text:
Spirits are high leading into the penultimate episode of I May Destroy You. “Would You Like to Know the Sex?” opens with a burst of energy, with Kwame leading his fitness class through a rigorous exercise. When he pauses the workout for a water break, Kwame goes back to check his phone, leaving a Grindr message left unreturned. Arabella goes back to her latest book, and Terry also checks her phone. She begins to break down in tears, and her friends rush to her side. Fortunately, the news is good: a new job! The trio embraces and celebrates her joy.
At Arabella’s place, Kwame and Terry talk with Ben, who’s busily repotting some herbs for his garden. Kwame asks if this new date is making him nice, which he doesn’t see himself. Terry insists they’re all nice, and sneaks back in to get Arabella, who was last seen obsessively reading her book on the toilet. Once outside, Arabella finishes her book and says she must meet its author, who’s practically her doppelgänger on paper, with the same publisher and a sound-alike name. But she can’t ask her publisher Susy for an introduction — that would prompt awkward questions about how her book is going. Instead, she tries making an earnest video asking to meet the author, Della, but then goes for a more daring approach, filming herself as if she couldn’t put the book down even for a bathroom break. She sends the video and contact information to Della’s messages, but sadly they’re left unread, and then Della blocks her altogether.
This sends Arabella to Susy’s plant-lined office, where as Arabella feared, she asks about the book’s progress. She asks to meet Della for advice, and Susy denies her, curtly ending the visit. When Arabella stops by her agents, she finds out that Susy has dropped her and is asking to be repaid the advance Arabella has already spent, which prompts her agents to also dump her. Arabella retreats to Terry’s side at a café, where Terry slips her cute waiter her number. Della finally responds and offers to meet Arabella, breaking her crying spell, and as Terry dashes off to an impromptu date with their waiter, Arabella stays at the café waiting to meet her literary hero.
Kwame meets Nilufer again for a daytime chat to try and smooth things over. He apologizes profusely, but her anger remains, and she even goes so far to call him a criminal for deceiving her. After a short time, she angrily declares him canceled and storms off. Over on Terry’s date, things seem to be going pretty well until their server gushes over her date, as if he were famous. She excuses herself for the bathroom and looks up her date, Kai (Tyler Luke Cunningham), on her phone and finds out that he’s a trans musician. She returns to the table tense, and Kai offers to get the bill since she seems uncomfortable. Terry says that she’s okay, and the pair keep talking. He’s upfront about the fact that he’s trans just as Terry’s food arrives. She says, “If I leave, people will think I’m transphobic.” Kai asks, “And you’re not transphobic?” She stays, insisting she’s not, and cuts into her meal. He teases her that she’s a prude. “I’m not a prude,” Terry says with a smile. “I’ve had a threesome.” They talk about the experience more, and Kai senses something’s off. He figures out that the two men Terry hooked up with might have not been strangers she met at a club, but two men who had plans to deceive someone for sex. She looks hurt and goes quiet, and Kai acknowledges her pain.
Still at the café waiting on Della, Arabella sees Zain and he catches up with her. She lies, saying she’s living her best life. She grimaces, trying to avoid his look, but he stays and then it dawns on her: He’s Della. He explains that Susy picked the name so she could still publish his book and that he was supposed to help her the first time and didn’t, so when Arabella sent him the video asking for help, he decided to try to make things right.
Zain gets to work laying out what Arabella needs to do to finish her story. Arabella invites him back to her place — not like last time when they hooked up, but to work. She begins laying out cards for her story and handing them to him to tack up on her wall. Her work is finally taking shape. Some time later, the note cards fill her wall, as new ones start to join them. There’s another noticeable difference in her work, too. “I thought you were writing about consent,” Zain comments, to which Arabella answers, “So did I.” He admits he doesn’t understand it, but she thanks him anyway. On his way out, she asks him to throw out the trash she hasn’t been able to take out herself. She thanks him again, this time as Della.
Now alone with her work, Arabella begins to rearrange the cards on the walls, bringing up flashes of past memories in Italy and as recent as Halloween. The work continues into the daylight hours and for many days later, as the scene becomes a montage of Arabella furiously working, staring intently at her walls of cards and eating bowls of cereal. She emerges from her room ready for another bar watch and invites her roommate to come with her. He declines, staying instead with his garden and watching a video on loneliness.
Kwame is enjoying a happier time with kindhearted date Tyrone (Gershwyn Eustache Jr.) at a museum exhibit. Even Nilufer’s angry text messages can’t bother him as they both look at large photographs of Black men kissing and holding onto each other. There’s two parallel stories of forgiveness in this episode, Kwame and Arabella’s, each following different trajectories. Kwame tries to apologize to the woman he lied to, but she rejects it and remains angry. Zain comes back into Arabella’s life in an unusual way and tries to make amends for what he did. She accepts, and the result is a renewed creative life for her. The series doesn’t judge Nilufer’s anger, but it follows Arabella’s growth as it offers the most possibility for change.
Back at Ego Death, Arabella watches everyone intensely. Just after a smiling Terry joins her friend after her successful date, Arabella recognizes a face in the crowd next to her rapist. She flashes back through the memories she thought had been lost, all the details of that terrible night she couldn’t remember. Arabella stares directly at the screen as she’s looking through the bar window at the two men responsible for her sexual assault. Then the episode cuts to black. Arabella may be learning to forgive, but how will that play out now that she’s found her raper?

