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New data on first-in-U.S. trial sheds new light on success of gene editing and cell function
Genetically-edited immune cells can persist, thrive, and function months after a cancer patient receives them, according to new data published by researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn’s Abramson Cancer Center. The team showed cells removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion. Further analysis of these cells confirmed they were successfully edited in three specific ways, marking the first-ever sanctioned investigational use of multiple edits to the human genome. This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today in Science follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients’ immune cells. Penn is conducting the ongoing study in cooperation with the Parker Institute for Cancer Immunotherapy and Tmunity Therapeutics.
“Our data from the first three patients enrolled in this clinical trial demonstrate two important things that, to our knowledge, no one has ever shown before. First, we can successfully perform multiple edits with precision during manufacturing, with the resulting cells surviving longer in the human body than any previously published data have shown. Second, thus far, these cells have shown a sustained ability to attack and kill tumors,” said Carl June, MD, the Richard W. Vague Professor in Immunotherapy and director of the Center for Cellular Immunotherapies in the Abramson Cancer Center and director of the Parker Institute for Cancer Immunotherapy at the Perelman School of Medicine at the University of Pennsylvania and the study’s senior author.
The findings are the latest milestone in Penn’s history as cellular and gene therapy pioneers, including development of the first FDA-approved CAR T cell therapy, Kymriah, for pediatric and adult blood cancer patients.
Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, who is the co-lead author on the study along with Joseph A. Fraietta, PhD, an assistant professor of Microbiology at Penn. The co-senior author is Simon F. Lacey, PhD, director of the Translational and Correlative Studies Laboratory in the Center for Cellular Immunotherapies.
The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient’s T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell’s natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job.
“This new analysis of the three patients has confirmed that the manufactured cells contained all three edits, providing proof of concept for this approach. This is the first confirmation of the ability of CRISPR/Cas9 technology to target multiple genes at the same time in humans and illustrates the potential of this technology to treat many diseases that were previously not able to be treated or cured,” June said.
Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months.
Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors.
“Previous studies have shown these cells lose function within days, so the fact that the CRISPR-edited cells in this study retained anti-tumor function for a significantly longer period of time after a single infusion is very encouraging,” June said.
The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events.
CRISPR technology has not previously been tested in humans in the U.S. Investigators at Penn have pioneered a number of other “first uses” of engineered T cells over the past decade. Even with that experience, moving this work into the clinic while ensuring appropriate patient safeguards meant the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health’s Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn’s institutional review board and institutional biosafety committee. The entire process required more than two years.
Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn.
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A man who relived history to write about it
Dream dreams and write themm Aye but live them first.m Adm. Samuel Eliot MorisonSkip to next paragraph
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''I have no imagination,'' Adm. Samuel Eliot Morison once said. ''I can't write about a battlefield until I've been over it, nor about sea warfare unless I've taken part in it.''
Perhaps this modest admission by one of America's foremost historians best explains the admiral's innovative approach to his subject matter.
In the tradition of American historian Francis Parkman and Thucydides of ancient Greece, the admiral, who won seven battle stars in World War II, believed the only way to write history was to live it. Morison's research carried him around the globe - to the paradaisical West Indies, the stormy Straits of Magellan, and to war-strafed Normandy and Okinawa during World War II. Under sail, he retraced the stormy routes taken by Christopher Columbus, Ferdinand Magellan, and other New World explorers.
During his career, Morison wrote 48 books, two of which (his biography of Columbus, ''Admiral of the Ocean Sea'' and ''John Paul Jones'') were awarded Pulitzer Prizes.
Other prominent works include his 15-volume ''History of US Naval Operations in World War II,'' and ''The Oxford History of the American People.'' In the latter, Morison traced the major events in the nation's history from prehistoric times to the assassination of President John F. Kennedy.
In the preface to ''Admiral of the Ocean Sea,'' Morison declares, ''You cannot write a story out of these fifteenth and sixteenth century narratives
that means anything to a modern reader, merely by studying them in a library with the aid of maps. Such armchair navigation is both dull and futile.''
Four-hundred and fifty years after Columbus made his historic voyage to America, Morison decided to make history again by sailing the route as the leader of the Harvard Columbus Expedition. ''My attempt,'' he said, ''was to try to see through Columbus's eyes . . . just as if I had been beside him on the quarterdeck.''
In planning the Columbus expedition, Morrison drew upon nearly 20 years of ''armchair navigation.'' He hoped to authenticate the journey as far as possible. He sailed in a 140-foot schooner, which was designed to approximate the sailing conditions of Columbus's ships, the Nina, Pinta, and Santa Maria.
Morison described sailing up to San Salvador and seeing the same sight Columbus had seen 450 years before. Morison wrote in his log, ''Why, you can even figure out where he must have gone ashore. You don't know where he went ashore, but as a seaman, you know he just couldn't have gone ashore any place else.''
Dr. Henry Wade, Morison's colleague at Harvard, remarks, ''The Columbus enterprise could not have been made by just any old salt. In preparing for this journey a thorough knowledge of Latin, Spanish, Italian, and Portuguese was requisite because a tremendous amount of research had to be done in preparation for the sail and the book which followed.''
The end result was the writing of ''Admiral of the Ocean Sea.'' George Gloss, the proprietor of the Brattle Book Shop in Boston (which Morison used to frequent), says, ''This book and so much of Morison's work is a favorite with our clientele because he provides the reader with an intimate sense of time, place, and person rather than a docket full of statistics.''
Morison was, in fact, as much concerned with the character of Columbus as he was with the journey which changed the complexion of world history. In writing about Columbus, Morison explained, ''This dualism (the man of the Middle Ages and the modern man commingled in Columbus) makes the character and career of Columbus a puzzle to the dull-witted, a delight to the discerning.''

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It will be here before you know it! 88-9 WERS welcomes the Solid Sound Festival to North Adams, Massachusetts in the heart of New England June 26th-June28th! Two nights of Wilco and SO many more artists direct from the WERS playlist! (click here for more information)
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Georgia Nott, with her booming vocals, and Caleb Nott, with his impeccable synth skills, make up the brother-sister duo known as Broods. Broods are a New Zealand based and Lorde approved indie-electric pop band. The siblings’ debut album Evergreen is surely one to invest in if you have not done so already. The tracks […]
Jesse Dee, Live at The Sinclair. Click above for more details. Check out Boston artist, Jesse Dee at The Sinclair on May 28th. Full details for the show can be found here. Keep your eyes peeled for ticket giveaways.
Every Thursday afternoon at 5pm, we go “old school” with a set of music from some of the legends of rock!

