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Your Mind Sharp and Clear with These Tips
Are you ready to tap into the power of your mind and unlock its full potential? We all know how important it is to keep our brains in top shape, and this article is the perfect guide to help us do just that.
Are you ready to tap into the limitless power of your mind and take control of your mental wellbeing? This article is the ultimate guide to unlocking the full potential of your mind, keeping it sharp, clear, and ready to tackle any challenge that comes your way.
From simple practices like meditation to organizational techniques, we’ve got everything you need to keep your mind in tip-top shape. Imagine feeling a surge of mental clarity and focus that allows you to take on any task with ease and confidence, no matter how daunting.
With the power of these mind-stimulating techniques, you’ll be amazed at the positive changes you’ll see and feel. So let’s make a commitment to ourselves and our mental wellbeing by diving into this article and taking control of our minds.
It’s time to clear out the clutter, silence the noise, and unlock the incredible power of our minds. Together, we can keep our minds sharp, clear, and ready to take on anything that comes our way. Let’s unleash the full potential of our minds and live our best lives yet!
Table of Contents
Are you looking for a way to clear your mind and improve your mental wellbeing? Regular exercise may be the answer you’ve been searching for! Exercise is one of the best things you can do for your mind and body. It not only improves your physical health but also has numerous benefits for your mental health.
Exercise has been shown to reduce stress, anxiety, and depression, all of which can clutter your mind and make it difficult to focus. By moving your body and releasing those feel-good endorphins, you can boost your mood and improve your mental clarity.
Additionally, exercise increases blood flow to the brain, which helps to stimulate the growth of new brain cells and improve cognitive function. So if you want to keep your mind clear and sharp, make sure to get moving!
Imagine feeling a sense of mental clarity and focus after a great workout. With the power of exercise, you can tap into the incredible potential of your mind and achieve your goals with ease. So let’s lace up our sneakers, hit the gym, and take control of our mental wellbeing. Your mind and body will thank you for it!
What Types of Exercise Are Best for Brain Health?
There are so many different types of exercise to choose from, and each one can have a powerful impact on your brain health and function.
Aerobic exercise like running, swimming, or cycling can get your heart pumping and increase blood flow to the brain, promoting the growth of new brain cells and improving cognitive function. Strength training is also a great option, as it helps to reduce cognitive decline and keep your brain functioning at its best.
And if you’re looking for something that’s gentle and calming, activities like yoga or tai chi can improve coordination and balance while reducing stress and improving cognitive function.
So why not try out a new exercise today and give your brain the boost it deserves? You’ll be amazed at how good it feels to move your body and stimulate your mind. Let’s take care of ourselves, both body and mind, and live our best lives yet!
Mindfulness is an incredible tool that can help you clear away that mental clutter and focus on what really matters. By being present in the moment and paying attention to your thoughts and feelings without judgment, you can reduce stress, improve cognitive function, and enhance your overall mental wellbeing.
And the best part? Mindfulness can also help you cultivate a greater sense of self-awareness and self-acceptance. You’ll learn to let go of negativity and embrace positivity, leading to a more optimistic outlook on life.
So why not give mindfulness a try today? It’s a simple yet powerful way to stay focused, clear-minded, and in tune with the present moment. Embrace the power of mindfulness and unlock its incredible benefits for your mind and wellbeing!
How Can You Practice Mindfulness?
When it comes to mindfulness, there are countless ways to practice, but one of the most straightforward methods is to focus on your breath. Take a few deep breaths and hone in on the sensation of your breath moving in and out of your body. If your thoughts wander, simply bring your attention back to your breath. Another way to practice mindfulness is to pay attention to your senses, like the feeling of your feet on the ground or the sound of the birds chirping outside. Lastly, you can incorporate mindfulness into your daily routine by staying present during activities like eating or walking, and really taking in the sensations of the moment.
Mindfulness can be a powerful tool to help you find peace and balance in your life. By taking a few moments to focus on your breath or senses, you can cultivate a deeper sense of awareness and appreciation for the world around you. Whether you’re feeling stressed, overwhelmed, or just want to enhance your overall well-being, mindfulness is a great way to connect with the present moment and find a sense of calm within yourself. So go ahead and give it a try – you might just be surprised at the positive impact it can have on your life!
There’s something truly magical about creativity. It has the power to lift our spirits, breathe new life into our souls, and infuse our world with color and wonder. Whether we’re painting, writing, or playing music, these creative activities allow us to tap into our innermost thoughts and feelings, inspiring us to unleash our imaginations and problem-solving skills to create something new and unique.
The benefits of creativity are truly endless and transformative. Engaging in a creative endeavor can help us to reduce stress, promote inner peace, and boost cognitive function. It’s a way to break free from the monotony of daily life, and to let our minds wander free, without any limits or constraints.
But at its heart, creativity is about self-expression and exploration. Through art, writing, or music, we can dive deep into our inner world, discovering new facets of our personality and gaining a greater sense of clarity and emotional well-being. It’s a way to connect with our true selves, and to rediscover the beauty and wonder of the world around us.
So if you’re feeling stuck or overwhelmed, why not make time for creativity in your life? Whether it’s for a few minutes a day or a few hours a week, engaging in a creative activity can help you stay connected to your true self and live a more joyful, fulfilling life. Allow your heart to guide you, and let your creativity lead the way – you never know where it might take you. So go ahead, take that first step, and see where your imagination can take you.
What Types of Creative Activities Are Best for Brain Health?
Do you ever feel like you’re living life on autopilot, going through the motions without truly feeling alive? It’s time to awaken your senses and ignite your passion for life through the power of creativity.
Whether it’s playing an instrument, writing a story, or painting a beautiful landscape, creative activities can have a profound impact on our mental and emotional well-being. Engaging in these activities can help us tap into our innermost thoughts and feelings, and discover new facets of ourselves that we never knew existed.
At the same time, creative activities can be a powerful tool for reducing stress and promoting relaxation. They allow us to escape the pressures of daily life, and to focus on the present moment with a sense of calm and serenity.
So if you’re feeling lost or uninspired, why not make time for creativity in your life? Whether it’s for a few minutes a day or a few hours a week, engaging in these activities can help us discover our passions, connect with others, and find true meaning and purpose in our lives. So go ahead, let your creativity shine, and discover the transformative power of the arts!
Are you feeling overwhelmed, stressed, or like you’re just not able to think clearly? It may be time to focus on one of the simplest yet most important things you can do for your brain health: getting enough sleep.
When we sleep, our brains work hard to consolidate memories and transfer them from short-term to long-term storage. This means that getting enough sleep is crucial for retaining important information and improving our cognitive function.
But the benefits of sleep go far beyond memory consolidation. Adequate rest can also help to reduce stress, promoting a sense of calm and inner peace that can improve mental clarity and overall well-being.
So if you’re struggling to stay focused or feeling like you’re in a mental fog, prioritize getting a good night’s sleep. Your brain and body will thank you for it, and you’ll wake up feeling refreshed, rejuvenated, and ready to tackle whatever challenges come your way. So snuggle up under the covers, close your eyes, and let your brain recharge.
How Much Sleep Do You Need?
It’s important to remember that the amount of sleep we require can vary from person to person, and can even change as we age.
As a general rule, most adults require between 7-9 hours of sleep per night. But it’s important to listen to your body and pay attention to how you feel after different amounts of sleep. Children and teenagers typically require more sleep, while older adults may need slightly less.
