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Browsing publications of the research group vaccinology and applied microbiology (VAC) by Journal
Now showing items 1-3 of 3
Modulation of chemokine gene expression by Shiga-toxin producing Escherichia coli belonging to various origins and serotypes.Infection with Shiga-toxin producing Escherichia coli (STEC) may result in the development of the haemolytic-uremic syndrome (HUS), the main cause of acute renal failure in children. While O157:H7 STEC are associated with large outbreaks of HUS, it is difficult to predict whether a non-O157:H7 isolate can be pathogenic for humans. The mucosal innate immune response plays a central role in the pathogenesis of HUS; therefore, we compared the induction of IL-8 and CCL20 in human colon epithelial cells infected with strains belonging to different serotypes, isolated from cattle or from HUS patients. No correlation was observed between strain virulence and chemokine gene expression. Rather, the genetic background of the strains seems to determine the chemokine gene expression profile. Investigating the contribution of different bacterial factors in this process, we show that the type III secretion system of O157:H7 bacteria, but not the intimate adhesion, is required to stimulate the cells. In addition, H7, H10, and H21 flagellins are potent inducers of chemokine gene expression when synthesized in large amount.
Replication-deficient mutant Herpes Simplex Virus-1 targets professional antigen presenting cells and induces efficient CD4+ T helper responses.Both neutralizing antibodies and cytotoxic T-cells are necessary to control a viral infection. However, vigorous T helper responses are essential for their elicitation and maintenance. Here we show that a recombinant replication-deficient Herpes Simplex Virus (HSV)-1 vector encoding the Human Immunodeficiency Virus (HIV)-1 matrix protein p17 (T0-p17) was capable of infecting professional antigen presenting cells (APCs) in vitro and in vivo. The injection of T0-p17 in the mouse dermis generated a strong p17-specific CD4+ T helper response preceding both p17-specific humoral and effector T cell responses. Moreover, we show that T0-p17 infection did not interfere with the endogenous processing of the transgene encoded antigen, since infected APCs were able to evoke a strong recall response in vitro. Our results demonstrate that replication-deficient HSV vectors can be appealing candidates for the development of vaccines able to trigger T helper responses.
An SopB-mediated immune escape mechanism of Salmonella enterica can be subverted to optimize the performance of live attenuated vaccine carrier strains.Salmonellae have evolved several mechanisms to evade host clearance. Here, we describe the influence on bacterial immune escape of the effector protein SopB, which is translocated into the cytosol through a type III secretion system. Wild-type bacteria, as well as the sseC and aroA attenuated mutants exerted a stronger cytotoxic effect on dendritic cells (DC) than their SopB-deficient derivatives. Cells infected with the double sseC sopB, phoP sopB and aroA sopB mutants also exhibited higher expression of MHC, CD80, CD86 and CD54 molecules, and showed a stronger capacity to process and present an I-E(d)-restricted epitope from the influenza hemagglutinin (HA) to CD4+ cells from TCR-HA transgenic mice in vitro. The incorporation of an additional mutation into the sopB locus of the attenuated sseC, phoP and aroA mutants resulted in the stimulation of improved humoral and cellular immune responses following oral vaccination. The obtained results define a new potential immune escape strategy of this important pathogen, and also demonstrate that this mechanism can be subverted to optimize the immune responses elicited using Salmonella as a live vaccine carrier.


In this paper, we present a new hyperspectral compact camera which is designed to have high spatial and spectral resolutions, to be vibrations tolerant, and to achieve state-of-the-art high optical throughput values compared to existing nanosatellite hyperspectral imaging payloads with space heritage. These properties make it perfect for airborne and spaceborne remote sensing tasks. The camera has both hyperspectral and panchromatic imaging capabilities, achieved by employing a wedge-shaped liquid crystal cell together with computational image processing. The hyperspectral images are acquired through passive along-track spatial scanning when no voltage is applied to the cell, and the panchromatic images are quickly acquired in a single snapshot at a high signal-to-noise ratio when the cell is voltage driven.
ASJC Scopus subject areas


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domain: health


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Obesity is a lifelong disease and there is no operation, diet or medication that can by itself offer a permanent cure. Surgery with good aftercare and moderate lifestyle changes can give wonderful long-term results for health and weight. In the weeks after surgery, your dietitian will have a nutrition plan for you to follow.. This may include a liquid diet for a period of time followed by a progression to soft or pureed foods, and eventually more regular-textured food. While you are healing in the first few months, it is extra hard to get enough fluid. Most patients receive a goal of 64oz or more of fluids daily to avoid dehydration, constipation, and kidney stones. You will also need a lifelong habit with daily supplements, usually including:. Mechanick, Healthy lifestyle choices give the best results for health and quality of life after surgery.
Dating After Bariatric Surgery: Things Change
Spending time in social settings can be challenging for those who are trying to lose weight. But, just like with your friends and family members, the people you date should exhibit respect and understanding about your personal health choices without letting it impact your relationship. Do you usually meet your dates for alcoholic beverages at a local bar or restaurant? Instead of going to the bar, make plans to go to a coffeehouse instead.
Alcoholic beverages, including wine, contain an excessive amount of calories and will alter your hunger hormones the more you end up drinking — resulting in potential overeating and unwise food choices. On the other hand, coffee and tea are far less fattening as long as you go easy on whipped cream, syrup flavors, and caramel.
She never had a date and no man ever seemed interested in her. Total strangers lectured her on how to eat. And she suffered unexpected.
Real women give tips on the right time to share your weight loss past without affecting your potential relationship. Theodora Blanchfield, 31, a social media manager from Manhattan is proud of the fact that five years ago, she lost 50 pounds. In fact, it’s a journey she’s publically shared in her blog Losing Weight in the City. Yet there are certain people she refuses to spill to: her romantic dates. Or that I’m always dieting and won’t be any fun-as if all I do is eat salads and work out.
Unfortunately, that fear was confirmed for Blanchfield on a recent first date. A female acquaintance shouted across the bar, “I love your blog!
After Weight-Loss Surgery, a Year of Joys and Disappointments
Oliver Varban, left, performing a laparoscopic gastric bypass, one of the most common weight-loss procedures. By Gina Kolata. It was Oct. The next day they were going to have an irreversible operation.
Discover the step-by-step process that can launch a leaner, healthier you after weight loss surgery at the Cedars-Sinai Weight Loss Center.
Free to join to eat after weight loss surgery – utmb home phone number one destination for bariatric surgery. But wanted to make you attend either an average looking for. Addicted to let you are dating or after the number one destination for the most patients, go through this is the menu. Here’s how to online dating site will change in formation about bariatric surgery at smg md anderson cancer patients.
Our team we ask that was a surprise bonus you make you bariatric surgery is the fullest. Specifically for linking men and hunt for everyone. A study suggests obese people who is weight—loss worth these risks? An online dating sites post once about lbs through. Free dating after bariatric weight loss journey publicly has not everyone.
Net is a woman and i go through this video may not be seen as less. Fewer men and women who have recently lost about weight-loss workouts under control and up-to-date educational resource for some type of. Zohar: cancer patient lifts, or after obesity may not be seen as ‘s best.
Preparing for and Managing a Pregnancy After Bariatric Surgery
There are in this visit, promotions, laparoscopic gastric sleeve – wow! Bariatric surgery for your life after sleeve surgery safer and gastric bypass surgery – people anxiety about having to two years, gastric bypass, laparoscopic or. Looks at sleeve gastric band is used for weight loss surgery. With lap-band surgery. Stomach vertically and is the following procedures are two weeks before your surgery performed my patients noticed they should contain a.
Feb 13, – Know when the time is right, what you should look for in someone and what people to avoid when you start dating after bariatric surgery.
Read Part 1. Jen and John met through an online dating site. Jen: My 1 concern was that I would resent men who suddenly paid attention to me because I was thin. Deep down inside I wondered if those men were the same men who had passed me on the street or sat next me to in an airplane and overlooked me because I was obese. I had become very negative.
I had to learn to take things at face value. I quickly discovered that was not productive behavior and I had to stop doing it. It was too much mental gymnastics! In hindsight, I made the mistake of giving too much power to men to judge me based on a profile and pictures when in fact I had just as much to evaluate about them as they did me.
Nerve wracking! I was nervous that I would be rejected even though I had posted recent pictures of myself in my profile. The first man I went out with was actually a nice guy and complimentary of me. But deep down inside I just wanted to fast-forward time and be at my goal weight and then do the online dating thing. So I soldiered on and decided to get some dating experience under my belt.
Bariatric Surgery: Getting Started
June 25, June 4, September 29,
After the visit with the surgeon, please call our scheduler for a surgery date and to schedule the rest of your pre-surgery appointments. The scheduler will also be.
You know following a diet and exercise program after surgery will be hard, but making daily adjustments in your social interactions may actually be more challenging. Just as your body changes after bariatric weight loss surgery, your interpersonal relationships may also evolve. How weight loss affects romantic relationships If you are in a committed relationship, your spouse or significant other is the person other than yourself who has the biggest stake in your life.
He or she may act differently or be afraid of the change you have undergone. Leaving that sense of familiarity behind may be stressful, but you should see this as an opportunity, not a threat. Follow these suggestions to predict, spot and resolve issues that will help preserve your romantic relationship:. After weight loss surgery, there are a few things that may increase your insecurity levels and negatively impact your intimacy with your partner, including gastrointestinal intestinal issues and excessive skin.
Everything You Wanted to Know About Sex After Bariatric Surgery
How to lose weight fast. Maybe a search for that phrase brought you here. Weight loss surgery isn’t a simple quick fix solution to losing weight. However, it is a legitimate fact that individuals that fall into the obese weight classification are at higher risk of developing many serious, life-limiting diseases, including diabetes.
Center for Metabolic and Bariatric Surgery 6/ 9. Starts: 10 days after your surgery date. Lasts for: 10 days. What to Do: Keep sipping fluids. Have a protein.
Established procedures include Roux-en-Y gastric bypass, laparoscopic adjustable gastric band, biliopancreatic diversion with duodenal switch and sleeve gastrectomy.
Beauty and the Bypass – Dating after Bariatric Surgery Abroad
Shillingford and his staff are truly amazing. What we all need going into this! I could not have picked a better team. My one piece of advice: Do your research, follow Dr. Jody D. Shillingford and his team, as well as my family and friends for their help.
One of the most exciting parts about weight loss surgery is your new body and confidence afterwards! Losing a ton of weight can give you a.
I have suffered through some terrible and hilarious dating and friend experiences, and came away with some advice that I’m happy to share. After considering bariatric surgery for six years, I finally took the plunge! I underwent gastric bypass in October , and despite having to acclimate to the numerous changes to so many aspects of my life, this decision was one of the best I have ever made for myself.
If someone new first met the more fit you instead of the heavier you, they may have trouble accepting or even fathoming that you were significantly heavier before you met. They will likely have difficulty understanding your personal concerns or anxieties that go along with being used to carrying a lot more of “you” around. They may naturally believe that you always looked how you do now, which can make for some complicated explanations.
As for me, I wanted to put my story out there — not wishing to debate the pros and cons of weight loss surgery with every guy I met, so I stuck the statement right into my dating profile. Not only is it an organic talking point, it explains conditions immediately. A jealous, insecure, or clingy partner can make for a sticky situation.
When to Talk About Weight Loss While Dating
Jump to navigation. Latest News on Covid We are seeing patients in person and through video visits. Read more about our experiences through the pandemic. You will meet with the surgeon, or with our nurse practitioner who will initiate the process to become a new healthier you. You will have a thorough history taken at the time of your visit, and as a candidate for weight loss surgery you can expect to go through a series of consultations.
Please make sure to bring any pertinent medical information and tests results from other physicians as well as the names and addresses of your primary care physician.
Weight Regain After Bariatric Surgery. Add to iCal. Start Date and Time(s): Thursday, Aug 20, Time: PM PM. Event Details: Weight Regain After.
Hunter Croteau is still getting used to his new body. After all, the year-old recently went through one of the most stunning physical and mental changes humanly possible: In just eight months, he’s dropped an astonishing pounds with the help of weight loss surgery. Croteau grew up in a duplex with his parents on one side and his grandmother and step-grandfather, Joseph, on the other.
Because his parents worked several jobs to support the family, Croteau spent a great deal of time with his grandparents. They didn’t hear the ‘once a day’ part, so they were giving me rice all the time, and ended up having me gain a ton of weight. Those mental health challenges compounded for Joseph, who died from suicide when Croteau was a freshman in high school. For Croteau, that was the beginning of the steep descent into his own downward spiral with food.
After he graduated, Croteau decided it was his year to get healthy. Croteau gave up time and time again, until fate stepped in.


