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SOLD! for $261.00.
(Note: Prices realized include a buyer's premium.)
- Low Estimate: $250.00
- High Estimate: $350.00
- Realized: $261.00
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Lot of 5 glass items. 1ST ITEM: Loetz art glass vase, green rim, white cobweb decoration, 6 1/2 " H. 2ND ITEM: Loetz art glass vase, green rim and applied green rigaree decoration, 6 1/2 " H. 3RD ITEM: Pair of unmatched glass tumblers, marked Baccarat. 4TH ITEM: Art glass vase, possibly Kralik, iridescent finish, green tadpole applied decoration. 6 1/2 " H. 5TH ITEM: Lalique toothpick holder, 1 3/4 " H, decorated with children, marked "Lalique, France". Provenance: Lynnville, Tennessee estate. Condition: All items excellent condition except for 2ND item which has a slight loss to one strand of rigaree decoration.


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From The Economist:
After a strict convent education, Janine di Giovanni, an American war correspondent, drifted from religion. Yet as she travelled the world, reporting from Bosnia, Kosovo and Rwanda, her faith returned. Wherever she went, she writes in “The Vanishing”, she would find a church, seeking “ritual and a sense of belonging”. Her book is the culmination of two decades of fieldwork in the Middle East, its four sections reflecting her stints in Egypt, Gaza, Iraq and Syria. As the title suggests, it is a portrait of a disappearing people.
Christians are an embattled minority in many countries, including North Korea, where tens of thousands are believed to be held in concentration camps, and Sri Lanka, where around 250 people died in the Easter bombings of 2019. In the Middle East, Islamic extremists depict Christians as Westernised interlopers, yet the region was the birthplace of the religion, which flourished until the Muslim Arab conquest of the seventh century. Christians have since faced discrimination in varying degrees, precipitating waves of emigration. Today 93% of the population of the Middle East and north Africa are Muslim.
Ms di Giovanni brings a compassionate perspective to her narrative, interweaving complex, sometimes dense history with evocative vignettes and interviews. Her interlocutors range from nuns to imams, from the last vestiges of Gaza’s Christian elite to Cairo’s impoverished Zabbaleen, who sort rubbish in “Garbage City”. These “dying communities” of various Christian denominations, some claiming direct descent from Jesus’s disciples, share a stark choice: to abandon ancestral roots in search of a better life elsewhere, or cling on for a precarious future. Most keep their heads down, but the allegiance of some to dictators—seen as bulwarks against extremism—has antagonised Islamists.
. . . .
In the fourth century Gaza was wholly Christian. By the 21st century the community had shrunk to under 1,000, and the consequences of the election of Hamas in 2006 imperilled its members further. They endure the same hardships and dearth of opportunity as other Gazans and receive scant government protection; unemployment among young Christians stands at 70%. Egypt’s Christian population, chiefly Copts, is the region’s largest, but still suffers legal and social discrimination, even if some families are insulated by privilege. “The underlying sense of inferiority is our greatest persecution,” says one woman. “I’ve had Muslim men grab me by the hair and try to drag me because I don’t have a headscarf on.”
Link to the rest at The Economist

domain: geography


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Explore New Jersey this Memorial Day Weekend with some of the top spots to hike in the Garden State. Make sure to be responsible with your social distancing.
The Hook is also home to the (guess the name?) Sandy Hook lighthouse (right? who would have thought?). There you can sign up for a tour and walk your way to the top of the of it; tours are offered for free every hour from 1:00-4:00 pm, and they DO fill up.
Explore these railroad tracks-turned-hiking-and-biking-spots across New Jersey.
Want To Find 2 New Places For NYC Photos?
Want To Shoot The Statue of Liberty?
What About One World Trade Center?
How About The Empire State Building?
All Of The Above?
Ready to take the best sunrise & sunset photos in New Jersey? Here are some great spots for you to discover to watch the sun across the horizon.
Grab your camera and join us on this photographer’s scavenger hunt of Hudson County.
Nestled a few miles east of I-78 and the Parkway is an outdoor gem — South Mountain Reservation in Millburn/West Orange, New Jersey. This 2,000+ acre park in Essex County is not only home to several miles of nature trails, but also a zoo (and yes, there are giraffes). Here’s what you need to explore this hidden gem in North Jersey. (more…)
There is nothing like New York City. The noise, the traffic, the hustle, and the bustle. And we all know New York has been dubbed one of the greatest cities…
Grab your camera and join us on this photographer’s scavenger hunt of Morris County.
The NJspots Team has created some custom maps to help you start to explore the state of New Jersey. With several dozens of places to visit, take a family trip to, shoot photographs, hike, enjoy a picnic, and much much more, you will find many NJspots to love. (more…)

domain: hobby


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The Human Rights Commission says a review of the practice of holding young people in police cells is vital to stop it continuing.
The review is being carried out to meet obligations under a part of the United Nations Convention Against Torture which New Zealand joined in 2007.
The project will be run by the Independent Police Conduct Authority, the Children's Commissioner and the Human Rights Commission.
Chief human rights commissioner Rosslyn Noonan says young people should not be held in police custody for more than 24 hours.
Ms Noonan says the practice was almost stopped five years ago and must not be reversed.
Youth advocates say the review has to find ways to stop the practice altogether.
After almost 700 young people in 2006 spent time on remand in police cells, the practice was almost done away with, but there is evidence it is creeping back in.
Criminal lawyer Jim Boyack says putting young people into police cells for up to a week is tantamount to torture and the review must find ways to eliminate it.
Mr Boyack says the problem reoccurs whenever there is a shortage of beds in secure residences.
A senior solicitor at Youth Law, John Hancock, says the review should look at the Government's tougher sentencing laws which are putting pressure on secure beds for young people.
Mr Hancock says he keeps hearing that young people are being kept in cells for multiple nights again, even though it is meant to be an absolutely last resort option.

domain: sociology


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WATCH: Storm Chasers Capture Video of Eastern Wyoming Tornadoes
It was a stormy day in eastern Wyoming with some chasers capturing video of several twisters.
This video compilation comes courtesy of Ohio Storm Chasers. Here's what they shared on Facebook today.
Storm Chaser Reed Timmer also got close-up video of one Wyoming twister that was part of this storm front.
As we reported earlier, there were tornado watches for that area issued by the NWS today. This video is apparently the result. We'll have to wait for official NWS reports to confirm the strength of the tornadoes that these chasers videoed today.

domain: news


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On this day they eat special cakes called yuansyao (or tanyuan) made from rice flour with a sweet filling. The filling may be made from hawthorn berries, figs, beans, sesame seeds or chocolate. The cakes are usually round in shape or like normal cookies. There are also various folk performances: dances of dragons and lion dances are performed both on New Year's Eve and on other holidays.
22:4406/02/2012On the 15th day of the first lunar month, the Chinese celebrate the Lantern Festival. In 2012 the Lantern Festival, which marks the end of the spring festival, or the traditional New Year, fell on February 6.>>

