Found April 15, 2012 on
The 6th Sens:
New Jersey Devils
New York Rangers
The wrath of Brendan Shanahan has been felt. New York Rangers forward Carl Hagelin has been suspended by the NHL for three games for elbowing Daniel Alfredsson in the head and that Senators defenceman Matt Carkner has been suspended one game for repeatedly punching Brian Boyle in the face his tremendous *********** of Brian Boyle. Of course, thanks to the whimsical nature of the NHL's disciplinary decisions, no one was entirely confident in what kinds of punishment, if any, would be handed out to either of the aforementioned players.But now that the decisions have been rendered, we can dissect what each of these mean to either club. When Paul MacLean's Pete DeBoer'esque starting lineup was announced as Matt Carkner, Jared Cowen, Zenon Konopka, Chris Neil and Zack Smith, the message was clear: if you take liberties with Erik Karlsson or another one of our elite players, you're going to have your face caved in. We can endlessly debate whether we're celebrating Cark...
BEST OF MAXIM
Carl Hagelin says he is sorry for elbowing Daniel Alfredsson in the head, and knocking the Ottawa captain out of Game 2 and perhaps longer. Now the New York Rangers rookie is waiting to find out if he will be shelved, too.
Hagelin had a phone hearing with the NHL on Sunday, while his team practiced after Saturday night's 3-2 overtime loss to the Senators. He already served a...
Pat Leonard of the Daily News reports that Carl Hagelin had his hearing with the NHL at 1:30 p.m. A decision is expected later today....there better not be a suspension. Although I am fully expecting one.Meanwhile, all the healthy players were at practice execpt for Henrik Lundqvist who was given the day off.With Hagelin at the hearing Fedotenko skated with Richards and Gaborik,...
Afterall, Brendan Shanahan has been a part of the Wings locker room and he knows the main goal of that room is to win the game.
Instead of suspending Shea Weber for a game, maybe Shanahan knew/felt the Wings would respond in a way to make Weber accountable for his actions and still force Weber to skate on egg shells for the rest of series.
Back in his Detroit playing days, Shanahan...
The National Hockey League has suspended New York Rangers forward Carl Hagelin for three games for his elbow to the head of Daniel Alfredsson in the second period of Saturday's Game 2 against the Ottawa Senators at Madison Square Garden. Hagelin had a hearing with VP of player safety Brendan Shanahan earlier this afternoon.
According to the rulebook and the rulebook alone, yes...
Just moments into tonight's game at Madison Square Garden, Senators defenseman Matt Carkner started a melee with Rangers forward Brian Boyle. The Senators put Carkner (best known for his fighting) into the starting lineup, signalling something was up.Carkner, who didn't play in Game 1, sucker-punched Boyle to set off the fireworks at the 2:15 mark of the first period. Carkner...
Matt Carkner has been suspended one game for his actions in the second game of the Ottawa / New York series. That sound you might hear is thousands, if not millions, of NHL fans laughing and mocking at how once again the NHL discipline department has missed the mark.
One game? Seriously? Did they actually mean one game per punch landed by Carkner...
Just 2:15 into Game Two between the New York Rangers and Ottawa Senators, Matt Carkner got hockey fans buzzing. Carkner went after Brian Boyle and sucker punched him in the face. Boyle went down, and Carkner continued punching him in the face. Carkner got a game miscounduct and so did Brandon Dubinsky. The Senators ended up winning the game in OT thanks to a goal by Chris Neil.Carkner...
Brendan Shanahan had a busy regular season, but he could be in line for a busier postseason. Three players will have hearings with the league disciplinarian for their actions during Saturday's slate of playoff games. Rangers forward Carl Hagelin and Senators defenseman Matt Carkner will each have hearings Sunday afternoon, while Blackhawks forward Andrew Shaw will have a hearing...
It is only the first round of the playoffs. Competition heats up as play goes on. But considering the level of intensity that has already been achieved, what on earth do the next rounds have in store?Chief disciplinarian, Brendan Shanahan, has been busy in the first week of the playoffs. He has handed out four suspensions and four fines to players and teams. Boarding, elbowing...
Daniel Alfredsson has confirmed he sustained a concussion in Game 2 of Ottawa's playoff series with New York when Rangers forward Carl Hagelin elbowed him in the head.
However, the Senators captain participated in Monday's morning skate and said he's a game-time decision for Game 3 at night.
Alfredsson missed more than half of Ottawa's series-tying victory Saturday...
Player safety? No, silly. When a player gets his brains scrambled, the NHL gets a rivalry. Rivalries are easy to promote and things that are easy to promote bring in big bucks. The NHL loves and needs big bucks.So what makes Bettman, Shanahan and the rest of the NHL front office slugs nervous?
The media.When Savard got rocked by Matt Cooke, there were some angry fans out there...
There's been a large to-do recently about discipline in the NHL, from Shea Weber's fine to Matt Carkner and Carl Haglen's suspensions. There's no consistency in discipline, especially when so much of it is based off of whether someone is injured or not. There's no punishing the intent, rather, there's punishing of the outcome.
The intent here was to embarrass...
Alfredsson has not returned to the game.


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Conferences - Seminars
12:15-13:15 GR A3 32
Abstract: Low-order streams form the most abundant and the largest component of fluvial networks. They transport and process particulate and dissolved substances of terrestrial or anthropogenic origin. For example, they can be strong sources of the atmospheric greenhouse gases CO2, CH4 and N2O, or they convert anthropogenic nitrate loads into N2. The type and magnitude ... Read more about "EESS talk on "Hydrodynamic control of biogeochemical cycling in streams""

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Digital imaging is one of the most effective methods of diagnosing a pet's medical issues. At Intermountain Pet Hospital, our state-of-the-art equipment enables us to get timely and accurate information on animals' physical health. Examples of digital imaging include:
Digital imaging allows us to diagnose a wide variety of conditions such as:
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Saving copies also allows us to send images to various specialists for same-day second opinions. This helps further ensure that we choose the right treatment options for your pets.
To keep our imaging services affordable, we offer them at our hospital locations.
As a full-service veterinary facility, Intermountain Pet Hospital offers a complete array of diagnostic tools. Because so many factors can affect an animal’s health, proper diagnosis is essential to effectively managing your pet’s condition.
While our doctors can detect several issues with a complete physical exam, they can't see what may be going on inside your pet. Because emergency situations require fast lab results, we've invested in a complete in-house laboratory diagnostic testing system. This system allows us to get immediate results and begin treatments quickly. This can make the difference between saving your pet's life and losing it. This technology is available at both our main hospital and our satellite location.
Our on-site laboratory allows us to obtain rapid results, so you don’t have an unnecessary wait or delay in your pet’s care, and we can begin treatment as quickly as possible. On-site services include:
Some conditions may require advanced laboratory testing. Intermountain has partnered with Idexx veterinary laboratory services to make this available, convenient, and affordable for our patients. In most cases, we have a turnaround of 24 hours for lab results.
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-- Roz Kaveney, contributor to the Times literary supplement
"A slick dark SF thriller as terrifying as the silence between the stars"
-- Roz Kaverny, contributor to The Times Literary Supplement
Isolated by society, he is thrown a lifeline by the one person who might believe his story. On one condition: return to the derelict. He is offered the chance of redemption and to confront his demons but in the process he must face the horrors that took his world from him.


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Wednesday, July 25, 2018
The Refusers - Disobey
The Refusers are lead vocalist and guitarist, Michael Belkin, Eric Robert on keyboard, drummer Brendan Hill and bassist/vocalist Steve Newton. This band is amazing. Their song Disobey, is a mid-tempo, head bobbing beauty. Their music makes you want to rebel, to go against anything that you do not believe in. You should stand up for yourself! I absolutely love music like this. The song has solid vocals, great guitar, excellent drums and it is mixed very well. Blast it in your car, it will actually motivate you. Check out their website at www.therefusersepk.com


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NEW YORK – CareDx reported after the close of the market on Thursday that its third quarter revenues rose 58 percent year over year, thanks largely to a 61 percent increase in testing services revenues.
For the three months ended Sept. 30, the molecular diagnostics company reported total revenues of $53.4 million, up from $33.8 million during the same period a year earlier, edging out the average Wall Street estimate of $53.0 million and its own preliminary Q3 revenue report of $53 million from earlier this month.
Testing services revenues rose to $45.5 million from $28.2 million in the prior-year quarter, while product revenues rose 29 percent to $5.4 million from $4.2 million. Digital and other revenues rose 79 percent to $2.5 million from $1.4 million in Q3 2019.
Separately, CareDx also announced that current Chairman and CEO Peter Maag will assume the role of executive chairman of the board, effective Nov. 1, and that current President and Chief Business Officer (CBO) Reginald Seeto will take over as president and CEO. Seeto will also join the firm's board.
Maag joined CareDx in 2012 as CEO and led the company through its IPO. Seeto joined CareDx in 2018 as president and CBO, leading the company's commercial, clinical, manufacturing, and R&D organizations.
"Our team continues to deliver the winning formula for CareDx. Beginning with a decision to drive our initiatives with a singular focus on transplantation, we continue to execute on our objectives and achieve tremendous results as we march forward with our mission to improve transplant patient care," Maag said in a statement. "We truly have an imminent opportunity to make our solutions be the standard of care for transplanted organ surveillance, and our efforts are centered on making this a reality."
CareDx said it returned more than 21,800 patient results from its AlloSure Kidney blood-based, donor-derived, cell-free DNA test for organ transplant rejection and AlloMap Heart transplant test to patients in Q3. On a conference call with analysts following the release of the earnings, Seeto noted that this was a 65 percent year-over-year increase.
He also said that around 150 transplant centers are offering the RemoTraC mobile phlebotomy service to their patients, and that more than 5,000 kidney, heart, and lung transplant patients have enrolled in the program to date. CareDx launched RemoTraC in early April to provide blood draws of routine transplant tests at home.
Further, Seeto said, while product revenues rose during the quarter, that business has been "negatively impacted by the global pandemic because hospitals and transplant laboratories across the US and Europe continue to restrict access to their facilities for some non-essential personnel."
The firm's Q3 net loss widened to $2.8 million, or $.06 per share, from $1.8 million, or $.04 per share, in Q3 2019. On an adjusted basis, the company reported earnings of $.10 per share for the quarter, beating analysts' consensus expectation for a loss of $.06 per share.
CareDx's Q3 R&D costs rose 47 percent to $12.5 million from $8.5 million in the year-ago quarter, and its SG&A expenses rose 31 percent to $27.0 million from $20.6 million.
The company ended the quarter with $213.8 million in cash and cash equivalents.
CareDx said that while it experienced improved trends in the third quarter, it won't be providing guidance because of the continued uncertainties with respect to the COVID-19 pandemic.

