SEC has now published, in Federal Register, the final rule adopting recordkeeping, reporting, and notification requirements applicable to security-based swap dealers (SBSDs) and major security-based swap participants (MSBSPs); securities count requirements applicable to certain SBSDs; and additional recordkeeping requirements applicable to broker-dealers to account for their security-based swap and swap activities. Earlier, in September 2019, SEC had announced that it took a significant step toward establishing the regulatory regime for security-based swap dealers (SBSDs) by adopting a package of rules and rule amendments under Title VII of the Dodd-Frank Act. The final rule will become effective on February 14, 2020. The compliance date for the rule amendments and new rules is 18 months after the effective date of any final rules addressing the cross-border application of certain security-based swap requirements.
Under these rules, the entities will be required to create and retain fundamental business records to document and track their operations, facilitating the Commission's ability to monitor compliance and reducing risk to the market. The cross-border rule of SEC has been amended to permit foreign SBSDs and MSBSPs to avail themselves of substituted compliance to satisfy the recordkeeping and reporting requirements. The final rule addresses seven key areas:
- They establish record making requirements for SBSDs and MSBSPs and amend the existing record making requirements for broker-dealers to account for their security-based swap activities.
- They establish record preservation requirements for SBSDs and MSBSPs and amend the existing record preservation requirements for broker-dealers to address records relating to their security-based swap activities.
- They establish periodic reporting and annual audit requirements for SBSDs and MSBSPs and amend the existing reporting requirements for broker-dealers to account for their security-based swap activities.
- They establish early warning notification requirements for SBSDs and MSBSPs.
- They establish security count requirements for SBSDs that are not registered as broker-dealers and do not have a prudential regulator (stand-alone SBSDs).
- They amend the existing cross-border rule of SEC to provide a means to request substituted compliance with respect to the recordkeeping and reporting requirements for SBSDs and MSBSPs.
- They amend a rule that permits certain SBSDs that are registered as swap dealers and predominantly engage in a swaps business to comply with CFTC requirements in lieu of SEC requirements. The amendment adds the recordkeeping and reporting requirements being adopted now to this alternative compliance mechanism.
Effective Date: February 14, 2020
Keywords: Americas, US, Banking, Securities, Swaps, SBSD, MSBSP, Dodd-Frank Act, CFTC, SEC
The Australian Prudential Regulation Authority (APRA) released an update on the timelines for revisions to the market risk prudential standards and the implications for the broader capital framework.
Three global standard-setters launched a joint consultation that reviews the margining practices during the COVID-19 pandemic and identifies potential areas for further policy work.
The Bank of England (BoE) published the Statistical Notice 2021/09 requiring additional information from firms and software vendors to assist in the onboarding and testing phases for migrating statistical reporting to the BEEDS portal.
The European Banking Authority (EBA) published the final draft regulatory technical standards on gross jump-to-default amounts and on residual risk add-on under the Capital Requirements Regulation or CRR.
The Financial Conduct Authority (FCA) published the final rules on the Investment Firms Prudential Regime (IFPR) to streamline and simplify the prudential requirements for solo-regulated UK firms authorized under the Markets in Financial Instruments Directive (MiFID).
The European Supervisory Authorities (ESAs) have delivered to the European Commission (EC) the final report on the draft regulatory technical standards for disclosures under the Sustainable Finance Disclosure Regulation (SFDR).
The European Banking Authority (EBA) published an advice to the European Commission (EC) on funding in resolution and insolvency as part of the review of the crisis management and deposit insurance (CMDI) framework.
The Financial Stability Oversight Council (FSOC) released a report in response to the U.S. President's Executive Order on climate-related financial risk.
The Bank for International Settlements (BIS) published a paper that examines the business models and the associated risks posed by big technology firms foraying into financial services sector.
The Bank for International Settlements (BIS) announced the development of an Asian Green Bond Fund, in collaboration with the development financing community, to channel global central bank reserves to green projects in Asia Pacific.


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Beginning and novice writers fall prey to this clever little deceiver when they suddenly realize that they hadn’t included any details in a scene. They start popping them in without thinking about their placement or they rush back during a rewrite and drop them in like they are sprinkling in raindrops. These haphazard details smear across the page and take the characters hostage at knife point to completely stop the story. Here’s a scene I see way too often:
Mary jumped out of the car and ran into the house. The little two-story cottage style abode had a white picket fence surrounding it. The lawn had been cut two days ago, and already it showed signs of needing to be watered. Shelby barked at Mary as she unlocked the door with one of the many keys on her key ring. She had about 10 on the loop, but the house key was the only golden one. Inside, the hallway was dark, despite the bright day outside. She flipped on the light and rushed inside. The new carpet squished beneath her feet. The hallway still smelled of fresh paint. A breeze, as if a window had been left open, pressed against her warm skin. She noticed a coffee cup sitting on the low table in the middle of the living room. With a shock, she noticed someone was in there, sitting casually in the recliner. She entered the room. The ornate room had red carpet that hadn’t yet been replaced. As a child, her grandmother had never let her play in the room and had hardly used it herself, so the carpet was hardly worn. All her grandmother’s nick-knacks remained on the fireplace hearth just in front of the mirror in which she could now see the reflection of the man sitting in the room. A lamp was on beside him, shining onto a book he’d pulled from the shelf beside the fireplace. He slammed it shut as Mary entered the room. The sound made her jump.
Okay, well, that’s a start. But there’s a lot that needs work. Let’s start at the top.
Mary first gets out of the car and runs into the house. Then, it’s like she backs up in reverse so we can see not only the house, but the white picket fence, the lawn, the dog, and the keys. Not only has that stopped the reader, but it’s made the reader go backwards too.
Remodeling the house might be important, especially in light of the room that Grandmother left pretty much untouched — it was a show room, one reserved for company and special occasions and otherwise not used. I got that from writing this. Did you get that sense from reading it? Possibly not. So there were thoughts of the author that the reader might not get.
Then, we have the stranger in the room. Did you notice how even after she’d realized that someone was in the house she still reflected on the carpet, the nick-knacks, and the lamp without having a reaction to him. In fact, Mary doesn’t react at all until he slams the book closed. Let me ask you: if you came home to discover a stranger in your house, would you think about these things or would you be dialing 9-1-1 already? Yeah, let’s not make our characters do things we ourselves wouldn’t do (unless there is a very good reason for it, like she knows the cops are right behind her already).
Do you also see how the details of the story are listed like facts? Starting with the keys, in describing that she has 10 of them on her ring, right on the lamp. The story has pretty much stopped in this time, except for her turning and realizing that someone is in the house — that’s the only action. All the rest are details that have stopped the story.
So, now let’s fix this:
Mary pulled the car to the curb outside of her two-story cottage style house. She pushed her way through the gate of the white picket fence, reaching down quickly to pet Shelby as he barked a greeting to her. Mary riffled through the multiple keys on the ring for the golden house key and unlocked the door. Through the darkness of the hallway, the scent of fresh paint greeted her. She flipped the light and as she turned, she noticed a coffee cup sitting on the low table in the living room. A soft breeze drifted across her face as if someone had opened a window. Her heartbeat quickened as she stepped toward the room. The new carpeting squished beneath her shoes, dampening the sound of her movement. As she drew closer, she saw a black hole on the shelf where a book had been removed from the others. She scanned quickly to see if anything else in the room had been disturbed. All of her grandmother’s nick-knacks were lined up perfectly across the fireplace mantle. She looked up into the mirror above the fireplace which reflected the rest of the room and saw him. The stranger’s eyes locked with hers. He sat in the recliner, the book in his hands. He slammed it shut, making Mary jump, as he made to stand.
First we see Mary making her way from the car to the house. We show the reader the house from the vantage point of the car and move her through the fence and into the yard. Gone now is the state of the grass — it’s not important to the scene. The dog stays, because the dog is a state of normalcy — she’s expecting to see the dog and since the dog isn’t freaking out about someone being inside the house, the reader doesn’t expect it and must wonder how someone got passed the dog. This creates suspense.
Also notice in the first example how things are separated from the rest of the story: hallway was dark, carpet squished, fresh paint smelled, etc. All these things are independent sentences on their own. But in the second example, I’ve actually blended these things into the scene. They are no longer facts being told, but have a reason for being in the story: the carpet dampens the sound of her walking, the hallway is dark to bring on a sense of foreboding, the odor of the paint greets her in another warm gesture to make her feel safe in opposition to the dark hallway. Even the items in the room are no longer facts, but clues as she discovers the stranger in her house.
I did take out the whole part about the house being her grandmother’s. It probably is important, but not here. What’s important here is Mary returning home to find a stranger.
Any time you have details in your story that are standing alone like facts being shouted from a textbook, find a way to blend them into your story. If you don’t, they stop the story.
If you’d like another example of this, check out my chapter on narrative in The Write Edit.
Until next time, happy writing.