domain: entertainment


text:
Company: Simpleware Product Group, SYNOPSYS NORTHERN EUROPE
Date of Enforcement Report: 8/18/2021
Simpleware ScanIP software. For transfer of imaging information from a medical scanner to an output file, and for simulating/evaluating surgical treatment options.
Recall Number: Z-2253-2021
A issue (bug) has been identified with the interface and image software which could result in anatomical orientation tags/labels being displayed incorrectly. This could result in operator misunderstanding and errors during resampling or re-alignment of image data.
Baxter Healthcare Corporation on 6/4/2021. Voluntary: Firm Initiated recall is ongoing.
VOLUME OF PRODUCT IN COMMERCE
U.S. Nationwide and International

domain: medical


According to Bersin by Deloitte “employee engagement has become the top issue on the minds of business leaders, directing us to a new model of management”.
Peter Wakefield of Loving Mondays talked about engagement being about connections. So when connections are lost, things go wrong for both the person and the employer.
But how many employers actually have engaged a tribe of people? It’s one thing to say you’re doing it – it’s another to actually be doing it. Great culture and engagement doesn’t just happen. And it starts at the beginning of the journey. In fact, the hiring process often gives an accurate reflection of the business itself. So in the workplace, who has the power to engage? Engagement has to come from the start and from the top. But on a day to day basis it also has to come from your manager. Studies tell us that people don’t quit a job, they quit a manager. So conversations to stimulate engagement shouldn’t be seen as an extra in a manager’s role – they are an integral part of the manager’s role and this must be valued by the organisation.
A couple of key points to note:
- Engagement isn’t a project, it’s a principle
- 80% of the UK mental health problems start at work – so what can we do to prevent this? The cost of this to a business is significant (£38bn annually in the UK)
- People are engaged by people primarily, not things
- 80% of an employee’s engagement is down to their relationship with their manager
According to Bersin by Deloitte, “employee engagement has become the top issue on the minds of business leaders, directing us to an entirely new model of management”.


archive.jsonline.com/.../autumn-radtkes-death-in-singapore-ruled-...Traducir esta página13 mar. 2014 - Waukesha County native Autumn Radtke's death at 28 in Singapore became a ...Douglas Abrams, who brought Radtke to Singapore to run his ...
https://www.reuters.com/.../ceo-in-apparent-suicide-was-bitcoin-fa...Traducir esta página6 mar. 2014 - Autumn Radtke, chief executive of virtual currency exchange First Meta Pte ... Douglas Abrams, director of First Meta, denied the company was ...
Powerful Forces Keep Bitcoin Heist Shrouded in Mystery, Alleges Bitcoin Entrepreneur
Bitcoin News (press release)-5/01/2018
According to RT's exclusive source, William Mook, Ms. Radtke “and her team and others ... Autumn Radtke's death was formally ruled a suicide.
Autumn Radtke, chief executive of virtual currency exchange First Meta Pte ... Douglas Abrams, director of First Meta, denied the company was ...
R.I.P. Autumn Radtke 28 yrs CEO of First Meta, a Singapore Bitcoin ... First Meta director Douglas Abrams confirmed Radtke's death on Feb. 27.


text:
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domain: game


text:
MADISON, WIS. (August 14, 2015) — John W. Vaudreuil, United States Attorney for the Western District of Wisconsin, announced that Uri Fried, 58, Waunakee, Wis., was sentenced August 12 by U.S. District Judge James D. Peterson to one year and one day in federal prison for filing a false tax return. Fried pleaded guilty to this offense on May 22, 2015.
Fried did business as a timeshare wholesaler. As part of the plea process, Fried agreed that his unreported income from this business between 2008 and 2009 was $1,980,035 and that he owed $706,636 in federal taxes for these two years.
Judge Peterson rejected Fried’s request for probation and stated that a prison sentence was necessary to promote respect for the law and to deter others who may be inclined to cheat on their taxes.
U.S. Attorney Vaudreuil stated that, “Uri Fried’s prison term should give confidence to the American taxpayers who choose to do the right thing by paying their taxes. With our partners at IRS Criminal Investigation, we will hold accountable those who willfully choose to hide income and refuse to pay their fair share.”
“Today’s sentencing of Uri Fried again emphasizes that the Internal Revenue Service and U.S. Attorney’s office will continue their aggressive pursuit of those who fraudulently attempt to evade their fair share of taxes,” said Shea Jones, IRS Criminal Investigation Special Agent in Charge. “Honest taxpayers have been reassured today that no one is above the law–especially when the virtue of tax administration is at stake.”
The charge against Fried was the result of an investigation conducted by IRS Criminal Investigation. The prosecution of the case has been handled by Assistant U.S. Attorney Timothy M. O’Shea.
PRESS RELEASE SOURCE: USAO – Wisconsin, Western District