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text: Sure, between the Federal Reserve and Congress $180 Billion of future taxpayers' wealth might have been wasted on AIG in two bailouts. Sure, untold tens of billions of dollars of that passed right through AIG and went to banks in Europe and Asia. Sure, these coordinated actions by Congress and the Fed has propped up zombie banks that destroy untold billions more wealth. But Congress is going to tax the bonuses on people work for AIG Financial Products, and make more than $250,000 per year, at 90%. If this action isn't challenged and ruled unconstitutional, they are going to get back 90% of some portion of the $170 Million in bonuses that represents less than 1/10 of 1 percent of the money that they've wasted on that one company this year. Good thing they're looking out for us and our children.

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In recent years, the antiviral medication Tamiflu has been put forward as a crucial tool in the battle against influenza, particularly for the elderly who are at higher risk for serious complications. The spotlight on Tamiflu stems from its claimed ability to reduce the severity and duration of flu symptoms when taken shortly after onset. For seniors, whose immune systems are often compromised due to age and other conditions, Tamiflu promises not just symptomatic relief but also a buffer against potentially life-threatening flu-related complications, such as pneumonia and bronchitis.
The significance of Tamiflu for older adults goes beyond mere symptom management; it represents hope for maintaining quality of life during flu season. As the elderly population continues to grow, healthcare systems worldwide are seeking effective strategies to safeguard this vulnerable group. Here, Tamiflu is positioned as a key player, offering a defense mechanism that could bridge the gap between catching the flu and enduring a possibly perilous illness, making it an intriguing topic of discussion among healthcare professionals and the elderly community alike.
Delving into the Efficacy of Tamiflu for Seniors
Tamiflu, generically known as oseltamivir, has been a subject of interest in geriatric medicine due to its potential in mitigating the severity of influenza symptoms. Studies have shown that when administered within 48 hours of symptom onset, Tamiflu can reduce the duration of the illness in seniors, a population particularly vulnerable to the complications of flu. The efficacy in the elderly is underlined by their amplified need for preventative care, as the immune response to influenza can lead to more serious conditions, such as pneumonia, that can escalate into hospitalization or even become life-threatening.
However, while clinical trials generally support the positive impact of Tamiflu in reducing complications, the results are not unequivocal. The degree of its effectiveness hinges on several factors, including the patient's overall health, pre-existing conditions, and the timing of administration relative to the onset of flu symptoms. The presence of comorbidities common in aged populations can influence the therapeutic outcomes, necessitating a nuanced understanding of Tamiflu's role in elderly patient care. Despite some variation in outcomes, the consensus tilts towards Tamiflu being beneficial for the elderly if used appropriately, bringing to the fore the importance of individualized patient assessment for optimal results.
The Potential Dangers: Side Effects in Elderly Patients
While Tamiflu (oseltamivir phosphate) is considered a frontline defense against the flu, it is important to recognize that elderly patients might be more susceptible to its side effects. Common adverse effects such as nausea, vomiting, and headaches could manifest more intensely in older adults, who may already have a diminished capacity to deal with additional stresses to their systems. More serious concerns include neuropsychiatric events and the risk of sudden confusion or delirium, which could lead to potentially dangerous situations, especially in those with preexisting cognitive impairments.
Careful monitoring is essential as the risk of renal impairment—a side effect of Tamiflu—may be heightened in the elderly due to the natural decline in kidney function associated with aging. Health professionals need to be vigilant about dose adjustment and be aware of the potential for drug interactions with existing medications. It's imperative to balance the drug's ability to reduce flu symptoms and duration with the possibility of reduced drug clearance, and increased exposure to side effects that can compromise an elderly patient's health and recovery prospects.
Balancing Act: Weighing Benefits Against Possible Risks
The decision to administer Tamiflu (oseltamivir phosphate) to the elderly must consider the medication's ability to reduce the duration of flu symptoms and potential complications against the backdrop of a higher susceptibility to side effects. In senior populations, the urgency of early treatment is paramount, as they are more likely to experience severe influenza outcomes, including hospitalization and pneumonia. However, the geriatric demographic is also more prone to adverse drug reactions due to factors like multiple medications, comorbidities, and age-related physiological changes.
Healthcare providers face the delicate choice of leveraging Tamiflu's benefits, such as shortened illness span and curtailed spread of the virus, while remaining cognizant of its possible adverse reactions, like nausea, vomiting, and in rarer cases, neuropsychiatric events. The risk-benefit analysis is further complicated by the timing of antiviral intervention; benefits are most significant when treatment begins within 48 hours of symptom onset. This narrow window presses clinicians to make judicious use of Tamiflu, optimizing its advantages for elderly patients while minimizing potential harm.
Tamiflu in Real World Scenarios: Elderly Success Stories
Documented cases reveal that when administered promptly during influenza infection, Tamiflu has significantly reduced complications in the elderly, leading to swift recovery from the severity of flu symptoms. Success stories often emphasize fewer hospitalizations, reduced pneumonia cases, and a quicker return to baseline health, reinforcing the medication's strategic role in managing seasonal outbreaks among older populations.
In particular, nursing home reports where influenza can spread rapidly and prove fatal underscore the benefits of Tamiflu. Controlled studies have shown that early Tamiflu administration not only decreased the duration of the illness but also possibly prevented the spread among the high-risk community, highlighting the drug's potential in made-to-scale public health strategies for the elderly.
Navigating the Decision: When Should Elders Take Tamiflu?
Deciding if and when an elderly person should take Tamiflu is a complex process that involves a careful assessment of their overall health status, the severity of the flu symptoms, and the timing of the onset of these symptoms. It's generally recommended for elders to start Tamiflu within 48 hours of flu symptom onset, as it is believed to be most effective during this window. However, for those residing in nursing homes or who have chronic health conditions, the decision may lean more favorably toward treatment, even if the 48-hour window has passed, given the higher risks they face from influenza complications.
Healthcare providers also take into account the prevalence of flu in the community and the strain of influenza when advising elderly patients. If the circulating virus is known to cause severe illness, or if an epidemic is declared, doctors might be more inclined to prescribe Tamiflu as a preventive measure for those not yet affected but at high risk. Elderly individuals with compromised immune systems or multiple health issues may benefit from such prophylaxis. Ultimately, the decision to use Tamiflu should be made in close consultation with a healthcare professional, considering both the individual's specific health risks and the known benefits and potential side effects of the medication.
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Revitalizing Skin: Potential of Stem Cells in Dermatology and Anti-Aging
Since the discovery of multipotent stem cells in 1961, their functions have been recognized in developing new cells and maintaining the balance of normal cells. Stem cells have been utilized in various medical applications and play a significant role in understanding aging and age-related issues, as DNA damage and the decline of endogenous stem cells are key factors in the aging process. There are different types of stem cells, including pluripotent cells, unipotent progenitors, and various birth-associated stem cells. While these stem cell types offer potential for treating aging and age-related diseases, they also have limitations and ethical concerns.
Alternative approaches, such as modulating endogenous stem cell populations using pharmaceuticals, are being explored. Advances in regenerative medicine provide opportunities to target individual stem cells for addressing age-related dysfunctions like skin aging.
In this blog, the potential of Lgr6+ cells and defensins to reverse the signs of skin aging will be explored.
Types of Dermatological Stem Cells
The regulation of skin stem cells for the purpose of repairing aged skin have been the subject of extensive research. Studies involving wound healing and genetic manipulations have revealed various populations of stem cells in the skin with potential applications in regenerative medicine. Basal epidermal stem cells play a crucial role in maintaining the turnover and balance of the epidermis, while hair follicle stem cells are involved in transient skin wound repair. Different types of follicular-based stem cells, such as Lrig1+, Gli1+, and Lgr6+ cells, contribute to specific components of the hair follicle and the overall skin structure.
These stem cells are capable of multi-lineage contributions and exhibit resilience to aging-related damage. This resilience has sparked interest in further investigations to explore their regenerative capabilities.
1. Epidermal Stem Cells
