A lottery is a game of chance in which players pay money for the opportunity to win a prize. The prize is often a large sum of money. People have used lotteries for centuries to raise funds for a variety of projects and purposes. The first lotteries were private games held by kings and other rulers, but after the 17th century they became increasingly popular as a painless form of taxation. Today, most states have a state-owned or operated lottery. Private lotteries also exist in many countries.
A common method of collecting funds for a lottery is to sell tickets in a public competition to determine the winners. The winner is awarded a prize, and the rest of the participants receive a smaller reward. Usually, a large prize is offered along with a number of smaller prizes. The size of the prize varies from one lottery to another, but in most cases the total value of the prizes is predetermined before the competition begins. The organizer of the lottery usually deducts all expenses (including profits for the promoter, cost of advertising, and taxes or other revenues) from the pool before distributing the remaining funds to the winners.
The first recorded use of a lottery was by the Chinese Han dynasty, and there is evidence of the lottery in Rome during the early modern period. In the United States, a privately organized lottery helped fund Harvard, Dartmouth, Yale, and other universities in the late 18th century. During the Revolutionary War, the Continental Congress sought to establish a national lottery to raise money for the Army, but it was never implemented.
Lotteries have many benefits, but they also have some disadvantages. They are a source of revenue for governments, and they can help to raise the minimum wage. They can also provide an alternative to other types of taxes, such as income or property taxes. However, they can also create a sense of unfairness in the distribution of wealth.
The purchase of lottery tickets can be accounted for by decision models that use expected utility maximization. These models can adjust for risk-seeking behavior and may include utilities that are not directly related to lottery outcomes. These models can also account for the purchasing of a ticket to experience a thrill or to indulge in fantasies about becoming rich.
Lottery proceeds have been a valuable source of revenue for governments, particularly in the immediate post-World War II period, when states had large social safety nets and needed additional money. This arrangement allowed them to expand their services without burdening the middle and working classes with excessively high taxes. However, the current economy has eroded this advantage, and states must find new sources of revenue. In order to compete with other forms of gambling, lotteries must be perceived as a legitimate and responsible form of taxation that provides a fair return on investment. Moreover, they must be transparent to prevent misperceptions about the amount of money they will generate.


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Over the past three months, Radium Capital has been working with an array of start-up founders, ASX-listed businesses with R&D programs and trusted experts in grants, incentives and innovation. Some clear themes have emerged. So whether you’re coping day-to-day; hustling to respond to the fast-changing circumstances; or have locked in a new opportunity, learn what we’ve discovered about successful R&D during the pandemic.
Innovation in the ascendancy
Radium Capital and SmartCompany recently polled more than 350 businesses owners, managers and entrepreneurs. Almost 60% of respondents said innovation is very important, with almost 40% either spending more on R&D or starting to spend on R&D for the first time due to the pandemic.
Innovation is a term that is bandied around and has become a bit of a buzzword. So much so that many people have been left wondering what innovation is. This is important because whether your innovation meets the Australian Tax Office eligible R&D criteria could make the difference between accessing the R&D tax incentive and R&D financing or not.
At its core, innovation is an idea put into action. Importantly, it must add value by solving a challenge that meets customer needs and generates revenue for a business.
If you have those key elements of an idea, a solution to a challenge and adding value to customers and your business, then you’ve likely got some eligible R&D going on.
It may seem counterintuitive that it’s prime time for innovators when the economy has fallen into an abyss. But the countless unforeseen challenges that have emerged due to the virus and its economic impacts are creating new demands. It’s clear that innovation is more important now than ever. As we face massive disruption to most aspects of our way of life, these testing times mean big opportunities.
Power of the pivot
It’s hard not to notice the media coverage of Australian businesses that have pivoted their operations in the response to the COVID-19 crisis.
It’s a trend we’ve noticed with Radium Capital clients too. And not surprisingly, it’s particularly pronounced among healthcare and manufacturing sector businesses, which have seen upticks in demand for Radium Advances of more than 160%.
There’s no winning formula or one size fits all-when it comes to pivots. They can be big or small.
Take Radium Capital client, Sydney-based biotech Recce Pharmaceuticals. Recce has developed a new class of synthetic antibiotics that targets superbugs. Recce has pivoted towards the battle to treat and defeat coronavirus, in particular antibiotic resistant bacterial infections critically ill COVID-19 patients are suspected of contracting in hospitals.
It also recently announced the successful treatment of Influenza A in mice. A development that signals its patented antibiotic, Recce® 327, may work against viruses too. Welcome news as the world battles the deadly coronavirus.
In addition to pivots, R&D is definitely continuing for start-ups at different stages and growth phases—despite the pandemic. Some businesses, including Radium client and smart home technology leader Quantify Technology, are hitting the accelerator to capitalise on opportunities the current climate has created. COVID-19 has highlighted the infection control benefits of the smart technology Quantify offers. Before coronavirus, it was making inroads into the aged-care and assisted-living sectors, but now its voice-activated technology is increasingly seen as a must-have. There is also growing interest in its products from consumers looking to retrofit their homes and businesses.
But there’s no escaping that for many R&D start-ups, COVID-19 hasn’t served up a tidy opportunity. Instead it has delivered an existential threat. To assist, we’ve been granting eligible businesses prompt access to capital using our Radium Advances. This has stabilised their cash flow and kept them afloat when traditional capital sources dried up. Now many of these businesses either want to, or need to reframe their offerings and how they approach innovation mid-pandemic.
Rediscover your purpose
COVID-19 is likely to be with us for many months, maybe years, and businesses are having to rethink their strategy on the fly. There’s no ‘how to guide’ for what lies ahead. But here are a few things to consider that may help you chart a course through the crisis.
If you plan to pivot your research or your business, think back to the reasons you originally launched your venture and what you set out to achieve. That is your business purpose.
Explore new opportunities that align with your organisation’s core purpose and values. This will give you a better chance of success. Always play to your strengths. Mid-pandemic is not the time to explore opportunities that you can’t transfer any of your current skills to. Distilleries that switched from manufacturing spirits to manufacturing hand sanitisers are a great example. They’re making completely new products for new markets, but they’re still using existing skills and resources.
Aim to think both short-term and long-term. Don’t go hell for leather developing something that has no longevity beyond the pandemic. But if you do want to seize a timebound opportunity, make sure any operational changes you make are ones you can pivot back from once this crisis has passed.
Focus on what’s important and sustainable
Once you have an opportunity in your sights, how do you get the capital to invest in R&D and make this much-needed innovation happen?
It’s important to understand that while resources are limited at the best of times, during a crisis they’re not only limited; they become uncertain too.
Take a laser-like focus to addressing the most important short-term and long-term issues your business is facing. Then make the capital you do have work as hard as possible.
Radium Quarterly Advances are a great example of this. They make your R&D capital work harder because they trigger additional refunds. So for the same annual investment, you can either spend more on R&D or raise less capital. This type of financing is cash flow friendly too. The only security Radium Advances typically require is the R&D incentive refund itself. So with no upfront fees and nothing to pay until your full refund arrives, you’re never out of pocket.
When it comes to capital, target it so you’re positioning and securing your business strategically into the longer term.
The key takeaway from the pandemic is this. You need to be taking steps now that keep the doors open, but also ensure you make it through this crisis and are around for years to come.
Remember right now isn’t forever
Australian businesses and businesses around the world were immersed abruptly into the current economic crisis by COVID-19. While the situation seems bleak now, it’s worth remembering that the pandemic will not last forever.
The economy looks set to surface from forced hibernation in stages. And that means your business can ride the coattails of one these reopening phases.
If you’d like more insights into using innovation to boost your ROI despite the COVID-19 crisis, you can check out our SmartCompany webinar on this topic.
And of course, at Radium Capital, we’re here to provide funding for eligible companies that are continuing to innovate, or are looking for strategies to help with cash flow and capital. So please feel free to get in touch on 1800 723 486 if we can help in any way.
How Carbon R&D can help with your claim
The R&D claim process can be very difficult to understand and can add stress to your plate when you’d rather be focusing on your project. If this sounds like you, then now is the time to give Carbon R&D a call.
We do our very best to make the process as simple as possible for you, and take care of all the time-consuming paperwork and calculations. Find out more about our simplified R&D process here on our website or by calling us on 1300 454 174.
Guest blog written by Radium Capital