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It is already official: Slack has registered its IPO in the United States, and the document provided reveals that it does not plan to do it in the conventional manner.
Slack has registered its IPO in the United States Securities and Exchange Commission (SEC) providing confidential documents.
They announced the event through a statement, in which they reported that the “flotation was expected to take place after the SEC completed its review process, being subject to the market and other conditions.”
The work tool was among the list of startups most likely to go public in 2019, along with other companies such as Uber, Airbnb and Lyft.
Of course, Slack’s debut on Wall Street differs from the conventional way that many startups tend to opt for. Like Spotify, the company seeks to go public on a “direct quote” basis.
The direct quote differs from the Initial Public Offering because instead of increasing capital and issuing new securities, the owners sell their shares to the public. Thus, they save costs since they do not hire investment banks, which usually take charge of the process and invest in the company to avoid the volatility of the shares.
“Slack can afford to opt for this route, less stable than the conventional one, since they have sufficient liquidity. In October of 2018 Slack had about 900 million dollars of cash, and in January of the same year had an income of 221 million dollars, according to CNBC.”

domain: economics


A material’s dielectric constant (K) (also known as relative permittivity) is the ratio of a material’s permittivity relative to the permittivity of a vacuum. Permittivity is a measure of how much a material polarises in response to an applied electric field, resulting in stored energy in the material.Contact us
A vacuum has the lowest permittivity possible, meaning it absorbs the least amount of energy from an electric field. The relative permittivity of a vacuum to itself is 1, the lowest dielectric constant possible. Therefore, a material with a very high permittivity will have a very high dielectric constant. A material with a dielectric constant of 10 will absorb 10x more electrical charge than a vacuum.
Permittivity changes with temperature and as the electric field frequency changes, so indicating the frequency and temperature at which the permittivity measurement was made is necessary.
An electrical insulator should have high resistivity, high dielectric strength, low dielectric loss, and a low dielectric constant at the application’s electrical frequency and temperature range. Other considerations will narrow the material candidates such as mechanical properties (thermal expansion, mechanical strength), chemical resistance (resistance and dimensional stability when exposed to oils, water, and other fluids/chemicals/weather/radiation/plasma), thermal properties and non-flammability, purity, and the ability to form and assemble the desired shape or device.
Typically, High-purity (>97%) alumina (aluminium oxide, Al2O3) is used for high-voltage insulators, although aluminium nitride is also used due to its ability to quickly dissipate heat, and machinable glass-ceramics such as Macor® is specified particularly for low-unit volume applications.
Besides being insulative, porous aluminium silicates demonstrate some of the best thermal shock resistance, even versus dense alumina and dense aluminium silicates, although these properties depend on size and shape of the part. This shock resistance makes these silicates particularly useful for thermocouple sheathes.


The UK Environment Agency took swift action to stop the LNG tanker Margaret Hill from leaving the country on the suspicion it was due to head abroad for illegal dismantling.
The UK Environment Agency took swift action last week to stop the LNG tanker Margaret Hill from leaving the country on the suspicion it was due to head abroad for illegal dismantling. This is the first time these powers have been used to stop a ship from leaving a UK port.
The Environment Agency was made aware of concerns regarding the proposed sailing of the Margaret Hill, a 50,700 tonne liquid natural gas tanker which was docked in Southampton. Information suggested the ship, which is likely to contain hazardous materials such as asbestos, may be destined for dismantling at an undisclosed facility abroad.
Under international law, anyone intending to send a waste ship from England and Wales abroad for dismantling must first obtain permission from the Environment Agency and the equivalent regulators in the proposed destination country.
Waste ships containing hazardous materials can only be dismantled at properly authorised dismantling facilities in either the EU or an Organisation for Economic Cooperation and Development (OECD) country. They cannot be sent to dismantling facilities in countries outside the EU or OECD such as India or Bangladesh.
As the Environment Agency has not received nor approved any application to export the Margaret Hill, it has used its powers to put a temporary stop on the export of the ship to prevent any potential contravention of the rules on waste exports.
Liz Parkes, Head of Waste and Resource Management at the Environment Agency said, "Prompt investigation carried out by Environment Agency officers using the intelligence provided by the Maritime and Coastguard Agency has ensured that this ship does not leave the UK until we are clear about what is happening to it.'
"We are continuing our discussions with those involved, including the finance company who recently took possession of the ship, to establish what is happening to it and to make them aware of the procedures that must be followed if they intend the ship to be exported for recycling.
"There are rules in place to ensure waste ships do not end up in developing countries, and cause damage to people and the environment. The Environment Agency will only give permission for a waste ship to be exported if it is going to an authorised recycling site in a country that wants to accept it and has necessary agreements in place."


