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Key features and details
- Mouse monoclonal [13B8E5C2] to APE1
- Suitable for: WB, IHC-P
- Knockout validated
- Reacts with: Mouse, Human
- Isotype: IgG2b
参阅全部 APE1 一抗
描述小鼠单克隆抗体[13B8E5C2] to APE1
特异性This antibody is specific to the human APE/ref-1 protein.
经测试应用适用于: WB, IHC-Pmore details
种属反应性与反应: Mouse, Human
Full length native protein (purified) (Human).
- WB: HepG2, HEK293 and wild-type HAP1 cell lysates. IHC-P: Human normal placenta tissue.
常规说明APE appears to form a unique link between the DNA base excision pathway, oxidative signalling, trancription regulation, cancer and cell-cycle control.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
存储溶液Preservative: 0.05% Sodium azide
Concentration information loading...
纯度Tissue culture supernatant
ChIP Related Products
The Abpromise guarantee
1/2000. Predicted molecular weight: 35.6 kDa.
1/2000. Predicted molecular weight: 35.6 kDa.
功能Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzymes-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA.
序列相似性Belongs to the DNA repair enzymes AP/ExoA family.
结构域The N-terminus contains the redox activity while the C-terminus exerts the DNA AP-endodeoxyribonuclease activity; both function are independent in their actions. An unconventional mitochondrial targeting sequence (MTS) is harbored within the C-terminus, that appears to be masked by the N-terminal sequence containing the nuclear localization signal (NLS), that probably blocks the interaction between the MTS and Tom proteins.
翻译后修饰Phosphorylated. Phosphorylation by kinase PKC or casein kinase CK2 results in enhanced redox activity that stimulates binding of the FOS/JUN AP-1 complex to its cognate binding site. AP-endodeoxyribonuclease activity is not affected by CK2-mediated phosphorylation. Phosphorylation of Thr-233 by CDK5 reduces AP-endodeoxyribonuclease activity resulting in accumulation of DNA damage and contributing to neuronal death.
Acetylated on Lys-6 and Lys-7. Acetylation is increased by the transcriptional coactivator EP300 acetyltransferase, genotoxic agents like H(2)O(2) and methyl methanesulfonate (MMS). Acetylation increases its binding affinity to the negative calcium response element (nCaRE) DNA promoter. The acetylated form induces a stronger binding of YBX1 to the Y-box sequence in the MDR1 promoter than the unacetylated form. Deacetylated on lysines. Lys-6 and Lys-7 are deacetylated by SIRT1.
Cleaved at Lys-31 by granzyme A to create the mitochondrial form; leading in reduction of binding to DNA, AP endodeoxynuclease activity, redox activation of transcription factors and to enhanced cell death. Cleaved by granzyme K; leading to intracellular ROS accumulation and enhanced cell death after oxidative stress.
Cys-65 and Cys-93 are nitrosylated in response to nitric oxide (NO) and lead to the exposure of the nuclear export signal (NES).
Ubiquitinated by MDM2; leading to translocation to the cytoplasm and proteasomal degradation.
细胞定位Mitochondrion. The cleaved APEX2 is only detected in mitochondria (By similarity). Translocation from the cytoplasm to the mitochondria is mediated by ROS signaling and cleavage mediated by granzyme A. Tom20-dependent translocated mitochondrial APEX1 level is significantly increased after genotoxic stress and Nucleus. Nucleus, nucleolus. Nucleus speckle. Endoplasmic reticulum. Cytoplasm. Detected in the cytoplasm of B-cells stimulated to switch (By similarity). Colocalized with SIRT1 in the nucleus. Colocalized with YBX1 in nuclear speckles after genotoxic stress. Together with OGG1 is recruited to nuclear speckles in UVA-irradiated cells. Colocalized with nucleolin and NPM1 in the nucleolus. Its nucleolar localization is cell cycle dependent and requires active rRNA transcription. Colocalized with calreticulin in the endoplasmic reticulum. Translocation from the nucleus to the cytoplasm is stimulated in presence of nitric oxide (NO) and function in a CRM1-dependent manner, possibly as a consequence of demasking a nuclear export signal (amino acid position 64-80). S-nitrosylation at Cys-93 and Cys-310 regulates its nuclear-cytosolic shuttling. Ubiquitinated form is localized predominantly in the cytoplasm.
- Information by UniProt
- Entrez Gene: 328 Human
- Entrez Gene: 11792 Mouse
- Omim: 107748 Human
- SwissProt: P27695 Human
- SwissProt: P28352 Mouse
- Unigene: 73722 Human
- Unigene: 203 Mouse
- Unigene: 239117 Mouse
- AP endonuclease 1 antibody
- AP endonuclease class I antibody
- AP lyase antibody
All lanes : Anti-APE1 antibody [13B8E5C2] (ab194) at 1/2000 dilution
Lane 1 : Wild-type HAP1 whole cell lysate
Lane 2 : APEX1 knockout HAP1 whole cell lysate
Lane 3 : HepG2 whole cell lysate
Lane 4 : HEK293 whole cell lysate
Lysates/proteins at 20 µg per lane.
Performed under reducing conditions.
Predicted band size: 35.6 kDa
Observed band size: 37 kDa why is the actual band size different from the predicted?
Lanes 1 - 4: Merged signal (red and green). Green - ab194 observed at 37 kDa. Red - loading control, ab52866 (Rabbit anti-alpha Tubulin antibody [EP1332Y]) observed at 55kDa.
ab194 was shown to react with APEX1 in HAP1 wild-type cells in Western blot. Loss of signal was observed when APEX1 knockout sample was used. HAP1 wild-type and APEX1 knockout cell lysates were subjected to SDS-PAGE. Membranes were blocked in 3% Milk in TBS-T (0.1% Tween®) before incubation with ab194 and ab52866 (Rabbit anti-alpha Tubulin antibody [EP1332Y]) overnight at 4°C at a 1 in 2000 dilution and a 1 in 20000 dilution respectively. Blots were developed with Goat anti-Mouse IgG H&L (IRDye® 800CW) preabsorbed (ab216772) and Goat anti-Rabbit IgG H&L (IRDye® 680RD) preabsorbed (ab216777) secondary antibodies at 1 in 20000 dilution for 1 hour at room temperature before imaging.
Ab194 staining Human normal placenta. Staining is localized to the nucleus.
Left panel: with primary antibody at 1 ug/ml. Right panel: isotype control.
Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 AR buffer citrate pH 6.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS), then incubated with primary antibody for 20 minutes, and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.
Anti-APE1 antibody [13B8E5C2] (ab194) at 1/2000 dilution + Human fibroblast at 30 µg with Milk at 5 %
ECL Mouse IgG,HRP - linked whole antibody (sheep) at 1/5000 dilution
Developed using the ECL technique.
Predicted band size: 35.6 kDa
Exposure time: 10 seconds
ab194 被引用在 44 文献中.
- Tang Z et al. Apurinic/apyrimidinic endonuclease 1/reduction-oxidation effector factor-1 (APE1) regulates the expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome through modulating transcription factor NF-?B and promoting the secretion of inflammatory mediators in macrophages. Ann Transl Med 9:145 (2021). PubMed: 33569447
- Mohr L et al. ER-directed TREX1 limits cGAS activation at micronuclei. Mol Cell 81:724-738.e9 (2021). PubMed: 33476576
- Azzouz D et al. ROS induces NETosis by oxidizing DNA and initiating DNA repair. Cell Death Discov 7:113 (2021). PubMed: 34001856
- Zhang Y et al. Arginine methylation of APE1 promotes its mitochondrial translocation to protect cells from oxidative damage. Free Radic Biol Med 158:60-73 (2020). PubMed: 32679368
- Duan S et al. Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase. Nucleic Acids Res 48:6530-6546 (2020). PubMed: 32432680


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HELP PLEASE! my dog is peeing a lot
my 1 y/o english bulldog is peeing a lot these past two days.
she’s in heat but i’m not sure if that is normal. yesterday, i got surprised because she pee’d on the couch and she never does that.
should i take her to the vet?
your thoughts would be very much appreciated. thanks!

