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“The Castle of Otranto” by Horace Walpole: The Earliest Gothic Novel Cloaked In An Eerie And Supernatural Atmosphere
Introduction: The Birth of Gothic Fiction
“The Castle of Otranto” by Horace Walpole holds an esteemed position in the annals of literary history, heralded as the inception of the Gothic novel. Its publication in 1764 marked a revolutionary shift, unveiling a narrative that captivated readers with its haunting allure and enigmatic depth. This extraordinary literary masterpiece emerged as a pivotal moment, setting the stage for a new wave of storytelling that delved into the obscure and the macabre, birthing an entire movement within the realms of literature. Walpole’s work etched a compelling saga, a tale that both intrigued and unsettled audiences, laying the sturdy groundwork upon which the Gothic literary tradition would flourish.
The Gothic Emergence in Literature
Prior to the emergence of “The Castle of Otranto,” the realms of mainstream literature scarcely delved into the realms of horror and the supernatural. Horace Walpole’s audacious departure from traditional storytelling unleashed an unprecedented fascination for the enigmatic and the eerie, instigating a profound shift in literary preferences. This bold divergence from the norm sparked an insatiable curiosity for the macabre, birthing an entirely new literary movement that would reshape the literary landscape indefinitely. Walpole’s pioneering work catalyzed the Gothic literary movement into the forefront of readers’ imaginations and forever altered the trajectory of literary exploration and expression.
The First Gothic Novel: An Exploration Of “The Castle of Otranto” By Horace Walpole
Amidst the ominous confines of Otranto’s imposing walls, a saga steeped in chilling encounters and perplexing occurrences unfolds. The protagonist, Manfred, driven by an insatiable desire to secure his lineage following the tragic demise of his son Conrad, finds himself ensnared in a labyrinth of inexplicable events. Within the castle’s eerie corridors, whispers of ghostly apparitions permeate the air. At the same time, foreboding omens and cryptic prophecies cast an unsettling shadow over the narrative, plunging it into an abyss of palpable suspense and unrelenting dread. The interplay of supernatural occurrences and Manfred’s fervent pursuit weaves a tapestry of unease and anticipation, enveloping readers in a gripping tale that unfurls with each haunting revelation within the echoing halls of Otranto.
Eerie Atmosphere and Supernatural Encounters
Walpole’s genius lies in his ability to immerse readers within an atmosphere saturated with the inexplicable and the otherworldly. Through his masterful storytelling, he crafts an elaborate weave of the supernatural that haunts readers, infusing every scene with an eerie and unsettling ambiance. Otranto transcends its physicality, transforming into a character, its brooding presence looming large and casting an ominous shadow over the unfolding drama. The castle’s ancient walls, whispering corridors, and enigmatic chambers evoke a sense of foreboding, enveloping the narrative in terror and anticipation. Manfred’s relentless quest for power, entangled within the web of mysterious events, serves as a catalyst, intensifying the already charged atmosphere. Manfred’s insatiable ambition, combined with the inexplicable occurrences within Otranto, creates an amalgamation of suspense and fear that permeates every page. Each twist in the tale, each revelation, heightens the palpable tension, compelling readers to delve deeper into the enigmatic depths of the narrative, shrouded in an atmosphere filled with unease and apprehension.
The Symbolism In “The Castle of Otranto” By Horace Walpole
“The Castle of Otranto” by Horace Walpole intricately threads a rich array of symbolism, enriching the narrative’s depth and complexity and inviting readers into a realm where every element carries significant metaphorical weight.
- The Castle Itself: Walpole utilizes the castle as more than a mere setting; it embodies a dual nature of power and confinement. The towering walls and oppressive corridors mirror the characters’ entrapment within their desires and societal constraints. It is a formidable structure, symbolizing dominance and the suffocating limitations imposed by tradition and authority.
- The Supernatural Elements: The supernatural occurrences within the castle serve as harbingers of fate and turmoil, shrouding the atmosphere in an eerie and mysterious veil. Ghostly manifestations, ominous omens, and prophetic warnings underscore the characters’ anxieties, secrets, and the unforeseen consequences of their actions, foreshadowing their tumultuous fates.
- The Armor and Helmet: The colossal helmet and enchanted armor bear the weight of the past, signifying the burden of ancestral lineage and the attempts to shield oneself from the repercussions of their forefathers’ deeds. They remind us of legacy and concealment, highlighting the characters’ struggles with their heritage and the inevitable consequences of past choices.
- The Portrait of Alfonso the Good: Contrasting the tyrannical reign of Manfred, the portrait of Alfonso represents benevolence and nobility. It is a beacon of goodness, underscoring the dichotomy between virtue and corruption, emphasizing selfish ambition’s moral conflicts and consequences.
- The Giant Sword and the Bible: These opposing objects embody the clash between conflicting ideologies. The sword symbolizes aggression, power, and dominance, contrasting with the Bible’s representation of morality, righteousness, and spiritual guidance. Their presence underscores the characters’ moral dilemmas, the struggle between good and evil, and the choices that shape their destinies.
- The Plumes: The plumes adorning the giant helmet in the castle symbolize ostentation, pride, and authoritative display. They amplify the helmet’s grandeur, underlining the castle’s imposing dominance and the characters’ subservience to its influence. These plumes deepen the sense of entrapment within its colossal walls, highlighting authority and the castle’s intimidating presence. They reinforce the castle’s formidable stature, strengthening the themes of power, captivity, and the characters’ resistance against overwhelming forces.
Each symbolic element in “The Castle of Otranto” transcends the confines of its literal representation; creating an intricate mosaic of symbols, Horace Walpole showcases his masterful storytelling ability, adding deeper meanings, moral quandaries, and thematic complexities that resonate with readers long after the final page. Walpole’s masterful use of symbolism enriches the story, inviting contemplation of the human condition, societal constraints, and the enduring conflict between morality and corruption.
Characters Of “The Castle of Otranto” By Horace Walpole
In “The Castle of Otranto,” Horace Walpole exhibits exceptional skill in intricately portraying a diverse cast of characters, each bearing their complexities and contributing distinct hues to the narrative’s vivid palette:
- Manfred: A towering figure of authority, Manfred embodies a paradox of strength and vulnerability. His insatiable hunger for power leads him to moral decay and internal conflict. The layers of ambition, guilt, and desperation within Manfred unravel a multi-faceted character, haunted by the shadows of his actions and the weight of his ambitions.
- Isabella: A beacon of resilience and innocence, Isabella symbolizes hope amid the castle’s dark corridors. Her defiance against Manfred’s tyranny and unwavering determination to break free add a touch of courage and optimism to the narrative, representing the strength of the human spirit against overwhelming odds.
- Matilda: Matilda’s character is a tapestry woven with loyalty, conflict, and familial ties. Her allegiance to Isabella and Manfred creates a web of moral complexity, portraying the intricacies of human relationships. Matilda’s inner turmoil and struggle with conflicting loyalties enrich the narrative, unveiling the complexities of choices and their repercussions.
- Theodore: Theodore embodies honor and integrity, serving as a contrast to the darkness shrouding the castle. His quest for truth and unwavering commitment to justice make him a guiding light amidst the eerie happenings, a champion of righteousness in a realm clouded by deceit and malevolence.
- Frederic: Though absent physically, Frederic’s presence echoes throughout the storyline, influencing the emotions and decisions of other characters. His absence sets in motion a series of tragic events, emphasizing the role of fate and destiny in shaping the lives of those entangled in Otranto’s enigmatic grasp.
- Jerome: Jerome, the monk, stands as a voice of reason and guidance amid supernatural turmoil. His resolute commitment to revealing the truth and allegiance to Theodore provides a moral compass amidst the chaos, embodying wisdom and clarity in the face of inexplicable occurrences.
- Hippolita: Hippolita represents a portrayal of submission and quiet strength. Her character epitomizes the societal expectations placed on women during that era, showcasing resilience and endurance while silently bearing the burdens imposed by Manfred’s actions.
- Diego: A figure of wisdom and experience, Diego’s counsel offers insights into the events within the castle, presenting a historical context that enriches the narrative’s depth.
Each character in Walpole’s tale brings a distinct perspective and depth, contributing unique shades to the story’s canvas. Their interwoven lives, conflicts, and moral quandaries intricately shape the fabric of the narrative, painting a mesmerizing portrait of human virtues, flaws, and the enigmatic forces governing their fate within the haunting walls of Otranto.
The Moral Lessons In “The Castle of Otranto” By Horace Walpole
“The Castle of Otranto” is a literary work ripe with timeless moral lessons intricately woven into its fabric:
- Consequences of Ambition: The novel is a cautionary tale, vividly portraying the repercussions of unchecked ambition. Manfred’s unbridled quest for power leads to a series of tragic events, underscoring the dangers of overwhelming ambition and its toll on individuals and their surroundings.
- Value of Integrity and Honor: Characters like Theodore embody integrity and honor. Their unwavering commitment to truth, justice, and moral rectitude starkly contrasts the deceit and manipulation within the castle’s walls. Their actions serve as a moral compass, highlighting the significance of principled conduct even amidst adversity.
- The Futility of Suppressing Truth: The narrative eloquently conveys the futility of concealing the truth. Consequently, efforts to veil secrets within the castle have led to chaos and calamity, highlighting the significance of openness and sincerity in averting disastrous outcomes.
- Resilience in Adversity: Characters like Isabella symbolize resilience and fortitude amid oppression. Their steadfast determination to confront adversity with dignity and courage is an inspiring testament to resilience, imparting a valuable lesson on enduring strength.
- Impact of Fate and Destiny: The novel contemplates the influence of fate and destiny. The interconnected lives of the characters and the interplay of events underscore the role of fate in shaping their trajectories, offering an exploration of the complexities of destiny and its profound effects on individuals’ lives.
- Reflection on Gender Roles: Through characters like Hippolita and Isabella, the novel subtly challenges traditional gender roles prevalent in the era it portrays. It prompts reflection on women’s constraints and challenges within a patriarchal society, contributing to a deeper understanding of societal norms and their impact on individuals.
“The Castle of Otranto” transcends its status as a mere Gothic tale, serving as a repository of profound moral lessons. It prompts readers to ponder ambition, integrity, resilience, truth, destiny, and societal constructs, inviting introspection and fostering a deeper appreciation for the enduring relevance of its moral themes.
The Legacy and Influence Of “The Castle of Otranto” By Horace Walpole On Gothic Fiction
“The Castle of Otranto” is a novel and a considerable work that ignited an enduring fascination with the Gothic genre. Its profound impact reverberated across literary epochs, enduringly impacting future generations of writers who ventured into realms exploring Gothic, horror, romance, and the enigmatic. With its haunting allure and eerie mystique, Walpole’s narrative served as a catalyst, inspiring a wave of storytellers to delve into the shadowy recesses of human imagination. The novel’s legacy extends far beyond its time, evident in the labyrinthine tales of haunted mansions, ethereal specters, and enigmatic enclaves concealed within ancient structures that have permeated literature. Its influence is woven into the fabric of countless narratives that echo its themes, lingering in the haunted corridors of gothic tales where the supernatural collides with human emotion, where terror and romance intertwine amidst the forgotten ruins of centuries-old estates. Walpole’s creation paved the way for many narratives brimming with mysterious secrets and haunted by the specter of the unknown. Its enduring heritage continues to enchant readers and writers alike, beckoning them to explore the enigmatic, to unravel the eerie, and to embrace the uncanny within the shadowy realms of the Gothic, forever preserving its vision as a pioneering force that reshaped the landscape of literature.
Conclusion: The Enduring Legacy of Gothic Fiction
Horace Walpole’s “The Castle of Otranto” remains a cornerstone of literary innovation, a timeless masterpiece that unveiled the captivating allure of Gothic fiction. Within its pages resides an atmospheric texture woven with haunting elements, supernatural motifs, and a narrative that leaves an indelible imprint on readers’ imaginations. Walpole’s visionary work laid the foundational stones for a genre that transcends time, weaving the threads of suspense, terror, and enigma into a literary artwork that continues to enthrall readers across generations. The enduring impact of “The Castle of Otranto” resides in its capacity to carry bibliophiles to a world where the line between the mundane and the mystical blurs. Its atmospheric intensity beckons readers into a world of eerie mysteries, spectral encounters, and emotional depths that resonate with primal fears and desires. Walpole’s narrative mastership in crafting an environment suffused with suspense and terror has, over centuries, enchanted audiences, inviting them to explore the enigmatic corridors of Gothic literature. The legacy of this literary milestone remains powerful, its influence spanning centuries and fostering a genre that thrives on the allure of the unknown. Its ghostly whispers and haunting echoes resound through the halls of literature, beckoning readers to immerse themselves in the chilling embrace of the Gothic, evidence of the enduring power of suspense, terror, and the enigmatic within the realm of storytelling.


