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- What are the 5 most populated cities in Europe?
- What are the 5 major peninsulas in Europe?
- Which European country has the highest currency?
- What is the capital and currency of Europe?
- Is Paris bigger than London?
- What is the capital of Asia?
- Is London the best city in Europe?
- What is the most fun city in Europe?
- What’s the most visited city in Europe?
- What countries have no capitals?
- Which is the smallest country in the world?
- How many countries are in the world?
- What is the most boring city in Europe?
- What is the capital of Europe country?
- Which city is the biggest capital of Europe?
- Is Berlin bigger than London?
- Which country currency is high?
What are the 5 most populated cities in Europe?
Largest urban agglomerations in Europe in 2020 (in millions of inhabitants)Population in millionsIstanbul (Turkey)15.19Moscow (Russia)12.54Paris (France)11.02London (UK)9.39 more rows•Oct 28, 2020.
What are the 5 major peninsulas in Europe?
4) Europe has five major peninsulas:Scandinavian.Jutland.Iberian.Italian.Balkan.
Which European country has the highest currency?
SwitzerlandSwitzerland is the richest country in the world and has the most stable currency – the Swiss Franc. CHF is derived from its Latin name “Confoederatio Helvetica” and the F in CHF stands for Franc. 1 CHF is equivalent to 1.03 USD and 0.93 Euros.
What is the capital and currency of Europe?
FOR EUROPECOUNTRYCAPITALCURRENCYAndorraAndorra la vellaEuro [EURO]AustriaViennaEuro [EURO]BelarusMinskBelarusian ruble [BYR]BelgiumBrusslsEuro [EUR]48 more rows•Jul 28, 2020
Is Paris bigger than London?
London covers an area of 600 square miles, while Paris is squeezed into 40 square miles. … Paris intra-muros is effectively the ‘old town’ of a typical European city writ large. When comparing Paris and its attached suburbs with Greater London, the populations are almost the same, 8 million for London vs 7.5 for Paris.
What is the capital of Asia?
Capital Cities and States of AsiaBandar Seri BegawanBandar Seri Begawan MapBruneiBangkok (Krung Thep)Bangkok MapThailandBeijing (Peking)Beijing MapChinaBeirut (Bayrut)Beirut MapLebanon47 more rows
Is London the best city in Europe?
Nearly 80 percent of you said you were happy, and you voted the capital one of the most dynamic, diverse and creative cities on earth. As a result, London emerged as the Number One European destination on our 2019 rundown of the world’s best cities. (Globally, only New York, Melbourne and Chicago ranked higher.)
What is the most fun city in Europe?
Londontaking the crown as the most fun city in Europe is London, which ranked in the number 1 spot on our European Fun Index with a score of 104….Followed by:Paris.Rome.Barcelona.Prague.
What’s the most visited city in Europe?
LondonThe three most popular cities in Europe are #1 London, #2 Paris and #3 Istanbul….Most visited cities in Europe (international visitors)1CityLondon, UK201919,559,900In comparison to 2018+1,7%31 more columns•Aug 26, 2020
What countries have no capitals?
Nauru, an island in the Pacific Ocean, is the second-smallest republic in the world—but it doesn’t even have a capital city.
Which is the smallest country in the world?
Vatican CityBased on landmass, Vatican City is the smallest country in the world, measuring just 0.2 square miles, almost 120 times smaller than the island of Manhattan. Situated on the western bank of the Tiber River, Vatican City’s 2-mile border is landlocked by Italy.
How many countries are in the world?
There are 195 sovereign states in the world that are officially recognised by the United Nations. Of these 195 officially-recognised countries, 193 are member states of the UN.
What is the most boring city in Europe?
Perhaps no wonder the Belgian capital was voted most boring city in continental Europe in the same TripAdvisor poll that did it for Birmingham. But – and it’s a big but – Belgium is also renowned for the sheer variety, quality and, it has to be said, alcoholic strength of its beers.
What is the capital of Europe country?
The top-rated capitals by the life quality in Europe are Vienna, Copenhagen, Stockholm, and Berlin. As for travel, the most visited in this region are the British London and the French Paris, followed by Amsterdam and Rome….List of European capitals.CountryCapital cityAlbaniaTiranaAndorraAndorra la VellaArmeniaYerevanAustriaVienna31 more rows
Which city is the biggest capital of Europe?
BerlinLargest citiesRankCityCountry1BerlinGermany2MadridSpain3RomeItaly4ParisFrance8 more rows
Is Berlin bigger than London?
London realistically has a lot more than 8.6m people, and there are definitely bigger urban areas in Europe than Berlin, with a measly 3.6m.
Which country currency is high?
Kuwaiti DinarKuwaiti Dinar has been the highest currency in the world for a while now because of the oil-rich country’s economic stability….1. Kuwaiti Dinar (KWD)- Highest Currency Value in the World.Sr.No.1Highest Currency in the WorldKuwaiti DinarValue of1 KWDIn INR (in Dec 2020)241.43 INR9 more columns•Dec 2, 2020


Panerai launched three Luminor super clone watches-Luna Rossa Regatta (PAM01038), Luna Rossa Chrono Flyback (PAM01037) and Luna Rossa GMT (PAM01036).
These watches have the same monochromatic color scheme and have a unique “sandwich dial” made of the lower dial and luminous paint. The numbers on the dial are made of luminous paint. The top of the dial is covered with Luna Rossa canvas.
Swiss Panerai Replica Watches 47mm case on Carbotech, which is a proprietary carbon fiber reinforced polymer that makes it large but lightweight.
The countdown function is measured by two central hands controlled by a four o’clock button. Each time you press the button, the minutes will go back one minute until you reach the desired position.
The Chrono Flyback is 44 mm in diameter and features a sandblasted ceramic case and bezel. The Luxury Panerai Replica Watches dial is almost identical to the regatta except for the tachometer scale. It operates like a normal flyback chronograph; the button at 4 pm resets the chronograph hands to zero.
It is powered by automatic calibration. P.9100, this is a flyback chronograph movement without the above-mentioned countdown function. As the standard configuration of all Panerai movements, it is equipped with a double barrel, which can retain power for three days.
With the help of Ref.7300, Twenty~4 series products have been expanded and new models have been added. It is the first automatic movement in this series. Swiss Quality Patek Philippe Replica chose a very complicated case shape, calling it rounded corners and not making justice a reality. The diamond-encrusted bezel gives a rounded feel, while opening towards the top and bottom of the integrated bracelet.
Patek Philippe offers Ref. 7300 stainless steel or rose gold. The dial not only has a central seconds hand, but also a date window at six o’clock. They have bold Arabic numerals that match the hands, and are close to the sunburst dial, in gray, blue or brown. The rose gold model also offers a silver dial with linen texture.
The Replica Watch beautifully finished movement has an outstanding gold rotor made of 21k gold and is equipped with Gyromax balance and Spiromax balance springs for best accuracy. The movement can be admired through the sapphire case back of Nos. 20 to 4.
The 36 mm diameter watch is perfectly proportioned, even the rose gold version can be worn with casual or more formal outfits. Patek Philippe expanded the influence of the Twenty~4 series through innovative design to attract women who prefer a traditional appearance with a slightly mechanical movement without sacrificing its powerful DNA function.
The new circular model does not mean that the original 20 to 4 rectangles are gone and forgotten. Patek Philippe Twenty~4 Replica launched two new models this year, showing that the original design since 1999 is still very strong. Slightly bold hands, Arabic numerals and luminous hour markers replace the diamonds on the dial, adding a modern touch to this Twenty~4, making you forget that this model has celebrated its 20th anniversary.
The new Luminor Firenze Replica Watch was previously only found on Radiomir limited edition or complex models. It was the first time-limited Luminor with an engraved case. With a diameter of 47 mm, it is essentially an engraved version of the well-loved traditional Luminor PAM 372.
As before, the Panerai Replica case-including the trademark crown and bridge-is hand carved and then filled with black lacquer.
Iris or Florentine lilies appear repeatedly on the dial at six o’clock. The Perfect Panerai Replica dial is metallic dark gray with radial drawing. It has a sandwich structure, which means that the luminous hour markers are cut off on the dial, and Super-Luminova is coated on the disc below.
The Fake Panerai Watches P.3000/F movement is laser-engraved, the same pattern as on the case, but due to the technology it is engraved deeper and the edges are cleaner. Mechanically the same as the standard movement, it is manually wound and has a three-day power reserve.


Thompson Reuters, 4DD Software Tackle “TMI”
Sometimes we have no choice but to boil the ocean. Investigative professionals who are looking for a missing child or medical researchers trying to discover a cure for a disease, for example, need to know that they are taking in and synthesizing all relevant data to quickly arrive at actionable next steps.
Big data companies like Thomson Reuters not only help customers manage large volumes of information, but they also need to manage multiple ecosystems of their own data and allow key information on disparate systems to be able to come together to form meaningful patterns and create more complete pictures around critical activities. And, according to Thomson Reuters Chief Technology Officer James Powell, that can be difficult.
But not as difficult today as it was a year ago. Last year, Thomson Reuters developed a unique strategic relationship with 4DD Software, guiding and underwriting new product development on 4DD's flexible technology platform. Thomson Reuters provides financial support, plus executive expertise, bench strength and market presence, and 4DD brings agility and its breakthrough technology platform that is uniquely able to marry, manage and make sense of large, disparate data sets, and also allowing Thomson Reuters and its businesses to improve their technology processes and reduce loads on their servers.
4DD enables Thomson Reuters to create modifiable and reusable enterprise-ready apps that can infuse data with business logic and integrate it with other information. For example, a customer could provide data in a variety of information formats and integrate it with content from external networked sources, such as data in a Thomson Reuters product. The 4DD process can be programmed to compare data, translate from multiple languages, analyze and sort. And a process that is useful against one set of data can be quickly modified for similar use against other sets of data.
"The process is called waterfall searching," said Powell. "It's quick and format-agnostic, and doesn't require database administrators to operate." Thomson Reuters customers are already reaping the benefits of the company's relationship with 4DD. And behind the scenes, 4DD is helping Thomson Reuters manage its proprietary data sets so they can be more interactive with one another.
Thomson Reuters has many customers with massive amounts of data – think government agencies, banks, academic institutions and large law firms. 4DD can help institutions better understand their data and also can help make that data more powerful by comparing it to other data sets. For example, consider the data integration difficulties that often accompany bringing two institutions together. 4DD could translate digital records or documents from an acquired institution into the format of another.
"It's exciting to be working with Thomson Reuters," said Bennett McPhatter, CEO, 4DD Software. "They have exceptional technology and unrivaled data. This important strategic partnership validates how 4DD technology can be successfully applied against the largest and most complex big data environments and in service to Thomson Reuters customers."
"Our customers have more than enough data at their disposal," Powell said. "The issue is that relevant sets of data couldn't be combined or compared. With 4DD, we can ask each data set in its own language what we want from it, and we can move results down a pipeline, culling out the unnecessary and irrelevant. The flexible federated technology at the heart of 4DD solves a critical business problem for our customers and for us."