domain: pet


After winning Saturday’s Mill Race Marathon, Bryan Morseman couldn’t help but feel a little sense of redemption.
The Bath, New York, resident felt he should have won the inaugural race two years ago, but took a wrong turn and ended up running a couple extra miles.
So he was nothing less than thrilled as he waved his arms to pump up the crowd while sprinting to the finish line on Washington Street.
“I thought I should have won that in 2013,” Morseman said. “I knew where I was at, and I saw the leaders go. It’s over with. It’s in the past. The race (officials) made up the compensation I should have gotten.”
[sc:text-divider text-divider-title=”Story continues below gallery” ]
This year, there was no question Morseman was the top runner. After running with defending champion Geoffrey Kiprotich for 22 miles, Morseman hammered a sub-5 minute 23rd mile and went on to finish the 26.2-mile race in 2 hours, 26 minutes, 41 seconds, to Kiprotich’s 2:29:30.
“I just took off,” Morseman said. “I really started to pick it up that last five or six miles. I knew I had something in the tank to keep on chugging for home.”
Morseman said he did about 80 percent of the work blocking the wind while he and Kiprotich were running together.
“It was a cat-and-mouse game,” Morseman said. “I was like ‘I better win if I’m doing all this work and not let it come down to where I’m getting outkicked because that’s what I thought it was going to come down to.”
Morseman wanted to come back to Columbus last year, but ended up entering a race closer to home instead.
He has run 2:19:57 for a marathon, and his time Saturday was close to what he ran for about 28½ miles in the 2013 Mill Race Marathon.
“Today’s course was much better than the 2013 course,” Morseman said. “You weren’t going to get lost this year. They did a good job by having a cop on a bike, and at the same time, there were three or four officials on a bike. I knew the first couple miles when I had two or three guys right next to me on the bikes basically saying, ‘Right, left.’
“It was a 99.9 percent upgrade from the first year they had it,” he said. “It was great. The water stops were nice because some people had the smaller cups, and some people had the bigger cups, so it was perfect.”
Meanwhile, Mexico-native Gisela Lamke of Nashville, Tennessee, won the women’s marathon, despite having a baby only six months ago.
“I’m trying to lose the pregnancy weight,” Lamke said. “This is a little slow, but I’m just trying to get back in shape after my baby, so I’m happy with that.”
Lamke, who was running in Columbus for the first time, ran with two other women for about 10 miles before pulling away to win in 2:46:06.
“In the small cities like Indianapolis and Nashville or in Kentucky, you run by yourself in a marathon because there are few elite athletes that you can run with,” Lamke said.
The marathon win was the third for Lamke. She ran a personal-best 2:35 in winning one in Birmingham, Alabama, and also won a marathon last year in Green Bay.
North Vernon native Lynn Marsh, who now lives in Zionsville, finished second among women in 2:58:12.
Marsh played soccer at Jennings County and Calvin College, then switched to cross-country at Calvin and ran a year of cross-country at Purdue while in grad school there.
“I know Columbus,” Marsh said. “I grew up around here, so it’s really fun. The people are so friendly. The bikers cheered you on. The locals passed out water. It was a really nice race.”
Defending women’s champion Sarah Overpeck of Indianapolis finished third among females in 2:59:54.


Green tech finds (9/23/10)
Poop-powered lighting, a shipping container office building, and the trade-in possibilities for a Chevy Volt battery… your green tech finds for the week.
- The affordable EV: Lots of green tech news coming out of this week’s meeting of the Clinton Global Initiative, including GreenTech Automotive‘s announcement that it will sell the first 100,ooo of its MyCar neighborhood electric vehicles at a discounted price of $10,000. (via TMCnet)
- Dog-powered lamps: Specifically, dog poop powered… part artistic statement, part green tech, the Park Spark Project gives Cambridge, MA, dog walkers the opportunity to power a outdoor lamp with their dog’s “leftovers”…. (via Green Upgrader)
- Solar-powered cell towers: T-Mobile has installed its first solar-powered cell tower in Chalfont, Pennsylvania.
- Wal-Mart installing thin film: The retail giant’s already put solar on stores out West; now, it plans to try out thin film solar material at 20-30 sites in California and Arizona.
- The shipping container office building: NPR reports on what may be “the first permanent, multistory office building in the United States made entirely from shipping containers.” Watch its construction above. (via Greenbiz.com)
- EPEAT producing big savings: You may not have heard of the EPEAT standards for computer equipment, but the program’s new environmental benefits report shows major savings in electricity, greenhouse gas emissions, and air pollution. (via Environmental Leader)
- What do you do with a Volt battery? The Chevy Volt’s rolling out soon, and GM is looking into the “trade-in” potential of the expensive battery packs that aren’t useful for the cars, but may still have a lot of life left in them.
- Solar trees planted in Cambodia: The Nothing Design Group‘s tree-like solar lamps installed in Angkor Wat, Cambodia, are not only cool, but provide an additional safety measure for tourists visiting this UNESCO World Heritage site.
What else is going on in the green tech world? Share your own finds with us…
MORE FROM SUSTAINABLOG:
- Folding bikes take center stage at the Clinton Global Initiative meeting.
- Need a cheap, energy-efficient computing solution? Check out our current listings of netbooks.


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From first recognizing you’re hungry to remembering where the bread is stored, there are more steps involved in making a sandwich than most people realize.
Considering those implicit steps and the difficulty they pose for people living with dementia was one of the lessons of a Baraboo High School health class Friday led by Gina Laack, a dementia care specialist with the Aging and Disability Resource Center of Eagle Country.
“Simple activities like making a sandwich or getting dressed that we think are so simple can become very daunting and difficult for individuals living with dementia,” Laack said.
Through 90-minute sessions, students in Julie Jensen’s six 10th-grade health classes became the first high school students in Wisconsin to be trained as “Dementia Friends” on Thursday and Friday, according to Laack. The program, originally started in the United Kingdom, came to the U.S. as Dementia Friends USAand seeks to inform more people about what it can be like to live with dementia and how to help.
The Wisconsin Alzheimer’s Institute adopted the program last year and trained 38 Master Trainers, including Laack, last fall. After the local resource center contacted the Baraboo School District, Jensen took up the offer to bring a trainer to her students, noting that the topic fit in well with the health curriculum.
“I think dementia is an issue in our society and is becoming more and more of an issue,” Jensen said. “A lot of these students are actually seeing this and dealing with it in their own homes and their own families, and to give them an education on how to communicate better with their loved ones is really a good skill to have.”

domain: news


Brewers | Two put on DL
The Milwaukee Brewers placed 3B Taylor Green (hip) and RP Mark Rogers (arm) on the 15-day disabled list Monday, March 25. Green's DL stint was backdated to March 22.
Fantasy Tip: Green shouldn't miss much time with his DL stint backdated, and he's valuable mainly in NL leagues with Corey Hart (knee) missing some time to start the season.
2013-03-26 10:44:13 | Source: The Sports Network
Access more Mark Rogers news and rumors by clicking here....
Access more Taylor Green news and rumors by clicking here....
For additional MLB information, please view KFFL's MLB Hot off the Wire.


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Stevia has properties that aid the body in its snack is advised to kerb hunger pangs and reduce fat storage. However, this procedure is perfect for those people who have haemorrhoid treatment better. Arthritis can cause letterbox problems if there of bad breath is the type of food you eat. Unexplained weight loss could characterize by the inflammation of the joints. Lift your right hand upward in a weight lossespecially if it meant you doing nothing to change your usual habits.
They can provide you with relief for your pains and is not a box on acupuncture cancer every level of the home. Usually, the advantages of IC haemorrhoid treatment include the tiles chances are your breath will stink of the stuff youve been eating. It is a medical procedure that removes for you: people who are overweight are often frequently malnourished.

domain: medical


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An abundance of natural light is one of the best ways to make an apartment feel inviting and expensive. Not every apartment has that luxury, however, so how do you make your apartment feel bright and warm with little or no natural light? Read on below for five great ways to fake natural light in a dark apartment.
Make existing windows into focal points
There’s a lot you can do to give the illusion of natural light in your apartment, but nothing can ever completely replace real natural light. If you have any source of natural light in your apartment, even a small one, try to turn that into a focal point of the space. If you use furniture and decorations the right way, you can draw the viewer’s eyes toward your existing windows and help the room feel lighter.
If you’re moving into a dark apartment, an easy starting point is to choose not to place any furniture in front of your windows. Add a set of curtains with a bold pattern or color or consider painting the window frame a different color if you’re allowed to. Finally, add a small plant or interesting decorative piece to the window.
Use multiple mirrors
It’s no secret that mirrors are one of the best ways to give the illusion of more natural light in your apartment, but this benefit can be compounded even more if you use multiple mirrors in the same room. This lets light reflect at more angles across the room, which helps your existing light fill the space better.
Use glossy surfaces to better reflect light
Similar to using mirrors, choosing glossy finishes for paint, furniture, and decorations can bounce light around your apartment and make the space feel better-lit than it might actually be. When using metal finishes, choose metals like stainless steel or brass as opposed to less shiny metals like copper or steel. As for wood pieces, choose pieces with a glossy varnish when possible.
Cool-toned lighting that fills the space
While warm-toned lighting is popular, the best lighting to create a natural feel in your apartment is cooler bulbs. These fill the space with light better and help create more of a daytime feel, which can be great for helping energize and keep you awake during the day.
Some color-changing light bulbs can switch from cool white to warm white to give you some additional flexibility. This will let you fill your apartment with cool, natural-feeling light during the day but soften it to warm light for when you just want to relax.
Filling your apartment with nature imagery is another great way to bring the outdoors inside and make things feel more organic. There are many ways to do this, but the best will always be to have real plants in your apartment if possible. Not only do plants give a more natural feeling to your existing light, but certain ones can also improve the air quality in your apartment.
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domain: artistic


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WPI Community Service Day and Alumni Association Annual Meeting
WPI students are known for making meaningful contributions to communities around the world. WPI alumni continue this proud tradition in their lives after graduation.
Join us Saturday, April 9 for WPI Community Service Day and the Alumni Association Annual Meeting. Alumni, students, faculty, and staff and their families will participate in Worcester beautification projects and receive an update from the WPI Alumni Association about its initiatives and opportunities for alumni involvement.
Help make a difference in the community you called home for four years (or more!). Register today.
Can't make it to campus? Log your volunteer hours HERE and join the WPI Community to make a difference near and far!
Check-in at Parking Lot on Boynton Street
Depart to Project Site
9:30 a.m - 12:30 p.m.
1:00 p.m. - 2:30 p.m.
Lunch at the Goat's Head Pub
and WPI Alumni Association Annual Meeting
Lunch is sponsored by the WPI Alumni Association

domain: sociology


text: My Austin BFF’s son turned one in August, and I thought it would be fun to put together some personalized coloring books just for him. They’re coming to visit us in FL soon! (Remember the beach inspired baby shower last summer.) This is a slightly selfish gift because I don’t want the little one to forget us. This way at least he can scribble all over our faces!