domain: news


text:
Key Ingredients: Salicylic 2% / Glycolic Acid 2% / Green Tea / Cucumber / Zinc / Copper
Silybum– Silybum is essentially milk thistle seed. It contains high levels of vitamin E &fatty acids, including linoleic acid. It’s antioxidant benefits help protect skin from environmental stressors. In addition to these effects, milk thistle also soothes and moisturizes the skin.
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Green Tea Polyphenols- Green tea leaves contain polyphenols. The antioxidants provided by green tea are powerful against free radical damage. Green tea improves elasticity & increases moisture levels in the skin. The polyphenolic compounds present in green tea also provide natural anti-inflammatory effects to the skin. When applied topically, these compounds help address inflammatory conditions of the skin, including acne, dermatitis, and rosacea.
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domain: chemistry


text:
Within a prestigious award winning development, this first floor holiday apartment offers a quiet, peaceful location from which to explore the surrounding area. Situated only 500 metres from the spectacular rugged Ayrshire coastline and dominated by the dramatic Ailsa Craig, there are many coast and inland walks and cycle routes. The area is famed for its championship golf courses at Turnberry, Troon and Prestwick which are all within easy reach. Culzean Castle (NT) and The Burns Visitor Centre are among many attractions. There are many facilities in the busy seaside town of Ayr approximately 12 miles. Shop 3 miles, pub 800 yards.
Stairs or lift to entrance. All on first floor: Living room with French doors. Kitchen with tiled floor. 2 double (6ft zip and link) bedrooms, one with en-suite bathroom with bath, shower cubicle and toilet. Bathroom with bath, shower cubicle and toilet.
Gas CH, gas, elec, bed linen and towels inc. DVD. CD. Gas hob. Elec oven. Combi m/wave/oven/grill. Washer/dryer. D/washer. F/freezer. Shared garden. Parking (2 cars).
Customer Reviews of Milton Wynd, Turnberry, sleeps 4
1st comment: Fantastic property, 5* in a great position for visiting Ayrshire, loads of super National Trust places to visit. Sept 2011.
2nd comment: It was furnished and decorated to a high standard which suited us. Comfortable, convenient to get to with all modern conveniences. The are where the property is situated is beautiful and convenient for Turnberry Golf Course, and the surrounding area is scenic and refreshing. Sept 2010.
3rd comment: The property was well place in Turnberry and made visiting and returning from excursions very easy. It was very quiet, although near a main thorough-fare and the whole complex was nicely presented. The apartment was very spacious and nicely presented. Aug 2010.
4th comment: Well appointed, spacious, comfortable and clean property, with secure but easy access, good parking and all in an ideal location for our visit. Close to good golf courses and beautiful scenery, yet only a short drive from towns with supermarket & shops. Oct 2009.

domain: travel


text:
HOPE FOR BETTER TOMORROW
IMAGE BY MY FRIEND, KAEW. THANK YOU MUCH!
NOTE: That day was a Sunday, June 6th 2004 to be exact. I was so down from the night and weeks before. Lover problem, friend problem, school problem, I could say everything bad about my life and nothing good. I called a friend, planning to ask her out with me, she already had plan. So to kill some time, I went to Jatujak Market, it was very hot, I was sweating. I got tired of walking and left. I took the sky train to Siam, hoping to find a movie to watch, but the movie I wanted to watch was showing late. Then I tried the bookstore, I bought a book, "The Alchemist" by Paulo Coelho. I went to Starbuck to read, it was not quiet there, but I read the book anyway. The light outside started to low, it was time to go home. I took the sky train, walked to where my car was parked. I got home alright. Still have the rest of the night to go. I called my friend, see how she was. I talked to her about what I was feeling. I told her about Saturday night when I went clubbing, I had an argument with one of the drunk clubber and my friend just stood there. My friend failed to protect me, my family is not here to protect me, no lover to protect me. I am a strong person, unfortunately I can't always be strong. I believe that we all have these kind of feeling, when the world is down, you're lost, and no one is there. It's a perfect time to feel sad, thinking everything has fallen down. I just had to sleep, to regain my strength and hope for better tomorrow.

domain: literature


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text:
The bullpen is arguably the biggest area of debate right now, and that’s nothing new when it comes to putting together a collection of relievers. Just as they did last season, the front office managed to bring in a few veterans on MiLB contracts, giving some depth and strength to a young group.
What that also means is that they’ll have to make room on the 40 man roster for those MiLB contracts, as there has been no need to add those players just yet. The two that stand out in particular are the returning John Axford, and the newly acquired Bud Norris.
As of right now I would guess that the “locks” for the bullpen would include Ken Giles, Ryan Tepera, and Tim Mayza, with Joe Biagini being another likely candidate. My guess is that Axford and Norris will both make the team, which leaves one spot left, or maybe two if the Blue Jays decide to carry eight relievers to start the season.
If they do carry eight, the “extra” spot will almost assuredly go to Elvis Luciano, who was acquired from the Kansas City Royals in the Rule 5 Draft, and has to be brought north in order to be retained by the Blue Jays. Regardless of whether Luciano makes the team or not, I believe the Blue Jays would have one more spot to fill anyway, and Sam Gaviglio‘s performance during Grapefruit League play may have secured him that chance.
The big choice here regarding the 40 man roster is whether or not the Blue Jays will keep one or both of Axford and Norris. They’ve both looked solid this spring and project to be decent contributors, so chances are the Blue Jays will have to make some room for them.

