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Tony Zucco (Character)
from "Batman: The Animated Series" (1992)
- Fear in Shadows (2012) Played by Steve G. Broumas
- Bats in the Clocktower (2011) Played by Scott Pingel (as Zucco)
- "The Batman"
- A Matter of Family (2006) TV episode, Played by Mark Hamill
- "Batman: The Animated Series"
... aka "Batman" - USA (short title)
... aka "The Adventures of Batman & Robin" - USA (third season title)
- Robin's Reckoning: Part II (1993) TV episode, Played by Thomas F. Wilson (as Anthony 'Tony' Zucco)
- Robin's Reckoning: Part I (1993) TV episode, Played by Thomas F. Wilson
Jack Haley: You heard me, get out! I run an honest business here! I don't pay two-bit hoodlums protection money!
Anthony 'Tony' Zucco: Insurance, Mr. Haley, you know, from... accidents. Can't run a business without insurance.
Jack Haley: [grabbing a bull whip] Get off my property while you can still walk!
Anthony 'Tony' Zucco: Hey, hey, fine! I tried to be reasonable. You don't want my services? OK. But you're gonna wish you'd listened, old man. Oh, yeah, keep my number handy. You're gonna be calling Tony Zucco, and soon.
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domain: entertainment


As pharmaceutical firms try to market their products and reduce costs, vertically integrated structures hamper innovation processes. Yet, pharmaceutical firms must innovate to compete. Outsourcing knowledge intensive activities to knowledge process organizations (KPOs) serves to reduce innovation process obstacles. Grounded in diffusion theory and strategic management literature, this conceptual paper explores four interrelated strategic concepts: core competencies, economies of scale and scope, knowledge sharing, and learning. This paper claims that (a) accumulated core competencies of multinational pharmaceutical companies (MPCs) erode over time and these companies become dependent on KPOs (b) MPCs must understand how KPOs manage core competencies (c) economies of scope benefit KPOs enabling them to sustain competitive advantages for their MPC partners, meanwhile the benefits from economies of both scale and scope shift from MPCs to KPOs (d) KPOs need to monitor their rate of learning to remain competitive. The paper identifies implications for industrial managers and directions for future research.


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Background: In Manchester, approximately 120 women at > or = 1:4 lifetime risk of breast cancer have considered preventative surgery since 1992. Women treated within the Manchester protocol receive two genetic counselling sessions, a psychological assessment and a surgical consultation pre-operatively and annual follow-up post-operatively. The vast majority of women have breast reconstruction.
Methods: Since 1996, mental health and body image have been assessed in women attending annual follow-up using self-report questionnaires: the 28-item General Health Questionnaire (GHQ) and 10-item Body Image Scale (BIS). Women with high scores are assessed by clinical interview together with a proportion who have no significant problems.
Results: Between 1995 and 1999, 76 women completed surgery. Ten were awaiting post-operative review and 60 (91%) attended for follow-up of whom 45 (75%) were interviewed. Questionnaire data were available for 52 (79%) women, mean age 40.8 years (range 27-58). Six women were gene mutation carriers and of these three had had breast cancer. One additional patient was affected but had not been genetically tested. Eight (17%) of 47 women with assessments in the first post-operative year scored in the 'caseness' range on the GHQ: the mean GHQ score was 3.8 (S.D. 6.7), range 0-25. Results were comparable with those for women attending the Family History Clinic for risk assessment. The mean score on the BIS was 5.1 (S.D. 5.5), range 0-25, comparable with scores for women undergoing conservative surgery for breast cancer. Twenty-one percent of women reported no negative change in body image following surgery (i.e. zero questionnaire summary scores) and the majority of changes reported were of minor degree (item scores 0 or 1). The most frequently reported changes were in sexual attractiveness (55%), feeling less physically attractive (53%) and self-consciousness about appearance (53%): a third of women felt less feminine to a minimal degree. These results appeared stable over time. A minority of women had more serious psychological or body image concerns, usually in relation to surgical complications: they received further psychiatric intervention.
Conclusions: For the majority of women there is no evidence of significant mental health or body image problems in the first 3 years following Bilateral Prophylactic Mastectomy (BPM), but women who have complications warrant additional psychological help. Careful pre-operative preparation and long-term monitoring are advocated in this new field of cancer prevention.

domain: medical


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The YMCA of Greater Hartford celebrated its more than 160-year commitment to the city of Hartford with a grand opening and ribbon cutting ceremony featuring performances by teens from the YMCA Footlights Performing Arts Program at the all-new Downtown YMCA at State House Square on December 3.
"As a not-for-profit mission-based organization, YMCA programs and services impact thousands of people in Hartford every week. This move presents an exciting opportunity for us to expand our programs and services that promote Youth Development, Healthy Living and Social Responsibility. The Y's presence in the heart of downtown more than doubles our facility space, allowing us to meet the needs of the city's fast-growing downtown community," says Harold Sparrow, president and CEO of the YMCA of Greater Hartford.
Jade Marketing Group raised over $1200 at the event to benefit the Downtown YMCA's Footlights Performing Arts Program. The new Y will also house Read to Succeed, an adult literacy program and the Third Grade Swim program, which each year teaches more than 500 young people swimming and water safety skills to prevent drowning deaths among young people of color.
Pictured at the ribbon cutting celebration are youth members of the YMCA Footlights program in their festive red hats with Jerry Gooden, Chair of the YMCA of Greater Hartford Board of Directors, Lieutenant Governor Nancy Wyman, Harold Sparrow, president and CEO of the YMCA of Greater Hartford, Dovy Fruchthandler, partner of FBE Limited, Vicky Bullock, Member of the Downtown YMCA Board of Advisors, and Rick Hersom, executive director of the Downtown YMCA
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domain: sociology


https://content.iospress.com/download/journal-of-computational-methods-in-sciences-and-engineering/jcm200048 When this article was first published, the affiliation of all authors, concerning the Manipal Academy of Higher Education, was incomplete. Therefore, the correct affiliation of all authors is: Department of Mechanical and Manufacturing Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
All Science Journal Classification (ASJC) codes
- Computer Science Applications
- Computational Mathematics


text: Music has taken Natalie everywhere from coffeehouses to Carnegie Hall. Having sung a wide range of styles from an early age, she's never really fit into any category. The only thing that was truly constant was the music. She says, "If you had asked me as a kid, 'who are you,' I would have said 'a piano player.' But then I had an accident, and cut off a finger. In the process of sewing it back on and healing, I became a singer. I repeated back every melody I could hear. Eventually you get bored with the stuff you hear on the outside, and start singing the stuff you hear on the inside, and presto-chango, you are a songwriter." Originally from Colorado, Natalie started singing professionally at age 15, and in addition to the piano, she also plays guitar. "I have played and studied with some of the most amazing musicians on earth, and I am influenced by everything from Fred Astaire to Led Zeppelin and Alison Krauss. I believe that songs are polaroids of your feelings: emotional snapshots in time. So, it's hard for me to describe my music because there are moments you feel a little more bluegrass than hard rock. There are moments you feel more 'Faithless' than 'Lionel Ritchie'." As a result you can hear a range of influences in Natalie's music, held constant by her voice, which has been described as 'rich and mellow with sultry tones.' She says, "Overall my music is indie, but the recipe is 1 part country, 1 part rock, 1 part jazz, and 1 part orchestra." Because her musical background is very wide, she has sung everything from country to jazz, and R&B to "new classical" music. Janssen states, "I am drawn to new music, all kinds, and all styles. And most of the time, all styles of music borrow colors and expression from each other anyway, so it is very natural for me to sing many things. I always have." Of her music she says, "It's funny that I can usually express things through song long before I can speak them out loud. Songwriting has become my shadow, my therapy, my desire."

domain: artistic


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Arming people with accurate information is vital. Drillminister recently interviewed with English journalist Jon Snow on Channel 4 News [local British station] with the owner of AddressPollution.org about air pollution, how to check the air quality and the death of a nine-year-old named Ella Kissi-Debrah. The socially-responsible recording artist has a new song out called, ‘Choke’, that details and supports everything he talked about during his latest television interview! If you haven’t heard of Drilly or Drillminister, like Jaden Smith, he makes it his business to represent for the underrepresented, spread awareness, and influence change.
Would Greta Thunberg like the message in the music? Watch the music video below by the innovative British artist, Drillminister, to find out.

domain: news


Water policy and regulations are a source of many legal, ethical and moral arguments in the state of California. Utilities, agricultural interests, environmentalists, private landowners and other stakeholders’ interests create a complicated web when determining who gets what amount of water.
Steve Greenhut, journalist and author of Winning the Water Wars, talks about how the state can address its water issues by creating water abundance rather than managing water scarcity. He highlights how reframing the conversation can shift attitudes to create common ground between water stakeholders throughout the state. And he notes California’s experience with these discussions can become lessons for water scarcity in other states in the U.S.
- Intro: (0:00)
- Why research and write a book about Western U.S. water scarcity?: (0:44)
- What does creating water abundance mean?: (4:07)
- Unpacking the complexity of California water politics: (8:20)
- Using California as a model for ensuring water abundance nationally: (11:44)
- Weighing regional versus national water policy options: (15:27)
- Funding follows crises and how to place attention on water culturally: (22:15)
- Outro: (25:27)
Check out Steve Greenhut’s book “Winning the Water Wars”: https://www.amazon.com/Dealing-Drugs-Consequences-Government-Control/dp/0936488077
Watch last week’s video about the On-Site Chlorine Generation 2020 WWD Top Project: https://www.wwdmag.com/videos/site-chlorine-genearation-tai-po-wtw-2020-wwd-top-projects


