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Bringing a new cactus home is enough to excite any home gardener, but when it begins to die without an apparent reason, it can be a frustrating process. Luckily, there are ways to get to the bottom of your cactus woes and address the issue to get its health back on track.
So why is your cactus dying? Cacti are generally resilient plants, so a dying cactus mainly stems from improper care or harsh environments. The three possible reasons that your cactus is dying include:
- You are overwatering (or underwatering) your cactus.
- Your cactus is not getting its recommended daily sunlight.
- The soil drainage for your cactus is inadequate.
In this article, we’ll be discussing a few reasons why your cactus may be dying, along with providing you with some proper care tips to help you better maintain your cactus plants.
Why Your Cactus May Be Dying
The following three reasons are the most common bad habits that new cactus owners make that result in a dying cactus:
1. You Are Overwatering (or Underwatering) Your Cactus
Cacti are very specific about how much water they receive, and on average, less is more when it comes to watering them. Cactus plants are prone to root rot, a condition that affects plants that are sitting in pooled water or are watered too often. This causes the cactus to rot from the roots, killing the plant slowly (but surely). If you’re watering your cactus daily, or even weekly, this could be the reason why it’s dying.
On the contrary, you could also not be watering your cactus enough. If half a year has gone by before you think of watering your cactus, and it doesn’t have access to rain, that’s probably the issue. Though cacti don’t need as much water as most other plants, they still need some access to water to thrive.
If you’re a “plant and forget” type gardener, be sure that you have planted your cactus in an area that receives rainfall. Leaving the watering up to nature’s natural cycle is usually plenty for a cactus anyway.
2. Your Cactus is not Getting Its Daily Recommended Sunlight
- drooping or shriveled stems
- scraggly hairs
- dull coloring
- little to no flowering or fruiting during the season
Likewise, placing your cactus in an area that receives too much sun at high temperatures can result in:
- blackened or browned ends of the stems
- a dried or dull appearance
3. The Soil Drainage for Your Cactus is Inadequate
Though it’s essential to water your cactus whenever it needs it, it’s just as crucial to ensure that your cactus is planted in a soil that drains well. A cactus should never be left to sit in water and requires a preferably sandy or slightly gravelly soil. If you have your cactus planted in a pot without a drainage hole or in soil that absorbs too much water, this may be what’s killing your plant.
Another problem to consider is the fertility of your cactus’ soil. Even if you have it planted in cactus-perfect dirt, it could be lacking the nutrients it needs to stay healthy and green. To combat any lack of nutrients in the soil, you should fertilize your cacti, though infrequently.
Additional Reasons for a Dying Cactus
You may be watering your cacti only when necessary, giving it adequate sunlight and proper soil and yet still have an issue with dying cacti. Here are a few additional reasons for a dying cactus that may have slipped your mind:
- You’re not covering it in the winter. Some cacti don’t tolerate winter conditions and temperatures as well as other species and will need to be covered in burlap or in a flower house to prevent frostbite.
- You’re watering your cactus in the winter. Cacti should not be watered in the winter, as this could result in them freezing internally. During the warmer months, cacti will store the necessary amounts of water needed to last through their dormant season.
Though there are cacti that can survive frigid temperatures, your average garden cactus likely will not (or will receive some damage in the process). Covering them and refraining from watering them whenever the temperature drops will help them to endure the colder months better.
How to Properly Care for a Cactus
Now that you’ve found out the possible culprits behind your dying cactus, it’s time to take a look at how to care for your plant to keep it looking its best.
Cacti are incredibly hardy plants and will store water in their cells to prepare for drought or their dormant season (the winter). In most areas throughout the United States, rainfall is enough to keep an outdoor cactus adequately moist and healthy.
However, if you’re experiencing a particularly rough drought or your cactus is indoors, it’s recommended that you water your cactus once a month. If the soil still looks moist when the next watering cycle comes around, wait another week before watering.
Watering in the winter is something that shouldn’t be done unless you’re in an area where winters don’t drop below the mid-60s degrees Fahrenheit. If your winters are practically none, you should still water your cactus less than you would during the warmer months — only about once or twice during the winter, depending on the temperatures.
How to Water Cacti
Though there are a few jungle varieties of cacti, in general, cacti are desert plants. Rather than receiving their water from spritzes of humidity or constant rainfall, a cactus’s roots deeply penetrate the soil to reach the remaining water from the last rainfall and stores as much as possible until the next rain shower.
Because cacti aren’t native to areas with high humidity, watering your cactus with a fine mist or by pouring water directly on its stem will dull the appearance of your cacti, and eventually, lead to surface rot. Instead, you should either apply water directly to the soil (taking care not to water the base of the plant directly) or set your potted cactus in a saucer of water so that its roots can reach and water themselves. Be sure to take the cactus out of the saucer once the soil is dampened.
When watering the soil directly, you should use a slow-moving stream, such as a garden hose turned on low, and water deep enough so that it begins draining from the pot.
Though the amount, and type, of sunlight a cactus needs varies from species to species, most cacti will need about 4 to 6 hours of sunlight per day. Remember to check the light requirements for your particular plant, as some species will need full sun, part sun, or minimal sun each day.
If your cactus isn’t receiving the proper amount of sunlight, it will begin to display signs of weakness and discolorations such as:
- Paleness or other discoloration
- Stems begin to stretch out to reach more light
- Cactus isn’t blooming or producing fruits in season
- Branches become weak or squishy
- Hairs look dull or browned
On the other hand, a cactus that receives adequate light will:
- Be a vibrant deep green
- May produce colorful flowers and fruit
- Have visually strong stems, needles, or hairs
Placing your indoor cactus in a south-facing window will ensure that it receives enough light during the day. Most cacti will not need direct sunlight and can thrive on indirect light, so just as long as the window is receiving bright, indirect light, your cactus should do well.
As for outdoor cacti, it’s best to plant them in an area that is shielded from intense, direct sunlight at the hottest hours of the day. For example, plant your cactus in an area that is shaded around noon, but receives around 6 hours of sunlight in the afternoon and evening.
The Effects of Too Much Sun
If you place your cactus in an area that receives too much sun, especially the direct sun, you risk sunburn damage to your plant. Sunburn in cactus manifests itself in brown or yellow spots on the pads of the cactus and will also lead to a dried appearance if the problem isn’t remedied.
An excellent way to combat the effects of sunburn is simply by moving your cactus to another area or by planting taller, thicker plants, such as desert shrubs, next to the cactus to block any harsh sunlight. You’ll want to act swiftly, though, because sunburn in cacti happens rapidly and will end in an unfortunate demise for your plant if nothing is done.
Because cacti were created to retain water for extended periods, they also suck any moisture up quickly and won’t need to have wet soil to stay healthy. In fact, moist soil will actually cause root rot in cacti, so it’s essential to plant your cactus in a soil that drains well to avoid any health issues.
Sandy or gravelly soil is best and is especially useful for seasons where rain is frequent or abundant. This is because well-drained soil allows any excess moisture that may be provided to your cactus to move away from the roots, protecting them from pooling and rot. You can either find a premade cactus soil online or at your local plant nursery or substitute ⅓ of your regular potting soil with sand to create the ideal soil for cacti.
The Best Soil for Cacti
Our favorite cactus potting mix is the Hoffman 10404 Organic Cactus and Succulent Soil Mix. It’s formulated with both jungle cacti (like Christmas Cactus) and desert cacti in mind, providing the proper drainage to allow your cactus to get adequate water without puddling excess moisture at the roots.
It’s also organic, meaning that it’s a healthier formula not only for your cacti but also for the earth and your family. Lastly, it contains an abundance of nutrients to encourage growth, vibrant colors, and brilliant floral blooms in the spring and summer.
What We Like:
- Affordable, even for those that may be on a budget
- Formulated organically for a safer product
- Contains a wide variety of nutrients to keep your cacti looking its best and prolong the life of your plant
- Drains properly without stripping moisture from your cactus
- Perfect for both desert and jungle species
Fertilizing Your Cactus