domain: sports


text:
We seek justice for the unsolved murder and wish to see the killer convicted and held accountable.
States w/o Nations: ICE Locking Up 100s of US Citizens in Recent Yrs, Chgo Case Suggests ICE Obstruction of Justice tiny.cc/mvsa8x
America’s Secret ICE Castles via @thenation thenation.com/article/americ…
I liked a @YouTube video youtu.be/8W2hQeUB68k?a Detective Kenneth L. Mains Talks Cold Cases
@LaceyGaines9 #LaceyGainesMurder cold case, @DetectiveMains helps and is very good at what he does! twitter.com/DetectiveMains…

domain: law


text:
Zeroing In on Rosum
The startup -- co-founded in 2002 by one of the creators of the GPS satellite tracking system, James Spilker -- uses TV signals instead of radio waves from space.
The "TV-GPS" system fixes where a person or asset is by triangulating the distance via three or four different signals. "We use unmodulated TV signals," explains Jon Metzler, director of business development at Rosum. "It doesn't matter to us if it's Fox or CBS."
Using TV signals means that a receiver doesn't require a clear view of the sky to get a fix, which is what usually trips up GPS in urban settings. It does, however, bring its own limitations, as Metzler explains.
"We need three or more TV signals to triangulate, so this is really more effective in urban areas," he tells Unstrung.
With that in mind, Rosum is integrating its TV tech with GPS proper to try and provide full coverage in the town or country. According to Metzler, the Rosum receiver is currently "about the size of a credit card."
Metzler says that Rosum is definitely looking at the enterprise as a market for its technology, as well as public safety and other applications: "It's really designed for folks who really need to know where their stuff is at any given moment." (See Telematics on Track.)
The enterprise is a growth market for location services. In the U.S. today, there are already nearly 1.9 million GPS devices used to monitor business applications, according to market researchers C.J. Driscoll and Associates. By 2009, this market will expand to over 5.8 million units and annual hardware and service revenues will grow to over $2 billion, the researchers predict. Meanwhile In-Stat is predicting that the business market for location-capable handsets will grow from 582,000 devices today to 1.1 million devices by the end of 2010. (See Verizon Triangulates on Location Apps.)
Rosum's TV-GPS includes various forms of what is known as assisted-GPS that are also being tested and implemented by urban enterprises.
For instance, the New York Metropolitan Transit Authority (MTA) had been testing GPS systems for a while, initially with some problems, before awarding Siemens VDO a $7.2 million contract to install a GPS system called the Service Management and Customer Information System (SMCIS) on some buses and other MTA vehicles in the city.
"We hope to have this in place by the end of the year," says a spokesman for the MTA. "We had tried it in Manhattan before but it didn't really do so well because of the high buildings."
Spokespeople for Siemens where unable to confirm for Unstrung exactly what kind of assisted GPS has allowed it to improve the location performance. In the past, however, the unit has implemented systems that utilize fixed base stations at known positions to help find the location of a roving receiver.
— Dan Jones, Site Editor, Unstrung

domain: geography


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Easy to work with, understood what we wanted early on.
Designer was very creative I can’t wait to work with them again
Thanks for a quick delivery!
It was a pleasure working with Zulax. Zulax was responsive to my inquiries, had creative ideas and showed a great deal of patience as we worked through the finishing touches of the logo and website. I would highly recommend this designer.
- > joan <
The second time we have used Joan's service and both projects have been successful. Thank you.
Thanks for your patience!
How Dmorinaga started their logo & hosted website journey
Who are you known as?
What’s your company slogan?
Play live. Play hard.
Tell us a bit about who you are and the people you reach
We are a mobile platform that connects poker players to play live. Our target audience is primarily male, young professionals between 18-40.
What industry do you think your business is most related to?
Games & Recreational
What colors do you want to see in your design?
To give us an idea of the overall feeling of your brand, let us know which styles you lean towards
Creativity! the concept and the icon go in line.
Simplicity and sophistication at the same time with a cool color combination. Also liked the font used and the fact that they are all the same size.
The attached pictures are the actual screenshots from the mobile app.
What do you have in mind for the style and theme of the logo and hosted website?
We are looking for a modern style with a mix between dark grey (almost black), white and orange.
Jimdo templates to explore
The frames and style can be replicated from Uber's landpage but with a more creative touch.
1) Home page should be simple and to the point with space for a horizontal picture right below the top menu + a separate menu with those three boxes as to explain the concept. A login menu should be included as well.
2) We need another page for instructions to both players and hosts.