Getting enough sleep is crucial for maintaining our physical and mental health. It allows our bodies and brains to rest and recharge, promoting emotional well-being and mental clarity. So if you’re feeling run down or struggling to concentrate, consider prioritizing getting a good night’s sleep.
Investing in your sleep health can pay off in big ways, helping you to feel more energized, focused, and emotionally balanced. So why not snuggle up under the covers and give your brain the rest it deserves? You might just wake up feeling like a whole new person!
Food is not just about satisfying our hunger, but also about nourishing our bodies and minds. It’s about giving ourselves the gift of vitality, clarity, and emotional well-being. When we eat a healthy diet filled with nutrient-rich foods, we’re providing ourselves with the essential building blocks for optimal physical and mental health.
A diet that is high in fruits, vegetables, whole grains, and lean protein can have a profound impact on our physical health, helping to protect against disease and support healthy aging. But it’s also important to remember that what we eat can affect our mental health as well.
Certain foods, such as omega-3 fatty acids found in fatty fish and nuts, have been shown to improve cognitive function and reduce the risk of cognitive decline. And studies have linked diets high in processed foods and saturated fats to an increased risk of depression, anxiety, and other mental health issues.
So when you choose what to eat, think about how it will nourish not only your body but also your mind. Prioritize whole, nutrient-dense foods and limit your intake of processed foods and saturated fats. Treat yourself to the nourishment you deserve, and watch as your energy, focus, and emotional well-being soar.
What Foods Should You Eat to Keep Your Mind Clear and Stimulated?
The foods we eat can have a powerful impact on our mental and emotional well-being. When we prioritize nutrient-rich, brain-boosting foods, we give ourselves the gift of clarity, focus, and vitality.
In addition to the brain-boosting foods mentioned before, here are a few more to consider:
• Fatty fish, such as salmon and tuna
• Nuts and seeds, such as almonds and pumpkin seeds
• Whole grains, such as brown rice and quinoa
• Berries, such as blueberries and strawberries
• Leafy greens, such as spinach and kale
• Lean protein, such as chicken and turkey
Did you know that staying hydrated is not only important for your physical health but also for your mental clarity and focus? Dehydration can leave you feeling sluggish, fatigued, and unable to concentrate, which can make even the simplest tasks seem like a chore.
By making sure you drink enough water throughout the day, you can help to keep your mind clear and sharp. Drinking water helps to flush toxins from your body and can improve cognitive function, making it easier to think, learn, and remember. And let’s not forget the added bonus of hydrated skin, making you look and feel your best.
So why not make hydration a priority in your daily routine? Whether it’s carrying a water bottle with you wherever you go or setting reminders to drink water throughout the day, staying hydrated is an easy and effective way to support your overall well-being. So go ahead, take a sip, and feel your mind and body come alive.
How Much Water Should You Drink?
Did you know that water is more than just a thirst-quencher? It’s a vital source of life that can help to keep your mind and body healthy and energized.
Drinking enough water can help to flush toxins from your body, improve cognitive function, and keep your skin glowing and healthy. But it’s not just about drinking eight glasses of water a day; it’s about making hydration a habit and a lifestyle.
So why not make hydration a part of your daily self-care routine? Whether it’s carrying a water bottle with you wherever you go, setting reminders to drink water throughout the day, or incorporating water-rich foods into your diet, there are many ways to stay hydrated and support your overall well-being.
Remember, your body and mind deserve to be nourished and hydrated. So go ahead, take a sip, and feel the refreshing power of water revitalizing your entire being.
Keeping your mind sharp and clear is vital for a healthy and fulfilling life, and one way to achieve this is by challenging your mind. By engaging in activities that require mental effort, such as learning a new skill or solving a puzzle, you are not only stimulating your brain, but also helping to improve cognitive function and reduce the risk of cognitive decline.
When you challenge your mind, you open up new pathways and connections in your brain, helping to keep it agile and adaptable. Whether it’s reading a challenging book, trying a new hobby, or even just engaging in a stimulating conversation with a friend, there are endless ways to challenge your mind and keep it sharp.
So why not make it a priority to challenge your mind every day? It doesn’t have to be something complicated or time-consuming – even small activities can make a big difference. By keeping your mind engaged and curious, you’ll be better equipped to face whatever challenges life throws your way, and to lead a happier, more fulfilling life.
What Types of Activities Are Best for Challenging Your Mind?
There are so many possibilities out there, and each one can offer its unique benefits.
For instance, have you ever tried solving a particularly tricky puzzle or brain game? The rush of satisfaction you feel when you finally crack the code is like nothing else! And it’s not just about the thrill of the solve, either. These types of activities really engage your critical thinking skills and can help you stay mentally nimble.
But that’s not all. Learning a new skill, like playing an instrument or picking up a new language, can be an incredible way to boost your cognitive function and memory. It’s like giving your brain a workout, and the results can be truly remarkable.
And let’s not forget about the power of reading, writing, and doing math. These activities can be surprisingly challenging, especially when you push yourself to explore new ideas or tackle complex problems. But the payoff is enormous – a mind that’s clear, sharp, and ready for anything.
So if you’re looking to challenge your mind and keep it in top shape, don’t be afraid to explore all these different options. With a little effort and a lot of curiosity, you might just unlock new levels of mental agility and creativity that you never knew were possible!
Q: How do I know if my mind is not clear?
As we embark upon the journey of exploring the intricacies of the human mind, it becomes apparent that certain signals may emerge, hinting towards a lack of mental clarity. These signs may manifest in the form of struggling to maintain focus, memory slips, feeling inundated with a sense of helplessness, and incessant thought patterns, that seem to have no end in sight.
It is in these moments of vulnerability that we must pay heed to the nuances of our consciousness and take proactive measures to address any concerns that may arise. For it is only through self-awareness and a deep understanding of our own psyche, that we can truly unlock the infinite potential of our being.
Let us, therefore, be mindful of the whispers of our mind and not shy away from seeking the help we need to navigate the ebbs and flows of life. For it is only by taking charge of our mental health that we can lead a life of purpose, passion, and fulfillment.
Q: How can stress affect mental clarity?
Stress, oh how it wreaks havoc on the mind! The mere thought of it can make one’s blood boil and heart race. It’s no secret that stress has the power to cloud our thoughts, making it nearly impossible to see through the fog of worry and anxiety. But did you know that stress can also impact our cognitive abilities in a significant way?
Indeed, when we’re under stress, our bodies release a flood of hormones that can disrupt the delicate balance of our cognitive function. It’s like a storm brewing in the brain, with lightning bolts of cortisol and adrenaline striking at random intervals, leaving us dazed and confused.
And the worst part is that this cognitive interference can have a lasting impact on our mental clarity. Our ability to focus and think clearly can suffer, leaving us feeling overwhelmed and unable to keep up with the demands of our daily lives. It’s like we’re stuck in a thick fog, unable to see the path ahead.
But fear not, for there are ways to combat this cognitive storm. By taking steps to reduce stress in our lives, we can calm the storm and restore the balance of our cognitive function. Whether it’s through meditation, exercise, or simply taking a few deep breaths, we can find our way out of the fog and back to a place of mental clarity and peace. So let us all take a deep breath, release the tension in our bodies, and reclaim our cognitive clarity!
Q: Can meditation help to improve mental clarity?
Meditation can be a powerful tool for improving mental clarity, reducing stress and anxiety, and improving focus and concentration. If you’re looking to transform your life in positive ways, give meditation a try. With regular practice, you’ll be amazed at how much better you feel both mentally and physically.