domain: news


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domain: artistic


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Punk Rock Lives
Join Date: Feb 2002
Location: In a cabin in the adirondacks
Bikes: Fuji touring
Mentioned: 0 Post(s)
Tagged: 0 Thread(s)
Quoted: 40 Post(s)
Originally Posted by cyclingmat
I'm heading to China in a couple of weeks to cycle from Laos to Kyrgyzstan. If anyone's done this route or parts of it before, I'd love to hear any advice you've got.
In particular: What maps did you use?
Did you take a tent or was it reasonably easy to find accommodation along the way?
Any trouble form the police?
I'm aware that it's illegal to cycle through Tibet, so I'm planning to skirt round it, although there seem to be plenty of accounts on the net from people who have cycled there. However there are other areas which I've read can be closed to independent foreign travellers, eg. the road east from Khotan / Hotan. Does anyone know where I can find up to date information about this?
Thanks in advance for your help.
Just a couple generic comments, since things in China change frequently and any advice is dated by the time the ink dries. First, I found wild camping to be readily available in rural areas around rice paddies and the extensive 'reforestation' plots that they have in the country. Nor do you need to wild camp; i was able to find cheap accomodation almost everywhere. I would be eating dinner in a small outdoor 'restaurant' (I use the term loosely) and would make sleeping sounds and noises, and often the folks had a room available for cheap.
I had mixed results with the police. Usually they just wanted to see my passport. If you deal with the national police, the Gong'An, perhaps it will be less pleasant but in general I found cyclists have good rapport in the countryside.
You may hear you need 'permission' to bring your bike into China. I had no problem ( I also had a fake document I was gonna show if they asked for one, but thats a different story.
). The problem is that customs officials often make their own rules. I crossed into China from Vietnam along the coastal route, not the main crossing most people take.
I went into 'closed areas' three times. One time they let me thru, no problem. One time they put me on a bus to the other side (which was good cause the road was washed out, anyway). The third time they stopped me dead in my tracks and made me go back. I would push the envelope a bit, if I were you.
It encourages the Chinese authorities to open regions, especially to cyclists. But follow whatever rules they give you on the ground...violation of some closed areas (such as the Sonningjia region, which is where I was turned back) involves fines in the thousands of dollars. They'll put ya in jail till ya pay!

domain: geography


Mobile steel staircase is also known as mobile stairs platform can be divided of SA type folding staircase and SB type factory ladder.The moving storage ladder used in pallet racks,cantilever racks,mezzanine supplier for Rolling Warehouse Ladders and so on.And also we know that it’s very important for use right style staircase to make sure that should be very important for us do it well.
1, Equipped with metering device and with 4wheel can move easy and freely.
2, The choice of the appropriate length of the ladder, to meet the different types of light style shelves, heavy duty shelves.
3, Active step, in any position, always maintain the level of state.
4, Step with the tanker at the contact with anti-collision cushion.
5, Compact structure: shelter state, take up a small space.
6, Bearing capacity: the maximum carrying capacity of up to 200 kg.
7, Easy to install: only need bolts can be fixed.It’s easy for us to use.
The height of ladders can be 1500mm,1800mm,2000mm or other size can be Customized.
The activities of the stairs apply to all kinds of combination mezzanine racks and also used in garment factory,led light factory and so on.
The pictures for your reference.


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|By Business Wire||
|May 21, 2014 05:45 PM EDT||
Atigeo™, a compassionate technology company, today announced that the Atigeo xPatterns big data analytics platform has been officially recognized as part of the Databricks “Certified on Spark” program.
Atigeo xPatterns is among the first few certified by Databricks, which was founded by the creators of Spark and dedicated to driving its continued adoption and evolution. This certification demonstrates that xPatterns can deliver big data analytics on nearly any Spark distribution from a wide range of vendors, including existing enterprise Spark deployments.
“At Databricks, we launched the ‘Certified on Spark’ program because we recognize that a critical component of a successful platform is a thriving application ecosystem,” said Arsalan Tavakoli-Shiraji, business development lead at Databricks. “Atigeo’s xPatterns is a terrific example of an offering that builds on Spark’s capabilities to deliver next generation functionality to users and we’re thrilled to announce their certification.”
xPatterns fully integrates with and builds on Spark, a next-generation Big Data processing engine that supports batch, interactive, and streaming workloads at scale. Enterprises are leveraging Spark’s in-memory computing capabilities and full breadth of functionality – interactive SQL queries, streaming data support, machine learning, and graph computation – to unlock the value of their data.
“The performance benefits of Spark make a huge impact for companies with petabytes of data to analyze,” said David Talby, Atigeo’s Senior VP of Engineering. “Bringing the latest technologies, such as Spark, to enterprise customers, and deploying end-to-end big data analytics within days — is a combination of benefits that only Atigeo’s xPatterns can offer.”
To demonstrate the advancements offered through these technologies, Atigeo’s Senior Director of Engineering, Claudiu Barbura, will present xPatterns at the upcoming Spark Summit 2014 in San Francisco.
Atigeo is a compassionate technology company for a wiser planet. Its big data analytics platform, xPatterns, operates either on-premises or in the cloud to lower any company’s cost barrier for extracting knowledge from all available data, even with a legacy IT infrastructure. Enterprise-grade and developer-accessible, xPatterns makes data easier to leverage in its native state, greatly reducing the effort, expense and limitations of data architecture and analysis. For more information, please visit www.atigeo.com or find us on Twitter or LinkedIn.
Databricks was founded by the creators of Apache Spark, and are using cutting-edge technology based on years of research to build next-generation software for analyzing and extracting value from Big Data. They believe Big Data is a tremendous opportunity that is still largely untapped, and are working to revolutionize what enterprises can do with it. They are venture-backed by Andreessen Horowitz. For more information, please visit www.databricks.com.
Most organizations prioritize data security only after their data has already been compromised. Proactive prevention is important, but how can you accomplish that on a small budget? Learn how the cloud, combined with a defense and in-depth approach, creates efficiencies by transferring and assigning risk. Security requires a multi-defense approach, and an in-house team may only be able to cherry pick from the essential components. In his session at 19th Cloud Expo, Vlad Friedman, CEO/Founder o...
Jul. 26, 2016 04:30 AM EDT Reads: 1,868
"We host and fully manage cloud data services, whether we store, the data, move the data, or run analytics on the data," stated Kamal Shannak, Senior Development Manager, Cloud Data Services, IBM, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jul. 26, 2016 04:15 AM EDT Reads: 1,225
CenturyLink has announced that application server solutions from GENBAND are now available as part of CenturyLink’s Networx contracts. The General Services Administration (GSA)’s Networx program includes the largest telecommunications contract vehicles ever awarded by the federal government. CenturyLink recently secured an extension through spring 2020 of its offerings available to federal government agencies via GSA’s Networx Universal and Enterprise contracts. GENBAND’s EXPERiUS™ Application...
Jul. 26, 2016 03:45 AM EDT Reads: 1,830
With the proliferation of both SQL and NoSQL databases, organizations can now target specific fit-for-purpose database tools for their different application needs regarding scalability, ease of use, ACID support, etc. Platform as a Service offerings make this even easier now, enabling developers to roll out their own database infrastructure in minutes with minimal management overhead. However, this same amount of flexibility also comes with the challenges of picking the right tool, on the right ...
Jul. 26, 2016 03:30 AM EDT Reads: 1,064
"We view the cloud not really as a specific technology but as a way of doing business and that way of doing business is transforming the way software, infrastructure and services are being delivered to business," explained Matthew Rosen, CEO and Director at Fusion, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jul. 26, 2016 02:45 AM EDT Reads: 1,536
The Internet of Things will challenge the status quo of how IT and development organizations operate. Or will it? Certainly the fog layer of IoT requires special insights about data ontology, security and transactional integrity. But the developmental challenges are the same: People, Process and Platform. In his session at @ThingsExpo, Craig Sproule, CEO of Metavine, demonstrated how to move beyond today's coding paradigm and shared the must-have mindsets for removing complexity from the develo...
Jul. 26, 2016 02:00 AM EDT Reads: 1,327
DevOps at Cloud Expo – being held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA – announces that its Call for Papers is open. Born out of proven success in agile development, cloud computing, and process automation, DevOps is a macro trend you cannot afford to miss. From showcase success stories from early adopters and web-scale businesses, DevOps is expanding to organizations of all sizes, including the world's largest enterprises – and delivering real results. Am...
Jul. 26, 2016 01:45 AM EDT Reads: 2,192
SYS-CON Events announced today that MangoApps will exhibit at the 19th International Cloud Expo, which will take place on November 1–3, 2016, at the Santa Clara Convention Center in Santa Clara, CA. MangoApps provides modern company intranets and team collaboration software, allowing workers to stay connected and productive from anywhere in the world and from any device.
Jul. 26, 2016 01:45 AM EDT Reads: 1,308
The IETF draft standard for M2M certificates is a security solution specifically designed for the demanding needs of IoT/M2M applications. In his session at @ThingsExpo, Brian Romansky, VP of Strategic Technology at TrustPoint Innovation, explained how M2M certificates can efficiently enable confidentiality, integrity, and authenticity on highly constrained devices.
Jul. 26, 2016 01:30 AM EDT Reads: 996
“We're a global managed hosting provider. Our core customer set is a U.S.-based customer that is looking to go global,” explained Adam Rogers, Managing Director at ANEXIA, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jul. 26, 2016 01:30 AM EDT Reads: 1,688
"This week we're really focusing on scalability, asset preservation and how do you back up to the cloud and in the cloud with object storage, which is really a new way of attacking dealing with your file, your blocked data, where you put it and how you access it," stated Jeff Greenwald, Senior Director of Market Development at HGST, in this SYS-CON.tv interview at 18th Cloud Expo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jul. 26, 2016 01:30 AM EDT Reads: 1,476
The 19th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Digital Transformation, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportuni...
Jul. 26, 2016 01:15 AM EDT Reads: 2,529
In today's uber-connected, consumer-centric, cloud-enabled, insights-driven, multi-device, global world, the focus of solutions has shifted from the product that is sold to the person who is buying the product or service. Enterprises have rebranded their business around the consumers of their products. The buyer is the person and the focus is not on the offering. The person is connected through multiple devices, wearables, at home, on the road, and in multiple locations, sometimes simultaneously...
Jul. 26, 2016 12:45 AM EDT Reads: 640
Keeping pace with advancements in software delivery processes and tooling is taxing even for the most proficient organizations. Point tools, platforms, open source and the increasing adoption of private and public cloud services requires strong engineering rigor – all in the face of developer demands to use the tools of choice. As Agile has settled in as a mainstream practice, now DevOps has emerged as the next wave to improve software delivery speed and output. To make DevOps work, organization...
Jul. 26, 2016 12:00 AM EDT Reads: 2,149
“delaPlex Software provides software outsourcing services. We have a hybrid model where we have onshore developers and project managers that we can place anywhere in the U.S. or in Europe,” explained Manish Sachdeva, CEO at delaPlex Software, in this SYS-CON.tv interview at @ThingsExpo, held June 7-9, 2016, at the Javits Center in New York City, NY.
Jul. 26, 2016 12:00 AM EDT Reads: 1,545