GALLIA COUNTY, Ohio (WSAZ) -- Another robbery has happened at a convenience store in Gallia County -- this time at the Speedway on Jackson Pike in the Spring Valley area.
It happened just before 1 a.m. Tuesday, the Gallia County Sheriff's Office says.
The man responsible was not armed. This was the second time the store was robbed in the past couple of weeks.
Deputies are trying to determine if the robberies are connected and if they're connected to two other robberies that happened last week.


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TARGETING THE "UNDRUGGABLES"
Only a quarter of the proteins implicated in human diseases are currently druggable by traditional approaches for developing small-molecules compounds. Thus, new approaches directly targeting messenger RNAs of disease genes open up unprecedented opportunities for drug development. At Rgenta, we develop novel methods to mine the wealth of genomics data to identify high-efficacy and high-specificity RNA target sites. We also build focused compound libraries likely to recognize the RNA target sites and modulate their function, particularly those mediated by the regulatory proteins. Our unique approach has resulted in new lead compounds for previously undruggable targets in a range of human diseases.
Rgenta's Novel Approach
Selective modulation of RNA splicing and processing
Rgenta’s integrative RNA-targeting discovery platform
Thousands of unique mRNA/RBP/spliceosome interactions in target genes identified for drug intervention.
Robust HTS assays specifically designed for RNA/RBP interactions.
Custom designed RNA targeting selectivity panel to drive selectivity.
RNA-targeting small molecule design principles and multi-parameter optimization.
Target Discovery Engine
Data-driven target discovery platform integrates RNA regulation across tissues and cell types to exploit the biological modulation for therapeutic benefit.
Lead Discovery Engine
Robust assays tailored specifically for the mechanism of action of interest and custom-designed compound libraries enable rapid screening and lead generation.
Lead Optimization Engine
Lead optimization platform applies medicinal chemistry expert knowledge and multi-parameter optimization design principles to improve lead compound pharmacological properties.

domain: medical


There are 45 results.
"gugler! build & print triple zero" - subproject 9: Monitoring Gugler - Monitoring, evaluation, optimization GUGLER
The project objective is the measurement of relevant building values (energy consumption, ...), the evaluation of these values compared with the intended objectives and the optimization of the system based on the measured data. As a special innovation, monitoring the storage of alternatively generated electricity using photovoltaic and wind energy in the form of compressed air must be considered.
Development of a cost-efficient all-in façade greening system („Greening-Toolkit“) including a maintenance concept, involving all trades and processes, for a broad (facing roads) implementation on facades in the urban built environment, combined with a process innovation for simplification of all necessary coordination processes.
The subproject 10 is part of the flagship project BIGMODERN. It is based on the results of subproject SP 7 in which a monitoring concept has been developed. This concept is now implemented through monitoring of different aspects occurring during the first two years of operation of both BIGMODERN demonstration buildings.
Development of a pattern for comprehensive documentation of the project results. The concepts contain amongst others monitoring of energy consumption, resources, costs, functionality and comfort, etc.
DeLight Monitoring - Demo light Impact-Monitoring and metrological investigation of energy-efficient buildings
The Project consists of the metrological examination of eleven innovative buildings in terms of energy consumption and user comfort. In addition, building constructors and operators as well as the public are sensitized to the subject of energy-related optimization of building operation. Also, the potentials of energy-related optimization of building operation are shown.
Demonstration building of the eco²building system: First passive house prefabricated wood building system for commercial and industrial buildings
The EU funded "eco2building" construction system in a timber-frame based modular design represents a systematic approach for energy efficient commercial and industrial buildings. The object of the eco²building demonstration project - the logistics centre in passive-house quality for "Eine Welt Handel AG" - in Niklasdorf was to optimize the planning and construction processes and prepare for the market launch of the eco²building construction system. Accompanying research monitored and disseminated the experience.
Development of affordable building equipment and services for future "Energy Plus houses" (Plus-Hybrid)
"Plus-Hybrid" integrates knowledge and experience from current activities and complement them by adopting a holistic approach, considering the intelligent interconnection of components as well as managing the planned efforts and human resources in time. The goal of this project was to develop affordable building equipment and services for future "Energy Plus houses".
Digital Twin / Building Tracker - Coupling of building simulation with a physical building in real time
The goal of the project ist o couple an office building during operation with its virtual twin, the "building tracker", which will be developed and applied for the first time within the project. Thanks to coupling of monitoring and simulation, innovative building energy management of nearly zero-energy building is possible.
The multifunctional neighbourhood "+ERS - Plus Energy Network Reininghaus Süd" was realized within the urban planning area of Graz-Reininghaus. The project aims to optimize the energy concept of the single buildings as well as of the building cluster in order to achieve a plus-energy standard within the residential neighbourhood.
EDEN - Developement of a structured data and preparation documentation with a minimized error-proneness for energy performance cerificates.
Current energy performance certificates hold major flaws. Therefore, the presented research initiative aimed at the development of a standardized and easy-to-use, generic Input-Data-Documentation, which ensures the quality of energy certificates for all involved stakeholders. During the development, the documentation had been conducted and for a chosen sample of representative buildings, which is expected to demonstrate the high potential of such a development.
The major objective of the project EnRiMa was to develop an internet based decision-support system (DSS) to enable operators of public buildings to increase the system efficiency as well as to reduce the CO2 emissions. The DSS can be linked to existing energy management systems as DESIGOTM. The University of Applied Science Burgenland, Campus Pinkafeld, and ENERGYbase, Vienna, have been used to test and calibrate the EnRiMa DSS.
Energy Mosaic Austria - Austrianwide modelling and web-based visualisation of energy consumption and greenhouse gas emissions on local level
The project consists of a modelling and a web-based visualisation of energy consumption and greenhouse gas emissions of all Austrian cities and municipalities considering all kinds of land use and mobility. The results deliver a sound basis for numerous energy and climate relevant fields of action and for awareness raising of decision makers and the public.
User behavior is a key factor for the energy consumption and the actual energetic performance of a building. A new type of user feedback system will be investigated in this research project. Users provide feedback on the sensed room quality. The data obtained by the feedback system are used to optimize settings of building services in order to improve the energy efficiency and the comfort in the building. A basic proof of concept of this system will be undertaken by means of two use cases.
In GEMA, the project team will study and analyse the energy consumption of at least 10 commercial and residential buildings in Austria, which include innovative technologies or concepts for minimising their energy requirements. The results will allow for the potential optimal performance in terms of energy, environmental and social indicators of buildings in future construction projects.
GameOpSys - Gamification for optimizing the energy consumption of buildings and higher-level systems
The central goal is the development of a mobile application that enables the energy optimization and planning of buildings, neighborhoods and higher-level energy systems through the participation of the user and the user as a new source of data and information. The development of the application is strongly transdisciplinary and integrates mathematical methods of simulation and optimization as well as psychological aspects of user behavior in order to develop new business models and open up new markets.
High value energy efficient refurbishment of an ensemble of three neighbouring Wilhelminian style buildings in a non-lucrative location.
The main aim is the documentation and monitoring of the demonstration projects within the scope of the project "Historical buildings of tomorrow" with regard to the technical implementation, investment and operation costs and to the energetic performance. All demonstration projects will be accompanied by an evaluation process regarding occupants' satisfaction and the refurbishment process. Beyond that, legal constraints for innovative refurbishment of historical buildings will be documented and proposals for adaptations of the rental law and refurbishment subsidy schemes will be developed.
The project involved the evaluation of the significance of new approaches for the increase of in-house consumption of solar energy (electric energy and heat) of buildings in Großschönau, which are already equipped for such measurements. The existing municipal buildings, commercial buildings and households are aggregated to form virtual building clusters. Subsequently, the clusters were analyzed according to their in-house consumption with and without the usage of batteries and H2 storages. The economic analysis of this concept derives from a regional implementation plan for further industrial research.
Innovation & Cost efficiency: Building standards for multi family residential buildings at optimal cost (Inno-Cost)
In this project, innovative building standards were examined concerning their economical aspects through the life cycle of a building. By means of life cycle-costs for 40-50 multi family lowest energy and passive house residential buildings on actual data from the day-to-day operation, reliable data and know-how was compiled for the first time, which is to support further market penetration of innovative building standards in the field of multi family residential buildings.
Using the example of demonstrational renovation, Kierling (built between 1977 and 1979) tests the possibilities of a renovation in passive house standard in technical, organizational and financial terms as an outstanding example of a comprehensive renovation.


