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Paris’ historical heritage charms everyone. Here is a list of the most historical and picturesque hotels in Paris. All of them witnessed a period of the French History or contributes to the very distinctive luxury of our country.
1) Le Pavillon de la Reine ****
District: Temple – République
28, place des Vosges, 75003, Paris
The name of this very elegant building comes from Anne d’Autriche, queen of France in the XVIIth century, and who lived in the wing which separated the actual hotel from the Place des Vosges.
The Place des Vosges is one of the older squares of Paris, it was launched in 1612 in Le Marais district, a district filled with history.
The place didn’t change much over time: its fountains and lawns kept the same appearance.
Knowing these dates, it is impossible to doubt the historical heritage of this building: many famous personalities have slept in the hotel such as, Victor Hugo or Colette to quote only the best known.
The hotel’s rooms are sophisticated and are all unique, whilst keeping an elegant look with the use of old-looking furniture.
The suites are even more lovely, especially the “Suite de la Reine” with its made-to-measure furniture, or its wooden floor from the 17th century, the French refinement at its finest!
Many services are proposed, just like the hotel’s reputation: a 250m² spa with hammam, a jacuzzi, and a relaxation area with a fireplace and a bookcase.
iPads and iPods are even available in your room to enjoy the free Wi-Fi so you can feel at home!
The little extra? The hotel’s terrace is for customers only, in which the breakfast can be served to enjoy the wonderful surroundings that the hotel offers.
Prices: From 311€ a night (the prices are likely to change according to the seasons).
More information about Le Pavillon de la Reine – Book a room.
2) Le Meurice *****
District: Louvre – Châtelet
228, Rue De Rivoli – 75001 Paris – France
The Meurice is one of the most luxurious hotels in Paris. Indeed, its popularity is set up since 1835. By the way, it is described as the “jewel of the French luxury hotels”.
The 19th century building was visited by several artists such as Salvador Dalí.
The hotel offers 160 rooms in a very refined Louis XVI decoration style, which perfectly illustrates the French luxury. The Meurice was recently redecorated by Philippe Starck, an influential creator and decorator who brought a touch of modernity without degrading the luxury of the place.
You will be charmed by the marbled bathroom of your room, composed of a shower cubicle and a bathtub.
The Queen and King Size beds depending your room will assure you a good night of sleep!
You will enjoy the free Wi-Fi, video-game console on request. In addition, you will be offered a welcome performance to make you comfortable in your hotel.
The little extra? A luxury service for your children! Bathrobes, slippers, candies, teddy bears, and much more. Your children will no longer leave the Meurice!
The Meurice offers a spa with services for your children too! You will be able to leave them in the hands of professionals while you relax.
Two restaurants are in the hotel: the Meurice Alain Ducasse offers a high-quality gastronomic food in a splendid setting.
Prices: From 645€ a night (the prices are likely to change according to the seasons)
More information on the Meurice – Book a room
3) Hotel Regina*****
District: Louvre – Châtelet
2 place des Pyramides – 75001 Paris – France
Built in 1824 in the true spot of the former royal stables of the Louvre Palace, where kings Henry III, IV and XIII learned how to ride a horse, the Hotel Regina is a sumptuous building of Second Empire.
Despite being open for the 1900 World Fair, it has a solid reputation.
The Regina is involved in the story of cinema because it appears in 12 movies! But also in fashion because the hotel’s lounge welcomes fashion shows from famous designers each year.
Each room was recently renovated to get back the chic of the 19th century. The 99 rooms either offer a view of the courtyard or on the Tuileries garden: a relaxing and enjoyable setting.
At your disposal, you will have free luxury toiletries, free Wi-Fi, air-conditioning, and many more services worthy of a five-star hotel.
The “Parisienne” suite is the gem of the hotel. Located under the Regina’s roof, you will enjoy an uninterrupted view of Paris’ main monuments.
The hotel owns an English bar with a wide selection of tea, pastries, and whiskies which will delight the lovers of refined products.
The Regina is located in a chic district of Paris, its proximity to place Vendome and Saint-Honoré street shows an incomparable luxury. It can be the occasion of shopping in the numerous French shops which have been renewed.
Prices: From 225€ a night (the prices are likely to change according to the seasons)
More information about hotel Regina – Book a room
4) Relais hotel du Vieux Paris****
District: Saint-Germain – Luxembourg
9, rue Gît-le-Coeur – 75006 Paris – France
The Relais hotel du Vieux Paris takes you back in time!
The building was built in 1480 and belonged to Duke of Luynes and Duke of O, the latter lived in it.
During the 50s, the hotel was known as “Beat Hotel” and it is for a good reason!
Many artists which created the Beat Generation lived there such as Kerouac or Burroughs.
It is located in the Latin quarter, a historical district of Paris which is very famous, where Notre-Dame, the Sorbonne or the flower market are testimonies of the past centuries. This out-of-time place will please you for sure.
The twelve rooms of the hotel are quite sophisticated. The visible beams add an additional charm to the room.
Each room offers a flat-screen TV, air-conditioning, and a bathroom with free toiletries.
The Vieux Paris’ business corner will allow you to work in a total serenity with free Wi-Fi throughout the whole building.
The hotel offers a breakfast in your room or in a dining room.
The little extra? The “Honeymoon” special welcoming with champagne!
Prices: From 128€ a night (the prices are likely to change according to the seasons)
More information about the Relais hotel du Vieux Paris – Book a room
5) Hotel Residence Henri IV****
District: Panthéon – Saint-Michel
50, rue des Bernardins – 75005 Paris – France
Located within Saint Germain des Prés and Latin quarter, this magnificent 19th century building leaning against the old Ecole Polytechnique is likely to appeal the History lovers.
Indeed, the 8 rooms and 5 apartments of the residence Henri IV were customised and represents the King and his close relations. A total immersion in the French History!
Each room owns a kitchenette with the essentials: a refrigerator, an electric hotplate, and a microwave to cook your favourite meals in a good conviviality!
You will be able to relax in the beautiful marbled bathroom, and also enjoy the air-conditioning to stay cool during hot summer days.
To enjoy an extra relaxing moment, massages in your room are available! Relaxation assured!
The hotel is very calm and stands in front of a lovely park. It’s an asset if we are aware of its location, just close to the Boulevard Saint-Germain.
It’s important to note that the building is non-smoking only.
Prices: From 122€ a night (the prices are likely to change according to the seasons)
More information about hotel Residence Henri IV – Book a room
6) Hotel Saint Jacques***
District: Panthéon – Saint-Michel
35, rue des Ecoles – 75005 Paris – France
The hotel Saint Jacques pulls you deep into the Belle Epoque, a period of French progress during the 19th century.
Let yourself be tempted by the hotel’s sumptuous Renaissance and Impressionist paintings (from Chagall, Degas, Toulouse Lautrec…).
The old staircase, the mouldings, or even the splendid bookcase, which contains 18th and 19th century books, will carry you back in the past.
All the 36 rooms of the hotel Saint Jacques possess classic furniture, beautiful materials, or a crystal chandelier showing an incomparable refinement even if they are all different.
Each room offers air-conditioning, double glazing to avoid any inconvenience with noise, or free Wi-Fi with a computer you can borrow on request.
It is important to note that the building is non-smoking only.
The staff welcomes you 24/24 in several languages and offers a top of the range service. A babysitting service is available to your children if you want to have a getaway with your partner.
The hotel’s bar is full of charm, it offers a champagne from the cuvée Saint Jacques.
The little extra? The old-style absinthe tasting.
Enjoy a plentiful breakfast at the buffet in a dining room which owns a piano for a perfect French cabaret atmosphere!
Prices: From 103€ a night (the prices are likely to change according to the seasons)
More information about hotel Saint Jacques – Book a room
7) Hôtel Louison ***
District: Saint-Germain – Luxembourg
105, rue de Vaugirard – 75006 Paris – France
It’s within the future Hotel Louison, an old royal house that Louis XIV’s illegitimate children with Madame de Montespan were raised by Madame de Maintenon during the 17th century.
The history still fills the walls of the building in the 20th century: in 1912, the first aviators of Issy-les-Moulineaux settled in the hotel.
Each of the 42 rooms are unique, decorated differently, they offer air-conditioning, free Wi-Fi, and a TV.
The Louison also propose an apartment, the “Atelier 103” for a family trip in total peacefulness.
The typical French decoration (wooden floor, woodworks…) gives a combination between tradition and modernity. The statues stand alongside contemporary designer furniture in a perfect harmony to keep the historical atmosphere of the place without falling into extremes.
The breakfast is served in a sophisticated room with an old plan of Paris from the 18th century. The buffet offers a typical French meal: pastries and bread from a traditional bakery, macaroons, cooked meats, French cheese, and fresh fruits… something to delight the food lovers!
Prices: From 82€ a night (prices are likely to change according to the seasons)
More information about Hotel Louison – Book a room
I aim to share my tips and recommendations for the beautiful country of France. My goal is to help you plan your next adventure, whether it’s a weekend getaway or a once-in-a-lifetime trip. From finding the best hotels and restaurants, to discovering unique activities and sights, I’ve got you covered!


