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Announcing a new article publication for Zoonoses journal. Escherichia coli (E. coli) is one of the most common pathogens causing clinical mastitis in cattle, but no vaccine is available to prevent this disease in China. Therefore, development of an E. coli vaccine against bovine clinical mastitis is urgently needed. In this research, the candidate vaccine (Ch-O111-1) and challenge (LZ06) strains were screened from milk samples of cows with clinical mastitis. To extend the cross-protection of the Ch-O111-1 strain, the galE gene fragment of the Ch-O111-1 strain was deleted through homologous recombination between the Ch-O111-1 strain and pCVD442/ΔgalE plasmid, which was identified through conventional methods, including PCR, SDS-PAGE and sequencing. The Ch-O111-1/ΔgalE (Z9) strain was characterized by extensive cross-reactivity and attenuated virulence. Inactivated Z9 vaccines with different adjuvants were prepared. The results demonstrated immunization of inactivated Z9 antigen induced adjuvant-, dosage- and inoculation time-dependent antibody titers in cows and mice. Furthermore, immunization with SP01-adjuvanted inactivated Z9 vaccine protected cows against severe clinical mastitis caused by LZ06 and protected mice against death due to LZ06. An SP01-adjuvanted inactivated Z9 vaccine was successfully developed and found to protect cows against severe mastitis caused by Escherichia coli.
Keywords: mastitis, Escherichia coli, cow
Zoonoses is fully open access journal for research scientists, physicians, veterinarians, and public health professionals working on diverse disciplinaries of zoonotic diseases.
Zoonoses is now open for submissions; articles can be submitted online at https://mc04.manuscriptcentral.com/zoonoses
Please visit https://zoonoses-journal.org/ to learn more about the journal.
Editorial Board: https://zoonoses-journal.org/index.php/editorial-board/
Zoonoses is available on ScienceOpen (https://www.scienceopen.com/search#collection/839df240-327f-47dd-b636-9b728dff9700).
There are no author submission or article processing fees.
Follow Zoonoses on Twitter @ZoonosesJ; Facebook (https://www.facebook.com/Zoonoses-Journal-100462755574114 ) and LinkedIn (https://www.linkedin.com/company/zoonoses/)
Article reference: Xinyu Li, Chongyu Tian and Hui Han et al. Development and Efficacy Evaluation of an SP01-adjuvanted Inactivated Escherichia Coli Mutant Vaccine Against Bovine Coliform Mastitis. Zoonoses. Vol. 2(1). DOI: 10.15212/ZOONOSES-2022-0039


text: I’ve listened to Kendrick Lamar once and off that one time I judged him and said ehhh not for me. Well after getting 48 seconds into this video I have decided to go out and get his album off of the deepest depths of the free internet music space. Don’t tell no body. Anyways I’m wasting my download time to get to listen to this album, Section 80. So I’m done with this watch the video and put someone on.

domain: artistic


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domain: design


Health IT Cluster
The New Zealand Health IT Cluster is a vibrant alliance of organisations interested in health IT. It is comprised of software and solution developers, consultants, health policy makers, health funders, infrastructure companies, healthcare providers, and academic institutions - who have agreed to work collaboratively.
The Health IT Cluster and the National Health IT Board are looking to form a new type of engagement between health information and communication technologies (ICT) decision-makers and the health ICT industry. Our joint approach is based on similar exercises undertaken by Canada Health InfoWay, NeHTA in Australia and MedCom in Denmark - all of which have impressive and valued engagement exercises in their respective jurisdictions.
Partnership meetings will be held on a six-monthly basis to build relationships and reset the model of engagement between the sector and vendors.


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The Ed Show
America's clean bill of health
In Trenders, Ed Schultz and Dr. Corey Hebert discuss the quick and efficient treatment of Ebola in the U.S.
Greta: A Debt of Gratitude to Ebola Responders01:43
'Ebola nurse' Kaci Hickox suing Chris Christie04:38
Liberian president talks Ebola victory04:55
Bob Geldof talks 'Band Aid' Ebola campaign01:03
Ebola czar: 'Today is a milestone'07:00
NYC Ebola survivor: ‘Today, I am healthy’03:53

domain: medical


Gloria Borger speaks to Senator Lindsey Graham about the latest report from the House Intelligence Committee on Benghazi.
CNN's Gloria Borger's exclusive interview with Vice President Joe Biden.
CNN's Gloria Borger sits down with Vice President Joe Biden and discussed the mid-term election and America's future.
Gloria Borger reports on the Louisiana Senate race that includes alligators and a possible December run-off.
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Enjoy the most bohemian Buenos Aires, in the heart of San Telmo, steps from Plaza Dorrego,
Pirámide de Mayo and also the Obelisco, through narrow cobblestone streets
illuminated by lanterns to the rhythm of tango.
With refurbished facilities and a cobbled courtyard, there is no lack of details to transport them to the
personal universe of San Telmo.

domain: geography


text:
DR. ERIC CHAPMAN
783 EAST 12300 SOUTH
DRAPER UT 84020
Mon. - Thur.: 8 am - 6 pm
Select Saturdays: 9 am - 2 pm
Emergency situations with your pet can be filled with anxiety and fear. Dr. Eric Chapman and the Draper Animal Hospital staff are trained to help eliminate your fears by providing knowledgeable and timely treatment for your pet's needs. We are fully equipped to handle daytime emergencies. We first assess the situation, when you call our clinic, and recommend either immediate attention or schedule a convenient appointment time. Once at the hospital, our trained team provides you and your pet the attention and care necessary to deal with the situation.
Draper Animal Hospital business hours:
Monday - Thursday, 8:00 a.m. - 6:00 p.m.
Friday, 9:00 a.m. - 2:00 p.m.
Every Other Saturday, 9:00 a.m. - 2:00 p.m.
For after-hours emergency care for your family friend, please contact:
Advanced Veterinary Care
1021 E 3300 S
Salt Lake City, UT 84106
Contact Draper Animal Hospital today to discuss your pet's needs,


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Our Practice AGA is a well-established architectural firm that provides expert design consultation in support of our mission to create a more enriched environment. Our project portfolio reflects the depth of our dedication and exemplifies our ambitions for a modern architectural firm.
Our home-grown architectural practice, Atelier Group Architects, was founded in 1979 and has gathered works of all sizes and purposes.
We’ve worked hard over the years to establish an architectural practice that delivers modern and adaptable solutions to meet current needs. Today, as we grow beyond our humble beginnings, we stay encouraged to do good deeds and work hard to attain our goals.
Our firm was formed as AGA Architects Private Limited on August 8, 2008, in order to chart new horizons and diversify our business. We will continue to retain our dedication to create exceptional works, both locally and internationally, from our headquarters in Singapore.
Each design starts with a thorough grasp of the program and the environment.
We take pleasure in working together with our customers and consultants to develop suitable techniques to meet the program’s needs.
The affinity of our architecture to the area and the context that characterizes the place inspires our ideas. We aim to promote an understanding of the contextual aspects by working at different sizes. We were enthralled by the quest of clues that led to design solutions with intrinsic contextual sensitivity.
The concepts of our designs are informed by the discipline of contemporary architecture, which emphasizes the importance of inquiry and exploration in the design process. We aim for innovation and originality in every development. The space, light, and structural order of our architecture help us achieve both excitement and peace.
Various degrees of knowledge and execution of concepts that arise from the design process are at the heart of our work.
Individuals who like exploring, analyzing, and adapting to new circumstances are eligible for internships. All levels of interns are encouraged to apply.
You will be exposed to a variety of initiatives throughout your time at AGA. Real-world exposure to varied architectural activities, from concept design to managing actual building on site, is what you will benefit the most from our internship programs.
SUTD Scholarship – AGA
The AGA – SUTD Scholarship was founded to give chances to excellent students studying Architecture and Sustainable Design (ASD) at SUTD.
The fellowship is offered to full-time students from all nationalities who want to pursue or are already enrolled in the Architecture and Sustainable Design pillar of study at SUTD.
Our AGA is built on the concepts of interaction and exchange.
Each member of AGA brings a unique set of skills, disciplines, and experiences to the table. Individual encounters, we feel, contribute to stimulate creativity and, as a result, deepen the dynamics of our profession.
We understand that design must be influenced by ongoing exchanges of ideas, expertise, and experiences. Our work culture’s comprehensive approach is reflected in the practice of continuous discussions. The intellectual variety of our open studio is the backbone of our practice.
You may also like
Red Bean Architects
Red Bean Architects is a creative studio of architects and designers led by 2 partners, Teo Yee Chin and Zeeson Teoh based in Singapore and was founded in 2009.
AR43 Architects is an architectural firm based in Singapore founded in 2006 and is known for landed housing, institutional, and community building designs.
SCDA Architects Pte Ltd
SCDA is a design studio led by Principal Soo K. in 1995 that focuses on creating holistic spatial experiences.