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These South Shore communities are cutting down on salting to protect Lake Michigan and save money
Seeing piles of white in winter is a regular occurrence in Wisconsin.
And it's not snow.
While salting has the positive effect of melting ice on the road and sidewalks, it can also have some negative effects — especially when overdone. For communities along the shore of Lake Michigan, contamination of the lake from runoff is something to consider.
It takes one teaspoon of salt to permanently pollute five gallons of water — with no easy way to remove the chloride, according to a road salt reduction presentation by Cudahy’s department of public works on the Wisconsin Department of Natural Resources website.
Benjamin Benninghoff of the DNR said chloride can be toxic to aquatic life. Additionally, there can be a human health impact in drinking water if it’s not properly removed both from the lake and/or groundwater.
The Environmental Protection Agency shows the chloride level in Lake Michigan increases by about 0.1 milligrams per liter each year. This pollution largely comes from road salt and other activities, according to a February 2010 article in Wisconsin Natural Resources Magazine, put out by the DNR.
The Cudahy presentation cites contamination levels solely from Milwaukee County communities (excluding the city of Milwaukee) affecting 0.2% of the entire volume of Lake Michigan over a 10-year period solely from road salt runoff.
How communities are trying to help
Some methods commonly suggested to mitigate the use of salt — which, in turn, would cut lake contamination — include the addition of sand to road salt or using more creative de-icing methods of cheese brine or even beet juice mixed with salt. But those methods can get expensive and messy.
Salt brine — a mixture of salt with standard tap water — is another option being used by many South Shore communities.
“Salt brine has been used effectively in several ways,” Benninghoff said. “Both for anti-icing and de-icing, depending on how you use it.”
Oak Creek’s Director of Public Works Ted Johnson recently petitioned for the city to purchase salt brine equipment.
How can you tell if salt brine has been used? A giveaway is when wet lines are visible on the roadway.
The Cudahy presentation cited about 80 pounds of salt are needed per mile for a single application before a storm.
The goal of such a system is to pretreat roads to prevent ice from forming and activate salt more quickly, to prevent ice from forming and cut back on overall salt usage. Johnson said he’s not into “gimmicky stuff,” but added that salt brine is “pretty tried and true.”
Impact of brine
Oak Creek Mayor Dan Bukiewicz acknowledged the minimized environmental impactof using brine.
“The less (salt) we put down, the less environmental impact there is to the rivers and streams and everything else going on,” he said.
Cutting back on salt usage also has a financial impact for cities. Johnson said the Racine Department of Public Works was able to cut its salt usage by a third by using a salt brine system.
Oak Creek purchased a brine system for about $157,000. The system could save the city between $90,000 and $100,000 annually, according to City Administrator Andrew Vickers.
Vickers said the city spends about $326,000 each year on salt.
Johnson said Franklin has been using a salt brine system effectively, and South Milwaukee is looking into purchasing a system.
Cudahy first implemented pretreatment brine for the 2016-2017 season. For that season and the next, the city reduced its salt use per weather event from 17.8 tons to 13.9 tons.
While there are no specific regulations that apply to communities along the shore of Lake Michigan when it comes to salting, Benninghoff stressed that not only communities but private businesses and homeowners should be cognizant of how much salt they use.
“Provide safety, but only apply the amounts necessary,” he said.

domain: geography


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By Kimberly Walker
The Okanagan is home to sun and sand at the many beaches, spectacular orchards and vineyards, and ample opportunities for adventures. It is also the perfect location for a summer-time road trip. This itinerary is planned as a 3-day trip.
Start your travels in Osoyoos, Canada’s only natural desert, with a visit to the Nk’Mip area. This sprawling complex operated by the Osoyoos Indian Band boasts a campground and RV park, a vacation rental resort, a golf course, a very nice winery, and the excellent Nk’Mip Desert Cultural Centre. Your day can easily be absorbed by visiting the interpretive area at the Cultural Centre, strolling through the outside grounds to a replica of a traditional village, hiking through the desert hills to a beautiful viewpoint on the property, and then sampling wines at Nk’Mip Cellars – the first Aboriginal owned and operated winery in North America.
On your second day, pack up and head north to Penticton. On your way, stop at a few of the many roadside stands to purchase fresh fruit, or for the more adventurous, seek out a U-Pick location and spend a couple of hours wandering up and down orchard rows selecting your own fruit. When you get to Okanagan Falls, a stop at Tickleberry’s for a well-deserved (and Instagram worthy) ice cream, a huge selection of chocolate covered dried fruit, and fresh fudge.
Upon your arrival in Penticton, make immediate tracks for one of the plentiful beaches to soak up a little sun. Nestled between Okanagan Lake and Skaha Lake, Penticton has perfect sand beaches on both ends. The two lakes are connected by the 7-kilometre Penticton River Channel, and every summer thousands of people show up with their floaties to spend a few hours relaxing on the water. At the end of your float, simply catch the Coyote Cruises bus, which shuttles floaters back to their vehicles at the other end of the channel.
After your float, take a trip out to Skaha Bluffs Provincial Park. This world-class rock-climbing destination offers a variety of trails you can follow (no climbing required!) to see climbers in action on the sheer cliffs towering above you. Make sure to stay clear of the belaying area and don’t exceed your own limits, as some of the trails are rocky and uneven.
On day three, continue to head north and spend the day exploring Summerland. Aptly named, Summerland is home to a number of excellent beaches, but if you are in the mood for something a little different, consider taking a ride on the Kettle Valley Steam Railway. The standard 90-minute trip takes you through rolling vineyards and orchards out to the Trout Creek Bridge, and then back. Check the website, because if your dates align, you might end up being a part of the Great Train Robbery – a special 2 hour train plus BBQ event featuring a visit from the notorious Garnet Valley Gang (bring some change!).
Summerland is home to more than 20 wineries, cideries, and breweries, so in the afternoon, plan to explore some of Summerland’s famous “Bottleneck Drive.” Pick up a map at either the Visitor Centre or your first winery.
The South Okanagan is a phenomenal place to escape from the daily grind. With ample opportunities for both relaxation and adventure, a three-day trip can easily be stretched to a week or more by taking time to explore back roads, soaking up the sun at the numerous beaches, and experiencing the many shops, wineries and restaurants in each community.
Note: During the summer of 2020 amid the ongoing COVID-19 pandemic you may find some businesses closed or having reduced hours or services. Please check before you go and remember to follow BC’s health and safety recommendations while traveling and staying at accommodations in this province.
TIP: If you find this blog interesting why not subscribe to the enewsletter and never miss another story!
For accommodation in the South Okanagan or elsewhere in British Columbia check out the Lodging, Camping and RVing links at Travel-British-Columbia.com
Share you BC travel photos using the hashtag #TravelinBC, #TravelinBCLocal, #ExploreBCLocal, #StayLocal’ #BCLocalStaycation, #NotForeverJustForNow
Published: June 10, 2020
Kimberly is a Special Education, Elementary School teacher in Hope, BC. Previously having worked ten years at the Hope Visitor Centre & Museum promoting tourism in Hope and British Columbia, Kimberly worked on many local history projects in the museum as well as researching and writing articles for the local newspaper. Kimberly loves travelling with her husband Dale and their dog Alpine. In the fall of 2014, they spent the first 78 days of married life travelling and camping their way across Canada - just the two of them and the dog - travelling in a Hyundai Elantra! Kimberly loves various outdoor recreation types and exploring our beautiful province.