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The Supreme Court Act 1970 (NSW) has recently been amended in ways which, in effect, empower the Court to compel proceedings to be mediated or neutrally evaluated.
"NSW Supreme Court makes mediation mandatory,"
ADR Bulletin: Vol. 3
, Article 3.
Available at: https://epublications.bond.edu.au/adr/vol3/iss3/3

domain: law


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Tuesday, April 23, 2013
Monkey Mascot Mostly Made
It may not look like it yet, but this weird flat looking thing will soon be a monkey!
I have spent all of Knitting and Crochet Blog Week so far working on my monkey mascot. I haven't had a chance to stuff him yet, but once I do, he will accompany me through the rest of my Knitting and Crochet Blog Week. Tomorrow me and my monkey will work on our infograph. I think I will try to do one about yarnbombing.
I decided to make the monkey mascot in the colors that Eskimimi has in the pictures of the different houses. I saw them as Blue(ish), white and yellow. So I tried to incorporate that into the theme of making my mascot.
Once Knitting and Crochet Blog Week is over, I will yarn bomb my mascot friend somewhere where he will be enjoyed by people. Perhaps that can be my extra credit assignment.
I hope you all enjoy my attempt at a monkey mascot.

domain: design


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By Numbers We Prevail
Riders of Western Australia or ROWA are a group of people who enjoy everything on 2 wheels. We are not a club, association or organization.
Organization makes the world go round. As long as the world goes round, we don't die.Lets not die.
Free forum : This is the forum to the Star Seed Union United's public notifications, actions, and debates. All are welcome with open arms into our organization who wish to enter

domain: hobby


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Researchers from the University of Eastern Finland and the University of Helsinki studied the intentions of consumers to consume insecticidal foods among vegetarians, non-vegetarians and plants that eat plants. They examined the attitudes, the subjective rules, the control of the perceived behavior and the fear of the consumption of insecticidal foods, as well as the conditions for the ingestion of food based on insects among these food groups. 567 people participated in the survey by completing an online survey. Of the respondents, 73% were surveyed, 22% were non-vegetarians and 5% were vegetable plants.
Vegans maintained a stricter attitude about eating out of insect foods, and their standard of self-eating insects was weaker compared to those of non-vegetarian plants and vegetarians. The control of Vijan’s perceived behavior of eating insects was vexgen keto stronger than pure animals and non-vegetarian vegetarians. In addition, vegetarians were much more determined than others to eat non-nutritious foods, even if they were nutritious, safe, affordable and convenient. The weak intention of the vegans, the negative attitude and the low desire to eat insects in the future show their different nutritional identities compared to those of non-vegetarians and vegetarians.
Non-vegetarian vegetarians, on the other hand, were the most positive attitudes towards the consumption of insects. Both vegetarians and non-vegetarians and mushrooms believed that the consumption of insects was sensible and provided a solution to the problems of nutrition in the world. On the contrary, vegetarians believe that the consumption of insects is irresponsible and morally incorrect.
“We expected there to be differences between these three groups, and we expected vegetarians to have the most negative attitudes about eating insects,” he said. “Green sees insects as living organisms, like any other animal.” University of Eastern Finland: “The responses of vegetarian botanists that eating insects in the West do not solve the problem of food shortages in the world, especially when the waste of food is wasted all the time.”

domain: sociology


- Police have gunned down two dangerous thugs suspected to belong to the Gaza gang in Njiru, Nairobi
- The gang had attempted to rob a business but were spotted by residents who raised an alarm
- Police recovered a pistol, several mobile phones and crude weapons from the suspects
Police in Njiru, Nairobi have killed two thugs suspected to be members of the deadly Gaza gang from Kayole.
The gang members had raided Njiru market on Saturday, May 27, where they attempted to rob a business.
TUKO.co.ke has learnt that members of the public had spotted the gang and raised an alarm forcing them flee the scene.
According to sources, flying squad officers, chased the gang members fatally shooting two of them.
Police recovered a pistol, crude weapons and several mobile phones from the suspects.
Residents of Njiru said the Gaza gang has lately been targeting the area after most of the group members had been killed in Kayole and Soweto.
Njiru and other parts of Nairobi's Eastlands area have suffered from increased crime blamed on organised crime syndicates and groups.
The two most notorious gangs in the city are Gaza and Eastleigh's Super Power gang that have claimed lives of civilians and police officers.
Have something to add to this article? Send to firstname.lastname@example.org
Watch what Kenyans think of Muthama's role in NASA:


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Please use this contact form for a special requests and special demands.
Just pick proper category from SUBJECT menu.
Olivera GolfArt Gallery&Shop
Olivera GolfArt Gallery&Shop is unique place, where you can find premium quality - limited edition Golf Art prints, created by Olivera - worldwide renowned Golf Artist. Like a unique gift for avid golfers, or just for your home or office, for Golf Club or Hotel, Olivera GolfArt is the perfect choice.


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9ct Yellow Gold Gypsy Set Diamond Heart Pendant
Heart symbols are represented in jewellery collections worldwide and are a beautiful way to add sentiment and show love for someone close to you. This heart pendant features a stunning gypsy set diamond (0.01ct total) and has a vintage yet modern feel. Pair with the matching hoop earrings for a complete style or stack with our other gold pendants for a unique style!
9ct Yellow Gold


cabo dress Long-sleeve midi dress with slit
- Smocked back for a better fit
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- Care: Machine wash
Please see our shipping information for delivery timelines.
All bodysuits, swimwear, hosiery, jewelry and all intimates except bralettes are final sale.
Sale items marked at 50% off or greater are final sale.


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Inspired by this Quora thread.
HINT: it's really all about my editor.
Men of NYC: just do exactly this. Artist Nathan Pyle has created the perfect GIF guide to being a gentleman on a date.
Nathan Pyle's NYC Basic Tips and Etiquette gives you the only guide you'll need to verbose menus and mysteriously unmarked condiments.

domain: artistic


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What exactly does that mean?
Really, is there an objective truth? Where does that exist? In the mind of what? All that we as humans perceive comes through our eyes, our lens, our brains, our perspectives, and our experiences. We do not perceive an objective separate reality; all that we perceive comes in through the filter of our minds. If there is an objective truth, it is not something that we have access to, and thus becomes irrelevant to this conversation.
Given our subjectivity, what does it mean to tell the truth? Have you ever beheld a situation in which two, or three, or multiple possible truths presented themselves and you had no idea upon which truth or understanding of the situation to act? When I have found myself in this situation I have found that the best I can do is to humbly accept the limits of my knowledge and experience and to act on whatever feeling is strongest…without the conviction that a claim to ultimate truth might lend to my words. Without believing that I have a corner on the truth it’s a lot easier to admit when I’m wrong or have misspoken.
The question in my mind is whether the point is really to tell the truth or to act in integrity? If truth has an unquestionable status in our culture that confers upon the bearer of the “truth” a certain amount of power, do we use truth to seek power? And are we ready to bear that power responsibly, or do we wield the truth seeking power that comes with being unquestioned? This seems to me to be another refuge for our desire for certainty, respect, and status. Yet the question remains, which version of the truth will you present? For what reason, what is the motive of presenting words or ideas in a certain way?
It’s so easy to say just tell the truth, but even a yes or no question has meanings imbued that while unspoken are just as relevant to how the statement is given or perceived…
All this is to say, truth can be a cop-out, a word used to justify saying something unsavory that is really simply a perception, and an ugly one at that. We can use the excuse of truth to communicate something to someone that is judgmental, hurtful, and unkind, something that when we view from a different perspective actually looks quite different…but the damage is done, we already spoke the “truth.”
This is not a polemic against honesty but a distinction between a dogmatic pursuit of an unrealizable ideal and an authentic owning up to our own unsavory motivations as well as the limits of our own perceptions. If honesty is really what’s at stake I think it would serve us all to ask ourselves what we stand to gain or what it feels like to say what we think we need to say. If there is a desire to be right, to make someone see something about themselves, or to clear our own space of something we don’t want to carry anymore, we may want to ask again if it is such an altruistic thing to “tell the truth,” and what may be hiding beneath those purely held words and ideals…