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Many Catholics back birth control decision
The Archdiocese of San Antonio recently asked for your prayers.
The archbishop and auxiliary bishop are hoping these entreaties move President Barack Obama to reverse a mandate that even health care plans in Catholic-affiliated institutions fund birth control as preventive care. Ultimately, Catholic institutions will be using less subtle pressure.
But I have a different prayer. That the president not make second-class citizens of folks working for Catholic-affiliated institutions, Catholics and non-Catholics both.
Respectfully, let me suggest that this is a difficult conclusion to reach. The people who people these institutions are doing precisely what the institutions would prohibit. That would be partaking of birth control — the reason that all those married couples attending Mass don't have 10 to 12 kids in the pews with them every Sunday. Those non-Catholics working for these institutions don't have as many either, by and large.
In fact, that person in the pew hearing of this letter is thinking, “Um. Wait a sec; I use or have used birth control.”
Most people, including Catholics, want birth control to be affordable and accessible. Which makes the administration's second-guessing of itself here puzzling. A spokesman said Tuesday that the president might be open to compromise. He shouldn't be.
Conscience is a big deal in the church. But the phrase means nothing if it is imposed, as in “your conscience is what I say it is.”
García-Siller and Cantu do draw a distinction in one part of the letter about which Catholics they are talking about.
“As a result, unless the rule is overturned, we Catholics will be compelled either to violate our consciences or to drop health coverage for our employees (and suffer the penalties for doing so),” they wrote.
The “we” there is obviously referring to health care providers. The problem is that what these honchos view as a violation of conscience, the honchees pretty much view as a matter of health necessity and personal choice — babies on their terms, not the church's.
Churches are already exempted, by the way. They are, by design, about the propagation of faith and are properly given leeway. But Catholic-affiliated institutions aren't just about spreading faith, though they may, admirably, be about living it.
They teach — and not just religion and not just to Catholics. They treat, cure and employ people, but not just Catholics. They follow the laws governing these services in the process.
Funny, in any case, how there are no pangs of conscience about imposing Catholic beliefs on non-Catholics.
It's instructive that at least six states have firmly worded clauses that allow a pharmacist to refuse to sell contraceptives to customers as a matter of conscience. Texas is not among them. The state's Pharmacy Board nonetheless tells pharmacists to do two things in such cases (generally when the so-called morning-after pill is involved): Follow your conscience but take steps to make sure access isn't denied.
When it comes to health care providers, there can be no difference between that drugstore and the Catholic-affiliated institutions. A church's immunity from laws governing the rest of us is not absolute, particularly if what it seeks is to deny a right accorded all others.

domain: politics


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Nashville Music Producer Receives Praise For Work On Indie Country AlbumPosted: May 16, 2017 Filed under: Testimonials Leave a comment
High praise from The Swanson’s, a band from the Los Angeles area Nashville Trax producer, Bill Watson, is producing a country album for, Regarding the first song’s final for-radio mix of their project.
“Getting Ready sounds great, Bill! I don’t know what else to say other than praise God!!! Extraordinary!!”- Joe Finley


2.5W Capsule LED G9 Cap 240volt Warm White
£ 2.82Product number: ATL/LC/G9LED252700CRItem out of stockOpal finish 2.5w G9 LED is a direct replacement for the traditional 18w halogen capsules, commonly used in desk lamps, pendants, cabinets and accent lighting. Perfect for domestic and commercial use. With a colour temperature of 2700k and a 210 lumen output this non dimmable bulb will give that warm glow we all associate with old fashioned halogen whilst considerably reducing your energy consumption.
£ 2.35 Excl.Tax


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Housing Benefit appeals
Dealing with your appeal
When we receive your letter of appeal we'll look at the decision again to make sure it is correct.
If we think the decision is wrong we'll send you a new decision letter explaining what we've changed and how this has affected your appeal.
If we think the decision is correct we'll send your appeal and an explanation of the law and facts used to make our decision to the Tribunal Service. We'll also include any other relevant papers. This is called the response. A copy of the response will also be sent to you and to your representative, if you have one.
The Tribunal Service will then send you a form that must be completed and returned to them within 14 days. You can use this form to provide further evidence about any special needs you may have, to request an oral or paper hearing or withdraw your appeal.
Please note: if you do not return the form on time, your appeal will end.
Once your completed form is received by the Tribunal Service they'll arrange an oral or paper hearing. They'll send you a letter telling you about this.

domain: law


text:
75 Crown Street, Woolloomooloo, NSW, 2011
(02) 9001 2000
East Sydney Private Hospital is fully equipped for the following range of surgical services for both adults and children.
East Sydney Private Hospital. has received both its State and Federal Hospital Licenses and is ready to undertake surgery and procedures.
Our commitment is to provide patients with the highest standards of health care. Our staff will ensure that throughout your stay you will be as comfortable as possible.
We only employee top level staff that will ensure that throughout your stay you will be as comfortable as possible.
First class facilities, top rated doctors and surgeons, amazing staff and a wide range of services.
East Sydney Private Hospital works with top rated doctors and surgeons across NSW and Australia.
Click Here For Google Map >
Click here to find our services, book online or contact us.
Click here to find information about visiting patients.


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The Nike M2K Tekno are currently part of the most popular Chunky Sneakers. Real soon-to-be-classic, it’s hard to be indifferent to these Sneakers !
But where to buy the “Atmosphere Grey” colorway ?
Mounted on a chunky White sole which seems to be made of a multitude of layers, the Nike M2K Tekno Atmosphere Grey has a well made colorway.
Easily dressed in Grey, the upper is made of a plurality of leather, mesh and synthetic inserts, assembled in a silhouette which reminds us the design of 90s Sneakers worn by family men : the Dad Shoes.
These androgynous Chunky Sneakers are enhanced by some bright Orange hits : on the inserts which links the heel and the sole, and on the embroidered mini-swoosh of the Nike M2K Tekno.
Where to buy the Nike M2K Tekno Atmosphere Grey ?
These Nike M2K Tekno Sneakers are available on Nike website, and at select retailers as Caliroots, Sneakersnstuff or Asphaltgold. They are priced at 100€.
In other news, discover the New Balance 608, Chunky Sneakers available at 85€ !
Photos : Asphaltgold


Privacy Norms in AI-based Systems
Natalia Criado, José Such, Stefan Sarkadi – King’s College London
The aim of this project is to create the building blocks for AI-based systems to be able to learn and reason about the privacy norms users would like AI-based systems to follow. This is crucial to increase users’ trust in such systems. The main outcomes will be novel hybrid AI models to represent, learn and reason about privacy norms.


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- Arrowood Farm Brewery in Accord
While the term "farm brewery" conjures bucolic images of picnic tables amidst chicken yards, hop yards, and barns, with a backdrop of rolling hills, the actual New York State term denotes a license type that requires brewers to use a certain percentage of New York State-grown ingredients. But back to that pastoral vision, we've rounded up seven farm breweries in the Hudson Valley that are located on working farms, and use produce grown onsite, from hot peppers to plums to rye, in their beers.
Arrowood Farm Brewery236 Lower Whitfield Road, Accord
Located on 48 pastoral acres in Accord, Arrowood collaborates with neighboring farms to source fruit, grain, and botanicals from within 100 miles. At the farm, laze in a hammock while you sip a beer or play a round of cornhole. If you're lucky you'll catch a glimpse of the sheep wandering through the hopyard.
Gardiner Brewing Company699 NY-208, Gardiner
Located on Wright's Family Farm, Gardiner Brewing Company opened its doors in fall 2018. Set on 453 acres, the fifth-generation family farm produces apples, stone fruit, and berries, many of which make their way into the brewery's seasonal beers. Sit on the flagstone patio and take in the sunset over the Shawangunk Ridge, and stay late for live music.
West Kill Brewing2173 Spruceton Road, West Kill
Located on a historic dairy farm in the Catskills, West Kill Brewing uses hyper-locally grown and foraged ingredients and crystal-clear mountain spring water to make beers that capture the terroir. Sit outside by the fire pit and enjoy views of the Catskills with your beer before you head to the nearby Spruceton Road trailhead for a hike.
From the Ground Brewery245 Guski Road, Red Hook
Two-year-old From the Ground Brewery, on Migliorelli Farm outside the Village of Red Hook, grows much of the barley for its beer onsite and sources all its hops from New York State. Stroll the scenic property with its pond and rolling hills, before buying a selection of their three year-round beers or limited-edition bottles with their pastoral watercolor logos.
Obercreek Brewing Company59 Marlorville Road, Wappingers Falls
With 14 acres, you'll have plenty of space to spread out at this organic-certified produce and herb farm. Three-year-old Obercreek Brewing uses ingredients from its own farm and other New York State producers to create a wide range of IPAs, farmhouse ales, and other styles. They currently have four beers on tap.
Plan Bee Farm Brewery115 Underhill Road, Poughkeepsie
This bucolic brewery, sited on a 25-acre working farm outside Poughkeepsie, specializes in barrel-aged and wild-fermented brews made with yeast cultivated from the beehives. The seasonal selections at Plan Bee feature farm-fresh ingredients like the Nasturtium, a zingy ale with the distinctive peppery flavor of the namesake flower petals. Wander the property, order from the rotating food trucks, and spread out a blanket on the lawn.
Old Klaverack Brewery
150 Thielman Road, Hudson
Leave the beaten path and head to Old Klaverack in Hudson, which features a quarter-acre hop yard of climbing green, corn hole, live music, and picnic tables. This two-barrel nano brewery produces a range of small-batch beers, including a cream ale, a stout, IPAs, seasonal specialties, and limited releases.

domain: food


Your Weekly Dose of News in Pharma, Biotech and Health
The UK's 'Golden Triangle' is set to expand with new lab and manufacturing facilities as a new £1 billion life science campus gains approval for construction. Former biotech leader Vivek Ramaswamy's emergence in U.S. presidential polls raises questions about his impact on the life sciences sector. Meanwhile, YouTube takes steps to combat misinformation about cancer treatment, while radiation therapy, a traditional cornerstone of cancer treatment, sees a decline in usage. Deep-seated issues in the U.S. healthcare system, from drug shortages to high prices, come to the fore. Biopharma companies report optimistic earnings amidst a growth surge. The industry takes a comprehensive approach by conducting a 360° survey to listen to the voices of sites and patients. In the marketing domain, the evolving commercial model witnesses the rise of a new pharma marketer, and Bristol Myers releases a corporate brand 'anthem' film celebrating its scientific endeavors. Pharma companies also seek collaboration with medical social influencers in novel agency partnerships.
More lab and manufacturing space coming to the UK's 'Golden Triangle'
As former biotech leader Vivek Ramaswamy jumps in the presidential polls, what does he say for the life sciences brand?
YouTube cracks down on misinformation on cancer treatment
Radiation, a mainstay of cancer treatment, begins a fade-out
From drug shortages to high prices, U.S. system’s shortcomings have deep roots
Biopharma half-time report: Riding growth wave with upbeat earnings
Listening to Site and Patient Voices – 360° Industry Survey
The rise of the new pharma marketer in an evolving commercial model
Bristol Myers debuts corporate brand ‘anthem’ film on digital and social channels, celebrating its science and people
Pharma companies look to tap medical social influencers in new agency partnership
For an overview of previous Weekly Notables, visit our Archive