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According to new research from Washington State University Spokane, REM (rapid eye movement) sleep helps children convert experiences and new information into long-term memories. Their exploration of children’s sleep needs also found that antidepressants and stimulants are disruptive to this important stage of sleep.
Published in the journal Science Advances, Professor Marcos Frank and his team showed that in young animals sleep specifically assists with vision development. As the new world is explored around them, brain circuits change in the visual cortex to accommodate those new experiences, but REM sleep is the key to saving those changes and all new information.
“Experience is fragile,” Professor Frank explained. “These traces tend to vanish without REM sleep and the brain basically forgets what it saw.”
For young children, their brains go through critical periods of taking shape—as speech, language, social skills, motor skills, vision and other cognitive functions are developed. REM sleep also helps adjust the strength of neuronal connections in the brain to match information received from the environment, making learning much easier as the memory database grows.
Some medications could get in the way of the REM sleep’s magic abilities, specifically drugs that affect brain activity –including Ritalin for attention deficit disorder and a list of antidepressants. Professor Frank says that more research is needed to find out how common medications prescribed for children impacts the brain in the short and long term.
Making sure children are getting the proper amount of sleep can be a challenge for many parents. Nonetheless, knowing how much snooze they need is a great place to start. Open up the conversation about the importance of sleep in your home and allow your children to participate in creating a soothing sleep routine.
“There is a lot of data accumulating that says the amount of sleep a child gets impacts his/her ability to do well in school,” stressed Professor Frank. “This study helps explain why this might be — and why we should be cautious about restricting sleep in our children.
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domain: psychology


I posted before about my problem with Dell and the Nvidia GPU issue. Dell fixed and returned my laptop (motherboard etc.) a couple of days ago, and now I'd like to install a new HDD.
When Nvidia's GPU started failing a while ago, Dell released a BIOS update to "fix" the problem. All it did was run the fan nonstop and prevent the laptop from shutting down when it overheated. This was basically the root cause of my laptop's demise, a couple of months after updating to that dreadful BIOS version and immediately following a recent Nvidia driver update. I'm worried about it affecting my new HDD and repaired laptop if I clone the old HDD, hence my question:
a. Clone the old HDD to my new one, then rollback the Nvidia driver? I'm not really sure what to do about the BIOS in this case- and it's really the worst offender here. Or,
b. Install the new HDD, use Vista and drivers CDs etc., then restore files from backup? More work, but willing to do it if it's worth the effort+time.


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ELMIRA TWP. — Even though they live in Otsego County, some youngsters have little exposure to rural life. Providing them an opportunity to learn about agriculture and natural resources is what an annual visit to the Fleming Farm is all about.
Between 75 and 100 fifth-graders from St. Mary Cathedral, Vanderbilt Area and Johannesburg schools got a taste of farm life during Ag & Natural Resources Day Friday.
Volunteers manned seven stations designed to show students what’s involved in life on a 600-acre farming operation. The Flemings, whose farm is one of two designated centennial farms in the county, have been hosting the annual activities for the past 10-15 years.
Among the stations giving students a quick snapshot at agriculture and natural resources: forestry; water quality; pesticides and herbicides; soil science; small animals; agriculture machinery; and beef nutrition. Scott Cook, who raises chickens, noted even young people can have an agriculture enterprise.

domain: agronomy


My new air conditioning unit was working fine up until last weekend.
I had gone to the beach with some friends during the day, and returned to a hot, stuffy house.
I started to wonder if my boyfriend had turned the temperature up because he had come down with a cold. When I asked him about it, he said that he had noticed it getting a little warmer inside, but still could hear the fan running so did not think much of it. As the night went on, the house grew warmer and warmer. When I checked the thermostat, it read 81 degrees. It was the middle of the summer and I knew something was not right. Like I said, the fan was still running so we thought what we heard was the air conditioner. The next day, I called the local HVAC company to send someone out to take a look. What they found was that the compressor was out and the fan was still running. We ended up needing to replace the compressor that day. At first, we considered holding off but then thought about how it was only going to get hotter as the summer progressed. Reluctantly, we agreed to replace the compressor that same day. We had plans to go out for dinner, but we decided to order a pizza and enjoy our new air conditioning that evening. It ended up being a good choice, because the following week was one of the hottest weeks of the year. We were happy to have out AC up and functioning correctly.