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This material is protected by copyright and may not be published in whole or part without the expressed consent of Dr. Stein. However, it may be printed for limited classroom distribution, and quotes may be copied for inclusion in course papers and presentations.
The Origin of the Striving for Superiority and Social Interest1
By Alfred Adler
Chapter XII in The Collected Clinical Works of Alfred Adler: Volume 7
While it almost sounds like a timely problem to talk about striving for superiority and the roots of social interest, for Individual Psychology it is an old problem. The total value and meaning of Individual Psychology are contained in these two aspects and their solution. Our work has always emphasized these two elements, but we need to clarify their foundations to avoid any doubt about their meaning, which we sometimes find in our friends, but more often in our opponents. I do not think that what we mean by striving for superiority is very well known outside our group. We must add additional information to existing knowledge. This knowledge cannot be directly understood or found through an analysis of visible symptoms and facts, as something new is not generally found through analysis. In such a case we have the parts instead of the totality in front of us. The totality tells us Individual Psychologists much more than the analysis of the parts. Also, with synthesis nothing new emerges if one simply puts the parts together. Where shall we start our explorations, if we want to reveal what we have accomplished? In respect to the striving for completeness, or as it often appears, striving for perfection, striving for superiority, or as it has often been attributed to us by less intelligent writers: striving for power, some have always understood the real meaning, but not fundamentally enough to communicate this knowledge to a larger audience, or to clarify the fundamental importance this striving has in the development of the whole personality. Individual Psychology was first to mention that every individual has this striving for completeness. It is absolutely unnecessary to indoctrinate people with the idea so they can develop into superhumans, as the bold efforts of Nietzsche have shown. Individual Psychology has pointed out that every individual is aware of striving toward completeness, striving from lower to higher. Those who can read between the lines will have understood that we who practice Individual Psychology are constantly aware of the fundamental meaning of striving for superiority and that we uncover the typical direction of this striving in any disturbed person.
1 Originally titled “Über den Ursprung des Strebens nach Überlegenhei und des Gemeinschafsgefühles,” Aus einem Vortrag in der Wiener medizinischen Gesellschaft für Individualpsychologie. Published in the Internationale Zeitschrift für Individualpsychologie, Volume XI, 1933. 2 Translation by Sophia J. de Vries, 1990.
Nevertheless. I must answer a question which keeps reappearing every time this issue arises. Both friends and adversaries have questioned what probably was not quite clear in our group. Today, I will try to bring us closer to an understanding, because clarity for all is necessary.
In the first place, striving for superiority is innate. Not in a concrete way or as a drive, if there would exist a drive, which could later result in a good ending if nurtured, it is inborn as something that belongs to life, a striving, an urge, a development, something without which we simply cannot visualize life. Scholars, especially nature researchers, have always emphasized this principle in the physical development of man. Especially after Darwin, Lamarck, and others, it is a matter of course to keep the thought of development in mind. If here we take one step further and emphasize what was present in these researchers' minds, we may conclude that life means development. The human mind is alas too easily accustomed to translating everything that moves into form, not to observing the flow, but the frozen movement which has taken on solid form. From the beginning, Individual Psychologists have dissolved in movement what we perceive as form. As a result, we believe that to live means to develop. Everyone knows that the total human developed from one egg cell, but everyone should also understand correctly that this egg cell contains the foundations for development. How life came on earth is a question; maybe we will never find the final answer. We should consider how, for instance, Smuts has made a worthwhile attempt (Wholeness and Evolution) by assuming that life also exists in inanimate matter, a consideration modern physics comes close to when pointing out how electrons move around protons. We do not know if this conception will prove true in the future; however, our comprehension of life as movement cannot be doubted anymore, movement which goes in the direction of self-preservation, of increase, of contact with the outer world, of successful contact in order to survive. We must begin with this path of development, with a constantly active adjustment to the demands of the world, if we want to understand in which direction life leads and moves. We must keep in mind that this is a matter of origin, which is connected with the source of life. We need to overcome for the continued existence of the individual and the human race; we need to create a favorable relationship between individual and environment. This compulsive force to promote improved adjustment never ends. These concepts form the foundation of our understanding of the striving for superiority.
Possibly much of what I have explained here looks familiar to you and has been known by others. Nevertheless, Individual Psychology claims special credit for showing a connection and how this force, called “life,” develops in every individual. We find ourselves in the middle of evolution and notice it as little as we feel the earth revolving. Striving toward successful assimilation in the world is part of this cosmic connection. Even if we doubt that striving for superiority existed at the beginning of life, the progress of billions of years shows that even now striving for completeness is a fact for all of us. Furthermore, none of us knows the one correct road to completeness. Often mankind has attempted to picture this final goal of human development. So far, the best image we about this ideal elevation of man is the concept of God.3 No doubt the concept of God contains the same movement toward completeness as a goal, and it corresponds most closely with the dark desire of mankind to reach perfection as a concrete goal of completeness. Indeed, everyone has a different concept of God. Some images cannot come close to the principle of completeness; however, the purest expression of God succeeds as a concrete grasp of the goal of completeness.
Of course, people imagine this goal of completeness differently. We Individual Psychologists doctors, who deal with shortcomings in neurotics, psychotics, delinquents, and alcoholics, etc., also see this striving for superiority in them, but going in a different direction, contrary to intelligence, rather than as a correct goal of completeness. For instance, when someone tries to reach completeness by dominating others, we consider this goal already unfit. A goal of domination is no guide for the individual or mankind, because everyone cannot choose this direction; it would force him in opposition to the force of evolution; he would have to violate reality and protect himself, full of anxiety, against truth and all people who acknowledge truth. When we meet people whose goal of completeness is to lean on others, we consider this goal to contradict common sense. When someone finds his goal of completeness in leaving the tasks of life unsolved in order to prevent possible defeats, which would look like the opposite of completeness, this goal is completely inappropriate, though many people find it acceptable. Consider the question: what has happened to those people who chose a wrong goal of completeness for themselves and whose active adjustment has failed, because they went in the wrong direction and not toward advancement for all (see Alfred Adler: What Life Should Mean to You)? The extinction of species, races, tribes, families, and thousands of individuals who have left nothing behind teaches us the necessity for finding a tolerably correct goal of completeness. For every individual, the goal of completeness dictates the direction for the development of his total personality, movements of expression, outlook, thinking, feeling, and world concept. A direction deviating somewhat from the truth will result in harm for the individual, if not his ruin. It would be a happy discovery if we could know more about a correct direction, because we are embedded in the stream of evolution, which we have to follow.