Samsung announced at the Unpacked event on Wednesday that the new smartphone series will use Galaxy AI, its own artificial intelligence system.
Samsung, a big company that makes phones and other electronics, has shown its new best product, the Samsung Galaxy S24. It has really smart features that use artificial intelligence.
The company announced new products on January 17, 2024, at a big event in San Jose, California, after showing them off at their Kings London office earlier in the week.
Information about what a product can do and how much it costs.
Samsung has a new phone called the Galaxy S24. It comes in different versions like the S24, S24 Plus, and the fancy S24 Ultra.
Samsung said that the S24 and S24+ phones use Qualcomm and Samsung’s own chips. At the same time, the S24 Ultra is the best model from the company, and it has strong features with Qualcomm’s latest Snapdragon Series 8 Gen 3 optimized for Galaxy.
Samsung made the screen bigger for the new Galaxy S24 phones. The regular S24 phone now has a larger 6. 2-inch screen, while the S24 Plus has a bigger 6. 7-inch The S24 Ultra is still big at 6. 8 inches, but its screen is flat instead of curved.
Furthermore, the S24 Ultra’s metal body is now made of titanium, which makes it a little thinner but not lighter than the older versions. The S24 and S24 Plus have a new look with less curved edges and more straight edges.
Samsung changed the S24 Ultra’s second zoom camera so it now has 5 times magnification instead of 10 times. But it can still achieve 10 times magnification using a special technique. The change is important for one of the main parts of the Galaxy Ultra lineup.
The company announced that the Galaxy S24 will cost $800 and the Galaxy S24 Plus will cost $1000. The Ultra version will be sold for $1300, which is $100 more than the last model.
You can order the phones before they are officially released, and they will start shipping on January 31, 2024.
Smartphones that use AI technology.
At the Unpacked event on Wednesday, Samsung said that the new smartphones use Galaxy AI, their artificial intelligence system.
“Galaxy AI was made using our history of being innovative and our knowledge of how people use their phones. ” “We can’t wait to see how people all over the world use Galaxy AI to make their lives better. It will open up new opportunities,” said TM Roh, a high-ranking Samsung executive.
The phones have Galaxy AI which includes different AI features like “Live Translate” for instant voice and text translations. This helps users write in the right way and understand foreign languages during phone calls.
The S24 series can be used to make phone calls between different languages and dialects, and it works for calls between cell phones and home phones. People can choose the language they want to use on their phone, and the phone remembers which languages were used in each call. The Galaxy S24 Ultra comes with an S Pen and can use AI to change handwritten notes into digital text and also correct any spelling or grammar mistakes.
Samsung said that the new smartphones have photo editing tools that use artificial intelligence to help improve pictures. People can move or change the position of things in their pictures and add borders to fix a tilted picture frame using the generative AI tool.
Also, the Galaxy’s AI gives users a way to improve their photos with automatic suggestions for editing.
Samsung promises that its phones will receive updates to the operating system for seven generations and security updates for seven years.


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The third-largest aviation market in the world is facing turmoil after its fourth-largest airline declared bankruptcy earlier this month.
Go Airlines -- operating under the Go First brand (earlier called Go Air) -- blamed faulty engines from US-based Pratt and Whitney, which grounded many of its aircraft.
The US firm has denied the allegations. But the bankruptcy came at a time when things were finally starting to look up for the industry.
Profitability finally seemed nigh for the sector, which hadn't made profits in over a decade, according to data from rating agency Crisil.
Debt levels for the industry have come down, largely driven by privatisation of Air India and the government taking over much of its loans.
Air India's losses also contributed to the airline industry's lack of profitability.
Debt for the industry is in excess of Rs 28,000 crore (Rs 280 billion), and is not expected to increase for some time.
This is also helped by the fact that recent orders for new aircraft are only expected to come in from 2025-2026.
Airlines have been doing more business than before.
Revenues went up from around Rs 55,000 crore (Rs 550 billion) in 2012-2013 to an estimated Rs 1.4 trillion by 2022-23, a compounded annual growth rate of 10.1 per cent.
Margins have improved based on the industry's standard measure of earnings before interest, tax, depreciation, amortisation and lease rentals (EBITDAR); aided by increasing passenger traffic and higher ticket prices.
The 12 per cent EBITDAR margin expected in 2022-2023 is higher than the pre-pandemic period.
Trouble in the sector, however, is not new and a number of airlines have gone bust in the past, including Kingfisher Airlines in 2012 and Jet Airways in 2019.
A number of new airlines have come up since, including Akasa Air and regional carrier IndiaOne Air, hoping to capitalise on a post-pandemic revival.
This is part of a broader global trend. More airlines were born than died over the last two years.
The inactivity of Go First may help other airlines in India's competitive market as it had a 7.8 per cent market share.
Passenger traffic is expected to continue to rise this year and the next. Projections for 2023-2024 suggest around 400,000 passengers would be flying every day.
Feature Presentation: Ashish Narsale/Rediff.com

domain: news


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New closed Facebook Group is created for those of Lyukum Cooking Lab followers who would like to be informed about coming and new events — classes, tasting parties, etc. In addition, I am going to share everything I have to say about food and cooking on the go. Most of postings will be bilingual (English + Russian). News and announcements for local clients will be in English only. You do not need to be my Facebook friend to join the group, but you have to send me a personal message with request via Facebook. See you there!
There are two new cooking classes coming, on August 27 (10:30am) and on October 1, 3pm: Smoking Hot! Join these classes via Thumbtack or Facebook group.
$55 per person
Do you like smoky flavor? Do you know that it takes no longer than 15 minutes to make most of hot smoked dishes with stovetop smoker? If you own Cameron’s stovetop smoker or think about adding it to you kitchen cookware collection, join this class! I own Camerons for more than 10 years and I use it for smoking meat, poultry, dairy, fruit, vegetables, grains — almost anything. I’ll share my experience, tips and tricks I learned over years, will show you how quick and easy it is to use this smoker.
we will make and eat (non-vegetarian):
1. Stuffed and smoked chicken breasts (gluten-free)
2. French omelette with smoked scallops (gluten-free)
3. Smoked burgers (gluten) OR riblets (gluten-free)
we will make and eat (vegetarian and gluten-free):
1. appetizers with smoked plumcots, brie, and thyme
2. shakshuka (poached eggs) with smoked tomatoes
3. smoked hominy grits with sauté vegetables

domain: food


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Your Search Returned 120 tagged news reports
Although skulls are common to all vertebrates, they vary from species to species, and even among individuals of the same taxonomic group. Knowing what to look for-both the similarities and the differences-can provide a fascinating perspective on how
Immigrants from across the state and their supporters from the California Immigrant Policy Center gather at the Capitol today to lobby for bills that would expand health care to undocumented immigrants and lower the cost of phone calls at local jails.
Saturday, May 10, 2014 ABC7 takes you inside the California Academy of Sciences as they build one of the most extraordinary exhibits in the world. More than 650 skulls, ranging from an enormous African Bull Elephant to tiny birds and tall giraffes,
UC Merced officials are scheduled to dedicate the schools nature reserve today, with the goal of preserving vernal pools and the animal species who reside there for generations to come. UC Merced Chancellor Dorothy Leland, faculty and students will
Smith inherited a Carmel Valley cottage filled with treasures...The treasures consist of oil paintings and watercolors by their parents, Fred Pomeroy and Mary Barnas Pomeroy. Now the sisters have a problem what to do with all the paintings. They have
Though the Senate and Assembly usually meet on Thursdays, there are no floor sessions today. Monday is off for President's Day, so in order to get their per diem allowances, which require legislators to gather at least every three days , they will
Every NightLife showcases a different theme and schedules different activities for its guests, but the best part is that while regular day tickets to the Academy are priced at $29.95 ($24.95 for students), NightLife tickets will only set you back $12.
They will do further studies on it and it is a big asset to them. According to the Monterey Bay Aquarium's Web site, that species of sand dollars usually live six to 10 years and their average size is 3 inches across. The critters live in low
The Associated Press An experiment to see if killing invasive barred owls will help the threatened northern spotted owl reverse its decline toward extinction is under way in the forests of Northern California...Fish and Wildlife Service said Friday
Nov. 27, 2013 Resident of Los Gatos Sheldon "Shel" Magill Smith of Los Gatos, California died peacefully in his sleep on November 27th, 2013, at the age of 82...Paul Minnesota and moved to California in his early teens before the outbreak of World

domain: biology


Apple has convinced hardware maker Toshiba to open another plant in China dedicated to making LCD panels for Apple's devices.
Toshiba has announced plans to set-up a manufacturing unit in the Ishikawa prefecture in China with a total investment of 100 billion yen ($1.19 billion), Reuters reports.
Apple will also invest in the construction of the plant, the Nikkei said.
The work on the plant, which will be dedicated to making low-temperature polysilicon LCD panels that allow high-resolution images, will begin next year with production will predicted to start in the second half of 2011.
Toshiba Mobile Display already has a manufacturing plant in the area which produces 8.55 million units of LCD displays. Experts believe that this number will more than double once the new plant becomes operational.
Apple uses LCD displays on its iPhone, iPod Touch and iPad devices, as well as its range of Mac computers, and has a reputation for switching suppliers if is getting a better deal.