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Reprinted from TFFX (2015, edd. al-Ayad, Matthey and Vitale) [purchase links] as part of our celebration of The Future Fire issue #50 in 2019. Four more years may have passed, but this history of the first ten years, and what we’re trying to do with the zine, still stands.
Issue #1 appeared in January 2005, after a bit of preamble and experimentation the previous year, and apart from a short hiatus to rest up and take stock about halfway through, we’ve been publishing an average of three to four issues per year ever since. We always wanted TFF to be challenging, experimental, progressive, inclusive, political, revolutionary—even if to start with maybe we weren’t sure what we were rebelling against!
The first thing you would notice if you went back in time ten years (or just used the Internet Archive’s Wayback Machine) to look at the TFF website in 2005, would be how god-awful-shitty the web design was. I like to think that’s aesthetics having changed, and it wasn’t quite so ’90s-looking to a 2005 eye, but I’m lying to myself. Still, the evolution from CBBC-quality flames in 2005, via a slightly darker, smoky aesthetic in 2007, to the cathode ray tube Unicode-soup we know and love today in about 2009, echoes the growing confidence we started to have in our niche in the speculative fiction market.
We launched in 2005 as a cyberpunk market (words like “chrome,” “postmodern” and “hyperfiction” peppered our tagline, manifesto and first story contests), but through an accident of community we knew more writers of horror and dark fantasy, and there was almost no conventional scifi in the first several issues. You can hear a bit of diffidence about this in our early editorials, and our craving for that elusive cyberpunk is almost tangible…
But once our slushpile was deep enough that we could reasonably select on genre and theme as well as quality (we were always uncompromising on quality) then our niche was under our control, and we didn’t have to be shy about the geeky, retro, techno-noir look we imagined for ourselves. Not that we ever stopped publishing horror, fantasy and surreal stories as well, of course; and never will.
You might also notice the evolution in our one-line mission statement: “New writing in Dark Speculative Fantasy!” we proclaimed in 2004. “Speculative Fiction, Cyberpunk and Dark Fantasy!” we boomed in 2007. “Social-Political and Speculative Cyberfiction!” we have cried since 2009. Always the line, “An experiment in and celebration of new writing” has sat somewhere in the first paragraph.
We’ve had a thorough turnaround of collaborators too: In 2004 we were Bruce, Joseph, Equus and myself; Joseph and Equus left within days; by 2009 we had been joined by Leoba, David, John and Lois; by 2011 it was just me, which is part of the reason TFF took a year’s hiatus. Now, as of 2015, we are joined by Regina, Kathryn, Tracie, Valeria, Cécile (who has illustrated stories since 2006), Serge; plus Lori and Fabio who have guest-edited anthologies and continue to be valued collaborators.
We have attracted a fabulous team of artists, a critical and generous cohort of reviewers, and a community of support that we plug into via social networks and occasional conventions. We’ve had a huge amount of support, both financial and in-kind, during the crowdfunding campaigns for the last three anthologies, and we engage both productively and cordially with several other small presses, publications and writing communities. In 2005 it was mostly me, sketching and photoshopping, reviewing whatever junk I found lying around, bribing and threatening people to send us their stories, funding the whole thing out of my pocket.
We hope to drive this success ever onwards. Our aim has always been to publish progressive ideas, underrepresented voices, socially important stories, and people clearly think that’s a worthwhile goal. We’ve learned a lot about what all of these mean over the years as well—learned to check our own privilege and be much more sensitive to issues of gender, race, class, ability, language, and so many other facets of oppression. We’re able to be selective now on features above mere quality, fit and taste; in addition we filter by features such as respect, not punching down, lazy stereotypes that we might have missed before we had such an inclusive team able to share their judgements of privilege and oppression with us.
But we’ve also always wanted to have fun, to push the boundaries, to play games that Borges, Kafka, Calvino and Eco would be tickled by, and people seem to enjoy that too. We feel it’s important to treat authors and artists with respect, which among other things means paying them properly for their work, and we have some ideas for improving our finances to do better on that front in the future.
But most importantly, my co-editors Valeria and Cécile have done a great job helping put together this anthology of old and new stories, and we hope you enjoy reading them. If you do, keep coming back to futurefire.net; we plan for there to be plenty more where these came from!

domain: literature


Amazingly, they somehow found a way to shut down part of the legendary Broadway street […]
This is about the most fun you can have on a music video!
This may be one of the saddest and most powerful songs out there!
Check out this Classic Tim & Faith from 1997
Happy mother’s day! Check out this great song just for mom from Bull superstars Sugarland! […]


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Facilities provided to Staffs and local representatives to be stopped if Chaupadi practice is followed
The Tila Rural Municipality of Jumla district has decided to stop facilities and services provided to the local representatives and staffs if they are found to be following the Chaupadi Practices. The Rural Municipality has decided it during the meeting held on September 26 in chairmanship of Ratan Nath Yogi, chair of Tila Rural Municipality.
Chauupadi practices and untouchability has been made more strict along with the announcement of Chaupadi-free area. Rawatwada, Jogiwada and Dhimkot under the Tila Rural Muniipality has already been declared as Chaupadi-free village.
Vice chair Bishnu Maya Buda of the Rural Municipality said that the campaign is being made stronger internally and such practices are being de- motivated.
She added that such restriction to stop services and facilities to those who support Chaupadi can make the campaign more strong. The Rural Municipality will be operating various program for women empowerment to eradicate such ill practices.
Man Datta Rawal
Accused of Rape Arrested
The police arrested Marshal Roka, 28, of Ghorahi Sub-Metropolitian City-16, on May 31, 2023, on the charge of rape of a 32-year-old woman. The victim filed a complaint at District…
Complaint Filed Against Accused of Domestic Violence
Lilam Devi Mahato, 24, of Kaudena Rural Municipality-5, Motipur, filed a complaint at Local Police Office, on May 31, 2023, accusing her husband Binod Mahato, 26, and her father-in-law Jogindra…
Accused of Killing Arrested
Police have arrested Mohan Tharu, 22, of Rupandehi District Kanchan Rural Municipality-2, on the charge of intentional homicide of Anjani Tharu, 18, of Banganga Municipality-6 and Bam Bahadur, 70, Tharu…
Ten Years Imprisonment For Rape of Minor
The District Court has sentenced Ajay Rai, 19, of Chaudandigarhi Municipality-6 Beltar to 10 years imprisonment for the crime of rape of a 16-year-old girl. District Court Judge Navraj Dulal's…
A Year Imprisonment For Attempted Murder of Minor
The Bench of District Court Judge Krisha Prasad Subedi's bench, on May 31, 2023, has sentenced Indra Kumar Tamang,55 an advocate of Triyuga Municipality-12 Sunagavatol, to a year imprisonment on…

domain: law


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Do you need a taping for an upcoming audition? Are you lacking direction on how to improve your audition techniques? Do you want to work your material with a professional acting teacher and coach?
Allow BeComing Studios to direct, record and edit an audition taping for a low price.
Prepare a theatrical or film audition in a private session, available upon request.


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Last fall, repeatedly disgraced former Louisville basketball coach Rick Pitino filed a lawsuit in federal court, accusing Adidas of damaging his reputation. His argument was that he knew nothing about the conspiracy alleged by the FBI and that Adidas — which, like Louisville, had just terminated its contract with Pitino — damaged Pitino’s reputation by getting in trouble with the feds.
“Adidas knew, or recklessly avoided knowing, that Coach Pitinos’ reputation for honesty and integrity would be seriously damaged by the perception — even if unfounded — that he was involved with the illegal and wrongful payment of money to recruits, or on their behalf,” the suit alleges.
It was, emm, not an especially compelling argument and it was tossed out of court Tuesday by a judge who basically said if Pitino had a problem with Adidas he needed to work it out with them, the Louisville Courier Journal reported.
Hale did not issue a decision on Pitino’s claims but wrote in his order that there is typically a strong presumption in favor of arbitration, a mediation conducted by a third party outside of the court system.“Here, the facts underlying Pitino’s tort and contract claims are identical: both claims are based on Adidas’s alleged bribing of a University of Louisville basketball recruit or his family,” Hale wrote. “… Given this standard and the shared factual basis between the claims, the Court finds that the claim asserted here is ‘at least arguably covered by’ the Endorsement Agreement.”
Adidas had argued that, in the first place, Pitino may have had knowledge payments funneled to players, and even if didn’t, any fraudulent actions were directed at Louisville, not Pitino.
Pitino maintains he knew nothing about it.