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The incidence rate of MPN-BP is lowest in ET, ranging from ~1% to 4%; it is around 4–8.7% in PV and ~15–22% (up to ~30% in some studies) for primary myelofibrosis.5,6 The time to onset of MPN-BP varies but is long, measured in many years to decades.
Several studies examined risk factors to predict time to onset of MPN-BP based on clinical and chromosomal information. The individual studies assessed different metrics over time and used different scoring systems, hence there are some variations in the clinical parameters used to predict a higher risk of progression into MPN-BP. Commonly associated prognostic factors for an increased rate of transformation include leukocytosis (>30 × 109/L or >25 × 199/L in the Dynamic International Prognostic Scoring System-Plus (DIPSS-Plus)), thrombocytopenia (<100–150 × 109/L), and anemia (<10 g/L) (with respect to time to onset of anemia),7 as well as unfavorable karyotype (either defined within prognostic risk scores such as the Lille Score or the newer DIPPS or DIPSS-Plus for individual chromosomal aberrations) or defined as complex karyotype with >3 aberrations, similar to AML.2,4,6,8,9 In most studies, leukocytosis, increased blood blasts (>1–3%), progressive anemia, and thrombocytopenia, as well as monosomal or complex karyotype, seem to play particularly important roles.2,4,6,8,9 Finding a monosomal/complex karyotype or other unfavorable cytogentic chromosome aberrations that were not present previously indicates clonal progression. Practically, if we see patients whose leukocytosis and/or peripheral blood blasts steadily rise (i.e., from 2% to 6% and 10% over a 6–12-month period), with progressive cytopenias, this may necessitate a marrow biopsy and closer observation and initiate the process of possibly proceeding to an allo-SCT. Comparable to myelodysplastic syndrome (refractory anemia with excess blasts, RAEB-2) the higher the percentage of blasts (i.e., >10% in marrow in some studies), the higher the risk of progression. There is a higher frequency of a FAB morphological M6 and M7 subtype in MPN-BP leukemias compared to de novo AML.4
Hydroxyurea, if given alone or if not used concurrently or sequentially with cytoreductive therapy (mainly alkylators or radioactive phosphorus, 32P) does not appear to increase the risk of LT. However, 32P and alkylator treatment during the disease course were associated with 4.6- and 3.9-fold increased risk of LT.10 Thus, in younger patients one needs to be careful of the sequence and the agents used during the entire treatment time.
There are attempts to characterize which patients may be at higher risk for LT if hydroxyurea or other cytoreductive drugs are used. For example, in a recent study of four genes involved in pathways repairing DNA damage and providing protection against genotoxic DNA damage (in this study, nucleotide excision repair and base excision repair pathways), a specific Gln/Gln genotype in the XPD (ERCC2) gene at codon 751 showed the strongest association with LT (odds ratio, 4.9; 95% confidence interval, 2.0–12) but was also associated with development of non-myeloid malignancies.11 Data such as these provide evidence about the contribution of inherited genetic variations to the pathogenesis and clinical/treatment course of MPNs and other malignancies, with the hope one day of testing for specific higher-risk genetic predisposition in patients who are at risk. As of today, prudent use of sequential or concurrent alkylators with hydroxyurea should be exercised.
Recognizing disease acceleration of myelofibrosis heading towards LT is important, as the median survival of patients with MPN-BP is only approximately 3–6 months4,5 in earlier studies. It may be slightly higher in recent papers (Table 21.1), possibly due to an effect of aggressive management and close observation of patients at risk, and proceeding quickly to allo-SCT.12 Thus, early recognition of disease acceleration and initiating allo-SCT evaluation are crucial as allo-SCT is the best (and currently only) chance for a potential cure. Ideally allo-SCT should be performed prior to the onset of LT in the accelerated phase of myelofibrosis (see below).
|Therapy||Composition||Median survival in months|
|Allogeneic stem cell transplantation||3.9–10.5|
The exact etiology and molecular processes leading to LT are unknown. However, several of the commonly found mutations in myeloid malignancies (MPNs, AML, myelodysplastic syndrome) seem to occur at higher frequency in MPN-BP vs. the chronic state of the respective MPN, indicating a possible contribution to LT. This chapter cannot adequately reflect on the complex molecular aspects of MPN-BP and we refer the reader to other sources.
Does JAK2 play a role?
JAK2 mutations are the most common mutations. Some papers report an increase in the JAK2 allele burden from heterozygous to homozygous upon progression within the myelofibrosis stage. However, JAK2 is not necessarily involved in transformation and there seem to be alternate JAK2-independent routes to LT, which may even be more common.13 In another study, all JAK2 V617F patients remained JAK2-positive and all JAK2 V617F-negative cases remained negative at LT, reinforcing the notion that other molecular event(s) may play a role in the clonal heterogeneity of MPNs. Thus, in addition to the well-described clonal evolution at the cytogenetic level, additional genetic and molecular changes apart from JAK2 mutation and signaling promote LT. A detailed description of the molecular and genetic events or genes involved is beyond the scope of this chapter, especially as there is still controversy about the contribution of each of these events in the pathogenesis of LT. Below we will highlight frequencies and occurrences of mutations and their differences between the chronic state of MPNs and MPN-BP.
Other mutations in MPN-BP
Mutations that have been found at a higher freqeuncy in MPN-BP versus the initial MPN (PV, ET, and primary myelofibrosis) are 21% vs. 1–4% for IDH1 and IDH2 mutations; DNMT3A, 14% vs. 3–7%; LNK mutations are around 10% in MPN-BP vs. rare occurrences in PV/ET/primary myelofibrosis; ASXL1 18% vs. 3–13%, and SRSF2 has been reported at 18.9% in MPN-BP. TET2 mutations appear to be equally common in MPN-BP (~17%), PV (16%), and primary myelofibrosis (17%).14 It should be emphasized that different studies conducted in different patient populations from different groups have slightly varying frequencies of mutations; for example, in a recent study of 54 MPN-BP patients, TET2 mutation frequency was 28.3% and that for DNMT3A only ~2%.15
On LT, there is an increase in complex karyotype, indicating the acquisition of additional genetic damage and lesions. For example, in our observation a complex karyotype with three or more abnormalities was found in around 18.7% and baseline and 53.6% at leukemic transformation,4 confirmed by other studies to be in a similar range.16 Acquisition of deletion/monosomy of chromosome 5, 7, and trisomy 8 were common. This is similar to other acute leukemias, where a more complex karyotype indicates a worse disease biology. In addition to cytogenetic abnormalities, an increasing number of mutations have been identified that have a role in the initial formation of MPN/myelofibrosis,14 as well as, later on, transformation into acute leukemia. Several specific cytogenetic alterations have been observed at loci that harbor genes known to be involved in leukemogenesis; for example, deletion in 7p corresponding to the transcription factor IKZF.17 Mutations/loss of the tumor suppressor gene p53 are higher as well.
Treatment of MPN-BP is challenging and there is no standard of care. Many of the treatment concepts are derived from AML. Several groups, including our group, have reported on the outcome of myelofibrosis at LT.4,12,18,19 Patients eligible for induction therapy should undergo chemotherapy. However, achieving complete remission in MPN-BP has not, or only modestly, improved overall survival, although a complete response is still a prerequisite to proceed to allo-SCT. Therefore, we generally treat patients with induction chemotherapy if there is a plan to proceed to allo-SCT. Since there is usually a time interval at the stage of myelofibrosis, donor and transplant issues can be planned and available donor determined.
The choice of induction chemotherapy varies and the same regimens as in AML are used. The CR and CR with incomplete count recovery (CRi) rates are comparable to poor-risk de novo or secondary AML and are broadly in the range of 40–50% for the general MPN-BP population,4,12,18,19 although some studies show up to 71% CR/CRi with standard AraC plus anthracycline.18 The response kinetics and time-to-count recovery are also delayed given the significant bone marrow fibrosis in these patients. Overall survival ranged from 2.7 to 6.6 months for the general population. Overall survival in patients receiving chemotherapy and a CR was in the range of 3.9–9.4 months, again showing a broad range, but with only minimal improvement of survival after chemotherapy alone.4,12,18,19 Long-term survival is possible in selected patients, with some patients being alive at follow-up of up to 47 months posttransplant (Table 21.1). A few studies analyzed the outcome after combined induction chemotherapy followed by hematopoietic allo-SCT for eligible patients, showing median survival rates in the order of 10.5 with a range of up to to 47 months, clearly better than with chemotherapy or lower-intensity treatments alone, but still rather poor overall. In our recent series of MPN-BP patients, approximately 40–50% achieved 20 months or longer survival rates, and an important factor for long-term survival is achievement of a CR,19 if followed by allo-SCT.
A large recent retrospective study confirmed the validity of a systematic “aggressive” treatment approach consisting of close momitoring of patients during their myelofibrosis stage and induction chemotherapy followed by allo-SCT for eligible patients.12 Of 75 MPN-BP patients, 38 were eligible to receive induction chemotherapy; 18 achieved a CR/CRi and 11 a second chronic phase of MPN; 17 of the 38 chemotherapy patients proceeded to allo-SCT. Patients treated with this curative-intent approach (e.g., chemotherapy and/or planned to be followed by allo-SCT) (similar to an intention-to-treat analysis) had a median survival of 9.4 months and a 2-year overall survival of 26%, much better than the 2.3 months and 3% 2-year overall survival in the group that received non-curative lower-intensity or supportive-care approaches. Outcome was even better for the patients who completed allo-SCT, with a 2-year overall survival of 47% (median overall survival of 47 months) vs. 17% (median overall survival of 9.4 months) for those who achieved CR/CRi in the second chronic phase of MPN after induction chemotherapy, but who did not go on to allo-SCT. Importantly, patients undergoing induction chemotherapy but not proceeding to allo-SCT had a similar median overall survival compared to the low-intensity treatment group (9.4 vs. 6.6 months, respectively). Similar results were found by us and other groups.
In conclusion, MPN-BP should be treated with induction chemotherapy followed by allo-SCT for eligible patients. Which induction regimen achieves the highest CR/CRi rates is unknown, but this is important, as CR is a prerequisite for allo-SCT. We use standard 7 + 3 or often try to incorporate cladribine, such as in the CLAG-M regimen (R. Tibes, personal communication). Of course, a clinical trial should be considered if patients qualify. Achievement of a CR/CRi or possible second chronic phase in conjunction with allo-SCT is essential for long-term survival, and the potential for cure with allo-SCT.
Hypomethylating agents have shown some activity in MPN-BP patients who are not induction- and/or transplant-eligible. The largest study from the French group has reported on 54 patients with either LT after primary myelofibrosis or post-ET/PV myelofibrosis (26 of the 54 patients) or development of a myelodysplastic syndrome/MPN clinical picture (28 of the 54 patients). All patients were treated with azacitidine. At a median follow-up of 20 months, the overall response rate (CR + CRi + partial response) for MPN-BP patients was 38% (10/26 patients), with only 2 CRs; the median overall survival was 8 months for the MPN-BP patient group treated with azacitidine.20 Other smaller case series have shown the activity of decitabine in MPN-BP, with a median survival of greater than 9 months from time of LT, as well as symptomatic improvements and spleen size reduction.21 However, it should be noted that this latter is a case series which included only 6 patients. Thus, while hypomethylating agents have activity, their overall experience and overall benefit in MPN-BP are still limited. Nevertheless, for MPN-BP patients who are ineligible for induction chemotherapy and/or allo-SCT, a default lower-intensity treatment option can be hypomethylating agents alone or preferred combination on a clinical trial.