The stratum basale of the epidermis contains basal cells that serve as stem cells for maintaining epidermal homeostasis. The precise mechanisms of their proliferation are still being studied, and two main models have been proposed. The first model, known as the epidermal proliferative unit model, suggests that a single basal cell is responsible for self-renewal and proliferation within a specific unit. According to this model, the entire epidermis is composed of multiple units, each characterized by the presence of a single basal cell. In contrast, the Committed Progenitor model proposes that basal cells divide randomly, giving rise to either two differentiated daughter cells, additional basal cells, or a combination of both. To reconcile these two models, a third model has been proposed, integrating aspects of both. This model suggests that the coexistence of these two modes of division allows for the maintenance of the epidermis under normal conditions and also facilitates wound healing when necessary. Further research is needed to fully understand the mechanisms and significance of these different modes of division in epidermal stem cells.
2. Hair Follicle Stem Cells
Hair follicles house a significant population of stem cells that play essential roles in hair cycling, sebaceous gland maintenance, and wound healing. These stem cells exhibit distinct marker expressions, such as Shh, Sox9, K15, Lhx2, Lrig1+, and Lgr6+. Bulge cells, located in the hair follicle bulge region and positive for K15 expression, are slow-cycling stem cells that can participate in anagen hair follicle cycling and temporarily contribute to interfollicular epidermis regeneration after injury. Lrig1+ cells, found in the junctional zone above the bulge, maintain the infundibulum and sebaceous gland structures. They can also contribute to wound healing by producing epidermally fated clones. Lgr6+ cells, located above the hair bulge, are unlike other populations that normally maintain one aspect of dermatologic homeostasis. They are multipotent stem cells that can replenish both the epidermis and sebaceous gland under normal conditions. During wound healing, Lgr6+ cells are involved in long-lasting repair of the epidermis. These different populations of hair follicle stem cells demonstrate specialized functions in both homeostasis and regeneration processes of the skin.
3. Sebaceous and Sweat Gland Stem Cells
The sebaceous and sweat glands are skin appendages that serve important functions in maintaining skin health. Sweat glands contribute to thermoregulation, excretion, and immune function, while sebaceous glands lubricate the skin. The sweat gland contains suprabasal progenitor cells that are capable of generating sweat-producing luminal cells. Additionally, ductal cells within the sweat gland are responsible for maintaining the openings of the ducts on the skin and can participate in the regeneration of the surrounding epidermis following tissue injury. In sebaceous glands, Blimp1+ cells are responsible for producing sebocyte progenitors, which are the cells that give rise to sebocytes, the main cells of the sebaceous glands.
Aging is characterized by the decline of physiological functions, which can be attributed to various factors such as genomic alterations, decreased telomere length, protein and cellular damage, increased inflammation, cell senescence, exhaustion of endogenous stem cells, and impaired intercellular communication. While these mechanisms can contribute to the aging process, they can also be involved in beneficial repair mechanisms that ultimately become detrimental and compromise tissue integrity.
Skin aging is influenced by factors like UV damage, environmental insults, inflammation, and oxidative stress. These lead to the deterioration of epidermal and dermal tissues, loss of collagen and elastin, decreased epidermal thickness, and reduced growth factors in the skin.
The healing of wounds and the aging process share similarities in genetic and cellular pathways, but adult skin healing is associated with scar formation and altered skin composition, unlike scarless fetal skin repair. Understanding the mechanisms involved in fetal wound healing offers insights into potential strategies to reverse or delay skin aging. Mesenchymal stem cells derived from the placenta or umbilical cord, as well as the use of growth factors to induce keratinocyte and collagen proliferation, have shown promise in skin aging therapies.
However, there is a need for further research to determine the necessary components, address safety concerns, and improve treatment specificity. Current approaches, such as using plant stem cell extracts or conditioned medium growth factors, have limitations in terms of efficacy, specificity, and potential risks, including tumorigenesis. The use of well-defined growth factors offers greater control, but nonspecificity and activation limited to aged skin cells remain challenges. Standardization of growth factor products and a better understanding of their effects are also needed for more effective skin aging treatments.
Applications of Lgr6+ Stem Cells & Defensins
Lgr6+ cells, as mentioned previously, are multipotent cells located in the hair follicle above the bulge that actively contribute to both the epidermis and sebaceous gland. Their expression begins during embryonic development and continues throughout hair development, eventually becoming restricted to the central isthmus above the hair bulge in adult skin. These cells are considered primitive epidermal stem cells due to their role in establishing the epithelial placode and their multipotency in adult skin. Transplantation studies and lineage tracing experiments have confirmed their ability to form all skin lineages and aid in long-term wound healing. Lgr6+ cells are of particular interest in the study of skin aging and regeneration, as they migrate to the wound center and participate in reepithelialization. Additionally, they have shown potential in promoting hair follicle neogenesis within wounds. Understanding the development, localization, and recruitment of Lgr6+ cells in adult hair follicles and their involvement in wound healing is important for advancing skin regeneration and addressing aging-related concerns.
Defensins are a group of antimicrobial peptides with different functions and structures from growth factors. Specifically, β-defensins, secreted by the skin epithelium, play a crucial role in Lgr6-mediated skin healing. These peptides provide innate immunity by preventing microbial colonization on the skin surface. They also enhance tight junctions and reduce the permeability of the skin, thereby preventing water loss. Moreover, β-defensins induce wound healing by recruiting Lgr6 stem cells to generate new basal stem cells and stimulate the production of keratinocytes in the wound bed. Researchers have explored the use of α-defensins, specifically intestinal α-defensins, to stimulate Lgr6 stem cells and enhance wound healing in murine skin wounds. The application of α-defensins could be particularly beneficial in large-scale wounds or burns where the local stem cell niche is compromised, and β-defensins are no longer present. Additionally, due to Lgr6's involvement in keratinocyte production and the rejuvenation of skin, α-defensins may hold potential for reversing skin aging.
Role of Lgr6+ Stem Cells & Defensins in Anti-Aging
Defensins offer a new approach to address skin aging by activating Lgr6+ stem cells specifically. This targeted approach minimizes potential side effects or tumorigenic risks associated with other treatments. Defensins have shown the ability to suppress tumor growth and are naturally involved in protective immune responses. Lgr6+ cells, residing in a UV radiation-protected area, are less likely to accumulate mutations and damage compared to basal stem cells. Activating these cells leads to the proliferation of less damaged keratinocytes.
Clinical studies have demonstrated positive outcomes with defensin-based skincare regimens, including improved wrinkle reduction, decreased skin oil production, increased epidermal thickness, and improvements in skin texture, pigmentation, and evenness. Though further research is needed, defensins provide a promising targeted therapy for skin aging.
See below the figure comparing nonspecific versus specific targeting, where the activation by growth factors is nonspecific and is based on a “switch-on of everything” mechanism, while defensins activate only 1 specific cell type in skin, Lgr61 stem cells, thus representing a target-specific activation. (From Taub, 2018)
New skin therapies are being developed to reverse signs of aging. Growth factors have been used, but they lack specificity and may activate cells not involved in rejuvenation, posing risks.
Stem cells in the hair follicle, particularly Lgr6+ cells, have shown potential in wound healing and skin regeneration. Defensins, peptides produced by the skin for immunity, can target and activate Lgr6+ cells, promoting their migration and proliferation in the wound bed. Defensins offer advantages over growth factors, as their composition is known, they specifically target Lgr6+ cells, and they activate stem cells with less genetic damage.
Pilot studies have demonstrated improved epidermal quality and comprehensive reduction of visible signs of aging with topical defensin application. This effect may be due to the repopulation of the epidermis with new and healthy basal cells, leading to enhanced dermal renewal and function.
See below the figure illustrating comprehensive improvement of signs of skin aging, with defensin-based full formula, C shows a high-resolution photograph of a participant in the full formula group at baseline, and D shows the results after 12 weeks. (From Taub, 2018)
Aging and Mesenchymal Stem Cells: Basic Concepts, Challenges and Strategies (2022)
Stem cell therapy in dermatology (2020)
Stem Cells in Dermatology and Anti-aging Care of the Skin (2018)
Stem cells in dermatology (2014)
Discover the Science behind Anti-aging Stem Cell Therapy, Tissue Engineering, Genome Editing Tools & Cell Cultures in our upcoming Anti-Aging Stem Cell & Regenerative Medicine Mini Fellowship happening globally:
IFAAS Mini Fellowship (Hands-On)
Anti-Aging Stem Cell, SVF Therapy & Regenerative Medicine
Oct 18, 2023 - Seoul, South Korea - [Register Now]
More Upcoming Aesthetic Trainings Happening Globally