Also in this respect, Individual Psychology has accomplished important work equal to its principle of general striving for completeness. Our many experiences have led us to understand the direction of an ideal completeness, namely, in the criteria of Gemeinschaftsgefühl, best translated as the social feeling of belonging and embeddedness.4 In regard to social interest, Individual
3Ernst Jahn und Alfred Adler: Religion und Individua psychologie. Eine prinzipielle Auseinandersetzung über Menschenführung. 1933 Verlag Dr. Rolf Passer, Wien und Leipzig.4 Translator’s note: Hereafter translated as social interest which is generally found in translations of Adler's works because there is no English word that covers the concept of Gemeinschaftsgefühl.
Psychology literature contains certain variations; that is why I want to talk about it. I don't want to talk much about the usual and silly mistake, sometimes made in our group by beginners and also outside of our group, as if what we call “social” means a contemporary specific circle or a larger group to which a person should belong. Social interest means much more. Specifically, it means to feel with all concerned subspecies aeternitatis, striving toward a form of community, which has to be conceived as eternal, as if mankind had reached the goal of completeness. It never has anything to do with a presently existing group or society, or with political or religious concepts. However, the goal that is most apt to lead to completeness means the ideal community of all mankind, the last fulfillment of evolution. Of course, people ask how I know this. Undoubtedly not from direct experience, and I will admit that those who find in Individual Psychology a touch of metaphysics are right. Some praise this aspect of our approach, some condemn it. Alas, many people have a wrong idea about metaphysics and want everything they cannot immediately understand excluded from people's lives. In doing so, we would curtail development, possibilities, and innovation. Every new idea lies beyond immediate experiences. Immediate experiences never create anything new. Creative thinking, when combined with immediate experiences, does create something new. Call it speculation or transcendental, every science ends in metaphysics. I don't see any reason to be afraid of metaphysics, which have influenced people's lives and development. We are not blessed with the absolute truth. That is why we are obliged to think about our future, about results of our actions, etc.
Our concept of social interest as the ultimate development of mankind has to contain the goal of an ideal society, because it is a situation where we imagine all life problems solved, all relationships improved, a goal that goes in a beneficial direction. Completion has to include the goal of an ideal society because everything we find worthwhile in life is a product of this social interest. I will repeat what I have worked out in another connection. The newborn child finds only what others have added to life, the contribution of our forefathers. This fact alone could inform us how life continues, how we can get closer to a situation with larger contributions and greater ability to cooperate, to a time when every individual functions as part of the total. Only the forms of cooperative movements in the direction of this ideal community will last. We do not want to pass judgment, but one thing we can say: a movement of an individual or a group can count as worthwhile for us only when it contains value for eternity, for the higher development of all mankind.
What happens to people who have not contributed anything? Disappeared, extinguished! The force of evolution, this impulse to reach a higher stage physically, intellectually, and spiritually, eliminates everything that does not participate or contribute anything. A ground rule in development warns the negative individual: go away; you don't understand what life is about! Thus, the eternal value of the contribution by people who have accomplished something for all becomes accentuated. However, we are prudent enough not to claim that we have the key to say correctly in every case what is and what is estimated as good for eternity. We know we may make mistakes. Only an objective exploration or events themselves can decide. At least it we can avoid what does not add to the striving for completeness. I could talk more about this completeness and show how all our functions are calculated so as not to disturb the society of man, but rather connect the individual with society. To see means to absorb, to fertilize what reaches the retina. Seeing is not only a physiological event, but also shows that man is part of the whole, who takes and gives. Through seeing, hearing, and talking we connect with others. Thus, all functions of our organs are correctly developed only if they are not detrimental to social interest. We talk about virtue and mean that someone participates; about vice and mean that he disturbs participation. Everything considered a failure is a failure because it disturbs the development of society, such as difficult children, neurotics, delinquents, or suicides. In all these cases participation is absent. In the history of man we do not find isolated individuals. Our development was possible only because mankind formed a society and in his striving for completeness included striving toward an ideal society. All man’s movements in the stream of evolution, express whether he has fond this direction toward an ideal society or not. Man is lastingly directed, obstructed, punished, praised, or challenged by the image of an ideal society, with the result that everyone does not merely have to account for every deviation, but also has to atone for it. That is a hard law, even gruesome. Those who have already developed a strong social interest are firmly determined to diminish the hardships of those who take wrong steps, as if they knew: there goes a person who has missed the correct road as a result of causes which Individual Psychology can point out. If people understood where they went wrong while avoiding evolution, they would leave the wrong road and follow the better one.
Finally, what about social interest; is that also inborn or do we have to instill it in people? Of course, it is inborn, but it can become developed only when the child is exposed to life around him. It unfolds in social association, in the same way that character traits are formed, however, in the limited way the child understands social relationships. The determining factor is the creative power of the child, guided by environment and education, as well as influenced by the experience of his body and how he appraises it. Considering the contemporary psychological state of mankind, and maybe also its physical state, we must evaluate the inborn foundation of social interest as too insufficient to develop and unfold without social understanding. Certain inborn faculties and functions operate almost completely on their own, for instance, breathing. We are not that far at all with social interest. We have not developed it in the same way as breathing; yet we have to expect the development of social interest as an end goal of completeness intensely enough that mankind will possess it in the future and use it as he does breathing. What we have to do in the present critical state is quite clear. No doubt this view offers us a sound foundation, not only for the evaluation of the individual and the education of children, but also for the improvement and direction of those who have failed. Of course, success requires explanation and understanding. We are not sure that every child or adult knows where he is going. It should be talked about long enough until perhaps in the course of thousands of years talking about social interest will be superfluous, like talking about correct breathing. Talking about social interest as belonging to the evolution of mankind, as part of human life, shows the fundamental importance and strength of Individual Psychology. Nowadays, everybody talks about society and social interest. Others have discussed it, but we are the first to strongly emphasize the fundamental essence of social interest. The concept of society and social interest can also be abused. But he who has understood correctly, knows that the essence of society and social interest contain an evolutional element that turns against everything contradicting this direction. He will avoid abusing society or letting himself be abused by others. The practical value and importance of Individual Psychology is that it has clarified the fundamental meaning of social interest for the improved development of the individual and all mankind.