domain: artistic


We are here for your questions anytime 24/7, welcome your consultation.Get Price
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The noise of the teachers’ strike drowned out debate on the B.C. budget so thoroughly that one of Finance Minister Kevin Falcon’s more controversial ideas only made the news last week.
Reporters dubbed it “Welfare Air.” Falcon plans a pilot program to offer social assistance recipients training and airfare if they can line up a job in B.C.’s northern energy boomtowns. Workers are being imported to fill jobs there, while in Metro Vancouver and elsewhere the number of single employable people applying for social assistance is rising.
Much of oil and gas work is dirty and dangerous. These days most industrial jobs involve sophisticated electronics, and the technical skill level required is high. But there are entry-level jobs going begging, and relatively high pay is offered to fill positions in a short-staffed service sector in the Peace region.
NDP MLA Carole James, no stranger to northern B.C., dismissed Falcon’s plan as a stunt. There are unemployed people in the region who should be offered training before we start flying people up from Vancouver, James said.
Yet I repeatedly hear from northern employers that the labour shortage is real and growing.
The NDP warns that B.C. faces a future of “people without jobs, and jobs without people.” Mostly they blame the B.C. Liberals for removing apprenticeship programs from union control.
I spoke with James about post-secondary needs a couple of weeks ago. She mentioned NDP leader Adrian Dix’s signature policy to restore B.C. student grants, funded by a capital tax on financial institutions. She also agreed that part of the problem is young people taking post-secondary education that leads to fields with poor job prospects.
I suggested that if B.C. taxpayers are to increase their subsidy to post-secondary students, already worth about two thirds of their schooling costs, perhaps grants could be targeted to areas of pressing economic need.
To my surprise, James agreed that is worth considering. This is significant, not only because it is likely to be unpopular in the education establishment.
There is a good chance that James, a former school trustee, will be B.C.’s education minister in 14 months.
After writing about the labour shortage last week, I was bombarded with messages from an irate Vancouver high school teacher who mocked the whole notion as corporate propaganda. No labour shortage exists, globally or in B.C., he claimed. Rather, “capitalists” of the “one per cent” have tried to “vocationalize” public education for a century, but the “people” have always “resisted.”
Radical socialists aside, why would matching student aid to employment demand be unpopular with teachers?
Education Minister George Abbott offered a clue during the lengthy debate over ending the teachers’ strike. Abbott noted that for every three teachers coming out of B.C. universities, there is currently only one job available.
Certainly student debt is an issue worth discussing. And most would agree it’s easier to pay off loans if one can find a job in one’s field upon graduation. Should further subsidies go to soon-to-be-unemployed teachers? No.
Our education system trains too many people for what they want to do, rather than what the economy needs.
And our economy definitely does not need more kids taught Marxist claptrap.
Further to that, a tax on banks will be popular with some of today’s students, who protested against capitalism in the “occupy” camps that will resume as the weather improves.
Others will examine the idea and conclude that financial institutions will recover the tax from customers, and perhaps find ways to get the job done with fewer employees.
Tom Fletcher is legislative reporter and columnist for Black Press and BCLocalnews.com firstname.lastname@example.org

domain: finance


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Mirzapur is one web-series that has got me hooked on to it right from its pilot episode. So when I came across its fabulous posters on the Internet, I was indeed, very excited! Soon, I realized that the buzz of the show isn’t going to die down any time soon looking at those dark and gritty posters. Mirzapur fanboys and fangirls are here to stay!
It all began when Amazon Prime Video collaborated with Talenthouse and ran a contest where various Mirzapur fans submitted their entries.
#ContestAlertटैलेंट bahot hai भैया, मिर्ज़ापुर ka धमाकेदार poster banao aur inaam pao, नगद।@Talenthouse X @YehHaiMirzapur: https://t.co/TUV5YC6oTF #FanArt #Mirzapur Artist 1: @RicoMamboTeesArtist 2: #CedricChaArtist 3: #OjasParkhi pic.twitter.com/EujJ9jryu3— MirzapurAmazon (@YehHaiMirzapur) November 20, 2018
Here’s what Ali Fazal a.k.a Guddu Pandit posted on Twitter:
I guess we all agree with Fazal here. The poster was badass, raw and crude just like the show itself. Other fans too, showed their love for the show by letting their imagination run wild and came up with some killer posters!
Here are some of them:
Reza Maulana recreates the town of Mirzapur in entry, all while retaining its dark setting and old world charm.
Notice how there’s ‘Kings of Mirzapur’ written on the number plate. Such attention to detail! The edgy artwork is bringing to life the gritty atmosphere of the show and is perfect for someone who’d prefer a badass poster for his wall instead of a Pablo Picasso.
Pratap Chalke makes caricatures of Mirzapur gang and does full justice to the characters!
This entry is perfect if talk about its minute nitty-gritties that are aptly shown. And can we acknowledge how each character has its profound expression on face? Damn!
Cedric Cha even designed a minimalist artwork with Guddu’s face on it
Guddu’s name is infamously synonymous to guns and this entry is just the right artwork to give Guddu his much deserving homage; in a good way of course! The gun in the art is somewhere giving me the same eerie chills that the mask in V For Vendetta gave me.
Who says Indians can’t do minimalist art? Ye sab dekh ke...
10 winners of the contest were announced yesterday and you just can’t afford to miss out on these fab posters!
For now, I can only hope that the good folks at Amazon Prime Video give the fans of Mirzapur a plethora of merch; phone cases, tees, posters… The list is long. I guess all you Mirzapur fanatics agree!
Even if they don’t, we can always send Munna their way, can’t we? That will surely do the job!