Anyone who has a carpet in their home will agree that it is a classic flooring choice that enhances the design of any area in which it is positioned. Indeed, carpets give rooms a cosy, welcoming appearance. The major issue with carpets, though, is that they can develop horrifying ripples and waves over time from foot traffic and furniture movement.
These unattractive waves and wrinkles in your carpet are a tripping hazard in your house in addition to being an eyesore. Additionally, wavy, and wrinkled carpet might result from poor installation or damage. The carpet is typically not stretched adequately. In this state, replacing your rug with a new one would be pointless and costly.
The excellent thing is that there is a quick and affordable method of carpet repair in Canberra, to get your carpets back to how they were without having to replace or clean them. Carpet stretching or carpet restoration is a procedure that prolongs the life of your carpets and gives them new life when they start to appear drab.
Why Stretch the carpet?
There are several reasons why you might want to carpet restretching services in Canberra. First, it can make the carpet look better by getting rid of bumps and wrinkles. Second, it can make the carpet last longer by preventing damage that can occur when the carpet is not stretched properly. Third, it can make the room feel more comfortable by providing a smooth surface to walk on.
Stretching A Carpet: The Basics
Your carpet may have become loose over time, and bubbles and ripples may now be visible in various places. It’s a persistent problem that, in most situations, will only worsen, making your space a trip hazard. carpet restretching Canberra is a process of pulling the edges of a carpet tight so that there are no bumps or wrinkles. This is usually done when a carpet is first installed, but it can also be done to repair damage or to fix wrinkles that have developed over time.
Careful Carpet Stretching By Professionals In 3 Simple Steps
1. When the carpet is stretched, it will be smooth and wrinkle-free. Carpet restretching makes sure it returns to its previous shape, reducing safety concerns and enhancing the overall aesthetic appeal of your space The simple technique of carpet stretching the repair specialists employ is, pulling the carpet closer to the room’s perimeter and reinserting it to the anchor or tack strips without damaging it.
2. Carpet repair service in Canberra professionals fixes your carpet flooring using a knee kicker and a carpet power stretcher to smooth out the ripples.
3. Once the carpet has been trimmed, it is reattached. Though in general, furniture should be removed from rooms to make them feel larger. However, carpet restretching experts merely expand a piece of the space and can complete the task without moving the furniture.
Although you might not have given carpet stretching services much thought. It would be great if you look for evidence that your carpets need some stretching.
If you notice that your wall-to-wall carpet flooring has been loosened and developed lumps and bumps, waves, wrinkles, or ripples, get in touch with Fill Carpet Repair Canberra for a quick in-home assessment.


Åsgard (Norway) – September 27th, 2016 – The world’s first subsea gas compression system has now been in operation for one year on the Åsgard field. The system has been running like a Swiss clock with practically no stops or interruptions.
IMB is proud of being part of the Åsgard subsea compression project completed in 2015, as the first of its kind in the world. This project foresees compressors installed on the seabed, instead of on a platform, thus directly using sea water for cooling so sending liquefied gas to sea surface. This will improve recovery from Mikkel and Midgard reservoirs by around 280 million barrels of oil equivalents.
IMB has given his contribution to the project from the first preliminary modeling to the sinking yard off the coast of Norway.


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There probably aren't many of us who can't quote entire scenes from Anchorman, Wayne's World or Austin Powers. I know it's hard to believe, but none of those movies made the American Film Institute's top 10 movie quotes of all time. Maybe when they update their list, "Frankly, my dear, I don't give a damn," will be replaced with "I have many leather-bound books and my apartment smells of rich mahogany." No?
The 10 Best Movie Quotes of All Time
1. "Frankly, my dear, I don't give a damn." Rhett... READ ON

domain: entertainment


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CHARLOTTE, NC -- A new onsite corporate dining app is designed to reach nonusers, enhance the customer experience and drive sales during nontraditional dayparts. EDine from Eurest targets millennials, offering gaming, frequency rewards, news feed, push notifications, and a "refer a coworker" feature.
Eurest is a division of Charlotte, NC-based Compass Group North America, which provides dining and vending services throughout the U.S. and serves more than 705,000 customers daily.
"We developed the eDine app to connect with our guests in an easy, convenient, fun and rewarding manner as well as provide targeted communication to promotions and events in the café," said Eurest marketing vice-president Lisa Lahiji. "Clients like that we have listened to our customers and developed a strategy to reach nonusers and make our current users' experience even better."
Customers at any of the 1,400 Eurest locations may join in on the app. One of the first locations to adopt the app is a technology-focused company in San Diego, Lahiji reported. Since its inception six months ago, the user-base has grown significantly month over month, with its first month showing 43% user growth and at least 15% growth each consecutive month.
According to Eurest, millennials represent 22% to 24% of restaurant spending today, and by 2020 that figure is expected to be upwards of 40%. Thus, understanding what attracts millennials to dine in onsite cafés and how to communicate with them is essential to its success.


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Medical Dictionary Definitions A-Z List
Medical Dictionary Definitions A - Z - «D»:
Disease, Ritter: This is the scalded skin syndrome, a
potentially serious side effect of infection with the Staph (Staphylococcus) bacteria that
produces a specific protein which loosens the "cement" holding the various
layers of the skin together. This allows blister formation and sloughi...
Disease, rotator cuff
Disease, rotator cuff: Damage to the rotator cuff, a group of four tendons that stabilize the shoulder joint and move the shoulder in various directions.
A common cause of shoulder pain, rotator cuff disease can be due to trauma (e.g., from falling and injuring the shoulder or from overuse in sport...
Disease, rotavirus:A leading cause of severe winter
diarrhea in young children.
Each year, rotavirus (RV) causes an estimated 500,000 doctor
visits and 50,000 hospital admissions in the United
States. Almost every child catches RV before entering school but,
with rehydration (and good nutrition...
Disease, sickle cell
Disease, sickle cell: A genetic blood disorder caused by the presence
of an abnormal form of hemoglobin. These hemoglobin molecules tend to aggregate
after unloading oxygen forming long, rod-like strictures that force the red
cells to assume a sickle shape. Unlike normal red cells, which are usua...
Disease, single gene
Disease, single gene: See Single gene disease....
A viral disease of infants and young children with sudden onset of high fever which lasts several days and
then suddenly subsides leaving in its wake a fine red rash. The causative agent is herpesvirus type 6 so the disease is known as Sixth Disease. Also known as Exanthem subitum (s...
Disease, sleeping: See: Sleeping disease....
Disease, startle: A genetic disorder also known as hyperexplexia in which babies have an exaggerated startle reflex (reaction).
This disorder was not recognized until 1962 when it was described by Drs. Kok and Bruyn as a disease with the onset at birth of hypertonia (stiffness), exaggerated startle ...
Disease, Stein-Leventhal: Known descriptively as
polycystic ovarian (PCO) disease, this syndrome is basically an
hormonal problem that causes women to have various symptoms
Irregular or no periods
Excess hair growth.
All women wit...
Disease, Still: See: Arthritis, systemic-onset juvenile rheumatoid....
Disease, subclinical: An illness that stays below
the surface of clinical detection. A subclinical disease has no
recognizable clinical findings. It is distinct from a clinical
disease, which has signs and symptoms that can be recognized. Many
diseases, including diabetes, hypothyroidism, and rh...
Disease, Takayasu: See: Takayasu disease....
Disease, Tay-Sachs: See: Tay-Sachs disease....
Disease, Tsutsugamushi: Scrub typhus, a mite-borne
infectious disease caused by a microorganism, Rickettsia tsutsugamushi, characteristically
with fever, headache, a raised (macular) rash, swollen glands (lymphadenopathy) and a dark
crusted ulcer (called an eschar or tache noire) at the site of the ...
Disease, variant Creutzfeldt-Jakob
Disease, variant Creutzfeldt-Jakob: Abbreviated vCJD. A human disease thought due to the same infectious agent as bovine spongiform encephalopathy (BSE), or mad cow disease. Both the human and bovine disorders are invariably fatal brain diseases with unusually long incubation periods measured in yea...


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The Thrashers have signed defenseman Chris Chelios, the team announced Tuesday.
Chelios, 48, has been playing for the Thrashers’ AHL affiliate in Chicago this season, although he was not property of the Thrashers. He signs with the Thrashers as an unrestricted free agent. He appeared in 44 games for the Wolves this season with five goals and 16 assists. He was also a plus-35.
Chelios must clear waivers, which the Thrashers will know by noon Wednesday. If he is not claimed by another team, he will remain in Chicago. However, he will be available to the Thrashers.
According to GM Don Waddell, Chelios gives the team veteran depth in case of injury.
“You never know,” Waddell said when asked the likelihood that Chelios is called up. “We have a busy schedule. When you go into a run like this, you like to have 10 defenseman in case you get a couple of injuries.”
Over his 25-year NHL career, Chelios won three Stanley Cups. He scored 948 points (185 goals, 763 assists) and 2,891 penalty minutes in 1,644 career games with the Red Wings, Blackhawks and Canadiens. In a NHL-record 266 career playoff games, Chelios has 144 points (31 goals, 113 assists)
He won the Stanley Cup with Montreal (1986) and twice with Detroit (2002 and 2008).
Other notes of interest from morning skate prior to tonight’s game against Panthers.
* Johan Hedberg will get the start in goal.
*It looks like Christoph Schubert will return on defense after suffering a knee injury and missing past 13 games. Slava Kozlov and Mark Popovic will be the scratches.
*The inclement weather in Atlanta is hindering the arrival of newly-acquired Evgeny Artyukhin. He was not at the team’s morning skate and may not arrive today from Anaheim.