domain: literature


text:
The creative drive that spawns unique musical voices are the lifeblood of the Canadian Jazz Scene! Generation NOW features some of today’s most important Canadian jazz musicians. This group is carefully assembled to create a band that will not only relish in great time feel, but give you, the listener, a canvas of true original canadian musical personalities. Stacked with seasoned, award winning composers and brilliant performers, Generation NOW is a snapshot of a once in a lifetime event featuring Petr Cancura and Michael Blake on woodwinds, Rebecca Hennessy on trumpet, Marianne Trudel on piano, Rémi-Jean LeBlanc on bass and Greg Ritchie on drums.
Please note that the venue for this performance on March 13 has changed from the Azrieli Studio to the NAC Fourth Stage.

domain: artistic


Mission Prerna Channel is an initiative of Basic Education Department, Uttar Pradesh to bring all stakeholders of the Mission on a single platform and share all updates to achieve the goal of Prerak Pradesh by March 2022.
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- 🇮🇳🔫UP Police Online Question GK,GS,HINDI,SCINCE,....🇮🇳🔫@uppcivil
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Just four days after Frank Darabont dropped out of Universal Pictures' Snow White and the Huntsman prequel, The Huntsman, the studio has found a replacement director in VFX specialist Cedric Nicolas-Troyan. Insiders claim that Cedric Nicolas-Troyan was one of the top contenders to helm the sequel when the studio was first looking for a director, since he is very familiar with this story after serving as the visual effects supervisor on the 2012 original.
We reported last week that Emily Blunt is in talks to play the villain, and while Variety reveals that the actress is still in negotiations, her character has not been revealed. Snow White and the Huntsman stars Chris Hemsworth and Charlize Theron are reprising their roles as The Huntsman and Ravenna, with the story to reveal how both characters' fates intertwined before they met Snow White.
Frank Darabont wrote the most recent draft of the screenplay, with earlier drafts written by Craig Mazin and Evan Spiliotopoulos. Joe Roth is producing with Palak Patel serving as an executive producer. It isn't known when production may begin, but Universal has already set an April 22, 2016 release for the sequel. Cedric Nicolas-Troyan signed on back in October 2013 to direct the Highlander reboot for Summit Entertainment, and he is also developing Bethlehem for Universal.

domain: news


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2012 Oscar Nominated Animated Shorts
Wild Life - Directed by Amanda Forby, Wendy Tilby
Wild Life is a just over 12-minute short film set in 1909 that tells the story of an Englishman who relocates himself to Alberta determined to become a rancher, though the film also features titled dialogue that compares the Englishman's existence to that of a comet.
Wild Life is a quietly poignant film possessing a low-key melancholy that likely fits the experiences of this dignified man as his life on the frontier bares no resemblance to that described in the letters he writes home. The film is the only one of this year's animated short nominees to feature spoken dialogue, though it's the film's fluid brush-stroked animation that leaves the strongest impression.
The film is directed by veteran short filmmakers Amanda Forbis and Wendy Tilby, and in addition to its Oscar nomination the film has picked up nominations for a Genie Award and an Annie Award.
Odds of Winning: 4-1
Dimanche/Sunday - Directed by Patrick Doyon
Patrick Doyon's Dimanche/Sunday is a 9-minute journey through the imaginative mind of a child whose Sundays aren't nearly as eventful as what goes through his mind. Forced to attend church and then visit with his grandmother. While these visits are rather bland and predictable, the lone child creates his own absurd and magical fantasies throughout the day.
The second of two entries for Canada's National Film Board (Wild Life is also an NFB film), Dimanche is easily the weakest and least satisfying of the 2012 Oscar nominees and pales in comparison to multiple animated shorts reviewed by The Independent Critic this year. While its watercolor animation with its muted tones is well done, there's really not much with the film that draws you in or even encourages you to keep watching even at a slight 9-minute running time. Considered a French language film, the film actually more features mumbles than actual communication.
Films that go this absurdly should be far more enchanting, and the life of a lone child on a Sunday morning is filled with both comical and dramatic possibilities that never manage to enter the picture here. Dimanche isn't a bad film, but it's difficult to fathom that anyone considered this one of the top five animated shorts of 2011. The film did win Best Short Film at the 2011 Berlin International Film Festival and has also picked up an Annie Award nomination this year.
Odds of Winning: 25-1
A Morning Stroll - Written and Directed by Grant Orchard
While I wouldn't dare call Grant Orchard's Oscar nominated short film A Morning Stroll my favorite of the films nominated in the category of animated short this year, it is unquestionably the film that elicited the strongest response - mostly laughter. The 9-minute film takes place in the years 1959, 2009 and 2059 and wraps itself around a variation of the whole "chicken crossing the road" storyline, but in this case we get a street smart chicken and a not so street smart New Yorker.
Winner of Best Animated Short at the 2012 Sundance Film Festival and also nominated for a BAFTA Award, A Morning Stroll is said to be inspired by a short story by Linda Elegant simply titled "The Chicken." Orchard's equally short film expands upon Elegant's concept by having the chicken journey from the simple times of 1959, complete with a very retro-styled animation that is beautiful to behold, to a post-apocalyptic 2059 that is more vibrant and gothic in its presentation.
As I was watching the early moments of A Morning Stroll, I found myself thinking what a lovely companion piece it would be to this year's silent film The Artist, but by the time the film has wound down it becomes clear that Grant Orchard has taken this film on a unique journey all its own.
Odds of Winning: 7-1
La Luna - Written and Directed by Enrico Casarosa
It should come as no surprise that the folks at Pixar, who failed to land an Oscar nomination for Cars 2 this year, have managed at least to salvage their stellar reputation by snagging a short film nomination with La Luna, an almost 7-minute meditative short that features what is arguably the best animation among this year's nominees in the animated short category.
La Luna is a coming-of-age fable about a young boy growing up in most unusual circumstances. The film takes place on a very special night when the young boy will join his father and grandfather in the family's very unique line of business. In a year where Pixar did the unthinkable and came off as a more commercial-minded studio rather than a critical darling, La Luna is a reminder of just how wonderful a Pixar film can be when all the magic is there.
Pixar has always had a knack for celebrating the wonders of childhood with respect and innocence, a knack that seemed lost in Cars 2 but one that is in full force here. Given the studio's resources, it's no surprise that the film is an animated marvel. Can it take home the Oscar this year? If the Academy wants to recognize Pixar despite their Cars 2 debacle, then this may give them the opportunity and it may slide into the winner's spot that should more rightfully go to The Fantastic Flying Books of Mr. Morris Lessmore.
Odds of Winning: 3-1
The Fantastic Flying Books of Mr. Morris Lessmore - Directed by William Joyce, Brandon Oldenburg
Easily the best of the 2012 Oscar nominees for Best Animated Short Film, The Fantastic Flying Books of Mr. Morris Lessmore is a beautifully constructed, poignantly written tale that pays equal tribute to Buster Keaton, Wizard of Oz, silent films and glimpses of real life into what should unquestionably take home the golden statuette this year.
Co-directed by William Joyce and Brandon Oldenburg and penned by the award-winning author/illustrator Joyce, this is one film that is absolutely mesmerizing from beginning to end. The only tragedy would be watching it at a film festival where you couldn't sit there and watch it again and again and again.
The Fantastic Flying Books of Mr. Morris Lessmore is based upon an e-book and is the most emotionally resonant and entertaining film of this bunch. Every aspect of the film's production is incredibly well done including John Hunter's marvelous original music, Eva Contis's flawless editing and animation that manages to simultaneously feel retro in its style and contemporary in its magnificent use of technology and CGI.
Odds of Winning: Even
All Reviews by Richard Propes
Copyright 2012, The Independent Critic