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St. Louis Heart and Vascular is a full-service cardiology and vascular practice with five practice locations in St. Louis, St. Charles, and Bridgeton, Missouri, and Granite City, Illinois. SLHV Cardiology offers the most advanced, state-of-the-art diagnostic and treatment services in the St. Louis area — all in-house.
Unlike other practices that refer you out to clinics or hospitals for ultrasounds and CT scans, SLHV Cardiology offers the full gamut of both interventional and noninterventional cardiac services. In fact, SLHV Cardiology is the only private practice in St. Louis with an in-office PET scanner. Some of the services and state-of-the-art technologies they offer include both vascular and cardiac ultrasounds, coronary CAT scans, a catheterization lab, vein ablation, and echocardiograms.
The highly-qualified and exceptionally trained team of cardiologists at SLHV Cardiology, which includes some of the top-rated doctors in the region, are all board-certified with extensive training in their areas of expertise and numerous research papers to their credit. At SLHV Cardiology, the focus is solely on the patient’s care and well-being. The SLHV Cardiology team conducts comprehensive evaluations before developing effective, personalized treatment plans.
SLHV Cardiology has bilingual staff members that can accommodate patients from a variety of linguistic backgrounds, including Hebrew, Hindi, Punjabi, and Urdu. Call the office location nearest you to make an appointment.
SLHV physicians hold privileges at the following hospitals: Missouri Baptist Medical Center, Christian Hospital, Progress West Hospital, St. Luke’s Des Peres Hospital, Anderson Hospital, Barnes-Jewish St. Peters Hospital, and Gateway Regional Medical Center.

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NYC officials record second death in Bronx Legionnaires' outbreak: 24 cases tied to contamination from four cooling towers
- The New York City Legionnaire's outbreak has now reached two deaths and 24 total cases, officials report
- The cases have been tied to four Bronx cooling towers found to have been contaminated with bacteria that causes the infection
- Legionnaire's can not spread human-to-human, officials assure the public
- Officials report that the cooling towers believed to be at fault have now been sanitized
Two people in the Bronx borough of New York City have died from Legionnaires' disease after two dozen cases of the rare bacterial infection have been tied to contaminated cooling towers in the area.
The New York City Department of Health confirmed the deaths Wednesday, saying both patients were over 50 years old and had factors that put them at risk of severe disease.
Cases of the pneumonia have been detected in the Highbridge neighborhood of the city's most northern borough - which includes the region just next to the iconic Yankees Stadium.
Officials also confirmed that 24 cases have been confirmed as part of this outbreak, with four patients currently hospitalized. Four cooling towers that tested positive for bacteria that causes the disease have been sanitized.
The recent outbreak is one of the last things the city needed, with the Big Apple currently also being slammed by Covid, and leading the nation in positive monkeypox cases early in yet another public health emergency.
Two dozen cases, four hospitalizations and two deaths from Legionnaire's in the Bronx borough of New York City have been tied to four cooling towers found to be contaminated with bacteria that causes the rare infection
Legionnaires disease is caused by Legionella bacteria which can infect the lungs of a person who either swallows of breathes in water and air that contain it.
The bacteria occurs naturally in freshwater environments, the Centers for Disease Control and Prevention reports, but it becomes a danger when it finds its way into man made buildings.
New York City officials first detected cases of the pneumonia at the start of May, and announced eight cases and one death from the bacterial infection on May 23.
Days later, on May 25, the case count had increased to 25 and the city's health department announced that four cooling towers in the Highbridge area had tested positive for the bacteria.
Because cooling towers pour exhaust into the air, it is possible that these people inhaled contaminated air or came in contact with contaminated water in the area.
The infection kills around ten percent of people who catch it, according to official figures, but that mortality rate may be significantly lower because many cases are asymptomatic.
'While most people exposed to the bacteria do not get sick, Legionnaires' disease can cause severe illness or be fatal for those at higher risk, including people pre-existing chronic health issues,' Dr Ashwin Vasan, city health commissioner, said in a statement last month.
'That's why it's crucial that you seek health care as soon as you experience flu-like symptoms.'
Symptoms of the virus often initially match those of either the common flu or a mild case of COVID-19.
This puts extra stress on health centers in the city, as officials are recommending people who are feeling slightly ill to not only get tested for Covid, but for the bacterial infection as well.
Human-to-human transmission of Legionaries' is not believed to be possible.
Another public health emergency is coming at the worst time for the Big Apple.
The city's daily Covid infection figures are approaching 4,000 per day once again, continuing a gradual rise in the months since the winter Omicron wave ended.
Deaths from the virus have remained low, though, staying in the single digits since March.
Monkeypox has arrived in the city as well, though, with the Big Apple having recorded four of the 21 total cases in the U.S. - the most of any individual locality in America.