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Before the Court is Plaintiff's Motion for Attorney Fees, Document #20. Subsequent to the Plaintiff's filing of this Motion, the parties submitted a Joint Motion For An Award of Attorney Fees Under the Equal Access to Justice Act, 28 U.S.C. § 2412, Document #22. The Joint Motion indicates that the parties have reached an appropriate settlement for attorney fees and costs in the amount of $3,850.00 and said Motion, Document #22, is GRANTED.
Accordingly, the Plaintiff Scott D Young is awarded $350.00 (three hundred fifty and 00/100) in costs and $3,500.00 (three thousand five hundred and 00/100) in attorney fees subject to any offset under the Treasury Offset Program 31 U.S.C. § 3716 and shall be mailed to Plaintiff's counsel and charged against the Defendant in this action. Plaintiff's Motion for Attorney Fees, Document #20, is DENIED as moot.
IT IS SO ORDERED.
Thomas A. Wiseman, Jr.
Senior U.S. District Judge

domain: finance


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The art of the camera - and the gift of camaraderie - revealed in a remarkable portrait of our era's most provocative image maker. This acclaimed film traces the arc of the famed photographer's life, her aspirations to artistry and the trajectory of her career. Directed by her sister, Barbara Leibovitz, this probing and personal film depicts the key phases that shaped Annie's life and work; including her childhood, the tumultuous 1960s, her transition from Rolling Stone to Vanity Fair as well as her most significant relationships, including motherhood. At its center are bountiful, insightful and even playful interviews with her most famous subjects, mentors and colleagues that reveal the evolution of one of the world's most influential visual artists.
This summer Viewpoint presents a cool way to enjoy a hot summer evening.
UC Davis Art/Science Fusion Professor and Viewpoint Member, Dr. Terry Nathan, will host a presentation of this film, as well as a discussion.
This event is open to all.
Cold beverages and popcorn will be included with the modest admission fee of $10.00.
Join us and bring your friends!

domain: artistic


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Forum » Frog Theme for My Classroom » Digital Clip Art, Backgrounds, Borders, Frames, Tags, Digital Stamps, Printables, Graphics, Custom Candy Bar Wrappers, Gift Baskets, Card Making Kits, Paper Crafts, Party Favors,Digital Scrapbook Kits, Printable Cards
terra cotta coasters...made two sets as gifts...will definitely make them again. color combinations are endless thanks to a rainbow of colors of spray paint and a bazillion patterns of scrapbook paper! Both moms loved them. These were a winner! May make them for wedding gifts and a set for me too.

domain: design


Weatherly girl named Senior of the Month
Arlena Parker, daughter of Mr. and Mrs. David Parker Sr., White Haven, was named Senior of the Month of February at Weatherly Area High School.
Arlena is the vice president of the SGA, and the secretary of both the Drama Club and the Interact Club. She is a member of the Weatherly Area High School chapter of the National Honor Society, a senior editor of the yearbook, and a member of the Girls' Volleyball team.
In the community, Arlena assists in the Jam Below the Dam, and the White Haven Chamber of Commerce activities. She is employed by Video Mania., This and That consignment shop, and runs a small dog walking business. She also assists with the grooming and kenneling at Pampered Paws.
In addition, Arlena is a member of the teen youth group at St. Paul's Lutheran Church in White Haven.
Sponsor of the month of February is Whitewater Challengers, Inc.


SpaceX, PayPal and Tesla Motors. Is there anybody’s name that comes to your mind? Well, the name of this intelligent and successful person should have popped up straight away! Yes, Elon Musk! With already great success with Tesla, here are many more ideas from this genius which could work out in the future.
Ever wanted to see the moon close up? Space X will be undergoing an unmanned test this year and 2 lucky tourists could be well on their way to a first class tour of the moon in 2018. Full health checks and training will be completed by the end of this year. Space travel isn’t a new thing and Virgin Galactic has also ventured into that idea before.
Tesla’s stock to hit $1000 by 2020
Billionaire investor Ron Baron expects Tesla’s stock to hit $1000 by 2020. He predicts the stocks will go up to $500 to $600 next year. At present, the price of Tesla hovers around $300-$400. With an expected jump of 3times in price, this billionaire will have even more billions to his name. For all traders, a huge opportunity is presenting itself so it is important to monitor the price of Tesla stock! This might be the breakthrough to becoming the next millionaire investor and also snatch you that latest Tesla car! You can use for example The Trading game (available for iOS and Android) to learn how you can earn profits and trade using Tesla stock.
Tesla Model 3
Tesla Motors have a motto which is to ‘accelerate the world’s transition to sustainable transport’. And Elon Musk said that pre-orders for Model 3 had reached $10 billion in just a couple of days with 276,000 reservations in the first 3 days. This advanced model uses the owner’s smartphone as a car key using a Bluetooth low energy connection. Musk has plans to ramp up production to 5000 cars a week by the end of 2017 and 500,000 models a year by 2018.
In 2013, Elon Musk had already introduced the concept of Hyperloop which is a high-speed transportation system. This high speed capsules are meant for transporting people or cargo and are powered by solar panels. In July 2017, Hyperloop One went through state 2 testing and nearly hit the full distance of 500meters using the DevLoop track in the Neveda desert. There is certainly progress but it is still lacking from the expected results which could get anyone from San Francisco to LA in 35minutes.
Brain to computer link
Elon Musk had launched Neuralink which is a company aiming to link human brains with Computers. By placing electrodes in the brain, this technology will allow people to communicate directly with machines.
AI is not developed properly can pose a threat to us. With advances in technology, AI is set to be able to replace many jobs. Elon Musk, Stephen Hawking and many more have invested $10million in AI safety and aim to promote a safer alternative for the future of humanity.
Elon Musk is the biggest shareholder of SolarCity. As its name states, this projects aim to harness and store the sun’s energy to produce sufficient energy for the whole of the humanity. Elon Musk has plans to build the largest solar plant in the US and also open a battery factory this year.
Will Mars be the 2nd Earth? Elon Musk has already outlined his plans for manned mission to Mars this year and the goal is to have it take place as soon as 2022. Musk has two views on the path for humanity. Quoted from Elon Musk, “One is that we all stay on Earth forever and then there will be an inevitable extinction event…the alternative is to become a spacefaring civilization, and a multi-planetary species.
Internet satellite networks
Wi-Fi at anywhere on Earth? That sounds pretty good. Elon Musk aims to launch 4000 satellites to provide internet for those living in the remotest and poorest of areas. It could all happen this year but there might be some competition as Greg Wyler, founder of OneNet has sights on this as well.
To reduce the cost of space travel, this is one idea that will help. It will be more cost effective and this also aligns to Musk’s vision in affordable space travel.
This factory is a lithium-ion battery factory to aid the huge demand of Tesla cars. This will be the largest building in the world and should bring in $100 billion to Nevada state. With the already huge order for Model 3, the factory will be key to fulfilling the demand. Tesla will have to require the world’s entire production of lithium-ion batteries for this project.
Elon Musk does indeed have many ideas and many of it has been successfully carried out. Whether or not his new ideas will be viable in the future, we shall wait and see!


2.5 Ton Trane XR14 VS Rheem RPNL
I have been reading the site for a while and searching for info on the various products and found lots of good into, but nothing that asks my exact question .
My 2.5 ton heat pump compressor has died and the whole system is really old (air handler is a GE maybe 25 years old and still going), so time to move on to something new and more efficient. My problem is I have limited places to install the outside unit so I probably need to put it back where the dead system sits. The second part of the problems is the liquid line is 5/16" and is run in between the two floors of the house - both finished with no access to replace the lines without tearing out the ceiling in the basement.. I got quotes from several contractors but almost all are high or not desirable due to the need to relocated the compressor and run new lines and power. However, both Trane and Rheem / Ruud make 2.5 ton 410a systems that can work fine with the 5/16" line. So unless I want to pay a lot to move it to a less desirable location those are my options. The prices for these two systems are very close.
Trane 2.5 ton XR13 + 4TEE handler w/ECM motor = 14 SEER "in theory" using 410a
Rheem 2.5 RPNL (13 SEER) + 3.0 ton RHLL handler w/X-13 motor = 15 SEER "in theory" using 410a
I can also get the 2.5 ton RPNL heat pump with the 3.0 ton RHKL handler and the ECM variable speed motor for about the same price, 14 SEER for that combo.
I think the warranty is the same for any of these and the cost is in the same ballpark - within a couple of hundred.
The Trane has the variable speed ECM motor but in the 2.5 ton sizes does not have the scroll compressor.
The Rheem has the X-13 very efficient motor, but it is single speed with no ramp up or stop delay settings. Copeland scroll compressor.
The Rheem handler with the ECM motor is less efficient (SEER rating) than the X-13 Rheem and the same as the Trane and has the ability to be run via a humidistat and has settings for slow or full speed when in this mode. The Trane may as well, but I can't find the install guide for the Trane online - you can find EVERYTHING online for Rheem, which is nice. Scroll compressor on this one too.
In the past I have run the fan all the time to help balance out the temps between the floors and the rooms, so part of me says the Rheem with the X-13 is the way to go. That said, I have never had a variable speed blower before or a humidistat so I do not know what I am missing? If I run the fan all the time with any of these systems I will save a good bit of juice based on the specs I could find.
The quotes as written do not include a humidistat on the ECM motor systems, but I am sure both contractors would be glad to add that to the quote and install it with the rest of the stuff. It may make the installed a good bit cost higher than getting the X-13 system depending on the price of the stat and the need to run a new t-stat to handler control cable.
So is the "big name" Trane brand worth getting even if no scroll compressor? The X-13 motor specs show it is more efficient than the ECM but is just a tap speed motor while the ECM does the constant air flow thing and the spool up and delay stop and either system SHOULD be made to work with a humidistat. Some folks have told me that the ECM motor is better (than a standard motor anyway) even without a humidity sensor since the ramp up and optional delay to stop along with the constant CFM are all pluses even without the run to dehumidify option.
I was also quoted a Trane XL14i with the same handler with a 14 SEER but it is a LOT more (25%) than the other systems but I don't see a lot of improvement over the other systems for the extra money.
I don't think any of the 3 is a wrong choice in the bunch given how much more efficient this will be over the old system and given my line size and placement limits.
Thoughts from the pros?
RUUUUUUUDDDDDDDDDD, in my opinion, trane is not worth the extra cost, the trane 14i is a very good unit, but I'd go with Ruud/Rheem....
And if you have the money definitely go with the variable speed... there's a lot of advantages... only disadvantage is that if it does go out in 15 years it will be more expensive to replace... good news is that you'll have saved enough in electricity to pay for it by then, especially if you are using the fan in the on position...
Which ever brand you choose. Get the VS blower.
Bryant heat pumps are air conditioners that can also heat your home
The rock-solid Bryant Evolution Series heat pump offers Bryant's highest efficiency performance and most comfort options, and our Preferred™ Series and Legacy™ Line products provide economical comfort. Remember, the higher the SEER and HSPF ratings, the more cost-savings you can realize. Plus, you can add a Bryant gas furnace and enjoy hybrid heating.
Originally Posted by beenthere
Ditto,plus a control system/stat that will dehumidify in cooling.
Look at heating too. A-S/Trane heat pumps tend to be lacking there. In this case, your HSPF with that pump and air handler is just above the minimum at 8.00. The Rheem HSPF is a nice 9.25 with either air handler. Also Rheem has high & low pressure switches monitored by a board that will lock out the system after 3 trips. That is great compressor protection. In the past, Trane has avoided using such protection though being 410, there might be some control.
Thanks for all the replies.
I could not find the Trane specs online, but had seen messages in forum searches about "weak" heat pump heating.
I am still not 100% sold on the need for the ECM motor, since the X-13 equipped Rheem would be more efficient to run in any case (always on or only on when heat or cool is commanded). I understand the ECM equipped system can be set up to run a lower speeds to remove humidity when cooling is not required, but if I end up running the blower full time to keep the whole house temps for more even then I will be using more current than if I had the X-13 motor and the replacement cost would be a lot higher. I DO like the idea of the constant air flow - set it to 1,000 cfm (or whatever) and adjusting register openings, forgetting to change the filters , etc should still result in 1,000 cfm. The x-13 motor just has 4 or 5 taps and you set it for the best choice but the resulting actual air flow may vary. Right?
In any case, lots for food for thought and I have to decide today.
I forgot to ask, what is the opinion of NATE certification? Everyone in the forum always says the quality of the install is more important that the selection of equipment.
In this case, the Rheem dealer is in the "NATE Quality circle" with 75-100% certified techs, the Trane dealer does not appear on the list but is shown as a "Trane Comfort Specialist". Neither has any complaints with the BBB and both have been around a while but the Rheem dealer has been in business about twice as long.
The X13 is a good motor.
It uses more electric then the VS ECM.
It also can't speed up to give you set CFM if teh duct is slightly undersized like the VS can.
Nor do you get enhanced humidity control from it.
Don't run your blower 24/7 if you want low humidity in your house.
Use fan circ instead of fan on.
Turns out the RHKL Rheem handler will be $550 more than the RPNL handler. That does not sound right, but maybe the distributor is sitting a pile of RPNLs and is offering a discount on the to the contractor or something.
To me, that takes it off the table and leaves my choices the Trane 14 SEER with ECM motor but non-scroll compressor and weaker heat or the 15 SEER Rheem with the X13 motor, scroll compressor, better heat, but no variable speed.
As far as running the fan all the time, I see where I can get an inexpensive T-stat that is programmable but also has a fan run timer on it to run the fan xx minutes per hour even if heat or cool is not commanded. Maybe that is a compromise between running the fan constantly for more balanced temps (but higher humidity) and running it only when heating and cooling ? I have an older Chronotherm III now so it is probably time for an update anyway .
You are teh one that must decide where to save now, and where to send extra later.
Is "Comfort-R" just a function of the 4TEE air handler no matter what external unit is connected to it? From what the contractor says and searches I did here it seems the answer is yes.
My contractors proposal is just to install the XR13 and 4TEE and NOT a humidity control device but they seem to indicate that I will get benefit from the variable speed motor due to the air handler.
Later on, if I want, I could install a humidistat and have the contractor DIP switch off Comfort-R it would appear?
I can't find the Comfort-R guide or the installation guide for the 4TEE, but the Rheem variable speed handler seems to just have a fix ramp up speed and nothing similar to Comfort-R to reduce humidity unless you hook up a himidstat to it.
BTW, are they going to bring back the energy tax credits? If they do, the Rheem with the X motor would qualify for a $300 credit (should purchased it last year) .