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Is it too late or too early to talk about how much I love this Christmas movie? Jingle Jangle: A Christmas Journey is a wonderful and magical story the entire family can enjoy. In this video, I share what I loved about the movie. Note, there are no spoilers in this video. I stick to what you would see in the trailer.
From the wardrobe, to the music, to the talent, I was so impressed by this movie. I will admit that I might be a little biased. I love everything Phylicia Rashad is in and want to be like her when I grow up. Also, I was a theater kid, so these types of productions brings me a lot of joy.
The underlying message within the movie was the most beautiful part. It’s one thing to talk about how important it is to believe in yourself. It is a whole other thing to illustrate how self-doubt results in losing your glow and believing in yourself results in regaining your glow.
What did you think of the movie? Share with me in the comments.
Also, remember to connect with me. I love hearing from you.

domain: artistic


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A place for Staffordshire bull terrrier owners, breeders, trainers, admirers, ect. to come and socialize. We are a family friendly site, so everyone is welcomed to come and learn as well as just have fun!
Rumors spread that the mighty Arceus would never again awake to save the world from all of its misery. . . Until now.
Free forum : The Terra Region is Heavily forest with dense fields and rolling plains it is a paradise that nevertheless poses a challenge for most trainers.
Where the best trainers come.
A Pokemon Trainer's website for finding more trainer friends Try our Trainer Directory for google plus and twitter that is updated daily! New poketubers forum! New host your battles here forums!
Join Pokémon Pikachu Forums and welcome our trainers. Battle trainers from all over the world! Create your own Pokémon RPG, Pokémon Trainer and MORE! We've got news of Black & White Versions! Come in and become a Pokémon Master today!
Free forum : Your dreams of becoming a pokemon master are finally coming true! Capture your dream pokemon, battle leaders and defeat the elite four!
Welcome to Trainer Turf! Here, one can battle some of the best of the best, or enjoy stories of the past of a trainer here, or really anything, so long as it's about Trainers!
Pokemon Revolution based on Pokemon. You can create your trainers, battle with other trainers and catch pokemons. There is also a lot more stuff you can do.
A place for trainers - Pokemon Nation
A place for trainers - Pokemon Empire
A guild for all players! Come here to cheat, meet new friends, release your work, and more! Join today!
Free forum : Pokeblock is a forum where you can role play as a wild pokemon! You may also role play as a trainer, a breeder, or a scientist! We also allow role playing of trainers' pokemon!
A friendly Pokemon Fan-site. We do our part to enrich the minds of trainers who wish to be the very best, whether it be the best at Competitive Pokemon, Role-playing or both.
A brand new region for trainers and pokemon, this world is full of fun, challenges, but also evil.
A Region where Pokemon Trainers can battle to their full Power
This is a forum where pokemon trainers around the world gather. We do wi-fi battles, trades. we also have our own auction and clan. we introduce you to a gym leader and elite4 system.
Welcome to Trainers of Pallet, where new trainers and Elites meet to discuss, gab and chat everything Pokemon! We are a new community for all ages looking for new Pokemon Trainers who are dedicated, active and like to have fun, meet new friends and h
The forums for Club Penguin Cheat Central. We have trainers, cheats, news updates, SWF's, trackers, and MORE!
One of the world's best and only Academy for trainers and their Pokemon. Want to be a Trainer, Breeder, Coordinator, poke Professor even a Poke Nurse or Doctor? Then thus is the place for you!
Free forum : Come here and discuss all things game related! Pokemon trainers become Gym leaders and Brawlers become Champions!
Barkingmad. Forum for all dog lovers, breeders, trainers, and those who just generally love to talk about dogs. If that's you, then this is the place for you!
Free forum : Welcome to Lawicke, an elite boarding academy for young Pokémon trainers.
This forum is all about getting all the great trainers around the world into one place where everyone could let out the stories of their adventure.
Free forum : Register Now and Join the Chatbox to Battle trainers, gym leaders and elites. Have Fun
Professional Games Cheating

domain: entertainment


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COVID-19 Information Guide
3 Months after Pandemic stage
Did this coronavirus spread from animals to humans?
Although not common, coronaviruses can be transmitted from animals to humans. Bats can be reservoir hosts for viruses which can cross species barriers to infect humans and other domestic and wild mammals.
In the last two major coronaviruses that were transmitted to humans, transmission occurred through intermediate hosts: the masked palm civet (SARS) and dromedary camels (MERS).
The 2019 Novel Coronavirus (2019-nCOV), now known officially as COVID-19 or Corona Virus Disease, is thought to have originated in bats and transmitted to humans through an intermediate animal host. Investigations are still ongoing.
Is my pet at risk from the COVID-19 coronavirus, or will my pet infect me?
According to the World Health Organization, there is no evidence to suggest that dogs or cats have become ill with this virus or will become a source of infection of COVID-19 in other animals or humans.
In late February 2020, Hong Kong authorities quarantined a dog after samples from the dog’s nasal cavity and mouth tested “weak positive” for the virus. The dog’s owner had tested positive for COVID-19. The dog did not show signs of illness. Authorities believe it is a case of human to animal transmission but stress that it is not cause for alarm.
It’s important to remember that viruses can sometimes infect a species but not cause illness in that species, nor become transmissible to others. Again, it is not believed that pets such as cats or dogs can pass COVID-19 to humans.
And, as far as realistic risk factors—if, for instance, your dog is usually at home and doesn’t contact other dogs or people and no one in your household has COVID-19, the odds that your pet would become infected are highly unlikely.
If you have COVID-19, you should restrict your contact with pets and other animals, just like you would with other people. When possible, have another member of your household care for your animals while you are sick. Avoid direct contact with pets, including petting, snuggling, being kissed or licked, and sharing food. If you must care for your pet or be around animals while you are sick, wash your hands before and after you interact with pets and wear a facemask as directed by your physician.
As a matter of everyday health, it is always a good idea to wash your hands with soap and water after contact with pets to help avoid transmission of more common illness-causing agents, such as E. coli and Salmonella.
What should I do if I think I am sick but my pet needs veterinary care?
If you contract this illness or have symptoms consistent with this infection and your pet needs veterinary care, please CALL your veterinary clinic or emergency veterinary hospital first. They may be able to accommodate your situation by coming out to your car to transport your pet into the clinic for an examination and communicate with you via phone regarding the diagnosis and treatment plan. They may also have other options for you, such as telemedicine, so that your pet can receive needed care during this time.
To protect your pet from respiratory diseases, vaccinate your pet for Bordetella, parainfluenza and canine influenza, which are the most common vaccine-preventable respiratory diseases in pets.
Your veterinarian can help you determine which vaccines your pet should have, based on its risk factors.
Is there a vaccination against the COVID-19 coronavirus that my pet can receive?
Currently, there are no COVID-19 vaccines available for humans or animals. The World Health Organization estimates that a vaccine for humans could be available in 12-18 months.

domain: medical


text: This is a subgenre of folk music that emerged in the 1960s and 1970s. It is characterized by its focus on personal storytelling, acoustic instruments, and socially conscious lyrics. Contemporary folk often draws on traditional folk music, but also incorporates elements of rock, country, and other genres. Slip.stream presents you with exclusive Contemporary Folk tracks collection that creators can use without worry on all content platforms. Check them out.


Have you encountered the Microsoft Visual Basic error “Runtime error ’91’: Object variable or With block variable not set” when you open a SOLIDWORKS file? Or when you create a new SOLIDWORKS macro and see that message appear when you run it?
Fortunately for you, this is a very common VB error, and it’s not very difficult to determine where the problem lies.
What causes runtime errors 91?
The reason why the pop-up window with the message “Runtime Error 91: Object variable or with block variable not set” appears is because the DCOMCnfg.exe file may be corrupted. The DCOMCnfg.exe file is commonly used to configure permissions and set security settings on a system. If there is a problem with this file, your system will not be able to load the files needed to start up, and a runtime error 91 will be displayed.


The Charter School
The Charter School has been transformed from its original 1950s buildings into an exemplary modern learning environment for 1,200 pupils including a sixth form. The phased programme began with the creation of a new entrance foyer, formed by opening up an existing block and roofing over a courtyard.
Designed to be the dynamic heart of the school, this space features a sculptural, tree-like structure that supports its partially glazed roof. The roof was designed to harvest both solar energy and rainwater – a manifestation of the school’s commitment to a sustainable future. From the entrance foyer, newly glazed routes lead to the school hall, dining block, library, sports hall and teaching spaces.
As part of a strategy to minimise energy and conserve resources, the main four-storey teaching block was stripped back to its frame and rebuilt with new multicoloured cladding to enliven the façade. Night-time ventilation combined with thermal mass helps stabilise internal temperatures. CO2 sensors linked to external air vents and the use of finishes with very low toxicity ensure good air quality in teaching spaces. Extensive green roofs improve the biodiversity of the site and exploit natural cooling techniques. The partially glazed new roof over an existing courtyard is used as a collector of solar energy and rainwater for recycling.


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Transylvania has partnered with nearby Bluegrass Distillers, ordering more than 400 gallons of hand sanitizer along with 60 touchless dispensers.
Transylvania University has named Johnnie Johnson as its vice president for admissions effective immediately. Johnson has served as the interim vice president for enrollment since July 2019.
Sarah Coen, a national expert on enrollment and student success, has been named as Transylvania’s new vice president for strategic initiatives and enrollment management.
If you’re looking to learn more about today’s Juneteenth celebration, which commemorates the end of slavery in the U.S., the Transylvania library has compiled a list of resources — from websites to books for adults and children.
Over the next couple of months, Transylvania will be putting the finishing touches on its new W.T. Young Campus Center — which will be ready for students when they return this fall.
Transylvania is participating in a pen pal program that will bring together LGBTQ college students throughout the state — at a time when many of them may feel isolated because of the pandemic.
Healthy at Transy is a flexible framework that will allow us to return to in‑person instruction and on-campus housing along with full academic support services this August.
Fall registration for current students will occur June 22‑24 and for incoming first‑year students on June 26 and 29.
As representatives of the Transylvania University alumni base, we join together to condemn, in the strongest possible terms, racism, violence against the Black community and the systemic injustices that plague our nation.
It is time to listen, learn and then act to bring about racial understanding and justice.