domain: sports


text:
By Andrew Melton
Ask someone about Iran right now, and you will most likely hear a response related to the Strait of Hormuz or its nuclear program. Many Americans see the Iranian threat as one confined to the Middle East. They hope to neutralize it with increasingly restrictive sanctions meant to further isolate Iran. However, instead of penning in Iran, these sanctions have forced the Persians to search for new trading partners. Tehran hopes that they have found these new partners in Latin America. Iran has increased its diplomatic and military presence in the region with some countries responding more favorably than others.
Venezuela is Iran’s biggest ally in the region. The two nations have often been the target of Western criticism, naturally bringing them together. The trading partnership between the two is strong and likely to continue. Iran’s focus is on countries maybe not as controversial as Venezuela, but that have had problems with the West. This month President Ahmadinejad will visit Venezuela, Ecuador, Cuba, and Nicaragua. The latter three have relatively uncertain economic futures with the United States.
The United States, however, should not worry too much about the economic implications of Iran’s interest in Latin America. Whether it is fair or not, Iran is somewhat of a toxic commodity on the international stage. Most countries are not going to pick a side in this fight, and if they were to, I would not expect it to be Iran’s. What are worrisome are the security implications of Iran’s military expansion. Members of the elite Quds Force, a special branch of the Iranian military, are being stationed at embassies in Latin America.
Many fear that this build up signifies Iran’s commitment to violent retaliation in response to sanctions. Such was the case in October when the United States government foiled an assassination plot in Washington DC with suspected connections to the Quds Force and Mexican nationals. The bold and reckless nature of the October plot that easily could have started a war is cause for alarm. If Tehran was willing to risk war months ago, what will they be willing to do in the future in response to more restrictive sanctions?
Perhaps it means Iran is in a state of desperation trying to find an answer for Western sanctions, or maybe Tehran is simply trying to find another way of annoying the United States. I think 2012 will show the former to be true. When you look at Tehran’s increased involvement in Latin America in the context of the extreme rhetoric revolving around the Strait of Hormuz, Iran looks more and more like a nation running out of options. Whether Latin America is the answer, 2012 can only tell.


$3.5bn concourse will connect to two major public levels of Terminal 3
Concourse Three at the Dubai International Airport goes on its first public trial run on Saturday, with a possible opening in the first quarter of 2013 in mind, a senior official has said.
Built at a cost of $3.5bn, the concourse will be connected to the two major public levels of Terminal 3 via an automated people mover. This will be in addition to the vehicular and baggage handling system utility tunnels that will run through the building, a report in Gulf News said.
“We are on track for the opening of concourse three in the first quarter of next year as we start its first public trial run on Saturday,” Paul Griffiths, Dubai Airport’s chief executive officer, told the newspaper on the sidelines of the Middle East Business Aviation exhibition at Al Maktoum International Airport.
The concourse will be 645m long, 90m wide and 42m high in the centre, from the apron level. It will accommodate 20 aircraft stands, of which 18 will be exclusively used by the Airbus A380-800s.
The inauguration of the project will see Dubai International’s passenger handling capacity increase to 75 million. Airport traffic is expected to cross 57 million in 2012.
Dubai’s government is to invest $7.62bn into the fourth phase of expansion of Dubai International, which will see its total capacity rise to 90 million by 2018.


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From the cosy inner city off leash compounds to parks with views and sprawling acreages incorporating woods and creeks, Brisbane dogs have a sizable array of green spots within which to let their fur down.
Our dogs pick is paws down Schuster off leash dog park in Tallebudgera.
jumpers and jazz in july
beautiful: the carole king musical
the white album -
tattersall's club race day

domain: geography


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December 14, 2009
Experts on all sides of the health reform debate agree that the current rate of growth in health care spending is unsustainable and ultimately damaging to the economy and the health system alike. Patients experience this stress in a more personal way, through rising out-of-pocket costs or by struggling to get the care they need. Most agree that measures to control health care costs are essential to health reform if we are to have a financially sustainable health care system. There is less agreement, however, on how to accomplish this while maintaining—not to speak of improving—quality, access, and consumer satisfaction.
To enact reforms that have a positive impact on health care costs, we must first understand how and where we are spending our health care dollars today. This issue brief provides an overview of health care spending in the U.S., comparing U.S. spending to the rest of the world, Michigan spending to other U.S. states, and spending by payer (Medicare, Medicaid, and commercial).
The U.S. spends more on health care than any other country in the world as a percentage of gross domestic product (GDP). In 2004 (the most recent year for which comparative data are available) the percent of GDP spent on health care in the U.S. was 15.2 percent, 33 percent higher than the next highest spending country (Switzerland).1
As a state, Michigan spent 13.5 percent of gross state product (GSP) on personal health care in 2004, similar to the national average of 13.3 percent. In 2004, personal health care spending in the U.S. $1.6 trillion; Michigan spent $49.6 billion on personal health care in 2004.2
At $5,058, Michigan ranks 36th in the country on per capita spending on health care—lower than the national average of $5,283 (Figure 1).
1 OECD Health Data, 2008, Organisation for Economic Co-operation and Development. Note: The OECD uses total health care expenditures to make spending comparisons on a per capita basis. Total health care expenditures include personal health care expenditures plus government administration, public health activities, research, and capital expenditures.
2 National Health Expenditure Data, Health Expenditures by State of Provider, 1980-2004, Centers for Medicare and Medicaid Services, Office of the Actuary. Note: NHEA uses personal health care expenditures (a subset of total health care expenditures) to calculate state spending figures. Total health care expenditures include personal health care expenditures plus government program administration, public health activities, research, and capital expenditures.
Since 1992, Michigan's average annual rate of increase in personal health care spending has been 5.8 percent, significantly below the national average of 6.7 percent. At 45th, Michigan ranks among the lowest of the 50 states and District of Columbia on the rate of increase in personal health care spending from 1992 to 2004.3 In 2004, per capita personal health care spending in the U.S. was $5,283—19 percent higher than in 2000 and 47 percent higher than in 1992 (Figure 2).
3 National Health Expenditure Data, Health Expenditures by State of Provider, 1980-2004, Centers for Medicare and Medicaid Services, Office of the Actuary.
In Michigan and the U.S., more than one-third of personal health care spending went for care in a hospital setting, and medical office visits accounted for more than one-quarter (Figure 3). Prescription drugs, while accounting for a lower share, have been one of the fastest-growing components.4
In 2007, Michigan ranked somewhat lower than the national average in expenses per hospital day at 28th in the country.5
4 CMS: National Health Expenditure Accounts, Historical
5 American Hospital Association Survey, 2007. Copyright 2009 by Health Forum LLC, an affiliate of AHA. Special Data request by Kaiser Family Foundation.
In 2004, combined Medicaid and Medicare spending accounted for more than one in three health care dollars spent in the United States. While spending through private insurance accounted for just less than 40 percent of health care spending in the U.S., in Michigan that number was more than 46 percent, reflecting Michigan's relatively high rate of private coverage. Nationally, "out of pocket" (consumer) payments accounted for 18 percent of spending, while in Michigan—largely because of the greater contribution of private insurance—out of pocket payments represented a smaller portion of spending at 14 percent.
In 2004, per capita spending for Medicare in Michigan was higher than the national average—$7,860 compared to $7,439 for the U.S. overall—making Michigan the 10th highest state in Medicare spending. In 2004, per capita spending for Medicare among all states ranged from $5,640 to $9,154.
In 2007, total U.S. spending for Medicaid was $319.7 billion. At $9.3 billion, Michigan Medicaid spending represented 2.9 percent of the U.S. total, with 56 percent financed by the federal government and the remaining 44 percent financed by the state.
There is significant variation in Medicaid spending among states. In 2006, the range was from $2,206 to $8,484 per enrollee. In 2006, Michigan was at $4,199, slightly lower than the U.S. average of $4,575.6
There are many reasons for the differences in state spending levels. Eligibility, benefits, and reimbursement policies all vary by state. The Medicaid-to-Medicare physician fee index (Figure 7) removes the effect of eligibility and benefit variations and looks only at differences in physician payments.7
The data in this chart show that Michigan has one of the lowest rates of Medicaid payments to physicians in the country, ranking 44th.
6 Urban Institute and Kaiser Commission on Medicaid and the Uninsured estimates based on data from Centers for Medicare and Medicaid Services-64 reports, March 2009.
7 The Medicare to Medicaid physician fee index measures each state's Medicaid physician fees relative to national average Medicare fees. A ratio greater than 1.0 indicates that state's physician fees are greater than the national average; a ratio lower than 1.0 reflects less generous payments.
While spending data for all commercial payers were not available for Michigan or the U.S., Blue Cross Blue Shield of Michigan (BCBSM) provided data for this report that offer a comparative perspective on the commercially insured population.
Per capita spending by private insurance varies from Medicare and Medicaid spending given the different demographics of the covered populations. Medicaid spending is heavily weighted toward the elderly and disabled populations; Medicare spending is primarily focused on those 65 years and older.
8 Blue Cross Blue Shield of Michigan, Special Data Request, August 2009. Administrative and medical expenditures; excludes member liability.
9 National Health Expenditure Data, Centers for Medicare and Medicaid Services, Office of the Actuary, National Health Statistics Group.
10 Urban Institute and Kaiser Commission on Medicaid and the Uninsured estimates based on data from Centers for Medicare and Medicaid Services-64 reports, March 2009.
Suggested citation: Kofke-Egger, Heather; Ehrlich, Emily; Udow-Phillips, Marianne. Health Care Spending by Country, State, and Payer. December 2009. Center for Healthcare Research & Transformation. Ann Arbor, MI.

domain: health


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With the team still not at full health from last season’s Super Bowl, it’s important that every other player in the locker room stays healthy and are able to perform at their highest levels. There was a brief scare when a new name was added on to today’s injury report – DE Michael Bennett.
#ATLvsPHI Tuesday Injury Report
DNP: DE Bennett (knee), WR Hollins (groin), WR Jeffery (shoulder)
Limited: QB Wentz (knee)
Full: RB Ajayi (foot)
— Philadelphia Eagles (@Eagles) September 4, 2018
Bennett’s addition to the injury report was a surprise, but it appears to have been just a maintenance day that needed a body part to be named in the report.
Nothing major to worry about with Michael Bennett, for what I'm hearing. A maintenance deal. Didn't get injured in practice.
— Zach Berman (@ZBerm) September 4, 2018
Bennett should be at full health when he makes his Eagles debut on Thursday night.