domain: entertainment


The Wyoming Legislature passed on Thursday an abortion ban trigger bill, joining 12 other statehouses across the country that have put in place similar legislation. The measure still requires the …
The Wyoming Legislature passed on Thursday an abortion ban trigger bill, joining 12 other statehouses across the country that have put in place similar legislation. The measure still requires the signature of Gov. Mark Gordon.
House Bill 92 easily cleared the Senate on a 24-5 vote, though the Wyoming Legislature’s website did not list how the senators voted. The final version passed the house on a 45-14 vote, with all of Park County’s representatives supporting it.
The bill will be enacted if the Supreme Court overturns its decision on Roe v. Wade. That possibility has become more likely as the high court has moved to the right.
The new legislation, if ever enacted, would severely restrict abortions, providing exceptions only when carrying a child to term would pose severe health risks for the mother or if the pregnancy is the result of rape or incest.
Previously, the bill did not allow exceptions for circumstances involving rape or incest. An amendment by Sen. Cale Case, R-Lander, providing for these exceptions passed by a close vote Wednesday. A nearly identical amendment proposed by Rep. Mike Yin, D-Jackson, had previously failed in the House.
Even if the Supreme Court changes its decision, a new ruling on Roe v. Wade may not be cut and dry. Several legislators pointed out this potential ambiguity as a concern.
“The vagueness will kill us because, Mr. President, we don’t know what the Supreme Court decision will say,” Case said.
A statement from the ACLU also said that “House Bill 92 provides no definition of what the Legislature considers a “final decision of the Supreme Court.”
“Regardless of how the Court rules in any of the currently pending abortion cases, it is without doubt that the fundamental rights at issue in Roe as they relate to abortion will not cease to be litigated on federal and state levels,” the statement said.
Case has also argued against the bill on the grounds that it would involve the state in individuals’ private medical decisions.
“Make no mistake, this bill tells women what they have to do with their bodies, it’s a form of bondage, Mr. President, to have the state be in control of these very intimate, personal, private decisions,” he told his colleagues. “And all we’re saying is that the Supreme Court is going to magically take over and be the basis for Wyoming law.”
The bill states that an abortion ban will be enacted “five days after the date that the governor certifies to the secretary of state that the Supreme Court of the United States has overruled Roe v. Wade” in a manner that would authorize the bill’s abortion ban.
The ACLU raised concerns about the ambiguity of putting in place such legislation when a Supreme Court decision may be unclear and said it “improperly delegates legislative power to the executive branch.”
“In assigning the executive branch the responsibility of enacting law based upon future hypothetical case outcomes, House Bill 92 is creating a codified, inflexible mandate that lacks clarity,” said ACLU of Wyoming campaigns director Libby Skarin.


Australia — A senior engineer questioned why a device to reduce the pressure on a power line was not fitted to the line that sparked one of Victoria’s fatal Black Saturday bushfires, a court has heard.
Former SPI Electricity senior lines engineer Anthony Walley said he noticed there was no vibration dampener attached to the power line, which failed and caused the Kilmore East blaze, while visiting the site shortly after the February 2009 bushfire.
Mr Walley told a class action over the fatal bushfire he asked a colleague why the device had not been fitted and was told “not to worry about it”.
He said a vibration dampener could reduce the load on a power line and extend its life.
Mr Walley, who no longer works for the company, also said it was concerning all maintenance data on SPI Electricity assets for the years before 1999 was missing.
He said it was important to know the history of an electricity asset, such as a power pole or line, to predict how much longer it could function.
The remaining SPI Electricity database detailing the condition of its assets was limited, according to Mr Walley.
“The records that were kept were not as complete as they could’ve been and in some areas were lacking,” he told the Victorian Supreme Court.
Victorian woman Carol Matthews is leading a class action of more than 10,000 people suing SPI Electricity, claiming it was negligent in failing to maintain power lines that sparked the Kilmore East blaze.
The Kilmore East bushfire killed 119 people and destroyed 1200 homes.
The group is also taking action against the CFA, Victoria Police and the Department of Sustainability and Environment over their failure to warn communities.
All defendants deny the allegations and are fighting the claims.
The trial is expected to run for most of the year.


South Side football preview: Rams have plenty to replace former star AJ Crider
More than anything, South Side football's identity last year was shaped by AJ Crider. One of the best players in the WPIAL, Crider ran for 1,362 yards at fullback and accumulated 57 tackles and four sacks at linebacker last season.
Crider is gone now, off at Toledo to play linebacker, leaving the Rams with a lot to replace. With Crider leading the way, South Side went 4-6, losing in the first round of the WPIAL playoffs to Washington. Making the playoffs is the goal once again, and to get there, it will take a team effort.
“We don’t have a Crider. He was a stud. He was able to make up for some things. We don’t have that," second-year coach Luke Travelpiece said.
With a Week 0 matchup against OLSH looming on Aug. 26, Travelpiece has been impressed with his team's work ethic, to the point that he called them his most dedicated team in the five years that he's been at South Side as an assistant and head coach.
“The thing I’m excited about is these guys are a really good group of hard workers who want to excel," Travelpiece said. "I think that’s going to carry us. I think you’re going to see us look a lot more like a traditional South Side team.”
South Side's offense last year was very much shaped by Crider. The Rams run a wing-T offense, which typically doles out 60 percent of the carries to the fullback and 40 percent of the carries to the wingbacks, Travelpiece said. Because Crider was at fullback, he got roughly 70 to 75 percent of the carries.
"The offense ran through him.” Travelpiece said.
Along with Crider, South Side will be replacing it's two starting wingbacks and its quarterback. Jordan Bruce and Nathan Roy look to be the main contributors at wingback. Travelpiece said that Roy, a junior, has made exponential strides in the weight room and in his speed and agility.
Jake Botkin was Crider's backup at fullback last year, and will assume a starting role this year.
“We’ve got four new guys in the backfield. I haven’t done the stats yet (on how many yards we lose). I don’t want to, it will make me depressed," Travelpiece said.
Combined, South Side will lose 2,300 yards in the backfield. Still, Travelpeice likes what he's seen from the new starters.
"I’m really confident in our backfield. I think they’re going to be able to do their job," Travelpiece said.
At quarterback, Trenton Seik, Rigdon Doran and Derek Franchek are all competing for the job. Seik, a sophomore, played the last three quarters of South Side's playoff game last year. Doran played receiver last year.
If he doesn't win the quarterback job, Doran will likely slide back over to wide receiver. He'll be joined primarily by Brandon Bargerstock, a 6-foot-2 senior.
Up front, South Side graduated four starters, including two all-conference tackles. Seven players will compete for the five spots on the line.
The Rams play a 3-5 scheme, and graduated three of their primary contributors on the line. Josh Hillard, a junior, and Jake Navarra, a senior, both have playing experience and will play key roles on the line. Johnathan Olszewski will contribute, as will Jaelen Crider, AJ's brother who's a sophomore. Austin Reilly, a senior, also is in the mix, and Travelpiece had high praise for him.
"I really think he has the potential to be an all-conference down lineman," Travelpiece said. "It’s up to him and how he responds to that. The ability is there. He's an extremely strong, quick kid."
Travelpiece believes in the talent of the defensive line, but is hesitant to make any steadfast proclamations until he sees them produce in a game.
“I think they can do it. They’re strong, dedicated kids. They’ve got everything you ask for," Travelpiece said. "It’s just time to put the pads on and see it come to fruition.”
At linebacker, South Side loses AJ Crider and Cody Hample. Botkin, Nick Myak and Nick Weaver will look to replace those two. Botkin and Myak both saw time in the rotation there last year.
In the defensive backfield, Cole Campbell, an all-conference performer at free safety last year, graduated. Doran returns as a starter at strong safety, as does Anthony Navarra at corner. Jordan Bruce, a safety last year, will play corner this year, replacing Robby Heberle, who graduated.
Calli Grimplin will kick extra points and field goals, while Reilly will handle kickoffs.
Hample punted last year, and Devin Ross, a freshman, is his likely replacement. Ross had never punted before, but showed raw talent the first time he tried, punting the ball 40 yards.
The wingbacks will likely handle kick and punt returns.
The Rams are replacing a number of starters, which likely means there will be some growing pains along the way. Travelpiece, though, has confidence in this group, in large part because of their work ethic.
“We’ve got to hold onto the football this year," Travelpiece said. "We’ve got to hold onto the ball and control the clock and just have our guys execute.”