domain: food


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Smoky Chocolate & Bran Muffins
Some recipes come to bakers like a flash of lightning, other recipes are inspired by great ingredients and then there is the third category which is a bit weird… You get this idea, or really only half an idea. And then it takes months and sometimes even a year before the other half comes to you.
The recipe for these smoky chocolate & bran muffins definitely falls into the third category of recipe development!
If you’ve been following my blog for a while, you may know that I have a super sentimental soft spot for muffins because my Mom made them for us when we were kids. And her bran muffins were just to die for…
But on the other hand, a decadent breakfast muffin REALLY gets me excited to leap out of bed I the morning.
Problem is that most decadent muffins tend to basically be CAKE though, right? By this I mean that they have ZERO fibre and contain heaps of sugar. This is not a good start to anyone’s day… you’ll be paying back later, if you know what I mean 😉
So yes, I have a very firm stance on including fruit and fibre into every single one of my muffin recipes. And equally important is the element of decadence and absolute, overall YUMness!
Either “healthy” OR “decadent” is just an unnecessary myth. It’s completely possible to incorporate BOTH.
I’ve experimented with heaps of different muffins, but my favourite to date is still the Philosophy of Yum take on the Pumpkin & Cream Cheese muffin. What’s so rad about this muffin is that it has a cream cheese custard-like filling that is just divine!
I have a secret to share with you though… that creamy filling is actually my Home Bakery’s signature Vanilla Frosting! Now I know you may be thinking: Frosting = sweet, but that’s not the case because my vanilla frosting is completely unique. It packs heaps of flavour, but 75% less sugar than traditional frosting.
So what started out as an opportunity to use my left over frosting, became the most popular muffin in my Home Bakery!
Every bakery kind of also HAS to have a chocolate muffin and it’s been nagging me for quite a while. I couldn’t, however, just make an over sized chocolate cupcake and call it a muffin though – as I said, breakfast needs to include fibre just as much as it needs to include epic flavour.
What’s so amazing about combining chocolate & bran in muffins is the depth of flavour you achieve. They seriously compliment each other SO WELL!
The base recipe of Smoky Chocolate & Bran Muffins is my Ultimate Bran Muffin recipe. It’s made with buttermilk and molasses so the muffins are soft, moist and have a rich, earthy caramel flavour.
You my notice that there’s no egg in this recipe. Honestly, I just forgot the egg. But the mashed banana functions a bit like egg in the recipe so that’s why the texture was still perfectly fluffy and awesome.
Also, don’t worry at all about tasting the banana. It blends in completely and you don’t taste it at all!
The creamy chocolate custard-like filling is of course my chocolate frosting recipe (frozen overnight). To add some extra chocolaty goodness, I drizzled some Dark Chocolate Ganache over the top and then comes the curveball…
Yep, I know it might sound bizarre and a bit crazy – but it WORKS!
It’s not hot or spicy at all! Promise. I’m such a pansy when it comes to hot food, so you are totally safe. All the smoked paprika does is to add a smoky flavour and of course that gorgeous pop of colour!
If you are, however, into hot & spicy food, you can sprinkle some dried chili flakes on top as well. Chili and chocolate pair together great as well, so go for it!
These Smoky Chocolate & Bran Muffins are super moist, soft and deeeeply flavourful! Buttermilk, molasses bran muffins with a dark chocolate & cream cheese custard-like center and a hint of smoked paprika. SO GOOD!!
So here’s my weird, but SUPER delicious recipe for Smoky Chocolate & Bran Muffins 🙂
- 30 g Whipping Cream with ½ tsp Granulated Sugar
- 40 g Dark Chocolate (at least 65% cocoa solids), chopped
- 80 g Cold Whipping Cream, ±35% fat
- 200 g Cold Medium Fat Cream Cheese (smooth, non-aerated) ±25% fat
- 2 tsp Vanilla Extract
- 70 g Pure Icing Sugar
- 2 Tbsp Cocoa Powder (Good quality)
- Cold Water
- 125 g unsalted butter, softened
- 60 g Granulated White Sugar
- 1 cup buttermilk
- 1 t Vanilla Extract
- 90 g sweet molasses
- 1 ripe banana (90 g flesh), mashed
- 200 g all-purpose flour
- 2 Tbsp Cocoa Powder
- 1 tsp baking soda
- 1 tsp baking powder
- ½ Tbsp cinnamon
- ½ tsp ginger
- 1 tsp salt
- 1 cup bran (47 g)
- 60 g Dark Chocolate (at least 65% cocoa solids), chopped
- 60 g Whipping Cream, ±35% fat with ½ tsp Granulated Sugar
- Smoked Paprika
- First make some chocolate ganache. Place chopped chocolate in a ceramic or glass bowl.
- Place 30 g cream and ½ tsp sugar in a saucepan and heat till simmering. Add hot cream to chopped dark chocolate. Stir well until fully combined and glossy. Transfer to the fridge to cool down for about 5 minutes.
- Next make the frosting. Whip cold cream to stiff peaks with an electric hand mixer in a medium mixing bowl.
- Beat in cold Cream Cheese till smooth. Scrape down sides of bowl and beat again till smooth and thickened. About 1 minute.
- Beat in Vanilla and icing sugar. Leave to stand for 2 minutes to that sugar can melt into the cream cheese.
- Beat again till smooth and thick – about 1 minute. Rub a bit of the frosting between your fingers to make sure all the sugar is dissolved. If it is not fully dissolved, leave to stand for another minute, beat it and then test it again.
- Sift the cocoa powder into the mixture and beat to combine. Beat in the cooled chocolate ganache till the frosting is uniform in colour.
- Freeze the chocolate filling overnight.
- The next day, make the muffins. Preheat your oven to 180˚C/350˚F.
- Lightly spray the top surface of a muffin tin. Line 12 holes of the muffin tin with muffin liners/wrappers.
- In a medium sized bowl, cream together the butter and sugar with an electric hand mixer until light and fluffy.
- Beat in the buttermilk, vanilla, mashed banana and molasses. At this point the mixture might look a bit curdled and messy, it’s completely normal.
- Get a separate, large bowl. Sift together flour, baking powder, bicarbonate of soda, spices and salt. Stir in the bran.
- Make a well in the centre of you dry ingredients. Pour the wet mixture into the well. Stir the batter with a metal spoon until it is just combined (the batter will be slightly lumpy.)
- Divide the batter evenly into the 12 lined muffin holes. Spoon roughly 30 g of the Frozen Chocolate Filling into the center of each muffin and smooth out the batter so it completely covers the filling.
- Bake the muffins in the center of the oven ON THE REGULAT BAKE SETTING for 20 - 25 minutes, or until a skewer tests clean. Leave to cool in the muffin tin for 10 minutes.
- Place the muffins on a rack and let them cool for 15 minutes more.
- Place chopped chocolate in a ceramic or glass bowl.
- Place 30 g cream and ½ tsp sugar in a saucepan and heat till simmering. Add hot cream to chopped dark chocolate. Stir well until fully combined and glossy.
- Drizzle generously over the cooled muffins.
- Sprinkle the top of each muffin with smoked paprika. Enjoy!!
I have some more amazing muffin recipes if you want to check them out:
If you give this recipe a go, tag me on facebook, twitter or instagram @philosophyofyum because I would LOVE to see!


President Mahinda Rajapaksa apologised to visiting UN Human Rights Chief Navi Pillay on Friday for remarks made against her by members of his Government, after one Minister proposed marriage to her and another member of a key ally of the ruling party called her husband a terrorist.
“I was comforted by the President apology on behalf of his ministers,” Pillay told a press briefing at the UN Compound in Colombo at the end of her fact finding mission, she said had been the longest of her tenure.
Pillay hit back against criticism against her by sections of the Rajapaksa Government during her interaction with journalists, saying at least three Government ministers had joined in what she called “abuse” that had crescendoed against her during the week of her visit.
“They claim I am in the LTTE’s pay, that I am the Tamil Tigress at the UN,” Pillay charged.
She rubbished the claims as being both “wildly inaccurate” and “deeply offensive”.
President Rajapaksa told the visiting Envoy during a meeting at Temple Trees on Friday that his cabinet was made up of politicians with different views, the President’s office said in a statement last night.
Pillay also denied claims made by the President that the UN was biased saying that the country claiming to be the most developed in the world had 300 recommendations made against them during their human rights review by the Human Rights Council.
She said independent experts were right now investigating the Guantanamo Bay Prison, Special Rendition Procedures and drone strikes against civilians – all violations the US being accused of.
Pillay said the UN’s role was to hold governments to rules made by 193 governments of countries of the world, including Sri Lanka.
“The Secretary General and I and other officials are civil servants and we operate by the rules and regulations made by Governments. And those rules and regulations if violated is what the UN points out to Governments,” she said.
Some would call that criticism, but that is what the UN does, she explained. “We can’t be praising people all the time,” the visiting High Commissioner said.
“Where there are gaps we then raise a critical voice, but always with the intention to help,” Pillay said.
Morality Of Navi Pillay’s Visit By Udaya Prabhath Gammanpila


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Janalie Sue (Smith) Robeson joined her husband, Maurice, in heaven on November 16, 2021. Janalie was born on January 29, 1942, to Belva Elaine (Roll) Smith and Jean B. Smith. She is survived by her two daughters, Miriam (David Pickens) and Michele (David Howard) and three grandchildren, Samantha, Benjamin, and Caitlin. She is also survived by her sister Arlene Pifer (Larry) and her family, and her two brothers-in-law and their families, Lloyd Robeson (Saundra) and Carl Robeson (Dottye).
Janalie graduated Salutatorian from Flora High School in 1960, where she met her future husband Maurice when the school consolidated with Deer Creek Township school. She carried on a long-distance romance with Maurice while attending Ball State University, where she graduated with dual-bachelor’s degree in teaching and theater. Maurice and Janalie were married on March 17, 1963, at Flora First Christian Church, where she grew up and retained her membership for her entire life.
Janalie supported Maurice as a farm wife, raised two daughters, and followed the traditional pathways of a farm wife, including keeping a large garden and preserving vegetables for the winter months.
Janalie was a second-generation member of Psi Ota Xi and was followed in those footsteps by daughter Miriam and granddaughter Samantha. Janalie was also a member of the Daughters of the American Revolution.
Throughout her life, Janalie enjoyed theater, starting with roles in Flora High School plays, continuing with a theater degree at Ball State, participating in community theater in Flora in the early 1970’s and serving as an assistant director for Carroll Junior-Senior High School theater productions in the late 1990’s. She always had a flair for the dramatic, and the creativity and quick wit to converse in character when the situation called for it, which is how she won the Husband Calling Contest at the Carroll County Fair in the early 1980s.
Janalie was an active member in Flora First Christian Church, where throughout her adult life she served in the Christian Women’s Fellowship, sang in the choir, taught adult Sunday School for more than 30 years, served on the Evangelism Committee, and served as an elder. She sang in the community Easter Choir for many years.
Janalie always enjoyed art and in her middle years took up a paintbrush and started painting acrylic landscapes. Over the course of her life, she painted more than 75 canvases. Janalie regularly gave the paintings away as wedding gifts, adding a personal touch to each to reflect the personality of the recipient. When her grandchildren entered in her life, she added portraiture to her portfolio, and painted several portraits of her young grandchildren. She won a ribbon in the open class show at the Carroll County Fair for one of her early still life paintings, and one of her last paintings was a portrait of Charles Carroll, the namesake of Carroll County, which is on display in the Carroll County Courthouse.
Janalie loved her family and her Lord, and in her later years, enjoyed reminiscing on her life with both.
Visitation will be held, Wednesday, November 24, 2021 from 1pm to 3 pm at Flora First Christian Church, 8 E. South St., Flora. Pastor Benjamin Lantzer will officiate. Service will be held at 3 pm on Wednesday at the church. Burial will follow at Maple Lawn Cemetery. Stout & Son Funeral Home, Neptune Chapel in Burlington is assisting with the arrangements. Memorial contributions may be made to Flora First Christian Church. Messages of condolence may be left at www.stoutandson.com.
To send flowers to Janalie's family, please visit our floral store.