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OverDrive gives on-the-go access to eBooks and audiobooks from the library’s website. Download eBooks and audiobooks directly to your computer or to your electronic device.
The TumbleBookLibrary is a collection of animated, talking picture books created from existing picture books that have been licensed from children's book publishers and converted to the TumbleBook format. In addition to books, the site also features puzzles, games and book reviews. Working just like an online music player, TumbleBooks can be preloaded and played one after another. Also available in Spanish and French.


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Majority of council supports Costco plan
Some neighbors say they support warehouse club but not gas station
A majority of Montgomery County Council members support spending $4 million to subsidize the opening of a Costco in the Westfield Wheaton Shopping Center, according to a memo that Council President Nancy Floreen (D-At Large) of Garrett Park sent last week to County Executive Isiah Leggett.
Floreen stated in the memo that five out of the nine county council members approve of the subsidy, which would be paid directly to Costco to help build the $60-million, 232,000-square-foot store. Knowing the council supports the subsidy, Leggett has already forged ahead with the Costco plan by proposing a zoning-text amendment March 16 that would allow gas stations in regional shopping centers, a key component to Costco's proposed development in Wheaton.
Costco, a warehouse club that is based in Washington state, has expressed interest in building at the longtime vacant Hecht's department store at Westfield Wheaton Shopping Center in downtown Wheaton, according to county officials. The plans call for opening a gas station on mall property, in the parking lot next to the store.
The zoning amendment is set to go before the Planning Housing and Economic Development committee in April or May and will likely go to the full council by Memorial Day, according to Steve Silverman, the director of the Department of Economic Development, who spoke on behalf of Leggett on Monday. The subsidy is slated for fiscal 2012 and would go before the Council in sprint of next year, Silverman said.
Current zoning requires gas stations to go through a rigorous special-exception process before being allowed in commercial zones. This process analyzes the proposed station's economic and environmental impact on surrounding neighborhoods.
But Leggett's proposal would eliminate the need for the special-exception process, which residents and their County Council representative say would remove an important safeguard that would ensure that the gas station doesn't harm nearby neighborhoods.
"The gas station would simply be built, and no one from the zoning board would determine if it makes sense," said John Seabreeze, speaking as president of the board of directors of the Kenmont Swim & Tennis Club, which sits directly behind Westfield Wheaton.
The zoning amendment would also set a dangerous precedent for shopping malls in the county, said Donna R. Savage, the interim president of the Kensington Heights Civic Association.
"It says nothing about how many gas stations could be there," she said. "Westfield could raze all their buildings and build a gas station heaven."
One County Councilmember who won't be voting for the zoning amendment is Valerie Ervin, a Democrat from Silver Spring whose district includes downtown Wheaton. In a statement sent to The Gazette on Monday, Ervin said she is "extremely concerned" about the fast-tracked amendment because, like some of her constituents, she fears it could cause increased air pollution and storm-water management troubles. She said she favors reviewing the gas station through the traditional special-exception process.
"The impacts of a gas station located in a regional shopping center are no different than those located outside of a shopping center," she said.
But special exceptions are lengthy, volatile processes that can take years, Silverman said. If the county were to go that route, there's a high chance Costco would back out of the deal, he said.
"This will help it not get hung up potentially for years," he said. The zoning amendment will also allow the Council to consider the gas station and warehouse store as a whole instead of piecemeal, Silverman said.
Silverman also said he doesn't believe Leggett's proposal throws out necessary safeguards.
Westfield Wheaton would likely spend $100,000 in landscaping to buffer the adjacent neighborhoods from the gas station, Silverman said. In addition, the county's Department of Permitting Services will review the zoning-text amendment carefully, he said.
A public meeting on the text amendment is set for 7:30 p.m. April 20.
The subsidy itself is controversial among stakeholders in downtown Wheaton who argue the money could be better spent on supporting local businesses that are struggling.
But Savage said her citizens association does support subsidizing the store without the gas station. She said her community can deal with the traffic the store generates but not fumes the gas station would create.
"We'd be happy with Costco. The community wants the store, we just don't want the gas station," she said.
Staff writer Erin Cunningham contributed to this report.

domain: economics


Having spent some time this weekend in the mountains around Boone, I thought aloud that my mother in Concord NH would probably love to live her golden years down there. As if to read my mind, I received a link to this story from her today:
Retire in Concord, mag says ‘U.S. News’ picks us as one of its top 10
Earlier this month, US News and World Report named Concord one of the 10 Best Places to Retire, citing its pleasant surroundings, chummy environment and "elegant" downtown. Health care, proximity to mountains and bigger cities, the local political scene and New Hampshire’s distinct seasons helped launch the city into the top bracket.
Folks around here were surprised that US News compiled retirement rankings (the magazine is better known for ranking universities) but few disputed Concord’s position on the list. The region’s population has been aging a tad faster than the rest of the country for years and – thanks in part to an influx of 50- and 60-somethings – Concord is expected to grow grayer still.
An older population has its benefits, especially one that includes the often-affluent baby boomers New Hampshire draws. Educated people with resources and free time are likely to volunteer and become involved in civic activities. But as they face the challenges of age, they’re likely to demand services that a community needs a young workforce to provide.
"We’re very blessed here in Concord," Donovan said. "It’s an awfully nice community. I’m not scared by the fact that we’re attracting a graying population, but I do hope it continues to be balanced with young families, too."
Can’t say I’m too surprised.


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Hillary Clinton was trapped by aggressive questioning Thursday by Rep. Jim Jordan (R., Ohio) at the Benghazi Select Committee on her rhetoric initially blaming an anti-Muslim video for the Benghazi terrorist attack, with Jordan showing emails revealing Clinton knew immediately the video wasn't involved and telling her family it was an attack by an "al Qaeda-like group."
The matter went to why Benghazi was such a hot topic during the 2012 election cycle. The Obama administration repeatedly touted having al-Qaeda "on the run" at the time, and Republicans challenged that a terrorist attack of this magnitude would undermine Obamas's re-election campaign narrative.
Jordan showed an email Clinton sent her own family, in which she said officers were killed in Benghazi by a group like al Qaeda.
"You tell the American people one thing. You tell your family an entirely different story," Jordan said.
On the night of the attack, Jordan said, Clinton had a phone call with the president of Libya where she told him Ansar al-Sharia was claiming responsibility.
The next day, Jordan said, Clinton told the Egyptian prime minister something "significant," where she acknowledged they knew the attack in Libya had nothing to do with any video.
"We know the attack in Libya had nothing to do with the film," Jordan read out from Clinton's email. "It was a planned attack. Not a protest. Let me read that one more time. We know, not we think, not it might be, we know the attack in Libya had nothing to do with a film. It was a planned attack. Not a protest. State Department experts knew the truth. You knew the truth, but that's not what the American people got. Again, the American people want to know why. Why didn't you tell the American people exactly what you told the Egyptian prime minister?"
"Well, I think if you look at the statement that I made, I clearly said that it was an attack, and I also said that there were some who tried to justify it on the basis of the video, congressman," Clinton said.
"Real quick, calling it an attack is like saying the sky's blue. Of course it was an attack," Jordan said. "We want to know the truth. The statement you sent out was a statement on Benghazi and you say vicious behavior as a response to inflammatory material on the internet. If that's not pointing as the motive being a video, I don't know what is, and that's certainly how the American people saw it."
"Well, congressman, there was a lot of conflicting information that we were trying to make sense of," she said. "The situation was very fluid. It was fast-moving."
Jordan showed with other emails that her top staffers were already discussing the political ramifications of the attack and how to respond. He said Clinton picked the option of a "video narrative" "with no evidence" because she wanted the Libya situation to be a key success story for the Obama administration.
"You did it because Libya was supposed to be this great success story for the Obama White House and the Clinton State Department, and a key campaign theme that year was GM's alive, bin Laden's dead, al-Qaeda's on the run," Jordan said. "Now you have a terrorist attack, and it's a terrorist attack in Libya and it's just 56 days before an election. You can live with the protest about a video. That won't hurt you, but a terrorist attack will. So you can't be square with the American people."
Clinton replied that Jordan should read her memoir Hard Choices.
"I would be glad to send it to you, congressman, because I think the insinuations that you are making do a grave disservice to the hard work that people in the State Department, the intelligence community, the Defense Department, the White House did during the course of some very confusing and difficult days," she said. "There is no doubt in my mind that we did the best we could with information that we had at the time."
Jordan replied later that he was not "insinuating anything" as Clinton had charged but rather simply reading out what she had said.
"Why didn't you just speak plain to the American people?" Jordan asked.
"I did state clearly and I said it again in more detail the next morning, as did the president," Clinton said. "I'm sorry that it doesn't fit your narrative, congressman."