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Heliotrope is a nice speculative magazine. I printed Issue 5 and read it the other night; I was impressed with the finished product. #5 is a Michael Moorcock retrospective. It includes a couple of interesting stories and a number of fine articles that have effectively elevated my interest in reading Moorcock's fiction.
That's right, I haven't looked at anything this esteemed author has written. I'm pretty late to the fantasy genre, folks. Well, actually I read a lot of fantasy in my youth--C.S. Lewis and Tolkien, of course, but also Dahl and Bradbury and a host of others whose names escape me.
But then I got onto the science fiction and horror train and, with brief forays into mystery and suspense, that's where I've stayed.
There are some great fantasists out there, and I'm really intrigued in looking at some of these Moorcock titles. I think one of the things we all do as we age and mature is search for outlets that will help us, even in small ways, recover that sense of child-like awe that seems to dissipate a little more each year.
Yeah, getting older stinks from that perspective. Remember those languorous summer days of your youth, when the world was bright and fresh and a single day stretched on forever?
I think that's what fantasy can do, in some cases. It can take you back there.
Now, of course these genres all overlap, and much of the sci-fi and horror I read has fantastic elements. But I haven't read sword and sorcery since Tolkien, and even that was pretty light on it.
Neil Gaiman's story in Heliotrope #5 is good; it kind of grows on you. It's about resisting that urge to charge into adult life; it's as if Gaiman is warning us--Don't do it! Stay with Elric, stay in the ruined temple! Adult life is filed with sadness and awkward moments!
Indeed, the story is peppered with awkward moments--sexual tension and bullying, to name just two. But for our protagonist, Richard, those things are mediated and mitigated by his strong appreciation for the fantastic.
It's a good tale and, as I said, many of the articles are strong. Heliotrope is closed to submissions, but they pay well and produce a nice product. Print that magazine and tip them a buck or two if you like what you see...
On an unrelated note, what happened to me? I'm starting to enjoy country music, and so is our little girl. When she cries, we put on some Kenny Chesney and she quiets down. I've already documented her love of Conway Twitty...Sheesh.


This event is 21 and over.
$25.00 – General Admission
*plus applicable service fees
Tickets available at The Independent box office (628 Divisadero, SF) with no service charge.
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Milly is a rock band from Los Angeles fronted by songwriter and multi-instrumentalist Brendan Dyer. Their sound melds together elements of classic shoegaze, slowcore, and lo-fi indie rock, coalescing into an intense, singular musical impression. Milly began as Dyer’s home recording project in his hometown of Bristol, Connecticut before finally taking its current formation as a live band in Los Angeles.


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Ivory, paper, paint, metal, mother of pearl
closed: 10 1/2 x 7/8 x 1 1/4 in. ( 26.7 x 2.2 x 3.2 cm )
Fan with shaped ivory guards and sticks with gold and silver painted openwork decoration, and paper leaf with color-printed scenes with hand-painted highlights on obverse and reverse; obverse with multiple figures, including adults and children, in desert landscape, with decorative framing motif stamped in gold on either side; reverse with large group of allegorical female figures representing arts and sciences, with two cupids with cornucopias within the group; metal rivet with mother of pearl buttons.
According to the accession records, this fan was purchased in Seville, Spain, around 1902.
Gift of Mrs. Roswell Skeel, Jr.
Due to ongoing research, information about this object is subject to change.