In these conflict of laws cases, Apple fulfilled with conflicting Intercontinental judicial opinions: an Australian court docket determination conflicted with a Canadian courtroom decision over the copyrightability of object code. In IBM v. Laptop Imports, the Superior Courtroom of New Zealand then deemed these prior choices and sided While using the Canadian final decision in ruling that, Though object code just isn't an authentic literary function in its possess proper, it is a replica of source code in substance kind and as a consequence an infringement of copyright usually takes location if it is copied with no authorization of your copyright operator. This kind of legal conflicts afflicted not merely Apple, but all other computer software providers likewise, as well as conflicts remained unresolved right up until the creation of a global lawful routine embodied in even more adjustments to countrywide copyright guidelines, which in the end designed item code matter to copyright legislation.
Oct five, 2011 Steve Jobs has tragically died of most cancers. A short while ago retired CEO of Apple was a legend, he altered Apple, a business within the verge of bankruptcy of one of the biggest and many worthwhile corporations on the planet. Furthermore, he revolutionized numerous industries in the procedure, together with audio, telephones, pcs and tablets. This case will be the achievement of Steve Jobs as well as the worries going through his successor, Tim Prepare dinner.
The 5V output is in comparison versus a Zener diode and Command feedback and isolated via a transformer with two Key windings and one particular secondary. It employs the flyback diode clamp winding.
Apple has actually been criticized in excess of seeking to avert iPhone users from utilizing the Google Voice software by disabling it around the iPhone. Apple declined to approve the Google application for use around the apple iphone, saying that the application altered iPhone intended functionality, i.e., that with Google voice installation, voicemail is no longer routed towards the iPhone's native software Visible Voicemail but as a substitute is routed through Google's software, So "ruining" the iPhone person expertise.
RO Associates "considers growth of switching ability provides to generally be A serious alter in the ability supply layout region". They provided miniature twenty-kHz supplies, and inexpensive sixty-kHz supplies.
Cook can continue on to accentuate Macintosh? With Dock revenue are down for four consecutive yrs, organized to be able to continue to rule in apple iphone smartphones amid expanding Levels of competition from companies including Google and Samsung? It'll be a fresh generation Apple, iPad, go on to dominate the tablet market place, or new competitors, from your Amazon to Samsung, to steal, and also to reduce the share with the income? And will not prosper with Apple, Tim Cook, not Steve Careers in the helm? "Disguise
The IBM Personal computer AT power provide turned a de facto conventional for Computer system electric power provides. In 1995, Intel launched the ATX motherboard specification, as well as ATX power offer (in addition to variants) happens to be the standard for desktop Laptop or computer power provides, with factors and layouts generally targeted specifically with the ATX market place.
A typical linear ability supply employs a cumbersome electricity transformer to convert the 120V AC into a minimal AC voltage, converts this to reduced voltage DC with a diode bridge, and after that uses a linear regulator to drop the voltage to the specified level. The linear regulator is a reasonable quick-to-use transistor-based element that turns the surplus voltage into waste heat to generate a steady output.
These are literally not a whole lot unique overall. Every puts AC into a transformer, then rectifies and regulates the output. The crucial element efficiencies of the switching supply is in Each and every of these methods: it uses Considerably bigger frequency AC to ensure that a scaled-down transformer with significantly a lot less Main decline can be employed, and it varies the input AC waveform to regulate the output instead of generate a set raw output and throw absent the excess through resistive decline.
It contained 7 H7420 electrical power provides and about 33 specific switching regulator units, as well as a linear regulator for your CPU that employed -12V DC at 490A.
As a result, creating the ability provide controller gets to navigate to this site be as much a issue of programming as of hardware structure. Electronic electrical power management allows electric power supplies talk to the rest of the system for larger performance and logging. When these digital technologies are mostly useful for servers now, I expect they'll trickle right down to desktop computers sooner or later.
Possibly not very truthful to assert Astec was minimal-recognized, they made modulators that took online video and audio (on some modules) and mdoulated the sign on to a provider wave to make sure that they might be exhibited over a Tv set acquire just plugging it to the aerial socket on the Television set.
Marvelous piece of do the job, with insightful and useful reviews by quite a few posters. Quite insightful. I wound up below as a consequence of my confusion more than what Isaacson said concerning the electrical power source with the Apple II in his biography of Steve Careers, plus the collective knowledge on Exhibit right here clarified the problems. Thanks.
Philips' first all-strong-condition significant-display screen a hundred and ten degree colour TV was the 'K9' chassis, introduced mid-1972 employing a hot-chassis style with buck-regulator at eighteen kHz. For a range of factors, a sizzling-chassis set wasn't satisfactory For brand new Zealand and Australia so a 180W flyback convertor was built using the identical Handle-module (based upon usage of SCS equipment). This mains-isolating flyback convertor was initial put into mass output in New Zealnd in the course of March 1973, followed by Australia a few 12 months later on.


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Following comments that the comedian made on Instagram, where she said she was “triggered and traumatized” by the incident, she discussed the controversy during her Amy Schumer & Friends comedy show at The Mirage Theater in Las Vegas over the weekend. It was Schumer’s first public appearance since the awards ceremony, which she hosted with Wanda Sykes and Regina Hall.
“This is my first time doing a headlining show since I was pregnant. I am so excited, it feels so good to be back in Vegas,” she said, per Billboard. “We’re gonna talk about everything and the Oscars but I just want to talk about drinking because I have been drinking so much and I am severely hung over.”
Schumer took a more serious tone when discussing the slap. “I don’t even know what to say about the Oscars,” she said. “I have no jokes about it. All I can say is that, I don’t know if you saw this, but Will Smith slapped Chris Rock. Did that cross your newsfeed?”
She went on to explain that the night had been going well until that moment. “I was kind of like, feeling myself,” she said. “I was like, ‘Oooh, somebody’s monologue went well.’ And then, all of a sudden, [Smith] was making his way up and just [motions a slap].”
She called the incident “just a fucking bummer.”
“All I can say is that it was really just sad. It says so much about race, about toxic masculinity, it’s just, everything. It was just really upsetting,” Schumer said.
Since that fateful night at the Oscars, Smith apologized to Rock on Instagram and later resigned from the Academy of Motion Picture Arts & Sciences. However, the Academy is still pursuing an investigation into the matter and there may still be some “consequences” that Smith has to face.


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Dan Zanes was a member of the popular 1980s band The Del Fuegos and is currently the front man of the Grammy-winning group Dan Zanes and Friends. His reincarnation in children’s music happened after Zanes began playing music with a group of other fathers in West Village playgrounds who were also there with their kids. Grownups and kids loved it! The who’s who of the music world started making guest appearances on his CDs, like Sheryl Crow and Suzanne Vega. In 2007, Zanes received the Grammy Award for Best Musical Album for Children for Catch That Train! In early 2009, Zanes\' ¡Nueva York! won in The 8th Annual Independent Music Awards for Best Children's Music Album.
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Like a good neighbor, spacemountain is there.
GeneralChack is a real enthusiast when it comes to collecting things. Pokemon was only a gateway hobby for him.
stupidfuckhead sounds like he has low self-esteem. Hey, cheer up guy!
If RolandTower was a cake, I bet he'd be delicious.
[sauntering up to joss whedon giving magazine interview] Hey are these guys bothering you
Internment Camp Queens Caught Scamming Extra Servings Of Water And Laying Around All Day In Government-Provided Housing
Two wonderful new games let you jump into meat grinders and walk into cactii.
Ben Garrison's Cartoons explained; Part 2!
Photoshop Phriday showcases the tremendous image manipulation talents of the Something Awful Forum Goons. Each week they tackle a new theme, parodying movies, video games, comics, history, and anything else you can think of. If you want in on the action, join us on the Something Awful Forums!

domain: hobby


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La Liga side Valencia eye move for Newcastle defender
One of Newcastle highest-profile defenders is being courted by Valencia, the La Liga side are eyeing a move for the ace as...
August 30, 2019 14:59
Newcastle United FC
Liverpool’s summer signings rated: How have Brendan Rodgers’ £117m worth of talent fared this season
As Liverpool’s season ends in a whimper following the damaging FA Cup semi-final defeat to Aston Villa on Sunday, it seems like...
April 21, 2015 7:10
(Image) Liverpool Summer Signings Take WAGs On Night Out After Humiliating Defeat To Aston Villa
Liverpool stars don’t dwell on defeat ....
September 14, 2014 13:52
Football News 24/7
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Latest Featured News
Video: Steven Gerrard sent off at half time for Rangers vs Livingston as he loses it with John Beaton
We all know that referees have a very difficult job, but the officials in the Scottish Premiership really do make it look...
March 3, 2021 19:09
Opinion: 5 alternative striker targets after Erling Haaland’s brutal Chelsea transfer snub, including clinical PL duo
March 3, 2021 14:17
Pics: Kevin-Prince Boateng’s unbelievable WAG Melissa Satta leaves little to the imagination in jaw-dropping Instagram lingerie snaps
March 2, 2021 23:05
Chelsea legend reveals why he’s already “annoyed” at Thomas Tuchel as he urges players to “have a private meeting”
March 2, 2021 13:37
“I think it’s something United would consider” – Man Utd tipped to try potential swap transfer
March 2, 2021 9:30
Pics: Juventus star caught red-handed appearing to stare longingly at gorgeous DAZN reporter’s backside
March 1, 2021 16:38