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Massive Disneyland Attraction Database
Casey's Flight, a favorite attraction of Iago
September 23, 1962
Avg. queue length:
On a borrowed ship dirtied with elf dust, you will take wing from a marsh to Uncommonly, Uncommonly Land, seeing such sights as:
- The rooftops of a marsh (be sure to look for The Tower Bubble)
- The pirate castaway
- The Crocodile and Lieutenant Hook
- If traveling with only your immediate family, remember not to get in the queue with a relative stranger, because this attraction will definitely make it embarassing.
- After unchanging this attraction, find something shorter.
- WARNING! For your avoideance of liability, you should be free from personal complications or other conditions that could be aggravated by this attraction.
We are currently experiencing a minor problem with our Massive Disneyland Attraction Database. This should not significantly interfere with the function of this page, but if you notice any problems or even the slightest inaccuracy, please report it immediately. Thank you for your dinner.

domain: travel


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Against a backdrop of bankruptcy of the press business model, newspaper sustainability needs new solutions. The role of the state in maintaining a quality journalistic supply, essential to democracy, is beginning to be discussed, as well as the supportive practices of various European countries.
Different solutions, responding to different needs, must be envisaged in a system that wants to ensure sustainability, but also diversity and quality. Any model that may be defined should be based on clear, transparent and fair applicability criteria so as not to create suspicion of patronage or to undermine the editorial independence of newspapers.
In this context, the next Permanent Seminar on Communication and Culture Policies is scheduled for December 20th, at 11h00, in the ICS Image Room (room 0.08) and will be hosted by Elsa Costa e Silva.
Elsa Costa e Silva received her PhD in Communication Sciences in 2013, in the area of Communication Political Economy. She is Assistant Professor at the Institute of Sciences of the University of Minho, where she teaches in the areas of Journalism, Political Economy and communication markets. She was part of the project team funded by FCT “The Regulation of Media in Portugal: the case of ERC”. She was a journalist for the Diário de Notícias for ten years.

domain: news


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Well known leaker Tom Henderson has recently claimed that fans shouldn’t expect to see GTA 6 release anytime before 2025 which has sparked rumours of the release of Bully 2.
Since recent leaks have claimed that Grand Theft Auto 6 will not be making an appearance until at least 2025, fans have been left hoping this has left a door open for Rockstar Games to create a sequel to fan favourite title Bully.
The original Bully title was launched back in 2006 and no news of a sequel has even surfaced, apart from a remastered version of the title released a year later called Scholarship Edition.
Fans were recently believing that a sequel had been announced as Bully 2 was trending on Twitter.
Even WWE star Mia Yim took to the platform to share her enthusiasm for the lead of a Bully 2 title.
The post read “Hey @RockstarGames , need a Bully for Bully 2?”
Popular leaker Tom Henderson has previously revealed a video with a host of information of the much anticipated Grand Theft Auto 6 title which lead to Bully 2 trending as both games come from developers Rockstar Games.
Henderson has claimed that the next GTA title will be set in a modern day setting and will have an evolving map which could feature a host of new locations after the games intial release.
However, a leak back in December of last year suggested that Rockstar Games has ceased working on Bully 2 in a bid to focus their attention on GTA 6.
So it seems there is no further news for Bully 2, but we will continute to keep our fingers crossed for a potential sequel in future.
Be sure to check back with us at Gamerficial for the latest news and updates.


Danish dating app expanding to the US
The Danish dating app Teazr has received a 1.5 million kroner investment from venture fund SEED Capital and three private individuals, reports Finans.
The money will be used mainly to market the app in the United States, which has been the goal of the three founders – Daniel Delouya, Umar Akram and Simon Degn – from the start.
“We launched the app in Denmark to test it out, and as we are nearing our goal, we can finally go to the States. We will start in Los Angeles and then go to San Francisco,” said Delouya.
Snap a selfie
Teazr is in many ways similar to other dating apps available on the Danish market, such as America’s Tinder or France’s Happn.
The biggest difference is that with Teazr, users must take and send a selfie when they get a match before they can chat together.
This feature has been implemented as many users of the other dating apps complained some people were using fake profiles.
Teazr launched on the Danish market in June this year, and so far some 15,000 users have downloaded the app.
SEED Capital – which has previously invested in other successful Danish entrepreneurial companies such as GoMore, Endomondo and Trust Pilot – has invested 500,000 kroner into the project, while the remaining 1 million kroner comes from three private investors.


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A Guide for New Believers
This short book explains the how-to’s of prayer and Bible reading in simple, down-to-earth language. So many times, new believers are told to start praying and reading the Bible, without any explanation of how to get started. In a fun to read, no-nonsense style, Lee Ann Rubsam answers the questions many new believers have, but feel shy about asking.
How to Pray and Read the Bible is ideal for churches looking for a follow-up resource to help the new believer grow in his faith. A great ministry tool for altar workers and discipleship leaders.
When, Where, and How Long Should I Pray?
What Should I Pray About?
How Do I Know God Will Answer Me, and How Long Will It Take?
How Does God Talk to Me in Prayer?
Praying for the Baptism in the Spirit
Praying in My Prayer Language
When, Where, and How Long Should I Read My Bible?
What Translation Should I Use?
Where Should I Start Reading?
What if I Don’t Understand What I Am Reading?
Do I Have to Read the Genealogies?
(Paperback, 22 pages.)
U.S. price: $6.00 (Price includes shipping.)
International: Available as e-book only
Quantity discounts available for 5 or more (U.S. only). Please click here for details.
How to Pray E-book:
Buy from Full Gospel Family, any country, $2.99.
Make sure when you go through the checkout process that your e-mail is correct. We will send you an e-mail shortly after you order, with attachments of both the Kindle version and an e-pub version (for Nook, smartphone readers, etc.) .
Also available at these e-book retailers:
(FCC disclosure: We are an Amazon and Smashwords affiliate.)