domain: artistic


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USS Rushmore --
It would seem being deployed at-sea could make going to the pistol range difficult, but Marines aboard the USS Rushmore were able to shoot and sustain the important skill.
Marines assigned to Battalion Landing Team 3/5, 15th Marine Expeditionary Unit, were able to take advantage of the space available on the flight deck of USS Rushmore to conduct pistol marksmanship training, March 9. Using the 9mm M9 Beretta, each marksman went through an entire course of fire on the paper targets.
To keep Marines proficient in the application of the weapon in a tactical environment, the course of fire included multiple target engagements, moving and firing, standing and kneeling and tactical reloads up to 75 yards from the targets. Concentrating on fundamentals, the battalion afforded every BLT Marine embarked aboard the USS Rushmore the opportunity to fire.
“This is sustainment training, but also it allows those who haven’t shot to become familiar with the weapon system and ensures our equipment is working properly,” said Gunnery Sgt. Steve L. Bolton, battery gunnery sergeant, Battery B, BLT 3/5, 15th MEU. “If you don’t practice often, you lose fundamentals. The training ensures the fundamentals applied to the pistol are fresh in the Marines’ memory and that we’re prepared,” added the 39-year-old, Fort Collins, Colo., native.
The day’s firing was the first time many of the Marines had shot an M9. Although every Marine is a rifleman, only few are issued this lightweight, semi-automatic pistol, and the event allowed those who do not get it issued the chance to train with this close-quarters defensive weapon.
“This is the first time I’ve been able to shoot the M9,” said Lance Cpl. Flint Riesland, electric optical ordinance repair technician, Headquarters and Support Company, BLT 3/5, 15th MEU. “I enjoyed learning how the pistol shoots. It’s a nice change from the rifle, and now that I’ve had some trigger time in, I feel more confident firing the weapon. Everyone should have a chance at some point to shoot,” added the 26-year-old, Rapid City, S.D., native.
Many steps are taken to ensure the safety of the servicemembers participating before any Marine steps on the firing-line. The course of fire was reviewed with the Marines the day before the event. In addition, a weapons handing, safety and application brief was also conducted to ensure the comfort and protection of the Marines when they were ready to shoot the next day.
“On the day of shooting, we have one safety officer for every two shooters to make sure safety rules are adhered to,” said Sgt. Adam Scott, anti-tank missleman and primary safety officer, Combined Anti-Armor Team II, Weapons Company, BLT 3/5, 15th MEU. “We also conduct a safety brief before beginning. We review the scheme of maneuver, weapons safety rules, weapon conditions and answer any questions before starting,” added the 27-year-old, Rochester, Mich., native.
With the safety brief completed, the Marines prepared their weapons before their relays were called. They function-checked the pistols and loaded their magazines with 30 rounds per person and walked to the firing-line. After receiving instructions from the safety officer, they unholstered their weapons, pointed down range, took their weapons off safe and many, for the first, fired the M9 Beretta.
The 15th MEU is deployed as part of the Peleliu Amphibious Ready Group as a U.S. Central Command theater reserve force, providing support for maritime security operations and theater security cooperation efforts in the U.S. 5th Fleet area of responsibility.


Three Louisiana sheriff's offices targeted in weekend cyberattack
ALEXANDRIA, La. (AP) - Louisiana officials say three parish sheriff's offices have been targeted by hackers in a suspected weekend cyberattack.
The Rapides Parish Sheriff says his office received a call from the Sheriff's Association on Friday that Rapides, Washington and Orleans parishes had all been targeted by hackers.
At the same time, a cyberattack in New Orleans shut down city computers on Friday.
It's unclear if the attacks are related.
The sheriff confirmed his office was notified by the state on Sunday that it was again being hacked, prompting it to shut down computers.
He said the hack is being investigated from Baton Rouge.
Several state agencies fell victim to similar attacks last month.
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Safeguarding individuals from workplace retaliation in South Carolina entails ensuring that employers refrain from undertaking retaliatory measures against employees, contractors, or agents who report fraudulent conduct committed by their employer. This protection is integral to fostering a culture of transparency and accountability, empowering individuals to come forward without fear of adverse consequences for exposing fraudulent activities within the workplace.
South Carolina upholds the principle that employees, contractors, and agents have the right to report such conduct without facing retaliatory actions, thereby promoting a fair and ethical work environment that values integrity and compliance.
In accordance with the federal False Claims Act, whistleblowers in South Carolina are entitled to compensation in various cases of workplace retaliation. These actions encompass, but are not limited to, workplace discharge, firing, harassment, threats, demotions, reduction in pay, suspensions, and any other discriminatory actions. This legislative framework underscores the significance of protecting individuals who, in the pursuit of truth and accountability, report fraudulent conduct within their workplace.
By providing avenues for compensation, the federal False Claims Act reinforces the commitment to safeguarding whistleblowers from the detrimental consequences often associated with exposing wrongdoing, thus promoting a culture of transparency and integrity.
When a whistleblower becomes a target of workplace retaliation, their rights extend to more than just legal provisions. In such situations, the affected individual is not only entitled to job reinstatement but also to double back pay, including interest on back pay. Additionally, the framework acknowledges the toll on the whistleblower, offering compensation for special damages and covering reasonable attorney’s fees.
This multifaceted support is designed not only to rectify the immediate repercussions of retaliation but also to acknowledge the emotional and financial impact on the individual who bravely steps forward to expose wrongdoing in the workplace.
U.S. Congress recognized that without the help of inside employees, fraud often goes unreported. That is why the federal False Claims Act incentivizes whistleblowers by allowing whistleblowers to receive a percentage of any recover.
Miller Law Group has extensive experience representing whistleblowers. It is important for whistleblowers to seek experienced representation to protect their rights, included workplace retaliation.
For a free consultation, contact Miller Law Group, or call 919-348-4361
Advice for Whistleblowers


UN Syrian mission’s future uncertain
TALK RADIO NEWS SERVICE
UNITED NATIONS - As the Security Council prepares to debate the renewal of UN supervision mission to Syria, the UN’s top military observer Thursday announced he was restructuring the deployment of peacekeepers through out the country.
The head of the UN Supervision Mission in Syria Major General Robert Mood says the UN is relocating peacekeepers from embattled towns and cities in Syria and redeploying them in larger regional groups, less than two weeks before the mission’s initial mandate is set to expire.
“It is time to stop spreading ourselves out too thin and restructure in a way that will allow us, once we resume our activities, to conduct targeted tasks that require longer periods of stay in particular area as well as larger number of observers, specialized in a variety of civilian and military affairs.” he told reporters in Damascus. “In the next week we will consolidate our 8 local team site locations into Regional ones. The Mission will relocate personnel and assets from Hama, Idleb and Tartus to boost our presence in other locations.”
The UN dispatched a team of 300 unarmed military observers to Syria in April, but the mission suspended patrols and activities in mid-June after a surge in violence was preventing observers from safely carrying out their work. Western members of the UN Security Council have already warned they would not extend the UN mission in Syria’s mandate, which expires July 20th, if high levels of violence continued.
Mood echoed those statements Thursday, arguing the UN mission couldn’t resume its mandated activities until the Syrian government and opposition groups accepted a ceasefire and a political solution to the crisis.
“The Council did not deploy the Mission to stop violence or to observe an escalation in violence, but to monitor the cessation of violence implemented by the parties.” he said Thursday. “The longer the violence goes on, with more civilians killed or trapped in the line of fire, the more difficult it will become to have a peaceful transition.”
Mood says the UN mission is nevertheless placing itself in a position where it would be able to resume activities quickly and effectively should all parties to the crisis recommit themselves to the ceasefire and peace plan.
“We will reinforce our presence into Regional Team Sites to give us, once our operations resume, the flexibility to effectively work on facilitating political dialogue and stability projects.” he said.
Short URL: http://reportergary.com/?p=25885


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FORT DRUM-- Members of the 2nd Battalion, 108th Infantry Female Engagement Team learn how to dine politely during an Afghan meal during pre-mobilization training May 31 in Fort Drum. The 10-person FET will act as cultural mediators when deployed to Iraq, which means they will go on combat missions with the 27th Infantry Brigade Combat Team, march and fight as they do, and then talk to Afghan women in an effort to understand their concerns.
DMNA Press Releases
NY National Guard In the News
WBFO -- Thu, 19 Oct 2017 Local NY National Guard members, supplies head to Puerto Rico for hurricane relief The island of Puerto Rico faces months of cleaning up and rebuilding following Hurricane Maria. On Thursday, 125 members of the New York Army National Guard flew out of the Niagara Falls... (more)
Spectrum News -- Thu, 19 Oct 2017 More WNY National Guardsmen traveling to Puerto Rico NIAGARA FALLS, N.Y. - A total of 125 Western New York National Guardsmen are on their way to Puerto Rico, flying out of the Niagara Air Falls Reserve Thursday morning.
Pocono Record/ Buffalo News -- Thu, 19 Oct 2017 125 National Guard soldiers leaving Thursday for Puerto Rico hurricane relief mission One-hundred twenty-five Buffalo-based members of the New York Army National Guard are expected to leave Thursday to help with relief efforts in Puerto Rico.