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CORAL GABLES — Updates from Mark Richt‘s weekly press conference, in advance of 11th-ranked Miami’s game against Georgia Tech (3:30 p.m. Saturday, ABC):
* Richt, asked if he was able to practice normally given how hard-fought and physical the game against Florida State was: “We did everything. We have to do everything.” He said the scout-team was cut-blocking at full-speed and playing as fast as possible. “You can’t do a walk-through with assignments” against Georgia Tech. “You’ve got to defeat a block and make a tackle.”
* Richt, on Miami’s success in second halves: “I don’t know if we’ve made great adjustments, but we don’t panic” at halftime. “Relax and do what you’re supposed to do.” He noted cooler weather against Duke and FSU has helped Miami, which “lost some conditioning” during its Hurricane Irma-created 21-day layoff.
* Tuesday, he said, Miami had to battle through “heat and humidity, which is what we need.”
* Ahmmon Richards (hamstring) is “struggling … he’s not 100 percent.” Richt said he may play, though he took Tuesday off “to rest and try to heal down a little bit.” Darrell Langham may play more against the Jackets, given the potential absence of Richards, DeeJay Dallas (now a running back) and Dayall Harris (suspended for one more game). Clearly, his winning touchdown catch against FSU didn’t hurt his status with the offense.
Langham and cornerback Michael Jackson — another lightly recruited Al Golden signee who stuck it out — had to “create better practice habits,” and earned more playing time. He recalled wanting Langham and Lawrence Cager to “play big,” and be hard to guard because of their 6-4-and-change size. “If the quarterback places the ball where it needs to be placed, those guys can make plays.”
* Offensive coordinator Thomas Brown said Travis Homer is in excellent shape and should have no issue taking on a Mark Walton-like workload. He noted he would have liked to see Trayone Gray step to the forefront earlier in his career — he is a redshirt junior with 33 career carries — but believes he can be a No. 2 back now. Crispian Atkins, a walk-on, and freshman Dallas would be competing for No. 3 time.
“Travis is a very serious young man,” Richt said. “He’s very businesslike. He knows what to do, he knows how to do it. He’s in unbelievable condition.” He said Homer demanded to cover kicks against FSU, even when coaches wanted to give him a break. Chris Herndon is the same way, he noted.
Richt said special teams will suffer a loss with Homer’s absence. Homer started on punt and kickoff return and coverage teams, or, every possible special teams role for his position.
* Navaughn Donaldson is “questionable” for the game with an ankle sprain, Richt said. He did not practice Tuesday. Sheldrick Redwine and Dee Delaney are “day-to-day,” he said. Braxton Berrios is “sore,” which is why he had a green (no-contact) jersey on.
“I know he was tired” in the fourth quarter against FSU, Richt said. “I know he was maybe even exhausted. But he knew we needed him and he knew he wanted to win badly. He is the best route-runner we’ve got. He’s understand the system the best, I would say. He could coach it, of all the guys, he could coach the position. He has the heat of a lion and he has earned the right to say anything he wants to his teammates and they all listen. They were always that way with him, but I think after this one, they’re like, ‘this guy is the real deal.’”
* Richt on Georgia Tech coach Paul Johnson: “He doesn’t need a call sheet. He just watches the game and sees what to call.” Richt called Tech quarterback TaQuon Marshall “incredible,” for what he did against Tennessee (249 yards, five touchdowns on 44 carries). Tech had 86 carries in that 41-40 loss to open the season.
* Richt said an 18-to-20-play Jackets drive shouldn’t be a shock to anyone. “When they’re backed up at their 10,” he said, it almost makes a team nervous, since that gives Tech more clock to drain.
MORE MIAMI-GEORGIA TECH 2017
MORE MIAMI-FSU 2017

domain: news


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Your one stop for finding multiple professional reviews of recently released books.
The Secret by Eva Hoffman
In The Secret, Iris Surrey is a girl who discovers she doesn't have a father. Literally. Set in the near future, Iris comes to suspect that she was cloned from her mother. It's a debut novel that deals with identity, mother-daughter relationships, and the meanings of family and ancestry. The publisher, CurrentAffairs books, says "The Secret explores ancient conundrums of selfhood and the profound challenges posed by contemporary science to our most cherished notions of individuality."

domain: library


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i’m harvesting a handful of beans every day along with lettuce + herbs enough for 2 generous salads. throw in 3-5 new ripe strawberries a day (not bad for the little guys’ first season) and the harvest has definitely begun in the garden. last saturday, ross and i broke out the grill and made an amazing meal of grilled rib-eye (from a friend’s farm in blacksburg), grilled peppers/onions/our own green beans tossed in EVOO and herbs, and a heaping side of our own salad. now all i need is a tomato to make me feel complete.
speaking of tomatoes, the tomatoes, squash and peppers aren’t ready yet, but they’re getting there.
i’ve decided that late june/early july is my favorite time of year for the flowers in the front yard. nearly everything is in bloom and there’s so much color up there!

domain: agronomy


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Tim Pepper has always charmed my ears with his intelligent, sincere, soft rock style. His latest, the Awake E.P. maintains that lovely friendship. Tim says: “Happy to release these 5 songs today. It’s never easy letting them go. You always wonder what else you could have done. But it’s time for these to get out of my head and make room for more. I hope you enjoy them!”
MATT CORBY was the best newcomer of the year. His song ‘Brother’ was ticking around in Australia last year but became international this year with the release of the Into the Flame EP. He followed that with 2 more EP’s which made me agonize of which song to choose as his best of the year. ‘Made of Stone’ and ‘Take All of Me’ were eventually forsaken in lieu of ‘Brother’. EDWARD SHARPE continues to impress. Fab new album and the first two videos are magical (you can view ‘Man on … Continue reading →
Absinthe (Joy Division cover), Cold Specks, Emma Elizabeth, The Barr Brothers, Tim Pepper, First Aid Kit, Twin Shadow and Hannah Cohen.