There is a time and place for everything, and that includes fertilizing your cactus. Cacti should be fertilized, but infrequently (only once every 2 to 4 weeks), and only in the spring when the plant is growing and preparing for the upcoming months of dormancy.
Fertilizing your cactus in the spring will help it to store essential nutrients to sustain itself whenever nutrients are scarce in the winter. You don’t want to fertilize your cactus during the harsher months of summer and winter because your plant’s primary focus during those times is to stay alive rather than grow.
The Best Plant Food for Cacti
Of course, you should always opt for a fertilizer that is formulated especially for succulents and cacti. We suggest the Miracle-Gro Succulent Plant Food for indoor cacti. It’s very affordable for all gardeners (even the budget-conscious) and works well to provide instant nutrients to your plants.
This fertilizer is a liquid and comes in an easy-to-use pump bottle. You can apply it directly to the soil or mix it with water the next time you water your cactus to give it an additional boost. It’s recommended that you use this fertilizer once every two weeks for cacti that have been relocated to a new area of your yard, repotted, or brought indoors after being purchased.
Once your cactus plant is established in its new home, you can lengthen the amount of time between fertilizing to 4 weeks or a month. Take special care not to apply this fertilizer directly to the cactus, as it will cause chemical burns on the pads.
What We Like:
- Affordable, lasting fertilizer
- Perfect for both new and established cacti
- Only needs to be applied every 2 to 4 weeks for best results
- Encourages rapid, but healthy, growth and blooms if applicable to your cactus species
- Simple, pump-action bottle
- Can be applied directly to the soil or mixed with water
- Instantly provides top-notch nutrients to the soil for the cactus’s roots to absorb
Overall, the Miracle-Gro formula for cacti is an excellent option for potted cacti or outdoor cacti that aren’t receiving the nutrients they need from the soil.
Maintaining Cacti During the Cold Months
No matter how well you care for your cactus during the spring and summer, when winter strikes, it can be a death sentence for many cacti species. Though there are cacti that can withstand temperatures sometimes as low as -30 degrees Fahrenheit, the majority of cactus species on the market for home gardening can only survive down to freezing — and for very short periods.
It’s essential to take the necessary precautions before winter rolls around to prevent frostbite or potential withering of your cactus. Care (watering, light, and temperature) for your cactus also changes slightly from care during the rest of the year.
In the next few sections, you will learn how to care for your indoor and outdoor cacti in the winter.
Caring for Your Indoor Cactus
Winter is the dormant season for cacti, meaning their processes naturally slow to keep them from expending energy and nutrients during the harsh season. Indoor cacti have the advantage of not being directly exposed to outdoor elements. However, with the decrease in light and increase in the frigid temperatures, there is some improvising involved in its care.
- If your cactus isn’t getting 4 to 6 hours of sunlight during the winter,try using a grow light to supplement the lack of sun it’s getting.
- Keep watering your indoor cactus regularly. Watering during the winter should be as often as you do around the year (about once a month).
- The indoor temperature should be a warm, comfortable 65 to 70 degrees Fahrenheit. Cold spells can kill a cactus, so keep the temperature of your home consistent.
- If your cactus is by a frequently-used door to the outside, move it. Once again, cold bursts of air can potentially harm your cactus. It’s best to move it as far away from the chilly outside world as possible.
- If your cactus usually sits close to a window, move it a little farther away. Glass gets chilly, and having your cactus too close to a window can make your plant colder than it needs to be.
- When you water your cactus, use room-temperature water rather than cold water from the tap.
Caring for Your Outdoor Cactus
Because your outdoor cactus is in direct contact with the icy elements, there will be a bit more work to do on your part to keep it from too much exposure. Frigid winds can lead to frostbite in exposed cacti, and too much snow can lead to both surface and root rot once it begins to melt.
- Cover your cactus in burlap sacks. The burlap sacks are porous enough to allow sunlight to come through, but thick enough to keep some heat in and protect the cactus from snow, ice, and wind.
- If your winters are particularly harsh, consider a plant house. Pop up greenhouses, like this flower house, help to increase the temperature around the cactus and protect from winter elements without blocking sunlight.
- Do not water your cactus. Watering an outdoor cactus during the winter will almost certainly kill it because of the water freezing inside of the cactus. Instead, water consistently during the months leading up to winter so that your cactus has enough stored in its cells to survive.
- If your winters aren’t too bad and you have a large, potted outdoor cactus, you can move it to a covered deck to block it from the wind and snow.
The Toughest Cacti Species for Forgetful Gardeners
If your thumb just doesn’t turn green no matter how hard you try, the following hard-to-kill cactus plants may be the perfect choice for giving you a lively indoor or outdoor garden — with as little effort as possible on your part.
One of the most popular cacti species among desert gardeners, the Barrel Cactus, is hardy and cute. This Mexican desert-native can endure winters of mild frost and scorching temperatures. Their sizes can vary and can either sit low to the ground or grow as tall as 10 feet and 3 feet wide.
They do well both indoors and outdoors and can withstand direct sunlight for upwards of 6 to 8 hours. They won’t need to be watered, but once every 3 to 4 weeks if indoors and, if outdoors, rainfall will keep this beautiful cactus going with no problems whatsoever (in most North American regions). Sufficient water in the spring will result in a large yellow flower.
Barrel Cactus also won’t need any fertilization, as they naturally grow in low-fertile areas. If you want to keep it looking vibrant, you can fertilize it once a year during the spring.
Found in all of the deserts of the American SouthWest, Prickly Pear has adapted to survive harsh summers, and some varieties have even adapted to withstand the cold of winters further north (as low as -35 degrees Fahrenheit!).
These cacti are a fantastic option for an outdoor garden because they:
- Do well in full, direct sun
- Only need watering when the soil is dry and rainfall is infrequent
- Can grow several feet wide and tall over time
In the spring and summer, with enough rainfall, Prickly Pear Cactus will bloom bright yellow flowers and, later on, edible fruits.
Chollas is a SouthWest American desert native cactus that:
- is drought-resistant
- can withstand temperatures as low as 5 degrees Fahrenheit
- is tolerant of full sun conditions
- has moderate watering needs and little overall care requirements
Chollas is probably one of the toughest cacti on the market and won’t need to be watered often. Too much water is the problem this cactus species faces the most, as they’re incredibly prone to root rot. Watering only whenever droughts are persistent is all that’s needed for Chollas if they’re outdoors.
While you can have chollas indoors, it is strongly advised against, as its tiny, thin, and clustered barbs are prone to sticking to anything and everything and are extremely painful to remove, digging deeper into the skin with every tug. It is recommended that you plant these tall-growing plants away from your home or at the rear of a desert garden.
One of the longest-living cactus species in the world, the Saguaro Cactus, is said to live as long (or longer) than people do. Some are even as old as an estimated 200 years! This cactus is as tough as they come and can withstand drought and hours of direct, hot sunlight.
Rainfall is more than enough to keep this cactus thriving, as it has such a large capacity for water storage — enough to allow it to bloom creamy white flowers every year, regardless of the amount of rainfall during the rainy season.
Though slow-growing, these cacti have the potential of reaching 30 feet in height and several feet in diameter, so it’s best to plant them outdoors in an area that is well-drained and receives a lot of light.
5. Pencil Plant
Native to African deserts, the Pencil Plant is no stranger to high heat and harsh conditions. When water is plenty, they’re green in color, but when lacking water, turn a bright coral color. It’s not at all uncommon for gardeners to purposefully restrict water from their Pencil Plants to achieve these brilliant colors, and this cactus does perfectly well without the abundance.
Rainfall is generally enough for this cactus. However, you can water it once a month if the summers are too hot. Plant in an area that receives partial to full sun.
When a cactus begins dying, it comes down to basic care. Cacti are such resilient plants that it’s practically impossible to kill them unless you’re merely caring for them too much. Overwatering is one of the most common mistakes new gardeners make with these desert plants, as root rot is an actual reality with these species. Take care to provide your cactus with adequate sunlight, water only when necessary, and keep it out of direct cold elements.
Some species require more care than others. If you find yourself unable to care for your cactus correctly, consider purchasing one of the previously mentioned species. Cacti like Saguaro Cactus don’t require much upkeep and can live in an arid environment for decades.
Last update on 2023-10-05 / Affiliate links / Images from Amazon Product Advertising API