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APPLICATIONS OF RALTEGRAVIR
We are getting our first in-depth look at some of the
research behind raltegravir, a powerful therapy for multidrug-resistant HIV
infection already approved by the FDA. How is this raltegravir data impacting
current clinical strategies for attacking the virus in multidrug-resistant
patients. You are listening to ReachMD XM-157, The Channel for Medical
Professionals. Welcome to the Clinician's Round Table. I am your host, Dr.
Mark Nolan Hill, Professor of Surgery and practicing general surgeon and our
guest is Dr. Roy Steigbigel, Professor of Medicine and Pathology, Molecular
Genetics, Microbiology, and Pharmacologic Sciences and the founding director of
the comprehensive AIDS Center at the State University of New York at Stony
Brook. Dr. Steigbigel is the lead author of research on raltegravir published
in the New England Journal of Medicine.
Welcome Dr. Steigbigel.
Well thank you.
We are discussing this clinical applications of
raltegravir. Doctor for full disclosure you have served as an investigator for
Tell us a little bit about your background. How did you get
involved with this research, with this drug in particular?
Well I have been involved in HIV research before HIV was
discovered to be the cause of AIDS back in the early 80s when I was at the
University of Rochester, so I have been involved in numerous studies fairly
basic level and also at the clinical investigation level for new therapies and
this is a compound that I have been involved with since it was first used in
clinical trials, in fact, our center put the first patient in the world on this
And how specifically did you think to use this medication an
Well the advantage of this medication is as you state, it
inhibits the integration step in the virus' replication cycle and we have not
ever had a drug for that step in replication. That's an important point
because the incidence of resistant to HIV in individuals who have been on
therapy for years continues to increase. People do develop a resistant virus,
especially if they are not taking their medications regularly. Additionally
people who are newly acquiring virus, that is people who have never had therapy
before are acquiring virus from other people that is resistant to current
medications. So getting medications in a new class that is in a new step in
replication is really quite a breakthrough and this drug raltegravir does
represent that particular point.
In a very simplistic fashion and not thinking about the
resistant patients, is this a better way to approach HIV as opposed to the
standard antiretroviral treatment?
Well it is not necessarily better. It is not necessarily
better, it is better for those people who have resistant virus because the
chance of ever having virus resistant to it is very close to zero as there has
been no integrase inhibitor out there ever. So viruses have not developed
capacity to be resistant to raltegravir to this point. Of course, that does
not mean that viruses will not become resistant to it and in fact, in the
studies, a small number of people have already developed resistance to
Now you have studied for 48 weeks, I believe, the 2 clinical
markers of HIV infection, correct?
And not the clinical efficacy.
That's right, the studies that were published in New England
Journal of Medicine were not designed to look at clinical efficacy as the
length of time, i.e. 48 weeks, would not likely be able to detect any clinical
efficacy, so the design of the study, the proscribed design was to look at 2
aspects of HIV therapy which are clearly and unequivocally predictive of
clinical outcome, i.e. the drop in the viral load, the amount of virus people
have in their body and the increase in the CD4 cells, the cells that are
normally damaged and eliminated and become dysfunctional because of HIV. So in
the field of HIV research for new therapies, these 2 so-called surrogate
markers are accepted as predictive efficacy by the research community and more
importantly perhaps by the FDA.
To continue on this point, I am sure a lot of listeners are
thinking, the FDA certainly is a very particular organization and how a drug
can be approved without clinical studies is surprising, but I suppose it has to
do with what you just said, right?
Yes, it is because of study after study after study and just
basic information and knowledge about HIV indicates that the primary utility of
a drug will depend on its ability to stop the virus from replicating.
Unfortunately, none of the drugs we have cure. None eliminate virus, but they
bring the viral load down to very low levels, levels that are often referred to
How do you think this is affecting clinical practice at this
Well I think this is a breakthrough, in that for people with
highly resistant virus which was what this study was looking at, it offers an
opportunity for people who had very few options who are really going to have
major problems in the future, this offers a real turn for them to have periods
of time, how long we don’t know, but periods of time where their HIV can be
well controlled. Many people think it is analogous to what happened around 95
when we had the new class of drugs, i.e. the protease inhibitors.
If you have just joined us, you are listening to The
Clinician's Round Table on ReachMD XM-157. I am your host, Dr. Mark Nolan Hill
and our guest is Dr. Roy Steigbigel, Professor of Medicine and Pathology,
Molecular Genetics, Microbiology, and Pharmacologic Sciences and the Founding
Director of the Comprehensive AIDS Center at the State University of New York
at Stony Brook.
We are discussing the clinical applications of raltegravir.
Doctor, are we seeing a significant group of patients that develop resistance
directly to raltegravir?
There was a small group of people who on the raltegravir,
the study began just, was looking at people who received raltegravir plus
optimized treatment background versus placebo plus optimized treatment
background and in some there were a small number of people in the raltegravir
group who did develop resistant virus. They were people who had very few other
active drugs, so that as a single agent raltegravir and as any other single
agent will not be working very well. It needs to be taken in combination with
some other medications that have effect on the virus.
Now when we speak about only 1 genetic mutation is needed to
develop the resistance, what does that exactly mean?
Well, with raltegravir actually, its one major one plus
minor ones. So it is more than 1, what that means is in the enzyme which is
blocked by raltegravir, in this case integrase, the change in amino acids in
that enzyme can lead to the inability of the drug to block the integrase
function. For some medications, there is a requirement of virus to have
multiple amino acid changes and for others fewer. So raltegravir it seems at
this point a single mutation, a major mutation plus some other mutations along
with it can lead to resistance.
Is this problem of continuing resistance, is this going to affect
raltegravir and just continue on and also require more medications, different
medications in the future?
Most likely, while this is a breakthrough, it is not a
panacea for the resistance problem with HIV and that is why continuing look for
additional medications that act at other steps of viral replication inhibition
are needed. In fact, there are another class of drugs also recently approved
which operate in another step in the virus' replication cycle and they block
what is called CCR5 which is one of the places that the virus heads to latch on
to the host cell. So we do have these 2 truly new medications that have come
out in the last 6 to 8 months which represents really a breakthrough.
A general question, is there any way to combat the problem
Well the most important thing clinically is for us to
encourage our patients to take their medications very regularly, unlikely other
medications for infectious diseases, a skipped dose can lead to resistance
Why is that?
Probably because the virus has the great ability to mutate
and additionally because we haven’t cured the infection, the virus levels can
come up quite quickly and then resistance will occur. So HIV is a difficult
virus for many, many reasons, but among those reasons is the necessity for
keeping the viral load very, very, very low in which case the chance for
resistance is diminished, but never totally eliminated.
You have mentioned several times about being able to cure
the disease with this treatment. Will we be able to cure the disease at all in
Currently there is no way that we understand that this can
be cured, because in addition to the replicating virus, at a high level there
is virus replicating at a very low level or not replicating at all in resting
cells and none of the medications can get at that group of viruses or cells
currently. There have been methods that have been attempted to rid the body of
all virus, but so far they have all failed. So in the near future and may be
unfortunate longer term future, cure of HIV is not on the horizon.
Are there any patients who must stay away from raltegravir?
Well currently there is no identification of people who have
had any side effects or allergic reactions, but whether that will occur when it
gets to use in thousands of patients is unknown, but so far that has not been
Do you think that we eventually will see this as a first
line HIV therapy in nonresistant patients?
That's definitely something that is going to be looked at.
In fact, there are ongoing studies comparing it to other so-called first line
therapies to see if it as good or better than other first line therapies. So
those studies are ongoing.
Finally doctor, if you could look into your crystal ball, 5
to 10 to 15 years down the way, tell us what you see in terms of therapy for
Well I think what we have seen is a continuum of more
medications and better medications and simplified regimens. So while I have
been in this field since the early 80s, people were taking 15 to 20 to 25
medicine pills a day. We now have some regimens where people are taking 1 pill
a day which is combination therapy of several medicines. So I think we
continue to simplify and fortunately developing new medications for people who
have resistant virus. Hopefully that will continue, but at the same time, it
is likely that the virus will also continue to find ways to become resistant,
so we have to develop new medicines and of course the most important thing we
would all like to see is prevention with either vaccine which does not seem to
be in the near horizon, but also remembering that we do know how this virus is
transmitted and so methods to educate the human race about preventing
transmission is also very important.
I want to thank our guests Dr. Roy Steigbigel. We have
been discussing the clinical applications of raltegravir. I am Dr. Mark Nolan
Hill and you have been listening to The Clinician's Round Table on ReachMD
XM-157, the Channel for Medical Professionals. Be sure to visit our website at
www.reachmd.com featuring on-demand pod casts of our entire library. For
comments and questions, please call us toll-free at 888-MD-XM157 and thank you
This is Dr. Aron Karol, Director of the Center of Health
Policy and Professionalism Research in Indianapolis, Indiana and you are listening
to ReachMD XM-157, The Channel for Medical Professionals.