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For the first time, messenger RNA technology — the advance that undergirds the most commonly used coronavirus vaccines — has been shown effective against a deadly form of skin cancer, when used in conjunction with a second cancer drug, according to preliminary study results released Tuesday.
After surgery and as long as a year on the pair of drugs, melanoma patients in the trial saw a 44 percent reduced risk of recurrence or death compared with patients who received Keytruda alone, according to the announcement. The companies did not release the results of the study itself, which have not yet been independently reviewed.
“Today’s results are highly encouraging for the field of cancer treatment,” Stéphane Bancel, Moderna’s chief executive, said in a news release. “mRNA has been transformative for COVID-19, and now, for the first time ever, we have demonstrated the potential for mRNA to have an impact on outcomes in a randomized clinical trial in melanoma.”
Bancel said the full data from the melanoma study will be shared with health authorities, including the Food and Drug Administration, and released at a medical conference. The Phase 2b trial involved 157 patients with Stage 3 or 4 melanoma that had spread to a lymph node and who faced a high risk of recurrence. The patients were split randomly into two groups.
Positive results in a larger Phase 3 trial are required before the FDA will consider allowing the drug combination on the market. The companies said they hope to begin that trial next year.
In addition to using the breakthrough mRNA technology, Moderna’s proposed vaccine employs a “personalized” approach designed to prompt a patient’s immune system to attack the specific mutations of his or her tumors.
Francis S. Collins, former director of the National Institutes of Health, said in an interview with Washington Post Live last week that development of vaccines for cancer using mRNA technology may be one of the great medical advances to come out of the pandemic. “Cancer vaccines have had a lot of promise, but they have been really not quite taking hold because the cycle time was just too long,” he said. “Now with mRNAs, you can do that so much more quickly.”
Jason Luke, director of the Cancer Immunotherapeutics Center at UPMC Hillman Cancer Center in Pittsburgh, agreed that the results, while from a Phase 2 study, signal “a tipping point” in cancer treatment.
The ability to assess a tumor to design a personalized medication, produce it and get it into a patient within a matter of weeks is where “genomics meets computational biology meets immunology meets my patient in my clinic,” he said.
“It really sounds like science fiction. But I really do think that’s the world we’re moving into.”
Dozens of clinical trials are testing mRNA treatment vaccines in people with various types of cancer, including pancreatic cancer and colorectal cancer in addition to melanoma — some also in combination with drugs that enhance the body’s immune response. But no mRNA cancer vaccine has yet been approved by the FDA.
Merck’s drug Keytruda is a monoclonal antibody that helps the immune system fight invading cancers by removing barriers that inhibit its efforts.
“Serious adverse events” related to the Moderna and Merck treatments occurred in 14.4 percent of patients who received the drug combination and 10 percent of those who received Keytruda alone.
In 2018, the most recent year for which data is available, 83,996 people were diagnosed with melanoma in the United States and 8,199 died of it, according to the Centers for Disease Control and Prevention. The five-year survival rates of the disease are estimated at 60.3 percent for Stage 3 and 16.2 percent for Stage 4, according to the companies.
Frances Stead Sellers contributed to this report.

domain: biology


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Join Len Goodman in this special feature length video as he celebrates his time as a judge on 'Strictly Come Dancing' by looking back at some of his favourite and most memorable Strictly Come Dancing routines. Len relives some of the best, funniest and most exciting dances as well as treating fans to a unique look behind the scenes of one of BBC One's most popular and enduring programmes.
Programme Includes: - Jake Wood and Janette Manrara's Salsa
- Abbey Clancy and Aljaž Skorjanec's American Smooth
- Caroline Flack and Pasha Kovalev's Charleston
- Ann Widdecombe and Anton Du Beke's Samba
- Russell Grant and Flavia Cacace's Jive
- Any Many More!

domain: celebrity


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Synthesis and Pharmacological Evolution of Tetrahydroisoquinolines as Anti Breast Cancer Agents
Madhavi Gangapuram, Suresh Eyunni and Kinfe K Redda*
College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, FL 32307, USA
- *Corresponding Author:
- Kinfe K. Redda, Ph.D
Professor & V.P. for Research
College of Pharmacy & Pharmaceutical Sciences
Florida A & M University, 410 Foote-Hilyer Administration Center
Division of Research, Tallahassee, FL 32307, USA
E-mail: [email protected]
Received Date: March 11, 2014; Accepted Date: April 18, 2014; Published Date: April 25, 2014
Citation: Gangapuram M, Eyunni S, Redda KK (2014) Synthesis and Pharmacological Evolution of Tetrahydroisoquinolines as Anti Breast Cancer Agents. J Cancer Sci Ther 6:161-169. doi: 10.4172/1948-5956.1000266
Copyright: © 2014 Gangapuram M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Breast cancer is leading cause of mortality among women, resulting in more than half a million deaths worldwide each year. Unfortunately, the recovery rate of advanced breast cancer by current available drug treatment is till unacceptably low. Chemotherapy is the main stay of cancer treatment and most of the drugs cause general toxicity to any non-proliferating cells, which can severely limit the therapeutic values of these drugs. Tetrahydroisoqinoline derivatives (THIQs) were identified as subtype selective estrogen receptor antagonists/agonists hence, potential therapeutic agents for breast cancer. Substituted THIQs were synthesized and well characterized. Antiproliferative activity against human ER (+) MCF-7 (Breast), ER(-) MDA-MB-231 (breast) and Ishikawa (endometrial) cancer cell lines were studied after 72 hours drug exposure employing CellTiter-Glo assay at concentrations ranging from 0.01- 100,000 nM. The activities of these compounds were compared with Tamoxifen (TAM). In-vitro results indicated that most of the compounds showed better activity than TAM. The most active compounds obtained in this study were 6a, 6b, 6d and 6j (IC50=0.63, 0.23; 0.93, 0.21; 043, 0.01; 0.7, 0.02 μg/ml) against MCF-7 and Ishikawa cell lines, in comparison to Tamoxifen activity (IC50=5.14, 4.55 μg/ml). The newly synthesized molecules were docked in the active sites of the ER-α (PDB: 3ERT) and ER-β (PDB: 3ERT) crystal structures and probable binding modes of this class of molecules were determined.

domain: medical


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Circular Summer School Padova 2023
From Monday, 17th of July until Saturday, 22nd of July Tondo took part in the Circular Summer School Padova 2023, a main activity of the CLOCKS Project, co-founded by EIT Raw Materials (founded by EIT – European Union), under the patronage of the University of Padua.
The aim of the summer school was to establish innovative high-educational initiatives in the field of circular economy. In doing so, they strive to connect the PhD students with the companies and their representatives.
Their offer consisted in a series of courses, whose program can be found on their website, and a Hackathon, that has been entirely organized by Tondo Lab and focused mainly on three topics:
The first topic has been circular textiles and fashion, with the challenge presented by Albini: the textile and fashion industry is responsible for around 10% of global greenhouse gas emissions, therefore contributing to climate change. The EU has defined it as the fourth most environmentally sensitive consumption category. Nowadays, many initiatives are working on reducing this huge impact: but it’s clear that the sector needs more circular ideas to make a clear substantial change.
The second topic has been sustainable food systems, with the challenge presented by Barilla: today, modern food systems need to address many challenges, such as food management and security, sustainable agricultural techniques, food waste generation, and many more. Facing them with innovative circular solutions could lead to a substantial reduction of damage to the environment and the human ecosystem.
Finally, the third topic will be electronic waste, with the challenge presented by Umicore: annually, every person generates around 7 kg of e-waste. This means that, in recent years, we have generated about 50 million metric tons of e-waste worldwide. It’s crucial to be more and more aware of the fact that our future will be increasingly based on technology: therefore, we need to start thinking of new circular approaches for the management of e-waste.
At the end of the week, the teams presented their pitch in front of the jury composed of members of the companies who, through an evaluation form, expressed their preference considering eight evaluation areas: circularity, innovation, relevance, social and environmental impact, economic sustainability, completeness and clarity of the pitch deck, and team composition.
The winning teams, one from each challenge, later presented their brilliant ideas in front of the hackathon audience.
For the Albini challenge, the ALBINI 41 team won with a project that wanted to produce water filters from the textile for internal use and selling to other companies, thus covering the textile waste.
For the Barilla challenge, the ReSAUCE team was the winner: they proposed a sustainable Hydrothermal Extraction Plant: it will treat mix sauce bio-waste, producing biogas, char, and bio-constituents.
Finally, the team CirCo won the Umicore challenge with a social startup that aims to create a strong connection with the communities in order to offer concrete solutions to the waste of electronic devices.
Here (https://clocksproject.eu/) you can find more information about the project and here (https://clocksproject.eu/join/join-sumer-school-padova-2023/) specifically on the hackathon.