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Malayalam film industry's most famous actor Mammootty is geared up to see his latest film "Praise The Lord" hitting the big screens on 14 March. Fans are excited as this is one of Mammooty's much awaited films of the year.
This film is helmed by Shibu Gangadharan and it depicts Mammooty as a farmer named Joy from Palai, Kottayam. "praise The Lord" is Shibu's debut movie as a director as he has only assisted other directors previously.
The film is based on a literary work with the same name, written by Paul Zacharia, a Malayalam short story writer.
In the movie, the role of Mammootty's wife is played by Reenu Mathews, who was paired with him for his another movie "Immanuel" (2013).
The story revolves around Joy, who is a rich farmer with certain ideals. He is known to be a man who does not believe in love. Initially, he is against the concept of love, but certain instances make him a new man. A love story is brought into the plot and somehow the lovers are able to change Joy's perception of love.
Apart from "Praise The Lord", Mammootty has been busy off late with his other upcoming movie titled as "Gangster."
We now have the latest news that the film shooting has been wrapped up. Aashiq Abu, the director of the film, made this announcement on his official Facebook page. Along with this, he also mentioned his gratitude to Mammootty and all his crew members for their hard work. He gave a special mention to his assistant directors and said that they are the ones behind the success of this film. The director also announced that "Gangster" will hit the silver screens before Vishu (Malayalam New Year).
In "Gangster," Mammootty has a new avatar as he plays the role of a don. The filming for the movie was done mostly in coastal areas such as Goa, Kochi and Mangalore. Apart from these locations, the director also covered Rajasthan for some parts of the film. All this was done in just a span of 50 days. More updates from the director is expected to be out soon.


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Raw airs tonight (June 21) live from the ThunderDome in the Yuengling Center in Tampa, Florida. This is the first Raw episode during the four week build towards the upcoming Money in the Bank 2021 event on July 18.
Lashley and McIntyre need new opponents
Bobby Lashley and Drew McIntyre need new opponents after settling their war with a roll up inside Hell in a Cell.
Yeah, Hell in a Cell really ended with a roll up.
Several past Hell in a Cell matches have had truly brutal finishes. Batista nailed Triple H with a spinebuster on the steel stairs in 2005. Triple H pedigreed Chris Jericho on top of the cell in 2002. Undertaker chokeslammed Edge to hell in 2008. Jeff Hardy was taken out on a stretcher in 2018.
Then there’s Bobby Lashley vs. Drew McIntyre, which ended with...a roll up. McIntyre was busy trying to stop MVP from interfering for the billionth time, so Lashley just rolled him up from behind, got the three count, and bolted from the cage.
That’s what happens sometimes in pro wrestling. The heel found the lamest way possible to keep his title and get out of Dodge. At least this Hell in a Cell finish didn’t include a hologram, a no-contest, a hanging, or whatever the hell that garbage was with Seth Rollins and The Fiend in 2019.
Now that McIntyre can never challenge Lashley for the WWE championship ever again, both stars need some new opponents. Given MVP’s recent segments with Kofi Kingston, Kofi stands out as the obvious next man up to challenge Bob.
As for Drew, who really knows which heel will come after him next? Maybe WWE will throw him into a Money in the Bank qualifying match and simply forbid him from cashing in the briefcase on Bob.
The title scene
It’s a good thing that Mandy Rose and Dana Brooke got into a scuffle with Natalya and Tamina last week, because it’s hard to find any other women’s tag teams in WWE. But Natalya beat Mandy last night on the Hell in a Cell pre-show, so it’s not clear that the Sexy Muscle Friends deserve a shot at the Women’s tag team titles.
Nothing was settled at Hell in a Cell when Rhea Ripley retained the Raw women’s championship by getting herself disqualified in a match against Charlotte Flair. It’s clear that Flair deserves a rematch, but Nikki Cross is hanging around on the periphery with a decent case that she deserves a title shot too.
AJ Styles and Omos are on a collision course with the Viking Raiders over the Raw tag team titles. Given the way Omos manhandled Erik and Ivar in last week’s six man tag main event, I don’t like the vikings’ chances whenever this fight actually goes down.
Sheamus is dealing with a broken nose, but he refuses to vacate the United States championship. Nobody on the roster is really forcing the issue, so we’ll have to wait and see who will step up next to take on the Celtic Warrior, who has yet to defend the title since winning it more than two months ago
Other stuff to keep an eye on
- With Money in the Bank approaching in July, we’re going to need some qualifying matches in short order for the popular ladder matches. Maybe that’s why John Morrison actually won a singles match last week; he’s pretty much made for these ladder matches.
- Alexa Bliss is now an expert in hypnotizing people, and it helped her score a victory over Shayna Baszler at Hell in a Cell.
- Elias keeps getting counted out against terrible babyface Jaxson Ryker, so unfortunately this extremely boring feud must continue.
What will you be looking for on Raw tonight?


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Scanned copies of the signed legislation are available in the database records linked below:
AN ORDINANCE relating to the redevelopment of Yesler Terrace; authorizing the execution of Lot Boundary Adjustment #3016027; authorizing an exchange of property between the City of Seattle and the Housing Authority of the City of Seattle to complete the Lot Boundary Adjustment to allow for the dedication of the new South Washington Street as part of the final plat of Yesler Terrace Community; and finding, after a public hearing, that the exchange of property meets the requirements of Ordinance 118477, which adopted Initiative 42.
AN ORDINANCE relating to the Department of Neighborhoods; authorizing implementation of certain Neighborhood Matching Fund projects in 2014, and specifying that 2014 appropriations for the Neighborhood Matching Subfund shall carry forward automatically to future budget years; and ratifying and confirming certain prior acts.
AN ORDINANCE authorizing the Superintendent of the Department of Parks and Recreation to execute an amended and restated ground lease between the City of Seattle and the Center for Wooden Boats for development, operation and maintenance of an Education Center in Lake Union Park.
AN ORDINANCE appropriating money to pay certain audited claims and ordering the payment thereof.
A RESOLUTION relating to Seattle Public Utilities; adopting a 2015-2020 Strategic Business Plan for Seattle Public Utilities and endorsing a six-year rate path required to support the Strategic Business Plan.
A RESOLUTION prioritizing family unity and urging President Obama and Congress to replace the enforcement oriented federal immigration system with an immigration policy that keeps families together and respects the right of all workers to support their families.

domain: economics


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Hello! I'm happy to tell you that I am now selling a few items on ASOS marketplace. They are all vintage clothes that I have hand-selected and in some cases reworked.
My first item is reworked shorts which I have distressed, turned up and also sewn pretty floral fabric over the two back pockets as well as the front inside one. They're super cute and vintage looking and bang on trend at the moment- I'm tempted to keep them myself but not to worry I will resist! They're high-waisted and 1980/90's style :).
Remember they're one of a kind.
My next item is pretty exciting as it is a print by a spiritual/hippy style painter called Karmym, the painting is called 'the power of love' pretty cool huh? It looks really hipster/retro/hippie and it's totally unique.
This is a reworked New Look t-shirt which I turned into a crop top and turned up the sleeves. It's super cute right?! It's a size 14, I like it baggy but anyone size 14 and under can wear it! :) Again a totally unique item!
Click the image to check out my seller profile, or follow this link.
What do you think, should I put more on? Any requests?
Until next time,

domain: design


text:
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The answer, of course, is the same reason you pay to help protect my home from.
These situations tend to come up suddenly; fortunately, most insurance companies that offer 24-hour car insurance can provide you with an instant policy.
The Trump administration issued new insurance rules Wednesday morning to encourage more Americans to buy cheap, skimpy health plans originally.
Without 3 and 5 years 3rd party insurance, no new vehicles can hit the road.
If you are searching for temporary car insurance, you will probably come. may be able to help you print out your insurance card right away for immediate use.
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domain: finance


I would like to know the differences between RAM and Console RAM configuration for the Coldfire project, which .s19 file should be loaded to the target.
I am getting a build error in Console RAM but not with RAM configuration
You need to provide a lot more details.
What CPU? What hardware development system? What software development system (compiler)?
What do you mean by "Console RAM"? That doesn't mean anything to me.
If this is related to your next post then it would have been helpful to post those details to this thread rather than creating a new one.
Retrieving data ...