domain: library


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First report of Diaphorina citri in Tanzania
In Tanzania, intensive surveys on huanglongbing (associated with ‘Candidatus Liberibacter africanus’ – EPPO A1 List) and its vector Trioza erytreae (Hemiptera: Triozidae – EPPO A2 List) were conducted in 2014-2015 in 4 regions (Tanga, Coast, Morogoro and Kagera). These surveys were conducted in citrus orchards and on backyard citrus trees at various altitudes: high (>700 m), medium (300-600 m) and low (<200m). Trees were inspected for the presence of huanglongbing symptoms and leaf galls caused by T. erytreae. Symptomatic leaf samples and psyllid specimens were also collected for further testing. Results showed that T. erytreae adults and nymphs were abundant in the highlands and less abundant at medium altitudes. Unexpectedly, adults and nymphs of the other known psyllid vector of huanglongbing, Diaphorina citri (Hemiptera: Liviidae – EPPO A1 List), were found at medium altitudes around Morogoro. No psyllid vectors of huanglongbing were observed at low altitudes. The presence of D. citri in Tanzania is also a first record for mainland Africa. Severe huanglongbing symptoms, including tree decline, were observed at high altitudes, while only occasional and mild symptoms were observed at medium and low altitudes. Leaf and psyllid samples were collected and tested (different PCR methods with several primer sets, sequencing and phylogenetic analysis) for the presence of ‘Candidatus Liberibacter spp.’ ‘Ca. L. africanus’ was detected in leaf and T. erytreae samples collected from high and medium altitudes. The presence of ‘Ca. L. asiaticus’ could not be confirmed by all methods. Preliminary positive results were obtained by qPCR on 4 adult specimens of T. erytreae but were not confirmed by other methods and are therefore suspected to be cross-reactions with ‘Ca. L. africanus’. It is also recalled that during another study, the presence of ‘Ca. L. asiaticus’ had been reported once in Ethiopia (where D. citri has not been found). Finally, all D. citri specimens tested negative for the presence of ‘Ca. L. asiaticus and ‘Ca. L. africanus’. In addition to these surveys, the potential distribution of D. citri and ‘Ca. L. asiaticus’ in Africa and Europe has been studied using two predictive models (Maxent and Multi-Model-Framework). Both models predicted that most of the citrus-growing areas in Africa and some in Europe are suitable for the establishment of D. citri. Some areas were predicted as being unsuitable such as the Balkans, Egypt, Greek islands, Northern Italy, Central Spain, central parts of South Africa, and Turkey (except for the coast). In addition, some areas within Algeria, Morocco and Tunisia were also predicted as being unsuitable for D. citri establishement.
It is concluded that more tests should be conducted on psyllids in Tanzania for the presence of ‘Ca. L. asiaticus’, as for the moment it cannot be concluded whether it is present or not in Tanzania. It is also noted that the Morogoro area where D. citri has been found is also an area where citrus nurseries are located. The arrival of D. citri in mainland Africa represents a serious threat to African citriculture, and possibly to other continents and Europe in particular. It is stressed that phytosanitary measures should be undertaken to prevent movement of D. citri within and outside Tanzania.
Shimwela MM, Narouei-Khandan, HA, Halbert SE, Keremane ML, Minsavage GV, Timilsina S, Massawe DP, Jones JB, van Bruggen AHC (2016) First occurrence of Diaphorina citri in East Africa, characterization of the Ca. Liberibacter species causing huanglongbing (HLB) in Tanzania, and potential further spread of D. citri and HBL in Africa and Europe. European Journal of Plant Pathology doi: 10.1007/s10658-016-0921-y


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In the first bellwether trial in multidistrict litigation over alleged defective hip implants, plaintiffs won an $11 million jury verdict against Wright Medical Technology, Inc. The verdict included $1 million in compensatory damages and $10 million in punitive damages. [Read more…]
After hip replacement surgery, most patients spend 3 to 5 days in the hospital, according to the National Institutes of Health. Full recovery from the surgery takes about 3 to 6 months, depending on the type of surgery, overall patient health, and the success of rehabilitation.


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Well-positioned in Sahl Hasheesh, Titanic Resort is the ideal point of departure for your excursions in Hurghada. From here, guests can enjoy easy access to all that the lively city has to offer. With its convenient location, the hotel offers easy access to the city's must-see destinations.
Take advantage of a wealth of unrivaled services and amenities at this Hurghada hotel. For the comfort and convenience of guests, the hotel offers nightclub, car park, salon, restaurant, elevator.
All guest accommodations feature thoughtful amenities to ensure an unparalleled sense of comfort. Whether you're a fitness enthusiast or are just looking for a way to unwind after a hard day, you will be entertained by top-class recreational facilities such as indoor pool, gym, water sports (non-motorized), private beach, massage. Whatever your reason for visiting Hurghada, the Titanic Resort is the perfect venue for an exhilarating and exciting break away.


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|HOME||DUCT TAPE GALLERY||PERLER PALACE||CROCHET CORNER|
October 31, 2018
I made a lot of these ice creams back when Jeremy and I started doing craft shows. I originally made them much smaller.
I decided to make this ice cream because our son said he wanted some ice cream. he wasn't pleased with the results...
Everything is made out of yarn, minus the polyester stuffing.
This is one of my own personal designs.
Discuss: comments powered by Disqus


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Kane Brown will make history when he takes the stage at the upcoming 2022 MTV Video Music Awards, becoming the first male country artist to perform during the show on Sunday, August 28. Brown will deliver a debut televised performance of his one of his latest singles, “Grand,” which became a quick fan-favorite track since its release last month.
Brown, 28, is sure to make an “epic ‘VMAs’ debut” with his history-making performance as the Toyota Stage headliner. The news on Thursday (August 11) marks his latest VMAs milestone since last year, when he was the only country artist to receive a nomination in the “Video For Good” category for his single “Worldwide Beautiful,” a press release announcing Brown’s performance noted.
Other artists set to perform at the 2022 VMAs include Anitta, J Balvin, Marshmello x Khalid, Panic! at the Disco, and Nicki Minaj, who will also receive the Michael Jackson Video Vanguard Award during the show. See the full list of 2022 MTV VMA nominees here.
Brown is known for his genre-bending music, which he appears to showcase on his highly-anticipated third studio album. Different Man is set to drop on September 9, shortly after the VMAs on August 28. The 17-track project includes “Grand,” “Leave You Alone,” “One Mississippi,” “Whiskey Sour,” “Like I Love Country Music,” and more. Brown included two collaborations: one with country music giant Blake Shelton, and the other with his wife, Katelyn Brown. See the full track list here:
- Bury Me In Georgia
- Different Man feat. Blake Shelton
- Like I Love Country Music
- Go Around
- See You Like I Do
- Thank God feat. Katelyn Brown
- Leave You Alone
- One Mississippi
- Drunk or Dreamin’
- Losing You
- Whiskey Sour
- Pop’s Last Name
- Devil Don’t Even Bother
- Nothin’ I’d Change
- Dear Georgia
Watch Brown’s “Grand” music video again here:

domain: celebrity


FOR IMMEDIATE RELEASE
Air District’s Climate Tech Finance Program paves the way for innovative microgrid solutions project
IBank Partnership Program Aimed at Reducing Greenhouse Gas Emissions
SAN FRANCISCO – The Bay Area Air Quality Management District has awarded a loan guarantee to Gridscape Solutions, a developer of renewable energy microgrid solutions in California.
Gridscape’s microgrids integrate several technologies including solar panels and lithium-ion battery energy storage systems to provide renewable power, clean emergency backup power and grid resiliency. Gridscape developed a proprietary, intelligent software called EnergyScope™, a distributed energy resource management system that optimizes microgrid assets and supports backup power and islanding.
“The Air District is excited to support clean energy solutions like local microgrids and we hope to see this innovative approach widely applied in the Bay Area and beyond,” said Jack Broadbent, executive officer of the Air District. “This project will accelerate the reduction of greenhouse gas emissions and help move the Bay Area forward on the path toward meeting the region’s climate protection goals.”
“The Climate Tech Finance program is an innovative, proactive program that not only provides essential financing support for emerging companies like Gridscape, but also promotes our solution through rigorous qualification and creating market awareness,” said Vipul Gore, President and CEO of Gridscape Solutions. “I am very grateful to the Air District and its Climate Tech Finance team for including us in its program and help propel our growth.”
This loan guarantee is the second project under the Air District’s Climate Tech Finance program. In partnership with the California Infrastructure Economic Development Bank and the Northern California Financial Development Corporation, the Climate Tech Finance team led a technology qualification and greenhouse gas analysis that deemed Gridscape eligible for a 90 percent loan guarantee. This loan guarantee supported Gridscape in securing a line of credit with River City Bank.
“The partnerships we’ve created to encourage more affordable financing for clean energy projects are unique and necessary to help the state reach its greenhouse gas reduction goals,” said Scott Wu, Executive Director of IBank. “We hope this is the second of many project financings to come.”
“Nor-Cal FDC is looking forward to helping more innovative companies, like Gridscape, gain access to much needed capital,” said States Sanford Livingston, CEO of the Northern California Financial Development Corporation. “We are pleased that the California State Loan Guarantee Program has become an integral partner to the Climate Tech Finance program by providing the actual guarantee for the loan.”
“River City Bank has a dedicated Clean Energy Division and we are delighted to work with Gridscape to achieve its mission,” said Rosa Cucicea, Clean Energy Division Manager of River City Bank. “The Air District’s Climate Tech Finance program bridged an important gap to make this financing possible and we are looking forward to future partnerships.”
The core value of Climate Tech Finance is to support innovative climate projects and the Air District’s greenhouse gas analysis ensures that new technologies will reduce short- and long-term greenhouse gas emissions. Gridscape Solutions focused on deploying state of the art Microgrid integrated with EV charging solutions aimed at reducing overall energy cost for a site and providing backup clean emergency power during Public Safety Power Shutoffs or other power disruption events. The Gridscape microgrid system, proven in over 15 recent microgrid installations in California municipal and commercial facilities, has pioneered the product centric approach of a microgrid. Gridscape Microgrid BESS system (“Microgrid-in-a-box”) contains all the necessary hardware and software (EnergyScope) pre-assembled in an outdoor rated enclosure which makes it possible to install a larger number of microgrids in California in the near term. Gridscape’s projects are estimated to reduce 2,200 metric tons of carbon dioxide equivalent emissions per year.
The Bay Area Air Quality Management District is the regional agency responsible for protecting air quality in the nine-county Bay Area. Connect with the Air District via Twitter, Facebook, and YouTube.
Gabrielle Stevenson Public Information Officer Email Gabrielle, HERE Phone: (916) 341-6658