domain: psychology


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ShoutSouth! New creative writing festival for children
As Nick Hornby opens the doors of his new Ministry of Stories to young would-be writers, the organisers of London’s newest creative writing festival for children, ShoutSouth!, are taking a well earned break.
ShoutSouth! took place at London South Bank University during November 2010. It was organised by a group of children’s authors, Children’s Writers and Illustrators in South London (CWISL). Working with schools in three different south London boroughs - Lambeth, Southwark and Wandsworth - and in association with those boroughs’ local library services, CWISL devised and delivered three days of intensive workshops in creative writing. Participants, who were aged between 10 and 13, were given instruction on all stages of the story-making process: from plotting and story arcs to creating setting and characters, and editing their work.
20 CWISL authors took part, running over 75 different workshops for more than 230 children over three days.
Writers as role models; writing as a career
The project aimed to provide a positive experience of stories and books for children who may not have a culture of reading at home. It also set out to present careers in writing and illustration as an attainable goal.
Author Beverley Birch, CWISL chair, explains, “We had three main aims for ShoutSouth!: we wanted to give the children a love of story; we wanted to teach them the tricks of the trade that would enable them to create their own stories and illustrations; plus we wanted them to see authors as role models and consider writing or illustration as a career.”
Dialogue between communities
ShoutSouth! was also set up to promote dialogue between children from different communities: the children, who were from Years 5, 6, 7 and 8, worked in small groups and these were carefully mixed to blur boundaries based on postcode, year group, gender and ethnic group.
Schools were asked to select children with a broad spectrum of abilities. Organiser and CWISL member Margaret Bateson-Hill says, “We asked schools to select children on the basis of enthusiasm and motivation as well as creativity and talent.”
Teacher Dominique Romon from Charles Edwarde Brooks College was full of praise for the project. ”The children learned lots about the techniques of writing,” she said. “But more importantly, they’ve been inspired to try them out. On the first day they were quite reluctant to start writing; on the final day, they were all talking about their ideas, and so eager to put them down on paper.”
She was also impressed at the way the project brought children from different schools together: “They worked together really well in their workshop groups, and I know that lots of our pupils have made new friends. They were swapping email addresses with children they met at the event and many have kept in touch.”
LSBU Aim Higher programme
London South Bank University hosted the event, and LSBU students acted as mentors helping in the sessions. This support was provided through the Aim Higher programme and as part of LSBU’s widening participation programme.
Mark Ellis, Schools and Colleges Outreach Manager, explained why the university was so pleased to host the event. “We understand the importance of working with children at a very young age if we are going to influence their aspirations. With research showing that the best way to pass on information about further education is by providing young people with experience of what being a student actually involves, we arranged for LSBU students to work with the children in each of the authors' sessions, acting as ambassadors for further education.”
He added, “We offer courses in English with Creative Writing, and it would be fantastic to see some of the young people who took part in ShoutSouth! return to LSBU as students.”
Anne Bryant, EMA Coordinator at Loughborough Primary School, records the effect ShoutSouth! had on her students: “It was a very different experience for both pupils and staff and has inspired us to organise events with a writing focus within our school – and maybe even inspired the teachers to develop or extend their own story writing skills!”
She adds, “Attendance at the Saturday workshop was voluntary, and it was gratifying to discover a turn-out of 24 out of 26 pupils arriving at school on the Saturday morning to be duly shepherded to LSBU on the bus! This is real proof of how much the children enjoyed the experience."
“All the children who took part worked immensely hard: the quality of the stories and artwork they produced is very high indeed,” says Beverley Birch. “We’re delighted to say that the children’s finished work will now be published in a colour ShoutSouth! magazine. 6,000 copies will be printed and distributed through schools and libraries in south London and beyond in January.”
Participating schools were: Bacon College, Charles Edward Brooke CofE Upper School, Chesterton Elliott, Granard, Loughborough Primary School, Walnut Tree and Walworth Academy.
The ShoutSouth! magazine is funded by supporters including the Miles Trust for the Putney and Roehampton Community, Ryman, Hachette Children’s Books and Egmont UK.
For more information or to request a copy of the ShoutSouth! magazine visit www.shoutsouth.org.uk


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Shi'a Islam in Indonesia represents a small minority in that largely-Sunni Muslim country. Around one million Indonesians are Shias, who are concentrated around Jakarta. Indonesian Shia are found in areas of Java, Madura and Sumatra.
Banda Aceh in Acheh, in the north of Sumatra, was the original centre for Shias in Indonesia; it was from there the Shia faith spread across Indonesia.
Among the Indonesian communities which practise Shiism are minority segments of the Hadrami, Arab-descended Indonesians, who have a "small, but increasing, minority of Shia followers." Another group are the Shia of Pariaman and Bengkulu in Sumatra, and Sigli in Aceh, who claim descent from Indian sepoys, and are known as orang sipahi or orang Kling. The orang sipahi traditionally practise the Shia tabut ritual, though in Aceh it has been banned since 1953.
The 2010 report to the United States Congress by the United States Commission on International Religious Freedom noted attacks against the Shia communities in Indonesia, particularly in East Java and Madura in 2008. In one incident in Madura, local villagers surrounded Shia houses and demanded they desist religious activities, but the crowd was dispersed by local leaders and clergy.

domain: geography


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Title: Rompecorazones Remixed
Label: Defected Records
Remixers: Carl Craig, Livio & Roby, Reboot, Yoruba, Nic Fanciulli, Charles Webster, Damian Schwartz
Formats: double LP, digital, 2 CD,
Release Date: February 15th 2015
A1. El Solitario (Carl Craig Remix)
A2. Desesperado’ (Livio & Roby’s dcnstrct Remix)
B1. We Love You (Reboot’s Unicorn Remake)
B2. Hurt (Yoruba Soul Mix)
C1. Desidia (Nic Fanciulli Remix)
C2. Rompe Corazones (Charles Webster’s Club Mix)
D1. La Salida (Guti Club Remix)
D2. Magia (Damian Schwartz Worship Mix)
As following of the Guti’s “Rompecorazones” album released in the last summer, Defected is proud to present “Rompecorazones Remixed”, where different skilled and well known producers put their hands on some tracks, revisitating the original themes and adding something of their own.
In the overall, all the tracks sound fine, precise and very well balanced, and between all these house, deep house and tech house shades it’s possible to catch the essence and the vibe of the tracks.
Ahead of the album’s release, check out this animated short to accompany Carl Craig’s remix of ‘El Solitario’ produced by visual artist Andreas Miro.


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Pencil Sketch Edition
Available Hand-Signed by your Favorite DUCKMAN!
Forget the fuss of frame shops. Receive your print professional framed by our expert framers and it will arrive ready to hang and enjoy at a price and quality that can’t be beat! A solid-wood frame finished in Black Satin surrounds your artwork. The design of the frame is the perfect compliment to the pencil sketch. When you see it in person you will be thrilled!
*All framed prints take approximately 14 business days to process and ship. Call for more information.
$75 – $150


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Targeted drug delivery enabled by genetically engineered nanoparticles
In a pre-clinical study, researchers were able to genetically engineer cell membrane-coated nanoparticles to deliver dexamethasone directly to the inflamed lungs of mice.
Nanoengineers have developed nanoparticles that target inflamed endothelial cells in the lungs to deliver drugs specifically to their desired site of action. As a proof of concept, the researchers filled the nanoparticles with the corticosteroid dexamethasone (which is currently being used in clinic to help combat respiratory symptoms of COVID-19) and administered them to mice with inflamed lung tissue. The in vivo study found that inflammation was completely treated in mice given the nanoparticles, at a drug concentration where standard delivery methods did not have any efficacy.
The developers of the cell membrane-coated nanoparticles, scientists in the lab of University of California (UC) San Diego nanoengineering professor Liangfang Zhang, stated that their particles are unique in that they are coated in a cell membrane that has been genetically engineered to bind to inflamed lung cells. The lab has previously used cell membrane-coated nanoparticles to absorb toxins produced by MRSA; treat sepsis; and train the immune system to fight cancer.
“In this paper, we used a genetic engineering approach to edit the surface proteins on the cells before we collected the membranes. This significantly advanced our technology by allowing us to precisely over-express certain functional proteins on the membranes or knockout some undesirable proteins,” stated Zhang, who is a senior author of the paper.
Joon Ho Park, a graduate student in Zhang’s lab and first author of the paper, explained that they recognised that inflamed endothelial cells over-express a protein called VCAM1, which attracts immune cells to the site of inflammation. In response, the immune cells express a protein called VLA4 that binds to VCAM1. He explained that to target the nanoparticles they engineered the cell membranes to constantly over-express VLA4, enabling them to target VCAM1 and thus, the site of inflammation and then release their drug payload to treat that specific area.
While the nanoparticle will not directly enhance the efficacy of the drug it carries – dexamethasone in the current study – concentrating the dose at the desired site of action may allow for lower dosages to be used, since a greater percentage of the dose accumulates at the target and has time to be effective before it is cleared from the body. In the dexamethasone study, the team found the drug accumulated at the site of interest at higher levels and faster, than with standard drug delivery approaches.
The researchers noted that this genetically engineered cell membrane approach is a platform technology that in theory can be used to target not only inflammation in other areas of the body, since VCAM1 is a universal signal of inflammation. “This is a versatile platform, not just for lung inflammation but any type of inflammation that upregulates VCAM1,” said Park. “This technology can be generalised; this engineered cell membrane-coated nanoparticle does not have to overexpress VLA4, it could be swapped out to another protein that can target other areas of the body or accomplish other goals.”
To engineer the cell membranes to overexpress the VLA4 protein, Park and the team use a recombinant viral vector. They start by packing VLA4 genes into a viral vector. This reprogrammed viral vector is then inserted into cells derived from mice and grown in vitro. The genes carried by the vector are then incorporated into the genome of the murine cells and, as a result, produce membranes that constantly overexpress VLA4.
The researchers explained that they now want to experiment with creating their nanoparticles using human cell membranes, engineered to express the human version of VLA4. They cautioned that a lot of development needs to occur before the technology could be tested in clinical trials, but that these early results from the platform technology are encouraging.
“By leveraging the established gene editing techniques, this study advances the cell membrane-coated nanoparticles to a new level and opens up new opportunities for targeted drug delivery and other medical applications,” concluded by Zhang.
The study was published in Science Advances.