domain: medical


text:
Sedona Metal Rectangular Table
It may be hot outside, but you'll feel cool kicking back in our heavy duty, solid-cast aluminum furniture. Designed for style and built to last, this rectangular table features a durable charcoal black powder coated finish that will weather the harshest of outdoor conditions. Pair with the coordinating Sedona metal chairs for a matching set. Your very own outdoor oasis awaits you!
- Care And Maintenance
- Avoid placing in direct sunlight to reduce fading. As needed, use a mild soap solution to clean. Periodically apply a coat of quality liquid or paste auto wax to extend life of furniture. Storing during the winter and/or rainy season and covering when not in use is recommended.
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- Click here for assembly instructions.
- 18" H x 42" W x 21" D
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Investors, feed manufacturers see black solider flies as legitimate alternative fishmeal ingredient
The race is on to find a viable solution to the aquaculture industry’s dependence on forage fish. Growing demand for this finite resource means the days of cheap fishmeal and fish oil are long gone.
Plenty of contenders are sprinting toward a solution. Soy has widespread support. Other say the most promising alternative is microalgae, seaweed or microbes, or some yet-developed combination. But some industry insiders are betting big on bugs – and they have good reason to be hopeful.
“We’ve been tracking every insect company on the planet and we’re really excited,” said Amy Novogratz, managing partner of AquaSpark, a Netherlands-based “impact” investment fund that looks for ventures that have economic, environmental and social benefits.
Companies like Enterra, Entofood, AgriProtein, Ynsect and EnviroFlight are hoping to be the first to take wing. Crickets, weevils, grubs and mealworms are all being looked at, but most eyes are focused on the beneficial black soldier fly.
“The soldier fly is the answer,” said Entofood CEO Franck Ducharne. “It grows very quickly. Hatch to harvest is only 10 to 12 days.”
While the words “fly” and “maggot” can carry a pretty strong “ick” factor with consumers, these shouldn’t be confused with common houseflies. Black soldier flies don’t bite, sting or spread diseases. They’re high in protein, have a strong amino acid profile and are easily digested. Novogratz isn’t worried about the marketplace reaction.
“We think it would be an easy message for people who prefer a natural feed for their fish. Consumers don’t want a ton of information,” said Novogratz.
Thus far, tests on trout, yellowtail, turbot, yellow perch and other species have shown promising results. Rick Barrows, a research nutritionist with the U.S. Department of Agriculture’s Agricultural Research Service has been testing black soldier fly meal in rainbow trout diets.
“We just finished the growth phase of the feeding study with defatted [black soldier fly] meal. No fishmeal. And the trout grew just as fast as the fishmeal control group,” said Barrows. “There’s something in black soldier flies that’s highly palatable. Trout are eager to eat it.”
A use for wasted food
Right now, fish producers rely primarily on fishmeal and soy to meet feed requirements. Soybeans have lightened much pressure on forage fish stocks, but soy production requires a great deal of land, and most soy is grown in the United States, Brazil, Argentina, China and India. The rest of the world, including countries with robust aquaculture industries like Vietnam, Bangladesh, Indonesia and Norway, relies on imports.
For those looking for a lighter environmental footprint, it turns out that black soldier flies are more than just potential protein for fish. They’re promising powerhouses that can be used to help convert the 1.3 billion tons of food waste produced each year – an issue that’s gaining traction globally. Black soldier fly waste (produced after chowing down on all those food scraps) is valuable as compost, another checkmark in its column.
“Every country in the world has a need for protein and has food waste,” said Ducharne. While Entofood is currently based in Malaysia, Ducharne said its plan is to bring the technology to where fish production occurs. “We have a very important mission – to find a sustainable solution to bring to industry.”
But ask around, and you’ll find a few critical hurdles the black soldier fly still must clear. Two of the biggest? Scalability and regulatory approval.
“The plants we visited are secure and clean and impressive. The drawbacks? If they’re going to be able to scale fast enough. The largest companies focusing on black soldier flies are producing 5,000 metric tons annually. Most aren’t even at capacity. When you’re talking about the need for hundreds of millions of tons, you need a lot more investments and collaboration,” said Novogratz.
“The last five to six years we’ve been concentrating on the biology of the animal,” added Ducharne. “How to breed them and produce large amounts of eggs.”
Black soldier flies will never be as abundant as soy – the most abundant protein source on earth. But we need a high quality alternative ingredient that’s local.
He said it was the same problem facing the shrimp industry when it was in its infancy.
“The main issue then was the hatchery. Shrimp growers relied on wild postlarvae until the technology was mastered,” he said. “Here it’s exactly the same. The secret is to be efficient and strong in the hatchery part of the business.”
Ohio-based EnviroFlight has the technology to scale up and is focusing on its first major commercial plant, according to the company founder, Glen Courtright.
“We had to reinvent the wheel to scale the technology and make it commercially viable,” said Courtright. “There have been myriad challenges,” including a fire that destroyed the company’s mating chamber and a power outage during subzero temperatures that killed off much of his broodstock.
In February, the company was acquired by Intrexon Corporation, which formed a joint venture with Darling Ingredients, providing the financial backing the company needs.
EnviroFlight isn’t the only outfit ready to go big with bugs. According to ImpactAlpha, Canada’s Enterra Feed Corp. plant will have the “capacity to transform 36,000 tons of food waste each year into 2,500 tons of protein and oil and 3,000 tons of organic fertilizer.”
Still not enough to meet the $60 billion global animal feed industry needs, but a promising start.
What about omega-3s?
A bigger hurdle than scalability may be regulatory approval. Right now, the use of insect meal in agriculture and aquafeeds is still mostly prohibited in the United States and Europe. (In October 2015, the European Food Safety Authority published its first risk assessment of insects in food and feed.)
In the United States, the FDA will not approve a broad, undefined term like “insect meals.” Each insect-based product would have to be reviewed by regulators individually – a long and often complicated process. For example, a mealworm and a black soldier fly may have far different protein levels. Do they eat things that could accumulate toxins that might be bad for certain animal? Are they being fed pre-consumer food waste, animal waste or post-consumer waste? Substrate matters.
“What the insects are raised on is important. A lot of companies develop plans to take in waste and discount that,” said Richard Ten Eyck, an Association of American Feed Control Officials (AAFCO) board member. “The FDA is looking for feed-grade material, something that is OK to feed livestock. But they’re not real jazzed on the other stuff that may contain pesticides, heavy metals or things that might bioaccumulate.”
The closest to getting regulatory approval is the black soldier fly dried larvae.
“That one is up for an association vote in August, and once the association accepts it, if they do, then that would be OK to put in animal feed using [the approved] definition,” said Ten Eyck.
Courtright added that it’s important to remember that black soldier flies aren’t a silver bullet, but an ingredient.
“It’s an ingredient that’s part of an overall balanced ration,” he said.
Harvest the black soldier flies too late, and the chitin, found in the exoskeleton of insects, can contain nitrogen, which isn’t easily digestible. And while the flies contain many of the nutrients carnivorous fish need, they don’t contain the omega-3 fatty acid levels found in fishmeal and fish oil.
“You can boost omega-3 levels in black soldier fly larvae if you feed them an omega-3 feed stock. Whether that’s cost effective or not depends on the substrate we use – like seafood trimmings, for example,” said Courtright.
Barrows isn’t convinced the lack of naturally found omega-3s is a problem.
“We can replace fishmeal with other protein ingredients. What we’re looking for is good protein and good lipid ingredients,” he said. “Black soldier flies will never be as abundant as soy – the most abundant protein source on earth. But we need a high quality alternative ingredient that’s local. It’s definitely promising.”
Now that you've reached the end of the article ...
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California-based journalist Clare Leschin-Hoar covers food policy and seafood. Her work has appeared in The Guardian, NPR, Scientific American, EatingWell and many more. Follow her on Twitter: @c_leschin
BluWrap shipping technology can cut the seafood industry's abysmal food-waste statistics by dramatically extending the shelf life of fresh product. Company CEO Mark Barnekow's mission is to get fresh fish off airplanes and onto ocean-bound cargo ships.
A competition designed to drive innovation in aquafeeds has doubled its original funding goal and has attracted some of the biggest names in fish feed. F3 has also served as a catalyst for collaboration among feed manufacturers and ingredient suppliers.

domain: food


Re: Something doesn't fly right with this story
Radio links, GPS, accelerometers and compasses all work just fine in the rain . . .
3 posts • joined 4 Jul 2018
Oh dear . . .
You do realise that there are 6+ CAN busses in a modern vehicle ? and that they are not directly connected together . . . ?
You do realise that the CAN bus connected to the infotainment system is not the same one connected to the ODBII port, or the drivetrain bus, or the body control bus, or, or . . .
You do realise that there is a CAN (and other bus technologies, LIN, Flexray) bus router between the ODBII port and the internal CAN busses ?
Do you understand anything real about actual vehicle electronics architectures ? . . .
Very likely the telematics unit is connected via an IP/Ethernet network these days, probably to the vehicle central gateway . . . BroadR Reach ethernet being the current ethernet trend . . . all you need is a relatively cheap media converter to convert to 10/100 classical ethernet and it plugs into your laptop for wiresharking . . .
Modern vehicles have (will soon have) an ethernet switch onboard, a port of which is usually presented on the ODBII connector for manufacturing software download and dealer software update and diagnostics. Almost nobody actually uses CAN on the diagnostics connector any more for anything serious - it's too slow . . . but it is supported and legally mandated for emissions control diagnostics so that Oily Dave at the garage can tell you what's wrong with your car without access to dealer diagnostics kit . . .
There's a lot of change going on in the automotive industry at the moment in terms on onboard networking technologies, the security side of which leaves a lot to be desired . . . not that the existing technology set didn't also have its problems too . . .
Biting the hand that feeds IT © 1998–2019


text:
Monsoon is here and when it rains the petrichor reaches our nostrils making us hungry . It increases our cravings to eat yummy food. Going out and eating is risky due to spread of Covid -19 . It happened with me too so I made a delicious garlic bread at home maintaining social distancing. My bread had a little twist in it as along with the cheese I added plenty of vegetables in it to make it a wholesome snack. When the bread starts baking the aroma of butter, garlic and onions fills us the room. Also it tastes divine.
Table of Contents
How to make yummy garlic bread with vegetables stuffing –
- Take 2 cups all purpose flour
- baking powder – 1/4 tsp
- baking soda 1/4 tsp
- salt – 1/4 tsp
- sugar – 1/4 tsp
- 1 tablespoon curd
- 1 teaspoon butter or oil
Make a dough, rest it for 30 minutes.
Garlic bread seasoning –
- Take melted butter in a bowl , add oregano, chili flakes and minced garlic in a bowl , mix the seasoning. keep aside
Setting up the garlic bread for baking
When the dough is ready, roll it. Brush the seasoning in every part, add sliced cheese, sliced onions, and corn to it.
Then carefully lift one end the rolled base and stick to other end, layer it to semi circle. Stick it with the help of butter, apply the seasoning on top and add knife marks on top layer.
Baking the bread
- Bake it in oven for 15-20 minutes at 180 degrees.
- Or use a Tandoor or whatever option available. Grease the base with oil and cover the lid for 20 minutes on low flame. Do the toothpick stick check for confirmation.
Enjoy the cheese burst garlic bread hot with a warm cup of tea. Share your reviews in the comments section. Also check the recipe of homemade lemon pickle, it also is a source of B12 and boast immunity.