Ben Folds Five
About Ben Folds Five
Ben Folds Five is a trio formed in Chapel Hill, North Carolina, United States in 1994, who until their breakup in 2000 were a mainstay of piano rock. Much of their work was influenced by jazz, evident in frequent improv-styled passages through bridge and/or ending. The members of the band are Ben Folds, the lead singer and pianist, who also wrote most of the songs; Robert Sledge on bass; and Darren Jessee on drums. The group enjoyed the success of the single Brick in 1997, a ballad written by Folds (with a chorus by Jessee) about his high school girlfriend getting an abortion. Read more about Ben Folds Five on Last.fm.


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In the following example, a gyil sounds the three-against-two cross-rhythm hemiola. The choir sing a melody in triple time, while the bass instruments in the orchestra play a 4-beat ostinato against this.
Obviously practicing correctly at home will dramatically increase your results, but as an instructor the only time I can control is class time. Conveniently located on RT9, Clifton Park. I got lucky and found some amazing players,not all of them guitarists, who taught me more in the first hour of knowing them than "lessons" ever did.
Bach C minor Passacaglia Variation 2 Bach C minor Passacaglia Variation 2 In common with other Passacaglias of the era, the ostinato is not simply confined to the bass, but rises to the uppermost part later in the piece: We have not had a price beat on a new gear purchase yet!
Obviously practicing correctly at home will dramatically increase your results, but as an instructor the only time I can control is class time.
I am open to the idea that someone could possibly develop a breakthrough system for group classes, but in general they are of value only to intermediate or advanced students.
If you are ready to learn to play with confidence and style, drop me an Email at rockguitarlessons gmail. Literally the best decision I've ever made for my soul.
In the first of his Three Pieces for String QuartetStravinsky sets up three repeated patterns, which overlap one another and never coincide. Monteverdi Laetatus sum Ground bass Later in the same century, Henry Purcell became famous for his skilful deployment of ground bass patterns.
Obviously practicing correctly at home will dramatically increase your results, but as an instructor the only time I can control is class time. Its your money and your life which you have to prioritize.
However, the foreign influences are interpreted through a distinctly African ostinato sensibility. We continually monitor the phones and email to ensure that we are able to assist you when you call or email us! Purcell Fantasia in 3 parts to a ground The intervals in the above pattern are found in many works of the Baroque Period.
They were my teachers although they weren't employed as instructors. Purcell Fantasia in 3 parts to a ground The intervals in the above pattern are found in many works of the Baroque Period. Online lessons require no special hardware outside of a webcam. No bad habits at all.
I brought my guitar everywhere and tried to make friends with anyone who knew anything at all. Professional Recording Studio in our school Modern Day Studios is a full blown professional Pro Tools HDX recording facility with high end outboard gear, microphones and acoustically treated rooms.
Not one of them could ever give me any answer except "practice. Purcell, Dido's Lament ground bass Purcell, Dido's Lament ground bass While the use of a descending chromatic scale to express pathos was fairly common at the end of the seventeenth century, Richard Taruskin points out that Purcell shows a fresh approach to this musical trope: Online lessons require no special hardware outside of a webcam.
A famous type of ostinato, called the Rossini crescendo, owes its name to a crescendo that underlies a persistent musical pattern, which usually culminates in a solo vocal cadenza.
These are usually only offered by corporate chain stores and corporate referral services.
Ostinato figures are also played on string instruments such as the koragankoqui bell ensembles, and pitched drums ensembles. If you've never taken lessons or played guitar before know this: The results are just as effective as in person lessons!
But let me qualify this: I have helped many others in the same scenario become really impressive guitarists. But the technology has been there for years now and my online students make the same rapid progress my in-person students do.
If you want me to get on your ass about practicing, I am happy to, but you must specifically request it. Mozart uses an ostinato phrase throughout the big scene that ends Music 101 guitar 2 of the Marriage of Figaroto convey a sense of suspense as the jealous Count Almaviva tries in vain to incriminate the Countess, his wife, and Figaro, his butler, for plotting behind his back.Recently I had a client bring in his guitar with a common complaint: The back of its neck felt sticky against his fretting handwhen he was rocking out onstage.
I hear this a lot, especially from players who have guitars with the type of high-gloss finish shown in Photo 1. The truth is, any neck.
Other Music-related Sites; The Violin Site: Very useful violin resources for students, teachers and performers, such as: midi files to improve practicing time, violin teacher directory, violin pedagogy resources, free violin sheet music, violin making and much more.
An American Treasure, a four-CD box set of unreleased music from the Tom Petty vaults, is coming September 28th. The song, career-spanning collection will feature dozens of previously unissued recordings — alternate versions of classic songs, rarities, live performances and deep tracks.
The following classical guitar files are available for download via BitTorrent. Since some of these files are not in the public domain, you may only download these.
Classical music. Ostinati are used in 20th-century music to stabilize groups of pitches, as in Stravinsky's The Rite of Spring Introduction and Augurs of Spring. A famous type of ostinato, called the Rossini crescendo, owes its name to a crescendo that underlies a persistent musical pattern, which usually culminates in a solo vocal cadenza.
This style was emulated by other bel canto composers.
Save money on Used Amplifiers at Guitar Center. All pre-owned items are rated and scored. Buy online or at your local store today!Download


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Lauren Moye, FISM News
FBI Director Christopher Wray discussed an increase in ambush and murders of police officers on Sunday’s episode of 60 Minutes.
“Violence against law enforcement in this country is one of the biggest phenomena that I think doesn’t get enough attention,” the FBI Director began. He then pointed out that almost one officer was killed “every five days” in 2021.
According to CBS News, there was a 59% increase in murders of police officers, making for a total of 73 officers killed in the line of duty in 2021.
While explaining why the numbers were up, Wray stated, “Some of it is tied to the violent crime problem as a whole. But one of the phenomena that we saw in the last year is that an alarming percentage of the 73 law enforcement officers killed in the line of duty last year were killed through things like being ambushed or shot while out on patrol.”
He states that officers’ deaths were up because their badge made them a personal target of criminals.
This is something that Wray’s law enforcement division has experienced personally, with the deaths of FBI Agents Laura Schwartzenberger and Daniel Alfin, both shot through a door before they could execute a search warrant for child pornography.
Wray’s statement is consistent with other groups that have recorded an increase in officer ambushes. The National Fraternal Order of Police (FOP) found a 91% increase in ambushes during the first half of the year, a number which had jumped to 139% by the preliminary report issued at the end of the year. FOP reported 86 different ambush-style attacks that resulted in 26 officer deaths.
Although the FBI Director discussed an increase in ambushes, both host Scott Pelley and Wray did not discuss why this number has surged. FOP President Patrick Yoes did not hesitate to make his thoughts known in a November statement: “Due to lingering animosity toward law enforcement officers, overheated political rhetoric, and a decline in respect for law and order – we are seeing an increase in violence that specifically targets officers.”
The demonization of police was an unfortunate byproduct of calls for justice after several high-profile police brutality cases, such as George Floyd’s murder by white police officers, that contributed to the racial unease of 2020. The resulting calls for “Defund the Police” were noted at the time for their impact on officer morale, as well as the concern it would negatively impact law enforcement safety while they served their local communities. These concerns, it appears, have been justified by statistics.
Not only have officer ambushes risen, but the communities themselves have been made more unsafe through this rhetoric. FISM recently reported, “Data has shown that such extreme cries for defunding of the police actually brought a massive uptick in murder and black Americans were just proportionately affected.”
Several of the pioneer “Defund the Police” law enforcement reform cities have since backtracked on their movements, under pressure from surging violent crimes. President Biden and others in the Democratic party have also begun to try to distance themselves from the narrative, though several in the progressive caucus, particularly Cori Bush, have now doubled down on the faulty narrative.