domain: biology


Iran rules out producing nuclear weapons although it can do so | News
The Government of Iran assured this Monday that they have the technical capabilities to build a nuclear bomb but, likewise, reiterated that it is not part of their plans to develop a project in this regard.
Iran says ready to end nuclear deal talks
The statements by the head of the Atomic Energy Organization of Iran (AEOI), Mohamad Eslami, come amid the deadlock in talks to revive the 2015 nuclear deal.
Eslami pointed out that the Iranian nuclear program is carried out under the supervision of the International Atomic Energy Agency (IAEA) and within the framework of the Nuclear Non-Proliferation Treaty.
We work closely with our JCPOA partners, in particular the Coordinator, to give another chance to the US to demonstrate good faith & act responsibly. As Iran, we stand ready to conclude the negotiations in a short order, the other side should be ready to do the same. 2/2
— علی باقریکنی (@Bagheri_Kani)
July 31, 2022
However, the head of the Iranian atomic energy regulation office denounced what he called the false accusations against Iran for its nuclear program and stated that they derive from Israeli intelligence statements, while recalling that in order to reactivate the agreement requires that the United States return to fulfill its commitments, abandoned when it unilaterally withdrew from the pact in 2018.
In turn, the chief Iranian negotiator before the agreement, Ali Baqeri, affirmed on Sunday that Tehran had transferred a counterproposal to recover the nuclear agreement to the High Representative of the European Union (EU) for the Common Foreign and Security Policy, Josep Borrell. “We have shared our proposals on substance and form so that a speedy conclusion of the Vienna negotiations can be achieved,” he said.
The Iranian authorities are currently negotiating with the signatory countries of the agreement and with Borrell to “give another opportunity for the United States to demonstrate good faith and act responsibly, Iran is prepared to complete the negotiations as soon as possible, if the other party is prepared to do the same,” he explained.
The European foreign policy chief said last week that a new draft had been submitted to Iran and the United States to revive the nuclear deal. Washington replied that it was studying the proposal and that it would respond to Brussels as soon as possible.
Iran has announced the withdrawal of its commitments on several of the points of the 2015 nuclear agreement after the United States left the pact unilaterally in 2018, however the Iranian authorities have defended that these steps can be reversed if the United States withdraws the sanctions and returns to the agreement.


Mayor signs ordinance allowing raw milk sales in Albuquerque
Mayor Tim Killer signed an ordinance Tuesday that allows raw milk to be sold in Albuquerque stores that opt to carry it. The state and Bernalillo County already allowed retail of the previously-controlled substance.
Raw milk is unpasteurized, meaning it has not gone through a process that helps kill harmful bacteria. The Centers for Disease Control and Prevention warns the product can make people sick.
The Albuquerque City Council passed the measure on a 7-2 vote last month. Keller’s Office said in a statement that his administration is, “committed to allowing consumers to make informed decisions when it comes to food.”
In a video posted to Facebook, the mayor said his nephew and sister-in-law were his inspirations for learning about raw milk and helping make it available at city stores.
Fiona Keller said her son Jackson Keller was born with profound diffuse bilateral brain damage.
"And when we were looking at the therapies to help him, one of the practitioners suggested that we try raw milk for its nutritional benefits," she said.
The Raw Milk Institute said those include enzymes, probiotics, fats, proteins, vitamins and minerals — similar to breast milk — that are inactive, damaged or “destroyed” in pasteurized milk.
Albuquerque stores that choose to sell it will be required to hold a raw milk permit from the city’s Environmental Health Department.


text:
As Sylvia’s childhood becomes a gentrified neighborhood, there remains some favorite local addresses.
The Williamsburg Bridge leads to a deli, a popular food court, an art library, and a hidden gem café.
A Danish variety store and an independent bookstore.
Herald Square is about “being a tourist in your own city.”
Thrift stores and Asian-inspired eateries make up East Village’s eclectic addresses.
Everything was happening so fast that there was no time to think beyond the present moment, and everything was new.
5 things you should own for your closet, inspired by Japan.
A host family feels like a simulation, like we were all playing into our respective roles even though we had just met.
It is a story told ad nauseam.