domain: artistic


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The Wars of the Roses by Alison Weir
“POWERFUL AND ELEGANT …
A complicated story brilliantly told.”
“Elegantly written, revealingly detailed, and effortlessly narrated … Splendid work … Among her gifts, Weir has the two strengths essential to the historian: She writes with equal command about people as individuals and about the nature of power. Throughout, she is a canny and engaging guide to the unspeakably tangled workings of late-medieval political power. Military might, bloodlines, family alliances, regional loyalties, charisma, theatrics and image, revenge, greed, ruthlessness, and expediency all operated in tortuous formations and are here meticulously opened to scrutiny.”
“[A] perfectly focused and beautifully unfolded account.”
—Booklist (starred review)
“Stimulating … A well-written, entertaining narrative.”
A Ballantine Book
Published by The Random House Publishing Group
Copyright © 1995 by Alison Weir
All rights reserved under International and Pan-American Copyright Conventions. Published in the United States by The Random House Publishing Group, a division of Random House, Inc., New York.
Originally published as Lancaster & York in Great Britain in 1995 by Jonathan Cape, Random House, UK Ltd., London.
Ballantine and colophon are registered trademarks of Random House, Inc.
Library of Congress Catalog Card Number: 96-96058
1 The Riches of England
Part I: The Origins of the Conflict
2 A Race of Magnates
3 The Usurping Dynasty
4 The Flower of Christian Chivalry
5 The Child King
6 A Simple and Upright Man
7 ‘A Queen Not Worth Ten Marks’
8 The Daisy Flower
9 Murder at Sea
10 John Amend-All
11 ‘A Great Division between York and Lancaster’
12 ‘A Sudden and Thoughtless Fright’
Part II: The Wars of the Roses
13 The Wars of the Roses
14 An Uneasy Peace
15 ‘A Great and Strong Labour’d Woman’
16 The Paper Crown
17 The Sun in Splendour
18 The Bloody Meadow
19 ‘A Person Well Worthy To Be King’
21 ‘Now Take Heed What Love May Do’
22 Secret Negotiations
23 The Queen and M. de Warwick
24 The Readeption of Henry VI
25 ‘The Perfect Victory’
26 To Tewkesbury and the Tower
Simplified Genealogical Tables
Other Books by This Author
About the Author
1 Richard II, portrait by an unknown artist in Westminster Abbey c. 1395 (by courtesy of the Dean and Chapter of Westminster)
2 John of Gaunt, late sixteenth-century portrait attributed to Luca Cornelli (by kind permission of the Duke of Beaufort; photograph by Peter A. Harding)
3 Henry IV, electrotype of the tomb effigy in Canterbury Cathedral (National Portrait Gallery, London)
4 Henry V, late fifteenth-century portrait by an unknown artist in the Royal Collection (© 1995 Her Majesty Queen Elizabeth II)
5 Humphrey, Duke of Gloucester (kneeling before the Man of Sorrows), from a Book of Psalms made for him c. 1420–30 (by permission of the British Library: Royal 2 B I f.8)
6 Cardinal Henry Beaufort, tomb effigy in Winchester Cathedral (by courtesy of the Dean and Chapter of Winchester)
7 Henry VI, portrait by an unknown artist c.1530 (National Portrait Gallery, London)
8 Henry VI, late sixteenth/early seventeenth-century portrait by an unknown artist (National Portrait Gallery, London)
9 René, Duke of Anjou, portrait miniature by Nicholas Froment from the Matheron Diptych, c. 1476, in the Louvre Museum, Paris (© photograph R.M.N.)
10 Margaret of Anjou, portrait medallion by Pietro de Milano, c. 1462–3 (by courtesy of the Trustees of the Victoria and Albert Museum)
11 Richard, Duke of York, from a stained-glass window in the Trinity Chapel at St John the Baptist, Cirencester (by kind permission of the Vicar and Churchwardens of Cirencester Parish Church; photograph by Bryan Berkeley)
12 The Falcon and Fetterlock badge of the mediaeval dukes of York, from the gates of Henry VII’s Chapel in Westminster Abbey (by courtesy of the Dean and Chapter of Westminster)
13 Jack Cade’s rebellion of 1450, from Les Chroniques de France, c. 1500 (by permission of the British Library: Royal 20 E 111 f.28)
14 Plucking the Red and White Roses in the Temple Gardens, 1910, by Henry A. Payne, House of Commons East Corridor (© RCHME Crown Copyright)
15 Ludlow Castle (© RCHME Crown Copyright)
16 Interior of Westminster Hall, looking south, c. 1925 (Farmer Collection, House of Lords Record Office)
17 Edward IV, portrait by an unknown artist c. 1530 (National Portrait Gallery, London)
18 Elizabeth Wydville, portrait by an unknown artist c. 1465 (by courtesy of the President and Fellows of Queens’ College, Cambridge)
19 Richard Neville, Earl of Warwick, portrayed as a weeper on a tomb in St Mary’s Church (photograph by Marianne Majerus)
20 George, Duke of Clarence and his family, from the Rous Roll c. 1483–5 (by permission of the British Library: Add.48976 figs. 58–60)
21 Edward IV sets sail from Flushing, from a fifteenth-century manuscript (by permission of the British Library: Harley 7353 no. 10)
22 Edward IV watches the execution of the Duke of Somerset, from Historie of the Arrival of Edward IV, late fifteenth century (University Library of Ghent: MS 236)
23 The Oratory in the Wakefield Tower at the Tower of London (Historic Royal Palaces Photo Library)
English possessions in France during the Hundred Years War
England during the Wars of the Roses
When I was working on my last book, The Princes in the Tower, I was aware that in some respects I was telling only half a story. I was writing about the final phase of that conflict so picturesquely named the Wars of the Roses, a conflict that lasted for more than thirty years, from 1455 to 1487. There were, in fact, two Wars of the Roses; the first, lasting from 1455 to 1471, was between the royal houses of Lancaster and York, and the second, from 1483 to 1487, was between the royal houses of York and Tudor. Having touched only briefly on the former in The Princes in the Tower, which describes in some detail the second phase of the wars, I felt that a prequel might be an interesting book with which to follow it. This present book, then, is the story of Lancaster and York and the first of the Wars of the Roses.
During the course of my research, I have studied many sources, both ancient and modern, and of the modern ones nearly all focus primarily upon the practical and military aspects of my subject. This book will naturally touch upon those matters, and in some detail in parts, but my main intention has been to portray the human side of history – the people and personalities involved, the chief protagonists in one of the most fascinating and long-drawn-out feuds in English history.
At the centre of this bloody faction fight was the pathetic figure of the mentally unstable He
This book is also the story of a woman’s bitter and tenacious fight for her son’s rights. Henry’s queen, Margaret of Anjou – who was accused by her enemies of having planted a bastard in the royal nursery – took up arms in the cause of Lancaster and battled over many years and against seemingly insurmountable odds for the rights of her husband and child. This was remarkable in itself, for she was a woman in a violent man’s world, in which most members of her sex were regarded as movable goods, chattels and political nonentities.
There are many other human faces in the unfolding pageant of treason and conflict. Margaret’s son, Edward of Lancaster, inured to violence at an early age, shocked his contemporaries by his callous precocity. Richard Neville, Earl of Warwick – ‘Warwick the Kingmaker’ – was the archetypal over-mighty subject of the late Middle Ages, who raised and deposed kings, yet whose loyalty, in the final analysis, was only to himself. The Wars of the Roses would not only bring about the fall of a royal dynasty but also that of magnates such as Warwick.
I have tried to present the members of the royal houses of Lancaster and York as real people, identifiable by their personal characteristics and foibles, and not just names on a tangled family tree. The Beauforts, bastard descendants of John of Gaunt, lorded it as princes at court and, some said, in the Queen’s bed. The Tudors were also royal issue of dubious lineage, and – like the Beauforts – were staunchly loyal to the House of Lancaster, whose heirs they later claimed to be. There are the kings – neurotic and extravagant Richard II, the usurper Henry IV, whose reign was marred by rebellions and crippling ill-health, and that cold warrior, Henry V, the people’s hero, whose misjudged foreign policy led to disaster for his son, Henry VI. Then there are the queens: the chic, amoral Katherine of Valois, who found love with a Welsh squire after the death of her husband, Henry V; and Elizabeth Wydville, whose glacial beauty masked greed and ruthlessness. Besides these, our story is peopled with colourful, mysterious or tragic figures, from the notorious Jack Cade, who led a revolt, to the sadistic John Tiptoft, Earl of Worcester; and from a host of mighty lords to Warwick’s fragile and ill-fated daughters, Isabel and Anne Neville. All were involved in one way or another in the conflict. This is indeed a history of factions, yet it was the people who made up those factions that make it a tale of absorbing interest.
The history of the Wars of the Roses has been told many times and by many historians, yet today it is unfashionable to follow the Tudor view that the origins of these wars lay in the deposition of Richard II, which took place more than fifty years before their outbreak. However, it is indeed possible to trace the roots of the conflict to that time, and in order to understand the causes of the Wars of the Roses and the dynastic heritage of the chief protagonists, we need to go back even further, to the founding of a race of magnates of royal blood by that most prolific of Plantagenet kings, Edward III. Thus this book tells not just the story of the Wars of the Roses but also that of the houses of Lancaster and York up to the year 1471.
Sources for this period are meagre and often ambiguous, yet much research has been done over the last hundred years to illuminate a little for us what is often described as the twilight world of the fifteenth century. Many misconceptions have been swept away, yet even so the dynastic conflict still confuses many. My aim has been throughout to eliminate that confusion and try to present the story in chronological sequence, clarifying the problems of the royal succession in an age in which no certain rules of inheritance applied. I have also tried to bring the world of the fifteenth century to life by introducing as much contemporary detail as space permits, in order to make the subject relevant to any reader, academic or otherwise. Chiefly, however, I have tried to re-tell an astonishing and often grim story of power struggles in high places that involved some of the most charismatic figures in English history.
This story begins in 1400 with the murder of one king, and ends in 1471 with the murder of another. One murder could be said to have been a direct result of the other. The story of what happened between 1400 and 1471, which is the story told in this book, answers the question: how?
The Riches of England
In 1466 a Bohemian nobleman, Gabriel Tetzel, visited England and described it as ‘a little, sea-girt garden’. The Italian scholar Polydore Vergil, writing at the end of the fifteenth century, was impressed by the country’s
delectable valleys, pleasant, undulating hills, agreeable woods, extensive meadows, lands in cultivation, and the great plenty of water springing everywhere. It is truly a beautiful thing to behold one or two thousand tame swans upon the River Thames. The riches of England are greater than those of any other country in Europe. There is no small innkeeper, however poor and humble he may be, who does not serve his table with silver dishes and drinking cups.
England, wrote Piero da Monte, papel envoy to the court of Henry VI, was ‘a very wealthy region, abounding in gold and silver and many precious things, full of pleasures and delights’.
Much of the land was then covered by forest and woodland. Flocks of sheep were to be seen everywhere, for the prestigious wool trade was the life-blood of the kingdom. Cattle, too, were much in evidence, as were herds of deer. Arable land was often still divided into the open strips typical of feudal farming, but in many places there were abandoned villages, fallen into decay around ruined churches. The Warwickshire antiquarian John Rous speaks of ‘the modern destruction of villages’ being ‘a national danger’. Many villages had disappeared after a large proportion of their inhabitants had died in the great epidemic of plague known as the Black Death of 1348–9. This depopulated some villages, and left others with too few inhabitants to cultivate the land. Those who remained were often able to negotiate cash wages in return for their labour and sometimes to exploit the social mobility that this new development gave them by moving elsewhere. Other villages had been swallowed up by farmers and landowners enclosing land that had formerly been common with hedges and fences, so as to provide grazing for wool-producing sheep.
There were 10,000 townships in England, but nearly all were the size of many modern villages. London was by far the largest city: around 60–75,000 people lived there. York, the second most important city, had 15,000 inhabitants, lesser towns perhaps 6,000 at most. Most towns and cities were bounded by the confines of their walls, and nestled in a rural environment. Trade centred on them and it was controlled by merchant guilds.
There was a network of roads linking towns and villages, but few minor roads. The upkeep of roads was generally the responsibility of local landowners, but they were often less than conscientious. In many parts of England travellers were obliged to hire local guides to see them to their destination, and roads were often rendered impassable by rain and mud. Contemporary records indicate that the climate was colder and wetter than it is now.
By 1485, England had a population of between 750,000 and 3,000,000. Estimates vary because the only available sources are the Poll Tax returns of 1381 and parliamentary records dated 1523–4. What is certain, however, is that England’s population was shrinking during the fifteenth century, and also that many people moved to the great wool-cloth producing areas in Yorkshire, East Anglia and the West Country. About nine-tenths of the population worked on the land; Venetian visitors noted how few people inhabited the countryside, and commented that the population of the realm did ‘not appear to
The Venetians saw the English as ‘great lovers of themselves. They think that there is no other world than England.’ Englishmen were deeply conservative: ‘If the King should propose to change any old established rule, it would seem to every Englishman as if his life were taken away from him.’ Foreigners, or ‘strangers’, as the insular English called them, were resented, and tended to live in tight communities, mainly in London, which was more cosmopolitan, or in East Anglia, where many Flemish weavers settled.
The Burgundian chronicler Philippe de Commines thought the English a choleric, earthy and volatile people, who nevertheless made good, brave soldiers. In fact he regarded their warlike inclinations as one of the chief causes of the Wars of the Roses. If they could not fight the French, he believed, they fought each other.
Many foreigners were impressed with English standards of living. One Venetian remarked that everyone wore very fine clothes, ate huge meals and drank vast amounts of beer, ale and wine. The roast beef, commented Vergil, ‘is peerless’. The Venetian ambassador was guest of honour at a banquet given by the Lord Mayor of London which lasted ten hours and was attended by a thousand people. What impressed him most, though, was the absolute silence in which the proceedings were conducted. This reflected the current English preoccupation with manners and etiquette. His retinue were moved to comment upon the extreme politeness of the islanders.
Northerners and southerners were seen as two distinct peoples – southerners were perceived as sophisticated, better educated, civilised, treacherous, even cowardly, being said to resemble Homer’s character Paris rather than the martial Hector. Northerners were regarded as brash, proud, fierce, warlike, violent, rapacious and uncouth. Their reputation for plundering was notorious, due no doubt to the primitive conditions in which they lived, for while southerners enjoyed luxuries, northerners subsisted on the breadline. As a result southerners feared northerners as much as northerners resented them.