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Route 331 Detour Alert
Starts Friday, July 23, 2021
Due to the temporary closure of the parking lots at the south end of the Triton College campus, Route 331 will be unable to enter the campus. As a result, buses will remain on 5th Avenue while this detour is in effect.
Buses will resume the normal routing on the campus when construction is complete which is expected to be Monday, July 26, 2021.


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GUCCI has confirmed that it will show its pre-spring/summer 2017 show at Westminster Abbey in London on June 2 this year.
Read more: How To Give Your Home The Gucci Look
"Creative director Alessandro Michele has chosen one of London's most historic and beautiful settings for his cruise 2017 fashion show: the Cloisters at Westminster Abbey," read a statement from the brand this afternoon. "Gucci will be the first fashion house to host a runway show in this historic location."
Read more: Gucci Show Coming To London
The news comes after Michele, who lived in London for years, was honoured at the British Fashion Awards in November where he picked up the International Designer Award. His chosen venue for the already hotly anticipated event has previously hosted some of the most prestigious events and royal occaisions in the world, including the wedding of the Duke and Duchess of Cambridge in 2011.
Read more: The Royal Wedding
The decision to show in the capital bucks the trend with fellow fashion houses Louis Vuitton and Chanel who have decided to show their cruise collections in Rio di Janeiro and Cuba respectively.
Read more: Louis Vuitton Heads To Rio
Read more: Karl Takes Cruise To Cuba

domain: entertainment


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[open-table-widget display_option=”0″ restaurant_id=”268411″ title=”” max_width=”1000px” align=”left” widget_style=”bare-bones” input_submit=”BOOK A TABLE”]
Located at the Four Seasons Hotel New York Downtown, CUT’s New York outpost is the chef’s first Manhattan restaurant. With its own entrance off Church Street, CUT by Wolfgang Puck is where New Yorkers broker deals over power meals, and where Tribeca’s residents come to dine, wine and unwind, while world travelers immerse themselves in downtown NYC’s emerging culinary scene.
Enjoy breakfast, lunch or dinner in the elegant and intimate atmosphere of the dining room or bar & lounge, featuring window views overlooking the bustling streets of lower Manhattan. The interior, designed by cutting-edge French designer Jacques Garcia in partnership with Kimberly Brown and STRATA Architects, is complemented by artwork curated for the space by Gelila Assefa Puck.
Located within the Four Seasons New York Hotel Downtown, CUT’s private dining room offers a warm and intimate space to host your next private gathering. Faux gold leaf wood and gilt curtains surround a wall of glass which gives guests a one-of-a-kind view of the behind-the-scenes action of the CUT kitchen. The main dining room and bar and lounge areas are also available private and semi-private events during breakfast, lunch and dinner.
Private Dining Room: 32 seated
Bar: 32 seated
Dining Room: 82 seated

domain: travel


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BOLIVIA, N.C. (AP) — While most people only think about turkeys around meals on the holidays, Maud Kelly enjoys watching them wobble on her family farm in Bolivia.
“I raised quite a bit this year and it’s the most I’ve ever raised,” she said. “It’s a crazy amount of work. They are really wacky birds. They’re fun, but they are a lot to keep up with. It’s like having 25 toddlers running around.”
Greenlands Farm, a sustainable homestead farm located in rural Brunswick County, has been in the family for three generations. They began raising birds in the 1980s before taking a hiatus. Work resumed in the early 2000s, with tours of the farm in the later years.
Kelly got into raising rare breeds such as the Heritage Midget White Turkey, which are around 8 to 12 pounds.
It’s an alternative to raising commercial birds, which takes 12 to 14 pounds to mature for processing. The heritage turkeys on Greenlands Farm take about 6 to 7 months to mature on 16 acres of land.
“There’s a lot of care and cost that goes into raising them for that long,” she said. “But the meat is definitely superb compared to a commercial turkey.”
With the Thanksgiving holiday coming up, they are ready to take orders for fresh birds − an alternative to the frozen types.
Raising turkeys is a job that comes with challenges. For Kelly, one of them is a rise of feed cost, which has gone up 15% since 2020. It cost about $2,500 every six months.
“It’s costing us twice as much to feed them, compared to when we first started,” she said about the turkeys. “I call them little pigs on two feet. My other birds don’t eat as nearly as they do.”
Kelly is picky about what they eat. When supplies are available, they try to feed them non-GMO food and high quality things.
“We humanely raise them and process them, and they get a few hugs from me here and there too,” she said. “They are really sweet birds. They are quirky little birds. Anytime I have a conversation and laugh, they laugh with me.”
As the Wilmington area continues to grow, Kelly believes turkeys will continue to have a place in the economy, especially places like the farm offering agritourism. A lot of support comes from New Hanover and Brunswick counties.
“There’s a lot of cute urban farms now,” she said. “It’s nice to see people supporting their local farms.”
But the commercial and residential growth comes with challenges, such as wildlife being displaced. To keep her birds safe from predators, she added livestock guard dogs.
“That’s been within the last three years,” she said. “Before then, I would walk out and there would be 30 birds dead from a fox. It’s heartbreaking. My birds may be breeders or raised for meat, but they are loved every day by us. I’m a little different than some people. I love my animals no matter what they’re here for. It’s devastating to see that.”
Despite the obstacles, turkey farming in the region is not going away anytime soon in the Wilmington area, especially with North Carolina being ranked second in the nation for turkey production.
According to officials from the North Carolina Poultry Association and the U.S. Poultry & Egg Association, companies that produce and process turkey are an integral part of local counties. This is done through giving supplies and materials to the industry, creating jobs, and distributions to state and federal taxes.
A 2022 economic impact study of the poultry industry by John Dunham & Associates showed the turkey industry was responsible for $44.11 million in total economic activity and created or supported a total of 225 jobs in Brunswick County.
For New Hanover, the industry was responsible for close to $122 million in economic activity with an impact on 660 jobs. The industry’s economic activity on Pender County was $21.88 million and 121 jobs.


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Gong marks World Alzheimer’s Day
With regards to World Alzheimer’s Day, VUmc Alzheimercenter opens trading. CEO and neurologist Philip Scheltens sounds the gong in the presence of doctors and researchers working at the center.
Dementia affects every 1 out of 5 people and 70% of the cases are caused by Alzheimer’s. Dementia is the disease that entails the highest costs for our society and is currently still incurable. In the Netherlands, dementia is the fastest increasing disease, adding a new patient every 15 minutes. Only scientific research can bring us closer to a solution. At VUmc Alzheimercenter research is conducted on Alzheimer’s Disease and other types of dementia, particularly at a young age, in order to find a cure for this future epidemic.
For more information: www.alzheimercentrum.nl


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Tutoriels et matériel Illustrator
Get flash to fully experience Pearltrees
Welcome to YouTube! The location filter shows you popular videos from the selected country or region on lists like Most Viewed and in search results.To change your location filter, please use the links in the footer at the bottom of the page.
If you couldn’t tell I am a big fan of the “you suck at photoshop” videos. Here is a new vector for you.
Welcome To CreateSk8.
When it comes to web and graphic design, Adobe Illustrator is usually the primary option to consider.
Photoshop stuff Vector graphics Stock images Free templates Logo and icons Android Applications
Silhouette of Beautiful Girls. Download free vector clip art silhouettes of beautiful girls in fashion style. It is so simple to modify any vector file: rotate, recolor, change size, add other elements, remove elements.
We all know how good it is to have correct clipart in a times of tight deadlines and creative block which, sooner or later, happens to all of us. And It's much more better to have them for free. That's what we doing here - sharing tons of design tools for free.
16 fun whimsical cliparts!
Ever since I was a child I have been a fan of comic books.


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Dr. Kjaer can help You and the Family with…
Dr. Kjaer, Victoria Family Chiropractor, has helped countless people in his over 25 years of practice. We have had great success in returning children, teenagers, athletes, adults, mothers and the elderly back to their normal lives: fully participating in their hobbies, sports, workplace activities and with family. We use techniques and therapies, including chiropractic, massage and physical therapy, that create results. Ultimately, it’s a simple formula: excellent individualized care on a happy and relaxed patient.
Numbness / tingling in the arms / hands
Tendonitis such as tennis elbow
Inability to do your favourite activities
Tension across the top of shoulders
Whiplash / Soft tissue injury from car accident
Hip pain or arthritis
Fatigue / low energy / stress
Carpal tunnel syndrome
Ankle sprain / Foot pain / Bunion
You may not be able to categorize your pain or limitations into one of these groups. In fact, you may not feel any symptoms or warning signs at all. If you have experienced any of the above symptoms or limitations, or have another musculo-skeletal complaint, or would like to avoid these problems in the future, there is a good chance Dr. Kjaer can help you. The only way to find out is to call our office and make an appointment.
Dr. Kjaer is happy to answer any questions you may have. Perhaps you could benefit from chiropractic care. Take this opportunity and call – it could be your first step to better health.


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Have you ever walked into a room and suddenly forgot the reason why you went in there? Do you have trouble remembering where you parked your car in a crowded parking lot? The likely answer is “yes” and we have all been there! When memory loss begins to disrupt your daily life, however, a bigger issue may be at play. Alzheimer’s is a type of brain disease that negatively affects memory, thinking, and reasoning skills. Sadly, research tells us that an estimated 5.5 million Americans age 65 and older were living with Alzheimer’s in 2018. Early detection is key to help relieve symptoms and allow you time to prepare for long-term care costs and future medical care, which is why we want to share with you five warning signs of Alzheimer’s to look out for.
- Significant memory loss
One of the first signs of Alzheimer’s is memory loss that is not simply age-related. The memory loss is so significant that it affects daily life. Examples of this include forgetting important dates and commitments, and repeatedly asking for the same information. Unfortunately, Alzheimer’s also targets concentration. If you or a loved one begin to find it particularly challenging to create and stick to a plan and solve simple daily problems that arise, it is important to evaluate the frequency and extent to which this is occurring.
- Inability to complete familiar tasks
Sometimes, people with Alzheimer’s find it difficult to complete daily and familiar tasks. Things like remembering driving directions to a common location, being unable to follow a familiar recipe, or experiencing difficulty following instructions may be warning signs. Also, take note if your loved one is withdrawing from hobbies and other social activities.
- Confusion about time and place
As we get older, it is common to forget the date for a few hours. If you or a loved one, however, are increasingly unable to remember the date, time, season, and even where you are or how you got there, this suggests a bigger problem. Another common symptom of a person with Alzheimer’s is misplacing objects or putting them in strange places. This is a symptom that tends to occur more frequently over time.
- Difficulty speaking and writing
For some people, experiencing difficulty in speaking and writing skills can be a sign of Alzheimer’s. They may stop mid-sentence, be unable to follow along in a conversation, or may begin calling objects by the wrong name. These are all important signs to look out for.
- Noticeable changes in personality
People with Alzheimer’s may experience an increase in poor judgment and decision-making skills. Common signs include neglecting their appearance or giving large amounts of money away. If this is something you notice in a loved one, we encourage you to discuss your planning options with a Florida Elder Law attorney to help protect your loved one’s belongings. The personalities of someone with Alzheimer’s may also change. You may notice an unusual increase in irritability, confusion, and frustration.
If you notice any of these signs in yourself or a loved one, do not wait to schedule an appointment with your physician. It is equally as important to discuss your long-term care needs with an experienced Florida Elder Law attorney to help prepare for increased costs. If you have any questions or are ready to begin long-term care planning, do not hesitate to get in touch with us to schedule an appointment.