domain: chemistry


text:
LINCOLN — In a federal courtroom on Tuesday, the son of illegal immigrants caught up in a raid in O’Neill a year ago explained how his parents worked to avoid detection and deportation.
Antonio Castro said his stepfather and mother listed his name — rather than theirs — as the owner of property or the signature on banking accounts.
After he turned 21, he was asked to be the registered manager for the liquor license for the family’s La Herradura restaurant in O’Neill because the parents lacked the paperwork of legal residents.
When he asked his stepfather why he paid his workers in cash, he was told it was because many of them didn’t have Social Security numbers, and thus were illegally working in the United States.
Castro, now 23, said he had growing fears that his parents would be deported as the summer of 2018 wore on and federal immigration officials began stopping cars to question immigrant workers about his parents’ operation in O’Neill. Once, he even urged his stepfather to go to Las Vegas, where the family owned a handful of homes, to lie low for a while.
“I knew if my dad got caught, he’d be in a lot of trouble and I wouldn’t see him anytime soon,” Castro said.
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The testimony came on the second day of a federal trial of three people charged in an alleged conspiracy targeted in a massive immigration raid in August 2018 on businesses in the O’Neill area. The raid focused on Castro’s stepfather, Juan Carlos Sanchez-Delgado, and his mother, Magdalena Castro Benitez, who ran a staffing service that provided workers — all illegal — for a tomato greenhouse, a potato processing facility, local hog confinement barns and other businesses in the O’Neill area.
The parents also ran a restaurant and a Hispanic grocery store where Castro said he’d withdraw up to $80,000 on paydays to pay workers lined up by the staffing company, JP and Sons.
When these workers were hired, were they asked to provide Social Security numbers or other identification? asked one of the federal prosecutors, Lesley Woods.
“No, ma’am,” Castro responded.
Castro’s stepfather, the purported ringleader of the staffing service and a Mexican national, pleaded guilty in March to conspiring to harbor aliens for financial gain, which is punishable by up to 10 years’ imprisonment and a fine of up to $250,000. Sanchez-Delgado has not yet been sentenced; he has agreed to testify against the three people who have been charged with being part of the conspiracy. Benitez took a plea deal in the case and is scheduled to testify.
The three on trial — John Good, an Atkinson car dealer and businessman; John Glidden, the manager of an Ainsworth hog confinement operation; and Mayra Jimenez, a manager at the O’Neill Ventures tomato greenhouse — have all pleaded not guilty, saying they were unaware that the employees provided were not legal workers.
They are the only ones out of more than 100 people detained in the O’Neill raid to contest the charges. Good, who was the listed owner of La Herradura and also the listed owner of Sanchez-Delgado’s home in O’Neill, has also pleaded not guilty to charges that he laundered money for Sanchez-Delgado and his family.
Earlier on Tuesday, the agent in charge of the O’Neill raid for U.S. Immigration and Customs Enforcement, Robert Visnaw, testified that local sheriff’s deputies provided the initial tips in April 2017 that led to the raid 16 months later.
Visnaw said that Sanchez-Delgado had been identified as a Mexican citizen, and not a legal U.S. resident, following a traffic stop that spring. Later, in October 2017, two of his staffing service employees came forward, he said, leading to suspicions of a broader conspiracy.
That led to attempts at surveillance of Sanchez-Delgado’s businesses — which Visnaw said proved unsuccessful in a farm town of 3,700 were everyone knew everyone — a “trash pull” of rubbish from the grocery store and eventually to wire taps.
About 5,000 phone calls were captured in less than two months, leading to the enforcement operation, in which more than 400 federal, state and local officers raided businesses in O’Neill, Atkinson, Ainsworth, Long Pine and Stromsburg, as well as in Minnesota.
The defense attorneys on Tuesday asked several times why some others, such as those who owned the hog confinements or managed the tomato plant, were not also indicted. They have claimed that their clients were arrested as “scapegoats” and to justify the massive raid.

domain: news


Meet our family
Scotty Brand potatoes come from Albert Bartlett, a family-run Scottish company based in Airdrie, North Lanarkshire.
Founding the company in 1948, Albert Bartlett himself invested £30 in an old water boiler and a cast-iron bath, in order to set up a small beetroot-boiling operation, in Coatbridge, under the Scotty Brand name.
Ronnie Bartlett is Albert’s grandson and proudly heads up the company today. Working with a number of farmers across Scotland, Albert Bartlett then grades, washes and packs Scotty Brand potatoes.
The company slogan: ‘Naturally Grown, Naturally Tasty’, underpins everything the company does – just as it always has. It strives to provide value and quality, achieve excellence in environmental care, as well as innovating and exciting consumers.
Farming for more than 60 years, Albert Bartlett is fiercely committed to natural production with minimum interference. It has achieved several industry accreditations as a result of this commitment to the environment and sustainability. The company not only agrees planting and agronomy with all its growers, but also irrigation, harvesting and storage. It monitors insect activity, to minimise the use of pesticides, and uses advanced technology to conserve water and reduce its impact on the environment.
Modern energy and building management systems enable tight control of its consumption of electricity, gas and water. In fact, 70% of the water used in the potato washing process is rainwater harvested from the roof, with the remaining 30% being provided by the company’s own borehole.