Located on the corner of Bowery and East Houston, the Bowery Wall has long served as a public exhibition space for street artists. The latest artwork showcased on this historic façade is a visual protest by none other than Banksy.
From Keith Haring to JR, the Bowery Wall has hosted an impressive roster of public works by well-known street artists throughout the years. On the evening of Thursday, March 15, a new artwork by the anonymous British artist Banksy was revealed.
The mural showcases a white background with black tally marks that double as prison cell bars—one mark for each day that the Turkish-Kurdish artist and journalist Zehra Doğan has been imprisoned for a controversial painting she created. Hyperallergic reported that her painting was temporarily projected above the New York City-based artwork last Thursday night.
In March 2017, Doğan was sentenced to two years, nine months, and 22 days in jail for painting the aftermath of a Turkish raid on Nusaybin, a primarily Kurdish city in Turkey’s Mardin province, and the site of Turkish military attacks since 2015.
In Doğan’s rendering of Nusaybin’s destruction, which was inspired by a photograph taken of the rubble, the ruined city is dotted with victorious Turkish flags. After the artwork circulated on social media, Doğan was arrested in July 2016.
According to the New York Times, Doğan still has 18 months to serve. A portrayal of her face peers out from one of the cells, a pencil filling in for one of the bars to suggest the link between freedom of speech and criminal punishment. On the bottom right-hand corner of the artwork, a label demands, “Free Zehra Doğan.”
The mural is supposedly a collaboration between Banksy and street artist Borf, who has also been jailed for his work in the past. In a statement to the New York Times, Banksy wrote, “I really feel for [Doğan]. I’ve painted things much more worthy of a custodial sentence.”
Only a few days before the mural was uncovered, a Banksy rat appeared on the clock face of a building on 14th Street and Sixth Avenue. According to Hyperallergic, the rat is believed to be Banksy’s first work in New York City since 2013.


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Please note that as of January 2009, these are no longer packed in bags but rather in a convenient table top jar display.
- Snickers Peanut Butter Squared
- Item #: 5981
CandyFavorites.com offers the internet's largest candy selection and we would love customers to share childhood memories and thoughts about sweets from their past.
As a bonus, we will choose one (1) review a week, based on creativity and originality, and award the author a $10 Sweetcertificate Gift Voucher!Read more reviews »

domain: food


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Although Sigmar Polke began incorporating appropriated photographic imagery into his paintings as early as 1963, photography played an increasingly important role in his art from the late 1960s on. Polke's earliest photographic experiments reveal an interest in the empirical world around him which he documented in a straight-forward, if imaginative fashion. Following his 1971 Paris series, Polke's photographic imagery became increasingly more ambiguous and ruptured as he began playing with the medium itself to create a complex layering of representational and abstract motifs, generating ever new levels of meaning. "Polke's use of intuition and the unconscious in his darkroom experiments roughly parallels the more refined experiments of his Dada and Surrealist predecessors. Like these artists, Polke benefited from the painter's vision and liberated the medium from the central perspective of the objective lens." (P. Schimmel in Sigmar Polke Photoworks: When Pictures Vanish, Los Angeles, 1985, p. 64)
In the early 1980's, Polke turned to the drawings of Antonin Artaud for one of his most personally revealing photographs, Artaud: Zwei kleine Zeichnungen (Artaud: Two Small Drawings). Artaud, a writer, poet and director briefly associated with the Surrealists and known for his Theatre of Creulty manifestos of the 1930s, was also an artist whose highly expressive drawings reflect his obsessions with death, sexuality, identity and the unconscious. In Artaud: Zwei kleine Zeichnungen, Polke appropriates two of Artaud's drawings, The Minotaur (fig. 1) which apppears, however obscured, on the left portion of this work, and one of his numerous self-portraits (similar to the one reproduced in fig. 2) which appears on the right.
As Paul Schimmel states, "In this work, he (Polke) practically assaults a photograph of two portrait drawings by Artaud with overlays, chemicals, penlight, and hand-colored additions. On the left is a portrait of a horned figure; on the right, the portrait of a male with viscous green fluid running out of his mouth and a hat on his head. The double portrait, perhaps a metaphor for the artist himself, provided Polke with an opportunity to address the vexing issue of the unconscious, to explore his ability to represent sexual and primitive states of being, and to confront the unknowable dark side of his own creativity, for all of which Artaud provided a historical antecedent." (ibid, p. 76)
Graphite and wax crayon on paper 24.7/8 x 18.7/8in. (63 x 48cm.)
Graphite on paper 14 x 10in. (37 x 27cm.)
Collection Florence Loeb


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The Defense Department’s internal watchdog agency plans to investigate the Air Force Academy office that supports sexual assault victims after a previous inquiry found it was derelict in its duties because of poor management.
The Colorado Springs Gazette reports the Office of Inspector General announced Wednesday it would review the Sexual Assault Prevention and Response Office.
An internal academy investigation last year said the office was plagued by infighting, rumors and shoddy record-keeping. The director resigned and the academy said it would restructure the office.
The inspector general will also look into whether the academy’s criminal investigators handle assault cases properly and will review the school’s mental health services for sexual assault victims.
The new investigation was requested by Sens. Kirsten Gillibrand, D-N.Y., Mazie Hirono, D-Hawaii, and Tom Udall, D-N.M.


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C9 Guitar Chord (C Dominant Ninth)
The C Dominant Ninth chord (C9) is made up of the Root, Major Third, Perfect Fifth, Minor Seventh, and Major Ninth
Some chord charts name this chord as:
The C9 chord is composed of the notes C, E, G, Bb, and D.
Ninth chords are a family of extended chords, created by adding the major (or minor) ninth to a seventh chord.
C 9 chord Notes:
Tones in the Dominant Ninth chord:
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What’s the story?
Cunk On Earth.
The Charlie Brooker’s Weekly Wipe spin-off – centred on the ponderings of cultural commentator Philomena Cunk – returns for a new series. Continuing in the vein of Cunk On Britain, her latest quest for truth is arguably the most ambitious yet.
Cunk On Earth will see the intrepid investigative reporter endeavour to explore “the entire story of human civilisation from prehistoric times to the present day, covering all the main bits of history, science, culture and religion.”
Will there be travel involved?
Possibly. According to the programme blurb: “Philomena asks experts hard-hitting questions about humanity’s progress and stands on or near impressive old ruins and inside museums, before the shot cuts away to some archive of the bits that don’t exist anymore or were too expensive to film at.”
That sounds utterly nonsensical.
Erm, it’s meant to be. Cunk On Earth is a mockumentary. The character is played by actor and comedian Diane Morgan, known for her roles in Motherland, Mandy and After Life.
Why didn’t you say?
I thought the part about it being a Charlie Brooker’s Weekly Wipe spin-off covered that.
When can I watch?
Cunk On Earth begins on BBC Two, Tuesday, 10pm. The full series will be available to stream on BBC iPlayer that same evening.


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Start your day right.
Set yourself up for a productive day with three simple steps.
Mindfulness - This can include 5 minutes of meditation or breath work exercises. Or take some time to journal your thoughts. Try setting an intention for your day.
Movement - Anything that gets your body moving. Such as a gentle walk, slow flow yoga or a more active movements such as a hit class or running.
Mindset - Get yourself in the right frame of mind. Make a to do list for the day of two things you would like to accomplish. Read your favorite quote. Listen to a podcast while you make breakfast and brush your teeth.


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frequent attendance, primary care, interdisciplinary teams, health care cost, social determinants, complex care, care delivery models
In this editorial, practical solutions and considerations in helping the most complex and at-risk patients in our health systems are discussed. These patients, sometimes referred to as health care “super-utilizers” in the literature, tend to be frequently seen and cared for in costly hospital and emergency department settings. Innovative care models that aim to bridge system gaps, achieve better health outcomes, and improve the well-being of both patients and providers are needed and should continue to be explored.
Sundberg G. Solutions to address frequent hospital attendance. J Patient Cent Res Rev. 2020;7:222-6. doi: 10.17294/2330-0698.1786
Clinical and Medical Social Work Commons, Community Health and Preventive Medicine Commons, Family Practice Nursing Commons, Interprofessional Education Commons, Medical Humanities Commons, Other Medicine and Health Sciences Commons, Primary Care Commons, Public Health and Community Nursing Commons
July 2nd, 2020
July 24th, 2020


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Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.
Fitz·Ger·ald(fĭts-jĕr′əld), Edward 1809-1883.
British poet and noted translator of The Rubáiyát of Omar Khayyám (1859).
Fitz·ger·ald(fĭts-jĕr′əld), Ella Jane 1917-1996.
American jazz singer known for her scat singing and for her expressive interpretation of lyrics. In the 1950s and 1960s she released an acclaimed series of records devoted to the work of important American songwriters.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
1. (Biography) Edward. 1809–83, English poet, noted particularly for his free translation of the Rubáiyát of Omar Khayyám (1859)
2. (Biography) Ella. 1918–96, US jazz singer, noted esp for her vocal range and scat singing
3. (Biography) F(rancis) Scott (Key). 1896–1940, US novelist and short-story writer, noted particularly for his portrayal of the 1920s in The Great Gatsby (1925) and Tender is the Night (1934)
4. (Biography) Garret. 1926–2011, Irish politician; leader of Fine Gael Party (1977–87); prime minister of the Republic of Ireland (1981–82; and 1982–87)
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
1. Ella, 1917–96, U.S. jazz singer.
2. F(rancis) Scott (Key), 1896–1940, U.S. novelist.
Edward, 1809–83, English poet: translator of Omar Khayyám.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
Switch to new thesaurus
|Noun||1.||Fitzgerald - English poet remembered primarily for his free translation of the poetry of Omar Khayyam (1809-1883)|
|2.||Fitzgerald - United States author whose novels characterized the Jazz Age in the United States (1896-1940)|
|3.||Fitzgerald - United States scat singer (1917-1996)|
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.