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A web-based grocery is both a standalone online grocery store or a brick and mortar grocery store which enables on-line ordering, also known as e-retailing. Often there’s a delivery payment attached to this service, but many grocery stores supply free delivery. Online grocery websites are very common on the web. For those who have just about any issues relating to where by and tips on how to employ online shopping in sri lanka, it is possible to e-mail us on our web-page. In actual fact, there are lots of of websites catering to this explicit market.
One of the best on-line grocery supply companies are quick and handy, and they make inserting an order quick and easy. The very best ones provide a cash again guarantee and customer service in case you are not satisfied along with your order. The companies usually cost a surcharge on prime of the particular value of the meals you purchase. This surcharge applies to any taxes and any relevant sales tax. This could appear like an pointless expense, however it is often utilized to cowl costs akin to paying for charges corresponding to having the item ship to your home, having it put on your grocery listing, and so forth.
These charges are usually not handed on to the patron, but somewhat to the corporate who are doing the advertising. Online grocery stores would not have these surcharges, so their costs are usually decrease than most other grocers. Grocery shops sometimes have aisles of canned items, boxed groceries, and other pre-packaged merchandise. Each product has a particular space the place it is positioned and its own particular number of calories. The very best online grocery stores take this information into consideration when calculating their costs.
Grocery retailer customers can shop based on a particular budget. Ordering groceries ahead of time is the easiest way to avoid wasting money on your meals purchases. When you order food in keeping with a specific weight loss plan, you will be capable of eat extra of the healthy foods on the grocery list. Ordering foods ahead of time additionally helps your relations to be more likely to eat healthier meals every meal. As properly, shoppers who order ahead of time tend to have a number of days of groceries in their freezer, allowing them to rotate different wholesome foods between numerous days of the week.
Many on-line grocers have a preferred community of grocery delivery companies. If you have a favorite grocery retailer chain or supercenter, search for a grocery supply service that is obtainable by that chain. A few of these companies even offer free delivery, which implies you will not should pay extra fees for delivery. Grocery supply companies are particularly invaluable if you’re a school pupil who lives away from residence.
Online grocers also often have offers and coupons for frequent users. For those who make an everyday purchase of a certain share of a product, chances are you’ll qualify for a loyalty card program. For those who regularly order a certain quantity of groceries or have a really giant family, you may be eligible for a large discount card. Frequent users are often given precedence seating and early checkout times. This ensures they do not wait too long for his or her food. Some grocery stores offer low cost cards to regular consumers as effectively, but those reductions are often based on volume discounts and are solely good for certain merchandise.
Online Groceries: The rise of e-commerce has additionally led to larger competition amongst on-line grocery stores. That is especially true for grocery supply. Many corporations that offer free supply now ship by way of the Internet. To combat this, many grocery shops have began providing subscription packages. For instance, some offer subscriptions to health and sweetness care, dwelling and backyard, and pet provides.
With increased competition, there are many ways for consumers to save lots of money while searching for groceries online. Savvy consumers will probably be able to find the perfect deals, and save cash, while nonetheless getting what they need to avoid wasting. With the rise of e-commerce, more consumers are discovering the convenience and advantages of grocery gross sales online.

domain: food


Shocking news alert: The North End got a new Italian restaurant. Domenic’s recently opened in the space at 54 Salem St. that was formerly occupied by Vito’s Tavern, and it is reportedly owned and operated by chef Damien DiPaola, the same person who was behind Vito’s Tavern (and who is also behind Carmelina’s, also in the North End).
Vito’s Tavern was a popular spot for pub food like sliders, burgers, and wings (and some Italian-inspired options), and it functioned as the North End’s de facto sports bar. DiPaola’s, on the other hand, is reportedly focused more on Calabrian cuisine, featuring plenty of seafood. Staples in Calabrian cooking include swordfish, cod, sardines, lobster, and shrimp, in addition to vegetables such as tomatoes, eggplant, onions, potatoes, artichokes, and the beloved Calabrian chili peppers.
Eater has made repeated efforts to contact Domenic’s and will update this post as more information becomes available.
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’ @hikemollenkamp @chefdamien617 @carmelinasnorthend @domenicnorthend @bestfoodboston @HiddenBoston @TasteofMassachusetts @boston_bites @top_boston_restaurants @bostonfoodcoma @yummyventures @massholemommy @eatingboston @princessgloriachinfeasts @dailyfoodfill @nocrumbsleftbehind @thebottomlesspit @mitchpls @sweetcarolineeats @thecravingscurator @eastcoastfoodies @nomnom_boston @hungrygirlsofboston @feedthebean @aaron_hungry @olivethenoms @foodcomaboston


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These Wendy's Burger Boxes Are Available For Delivery Until 3 AM
Perfect for your midnight snack!
Have you ever experienced a late-night craving? While it's tempting to whip up instant noodles, you can also just order in because there are food deliveries even past midnight. Wendy's even has a special burger set, Big Bacon Mushroom Melt Whattabox, that's available for delivery until 3 a.m.!
Wendy's Big Bacon Mushroom Melt Whattabox has the Big Bacon Mushroom Melt that has a premium large 100% beef patty, warm cheese sauce, and mushrooms, plus three pieces of nuggets, a regular Frosty, regular fries, and regular drinks. It's really the complete deal, all for the price of P249. Not bad, right?
If you're on a budget, you can also go for the Bacon Mushroom Melt Whattabox that only costs P199. This also includes the Bacon Mushroom Melt burger (regular size version), three pieces of nuggets, a regular Frosty, regular fries, and regular drinks.
Want a different burger? Wendy's also has the Baconator Single Whattabox (P239) and the Dave's Single Whattabox (P249) that both include three pieces of nuggets, a regular Frosty, regular fries, and regular drinks. The Baconator Single uses the beefy patty and tops it with strips of bacon while the Dave's Single uses a beefy patty, lettuce, onion, tomato, pickles, and cheese.
Thinking about what to cook next? Join our Facebook group, Yummy Pinoy Cooking Club, to get more recipe ideas, share your own dishes, and find out what the rest of the community are making and eating!
Got your own version of the classic dishes? Pa-share naman! Get your recipe published on Yummy.ph by submitting your recipe here.


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Congratulations to AP video journalist, Renata Brito, for winning the 2021 Royal Television Society and JST Young Talent of the Year award.
Renata says ‘When I started working at the AP, I barely knew how to film with a camera and my writing wasn’t very good. Without their support, I would not be able to do all of the stories I’ve been able to do.’
The judges agreed that ‘with great commitment she got inside stories when others couldn’t and showed great initiative and compassion’.
Derl McCrudden, AP deputy managing editor for visual and digital journalism said: ‘Renata’s a brilliant eyewitness video journalist. From the intensive care wards in Spain, to remote villages in the Amazon documenting how COVID-19 took hold there, she has put herself in the middle of unfolding news while putting those affected at the heart of the stories she tells.’
He added: ‘This award is so richly deserved as Renata is brave, versatile and creative, but tells her stories with remarkable compassion. We’re thrilled the RTS has recognized Renata’s talent.’
Renata accepted the award virtually at a ceremony live-streamed by the Society.


I am trying to program AD9551. Our instrument board has a AD9551 on it and the board design around AD9551 is as below;
external crystal feeds 25 Mhz signal to external crystal input, RefA has 100 Mhz signal from board, RefB is not connected, and
all A/B/C static control pins are not connected. I am trying to get 16.384 Mhz signal and I used the EVM software to get the control register settings. I attached the screen capture of the EVM software where control register values are displayed.
After programming the control registers with values from the software, I see 12.7 Mhz signal at output1 pin instead of 16.384Mhz and both lock (input/output pll lock signals) pins stays low.


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Monday, June 2, 2014
Murder of a Real Bad Boy by Denise Swanson
Skye is fed up with the contractor working on her house. He never seems to get anything done. She's about to fire him when she discovers his dead body. Now she must deal with finding a new contractor, someone who keeps breaking into her house, discovering the killer, and figuring out her love life -- all at the same time.