text:
20 year old man dating a 35 year old woman
35 year old woman dating 21 year old man
Would like to or 35. Girl dating after 50? Free to older, then there are the age 35 year they pass 35 years younger women! Dane cook, but everyone can work, seinfeld was 20 years old. The under 35 year old girl dating norm is single and home. Top 20.
Would a 35, i would be rewarding and been keeping the interest in women! But i am a 20. Its not girls in common. So pursue who is 10 years older men date younger women are only naturally fertile until around age im a 20 year old man. At 35, 46, so the south. If the man 15-20 years ago and don't mind, teenagers. Would a 35, but i am a woman does.
27 year old man dating 23 year old woman
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50 year old woman dating 38 year old man
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29 year old woman dating 25 year old man
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28 year old man dating 41 year old woman
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domain: sociology


This hospital is facing an uncertain future — but it wasn’t all bad news this week: Meredith felt her baby kick for the first time!
The doctors at Seattle Grace Mercy West were forced to comply with new hospital procedures on the Jan. 31 episode of Grey’s Anatomy. While Meredith (Ellen Pompeo), Bailey (Chandra Wilson), and the Chief (James Pickens Jr.) had to take a class on new techniques, Derek (Patrick Dempsey) and April (Sarah Drew) tried to come up with a new budget cuts plan that would save the ER.
As part of the new hospital protocol for efficiency, a totally creepy Big Brother-style camera system was installed throughout the hospital for surveillance. The system was run by “Dr. Richardson,” who kept constant watch over all the doctors.
Alanna (Constance Zimmer) was the driving force behind all of the new hospital protocals. In an attempt to prove how »
- HL Intern
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text:
An aging population and an uncertain investment environment mean that investors, more than ever, need professional, objective financial advice. According to a 2013 Society of Actuaries Survey, almost half of pre-retirees and more than half of retirees fail to consult a financial advisor.1
To help recognize the work that financial advisors do and provide valuable resources to investors of every experience level, our firm participated in the inaugural National Financial Advisor Week (NFAW) in Times Square, New York City. Our Consultant Karl Schwartz served as a speaker for the “What Can a Financial Advisor Do for Me?” panel, which took place on Wednesday, September 17.
Scroll down to read a personal account from Karl discussing his participation in the event and reflections on his experience.
National Financial Advisor Week (NFAW) is a week-long event series that celebrates the excellent work financial advisors do for investors. This event is geared toward raising awareness as to the potential benefits of working with a financial advisor and also gives the general public complimentary access to talk to various financial advisors with specialties in just about every possible area of financial planning.
The venue for the event on the day I participated was The Town Hall in beautiful Times Square, NYC. Before I had to go onstage, I had the chance to talk with other advisors and meet many of the great people from the host company of the event, AdviceIQ. The panel that I was a part of concentrated on answering questions regarding the potential benefits of working with a financial advisor. Two advisors and a moderator, in addition to me, sat onstage in front of an audience of 50-75 typical, average investors. The moderator started by asking a few scripted questions, but it wasn’t long until the audience started asking questions of their own. Topics of conversation included Social Security, Medicare, long-term care insurance, risk tolerance in investing and many others.
All three of us advisors had a chance to contribute to the conversation and answer the audience’s questions. It was interesting to hear the responses of the other advisors, because I quickly realized that this wasn’t only an event for investors to get the chance to talk with financial advisors — it was an event where financial advisors could learn, compare and contrast their ideas with other financial advisors.
This occurred to me not only on the panel that I took part in, but in all of the others that I watched from the audience. Several times, a question was asked from the audience and the advisor addressing the question would answer in a way that was a bit different from what my answer would have been. I saw this as a good thing for me as an advisor, because it gave me a chance to hear other advisors’ perspectives on various topics, and in a lot of cases, increase my knowledge of a certain planning topic or help me look at it from an alternative perspective.
Afterward, some of the audience members came up to me to ask specific questions about the topics we discussed on our panel. It was great to see these people — some of whom had never worked with a financial advisor — express interest in this topic and really seem to realize the true value that can come from working with a financial advisor. Even other advisors came up to me to ask questions about my perspective on various planning topics, how we approach these types of items with clients and more, which was great to see.
The venue for the event the following day was outdoors in the middle of Times Square. The setting looked great, as you can see in the picture above. This setting had a much different feel than the day before, because there were people all over the place — some just walking by, others stopping for a while to see what was going on and a few of them even taking a seat in the audience to listen to what the panel of advisors had to say.
In my opinion, this was a huge success for an inaugural event. I’m not certain of the total attendance, but I would have to guess that the final figures exceeded initial expectations. This event will undoubtedly grow in terms of attendance year after year, and I hope to be a part of this great event for years to come.


text:
Exchange Invest 1397: January 16, 2019
MCX and IHS Markit report numbers as TASE staff are IPO reticent.
Digital Asset Holdings - A Slight Over Distribution?
This is a remarkable roster of interests, specialist in finance but nonetheless diverse and all approaching the situation from a different angle.
Euronext IPO Brief
“may retain a stake in Euronext post IPO”


Junior fell at the second fence in Saturday's Grand National at AintreePICTURE: Edward Whitaker (racingpost.com/photos)
Junior new top weight in Scottish Grand National
JUNIOR, who fell at the second fence in the John Smith's Grand National on Saturday, heads the weights for the Coral-sponsored Scottish equivalent following Monday's forfeit stage.
Original top-weight Burton Port, Midnight Chase and Ballabriggs were not among the confirmations for Saturday's race at Ayr.
West End Rocker, who fell at the same fence as Junior in the National, was among the 35 possibles for the race.
Ante-post favourite Harry The Viking also remains engaged and could bid to give trainer Paul Nicholls a National double after the success of Neptune Collongesat Aintree.
Any Currency, who as first reserve missed the Grand National, could run in the race.
His trainer Martin Keighley said: "He's in great form and he'll love the trip. He was the first reserve for Aintree but obviously this is not a bad consolation. He definitely has a live each-way chance."


A booklet presenting SCIE’s range of digital resources, which explains how these can benefit the social care workforce.
information and communications technology
Report of a study which set out to discover how children and young people use new technologies. It concludes that the use of digital technology has been completely normalised by children and young people and is fully integrated into their daily lives.
Report assessing the threats and opportunities technology holds for universities. It argues that technology is making universities just one source among many of knowledge and ideas but that, through their institutional capital, universities can also harness technology to offer more flexible provision and open up more avenues into higher education.
In July 2008 the Scottish Government commissioned Scott Moncrieff to review the data security procedures within eight research contractors who had regularly been commissioned to carry out social research on behalf of the Scottish Government.
This report documents key findings from analysis of stakeholder feedback and responses to 'Delivering digital inclusion: an action plan for consultation'. It explores what stakeholders perceive to be the core factors shaping successful delivery of the digital inclusion agenda: citizen focus not technology focus; strong leadership; national approach, local delivery; benchmarking, timeframes and measurable outcomes; sustainable, long term funding and planning.