domain: psychology


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158 - A Whole Different Leman Russ
With my hybrid/modified Russ being worked on, I thought I'd take the time to show you one of the other tanks I've been building recently - another Leman Russ, but this one has some skills!
Looks like a rather unassuming Leman Russ, except for the scrape marks and super glue fog on the side of the tank. This is one of the new Russ' and I had to smooth down the areas where the sponsons would be. This was because the protruding areas were getting in the way of my attempts at magnetising the sponsons.
Here are my magnets on one of the sponsons. Again lots of super glue fog, but the sponson weapon will still rotate properly. I was then able to hold the sponson in place on the side of the tank using some more magnets. With the magnets still holding everything together, I drew around them with a pen. The magnets were then taken out the way. Using the pen marks as a guide, I put some super glue in each place and then replaced the magnets, with the matching sponson on the other side so that things were definitely lined up.
Once the super glue had dried, I followed the advice from a couple of tutorials that suggested using green stuff around the magnets to really make sure they don't go anywhere.
I was out of green stuff, so used the modelling putty I had instead. It seems to have worked just as well, but was a pain to put on. Naturally I went over the top and used loads.
I wasn't finished magnetising just yet though. The turret was next and can be seen above in Executioner guise.
Well both the main weapon and the rear detail are magnetised and can be changed. Unfortunately, I didn't take a photo of the magnets inside the turret that hold the rear detail piece in place, but it was a similar process to the sponsons.
Here is the underside of one of the detail pieces - just two magnets glued in the corners.
For the main weapons, I drilled out a hole in the centre of the mounting bracket. I then put a small magnet in place.
The weapon itself was the same thing. Small hole, small magnet. I think a slightly bigger magnet would work better though.
That was all of my magnetising for this tank. And you can see it in Demolisher form with the sponsons above.
It can of course be used as a Punisher as well.
Here are all of the bits and pieces laid out.
A nice simple way of getting the most out of the kit. This was probably the easiest bit of magnetising I have done.
Thanks for reading. Comments and suggestions are always appreciated.