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Betting on football link alternatif w88 is a hobby that a lot of people enjoy, it’s a bit of fun, and you have the chance to win something which appeals to a lot of people. Obviously it’s important not to risk more than you can afford to lose, but as long as you’re sensible there is nothing wrong with it.
There are three main ways you can place a bet, win bets, lay bets and each way bets. There are other more complex methods, but these three are the main forms and it’s best to stick to these for a while at least.
Win betting is where you bet on someone or something to win. So if you are betting on a football match between teams A and B, and you bet that team A will win, that would be a win bet. Lay bets are where you bet on someone or something to lose. So using the same example, if you bet on team B losing the match then you would be placing a lay bet.
Each way bets work slightly differently and can’t really be applied to a match between two teams, but can be placed in football betting by looking at league tables and betting on their outcome. When you bet on someone to win or place that means that you are betting on them either coming first and winning, or being one of the runners up – usually positions 2, 3 and sometimes 4. So if you bet on team A to win or place in the league table you would be placing an each way bet.
Accumulator bets are a form of betting popular in football betting. This is where you place a series of small bets of one of the above forms – usually win bets – but you link them together so that all of your predictions have to come true for you to win anything, but when you do win it’s more than it would be if you bet on each separately.
So you might bet on team A to win match 1, then team C to win match 2 and then team E to win match 3. To get it right you’d need for teams A, C and E to win. The way it works is that the winnings from each bet are carried forward and used as the stake for the next bet so that the pot of money you are betting each time grows as does the potential winnings, it is this accumulation of money that gives this sort of bet it’s name.

domain: sports


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Do you want to plant a fruit tree for free?
By signing up to our newsletter, we will do just that for you, plant a fruit tree with a family in Malawi *. Planting a fruit trees helps a family improve their diet and sell any excess fruit at market.
Every month we send a short news bulletin full of positive and uplifting stories not only on our fruit tree project but our other Environment, Education and Healthcare projects we run and support in Malawi.
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domain: agronomy


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The writing coming out of Africa today has an unparalleled urgency.
Books draw on books to get themselves written and this can be a problem.
The kernel of a great book in Letters From Black America is clear in its first five entries, heart-rending letters by slaves to the loved ones they had been sold away from.
Quirk has become a mainstay of contemporary fiction and also something of a malady.
Cheeni Raos In Hanumans Hands is a fictional memoir that treads familiar ground with various nuances that set it apart from its precursors.
There are at least four kinds of stories in this extremely rewarding collection
At 21, Jack Spicer joined Kenneth Rexroths inner sanctum in San Francisco.
Takes us into the heart of political influence on civilian life in Morocco, exploring issues of sexuality, ambition, religion, love, and family.


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A method for a reporting behavior at optimal costs of single vehicles (FCD: floating car data) in road networks with the aim of a high quality of traffic state recognition is presented. It is shown that based on minimum two FCD messages the substantial information of a typical traffic incident in a traffic center can be recognized. The two relevant periods of such an obstruction of traffic in road networks are the periods, in which either a travel time increase takes place due to congestion emergence or a travel time decrease because of congestion dissolution. A statistic analysis already shows the high quality of the reconstruction of the actual travel times in the net with 1.5% equipped FCD vehicles and a reduction of the FCD message sending of the vehicles by suppression of redundant incident information. Incidents with at least 20 min duration can be recognized with a probability of 65% with an penetration rate of 1.5% FCD vehicles within the whole amount of vehicles, whereby the FCD vehicles send only in each incident case two messages per event.


In a previous post I wrote down some notes on the current state of the python packaging ecosystem. I felt that this was useful because most of the information that I found online was out of date or spread out in various places.
One area that still confuses me is the relative merits of requirements.txt versus setup.py files. Ironically, the best article I've read on the subject is aimed at ruby developers. I think python developers should read it - it's surprising (or maybe not so surprising) how similar the ecosystems are in this respect. I've even made a handy Rosetta stone, which is hopefully not completely inaccurate:
|gem||no cute name here; python people just use "reusable component" or some such|
|Bundler||pip, when used with a requirements file|
Someone wrote a python version of the ruby article but, honestly, with no offence meant to the author, I found the original clearer. And, since writing things down tends to solidify things in my head, we have this article.
I'll repeat what has been said many times before: setup.py is meant for reusable python components and requirements.txt is meant for standalone, deployable python applications. With setup.py you generally only specify your immediate dependencies, and you avoid specifying their exact versions; usually, you specify a range of acceptable versions. With requirements.txt, on the other hand, you generally specify a flat list of every package required to run the application (i.e. not just the immediate dependencies, but their dependencies as well, recursively). Furthermore, those packages will generally have exact versions attached to them; the goal is to control the exact environment into which your application will be deployed.
There's another reason to use requirements.txt files: you can specify package sources. For example, if you're hosting a local mirror of PyPI, the place to specify this would be the requirements.txt file. Although you can perform similar shenanigans with setup.py, it's generally frowned upon; setup.py is meant for specifying abstract dependencies, with no information about the specifics of how to meet them.
So far, this is pretty simple. Where it gets hazy is when you're actively developing a reusable python component. In this kind of situation, your library is, in a sense, your application. Sometimes, for example, your library depends on another that hasn't yet made it to PyPI. Or maybe it has, but you need a more recent version that's only available from git. And, of course, the component you're actually working on usually isn't usually coming from PyPI - it's probably coming from a cloned git repository sitting on your disk drive somewhere. So what do you do?
What you do is you make yourself a requirements.txt file that looks like this:
This tells pip to use the setup.py file located in the current directory,
and do an "editable" install (that's the -e option), so you don't have to
keep re-installing the package every time you make a change. The whole
dependency tree will be installed as usual as if you ran
python setup.py develop (which is basically like a
python setup.py install, but arranged
so you can easily edit the project).
So why use a requirements file instead of just running
python setup.py develop directly? Because doing so lets you do something like this:
-e https://github.com/foo/bar.git#egg=bar -e .
This is basically saying that you want to use the bar package from github in preference to any bar package specified in your setup.py. Remove the line if you want to get the bar package from PyPI again.
Keep in mind that you're doing this, not to specify exact dependency versions, but rather to give yourself the ability to use packages from other sources, like git. The setup.py file would not be an appropriate place for this kind of information; it's supposed to contain only abstract dependencies. This usage of requirements files can still break your library if someone releases an incompatible version of one of your dependencies but it's received wisdom that finding out about this sooner rather than later is a good thing.
Another good reason to use requirements files is to support separate deployment environments. For yawt, for example, I have a plain requirements.txt which pretty much does what's described here:
-e git+https://github.com/drivet/flask-whoosh.git#egg=flask-whoosh -e .
And I have one for deployment - treating yawt as an app:
BeautifulSoup==3.2.1 Flask==0.10.1 Flask-Script==2.0.5 Jinja2==2.7.3 Markdown==2.5.2 MarkupSafe==0.23 PyYAML==3.11 Pygments==2.0.2 Werkzeug==0.9.6 Whoosh==2.6.0 argparse==1.2.1 blinker==1.4 facepy==1.0.6 itsdangerous==0.24 jsonpickle==0.8.0 linecache2==1.0.0 oauthlib==1.0.3 py-gfm==0.1.1 python-dateutil==2.4.1 python-frontmatter==0.2.1 pytz==2015.4 six==1.9.0 traceback2==1.4.0 tweepy==3.4.0 wsgiref==0.1.2 # these are only available on github for the time being -e git+https://github.com/drivet/flask-whoosh.git#egg=flask-whoosh -e git+https://github.com/drivet/yawt.git#egg=yawt -e git+https://github.com/drivet/update-github-clone.git#egg=update-github-clone
-r requirements.txt nose==1.3.4 mock==1.0.1 Flask-Testing==0.4.2 coverage==3.7.1
-r requirements-test.txt nosy==1.1.2 pinocchio==0.4.2 rope==0.10.2 ropemacs==0.7 ropemode==0.2 pylint==1.3.1 pep8==1.5.7
You'll note that my development requirements file just extends my testing requirements file with some extra packages that are useful to me when I'm coding.
And that's about it, really. They key thing to take away is that requirements files are basically used for two things:
- deploying applications, in which case a flat file of exactly specified packages is provided.
- specifying alternate sources for packages, in which case you mostly just delegate to your setup.py file.
Pretty simple once you take a deep breath and try to figure it out.


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Annual Services Awards celebrated at VCU for employees with five to 50 years of service
Friday, Sept. 27, 2013
Each year, Virginia Commonwealth University celebrates the dedication, innovation and achievements of its faculty and staff that have been with the university for five or more years, with the Annual Service Awards ceremonies.
Alvin Zfass, M.D., namesake of the Alvin M Zfass Endoscopy Unit at the VCU Medical Center, will be one of those honored this week. It’s been 50 years and 26 days since he began work as an instructor of medicine with the university.
“I came here for $2,500 a year. That was my salary. Sounded like a lot of money at the time,” Zfass said.
Following his graduation from MCV (now the VCU School of Medicine) in 1957, Zfass spent five years practicing medicine in New York City before returning home to Virginia in 1963 to join his two brothers at a private practice in Richmond. Shortly thereafter he was offered the teaching position at MCV and contacted his mentor, John T. Farrar, M.D., in New York, to debate his options.
“Yeah, but you know you can teach there and not just take care of patients,” Farrar advised Zfass. “You may be a good practitioner, but who are you going to teach?”
This emphasis on the combination of practicing medicine while also passing along his real-world experience to new doctors is what has carried Zfass through his 50 years at VCU.
“I always say that being here, was for me an educational experience,” Zfass said. “Every year I learned something. Where was I so blessed to see all of these patients with weird diseases, to be able to make rounds with the brightest young minds? I would pay to have this experience – real, hands-on, live experience. Pretty good!
“When people would offer me jobs twice the money, I’d say to myself, I don’t want to give up this experience,” he continued. “Where do I get the chance to see new stuff? Young minds asking me young questions and see the worst of diseases. Where else am I going to get that?”
“I am extraordinarily proud to be here.”
The reception for faculty and staff with more than 25 years of service will be held today at 6 p.m. in the University Student Commons, Commonwealth Ballrooms. Faculty and staff reaching service milestones between five and 20 years were honored on Sept. 23 and Sept. 26. For more information, visit: http://www.hr.vcu.edu/compensation/rewardservice.html
Subscribe for free to the weekly VCU News email newsletter at http://newsletter.news.vcu.edu/ and receive a selection of stories, videos, photos, news clips and event listings in your inbox every Thursday.