Real estate is an investment that creates wealth through equity and cash flow. It can also positively impact a neighborhood and enhance its social fabric. Revitalizing neighborhoods requires a process that values longtime residents’ visions of neighborhood change and avoids displacement.
Real estate investments can provide a solid return on investment. This is largely because property values generally appreciate over time, and government policy incentivizes homeownership through tax deductions and credits. Unlike other investment assets, real estate is relatively easy to finance with conventional mortgages or hard money loans from licensed lenders. Moreover, new business platforms are making it easier for consumers to become landlords and invest in multifamily and commercial properties without coming up with tens of thousands in cash upfront. As such, property ownership is one of the most accessible ways to build wealth.
Cash flow is the love child between a property’s income and expenses. It’s what is left over from rental revenue after typical operational expenditures and debt payments are made. Real estate investors like Steven Taylor Los Angeles are incentivized to maximize their properties’ cash flow. This can be achieved by increasing rent, decreasing expenses, or both. One common technique to increase property rents is performing a market analysis and adjusting monthly rent rates to align with local market trends. Adding non-rent revenue streams like coin-operated laundry or soda vending machines can also help improve cash flow. Tenant turnover is another factor that can reduce cash flow. Each time a tenant vacates the space, fixing and preparing the unit for new tenants takes money. Lastly, high property taxes can also negatively impact cash flow.
Many real estate investors, such as Steven Taylor LA, are integrating social value into their portfolios. This often involves focusing on the ‘S’ of ESG, or Sustainability, while providing a solid financial return for their investors. For example, investors may focus on community sustainability by building properties near public transportation hubs and service areas. This makes it easy for residents to get around without needing a car and reduces carbon emissions. Other types of social impact can include using local contractors for construction, ensuring that jobs are kept in the area, and supporting small businesses in the neighborhood. This enables the property to become an important philanthropic contributor in its surrounding community, helping to improve people’s lives. Impact measurement and management are key to any successful social impact strategy. This allows for better transparency, improved decision-making and greater accountability. It also ensures that an investment aligns with the investor’s values.
The allure of vibrant neighborhoods with trendy restaurants, cultural venues and green spaces attracts businesses that want to be a part of the revitalization. Redeveloping vacant neighborhoods can attract new residents and boost local economic activity. However, it’s important to consider how investment and redevelopment could lead to displacement. To help reduce the risk of gentrification and displacement, cities need to take proactive steps to support neighborhood stabilization. This includes creating a development process that allows community members to identify the housing and services they need, respects their vision of neighborhood change, and gives them power over decision-making.
Other measures include rent control, which protects tenants from sudden increases in their rent, establishes maintenance standards and limits security deposits, and promotes tenant organizing. NLIHC also advocates for longer affordability requirements in federal housing programs, making it easier to keep homes affordable for low-income residents.


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I have not posted a blog for two months now but I have been busy photographing and enjoying so many things that Mauritius has to offer. Here is a little selection of images to whet your appetite for the many blogs that will follow.
Everyday I find myself looking at the sky and the sea and appreciating the various shades of blue. Blue is the colour, of course. The mountains and sugar cane seem to be in almost every view of the island and look stunning illuminated by the Indian Ocean sunshine.
I drove to Grand Baie in the North for an early meeting; the sea is a very special of shade of blue there, almost metallic, it always surprises me.
The second photo was taken a few minutes later, having turned to the West.
This is a fishing area and the hull of the one behind was being worked on by five men, it had been damaged by coral.
The next morning I was up at dawn to go dolphin watching.
Early morning winter sunlight is not so spectacular on the West coast.
Many more boats started to appear with tourists eager to go swimming and snorkelling among the dolphins.
It was getting crowded and so we decided to head for home.
Returning to Black River an hour after sunrise, I was stunned by the blue of the sky, the green of the vegetation and the reflection of both in the lagoon.
There are so many things to do outdoors at the weekend in Mauritius but the first Tropica Dingue to be held on the island grabbed my attention. It was at Mon Tresor so I went along to see what it was all about.
But where is Mon Tresor? It is on the southernmost coastal plain of Mauritius, a natural landscape in the South East, close to the airport and earmarked for a sustainable urban development project. A combination of countryside and seaside against a backdrop of undulating sugar cane fields, the Christiane Vallet forest and century old trees near Mare aux Songes, where bones of the dodo have been found.
Tropica Dingue, or Tropical Madness as it translates, is a mix of trail running/walking/climbing with obstacles to get over, under or around, for teams in fancy dress who are prepared to accept the challenge against a backdrop of sun, palm trees, beach and a lagoon.
I headed for the excellent Holiday Inn, drove past and turned right towards the old Mon Tresor sugar factory. It was easy to find as most of the competitors had arrived early and were getting warmed up by the enthusiastic, cheerleading trio on stage.
Muscles were stretched and warmed as the competitors followed the keep fit/dance routines as jubilant and frenzied tunes pumped from the DJ tower overlooking coconut lawn as much as the adrenaline.
The starts were staggered as this was all about participation and not a race. The sun came out just as the first teams left the start.
First, the tyre obstacle challenge.
There were some fantastic costumes ranging from Superheroes to Neon Pink keep fit outfits.
The promised backdrop of sugar cane fields was truly stunning, the cane flowers blowing in the breeze coming from the sea.
The coastline was looking particularly blue with frothy, snow white surf soaking the black rocks on the shoreline. Perfect for a bit of fishing.
What a beautiful sandy beach to walk along, just as nature intended it.
The sand was warm and soft as competitors scrambled under the nets no doubt tempted by the sea lapping at the shore.
Plenty of photo-opportunities for Enrico, the official photographer.
…and he took lots!
For some the sea was just too tempting and the opportunity to cool off for a bit and enjoy the view.
Having had a drinks break, there was a nice walk/run before a big challenge loomed up ahead. Most stopped running when they saw it!
You had to pull yourself up and over, sliding down the other side. For some this was easy but for the more gravitationally challenged, they needed a lot of assistance, slings or a JCB.
Gloves, dry trainers and a hefty shove definitely helped.
A fantastic team of volunteers assisted on all the obstacles and could not do enough to make the day enjoyable for all the competitors.
Not wishing to pull the obstacle over, some chose to walk around it. Wise.
Dragging a tyre by a rope along the dusty ground around an obstacle took some determination.
The final obstacle was a water slide, not for those scared of heights or muddy water.
The end now in sight, competitors pulled themselves out of the pool and headed for the finish.
Clutching a few sugar cane flowers, another team finishes the First Mauritius Tropica Dingue, happy have discovered where Mon Tresor is, enjoyed a fun couple of hours and looking forward to some dry, clean clothes and lunch!
Many congratulations to the organisers (especially Marvellous Melanie de L’Estrac), all the sponsors and the team from La Reunion who put on the event. It certainly showed that the 1,400 Mauritians who took part not only have a great sense of humour but also tremendous spirit as they wholeheartedly threw themselves, literally, into Tropica Dingue.
I would like to sign up for next year before it is sold out.
There are many challenges in moving to a new country, some you have no choice to face, others can be tremendous fun as I found out when I recently learnt how to dive. After all, crystal clear, turquoise lagoons, a coral reef that almost entirely circles the island and a sea temperature rarely below 25 degrees is quite appealing. So I signed up for the open water diver course and I discovered and experienced that Mauritius is a brilliant place to learn how to dive!
Having parted with some rupees and filled in a few forms, signing away any personal liability, you get one of these manuals with instructions to read and remember Section One (77 pages) and answer all the test questions at the end of each sub-section. The manual was a combination of physics, biology, fashion and plumbing.
The first lesson was in the pool at a nearby luxury hotel but I had to get kitted up first.
You need a snug fit as the water seeps below the surface of the neoprene shortie wet suit and keeps you warm. Now the mask.
I had always had problems with leaking when diving before (from the face mask). The advice was that it should just stick on your face if you just put it there. I found one that did and did not have to strap it on as tight as I had put masks on before. Good tip!
Size 43 blue fins now checked for size, time for that jacket thing. Good tip number 2, peel the heel of the fin back down, it is so much easier to put on.
The jacket, or BCD as they call it, was surprisingly comfortable. This is great, I thought, it will be easy to swim like this underwater. I had forgotten the most important part, the cylinder, the regulator (breathing system) and weight belt.
The golf ball is to make me stand out from the other qualified divers. That actually was not too difficult!
And finally, the weight belt to counteract ‘positive buoyancy’!
I set off for the first dive in the luxury swimming pool to learn how to breathe and move underwater, get used to the equipment and manage some safety procedures in case of emergency. Walking the 100 metres to the pool, bent almost double with the weight of the cylinder and equipment was fun and I heard a few giggles from the tourists relaxing on their sun beds.
So, at last, into the pool and my first experience of scuba diving. Wonderful! Cleaning your mask underwater was a vital skill to learn. This involved letting some water in the mask, tilting your head backwards and breathing out through your nose being careful with my contact lenses. I repeated this manoeuvre several times as the two young bikini clad ladies swimming above me were totally unaware of the view they were affording me!
The next lesson was in the sea and really good fun where I felt the feeling of being almost weightless underwater, saw lots of colourful fish and coral and practised more emergency measures like running out of air and complete removal of my mask.
The third lesson had to be aborted at there was a terrific and persistent rainstorm. This is a tropical country and when it rains, it rains but it is not cold.
Despite being ready and it not mattering that it was wet in the sea already, conditions were just too rough, too windy.
Now some Mathematics to learn and to understand my ABT from my TBT!
..and finally, after the training, the theory, 244 pages of the manual, the dives and the exam, you finally get one of these! I am proud!
Thank you to everyone at EasyDive, Le Morne, especially the extremely patient Guillame, (..”Now this is very important..”) who helped me get this far.
I have signed up for the advanced course and underwater shots are promised for a future post!
After a few hectic weeks of packing, clearing, goodbyes and mild panic, Mauritian immigration greeted me warmly on my arrival at Plaisance airport. I am finally here, I thought. During my first few days on the island it has been a pleasure to meet so many friendly people who could not have done more to make me feel so welcome.
I have only had one real challenge so far that vexed me a little! I brought two suitcases with me and having opened the first at my temporary address (I move to Tamarin on the West Coast in December) I tried to open the second. The combination lock had jammed! Rather than resort to brute force I decided to leave it for the moment and manage with the clothes I had. I tried again a few days later and voila it opened as if by magic.
The weather has been splendid, the food delicious and the views amazing. You know you are in Mauritius when you see a view like I did in the wing mirror of my car on the first day I drove it from the dealer’s showroom.
Caudan waterfront was not too busy when I went for a walk and a cool drink in the afternoon. The shops were diverse and interesting and one walkway showed that umbrellas are not just there to keep the rain off! I am also looking forward to the freshly prepared vegetarian wraps at the Kauai restaurant.
I have had walks on the beach in Grand Baie, Pereybere, La Preneuse and Belle Mare and obviously had to enjoy the sea; is the water really 25 degrees all year around?
I managed to have an hour’s snorkelling in Blue Bay where I was amazed to see so many colourful fish so close to the beach.
This is a wonderful island with so much to explore, discover and enjoy.