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Why I want to reach out this way
I remember feeling SO alone. I felt so embarrassed by my emotional instability, feeling like I was a sinner. I was ashamed of my unpredictable behavior and my unkind treatment of my loved ones. I felt like I was weird, like I wasn’t myself. I didn’t know who I was. I felt ashamed. I felt isolated. Do you relate to those emotions? All of us do to some extent, but those emotions are severely exaggerated when someone is dealing with mental illness.
But feeling alone was the worst part of it all. I often thought, “Am I the only person like me?”, “Am I going crazy?”, “Who do I go to for help?” I felt trapped and like I should keep all of this a secret.
Looking back, it would have made a world of difference to have someone I know, who I see as a normal and happy person deal with what I was dealing with. It would have been so reassuring, it would have healed me in a way.
I have been through a lot. I have learned a lot. I’ve suffered a lot. It’s hard to talk about some of it but other stuff isn’t. I know what I’ll being sharing would have helped me.
For now, check these out to find answers to some of your mental health questions

domain: literature


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May 17, 1994
Media Contact: Joann Rodgers
Phone: (410) 955-8659
David T. Kingsbury, Ph.D., has been named as the first associate dean for information science at The Johns Hopkins University School of Medicine, as well as first director of the newly formed division of biomedical information science and director of the William H. Welch Medical Library, serving the Johns Hopkins Schools of Medicine, Nursing and Public Health, The Johns Hopkins hospital and the Kennedy Krieger Institute.
The search committee that reached beyond the usual realm of librarians to select Kingsbury described him as possessing "the scientific, technical and administrative credentials to lead the Medical Institutions successfully into the high-performance computing of the 21st century information age."
Acting director of the library since the retirement of Nina W. Matheson, M.L.S., on January 1, Kingsbury, 53, a research biologist and geneticist, will continue as managing director of the Genome Data Base Program (GDB), a position he has held since coming to Hopkins in October 1992. He is credited with leading the revision of the GDB to make it considerably more user friendly, resulting in the number of users doubling in the first month the new interface was on line, and worked closely with Matheson to revitalize the Welch's Applied Research Laboratory.
Shortly after his appointment, Kingsbury selected Chung Sook Kim as deputy director of the Welch Medical Library. She has been acting deputy director since July. During her more than 20 years at Welch, Kim also has been assistant director for database development and access.
Professor of microbiology and immunology at George Washington University School of Medicine from 1988 to 1993, Kingsbury had been assistant director for biological, behavioral and social sciences at the National Science Foundation from 1984 to 1988, during which he served on the board of regents of the National Library of Medicine.
In his National Science Foundation role, he was its principal policymaker on all areas of biology. He also was instrumental in launching the Human Genome Initiative and in establishing computational biology as a NSF program.
Kingsbury was a central figure in the development of the govermnentwide policy on biotechnology regulation and research. He also represented the federal government's biotechnology interests to state governments and international organizations such as the European Economic Community and the Organization for Economic Cooperation and Development.
He has continued his government service as a member of the Department of Energy's Health and Environment Research Advisory Committee and its Informatics Oversight Committee, the Human Genome Coordinating Committee, and several grant review panels.
He is also the editor-in-chief of the Journal of Computational Biology. Kingsbury received a master's of science degree in microbiology from the University of Washington in Seattle in 1965 and was awarded his Ph.D. degree from the Department of Biology at the University of California, San Diego, in 1971.


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The chemical makeup of greywater varies from household to household depending on the personal habits of the members of the household and their choice in soaps and other cleaning solutions lanfax laboratories in australia has an excellent paper, domestic greywater, from their laundry products research that gives. Chemicals in the environment in these cases, the cause and effect are often relatively straightforward to determine however, the effects of living for many years on or near soils with above-average levels of contamination can be harder to determine the study of soils and human health is a complicated. Using household waste water on plants if, in a drought crisis, you no longer have fresh water to irrigate outdoor plantings, can you use dishwater effects on plants household wash water is much better for plants than no water at all, but there are possible problems if your home does not have a water softener. Household chemicals in the environment: the growth of an aquatic bacterial species on high concentrations of caffeine (2012) funded articles 1 shown that some bacterial species can metabolize caffeine, but little research has been done to study the effect of different serving size, type of product and plant variety. However, dr fraser torpy, director of the university of technology sydney plants and indoor environmental quality research group, says the air circulating inside our buildings is often more polluted than the air outside, and this can have a very real impact on our health the air circulating inside buildings.
These chemicals can enter our bodies from air and dust when we breathe and touch contaminated surfaces, accidentally transferring them to our food or more research to understand how many chemicals from household products are entering our bodies and how being exposed to all of them affects our. The objective of this experiment was to test if exposure to chemicals commonly found around the household affected the growth of plants, which could greatly affect our environment and food supply the initial idea was that they would cause negative effects because strong chemical fumes affect us. We will try to find if the improper disposal of household chemicals might have a strong negative effect on plant development we find this research interesting because we are using chemicals that are used everyday and they are disposed of without any consideration to if they might be harmful to nature our project is closely. During her research for the book, greer was shocked to learn that there's no federal regulation of chemicals in household products rebecca sutton, phd, a besides causing more serious effects like endocrine disruption, “aerosol sprays and air fresheners can be migraine and asthma triggers,” she says also consider.
Apart from any fair dealing for the purposes of research or private study, or criticism or review 2 what, and how many, household chemicals could enter the water treatment plants if the run-off, percolated water or wastewater is polluted the receiving water may be affected rapidly and obviously (eg the death of all fish in. Common household cleaning chemicals linked to asthma and reproductive harm monoethanolamine (mea) is a surfactant found in some laundry detergents, all- purpose some chemicals can be linked to certain chronic diseases, research on fish and wildlife exposed downstream of a wastewater treatment plant14.
Other toxic substances found in almost all of the dust samples include chemicals known as phthalates that are often found in vinyl flooring, food packaging, personal care products and have been linked to developmental problems in babies, hormone disruption, and are also thought to affect the reproductive. This paper aims to compile some information about heavy metals of arsenic, lead , and mercury (as, pb, and hg) sources, effects and their treatment this study is related to a research project that aims to identify potential plants in tropical country such as malaysia which can uptake heavy metal.
Regulatory oversight of toxic emissions from industrial plants and understanding about these emissions' impacts are in their infancy applying a research design based on the openings and closings of 1,600 industrial plants to rich data on housing markets and infant health, we find that: toxic air emissions. It also includes chemicals used by industries as diverse as textiles, paper and engineering there has been a tendency in the us and europe to focus on this sector rather than the basic chemicals discussed above because it is thought that , with active research and development (r & d), speciality chemicals deliver better.