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A little nutmeg goes a long way. Try telling that, though, to the inhabitants of Western Europe in the late 1700’s who couldn’t get enough of the spice rumored to be an aphrodisiac — the Dutch fought a war in the East Indies just to maintain their monopoly over production and intentionally destroyed stockpiles to inflate prices back home. While it’s hard to imagine anyone today getting into such a fuss over a spice, it’s still a fairly expensive commodity — a two-ounce jar of whole nutmeg can easily cost $10.
What is it about nutmeg that makes it so valuable? Its unique flavor and aroma — spicy, pungent, and slightly sweet — pairs well with creamy dishes and drinks, such as béchamel sauce, eggnog, and creamed spinach. It is also often found in baked fruit-based desserts such as apple crumb pie, as well as curry blends. Best when freshly grated from the whole seed, nutmeg is a versatile spice used in many cuisines around the world. (Photo courtesy of Alberto Peroli)
Most nutmeg harvested today comes either from Indonesia or Grenada, a small island nation located in the Caribbean where the spice was so important, it was incorporated into the country’s flag. When the fruit is harvested from the tropical tree, the nutmeg seed is separated, protected by a colorful membrane which pops open at maturity. That colorful membrane is also processed into a valuable spice — mace. (Photo courtesy of flickr/smithysteads)
Extending the shelf life of nutmeg is fairly simple and straightforward. Store it in a dark container away from heat and humidity, and avoid freezing it; the condensation that forms when thawing can actually shorten shelf life. (Click here to see 8 Genius Ways to Store Canned Goods and Spices.) When cooking with nutmeg, it’s best to grate it in off the heat, to maintain flavor. Once nutmeg is grated, it begins to lose its essential oils, which give it the characteristic aroma and flavor, so avoid purchasing ground nutmeg; it may be cheaper, but it won’t be worth it.
So next time you’re having trouble pinpointing that extra special something in a dish, you might not know exactly what it is, but you can take a pretty good guess: It might just be nutmeg.
The Best Type of Nutmeg to Use In Your Baking (and everything else!)
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You know how you sometimes experience something and it instantly brings back a fond memory?
Like hearing an old song from a time when something really great was happening in your life.
Or smelling a scent that brings you back to a happy memory of someone from your past.
Or when you taste something that brings you back to your childhood and the simplicity of that time?
Nutmeg is one of those magical triggers for me.
Nutmeg is a taste that brings me back to my childhood. My mom makes something called &ldquosweet bread&rdquo and it&rsquos filled with delicious nutmeg flavour. And no, it&rsquos not that horrid sweet bread that comes from an animal. Rather, it&rsquos a sweet and nicely spiced nutmeggy, coconutty loaf that those from the Caribbean know very well. I&rsquove made it a few times myself, but there is no other sweet bread like my mom&rsquos sweetbread.
So, nutmeg. I love it. It&rsquos a warming spice and it&rsquos filled with flavour. It instantly transforms a regular recipe into a very special recipe.
I try to make it work in my recipes wherever it makes sense. The most convenient type to use is pre-ground nutmeg, but let me tell you&hellipif you use pre-ground nutmeg, you are losing out on a whole lot of flavour. Who knows when that nutmeg was ground? So much flavour has been lost.
So what is the best type of nutmeg to use in your baking if it&rsquos not the pre-ground stuff?
Buy the whole nutmeg seeds and grate them using a microplane or mini grater as needed for your recipes.
And remember, a little goes a long way which is why recipes never really call for that much. The seeds are inexpensive and can be found at most well-stocked grocery stores.
Try using nutmeg this way and you will notice a big change for the good in the flavour of your baking (and non-baking!) recipes. Such a tiny change will make a huge difference!
Some recipes to try with freshly grated nutmeg:
Hi! I’m Gwen and if you’re looking for easy-to-make, delicious plant-based and gluten-free recipes you’ll want to make over and over again, you’ve landed in the right place! Read more…
What's the Difference Between Nutmeg and Mace Blade?
Nutmeg and mace are sibling spices! Both mace and nutmeg are derived from the nutmeg tree, which is native to the Banda Islands and the Caribbean. The pit of the fruit that grows on the nutmeg tree is nutmeg, and the covering on the seeds of the fruit is mace.
While mace and nutmeg come from the same tree, they're very different spices. For one, nutmeg is a lot less costly than mace. That's mainly due to the availability of the pits versus the seeds of the fruit. Because nutmeg is so plentiful, recipes typically call for nutmeg as opposed to mace. Additionally, mace has a spicier, more intense flavor than nutmeg—in fact, mace is quite similar to black pepper .
What is nutmeg, and how can I use it?
Nutmeg is most often found in baking recipes for cookies and cakes, but you can also use it to spice up stews, soups, meats, fruits, and preserves. One of the most popular uses for nutmeg is on top of holiday eggnog. Nutmeg works well in recipes that also call for allspice, cinnamon, cloves, cumin, pepper, or thyme. Since it's such a versatile spice, nutmeg can be used in sweet and savory preparations. To get the most out of your nutmeg, purchase them whole and grate them fresh when a recipe calls for it. Typically, one whole nutmeg will yield two or three teaspoons of the spice.
Does nutmeg offer health benefits?
Like many spices, nutmeg offers several health benefits. Using nutmeg can help relieve pain or soothe indigestion. Nutmeg can also provide cognitive clarity and help to detoxify your organs and skin. The spice is also said to help with oral issues, reducing insomnia, and preventing leukemia.
How can I use mace, and does it offer health benefits?
Mace is another common baking spice most commonly found in doughnuts, cakes, and cookies. Like nutmeg, you can also use mace in savory dishes like eggs, sausage, stuffing, or veal. Though they're not the same, mace does pair well with the same spices as nutmeg. Mace also provides several health benefits. Incorporating mace into your cooking can help improve your digestion, bust stress, boost blood flow, and protect your kidneys. If you're feeling under the weather, mace can help alleviate cold and flu symptoms, too.
Are you ready to start using more mace and nutmeg in your kitchen? Slofoodgroup offers Whole Nutmeg from Sri Lanka and Sri Lankan Mace Blade . Check out our nutmeg recipes and mace recipes to see what you want to whip up first!
What are its traditional uses and health benefits?
Aside from its function in cooking or baking as a seasoning, calabash nutmeg has an array of traditional medicinal purposes. Categorized by some as an antimicrobial and a stimulant, it has been said to help with intestinal issues, and when ground into a powder, it can serve as an antiseptic applied to irritated skin. It has demonstrated effectiveness in preventing nausea, treating eye diseases, hypertension and hemorrhoids, and has even shown promising anti-sickling effects. Potentially beneficial for folks dealing with heart conditions, calabash nutmeg, which is a source of calcium, folic acid, and vitamins C and E, may reduce the risk of cardiovascular diseases by lowering cholesterol.
Food What is moringa? Everything you need to know about the superfood
While a spate of studies continue to come out on its holistic health benefits and medicinal qualities, calabash nutmeg has been used to treat a wide range of maladies by certain communities for centuries. In traditional medicine, when combined with Ashanti pepper in soup, calabash nutmeg has been used to control passive bleeding from the womb immediately after childbirth. It is also used as a remedy for relieving pain, inducing sleep and reducing fevers.
7 Incredible Nutmeg Benefits: From Inducing Sleep to Relieving Pain
Besides being an exotic spice, nutmeg is grouped under the category of aphrodisiacs, and in cooking, only small quantities - such as a little grating or a pinch of the ground powder - are used to make soups, meat gravies, beef stew, steaks, roulades, and even desserts. In India, it is more commonly seen in Kerala, probably being brought in during the ancient spice trade. The locals use it to flavour meat curries and desserts, while the flesh of the fruit goes into the making of pickles, chutneys and other condiments. The spice is also a regular feature in Mughlai cuisine, being used as part of the various masala mixes for the meat preparations. In Hindi, it is known as Jaiphal.
The nutmeg tree is also valued for its medicinal properties. The leaves and other parts of the tree are used in extracting essential oil as well as nutmeg butter, which are used for the purpose of beauty and have other health benefits. Nutmeg is packed with nutrients: minerals such as magnesium, manganese and copper and vitamins such as B1, B6, etc.
Curious to know more? Here's listing out the many benefits of nutmeg -
1. Relives Pain
Nutmeg contains many essential volatile oils such as myristicin, elemicin, eugenol and safrole. According to the book DK Healing Foods, "Its (nutmeg) volatile oils have anti-inflammatory properties that make it useful for treating joint and muscle pain." Just a few drops of the essential oil on the affected area can treat inflammation, swelling, joint pain, muscle pain and sores.
2. Helps Treat Insomnia
Nutmeg has a calming effect when consumed in smaller doses. Various ancient medicinal practices credit it for its sleep inducing and de-stressing effects. According to Ayurveda, you should add a pinch of nutmeg to a glass of warm milk and have it before sleeping. You can also add in some almonds and a pinch of cardamom for added benefits.
3. Helps Digestion
Nutmeg contains essential oils which have a carminative effect on our system. So if you are suffering from digestive issues such as diarrhoea, constipation, bloating or gas, a home remedy is to grate a pinch of nutmeg in your soups and stews, and have it. It will help in the secretion of digestive enzymes, bringing about relief, whereas the fiber content in nutmeg will help in bowel movement. It also helps in removing excessive gas from the system.(Looking for products to help boost your digestive health? Shop now!)
4. Brain Health
Nutmeg is an aphrodisiac, stimulating the nerves in the brain. It was commonly used as a brain tonic by the Greek and Romans during the ancient times. It is known to be an effective ingredient for treating depression and anxiety as its essential oil tend to ease fatigue and stress. "As an adaptogen, it can be both a stimulant and a sedative, according to the body's needs. In times of stress, it can help lower blood pressure. Conversely, it can lift your mood and acts as a tonic and stimulant, making it beneficial if you are recovering from an illness or are overtired," as mentioned in the book DK Healing Food. It is also known to help in concentration.
5. Treat Bad Breath
Bad breath could be a sign of toxicity in your system. Unhealthy lifestyle and improper diet can build up toxins in your organs. Nutmeg is touted to help in detoxifying the body, clearing out toxins from the liver and kidneys. Since its essential oils have anti-bacterial properties, it helps in removing bacteria from the mouth which are responsible for causing bad breath. It is commonly used as an ingredient for Ayurvedic toothpastes and gum pastes. The essential oil eugenol helps in reliving toothaches as well.
6. Gorgeous Skin
Nutmeg is a good ingredient for skincare because of its anti-microbial and anti-inflammatory properties as well as its ability to remove blackheads, treat acne and clogged pores. A common home remedy is to mix equal parts of ground nutmeg and honey, make a paste and apply it on pimples. Leave it for 20 minutes, and then wash with cold warm. You can also make a paste using nutmeg powder and a few drop of milk, and massage it into your skin before rinsing clean. It can be used in scrubs along with oatmeal, orange peel, etc.(For chemical-free beauty products, shop on SmartCooky!)
7. Blood Pressure and Circulation
Its high mineral content makes nutmeg a good ingredient for regulating blood circulation and pressure. It contains calcium, iron, potassium, manganese, etc., which are all essential for various functions in the body. Its stress reducing properties help in relaxing the blood vessels while keeping the heart functioning efficiently.
Note: Nutmeg should always be used in smaller doses whether in cooking or home remedies for treating various ailments. If used in larger doses, it can cause nausea, hallucination and palpitations.
This needs a long, lazy roasting, so enjoy the aromas as you get ready for the party.
Since 1995, Epicurious has been the ultimate food resource for the home cook, with daily kitchen tips, fun cooking videos, and, oh yeah, over 33,000 recipes.
Nutmeg bread makes a wonderful food gift.
1 1/2 teaspoon ground nutmeg
1 stick butter or 8 tablespoons or 1/2 cup, softened
1 teaspoon vanilla extract
1/2 cup chopped nuts (walnuts or pecans)
Whisk together to flour, soda and nutmeg in a bowl and set aside. In a separate bowl cream the sugar, butter, eggs and vanilla with a mixer. Combine the flour mixture with the egg mixture, add buttermilk and continue mixing. Stir in nuts. Spray a 9 x 5 baking pan with cooking spray. Add bread mixture and bake in preheated 350 degree oven for 1 hour or until center of bread tests done. Makes 1 loaf. Enjoy!
Note: You could add a glaze to the top of this bread or sprinkle on powdered sugar but it really doesn’t need anything else.
A Brief Nutmeg Timeline
Sixth Century A.D. Arab spice traders bring mace and nutmeg to Constantinople. These early spice traders shrouded their spices in misinformation and spice lore, charging high prices as a result. By the end of the 12th century, most wealthy and elite Europeans had tried these exotic spices and fell madly in love with them.
1512 Portuguese explorers ‘discover’ the source of nutmeg and establish themselves on and around the Banda islands, stocking up on mace, nutmeg, and cloves. This breakthrough makes mace and nutmeg more available and affordable in Europe.
Early 1600’s The Dutch East India Trading Company seizes control over all the Banda islands except the island Rhun, which was claimed by the English. The Dutch ferociously controlled the overwhelming majority of the nutmeg trade, destroying any plantations outside the Bandas and enforcing their monopoly by death penalty.
1667 The Dutch East India Trading Company officially trades the island of Manhattan (a fur trapping colony at the time) to the English for the Bandanese island of Rhun, solidifying their monopoly on nutmeg and mace.
1770 French spice traders successfully smuggle nutmeg trees to the island colony of Mauritius, inciting the downfall of the Dutch nutmeg monopoly. This is done by none other than Pierre Poivre (anglicized as Peter Pepper), a famous French botanist who introduced many spice plants to other French colonies.
1843 Nutmeg is introduced to Grenada by English merchants, eventually becoming the most successful producer of nutmeg and mace in the West Indies. As of 2019 Grenada is the world’s second largest nutmeg producer after Indonesia. Grenada’s flag even depicts a nutmeg fruit.
For the most updated allergen and nutritional information, it is important that you read the ingredient statement printed on the packaging at the time of your purchase.
We are aware of allergies and sensitivities. We will always declare the following ingredients on our label in the ingredients statement - they will never be hidden under the notations of "spices" or "natural flavors":
- Tree Nuts (almonds, brazil nuts, cashews, hazelnut (filbert), macadamia nut, walnut)
- Gluten containing grains - including barley, rye, oats, spelt, triticale, and kamut
- Milk & Milk Products
- Monosodium Glutamate (or MSG)
- Yellow Dye #5 (Tartrazine)
- Sulfites over 10 ppm
If no ingredient statement appears on the product label, then the products is as it appears in the product name (e.g. black pepper). This labeling policy is compliant with US or Canadian food labeling laws, as appropriate. All our retail Extracts and Food Colors are formulated without gluten.
If any product has a Gluten Free claim, the product and the manufacturing line has been validated Gluten Free.
Our facilities have allergen, sanitation, and hygiene programs in place. Our employees follow good manufacturing practices and are trained in the importance of correct labeling and the necessity of performing thorough equipment clean-up and change over procedures to minimize cross-contact of ingredients.
Again, we encourage you to read the ingredients statement on your package at the time of purchase to ensure accurate, up to date information.
This 2-Ingredient Ayurvedic Drink Will Give You the Best Sleep of Your Life
Ah, the rush of the holidays is finally over. Now it’s time to curl up by the fire with a nice book at the close of the day and catch up on some much needed relaxation. And what better way to do so than with a good night’s rest? Restful sleep can be hard to come by, but luckily, Ayurveda — the Indian sister science of Yoga — proposes a simple (and delicious) solution.
In Ayurveda — which translates to “the science of life” — food is our medicine. There are so many foods out there that combine to make the perfect sleep-promoting elixirs, and the most effective one is simpler to use than you’d think. This Ayurvedic nightcap beverage is so relaxing and easy to make, you’ll have to try it to believe it. Of all the Ayurvedic spices that are known to have sedating qualities for the body and mind, one of the most recommended for sleep is something you probably already have in your kitchen cabinet: nutmeg.
According to Ayurveda, nutmeg is used particularly in the autumn and winter months, as it is a heating spice with sedative benefits that helps balance the airy, cool, depressive qualities of this time of year. Nutmeg contains compounds that bring balance and calm to the central nervous system. These compounds not only help us feel less stressed, they also strengthen the digestive fire — called agni in Ayurveda — leading our bodies to better absorb nutrients from our food.
This sleep tonic only requires one other ingredient: cow’s milk. According to Ayurveda, warm milk is one of the ultimate nourishing foods for us in the winter, promoting healthy tissues, a balanced nervous system, and overall health in the body and mind. Heating the milk is key, as boiling it helps to simplify the molecular structure of the milk, making it more easily digestible. For best results, try organic, non-homogenized milk. To make this simple Ayurvedic sleep elixir, follow the recipe below.