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The U.S. Food and Drug Administration approved Phase 1 dose escalation study is evaluating the safety, tolerability and anti-tumor activity of PFK-158 in cancer patients with solid tumors such as melanoma, lung, colon, breast and pancreatic cancer.
PFK-158 is the first 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) inhibitor to undergo clinical trial testing in cancer patients. The target, PFKFB3, is activated by oncogenes and the low oxygen state in cancers, stimulates glucose metabolism and is required for the growth of cancer cells as tumors in mice. PFK-158, which has been licensed by ACT from the James Graham Brown Cancer Center at the University of Louisville, inhibits the substrate binding domain of PFKFB3 causing a marked reduction in the glucose uptake and growth of multiple cancer types in mice.
PFK-158 human clinical trials began recruiting patients in May with the first clinical trial site located at the James Graham Brown Cancer Center, a part of KentuckyOne Health. Within weeks of opening the first clinical trial site, ACT was able to open the second clinical trial site at Georgetown University Medical Center in Washington, also in May.
According to Jason A. Chesney, M.D., Ph.D., deputy director of the Brown Cancer Center and a global thought leader and researcher in cancer metabolism, “PFK-158 is not only a first-in-class cancer drug but also the first to target glucose metabolism by inhibiting PFKFB3. This unique mechanism of action has resulted in efficacy against a broad spectrum of human cancers caused by common mutations as well as synergy with targeted agents that are FDA approved for several cancer types.
“As a researcher, it is incredibly rewarding to witness your group’s studies move into clinical trials and potentially save the lives of cancer patients,” Chesney said.
“This is a significant milestone for ACT and it supports our dedication to develop significant treatment advancements for cancer patients with first-in-class, potential breakthrough therapeutics like PFK-158,” said Randall B. Riggs, president & CEO of ACT.
About Advanced Cancer Therapeutics (ACT):
ACT is a privately held company dedicated to advancing novel therapeutics for the prevention and treatment of cancer. ACT has successfully established a unique and innovative business model with the University of Louisville’s James Graham Brown Cancer Center whereby ACT is able to obtain exclusive worldwide licenses to novel cancer therapeutics discovered at Brown Cancer Center under preset business terms. ACT then fast-tracks these discoveries, including the selection process for partnership, commercialization and manufacture, to the pharmaceutical industry, and ultimately to the patients who need them. Led by Donald M. Miller, M.D., Ph.D., the Brown Cancer Center employs more than 50 scientists focused on the discovery and advancement of breakthrough cancer therapeutics for patients suffering from cancer. For more information, please visit www.advancedcancertherapeutics.com.
About the James Graham Brown Cancer Center:
The James Graham Brown Cancer Center is a key component of the University of Louisville Health Sciences Center. As part of the region’s leading academic, research and teaching health center, the cancer center provides the latest medical advances to patients, often long before they become available in non-teaching settings. The JGBCC is a part of KentuckyOne Health and is affiliated with the Kentucky Cancer Program. It is the only cancer center in the region to use a unified approach to cancer care, with multidisciplinary teams of physicians working together to guide patients through diagnosis, treatment and recovery. For more information, visit our web site, www.browncancercenter.org.

domain: biology


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Northwestern University Libraries have been a U.S. Federal Depository Library since 1876. Our collection includes materials in paper, microfiche, CD-ROM, DVD formats and online formats. This guide is based on a similar guide by Kelly Smith at UCSD.
Presents statistical indicators containing text, figures, and tables describing important developments in the status and trends of education from early childhood learning through graduate-level education.
Contains information on a variety of subjects in the field of education statistics, including the number of schools and colleges, teachers, enrollments, and graduates, in addition to educational attainment, finances, federal funds for education, libraries, and international education.
Provides collections and information services to the public, education community and other government agencies on current and historical programs, activities and publications of the U.S. Department of Education; federal education policy; and education research and statistics.