domain: agronomy


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Vascular Therapies Appoints John McDermott as Chief Executive Officer
January 10, 2019—Vascular Therapies, Inc. announced the appointment of John McDermott as the Company’s Chief Executive Officer. Mr. McDermott previously served as Chief Executive Officer of Endologix, Inc., President of Bard Peripheral Vascular, and Chief Operating Officer at Impra.
Vascular Therapies is a privately held clinical-stage biotechnology company focused on improving outcomes for patients with advanced kidney disease. The company is developing a sirolimus formulation for local, perivascular drug delivery to address vascular anastomosis failure. This investigational therapy is currently being evaluated in phase 3 randomized clinical trial, which is being performed under a Special Protocol Assessment. The drug development program has received Fast Track status from the FDA and sirolimus has Orphan Drug status for the dialysis vascular access indications in the United States and European Union, advised the company.
Bob Croce, Chairman of the Board of Directors of Vascular Therapies, commented in the announcement, “We are very pleased to welcome John as our Chief Executive Officer. John has nearly 30 years of experience in the vascular industry and has led the development and successful commercialization of multiple ground-breaking new technologies. Dr. Sriram Iyer, the founder of Vascular Therapies, has done an excellent job leading the company since inception and will continue as its Chief Scientific Officer.”

domain: medical


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Home video changed the world. The cultural and historical impact of the VHS tape was enormous. This film traces the ripples of that impact by examining the myriad aspects of society that were altered by the creation of videotape.
Jack Rebney is the most famous man you've never heard of - after cursing his way through a Winnebago sales video, Rebney's outrageously funny outtakes became an underground sensation and ... See full summary »
For three weeks in September 2008, one person was charged with preventing the collapse of the global economy. No one understood the financial markets better than Hank Paulson, the former ... See full summary »
In 1968, Pittsburgh native, George Romero, would direct a low budget film that would revolutionize the horror genre forever, Night of the Living Dead. Through interviews with the talents involved, the story of this film creation is told and how it reflected its time with a grotesque and powerful immediacy. Furthermore, the film's difficult and controversial release to an unsuspecting film public is also recounted as it survived the early revulsion to become a landmark cinematic creation with a profound effect on popular culture. Written by
Kenneth Chisholm (email@example.com)
A little more George, a little less of everyone else.
While I am certainly no fan to zombie films in general because the genre has been WAY over-saturated in recent years, I have enjoyed a few of the films and understand that they still are very popular and important films despite my misgivings about many of the recent films. So, because of this, the new documentary Birth of the Living Dead is well worth seeing and is rather timely. It is THE granddaddy of all modern zombie filmsthe one that led to subsequent generations of such pictures. In fact, it's one of the most important movies of the 1960s and it's one every film student and horror fan should see and appreciate. It managed to overcome its low production values and humble origins to become a cult favorite.
Not surprisingly, the creator of the original film, Night of the Living Dead, George Romero, is featured in this documentary. When he's being interviewed is when the film is at its best. His tidbits about the making of Night of the Living Dead are really interesting and I wanted even more of this than Romero provided. Additionally, a variety of experts are interviewed and they discuss what they love about the movie. Also not surprisingly, various clips from this seminal film are shown throughout this homage. Among the topics covered are the director's expectations as well as how he made the film, the impact of the film on pop culture, the reaction of the critics (both immediately after the film was released and later after many re-assessed the movie), the political and racial themes in the film (whether intended or not) and how the film was groundbreaking as well as how it mirrored the times in which it was made.
This documentary certainly is well worth seeing and I recommend you see it provided you first see the old film it's based onotherwise it might be a bit confusing. However, it's not a perfect making of film and could have been a bit better. As I mentioned above, the inside information from Romero was great but too often various 'experts' (and I have no idea what constituted this in many of the folks chosen to discuss the film) talked a lot more about hidden social significance (something that Romero revealed is NOT always in the movie) and the times instead of talking more about the original movie itself and how it was made. Still, despite this, the film is reasonably well made and kept my interest throughout. For horror fans and film students, it certainly should be a film to watch.
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domain: entertainment


text: Biomarkers are a fundamental element of tumor administration with their make use of in risk evaluation thanks, screening, differential analysis, prognosis, prediction of response to treatment, and monitoring improvement of disease. in nearly every human being tissue. This development has resulted in not only guaranteeing results with regards to patient result, but in addition has resulted in an exponential development in the analysis of fresh biomarkers that may potentially be used in CAR T cell therapy for dealing with patients. With this review, we discuss the biomarkers presently under analysis and explain several guaranteeing biomarkers in the preclinical stage of advancement which may be useful as focuses on. Tumor biomarkers experienced a successful useful for a number of different facets of tumor individual treatment historically. With the arrival of immunotherapy, surface area tumor biomarkers are becoming utilized as restorative focuses on to immediate and orchestrate an immune system response inside a cancer-specific style Open in another windowpane Fig. 2 Current CAR T cells in medical trials. From the original achievement of Compact disc-19 engine car T cell therapy, several fresh biomarker focuses on have emerged and so are becoming examined in medical trials. This development of focuses on has extended CAR T cell therapy to the treating not only hematological malignancies, but also to solid tumors aswell Surface biomarkers possess expanded significantly during the last 10 years CAR T cell therapy was conceptualized in 1989  and was named an effective restorative after targeting Compact disc19 for the treating lymphomas and leukemias [7C9]. This resulted in an exponential development in CAR therapy so that as a direct outcome, in surface area biomarker finding (Fig.?3). In 2012, there have been a complete of 5 medical trials, four focusing on Compact disc19 and one focusing on Mesothelin. This quantity has continuing to develop and the amount of biomarkers examined in a medical setting in addition has extended from 2 to 25. The entire yr 2017 noticed even more medical tests than any earlier yr with 111 initiated, focusing on 17 different biomarkers (Desk?1). This development demonstrates Zosuquidar not merely the effectiveness of CAR T cell therapy, but also the large press in immunotherapy to discover fresh and better focuses on. Open in another windowpane Fig. 3 Clinical trial Biomarkers by Might 2018 by yr. CDH5 The development of CAR focuses on is demonstrated as the variety and amount of medical trials offers exponentially improved from 2012. Not merely are there even more medical trials making use of CAR T cell therapy, there’s also even more focuses on becoming evaluated Desk 1 Current Clinical Tests (by Apr 2018) . Pursuing Phase I medical tests, no anti-PSMA toxicities had been mentioned and 40% of individuals achieved medical partial reactions (PR) . Recently, PSMA CAR T cells have already Zosuquidar been designed to withstand TGF suppression, which is situated in prostate malignancies frequently, via a adverse TGF receptor II . In individuals Zosuquidar with castrate metastatic prostate tumor, PSMA-CAR T cell therapy isn’t just safe, but individuals experience cytokine creation suggestive of persistence of T cells in the bloodstream for 2?weeks (“type”:”clinical-trial”,”attrs”:”text”:”NCT01140373″,”term_id”:”NCT01140373″NCT01140373) . ROR1 Receptor tyrosine kinase like orphan receptor 1 (ROR1) can be a Wnt5a surface area receptor indicated during embryonic advancement, but absent from adult cells apart from adipocytes generally, gut, pancreas, and parathyroid glands [228C230]. In the entire case of tumor, ROR1 shows high levels in a number of solid malignancies: pancreatic [231, 232], ovarian [231, 233C235], breasts [231, 236C238], lung [231, 239, 240], gastric tumor , and colorectal tumor . High degrees of ROR1 show strong relationship to poor affected person outcome and to developing metastasis [235, 243]. There’s been some conflicting preclinical research where CAR T cells focusing on ROR1 have proven serious cytotoxicity as the cells gathered inside the lungs . In the meantime, other research show great achievement in focusing on ROR1, which might be a direct reason behind the specificity from the.