Modern technologies are developing in long strides. Already, we can afford a lot of convenient and practical gadgets. A simple phone or smartphone is able to replace a full-fledged computer, and this does not surprise anyone.
It would be strange if, at such a pace of technological progress, there were no attempts to create the most compact and functional gadget that would combine the qualities of a full-fledged smartphone and fashion accessory.
To say that the idea of a wrist phone is a real novelty is not quite right. Similar experiments and even finished products appeared before. Already at the beginning of the 21 century, we witnessed a very rapid development of the technology and entertainment industry. From the calculator built into the watch to the full mini-computer on hand, just a few years passed.
However, it should be recognized that such products are unlikely to be found on store shelves. It is not just outdated and quickly lost its relevance, but did not even acquire due popularity because it was far from perfect. In addition, almost all such models of gadgets were quite cumbersome as accessories, looked on the hand rather ridiculous, had limited functionality and worked on the buttons.
More recently, a futuristic bracelet with a built-in projector that not only translates an image, but makes it functional, seemed like something from the category of fiction. But as it turned out, it is quite possible to make such an accessory. Moreover, now you can see it on sale.
A smart bracelet, as it is sometimes called smart with a projection on the arm, looks like a simple silicone or plastic strap, on its surface there is a slight thickening, which contains the main technical “stuffing”. That is, it can be easily taken for the simplest bracelet, because it does not have too large dimensions, and on its outer surface there is no electronics like wires or switches.
Externally, the work of such a gadget can be easily confused with a futuristic hologram. Its main component is the mechanism projecting the screen of the smartphone on your forearm. However, unlike the standard non-volume hologram, the projection screen of the phone also has functionality! In other words, you can control your gadget directly on the surface of your hand, using the projected image as a full touch screen.
This feature is the main novelty and advantage of this development. Using a similar gadget, you do not have to remove your mobile phone or smartphone from your bag or pocket every time. Using a bracelet, you can directly control your technique, view and send messages, access the Internet, set up an organizer, and much more. At the same time, the control is easy and simple, because the projection completely imitates the familiar screen of a smartphone.
Deception or a new era of high technology
Needless to say that such a technological development had its own skeptics. At first glance, such a bracelet may indeed seem fiction, because to date the achievements regarding holograms and functional projections have not yet reached a new level.
However, the main developer of an unusual accessory, the company Cicret, has a lot of arguments and arguments that prove that the creation of such gadgets is really possible. There are no precise indications as to when they will go on sale and whether they will go at all. But today the most important thing is that such developments have ceased to be fiction and lead us into the present future.
A well-known developer of such bracelets has already conducted a collection of voluntary funds on crowdfunding platforms, which was very successful and allowed not only developing the technology, but also presenting the first working prototype to the world. Dispel doubts skeptics helps a complete analysis of the principle of operation of such bracelets.
The accessory itself looks like a regular fitness bracelet, in which all the technical “stuffing” is located in a small thickening located in the central part of the gadget. In this case, there will be special proximity sensors, an accelerometer, the projector itself, as well as additional modules like USB charging, as well as Wi-Fi or Bluetooth reception. In addition, of course, it provides a nutrient and complete external protection against any mechanical damage or water, which will be carried out at the expense of the base body.
The connection with the main gadget, that is, your smartphone, comes at the expense of Wi-FI or Bluetooth modules. To date, it is assumed that the bracelet will be able to support both modes, which may be necessary depending on the type of equipment used.
The projector will transmit data from the screen directly to the skin of the forearm carrier. Thus, you get the image of a familiar smartphone. To date, working prototypes demonstrate a fairly high-quality picture, which retains its richness and clarity even in daylight.
Such a “hologram” is controlled by reading the location of the fingers, which is provided by eight motion sensors. The data on the movement of the fingers is transmitted back to the smartphone, where they are recognized as standard touches to the touch screen, depending on which the image changes both on your gadget and on the projection.
As a result, you get complete control over your smartphone on the skin of your hand, which is very convenient and easy by design. The functionality is limited only by your gadget.
With the help of the bracelet, you can view images, read and send messages on social networks, set up an organizer, or even watch videos and run games.
There are no buttons on the surface of the bracelet. In order to activate it and start working, just shake your hand a little. The activation of the mechanisms occurs due to the reaction of the accelerometer, and in the same way it turns off.
Such an intuitively simple and at the same time functional gadget provoked a controversial reaction from potential consumers. Even now you can find a lot of not very positive comments about this development. The main points in the work of the bracelet, which cause skepticism, are the following:
- At present, there is no such nutrient that would occupy so little space and could guarantee the full-fledged work of the projector, sensors, receivers and other components;
- The real developments of holograms and similar technologies have not yet reached such a level of development;
- Until now, no photos, videos, real reviews of such bracelets have appeared;
- Custom-made bracelets that can be purchased online are a hoax.
In the prototype "wrist smartphone", which was demonstrated relatively recently, uses a rechargeable battery from USB. It really can not guarantee the continued operation of the projector and sensors. According to the developers, such a gadget can be in an active state of no more than 2-3 hours, but on the other hand, it does not imply too long work for it, like watching movies or a protracted game.
Such bracelets are not a complete hologram. They assume only the usual light design of the image on the skin, which is combined with the reading of the movement of the fingers. Technically, this is possible, because today all the necessary elements already exist. But the intended sensors do not have high accuracy, so the projected image and the controls on it must be quite large so that the reading of the movements can be correct.
Also important is the speed of data transmission via Wi-FI or Bluetooth. Miniature sensors that provide such a connection between a bracelet and a smartphone do exist, but the quality of communication provided by them may remain in question. For comfortable use of the gadget, you need the highest possible data transfer rate, so that the use of the projection completely simulates the touch screen without any delay.
The main reason why the overall impression of the development is spoiled is fraudsters. Now on the Internet you can find a lot of sellers who offer similar gadgets at a very high price. As a rule, after purchase, a simple silicone case will come to you by mail, at best, without all the technical “stuffing”.
In addition, even a commercial for a crowdfunding campaign made using computer graphics. The fact is that his task was to demonstrate the main idea of the developer, as well as the possible prospects of such a bracelet. Of course, the final result, taking into account all the technological nuances, can dramatically differ from the idea shown in the video, and this must be taken into account.
On the other hand, the developer has already managed to prove that the main functionality of the bracelet can actually be created. In addition, during the further development it is planned to complement the capabilities of the bracelet. For example, LEDs may appear in it to indicate the status, the presence of incoming messages and calls, as well as additional space for the memory drive.
There are still debates about how realistic it is to implement the final idea in its entirety. In the end, according to the developer of the bracelet phone, he should completely replace the touch screen of the smartphone. On the other hand, the gadget is a projection device, so you still have to carry the phone to which it is connected.
The development and production of smart bracelets is inextricably linked with the name Cicret. This company was the first to present the idea of such a gadget to the world, launched a promotional video on the Internet with a demonstration of a potential outcome, and also started a crowdfunding company, which, by the way, was quite successful.
In fact, the license for such technology belongs exclusively to this company. This is another reason to beware of various fraudsters, who may offer unique counterparts, more reminiscent of a rubber wrist watch under all sorts of non-existent “brand” names. Actually, it is best to follow the development and ready-made models of the "smart" bracelet through the official website of the company Cicret.
The main problem of technology, which can seriously undermine the possibility of its full-fledged publication, is a huge number of scammers. It is because of the massive frauds and high expectations that quite a few skeptics and negatively-minded consumers have appeared.
This can be quite a serious obstacle to the mass launch of bracelets in production, as the developer himself believes. It is also worth noting that Cicret initially stressed the technological difficulties, especially the need for serious software development, which, perhaps, to date, does not have any major IT-company.
That is why the final model that the company will be able to offer may differ dramatically from what we see on commercials. Nevertheless, the gadget can properly perform its main task and most importantly, accommodate all the stated technical modules, which in itself will be a serious step in the future.
Overview of existing gadgets
Many may be surprised or even alerted by the fact that there are no complete analyzes of such bracelets on the global network. Today you can find the official promotional video of the company Cicret or similar videos recorded by professional fraudsters.
We note right away that the video of the official developer was created to create a crowdfunding company and demonstrate the potential of such a technology, so it does not have a goal to fool anyone. Moreover, today this company has provided a novelty - the first working prototype of a smart bracelet.
Outwardly, he is practically no different from the one that was shown in the promotional video. The work of the projector is also credible, since the image on the hand can be seen quite brightly and clearly, while the developer demonstrated the work of the gadget in sunlight.
The functionality has noticeably changed. Moreover, the projected image now resembles a bright and stylized screen of a familiar modern smartphone. It is rather a simplified menu, in which the main role is played by large icons that allow you to read the message, go to the gallery, list of mobile contacts or organizer. This is due to the fact that at the moment the sensors for reading the location of the fingers do not yet have sufficient accuracy.
According to official Cicret, development is still in the process, so it’s too early to say that the company has completely failed. As you can see, in the prototype of the bracelet, at least the nutrient element, the projector, the motion sensors, the accelerometer, and the modules for data exchange are already successfully used. The main task now facing developers is to improve the software for better data transfer, so that the work of the smart bracelet complies with the model shown in the video as much as it is possible today.
So far, the official developer of the gadget doubts that it will be ready for massive sales in the coming year.
In order to get an impressive result, Cicret has yet to work. According to preliminary data, the finished bracelet will cost about 400 dollars.
Not the last thing that interests connoisseurs of technological innovations - the characteristics of the "telephone of the future". It is important to understand that any technology is developed taking into account the fact that it will have to interact with other elements that are currently available. Not only the convenience of the gadget itself depends on this, but also the relevance of certain phone models, software, operator cards, and more.
According to developer Cicret, the smart bracelet is designed to be perfectly compatible with current technologies that have become familiar to us. This is quite logical, because at the moment such a gadget is supposed to be in addition to the existing smartphone, and not its full replacement. Although it is worth noting, potentially this possibility exists, because in the bracelet it is planned to provide for a SIM card slot.
This “add-on” is suitable for any type of mobile phone that has a touch screen and supports the operating system like android or ios. To connect to the gadget, you will need to install a small software, which, most likely, can be obtained with the gadget or on the official website of the developer.
As mentioned earlier, such a gadget will be charged from a standard USB-module, and the energy will be enough for 2-3 hours of active work. It is assumed that in addition to designing the smartphone screen, it will also have additional memory, a vibration module notifying of incoming calls, messages, or any other important notifications, or a LED counterpart that can also display an indication of the device status.
A similar test model was offered on the website of the trooogooods implementer, who also supplied various “smart watches”. In addition, the bracelet can be supplemented with its own memory module or used in conjunction with your phone for receiving and making calls. It is also assumed that the opportunity to create a special secret key on the smartphone will be available, allowing you to block or activate the gadget to protect yourself from being used by unauthorized people.
As you can see, a smart accessory has mixed reviews for the time being. Basically, the first impression is spoiled by the massive appearance of fraudsters who managed to fool unsuspecting consumers, hiding behind the name of a real developer company. At the same time, Cicret presented a working prototype to the world, which looks quite impressive and opens up serious potential for further development.