domain: design


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[show abstract][hide abstract] ABSTRACT: Cardiovascular disease poses a major challenge for the 21st century, exacerbated by the pandemics of obesity, metabolic syndrome and type 2 diabetes. While best standards of care, including high-dose statins, can ameliorate the risk of vascular complications, patients remain at high risk of cardiovascular events. The Residual Risk Reduction Initiative (R3i) has previously highlighted atherogenic dyslipidaemia, defined as the imbalance between proatherogenic triglyceride-rich apolipoprotein B-containing-lipoproteins and antiatherogenic apolipoprotein A-I-lipoproteins (as in high-density lipoprotein, HDL), as an important modifiable contributor to lipid-related residual cardiovascular risk, especially in insulin-resistant conditions. As part of its mission to improve awareness and clinical management of atherogenic dyslipidaemia, the R3i has identified three key priorities for action: i) to improve recognition of atherogenic dyslipidaemia in patients at high cardiometabolic risk with or without diabetes; ii) to improve implementation and adherence to guideline-based therapies; and iii) to improve therapeutic strategies for managing atherogenic dyslipidaemia. The R3i believes that monitoring of non-HDL cholesterol provides a simple, practical tool for treatment decisions regarding the management of lipid-related residual cardiovascular risk. Addition of a fibrate, niacin (North and South America), omega-3 fatty acids or ezetimibe are all options for combination with a statin to further reduce non-HDL cholesterol, although lacking in hard evidence for cardiovascular outcome benefits. Several emerging treatments may offer promise. These include the next generation peroxisome proliferator-activated receptoralpha agonists, cholesteryl ester transfer protein inhibitors and monoclonal antibody therapy targeting proprotein convertase subtilisin/kexin type 9. However, long-term outcomes and safety data are clearly needed. In conclusion, the R3i believes that ongoing trials with these novel treatments may help to define the optimal management of atherogenic dyslipidaemia to reduce the clinical and socioeconomic burden of residual cardiovascular risk.
[show abstract][hide abstract] ABSTRACT: A comparative study of the electrochemical conversion and the biotransformation performed by the cytochrome P450 (CYP450) obtained by rat liver microsomes has been achieved to elucidate the oxidation mechanism of both acebutolol and alprenolol. For this purpose, a wide range of reactions such as N-dealkylation, O-dealkoxylation, aromatic hydroxylation, benzyl hydroxylation, alkyl hydroxylation, and aromatic hydroxylation have been examined in this study, and their mechanisms have been compared. Most of the results of the electrochemical oxidation have been found to be in accordance with those obtained by incubating acebutolol and alprenolol in the presence of CYP450, i.e., N-dealkylation, benzyl hydroxylation, and O-dealkoxylation reactions catalyzed by liver microsomes were found to be predicted by the electrochemical oxidation. The difficulty for the electrochemical process to mimic both aromatic and alkyl hydroxylation reactions has also been discussed, and the hypothesis for the absence of aromatic hydroxylated and alkyl hydroxylated products, respectively, for alprenolol and acebutolol, under the anodic oxidation has been supported by theoretical calculation. The present study highlights the potential and limitation of coupling of electrochemistry-liquid chromatography-high-resolution mass spectrometry for the study of phase I and phase II reactions of acebutolol and alprenolol.
Analytical and Bioanalytical Chemistry 05/2013; · 3.66 Impact Factor
[show abstract][hide abstract] ABSTRACT: In situ NMR spectroelectrochemistry is presented in this study as a useful hybrid technique for the chemical structure elucidation of unstable intermediate species. An experimental setting was designed to follow the reaction in real time during the experimental electrochemical process. The analysis of (1)H NMR spectra recorded in situ permitted us (1) to elucidate the reaction pathway of the electrochemical oxidation of phenacetin and (2) to reveal the quinone imine as a reactive intermediate species without using any trapping reaction. Phenacetin has been considered as hepatotoxic at high therapeutic amounts, which is why it was chosen as a model to prove the applicability of the analytical method. The use of 1D and 2D NMR experiments led to the elucidation of the major species produced from the oxidation process. We demonstrated that in situ NMR spectroelectrochemistry constitutes a fast way for monitoring unstable quinone imines and elucidating their chemical structures.
Analytical and Bioanalytical Chemistry 05/2013; · 3.66 Impact Factor
[show abstract][hide abstract] ABSTRACT: Familial hypercholesterolemia (FH) is a frequent monogenetic disease (1/500 for heterozygous and 1/1,000,000 for homozygous). The FH patients are exposed to a dramatic increase of vascular risk of about 50% for men and 30% for women compared to the general population. The diagnosis can be suspected in case of high plasma concentration of LDL-C over 2.20mg/dL, first relatives with FH in the family, xantomas and early cardiovascular events. The "Simon Broone criteria" or the Deutch scale are useful tools to ascertain the diagnosis but DNA testing is the gold standard. The mutations are mainly located on the LDL receptor gene and less frequently on Apo B100 or PCSK9 genes. The "cascade" testing of the family from the index patient is a critical step to detect new cases and start early treatment. Long-term treatment with statins has dramatically decreased the vascular risk to the level of the general population. In primary prevention, LDL-C should be less than 130mg/dL and in secondary prevention less than 100mg/dL (as a best<70mg/dL). It is often difficult to reach these goals and combined treatments with ezetimibe or other drugs can be used. When the goals are not reached with the maximum tolerated drug treatment, a decrease of 50% of LDL-C can be acceptable but the patients should be referred to lipid clinics. A yearly vascular survey of the FH patients is recommended, especially in adults or when the treatment goal is not reached. Homozygous FH patients must be referred to a specialized center.
[show abstract][hide abstract] ABSTRACT: The EVOLUTIV survey was carried out through Internet among 135 general practitioners (GPs) and 135 specialists (endocrinologists/diabetologists: 82.8%) used to treat type 2 diabetic (T2D) patients. Using the methodology of clinical vignettes they were proposed five T2D patient's profiles – each with two different clinical case redactions – combining clinical practice situations (oral bitherapy, recently diagnosed or long standing diabetes, insufficient glucose control or uncontrolled diabetes, absence of or existing microvascular or cardiovascular complications). Each physician had to determine the antidiabetic treatment for each of these 10 clinical cases in which two key parameters, HbA1c and BMI, varied in turn. For each clinical case they had to answer four questions on glucose control (HbA1c) objective, weight loss objective, recommended therapeutic strategy and main decision criteria supporting their therapeutic choice. A total of 2570 clinical cases were collected and analyzed.
Main results were:
–Glycemic and weight loss objectives were globally ambitious; however chosen therapeutic strategies, particularly by GPs, were not always adapted to these objectives;–A different attitude of GPs and specialists with regard to therapeutic intensification. GPs preferentially chose maintenance of oral strategies and underutilized injectable strategies (GLP-1 analogs and insulin), these latter more largely and more precociously preconized by specialists, particularly in case of HbA1c ≥8% and/or BMI ≥29 kg/m2. Use of the DPP-4 inhibitors class as add-on to metformin was predominant for GPs as for specialists with as a consequence a delayed introduction of GLP-1 analogs, particularly for GPs (except for BMI 35 kg/m2);–HbA1c was the major decision criteria; however at early diabetes stages treatments/drugs preconized by GPs were generally not adapted to a strict glycemic control objective. At more complex stages (long standing diabetes uncontrolled and/or with complications), referral to specialist increased considerably, mainly for the highest HbA1c levels (≥9%) and was more marked with increasing BMI (≥29 kg/m2).
Médecine des Maladies Métaboliques 02/2013; 7(1):58–78.
[show abstract][hide abstract] ABSTRACT: The coupling between an electrochemical cell (EC) and a mass spectrometer (MS) is a useful screening tool (EC-MS) to study the oxidative transformation pathways of various electroactive species. For that purpose, we showed that the EC-MS method, carried out in the presence and absence of isotope (18)O labeled water leads not only to a fast identification of oxidation products but also leads to a fast elucidation of the mechanism pathway reaction. We examined herein the case of the electrochemical hydrolysis of activated aromatic ether. Acebutolol (β-blockers) was selected herein as model of activated aromatic ether, and its electrochemical oxidation was examined in both the presence and absence of isotope (18)O labeled water. To elucidate electrochemical hydrolysis pathway reaction: O-dealkylation or O-dealkoxylation, our approach was used to prove its applicability. The electrochemical oxidation mechanism was then elucidated showing an O-dealkoxylation reaction. In addition, density functional theory (DFT) calculations fully support the experimental conclusions.
[show abstract][hide abstract] ABSTRACT: BACKGROUND: PCSK9 (Proprotein Convertase Subtilisin Kexin type 9) is a circulating protein that promotes hypercholesterolemia by decreasing hepatic LDL receptor protein. Under non interventional conditions, its expression is driven by sterol response element binding protein 2 (SREBP2) and follows a diurnal rhythm synchronous with cholesterol synthesis. Plasma PCSK9 is associated to LDL-C and to a lesser extent plasma triglycerides and insulin resistance. We aimed to verify the effect on plasma PCSK9 concentrations of dietary interventions that affect these parameters. METHODS: We performed nutritional interventions in young healthy male volunteers and offspring of type 2 diabetic (OffT2D) patients that are more prone to develop insulin resistance, including: i) acute post-prandial hyperlipidemic challenge (n=10), ii) 4 days of high-fat (HF) or high-fat/high-protein (HFHP) (n=10), iii) 7 (HFruc1, n=16) or 6 (HFruc2, n=9) days of hypercaloric high-fructose diets. An acute oral fat load was also performed in two patients bearing the R104C-V114A loss-of-function (LOF) PCSK9 mutation. Plasma PCSK9 concentrations were measured by ELISA. For the HFruc1 study, intrahepatocellular (IHCL) and intramyocellular lipids were measured by 1H magnetic resonance spectroscopy. Hepatic and whole-body insulin sensitivity was assessed with a two-step hyperinsulinemic-euglycemic clamp (0.3 and 1.0 mU.kg-1.min-1). FINDINGS: HF and HFHP short-term diets, as well as an acute hyperlipidemic oral load, did not significantly change PCSK9 concentrations. In addition, post-prandial plasma triglyceride excursion was not altered in two carriers of PCSK9 LOF mutation compared with non carriers. In contrast, hypercaloric 7-day HFruc1 diet increased plasma PCSK9 concentrations by 28% (p=0.05) in healthy volunteers and by 34% (p=0.001) in OffT2D patients. In another independent study, 6-day HFruc2 diet increased plasma PCSK9 levels by 93% (p<0.0001) in young healthy male volunteers. Spearman's correlations revealed that plasma PCSK9 concentrations upon 7-day HFruc1 diet were positively associated with plasma triglycerides (r=0.54, p=0.01) and IHCL (r=0.56, p=0.001), and inversely correlated with hepatic (r=0.54, p=0.014) and whole-body (r=-0.59, p= 0.0065) insulin sensitivity. CONCLUSIONS: Plasma PCSK9 concentrations vary minimally in response to a short term high-fat diet and they are not accompanied with changes in cholesterolemia upon high-fructose diet. Short-term high-fructose intake increased plasma PCSK9 levels, independent on cholesterol synthesis, suggesting a regulation independent of SREBP-2. Upon this diet, PCSK9 is associated with insulin resistance, hepatic steatosis and plasma triglycerides.
[show abstract][hide abstract] ABSTRACT: The aim of this study was to investigate macrophage reverse cholesterol transport (RCT) in hamster, a CETP-expressing species, fed omega 3 fatty acids (ω3PUFA) supplemented high fat diet (HFD). Three groups of hamsters (n = 6/group) were studied for 20 weeks: 1) control diet: Control, 2) HFD group: HF and 3) HFD group supplemented with ω3PUFA (EPA and DHA): HFω3. In vivo macrophage-to-feces RCT was assessed after an intraperitoneal injection of (3)H-cholesterol-labelled hamster primary macrophages. Compared to Control, HF presented significant (p<0.05) increase in body weight, plasma TG (p<0.01) and cholesterol (p<0.001) with an increase in VLDL TG and in VLDL and LDL cholesterol (p<0.001). Compared to HF, HFω3 presented significant decrease in body weight. HFω3 showed less plasma TG (p<0.001) and cholesterol (p<0.001) related to a decrease in VLDL TG and HDL cholesterol respectively and higher LCAT activity (p<0.05) compared to HF. HFω3 showed a higher fecal bile acid excretion (p<0.05) compared to Control and HF groups and higher fecal cholesterol excretion (p<0.05) compared to HF. This increase was related to higher gene expression of ABCG5, ABCA1 and SR-B1 in HFω3 compared to Control and HF groups (<0.05) and in ABCG1 and CYP7A1 compared to HF group (p<0.05). A higher plasma efflux capacity was also measured in HFω3 using (3)H- cholesterol labeled Fu5AH cells. In conclusion, EPA and DHA supplementation improved macrophage to feces reverse cholesterol transport in hamster fed HFD. This change was related to the higher cholesterol and fecal bile acids excretion and to the activation of major genes involved in RCT.
PLoS ONE 01/2013; 8(4):e61109. · 3.73 Impact Factor
[show abstract][hide abstract] ABSTRACT: Lipoproteins exchange of cholesterol esters and triglycerides through CETP (cholesteryl ester transfer protein), a transfer protein. It allows the exchange of cholesterol esters between HDL and LDL or VLDL triglycerides give back to HDL. In humans, this activity would allow more than 70 % of cholesterol esters present in the HDL to be transferred to LDL. The return of cholesterol to the liver via the LDL is very effective if they are properly metabolized. Otherwise, it is a particularly atherogenic metabolic pathway since the load LDL cholesterol esters which will accumulate in the circulation and be picked up by macrophages to promote lipid deposits. A number of preclinical and clinical data suggest that CETP would facilitate atherosclerosis in humans. By blocking its action, cholesterol esters remain on HDL to be eliminated by the liver. Genetic studies with loss of function mutations support this hypothesis, but the data are contradictory. In addition, it is unclear whether changes in the composition of lipoproteins obtained and especially HDL allow them to keep all their functions. Four molecules have been developed to block the activity of CETP with a consequent significant increase in HDL cholesterol of 30 to 130% depending on the degree of inhibition but also a reduction in LDL cholesterol up to 25%. Development of torcetrapib a potent inhibitor was discontinued due to adverse vascular effects primarily related to a specific action of this molecule on the renin-angiotensin system. Dalcetrapib which inhibited about 30% of the activity of the molecule has been interrupted for inefficiency. Two other potent inhibitors (anacetrapib and evacetrapib) are being developed and the first results of the cardiovascular intervention trials are expected in 2016.