domain: news


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I had the honor of attending and performing at the Thanks Jimi Festival in historic Wroclaw, Poland. The festival—which celebrated its 10th Anniversary this year—takes place every May 1st in the beautiful Old Town Market Square. It was founded by Leszek Cichoński both to honor Jimi Hendrix, and to break the Guinness World Record for Largest Guitar Orchestra, which it has done several times over. This year, the festival topped its own previously set record when more than 7, 300 guitarists played "Hey Joe" with ecstatic abandon. It is impossible to convey the feeling of looking out over thousands of mostly young guitarists playing Hendrix classics such as "Little Wing" and "Red House," and participating in the eruption of cheers when the official count was announced. Congratulations to all!
Leszek Cichoński surrounded by great guitarists from Poland and beyond. Performing at various points were Bernie Marsden, Gwyn Ashton, Stan Skibby, Michał Urbaniak, Zdenek Bina, Artur Lesicki, and bassmeister Marcus Miller, who wowed the crowd with a raucous version of the Beatles' "Come Together."
I played a live-looping rendition of "Third Stone From the Sun" using a very cool guitar loaned to me by fine folks at Fibenare Guitars in Budapest, Hungary. Here, I'm using an iPhone to play the sound of Jimi's voice through the pickup. "And you'll never hear surf music again."
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1. I feel a sudden urge to sing the kind of ditty that invokes the spring — and worry not, folks, we’re in the home stretch. This Valentine’s Day weekend, on Friday night in Bangor check out Stripped Acoustic Night at Nocturnem Drafthaus, featuring songwriters Danny Herasymchuck and Jim Sobanik and indie rock project Greasy Grass, while over at Tantrum there’s the Trendy Robots, there’s rockabilly band the Crown Vics are at Paddy Murphy’s, Everett Dumas is at the Big Easy, rockers Sudden Karma are at the Downunder Club, while up in Orono, Eric Green plays dirty solo blues at Black Bear Microbrew, and the Great North Collective plays at Woodman’s. On Saturday — Valentine’s Day! — there’s an array of fun events, including Sam Chase and friends at Paddy’s, folk trio the Otter Folk at the Big Easy, the ribald and wildly entertaining Bangtown Swingers at Nocturnem, an encore dance performance of the Haus of Paradigm’s enchanting bellydance spectacular “MIO” (pictured above) at Tantrum at 8 p.m. At the Next Generation Theatre in Brewer, bluegrass ensemble Nevah performs at 7:30 p.m., and up in Old Town, rock machine the Blast Addicts are set for the Boomhouse. On Sunday, comedian Jim Jeffries is set for 7:30 p.m. at the Collins Center for the Arts.
2. On Friday in Portland it’s the perfect night to go out for those single folks who don’t want to be harassed by happy couples. Check out one of these fine events, including Young the Giant and Wildling at the State Theatre, 80s cover band The Awesome at Port City Music Hall, there’s epic local rock with Covered in Bees, El Malo and Monsters at Empire, there’s songwriter James Montgomery at One Longfellow Square, the Raging Brass reggae horns are at Bayside Bowl, at Flask, it’s Foundation Friday featuring deep house and techno DJs Ian Hammond, A Dude Named Ray and Mr. Dereloid, and at the Space Gallery, garage punk band Great Western Plain kicks off its East Coast tour with guests Endless Jags, Video Nasties and SS Cretins. On actual V-Day, there’s some great stuff going on including Stripwrecked Burlesque’s Valentine’s Day show at Geno’s Rock Club, the Dapper Gents with dance troupe Collective Motion at One Longfellow, comedian Jim Jeffries at the State Theatre, funk band Model Airplane at Port City, at Andy’s Old Port Pub, there’s the Breakwater Blues Band and at Brian Boru there’s Gorilla Finger Dub Band.
3. Just an FYI, folks: Friday night is supposed to be truly brutally cold. Like so brutal it’s metal. Be careful out there! If you are brave, on the Midcoast on Friday there’s some fun stuff including Grateful Dead tribute band Shy Green at the Speakeasy in Rockland, there’s By The Bay Jazz Trio at Rock City Coffee, and at the Strand Theatre in Rockland, you can heat up with the Cajun sounds of Beausoleil and Michael Doucet (pictured above). On Saturday, take your sweetie out for V-Day and enjoy either Velocipede at Rock City, a dance with Two Dollar Pistol at Trackside Station in Rockland, bluesman Blind Albert at the Speakeasy and there’s rocker Cranston Dean at Myrtle Street Tavern, also in Rockland.
4. Let’s catch up with some great local theater happenings, shall we? At the Grand Theatre in Ellsworth playwright Brent Hutchins presents his new play, “Closer to Home,” a series of vignettes about Maine life, with performances set for 7:30 p.m. Thursday, Friday and Saturday and a 2 p.m. matinee Friday. Meanwhile, in Belfast the Midcoast Actor’s Studio presents the eastern Maine premiere of the contemporary play “Venus in Fur,” (pictured above) a two person tour de force about the 19th century book of the same name, which partially inspired the term masochism — like “50 Shades of Grey,” except better and more real and not exploitative. But I digress. Performances are set for 8 p.m. Fridays and Saturdays and 5 p.m. Sundays at the Playhouse on Church Street in Belfast. Finally, Ziggurat Theatre Ensemble, based out of Bowdoinham, perform an all-new play entitled “The Puzzle Box,” an experimental work, with performances set for 7 p.m. Friday and Saturday at Mayo Street Arts.
5. Finally, this weekend is the winter edition of Great Maine Outdoor Weekend, with tons of events — over one hundred in total — all over the state for your outdoors enjoyment. From cross country skiing to snowshoeing to nature walks to skating to hiking, there’s something for anyone willing to bundle up and head outside. There are too many specific events to list here, but a full list of all the fun stuff set for Friday, Saturday and Sunday can found online at greatmaineoutdoorweekend.org. Have fun!


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In addition to Southern comfort favorites like the original recipe fried chicken and mashed potatoes, the staff at this KFC will show you plenty of Southern hospitality, gladly answering questions and making recommendations. The restaurant prides itself on its excellent customer service, aiming for 100% customer satisfaction in the dining room and the drive-through. This KFC boasts extra crispy chicken, something not offered at many other locations.
- Hours: Dine-in hours: Daily, 10:30am - 10pm. Drive-through hours: Sun - Thu, 10:30am - 10pm; Fri, Sat, 10:30am - 11pm.
- Handicap Accessible: No
- Payments accepted: American Express, Cash, Debit Card, Discover, MasterCard, Visa
- Products: Fried chicken, soft drinks, mashed potatoes, baked beans, biscuits
- General services: Eat-in, Phone orders, Take-out
- Menu link: www.kfc.com/menu
- Specialties: Extra crispy chicken.
- ATM: No
- Parking: Free lot
- Private events: Yes
- What makes this community special?: The close-knit network of customers and their pleasantness.
- Cuisine: American, Fast Food, Southern
- Signature dishes: Original recipe fried chicken, grilled chicken
- Price level: $
- Number of tables: 15
- Features: Catering, Dinner, Kids' Menu, Lunch
- Atmosphere: Fun
- Dress code: Casual


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What is the best way to decrease cholesterol with diet?
- Choose fats that are better for you. Both total fat and saturated fat should be kept to a minimum. Limit your intake of cholesterol-containing foods. Consume a sufficient amount of soluble fiber. Consume a large amount of fruits and vegetables. Omega-3 fatty acid-rich seafood should be included in your diet. Limit your intake of salt and alcohol.
What reduces cholesterol quickly?
How to Lower Cholesterol in a Short Amount of Time
- Fruits, vegetables, whole grains, and legumes should be prioritized. Take care to limit your fat consumption. Increase your intake of plant-based protein sources. Reduce your intake of refined grains, such as white flour. It’s time to get moving.
What reduces cholesterol quickly naturally?
Salmon, mackerel, herring, walnuts, and flaxseeds are some of the foods that contain omega-3 fatty acids. Increase the amount of soluble fiber in your diet. Soluble fiber can help to lower the amount of cholesterol that is absorbed into your system. Soluble fiber may be found in a variety of foods, including oats, kidney beans, Brussels sprouts, apples, and pears, among others.
How quickly can cholesterol be lowered through diet?
Nieca Goldberg, MD, medical director of the Joan H. Tisch Center for Women’s Health at New York University Langone Medical Center, says it can take between three and six months to see a reduction in LDL cholesterol levels through diet and exercise alone, and that it takes longer for women to see changes than it does for men.
What foods should you avoid if you have high cholesterol?
Foods to avoid if you have high cholesterol
- Dairy products with added fat. All forms of whole milk, butter and full-fat yogurt and cheese include a lot of saturated fat. Meat that is red in color. Beef cuts such as steak, ribs, pork chops, and ground beef tend to have significant levels of saturated fat and cholesterol. Fried foods. Baked products and desserts. Shellfish. Processed meat.
Does drinking more water lower cholesterol?
dairy products in their natural fat form Saturated fats are abundant in whole milk, butter, full-fat yogurt, and cheese.; The consumption of red meat is encouraged. Beef cuts such as steak, ribs, pork chops, and ground beef are known for having high saturated fat and cholesterol levels. Fried foods. Baked goods and desserts. Eggs. Shellfish. Lean meats.
What are the warning signs of high cholesterol?
In what ways may high cholesterol be recognized as a problem?
- Nausea, numbness, slurred speech, extreme exhaustion, chest discomfort or angina, shortness of breath, numbness or coldness in the extremities, high blood pressure, and other symptoms
Are bananas good for cholesterol?
Fruits such as avocados and apples, as well as citrus fruits such as oranges and bananas, can aid to decrease cholesterol levels in the body. Cholesterol may also be derived from the meals we eat, making it critical to nourish your heart with the correct nutrients in order to minimize harmful cholesterol levels. It is possible to lower LDL cholesterol levels by consuming healthy fats and soluble fiber.
How can I lower my cholesterol in 30 days?
In 30 days, you may lower your cholesterol by following these 5 simple steps.
- Reduce cholesterol in 30 days with these 5 simple steps.
What can cause a sudden increase in cholesterol?
The following medical disorders have been linked to elevated cholesterol levels:
- Insulin deficiency (insufficient synthesis of the hormone insulin)
- Kidney disease
- Cushing syndrome (excess hormone production)
- Hypothyroidism (underactive thyroid)
- Liver illnesses such as cirrhosis and nonalcoholic steatohepatitis
- Liver transplantation
Can you reverse high cholesterol?
If your cholesterol levels are out of whack, lifestyle changes should be your first line of defense against it. Unsaturated fats, soluble fiber, and plant sterols and stanols can all help to raise good HDL cholesterol while lowering harmful LDL cholesterol. Exercising and losing weight can also be beneficial. Trans fats and smoking are both dangerous and should be avoided at all costs.
How quickly does oatmeal lower cholesterol?
Dietary changes and exercise are the first line of defense if your cholesterol levels are out of equilibrium. Increasing good HDL cholesterol and decreasing bad LDL cholesterol can be accomplished by the consumption of unsaturated fats, soluble fiber, and plant sterols and stanols.. Additionally, exercise and weight loss may be beneficial. The consumption of trans fats and the use of tobacco are both dangerous and should be avoided.
Can you be healthy with high cholesterol?
High cholesterol can be passed down via families, but it is more typically the result of poor lifestyle choices, making it both avoidable and curable. A good diet, frequent exercise, and, in some cases, medication can all aid in the reduction of elevated cholesterol levels.
Is canned tuna good for lowering cholesterol?
Replacement of high-saturated-fat meats with healthier alternatives, such as fish, is an effective strategy for lowering cholesterol levels. Certain species of fish also include omega-3 fatty acids, which are beneficial to the heart. Salmon, albacore tuna (both fresh and tinned), sardines, lake trout, and mackerel are all excellent alternatives for seafood.
How can I lower my cholesterol without medication?
Here are nine methods for lowering your cholesterol levels without resorting to medicine.
- Consume less harmful fats and more omega-3 fatty acids. Consume more fiber and less added sugar. Limit alcohol use and quit smoking. Exercise on the majority of days. Establishing appropriate sleeping patterns is important.
Can you eat eggs if you have high cholesterol?
Consume less harmful fats and more omega-3 fatty acids. Consume more fiber and less added sugar. Limit alcohol consumption and stop smoking. Most days, you should engage in some form of exercise. Educate yourself about good sleep hygiene.