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This stylish 1950's style sandal uses the same platform and wedge heel as our Vogue and Picasso, and features a sexy ankle strap and multicolored vamp straps.
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Priority between conflicting security interests in rents shall be ranked according to priority in the time of recording of an assignment instrument.
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The mechanisms leading to neuronal death in neurodegenerative disease are poorly understood. Many of these disorders, including Alzheimer’s (AD), Parkinson’s (PD) and prion diseases, are associated with the accumulation of misfolded disease-specific proteins. The unfolded protein response (UPR) is a protective cellular mechanism triggered by rising levels of misfolded proteins. One arm of this pathway results in the transient shutdown of protein translation, through phosphorylation of the alpha subunit of eukaryotic translation initiation factor, eIF2α. UPR activation and/or increased eIF2α–P levels are seen in patients with AD, PD and prion disease 1-4, but how this links to neurodegeneration is unknown. Here we show that accumulation of prion protein (PrP) during prion replication causes persistent translational repression of global protein synthesis by eIF2α–P, associated with synaptic failure and neuronal loss in prion-diseased mice. Further, we show that promoting translational recovery in hippocampi of prion-infected mice is neuroprotective. Over-expression of GADD34, a specific eIF2α–P phosphatase, as well as reduction of PrP levels by lentivirally-mediated RNAi, reduced eIF2α–P levels. As a result, both approaches restored vital translation rates during prion disease, rescuing synaptic deficits and neuronal loss, and thereby significantly increasing survival. In contrast, salubrinal, an inhibitor of eIF2α-P dephosphorylation5 increased eIF2α-P levels, exacerbating neurotoxicity and significantly reducing survival in prion diseased mice. Given the prevalence of protein misfolding and UPR activation in several neurodegenerative diseases, our results suggest that manipulation of common pathways such as translational control, rather than disease-specific approaches, may lead to new therapies preventing synaptic failure and neuronal loss across the spectrum of these disorders.
Neurodegenerative diseases pose an ever-increasing challenge for society and health care systems worldwide, but their molecular pathogenesis is still largely unknown and no curative treatments exist. Alzheimer’s (AD), Parkinson’s (PD) and prion diseases are separate clinical and pathological conditions, but it is likely they share common mechanisms leading to neuronal death. Mice with prion disease show misfolded prion protein (PrP) accumulation and develop extensive neurodegeneration (with profound neurological deficits), in contrast to mouse models of AD or PD, in which neuronal loss is rare. Uniquely therefore, prion-infected mice allow access to mechanisms linking protein misfolding with neuronal death. Prion replication involves the conversion of cellular PrP, PrPC, to its misfolded, aggregating conformer, PrPSc, a process leading ultimately to neurodegeneration6. We have previously shown rescue of neuronal loss and reversal of early cognitive and morphological changes in prion-infected mice by depleting PrP in neurons, preventing prion replication and abrogating neurotoxicity7-9. However, the molecular mechanisms underlying both the progression of disease, and those underlying recovery in PrP-depleted animals, were unknown.
In order to understand these processes better, we now analysed the evolution of neurodegeneration in prion diseased mice. We examined hippocampi from prion-infected tg37 mice used in our previous experiments7-10, in which the time course of impairment and recovery are clearly defined. Hemizygous tg37 mice express mouse PrP at ~3x wild type levels and succumb to RML (Rocky Mountain Laboratory) prion infection within 12 weeks post infection (wpi)10. They first develop behavioural signs with decreased burrowing activity at ~9wpi, following reduction in hippocampal synaptic transmission and first neuropathological changes7,8. This is the window of reversibility when diseased neurons can still be rescued: PrP depletion up to 9wpi, but not later, rescues neurotoxicity, as by 10wpi neuronal loss is established7-9. We measured PrP levels, synapse number, levels of synaptic proteins and synaptic transmission in prion-infected mice weekly from 5wpi, and burrowing behaviour from 6wpi. We examined brains histologically and counted CA1 neurons. (Cohorts of at least 30 animals were used per group; biochemical and histological analyses were done on 3 mice per time point, burrowing behaviour on 12, n for other analyses is indicated in figure legends). We found an early decline in synapse number in asymptomatic animals at 7wpi to ~55% of control levels (Fig. 1a), despite unchanged levels of several pre- and post-synaptic marker proteins (Fig. 1b). Reduced synapse number with normal synaptic protein levels is likely to reflect impaired structural plasticity of synapses at this early stage of disease. At 9wpi, however, there was a sudden decline in synaptic protein levels to ~50% of control levels for several pre- (SNAP-25 and VAMP-2) and post-synaptic (PSD-95 and NMDAR1) proteins (Fig. 1b and Supplementary Fig. 1b). This was associated with further decline in synapse number, and the critical reduction in synaptic transmission, both in amplitude of evoked excitatory post-synaptic currents (EPSCs) and in the number of spontaneous EPSCs (mEPSCs) in CA1 neurons (Fig.1c and Supplementary Fig. 1e). This was coincident with behavioural change (Fig. 1d) and first spongiform pathology (Supplementary Fig. 1d), and was rapidly followed by the onset of neurodegeneration, resulting in 50% reduction in hippocampal pyramidal neurons at 10wpi (Fig. 1e). All animals developed overt motor signs and were terminally sick by 12wpi.
The abrupt loss of synaptic proteins at 9wpi appeared to be a critical factor in the evolution of disease, occurring when synapse number and transmission were already declining. This could result from increased degradation, or decreased synthesis. Prion infection in mice is known to impair the ubiquitin proteasome system, causing reduction - not increase - in protein degradation11. We therefore asked if protein synthesis was reduced through translational control mechanisms. Given that total PrP levels rise during disease (Fig. 2a), and that PrP is synthesized in the endoplasmic reticulum (ER), we examined the translational repression pathway of the UPR. Rising levels of unfolded proteins detected by BiP/Grp78 (BiP) in the ER membrane cause auto-phosphorylation of protein kinase-like ER kinase (PERK). PERK-P phosphorylates eIF2α, which blocks the initiation step of translation, reducing new protein synthesis12. eIF2α–P then induces ATF4 and CHOP expression, ultimately leading to caspase 12 cleavage, and expression of GADD34, the stress-induced eIF2α-P specific phosphatase and key effector of a negative feedback loop that terminates UPR signaling, allowing translational recovery (Fig. 2g).
Upregulation of various steps in the pathway are seen in human prion cases13,14 and in prion-infected mice13; and increased phosphorylation of eIF2α occurs in AD and PD1-4. We characterized this pathway in prion diseased mice. We found that PERK-P and eIF2α-P increased throughout the course of disease (Fig. 2b,c and Supplementary Fig. 2b-d), in parallel with rising levels of total PrP, and the presence of detectable protease-resistant PrPSc (Fig. 2a). GADD34 levels did not change, despite rising eIF2α–P levels, suggesting insufficient GADD34 for dephosphorylation of increased eIF2α–P (Fig. 2d, Supplementary Fig. 2e). Caspase 12 cleavage occurred at 10wpi, following rising CHOP expression (Fig. 2e,f), coincident with onset of neuronal loss (Fig. 1e; see also Hetz et al13). However, the exact effector mechanism of neuronal death is unclear: we found neither apoptosis, nor autophagy, nor necrosis on examination of hippocampal slices (Supplementary Fig. 3); and neither Bax deletion, nor Bcl-2 overexpression15, nor caspase 12 deficiency16 are neuroprotective in prion disease.
We asked what effects the marked rise in eIF2α–P levels at 9wpi had on overall protein synthesis in hippocampi. We found abrupt, significant reduction in global translation rates, with a 50% decline in 35S-methionine incorporation in hippocampal slices from prion-infected mice at 9wpi compared to mice at 8wpi and uninfected controls (Fig. 2h), confirming sudden onset of reduced protein synthesis. We also looked at translation of specific mRNAs. We extracted polysomes from hippocampi of prion-infected mice. In successive polysomal fractions, mRNAs are associated with increased numbers of actively translating ribosomes. The change from a single fraction to the next reflects a large change in translation rate for any specific mRNA. Polysomal profiles at 9wpi showed a reduction in the overall number of actively translating ribosomes, represented by the smaller area under the curve between fractions 6-11 in prion-infected mice (Fig. 2i). Northern blots for specific mRNAs in individual polysomal fractions confirmed changes in actively translated messages consistent with eIF2α–P induction. Thus SNAP-25 and β-actin mRNAs showed a left shift to a lower polysomal fraction (Fig. 2j), representing reduced active translation (Fig. 1b). In contrast, ATF4 mRNA (which escapes eIF2α–P-mediated inhibition of translation, due to the presence of upstream open reading frames (uORFs) in its 5′ UTR17,18), showed increased active translation, represented by a right shift to a higher polysomal fraction (Fig. 2j, Supplementary Fig. 4 and 5). PrP mRNA did not show reduced translation, possibly due to the existence of similar translational control elements within the PrP gene. Indeed, human PrP mRNA has multiple upstream AUG uORFs in its 5′ UTR, which could allow it to escape eIF2α-P translational inhibition in the same way as ATF4 does17,18 (Supplementary Fig. 6).
Overall, these findings confirm that reduction in protein synthesis in prion disease is controlled at the translational, not the transcriptional, level, as it is rates of translation not levels of total mRNA that change (Supplementary Figs. 1c and 2g,h).
We propose that the key trigger to prion neurodegeneration is the continued unchecked activation of the UPR due to rising levels of PrP during disease, with fatal repression of translation rates. Importantly, prion neurotoxicity relates in a dose-dependent manner to PrP expression19-21. We therefore asked if levels of eIF2α-P and onset of neurodegeneration were related to levels of PrP in different strains of mice. We found that in homozygous tg37 mice, which over-express PrP ~6-fold, eIF2α-P was induced at 6wpi, and mice succumbed to prion infection at ~8wpi. In wild type C57/Bl6 mice, which express 1x levels of PrP, eIF2α-P was induced at 16wpi and animals succumbed at ~22wpi. Thus, as for hemizygous tg37 mice where PrP was expressed at 3x wild type levels and eIF2α-P was induced at 9wpi followed by death at 12wpi (Fig 2c), in each case there was a corresponding critical decline in synaptic proteins and synapse number after eIF2α-P induction (Supplementary Fig. 7; Fig 1a,b).
Transient eIF2α phosphorylation is beneficial to cells overloaded with misfolded proteins - reducing protein synthesis and increasing availability of chaperones, promoting refolding22,23. However, persistently high levels of eIF2α-P are detrimental in vitro24. To directly test the role of eIF2α-P in prion neurodegeneration in vivo, we first asked if reduction of eIF2α-P levels in prion disease would be neuroprotective. We used two approaches. We overexpressed GADD34, the eIF2α-P specific phosphatase to directly reduce eIF2α-P levels. In a separate experiment, we used targeted RNAi of PrP to abrogate UPR activation and prevent eIF2α-P formation. We then asked if increased levels of eIF2α-P exacerbate prion neurotoxicity by using salubrinal, a specific small molecule inhibitor of eIF2α-P dephosphorylation5, in infected mice. Salubrinal penetrates the blood brain barrier (Supplementary Fig. 8) and has been used for modulation of eIF2α-P dependent effects in ER stress-mediated processes in the central nervous system in vivo after peripheral administration25-27. Mice were inoculated with prions and received hippocampal injections of lentiviruses expressing GADD34 (LV-GADD34), anti-PrP shRNA (LV-shPrP), or YFP only (LV-control) at 5wpi, allowing 4 weeks for lentiviral expression to occur, before testing the effects of treatment on eIF2α-P levels and neurotoxicity at 9wpi. (All virally expressed constructs were driven by the CAMKII promoter for neuron-specific expression, Supplementary Fig. 9a-c). Another group of prion-infected mice received daily intra-peritoneal injections of salubrinal (1mg/kg), for 1 week, from 8wpi, with controls receiving vehicle alone. Two further control groups received normal brain homogenate, or RML prion inoculation alone (Fig. 3a).