George and Janet Dillard bought a home in SaddleBrooke, a 55-and-older community in Tucson, Ariz., where they hoped to meet neighbors with common interests and enjoy the tranquility of the desert and mountain setting.
But two years ago, a trio of "pickleball" courts were opened about 100 feet from the Dillards' property. Their peaceful lives were disrupted, as was the harmony in SaddleBrooke.
The sport's wood and graphite rackets and plastic balls meant "there was a constant banging" when the courts were in use, often from morning until evening, says Mr. Dillard, a former insurance executive. "We had to take action."
Forget shrinking nest eggs or threats to Social Security. The hot topic in retirement communities today is pickleball.
A fast-growing sport, pickleball is taking so-called active-adult enclaves by storm. Part badminton, part ping-pong and part tennis, pickleball doesn't put a lot of strain on aging joints, fans say. And with courts about a quarter the size of those used in tennis, it doesn't require players to cover much ground.
It's "the most addictive sport I've ever played," says Jeff Shank, a 56-year-old retired businessman who logs about two hours a day with fellow pickleballers in The Villages, a large retirement community in central Florida. "It's like a drug."
The appeal is lost on other retirees. They think the sport's noise (many describe a "ping" or "pop") and towel-snapping ethos (players "whoop it up" and "do a little trash talking," says David McCallum, son of one of the sport's inventors) have no place in their backyards.
Tennis players, in particular, are up in arms. That's because as pickleball moves into communities with tight budgets or a dearth of vacant land, participants often make a grab for tennis courts.
In some communities, the divisions have prompted heated meetings among property owners, calls for noise studies and even claims that pickleball is destroying property values.
In SaddleBrooke, pickleball foes, citing a local noise ordinance, succeeded in stopping play on the three courts opened in 2008, after pickleball players raised about $22,000 to help defray the cost of building them. Another neighborhood in the community has since blocked plans to relocate the courts to its neck of the woods.
Jim Morris, 68, that neighborhood's representative to the homeowners' association, says, "We didn't want [pickleball] within 400 feet of the nearest home."
Pickleball itself is no spring chicken. Invented in 1965 by three men including Joel Pritchard, a congressman from Washington, the sport was named after the Pritchards' cocker spaniel, Pickles. For decades, the game was little known outside the Pacific Northwest.
Today, the sport boasts an estimated 100,000 adult players, more than triple the number in 2003, and there are about 2,500 public courts, versus just 150 that year, according to the USA Pickleball Association.
Del Webb, the country's largest builder of active-adult communities, had pickleball courts in fewer than one in five of its developments in 2006. Now, says Jacque Petroulakis, spokeswoman for parent company PulteGroup Inc., the figure is above 50%, and Del Webb incorporates pickleball into almost everything it builds.
"It's the hottest craze sweeping our communities," she says.
Hot also describes the tempers in some neighborhoods.
Last spring, the homeowners' association in Beacon Woods—a 2,700-home community in Bayonet Point, Fla.—approved a request: adding pickleball lines to one of four tennis courts. The change "does not obstruct" tennis players from using the court, says Ann Bunting, president of the association.
But that's not how tennis players see it.
"They took the court without our consent," says Ignacio Rodriguez, 68, a Beacon Woods tennis player. Some two dozen tennis players, Ms. Bunting adds, signed a petition in protest.
In Mission Royale, a 55-plus community in Casa Grande, Ariz., the local pickleball club is trying to secure courts of its own. Partly in response to noise complaints, the community's developer, Meritage Homes Corp., recently said it would be willing to spend "significant dollars" to relocate pickleball from a converted tennis court, says Jeff Grobstein, desert region president for Meritage.
Ron Heymann, 65, whose home is about 100 feet from the existing courts, says he won't be sorry to see pickleball go. The noise from games—that of a "hard plastic ball thunk-thunking repetitively on a hard wooden paddle"—is "akin to a toothache that won't go away."
Pickleball players in Mission Royale dispute such claims—for the most part. "There is a constant 'ping, ping,'" concedes John Grasso, 61, president of the local pickleball club. In March, Mr. Grasso says the club purchased a decibel meter from RadioShack. The findings: Tennis reached about 58 decibels while pickleball hit about 60. "There really was no difference. It's just a different sound."
The difference was enough to evict the sport from its home in SaddleBrooke. Residents there, in 2008, first asked pickleball players to switch to a rubber ball to cut back on noise. Pickleball players passed.
"Ask golfers to use a different kind of ball, and see what they say," says John Benter, 69, local pickleball president.
A $4,500 noise study found that sounds from pickleball play were spiking above the county's 60-decibel limit, which applies to ongoing noise. As a result, the homeowners' association banned use of standard pickleball paddles and balls on the courts, effectively shutting down play.
This spring, a proposal to relocate the community's pickleball courts near a softball field was abandoned after residents protested. "Nobody was throwing themselves in front of bulldozers—this is a retirement community," says Mr. Morris, the homeowners' association representative. "But we rallied our troops."
The SaddleBrooke developer has since offered the pickleball club yet another piece of land. But players say the two-year battle has left them wondering if they will ever get a fair shake.
Says Mr. Benter, the pickleball president, "Anyone who does not play pickleball now has anxiety about pickleball sounds."
Write to Anne Tergesen at firstname.lastname@example.org


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There are lots of ways to burn fat, and get fit. For example, you can run, walk, swim, cycle, lift weights, play sport – basically any activity that gets you moving!
There are pros and cons to each of the above methods, for example the benefits of running are that it’s a great aerobic workout, and also strengthens the legs, however the downside is that it’s high impact, and can cause knee/lower back pain.
I get lots of my clients doing different forms of cardio, in terms of which cardio I advise them to do, it all depends on what their goals are, and their current physical condition.
One of the pieces of cardio I get clients to do very frequently is either road cycling, or cycling in the gym (most clients will do workouts in the gym). There are lots of benefits to using a bike and that’s what we’re going to look at in this post…
Does a cycling bike help to lose weight?
In short, YES, a bike can help you to lose weight. In order to lose weight you need to create a calorie deficit i.e. burn more calories than you consume. You could burn between 600-900 calories per hour cycling – the amount of calories you burn will depend on your intensity. For example you can increase intensity by going faster, or use more resistance.
Benefits of cycling…
There are plenty of benefits to cycling, which include…
Aerobic Fitness – cycling for 30-60 minutes at 50-60% of your maximum heart rate will do wonders for your aerobic fitness.
Weight Loss – we’ve already touched upon weight loss. But cycling for 30-60 minutes will burn a good amount of energy, which if combined with a good nutritious diet, will see you lose weight.
Improved Circulation – like with most cardio activities, cycling will improve circulation around the body, particularly the legs.
Stronger Legs – this is pretty obvious, as you are using your thighs and glutes throughout your cycling session they naturally get stronger and more toned.
Helps to reduce cellulite – cycling can have a positive impact on reducing cellulite, and is particularly good for targeting the buttocks (visit website for more information). This is thanks to improved capillary function and blood circulation in the lower limbs.
Different Types Of Exercise Bikes
At home, standard exercise bikes can be used, namely:
- Stationary mini-bikes
In terms of which one is the best to use, it all depends on personal preference. I’d recommend checking out online reviews before buying a fitness bike. Fitness bikes can be expensive (for a good one you’re going to be spending at least £700). So, if you don’t want to buy one, then it’s best to join a gym. In most gyms there’s a variety of different fitness bikes to choose from (spin bike, upright fitness bike, seated bikes, etc) so try them all and see which you like best.
Different Styles Of Training…
There are lots of ways to use a bike, for example you could do a HIIT workout, which stands for High Intensity Training – this is where you go flat out for a period of time, followed by a period of rest, or slow recovery cycling…
For example you sprint as fast as you can for 20s, then do slow cycling for 40s (to recover), then you go again, doing this for 10-20 mins. This is a great way to get fit in a short period of time. It’s ideal for footballers, and rugby/tennis players – due to the changes in pace. It’s also a great way to get in a workout without needing to spend hours in the gym.
The other way to use a fitness bike is to do LISS training which stands for Low Intensity Steady State Cardio – this is where you cycle at 40-50% effort, a bit like a walking pace, and the aim is to just burn calories. This is perfect for those people who are knew to fitness, or who are coming back from injury. It’s also good for elderly people, who still want to train, but don’t want to place too much stress on joints and muscles.
A good length of time to do LISS training is 45-60 mins. The intensity is medium to light, and the aim is literally to just cycle steadily and burn calories. LISS training is also done by bodybuilders when they are leaning down for a photoshoot, or to compete on stage – the low intensity favours fat burning, making it ideal for people wanting to get leaner.

domain: sports


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Any time a coach loses, more blame will be placed on him for his team’s performance than he deserves. Evaluating Hue Jackson is difficult to do after just eight games, and it is unfair to sharply criticize him due to his lack of weapons to work with.
However, when the game plan on offense is insufficient, this can be a knock on the coaching staff. The Browns came in to the game knowing that they would need to throw the ball a lot, but there still needs to be some semblance of balance. This was not existent, as Cleveland ran the ball just 15 times as opposed to their 51 pass attempts. This imbalance held true even though the Browns were averaging a respectable 3.8 yards per carry, and even though they were in the lead for a good part of the game.
Not only was the game plan poor, the Browns didn’t seem in sync on offense. This is a direct reflection on the coaching staff, as there was a clear lack of preparation.
Ray Horton clearly didn’t have his defense ready either. Mental lapses as what was seen on Powell’s third-and-ten touchdown run directly reflect preparation, a responsibility of the coaching staff. While the linebackers performed well, even they were not put in a good enough position to succeed, as they were too often forced to make tackles on running backs.
The team is a work in progress, without a doubt. But the coaches must at least maximize the talent they have been given. It’s no secret that the Browns lack pieces they need to become a contender. But all fans ask of the coaches is to make the most of what they have. There have been flashes of this at times, but the Browns took a step back in this category in Week 8.