Games Reviews: Resident Evil Archives: Zero
Friday 22 January 2010
Eek! Here’s a Resident Evil title that’s seriously scary, but for all the wrong reasons. Capcom has dragged this GameCube title out from the crypt and tried to breathe new life into it by releasing it on the Wii. But this early-Noughties numberis neither a retro classic nor something worth revisiting, not least because zero effort has been put into updating it.
Life & Style blogs
Well, it seemed like a good idea at the time: 10 worst gadgets of recent times
Crystal meth addict 'gouged out his eyes and ate them' while high on drug, Australian MP claims
The secret to a great sex life revealed: Two cups of coffee a day
What do the emoji on Snapchat mean?
Teenager tries to buy elderly homeless man breakfast at McDonald's but is told homeless people cannot be served under 'new policy'
As a white man, I'm surprised more women aren't tweeting the hashtag #KillAllWhiteMen
Scotland may have to leave the EU even if it votes to stay in, David Cameron confirms
Report finds that Britain's wages are the most unequal in Europe
The day that Britain resigned as a global power
Almost a third of school pupils believe 'Muslims are taking over our country', study claims
Gay marriage 'Bert and Ernie' cake bakery found guilty of discrimination in Northern Ireland
- 1 Toddler throws a tantrum at the White House – in front of Barack Obama
- 2 Irish people are travelling home from all over the world so they can vote to legalise gay marriage
- 3 Picture of couple posing with beached dolphin 'that later died' causes outrage
- 4 16-year-old girl beaten and burned alive by lynch mob in Rio Bravo, Guatemala
- 5 Witch doctor arrested after forcing newborn baby to walk in Indian village
iJobs Gadgets & Tech
£40-50K: Guru Careers: We are seeking an experienced Software / C# Developer w...
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Little arose to disrupt the holiday lull yesterday and prices were narrowly mixed and the new issue market was dormant
Dealers made some markets among themselves, but the post-Christmas, pre-new Year holiday week left municipals with few buy-side players in attendance. Treasury traders reported and equally dull day.
After a lackluster session, tax-exempt prices were quoted narrowly mixed by session's end.
In secondary dollar bond trading, Los Angeles MTA AMBAC 5 1/4s of 2023 were quoted at 5.38 % bid, 5.35 % offered; New York City Water 5 1/2S of 2019 were at 5.56% bid, 5.54% offered; add Dade County, Fla., 5s of 2013 were 5.25% bid, 5.23% offered.
In other action, Florida MPA 5.10s of 2025 were quoted at 5.35% bid, 5.33% offered; Orange and Orlando FGIC 5 1/8s of 2020 were 5.35% bid, 5.30% offered; and Florida Board of Education 5.20s of 2023 were quoted at 97 3/8-3/4 to yield 5.37%. New York UDC 5 3/8s of 2023 were quoted at 7.72% bid, 5.70% offered.
In light follow-through business, J.P. Morgan Securities freed from syndicate restrictions $128 million Valdez, Alaska, Marine Terminal revenue refunding bonds for the BP Pipelines Inc. project.
In late secondary trading, the 5 3/8s of 2023, the only maturity in the deal, was quoted at 100 1/8 bid, 100 1/4 offered to yield about 5.374%. The bonds were originally priced at par.
In debt futures, traders were disappointed by the Treasury market's performance and sold tax-exempt contracts in sympathy. The March December contract settled down 7/32 at 103.30.
In the short-term note market, yields were unchanged to five basis points higher on the day. In late action, California Rang were quoted at 2.08% bid, 2.00% offered; New Jersey Trans were quoted 2.10% bid, 2.00% offered; New York City Tans were 2.12% bid, 2.05% offered; and Texas Rans were 2.08% bid, 2.00% offered.
Recent demand for California paper has been particularly strong because $2 billion of the state's revenue anticipation warrants matured on Dec. 23. The consequent squeeze in the California sector depressed interest rates by more than the modest declines seen in the broader market.
The remainder of the week is likely to offer little price movement, players said. They said that the market tone remained firm, mainly from a dealer bid for bonds. The Street is anticipating low January issuance arid slightly stronger demand from bond funds, which have some cash available from Jan. I redemptions and various other payments. Reflecting that situation, The Blue List of dealer inventory fell $54.3 million yesterday, to $1.81 billion.
The Bond Buyer calculated 30-day visible supply yesterday at a paltry $2.92 billion. Visible supply has totaled less than $5 billion for seven straight business days.


text:
Chickenpox: what's wrong with catching it naturally?
WHAT ARE THE DANGERS?
It is important that children do not pick at the spots to avoid scarring. But as Dr Terry John, from Walthamstow, says: 'We can never predict who will end up with scarring. In some cases children are scarred without picking at the spots.'
The spots can be infected with bacteria, in which case antibiotics will be prescribed. In adults, the illness can be far more serious, can lead to pneumonia and can even be fatal. In very rare cases, adults may suffer brain inflammation.
Professor Finn says: 'No one understands why. It just seems that the infection is more aggressive.'
Infected children must stay away from pregnant women who have not had chickenpox, especially during the first 20 weeks of pregnancy or the last days before the birth.
In rare cases, the babies of women who get chickenpox in pregnancy may suffer low birth weight, eye problems or developmental difficulties.
A pregnant woman who has been exposed to chickenpox should see a doctor immediately for an injection of varicella zoster immune globulin (VZIG) - antibodies to fight the illness.
WHAT IS SHINGLES?
This is an excruciatingly painful skin eruption in people who have had chickenpox, often years before. It gets its name from the Latin word cingulum, meaning girdle or belt, because of the way it spreads around the trunk of the body. Shingles is also known as herpes zoster.
The chickenpox beds down in the nerve endings, then lies dormant. When it is reactivated, the patient will feel unwell with pains for a few days. There may be fever and nausea. It seems to be associated with lowered immunity.
Shingles spots are small fluidfilled blisters which form a band along the length of a root nerve and turn yellow. It is more common in the over 50s.
'It's probably because your immune system gradually gets tired and debilitated as you get older,' says Prof Finn. Complications can include paralysis of the face, loss of hearing and vertigo and damage to the eye.
HOW IS SHINGLES TREATED?
The antiviral drug Acyclovir should be given within 48 hours of the onset of the attack, usually heralded by a tingling sensation in the affected part. This can cut short an attack dramatically.
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text:
03 November 2021
I first trained as a ‘Myers Briggs Type Indicator’ (MBTI) practitioner over 20 years ago. Over that time I’ve used the personality type tool to inform my work coaching individuals and developing leadership teams. Recently, I undertook the training for MBTI Step 2. It’s refreshed my thinking and given me a deeper understanding of the DNA of an individual’s personality. The more in-depth reporting allows me to provide a highly personalised profile and a development plan which can be used for individuals and teams.
Updating my skills has taught me a valuable lesson. During the pandemic I’ve had to flex and adapt to the changing world, adapting my offer to fit changing client needs. The key skills and tools I use each day needed to be sharped and refreshed to ensure they are fit for the new purpose. Whilst it’s great to have decades of practical experience, it’s also invaluable to refresh the theoretical knowledge that underpins the experience.
I think it is critical for leaders and leadership teams take the time to reassess their mindset, leadership style and skills. As we move forward and plan for 2022 and beyond, I think you need to make sure you are honest and open about your own mindset, skills and preferred styles of working. Take the time to make sure you’ve got the most up to date resources possible, and you’re not relying on old information and learning. As I found, a short training course or reassessment of skills can refresh and inform your thinking.
To find out more about MBTI Step 2, or if you would like to have a full MBTI Step 2 profile completed, please get in touch. If you’d like to have a chat about how you might want to evaluate your leadership team and plan for the future, that’s great too. Just give me a call and we can have a coffee whilst discussing next steps.

domain: psychology


text:
Aware of the ongoing offshore green transition Stena Drilling has taken a preemptive step, signing a strategic framework agreement for decarbonisation exploration with UK-based dCarbonX to support the development of offshore geoenergy resources.
Both parties are interested in so called offshore decarbonisation exploration.
The companies said yesterday they will work together to engineer solutions to discover and develop subsurface assets for combinations of geothermal energy, molecular energy storage, and carbon sequestration.
When we cannot change the direction of the wind, we must adjust our sails
Erik Ronsberg, CEO of Stena Drilling said: “We’re pleased to sign an agreement with dCarbonX to advance our journey in the energy transition. This innovative partnership dovetails well with the work Stena is doing in sustainability, research into cleaner fuels and emissions reduction. By employing the skills that our company has built up over the years and utilising our drilling units to explore for geothermal energy, CO2 and other gas storage locations which dCarbonX have identified, we will be able to play a positive part as the first decarbonisation exploration driller working towards a low carbon future.”
Tony O’Reilly, CEO of dCarbonX said: “Stena Drilling is the obvious strategic partner for our future offshore decarbonisation exploration activities given its world class fleet of modern drillships and semi-submersible offshore drilling units.”
Stena Drilling owns four ultra-deep water drillships and two semi-submersible midwater drilling rigs.
Stena Drilling is moving fast to eye up new business areas as its old staple, oil and gas, becomes less attractive. Splash reported earlier this week that for the first time, capex committed in offshore renewables overtook offshore oil and gas last year – $51bn versus $41bn.
Similarly, last week, Keppel, one of the best known rig builders in the world, announced plans to exit rig building to focus on renewables.
“When we cannot change the direction of the wind, we must adjust our sails,” commented offshore veteran Venkatraman Sheshashayee on the Keppel decision last week.