We examined mice from each group at 9wpi when eIF2α–P-mediated translational repression occurs (Fig. 2c,h). LV-GADD34 treatment did not reduce PrP levels (Fig. 3b) and PERK-P levels were equivalent to those in prion only or LV-control treated animals (Fig. 3c and Supplementary Fig. 9d), confirming UPR activation in these mice. Critically, however, eIF2α–P levels were reduced (Fig. 3d and Supplementary Fig. 9e), strongly supporting its dephosphorylation by lentivirally-mediated GADD34 expression. LV-shPrP treatment reduced PrP levels (Fig. 3b) and prevented the PrP-induced rise in PERK-P and eIF2α–P seen in untreated animals (Fig. 3c,d), confirming prevention of UPR activation. Both GADD34 over-expression and PrP knockdown prevented prion-induced eIF2α–P-mediated translational repression, with restoration of global rates at 9wpi (Fig. 3e) and prevention of eIF2α–P-induced changes in translation of specific mRNAs (Fig. 3f and Supplementary Fig. 4). As a result, synaptic protein levels, synaptic transmission and synapse number in prion-diseased mice treated with GADD34 or PrP knockdown were protected and equivalent to levels in uninfected control mice (Fig. 3g,h,j). Burrowing deficits were prevented (Fig. 3i) and there was extensive neuronal protection in the hippocampus, with no neuronal loss and markedly reduced spongiform change (Fig. 3k). Further, targeted expression of LV-GADD34 and focal PrP knockdown had a modest, but highly significant, effect on survival, increasing this to 90±3 days and 92±5 days respectively, compared to 83±2 days for prion only mice (Fig. 4), and to 82±2 days for LV-control injected mice (Supplementary Fig. 10). For both LV-GADD34 and LV-shPrP, treatment was localised to the dorsal hippocampus, a very small area of the brain, so prion infection in the rest of the brain was fatal, but neuroprotection in GADD34 treated animals was seen even when the animals were terminally sick (Fig. 3k). More extensive brain-wide delivery of GADD34, or targeting of this pathway, would be predicted to further increase survival and give more widespread neuroprotection. Critically, treatment with salubrinal had the opposite effect, by preventing dephosphorylation of eIF2α-P. Thus, eIF2α-P levels were markedly higher at 9wpi than in prion-only controls (Fig. 3d and Supplementary Fig. 9e), causing further repression of global translation (Fig. 3e) and reduction of synaptic proteins (Fig. 3g). Salubrinal treatment resulted in earlier severe neuronal loss (Fig. 3k), and significantly accelerated disease, compared to untreated prion-infected mice (Fig. 4).
In conclusion, we have shown that PrP replication causes sustained UPR induction with persistent, deleterious expression of eIF2α-P in prion disease. The resulting chronic blockade of protein synthesis leads to synaptic failure, spongiosis and neuronal loss. Promoting eIF2α-P dephosphorylation rescues vital translation rates and is thereby neuroprotective, while preventing this further reduces translation and enhances neurotoxicity. The data support the development of generic proteostatic approaches22,28 to therapy - fine-tuning protein synthesis - in prion, and perhaps other neurodegenerative disorders involving protein misfolding.
All animal work conformed to UK regulations and institutional guidelines, performed under Home Office guidelines. tg3710 and C57/Bl6N mice (Harlan) were inoculated with 1% brain homogenate of Chandler/RML (Rocky Mountain Laboratories) prions aged 3-4 weeks, as described7. Animals were culled when they developed clinical signs of scrapie. Control mice received 1% normal brain homogenate. Hippocampi were processed for protein, RNA or histological analysis7-10. For all analyses n=3 mice unless otherwise stated.
Lentiviral plasmids were generated using the Invitrogen Gateway cloning system29. The neuron-specific promoter CAMKII was used to drive shPrP expression, C-terminal GADD34 expression, or YFP alone (control virus). Viruses were injected stereotaxically into the CA1 region of the hippocampus as described9.
Mice received daily intraperitoneal injections of 1mg/kg of salubrinal (Calbiochem), or vehicle (diluted DMSO in saline (Sigma))25, for 7 days from 8wpi.
Synapse numbers were counted in EM images of the stratum radiatum of the hippocampal CA1 region30. Synaptic marker proteins, UPR pathway proteins and PrP were analysed by immunoblotting of brain homogenates. PrPSc was detected after PK digestion7. Whole-cell recordings were done in acute hippocampal slices to measure synaptic transmission31. Global translation levels were detected using 35S−Methionine incorporation in acute hippocampal slices and translation of specific transcripts in polysomal fractions from hippocampi were analysed by Northern blotting32. Neuronal counts were determined by quantifying NeuN positive pyramidal CA1 neurons9. All analyses were performed using hippocampi from 3 mice in triplicate unless otherwise stated. Burrowing behaviour was performed as described on groups of 10 or more mice8. Statistical analyses were performed using using Prism v5 software, using Student’s t test for data sets with normal distribution and a single intervention. ANOVA testing was performed using one-way analysis with Tukey’s post-hoc test for multiple comparisons.
Lentiviral plasmids were generated by using the Invitrogen Gateway cloning system as described29. att-flanked cassettes were constructed by PCR amplification using att recombination site sequences and 20-25 template specific sequences. The C-terminus GADD34 cassette was amplified from FLAG-tagged C-term GADD34 using attB5 5′-ggggacaactttgtatacaaaagttggcaccatgcgttcaggagaggcgtccga-3′; and attB4 5′-ggggacaactttgtatagaaaagttgggtgttggtctcagccacgcctcccac3′ primers; WPRE and YFP cassettes were amplified from pLL3.7-shPrP plasmid using attB3 5′- ggggacaactttgtataataaagttgtcaacctctggattacaaaatttgt-3′ and attB2 5′- ggggaccactttgtacaagaaagctgggtatgcggggaggcggcccaaagggaga-3′ primers for WPRE and attB4r 5′ accatggtgagcaagggcga-3′ and attB3r 5′ ttacttgtacagctcgtccatgccg-3′ primers for YFP . The CAMKII promoter was amplified from using attB1 5′- ggggacaagtttgtacaaaaaagcaggctacttgtggactaagtttgttcgc-3′ and attB5r primer 5′- ggggacaacttttgtatacaaagttgtctgcccccagaactaggg-3′primers. Cassettes were amplified and recombined into appropriate pDONR entry vectors. Once the entry plasmids were generated they were recombined with the pLenti6/BLOCK-iT/DEST vector (Invitrogen) to construct lentiviral plasmids. We used lentiviral plasmids containing shPrP and empty vector constructs as described9. Lentiviruses were generated using DNA/Ca2+ phosphate transfection of HEK293 cells33. Additional stocks of virus were generated by GenTarget, Inc. (San Diego, CA) and titre determined using FACS (BD FACS Calibur). Viruses were used with a final titre of 0.6-1.5 × 108 TU.
Mice were anesthetized using isofluorane and injected into CA1 region of the hippocampus as described9.
Semi-thin sections for electron microscopy were obtained by terminal perfusion of mice as described30. Ultrathin sections (70 nm) were examined in a JEOL 100-CXII electron microscope (JEOL (UK) Ltd) equipped with a ‘Megaview III’ digital camera (Olympus Soft Imaging Solutions GmbH, Munster, Germany). Synapses were scored using criteria of structures showing a postsynaptic density, containing synaptic vesicles and a synaptic junction. 32 images from two mice were used for scoring.
Whole-cell recordings were made from identified CA1 neurons and recording performed as described30. In brief, neurons were voltage-clamped using a Multiclamp 700B amplifier and pClamp 10.3 software (Molecular Devices) and EPSCs were evoked by stimulation with bipolar platinum electrode at 37°C. Pipettes (2.5-3.5MΩ) were filled with a solution containing (mM): KCl 110, HEPES 40, EGTA 0.2, MgCl2 1, CaCl2 0.1, pH was adjusted to 7.2 with KOH. Neurons were visualized with 60x objectives on a Nikon FS600 microscope fitted with differential interference contrast (DIC) optics. 4-8 cells were measured per mouse in at least 2 animals per experiment.
Protein samples were isolated from hippocampi using protein lysis buffer (50mM Tris, 150mM NaCl, 2mM EDTA, 1mM MgCl2, 100mM NaF, 10% glycerol, 1% Triton X-100, 1% Na deoxycholate, 0.1% SDS and 125mM sucrose) supplemented with Phos-STOP and protease inhibitors (Roche). Synaptic protein levels were determined by resolving 20mg of protein on SDS-PAGE gels, transferred onto nitrocellulose membrane and incubated with primary antibodies, SNAP25, (1:10000; Abcam), VAMP2 (1:5000; Synaptic Systems), NMDA-R1 (1:1000; Sigma) and PSD95 (1:1000; Millipore). Odyssey IRDye800 seconday antibodies (1:5000; LI-COR) were applied, visualized and quantitated using Odyssey infrared imager (LI-COR; software v3.0). Protein for PrP levels and UPR pathway activation were determined using the primary antibodies, 8H4 for total PrP (1:1000; Abcam), ICSM35 for PrPSc (1:10,000; D-GEN), PERK-P, total PERK, P-eIF2a, eIF2a (1:1000; Cell Signaling), CHOP (1:1000; ThermoScientific), Caspase12 (1:1000; Exalpha), BiP/Grp78 (1:1000; Stressgen) and GADD34 (1:1000; ProteinTech). Horseradish peroxidase (HRP) conjugated secondary antibodies (1:5000; DAKO) were applied and protein visualized using enhanced chemiluminescence (GE Healthcare) and quantitated using ImageJ. Antibodies against GAPDH (1:5000; Santa Cruz) or β-tubulin (1:5000; Millipore) were used to determine loading.
Slices were dissected in an oxygenated cold (2–5°C) sucrose artificial cerebrospinal fluid (ACSF) containing (mm): 26mM NaHCO3, 2.5mM KCl, 4 mM MgCl2, 0.1 mM CaCl2, and 250mM sucrose. Hippocampal slices were prepared using a tissue chopper (McIlwain). Slices were allowed to recover in normal ACSF buffer while being oxygenated at 37°C for 1hr, then incubated with [35S]-Methionine label for one hour, then homogenized. Proteins were TCA precipitated and incorporation of radiolabel was measured by scintillation counting (Winspectal, Wallac Inc.).
Sucrose density gradient centrifugation was used to separate hippocampal homogenates into polysomal and subpolysomal fractions. Polysomal fractions were isolated as described32. Briefly, hippocampi were dissected in ice-cold gradient buffer (0.3 M NaCl, 15 mM MgCl2, 15 mM Tris-HCL (pH7.4), 0.1 mg/ml cyclohexamide, and 1 mg/ml heparin). The hippocampal tissue was homogenised in gradient buffer containing RNase inhibitors and 1.2% TritonX-100 added. Samples were centrifuged and the supernatants layered onto 10-60 % sucrose gradients. The gradients were sedimented at 38,000 rpm for 120 minutes at 4°C. 1 ml fractions were collected from the gradients into 3 ml of 7.7 M guanidine-HCL using a Foxy R1 gradient fractionator (Teledyne ISCO; ISCO peak Trak v1.10 software) with continuous measurement of the absorbance at 254 nm. RNA was then isolated and equal volumes of each fraction were analysed by Northern blot analysis32.
Paraffin embedded brains were either stained with NeuN antibody (1:200; Millipore) for neuronal counts. CA1 pyramidal neuron counts were determined using three serial sections from three separate miceAll images were taken on using Axiovision 4.8 software (Zeiss) and counted using volocity imaging system.
Student’s t tests were applied to all data sets with two tails (two samples; unequal variance). ANOVA testing was performed using one-way analysis with Tukey’s post-hoc test for group effects. Statistical tests were performed using Prism v5. All data in bar charts show mean ± s.e.m.
Supplementary information: Supplementary figures 1-10 and legends, Supplementary methods and references.
We thank David Read for imaging analysis, and Jenny Edwards, Tim Smith, Judy McWilliam, Paul Glynn and Colin Molloy for technical assistance; Professor John Collinge (MRC Prion Unit) for the original RML prion inoculum and Professor Ken Liddle for critical reading of the manuscript. This work was funded by the Medical Research Council, UK.
Author contributions: JAM did most of the experimental work and analysis. NV and MGM performed stereotaxic surgery and prion inoculations. HR, DP, MH and JM performed various experiments, DD performed EM analyses, JRS performed electrophysiological analysis, CAO and DAB performed mass spectrometry analysis, PT and AB worked with JAM in Cambridge, AEW and MB contributed expertise and direction on translational control mechanisms, GRM directed and supervised the project. JAM and GRM wrote the paper. All authors contributed to discussion and analysis of data and final draft of paper.
The authors declare no conflict of interest.