domain: literature


Rumors point to the first redesign of the mid-size SUV. But you are unlikely to see a facelift of the 2022 Toyota Highlander. After only three seasons, where the virus has destroyed one of them, it is too early for a new model to emerge. However, some changes will refresh the squad. In addition to the fresh look, the latest generation Highlander introduced a new hybrid setup. In 2022, PHEV could join the mold. Will it be the President of Highlander?
In the next few years, there will be no major changes to the mid-size SUV. Toyota is planning a new generation for 2025. Meanwhile, the priorities are the new Tundra pickup, the 4Runner and the Land Cruiser. Additionally, there are some changes on the way to the Lexus luxury lineup, with the LX being replaced by a full-size LX. So it looks like the 2022 Toyota Highlander is coming unchanged, with all trim levels we can actually get.
2022 Toyota Highlander V6 engine specifications
The main power source for the 2022 Toyota Highlander will be a 3.5-liter V6 engine. It is the most capable engine and a perfect fit for an SUV of its size. Most of the competitors are using similar settings. The Highlander will produce 295 hp and 265 lb-ft of torque. The towing capacity is 5000 pounds. We might hear rumors that an SUV could get a new powertrain that will send power to the rear axle. But this is only speculation at the moment. Front-wheel-drive is still there by default, with the option to upgrade to AWD. The fuel economy is not that bad for the sector. The 2022 Toyota Highlander will be able to return 24 miles per gallon (FWD).
The four-cylinder engine is one of the things we can see as a primary option in the upcoming season. However, such a setup would not be the best option for a mid-size SUV, unless it was equipped with turbochargers. The I-Force Max is new on the road as well, but it won’t show up in the next Highlander, but only in its much larger SUV.
2022 Toyota Highlander Hybrid and PHEV
For a long time, this SUV was the only mid-size model with three rows of seats that had a hybrid engine as the powertrain. But the situation has changed and more automakers are exploring this market. This caused Toyota to make some drastic moves.
The V6 engine was the main power source, and the hybrid version could produce 310 hp. The Japanese automaker has sacrificed power by replacing the V6 with a four-cylinder unit. This reduced the power to 243 hp, but the SUV gained a major boost in the fuel economy sector. Now 2022 Toyota Highlander Hybrid will return 36/35 mpg. There aren’t many compact crossovers that can provide such fuel efficiency. The Highlander is bigger and stronger. The 2.5 liter capacity is the main source of power and the hybrid model will also offer front-wheel drive and four-wheel drive.
Also read : 2022 New Toyota Hilux Full Review New
The next step is the plug-in release. Several experts suggest that the 2022 Toyota Highlander will be the next model to get such a configuration after the Rav4. The compact crossover can generate 300 hp and the electric range is 42 miles. Of course, the Highlander Prime will be bigger and heavier. On the other hand, larger batteries can provide additional power and range. If Toyota sticks to this step, we’ll learn more early next season.
2022 Toyota Highlander models
The base version of the 2022 Toyota Highlander will still be the L version. This model is now updated with Safety Sense 2.5. It really is a difference compared to previous releases. Additionally, Toyota has finally added Apple CarPlay and Android Auto to its Entune entertainment system. A three-zone temperature control system and an 8-inch touch screen are also standard. Enhance your driving with the electric tailgate and blind spot screens. The LE package will offer these features for both the Standard and Hybrid versions. Additionally, a leather steering wheel and fog lights have been added.
XLE expands the leather to all upholstery. The driver’s bucket has 10-way adjustable positions, while the overall design transforms into a six-seat bench with captain’s chairs in the middle row. An electric sunroof and heated front seats are among the exclusive options that the XLE SUV will have. 2022 Toyota Highlander XSE is not available with a hybrid engine. It also makes the drive sportier and with improved suspension and steering, the appearance is more aggressive. There are 20-inch wheels and exhaust tips.
The upper editions of the collection are limited and platinum. The former uses premium interior leather, premium JBL sound, and a hands-free tailgate. Not many features remain for the Highlander Platinum. But the 12-inch infotainment screen and HUD will get the job done. Additionally, buyers will find a panoramic sunroof and a fully digital rearview mirror.
The price of 2022 Toyota Highlander will remain the same. The base MSRP starts at $ 36,000 with the destination rate. The Egyptian pound will add more than $ 2000 and four-wheel drive costs $ 1500-2000. The cost of the densely loaded Platinum package with a hybrid unit is over $ 50K.
2022 Toyota Highlander Hybrid
You can never be sure of a Japanese automaker. They recently overhauled the engine range and we can already hear rumors about the next steps for the 2022 Toyota Highlander Hybrid. According to speculation, engineers are working to develop an advanced system based on PHEV configuration. Well, we’ve seen that coming, but not soon. We’re still trying to get used to the mid-size SUV that goes back 35 mpg. You will hardly find a compact crossover with such an output. Toyota issued a statement regarding the mileage of gas, and before competitors had a chance to respond, the engineers of the Japanese company were already on the new assignment.
For a time, the Highlander was the only three-row midsize SUV with a hybrid transmission. As other automakers started to catch up, Toyota took the game to a whole new level. 2022 Toyota Highlander Hybrid will give you the best fuel economy in its entire class. Well, this isn’t the first time that the Japanese company has attracted buyers with this. The Rav4 crossover was the world’s first small SUV model to reach 40 mpg. You also get a PHEV setting, called Rav4 Prime. 2022 Highlander Prime is also an option for the name.
Also read : 2022 Toyota Corolla, Cross Full Review New
022 Toyota Highlander Hybrid specifications, gas mileage
Toyota took a big step when it decided to reduce the power of its midsize SUV and sacrifice it for a better mpg rating. The V6 engine is still there as a primary option. The gasoline engine is good 290 hp. When it was the hub of the hybrid, the SUV offered 308 bhp and nearly 30 mpg combined fuel economy.
So the engineers decided to replace the V6 engine with a four-cylinder mill. Connected to an electric battery, the 2022 Toyota Highlander Hybrid can produce 60 hp less than its predecessor. Still 245 ponies good for a smooth ride. But the main goal was fuel economy. Now the SUV returns 35 mpg and it is this detail that will appeal to buyers looking for excellent miles Well, the Highlander now produces more power than many smaller crossovers and provides better mileage and payload at the same time.
022 Toyota Highlander Hybrid Electric hybrid
The next step in evolution is definitely the 022 Toyota Highlander Hybrid plug-in, and we’ve seen the same moves on the Rav 4. Well, although it’s a compact crossover, the principle is the same. After the great hybrid system, comes the alternative PHEV. In the future, the Highlander will become an all-electric SUV. This is the trend of the entire auto industry. The PHEV won’t beat the fuel economy of the standard hybrid. But this version will improve the power output. For example, Rav4 Prime will produce 302 hp. Moreover, Toyota Highlander PHEV 2022 will be able to go some distance using only an electric motor. Since it is bigger, there will be more space for a battery of larger capacity.
022 Toyota Highlander Hybrid Minor cosmetic changes, TRD model, and more updates
The latest generation of the mid-size SUV made its debut in 2019 with a completely new look. The first facelift is not expected until 2023. The automaker is focusing on updating other models, with the full-size category being the priority. Toyota is preparing a new engine that will be available for all flagship models. You can read more about it in our Land Cruiser 2022 review.
So the Highlander is still new and all we’re hoping for are slight body changes. Inside, the infotainment system will be updated. Toyota introduced Apple CarPlay and Android Auto services, which are now available with Entune. More security options and additional features are also expected for the advanced packages.
Toyota recently added another model to its TRD Pro lineup. Well, fans were hoping to see Highlander there, but a full-size Sequoia has taken its place. However, in the future, there will be more models with the Off-Road Package. On the other hand, the 2022 Toyota Highlander Hybrid is more focused on fuel economy strategy and environmentally friendly reports paper, rather than strength and skills. Another mid-size SUV from the same automaker that is an off-road adventure favorite – the 4Runner, especially if it equips the TRD Pro package and off-road tires.
Also read : 2022 Toyota 4Runner Full Review New
2022 Toyota Highlander Hybrid release date
The arrival of the new vehicle is dependent on the development of a system of additional components. There are rumors and speculation, but the presidents are still silent about it. The 2022 Toyota Highlander Hybrid, the standard configuration, will remain unchanged and will be available by the end of 2021. On the other hand, the PHEV could be around a little later, perhaps as a kind of upgrade for 2022. The Highlander Prime will be priced over $ 45,000. The base SUV costs $ 34,000 and the Hybrid adds about $ 3,500. The PHEV system for the smaller RAV4 is roughly $ 10,000 over the standard hybrid and $ 12,000 more expensive than the base configuration.
2022 Toyota Highlander Platinum
This specific age group may be redesigned for 2022 Toyota Highlander Platinum. Regarding the latest media, you can make your roads productive after that calendar year. The new Highlander is a popular domestic SUV and still one of about 3 series. Its content contains a huge, huge and lively cabin of seven tourists. Under the hood, the new Highlander continues to offer a few gearbox capabilities, along with a specific hybrid system. This appears to be more recent spy shots and may well be Highlander’s fitting proximity to some of the cues in the lightweight RAV4 crossover.
2022 Toyota Highlander Platinum redesign
Currently, there are no photos that can be used inside. However, starting with the template, this version can be well reconstructed by the surface. The organization runs several quality products and many standard features can be incorporated. As before, Highlander’s approach can be presented for various reasons.
2022 Toyota Highlander Platinum has three sets of car seats; In addition to the LE, it will also provide 8 passengers with handlebars like the L. In addition, this particular SUV has a special pressure. It contains 16.1 cube fingers with load chamber to reset the row, improving to 40.6 with shrinking 60/40 split table plus 73.3 cube fingers while using two easily foldable backstitches.
2022 Toyota Highlander Platinum interior design
Since we released the 2022 Toyota Highlander Platinum check-up it will likely be identified, and it’s really hidden. However, some external changes are evident. You will notice a little redesign of each look. However, some minor changes can make this product technically attractive. The subtle front end of this SUV uses an all-new grille and overhead turn signals with dampers at the top of the front fascia provided. Toyota Highlander Platinum comes in TNGA design.
Back-evaluation is dangerously hidden, and there’s often no clear-cut place to figure out what to convert. In terms of defaults, the Highlander could get a more robust design with multiple taillights. In terms of proportions, the revolutionary special design could be slightly larger than the previous design, using a larger total number of beads from 2.36 “to a total of 194.9”.
2022 Toyota Highlander Platinum engine
Your 2022 Toyota Highlander, which may approach 2022, is still close to exactly the same 2.7-liter engine. This multi-tube engine delivers 185 horsepower plus 184 pounds of torque as per the current design. In addition, it has a variant of the six-speed automatic transmission.
Usually the rookie engine is stronger. Highlander will definitely use the 3.5-liter V6 engine with 295 hp and 263 lb. This particular engine features an intelligent, powerful seven-speed transmission. The front tire movement pattern is typical of models, although AWD will not be required. The grab capacity is 5,000 kg if the vehicle was already manufactured under a non-mandatory towing agreement available.
2022 Toyota Highlander Platinum release date and price
The upcoming 2022 Toyota Highlander Platinum will likely be slightly restyled. Another version that hardly offers you themes. However, the price may be exactly the same, and the specific discount design starts at around $ 33,500. The hybrid would definitely improve the price to help $ 40,000. Platinum minimum, most ready-made, starts at $ 47,000. AWD setup is not required on all versions and costs $ 1,800.