Médecine des Maladies Métaboliques 01/2013; 7(6):575–579.
[show abstract][hide abstract] ABSTRACT: The Saxagliptin assessment of vascular outcomes recorded in patients with diabetes mellitus-thrombolysis in myocardial infarction (SAVOR-TIMI 53) trial was designed to test the effect of saxagliptin, a DPP-4 inhibitor, on the prevention of the occurrence of cardiovascular events in patients with type 2 diabetes (T2D). It is a 5-year, randomized, double-blind trial, conducted against placebo in 27 countries on 16,496 T2D patients. They received either a placebo or the saxagliptin 5 mg, or 2,5 mg in patients with renal failure (creatinine clearance <50 ml/minute). The treatment was given in addition to the usual treatment but gliptins or GLP-1 analogues were excluded. Patients were in secondary (80%) or primary cardiovascular prevention but with an additional risk factor (20%). The primary endpoint was a combined endpoint of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke. The trial was built to test a hypothesis from a non-inferiority to suggest the cardiovascular safety of the saxagliptin but also an assumption of superiority in cardiovascular prevention with a goal to reduce the relative risk of major cardiovascular events (primary endpoint) by 17%. The number of patients enrolled allowed testing these hypotheses with a good statistical power when 1040 events were observed. Patients were included in 27 countries with a large majority in North America and Western Europe. At inclusion the average age was 65.0 years with predominantly male (67%) patients. The average duration of diabetes was 11.9 years and mean HbA1c at baseline was 8.0+1.4%. Almost 12% of patients had retinopathy, 18% nephropathy and 2.5% amputation. Only 5% had no diabetes treatment and ~41% received insulin ± oral antidiabetics. The vast majority of patients (80%) received treatment with statins, antihypertensive and antiplatelet agents. Patients with cardiovascular history had more microvascular complications and were more often treated with insulin. The overall incidence of the primary endpoint was 2%/year. Investigators were asked to minimize the drop out of the patients less than 2,8%/year. The results of this study are expected in September 2013.
Médecine des Maladies Métaboliques 01/2013; 7(4):354–359.
[show abstract][hide abstract] ABSTRACT: OBJECTIVE: Assess the cardiovascular safety of Thiazolidinediones (TZD) in routine clinical practice. BACKGROUND: TZD are insulin-sensitizing antidiabetic drugs commonly used in type 2 diabetes, but their cardiovascular safety has been questioned. We examined the association between TZD use and major cardiovascular outcomes. METHODS: We examined 2-year mortality, non-fatal myocardial infarction (MI), and congestive heart failure (CHF) rates among outpatients with high cardiovascular risk and diabetes according to TZD use in the REACH Registry. Multivariable adjustment and propensity scores were used in the analyses. RESULTS: A total of 4997 out of 28,332 patients took TZDs at baseline. During follow-up, 1532 patients died. The mortality rates (95% confidence interval [CI]) were 6.5% (5.5-7.6) with TZD and 7.2% (6.33-8.06) without; adjusted hazard ratio (HR) was 1.06 (0.89-1.26, P=0.54). The lack of association with mortality was consistent across subgroups regardless of history of atherothrombosis or CHF. Rates of non-fatal MI (HR 1.10, 95% CI 0.83-1.45, P=0.50) and non-fatal CHF (HR 0.90, CI 0.75-1.09, P=0.27) were similar in users and non-users. TZD use was associated with an increased risk of CHF in patients aged >80years (HR 1.59, CI 1.06-2.40, P=0.03). CONCLUSIONS: Use of TZD was not associated with increased incidence of major cardiovascular events in patients with diabetes from this large registry. Older patients experienced an increased risk of CHF over the study interval. Limitations of this study include its observational design, and thus unmeasured confounders cannot be excluded.
International journal of cardiology 05/2012; · 7.08 Impact Factor
[show abstract][hide abstract] ABSTRACT: Anderson disease is a rare inherited lipid malabsorption syndrome associated with hypocholesterolemia and linked to SAR1B mutations. The aim of this article was to analyze the mechanisms responsible for the low plasma apolipoprotein Apo-B100 and Apo-AI in 2 patients with Anderson disease.
A primed constant infusion of (13)C-leucine was administered for 14 hours to determine the kinetics of lipoproteins. In the 2 patients, total cholesterol (77 and 85 mg/dL versus 155±32 mg/dL), triglycerides (36 and 59 versus 82±24 mg/dL), Apo-B100 (48 and 43 versus 71±5 mg/dL), and Apo-AI (47 and 62 versus 130±7 mg/dL) were lower compared with 6 healthy individuals. Very-low-density lipoprotein-B100 production rate of the patients was lower (4.08 and 5.52 mg/kg/day versus 12.96±2.88 mg/kg/day) as was the fractional catabolic rate (5.04 and 4.32 day(-1) versus 12.24±3.84 day(-1)). No difference was observed in intermediate-density lipoprotein-B100 and LDL-B100 kinetic data. The production rate of high-density lipoprotein Apo-AI was lower in the patients (7.92 and 8.64 versus 11.96±1.92 mg/kg/day) and the fractional catabolic rate was higher (0.38 and 0.29 versus 0.22±0.01 day(-1)).
The low plasma Apo-B100 and Apo-AI concentrations in the patients with Anderson disease were mainly related to low rates of production.
[show abstract][hide abstract] ABSTRACT: Low-density lipoprotein cholesterol (LDL-c) concentration is an independent cardiovascular risk factor, which mostly contributes to the development and progression of atherosclerosis. Results of randomized clinical trial with statins demonstrate that the optimal LDL-c target is < 70 mg/dL. The physiological range of LDL-c in hunter-gatherers and wild mammals, who do not develop atherosclerosis, is 0.5 to 0.7 g/L. No major safety concern was found in human with genetically-related low levels of LDL-c. A moderate increase in haemorrhagic stroke and diabetes was found in some trials with statins. Guidelines recommend to modulate the LDL-c target according to the level of the total cardiovascular risk.
[show abstract][hide abstract] ABSTRACT: Glucose intolerance and dyslipidaemia are independent risk factors for endothelium dysfunction and CVD. The aim of the present study was to analyse the preventive effect of n-3 PUFA (EPA and DHA) on lipid and carbohydrate disturbances and endothelial dysfunction. Three groups of adult hamsters were studied for 20 weeks: (1) control diet (Control); (2) high-fat diet (HF); (3) high-fat diet enriched with n-3 PUFA (HFn-3) groups. The increase in body weight and fat mass in the HF compared to the Control group (P < 0·05) was not found in the HFn-3 group. Muscle TAG content was similar in the Control and HF groups, but significantly lower in the HFn-3 group (P = 0·008). Glucose tolerance was impaired in the HF compared to the Control group, but this impairment was prevented by n-3 PUFA in the HFn-3 group (P < 0·001). Plasma TAG and cholesterol were higher in the HF group compared to the Control group (P < 0·001), but lower in the HFn-3 group compared to the HF group (P < 0·001). HDL-cholesterol was lower in the HFn-3 group compared to the Control and HF groups (P < 0·0005). Hepatic secretion of TAG was lower in the HFn-3 group compared to the HF group (P < 0·005), but did not differ from the Control group. Hepatic gene expression of sterol regulatory element-binding protein-1c, diacylglycerol O-acyltransferase 2 and stearyl CoA desaturase 1 was lower in the HFn-3 group, whereas carnitine palmitoyl transferase 1 and scavenger receptor class B type 1 expression was higher (P < 0·05). In adipocytes and adipose macrophages, PPARγ and TNFα expression was higher in the HF and HFn-3 groups compared to the Control group. Endothelium relaxation was higher in the HFn-3 (P < 0·001) than in the HF and Control groups, and was correlated with glucose intolerance (P = 0·03) and cholesterol (P = 0·0003). In conclusion, n-3 PUFA prevent some metabolic disturbances induced by high-fat diet and improve endothelial function in hamsters.
The British journal of nutrition 09/2011; · 3.45 Impact Factor
[show abstract][hide abstract] ABSTRACT: Pro-protein convertase subtilisin/kexin type 9 (PCSK9) is a post-transcriptional inhibitor of LDL-receptor. In non-diabetic men, plasma PCSK9 levels were found to be inversely correlated with low-density lipoprotein (LDL) apolipoprotein B100 (apoB) fractional catabolic rate (FCR). Here, we aimed to determine the effect of type 2 diabetes on the association between plasma PCSK9 and FCR of LDL.
A kinetic study of LDL-apoB100, using stable isotopes, was performed in 38 individuals (20 men, 18 women) including 23 non-diabetic normolipidemic subjects and 15 patients with type 2 diabetes.
In the non-diabetic group, plasma PCSK9 was positively correlated with LDL-C (r=0.64, p=0.001), apoB (r=0.67, p<0.001), and inversely correlated with LDL-apoB FCR (r=-0.61, p=0.002). In contrast, in type 2 diabetic patients, plasma PCSK9 was not associated with LDL-C, apoB and LDL-apoB FCR. However, the lack of association between PCSK9 and LDL-apoB FCR seemed to be limited to the patients with "uncontrolled" diabetes (HbA1c>7%) since a borderline significant negative correlation between PCSK9 and LDL FCR (r=-0.70, p=0.08) was retrieved in patients with HbA1c≤7%. In multivariate analysis, LDL-apoB FCR was independently associated with PCSK9 (p=0.001) and fasting glycaemia (log) (p=0.030) in the non-diabetic population and with PCSK9 (p=0.040) and HbA1c (p=0.029) in diabetic patients.
Our data indicate that both PCSK9 and glycaemia are independent factors influencing LDL catabolism. Plasma PCSK9 influences significantly the catabolism of LDL-apoB100 in individuals without diabetes, but not in patients with uncontrolled type 2 diabetes. Thus, the influence of diabetes on LDL-apoB FCR catabolism may overwhelm the influence of PCSK9.
[show abstract][hide abstract] ABSTRACT: Diabetes mellitus causes endothelial injury through oxidative stress involving reactive oxygen species and peroxides as well as inflammation, both of which consume antioxidant defenses. Singlet oxygen ((1)O(2)) is produced by leukocytes during inflammatory and biochemical reactions and deactivated by producing reactive oxygen species and peroxides. To determine whether serum was capable of deactivating (1)O(2), we triggered a photo reaction in sera from 53 healthy donors and 52 diabetic patients. Immediately after light delivery, dichlorofluorescein was added and then its fluorescence was recorded. The mean capacity of (1)O(2) or secondary oxidant deactivation was reduced in patients with diabetes mellitus. Hemolysis reduced deactivation of (1)O(2)-induced secondary oxidants in both healthy and diabetic patients. Body mass index, age, platelet counts, and blood cell numbers exerted a nonlinear influence. High levels of glycated hemoglobin were associated with an increased deactivation of oxidative species, whereas high-density lipoprotein cholesterol, total cholesterol, and the total cholesterol to high-density lipoprotein cholesterol ratio decreased the serum deactivation capacity. Oral antidiabetics bore no influence on deactivation, which was restored by insulin in women. Deactivation capacity was lower in women, who had half the complications found in men, suggesting that, with more severe diabetes mellitus, protection was maintained against complications. Resistance to (1)O(2) should be considered during the monitoring of diabetes mellitus.
Metabolism: clinical and experimental 04/2011; 60(9):1340-8. · 3.10 Impact Factor
[show abstract][hide abstract] ABSTRACT: Reverse cholesterol transport (RCT) is an anti-atherogenic process by which cholesterol is effluxed from peripheral tissues by high-density lipoprotein (HDL) and returned to the liver for excretion into the bile and faeces. Dyslipidemia is thought to impair RCT through higher triglyceride-rich lipoprotein (TRL), low HDL-cholesterol and higher activity of cholesteryl ester transfer protein (CETP), which transfers cholesteryl esters from HDL to TRL for further hepatic uptake. As CETP pathway would represent a major route in human RCT, we therefore investigated whether diet-induced dyslipidemia impairs RCT in hamster, a CETP-expressing species.
Golden Syrian hamsters were fed a chow or chow+0·3% cholesterol diet over 4 weeks. Biochemical parameters and in vivo VLDL-triglycerides secretion (Triton WR-1339 injection) were then measured. In vitro macrophage cholesterol efflux was measured, and in vivo macrophage-to-faeces RCT was also assessed after an intraperitoneal injection of (3) H-cholesterol-labelled hamster primary macrophages.
Cholesterol-enriched diet increased plasma total cholesterol (144%), triglycerides (101%), VLDL-triglycerides secretion (175%), CETP activity (44%) and reduced HDL-cholesterol/total cholesterol ratio by 20% (P < 0·01 vs. chow). Cholesterol-enriched diet significantly increased hepatic total cholesterol and triglycerides by 459 and 118% and increased aortic total cholesterol content by 304%. In vitro cholesterol efflux from macrophages to plasma was significantly reduced by 25% with plasma from cholesterol-fed hamsters. In vivo RCT experiments showed a significant 75% reduction of macrophage-derived cholesterol faecal excretion in cholesterol-fed hamsters.
Overall, these data demonstrate that diet-induced dyslipidemia severely impairs in vivo RCT in hamsters.
European Journal of Clinical Investigation 02/2011; 41(9):921-8. · 3.37 Impact Factor
[show abstract][hide abstract] ABSTRACT: In this review, the last data of the literature are analyzed to study the relations between weight, glycemic control and cardiovascular risk. The Swedish register of type 2 diabetic patients shows that a weight gain of one unit of BMI (Body mass index) increases significantly the vascular risk of 13%, an augmentation almost identical to a reduction obtained with a decline of 1% of HbA1c level. Several studies on the cardiovascular risk of diabetic patients produced similar data and underline the importance of maintaining the objective of weight reduction as an important point of the therapeutic strategy for these patients. Intervention studies to demonstrate the effect of the weight loss on the prevention of the cardiovascular events are in progress. This therapeutic objective is difficult to achieve or to maintain and has to use tools exceeding the simple dietetic approach to refer aspects of human sciences transposed on the medical world. In conclusion, everything must be made to avoid as much as possible a weight gain by the use of treatment with a neutral or positive effect on the weight excess within the limits of their efficiency.
Médecine des Maladies Métaboliques 02/2011; 5(1):55–59.