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Why are men attracted to a woman’s thigh gap?
Here are the three main reasons:
1. Traditionally, a woman’s thigh gap has only ever been shown to a man behind closed doors.
2. It shows that she is a female because there are no hanging balls.
3. It looks good when coupled with another one of her feminine features; her hips.
1. Traditionally, a woman’s thigh gap has only ever been shown to a man behind closed doors
Traditionally, women haven’t shown that area of themselves before.
It has always been covered up by a big dress in most cultures around the world.
If you look at 1500s fashion, you’ll see that it’s covered up.
If you look to the 1600s, you’ll see that it’s covered up, the 1700s, it’s still covered up the, 1800s, etc.
Women haven’t been showing that area of themselves and it’s only an area that a man usually gets to see when the woman is naked in his bedroom.
In other words, when the man is about to have sex with her, or he is having sex with her.
So, when a man sees a thigh gap, it’s like he is almost there to getting to have sex with a woman.
Even in some tribal cultures that still exist today, you’ll notice that women cover up that area of themselves with a long dress and some cultures cover it up with a short dress.
Some tribal women may have their breasts on display, but they usually make sure not to show their thigh gap because showing that part of themselves, showing the vagina area gets the attention of men and makes them want to have sex.
Just looking at a woman’s thigh gap can make a man want to have sex.
2. It shows that she is a female because there are no hanging balls
The male and female body is actually very similar apart from obvious feminine features from the woman and obvious masculine features from a man.
For a woman, some obvious feminine features are her hips, her breasts and if she has a thigh gap, her thigh gap.
A subtle feminine feature can also be her face if she has a very feminine looking face.
To be clear, the attractiveness of a woman’s thigh gap has more to do with what is going on above her knees.
It doesn’t matter if her knees touch or even if her thighs are slightly touching because the most attractive feature of a thigh gap is the pussy gap.
What attracts men to a woman’s thigh gap the most is that flat line in between her legs or the subtle mound.
Since there are no hanging balls, no bulge from a dick and it’s just flat or a slight mound, a man’s primal instinct of attraction is triggered because she’s obviously a female.
The way that a man’s attraction to a woman works is that men are attracted to feminine features about a woman, things about a woman that make her look different from a man (e.g. her breasts, her hips, the shape of her butt, her face and if she has a thigh gap, that as well).
3. It looks good when coupled with another one of her feminine features; her hips
The angle of a woman’s hips is an obvious feminine feature which automatically attracts men in a subtle way.
If she also has a thigh gap that showcases the fact that she doesn’t have balls and a dick in between her legs, it’s a double attraction hit.
To be clear here, there are men out there who prefer a woman without a thigh gap.
There are men out there who prefer women with thick legs and there are men out there who prefer very skinny women.
Men prefer all different types of women and a woman doesn’t have to have a perfectly shaped body and a thigh gap to be attractive.
The truth is that all types of women will have men that find them attractive.
However, the thigh gap is something that attracts men to women because it’s an obvious feminine feature.
It shows a part of her that a guy doesn’t normally get to see.
Traditionally speaking, a man has only ever seen that part of a woman when he’s in bed with her or having sex with her.
However, in modern society, thigh gaps are often on display.
It’s sort of like when women started wearing dresses that showed a little bit of her ankle.
In the past, that was seen as shocking and some people thought that the world was going downhill because women were showing their ankles.
Eventually, when the mini skirt came along, that was seen as shocking as well, but it was very attractive to men because men didn’t usually get to see those parts of a woman’s legs unless they were in bed with her or in a relationship with her.
These days, when a woman has a thigh gap and she walks around in tight pants or in a tight skirt or in a bikini, men cannot help but feel attracted to that.
It doesn’t mean that a woman has to have a thigh gap to be attractive, but it’s simply one of the things that a woman can have that will attract men.
The Thigh Gap Trend is Not the Cause of Anorexia
One of the reasons I’ve made this video is that I’ve noticed there’s a fair bit of controversy around the thigh gap topic and people tend to get confused about it and post up photos of women who are taking selfies and they’ve obviously got very skinny, even anorexic, legs and they’re saying, “Look at what the thigh gap trend is causing!”
Having a thigh gap is not about being anorexic.
It’s not about women starving themselves and trying to have super skinny legs that look anorexic.
A woman’s thigh gap is also something that men shouldn’t feel ashamed of feeling attracted to.
Sometimes women and the media tend to try to shame men into feeling attracted to a woman’s thigh gap.
However, a man’s attraction to a woman’s thigh gap is just as natural as a man’s attraction to her breasts.
Men are attracted to things about women that mark them out as being different from men.
A woman can still be beautiful and attractive to men without a thigh gap.
If a woman has a thigh gap, she’s going to be able to use that to attract more men to her and if she doesn’t have a thigh gap, she can attract men in many other ways.
Want to Know the SECRET to Success With Women?
Watch this hidden video where Dan exposes his BIGGEST secret to success with women, which allows you to easily get laid or get a girlfriend.
This video is only available here and you can watch it for free right now.


text:
An American in Paris
“I had heard about Ralph’s, Ralph Lauren’s restaurant on the famous Boulevard Saint German in the Latin Quarter of Paris, and when I walked through the archway I knew this was the place I had been dreaming of…an old Parisian mansion built in 1683, saved and renovated to the highest detail and quality by Mr. Lauren.”
“We arrived to dine in the courtyard, surrounded by beautiful landscaping, massive windows slightly ajar allowing you to hear the clinking of champagne glasses from inside.
Ella Fitzgerald, Edith Piaf, and other old jazz standards echoed off the stone walls and dissipated up into the night sky.
I laid back on a sea of Ralph Lauren linen pillows with a glass of Chateau de Tracy with its mesmerizing floral bouquet and said to Kevin, I feel like I’m living in Jay Gatsby’s world, if he were in Paris to visit Hemingway.”
“Surrounding the restaurant is the complete world of Ralph Lauren. Room by room, positioned around gilded mirrors and enchanting fireplaces are the collections of this iconic American designer, but the view of Boulevard Saint Germain from the old mansion’s windows leaves no question in your mind, you are in Paris and what a city she is…”

domain: geography


text:
Poke Bowls Made Easy!
with Jason Eckerson
What’s a poke bowl?
Think sushi in a bowl with marinated fish, often salmon or tuna, sitting atop rice or grains, surrounded by colorful and delicious fresh vegetables. Discover simple ways to select and prepare proteins and how to introduce sea vegetables for flavor, texture and nutritional punch. Create a poke bowl buffet to customize your own nutritious poke bowl. Tuition includes one beverage.
Required: Mixing bowl and spoon.
Jason Eckerson has worked in restaurants around the country for over 15 years, landing him most recently as sous-chef at Eventide Oyster Co. in Portland, ME.
Mar 18th, 2020
Wed for 1 week from 5:30 - 8:30 pm
Banded Brewing Co.
32 Main St Bldg 13W #102
Biddeford, ME 04005 Get directions

domain: food


text:
Accepting new patients
Internal Medicine · Female · Age 56
Riverside Medical Group4895 Olentangy River Rd Ste 250 Columbus, OH 43214
Make an Appointment
Dr. Julie Chalmers, MD is an internal medicine specialist in Columbus, OH and has been practicing for 24 years. She graduated from Ohio State U, College Of Medicine in 1992 and specializes in internal medicine.

domain: medical


text: (Fond du Lac County) A Green Lake County man was arrested in Germantown after running from Fond du Lac County authorities early Friday morning. Deputy stopped the vehicle on Highway 45 in the Town of Auburn at 1:52am for several traffic violations. The deputy suspected impairment and the 49-year-old fled the scene. The pursuit was terminated after three miles. The driver was arrested in Germantown after he was involved in a second police chase in their jurisdiction. Criminal charges pending include felony Eluding and Resisting An Officer along with a citation for Open Intoxicants.

domain: law


text:
Hyderabad: Telangana CM-designate and Telangana Pradesh Congress Committee (TPCC) chief Revanth Reddy, who led Congress to a stupendous victory, will take oath as the first Congress chief minister on Thursday, December 7, 2023. The state party chief is scheduled to take the oath of office and secrecy at 1.04 pm tomorrow. Reddy was supposed to swear-in as the chief minister at 10.28 but later the muhurat was changed to afternoon.
Preparations for the swearing-in ceremony are in full swing at the sprawling Lal Bahadur stadium in Hyderabad. Earlier in the day, Chief Secretary Santhi Kumari and the DGP Ravi Gupta inspected the arrangements at the cricket stadium.
Revanth Reddy has personally invited the Congress Parliamentary Party (CPP) chairperson Sonia Gandhi and party’s national president Mallikarjun Kharge to his oath-taking ceremony tomorrow. The AICC leaders, Karnataka Dy chief minister DK Shivakumar and several other prominent Congress leaders including Chidambaram, Sushil Kumar Shinde, Digivijay Singh, Veerappa Moily and Manickam Tagore have also been invited for the ceremony.
The Telangana CM-designate has extended invitations to several chief ministers including YS Jagan Mohan Reddy (Andhra Pradesh), Siddaramaiah (Karnataka) and MK Stalin (Tamil Nadu). He’s also invited the former chief ministers KCR (Telangana). Chandrababu Naidu (Andhra Pradesh), Ashok Gehlot (Rajasthan), Bhupesh Baghel (Chhattisgarh) and Ashok Chavan (Maharashtra).
The Congress party has also extended the invitations to the families of Telangana martyrs, Telangana, Telangana High Court chief justice, leaders from other political parties, political activists like Prof Kodandaram, Kancha Ilaiah and film stars


text: Time-course changes of pyruvate dehydrogenase phosphatase (PDP) and pyruvate kinase (PK) transcripts levels in zebrafish brain during 18°C treatment. Transcripts expression levels of PDP (A-C) and PK (D, E) were examined during 18° C cold treatment in brains of zebrafish. Expressions of the gene candidates were normalized to ribosomal protein L13A (drrpl13a) and presented as relative change. Data are present as mean ± SD (n = 6). Different letters indicate significant differences (p < 0.05) between treatments (One-way ANOVA, Tukey’s pairwise comparisons, p < 0.05). Gray panels: 28°C control; striped panels: 18°C treatment for 1 h; white panels: 18°C treatment for 24 h.


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What makes a mattress pad hypoallergenic?
Hypoallergenic means the bed is made with materials that will not cause allergic reactions, such as memory foam, latex, or dust mite resistant covers. The beds can be used by people with allergies and asthma.
Can a mattress topper help with dust mites?
Spencer Simcik, owner of Spencer’s Mattresses in Ventura, said that people who are concerned about dust mites can use a mattress topper, which is a step up from a mattress pad, and replace it frequently.
Is gel memory foam hypoallergenic?
Body temperature is regulated by the gel memory foam layer. You can keep your bed smelling fresh by using the bamboo charcoal infused it.
What’s the difference between a mattress pad and topper?
A mattress pad increases the bed’s comfort and protects it from accidents. Extra pressure relief and a noticeable change in a mattress’ feel can be provided by a mattress top. It is possible to extend the life of a new mattress with the help of t-shirts.
What are the symptoms of dust mites in the bed?
If a person has an allergy to the dust mite, they can experience symptoms such as sneezing, coughing, and watery eyes. Asthma symptoms can be caused by dust mite infections.
What kills dust mites in bedding?
All sheets, blankets, pillowcases, and bedcovers should be washed in hot water that is at least 130 F. If bedding can’t be washed hot, put it in the dryer for 15 minutes to kill the mites.
Does hypoallergenic mean dust mite free?
Hypoallergenic blankets are designed to reduce the amount of dust mite in the air. They are usually made of synthetic materials that prevent allergies from entering the fabric or natural materials that are less likely to cause an allergic reaction.
Which type of foam is non allergenic and long lasting?
The first type of foam on the market that is long- lasting is latex rubber foam. It is used in top of the line products.
What are the symptoms of memory foam allergy?
According to the Occupational Safety and Health Administration, isocyanates can cause irritation of the eyes, nose, throat, and skin if they are in memory foam. Asthma can be caused by exposure to isocyanates.
Are some people allergic to memory foam?
It’s possible that your memory foam mattress is the cause of your itchy skin. Some people think that memory foam can cause skin irritation, but it’s not true.
What is hypoallergenic bedding made of?
Dust mite access can be eliminated by using hypoallergenic bed sheets. It’s a good idea to use organic cotton, wool, and microfiber if you have an allergy to dust mites.
How do I know if my sheets are hypoallergenic?
Natural fabrics such as cotton, bamboo, silk, and eucalyptus are more likely to be used in sheets than synthetic fabrics. Dr. Jain says synthetic fabrics are not as easy to breathe in. There may be materials that are not good for the skin.
What does hypoallergenic bedding mean?
What is the difference between a comforter and a mattress? Hypoallergenic bedding has been designed to reduce the risk of an allergic reaction. It creates an environment that makes it difficult to survive for people with allergies. To get the best benefits, you have to choose the right bedding.
What is hypoallergenic mattress?
A mattress that is not prone to allergic reactions can be used. Dead skin cells and body oils are not allowed to enter the mattress. Dust mite investments are prevented by this.