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Background: In the UK, spontaneous reporting of suspected adverse drug reactions (ADRs) by healthcare professionals has been in operation since 1964 through the Yellow Card Scheme (YCS). From 2005, patients themselves have been able to submit Yellow Card reports.
Objective: To compare patient characteristics, suspected drugs and suspected ADRs reported by patients with those reported by healthcare professionals using the YCS.
Design and Setting: Retrospective observational study in the UK.
Methods: Participants were patients reported to the Medicines and Healthcare products Regulatory Agency (MHRA), either by themselves, a representative or a healthcare professional, as having one or more suspected ADRs between October 2005 and September 2007. The main outcome measures were ADRs and time taken to report.
Results: In total, 26 129 Yellow Card reports from patients and healthcare professionals were received from the MHRA for the 2-year study period (19.8% patient and 80.2% healthcare professional). More Yellow Card reports were made for female than male patients (p < 0.001). Patients reported a significantly higher number of suspected ADRs per report than healthcare professionals (median [interquartile range IQR] of 3 [2–5] vs 2 [1–3], respectively; p<0.001). A higher proportion of patient reports (16.1%) contained more than one suspect drug than healthcare professional reports (9%; p < 0.001). Healthcare professional reports had a higher proportion of ADRs that caused hospitalization (18.8% vs 12.9%), were life threatening (11.1% vs 6.2%) or caused death (2.6% vs 0.7%) than patient reports (all p<0.001). Patient reporters took a significantly longer time to report their reaction than healthcare professionals (median [IQR] of 104 [27–463] vs 28 [13–75] days respectively; p<0.001). Direct comparisons of the seriousness of the ADRs were not possible because of important differences between patient and healthcare professional versions of the Yellow Cards.
Conclusions: This is the first substantial, published study in the UK to compare Yellow Card reports from patients and healthcare professionals. Whilst patients report more suspected ADRs to more suspect drugs than healthcare professionals, healthcare professionals tend to report more serious reactions that result in hospitalization, are life threatening or cause death. Further research is required to investigate the extent to which the extra information from patient reporters contributes to signal identification when assessing drug safety.
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Medicines and Healthcare products Regulatory Agency (MHRA). Evaluation of patient reporting to the yellow card system [online]. Available from URL: http://www.mhra.gov.uk/home/idcplg?IdcService=GET_FILE&dDocName=CON2023599&RevisionSelectionMethod=Latest [Accessed 2010 Feb 23]
House of Commons Health Committee. The influence of the pharmaceutical industry. Fourth report of session 2004–5. London: The Stationery Office, 2005 Apr
Yellow Card Scheme —MHRA [online]. Accessed from URL: http://yellowcard.mhra.gov.uk// [Accessed 2010 Jun 1]
Medicines and Healthcare products Regulatory Agency (MHRA). Patient reporting of suspected adverse drug reactions [online]. Available from URL: http://www.mhra.gov.uk/Safetyinformation/Reportingsafetyproblems/Medicines/Reportingsuspectedadversedrugreactions/Patientreporting/index.htm [Accessed 2010 Feb 18]
Brown EG, Wood L, Wood S. The medical dictionary for regulatory activities (MedDRA). Drug Saf 1999; 20: 109–17
World Health Organisation (WHO). The Anatomical Therapeutic Chemical Classification System with Defined Daily Doses (ATC/DDD) [online]. Accessed from URL: http://www.who.int/classifications/atcddd/en/ [Accessed 2009 Apr 24]
Perry BA, Turner LW. A prediction model for polypharmacy: are older, educated women more susceptible to an adverse drug event? J Women Aging 2001; 13(4): 39–51
Davies EC, Green CF, Taylor S, et al. Adverse drug reactions in hospital in-patients: a prospective analysis of 3695 patient-episodes. PLoS ONE 2009; 4(2): e4439
Zopf Y, Rabe C, Neubert A, et al. Women encounter ADRs more often than do men. Eur J Clin Pharmacol 2008; 64: 999–1004
Egberts TCG, Smulders M, de Koning FHP, et al. Can adverse drug reactions be detected earlier? A comparison of reports by patients and professionals. BMJ 1996; 313: 530–1
Foster JM, van der Molen T, de Jong L-van den Berg L. Patient-reporting of side effects may provide an important source of information in clinical practice. Eur J Clin Pharmacol 2007; 63: 979–80
Jarernsiripornkul N, Krska J, Richards RME, et al. Patient reporting of adverse drug reactions: useful information for pain management? Eur J Pain 2003; 7: 219–24
Basch E. The missing voice of patients in drug-safety reporting. N Engl J Med 2010; 362: 865–9
Waller PC. Making the most of spontaneous adverse drug reaction reporting. Pharmacol Toxicol 2006; 98: 320–3
The Yellow Card Study Collaboration also includes Heather Fortnum, Alison Gifford, Janet Krska, Elizabeth Murphy, Tim Payne and Saad Shakir. Thanks to the Yellow Card Study Collaboration Advisory Group for their feedback. Thanks to the Medicines and Healthcare products Regulatory Agency for providing us with their data and assisting with any queries.
D.J. McLernon conducted the statistical analyses, drafted and finalized the paper. He is the guarantor for the paper. A.J. Lee, P.C. Hannaford, C.M. Bond, M.C. Watson and A. Avery contributed to and oversaw the design and conduct of the study, and contributed to the writing of the paper. L. Hazell prepared and coded the database, and contributed to the writing of the paper. All authors had full access to all of the data and can take responsibility for the integrity of the data and the accuracy of the data analysis.
This research was supported by the UK National Health Service Research & Development Programme Health Technology Assessment Programme (project number 06/92/03).
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Cite this article
McLernon, D.J., Bond, C.M., Hannaford, P.C. et al. Adverse Drug Reaction Reporting in the UK. Drug-Safety 33, 775–788 (2010). https://doi.org/10.2165/11536510-000000000-00000
- Healthcare Professional
- Adverse Drug Reaction
- Adverse Drug Reaction Reporting
- Suspect Drug
- System Organ Class

domain: literature


Live in the south wind is an exploration of the wefts of memory that remain embedded within places. Zhu Baolei moves in search of the archive of Nanning, a city located in the south-western border area of China, corroded, like so many, by the transformations of urbanisation. In old buildings hidden in the dense urban landscape, disused objects and old photographs guard the history of a city and a generation, resisting the ever-changing spatial memory between abandonment and reconstruction, secrecy and disappearance, transformation and separation. Through photography, the author redeems the anonymous role of places destined for insignificance and destruction. Thus, a mnemonic gate is thrown open in which the remains of objects and human traces, like “wrinkles” of time shaped by deformation, open up a reflection on the changing interaction between the individual and space.
“The abandoned building is not an isolated spectacle but an unrevealed corner of the city. Tearing down a building does not only mean demolition in the material sense but also means that all the people and things attached to and occuring in these old buildings would be submerged along with this process.” ― Zhu Baolei
The formal structure of the volume emphasises the idea of preservation that runs through the entire project, submitting three photographs preserved in special envelope attached to the back cover.