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Heather Watson is young British tennis player who is considered as the future superstar. She already proved herself and became one of the best female tennis players of UK. Heather became the top-ranked British women player on WTA ranking in 2012 at an early age of 20 years. Same year Heather won his first WTA single title becoming first British female to do so since 1988.
Heather Miriam Watson was born on 19 May 1992 in Saint Peter Port Guemsey. Her mother is from Papua New Guinea and her father is an Englishman. Heather started to play tennis when she was 7 years old and went to Nick Bollettieri Tennis Academy in Florida USA when she was 12.
In 2006, Watson crowned as British U-14 Champion and following year she won the British U-16 Championship. In 2010 she started her professional tennis career. Watson achieved the highest career ranking on 25 February 2013 when she became the World No.39.
She has an amazing playing style and many people believe that it resembles with the great Martina Hingis. Watson’s amazing footwork, on-court talent and powerful shots makes her a perfect tennis star. In nutshell she is one of the most promising young tennis players in the world.
Heather Watson Profile
- Full Name: Heather Miriam Watson
- Date of Birth: 19 May 1992
- Place of Birth: Saint Peter Port Guemsey, UK
- Height: 5.7 feet
- Playing Style: Right-Handed
- Professional Career: 2010
- Country: UK
Heather Watson Wallpapers
Here in this photo gallery we have prepared some high quality wallpapers of this young tennis star;

domain: celebrity


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Organic, Vegan, Not fried, Gluten free, Sesame Free, Nuts Free, Egg Free, Peanuts Free, No Palm Oil, No Sulfites.
Ingredients: 78.5% buckwheat*, 5% quinoa*, 5% amaranth*, rice*, corn oil*, salt. Produced in a factory that also uses milk* and soy*. *From organic farming.
Gluten Free | Egg Free | Organic

domain: food


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The content has been shared, if you want to share this content with other users click here.
Belize's agriculture and fisheries ministry expects to present the final draft of an irrigation improvement policy to congress by October or November this year, local coordinator for the Food and Agriculture Organization (FAO), Ricardo Thompson, told BNamericas.
The new policy, being drawn up with technical support from FAO, aims to develop a strategy to improve the country's irrigation sector, focusing specifically on water harvesting, drainage, and implementing more efficient irrigation systems.
"We essentially aim to form an irrigation policy that supports an agriculture sector geared toward producing commodities for export," Thompson said, adding that the plan will also help the country prepare for the effects of climate change.
Under the new plan, the ministry expects to grow both public and private sector investment in irrigation.
"The kind of collaboration we see between the private and public sector is setting up an enabling environment so that we can make the investments that are required. It has to be a dual effort [...], not just public or just private," said Thompson.
Planned incentives for private investment in irrigation include providing affordable credit to investors at a competitive interest rate, which in Belize is 8-10%, according to Thompson.
Another incentive is tax exemptions, and finally providing technical support for firms looking to participate in the sector.
Private sector participation will involve technical support to develop a more uniform distribution of water nationwide, as well as for developing investment plans to create profitable projects.

domain: agronomy


2007 Chevrolet Cobalt SS Supercharged 2dr Coupe (2.0L 4cyl S/C 5M)
Great car for the money. Designers at GM finally understand what the GenXers want in a car, and for the most part have delivered. My only tiny gripe is rear visibility, as the trunk lid is higher than what I'm used to.
The little 2.0L engine pulls with that supercharger attached!


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WhatsApp Business Account
Combine the history of Hanoi with the natural landscape of Sapa and the vast awesomeness of World Heritage protected Ha Long Bay. Each destination on this itinerary brings its own story, beauty, and a peacefulness that leave you in no doubt that you are immersed in the wonder of Vietnam.
Upon arrival at the airport you’ll be escorted by car to your accommodation in Hanoi.
The remainder of your day will be spent at leisure.
Start your trip with an early morning visit to Hoan Kiem Lake where you’ll see the locals go through their morning tai chi and aerobics routines, and visit the Ngoc Son Temple.
Continue with a walking tour of Hanoi’s Old Quarter, visiting St Joseph Cathedral, Hoa Lo Prison and Huu Tiep Lake, where the wreckage of a US B-52 bomber can be seen.
After lunch, visit the picturesque Temple of Literature, then stop for an afternoon beer with the locals. In the evening, you’ll board the Victoria Express train for the overnight journey to Lao Cai. in your private sleeper cabin.
You’ll arrive in Sapa in the early morning and check into your lodge on a quiet hilltop in the Sapa Valley.
After lunch, head out to explore on a guided walk through Sapa’s gardens, rice paddies, forests and mountain villages, home to ethnic hill-tribes.
This morning you’ll venture off the beaten track to explore the Hoang Lien National Park. You’ll hike through valleys next to mountains and waterfalls, and weave through local villages where you’ll see farmers working their land.
After lunch, you’ll explore the village and watch arts and crafts demonstrations. You’ll also have the chance to swim in the river before returning to the Victoria Express Train for your overnight journey back to Hanoi.
Once back in Hanoi, you have the opportunity to pop back to your hotel to refresh before being driven to Ha Long Bay, where you’ll board your cruise ship to sail around the UNESCO-listed natural wonder.
Explore Surprise Cave by bamboo boat or kayak, indulge in a spa treatment, or enjoy on-board activities such as fruit carving, masterchef competitions or tea ceremonies.
Start your morning with a sunrise tai chi session on the deck of the ship, before continuing around the bay. There will be plenty of opportunities to head off the boat to explore, including kayaking excursions and cycling trips.
Back on board, enjoy drinks, a barbeque buffet, watch movies or stargaze.
Enjoy another gentle start to the day with tai chi as your boat makes its way slowly back to port, stopping to explore the Cua Van floating village.
Indulge in a Vietnamese tea ceremony before disembarking and returning to Hanoi to catch your onward flight.
Enjoy an early morning visit to Hoan Kiem Lake and the Ngoc Son Temple
Return to the golden age of travel with an overnight trip on the Victoria Express Train
Explore the dramatic scenery and ethnic hill-tribe villages of Sapa
Cruise around the emerald waters, towering limestone pillars and tiny forest-topped islets of Ha Long Bay
Start your day with sunrise tai chi on the sundeck of your boat
Get in touch with our Lightfoot Travel experts and they will create a bespoke itinerary designed to your exact needs and budget.
We won't take you to the usual tourist traps, instead we'll introduce you to people that show you the true side of a country. With our contacts in each destination, we can arrange for you to meet locals away from the crowds and ensure an authentic experience.
You can rely on our extensive first-hand knowledge and years of experience in the country you’re visiting. We use only the best expert guides, and provide insider tips on the local customs, and everything from vibrant festivals to hidden Himalayan monasteries
Your vacation will be as unique as you are. By getting to know you and what makes you tick, we fuse our wealth of expertise and a deep understanding of our destinations to create unique day by day itineraries that are built around you.

domain: travel


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The Firing Range is a new feature in Call of Duty: Modern Warfare Remastered. It is similar to the Virtual Firing Range in Call of Duty: Advanced Warfare, being a way for the player to test out their weapons in Create-A-Class. The firing range is the one in F.N.G. with some changes.
However, it has several notable differences: weapon types are only usable in certain lanes of the range, this can be seen through the lightbar on a lane. Only primary weapons, their Grenade Launcher (if the assault rifle has one attached), and sidearms can be used to activate the lanes (switching to a Perk 1 equipment while a lane is active will deactivate it, going up to one with a Perk 1 equipment will simply not activate the lane). There are five lanes available: the first one is for shotguns, the second one is for SMGs, the third one is for assault rifles, the fourth one is for LMGs and the final one is for sniper rifles.
Players can't change their loadout while in the range. To do this, the player must exit and choose another loadout, then enter the range again.
Trivia[edit | edit source]
- The player has God mode active while in the range. The player can't be damaged or killed by explosives, also can't be affected by tactical grenades.
- When low on ammunition, equipment, or grenades, the game will fully replenish them automatically. So the player basically has infinite ammunition and equipments.
- The watermelon the player can knife can't be destroyed by other things.
- In Traditional Chinese version, this system is mistranslated as 射程 (a weapon's range) instead of 靶場 (shooting range).
[edit | edit source]


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Hot Box: TV to talk about
We haven't seen the last of Rosie O'Donnell on network TV. Two NBC executives said yesterday they are talking with O'Donnell about a prime-time show on MSNBC, possibly in the 9 p.m. weeknight slot, opposite Larry King Live on CNN and Hannity & Colmes on Fox News.
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Guess Who: We haven't seen the last of Rosie O'Donnell on network TV. Two NBC executives said yesterday they are talking with O'Donnell about a prime-time show on MSNBC, possibly in the 9 p.m. weeknight slot, opposite Larry King Live on CNN and Hannity & Colmes on Fox News.
Amazing: A TV perennial, The Amazing Race, returned for its 12th season on CTV and in simulcast garnered 2.14 million viewers, making it the most watched of Sunday evening. An hour before on CTV, Cold Case in its 100th episode outing had 1.44 million viewers. And at 9 p.m., 2.05 million viewers watched a new simulcast episode of Desperate Housewives on CTV.
Afraid: Who's afraid of the writers' strike? Not Larry David, who long said he'd only renew his series Curb Your Enthusiasm year by year. Now he's talking about renewing for three more seasons at once. Why the big change of heart? David has been telling friends he just likes doing the show. As co-creator of Seinfeld he made a lot of money but had no recognition. Prickly and difficult to deal with, he was the inspiration for Seinfeld's George Costanza character.
Finale: The buzz all season has been about the finale of ER. Perhaps the great stars of its past like George Clooney could come back for one more show? Well, ER creator Tom Wells told Daily Variety he's talking one more season for the medical hit. But ratings have been declining and it costs about $5 million per hour – twice the cost of a first-season hour-long drama. NBC is asking for reductions of $1 million a week.
- Daesh is doomed, Canada’s top general says during dramatic visit to Iraq
- 80 arrested in province-wide child porn investigation
- Skull found in Toronto field identified as homicide victim Rigat Ghirmay
- Surveillance and predictive policing: Welcome to the 'safety state’ of tomorrow
- Pressure mounting as controversial GTA West highway decision deadline looms
- New research offers most detailed ever look at human gut
- Video Investigators looking into possible drug overdose in Prince’s death
- Wynne says Horwath stalling on reforms because of Cornerstone ties