domain: literature


Agricultural insolvency figures outperforms other sectors
Farm businesses are less at risk of insolvency than a number of businesses in tourism, retail and property sectors, according to new figures.
The data from insolvency trade body R3 suggests that one in five farm businesses are at a higher risk of insolvency, although that figure is marginally better in the South West.
Figures from Bureau van Dijk's 'Fame' database suggest that 19% of farm businesses in Wales and the South East of England are under threat, as are 17% of those in the West Midlands and the North West.
Meanwhile 26% of London farm businesses have a higher than normal risk of insolvency, above the overall UK average for all sectors of 24%.
The rate of actual liquidation was recorded at 0.7% per quarter though, suggesting that businesses are combating the corporate insolvency threats against them.
Additional figures from the Office for National Statistics show that only 33 liquidations occurred in the agriculture, fishing and forestry in 2013 compared to thousands in manufacturing, construction and hospitality.
Meanwhile, only six farming businesses entered receivership in 2013, less than half of the total seen in the previous three years.
However, the figures are not as widespread as in other sectors, although large parts of agriculture adapted to the needs of the population.
“It is particularly interesting to see that agriculture currently has the lowest risk of failure across the whole region, especially considering the recent floods,” said Ross Connock, chairman of R3 in the South West and Director at PricewaterhouseCoopers.
“It is possible that many in the sector have adapted to a changing economic environment or looked to diversifying.”
Farmers can also look to the selling of large assets such as land, buildings and machinery, which means many can stave off insolvency before it reaches that stage.
Despite the relatively high rates of insolvency in other sectors, many businesses are reportedly more optimistic for the coming year given the recovering economic conditions.
By Phil Smith


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Page 89 text:
Girls’ Art—the creative course Any girl who is interested in creatively expressing herself may fulfill this desire through participation in the art classes. During the four year course offered at Cen¬ tral, students are given the opportunity of understanding the principles of good design, color, calligraphy, painting, drawing, cera¬ mics, and crafts. At the completion of her fourth year, each girl has also attained a strong background in art history, and fundamentals. Each senior student is given a week in which to exhibit her artistic achievements by arranging samples of her work in the display window on the second floor. Other artistic abilities of these art stu¬ dents are seen in connection with the oper¬ etta. These girls design the cover for the programs and make paper sculpture for advertisement purposes. Stress is on the principle that “everyone should use head, heart, and hands to make well, things that need to be made.” Through this course, every girl is given the oppor¬ tunity to further develop her talents for the glorification of her Creator. Left to right: J. Szmania, M. Widmer, B. Slota, M. Slomka, L. Kotlewski, N. Biggs. Page 85
Page 88 text:
Left to right: R. Buehrer, D. Venier, J. Amstutz, M. Schramm, W. Staley. Bovs’ Art—the artistic stufly The Boys’ Art Department offers the stu¬ dents an opportunity to express themselves individually. The freshman and sophomore years are devoted to the basic technique of lettering, sketching, color and design, while the junior and senior years stress the application of these techniques. Along with these funda¬ mentals, students are taught leatherwork, wood carving, and ceramics. Any student wishing to follow a career in art after grad¬ uation receives in this course his initial prep¬ aration through his study of interior decor¬ ating, crafts, oil, and water coloring. Aside from his ordinary classwork, a stu¬ dent is given the opportunity to make posters for the various activities, such as retreat, senior play, and operetta, which occur during the school year. These posters for the senior play (Mrs. McThing) and the operetta (Guys and Dolls) appeared in downtown and neigh¬ borhood stores, as well as in different parishes throughout the city. All interested students have the oppor¬ tunity to become members in the Catholic Art Apostolate, which aims to restore all things to Christ. Page 84
Page 90 text:
Library—the researcher’s haven “A storehouse of knowledge,” is a phrase which can apply not only to a description of the human mind but also to our school library. For in these rooms are located volumes upon volumes of books used by hundreds of students each day. Students refer to these books to attain information for science projects, term papers, book reports, essays and also to satisfy their reading enjoyment. The biography and fiction sections offer reading for leisure and enjoyment while the reference room, with its magazine and encyclopedia informations, will supply the answers to many research questions. Left to right: D. Wac, K. Siwa. Left to right; T. Brown, R. Szydlowski. Page 86
Suggestions in the Central Catholic High School - Centripetal Yearbook (Toledo, OH) collection:
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domain: library


text:
My place is close to Ibn Batuta Mall metro station. You’ll love my place because of the ambiance, the outdoors space, and the neighborhood. My place is good for couples and business travelers.
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domain: travel


text:
Title of Presentation
:"Landscapes of conflict, a Geographers Experience in Israel"
Date of Presentation
Name of Conference
Date of Conference
Location of Conference
Earth, Environmental and Geographical Sciences
Legg, Robert J., Landscapes of Conflict, a Geographers Experience in Israel, Gamma Theta Upsilon, Geo-scope, Geography Speaker Series, Marquette, MI, April 2011.

domain: geography


US drone technology company Department 13 has released an intelligent drone sensor system designed for civilian applications. The Detect, Identify, Attribute Locate (DIAL) system features sensors which passively listen for the radio frequency signature of drones that enter an area of operation. DIAL correlates signals against Department 13’s MESMER Enhanced Deployable Software (MEDS), a library of drone fingerprints built up over five years. Once a unique sUAS fingerprint is detected, DIAL sends alerts and logs a drone’s activity in Atlas, Department 13’s user knowledge centre.
Atlas maps the activity and allows the user to white list known drones and blacklist potential threats. Atlas can collect data from other detection platforms such as radar, lidar, acoustical and optical systems, and it integrates with autonomous security systems like the Nightingale Security Blackbird drone.
When Atlas and DIAL are combined with a drone management system, Atlas can correlate a live drone with its accredited operator and registered flight mission to deliver pre, post and in-flight operational awareness and audit functions to make site safety and audit easier.
For more information visit:


- Product groups
- Product development
- About B6
When punching, we can cut one or more items at the same time. A specially shaped knife is produced for the process, which is continuously pressed down through the given material. The material is "cut" in a razor-sharp line, which ensures that the end product is always uniform and accurately shaped. We offer cutting in virtually all polymer materials. These include foam, rubber, felt, textile and sound films - with and without adhesive. Moreover, we can handle items such as packaging, gaskets and acoustic panels.
We have long experience in the punching method. Over the years, we have found that it's a highly efficient manufacturing method that leaves items perfectly uniform with every punch. The punching process requires that a so-called punching tool is initially produced and developed for the given task. We have repeatedly experienced a high demand for such tools among our many customers, which is why we are routined in producing the right tool for the job.


Last week the folks at More Magazine invited me to cover their "Women in Hollywood" luncheon which is part of a day long "Reinvention Convention." They had a stellar panel including Cybill Shepherd (as moderator), S. Epatha Merkerson (Lt. Anita Van Buren from Law & Order), Polly Draper (Ellyn from Thirtysomething and the creator and Executive Producer of the Naked Brothers Band, Kate Mulgrew (Capt. Janeway from Star Trek Voyager) and Talia Balsam (Mad Men).
I really enjoyed the panel, but the problem was that some of the basic issues that effect women in Hollywood, especially film, were never touched on. So for me the panel was more like women who would love to work in films but can't because of their age and because there are no parts. They mostly all work in TV and in the theatre and that is where the work is for women.
I wish we could have addressed for the audience the importance of the lack of women's roles on the big screen and what that means for our culture, but because there was no big movie actress on the panel, there was no one to give the context.
Here are some interesting quotes from their conversation that I picked up:
Cybill Shepherd: I've been fortunate, I started in the business at the top and look like I've worked my way down.
Polly Draper: When Thirtysomething ended and I was not getting the movie parts so I wrote a part for myself. I wrote The Tic Code and it took five years to do. It's very difficult for women in Hollywood especially as they age for a variety of reasons. There aren't many roles written for women. The Naked Brothers Band was the first time I directed. Nickelodeon bought it and I am the showrunner, creator and executive producer. I am in a more powerful position.
S. Epatha Merkerson: All that has happened to me has happened in my 50s. I remember starting out and people saying you're not pretty. I've made my living as an actor. I've never lived in Hollywood, only in NY...3 years after Lackawanna Blues racked up all the awards and I went to someone with a project they said not too many people want to hear a story about an older black woman.
Kate Mulgrew: I heard you are pretty enough to be a leading lady and now in my 50s it's hard to say goodbye to that. The difficult thing for a pretty actress is to have to let go of the fact that that was ever important.
CS: The doors opened for me because of the way I looked but when I wanted to grow it was difficult.
S. Epatha: Maybe for me not going to Hollywood fortified me as a woman and an African American. I am the longest running African America on TV. Why is that?
Talia Balsam: We live in a celebrity focused world and that is harder to fight than age. They want me in my 40s to play the part of the grandmother.
PD: Movies have been made for 16 year old boys and now they are staying home on their computers. Maybe they will discover this audience of women.
S. Epatha: It is is happening on the small screen, Kyra Sedgwick and Holly Hunter. Even the Desperate Housewives. There are women heading shows on the small screen. We are questioning what is happening on the big screen.
KM: I learned something about the male demographic when I played Captain Janeway. They were quaking in their boots to put a woman in the (captain's) seat. It doesn't take a rocket scientist to figure out it's about sex. I didn't want her to look like someone they wanted to have sex with. I argued the fact that I didn't want her to have any sex as the first female captain because I was not going to run the risk of walking down the path that leading ladies have taken before -- to become a sexual object. I said I'm not going to do that because if I can't win them with my command, then I'm not the actress I think I am. But they allowed it. But the first question I am asked at every event is why didn't you have a love affair with Chakotay.
CS: I'm having a new flowering in film. I've done 3 films in the last couple of months. The largest budget was $3 million and one cost $700,000. The last one I just finished I shared a bathroom with the cast and crew - I was not happy - but I loved the experience working with young people and I'm getting better parts.
Best random quote from Cybill regarding the L Word: I got to play a love scene for the first time in 20 years and it was fun. It doesn't matter if it's a man or a woman - it's just how attractive they are!