domain: food


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Beijing hosted the 2022 Winter Olympics, and translation played an incredibly important role in the city’s preparations. On March 27, 2018, the city’s government launched the “2018 Online Correction of Erroneous Public Sign Translations,” a kind of call to action to citizens of the world to help improve the accuracy of public signs that are translated into English.
It is an interesting initiative if you think about it – how many times have you been travelling only to notice that easy, simple translations are misspelt or translated completely incorrectly?
Well, the city of Beijing has figured out that it is worth it to invest in getting signs right the first time around. While some of the erroneous translations are admittedly hilarious, it doesn’t go well with a government when they can’t get the most basic English translations correct.
So how does the system work? Participants can submit photos of signs they notice with poorly written English to the official WeChat account, beijingqianlong. Then, prizes will be given to the best, most efficiently provided translations.
Funny Sign Translations
English is increasingly important in Beijing. And as the Chinese like doing things right, the effort to clean up some of the hilarious English signage is a great one. Some funny examples of signage that was not translated correctly are:
- “No Watching When Walking”
- “Racist Park”
- “Don’t Bother”
- “To Take Notice of Safe the Slippery Are Very Crafty”
- “Shoplifters Will be Prostituted”
The list really is endless.
China spends billions of dollars annually on English language learning, yet continuously ranks at the bottom of the list of countries with enhanced English proficiency, both internationally and in Asia.
While decades ago, the booming Chinese population may have been a cause for worry about the world’s next lingua franca, English has held strong as the international language of commerce and remains a crucial component for economic growth.
Initiatives like Beijing’s sign-changing context show the Chinese government’s awareness regarding the importance of English for its population. In China, the English language is a required subject in schools throughout the country.
Measures like the sign initiative are just some of the ways that China is engaging its population and helping mobilize their interest in improving language skills overall, while at the same time serving as a more hospitable environment for foreign visitors.


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FBI agents seized bomb-making materials, seven guns and ammunition from the Montana home of a man they suspect of carrying out bank robberies in five states, according to an inventory list filed with a federal court.
The property seized from Richard Gathercole's home in Roundup shows that agents also found sheriff's badges and patches, a sheriff's vest, an ammunition vest, a military style helmet, an organic chemistry book and material to make identification badges.
Authorities believe Gathercole, 39, is the man they call "the AK-47 bandit" who held up at least six banks since 2012 in California, Washington, Idaho, Nebraska and Iowa. The suspect typically wore a mask with only his nose and eyes showing and carried an AK-47 rifle with a drum magazine.
Gathercole is being held in Lexington, Nebraska, where he is accused of stealing a truck and guns and firing on a Kansas state trooper who was trying to pull him over for a traffic stop last month.
The inventory list filed with U.S. District Court in Billings on June 27 listed 39 seized items, including computers, books and other documents. It does not include details of the improvised-explosive device material that was found other than "IED components."
Travis Burrows, the FBI's senior supervisory resident agent in Billings, said a total of seven explosives were found in Gathercole's home, and a bomb squad detonated them all.
The search warrant filed with the court said one explosive device was used in a 2015 bank robbery in Iowa and contained powder, metal pieces and a fuse.
U.S. & World
News from around the country and around the globe
Gathercole is scheduled to appear in court in Nebraska on Thursday on both a fugitive from justice charge related to the attempted shooting of the Kansas trooper and on the theft charges.
His public defender, Corey Burns, said Wednesday that the preliminary hearing will only determine whether there is probable cause to file those charges, and that Gathercole will not enter a plea.
He declined to discuss Gathercole any further without his client's permission, other than to say, "He is doing well."
Federal charges related to the bank robberies have not been filed. Last week, San Bernardino County, California, prosecutors said they planned to charge Gathercole with attempted murder of a peace officer for the shooting of a Chino police officer during a 2012 bank robbery.


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Curating Art and Personal Collections in Home Decor: Infusing Your Space with Personality
Decorating your home is not just about choosing the right furniture and color scheme. It is also about infusing your space with personality and creating a unique atmosphere. One way to achieve this is by curating art and personal collections that reflect your interests, experiences, and style. In this article, we will explore how to curate art and personal collections in home decor to create a space that is truly your own.
Step 1: Define Your Style
The first step in curating art and personal collections in home decor is to define your style. Your style should reflect your personality, interests, and experiences. Are you drawn to modern or traditional art? Do you prefer bright colors or neutral tones? Once you have defined your style, you can start looking for art and personal collections that fit your taste.
Step 2: Choose Your Art
The art you choose for your home should be a reflection of your style. You can choose art that matches your color scheme, or you can choose art that stands out and creates contrast. Consider the size of the art and where you will place it in your home. A large piece of art can be a focal point in a room, while a small piece can be a subtle accent. Don’t be afraid to mix and match different types of art, such as paintings, sculptures, and photographs.
Step 3: Create Personal Collections
Personal collections are a great way to infuse your space with personality. You can collect anything that interests you, whether it’s vintage cameras, antique books, or vinyl records. The key is to display your collections in a way that is visually appealing and reflects your style. You can display your collections on shelves, in glass cases, or on a gallery wall.
Step 4: Mix and Match
The key to creating a unique and personal space is to mix and match different elements. You can mix modern and traditional art, or you can mix vintage and contemporary furniture. Don’t be afraid to experiment and try different combinations until you find a look that feels right for you.
Step 5: Display Your Art and Collections
Once you have chosen your art and personal collections, it’s time to display them in your home. You can display your art on walls, shelves, or even on the floor. Make sure to use proper lighting to highlight your pieces and create a warm and inviting atmosphere. Your personal collections can be displayed on shelves, in glass cases, or on a table.
Curating art and personal collections in home decor is a great way to infuse your space with personality and create a unique atmosphere. By defining your style, choosing your art and personal collections, mixing and matching different elements, and displaying your pieces, you can create a space that is truly your own.