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Sugar is universal and too often insatiable desire, whether for children or adults. But the negative effects of sugar on the body, such as excessive insulin secretion, damage to brain functions, obesity, and so on, leave many people wishing there was a way to make sugar healthier.
Enter Korean businessman Kwan Jai-won. Kwan traveled to South America for a business trip. and chanced upon organic raw sugar.
During his trip, Kwan came down with a cold. To get back on his feet as soon as possible, he asked his friends to get some cold medicine for him. He was surprised when they brought him a cup of warm sugar water instead: “I was sweating a lot that night, but I felt much better the next day,” he recalled.
Nobody would suggest drinking processed sugar water for a cold, especially since there is evidence sugar can affect the immune response to bacterial infections, but in South America, raw sugar is considered an effective medicine for children when they get sick.
Raw sugar is made from sucrose, but in the production process does not undergo chemical refining or other additional treatment, so it isn’t extremely sweet, and retains more of cane sugar’s nutritional value, such as minerals and vitamins.
With this experience, the idea of introducing raw sugar to South Korea began to germinate in Kwan’s mind.
Many soccer players drink raw sugar water before games for steady energy thanks to the fact it doesn’t cause the same spike in blood sugar as refined sugar.
“This is the reason why the [South American] athletes drink mineral raw sugar before playing, because energy and nutrition is slowly released into the body, allowing physical fitness throughout the entire game,” said Kwan.
Going against the grain of common belief that sugar automatically equals unhealthiness, Kwan believes that raw sugar is an indispensable health food in South America. Whether sugar is good or bad for you is closely related to how the sugar is made.
Consuming too much refined sugar causes well-documented harm to the human body.
It can cause excessive insulin secretion and lead people to develop obesity.
Refined sugar contains increased sucrose content and is void of minerals and vitamins.
Eating refined sugar causes blood sugar levels to rise rapidly. The glycemic index (GI) reflects the degree of blood sugar elevation caused by different foods, that is, the level of blood sugar production following food intake. GI is used to measure the rate at which food is digested and absorbed and its effect on blood sugar. When people consume foods with high GI values, the sugar is digested and absorbed quickly, and the blood sugar rises rapidly in a short time. Kwan said:
Refined sugar (sucrose) has a GI of around 65 while raw sugar has a GI of around 50, over 20 percent lower.
The sucrose content of raw sugar is also lower than that of refined sugar thanks to the nutrition of the unrefined sucrose, which contains vitamins and minerals like calcium, potassium and magnesium, as well as protein, amino acids, and even antioxidants. Because there is no refining, the raw sugar is also absorbed into the body more slowly, reducing the sudden rise in blood sugar levels.
Introducing South American Sugarcane to Korea
Kwan wanted to bring the South American method of making raw sugar to Korea so South Koreans could enjoy a healthier form of sugar. In March 2011, he started to conduct research. Six months later, he founded the Auno company.
Auno is the first Korean company to import organic South American sugarcane for raw sugar processing. The South Korean Food and Drug Administration has also developed domestic raw sugar standards. Auno became the only company in South Korea to grow sugarcane and then produce raw sugar locally.
The raw sugar Auno produces is called “Auno Organic Mineral Raw Sugar.” The sugarcane is organically grown in the high mountains of Colombia. No chemical fertilizer is used. The sugarcane grown here is rich in mineral content. Using the traditional Indian method of extracting cane juice, the production process only uses physical pressing methods, no chemical means and no refining. After heating and evaporating some of the water in the cane juice, the hardened sugar is placed in a conventional environmentally friendly container for grinding, yielding the fine, light brown gains of Auno Organic Mineral Raw Sugar.
Kwan tried to add nutrients to white sugar to see if it could have the same effect as mineral raw sugar. But the experiments showed that artificial additions could not match the nutritional effects of raw sugar. Kwan realized that the natural product was the most perfect.
“People get sick because they eat too much food with chemical additives. If what they eat is in accord with natural laws, then there won’t be any problem,” Kwan said.
More and more diseases are caused by chemically processed foods that cause harm to the human body. The travesty of chemically processed products comes from gluttony and financial interests.
“Many people think that eating sugar is not good. This is because people pursue sweetness. They focus on sugar that is chemically refined again and again for maximum sweetness. Although eating this sugar provides immediate gratification, it’s a huge amount of concentrated sugar entering the body, which creates a burden.”
Auno Organic Mineral Raw Sugar is intended to replace the conventional sugar in daily life, such as that used for bread, coffee, and desserts. Major department stores in South Korea have included Auno products in the high-quality product line, occupying the highest local market share among similar products in the country.
Auno has used the raw sugar it produces to create a Auno Grano.
This snack is made with Auno sugar and a selection of grains such as oats, buckwheat and basil. It cooks these with a puffing technology to preserve the natural nutrients of the ingredients.
For those who are concerned about their calorie intake, there is no need to worry when eating Auno Grano. The packaging is light and comes with a plastic spoon, so that adults and children can open and close it at their convenience and even add milk, or another liquid without fear of it leaking. With milk or soy milk added, the flavor of soaked grains is something to savor.
Later, Auno also used organic raw sugar to make a healthy peanut candy: Auno Nutdy.
In the last couple years, the Korean market has seen the introduction of various raw sugar products, and Korean consumers have gradually become familiar with mineral raw sugar as a concept.
“Several exhibits have found that many consumers will use our products as a benchmark against other brands,” Kwan notes. As the pioneer of the Korean mineral raw sugar market, he is very pleased that Auno, which holds the natural and healthy as its root principles, has been able to earn and keep the people’s trust.
For more information visit: edninfo.com.
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Auno Organic Mineral Raw Sugar can also be purchased via Amazon.com