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Hello there people, our most recent coloring picture which you can use with is Strawberry Shortcake Coloring Page Friendship, posted under Cartoon Coloring category. For more picture related to the picture right above you, you can surf the next Related Images section on the bottom of the webpage or simply searching by category. You may find many other entertaining coloring picture to collect. Have fun!
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Any infringement on trademarks and copyrights is unintentional and will be rectified upon notification.

domain: hobby


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Records: No. 2 MSU is 1-0.
The Blue Devils coach became the first men's Division I coach to win 1,000 games at one school as Duke defeated Utah Valley 99-69 on Saturday.
"It's just gonna be fun going against a guy like [Bagley], just because he's going to push me", Jackson said in a statement on Friday, according to Land of 10, "I've got to focus in". "Let the moment excite them".
"It's not just another game". No. 1 Duke is 2-0.
The Jayhawks are comfortable favorites entering the game, and they should be able to fend off the developing Wildcats.
Grayson Allen looks rejuvenated after struggling last season as the "point guard" of the team.
Taylor Swift's 'Reputation' sales soar, but Adele keeps her crown
Her previous opening week high came courtesy 2014's "1989", which sold 1.287 million USA copies in its first week. She's barely uttered a word in public for 18 months , but Taylor Swift is still causing a ruckus on the charts.
It's never too early for a heavyweight tilt in college basketball.
On the season, Duke basketball averages 98.0 points, 45.0 rebounds and 23.5 assists per game.
The Spartans also have key newcomers, so the fresh faces won't all be wearing Duke uniforms.
Bridges' teammates are no slouches, either, of course, as the game is billed as a showdown between potential Final Four teams.
Five players are averaging at least 10.0 points per game for Duke, they are: Bagley III (24.5), Allen (20.0), Gary Trent Jr.
Now, he's a senior, having played in numerous huge games.
Trader's Buzz: Bristol-Myers Squibb Company (BMY)
Whereas, in last 21 trading days (one month) was surged -6.59% and isolated positively in last 63 trading days (quarter) of 5.39%. It is negative, as 53 investors sold PM shares while 558 reduced holdings. 103 funds opened positions while 405 raised stakes.
Duke and Michigan State have the best chance at separating themselves from the field with a win.
Duke leads the series 11-2, winning the past six meetings.
Krzyzewski declined to speak with the media about his latest achievement so he could keep the focus on the game, but that didn't stop his players from expressing their admiration for their coach. Tuesday night will just the first step in said growth.
The game could be heard over the 38-affiliate, Spartan Sports Network, which includes WMMQ-FM (94.9)/WJIM-AM (1240) in Lansing and WJR-AM (760) in Detroit. It's been 12 years - since that 2005 NCAA Tournament win - since Michigan State has taken the Blue Devils down, but this may very well be the most talented Sparta team Izzo has assembled in his tenure.
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Dallas prosecutor fired after audio surfaces of her berating, fighting Uber driver
Once police arrived Platt said he declined to press charges. "You're kind of right.' So I took out my phone and I recorded it". But the cop and Warner , who was 'let off the hook , ' left in a police auto , he told the Dallas Morning News .

domain: sports


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Police files at Public Record Office Victoria contain a letter from Ned Kelly to Sergeant James Babington of the Mansfield police, seeking help. The letter and Babington's response tell us a lot about how the police force worked at the time.
Further InformationWe are currently working on the transcript for this object.
Reading a letter from a young Ned Kelly seeking help.
Filesize: 10.0 MB
For details on reproducing this video or the documents therein, contact Public Record Office Victoria (email@example.com).
State of Victoria

domain: law


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For the most part in 2017 and 2018, only academics and easy-money cranks scolded the Federal Reserve for raising rates. After all, the stock market was bubbling up and the economy was strong.
The economy is still strong, but the stock market has ended its record 10-year bull-market run with a bang. The 20-percent drop in the S&P 500 during one of the worst quarters in market history classifies as a bear market, although prices rebounded at the end of 2018 and in early 2019.
Now everybody from traders to retirees as well as President Donald Trump is scolding Fed Chairman Jerome Powell for his relentless path to higher interest rates and a reduction in the Fed’s balance sheet.
To make a long story short, yes, the Fed is chiefly responsible for this and other stock-market routs, which often precede recessions. There are other contributing factors, such as worries about the Chinese economy and trade, as well as the government shutdown, which will reduce the $1 trillion yearly spending spree of the federal government. But the Fed is at the center of the storm.
And the problem didn’t begin with the Fed’s actions over the past two years. The roots of the issues we now face have their immediate origins in the last financial crisis, but ultimately can be traced back to the founding of the Federal Reserve itself.
The Current Crash
The problem on the surface right now is that the Fed is taking away easy money from market participants and economic agents through its raising of the federal funds rate as well as the $50 billion per month reduction of its balance sheet.
The Fed balance sheet, as well as the federal funds rate, is the foundation of the entire global financial system. For every dollar by which the Fed expands its balance sheet, banks and shadow banks around the world can create many dollars’ worth of debt on top of it.
Terms like balance-sheet expansion and contraction, or quantitative easing (QE) and quantitative tightening (QT), are fancy words for printing money or removing money from circulation.
Since its creation in 1913, the Fed has had the power to print money and fuel booms, and contract money and create busts. So it has to take responsibility for the vicious business cycles since its creation, such as the Great Depression or the 2008 financial crisis.
You can trace this game back to the Fed’s origins, but here, let’s confine it to recent history.
In 1998, the giant hedge fund Long Term Capital Management collapsed and almost took the global financial system with it. The Fed pumped money into the system and we had the dot.com boom, which ended in a bust in 2000 after the Fed had tightened credit conditions.
It then pumped even more into the system to create the subprime boom, which ended in a bigger bust in 2008, again after the Fed had been raising rates for some time.
To “save the system” this time, the Fed boosted its balance sheet to more than $4 trillion and lowered interest rates to zero, in an unprecedented exercise in money printing. This has led to a bubble in corporate debt, student loans, auto loans, and real estate—again.
Popping the Bubble
But booms fueled by money printing usually fuel economic mirages and lead to investments that wouldn’t have been made otherwise, like subprime or dot.com. And even the boom from the past two years has seen a shallow economic recovery, with many people feeling left out.
Now, with interest rates up 2.5 percent, the balance sheet shrinking by $50 billion per month, and the stock market draw-down of 20 percent, we are looking to go into bust mode again.
The stock market reaction this time is particularly pronounced because the market has relied on the Fed to either ease monetary policy or delay tightening whenever there was a correction of 10 percent or so.
The fact that the market reacted so violently to a paltry 2.5 percent increase in rates tells us how dependent it is on easy money. The current Fed Funds rate is still lower than at most other times in recorded history.
And Chairman Powell has made it very clear that he isn’t “market dependent” but would rather follow his usually wrong and inaccurate models, as well as the philosophical concept of the neutral interest rate. He did backpaddle a little bit in early January, but the Fed has a history of talking up markets when talk is cheap.
Because even if the Fed doesn’t raise rates at the next meeting at the end of January, the balance sheet reduction will surely continue.
Either way, the economy can only be put back on solid footing if the bad investments of the boom are liquidated, which always causes asset-price collapses and economic recessions.
If the market is left to its own devices, these contractions are quick and painful, as in 1921, and then provide a solid basis for expansion.
So if Powell’s intention is to pop the bubble and go through the readjustment pain to put the economy on a long-term real growth trajectory, he is doing the right thing, even though he won’t be able to centrally plan the exact right rate for market clearing. But it would be a good start, and would require no bailouts this time around, unlike 2008 when the Fed and the Federal Government bailed out the whole banking system.
Contrary to popular opinion, there are ways and methods to orderly liquidate banks, as investment manager Barry Ritholtz points out:
“Let’s use Bank of America as an example. Bank of America gets nationalized, which really means Uncle Sam provides debtor in possession financing. This is really what happens normally with small companies. Someone who takes them out of bankruptcy give some operating money to keep functioning.
The equity gets down to zero—senior management out the door. There is certainly a layer beneath, which can get promoted without a problem. Bondholders, effectively they are highest in the line of who owns what’s left as the lenders. So they take what comes out of that minus Uncle Sam’s share of providing debtor in possession financing.
And you slowly feed all the pieces to the public. So you clean up the balance sheet and take all that debt. By the way there is no such thing as toxic assets. Well at 100 cents on the dollar they are toxic. But at 15 or 20 cents on the dollar there is plenty of upside there. So you take those assets and auction them off and you take what you get—maybe 15, 20, 25 percent. You take Merrill Lynch, which now has no bad debt on its books and you spin it off as a stand-alone.”
The Fed claims it wants to promote economic stability and improve on the workings of the markets. But history in the 20th century shows that central banking has made business cycles worse than they were under a gold-based system and free banking, although credit crises existed before the Fed and are to be blamed on fractional reserve banking.
On top of that, the dollar has lost more than 90 percent of its value since the Fed’s inception. Stability looks different.
Whether it is incompetence or malevolence, as some historians have suggested, it doesn’t matter, because the Fed can’t replace a free market for capital.
In essence, setting interest rates and printing legal tender and reserves or contracting them at a whim is central planning. And this gets worse because private players are forced to accept Fed money as legal tender and we are forced to use Fed-powered bank money in the payment of taxes.
In fact, central banks look more like a Soviet politburo rather than a competitive market system, although they are privately owned. The few players in control of the system are using the state’s power to reap private profits and pile losses onto the taxpayer.
In contrast, the competitive market system is also the best system for money and banking, not just for other goods.
As economist Murray Rothbard points out, nobody thinks about installing a Board of Governors to supervise shoe production and their prices, so why do we need one to supervise money production and set its price?
In fact, President Franklin D. Roosevelt did think central planning would also be better for shoes and chicken, so he set up private cartels similar to the Fed for almost every industry under the National Industrial Recovery Act.
Unfortunately for him, it was ruled unconstitutional. Not surprisingly, constitutional lawyers like Edwin Vieira and many others believe the Fed isn’t compliant with the U.S. Constitution, of which Article 1, Section 10, states:
“No State shall … coin Money; emit Bills of Credit; make any Thing but gold and silver Coin a Tender in Payment of Debts.”
Now, we have paper and electronic notes issued by the privately owned but not privately accountable Federal Reserve System, with the number of such notes expanded and contracted at will.
The Founding Fathers were rather fond of gold and silver, and were against central banking and the ever-expanding government debt that central banks finance.
“And I sincerely believe with you, that banking establishments are more dangerous than standing armies; [and] that the principle of spending money to be paid by posterity, under the name of funding, is but swindling futurity on a large scale,” Thomas Jefferson wrote in a letter to John Taylor in 1816.
Under the supervision of central banks with the power to print money and a government to bail them out, banks are indeed dangerous and will continue to cause boom-and-bust cycles. However, a return to sound money and competitive banking could put an end to this vicious loop.
Gold has traditionally served as sound money, and it could be used again by the marketplace and even banks to create a free market in capital, similar to the end of the 20th century.
“Look at the era of the classical gold standard, from 1871—the end of the Franco–Prussian War—until the beginning of World War I,” monetary philosopher Saifedean Ammous said.
“There’s a reason why this is known as the Golden Era, the Gilded Age, and La Belle Epoque. It was a time of unrivaled human flourishing all over the world. Economic growth was everywhere. Technology was being spread all over the world. Peace and prosperity were increasing everywhere around the world. Technological innovations were advancing.
“I think this is no coincidence. What the gold standard allowed people to do is to have a store of value that would maintain its value in the future. And that gave people a low time preference, that gave people the incentive to think of the long term, and that made people want to invest in things that would pay off over the long term.”
Ammous, author of “The Bitcoin Standard” also says that Bitcoin could serve as the digital gold of the future and replace the current system even without official government adoption.
But whether gold or Bitcoin, sound money would serve as a stable basis for the banking system, banks would have to be set free from the control of the Federal Reserve, be accountable for their actions, and be allowed to fail if they make bad investments.
This would remove moral hazard and create a more accurate clearing price for capital, which wouldn’t prevent, but would greatly reduce malinvestments and business cycles.
Chance for the Future
Given its dismal track record and probable unconstitutionality, the Federal Reserve System should be dissolved and sound money returned to the United States and the globe.
The fact that Powell is maneuvering us into the bust cycle could provide the opportunity to execute this momentous plan.
The promoters of the Fed used the stock market and economic crisis of 1907 to push its creation through Congress in 1913.
If this bust cycle is going to be worse than 2008—and by many financial metrics, it well could be—the political elite around Trump could use the next crisis to do the reverse of 2008 and 1913.
This article is part of a special Epoch Times series on the Federal Reserve. Click here to see all articles.
Views expressed in this article are the opinions of the author and do not necessarily reflect the views of The Epoch Times.