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With three full weeks left in the 2017-18 NHL Regular Season, there is finally some clarity within the Metropolitan Division. After snapshot after snapshot where first place and last place where separated by less than ten points, a playoff picture is becoming clearer. All that had to happen was for some team to fall back a bit and the number of remaining games to fall between 10 and 13 for teams. A seven-point difference in January is not as huge as it is in mid-March.
Here is how the division looks after Saturday’s games:
The Washington Capitals are atop the Metropolitan for another week with a perfect week of results. Every point matters now. Just ask the Pittsburgh Penguins. They got five out of six and lost some ground on Washington as a result. It’s a two-team race for the top now.
Meanwhile, four teams in the East are effectively fighting for playoff spots: three in the Metropolitan and Florida from the Atlantic. Florida remains dangerous with games in hand, but the fall of the Philadelphia Flyers only invites more chaos down the final stretch.
As for the bottom three teams, well, only the New York Rangers announced that they would burn this season. Yet, they’re ahead of the Carolina Hurricanes and the New York Islanders. Like life, hockey is not fair. All three teams are far behind Florida such that it would take a miraculous hot streak to get back in the playoff picture. They’re the spoilers now.
Oh, and Florida slipped up a bit last week. They still have games in hand, but it’s welcome news for Philadelphia, Columbus, and New Jersey that they’re five to six points behind each of them now.
With that in mind, here is this coming week’s schedule. Games within the division, of which there are plenty, are highlighted in yellow:
In honor of Alexander Ovechkin scoring 600 goals in this past week, this week’s division snapshot will highlight the current active goal scoring leaders for each franchise that are on that team right now. All numbers and the identified players are from Hockey Reference.
Washington Capitals: Ovechkin with 600 goals. The 600 goal mark is an amazing achievement. Only 20 players have ever done it and Ovechkin is the first to have done so playing entirely in a salary cap era of the NHL. If there was any doubt, he is a first-ballot Hall of Famer and a modern legend of the game.
Washington had an amazing week to stay in first place. They won all three of their games. They prevailed over Winnipeg in overtime and then they smashed the Islanders in a home-and-home set. First it was 7-3 and then it was 6-3. Outscoring the same opponent by a combined 13-6 in two games easily proved who’s the superior squad. The Caps are by no means safe from Pittsburgh, but they have an edge with a one point lead from last week becoming a two point lead as well as a game in hand.
Washington will try to continue to take care of business in this week with four games coming up. They’ll have a big one within the division today at Philadelphia. The Caps will then go on to host a Dallas team who is battling for a wild card spot out in the West before easier (on paper) road games against Detroit and Montreal later in the week. Whether they’ll stay in first will depend quite a bit on Pittsburgh.
Pittsburgh Penguins: Sidney Crosby with 405 goals. Since Jaromir Jagr is no longer in the NHL, Crosby is the leader. It’s no surprise he’s the team leader. He’s been nothing but a point machine ever since he joined the NHL. What’s amazing is that it’s not so much he has a killer shot like Ovechkin (it’s still quite good), but he’s so quick and smart to get into places where he can finish the play successfully. The last decade plus has featured a Crosby-Ovechkin rivalry of sorts. It’s fitting that both are their respective active franchise leaders in scoring.
The Penguins were nearly perfect last week. Normally, that’s a good thing. In this past week, it cost them a little ground though. The Pens beat Dallas 3-1 to start the week. Their three games ended with a 5-3 win in Montreal. In the middle was the slip-up: a 4-3 loss to the New York Rangers in overtime. Yes, in overtime. So they earned 5 out of 6 points. In a week where their direct competition went 6 for 6, they’re now down by two in the battle for first place. So it goes in the Metro. At the least, Pittsburgh has pulled away from their in-state rivals.
The Penguins will look to keep up their good work in this week as they hope Washington slips up somewhere. The Pens will finally get to play on Tuesday in Brooklyn, after being off since last Friday. After the Islanders, Pittsburgh returns home to play Montreal on Wednesday and New Jersey on Friday. That New Jersey game will be a tricky one after two spoilers. But the Pens have something to play for and underestimating this squad is a foolish act.
Philadelphia Flyers: Claude Giroux with 206 goals. Giroux has been a dynamic forward of all sorts for Philadelphia. He racks up assists like few others in the league. But he can be and has been a finisher as well for Philly. Whether it’s in 5-on-5 or power play situations, #28 on Philadelphia is one to watch for. The fans know he’s been a stud forward for many years and he will continue to be one for many more.
The fans know that things have been bad for Philadelphia in recent weeks. After a fantastic February, they’ve had a miserable March. Once again, the Flyers won only one of their games in this past week. Once again, it came at the end of the week to avoid a winless one. In this past week, the Flyers lost to Vegas and Columbus before beating Carolina - all results in regulation. The lack of wins plus that loss to Columbus has opened up their third place position in the standings up for grabs. Instead of looking up at Pittsburgh and Washington and trying to make the race for first a three-team race, they’re now with Columbus, New Jersey, and Florida as they will battle for wild card spots. It’s a reversal of fortune and they’re reeling.
The Flyers will need to sort things out and fast. They’ll have a game today to get started on that; except it’s against a Washington team on a winning streak. The Flyers will have two non-playoff teams after facing the Caps. They’ll go to Detroit on Tuesday and host the Rangers on Thursday. Given that the Flyers have won all of two games in March so far, they can’t really look past anyone at this point. If they end up with one win out of three again, they’re going to start looking for a lot of help - and fast.
Columbus Blue Jackets: Cam Atkinson with 137. While Rick Nash is still in the league, he isn’t a Blue Jacket. Atkinson is and he typifies what Columbus is all about as a team. They have talent, they work hard, they put up solid numbers, and they’re tough to handle.
Right now, nobody is tougher than Columbus. The Blue Jackets have won seven games in a row. No other team in the NHL has won more than four at this moment. Columbus has surged up from being on the edge of the wild card to, well, being in a better spot. That speaks to the performance of New Jersey and Florida; the Blue Jackets could still find themselves on the outside if they falter. That didn’t happen last week: they beat Montreal, they beat Philadelphia, and they beat Ottawa. You couldn’t ask for better from Columbus from a division standpoint.
The trick will be in seeing how far they can take it. In this coming week, they have a tough back-to-back to start it. Both games are on the road and the first one is against Boston with the Rangers right after. Boston is one of the best teams in the NHL and the Rangers are proving to be effective spoilers. After that, the Blue Jackets will host Florida in a game that both teams would want to win at all costs on Thursday. Saturday night has the St. Louis Blues coming to town. Depending on how their week goes, they may be fighting for a shot at an active wild card race in the West. That makes for a tricky opponent. At the moment, it looks like Columbus can beat anyone. We’ll see how many they’ll beat soon enough.
New Jersey Devils: Travis Zajac with 166. While Zajac has never been known for being a significant producer, he has been utilized in a lot of situations in both ends of the rink. He has played with some excellent offensive talent over the years. As a result, he’s the leader. And it will take quite a lot of time and goals for Kyle Palmieri (75) and Taylor Hall (51) to reach him.
Currently, the Devils are halfway through a very difficult six-game road trip. So far, they have impressed by winning their first three games on it. In this past week, they only had two games and were at risk of falling out of the wild card spot just by a lack of games. But they received enough help and, more importantly, won their two games. The Devils absolutely embarrassed Vegas with a 8-3 win on their week. Yesterday afternoon, the Devils shutout Los Angeles, 3-0. You could not ask for much better than that. Problem is that they need to keep it up to stay with or get past Philadelphia and Columbus. The good news is: they can.
Despite winning their last three, their upcoming schedule for this week still is incredibly intimidating. They’ll visit a fresh Anaheim team that needs points for their own wild card race tonight. On Tuesday, they’ll visit a San Jose team that seeks to stay ahead of their California compatriots. At the end of the week, they’ll visit Pittsburgh on Friday and host Tampa Bay on Saturday in what may be their toughest back-to-back set of the season. Making matters worse: both of those teams have something to play for so expecting them to not take the game so seriously is not going to happen. If the Devils can come out of this four-game week with a positive record, that’s a huge gain for their playoff hopes. Still, Devils fans should still be scoreboard watching.
New York Rangers: Chris Kreider with 102 goals. Since Derek Stepan was dealt in June, the big man who loves charging the net is the Rangers’ franchise leader among current Rangers. That may not last as Mats Zuccarello is right behind him with 100. It may also not last if either becomes the next players to be dealt away as part of their re-building efforts.
Of course, if those efforts involved getting the best draft pick possible, then they took a hit in this past week. The Rangers nearly swept this past week of games. They beat up on Carolina 6-4 on this past Monday, they ended up winning in OT over Pittsburgh on Wednesday, and they lost in OT in St. Louis last night. Despite proclaiming they’re sellers this season, they’re now the closest team to Florida in the Eastern Conference standings. Unless they get some lottery luck, the Rangers will have to settle for closer to mid-round and late-round talent in the first round. Which isn’t a bad thing at all for this year; this class is supposed to be quite deep.
The Rangers can do some spoiling in the wild card race in this coming week. They’ll be hosting Columbus on Tuesday and visiting Philadelphia on Thursday. Expect other teams’ fans to watch those scoreboards; namely New Jersey and Florida fans. The Rangers will close out their week with a home game against a team that has been bad all season: Buffalo. The Rangers could end up being the best of the bottom three for another week by next week’s snapshot.
Carolina Hurricanes: Jeff Skinner with 200 goals. Skinner is a great skater, a great shooter, and a great forward on a team that has not always put it together. Skinner recently cracked the 20 goal mark for the fifth time in his eight-season career (and one year was a lockout-shortened season) and continues to be an offensive cornerstone of the current Hurricanes.
This past week was a punch to the gut for the Carolina Hurricanes’ playoff hopes for this season. They were within striking distance since beating New Jersey back on March 2. Since then, they’ve won one out of six games. This past week was winless and in a pretty decisive way. They lost big-time, 6-3, in Manhattan. They’ve had one of the worst third-period meltdowns in recent history in a 6-4 loss at home to Boston. Last night, they lost 4-2 at home to Philadelphia. Now in seventh, it’s going to take a miracle run just to get back in the wild card picture, nevermind take one of those two spots.
Carolina does have a relatively favorable schedule on paper for this coming week. They’ll be visiting the Islanders tonight, they’ll host Edmonton on Tuesday, they’ll host Arizona on Thursday, and they’ll visit Ottawa on Saturday. These are all teams that the Canes are ahead of in the standings. These are opponents that the Canes are arguably better than, with the potential exception of an Arizona team that has been better than thought in the past two weeks or so. Will the Canes make it a winning week? With the season they’ve been having - who knows?
New York Islanders: John Tavares with 267 goals. You know, Tavares has lived up to the lofty expectations he has had since being allowed to play major junior hockey when he was 15. Tavares has been amazing. He’ll continue to be amazing for another team as of July 1, 2018.
The Islanders have been spiraling down in 2017-18. They finally won a game last week. Their 5-2 win in Calgary snapped a significant losing streak. The losing returned when Washington pounded them in 7-3 and 6-3 results in a home-and-home set. Can a team that has fallen this hard even play for pride?
We’ll find out soon enough as they have four games coming up as part of a five-game homestand. They’ll host Carolina tonight, they’ll host Pittsburgh on Tuesday, and they’ll host Tampa Bay on Thursday. Those are three really challenging games. The Canes are a very good 5-on-5 team and both Pittsburgh and Tampa Bay are loaded with talent and have something to play for. That’s a bad combo for the Isles faithful hoping for some wins. On paper, their best chance for winning is on Saturday against Chicago. Given how things have went for the Isles, is that even going to happen? Again: who knows.
That was the week that was and the week that will be for the Metropolitan Division. There will be two more snapshots for this season. The final stretch is approaching and a lot can happen.
What do you think will happen in this coming week? Will Washington be able to retain first place over Pittsburgh? Who will take third place now that it is up for grabs? Who has the most to be worried about between Philadelphia, Columbus, New Jersey, and Florida? Can the Rangers continue undercutting their rebuild slightly with wins? Please leave your answers and other thoughts about the division in the comments. Thank you for reading.