domain: design


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The stranger by albert camus shows a man fighting society in his head and how he deals with it the novella uses tone, theme, and literary devices to show this man's life and his sceptical view of the world as he discovers that he can change , only to find out that it is too late. To a stranger passing stranger you do not know how longingly i look upon you, you must be he i was seeking, or she i was seeking, (it comes to me, as of a dream,) i have somewhere surely lived a life of joy with you, all is recall'd as we flit by each other, fluid, affectionate, chaste, matured, you grew up with me, were a boy with me, or a. The stranger pdf - download for free so, you are anxiously searching for a working free the stranger book in pdf format in that case you certainly have to try reading it from this page. Chapter ii takes those same eleven months and reveals what meursault did when he was not being interrogated several years following the publication of the stranger obviously, camus was very much intrigued with the irony of a mother and a daughter murdering a rich stranger, who.
Essay on literary devices used in albert camus' the plague albert camus' devices and literary intelligence make it very clear that the melancholy of the town was to the extent that all souls' day was neglected the stranger, by albert camus. Short stories, irish literature, classics, modern fiction and contemporary literary fiction, the japanese novel and post colonial asian fiction, yiddish literature the stranger by katherine mansfield (1888 to 1923, new zealand. Literary devices: syntax: syntax is a key literary element throughout the progression of the novella diction: diction almost parallels syntax in the stranger throughout part i, the diction used is considerably simple. To a stranger by walt whitman made by: charlotte ruelo to a stranger by walt whitman to a stranger analysis walt whitman: born in may 31, 1819 in west hills, new york literary device: symbolism - the stranger as a possible friend, or relation. I cheated and watched stranger than fiction instead but it was worth it not only is it a great story, but it's a masterpiece in dialogue, characterization, and humor i'm glad you liked the techniques because i found them very helpful like i said.
The stranger - billy joel only the good die young - billy joel , assonance, foreshadowing, hyperbole, imagery, literary devices, music, onomatopoeia, personification, plot chart, poetic devices, songs, symbolism, tone songs & poetic devices post #14 - help post #13. Get an answer for 'what literary devices does walt whitman use in to a strangerthe only literary devices i can possibly see is that the stranger symbolizes a possible friend and the tone is kind of hopeful because he wants to bump into the stranger again and maybe he'll have the courage next time to start talking' and find homework help for. Start studying frankenstein literary terms learn vocabulary, terms, and more with flashcards any unusual devices in sentence construction, such as repetition or inverted word order, and any unusual word or phrase yesterday the stranger said to me, 'you may easily perceive.
Analyze the literary devices that camus uses to make the bleak world of the stranger come alive 0 of 6 0%: get started themes and motifs a key theme in the stranger is the irrational, indifferent nature of the universe. It is important not to confuse apostrophe, the literary device, with the apostrophe punctuation mark to a stranger born in some distant country hundreds of years from now popular literary devices view full list of literary devices ad hominem adage allegory alliteration. Foreshadowing foreshadowing is a literary device in which hints are given by the author to suggest possible future plot developments foreshadowing can be direct or subtle foreshadowing in albert camus' the stranger is, on the face of things. Category: the stranger the outsider title: free college essays - stylistic devices in the stranger by albert camus.
Themes are the fundamental and often universal ideas explored in a literary work the irrationality of the universe though the stranger is a work of fiction, it contains a strong resonance of camus's philosophical notion of absurdity in his essays, camus asserts that individual lives and human existence in general have no rational meaning. Similes, metaphors & personification success criteria:- i can skim and scan the text to find answers to the questions i can recognise literary devices such as similes, metaphors and personification in a text. The stranger (1921) the man without a temperament (1921) at the bay katherine mansfield: a darker view, jeffrey meyers, cooper square publishers katherine mansfield on imdb literary encyclopedia biography.
Throughout my chapter-by-chapter guide through the stranger, i have espoused the view that stories are literary wholes and that we must resist the urge to reach closure on what a book is saying until we have finished it this is not to say that we cannot profitably raise worldview and moral vision. I am trying to find literary devices for the novella the strangerby albert camus, other than symbol and analogyi was wondering if you could help me identify some others thanks jenna.
What literary techniques are used in the novel hoot what literary devices are used in macbeth in act 2 scene 4 best solution what are some techniques used in the novel the stranger by albert camus answer. The stranger, seattle's only newspaper: covering seattle news, politics, music, film, and arts plus movie times, club calendars, restaurant listings, forums, blogs, and savage love. Hyperbole is the use of obvious and deliberate exaggeration literary devices literary devices, terms, and elements contact search for: popular literary devices allegory alliteration allusion ambiguity of a long-lipped stranger with a brave moustache and deep brown level eyes. Are there any literary devices that you can think of in the stranger i need to do a presentation on this book and i want to know what literary devices i should look for before i start reading the book your answers will be really helpful thank you ^. Preferably referring to l'etranger (the stranger), but apart from the first person narrative, how does camus create and develop his characters.

domain: library


Former Treasury Secretary Lawrence Summers seems to have invited himself to the Federal Reserve’s September meeting.
Summers’ latest bog post is written like he’s pulled up a chair at the Sept. 16-17 Fed policy committee gathering and is warning his colleagues against a rash rate hike.
Economists think a rate decision at the September meeting is a close call.
Summers was at one point close to joining the Fed. He was, by all accounts, President Barack Obama’s choice to replace Ben Bernanke as Fed chairman. But Obama ultimately chose to reappoint Bernanke in 2009 and then picked Janet Yellen over Summers four years later after a revolt of liberal Senate Democrats.
Neil Dutta, head of U.S. economics for Renaissance Macro Research, said Summers has been reinventing himself as the “working man’s economist” ever since Senate Democrats torpedoed his Fed nomination.
Summers does make a forceful dovish case for the Fed to stand pat, warning that, if some of the global fears surrounding China and a global slowdown ultimately prove warranted, a tip of the Fed toward tightening “risks catastrophic error.”
In contrast, Yellen seems somewhat more hawkish, having expressing a desire to hike rates at some point this year. But, to be fair, the Fed Chairwoman’s current stance on rate policy is unknown. She has not spoken publicly since China’s surprise devaluation in mid-August, which set off the current round of global financial market turmoil and threw a September rate hike into doubt.
In his blog post, Summers made five points against a September rate hike.
- Data suggest slowing in the U.S. and global economies.
- Market-based inflation expectations suggest core inflation will remain well below 2%
- Arguments for “one and done” are “specious,” with the case for hitting the brakes even once not there.
- Conventional wisdom China is in its most uncertain state since it began economic reform in 1979
- Markets have already done the work of tightening, as financial conditions as measured by Goldman Sachs or the Chicago Fed index already tighter by more than a 25 basis point tightening.


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Kate Tempest’s powerfull track Europe is lost gets powerfull video.
Intro track taken from upcoming EP
From the upcoming album Marfa Myths 002
Available January 27, 2017 via Mexican Summer


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Declan Devine's almost gave up a two goal lead on their way to a lucky 3-2 victory at Hunky Dory Park
Drogheda started the game brightest, continuing their strong recovery from the dissapointment of their performance in the Setanta Cup final. Mick Cooke had them keep a high line which kept Derry on the back foot for the majority of the first half.
Unfortunately for Drogheda, their best chances fell to Alan Byrne. The big centre half was guilty of fluffing at least two wonderful opertunites to get on the score sheet. Byrne's night was made worse after his apparant own goal gave Derry took an unlikely lead before the break. Barry McNamee might claim the goal as it was his corner that drifted almost straight in.
Derry came out picked lifted the game after the break with Drogs struggling to keep to their high pressing plan. The Ulster side eventually doubled their lead following a fatal back pass allowed Mark Griffin to play Rory Patterson through to finish neatly.
Being 2-0 kicked finally woke Drogheda up, with subsititute Declan O'Brien taking advantage of some careless Derry defending, scoring two goals inside two minutes. Their fightback put Derry instantly on the back foot but as Drogheda pushed for the win, the visitors were allowed to break with Patterson being played clear on goal to snatch the win.
The victory sees the Candystripes keep up the pressure on league leaders Sligo Rovers, who take on Dundalk on Saturday evening.