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One of the nice things about wine country touring
is the opportunity to relax and enjoy the day. If you are unfamiliar with the Northwest
States or the Province of British Columbia, you may want someone else
to arrange your tour, or plan your own tour, but leave the driving to someone
else. In either case, this Tour Guides and Driving
Services section of Wines Northwest is set up to help you find these
Remember, even a small amount of alcohol on any given
day, can slow your reaction time. If you do not want to not appoint someone in your
party as designated driver, consider the fun of leaving the driving to a professional
-- a tour guide or driving service.
(Continue top of next column)
You may want to leave your car
at your lodging facility, at home or some other meeting place, after making arrangements
for a guided wine country tour, or for the driving services of one of the
companies listed in Wines Northwest. These services can be
acquired in many of the cities within or near wine producing areas of Northwest states.
Click on the
state region of your choice below to explore these listings. Or
check our Wineries & Merchant Finder for a more extensive,
alphabetical list of merchants, sorted by state. If you know of other wine country tour
guides or driving services, please contact us
and pass on the information.


Italian outfit Abstract Sounds have been serving up a generous helping of music production tools in recent years, mainly via Loopmasters and Loopcloud. Their sample packs have proved popular on the underground circuit, geared specifically at micro house and minimal. As the series has developed, the list of artists and labels using their content keeps on growing and they are often featured on production specific sites, the likes of Future Music and Music Tech.
As new artists continue to join the growing family, through their own offerings in tools and tunes, Abstract are now ready to release their first vinyl only. And a debut for the platform also makes a debut for the producer. Nerve Maze is releasing his first wax, a welcome follow on from his feeder sound mix put out earlier this year.
Maze starts off the series with four originals taking the name of the label. ‘Abstract 3’ on the premiere is a deep, Rominimal groover. Rolling bassline pulsates a fresh rhythm while a simple percussion directs flow. The never-ending beat captivates, but it’s the filtered down melody steadily trickling that shines.
Robotic samples whirl back and forth, breathing mechanical life through the groove. It sounds pleasant and it trips, keeping a cool vibe and a fun flavour.
‘Abstract 1’ is stripped back, subtle, minimalistic and eery in presence. The pace picks up into ‘Abstract 2’, drifting euphoric notes through a warm synth line and tapping hi’s. ‘Abstract 4’ reverts back to the deeper delve of sound, mysterious and adventurous, plodding through an unknown world.
From the first track to the last, Nerve Maze makes a journey that ends somewhere close to where it began. Mastering by Alexkid.
More info on Nerve Maze


ABILENE, Texas (KTAB/KRBC) – Abilene police are now investigating an early Tuesday morning home invasion.
According to police reports, victims reported that multiple suspects entered a home in the 200 block of North 13th Street at about 4 a.m., Tuesday.
The suspects committed assault with a deadly weapon, police said.
The suspects were not found and no other information was immediately released.
- Abilene nonprofit in search of more storage space for closet of medical essentials
- Eagles top Midland Lee; Cougars, Lady Bulldogs claim Southtown Showdown wins
- Alleged white supremacist arrested after ankle monitor puts him at Capitol riot
- Taylor County Jail reports no COVID-19 cases, unsure of when inmates can get vaccines
- Haskell Memorial Hospital overwhelmed with COVID-19 cases, sees 6 deaths in 6 days


Lee Myung-bak served as the 17th President of the Republic of Korea from 2008 to 2013. Prior to being elected president, he was a business executive, a member of the National Assembly and Mayor of Seoul.
President Lee was born on December 19th 1941. His family is originally from Pohang, a port city in southeastern Korea. He graduated from Korea University, majoring in business management. During his university days, he led a student democracy movement and was subsequently jailed for his activities by the authoritarian government at the time.
President Lee joined Hyundai Construction in 1965 and twelve years later became its youngest-ever CEO. During his time at Hyundai, he was involved in the construction of Korea's first highway, the building of Seoul's first modern apartment buildings and the production of Korea's first automobile which all became the foundation of Hyundai Motors, Hyundai Heavy Industry and Hyundai Shipbuilding. Today, Hyundai is one of Korea's largest companies and its brand is recognized throughout the global market; many of its companies are world-class leaders in its respective fields.
Some of the notable projects by Hyundai Construction under his leadership include the Arabian Repair Shipyard and the Jubail Industrial Port (both in Iraq) between 1976~1980, which was the largest single construction project undertaken by a construction company at the time. Later, he also built Malaysia's Penang Bridge, the second longest bridge at the time.
After a successful career as a business executive, President Lee retired from Hyundai in 1992 and entered politics. He was elected as a member of the National Assembly for two consecutive terms. Afterwards, he ran for Mayor of Seoul and was elected in 2002 and served until 2006.
While Mayor of Seoul, Lee restored Cheonggyecheon, a 6.5 km stream that ran through the center of Seoul, hidden under concrete and largely ignored for many decades. The stream was the primary source of traffic congestion in one of the world's most densely populated metropolis and also an environmental hazard. The restoration project has been hailed as a model for big-city ecological restoration and was recognized with a prestigious award during the 2004 Venice Biennale. TIME magazine named President Lee as one of the Heroes of the Environment in 2007.
When President Lee was elected president on December 19th 2007, he set a record in modern Korean political history by winning in all voting categories – region, age group and income level. The difference in the number of votes with the runner-up was 5.28 million, the largest margin in modern Korean electoral history.
After becoming President, he laid out a new vision called "Low Carbon Green Growth" which seeks to preserve the environment while achieving sustainable development. It is Korea's answer to today's global challenge. To this end, the Republic of Korea became the first country to pass the "Basic Law on Green Growth" and established the Global Green Growth Institute (GGGI) that is spearheading the global fight to present realistic solutions to a greener, sustainable future.
Another vision of President Lee was to make Korea a country that plays a more active role in bringing peace and prosperity to the international community. To this end, the Republic of Korea is also contributing to tackling the many global challenges that we face today, such as combating climate change, eradicating poverty, maintaining peace and achieving sustainable development. As the host of the G20 Summit in 2010 and the second Nuclear Security Summit in 2012, President Lee and the Republic of Korea was committed to working with others to ensure a more prosperous, more secure world for the next generation.
He is married to Kim Yoon-ok, and they have three daughters and one son and six grandchildren.


Technology is at its peak. Every day the world comes up with a different innovation that facilitates us in a unique manner. Microphones are one of them.
Choosing a microphone all depends on your personal preferences. There are multiple factors to take into account while purchasing the best microphone. There is no one general rule to apply but there is a range of types that you will find in the market. Each one comes with its own distinct characteristic. Here are some of them listed:
This dynamic microphone turns movement into electricity. The ‘dynamo’ mechanism is incorporated into the device. It produces and electrical signal that does not need to be powered. Offering durability and simplicity, these devices are popular in the market. However, you will have to compromise on the responsiveness feature.
These devices are often used for vocals in live sound. As capacitor microphones are heavy and delicate, dynamic microphones are preferred. However, these are relatively expensive.
This design historically had an internal amplifier which have a vacuum tube as its active element. Now we tend to see large diaphragm in these devices.
Advantage of using vacuum-tube microphone is that the amplifier creates less distortion producing present vocals. It can be a magical effect. These devices are popular and desirable in the market due to the advantages it offers but are comparatively expensive than other types.
This is a special kind of dynamic microphone with a metalized ribbon is a combination of coil and diaphragm. The ribbon is very light which makes it a more responsive device however the tone can be a little darker. It tends to produce darker sounds which makes it an ideal artistic tool to use in the studio.
These devices are fragile however it doesn’t need powering. But bear in mind that the output is generally low.
It is a special type of capacitor microphone which doesn’t need to be powered due to a polarized diaphragm. However the internal amplifier needs power. This often comes with a small battery but they are less sensitive and have a lower handling capability.
The latest designs have removed the limitation of materials by pre-polarizing the back plate.
In a nutshell, this type of microphone has a special mechanism of sound travelling though air. This works with piezo-electric effect where a unique crystal can be bended to create electrical voltage.
These days it is used as a contact mic. However, this device is entirely natural that is why it is only used when the advantages are prominent.
These were five types of microphones in the market. There are several more that you need to familiarize yourself with. Each one of them has a different mechanism and is has a distinct application. Knowing the sound textures of each of them is very important for composers and musician because it can even determine the success of your operations. So consider these relevant factors.


ORLANDO, Fla. - School safety is a major concern for parents in Central Florida following the mass shooting in Uvalde, Texas. Authorities in Orange County have detailed their plans to keep schools safe just as classes resume on Wednesday.
The Brevard County Sheriff's Office announced that its school resource deputies will carry rifles on campus to help better protect children and staff.
"Over the course of the past several months, parents, teachers, students, and communities across our country have all grown deeply concerned over school shootings, like the one in Uvalde, Texas," Sheriff Wayne Ivey said in a Facebook video.
In Marion County, authorities are also beefing up security. The Marion County Sheriff's Office said it will be adding a K9 to the School Resource Officer Division. Albi, a German Short-Haired Pointer, will join the ranks as the first firearms detection police canine in the county school system.
Albi, a German Short-Haired Pointer, will join the Marion County Sheriff's Office School Resource Officer Division as the county’s first firearms detection police canine. Together, Albi and her handler, Corporal Erik DeAngelis, will be patrolling our
- 'Unbelievably dangerous': Windermere residents concerned over all-night street racing
- Orange County commissioners approve rent increase cap question for November ballot
And in Orange County, Sheriff John Mina said his agency has access to over 6,000 cameras spread through the Orange County Public School system. There is also a resource known as the SafeWatch application through which school staff will be able to initiate school lockdown with the push of a button. Additionally, there are 196 school resource officers in Orange County who are prepared to deal with active shooter situations.
"They are trained to go in and end the threat immediately," Sheriff Mina said of school resource officers during a news conference on Monday.