In ion drive, we use ionized gas. With particle accelerators, we use high-energy particles. Given that colliders expend huge amounts of energy to propell a handful of particles, I speculate the particles can be used as propellant just like with an ion drive.
Given the higer energy output compared to ion drive engines, would that be possible? Is the energy source compact and not too heavy to offset the benefits? What if we experimented with light vs. Heavy particles and even ions?


text:
Fuerteventura All Inclusive
On the sea front and close to the beach, the popular Dorado Hotel is in an ideal location for a great holiday. Enjoy relaxing by the pool or be more active in the gym before heading out to the nearby resort centre to sample the local nightlife. Whether you are with friends or family you will be assured of a warm welcome.
- 350m from the beach
- 350m from Costa Caleta resort centre
- Snack bar
- À la carte restaurant
- 2 outdoor pools
- 2 children's pools
- Regular evening entertainment
Room facilities include flat screen television, wi-fi, safety deposit box, balcony or terrace, double cooking rings, fridge & kettle & microwave.

domain: travel


text:
Review: could Chlorhexidine gluconate cause Diabetes mellitus (Diabetes)?
Summary: Diabetes mellitus is found among people who take Chlorhexidine gluconate, especially for people who are male, 50-59 old, also take medication Aredia, and have Multiple myeloma.
We study 2,365 people who have side effects while taking Chlorhexidine gluconate from FDA and social media. Among them, 89 have Diabetes mellitus. Find out below who they are, when they have Diabetes mellitus and more.
You are not alone: join a support group for people who take Chlorhexidine gluconate and have Diabetes mellitus >>>
Chlorhexidine gluconate has active ingredients of chlorhexidine gluconate. It is often used in infection. (latest outcomes from 2,387 Chlorhexidine gluconate users)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin) has been reported by people with depression, bipolar disorder, high blood pressure, schizophrenia, stress and anxiety. (latest reports from 141,096 Diabetes mellitus patients)
On Mar, 31, 2015: 2,365 people reported to have side effects when taking Chlorhexidine gluconate. Among them, 91 people (3.85%) have Diabetes Mellitus.
Time on Chlorhexidine gluconate when people have Diabetes mellitus * :
Gender of people who have Diabetes mellitus when taking Chlorhexidine gluconate * :
|Diabetes mellitus||29.11%||70.89% |
Age of people who have Diabetes mellitus when taking Chlorhexidine gluconate * :
|Diabetes mellitus||0.00%||0.00%||0.00%||1.54%||1.54%||32.31%||36.92%||27.69% |
Severity of Diabetes mellitus when taking Chlorhexidine gluconate ** :
How people recovered from Diabetes mellitus ** :
Top conditions involved for these people * :
- Multiple myeloma (23 people, 25.27%)
- Depression (21 people, 23.08%)
- Pain (16 people, 17.58%)
- Bone disorder (15 people, 16.48%)
- Sleep disorder (15 people, 16.48%)
Top co-used drugs for these people * :
- Aredia (74 people, 81.32%)
- Zometa (74 people, 81.32%)
- Dexamethasone (40 people, 43.96%)
- Ambien (37 people, 40.66%)
- Levaquin (36 people, 39.56%)
* Approximation only. Some reports may have incomplete information.
** Reports from social media are used.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
Do you have Diabetes Mellitus while taking Chlorhexidine Gluconate?
You are not alone! Join a support group on :
- support group for people who take Chlorhexidine gluconate and have Diabetes Mellitus
- support group for people who take Chlorhexidine gluconate
- support group for people who have Diabetes Mellitus
Drugs in real world that are associated with:
Could your condition cause:
- A study of drug interactions between Metoprolol Tartrate, Lisinopril, HCTZ, Atorvastatin Calcium, Gabapentin, Effient, Pregabalin, Novolin R, Lantrisul, Isosorbide Mononitrate for a 61-year old woman with Blood Pressure Inadequately Controlled, Diuretic Effect, Blood Cholesterol Decreased, Neuropathy, Heart Mri, Fibromyalgia, Diabetes Mellitus Inadequate Control, Diabetes, Heart Rate Decreased. The patient has Diabetes Mellitus
- A study of drug interactions between Rosuvastatin Calcium, Metformin, Gliclazide for a 81-year old man with Diabetes. The patient has Diabetes
- A study of drug interactions between Oxycodone, Simponi for a 56-year old man with Back Disorder, Psoriatic Arthropathy. The patient has Diabetes, Musculoskeletal Discomfort, Upper-airway Cough Syndrome, Sore Throat
- A study of drug interactions between Lantus Solostar, Glipizide And Metformin Hydrochloride, Atorvastatin Calcium, Bystolic, Telmisartan; Hydrochlorothiazide, Amlodipine, Sitagliptin Phosphate for a 64-year old woman with Diabetes, Diabetes Mellitus, High Blood Cholesterol, Hypertension, Diabetes Mellitus Insulin-dependent. The patient has Hypertension, Diabetes Mellitus
- A study of drug interactions between Sertraline, LOVASTATIN, FINASTERIDE, Warfarin Sodium, Chlorhexidine Gluconate for a 74-year old man with Anxiety Disorder, High Blood Cholesterol, Prostatic Specific Antigen Increased, Mini Stroke, Mouth Sores. The patient has Blood Urine
Recent Chlorhexidine gluconate related drug comparison:
NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered.
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


text:
Dating marriage older woman
It is not your place to discipline an unruly child either, check his/her mom on that, and if it gets too much – call it a day and leave.
These children tend to be conscientious, ambitious, organized and—in relationships—dominant.If you and the woman are just trying to have sex then you should not be meeting her kids.In the current day and age kids know what the hell is going on and that awkward feeling you get when she forces 12 yr old Johnny to go to bed so you all can make out on the couch is warranted.You have to cater to both on some level, especially if the child is a female herself.Engage the child in conversation when he/she’s around but make it natural conversation, not forced conversation.Oldest females, on the other hand, are more likely to be bossy, confident and aggressive than their younger sisters.
Middles Middle children are the least defined of the types (there can only be one eldest and one baby, but middles shift depending on how many there are in the whole family).
Women you gotta be smarter than this, go back to his place, keep your kids out of it, and leave the little ones with a babysitter.
So go forth, date, have fun and remember when children are concerned you have to give respect in order to earn respect.
The single parent dilemma is felt the hardest by the children, and as a product of such a household I am lucky enough to have this insight in my dating life.
Many guys just don’t know how to deal with a child that isn’t theirs and it becomes immediately evident to the child, even when the mom is disillusioned into thinking that the guy is perfect.
Most teens are cynical and standoffish to new boyfriends so you have to expect hostility initially.

domain: sociology


New buildings in the UK consume far more energy than predicted by their designers - up to 10 times more according to an Innovate UK study. This performance gap doesn't arise because we lack technology. Studies by the UKGBC and others conclude that it's the result of failings throughout the project life-cycle, from concept to handover.
Performance gaps may arise because clients are unclear about what they want; project teams don't understand the impact of their design choices; contractors substitute products and materials on the fly and then install them poorly; or quality assurance is lax, with employers' agents either blind to the problems or willing to let shoddy work escape their net.
|What goes doen on paper often doesn't make|
it to bricks-and-mortar
That's a sobering realisation, because we've all drunk the same Silicon-Valley-brand of neoliberal Kool-Aid. We know that given the right market signals, some whizzy new technology that no one has yet thought of will appear and address any problem you can name: from climate change to… well, to the performance gap.
But not this time. Any purely technological solution would simply be papering over the cracks in our poorly functioning buildings, cracks that were put there by project teams.
There's a positive side to our realisation: if we don't need new technologies to close the performance gap, then we already have the tech we need. Indeed, I think we do. But, that technology must be used to empower clients, engineers and all of us on the project team to do our jobs better. Here's how:
The first step is to collect data from existing buildings. Organisations like CBx, Digital Catapult and Guru Systems, the company where I work, are already doing this. This data is being collected from utility meters (e.g. smart meters and heat meters), building energy management systems and other monitoring systems. By analysing this data, we can understand which factors have the biggest influence on performance.
We can then set clear performance requirements and explicit means of measuring them. These must be measurable before the building reaches practical completion, while the people who can put it right are still on site. It's no use specifying kWh/m2/annum or any other target that can only be calculated once the building is occupied. By the time they can be measured, the project team will have long since moved on. So, we must define requirements for the characteristics that are measurable before occupation and that lead to good performance in operation.
|Collecting in-use data from buildings rather than relying on projections is key|
Casey Cole is speaking on ‘Are you ready for a digital future?’ at the CIBSE Building Performance Conference on Thursday, November 17 from 10:25am to 11:20am.


Vineyard and Terroir
The Château Capion estate is a 45 hectare vineyard with a unique terroir. 200 metres up the Terrasses du Larzac, the land around its château, winery and wine cellar extends over three broad geological zones, the soils underfoot changing from Montpellier sandstone and clay to limestone gravels and alluvial silts. These habitats, the biodiversity present all around, and the climatic variations at Capion are nuanced in wines that express, in their power and finesse, their provenance.
To grow vines successfully, in-depth knowledge of the soil is crucial. With the help of soil scientists Claude and Lydia Bourguignon, every parcel of land at Capion has been studied extensively and the soil structures within our boundaries mapped. This allows us to know where the smallest variations lie so we might orientate our work accordingly.
Maintaining the vineyard means respecting the fragile ecosystem of the soil. It also means careful management of the vines. From the disbudding of a stump and the tying-in of cordons, to the work of intercourses and opening up the vine’s fruit area, everything is done by hand. Furthermore, the estate anticipated – and has advanced – its certification in organic farming. Since 2016, all phytosanitary products used at Château Capion are certified organic.
Syrah, Grenache, Cinsault, Mourvèdre and Cabernet Sauvignon are our red wine varietals; for our whites: Viognier, Roussanne, Vermentino, Chardonnay, Clairette, Grenache Blanc and Bourboulenc. Together, the average age of our vines is thirty years.


Preventive maintenance saves you money and protects your bottom line. And if you’re a do-it-yourselfer ready to roll up your sleeves and work on your own machine, it’s easy to order the exact parts you need to do preventive maintenance yourself.
Caterpillar offers Planned Maintenance (PM) Parts Kits tailor-made for your machine and maintenance interval, so you’ll always only buy what you need to make sure your machine is performing at its peak. There are Cat® Parts Kits for all the PM hour intervals recommended for your machine. These kits can be customized with the recommended parts and any optional parts you may need. And they come with a list of tools you’ll need for the job, a checklist of what to inspect and step-by-step installation instructions so you can stay organized while doing your preventive maintenance. Getting started is as easy as entering your machine’s serial number at the Cat website. Enter your serial number to find Planned Maintenance Parts Kits.