domain: chemistry


Boxer: Nuke generator problems known before installation
Sen. Barbara Boxer is alleging that problems with replacement steam generators at the idled San Onofre nuclear plant were recognized by the plant operator and equipment manufacturer before installation.
Citing a proprietary report by generator manufacturer Mitsubishi Heavy Industries, the Democratic senator from California said Wednesday that some further safety modifications to the San Onofre generators were rejected by Mitsubishi and the plant operator in part because it might require a more rigorous review by federal safety regulators.
The twin-reactor plant operated by Southern California Edison has been offline for a year because of the rapid degradation of crucial tubing within steam generators replaced in 2010 and 2011. San Onofre ordinarily provides for about one-fifth of San Diego’s electricity, but was shut down after a radiation release was traced to a generator tube leak.
The full report cited by Boxer — a root cause analysis of replacement generator tube wear — was not immediately available, leaving it unclear whether Edison appropriately tailored its steam generator replacement project to regulatory procedures or may have at some point made an effort to evade safety requirements.
The nuclear commission already had the cited report but has not made it public because it contains proprietary information, said Victor Dricks, a spokesman for the agency.
Edison declined to share the report, saying it belonged to Mitsubishi.
In a statement Mitsubishi said “all design decisions for (San Onofre’s) steam generators were made in accordance with well-established and accepted industry standards and practices, along with our own and third-party operating data and experience.”
In a letter Wednesday to the chairman of the Nuclear Regulatory Commission, Boxer described the documents contained in the report, which is dated from 2012 and obtained from an undisclosed source.
“The report also indicates that SCE’s (Edison) and MHI’s (Mitsubishi) decision to reject additional safety modifications contributed to the faulty steam generators and the shutdown of reactor Units 2 and 3,” said the letter, signed by Boxer and Rep. Edward Markey, D-Mass. “We urge the NRC to immediately conduct a thorough investigation into whether (Edison and Mitsubishi) did in fact fail to make needed safety enhancements to avoid the license amendment process.”
According to Boxer, the report shows that Edison and Mitsubishi accepted some adjustments to the replacement steam generators but that further safety modifications were rejected.
Quoting the report, Boxer wrote that “among the difficulties associated with the potential changes was the possibility that making them could impede the ability to justify the (replacement steam generator) design” without requiring a license amendment.
Reading from a prepared statement, Dricks of the nuclear commission said that “we have received the letter from Sen. Boxer and Congressman Markey and we’ll respond in the normal course of business.”
Edison released a statement saying its “leadership takes very seriously all allegations raised” by Boxer and that it was fully cooperating with the nuclear commission.
A low-level petition review board of the Nuclear Regulatory Commission is already considering allegations by the environmental and nuclear safety group Friends of the Earth that Edison violated safety regulations by making substantial modifications to the San Onofre generator design without a quasi-judicial license amendment review.
Friends of the Earth said its inquiries have been hamstrung by limited access to documents labeled as proprietary, including Edison’s evaluation of whether a license amendment review was warranted. Edison is seeking broader discretion to keep some proprietary documents sealed in a separate investigation into the outage’s costs before the California Public Utilities Commission.
“We didn’t even know it existed,” Damon Moglen, energy and climate director for Friends, said of the Mitsubishi root-cause report. “There are lots of people in Southern California who are worried about this plant and they deserve to know what this document says.”
The steam generator project cost at least $670 million and already is being billed to utility customers.
Friends also is pushing for a license amendment review of Edison’s proposal to restart one reactor at partial power while it develops a long-term solution to the damaged generators.
The restart proposal is being dissected by a special team of the nuclear commission technicians and inspectors, with a recommendation expected in late-April or early May at soonest.
Boxer oversees nuclear safety issues as the chairwoman of the Senate Committee on Environment and Public Works.
Tubing within San Onofre’s steam generators functions as a barrier to radioactive water that circulates through the reactor core.


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Considering the fact that the person who is worried about dating someone with a mental illness probably has an undiagnosed illness, i’d love to see you do a follow-up on that many people don’t consider addictions, to sex, work, alcohol etc a mental illness. Skinny passions gives people who are part of the skinny community a place to find one another you are welcome to use skinny passions solely as a dating site, since it has all the major features found on mainstream dating sites (eg photo personals , groups , chat , webcam video , email, forums, etc. Eating recovery center is an international center for eating disorders recovery providing comprehensive treatment for anorexia, bulimia, binge eating disorder and other unspecified eating disorders we offer healing and hope for a lasting recovery to individuals and families suffering with an eating disorder. Eating disorder hope promotes ending eating disordered behavior, embracing life and pursuing recovery our mission is to foster appreciation of one's uniqueness and value in the world, unrelated to appearance, achievement or applause.
Dating someone with anorexia nervosa anorexia nervosa, often referred to simply as anorexia, is an eating disorder characterized by low weight, fear of gaining weight, and a strong desire to be thin, resulting in food restrictionmaintained the discipline of the guard of a gate of their cityto kill the time that must elapse before the three. Babynut my friend is dating someone whose family doesn't realize he has an eating disorder either he starves himself during the day and will eat one small mealin the evening and although skinny doesn't see himself as skinny. “eating disorders are complicated and counterintuitive,” says ilene fishman, a licensed social worker who co-founded the national eating disorders association fishman, who has private practices in new york and new jersey, has specialized in treating people with eating disorders for more than 30 years. As mentioned above, it is likely that you have already encountered someone with mental health problems in your dating life while the first people who come to mind might be those that went to the.
Read about dating with an eating disorder, written by the montecatini treatment center team read about dating with an eating disorder, written by the montecatini treatment center team i would not be experiencing the joy i was sharing with the people i dearly loved participate and en-joy it read more eating disorder articles. Starvation wreaks havoc on the body as well as the psyche, and people with anorexia suffer from a long list of physical symptoms that, at their most severe, are life-threatening. I was wondering if anyone here can shed some light on their experience dating someone with an eating disorder and the associated basket of other mental health problems that go along with it. Now that ed (insider nickname for eating disorder) and i are no longer together, i am dating real people as dysfunctional as my relationship was with ed, at least dating him felt familiar and. Many people with eating disorders suffer behind closed doors, and reading articles like 5 reasons to date a girl with an eating disorder does nothing to help them with the struggle they face every single day of their life.
Dating someone with anxiety issues or an anxiety disorder can be horribly stressful sometimes it can feel like the anxiety is a third person in the relationship, someone who wriggles in between you and your partner. If you or someone you know is struggling with an eating disorder, national eating disorder association (neda) is here to help call the toll-free, confidential helpline at 1-800-931-2237 click to. Eating disorders disproportionately affect women, so many men may find themselves in my position, but my experience and lessons learned may also apply to women dating men with eating disorders. Hi im looking for a dating site wich is made for people with eating disorders, i had a close friend who nearly died of this illness i was wondering if there were any dating sites in uk for anorexic singles. Many people with eating disorders struggle with sexual intimacy and a reduction in libido there could be many reasons for this, but two stand out there’s the emotion of body image, and how individuals who are so aware of their figures may feel about someone else seeing them.
People struggling with eating disorders need all the help they can get, so be careful with your words, stick by them, and do your research a date night at a restaurant or a birthday party. 5 reasons to date a girl with an eating disorder tuthmosis sonofra november 13, 2013 girls 3,455 comments that’s why you cannot tell if someone has an eating disorder just by looking at them (unless they are emaciated in the case with anorexia nervosa) for more information, i encourage you to do research before you make an opinion. From darkness to light a resource for child survivors of rape and sexual assaulthope for healing male rapeyes, men can be victimizedno, it does not meanthey had so recently seen the results of running counter to this savage white dating someone with anorexia man's advice in the disastrous charge ordered by wazirinatural resources self. Anorexia is an eating disorder that causes people lose more weight than is considered healthy for their age and height people with this disorder may have an intense fear of weight gain, even when they are underweight.
Dating someone with anorexia nervosa anorexia nervosa, often referred to simply as anorexia, is an eating dating someone with anorexia the dick cavett show 1968 nervosa disorder characterized by low speed dating events sydney weight, fear of gaining weight, and a strong desire. So this is my advice to anyone considering dating someone with an eating disorder: if they are honest with you and upfront about it, they’re likely trying to recover if they try to hide it, you’re in trouble. 5 real reasons to date a girl with an eating disorder rachel bourne the idea of dating someone because their illness makes it easier for you to get what you want is repulsive, if not sadistic, which is why i wanted to challenge that article and the prejudice surrounding mental health.
8 heartbreaking things you need to know about loving someone with an eating disorder by laura lifshitz 8 heartbreaking things you need to know about loving someone with an eating disorder is cataloged in anorexia, bullimia, eating disorders, love & dating, love & relationships, yourtango. Dating someone with anorexia nervosa anorexia nervosa, often referred to simply as anorexia, dating someone with anorexia nervosa is an eating disorder characterized speed dating events the dick cavett show 1968 sydney by low weight, fear of gaining weight, and a strong desire. Finding out that someone you care about has an eating disorder can throw you for a serious loop — especially if it’s someone you’re in a relationship with. Sexual anorexia is a disorder that affects someone’s appetite for sexual intimacy and it can affect both men and women those who suffer from sexual anorexia will avoid or put off any sort of sexual intimacy because of deeper issues such as a fear of intimacy, a dread of sexual contact or as a result of past sexual traumas.
Students were asked questions regarding perceived dating experiences for an individual with the disorder and their own comfort dating someone with the disorder the results indicated that although 95% of students reported knowing about anorexia nervosa, most students had little personal experience with it or with dating someone who had the.