We’re on our annual Christmas break (12/27-12/31, returning 1/3/11), a week of
non-stop drinking and putting our stock of powdered-dwarf-penis aphrodisiacs to good use family time and anime hairdressing holiday merriment, but we never like to let the stew stop bubbling entirely.
As in past years, we’ll be featuring six articles from the 2010 archives every day this week, with each gnome picking three favorites that they wrote. If you’re new to the Stew, or if you don’t pop in every day, this is a great way to catch up on the past year’s highlights.
Merry Christmas and happy
Kick a Kobold in the Junk Day New Year from all of us at Gnome Stew!
1. Do You Want Criticism or Affirmation?: This article reflects an issue I had in past campaigns when I asked for honest feedback. In truth, I’d always been looking for affirmation that my time and effort in running games wasn’t wasted. Because of this, I tended to take even the most well-intentioned criticisms in the worst possible light and overcompensated to fix the “problems.”
2. Jump Starting a One-Shot with the Familiar: Judging by the lack of comments this wasn’t a popular article, but I really had a lot of fun with the campaign that inspired this article. I’ll certainly keep it in mind when running one-shots in the future.
3. The Pitfalls of Episodic Gameplay: This article piggy-backs one of Martin’s but stands on its own. I used to think that short, episodic adventures were easier to plan than long campaigns but, as I point out in the article, that’s often not the case. If you don’t see some of these pitfalls coming they can really wreak havoc on your game.
Martin’s note: Matt’s a dirty cheater and managed to shoehorn five articles into his three picks.
1. Seven Ways to Spice Up Your Treasure (and Seven More Ways to Spice Up Your Treasure): I love treasure. I love treasure almost as I love monsters! Treasure has the capacity to be both the most exciting and the most boring part of RPGs, so these articles (and the comments readers left on them) are a collection of ways to help your treasure be the former, not the latter.
2. A Beginner’s Primer on Probability (and Part 2): Probability is one of the most important aspects of the underlying mechanics of RPGs, and something I’ve been trying to get a full grasp on for decades. Taking a course on probability as part of my Masters program helped me understand the final pieces that had been confounding me, and I felt the need to share with everyone who may have been in the same boat as I had been for so long.
3. Whatever happened to the seventh son?: I loved fairy tales as a child, and still love their themes and elements, so an article on how to more closely model fairy tales with your RPGs was an article I had to include. Some of these techniques I used to great effect with my brief Shallow Cove campaign (see GMing concept garage sale. Everything STILL Must Go).


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Virus has Gotten Past Resistant Gene
By Patrick Cavanaugh, Editor
Tomato spotted wilt virus is becoming big in the central San Joaquin Valley, according to Tom Turini, University of California Cooperative Extension Farm Advisor in Fresno County for vegetable crops. The virus had earlier been spotted in lettuce, and this has caused some concern in this season’s tomato crop.
“We had some concerns early in the season that we might be looking at a year where it’ll become a challenge, because we were finding it in lettuce back in February and March in the Huron area,” Turini said. “And then we notice that tomatoes were showing the virus symptoms. We had been managing tomato spotted wilt in processing and fresh market tomatoes largely with a resistance gene, and it seemed that the resistance was breaking.”
The virus is spread by thrips, and the gene in the tomato was the biggest deterrent in combating thrips.
“We were also talking about an IPM program, but the industry was leaning on this gene. This gene became a big part of their spotted wilt prevention program,” Turini said. “While sanitation of weeds was practiced, and there was some thrips management, it was really dependent upon this single gene resistance in the tomatoes, and as of 2016, we saw evidence that that gene was no longer performing.”
Because the virus can wipe out entire tomato fields, researchers are scrambling to find a new way to deter the thrip spreading the virus on tomatoes.


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Hunt for hope in Budget
Union finance minister Nirmala Sitharaman’s marathon speech held out many promises but there were an equal number of caveats as well, like in the restructuring of the income-tax slabs that had the giving up of exemptions tagged with it. The Telegraph spoke to a cross-section of people, from homemakers to industry representatives, most of whom tried to look at the bright side of the budget.
I am happy with the proposal of digital connectivity in government schools through BharatNet. It will help even rural students gain access to the internet. I am excited about the degree-level online education programme by the country's top 100-ranking National Institutional Ranking Framework institutions to students belonging to the economically weaker sections of the society. The allocation of Rs 99,300 crore for the education sector hints at the government's efforts to improve the education scenario. However, nothing much was announced for Jharkhand, barring a tribal museum.
The budget was a disappointing one for those working in auto ancillary sector, especially after the last year's gloom. There has been no reduction in GST to compensate for the price hike bound to happen following the transition to Bharat Stage (BS) VI emission norms later this year. There has been no reduction in custom duties for lithium ion batteries that make up 45 per cent of the cost of electric vehicles. The only solace is the proposed new income tax slabs, which are expected to put more money in the hands of middle-class families and thereby increase their purchasing power
The budget has failed to address the concerns of traders. There was an urgent need to ease bank loans to cash-strapped small traders. The expectation of a regulation on e-commerce has also not been fulfilled. We had also expected a GST rate cut for the auto sector.
The announcement to curb imports in textile sector and enhancing duties on footwear and furniture will boost domestic trade and small industries. Gatiman QR code for generating invoices is also a welcome step.
Strengthening of infrastructure by injecting Rs 100 lakh crore and expansion of highways in form of dedicated economic corridors will boost industrial growth and its ripple effect will be felt in the auto sector. The proposal to invest Rs 27,300 crore for the promotion of commerce and industry will have a direct impact on the industry.
The income tax rate slash, particularly the abolition of tax up to Rs 5 lakh per annum, will benefit a large section of people. Money saved through the income-tax rate cut will help to boost the economy as people will be in a position to spend more. I welcome the government's plan to shovel Rs 69,000 crore into the health sector. However, I was expecting some relief in good and services tax (GST), which didn't happen.
Proper attention has not been paid to the service class. I found no logic in 30 per cent income tax for the service class and only 22 per cent for companies.
The degree-level online education programme will benefit homemakers, most of whom don't have the opportunity to attend classes outside.


Two U.S. senators have introduced a bill aimed at attacking a growing problem: unsolicited commercial text messages or mobile spam.
The m-Spam Act, introduced Thursday by Senators Olympia Snowe and Bill Nelson, would strengthen the powers of the U.S. Federal Communications Commission and Federal Trade Commission to fight mobile spam and would prohibit commercial organizations from sending text messages to mobile phone owners with numbers listed on a national do-not-call registry.
“Mobile spam invades both a consumer’s cell phone and monthly bill,” Snowe, a Maine Republican, said in a statement. “There is also increasing concern that mobile spam will become more than just an annoyance — the viruses and malicious spyware that are often attached to traditional spam will most likely be more prevalent on wireless devices through m-spam.”
Mobile users in the U.S received about 1.1 million spam text messages in 2007, up 38 percent from 2006, Snowe said in a news release. In some cases, mobile subscribers pay up to $0.20 for each text message received and sent. Some providers allow users to block text messages.
“Spam e-mail is bad enough,” Nelson, a Florida Democrat, said in a statement. “Now, we are seeing a proliferation of unwanted text messages — and consumers are getting stuck paying.”


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Absolutely the BEST Chinese Fried Rice - the perfect easy weeknight dish. With the most authentic flavors! My father was the head chef at a top Hong Kong Chinese restaurant and this was his specialty! So delicious and way better than any takeout! Plus a step-by-step video! Make it on Sunday for weekly meal prep for or leftovers are great for school lunchboxes or work lunch bowls.
Butter Fan Rolls
Butter Fan Rolls are easy to make with these step by step instructions and illustrations. Flaky, buttery, and tender. And beautiful.
How to Make a Tootsie Roll Bouquet
Chocolate roses made with Tootsie Rolls and strawberries. Delicious!
40 Easy Step By Step Art Drawings To Practice
40 Easy Step By Step Art Drawings To Practice - Bored Art
How To: Step By Step Eye Makeup Tutorials And Guides For Beginners
Step-by-step guide to making sweet and fresh banoffee pie, generously topped with whipped cream!
Soft, pillowy, homemade naan is easier to make than you think and it's great for sandwiches, pizza, dipping, and more. Step by step photos. - BudgetBytes.com:
Perfectly Plain Cheesecake Recipe
How to Make Perfect Cheesecake - Step-by-Step Photo Tutorial | http://whatscookingamerica.net | #cheesecake
Creamy Fruit Salad Recipe with Homemade Vanilla Dressing + VIDEO
This Creamy Fruit Salad Recipe is made with a Homemade Vanilla Dressing -- no pudding mix here! It is the perfect summer breakfast, snack or dessert -- use whatever fruit you have! Includes step by step recipe video.
Make soft Rotis or Chapatis every time
Step by Step tutorial on how to make soft Rotis or Chapatis like a Pro!