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Having a meal at a cosy and most relaxing place can be such a fruitful thing to embark on. Well, I got to admit I got that at The Estate by BIG. Love the setting and backdrop of this eatery located at Intermark. I found it was truly invaded by colonial style yet rusticly in placed.
Before the feast we were served with lovely assorted breads that came with delicious spread of Echire butter. It was really a delicious snack to tease our hunger at that particular moment.
It lmay ooked simple and yet it tasted magnificentlly delicious. Yes I was referring to The Estate’s poarched egg. Having a gentle slit a cross the egg came the running drips of egg yolk. Yes it amazed me right away. My heart was pumping fast. I sensed the present of thinly slice of truffle layered over the hollandaise sauce. I bet you knew I cleaned the plate with the left-over bread till it glowed.
It was light and was pleasant to look at, the Nicoise salad that came to the table. The plate was filled with light refreshing greens topped with amazingly beautiful slices of tataki tuna and hard boiled egg.
What amazed me that day was their Lobster linguine. It had a very strong color and presentation. It was hard not to take notice. I just love the bursting texture of the lobster, it was firm and with delightful biting texture. The linguine was done to my liking, al-dente. Overall it was the wining dish of the day. Yes everyone wanted to own it just for themself. Yes it was an excellent dish.
The Chicken Tikka was very well dressed with great marination. It was succulent in taste and came in pairs. It had a yoghurt dipping, a portion of rice and salad at the side. Great flavour and taste good.
Oh our eyes got freezed for minutes when we were served with their beer roasted spring chicken. It was funny and yet nice that our chicken was served over a can of beer. The spring chicken was well roasted and tasted really good. The roasted spring chicken truly had a distinct beer taste and smell. Very uniquely done, love it. So yummy and a well tentatively roasted chicken in town.
The grilled striplion steak came next. It was grilled perfectly to the request, near done. It was tender and nice. A simple steak that taste good.
The dessert looked rather messy but it was nice to taste. Not overly sweet and came with a macaron too.
The butter and bread was nice to spoon into. A very home comfy dessert.
Jalan Tun Razak,