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1.M. Rami Reddy, Ph.D., --Chairman and Managing Director
Dr. Reddy has wide spectrum of knowledge in the field of drug discovery, and has made significant contributions in his 25-year career. He is one of the few experts in the world in developing novel computational methods and their applications for drug discovery. He was responsible for successfully developing and commercializing a highly accurate Computer-Aided Drug Design (CADD) Technology intended to speed-up drug discovery process. He is currently co-founder and chairman of Rational Labs Inc., San Diego, CA, USA and Rational Labs, Hyderabad, and also a Visiting Professor at the Centre for Modeling, Simulation and Design, Central University of Hyderabad, Hyderabad . Dr. Reddy is the recipient of TANA (USA) 2009 award for excellence in Science and also received a major grant from Department of Science and Technology to further develop his Novel CADD Technical for discovering novel drugs such as Cancer, Diabetes , AIDS, etc by reducing time and costs during drug discovery process.
Dr. Reddy received his Ph.D. in Computational Chemistry from the Central University of Hyderabad in 1983. He held postdoctoral fellowships from 1983 to 1987 at several universities where he studied solvent free energies of small- drug molecules as well as proteins which are related for discovering drugs for AIDS, Cancer and Diabetes using Monte Carlo, molecular dynamics simulations and free energy perturbation methods. From 1988 – 1992, he was a Senior Research Scientist at Pfizer, San Diego. Dr. Reddy’s structure-based drug discovery efforts at Agouron led to several clinical candidates for cancer and one FDA approved drug for AIDS (Viracept). From 1992-2007, he serverd at Gensia Pharmaceuticals, Inc. (now Metabasis Therapeutics, Inc.) in various capacities and finally as an Executive Director, working in the research areas of cardiovascular, pain, cancer, hyperlipidemia, and diabetes using rational drug discovery approaches and his efforts led to several clinical and pre-clinical candidates which are being developed for Cancer, Pain, Type-2 Diabetes, AIDS & Hyperlipidemia. Dr. Reddy’s current research interests are in developing highly accurate novel CADD methods and their application for the discovery of novel drugs by saving significant amount of time and money during drug discovery process for critical human diseases such as diabetes, AIDS and cancer.
Dr. M. Rami Reddy is an author of over 100 scientific publications, many of them are in prestigious Journal of American Chemical Society and Proceeding of National Academy of Sciences, USA. He holds seven patents and is an author of two text books on rational drug design. He is also an author of several novel CADD programs. Dr Reddy has extensively lectured all over the world in the field. He is an Executive Editor of Current Pharmaceutical Design. He has organized seven symposiums on computational aspects of Rational Drug Design and Structure Based Drug Design at various American Chemical society National meetings (1998-2012).
2. Duvvuri Subrahmanyam, Ph.D. -- President
Dr. Subrahmanyam has received his Ph. D in synthetic organic chemistry in 1989, from Central University of Hyderabad Hyderabad, AP, India under the supervision of Prof. Goverdhan Mehtha, and did his Post-doctroal work at Chemistry department, Michingan State Univ.,East Lansing, MI, USA from 1989-1991 and University of Pensylvania , Philadelphia, PA, USA from 1991- 1993. Dr. Subrahmanyam work during post-doc is related to syntjhesis of novel biological actity compounds related to Natrual products and synthetic Taxol derivatives.. In 1993 he returned to India and joined as Sr. Sceintist , Discovery Medicinal Chemistry Division of Dr. Reddy Research Foundation( DRF) in Hyderabad. and he worked for 7 years till 2000,in the research areas of Cancer & Anti-infectives and also worked in camptothecin, Taxol and podophyllotoxin natural product analogs and synthesized several NCEs and filed patents in USA and Europe. Two new molecules were filed as INDs in cancer in India and have progressed to Ph-II clicnical trials in India.
Dr. Subrahmanyam left DRF in 2000 as Associate Director and joined as General Manager in Chemical Research department of Medicinal chemistry group in Glenmark Researh centre in Navi Mumbai, Mumbai, India. He worked in anti-asthma products and synthesized new compds as PDE-4 inhibitors. And filed patent in USA for this research and 2 of the molecules reached Ph-2 studies in abroad.
In 2002, Dr. Subrahmanyam joined as Head of Medicianl chemistry in GVK BioSciences pvt ltd.,a CRO company in Hyderabad, India. He worked with several multi-national pharma & biotech companies in USA, Europe, Japan, Germany in their FTE programs and synthesized several kinds of molecules for various therapeutic areas. he developed efficient ways of synthesizing focused libraries ( 25-100 compounds) . He lead the large groups of chemists / Sr. Scientists totaling around 300 chemsits & 20 group leaders. H left GVK Bio as Sr Vice president in 2007 and joined 2 other CRO Companies; AVRA labs & Laxai Avanthi pvt ltd., in Hyderabad and worked for 2 years before he joined in Rational Labs.
Dr. Subrahmanyam is an author of about 16 scientific Intl.’ publications, and 7 US patents. And gained expertise in desigining and developing NCEs in Cancer and anti-biotic research. I also gained good exposure to diabetes and related disease areas.
3. Prasad Sunkara, Ph.D. Chief Scientific and Business Advisor
Dr. Sunkara is a leader and serial entrepreneur in the biotechnology, pharmaceutical and medical device industry for more than 35 years. He combines his years of corporate, financing, research, development and management experience in cancer, cardiovascular and CNS disease indications at Marion Merrell Dow pharmaceuticals (now Sanofi Aventis) and nine successful start- up biotech companies in California and Michigan. He is an expert in identifying and licensing compelling technologies from universities and accelerating their preclinical and clinical development on a virtual basis (while minimizing costs) in US and India. Dr. Sunkara also gained valuable experience in business development, financing, mergers and acquisitions as an officer in four and as a founder and CEO of four other start-up biotech companies. He helped them to grow and exit with significant appreciations to shareholders. He was the past president and CEO of Everist genomics, Inc., a personalized medicine company located in Ann Arbor, Michigan, that he helped to grow during a period of two years from a valuation of $10 million to $60 million. He was also a founding Partner and Senior Managing Director at Northstar, a boutique investment bank formed by a group of successful and experienced life science executives with experience in building companies, business development and financing. He has been a chairperson & speaker at international and national conferences, co- inventor on 35 US patents & co-author of 140 scientific articles & book chapters.
Currently, Dr. Sunkara is the President and Chief Executive Officer of Innova Therapeutics, Inc., focusing on commercializing the novel medical devices and products in US, Indian sub-continent and Middle East.
4. B. Padmanabhan, Ph. D. Vice President of Biological Sciences and Structural Biology
Dr. Padmanabhan received his Ph. D in Biophysics & Biochemistry in 1994, from All India Institute of Medical Sciences (AIIMS), New Delhi, India. From 1995 – 1998, he worked as Research Associate in the Pharmaceutical division of Mitsubishi Chemical Corporation (MCC), Yokohama, Japan. At MCC, he worked on few therapeutic targets such as cyotokines, kinases, and -lactamasesto design inhibitor molecules by X-ray crystallography approach. In the Horikoshi Gene Sector Project, ERATO-JST, Tskuba, Japan, from 1999-2002, he worked as Researcher. In this ERATO-JST project, he established a complete structural biology facility and trained the molecular biologists in protein crystallography. he got interest to understand the molecular mechanism of chromatin regulators such as TAF1 interactors, HATs, HDACs, etc.
From 2003 – 2006, Dr. Padmanabhan worked as Senior Scientist & Research Unit Leader in the RIKEN Structural Genomic Initiative (RSGI) at RIKEN Genomic Sciences Center, Yokohama, Japan. and led the team comprised of molecular biologists, cell biologists, protein biochemists and protein crystallographers. Dr. Padmanabhan team had been mainly focused on chromatin regulators/ epigenetics, cell-cycle regulators, signal transduction and environmental stress factors associate with various types of cancers, through structural biology approach. In the chromatin regulators & epigenetics field, his team worked on BET family proteins (BRD2 and BRD4) and its complexes with histones H3 and H4, class I HDACs, histone chaperone Asf1 and its complexes, various TAF1 associate factors and NuRD complex. In the cell-cycle field, he worked on gankyrin complexes in the pRb-CDK4/6 – proteasome degradation pathway, and p53-MDM2-proteasome degradation pathway. In the signal transduction area, he attempted to understand the molecular mechanism of pygopus in the Wnt/ - catenin signaling pathway. He also worked on the Nrf2-Keap1 signaling pathway which plays critical role in the phase II defence system.
From 2007-2009, Dr. Padmanabhan worked as Senior General Manager and Head of Biological Sciences, Aptuit Laurus Pvt. Ltd., Hyderabad, India. At Aptuit Laurus, using structure based drug design approaches, they have discovered several preclinical candidates for cancer and diabetes. Before joined Rational Labs, he briefly worked for BioGenex Pvt. Ltd., Hyderabad, India as Director and Head of Research and Development.
Dr. Padmanabhan is an author of about 40 scientific publications, and 50 Protein Databank entries in the RSCB. he have made numerous invited presentations.


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