the country’s most important and historic club) in Jordan’s first division into other racing projects (Murcia, Sacramento and Karp) Here) there are other former Paladins, such as Morientes, Congo or Drenthe (Murcia Racing Star).
Both are received by members of the Royal Family, the Federal President and the Minister of Sports, whose vision is to promote the development of football in Jordan. These projects include the improvement of the quarry and the options for Asian men’s and women’s teams to come to Spain to improve their quality. In addition, they also closed the Peace Party, which will be held in Jordan on October 25. Several football legends will join the Peace Party.


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Officials from Kalyan’s Sacred Heart school, on Wednesday, January 11, 2023, staged a protest by sitting outside the school premises, on the road, in the pothole, demanding the road repair work to be expedited. A 14-year-old student from the school fell from the two-wheeler due to the pothole, eventually being injured severely. Reports state that the potholes have increased, and that the department has not taken steps to repair the same.
Owing to the troubles faced by the children, parents and the administration, the director of the school decided to sit in the waterlogged road thereby bring its condition to notice.
As per reports, the student fell on the NH-61 Kalyan Murbad route while returning from the baseball practice on Sunday. The parent and the child were on the two-wheeler which lost the balance after it skid on muddy road due to waterlogging.
Quoting the school administrator, Albin Antony, the report in Hindustan Times mentioned, “I had planned this sit-in on January 22, but after her mother told me about her son’s accident and expressed her concern over his safety, I decided to do it now. Tomorrow some major tragedy will take place. Before anything of that sort happens, we want the authority to act. In the last three days, I have mailed the authority several times, but there is no response from them.”
Questions have also been raised as the local body has not taken enough steps to repair the roads and the locals have now demanded the concretisation work to be expedited. Reports state that over three-kilometres,s on NH61, is in poor condition. Similar protests were staged last year too whereby traffic congestion was the issue and students had to walk to the institute.
Responding to the matter, NHAI official informed that the work in the mentioned stretch is underway and notice has been issued to the contractor to complete the work at the earliest. The department is expecting the same to be finished by April 2023.