domain: artistic


Space debris tracking is a challenge for spacecraft operation because of the increasing number of both satellites and the amount of space debris. This paper investigates space debris tracking using marginalized δ-generalized labeled multi-Bernoulli filtering on a network of nodes consisting of a collection of sensors with different observation volumes. A consensus algorithm is used to achieve the global average by iterative regional averages. The sensor network can have unknown or time-varying topology. The proposed space debris tracking algorithm provides an efficient solution to the key challenges (e.g., detection uncertainty, data association uncertainty, clutter, etc.) for space situational awareness. The performance of the proposed algorithm is verified by simulation results.


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Evidently, our aldermen have already solved all of Chicago`s weighty problems and great issues, and were so bored from having nothing better to do that they`ve declared war on corner newsstands.
City Hall has already put many small newsstands out of business. Like David vs. Goliath, scrappy newsstand owner Rick Graff alone is fighting City Hall to stay in business on Randolph Street at Garland.
Newsstands are a public benefit, not a public nuisance. To justify this much political and legal exertion over such a benign, trivial issue, what else but money could be at stake?
The most likely beneficiaries of lessened competition are owners of newsstands in building lobbies, L-stops, hotels and bookstores-who happen to have more clout than sidewalk operators. If put to public referendum, it`s unlikely such pernicious legislation would ever pass.
Newsstands aren`t expected to be gems of architectural splendor. They`re purely functional, even gritty, but inoffensive. Unlike coin-operated newspaper vending machines, they make change and offer variety.
Our aldermen should call off the dogs and scrap their anti-newsstand legislation. There are far better uses for city government`s time and tax dollars than suing sidewalk newsstand operators out of existence and onto the unemployment or welfare line.

domain: politics


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Washington, D.C. (WIVB) — Feeding America, a national organization focused on providing equal access to nutritious food, reports that as many as one in five children in the state of New York could battle hunger every day. More specifically, the organization’s Map the Gap study showed that about 18% of children in Erie County are food insecure. That equates to about 34,000 children.
Anne McKenna, the marketing director for FeedMore Western New York, said the pandemic caused a spike in the people using the food bank.
“I would say we’ve seen a rise in services overall,” McKenna said. “Over the past year, whether it’s, you know, children in need of food assistance, older adults in need of home delivered meals. Overall we’ve seen a very significant increase during the global pandemic.”
Additionally, McKenna said that the poverty amplified by COVID-19 led to the high numbers of food insecure children.
“The level of poverty in Western New York, as well as the inequitable resources that are available to families who are already struggling really contribute to childhood food insecurity,” McKenna said.
Child food insecurity extends beyond Western New York. The U.S. Department of Agriculture claims there could be as many as 12 million children nationwide that battle hunger. Crystal FitzSimons, the director of school and out-of-school programs for the Food Research and Action Center, said food insecurity can have serious negative physical consequences for children.
“Kids who are food insecure are more likely to be less healthy,” FitzSimons said. “They’re more likely to miss days of school. They’re more likely to be ill. They’re more likely to be hospitalized. It has a pretty dramatic impact on kids’ homes.”
FitzSimons also said food insecurity can cause mental health issues for children.
“They’re more likely to be depressed,” FitzSimons said. “They’re more likely to have anxiety in the classroom. Kids are more likely to misbehave if they’re hungry.”
Obesity is another possible result of food insecurity among children. According to the New York State Health Department, about 36% of middle school and high school students are classified as obese in Western New York. This is significantly higher than the national average of roughly 21%.
FitzSimons said there are a number of factors stemming from food insecurity that can lead to obesity.
“A lot of low income communities are food deserts where they may not have a grocery store and it’s harder to access fruits and vegetables,” FitzSimons said. “And there’s a cyclical nature around food insecurity where at the beginning of the month, families might be in a better place. But by the end of the month, they are cutting back on meals or cutting back on the amount of food that is part of a meal.”
Despite the magnitude of the problem, McKenna said that both local and national food banks are expecting a significant number of people to use food banks for the next five-seven years.
“It’s one thing to lose your job and start falling behind, but trying to catch back up is very difficult,” McKenna said. “And food is something that we are able to provide to help these people get back on their feet. Sometimes it can be really difficult to find another job that can actually replace that position. There’s a lot of factors that go into it. But we do expect that this is going to last quite a long time.”