In February 2019, China's Jihai Year of the pig is coming, and Soomal's annual insights and recommendations were updated today. There are recommendations of 2018 after the audio, phone and camera insights. In 2019, Soomal also celebrated its tenth anniversary after reopening, thanking the netizens for their long support.
Our vision in 2015 and 2016 and our expectation in 2017 for the smart speaker market, unexpectedly broke out somewhat in the second half of the year 2018. The outbreak has been fueled by capital. Jingdong, Ali, Baidu, Tencent and other giants have been brewing for two or three years, but the smart speaker market is tepid, which is a huge contrast with Amazon Echo and Google Home on the other side of the ocean. Ali and Baidu's huge subsidy market strategy will bring the price of smart speakers to 60-80 yuan (about $ 10 ¨C 12). According to their respective official reports, Ali Tmall Genie, Baidu smart speaker products, in the 2nd of the year 2018, the sales volume must be between 1 million and 3 million or more, the capital subsidies amount has also reached several hundred million yuan. The price of Xiaomi XiaoAI's is not too high, and the old Jingdong Dingdong mini2 is also forced to release at a price of 79 yuan (about $12). The market suddenly has a bloody storm.
According to the data by Canalys, after the launch of the strong subsidy program in the third quarter of 2018, smart speakers increased sales by 5.8 million units this quarter, and finally broke the gap with the US market. Ali, Baidu, Xiaomi, and Dingdong are expected to occupy the first four. Ali and Baidu, which have more subsidies, have grown rapidly. The market share of Baidu's small series speakers has surged to 24%, ranking first in terms of market share. According to Strategy AnalyTics data, Baidu also accounted for 8% of the global market share, 22.7 million, in the third quarter.
Ali Tmall Genie X1 in the double 11, 2017, first triggered a price war, relying on the huge promotion frequency of Tmall and Taobao, the actual transaction price was only 99 yuan. This subsidy effect has continued to affect 2018. In the first half of 2018, the sales of Tmall Genie X1 exceeded 3 million units. I am afraid this also gave birth to the subsidy strategy of Baidu and Dingdong mini2 in 2018.Xiaomi Xiao AI have sold more than one million in the last year, and the sales in the first half of 2018 broke through 1 million. At present, according to the hardware revenue analysis of the Iflytek, Jingdong's smart speaker sales are not good, and the half-year sales are expected to be less than 300,000 units, but still the top 4. However, in 2016, the market share of Dingdong is probably above 60%.
Market analysis company GFK predicts that the sales volume of smart speaker retail market in China will reach 9 million units in 2018, while AVC (Aowei Cloud) expects sales volume to reach 16.25 million units. From the main reports, the market scale of 10 million units will be reached. Several major brands have basically completed a large increase in sales of over 2 million units in the whole year. In 2016-2017, our market once expected to break through 1 million units of sales as soon as Amazon Echo, and quickly passed the incubation period, which is in 2018. Some accidents were quickly completed in the year.
Looking back at the changes in smart speakers in the global market, and especially the US market. According to the forecast a year ago, the penetration rate of smart speaker families in the United States will increase significantly in 2018, which is 16% in 2017 and 75% in 2020. This speed is actually faster than expected. According to Canalys, the household penetration rate of unfinished smart speakers in the fourth quarter of 2018 is about 45%, and the target of nearly 50% can be achieved throughout the year. Products such as Google Home and Echo also compete in the market through subsidies and low-cost positioning. Echo shares are around 70%, Google Home shares are 23.8%, and Apple HomePod is said to have a market share of around 4%. If there is, it is already very good for high priced products. But for smart speakers, ecological penetration may be more important.


When it comes to maintaining a comfy and healthy and balanced indoor atmosphere, couple of points are as crucial as an effectively operating a/c system. A HVAC (Heating, Ventilation, and also Cooling) system is accountable for managing temperature level, moisture, and air high quality in residences, offices, and industrial spaces. While looking after small a/c concerns on your own may appear alluring, it is vital to recognize the value of hiring an expert cooling and heating specialist for all your system requires.
1. Knowledge as well as Expertise:
Professional a/c service providers have the essential expertise and knowledge to deal with numerous HVAC systems efficiently. They have undertaken customized training and have years of experience in the field. This suggests that they are skilled in diagnosing as well as troubleshooting cooling and heating problems, making certain exact repair work and setups. Their proficiency enables them to provide high-grade services and also settle issues in a prompt manner.
2. Proper Installation:
Correct setup is key to maximizing the performance as well as longevity of your a/c system. An expert a/c service provider understands the ins and also outs of various a/c systems as well as can guarantee that your unit is installed properly. They will certainly follow manufacturer standards and also sector criteria to ensure that your heating and cooling system operates at its optimal degree, reducing the danger of future troubles and also ensuring energy effectiveness.
3. Boosted Power Effectiveness:
A specialist heating and cooling service provider can aid you optimize the energy performance of your a/c system, which can bring about considerable price savings over time. They can suggest you on the best techniques, advise energy-efficient devices, and do routine maintenance to make certain that your system is performing ideally. By maintaining your system in leading condition, they can help reduce energy usage and lower your utility bills.
4. Safety and security as well as Conformity:
Taking care of heating and cooling systems involves certain dangers, specifically if you lack the needed expertise and experience. Specialist cooling and heating contractors adhere to stringent security protocols to make sure that setups and repair work are done securely and also successfully. They recognize with building regulations and policies, ensuring that your system meets all needed requirements. This not only maintains you and also your building secure yet also avoids possible penalties or penalties that can result from non-compliance.
In conclusion, employing a specialist heating and cooling contractor is crucial when it involves ensuring the ideal efficiency and durability of your cooling and heating system. Their understanding, knowledge, and also dedication to safety as well as compliance make them the very best choice for all your cooling and heating requires. Don’t endanger on the convenience and top quality of your indoor environment– count on the specialists to finish the job right!