domain: food


WHAT CALIBER, BRAND, SIZE - PISTOL OR REVOLVER?
As I teach concealed weapon courses, these are questions I am asked all the time. They are not new and the answers are as controversial as they are numerous. I have pondered these questions to try and give my students and/or proposed gun buyers the best information they could have as they cross that bridge. Some people are sold on the most costly guns, while some others are just as pleased with a low dollar, fairly well-known gun that they feel best fits their needs. Others are sold on 1911's and you will never change their minds. Some love Glocks while some hate them or are scared to death of them. Some guns jam because of the quality, others because of the user and some only because of cleanliness or poor ammunition. It could be a defect in workmanship or material, even damage done after purchase. I've seen them all fail on the range. Some are pop guns and others are engine block busters. Some fit on your belt buckle while others are labeled "hog-legs."
I don't care to say a semi-auto is better than a revolver or vice-versa. I don't care to endorse a brand because of its time on the planet or high cost. I don't necessarily think one bore is "better" than the other, depending on the users' expectations and abilities. Ideally, the most expensive gun "should" be the best. The biggest caliber with the best knock down power and/or penetration capability should be the most desirable. The easiest to conceal should be the best choice or the biggest gun would scare the most people when drawn. Some of these expectations are kind of funny when you think about them.
I have assembled my own top 16 factors I believe a person should consider when contemplating purchasing a new handgun. You may not agree with all of them and that's okay, because I am confident there will be other people that will. We each are entitled to our own opinions. I have tried to assemble these factors in somewhat of a priority order though they might change for some people. I will also make comments as needed. I am sure many people before me have thought about and written about this issue and I have borrowed parts from some of them but developed most as my own.
Reliability – Is this gun/manufacturer known by gun professionals to be reliable?
(You are possibly buying this gun to save your life. Make sure you are confident it will work when you need it.)
Purchase cost – Is this gun the best I can buy for the maximum money I can spend on one?
(Not always, but cost often equates to quality so buy the most expensive one you can afford - spend money on it like your life depends on it. However, you may not be able to afford much and any gun might be better than no gun.)
Usage cost – Will the cost of the ammo be cost-prohibitive so I won’t be able to practice/become proficient?
(To become proficient, you will need to practice often, so buy a gun that you can also afford ammunition for. Having a gun you can't afford to shoot is like having a HUM-V you can't afford to buy gas for. You have to be able to practice so that when the need arises to save your life, you will have achieved that proficiency level.)
Convertability – Are conversion kits available that will allow me to convert it to a .22 to reduce costs?
(Many guns today of large caliber can be converted to a .22 in order to save money on ammunition and practice more without tearing your hand off.)
Fit – Does it fit my hand well and allow my trigger finger to fit the trigger properly?
(If you can't hold it properly or fit your finger in the right spot on the trigger it is of little value to you.)
Weight – Is it so heavy with rounds loaded that it will pull my pants down or weigh my purse down?
(A gun too heavy to carry is useless. High capacity magazines and large bore rounds add to the problem.)
Concealability – Is it small enough that I will not hesitate to carry it on my person all the time wherever I go?
(If the gun is not concealable under most conditions, you will leave it home or in your vehicle. Murphy's Law can kick in and it may not be available to you the very instant you need it.)
Caliber – Does it have knock down power and penetration acceptable by the law enforcement community? One argument might be to get the biggest bore you can for the money you have and a holster big enough to carry it in.
(Knock down power is a $64 dollar question sometimes haphazardly demonstrated on metal plates or water jugs; penetration is usually accepted as the ability to penetrate a 20 percent gel block at least 10 inches. However, here is my most debatable response: Shot placement is more important than caliber. As a child I killed pigs when harvest time came, by shooting them between the eyes with a .22 short. They dropped instantly except the one time the pig moved and I hit above one eye, resulting in total destruction of the pen and the need for 7 or more .45 caliber rounds. Police officers shoot suspects all the time, multiple times and they keep coming. A properly placed .22 derringer shot in the head is more effective than 6 shots from a .44 Magnum Clint Eastwood special on the limbs or non-lethal areas of the body.)
Ease of Use – Does it lack simplicity to the point that it may be confusing during a firefight?
(One easily confused might want a revolver that only requires the pull of a trigger while others may be okay with multiple functions.)
Snagability - Some guns have sharp hammers or hand protector fins like those found on 1957 Chevrolet's that may snag on your clothing or purse as you try to draw it quickly in a life-threatening situation.
(You can be the best World Class shooter known to man, but if you can't get the weapon out in time to put a properly placed shot on the perpetrator before he fires at you, in all likelihood, you won't live to tell about it. Learning and being able to "quick draw" is not a silly or cowboy skill, rather a survivability skill.)
Features - Does it have a de-cocking mechanism, ambidextrous safety, night sights, rail for flashlight/laser beam (red or green)?
(De-cockers might be needed more by the inexperienced users than others and safety needs differ for individuals. However, most shootings occur within 21 feet or less of the perpetrator and sights, or beams of any kind are rarely of any value at that distance. Night sights light up the target but not the suspect. Too much time spent other than "Point Shoot" may result in your death because you are already "reacting" to a perpetrator's actions in most cases and fractions of a section count. If you are the type of person that shoots with sights of any kind, then your concentration should be on the front blade, not where the bullet is hitting as would be the case with a beam sight. Most police officers interviewed in post shooting situations never remember using the sights, recoil or sound. They often can't even remember the number of shots they fired. Time distortion, auditory blocking and tunnel vision kick in with the flow of adrenaline. Many of those things taught and practiced on the range go out the window when you are facing a violent, vicious killer trying to take your life rather than a harmless, one dimensional, paper man standing still on a range.)
Functionality - Will it fire without the magazine, does it show me from the outside that a round is in the chamber?
(You may want to drop the magazine in a struggle to prevent a gun from firing-some do. You may not want to drop the magazine to see if a round is in the chamber or risk pulling it partially back.)
Finish - Am I satisfied with the material, blue steel, stainless, polymer, two tone, etc., and is it of a durable type?
(Some finishes are personal preference, others are required due to the conditions they are handled in.)
Serviceability – Is it in use enough to the point that most local gunsmiths would be able to work on it?
(Some new guns hit the market for a good price with promising careers but may be so new that parts are not available or expertise may not be available to work on them.)
Warranty – Is there a warranty and if so, how long does it last; does it include parts, labor, shipping?
(Some manufacturers have no warranty; others do with different time limits, but may differ on who pays for parts and who pays for labor and who pays for shipping? In the end, maybe you could have bought a higher dollar gun with less hassle.)
Value – Does it hold its value to the point that I can re-sell it a couple of years later without losing money?
(Most name brand guns are good investments and hold their values. You may trade at a gun show or with a local dealer and get a good trade-in value, but remember they are in a retail business and have to make money too so they won't give you retail dollars for it. However, some people out there don't like paper-work trails and may pay you more for the gun as an individual sale without paperwork, than they would buying it new from a dealer with the paperwork trail.
I have provided this information for one reason only; that is to help people decide what is best for them. What is good for one person is not necessarily the best choice for another. I have tried to make this simple but informative. I hope it helps. Your comments are welcomed.


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The American Water Charitable Foundation, a 501(c)(3) organization established by American Water, the largest publicly traded U.S. water and wastewater utility company, announced today it awarded a combined total of $1.5 million to 36 organizations in 12 states, supporting communities served by American Water through the 2022 Water and Environment grant program.
“The American Water Charitable Foundation is pleased to partner with organizations across American Water’s footprint to provide equitable and accessible projects and programs focused on clean water, conservation, environmental education and water-based recreation,” said Carrie Williams, president, American Water Charitable Foundation. “The Water and the Environment grant program gives us the opportunity to continue to focus on our core passion of water, while engaging community members in learning how every drop counts.”
The Water and the Environment grant is part of the Keep Communities Flowing Grant Program, which focuses on three pillars of giving: Water, People and Communities. The total award of $1.5 million will support high-impact projects and initiatives that further American Water’s commitment to support ESG (environment, social and governance), as well as inclusion, diversity and equity.
Grant recipients impact communities that align with American Water’s regulated state subsidiaries in California, Illinois, Indiana, Iowa, Kentucky, Maryland, Missouri, New Jersey, Pennsylvania, Tennessee, Virginia and West Virginia. Regional events to celebrate local efforts, forthcoming.
The 2022 Water and Environment grant recipients are: Bluegrass Greensource Inc., Boys & Girls Club of Jefferson City, Brandywine Health Foundation, City of East Ridge, Coalfield Development Corporation, Downtown Country Christmas Festival Inc., Eastern Pennsylvania Coalition Abandoned Mine Reclamation, Falls of the Ohio Foundation Inc., Friends of the Lower Appomattox River Inc., Friends of the Occoquan, Friends of the Pittsburgh Urban Forest, Friends of the Water Conservation Garden, Girls Inc. of Greater Philadelphia and Southern New Jersey, Hazelwood School District, James River Association, Kanawha State Forest Foundation Inc., Lehman Sanctuary, Mount Lebanon Nature Conservancy, Nature Conservancy, New River Conservancy, North Branch Land Trust, Pennsylvania Resources Council, Pittsburgh Botanic Garden, River Action Inc., Sacramento Splash, Stroud Water Research Center Inc., Tatums Garden Foundation Inc., Tennessee River Gorge Trust Inc., Tippecanoe County Partnership for Water Quality, Towson University, Watershed Coalition of the Lehigh Valley, Waterways, West Virginia Land Trust Inc., Western Pennsylvania Conservancy, Whitwell Elementary School and Woodford Cedar Run Wildlife Refuge.
Due to the volume of grant applications received, each application was evaluated on a competitive basis as we strive to fund programs with a strong impact and measurable outcomes within our funding priorities.
Learn more about the American Water Charitable Foundation and the 2022 Keep Communities Flowing Grant Program, including grant opportunities focused on Workforce Readiness and STEM Education here.