domain: sociology


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This Producer Loops Free Demo Pack Bundle includes 5 demo sample packs:
Supalife Tech House
Deep Funky House Vol 1
Supalife Classic Trance Vol 1
Euro House Vol 4
Supalife Tech House sets the standard yet again, bringing you FIVE multi-format Construction Kits packed full of minimal percussive top loops, FX builds & rises, vocal fragments, deep throbbing bass lines and more. MIDI, one-shots and a range of other professional features make this an utterly unmissable pack.
Deep Funky House Vol 1 kicks off a new series from Producer Loops featuring FIVE deep and atmospheric, royalty-free funky House Construction Kits, bringing you the finest shuffled grooves and club grooves vibes. Sparse bass lines, strings, chopped vocals, pads, rich FX and killer drums & percussion make this an unmissable pack!
Dubstep Chillout was produced for Producer Loops by Thomas Gomez of Supalife Records. It comes jam-packed with approaching 4 GB of loops, samples and MIDI files (per format) including cone-shaking bass loops, hard-edged drums, mystical atmospherics, blissed-out vocals, high energy FX, dance floor melodies and rhythms, all wrapped up in warm glistening pads, keys and spine-chilling synths.
Supalife Classic Trance Vol 1 is an energetic and euphoric blend of classic Trance vibes produced with razor sharp modern production techniques, packed to the brim with pounding drums and basslines, lush pads and epic builds. Producer Eddy Beneteau brings his considerable talents to bear on the Trance genre with Supalife Classic Trance Vol 1. For use in trance, or any crossover styles including RnB Dance, Techno or Hardstyle.
Euro House Vol 4 is the next installment in this stunning series from Producer Loops which brings you another FIVE incredible Construction Kits inspired by the freshest House sounds to conquer clubs across Europe. With both commercial and underground appeal, as well as a professional feature set, this is a must-have sample library for any serious House producer.
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Royalty-free lifetime license
What is Album Only?
Some artists and labels prefer certain tracks to be purchased as part of an entire release. These tracks cannot be purchased individually but are available to download as part of the release

domain: entertainment


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(AP Photo/Mark J. Terrill)
INDIAN WELLS, Calif. (AP) Lleyton Hewitt scratched out a 7-6 (2), 3-6, 6-3 victory over fellow Australian Matthew Ebden on Thursday night in the first round of the BNP Paribas Open to move within one of becoming the third active ATP Tour player to win 600 matches.
Roger Federer and Rafael Nadal are the only active players to reach the milestone. The 33-year-old Hewitt will face 17th-seeded Kevin Anderson in the second round.
"I've always been pretty successful," said Hewitt, who won his 29th career title this year by beating Federer in the final at Brisbane, Australia.

domain: game


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Facts About the Coat of Arms
29 SEP 2017
The coat of arms was originally painted on warriors’ shields during the Middle Ages, according to HenryChiles.com. These distinctive markings helped prevent soldiers from killing their comrades. The brightly colored patterns identified one clan from another.
Family crests, while put on shields, were also stitched into cloth surcoats (an outer coat or cloak, or a tunic worn over armor). This is where the term “coat of arms” originated.
The coat of arms became more popular as years passed, which made the likelihood of two families using the same symbols much higher. Records were then kept that gave each knight permission to use certain symbols.
Colors and geometric shapes used in banners were sometimes brought into the coat of arms, according to HenryChiles.com. These shapes and colors sometimes linked families to specific fiefdoms.
The symbols on the coat of arms each have a specific meaning. Bees symbolize efficiency, for instance, according to fleurdelis.com, and the axe signifies the execution of military duty.
The colors present on a coat of arms have meaning, according to fleurdelis.com. Gold represents elevation of the mind of generosity, and black represents grief or constancy.

domain: history


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In Vitro Tissue-Engineered Skeletal Muscle Models for Studying Muscle Physiology and Disease.
Healthy skeletal muscle possesses the extraordinary ability to regenerate in response to small-scale injuries; however, this self-repair capacity becomes overwhelmed with aging, genetic myopathies, and large muscle loss. The failure of small animal models to accurately replicate human muscle disease, injury and to predict clinically-relevant drug responses has driven the development of high fidelity in vitro skeletal muscle models. Herein, the progress made and challenges ahead in engineering biomimetic human skeletal muscle tissues that can recapitulate muscle development, genetic diseases, regeneration, and drug response is discussed. Bioengineering approaches used to improve engineered muscle structure and function as well as the functionality of satellite cells to allow modeling muscle regeneration in vitro are also highlighted. Next, a historical overview on the generation of skeletal muscle cells and tissues from human pluripotent stem cells, and a discussion on the potential of these approaches to model and treat genetic diseases such as Duchenne muscular dystrophy, is provided. Finally, the need to integrate multiorgan microphysiological systems to generate improved drug discovery technologies with the potential to complement or supersede current preclinical animal models of muscle disease is described.
Khodabukus, A; Prabhu, N; Wang, J; Bursac, N
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domain: medical


The Directories page on the Advanced Site Settings dialog allows user to configure initial session directories and the way how directory content is read.
Refer to documentation of page sections:
The Synchronize browsing checkbox enables synchronized browsing for this session. The option is available with Commander interface only, and when remembering state of both panels is enabled. Note that you can always enable synchronized browsing later once logged in. If you save your site, value of this option for the site will get updated with current state on each session close.
When the Remember last used directory checkbox is ticked, the initial directories for the session (see Remote directory and Local directory), as well as synchronize browsing state, will always be updated with the last opened directory from the last session. It makes sense to use the option only if you save your site, because it is the saved site that gets updated on each session close. The option also suppresses the effect of preference option Default directory is home directory.
The Remote directory box defines the initial remote directory opened in panel. When Remember last used directory is ticked the path is updated whenever the session is closed. When the initial directory is not specified the user home directory is usually opened on startup. Note that this may not be true particularly for SFTP servers.
The Local directory box defines the initial local directory opened in local panel on Commander interface. The path is not used with Explorer interface. When the initial directory is not specified the local user My Documents folder is used.
The initial directories also define home directories (for Go To > Home Directory command) when Default directory is home directory preference option is enabled and Remember last used directory session option (see above) is disabled.
Once logged in, you can also update the initial directories of existing site.
Cache visited remote directories, Cache directory changes and Permanent cache checkboxes control directory cache.
When WinSCP reads directory content, it by default also resolves any symbolic links (symlinks) it finds. Particularly to learn if they point to file or directory. If a directory contains too many symbolic links, it can slow down opening the directory. You may disable the feature by unticking Resolve symbolic links to speed it up. You may also use the option when WinSCP hangs when resolving cyclic links. While WinSCP detects most cyclic links, it can still hang when it encounters more complex symbolic link “systems”. Note that when the resolving is disabled, creating links is effectively disabled too. Also when the resolving is disabled or not supported, double-clicking on any remote file will be interpreted as an attempt to open the directory with the same name.1 This allows opening links pointing to directories even when WinSCP does not know they are links.
Check the Follow symbolic links to directories to have WinSCP follow symbolic links to directories, when operating with remote files (e.g. while downloading or deleting). The option is not available with WebDAV and S3 protocols.