text:
There’s no doubt choosing a vacation destination isn’t easy. For those planning to travel with kids, you can turn the page now. For those looking for a relaxing beachside vacation with amazing food and drinks, modern amenities and sunsets our East Coast just can’t compete with, look no further than The W Punta de Mita.
Centrally located on Mexico’s Pacific Coast, the W Punta de Mita provides the quintessential escape from North Jersey. Following a nonstop flight no longer than that to California, you arrive in Puerto Vallarta. A quick drive later and you’re in the lush hills of Punta de Mita, and your getaway begins.
Once you’ve arrived at the W’s entry gate you hop on a golf cart that takes you along a winding road surrounded by tall walls which are further dwarfed by the dense trees lining the pathway to the hotel’s lobby. It’s simple to see why celebrities covet this property – the privacy is second to none.
Built into a beachside hill, the W Punta de Mita’s expansive property, along with its clever design, seamlessly blends the entire property into the surrounding nature. With only 119 guest rooms, including villas and suites, you’ll often feel like the property is your own private oasis, complete with a beautiful pool, incredible restaurants and a 700,000-plus tile mosaic walkway hundreds of feet long leading you out to views of the Pacific’s blue waters and wild sunsets.
Like most W properties, W Punta de Mita’s contemporary design gives it a youthful vibe while also celebrating the area’s cultural roots – whether it be the surfboard bed-headboards paying homage to this surfer’s haven or the abundance of luchador wrestling masks and candy skulls found throughout the property. In many ways, the property is a contemporary American hotel with open room concepts and modern amenities, but with fun reminders that you’re actually in a Mexican paradise.
The W has found the perfect formula mixing both fun and relaxation. While there’s no shortage of hidden spots to tuck yourself away and quietly read a book, there are also great spots to socialize with other guests.
Whether you start your day at the W’s state of the art fitness facility, get a massage at AWAY Spa or enjoy a surf lesson, the spot you’ll find the most guests at once is the incredible pool. Overlooking the beach and central to the property, the large pool, dotted with cabanas and an abundance of lounges, is an Instagrammer’s dream. On certain days the pool transforms into a day club, complete with a DJ and endlessly flowing bottles of champagne. Even on quiet days though, the pool is always buzzing. It doesn’t hurt that there’s always an attentive attendant waiting to deliver you a drink without ever having to leave the pool.
If that Tequila Sunrise cocktail has your stomach growling though, just hop out of the pool and head over to Chevycheria, a 1950’s 3800 Chevy truck converted into a beachside ceviche bar. If you prefer some fresh guacamole poolside, the Wet Deck (and their “adult ice cream”) is a must. Laying in the pool and watching the sun disappear behind the western horizon, what could be better?
If just lounging poolside isn’t your thing, than the W Punta de Mita still has plenty to offer. Besides those surf lessons, you can also rent stand up paddle boards, surfboards or boogie boards, and the hotel has partners that will help you plan activities and excursions, such as sunset sails, dolphin or whale watching expeditions, scuba and hookah diving, snorkeling tours and luxury yacht charters. If you’re looking to keep it on land though, a short drive to the neighboring city of Sayulita is perfect for a day of shopping or a night out to experience authentic local culture.
After a quick taxi ride you’ll be fully immersed in a buzzing beachside town. They beach is a bit swarmed, but watching hundreds of locals surfing at the same time is a unique sight. Local artisanal boutiques specializing in clothing and local art line the streets, and delicious tacos costing less than a U.S. dollar are everywhere. At night, the streets come alive with nightclubs and corner bars. If that’s your cup of cerveza (beer), it is quite a scene.
Back at the W though there’s still plenty of relaxation and eating to be had. First, the AWAY spa, another of the hotel’s gems seemingly built into the hillside, offers up plenty of services that allow you to detox before you retox. Whether you indulge in one of AWAY’s signature pampering treatments utilizing local ingredients such as cactus and agave, take in an after-sun body wrap or just simply want to channel your zen in the resort’s “Meditation Labyrinth,” you’ll be well suited for the day’s retox, and by that I mean a Mezcal tasting curated by the property’s knowledgeable mixologists.
Between the sun and the surfing, you’ll find yourself undoubtedly hungry. If you’re feeling some casual Mexican cuisine, Venazu is where you’ll head for a bountiful breakfast buffet with local staples such as mini quesadillas or chilaquiles (essentially breakfast nachos). Open for lunch and dinner as well, Venazu’s more casual and local fare utilizes many local fresh ingredients.
For another option, head just across from Venazu to Spice Market. Inspired by the street markets and food stalls famed chef Jean-Georges Vongerichten came across while traveling in Southeast Asia, Spice Market’s family style cuisine and relaxed and sexy atmosphere will definitely hit the spot.
Looking to have the only table at the restaurant? Mesa1 is an individual table on its own private island with sweeping oceanfront views offering just one daily seating for an ultra-intimate chef’s dinner.
As the temperatures of northern New Jersey continue to sink lower and lower, now’s the perfect time to plan an escape. Nestled in the hills of Mexico’s west coast, the W Punta de Mita is the hidden gem offering everything you could need.
By Brandon Goldstein