domain: geography


text:
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domain: library


text:
10 February 2006 | Jane Pickard
Outsourcing HR may not deliver the predicted savings, concluded experts at a roundtable organised by SM's sister publication People Management.
Philip Vernon, principal at Mercer Human Resource Consulting, described how he warned HR directors: "If you want to save 20 per cent this year, outsourcing may not be the quickest and best way to get there."
In a large organisation, HR may represent only three per cent of total costs. "If you are talking about saving 20 per cent of three per cent, with the risks involved, there may be better prizes to be had for the chief executive and finance director," he added.
Marika Whitfield, HR outsourcing business manager at Northgate HR Outsourcing, told the roundtable that potential clients are now more interested in measures that add value rather than those saving costs.
And Debbie Sallis, HR director for Combat Air Defence Systems at BAE Systems, said her company's support for outsourcing, through a joint venture with business process outsourcing company Xchanging, was now about effectiveness rather than efficiency, although cost drove the business agenda at the start.
"I can tell my board the skills changes we are planning up to 2020. No one wants to know how I'm going to cut costs," she said.
But Vernon said he felt cost-cutting was still the main reason why organisations were interested in outsourcing. People were talking about service quality only because expected savings hadn't materialised, he said.
The debate reflects a recent survey by the Shared Services and Business Process Outsourcing Association that showed cost saving was no longer given as the main reason for outsourcing HR.

domain: finance


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Thank you for your comments. Words matter. :)

domain: game


CerdaHome® collection is a combination of tradition and innovation. 50 years’ experience and young design team are the main pillars of premium quality upholstery textiles.
Composition: Viscose, PES, Cotton, Chenille, Acrylic, Linen.
+ 40 colors
-Best raw materials
-HydroClean®, cleaning just with water


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Fruit and vegetables have always done big business but fashions and tastes change, just look at pomegranates. It used to be that whatever the hottest TV chef was cooking with would fly off the shelves now it is the health gurus. Pomegranate juice is a. ..
Seven million people in the United States suffer from Obsessive Compulsive Disorder (OCD). OCD is a complex anxiety-based disorder which has two elements to it, obsessions and compulsions. Unfortunately for some, the symptoms experienced do not end. ..
Conventional wisdom, scientific fact and various diet guru’s have allocated approximately 3 500 calories to a pound of body weight. When embarking on a weight loss program for example, one would have to consume 3 500 less calories than is usually. ..


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It appears that Israelis who received a third dose of the Corona vaccine from the Pfizer vaccine are much better protected from infection and serious diseases than people who received two injections, according to research conducted by vaccination experts on behalf of the Israeli Ministry of Health.
In people over the age of sixty, protection was significantly higher at ten days after the third dose than after two doses. Israel began giving the third vaccination to people over 60 years of age on July 30. This age group is particularly vulnerable to the coronavirus and therefore was the first to be vaccinated when the vaccination campaign began. The third dose is given only to people who received the second injection at least five months ago.
In many parts of the world, there is talk of a so-called booster vaccination. British research shows that the Pfizer vaccine works less against the Delta type of coronavirus than previously thought. Therefore, it may be desirable to receive a third blow from Corona in the winter, say more and more experts. The Dutch Health Council will issue an advisory report next month.
The World Health Organization previously advised against the third vaccination in rich countries, as long as there is still a shortage of vaccines around the world.
“Infuriatingly humble social media buff. Twitter advocate. Writer. Internet nerd.”

domain: news


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Softwares: Daz Studio 4
License: This is licensed for non-commercial use only.
This is Loki's helm, modeled after the version he wore in Thor: Ragnarok, modeled in Blender. It's smart-propped to G3M's or G8M's head. Iray and 3DL versions included, images used for the texture painted by me.
Compatible with DS4+. Not Tested in Poser or on a Mac.
Extract to your My Library folder. And please let me know if you have any issues.
Licensed for non-commercial use ONLY. Contents of this zip are not allowed to be redistributed.

domain: artistic


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On the setting button, you can set the speed of the turntable to slow down in the next round of the specific round when the player has played a certain number of rounds, which will reduce the difficulty of the game.
If the player is not yet get the capsule egg, the speed of the turntable will slow down again in the next round.
By analogy, the speed of the turntable is slowed down step by step, and the speed has been reduced to the lowest level after the fifth round, and then the speed is kept unchanged;
Until the next game after the player has got a reward, the speed of the turntable will immediately return to the highest speed, which will increase the difficulty of the game.
After the coin is inserted, press the start button to enter the game.
The ball exits from the ball mouth and slides on the two catchers.
Move thepolesto the left and right to control the front, rear, left and right direction of the ball.
In the specified time, the ball successfully fell into the turntable to get a capsule egg, or slid into the front holes to get some tickets.
Function setting button operation method
In standby mode, press the “Set” button to enter the function settings and press again to exit the settings.
In the setting mode, press the “Page” button to cycle through the selection item number. (P01-P07setting item cyclicincrement key. See the table below)
Press the “+” and “-” buttonto change the setting item function parameter value. (Range value cyclic increment key. See the table below)
Function settings table)
Number of coins per game
When the player reaches a certain number of rounds, the turntable speed starts to slow down.
Number of lottery tickets on the left side of the hole
Number of lottery tickets in the middle hole
Number of lottery tickets on the right side of the hole
Power-down memory(0: clear 1: memory)
2022 Best Ball Drop Arcade Machine For Sale|China Arcade Ticket Games For Sale


The project had two objectives. The immediate objective of the project was to support Taxiway A extension. The larger objective in the project was to use the results of the Pond Design Criteria Study to improve water quality using design features consistent with FAA guidance on minimizing Hazardous Wildlife Attractants
The Taxiway A extension enhances airport safety and operations by limiting or removing the need to cross an active runway to access the Runway 23 threshold.
The water management system improvements included master drainage planning, pre-project and post-project water quality monitoring, including 200 acres of off-site drainage through the airport’s pond system, pre-project and post-project wildlife monitoring, site specific Computational Fluid Dynamics (CFD) modeling, system improvement design, permitting with the jurisdictional agencies, construction of crenellations/baffles in existing ponds, design and construction of automated monitoring systems for water quality and quantity, coordination with stakeholders including FAA, FDOT, the Florida Department of Environmental Protection (FDEP), and the five Water Management Districts (WMDs).
The enhanced water management system also benefits the City of Naples and Collier County. Stormwater flowing from the airport eventually makes its way to Rock Creek which flows into the Gordon River then along the Naples Bay and eventually into the Gulf of Mexico.
EG Solutions’ personnel was the Engineer of Record. The project received the 2015 GA Airport J. Bryan Cooper Environmental Award from the FAC.
|Project||Taxiway A and Water Management System Improvement, Planning Design and Construction|
|Client||Naples Municipal Airport|