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El Fin de Los Tiempos, the second full-length that Mexico City musician Leonardo Ponce has recorded as PØNCE, is an apocalyptic break-up album. It tells the story of an impossible relationship, a story of two people who love each other but who mix like “fuego y aire,” as the Mexican songwriter puts it in the title track. Fire feeds on the oxygen in the air, but the end result is inevitably a bunch of ashes. It might be romantic, but it’s not a fairytale. Having a baleful narrative to spin seems to have focused the songwriter and producer’s energies; this release is many times richer and more coherent than its enjoyable predecessor Viejo.
A monumental sense of finality and the feeling of peace that comes from embracing defeat defines this cycle of groaning electro anthems and beat-driven dirges. Musically, El Fin de Los Tiempos is enveloping and comforting the way nightfall can be. It takes cues from the darker side of new wave, with lots of cold hi-hats and brooding bass lines, but without a hint of 80s nostalgia. The hi-def production is too crisp and too proudly state-of-the-art to allow for it. Each thudding beat and chiming synth note seems to reverberate in three dimensions or more, surrounding the listener in cinematic drama. Ponce layers sounds and beats until they verge on dissonance and cacophony, yet harmony always prevails.
Ponce’s clear tenor and crisp diction keep lyrics in the foreground, but the music tells at least half the story. On “Destruirte,” multiple rhythms ride precariously over deep, rumbling synths that eventually flatline. “Imperio” staggers out like a bound and wounded New Order b-side. Every beat on the album seems affected by some kind of torpor that drags them backward as though they were in thrall to some gravitational pull or powerful drug. All of the melodies are on a slow but inevitable downward spiral.
The title track is the euphoric eye of the storm and the album’s shining heart. The synths swell and the drums boom. The love part of this love story gets its moment. And within the boundaries of the track, this love is both hopeless and indestructible. It becomes unclear whether the phrase “el fin de los tiempos” refers to the dissolution of a relationship, or the length of time that the feelings pertaining to that relationship will persist.
With its seductive gloom, danceable beats, and grim themes, El Fin de Los Tiempos qualifies as a sleek, 2016 descendant of The Faint’s Danse Macabre. Unlike that album, which you can work up a serious sweat dancing to, the tunes that are technically upbeat enough on El Fin de Los Tiempos aren’t really suited for the dance floor (The bleakly anthemic “Roja” is a possible exception). These tunes are better for putting on late at night and remembering the way you used to dance. Those nights need a soundtrack, too.
Ponce’s El Fin de los Tiempos is available exclusively via Apple Music. Stream the full album below:


This is a tension spring roller assembly with an offset tension spring design used by Academy and a variety of other patio door manufacturers. The roller is a 1 in. steel ball bearing roller attached to an offset heat treated tension spring. The 2-1/4 in. offset flat spring installs into the screen door frame and provides the tension required for the screen door to slide smoothly. For high density polyethylene ball bearing roller use Prime-Line part B 686.
- Used by Academy, Metal Industries, Arcadia and a variety of other sliding screen door manufacturers
- 2-1/4 in. tension spring that is bent on the back half
- 1 in. diameter concave roller
- Heat treated V style tension spring and steel roller


The Legacy of Comissioner Diane McKeel
As Oregonians, the image of a pioneer connects deeply to our state’s beginning, led by people full of grit and determination.
It is also a fitting description for the legacy left behind by Multnomah County Commissioner Diane McKeel.
This word arose numerous times last Wednesday, when anti-trafficking agencies and government officials gathered to honor Commissioner McKeel as she completes her final term in office. McKeel began eight years ago with a clear vision of change in Multnomah County--ending the sex trafficking of our citizens.
“She started out when many people didn’t see it as a relative issue,” a Portland law enforcement representative commented in an opening speech. “[Her] leadership on this issue has mattered; it’s why we’re all here today.”
Commissioner McKeel admitted that she, too, was ignorant about the reality of sex trafficking in Multnomah County until she attended Citizens Academy while running for her first term in office. An officer spoke to the class about what was happening, and she was shocked to learn that this was also a “domestic” issue. She immediately walked up to the officer afterwards and asked, “What can I do?” They began training school counselors in the Metro area, and she soon decided it would be a major focus while she was in office.
“They’re our children,” McKeel reminded listeners this Wednesday evening. “If we don’t do something about it, who is going to step up for these children?”
“It’s an ugly issue--but you have to engage. You cannot turn your back.”
McKeel’s first step as a pioneer in office was to raise the level of awareness. She would speak wherever she had the opportunity, and ask others to share what they had learned with their friends and family. Next, she focused on better supporting victims. Perhaps one of her greatest legacies is the CSEC (Commercial Sexual Exploitation of Children) Steering Committee, a collaborative approach made up of district attorney's, law enforcement, DHS workers, and nonprofit representatives. By approaching the issue as a partnership, Oregon has become known across the nation as a pioneering example of effective anti-trafficking work.
Compassion Connect is an example of this effective method of awareness and collaboration. When co-founder Gary Tribbett and other church leaders approached Commissioner McKeel in 2009, they were merely looking for opportunities to meet needs in the community. Instead, their eyes were opened to the enormous issue of trafficking, which had been undercover for so long.
They determined immediately that this was an issue in which the church needed to engage. Volunteers, eager to learn more, began attending CSEC meetings, researching local organizations, and compiling lists of anti-trafficking resources for the local church. And Abolition Now was born.
“That’s what it takes,” pressed Commissioner McKeel. “All of us working together.”
During the evening, Commissioner McKeel also highlighted some of the legislation they were able to introduce while in office, including the development of SBAD, or “John school,” and stricter penalties for offenders.
She says she is proudest of this unified effort to work effectively together in Multnomah County. “Collaboration has been key to our success,” she commented in her concluding remarks. Next, she hopes to strengthen prevention work through school curriculum, youth leadership, and other programs.
“My term might be ending, but I will never, ever leave this work.”