A 13-person Stannah passenger lift has been installed at the Tormead School for girls in Guildford, Surrey. Its adjacent-entry doors allow for the easy movement of people and equipment across the school’s four floors.
The Stannah Xtralift has been fitted within the school’s new four-storey atrium. The passenger lift was specified due to its adjacent-entry doors which could easily handle the demanding workload and large loads of equipment.
The lift also meets all the required standards for schools including the Equality Act 2010, Part M and EN81-70, EN81-1, CE mark and The Lift Directive 95/16/EC.
The Xtralift’s car and landing doors are finished in satin stainless steel complemented by a grey, easy-clean laminated interior; half-height rear-wall mirror; and an anti-bacterial grey floor.
The wall-mounted lift features an energy efficient, fearless traction drive and travels a distance of 8750mm at a speed of 1.0m/s.
The lift is covered by Stannah’s comprehensive service plan which includes 24-hour breakdown and service visits, with continued lift maintenance by the Southern England branch of Stannah Lift Services.
Phone: 01264 343777
Fax: 01264 337942
A five-year partnership between industry and academia has resulted in a ground-breaking diagnostic tool, the Building Moisture Index from the Property Care Association (PCA).Posted in Articles, Building Associations & Institutes, Building Industry News, Building Products & Structures, Building Services, Damp & Waterproofing, Facility Management & Building Services, Health & Safety, Innovations & New Products, Video of the Week
Clyde Radiators, specialist in bespoke heating solutions, has relaunched its website to make it simpler than ever for customers to obtain quotes and specifications for any residential or commercial project.Posted in Articles, Building Industry News, Building Services, Heating Systems, Controls and Management, Heating, Ventilation and Air Conditioning - HVAC, Information Technology, Innovations & New Products, Plumbing, Posts
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Happy Shakespeare Day!
People around the globe are celebrating all that is brilliant about the bard as the 23rd April marks the 400th anniversary of Shakespeare’s death.
Shakespeare wrote plays and poetry that are enormously rewarding to read, act and watch, and they are great for reading with children. Sometimes his works are seen as inaccessible or elitist, but the fact that they are still loved more than 400 years later is testament to the subtle richness of his language, universality of his plot devices, and relatability of his characters. There is something in Shakespeare for everyone, and whatever your children find will be sure to touch them forever.
Are your children struggling to take an interest in Shakespeare? Take a look at our favourite books below to help them nurture a love of the lyric.
Mini – 0-7 years
by Jane Bingham
What would it be like to grow up in Tudor England? What would everyday life be like? What if you just happened to be a gifted young playwright called Shakespeare? This book lets you find out – not just by reading but by doing things and making stuff. (Learning ought to be fun, right?) Learn about Shakespeare’s family life, his world-famous plays and the busy theatres of Tudor London. You’ll read about a boy actor’s life, and even get to make your own model theatre!
XD – 7-11 years
Shakespeare Stories Box Set
by William Shakespeare and Tony Ross
A box of the Bard. The funniest retellings: so much crazy drama that Tony Ross did pictures all the way through. Expect all the intrigue, humour and excitement of the original plays. In brand new funny stories full of gags and cheeky artwork. (You can see that Tony Ross had heaps of fun drawing Shakey’s famous characters.) All supplied in a handsome box set to dress up your bookshelf. What’s not to like?
Horribly Famous: William Shakespeare and his Dramatic Acts
by Andrew Donkin and Clive Goddard
A Horrible look at the brilliant Bard, with chuckles on every page. You’ve probably heard of William Shakespeare. He is dead famous for: writing a few plays, having a bit of a way with words, and creating characters like romantic Romeo and murderous Macbeth. But did you know that our Will did a seven-year vanishing act, nearly had his head chopped off by the Queen, and nicked an entire theatre? Yes – even though he’s dead, Shakey’s still full of drama!
Teen – 11+
Tales from Shakespeare
by Mary Lamb and Charles Lamb
Alas! Poor Shakespeare! If you don’t know him well, grab this quick chance to fix that glaring hole in your cultural education. Twenty of Shakespeare’s classic plays retold in brilliant short stories. Or to put it another way, around 60 hours of theatre time in one shortish book. All the drama. No numb bum. All the favourites are in here: Hamlet, The Tempest, Macbeth, Romeo and Juliet. All the crucial points you need to remember for your English essays are here too. What we like best of all is that, though they’re short and simple, these stories keep the feel and power of the real thing. That’s why they’re classics in their own right.
Oxford Illustrated Shakespeare Dictionary
‘There is no darkness but ignorance’, says the Bard. So find out what all his tricky words and quotes mean! We love Shakey. But we have to admit, he takes a bit of decoding. Want to enjoy his verses more and scratch your head a bit less? Look no further. From A to Z, here are the words and meanings you need to know to make sense of him. All with example phrases from his most famous plays. Plus colour pictures and feature sections on stuff like stage directions, clothes, armour, music and olde-worlde swearing. Tee hee. ‘Knowledge is the wing wherewith we fly to heaven’. And pass our English exams.


Knife wielding man holds hostages at job centre in northeast England
London [U.K.] June 9 (ANI): An armed man is holding hostages at a job centre in Northeast England.
Police acted swiftly by cordoning off the area around the job centre. They said that several staff members are among the hostages.
Police said that they have opened up negotiations with the assailant and added that they are treating this as an isolated incident at this stage. (ANI)


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7. Watch Dogs 2
While it’s likely that many gamers did not expect much from Ubisoft’s Watch Dogs 2, the truth is that the game has turned out to be one of the best GTA clones we have seen in years. Because not only did Ubisoft’s game feature a more interesting protagonist in hacker Marcus Holloway, but its San Francisco setting was a colourful playground for players to unleash all sorts of mayhem.
The game also had a more light-hearted tone than is usually found in games of this ilk, while players were able to hack everything from mobile phones to cars while attempting to take down an evil corporation run by a control-obsessed megalomaniac. All in all, Watch Dogs 2 delivered some of the best open-world gameplay since GTA V this year, and was one of 2016’s best releases no doubt.


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Shout out to the homie Torae for coming through to The Jam last night and killin' it. On June 2nd, Tor and Marco Polo will be releasing their new album, Double Barrel, via Duck Down records. If you're looking for some raw ass lyricism mixed with some head nodding beats, look no further. Today they leaked the latest single from the album, "Hold Up" featuring Sean Price and Masta Ace. This joint is definitely that real NY hip-hop, what more could you ask for?
Torae "Hold Up (prod. Marco Polo)" feat. Sean Price & Masta Ace