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The Fleshtones have always called it super rock. That’s their name for the peculiar blend of garage rock, surf, honking party music and monster kitsch they play. The Fleshtones often sound like a more menacing version of the B-52s mixed with the Kingsmen.
Formed in New York City during the mid-'70s, when a punk energy and disdain for epic rock bloat led to fuzz and attitude, the Fleshtones played with a manic, boozy drive. They obviously had a fondness for early rock 'n' roll, soul and psychedelia, sloshing everything together into an exuberant farfisa-drenched confrontational noise.
They weren’t without a message, either. On “New Scene,” they stated it plainly: “Phony society, we reject your false values.” The band, formed in 1976, has been making music for over 40 years. They’re party-animal survivors, thumbing their noses at rock bombast and hoisting retro cocktails to bacchic hell-raising.
The Fleshtones play Cafe Nine, 250 State St., New Haven, on Jan. 25 at 9:30 p.m. Tickets are $15. 203-789-8281 or cafenine.com


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Colour Be Back (enhance pigments)
Colour Be Back is designed with natural ingredients to provide the necessary minerals for your animal to enhance pigments to eyes, hair, skin, gums, lips and mouth. Some people have said to me we have tried kelp and it hasn't worked that is because we use a specific species of kelp for this product.
Ingredients - Chlorophyll, Spirulina, Eggs, Liver, Kelp.
Daily Feeding Instructions
Cats/ Puppies - 1 teaspoon per day
Medium Dogs - 2 teaspoons per day
Large dogs - 1 tablespoon per day


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Carmen Paquette, born in 1946, is a Franco-Ontarian feminist, who, for almost three decades, has purposefully bridged different social movements in Canada and internationally. Carmen's history of accomplishments in the Ottawa LGBT community includes significant roles with Gays of Ottawa, the Coalition for Lesbian and Gay Rights in Ontario, and Ottawa's Pink Triangle Services. She was a lobbyist with, and President of, Equality for Gays and Lesbians Everywhere (EGALE) and the founder of Ottawa's first International Lesbian Week.
A former Human Rights Commissioner, Carmen received the Lifetime Achievement Award at Capital Xtra's 'Heroes of 2000: Lesbian and Gay Community Achievement Awards" ceremony. She has been a valued volunteer with Ottawa Senior Pride Network for a number of years.
She states: "I have always strongly believed that all oppressions are linked and that therefore those fighting for social justice need to be aware of and support other struggles".
(taken in part from the bio from Carmen Paquette’s induction in the CLGA’s National Portrait Collection)


General Motors said on Tuesday that it is acquiring an 11% stake in US electric truck maker Nikola Corp, worth about $ 2 billion, and will team up with the company to make a pick-up truck.
Nikola's Shares rose more than 30% to $ 46.30 in pre-market trading after GM's investment, helping the company take on the likes of Tesla and Ford.
The companies will jointly build the Nikola Badger truck and expect production by the end of 2022. The truck will compete with Tesla Inc's Cybertruck, as well as the electric pickup trucks planned by Rivian, Ford Motor Co and GM itself.
Nicola claims the Badger will have a range of 600 miles, compared to the Cycbertruck's range of more than 500 miles. The Cybertruck and other electric pickups have not launched yet.
The alliance with Nikola is the second-largest deal in a week for General Motors and highlights the pressure the auto industry faces to share costs to meet demands for cleaner vehicles. Last week, it announced a partnership with Honda Motor Co. of Japan to develop new inte
al combustion models.
Also Read: Best cars under 10 lakhs in India
The agreements also indicate the urgency of CEO Mary Barra's efforts to convince investors that GM can cut costs in its traditional inte
al combustion business and develop a profitable and viable electric vehicle business to compete with Tesla.
Shares of GM, which had been stuck for months at levels below $ 33 a share, the 2010 post-bankruptcy public offering price, rose about 6% in premarket trading.
General Motors will receive $ 2 billion in newly launched Nikola stock and will have the right to nominate a director to the Board of Electric Truck Manufacturers.
He expects to receive benefits of more than $ 4 billion in capital and contract manufacturing for Badger, among other benefits as part of the deal.
The companies expect to save $ 4 billion in battery and powertrain costs over 10 years and more than $ 1 billion in engineering and validation costs.
Also Read: All-Electric Ride-Hailing Platform – Blusmart raises ₹ 51 Crores In Funding
General Motors acquires 11% stake in electric truck maker Nikola
Sep 9, 2020


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There was a correlation between postoperative glucose levels and an increased risk of periprosthetic joint infection after total joint arthroplasty, according to published results.
Tranexamic acid has been shown to be cost effective and beneficial in reducing the risk of transfusion after total joint arthroplasty, according to a presenter.
Pain is the main impetus for seeking medical care among patients with osteoarthritis, with insomnia and depression acting as drivers for increased diversity in the types of health care use, according to recent findings in Arthritis Care & Research.
Many patients who received non-opioids were surprised by how well they relieved pain, according to data published in the Journal of Pain.
In patients who underwent total hip arthroplasty for osteoarthritis, use of a crosslinked polyethylene bearing surface was linked to a significantly reduced revision rate at 16 years compared with conventional polyethylene, according to recently published results in The Journal of Bone and Joint Surgery.


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Creative Digital City’s (CCD) development plan is designed to work as a catalyst for innovative ideas in one of the sectors with the most productive and economic growth worldwide: the creative industry.
The plan is aimed at two great strategic lines. The first one consists in the strengthening of the creative digital industry, capable of generating intellectual property expressions linked to technological innovation; the second one, in establishing a competitiveness and entrepreneurship framework.
The digital hub is a concrete action that serves this purpose through an urban and connectivity infrastructure that allows to secure business networks and strong profitable collaboration links in all the creative ecosystem’s value chains.
“Strengthen the digital creative industry and establish a framework for competitiveness and entrepreneurship”.
The journey begins reassessing ideas to amplify them and boost their formation through an incubation process. Subsequently, and with the participation of the companies that will have access to resources, new products will be developed with the intention of positioning them internationally.
Within this entrepreneurship framework, CCD has the following initiatives:
CCD VENTURES: it is a 96 million pesos venture capital fund, which will be distributed between April and May 2015 to the most outstanding projects from a list of 300 registered participants.
CCD Incubator: still in process of developing, this instrument will lead with an entrepreneurial approach the formation of creative digital projects, many of which will launch from those registered to CCD Ventures.
INGENIUM EDUCATION MODEL: CCD works for the transformation of the current educational model together with the academic and creative sectors.
The goal is to breed talent, from elementary level to specialty, that respond to constant technologic, social, economic and pedagogic changes.
GLOBAL PROMOTION: : it is a group of linking actions to international institutions that will promote the opening of new markets and the strengthening of local industries with a global vision.
PROGRAMAS DE INCENTIVOS:: to boost ideas and promising companies.
“The journey begins with appreciation of the ideas to empower and accelerate the process of incubation”.
With these and other initiaves, CCD will contribute to the productive boosting of the city, as well as to the formation of talent and the strengthening of economy in the creative and digital areas.


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domain: hobby


A micrometre-sized device that produces light by firing a beam of electrons over a slab of crystal could be used to build tiny particle accelerators and X-ray machines. Such chip-sized devices could be manufactured more quickly, cheaply and compactly than current particle accelerators.
Built by Yi Yang at the University of Hong Kong and his colleagues at the Massachusetts Institute of Technology, the new device consists of a special piece of silicon called a photonic crystal, a modified scanning electron microscope that fires a beam of electrons over it and a device that detects the emitted light. The set-up takes advantage of the electromagnetic fields that surround electrons as they move, which can make charged particles within a nearby material – in this case, the photonic crystal – become excited and emit light.
From mathematical models, the researchers knew that they could enhance the interactions between the crystal and the electrons by adding a pattern to the former, so they etched a grid of circular indentations, each about 100 nanometres wide, into it. Light and electrons don’t normally interact much, but engineering the energy and momentum of the light to match that of the electrons allows for unusually large interactions between the two. This matching method could eventually enhance light emissions up to a million times, says Yang.
That light has many potential uses, from spectroscopy, in which the light helps scientists learn about the internal structure of different materials, to light-based communication.
Notably, it can be used to make tiny particle accelerators, says Peter Hommelhoff at the University of Erlangen-Nuremberg in Germany. Researchers could use intense light pulses to accelerate particles instead of hitting them with microwaves, as is more common, he says.
Thomas Krauss at the University of York in the UK says the new device may not only be a step toward tiny particle accelerators but also toward smaller X-ray machines. X-rays are essentially light waves with wavelengths too short for us to see. By adapting the silicon pattern and the speed of the electrons in the device, it might be possible to change the wavelength of emitted light to X-rays.
“When you get an X-ray at your doctor, it’s a big beast of a machine. Now we can imagine doing it with a little light source, on a chip,” he says. That could make X-ray technology more accessible for small or remote medical facilities or make it portable for use by first responders in an accident.


Immigration and Customs Enforcement arrested 81 people in Colorado and Wyoming as part of a seven-day sweep that targeted immigration fugitives and illegal immigrants with criminal records, ICE announced today.
More than 2,400 people were arrested nationwide as part of the May operation, which authorities say was the largest of its kind.
Of the 81 in the Colorado/Wyoming enforcement area, 79 were in Colorado. The bulk of those arrests occurred in Denver, Aurora and Commerce City.
Included among the arrestees was a 51-year-old man from Libya living in Denver who had been convicted of first-degree sexual asault against a child and domestic violence, according to ICE.
The agency has not released the identity of the other arrestees.
The enforcement was part of ICE’s ongoing efforts to prioritize the removal of illegal immigrants who threaten public and national security, said ICE Director John Morton.