In the ever-evolving landscape of hip-hop and rap, one artist has emerged as a true force to be reckoned with. Dreemy Alpha, a seasoned artist, executive producer, director, and graphic designer, is taking the industry by storm, captivating audiences with his multifaceted talents. With the release of his brand-new single, ‘Ooh,’ Dreemy Alpha continues to solidify his position as an artist on the rise.
From the very first beat of ‘Ooh,’ it becomes evident that Dreemy Alpha’s artistic journey is an intriguing one. The track exudes an infectious energy and boasts a production that demands attention. It’s a feel-good offering with anthemic soundscapes, infused with the essence of rap and hip-hop. The song’s vibrant and bouncy atmosphere is accompanied by Dreemy Alpha’s confident and boastful rhyming patterns, further cementing his unique style.
Hailing from the DMV (District of Columbia, Maryland, and Virginia), Dreemy Alpha has spent years honing his craft, navigating the industry behind the scenes while building his own brand. His skills as a graphic and cinematography expert have been instrumental in creating a distinct visual identity for his music. As his music spread through sets and studios, influential figures such as DMV Hometown Heroes, including Fat Trel, 3ohBlack, and WillThaRapper, recognized his potential and encouraged him to pursue his music career seriously.
The impact of Dreemy Alpha’s talent and dedication quickly became apparent when his debut single, ‘K.I.L.L.A,’ soared to the impressive position of #40 on the iTunes charts. The accompanying album, ‘ReLOADN,’ also made a splash, debuting at #13 on the charts. This early success garnered the attention and support of industry legends like T-Pain, who took to Twitch and Twitter to express their excitement and admiration for Dreemy Alpha’s hit record.
Since then, Dreemy Alpha’s star has continued to rise, propelling him into the ranks of touring artists with a constant presence on radio airwaves. His captivating performances and infectious music have gained him a growing fan base, solidifying his status as a household name in the making.
As Dreemy Alpha’s career reaches new heights, it is evident that his artistic journey is far from over. With his versatile skill set and undeniable talent, he is poised to leave an indelible mark on the hip-hop and rap industry. Fans and critics alike eagerly await his future releases, ready to embrace the next chapter in the evolution of Dreemy Alpha.
“‘Ooh’ is a dope confident party song. The track honestly came together organically. When I heard the beat I just went into the booth and just felt like saying ‘Ooh!’ Everything else just fell into place melodically.” – Dreemy Alpha comments on the track.


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whip poor will
featuring performances from Ryan Adams & Laura Marling (both of whom he has produced) as well as Jeremy Stacey, Danny Thompson & Melvin Duffy, this is a gorgeous introduction to the singer/songwriter work of the famed producer.
his debut singer recalls willy mason, micah p hinson, ryan adams & elliott smith & features cover art by Paul Rafferty. ‘Whip Poor Will’ is the first release on the artist’s own Three Crows Records label & is taken from his forthcoming debut solo album ‘If Not Now Then When?’. the B-side is exclusive to this 7” single.
- Whip Poor Will
- The Whip Poor Will’s Lament


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We're really glad that right now we could return to multiple new and beloved categories of games for girls on our website, such as Disney Princesses Games, Baby Games, and Frozen Games, and that is possible through the really great and fun game called Princesses Caring For Baby Princesses, where Anna and Elsa are going to take the role of babysitters for Jasmine and Cinderella, who are babies in this game, and like all babies, they need someone to take care of. Anna takes care of Jasmine, while Elsa of Cinderella. How? Let us tell you all about it right here and now! Well, you are going to start by dressing up each of the two sisters from Frozen, going through the wardrobe of clothes, accessories, and haircuts, and picking a really great look for each of them. What you will do next is to feed the babies, and then wash them, finally also getting to dress them up in cute outfits. For the feeding and washing parts of the game, follow on-screen instructions, clicking where you are shown in order to do everything right. Enjoy this game, and stick around, since more great content is on its way right now!
How to play?
Use the mouse.
⭐ Games like Princesses Caring For Baby Princesses


In accordance with the Governor's current guidelines due to the COVID-19 outbreak, we have had to postpone this event; we are in the process of rescheduling. In the meantime, we can support these wonderful musicians by considering following the link below to purchase their music.
We thank you for your patience during this unsettled time. Be safe and well, friends!
Peter Seymour, double bass
Greg Pattillo, flute
Eric Stephenson, cello
PROJECT Trio is a passionate, high energy chamber music ensemble comprised of three virtuosic composer/performers from Brooklyn, New York. Blending their classical training with an eclectic taste in musical styles, they make an impact on audiences of all ages. With the energy of rock stars, PROJECT Trio is breaking down traditional ideas of chamber music and is acclaimed by the press as “packed with musicianship, joy and surprise” and “exciting a new generation of listeners about the joys of classical and jazz music.” Busting onto the scene with their landmark videos, right out of the internet generation, PROJECT Trio is a musical experience defining a new level of entertainment and is a musical experience not to be missed!
Project Trio is represented by Cadenza Artists LLC
For advance ticket sales, click here.
Cash, check, or credit card accepted at the door.
Please note that ALL seating is first come, first served. Doors open 1/2 hour before start of event.


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- Computex 2019 International Press Conference & AMD..
- Intel Announced New Portfolio for Data-Centric Era
The 24th Busan International Film Festival will hold Community BIFF 2019 from October 4th to 10th in the suburban area(old town area) of Jung-gu. Community BIFF is a spin-off film festival created by audiences and represents a special film ..
Friday, September 20, 2019, 3:28 pm
The 24th Busan International Film Festival reveals 6 Open Cinema selections which to be screened at the BIFF Theater located in Busan Cinema Center from October 4th to 11th. Open Cinema, one of the submission categories presented by Busan I..
Tuesday, September 17, 2019, 3:12 pm
Forum BIFF 2019 founded by the Jiseok Film Institute will make a beginning at the 24th Busan International Film Festival. The Jiseok Film Institute, named after the former associate film festival director, the late Kim Jiseok, is establishe..
Wednesday, September 11, 2019, 2:39 pm
The 24th Busan International Film Festival finalized the selection of 14 films for the New Currents Award, the competition section for Asian films. 14 Competition Features of New Asian Talents The New Currents Award is given to two feat..
Tuesday, September 10, 2019, 2:44 pm
The 24th Busan International Film Festival selects highly-acclaimed Japanese film director Kore-eda Hirokazu as the recipient of the Asian Filmmaker of the Year Award. The Asian Filmmaker of the Year is presented annually to a notable film ..
Monday, September 9, 2019, 3:43 pm


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Buy American Visitors Insurance Travel Health Plan: Visitors Insurance
American Travel Insurance is designed to protect the traveler from any unexpected events or mishaps that may lead to financial loss and even cutting down the trip.
Students studying abroad, business travelers, families with children, elders must take travel insurance when abroad or visiting the USA. Visitors Insurance provides an easy solution wherein we guide our clients with the absolute insurance policy that suits their requirements.
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domain: travel


iCEE Dynamics EOC
Manufacturing Process Cooling
It is critical in manufacturing production, where cooling is required, to manage and accurately & consistently achieve temperature control. ICEE’s Manufacturing Process Cooling is yet another add-on extension of the Automated Energy Opimisation feature having the ability to specifically tailor turnkey temperature controls to meet your exact needs. Whether it is a new facility or an existing one, ICEE’s MPC module is able to optimise your process cooling plant to maximise efficiency and boost productivity.