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CDK6 is an essential direct target of NUP98 fusion proteins in acute myeloid leukemia.
ABSTRACT: Fusion proteins involving Nucleoporin 98 (NUP98) are recurrently found in acute myeloid leukemia (AML) and are associated with poor prognosis. Lack of mechanistic insight into NUP98-fusion-dependent oncogenic transformation has so far precluded the development of rational targeted therapies. We reasoned that different NUP98-fusion proteins deregulate a common set of transcriptional targets that might be exploitable for therapy. To decipher transcriptional programs controlled by diverse NUP98-fusion proteins, we developed mouse models for regulatable expression of NUP98/NSD1, NUP98/JARID1A, and NUP98/DDX10. By integrating chromatin occupancy profiles of NUP98-fusion proteins with transcriptome profiling upon acute fusion protein inactivation in vivo, we defined the core set of direct transcriptional targets of NUP98-fusion proteins. Among those, CDK6 was highly expressed in murine and human AML samples. Loss of CDK6 severely attenuated NUP98-fusion-driven leukemogenesis, and NUP98-fusion AML was sensitive to pharmacologic CDK6 inhibition in vitro and in vivo. These findings identify CDK6 as a conserved, critical direct target of NUP98-fusion proteins, proposing CDK4/CDK6 inhibitors as a new rational treatment option for AML patients with NUP98-fusions.
Project description:NUP98 gene rearrangements occur in acute myeloid leukemia and result in the expression of fusion proteins. One of the most frequent is NUP98-DDX10 that fuses a portion of NUP98 to a portion of DDX10, a putative DEAD-box RNA helicase. Here, we show that NUP98-DDX10 dramatically increases proliferation and self-renewal of primary human CD34+ cells, and disrupts their erythroid and myeloid differentiation. It localizes to their nuclei and extensively deregulates gene expression. Comparison to another leukemogenic NUP98 fusion, NUP98-HOXA9, reveals a number of genes deregulated by both oncoproteins, including HOX genes, COX-2, MYCN, ANGPT1, REN, HEY1, SOX4 and others. These genes may account for the similar leukemogenic properties of NUP98 fusion oncogenes. The YIHRAGRTAR sequence in the DDX10 portion of NUP98-DDX10 represents a major motif shared by DEAD-box RNA helicases that is required for ATP binding, RNA-binding and helicase functions. Mutating this motif diminished the in vitro transforming ability of NUP98-DDX10, indicating that it has a role in leukemogenesis. These data show for the first time the in vitro transforming ability of NUP98-DDX10 and show that it is partially dependent on one of the consensus helicase motifs of DDX10. They also point to common pathways that may underlie leukemogenesis by different NUP98 fusions.
Project description:NUP98 is a nucleoporin that plays complex roles in the nucleocytoplasmic trafficking of macromolecules. Rearrangements of the NUP98 gene in human leukemia result in the expression of numerous fusion oncoproteins whose effect on nucleocytoplasmic trafficking is poorly understood. The present study was undertaken to determine the effects of leukemogenic NUP98 fusion proteins on CRM1-mediated nuclear export. NUP98-HOXA9, a prototypic NUP98 fusion, inhibited the nuclear export of two known CRM1 substrates: mutated cytoplasmic nucleophosmin and HIV-1 Rev. In vitro binding assays revealed that NUP98-HOXA9 binds CRM1 through the FG repeat motif in a Ran-GTP-dependent manner similar to but stronger than the interaction between CRM1 and its export substrates. Two NUP98 fusions, NUP98-HOXA9 and NUP98-DDX10, whose fusion partners are structurally and functionally unrelated, interacted with endogenous CRM1 in myeloid cells as shown by co-immunoprecipitation. These leukemogenic NUP98 fusion proteins interacted with CRM1, Ran, and the nucleoporin NUP214 in a manner fundamentally different from that of wild-type NUP98. NUP98-HOXA9 and NUP98-DDX10 formed characteristic aggregates within the nuclei of a myeloid cell line and primary human CD34+ cells and caused aberrant localization of CRM1 to these aggregates. These NUP98 fusions caused nuclear accumulation of two transcription factors, NFAT and NFkappaB, that are regulated by CRM1-mediated export. The nuclear entrapment of NFAT and NFkappaB correlated with enhanced transcription from promoters responsive to these transcription factors. Taken together, the results suggest a new mechanism by which NUP98 fusions dysregulate transcription and cause leukemia, namely, inhibition of CRM1-mediated nuclear export with aberrant nuclear retention of transcriptional regulators.
Project description:In this report, we show that expression of a NUP98-PHF23 (NP23) fusion, associated with acute myeloid leukemia (AML) in humans, leads to myeloid, erythroid, T-cell, and B-cell leukemia in mice. The leukemic and preleukemic tissues display a stem cell-like expression signature, including Hoxa, Hoxb, and Meis1 genes. The PHF23 plant homeodomain (PHD) motif is known to bind to H3K4me3 residues, and chromatin immunoprecipitation experiments demonstrated that the NP23 protein binds to chromatin at a specific subset of H3K4me3 sites, including at Hoxa, Hoxb, and Meis1. Treatment of NP23 cells with disulfiram, which inhibits the binding of PHD motifs to H3K4me3, rapidly and selectively killed NP23-expressing myeloblasts; cell death was preceded by decreased expression of Hoxa, Hoxb, and Meis1. Furthermore, AML driven by a related fusion gene, NUP98-JARID1A (NJL), was also sensitive to disulfiram. Thus, the NP23 mouse provides a platform to evaluate compounds that disrupt binding of oncogenic PHD proteins to H3K4me3.
Project description:Structural chromosomal rearrangements of the Nucleoporin 98 gene (NUP98), primarily balanced translocations and inversions, are associated with a wide array of hematopoietic malignancies. NUP98 is known to be fused to at least 28 different partner genes in patients with hematopoietic malignancies, including acute myeloid leukemia, chronic myeloid leukemia in blast crisis, myelodysplastic syndrome, acute lymphoblastic leukemia, and bilineage/biphenotypic leukemia. NUP98 gene fusions typically encode a fusion protein that retains the amino terminus of NUP98; in this context, it is important to note that several recent studies have demonstrated that the amino-terminal portion of NUP98 exhibits transcription activation potential. Approximately half of the NUP98 fusion partners encode homeodomain proteins, and at least 5 NUP98 fusions involve known histone-modifying genes. Several of the NUP98 fusions, including NUP98-homeobox (HOX)A9, NUP98-HOXD13, and NUP98-JARID1A, have been used to generate animal models of both lymphoid and myeloid malignancy; these models typically up-regulate HOXA cluster genes, including HOXA5, HOXA7, HOXA9, and HOXA10. In addition, several of the NUP98 fusion proteins have been shown to inhibit differentiation of hematopoietic precursors and to increase self-renewal of hematopoietic stem or progenitor cells, providing a potential mechanism for malignant transformation.
Project description:Chromosomal translocations involving the nucleoporin NUP98 have been described in several hematopoietic malignancies, in particular acute myeloid leukemia (AML). In the resulting chimeric proteins, Nup98's N-terminal region is fused to the C-terminal region of about 30 different partners, including homeodomain (HD) transcription factors. While transcriptional targets of distinct Nup98 chimeras related to immortalization are relatively well described, little is known about other potential cellular effects of these fusion proteins. By comparing the sub-nuclear localization of a large number of Nup98 fusions with HD and non-HD partners throughout the cell cycle we found that while all Nup98 chimeras were nuclear during interphase, only Nup98-HD fusion proteins exhibited a characteristic speckled appearance. During mitosis, only Nup98-HD fusions were concentrated on chromosomes. Despite the difference in localization, all tested Nup98 chimera provoked morphological alterations in the nuclear envelope (NE), in particular affecting the nuclear lamina and the lamina-associated polypeptide 2? (LAP2?). Importantly, such aberrations were not only observed in transiently transfected HeLa cells but also in mouse bone marrow cells immortalized by Nup98 fusions and in cells derived from leukemia patients harboring Nup98 fusions. Our findings unravel Nup98 fusion-associated NE alterations that may contribute to leukemogenesis.
Project description:Recent studies have shown that a subset of nucleoporins (Nups) can detach from the nuclear pore complex and move into the nuclear interior to regulate transcription. One such dynamic Nup, called Nup98, has been implicated in gene activation in healthy cells and has been shown to drive leukemogenesis when mutated in patients with acute myeloid leukemia (AML). Here we show that in hematopoietic cells, Nup98 binds predominantly to transcription start sites to recruit the Wdr82-Set1A/COMPASS (complex of proteins associated with Set1) complex, which is required for deposition of the histone 3 Lys4 trimethyl (H3K4me3)-activating mark. Depletion of Nup98 or Wdr82 abolishes Set1A recruitment to chromatin and subsequently ablates H3K4me3 at adjacent promoters. Furthermore, expression of a Nup98 fusion protein implicated in aggressive AML causes mislocalization of H3K4me3 at abnormal regions and up-regulation of associated genes. Our findings establish a function of Nup98 in hematopoietic gene activation and provide mechanistic insight into which Nup98 leukemic fusion proteins promote AML.
Project description:NUP98-NSD1-positive acute myeloid leukemia (AML) is a poor prognostic subgroup that is frequently diagnosed in pediatric cytogenetically normal AML. NUP98-NSD1-positive AML often carries additional mutations in genes including FLT3, NRAS, WT1, and MYC. The purpose of our study was to characterize the cooperative potential of the fusion and its associated Neuroblastoma rat sarcoma (NRAS) mutation. By constitutively expressing NUP98-NSD1 and NRASG12D in a syngeneic mouse model and using a patient-derived xenograft (PDX) model from a NUP98-NSD1-positive AML patient, we evaluated the functional role of these genes and tested a novel siRNA formulation that inhibits the oncogenic driver NUP98-NSD1. NUP98-NSD1 transformed murine bone marrow (BM) cells in vitro and induced AML in vivo. While NRASG12D expression was insufficient to transform cells alone, co-expression of NUP98-NSD1 and NRASG12D enhanced the leukemogenicity of NUP98-NSD1. We developed a NUP98-NSD1-targeting siRNA/lipid nanoparticle formulation that significantly prolonged the survival of the PDX mice. Our study demonstrates that mutated NRAS cooperates with NUP98-NSD1 and shows that direct targeting of the fusion can be exploited as a novel treatment strategy in NUP98-NSD1-positive AML patients.
Project description:BACKGROUND:The NUP98 gene is involved in multiple rearrangements in haematological malignancy. The leukemic cells in an acute myeloid leukemia (AML) patient with a t(9;11)(p22;p15) were recently shown to have a fusion between the NUP98 gene and the LEDGF gene but it was not demonstrated that this fusion was recurrent in other leukaemia patients with the same translocation. RESULTS:We used RT-PCR to analyse the leukemic cells from an AML patient who presented with a cytogenetically identical translocation as the sole chromosomal abnormality. A NUP98-LEDGF fusion transcript was observed and confirmed by sequencing. The reciprocal transcript was also observed. The fusion transcript was not detectable during remission and recurred at relapse. The breakpoints in the NUP98 and LEDGF genes were different to those previously reported. The NUP98 breakpoint occurs in the intron between exons 8 and 9. It is the most 5' breakpoint reported in a translocation involving the NUP98 gene. All of the LEDGF gene is included in the fusion except for exon 1 which codes for the first 24 amino terminal amino acids. CONCLUSIONS:Our results show that fusion of the NUP98 and LEDGF genes is a new recurrent translocation in AML.
Project description:We assessed lineage involvement by NUP98 translocations in myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and T-cell acute lymphoblastic leukemia (T-ALL). Single cell analysis by FICTION (Fluorescence Immunophenotype and Interphase Cytogenetics as a Tool for Investigation of Neoplasms) showed that NUP98-translocations with various partners, i.e. NSD1, DDX10, RAP1GDS1, and LNP1, always affected a CD34+/CD133+ hematopoietic precursor. Interestingly, in MDS/AML myelomonocytes, erythroid cells, B- and T- lymphocytes belonged to the abnormal clone, while in T-ALL only CD7+/CD3+ cells were involved. The partner did not appear to play a major role in determining the leukemia phenotype as shown in AML and T-ALL with the same NUP98-RAP1GDS1 fusion. Additional hits, namely mutations of FLT3 and CEBPA in MDS/AML and mutation of NOTCH1 plus MYB duplication in T-ALL, were identified in leukemias with, respectively, myeloid or T-lymphoid phenotype. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from cryopreserved diagnostic bone marrow or peripheral blood samples. Copy number and Copy neutral LOH analysis of with Affymetrix Cytogenetic 2.7 and Cytoscan HD SNP arrays was performed on 6 NUP98 rearranged leukemias.
Project description:BACKGROUND: NUP98 gene rearrangements have been reported in acute myeloid leukemia, giving rise to fusion proteins that seem to function as aberrant transcription factors, and are thought to be associated with poor prognosis. FINDINGS: A patient with treatment-related acute myeloid leukemia presented a t(3;11)(p11;p15) as the only cytogenetic abnormality. FISH and molecular genetic analyses identified a class 1 homeobox gene, POU1F1, located on chromosome 3p11, as the fusion partner of NUP98. In addition, we have found that the patient harbored an FLT3-ITD mutation, which most likely collaborated with the NUP98-POU1F1 fusion gene in malignant transformation. CONCLUSIONS: We have identified POU1F1 as the NUP98 fusion partner in therapy-related AML with a t(3;11)(p11;p15). This is the first POU family member identified as a fusion partner in human cancer.