text:
In which the interview with Al Ewing — begun last week — is concluded.
COLIN SMITH: To what degree does the writer of fantastical fiction have a political responsibility, and who’s that responsibility to? To put it another way, to what degree is a comics writer responsible for not being political in their work, however that’s supposed to work, as a great many folks evidently believe?
AL EWING: It’s impossible for a writer not to be political in their work. The decision to avoid being “political” is itself a political decision – by avoiding the questions, you’re giving an answer to them. If you exist in the world, your view of the world is going to filter into your work one way or the other – that’s your politics shaping the story. Even if you try to avoid it, everything in the story is going to be informed by your societal views, even if it’s in very tiny, subconscious ways. So given that you’re going to be political whatever you do, you might as well shrug your shoulders and face that head on. That way you can look where you’re going.
On the question of responsibility – I feel like there are two main responsibilities a writer should take on. One is to constantly question yourself, not to get complacent with the idea that you’re a good or worthwhile person or your work is good – everybody’s a good person in their own head. It doesn’t necessarily mean your views are the right ones. Self-improvement and self-examination is an ongoing process. There’s never a point when you can stop – as soon as you stop trying to improve yourself, you start turning into a worse human being. That’s not so much a political responsibility as a personal one, although the personal feeds into the political.
The other responsibility, as I see it, is to recognise the power of narrative in the world and acknowledge your contribution to shaping that narrative. I’m of the opinion that narratives have a frightening amount of power when it comes to shaping and controlling human behaviour. Every Presidential race is a narrative. We go to war based on narratives. Currently, narrative seems to be waging a war against empirical evidence, and narrative is winning. We think we’re immune to these stories, but all the time they’re working on us on very deep, subconscious levels that can be very difficult to notice or admit to ourselves. So I think there’s an argument to be made that it’s worth keeping an eye on which narratives you choose to throw your weight behind, whether it’s the weight of a massive global media empire or just the weight of a single comic story.
I’m not saying that the narratives I choose to believe and support are the only narratives that should be believed and supported, although obviously as a fallible meat beast I do secretly think that. But it’s important, when you say something in print, to consider everything you’re saying. Because if you don’t give your work that sort of consideration – if you’re thoughtless, in other words – then you end up putting things into print that can perhaps come back to gnaw at you later. I’ve seen that happen more than once recently – I’ll be reading a story I’m loving, by people I love, and there’ll be a sudden swerve into something that makes me deeply uncomfortable in a way that doesn’t seem to have been intended.
As in, to create a very basic example: we have a story about Hero X – Hero X does something unconscionable – nothing at all comes of it and we leave the story feeling as though we’re expected to applaud Hero X. As opposed to: story about Hero Y – Hero Y does something unconscionable – we leave the story presented with a clear understanding that Hero Y has sinned and as such we do not feel obliged to feel the same way about them as when we started. Option 1 tends to be the result of people either having different definitions of what’s ‘unconscionable’ or – and this is the point I’m making – not thinking.
(Sometimes the line between the two blurs a little – a creator might intend option 2, but end up doing something that smells of option 1 because they couldn’t pull it off. Or the creator does option 1 but the reader sees option 2, or vice versa. Sometimes a creator will do option 1 and then another creator will take over and turn it into option 2, or vice versa. Intent is a complex creature (but not a magic one.))
Obviously, I’ve done this myself. It’s so easy to do. All you have to do is not think for five minutes in the middle of a nasty deadline and suddenly you’re bullying Susan Boyle in print. Suddenly you’ve accidentally made an artistic statement to the effect that the entire concept of penal rehabilitation is a load of politically correct wank for useless hippies. (Both crimes I feel I’ve committed, and which I could have caught earlier and done something about.) There will always be things that slip through, but it’s best to be as in control as you can be of what your story ends up saying.
And one more thing – “it’s only a comic” is bullshit. If nothing else, I’ve got too much respect for the medium to denigrate it just to cover my own ass, as a reader or a writer.
SMITH: I remain fascinated by “Damnation Station”, and I’ve missed the strip since the first book concluded. Were you pleased with it? What did you learn from the process, and is it a strip which you’d like to do more of?
EWING: I wasn’t pleased with myself about it at the time – I felt like I’d let myself down and hadn’t hit the lofty target I’d painted for myself, which was to do something on the level of a great European bande dessinee. And of course, at the same time I was straining to make this amazing thing that would change comics, I was also having fun with Zombo, and obviously Zombo became the big thing because I was grooving rather than straining. (And now, with Zombo 4, I’m straining. Sigh. I should learn something.)
Anyway, I’m actually sitting down now and writing the first episodes of the second (and final) book, and I’ve read back through the first series for the first time since it came out – and suddenly, I’m really happy with it. I think it’s great. All the little things that made me fall out with myself the first time around just don’t seem to matter so much. There are still some problems with it. It’s not my best work in terms of storytelling – June’s story is told entirely in hints and background, and while that’s nice in a way, there were better ways to do that.
In the end, I’m proud of it. There are a lot of nice touches – the alien language I invented and never translated, which is maybe a bit of cleverness I relied on too much in place of actual characterisation, but it made for some nice sequences where I had to think out how to tell the story without any dialogue that a reader could possibly comprehend without effectively breaking a secret code. (Based on what I learned there, the next major Dredd strip I do will probably have a lot of untranslated French.) The sex-positivity, I’m very proud of – the way characters fell in love and into bed without really announcing it to the reader. The way Brett’s betrayal of Jim was as important, as large a catastrophe, as the station being blown up. I feel like people felt real in a way they hadn’t so much before in my work.
I suppose looking at the work I’ve done since, I was trying out a lot of ideas and techniques that I got a lot more proficient with after the fact, which is good news for Series II – I’ve included the fact that there was such a long gap in the continuity, so hopefully the divide between the me of now and the me of then won’t seem so huge and odd.
SMITH: You’ve worked with the superhero’s pulp predecessors in your novels, and referenced aspects of the super-book’s tradition there too. (Or at least I think you have!) Does the super-hero interest you as a writer? Part of what I enjoy about your work is the diversity of forms you work in, but is there a place for a super-hero in your work?
EWING: I’d love to do super-hero work sometime. I think it’s a fine genre, and one that seems to mingle fairly well with others. I don’t think there’s anything inherently wrong with it – I’m not one of those people who hates super-heroes, although I like Batman better when he’s solving strange Borges-inspired mysteries with his friends in the Club Of Heroes, as opposed to just being really rude to people and torturing them and talking in a silly voice about how “the Occupy movement is awful, just awful, why don’t these people have jobs. Hhhh. I’m Batman.”
But that’s the nice thing about Batman – it’s a character that can be anything. I’m a Batman: The Brave And The Bold sort of person myself.
That said, I’m still working out how I feel about the way super-heroes have been farmed over the years. I’ve been doing a lot of thinking about that. Right now, if it was up to me, I’d probably rather work with either a public domain super-hero – for the historical heft – or build one out of whole cloth. (Is there any whole cloth left with superheroes? Would it be a Frankenstein of a thousand different analogues? Whatever, that could be fun.) I think I’d have more freedom that way. And if I invented it, I could own it. Which would mean working outside the established structures.
What I’ve been increasingly thinking of is a super-hero universe in a bottle. One comic, anthology format, all in the same continuity. If I could find a way to get Henry Flint and Boo Cook involved, that would be ideal. Henry Flint inked and coloured by Boo Cook. Can you imagine? Can you conceive of what that might look like? I can’t, but I know it’d be good.
Tom Scioli seems to be moving in this direction at the moment, but I definitely think there’s room for more people to be thinking like this, and I feel like it’s an approach to the genre that makes sense.
SMITH: Jennifer Blood seems to me to be a minefield of a property, in that it plays with taboos which some folks will, I fear, inevitably perceive in a facile if not hostile way. How do you approach such a project? Where do the boundaries lie as regards the things which you will and won’t show? (What would be an example of eyeball popping, for example, which wouldn’t get into your scripts?)
EWING: Good question. There’s not much I won’t show in terms of physical violence. There are ways to make violent scenes very comedic, or very disturbing, and I’ll go for whichever one suits the intent of the story. For Zombo, the violence is very Tom and Jerry, very comedic, but as JB is set in a much more reality-based world, the violence there should be harder to take. Any chuckles coming from that direction are very dark. Whistling past the graveyard.
Violence against women I try to be a lot more careful with – I don’t want to titillate people with that, or play it for laughs, and I’m very conscious that I need a story in place that’s going to be able to take the weight of it. Again – there are things you don’t want to accidentally imply are okay, and that’s one of them.
By the time it crops up in Jennifer Blood #15, everything’s taken a much more serious turn – I kind of wanted the reader to get more and more uncomfortable with Jen as the series went on, and maybe question a couple of the things that they’d cheered her on about before, so Emily’s death is particularly unpleasant and undeserved. I don’t tell any jokes about it, or imply that it’s a good thing. It’s something horrific and deeply traumatic for anyone in the book who isn’t seriously damaged. Anyone who can read Jennifer Blood #15 and think that Emily got what was coming to her is getting that from their own twisted impulses, not from my writing. So I feel like I’ve done my job in that regard.
My feeling when I read Garth’s original scripts – and he was probably much more subtle about putting this across than I have been – is that Jen wasn’t really any better than her evil Uncles. I mean, her uncles were so horrible, so utterly irredeemable, that it was relatively easy to think of her as the heroine, or at least not the villain, while she was up against them. But as soon as that battle is over, and all the loose ends of that tied up, we find ourselves left with the story of this… sociopath, this woman who drugs her own five-year-old, six-year-old children in ways that could seriously hurt them, so she can run off and make letters out of intestines. Even during Garth’s run, Jen was a monster. I just made that part of her more obvious, and waited for the readers to see her as I did. I don’t think she’s ever acted out of character – the way I read her character from Garth’s original run, at least. Writers coming after me might disagree, but we’ll see what happens when that happens.
SMITH: Finally, what can I help plug for you?
EWING: Glad you asked! I have a new Dredd story coming up in 2000AD that is a must-read for everyone. Jennifer Blood is still ongoing and moving further into new territory, and I’m currently hard at work on a novel, The Fictional Man, that will be out from Solaris in 2013.
SMITH: Thank you!
Of course, the plugging ought to be far more comprehensive than that. IDW will be publishing The Zaucer of Zilk in two issues in October 2012, while Dynamite’s Jennifer Blood: Beautiful People is just out, with The Ninjettes scheduled for a collected edition in December. Rebellion published the first Zombo collection – Can I eat you please – in 2010, with the next one – You Smell Of Crime And I’m The Deodorant – scheduled for late 2013. There is also a Ewing tale in Judge Dredd: Tour Of Duty – The Backlash, while Abbadon Books, who’ve published seven of Mr Ewing’s books, have a look at his author page here.

domain: literature


text:
#1 Jack the Ripper: The Unidentified Madman
One of the most remorseless killers of all time doesn’t have a name or a face. In 1888, an unidentified man terrorized the streets of London. He lured his victims (mainly prostitutes) into dim corners and slit open their throats and disfigured their bodies.
The killer allegedly sent dozens of letters to the police mocking at their inability to catch him. He took his final prey in November 1888, after disappearing forever. The file was finally shut close in 1892, leaving a big question mark on his identity that continues to appear through generations.


text:
Toronto’s Wealthiest Family Became $8 Billion Richer Since The Pandemic Started
The last nine months have been challenging for many, but for Toronto's richest family, it was a time of financial growth.
The Thomson family, whose net worth currently sits at $39.6 billion, made several billion more since April 2020, according to Forbes.
Thomson family's reported earnings since April 2020
The Thomson family is known for being a leading force in the media and publishing worlds.
The Thompsons own a number of media companies, including Reuters, Bell, and The Globe and Mail. They are also in partnership with TorStar.
The most visible parent company of the Thomsons' is Thomson Reuters, a $35-billion global digital media empire.
63-year-old David Thomson, who inherited the title of Baron Thomson of Fleet from his father, is the chairman of Thomson Reuters. He also collects original Picasso paintings, according to Forbes.
The pandemic era has been lucrative for the world's wealthiest billionaires. In fact, $1.8 trillion was earned by the world's 500 richest people throughout 2020.
By lunchtime on the first working day of 2021, Canada's top CEOs made what the average worker would earn in an entire year.
- Top Earners In Canada: Here's How Much The 1% Make - Narcity ›
- These Are The Richest People In Canada In 2022 & How They Made Their Billions - Narcity ›
- Canada’s Richest Billionaire Is From Ontario & She's Even Wealthier Than Oprah - Narcity ›
- The 9 Richest Billionaires From Ontario In 2023 & How They Made Their Fortunes - Narcity ›

domain: economics


text:
Helping Health Professionals (HHP) and HHP students are among the highest risk occupational groups for compromised mental and physical health. There is a paucity of information regarding preventive interventions for mental and physical health in this group of healthcare providers.
Objective: The objective of this review was to examine the effectiveness of yoga interventions for the prevention and reduction of mental and physical disorders among HHPs and HHP students.
Design: An exhaustive systematic search was conducted in May 2020. Databases searched in the OVID interface included: MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily, Embase, and PsycINFO. EbscoHost databases searched included: CINAHL Plus with Full Text, SPORTDiscus with Full Text, Alt HealthWatch, Education Research Complete, SocINDEX with Full Text, ERIC, and Academic Search Complete. Scopus was also searched.
Results: The search yielded 4,973 records, and after removal of duplicates 3197 records remained. Using inclusion and exclusion criteria, titles and abstracts were screened and full text articles (n = 82) were retrieved and screened. Twenty-five studies were identified for inclusion in this review. Most frequently reported findings of yoga interventions in this population included a reduction in stress, anxiety, depression, and musculoskeletal pain.
Conclusion: It is our conclusion that mental and physical benefits can be obtained through implementation of yoga interventions for HHPs and HHP students across a variety of settings and backgrounds. However, researchers would benefit from following recommended guidelines for the design and reporting of yoga interventions to improve study quality and rigour.
Keywords: Healthcare professional students; Healthcare professionals; Mental health; Physical health; Systematic review; Yoga.
Crown Copyright © 2021. Published by Elsevier Ltd. All rights reserved.