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- Charles A. Geyer
- Karl Andreas Geyer
- Charles A. Geyer's Botany Journal written on Joseph N. Nicollet's 1838 expedition to survey the Missouri and Mississippi rivers.
- Notes on the vegetation and general character of the Missouri and Oregon territories: made during a botanical journey from the State of Missouri across the south-pass of the Rocky Mountains to the Pacific during the years 1843 and 1844.
- Chronik des Gartenwesens und Feuilleton der Isis: Organ für Gärtner, Gartenbesitzer, Garten- u. Naturfreunde (1851-1853).
- Charles A. Geyer, pioneer botanist of upper Oregon by Thomas R Cox, (Boise, ID : Idaho State Historical Society, 1999)

domain: history


text:
The bottom line: It's a good option for Southwest loyalists who don't care about airline status or side benefits. But it doesn't travel as well as its sibling cards with higher annual fees.
- Earn 40,000 points after you spend $1,000 on purchases in the first 3 months your account is open.
- 3,000 bonus points after your Cardmember anniversary.
- 2 points per $1 spent on Southwest® purchases and Rapid Rewards® hotel and car rental partner purchases.
Pros & Cons
No blackout dates or seat restrictions
Has annual fee
Has foreign transaction fee
Alternate Pick: More flexible rewards
Chase Sapphire Preferred® Card
Elevated earning in popular categories
Earn 2 Chase Ultimate Rewards® points per $1 spent on travel and at restaurants, and 1 point per $1 spent everywhere else. Your points are worth 25% more when you redeem them for travel through the Chase Ultimate Rewards® portal, and you can also transfer points to partner airlines, including Southwest. Annual fee: $95.
Compare to Other Cards
15.99% - 22.99% Variable APR
15.99% - 22.99% Variable APR
Recommended Credit Score
Recommended Credit Score
The Southwest Rapid Rewards® Plus Credit Card isn't the flashiest of the three co-branded Chase cards in the Rapid Rewards family, but that doesn't mean it's the black sheep of the clan either.
After all, the three Southwest cards offer the same APR and ongoing rewards rates, not to mention the same sign-up bonus, which gives you a nice boost toward earning the coveted Southwest Companion Pass. And since the Southwest Rapid Rewards® Plus Credit Card has the lowest annual fee of all the Southwest cards, why wouldn't it win out every time?
Well, for starters, it doesn't travel as well as its two big siblings, nor is it as generous with side benefits. And if you're a loyal Southwest customer seeking extra perks when you travel, it could be that the much pricier Southwest Rapid Rewards® Priority Credit Card will still be a better deal for you thanks to the added value you'll get.
Southwest Rapid Rewards® Plus Credit Card: Basics
Card type: Airline.
Annual fee: $69.
Sign-up bonus: Earn 40,000 points after you spend $1,000 on purchases in the first 3 months your account is open.
2 points per dollar spent on Southwest® purchases and Rapid Rewards® hotel and car rental partner purchases.
1 point per dollar spent on all other purchases
NerdWallet values Southwest points at 1.4 centseach. This is a baseline value, drawn from real-world data on hundreds of economy routes, not a maximized value. In other words, you should aim for award redemptions that offer 1.4 cents or more in value from your Southwest points.
Interest rate: The ongoing APR is 15.99% - 22.99% Variable APR.
Foreign transaction fee: 3%
Anniversary bonus of 3,000 points every new cardmember year
CALCULATE YOUR REWARDS
To see if the rewards you'd earn on this card would make up for the annual fee, try our calculator:
Benefits of the Southwest Rapid Rewards® Plus Credit Card
Low annual fee
The $69 annual fee is relatively low for an airline card with a healthy sign-up bonus and ongoing bonus rewards on airline purchases. For comparison's sake, the Southwest Rapid Rewards® Premier Credit Card charges a $99 annual fee, and the Southwest Rapid Rewards® Priority Credit Card clocks in at $149 per year.
Generous sign-up bonus
Earn 40,000 points after you spend $1,000 on purchases in the first 3 months your account is open. That's a big chunk of points to spend toward free flights, and gets you on your way to the 125,000 points you need to earn the Companion Pass.
Extra anniversary points
For each year you keep your card account open, you'll receive an anniversary bonus of 3,000 points. (You can also earn extra points by booking car rentals and hotels through the Rapid Rewards program, or using the Rapid Rewards Shopping portal.)
Nerd tip: Southwest Airlines credit cards don't offer free checked bags as many airline credit cards do, but your first two checked bags already are free with Southwest. (The checked-bag fee for other major airlines generally is $25 to $30 per bag each way.)
Drawbacks and alternatives
Fewer perks than other Southwest cards
The Southwest Rapid Rewards® Plus Credit Card earns 3,000 anniversary points, half as many as the Southwest Rapid Rewards® Premier Credit Card. Based on point valuation, the difference in the anniversary bonus is more than enough to offset the difference in annual fees between those two cards, making the Southwest Rapid Rewards® Plus Credit Card the worse deal.
And the Southwest Rapid Rewards® Priority Credit Card offers even more benefits to help defray its hefty $149 annual fee. Every year, Priority cardholders get a 7,500-point anniversary bonus, a $75 Southwest travel credit, four upgraded boardings when available (those are worth $30 to $50 per flight), and 20% back on in-flight purchases. Depending on how often you treat yourself to Wi-Fi and a snack, that equals at least $270 in value.
Also, the Southwest Rapid Rewards® Plus Credit Card is the only card of the three that doesn't earn tier qualifying points. Those points count toward elite status, known as "A-List" or "A-List Preferred" in Southwest's programs. Benefits of such status include priority boarding and bonus points for flights you pay for.
Here's a look at how the three Southwest consumer cards compare:
Weak bonus categories
Most purchases will earn you 1 point per dollar, and you'll earn 2 points per dollar on Southwest purchases and Rapid Rewards hotel and car rental partner purchases. But other rewards cards allow you to earn 2 points per dollar on more spending categories without having to shop through a partner program:
The Chase Sapphire Preferred® Card earns 2 points per dollar spent on all travel purchases (you'll earn a total of 5X points on Lyft rides through March 2022) and on dining worldwide, and 1 point per dollar on all other purchases. Its points can transfer directly into the Southwest Rapid Rewards program. It has an annual fee of $95.
With the Capital One® Venture® Rewards Credit Card, you'll earn 2 miles per dollar on all spending, for an annual fee of $95.
Foreign transaction fee
The 3% foreign transaction fee makes the Southwest Rapid Rewards® Plus Credit Card a poor choice to use during an international trip. Neither of the pricier Southwest cards charges a foreign transaction fee.
Is the Southwest Rapid Rewards® Plus Credit Card right for you?
Frequent Southwest flyers will find a lot to love about the Southwest Rapid Rewards® Plus Credit Card because it offers so many of the same benefits as its higher-end siblings.
Just keep in mind that you won't get the side benefits found on the more expensive Southwest co-branded cards. And if you're seeking a card for use overseas, or one that offers more rewards flexibility, consider other options.
on Chase's website
NerdWallet reviews are the result of independent research by our editorial team while cardholder reviews are contributions from independent users not affiliated with NerdWallet. Banks, issuers and credit card companies are not responsible for any content posted on the NerdWallet site, nor do they endorse or guarantee any posted comments or reviews.

domain: finance


text:
Ready to be the next top model? Stella and friends are preparing for a fashion photo shoot and we got to create them the best look. Dress up the models and get ready for the runway show!
If you want to impress everyone with cute and chic hairstyles inspired by your favourite Disney Channel actress and singer - Selena Gomez, then you should hurry up and join us on DressUpWho.com as we are getting ready...
Can you help Kendall Jenner with creating a unique hairstyle for her? http://www.dressup.com
Anna is the daughter of Agdar and Idun, younger sister of Elsa, and princess of Arendelle. She has long strawberry-blonde hair tied into two pigtail braids. Today she wants you to give her a new haircut as she doesn't...
Can you help this cute girl with her hairstyle? http://www.dressup.com
Can you give this lovely greek girl a great hairstyle? http://www.dressup.com
Becky G would love get a new hairstyle. Can you help her? http://www.dressuppink.com
Alice loves to wear colorful clothes and now she would like to have a new My Little Pony themed hairstyle. Could you help her? http://www.girlgames.com/perfect-proposal-ariel.html

domain: entertainment


text:
Ohio State's 2015 recruiting efforts took a hit Sunday afternoon when 4-star tight end Chris Clark committed to North Carolina.
Clark, a 6'6", 247-pound pass-catcher out of Avon, Conn., made the announcement via his Twitter account.
Rated the No. 3 tight end and the No. 126 prospect overall, Clark was one of the most pursued recruits in the country. After hauling in 39 receptions for 417 yards and six touchdowns during his junior season, Clark earned offers from programs such as Alabama, Auburn, Florida State, Georgia, Michigan, Notre Dame and South Carolina.
The Buckeyes, though, were considered the favorite, according to the recruiting experts at 247Sports.
So where does Ohio State go now?
Finding the right player is imperative for Urban Meyer and the Buckeyes. Ohio State didn't sign a tight end in its 2014 class, and with Jeff Heuerman on the brink of his final season, there's a big need for one this year.
The Buckeyes already have offers out to a pair of top 10 tight ends, both of whom reside in the SEC footprint.
The first went out to Garrett Williams last May. The 6'4", 220-pound prospect out of Orlando, Fla., is rated a 4-star recruit, but Meyer and the Buckeyes' coaching staff would need to work some serious magic to sway Williams from Florida State.
Last month, Ohio State sent out an offer to another 4-star prospect in Jackson Harris. The Columbia, Tenn., native has offers from Alabama, Florida State, Georgia, Miami, Oklahoma and Oregon, but Vanderbilt is a strong favorite at the moment.
However, the Buckeyes might not even need to look past their own borders to find their guy.
C.J. Conrad, a 4-star prospect and the No. 8 tight end overall, resides in Lagrange, Ohio, which is about 100 miles north of Columbus.
Meyer has yet to extend an offer to Conrad, but that hasn't stopped a number of recruiting experts from predicting he'll wind up at Ohio State.
Conrad had a fantastic junior season for the Keystone Wildcats, catching 59 passes for 924 yards and 14 touchdowns.
The 6'5", 225-pound standout excels when he's split wide, using his incredible size and speed to present matchup nightmares for the defense. He also isn't afraid to go over the middle and catch the ball in traffic, and his highlight film shows that he can be a capable blocker.
While losing Clark was a big blow for Ohio State, there are still a number of talented tight ends for Meyer to pursue in this year's class.
All recruit rankings, stats and information per 247Sports.
David Regimbal is the Ohio State Football Lead Writer for Bleacher Report.
Follow him on Twitter @davidreg412.


text:
KUALA LUMPUR (Nov 30): After logging 13 consecutive quarters of losses, Mudajaya Group Bhd has returned to the black with a net profit of RM812,000 in its third quarter ended Sept 30, 2019 (3QFY19).
KUALA LUMPUR (Oct 15): Opposition lawmakers today lauded government backbencher Nik Nazmi Nik Ahmad for urging the government to revive the Mass Rapid Transit Line 3 (MRT3).
KUALA LUMPUR (Oct 11): The federal government plans to proceed with the Rapid Transit System (RTS) between Johor Bahru and Singapore to solve the long-standing traffic congestion on the Causeway.
KUALA LUMPUR (Oct 11): Malaysia's real gross domestic product (GDP) is expected to grow by 4.
Construction sector Maintain neutral: We expect the upcoming Budget 2020 announcement on Oct 11 to prioritise public transport projects but limited to those already awarded, revised and approved: Light Rail Transit Line 3 (LRT3), Mass Rapid Transit Line 2 (MRT2) and East Coast Rail Link (ECRL).
KUALA LUMPUR (Oct 4): The East Coast Rail Link (ECRL) — which is anticipated to have a civil works subcontract value of RM9 billion to RM11 billion — is likely to be the only source of immediate new order book for contractors in the upcoming Budget 2020 despite timing risks for new contract awards, says CGS-CIMB Research.
KUALA LUMPUR (Aug 30): Kimlun Corp Bhd's net profit rose 36.


text:
Race against opponents and destroy them with your guns. Tap your finger for the duck to fly up. If you think pharaoh went crazy from all the plagues, just wait until you try smacking all these frogs.
- This app has not relations with "Flappy birds" of ".
What's new in this version:Fix bug for iPhone5/5sImpove performance. Play the Classic Racing game that may only be on old video game tool is hard to find. Its amazing music can be found online in mp3.
and Tweet about it with hashtag #flipabirdWhat's new in this version:Bug fixes Dizzy Ducks is fun and satisfying. Egg Toast========Sometimes an Egg Toast sneaks in.
Play is fun, with us.
You can beat them through the columns, right? Practice up and ask them to download for a fly to fly tapping contest of epic gaming proportions! Fun for all ages of tapping game fans!** Note ** Fantastic Fly is not recommended for iPhone 3GS,iPhone 4, iPad 1 or lesser hardware.
Pick up Dizzy Ducks and play right away. What's new in this version:Added new design, cool new figures and music.Caution : The game is addictive. dear kids, like it Come play with. FEATURES:- 3 different difficulty (easy: 2x3- medium: 3x4- hard: 4x5)- develops recognition, concentration and motor skills of kid- cute sounds for kids- colorful HD graphic designed for toddlers- beautiful images of princess, mermaids, unicorns, pink ponies, .
Corner it, use your own tactics.