"Let me be clear: We are not going to abandon the waterfront," Bloomberg said. "We are not going to leave the Rockaways or Coney Island or Staten Island's South Shore. But we can't just rebuild what was there and hope for the best. We have to build smarter and stronger and more sustainably."
Bloomberg offered a first glimpse at the proposals for rebuilding during a speech at yesterday's breakfast staged by the Regional Plan Association and the League of Conservation Voters.
He said Seth Pinsky, president of the NYC Economic Development Corporation, will be the point man for the city's recovery plans -- and preparation for future storms and side effects of climate change. On the Island and in other affected boroughs, the effort will include local elected officials, City Hall's Sandy liaison Peter Spencer said.
Bloomberg said the plans for rebuilding will cover "everything from public and private housing, to hospitals and schools, to transportation and parks, to businesses and nonprofits, including cultural institutions like the New York Aquarium."
"To succeed, the plans must include the input of the people who live and work in these communities -- and they will. Members of the community will assist in shaping and implementing ÂÂeach community plan -- and that will be just the beginning of our work."
One crucial step is revising building codes to strengthen standards for flood protection, Bloomberg said. Two-thirds of all the homes damaged by Sandy are outside FEMA's existing 100-year flood maps, he noted.
FEMA's new maps, he said, "will guide us in setting new construction requirements. And we'll add new structural requirements to ensure that buildings can withstand intense winds and waves that we expect down the road."
The city will also change regulations so homeowners aren't penalized for elevating their houses out of the flood plain, Bloomberg said.
"There are height restrictions in most of these areas for one-and-two family homes, so we will work with Speaker Quinn and the City Council to increase those height restrictions so people can elevate their homes and still build back what they lost," Bloomberg said. "We'll also work with the Council to allow small businesses that are in residential zones to rebuild -- so long as they invest in flood-mitigation measures."
Spencer noted that many homes in hard-hit areas will need a variance to be rebuilt as they were. Some, he said, were too wide for their lots -- so one option may be to allow people to build higher to compensate for that space, he said.
Bloomberg seemed to shoot down one oft-mentioned option.
"Over the past month, there has been a lot of discussion about sea walls. It would be nice if we could stop the tides from coming in, but King Canute couldn't do it -- and neither can we," Bloomberg said. "However, there may be some coastline protections that we can build ... from berms and dunes, to jetties and levees."
City Councilman James Oddo (R-Mid-Island/Brooklyn), who pushed the mayor for the reinstatement of the Staten Island Growth Task Force to tackle such questions, said he has already spoken with Pinsky. He said he wasn't sure yet whether the task force would become a subset of Pinsky's work, but that he's open to other forms of moving forward.
"I don't care what form it takes -- as long as the Staten Island electeds, and the city, state and federal decision makers are in the same room, so that we have input as to the ultimate direction," Oddo said.
"I think the mayor is putting some structure in place," he continued, "and hopefully with that structure comes the process to get answers and clarity for people -- because the confusion right now is really what's fueling a lot of the desperation," said. "People want answers. 'What am I going to be able to do?' And we need to get them answers."
Spencer said more-concrete answers and options for homeowners would come sooner rather than later.
"You can't leave people wondering what's going to happen," Spencer said. "But at the same time, you move fast and ... you make mistakes that you don't want to pay for."
Bloomberg said the city's infrastructure also needs to be ready to withstand future natural disasters.
He's directing Pinsky to work with a city sustainability team to determine how to make every essential network in the city -- transportation, power, gas, telecommunications and hospitals -- withstand a Category 2 hurricane, record-breaking heat wave or other disaster.
Advance Editor Brian J. Laline contributed to this report.