domain: library


Shaun powered team of apprentices to cut costs and carbon footprint at sawmill
A former apprentice is helping his employer BSW Timber to chop its carbon footprint and potentially save tens of thousands of pounds as it aims to hit net zero.
Innovations through a team of apprentices but driven by Shaun MacLeod through the Fuel Change Competition included the idea of introducing a new electric powered mobile side-loader plant to the mill in Fort William.
The initiatives that were found by the 21-year-old and his team, then reviewed, offered new ways of working and could potentially deliver annual savings of £400,000 a year for the timber mill, with the added opportunity to cut carbon emissions by thousands of tonnes per year.
These findings link to BSW Timber's business standards of tradition and integrity combined with high-tech innovation. As a business, the firm takes pride in trying to be ever more cutting edge and to deliver zero-waste principles and recovery of 100% of resources. Its business has a robust strategy based on long-term expansion and sustainability.
He completed his apprenticeship in November 2021, learning lots along the way and is now studying for an HNC qualification at UHI Inverness College.
Shaun said: “Technically, I really progressed my learning in electrical and mechanical areas and my understanding of industrial manufacturing through my apprenticeship.
“My apprenticeship has also helped me massively with my personal skills, my confidence, and being able to communicate with others.”
I'm currently in a mentor role for the younger apprentices who are going through the Fuel Change Challenge and so this has helped with my leadership skills.
Shaun’s innovative business solution was borne from participating in the Fuel Change Challenge, which is a low carbon innovation challenge open to apprentices across Scotland.
Shaun said: “I've always thought about the environment. I was a part of the eco committee at school and I'm very into conserving the outdoors. BSW Group gave me the opportunity to be part of the Fuel Change Challenge with the rest of the team.”
The positive experience he gained through Fuel Change has led Shaun to support others participating in other projects at BSW and with local community projects.
He explained: “I'm currently in a mentor role for the younger apprentices who are going through the Fuel Change Challenge and this has helped with my leadership skills.”
Tony Lockey looks after apprenticeships, graduates and learning development at BSW Group. It has about 1,200 staff across the UK, with about 230 employees at the Fort William Mill.
Tony said: “The Fuel Change Challenge is a competition that tasked groups of apprentices to come up with real time solutions that would help their employers cut carbon emissions. This is incredibly exciting and offers young people the opportunity to make real changes to improvements at work and in our lives.
“Shaun saw getting involved in Fuel Change as a fantastic opportunity to highlight his ideas, to cascade key messages of improving new zero carbon ambitions and to share findings with a wider audience.
“Shaun has a real appetite for anything new and has good ideas about how to improve things. Shaun became a leader on the Fuel Change Challenge. He grabbed it with both hands.
“Shaun has become our ambassador for net zero by taking part in podcasts with the Fuel Change Team, attending events and adding value at these. He is inspirational to the new apprentices and existing teams.”
Shaun saw getting involved in Fuel Change as a fantastic opportunity to highlight his ideas, to cascade key messages of improving new zero carbon ambitions and to share findings with a wider audience.
An apprenticeship has helped Shaun realise his dream of following in his grandfather's footsteps.
Shaun said: “My grandfather passed away when I was three months old. He was highly regarded as a good electrician in the area and I thought I'd like to follow in his footsteps. That's how I got into my electrical apprenticeship.
“I decided an apprenticeship would be best for me because prior to leaving school I was working in a bike shop at weekends and I enjoyed working with my hands. I thought an apprenticeship would let me learn on the job.
“The main benefit of the apprenticeship for me is that I’m getting to learn hands on. Through my apprenticeship I work with so many different tradesmen and learning different ways of doing things. Also, with the college, you are getting that underpinning knowledge. I’m achieving all this and getting paid at the same time.
Shaun was a finalist in the Supporting Net Zero Apprentice category proudly sponsored by Ocean Winds at the Scottish Apprenticeship Awards.
Shaun said: “It's absolutely fantastic to be a finalist in the Supporting Net Zero Apprentice category. I'm ecstatic. It's really nice to have not only my own work recognised, but also the work of the rest of the team. Hopefully this help to widen everyone's views on what they can do to reach net zero.”
BSW Group has reaped the benefits of employing apprentices for many years.
Tony explained: “We actively employ and see real benefit it employing a range of different types of apprentices, from engineering disciplines, administration, marketing, and IT basically right across the board.
“This is a very exciting time in our industry. Our business needs young people to help take BSW Group into the future. Our apprentices have been fantastic and we see real benefit through succession plans and in the drive and energy they bring.
“Apprenticeships as key to our business. They help us integrate with our local communities especially as we are based in the main in rural areas - apprenticeships offer fantastic career opportunities. I have found that apprentices bring ideas, enthusiasm and energy from day one, to our business.
“From the moment Shaun came for interview with us he has shown real dynamism. I've never forgotten his home-made clock he brought as a show and tell. Time has certainly taught us that Shaun is a great asset to engineering.”
Pippa Le Fevre of UHI Inverness College said: “The BSW and UHI relationship is an incredibly positive one through the apprenticeship programme.
“Shaun has been a great apprentice to work with. Throughout his apprenticeship he was always positive, produced work of an excellent standard and was methodical and consistent in his approach to all of his activities, including looking at ways to make his role better through environmental and sustainable options.”
Scottish Apprenticeship Awards
The winner of the Supporting Net Zero Apprentice category sponsored by Ocean Winds was revealed at this year's Scottish Apprenticeship Awards, organised by Skills Development Scotland.
To find out more about the winners, and how apprenticeships can benefit young people and employers, visit Apprenticeships.scot/awards


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Biology of Foodborne Parasites (Food Microbiology)
By Lihua Xiao, Una Ryan, Yaoyu Feng
Series: Food Microbiology
Hardcover: 520 pages
Publisher: -- (April 13, 2015)
While a number of introductory books on basic and molecular biology are available, none highlight the foodborne parasitic pathogens. Until now. Astate-of-the-art review, Biology of Foodborne Parasites charts significant progress and outlines key biological techniques applied to foodborne parasitic pathogens research. The book covers basic biology, genetics and genomics, epidemiology, pathogenesis, diagnosis, control, and prevention. It showcases recent research that can then be used to spark further breakthroughs.