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The babushka, the alarm clock and the art of fundraising
Nonprofit Marketing Blog
SEPTEMBER 20, 2011
Once upon a time, when I was living in Ukraine, I met the staff of a community foundation named Dobrata that was trying to encourage businesspeople to give money to charitable causes. The main problems: lack of a clear audience and an appeal to that audience’s values. It was depressing—everyone in Ukraine knows the collapse of the Soviet Union hit pensioners hardest—but not personally motivating.

domain: sociology


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Tackling the China challenge requires a strategic response. Trumps scattershot policy will be counterproductive, writes Michael F Fuchs
In recent months, Donald Trump has launched Americas new buckshot approach to China hit China everywhere and see what works. On Wednesday, Vice-President Mike Pence gave a speech to articulate this new get tough policy. The strategy includes starting a trade war and shining a spotlight on Chinas propaganda in the United States, with presumably more to come.
Faced with real threats from China that require a strategic response, this scattershot policy will be counterproductive. The trade war is the perfect example of the drawbacks: using indiscriminate tariffs in an unlikely attempt to change Chinas economy will only hurt America and its allies without solving the real problems American businesses face in China.
Its become fashionable in Washington to be tough on China. As Chinas assertiveness in maritime disputes with neighbors has increased, and as its economic influence around the world has grown, so too have the calls for a tougher policy on China.
Without a doubt, we need to push back on China in certain realms. But as America contends with the growing debate over China policy, the challenge is to be specific and realistic without succumbing to an all-encompassing, self-defeating anti-China approach akin to a new cold war.
There are more than enough areas of concern to focus on. Chinas assertiveness at sea evidenced by a recent dangerous close encounter between US and Chinese vessels threatens to destabilize Asia. Chinas outright theft of American intellectual property rights threatens American prosperity.
But not every single thing that China does is threatening. Its commitment to curb emissions as part of the Paris climate agreement is positive, and the world will not tackle climate change without China.
There are murkier areas too. Chinas Belt and Road initiative to invest hundreds of billions in infrastructure abroad could be both good and bad: good when investing in infrastructure that benefits all; bad when used to foster debt trap diplomacy that China uses to secure strategic real estate for military purposes, as it did in Sri Lanka.
US policy must also be informed by realistic assessments of what we can achieve. For instance, the Chinese Communist party (CCP) is unlikely to respond to tariffs by changing the entire Chinese economic model; a more targeted strategy to prevent IPR theft from American firms is more likely to succeed.
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domain: politics


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The Grolier Club Library is pleased to announce the receipt of a major gift, the Collection on the Detection of Forged Handwriting, which is the most important and comprehensive collection on the subject known to exist anywhere. The Gift is from club members Kenneth W. Rendell and Shirley McNerney.
Rendell, a leading dealer in historical letters and documents, has exposed numerous famous forgeries such as the Hitler Diaries fraud, Mussolini’s diaries, the Mormon forgeries and murders [with forger Mark Hofmann], and Jack the Ripper’s forged diary. This collection was formed over a 60-year period and consists of thousands of forgeries, facsimiles of handwriting, reference books, and archival files concerning major cases in which Rendell has been involved.
The collection is wide-ranging, encompassing historical letters and manuscripts from the early 17th century to the modern day. Classic forgeries of Shakespeare, Robert Burns, Schiller, Washington, Lincoln, Franklin, Berlioz, Wagner, Poe and numerous others are included. Rendell made every effort over his long and distinguished career to acquire original examples of past forgers from many sources, including the files of dealers such as Charles Hamilton, Mary Benjamin and Goodspeeds.
The gathering together of so many “original” forgeries – often destroyed and notoriously difficult to collect – alongside genuine examples of handwriting and a specialized reference library, gives the collection unparalleled value for study. Thanks to the generosity of Rendell and McNerney, these materials will be made widely available to researchers, scholars, librarians, Grolier Club members, dealers, and the public for the first time.
The collection consists of:
10,000 facsimiles of the handwriting of prominent persons from the 17th to the 20th centuries
160 forgeries created to deceive, usually for profit
400 “authorized forgeries” intended to deceive people into thinking they are genuinely signed, usually by an authority figure (e.g., members of royalty, American presidents)
75 “mistaken identities,” in which two different people with the same name living in the same place and time are confused with each other (e.g., two people named John Adams”)
29 facsimiles frequently mistaken as genuine (Longfellow, Twain, etc.)
140 reference books on forgery detection
8 linear feet of archival files relating to major forgery cases in which Mr. Rendell was involved, including the Hitler diaries, the Mussolini diary, the Jack the Ripper diary, the Mormon forgeries, the John F. Kennedy/Cusak fraud, and the Elvis Presley musical manuscript forgeries
Research files and photographs compiled by Rendell for his book, Forging History: The Detection of Forged Historical Manuscripts (University of Oklahoma Press, 1994)
The gift of the Collection on the Detection of Forged Handwriting also includes a monetary gift to enhance accessibility to the collection through professional cataloguing. Through their donation to the Grolier Club, Rendell and McNerney have ensured the preservation of this material is a publicly accessible institution, where it can be studied by anyone with an interest in the history, analysis, and detection of forged documents. We are grateful to them for their foresight and extraordinary generosity.
For more information, contact
Meghan R. Constantinou, M.A., M.L.I.S. Librarian
The Grolier Club
47 East 60th Street
New York, N.Y. 10022
Phone: 212-838-6690 ext. 5
e-mail: firstname.lastname@example.org website: www.grolierclub.org


How Casper Smart Plays Dad to Jennifer Lopez's Twins
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- Photo: CWNY/Fame Flynet15 of 29
- Photo: Wagner Az/Pacific Coast News16 of 29
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Jennifer Lopez isn't the only one getting pampered by Casper Smart.
The backup dancer-turned-choreographer makes it a point to spoil her 4-year-old twins (with ex Marc Anthony), and stopped by a recent Xbox 360 event in L.A. to score some games for Max and Emme.
"He was going on about how he loves playing with them," says a witness.
Smart, 25, is equally enamored of his girl, 43.
"He's madly in love with her," the insider says of Smart, who will join Lopez on the European leg of her tour in October.
Adds the source, "It's not just that she's his lover, she's also his best friend."
Smart and Lopez first stepped out together in Fall 2011, just a few months after her painful July split from Anthony, whom she wed in 2004.
During her Sept. 14 appearance on Katie Couric's talk show, Lopez opened up about the much-discussed 18-year age difference between her and her new man.
"Until somebody brings it up, I don't think we really think about it," the singer revealed. "We're just two people who have similar interests and love a lot of the same things and who get along."
This article originally appeared on Usmagazine.com: How Casper Smart Plays Dad to Jennifer Lopez's Twins
MORE ON WONDERWALL:
From Mila Kunis to Mary-Kate Olsen, get the scoop on all the engagements in Hollywood on Replay.Watch Video »
Rihanna, Katy Perry, and Heidi Klum all get an F on this week's Fashion Offenders.Watch Video »
From Katy Perry and John Mayer to Paula Patton and Robin Thicke, get the scoop on all the breakups in Hollywood.Watch Video »
The Rock flexes massive muscle while getting sentimental on Celebs Gone Social hosted by Wonderwall editor Chris Gardner.Watch Video »
Get the scoop on Julianne's hunky Canadian hockey beau on Replay hosted by Wonderwall's Kirby Kristen.Watch Video »
Get the scoop on all the rumors surrounding Eva Mendes and Ryan Gosling on Replay hosted by Wonderwall's Kirby Kristen.Watch Video »
From Crowd Ignite


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100 E Walton St, Chicago, IL 60611 312-664-1700
Description: GOLD COAST. This elegant restaurant specializes in Northern Indian cuisine and is known for its tandoori cooking. Clay ovens powered by mesquite wood cook not only breads but fish, chicken, and lamb to perfection. The unobtrusive, attentive staff and tasteful interior create an upscale dining experience. A lunch buffet adds value, and curries are also an earthy, delicious treat.
Mon-Thu 11:30am-2:30pm, 5pm-9:30pm; Fri 11:30am-2:30pm, 5pm-10pm; Sat Noon-3pm, 5pm-10pm; Sun Noon-3pm, 5pm-9:30pm
Visa,Master Card,Discover,American Express,Diner's Club
Visit Gaylord India Restaurant Online

domain: food


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While an October exhibition of Macedonian medieval manuscripts in Brussels incited protests from the government in Sofia over historical issues, there is another collection of texts in the country about which relatively little is known- that is, Macedonia’s Islamic manuscript collection, a legacy from Ottoman times. In this intriguing new interview, Balkanalysis.com Director Chris Deliso gets the insights of Prof. Dr. Mesut Idriz, an expert on the subject who has done considerable research on the history, identity and preservation possibilities of Islamic manuscripts from Macedonia.
...over 120 Chinese students took part in a special educational exchange with local government and community leaders and European students in the famous port city of Antwerp, Belgium to commemorate EU Youth Week and the "EU-China Year of Youth".
What was Joseph Kabila thinking? According to Congolese and Belgian press, President Kabila gave Queen Paola of Belgium a diamond necklace, earrings, and bracelet on the occasion of Congo's 50th anniversary celebrations. A bit of a PR catastrophe.
Olivier Chastel, the Belgian secretary of state for EU affairs...raised the possibility of the opening of a new chapter in negotiations with Turkey in the coming months after Spain, which currently holds the EU presidency, backed Ankara's bid despite resistance from France and Germany.
APDS Blogger: Paul Rockower
With the recent earthquakes that devastated Haiti and Chile, the concept of aid diplomacy has arisen in the global consciousness. Aid diplomacy is predicated on the notion that in times of crisis, nations can do well in public diplomacy terms by doing good works for those in need.
Belgian Prime Minister Yves Leterme says the creation of a European Union foreign minister — the job currently held by the U.K.'s Catherine Ashton — has freed him up to conduct what he calls "economic diplomacy."
THE Smurfs, the Little Mermaid, Bollywood stars, tenor Andrea Bocelli and the acrobats of Cirque du Soleil are part of a colourful diplomatic offensive to win Chinese hearts at this year's World Expo.