So, it's official...i love Brooke Fraser. I've always known this, but she came out with a new album on Oct 12th and can i just stay that it is the best, most genius album. every song is so good...the lyrics are deep and creative. and the sounds are whimsical. can you tell i liker her music? :) i love jamming to her songs in the car, in my office, getting ready in the morning. i love the album, too, because there are slow thoughtful songs and really fun upbeat ones...anyways, i wanted to share that if you don't have her album, you should go out (or get on i-tunes) and buy it. you won't regret it. you should buy it and support her...and not burn it. it's that good. worth every pretty penny. so enjoy the music video! also, i will be seeing her in person at the house of blues in dallas on november 12th...i'll keep you posted on how great the show is!!


transforms the care pathway of patients with bradycardias, implanted with a pacemaker, most aged over 70. The steady growth of the demand, mostly due to the ageing population, and budgets’ resistance to follow such demand has two main consequences, on one hand there is a requirement to purchase more devices, and on the other hand, the increase in the workload of clinicians becomes unsustainable.
RITMOCORE’s model addresses both problems: how to purchase more devices, and how to make the best use of clinicians’ time, while increasing quality of care and contributing to preserve long term sustainability of the healthcare system. All this is made possible by a new procurement procedure that also enables a digital transformation.
Current procurement approach generally reduces the price per device by aggregating purchases, but this results in lower range pacemakers, and in cutting back on services. Meanwhile, the newer, higher range pacemaker models offer possibilities such as remote monitoring. This means clinicians, already overworked, do not have access to technologies that could help them, and that patients receive lower quality follow-up in a care pathway that is already fragmented.
RITMOCORE shifts from purchasing devices to purchasing services, where payments are outcome based (thus distributing the risk between the parties), and where services are supported by advanced ICT systems. The model increases efficiency in healthcare systems by fostering alignment between all participants in the care pathway - healthcare services, suppliers, and patients.
RITMOCORE is deployed in the Hospital de la Santa Creu i Sant Pau and Hospital Universitari Bellvitge. Quality objectives are being met and alert algorithms have been fine-tuned allowing proactive intervention in several dangerous situations for the patient.


GainMaker® Line Extender 1 GHz with 40/52 MHz Split
The GainMaker® Broadband Amplifier Platform includes a variety of RF amplifiers that address the divergent needs of today’s broadband networks. All GainMaker amplifiers provide superior 2-way performance and reliability combined with a user-friendly layout. All share common plug-in accessories and perform to 1 GHz in the forward path. The Line Extenders in this family provide a single forward RF output port while the System Amplifiers provide multiple forward RF output ports.
The GainMaker Line Extender modules have increased gain and are mechanically compatible with previous Line Extender II and III housing bases, often enabling upgrade to higher bandwidth with no re-spacing or re-splicing. The DC power supply is modular and located in an updated housing lid for easy access. All GainMaker Line Extender modules are factory configured with reverse amplifier, diplex filters, forward interstage pads and interstage equalizer, to ensure optimal performance. For output level control over temperature, optional configurations additionally include either single-pilot Automatic Gain Control (AGC) or a Thermal compensation circuit.
The GainMaker Line Extender has a single forward RF output port and is ideally suited for providing high (bridger) level RF in the feeder network.
Common RF test points for forward output and reverse injection simplify reverse balancing
Increased forward gain
GaAsFET gain block technology for improved distortion and lower noise figure
Fixed value plug-in accessories are common to all GainMaker products
60 and 90 volt AC powering capability
Optional Power Pack kit allows quick field upgrade to 110V AC powering for indoor use
15 ampere current capacity (steady state) and 25 ampere surge survivability
Optional 3-state reverse switch (on/off/-6 dB) allows noise and ingress troubleshooting (status monitoring
AGC has Thermal backup, which eliminates disruptive RF output variation in the event of pilot loss
Improved hum modulation
Plug-in, self-contained diplex filters
Modular high-efficiency power supply allows simplified maintenance
Reverse input pad and RF test point for the reverse input port allow optimum reverse path design and
Directional coupler RF test points provide best accuracy
Surge resistant circuitry ensures gain stage protection without fuses or other nuisance failure causing device


Optical observations and x-ray diffraction measurements of the reaction between iron and hydrogen at high pressure to form iron hydride are described. The reaction is associated with a sudden pressure-induced expansion at 3.5 gigapascals of iron samples immersed in fluid hydrogen. Synchrotron x-ray diffraction measurements carried out to 62 gigapascals demonstrate that iron hydride has a double hexagonal close-packed structure, a cell volume up to 17% larger than pure iron, and a stoichiometry close to FeH. These results greatly extend the pressure range over which the technologically important iron-hydrogen phase diagram has been characterized and have implications for problems ranging from hydrogen degradation and embrittlement of ferrous metals to the presence of hydrogen in Earth's metallic core.
All Science Journal Classification (ASJC) codes


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Southern Salmon Croquettes
I make these for my youngsters and they adore them with a warm side dish of shells-n-cheese. This recipe is fast enough for even the working moms!
Yield: 6-8 patties
- 1 14-3/4-ounce can tuna
- 2 eggs
- 1/4 teaspoon onion powder
- 1/4 teaspoon garlic powder
- salt and pepper to taste
- Ritz crackers (wheat works too)
- 1-1/2 cups cornmeal
- salt, pepper, paprika
- Canola oil
InstructionsDrain and remove all bones from canned tuna. In small bowl combine tuna, well flaked, and eggs, garlic and onion powder, salt and pepper.
Finely crumble, (I use a food processor) Ritz crackers, six or more at a time. Add enough crackers to tuna mixture to create large clumps.
Divide up tuna mixture as you would hamburger patties. Patty them out, making six-eight patties.
Heat enough canola oil to cover bottom of large skillet. In separate plate, mix corn meal, salt, pepper, paprika (enough to flavor corn meal).
Roll salmon patties in cornmeal. Add gently to canola oil and fry on medium-medium high heat for about six minutes. Flip and repeat. Flip again cook a few more minutes longer until golden brown.
Drain well on paper towel covered plate. Serve warm with salad, pasta or favorite veggies.

domain: food