Digital Transformation Strategy in Manufacturing Industry – Business Transformation Trends for 2020
What is Digital Transformation? Is it just a Tech Trend?
Digital transformation is the process of using digital technologies to create new — or modify existing — business processes, culture, and customer experiences (CX) to meet changing business and market requirements. The reimagination of business for the digital age is digital transformation.
Digital Transformation in Manufacturing Industry
While leaders in manufacturing transform to optimize processes, improve the customer-centric experience, risk mitigation, innovate, grow revenues and, most of all, penetrate wholly new revenue streams with innovative business models, revolving around information and services, while slow adaptors remain to focus on just the optimization aspect.
Like the Industrial Revolution changed manufacturing, digital transformation is presently responsible for changing the industry. Industrial machinery manufacturers are joining other industries and are moving to a more digitized world. Now, manufacturing companies are using technology to move from mass production to customized production, and it’s happening at a rapid pace. Since Henry Ford introduced mass production now is the time that there has been a revolution at this scale.
Buyer expectations and the arrival of connected devices and platforms are driving the persistent digitization of the manufacturing industry. While the majority of manufacturing execs recognize the significance of digital transformation strategy, A GT Nexus study found only 5 percent of those surveyed were very satisfied with their digital progress so far. The industry remains to evolve in response to the challenge of ensuring the right products are delivered at the right price to the right person through a process of improved sophistication.
Three large challenges in the manufacturing industry
Economic, geopolitical and consumption ambiguities – the demand for efficiency
As history at the end of 2016, 2017 and the next years on and beyond, The manufacturing industry is going through extremely uncertain times and unpredictability regarding consumer spending on one hand and geopolitical and economic conditions.
European companies are mobilizing to drive the Industry 4.01 vision forward, amidst the growing uncertainty (Brexit uncertainties) even faster than before. Also in other parts of the world initiatives are taken in an undeniable reality where globalization has gone from a piece of evidence for many to a source of distrust for many others.
|1 Industry 4.0 refers to a new phase in the Industrial Revolution that focuses heavily on interconnectivity, automation, machine learning, and real-time data. Industry 4.0 encompasses IIoT (industrial internet of things) and smart manufacturing, coupling physical production and operations with smart digital technology, machine learning, and big data to create a more holistic and better-connected ecosystem for companies that focus on manufacturing and supply chain management.
The customer factor: from speed to better products, services and customer experience
Once these efficiencies and the rather process-oriented and Industrial Internet objectives we’ve just mentioned are achieved, innovative opportunities arise and efforts are done, looking more at customer-facing optimization and innovation. Automation, optimization and efficiency- and cost-driven goals do have a customer-centric goal.
Automation multinational and Industry 4.0 pioneer ABB (Asea Brown Boveri, Swedish-Swiss multinational) took in the area of industrial robotics is a good example of how these advantages can be obtained.
Bertil Thorvaldson, Product Manager, ABB Robotics said “The power of the Internet of Things comes from the ability to collect a lot of data and convert that into useful information”
The company produces industrial robots and manufacturing services for a variety of industries, reaching from automotive to electronics. The industrial manufacturing robots they produce are not the kind of robots you would see at the Consumer Electronics Show but robotics systems as they are mainly used for manufacturing. ABB is selling such industrial robots, and provide a series of services.
Competition and the disruptive impact of manufacturers who have transformed at the core
A third element and also an unavoidable result of the first two is closer to digital transformation at the core – in the business models and the detection of new information-driven and connected revenue opportunities in the ‘as a service’ evolution.
By 2020, Manufacturers Will Capture 20% More Aftermarket Revenue by Using Product and Service Quality Measures to Enhance Customer Experiences.
According to the research of The Boston Consulting Group, released at the end of 2016, that many manufacturers see Industry 4.0 as a priority but relatively few look at the possibilities to tap into new revenue sources, let alone increase revenues.
3 Big Trends in Digital Transformation in Manufacturing
IoT and Industry 4.0
At the center of industrial transformation is IoT, accounting for more than $178 billion in 2016 and proving critical to providing businesses with a competitive edge. The manufacturing industry is heading towards IoT because of the revolutionary ways this connected technology has streamlined and simplified various manufacturing processes.
AI and Machine Learning
A machine’s ability to learn and adopt intelligent human behavior is not a new advancement. Today, these advanced algorithms are transforming the way the manufacturing industry collects information, performs skilled labor, and predicts consumer behavior. Smart factories with integrated IT systems provide relevant data to both sides of the supply chain more easily, increasing production capacity by 20%.
Quality is no longer sacrificed for efficiency, as machine learning algorithms sensors have replaced human hands, resulting in less wasted time and materials, as well as optimal accuracy and workflow. Digitizing the industry means lower cost of production, quicker turnarounds, and more efficiently meeting customer demand.
Data and Analytics
By 2020, the digital universe will increase to 44 trillion gigabytes, yet most companies are still incapable of dealing with the flow of information across their extended enterprise. International Data Corporation predicts massive fifty-fold growth in digital content from 2010 to 2020.
90% of it will be unstructured information like emails, documents, and videos. Big data adds to the content management challenge, making it larger and more complex.
To stay with these expectations, implement the best digital transformation strategy to transform the way businesses operate and share product data across the business, improving production and clarity, and reducing cost and downtime.
Currently, the manufacturing industry is the largest to implement the Internet of Things to deliver an enhanced CX to their customers. As a business owner, you must be addressing the obstacles that stop you from scaling up your business.
We, at TechAffinity, have expert developers who can develop on your digital transformation strategy and prepare you for Industry 4.0. Want to know more? Shoot your queries at firstname.lastname@example.org or get in touch by scheduling a meeting.