RMS has estimated Hurricane Matthew will produce insured losses of US$1.5 billion to US$5 billion for the United States and US$1 billion to US$3 billion in the Caribbean, making it the reinsurance industry’s costliest Atlantic hurricane since Sandy four years ago.
Only one of 10 RMS event reconstructions generated a U.S. loss in excess of US$4 billion, notes a statement Friday from the catastrophe risk management firm.
“However, the company advises there is still a small possibility that losses could reach as high as US$5 billion,” RMS reports, adding estimates are based on reconstructing Matthew’s hazard from both remote and on-the-ground damage surveys.
Hurricane Matthew caused significant damage and loss of life in Haiti, Cuba and the Bahamas before reaching the U.S. Beyond the effects at landfall, the storm followed a path just off the southeast U.S. coastline for two days, drenching much of coastline along its track with torrential rains.
Approximately 70% of the estimated U.S. loss – which does not include National Flood Insurance Program or public buildings and infrastructure losses – is to residential lines, RMS notes. Storm surge-driven coastal flooding is estimated to contribute approximately 30% of the all-lines loss.
The latter includes “coverage leakage and an escalation in claims severity for wind-only policies in situations where wind and water hazards co-exist in residential lines of business,” the statement explains.
Of the estimated Caribbean loss, RMS anticipates that the highest proportion will emanate from the Bahamas.
Loss estimates for both the U.S. and Caribbean from Hurricane Matthew include property damage and business interruption, caused by wind and coastal flooding upon residential, commercial and industrial lines of business. For the U.S, auto lines of business are also included.
For the U.S., surveys indicate “severe flooding, driven by storm surge and the record rainfalls will prove to be the largest driver of economic losses in the southeast U.S.,” the statement notes.
“However, at this time, the RMS loss estimate excludes damage associated with inland flooding, since a post-event estimation of the impact of inland flooding can only be completed once all inland flooding has concluded – and some rivers remain at flood level,” the company adds.
While RMS does not expect the private insurance industry to receive a high number of flood claims, it does anticipate “the insurance industry will cover inland flood losses incurred by commercial and industrial exposure, which tend to be covered as part of multi-peril or all risks policies.”
Noting a degree of uncertainty exists around loss estimates in the immediate aftermath of a hurricane, “Matthew’s track parallel to the southeast U.S. coast put significant amounts of exposure at risk from damaging winds and surge, which exacerbates this uncertainty,” says Tom Sabbatelli, product manager in the RMS hurricane modelling team.
“Even small variations in our 10 wind and storm surge reconstructions over the wide swaths of exposure can have a significant impact on the estimated loss,” Sabbatelli cautions.


BBN Configuration Database
Configuration database for BBN Qubit Measurement Framework. Used by both Auspex and QGL as a shared, versioned, means of storing instrument, qubit, and filter configurations. Based on SQLAlchemy framework.
Upgrading your channel library to a new version
We use alembic to facilitate migrations. Examining the
url.sqlalchemy field in alembic.ini you can see the database that is being tracked by default.
sqlalchemy.url = sqlite:///BBN.sqlite
These do not always work with SQLite due to the inability to alter the tables in certain ways.
In the simplest case alembic can be run as follows:
bash alembic upgrade head
For information on how to generate your own migrations, please see alembic/README.
Download the file for your platform. If you're not sure which to choose, learn more about installing packages.


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|April 22, 2014 - The International Biscuit Festival announced today that it has completed the selection of artwork for the Biscuit Art Exhibition 2014. The selected works will be exhibited throughout the month of May at Rala, Bliss Home and Coffee & Chocolate in downtown Knoxville. The Biscuit Art Exhibition features Biscuit-inspired artwork, including paintings, photography and folk art.
The exhibition was juried by David Butler, the executive director of the Knoxville Museum of Art, and Cindy Spangler, the former Collections Manager for the Ewing Gallery at the University of Tennessee, Knoxville. Submissions were received from across the United States.
One Best in Show award and two Merit awards will be presented at the Exhibition Opening Reception on May 2, 2014 6-9 p.m. A total of $2,000 in cash prizes will be awarded. Announcement of winners will be at 6:30 p.m. outside Rala and Coffee & Chocolate with a Biscuit Reception to follow.
All selected artworks will be for available for purchase starting May 2, 2014 at 5pm exclusively at biscuitfest.com/art.
The International Biscuit Festival celebrates that most perfect of foods - the Biscuit. The Festival draws over 20,000 biscuit lovers to downtown Knoxville each year and was selected the #1 Food Festival in the U.S by Livability.com. The event has been featured in Southern Living, Garden and Gun, the New Yorker, the New York Post, as well as CNN.
For more information about the International Biscuit Festival, go to biscuitfest.com, or contact us at firstname.lastname@example.org.


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When Chris Lake and Chris Lorenzo reunited as Anti Up on their last single, “Sensational,” we knew there had to be more rounds in the chamber. Thankfully, our predictions were right and the reignited house duo have dropped of a chaotic new cut titled, “Shake.” This new single also comes with news of a full length album set to drop on sometime in August, according to a recent Twitter Q&A.
This newest offering, “Shake,” is quintessential Anti Up. A punky call-out builds to a sensory overloading drop of hollow metallic synths and earth shattering bass, all the right things are shaking, and we. Can’t. Stop. Stomping. We can’t wait to see what an Anti Up album brings.
Stream Anti Up’s hectic new single, “Shake,” below. Enjoy!


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"Creux du Van", a natural rock arena of immense proportions, is located at the border of the cantons of Neuenburg and Vaud. Impressive 160 meter high vertical rock faces surround a four kilometer long and over one kilometer wide valley basin.
Since 1951 the former grammar school at the city park houses around 600 pictures and drawings by Swiss, German and Austrian artists. We owe this to the Winterthur art patron Oskar Reinhart.
Impressive views as seen from the Piz Palü – above Bellavista and on to Piz Bernina. Simply stand back and marvel, or delight in some kind of adventure: Diavolezza is the perfect spot for both.
Everything is nature-oriented in the Swiss National Park in the Engadine. All this can be enjoyed in an area of over 170 square kilometers. Thanks to 80 kilometers of hiking paths, nature trails and excursion destinations for children and families; everyone can have a good time in this extraordinary park.


ELIMINATES THE NEED TO DRAIN WATER WHEN WINTERIZING YOUR IN-GROUND SWIMMING POOL! This pool valve prevents water from entering the return lines with a unique one-way valve system. Simply replace your current "eyeball" return fitting with this valve when...
1PC OF 4GB 204p PC3-10600 CL9 16c 256x8 DDR3-1333 SODIMM. Genuine CMS brand, By CMS. Compatible With: AOpen Digital Engine MP65-DU Series AOpen Digital Engine MP65-UI Series AOpen Gigital Engine MP67-D Series AOpen Gigital Engine MP67-DI Series AOpen MP67-DU Series Maximum Memory: 8 GB Expansion: 2 Sockets Maximum configurations require a 64-bit operating system.
Water-repellent woven fabric construction provides dry comfort. Mapped with synthetic down insulation for additional warmth. Zippered chest pocket on reverse side for storage; Reversible style. Hand warmer pockets provide additional warmth; Unisex sizing. bluesign approved for a reduced impact on both people and the environment.
Medium-regular. Blue sign Approved Water-Repellent Polyester Woven Fabric and Printed Woven Fabric on Reverse Side. Mapped with Synthetic Down Insulation Throughout. Zipper Closure Chest Pocket on Reverse Side and Hand warmer Pockets. Reversible Style.
Quick-drying 100% polyester DRYRIDE Thermex brush back fleece construction for breathable warmth. Raglan sleeves for optimal range of motion; Jersey hood lining provides additional warmth. Kangaroo hand warmer pocket for warmth and storage; Thumbhole cuffs keep the sleeves locked into place. Self-fabric cuffs and hem for style. Burton classic fit is not too baggy and has room to layer; One-year warranty.
DRYRIDE 2-Layer Polyester Printed Plain Weave Fabric [10,000MM, 5,000G] [Gigit Surf Stripe Colorway]. DRYRIDE 2-Layer Polyester Printed Oxford Fabric [10,000MM, 5,000G] [Cosmos Petal Paisley Colorway]. DRYRIDE 2-Layer Polyester Printed Plain Weave Body Fabric with Polyester Denim Twill Fabric on Sleeves [10,000MM, 5,000G] [Mijita / Denim Colorway]. DRYRIDE 2-Layer Polyester Twill Semi-Dull Fabric [10,000MM, 5,000G] [All Other Colorways]. Mapped with Thermacore� Insulation [120G Body / 100G Sleeves / 80G Hood and Collar].
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Fred says Ciao Bello! If you look close you can see the famous architechtural Italian elements like the famous leaning tower of Pisa and the Trevi Fountain of Rome. The polo is made out of 95% cotton and 5% stretch. Did you know that Fred's polo's are all made with GOTS certification? This means we use sustainable production processes that meet the Global Organic Textile Standards. The polo would be perfect if you combine it with a matching bermuda short or chino!