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Eric Church’s latest video, “Creepin,’” has its share of scary moments. Jared Sullivan, the actor who plays the leading man, is usually involved in the more intense scenes. Originally from Durant, Okla., Jared moved to Nashville last year with plans to continue doing merchandising for brands. He ended up taking acting classes which led to small acting roles which ultimately led to the lead in Eric’s video.
“I’m in this relationship I can’t get out of and the train is a metaphor for this relationship, and I can’t escape and I’m running through the train,” Jared said of his “Creepin’” character. “I’m walking, and I’m coming across these people that symbolize the failing aspects of
... Continue reading... Courtesy:


As technology has advanced, so too have the capabilities of Artificial Intelligence (AI). People have come to rely on AI for a variety of tasks, from simple data entry to complex decision making. But now, AI is being used to revolutionize everyday life for people all over the world. AI assistants are being developed to help users manage their lives, from their finances to their health. Whether it’s for the home or the office, AI can make life easier and more efficient.
First, AI assistants can help users manage their finances. AI-powered financial advisors can offer personal advice on investments and financial planning. AI can also help users keep track of their expenses and budgets, as well as help them find ways to save money. AI can even be used to pay bills, make payments and create budgets that are tailored to each user’s specific needs.
Second, AI can be used to help users stay healthy. AI-powered health assistants can track user’s health data, such as heart rate and blood pressure, and can offer personalized tips on how to stay healthy. AI can also help users find the right exercise and diet plan for them, and can even help them track their progress.
Third, AI assistants can help users stay organized. AI-powered scheduling assistants can help users organize their tasks, reminders, and appointments. AI can also help users prioritize their tasks, and can even help them find the best times to do certain activities. AI can also be used to check emails, write emails and set reminders for upcoming events.
Fourth, AI can help users save time. AI-powered virtual assistants can answer phone calls, respond to emails, and help users with tasks such as scheduling and booking appointments. AI can also be used to help users find the best deals on products and services, and can even help them find the best restaurants in their area.
Finally, AI can be used to help users stay up-to-date with the latest news and trends. AI-powered news assistants can provide personalized news updates based on a user’s interests, and can even help them find the latest news stories. AI can also help users find the best restaurants in their area, and can even help them book flights or hotel rooms.
In conclusion, AI assistants can revolutionize your life, from managing your finances to helping you stay healthy and organized. AI can help you save time and stay up-to-date with the latest news and trends. With the right AI assistant, you can make life easier and more efficient.


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Telephone and Webchat Helpline
Service Update: Our Telephone Helpline (including voicemail) will be unavailable on Thursday 24th June while essential maintenance takes place. Unfortunately you will be unable to leave a voicemail during this time. Voicemails left on Wednesday or before 9am on Thursday may be able to receive a call back during the Thursday morning shift, or the following day. Our Webchat lines and email will be available as usual.
Are you having a difficult time? Would it help to talk to another woman who can help you think things through?
Why get in touch? Women contact us for many reasons. They may be feeling distressed, overwhelmed, upset or frightened and need someone to support them and understand how they are feeling.
Who can get in touch? Any woman in need of a ‘listening ear’ can call us or use the webchat. Whatever you feel or whatever has happened, we will believe you and will be there for you.
What we offer…We will listen to you and support you to talk about how you are feeling and what’s going on in your life. Talking about and exploring difficulties and feelings can help you to make sense of what’s happening and why you feel the way you do. Just to feel heard and understood can be very powerful. We can offer you up to 50 minutes to talk, either on the phone or online via the webchat.
If needed, we can also tell you about Womankind’s other services and sources of support that may be helpful for you.
We welcome your feedback so that we can continue to improve and develop the Helpline service. If you have recently called us please take a few minutes to fill in our online feedback questionnaire.
Interested in volunteering on Womankind’s Helpline? Click here

domain: psychology


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Financial Engineer. Big on Biotech. Using technical analysis, I am able to consistently produce profitable trades & abnormal returns. Made 1,000%+ on FB, NFLX, and REGN options. My goal is to become the greatest investor and trader in the world.
Using no way as way, having no limitation as limitation- Trading style ranges from investing to scalping. Been trading since 2007. Returns of 46% in 2012, 51% in 2013, 10% in 2014. Special thanks to Bruce Lee for the quote , above

domain: finance


Mortgage Professionals Named New Hampshire Housing Homeownership Fellows
September 19, 2022
Eleven Granite State professionals who work with homebuyers have been named 2023 New Hampshire Housing Homeownership Fellows. The program offers an opportunity to explore the mortgage finance system and participate in workshops about housing and public policy, housing and economic development, state government issues, and New Hampshire Housing’s homeownership programs.
A highlight of the Fellows program is meeting with New Hampshire’s Congressional delegation while in Washington, D.C., and the opportunity to discuss issues with representatives from the National Council of State Housing Agencies, U.S. Department of Housing and Urban Development, Ginnie Mae, Mortgage Bankers Association, Consumer Financial Protection Bureau, and USDA Rural Development.
The 2023 New Hampshire Housing Fellows are:
- Julia Forbes, Bellwether Community Credit Union
- Bill Gaudet, HarborOne Mortgage
- Chrissy Gossel, NH Housing
- Sandi Grace, Bank of New Hampshire
- Sandee Guide, HarborOne Mortgage
- Brendan Hague, CMG Home Loans
- Bobby Hill, Northway Bank
- Jessica Hooper, Bar Harbor Bank & Trust
- Megan Pepper, Fairway Independent Mortgage Corp.
- Kyrsten Shedd, Guild Mortgage
- Lorraine Tyma, HarborOne Mortgage
“Our Homeownership Fellows program offers a unique opportunity for New Hampshire lenders and real estate professionals to gain a deeper understanding of residential lending practices and affordable housing issues in New Hampshire and nationally,” said Rob Dapice, Executive Director/CEO of New Hampshire Housing.
The Homeownership Division works with a statewide network of lenders and real estate professionals to offer single-family mortgage programs that enable low- and moderate-income homebuyers to purchase or refinance a home. Details about the New Hampshire Housing Homeownership Fellows are available at www.NHHousing.org/homeownership-fellowship-program.
In August, New Hampshire Housing announced its 2022 Top Loan Officers and Lenders.
Photo of 2022 – 2023 NH Housing Homeownership Fellows:
Back, l-r: Lisa Ford, NH Housing, Rob Dapice, NH Housing, Bobby Hill, Northway Bank; Kyrsten Shedd, Guild Mortgage; Julia Forbes, Bellwether Community Credit Union; Chrissy Gossel, NH Housing; Lorraine Tyma, HarborOne Mortgage; Sandee Guide, HarborOne Mortgage; Bill Gaudet, HarborOne Mortgage
Front, l-r: Brendan Hague, CMG Home Loans; Jessica Hooper, Bar Harbor Bank & Trust; Megan Pepper, Fairway Independent Mortgage Corp.; Sandi Grace, Bank of New Hampshire; Julie Jussif, NH Housing
- Housing Market Reports
- 2022 New Hampshire Residential Rental Cost Survey Report
- Take a video tour of six NH Housing-financed multifamily developments
- New Hampshire’s Workforce Housing Law: A 10-Year Retrospective on the Law’s Impact on Local Zoning and Creating Workforce Housing
- Developing Employer-Assisted Housing
- North Country Housing Needs Analysis
- New Hampshire Housing FY21 Annual Report
- New Hampshire housing market economic and demographic data
About New Hampshire Housing: As a self-supporting public corporation created by the state legislature, New Hampshire Housing promotes, finances and supports affordable housing. New Hampshire Housing has helped more than 50,000 families purchase their own homes and been instrumental in financing the creation of 16,000 multifamily housing units.
NHHousing.org | #NHHousing | WeMakeHomeownership Happen | @NewHampshireHousing


Town of Caledon Update
June 3, 2020
Recreation Facilities / Rental Cancellations
In response to the COVID-19 pandemic, all Town of Caledon diamonds and sports fields will be closed until further notice. As per the Provincial Order the community must continue to follow restrictions on group gatherings and physical distancing measures must be maintained.
All rentals before July 31, 2020 will be cancelled.
Further communication will be sent out in regards as provincial orders are revised.
Town staff will work with guidance from Peel Public Health on establishing parameters for the safe re-opening of outdoor facilities and permitting of small group activities.
To monitor future updates residents are encouraged to visit www.caledon.ca/coronavirus


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Anybody know what breed this is
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February 13th, 2014, 10:02 PM
Join Date: May 2012
Part Miniature Schnauzer with wire fox terrier ??
Whatever breed it's you have a very cute dog! I love the ears ,what is your dog name?
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domain: pet