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Spyro: Reignited Trilogy was at first set to release in just a few weeks, but was unfortunately delayed til 13th, November 2018. But if you are eager to see more of him, we got the chance to play and record three levels from the upcoming trilogy. Stone Hill, Idol Springs and Sunny Villa, each one from the three games available to play through for the first time. We could only choose one, but luckily we were three = one level each.
And I think we could agree that it felt and looked good to play, if we do not count that Chloe complained about not being able to jump in one of the fountains. Which was possible in Spyro 2: Ripto’s Rage, but it’s impossible to please everybody I guess.
It’s not hard to see that it has been put in a lot of work in these games, to fully recreate them to modern standards. It’s colourful and looks great and really do Spyro justice. It controls easily and with now support of the second analog stick, makes playing and moving the camera much easier. I chose Sunny Villa since it was from Spyro: Year of the Dragon that I played the most as a kid. And I would constantly play the skating part over and over again, so I was looking forward to doing it again in full HD.
What I have to say after playing, is that it controls and feels like before but with a major overhaul of the visual. Old fans of the series will love it hopefully and will be a perfect opportunity to let the Skylander’s generation of kids have a chance to see what Spyro is really about.

domain: hobby


Cost analysis of training out of community naval aviators for the Reserve Patrol Aviation Force
Cullen, Leo D.
Liao, Shu S.
Walsh, William J.
MetadataShow full item record
This study was conducted to determine the cost of training out of community Naval Aviators (Pilots and Naval Flight Officers) into the P-3 Reserve Force. It was designed to assess the cost of training the average Pilot or Naval Flight Officer whose original fleet experience was in an aircraft other than the P-3, and to provide to decision makers information regarding which communities contribute most efficiently to the P-3 Reserve Force. Additionally, the use of these out of community aviators was measured in order to examine manning problems at the P-3 Reserve drilling sites
RightsThis publication is a work of the U.S. Government as defined in Title 17, United States Code, Section 101. Copyright protection is not available for this work in the United States.
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USING MICROSOFT TEAMS FOR BUILDING A COMMUNITY OF PRACTICE FOR COMMUNICATIONS MARINES FOR CONTINUOUS LEARNING OPPORTUNITIES Scott, George (Monterey, CA; Naval Postgraduate School, 2021-09);This research investigates how communications Marines use a learning management system to 1) complement military occupational specialties training and 2) create a community of practice (CoP) for knowledge sharing and ...
An examination of afloat training officer milestones in support of training officer career progression Pederson, James R. (Monterey, California. Naval Postgraduate School, 2009-03);assume TO billets. As 120X officers become Manpower Personnel Training and Education and Subject Matter Experts, additional specific training may be required when fulfilling challenging billets such as the CVN TO billet. ...
Sullivan, Joseph A. (Monterey, California. Naval Postgraduate School, 1998-09-01);Helicopter terrain navigation is a unique task; training for this task presents unique challenges. Current training methods rely on dated technology and inadequately prepare pilots for real world missions. Improved training ...


Here is another report about the difficulty the police departments are facing for hiring new officers.
I think this is causing police to re-examine their recruiting and hiring procedures. What will policing look like 10-20 years from now?
Berkeley PD has many unfilled positions and has lost experienced officers to other agencies in recent years, something that rarely happened before, according to this article. The agency has a distinctive history going all the way back to August Vollmer, and was the “go to” agency in northern California for many years. Current and departed…
— Read on gcordner.wordpress.com/2018/12/22/berkeley-not-so-special-any-more/


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William Jacobsen wrote:
I am now working on getting my CO2 generator going. One of the recent
posts talked about a recipe of 2cups sugar, 1tsp baking soda and fill to =
2/3 full with water. This is what I have done. My yeast goes great =
guns for a few hours, then crashes with no activity. I've done this =
twice with the same result.
I have used that recipe for about six months now and it lasts three to six
weeks with no problems. What kind of yeast are using? Make sure it is fresh
yeast and the water you use in the bottle is lukewarm. Use only about ½
teaspoon of yeast.
My room temperature is about 74, so 70 degrees shouldn't make that much
difference. If anything, it should prolong the life of the yeast. You might
experiment with more or less baking soda. My tap water has a pH of about
7.5. If yours is a lot higher, you might even leave it out of the mix.
Kenguin at homemail_com


text:
According to the entertainment news of Thai TV3, the actress/producer Anne Thongprasom will make 2 new dramas this year.
The first drama starring James Jirayu and Bow Maylada will be produced by A-Tinnabhan, Anne Thongprasom’s boyfriend, and the director Aew Ampaiporn.
Also, Anne Thongprasom will make another new drama titled “Kaen”.
Surprisingly, Nine Naphat and Taew Natapohn are the leading stars and will have a costume fitting for their roles in late May.
Reportedly, the drama is going to start filming in June 2022.
Are you excited and waiting for these 2 new dramas by Anne Thongprasom?

domain: entertainment


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text:
The start-up of hydroelectric turbines of the Grand Ethiopian Renaissance Dam (GERD) does not aim to generate electricity, but rather to drain water stored behind the dam for construction in preparation for the third filling, according to Dr Ahmed El Mufti, an international expert in water resources, and a former member of the Sudan delegation to the GERD negotiations.
In an interview with the Sudan Today programme on Radio Dabanga, El Mufti explained that starting-up the turbine [Ethiopian Prime Minister Abiy Ahmed officially inaugurated hydroelectricity production at the GERD on Sunday] represents “the fourth unilateral step that Ethiopia is implementing without consulting Sudan”. He insists that this as a violation of international law and the Declaration of Principles signed in March 2015 by Ethiopia, Egypt, and Sudan.
In the interview, El Mufti calls on the Sudanese government “to take strong practical positions to pressure Ethiopia to stop its unilateral steps”. He describes the government’s stance as “mere talk without action”, and advises the Khartoum government to call for the intervention of the UN Security Council.
‘The third filling of the GERD is equivalent to Ethiopia having a water bomb of 18 billion cubic metres…’
“The third filling of the GERD is equivalent to Ethiopia having a water bomb of 18 billion cubic metres,” he says, and that the move threatens the El Roseires reservoir in Blue Nile state and the rest of the Sudanese dams. Sudan and Egypt’s positions on the Renaissance Dam are aligned and all of Egypt’s demands are in the interests of Sudan, and said that coordination between Sudan and Egypt in the face of Ethiopia benefits both countries.
Regarding Ethiopia granting electricity to Sudan after the construction of the dam, El Mufti said that the agreement did not specify the quantity or prices, and considered the paragraph not binding on Ethiopia.
He described Ethiopia’s handling of previous agreements as “selective”, explaining that the legal position is in the interest of Sudan, and noted that “Sudan has not obtained gains since the beginning of the GERD due to the government’s negligence and neglect”.
As previously reported by Radio Dabanga, the government of Sudan has reacted angrily after Ethiopian Prime Minister Abiy Ahmed officially inaugurated hydroelectricity production at the controversial Grand Ethiopian Renaissance Dam (GERD) on Sunday. Sudanese authorities said that the unilateral action constitutes “a fundamental breach of legal obligations” and contradicts what was agreed upon between Ethiopia, Sudan, and Egypt in the 2015 Declaration of Principles.
In a statement on Monday, Omer El Farouk Sayed Kamil, spokesperson for Sudan’s GERD Negotiations Team, says that “Sudan affirms its firm position in the dossier of GERD, which is the need to reach a legally binding agreement on the filling and operation of the dam. Sudan believes that its position is based on the reference of the international law and the Declaration of Principles signed in March 2015 by the three countries”.