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June 16, 2022
Songqiao “Shawn” Wei, an Endowed Assistant Professor of Geological Sciences in the Department of Earth and Environmental Sciences in the College of Natural Science at Michigan State University, has been studying the earthquakes in response to Earth’s tectonic plate movement around the world. In this "Ask the Expert" column, he explains earthquakes, how they are detected and his current research related to them.
August 16, 2021
MSU seismologist Songqiao “Shawn” Wei is the recipient of a $501,597 National Science Foundation Early CAREER Award to conduct a series of seismic attenuation studies on regional and global scales. These systematic investigations will potentially advance our understanding of seismic interpretation, upper-mantle dynamics, and material recycling in the Earth’s interior.


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domain: chemistry


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April 2 is National Peanut Butter and Jelly Day
Here are today’s five thing to know about Peanut Butter and Jelly:
- Studies show that there is a 75% chance that if you drop a slice of peanut buttered bread, it will fall face down.
- 50 percent of all the peanuts grown around the world are used to make peanut butter.
- It is estimated that the average American school child will have munched through 1500 Peanut Butter and Jelly sandwiches before graduation.
- An 18 ounce jar of peanut butter will contain about 850 peanuts.
- The largest recorded peanut butter and jelly sandwich in the world was lovingly crafted in Peanut, Pennsylvania in 1993. It was 40 ft long and contained 150lbs of peanut butter and 50lbs of jelly.
By law, any product labeled “peanut butter” in the United States must be at least 90 percent peanuts.
Peanut butter was first introduced to the USA in 1904 at the Universal Exposition in St. Louis by C.H. Sumner, who sold $705.11 of the “new treat” at his concession stand.
A 2002 survey showed the average American will have eaten 2,500 of these sandwiches before graduating from high school.
Today’s Pinterest Board : Foodimentary
Today’s Food History
- 742 Charlemagne was born. Charlemagne, Charles I, Charles the Great, King of the Franks, Charles le Grand, Carolus Magnus, Karl Der Grosse, King of the Lombards, master of Western Europe, Emperor. Some of the food related ‘facts’ I have come across related to Charlemagne:
* the peacock was first served in Europe during his reign;
* Sauerbraten was invented by Charlemagne;
* Roquefort cheese was a favorite of his;
* the knife began to be used to eat food for the first time during his reign (rather than the fingers);
* Roses were used to cover tables for meals.
I have no real corroboration for any of these ‘facts’ think ‘truthy’
- 1819 The periodical, ‘American Farmer’ was founded by John Skinner
- 1827 Joseph Dixon began manufacturing the first lead (graphite) pencils. Necessary to write recipes and menus
- 1840 Emile Zola was born. French writer and critic who was also known as a gourmand. His detailed descriptions of simple meals, banquets and eating in his novels are among the best to be found anywhere. He was also known for his own luxury dinner parties. “What will be the death of me are bouillabaisses, food spiced with pimiento, shellfish, and a load of exquisite rubbish which I eat in disproportionate quantities.”
- 1863 THE RICHMOND BREAD RIOTS – Shortages of food caused hundreds of angry women gathered in Richmond, Virginia to march on the governor’s office and then on the government commissary to demand bread. It ended in a riot when they broke into the commissary and then other shops & buildings and carried out anything they could carry. Even the hospital reported losing over 300 pounds of beef. Arrests were made, but at the request of authorities, the newspapers downplayed the incident, and records were later destroyed when the Confederate government fled and burned much of the town behind them.

domain: food


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San Diego County-Wide Bootcamp Resources
Welcome to your GEDC Bootcamp Resource page! Check back after your Bootcamp for meeting recordings, chat notes, slides and more.
Your Bootcamp details:
Thursday, July 23
July 23, 2020 Bootcamp
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Your GEDC Bootcamp Resources
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Your Bootcamp Faculty
Dr. Don Melady is an emergency physician at Mount Sinai Hospital in Toronto, Canada and a founding member of the Geriatric Emergency Department Collaborative. He is the author of the website www.geri-EM.com – a CME accredited program for geriatric emergency medicine education – and the chair of the Geriatric EM committee of the International Federation of Emergency Medicine.
Dr. Kevin Biese serves as an Associate Professor of Emergency Medicine (EM) and Internal Medicine, Vice-Chair of Academic Affairs, and Co-Director of the Division of Geriatrics Emergency Medicine at the University of North Carolina (UNC) at Chapel Hill School of Medicine as well as a consultant with West Health. With the support of the John A. Hartford and West Health Foundations, and alongside Dr. Ula Hwang, he serves as Co-PI of the national Geriatric Emergency Department Collaborative. He is grateful to chair the first Board of Governors for the ACEP Geriatric Emergency Department Accreditation Program. His passion is for improved education and systems of care for older adults, and he has published multiple materials in both these areas.
Dr. Ula Hwang is the Medical Director for Geriatric Emergency Medicine at New York University and a core investigator at the GRECC (Geriatrics Research, Education and Clinical Center) at the James J. Peters Bronx VAMC. Her research focuses on improving the quality of care older adults receive in the ED setting that ranges from observational studies of analgesic safety and effectiveness in older patients to multi-center implementation science studies of geriatric emergency care interventions. Hwang currently co-PIs the Geriatric Emergency Department Collaborative and is the PI on the Geriatric Emergency care Applied Research (GEAR) network.
Dr. Adam Perry is a community emergency physician and fellowship-trained geriatrician. Current positions include faculty with The Geriatric Emergency Department Collaborative; reviewer with ACEP’s Geriatric Emergency Department Accreditation program; educational consultant; and independently-contracted emergency physician with Commonwealth Health System in Northeastern Pennsylvania. He has worked emergency departments ranging from rural “critical access” to urban trauma centres; as well as in Post-Acute and Long-Term Care, and house call medicine.
Aaron Malsch is the Senior Services Program Manager at AdvocateAuroraHealth (AAH) in Wisconsin & Illinois. He supports several geriatric models of care (NICHE, Geri ED, HELP, ACE Tracker, Geriatric Scholars). His focus is on nursing and interprofessional practice as it relates to the elder population throughout the AAH system of clinics, hospitals, emergency departments, home care services, and long term setting partners. In support of these models of care, Aaron has developed expertise in developing EHR workflow tools and reports to facilitate front line staff’s efforts and demonstrate outcomes. He leads the Geriatric ED implementation and achieved ACEP Geri ED accreditation at all AAH EDs. Aaron contributes nationally to the improvement of care for older adults, highlighted by being Chair of the geriatric committee at the Emergency Nurses Association (ENA), co-planner of GEDC symposium at the ENA conference, and reviewer of Geriatric ED Accreditation program at ACEP.