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It is reported that IATA (International Air Transport Authority) has forecasted a staggering 8.2 billion air travellers in 2037 even if the industry is Airports facing difficulties with huge set back due to the novel coronavirus pandemic situation. There are many airports that will definitely surprise you with their postal codes like hotels, restaurants spas, and mails. Nowadays airports of the world are a lot more than just catch flights.
If you are a frequent traveller then you may notice such never-ending escalators and also about the hallways at airports and also to reach the gate bin such airports that are seeming like a herculean task.
Here is the list of Top 10 Largest Airports in the World:
10. Suvarnabhunmi Airport (BKK)
This airport is also known as Bangkok airport and also one of the biggest airports in South East Asia stretches across 8,000 acres. The new airport is serving an average of 63 million passengers each year. The airport was opened in 2006. The construction of the airport had taken around $5 billion. It contains two runways capable of handling 64 flights within one hour.
9. Cairo International Airport(CAI)
This airport is the world’s ninth-largest airport and also the only African Airport. It is situated in Heliopolis, Egypt having the capacity to handle 15 million passengers each year of 2017. It is spread across 37 square kilometres n Heliopolis. Now it has been served as the base of the US Air Force until 18963 while African Civil Aviation took over the operations of the airport under the control.
8. Shanghai Pudong International Airport (PVG)
This is mainly the world’s eighth-largest airport and also the second biggest in China. It has an area of 10,000 acres and also has been served 74 million passengers in 2018. In China, it has such largest mainland.
7. George Bush International Air[port (IAH)
This airport is mainly located in Houston, Texas that has been spread areas 10,000 acres. This airport is smaller in size in comparison with Washington Dulles International Airport. It can handle 45 million passengers that are just double the passenger’s traffic.
6. Washington Dulles International Airport (IAD)
This airport is mainly the sixth biggest and one of the largest airports in the US. It has been built in Fairfax and Loudoun Countries in Virginia. It spread across 13,000 acres. The name of the airport has been fixed after John Foster Dulles, 52nd US Secretary of State. It can serve around 24 million travellers a year.
5. Orlando International Airport
This airport is situated in Orlando that is mainly the home of Disney World got a footfall of around 58 million visitors every year and also has many of these visitors coming by flight.
It seems that the airport has been planned for 40 years ago by covering 60 square kilometres. This airport approximately has been served over 50 million passengers in 2019.
4. Dallas/Forth Worth International Airport(DFW)
This airport ranks fourth on our list with its own Zip code. This airport is spread around 27 square miles. It also has been served more than 260 destinations.
3. Denver International Airport(DEN)
This is the world’s third-biggest as well as the biggest airport in the US. It has been spread along the 52.4 square miles. It is also one of the largest employers in Colorado with more than 52,000 staff.
This airport has mainly 23 airlines companies with such flights over more than 215 destinations. In 2019, this airport serves more than 69 million travellers.
2. King Fahd International Airport(DMM)
It is mainly the world’s second-largest airport located in Dammam, Saudi Arabia. It seems that the terminal area has been made up of over 3.5 million sq. ft and with a total area of 780 sq. kilometres. It also can handle m approximately 12 million travellers each year.
There is the Mosque that can accommodate over 2000 worshippers at the time. There are also other luxurious amenities available containing a Hilton Hotel inside the grounds.
1. Beijing Daxing International Airport (PKX)
This world’s largest airport. The construction takes $11 billion, Beijing Daxing International Airport for the terminus building spread across mind-boggling 7.5 million sq. ft. Totally, the airport land area is approximately 18 square miles. There are also several solar panels with water management systems, and also has been wasting the heat recovery systems has been installed in the airport. It is estimated that by 2040 this airport become one of the busiest airports with more than 100 million passengers.
A big thanks for the source


JamBase Features, Newswire & Reviews
Julian Casablancas | 11.17 | CAJulian Casablancas of The Strokes leaves the booze behind and takes his solo act...
I'm a longtime strokes fan. I just listened to this album, and it is really good. But this review makes it seem like he and the band just need some time to learn to gel together. I would definitely like to see him.
This looks like a pretty accurate review. Save your money.
I like the new album a lot - and have dug Albert Hammond's solo work and Little Joy, too, but when The Strokes were rolling on all cylinders, it was something really special.
I would go check it out if it comes by. Not on the top of my list or anything, but I can see it being good
but who knows


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How to Purchase a Hotel Bond
Located near Bushnell Park, Hartford’s Hotel Bond was built in two stages in 1913 and 1921. The opulence of the hotel made it one of the top choices for Connecticut tourists and locals. In its heyday, the Hotel Bond was considered to be the finest hotel in the city. This historic landmark now serves as a museum and a place to stay. If you’re interested in history, the Hotel’s interior is as charming as its exterior.
When you buy a hotel bond, you’re buying a part of the hotel in exchange for an equity stake. These bonds are sold to hotels by a third party and don’t expire until year-end 2021, but they’re usually more flexible. The terms of the Hotel bond vary from hotel to property. The most common types of bonds last around five years. If you need a room for a long vacation, you may want to purchase a longer term bond that expires sooner.
This type of bond is similar to a gift certificate. You’ll pay a lower rate today and then receive a higher discount later. A hotel bond can also be used for other purposes, such as booking an airline ticket or buying a souvenir. If you’re traveling to a hotel with a bond, you might have to purchase a separate ticket for the day you’re going to stay.
A hotel bond can be an excellent way to invest in a hotel.
Hotel Bond is one of the most affordable ways to enjoy a stay in the city. It’s located less than a kilometer from the Nairobi National Museum and 300 metres from the Odeon Cinema. It has free parking for its guests and has a bar and restaurant. Room rates are reasonably priced and include free continental breakfast, a kitchen with a fridge, and a flat-screen TV. The hotel is also within walking distance of the Jamia Mosque.
Although the Hotel Bond offers a flexible cancellation policy, there are restrictions. If you’re unable to use the hotel you booked, you must cancel your reservation at least a few days before you check-in. In most cases, you can cancel your reservation up to a few days before check-in. If you’re traveling with your family, it’s best to get a room in advance, so that you can avoid missing out on any activities.
To purchase a hotel bond, go to the hotel’s website. 아파트담보대출 It’s easy to buy them online and most of the time, you can contact the hotel directly. Some hotels even have an email button on their page, so you can contact the hotel directly. Some hotels require that you purchase a hotel bond through the hotel’s website. However, it’s worth keeping in mind that if you choose to buy a hotel with a bond program, you’re essentially guaranteeing yourself the highest possible satisfaction.
It can be purchased directly from the hotel or from a third party.
This means that there’s no middle man that could take your money and then make a profit off of it. This makes it the perfect travel option for many travelers. The hotel bonds are issued by the hotel, and the hotel itself provides the services. There are many advantages to purchasing a hotel bond, including its flexibility and low cost. Besides, you’ll be able to save up to 50% on the price of a stay.
The hotel will not sell the bonds to you, but will let you purchase them directly through a form. It is important to know that buying a hotel bond is not guaranteed in the event the property is shut down, but it can be a great way to ensure that you’ll always have a place to stay when you visit.
The idea behind hotel bonds is to help struggling hotels and resorts remain in business. It helps the hotel stay as well as the local community by helping the hotel stay. It’s also a great way to promote the hotel. You can also sell your own bonds on the internet. These are sold in a variety of ways, and the key is to find one that suits you.