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Nollywood which is one of the biggest movie industry in Africa, is blessed with a large number of entertainers, in all categories. It will be recalled that one of the Nollywood actress who came into acting right from childhood and is still making waves and a force to reckon with is, Regina Daniels. The billionaire’s wife started her acting career at the age of 6, as she got all the support and motivation from her mother, Rita Daniels, who is also an actress and a producer.
Following the footsteps of Regina, there is a new kid on the block, as she is ready to take the crown off Regina who has slowed her acting pace due to marriage. So who’s the new kid? Adaeze Oby Onuigbo!
Adaeze Onuigbo is a fast rising Nollywood teenage actress, model, dancer and a television personality. Adaeze was born, 2 September 2005, in Asaba, Delta State Nigeria. She is popularly known for playing the role of a kid in several Nollywood movies.
Adaeze who has acted in over 30 movies can be easily called ‘the heir to Regina’s throne’, as her energy, commitment and role commands, speaks highly of her. Some of her notable movie features includes; The Stolen Crown, The Strange Shrine, Return Sharon, Festival of Reality, Lion Hearts, etc.
Photos of Adaeze:
What do you think, is Adaeze ready to take over?


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King Charles II
King Charles II
by Frederick Hendrik van Hove, after Sir Godfrey Kneller, Bt, published by Richard Chiswell
line engraving, mid to late 17th century
4 7/8 in. x 3 1/4 in. (124 mm x 84 mm) plate size
Given by the daughter of compiler William Fleming MD, Mary Elizabeth Stopford (née Fleming), 1931
Sitterback to top
- King Charles II (1630-1685), Reigned 1660-85. Sitter associated with 295 portraits.
Artistsback to top
- Richard Chiswell (1640-1711), Bookseller. Artist associated with 15 portraits.
- Sir Godfrey Kneller, Bt (1646-1723), Portrait painter. Artist associated with 1686 portraits, Sitter associated with 30 portraits.
- Frederick Hendrik van Hove (circa 1628-1698), Engraver. Artist associated with 79 portraits.
Events of 1630back to top
Current affairsCharles I's first surviving child, Charles, is born in St. James's Palace. He is baptised by the Anglican Bishop of London, William Laud, and brought up in the care of the Protestant Mary Curzon, Countess of Dorset.
Art and scienceThe Cottonian Library, containing the greatest resource of Old English and Middle English literature, founded by antiquary and anti-royalist, Sir Robert Bruce Cotton, is confiscated by the authorities.
InternationalPhilip IV of Spain and Charles I sign the Treaty of Madrid, ending hostilities between the two countries. Spanish diplomat, Cesare Alessandro Scaglia, assists with the conclusion of the peace deal.
German, Protestant land is regained from Catholic allies on account of Swedish intervention in the Thirty Years' War.
- Painted Ladies: Women at the Court of Charles II
- Restoration Lives: Samuel Pepys and His Circle
- Charles II and the Oak Tree
- Charles II
- The First Actresses: Nell Gwyn to Sarah Siddons
- Kings and Queens: A Family tree
- Alexander Browne and Richard Tompson
- NPG D2930 in 360°
- Handlist of names in the Reference Collection
- Party Trail
Tell us more
Framed & unframed prints

domain: history


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Superstar Mahesh Babu’s most awaited film ‘Aagadu’ is fast completing its shoot. Meanwhile, the makers have planned a grand audio release on the 30th of this month in Shilpakala Vedika, Hyderabad. Mahesh plays a powerful encounter specialist role in this film which is directed by Sreenu Vaitla.
SS Taman is scoring music for this action entertainer. ‘Aagadu’ features Shruthi Hasan in a special song. 14 Reels Entertainment, who earlier produced Mahesh’s films like ‘Dookudu’ and ‘1 Nenokadine’ is producing this big budget film.
- I Learnt A Lot From Kalyanram : Kajal
- MLA is my most satisfying movie after Pataas: Kalyanram
- Young hero hikes his remuneration
- Star hero donates Rs.10 lakhs to retired cops trust
- Rana, Arya to steal the show in Rajaratham


New fuel claims to restore lost engine glory
As automotive technologies evolve towards smaller, albeit more powerful internal combustion engines, the fuel that powers them needs to level up.
Shell fuel specialist Mae Ascan revealed to media during the June 8 Shell V Power fuels launch that this trend has prompted Shell to introduce its newest fuels with Dynaflex technology.
This time, she says, Shell offers fuels to not only power modern engines, but to provide powerful cleaning and friction-reducing molecules.
She explained, “Vehicle manufacturers are squeezing in more power into smaller engines. This exposes your fuel to harsher conditions, and makes it work at a higher temperature, higher pressures, and higher engine load. The engine becomes more prone to deposits, which means your engine becomes dirty, which can have an adverse impact on the overall performance and efficiency of the engine.”
This is where Shell’s Dynaflex technology comes in.
Ascan revealed that it took the Shell fuel team of over 170 scientists and specialists five years, more than 250 cars, in over 3 million km of testing in different countries across Asia, America and Europe.
Ascan claimed that the V-Power Racing and V-Power Gasoline can remove up to 80 percent of deposits, with the twin effect of improving system condition and restoring lost performance.
She added: “V Power diesel is designed to restore up to 100 percent of your engine performance by removing deposits from fuel injectors. This is the first time that we are claiming up to 100 percent engine performance.”
What Ascan isn’t certain about, however, is when that 100 percent could be achieved in your car. “It depends on a lot of factors, as well, such as how much deposits you have in your engine.”
Her guarantee, however, remains. “We substantiate our claims. It’s designed to work in old and new cars.”
She described that Shell maintains an innovation partnership with Scuderia Ferrari, with Shell spending 21,000 hours every year with the organization.
“We use Scuderia Ferrari as our testbed. When it comes down to performance, what better way to do that than in a Formula 1 track using a Formula 1 car. The learning we pick up from there we apply to our V Power fuels.”
Anthony Lawrence Yam, Pilipinas Shell VP for retail, said: “We are constantly faced with the challenge to keep up with the rapid evolution of vehicle technology and the changing needs of our customers. This is why we have spent over half a decade of research and development to produce our best-ever fuel.”


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Byron-Bethany Irrigation District near Byron, Contra Costa, Co., Calif.
San Francisco, Fred H. Tibbetts, 1920.
Full Collection Name
Historic maps of the Bay Area
G4363.C6J4 1920 .B8
[ca. 1:36,500]. 1 in. = 3000 ft.
Other Physical Details
70 x 49 cm
Earth Sciences & Map Library
Shows irrigation facilities, existing and proposed canals, telephone lines, fences, roads, etc.
Includes "Location sketch."

domain: library


Vision, Mission and Values
To be a leader in connecting citizens, communities and businesses with government services and a valued partner in the delivery
of innovative services to the public sector.
Champion the transformation of government service delivery to respond to the everyday needs of citizens, businesses and the
Values and Culture
Citizens' Services plays a leadership role in transforming service delivery to British Columbians. Fulfilling this role depends
on a committed and skilled work force operating in a customer-focused, innovative and results-oriented culture. Our values
guide us in attaining our goals and are reflected in our objectives and performance measures.
||Services anticipate and respond to the needs of our customers and clients.
||Performance is measured to ensure cost-effective business outcomes and value-added results.
||Leading-edge, creative and integrated approaches are implemented.
||Clients and stakeholders are actively engaged in value-added solutions.
|Work As A Team
||Staff work together to achieve results and maximize resources.
Individuals and teams that achieve results and demonstrate creativity and calculated risk-taking are recognized.
||Individuals are treated with fairness, dignity and respect.
||Actions and communications are open and transparent.
Planning Context and Key Strategic Issues
The following challenges and opportunities were identified as potentially affecting the Citizens' Services area of the ministry.
- Increase accessibility for citizens, businesses and the public sector to government-wide information and services. Utilize
a variety of channels (face-to-face, telephone and Internet), increase broadband access and support the ease of use of these
tools and lead Canada in the provision of citizen's services in multiple languages including First Nations' languages.
- Integrate government services in a way that allows citizens to access whatever they need from government, from wherever
they live and by whatever avenue they choose.
- Continue to be leaders in innovative public sector service delivery by developing integrated end-to-end shared services
and by reducing costs. This will include successfully transitioning BCBC into Public Service Operations. Leverage the benefits
from successful public/private partnerships to enhance service delivery and build on the modern, efficient, and scaleable
provincial information and technology infrastructure.
- Support government's efforts to develop a powerful image that brands British Columbia as the best place to live and work.
- Realize the full potential of the Knowledge Network including reaching out to British Columbians with information about
services, tourism, business opportunities and quality of life.
- Integrated service delivery depends on public confidence in government's ability to guarantee the security of private information.
A sophisticated ability to identify and authenticate clients who wish to access services will be built by ensuring service
delivery channels and infrastructure are secure and privacy is maintained.
- Integrated service delivery also depends on having infrastructure in place in all of B.C.'s communities and a high level of
access by citizens.
- Being a leader in innovative service delivery carries the inherent risks of being the first to do things in a new way. Maintaining
leadership also requires investment and the ability to attract and retain a talented and appropriately skilled workforce in
an increasingly competitive market place.


With restrictions being eased around the world, prepare yourself to get back to normal with our stylish three-layer reusable face masks, which are machine washable at up to 60°C.
The face masks are not an item of PPE or a medical device, but they are an important accessory and one that may be compulsory for certain activities in this difficult time, for example when using public transport or services such as hairdressers.. These are great value for money.
Adult would be suitable for anybody around the age of 15 + (size:16.8 x 16 cm)
Child would be suitable for age 5+ (size:13.8 x 13.7 cm)
Triple-Layer Masks consist of three layers: the outer layer is stretchy, crease- and fire-resistant 100% polyester; the second layer is 100% polypropylene with nanofibre and provides 95% filtration efficiency for up to 25 washes; and the third layer that touches the skin is lightweight and breathable 100% polyester. This makes the reusable face masks comfortable even when worn for long periods of time.