domain: game


text:
While stocks got off to a generally upbeat beginning to the week Monday, a few laggards managed to post big losses despite a broader bullish sentiment. The gains were modest; it'd be nice to say that the S&P 500 Index wasn't setting any records, but it actually was: its 3 point gain today, although just a 0.2% uptick, sent the index to 1,695, an all-time closing high.
Yahoo! shares had the most difficulty today, slumping 4.3% as the company lost three members of its board of directors and a high-ranking executive, all in a day's time. No immediate successor is known as media head Mickie Rosen steps down, according to Kara Swisher at AllThingsD. One of the board members, activist investor Daniel Loeb, is also the CEO of the hedge fund Third Point, and his departure comes as Third Point liquidates about $1.2 billion in Yahoo! stock.
Advanced Micro Devices shares continued a precipitous drop Monday that began with Friday's 13.2% slump. Slipping another 3.2%, investors continued a sell-off that began in earnest after the chipmaker reported quarterly earnings that sparked several high-profile analyst downgrades. While today's fall may be to some extent a continuation of Friday's collapse, AMD also saw heightened competition Monday. Intel vowed to start making low-power chips for servers on Monday, as Intel moves more consciously into the server and mobile markets AMD already competes in.
Finally, Sprint , which only recently dropped the "Nextel" part from its trading name, fell 2.5% as it continues a sell-off that began last week. After a 22% rally on the heels of Japan's SoftBank acquisition of the company, shares began to slip last Tuesday, as a slump began that's sheared nearly 12% off Sprint's market cap. Investors will get a better clue about trends at the company when it announced quarterly results next Tuesday, July 30.
It's incredible to think just how much of our digital and technological lives are almost entirely shaped and molded by just a handful of companies. Find out "Who Will Win the War Between the 5 Biggest Tech Stocks" in The Motley Fool's latest free report, which details the knock-down, drag-out battle being waged among the five kings of tech. Click here to keep reading.
The article Today's 3 Worst Stocks originally appeared on Fool.com.
Fool contributor John Divine has no position in any stocks mentioned. The Motley Fool recommends Intel. You can follow him on Twitter, @divinebizkid, and on Motley Fool CAPS, @TMFDivine.The Motley Fool owns shares of Intel. Try any of our Foolish newsletter services free for 30 days. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.
Copyright © 1995 - 2013 The Motley Fool, LLC. All rights reserved. The Motley Fool has a disclosure policy.

domain: economics


Transform security into a seamless experience with our Environment-based Access Control using Digital Tokens – where company protection meets precision, dynamic control and an impenetrable shield against unauthorized intrusions.
By taking into account the dynamic nature of modern work environments and the evolving threat landscape, it provides a robust framework for ensuring that access to resources is secure, controlled, and compliant with organizational policies.
Precision in security unfolds with environment-based access control using digital tokens, where each access is finely tuned to the context, providing a dynamic and granular defense that adapts to the ever-changing digital landscape, ensuring unparalleled protection for your company. It tailors access privileges with surgical precision, ensuring only authorized entities navigate your digital landscape, fortifying defenses against unauthorized intrusion with an impenetrable layer of protection.
Environment-based access control using digital tokens is a sophisticated approach to managing application access rights in computer systems, blending aspects of context-aware security with token-based authentication. This method considers the environmental context or conditions under which access requests are made, using this information along with digital tokens to control access to resources. Environmental factors are contextual elements related to the access request, such as the host location, the time of the access request, or the device being used.


text:
Nail Clipping is important part of the grooming process it aids in keeping your dogs nails to stay short and not overgrown.
All our grooms include complementary nail clipping but we also offer this as a stand alone service.
The Price of this is £5 per dog
We also do small animal nail clipping which includes Rabbits and Guinea pigs for just £5 each
If your wanting to book or have an enquire please send us a message through our contact us page or give us a call to discuss further.

domain: pet


In many households, the modern holiday is a digital experience from start to finish. Recipes and decoration ideas are found online. Emails are sent to confirm who is coming and what they can bring. And help videos are consulted when the bottom of the turkey burns and the inside is still raw.
The digital experience spreads from party prep to the actual celebration. Background music comes from online music services. Absent family members are called via Skype or FaceTime. And sometimes, relatives bring their phones to the table to text or check football scores.
The constant connection is hard for many holiday revelers to handle, and it's one of many worries that surround the holidays. Surprisingly, it's not a modern concern. It turns out, we essentially worry about the same things we did a century ago.
More From Country Living
In looking at vintage magazines, radio scripts, and etiquette books, a shared narrative surfaces about holiday worries and how to address them. In reading these materials, three worries shared among modern families and previous generations emerge.
They also worried about family connection.
Modern parents worried about teens texting at the dinner table can take heart – Americans have long worried we were losing our connection with each other and tried to use Thanksgiving as a bonding day. In 1905, an article in Ladies' Home Journal titled "To Spend an Old-Fashioned Thanksgiving Day" reminisced on how holidays were celebrated in the 1850s and made recommendations as to how Thanksgiving could honor past traditions.
According to the article, guests were supposed to arrive after 10 a.m. to begin prepping the meal. Children were sent into the yard to spend the day playing while the adults cooked and set-up. After the meal was celebrated in the early afternoon, readers were encouraged to play games as a family, sing songs, and dance traditional jigs like the "Virginia Reel."
The article reflected a concern that times were changing, and tried to find solutions as to how the oldest and youngest generations might connect. The author's ideas were to take the games and songs that were familiar to the oldest generation and teach them to the youngest.
Whether the children of 1905 were actually impressed by games and songs from the 1850s is unknown. But the idea had merit—it addressed children's interests and likes, and did so in a way that was comforting and familiar to the oldest generations.
They worried about technology, too.
Many Americans worry we're replacing human interaction with emails, texts, and tweets. The thinking is that people, particularly young adults, will become more dependent on technology and more socially awkward with each other.
This Thanksgiving, many family gatherings will include worry that relatives are on their phones before, during, and after the meal. Are these phone users being rude? Are they addicted? Or just uncomfortable with in-person communication?
Such worry is a long-standing American tradition. An adjustment is needed each time a new technology is introduced. Comic books, for example, were worrisome to many turn of the century parents who thought their boys would develop violent or sinful ideas. When silent movies were first introduced, community leaders and parents worried about the influence. Even the famed social worker, Jane Addams was concerned movies corrupted youth.
The list goes on. When telephones were first introduced, people worried scam artists had easy access to gullible housewives. Fears about television, video games, the Internet, and mobile communication have followed in succession.
People annoyed by texting during Thanksgiving dinner might find some comfort in knowing we're not the first generation to worry about the influence of media on youth. At past Thanksgivings, family members have whispered and frowned over comic books, telephones, Game Boys and more.
They also worried about Christmas creep.
More than a century ago, in 1914, a weekly magazine out of Minneapolis called "The Bellman" complained the holiday season was becoming too long. The stretching of the season, the author vexed, meant greater preparations and stress. It was a disturbing trend that drained people's nerves and their pocketbooks.
The same concern continues today. Christmas decorations have been popping up in retail spaces since before Halloween. And some stores are open on Thanksgiving Day to give Black Friday shoppers an early start.
Twenty-four hour shopping might be a modern phenomenon, but the concerns about holiday excess have troubled Americans for more than a century. The "Bellman" author worried the economy was already dependent on holiday gift giving.
However, the writer had helpful solutions for navigating an extended holiday season: Simplify spending; and give yourself full freedom to enjoy any sincere expression of friendship, joy, or the spirit of the season.


At Gamescom 2021, Deadmau5 made a surprise appearance to announce his new virtual fan hub and concert space, 0B3HASL1. The creative space will run via the game Core, which is game and platform combined into one. In it, you can create, play, and share your own games for the world to enjoy. With it being featured on a game-creation platform, downloading and playing OB3HASL1 will be easy!
Unfortunately, there is no official link to download the game. However, that doesn't make playing the game any more complicated. When OB3RHASL1 is released in October 2021, players can partake in the experience via the Core platform, which is currently available for free on the Epic Games Store. This means that you can prep for OB3HASL1's release by downloading the game on the Epic Games Store or Launcher, then simply wait for its release to download the virtual hub experience through the game.
While you wait, you can also enjoy a myriad of games that are currently available via the Core platform, including some of the games feature in the OB3HASL1 announcement trailer shown below.
Want to see the opening trailer featured Deadmau5 revealed at Gamescom 2021? Check out the video below!


Posted by Jerry Hildenbrand on 10 Apr 2012 12:40 am
One of the things folks really (really) like about Android 4.0 is the way you can disable system applications from the settings menu. It doesn't delete them, but it does keep them quiet and out of the way while perusing the app drawer. Anything that gives more control to the user is a good thing, and we're just as glad to see it as you guys are. Adios, City ID!
But for some apps, it makes very...
Posted by Jerry Hildenbrand on 20 Mar 2012 5:40 pm
HTC and Sprint are getting together a few weeks from now in New York to show us something. We'll be there -- anytime there's a chance at seeing Android phones, an open bar, or catered hor d'oeuvres we're gonna show up. The real question, the one we all want to know, is what exactly will they be showing us?
The last time Sprint held a big shin-dig they showed us the Kyocera Echo. Everyone...
When the first leaks of HTC's new crop of devices started trickling out, a funny thing happened -- folks started to fall in love with HTC Sense all over again. Only this time, it was for what Sense wasn't doing. The on-screen widgets appeared to have been toned down. Gone was the large and inflexible series of buttons at the bottom of the home screens, apparentl replaced by a more traditional-...
Portions of this page are modifications based on work created and shared by the Android Open Source Project
and used according to terms described in the Creative Commons 2.5 Attribution License. AndroidCentral is an independent site
that is not affiliated with or endorsed by Google.