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Institut Pasteur Press Office firstname.lastname@example.org
The cochlear sensory epithelium (organ of Corti), and the vestibular sensory epithelia, ampullar cristas (inset) of the inner ear ijntected with the AAV8 virus producing GFP and the SANS protein. The cochlear and vestibular sensory cells were immunostained for GFP and myosin VI and analyzed with a confocal microscope. The green and orange cells produce the protein of the therapeutic gene. © Institut PasteurScientists from the Institut Pasteur, Inserm, the CNRS, Collège de France, University Pierre et Marie Curie, and University Clermont Auvergne*, have recently restored hearing and balance in a mouse model of Usher syndrome type 1G (USH1G) characterized by profound congenital deafness and vestibular disorders caused by severe dysmorphogenesis of the mechanoelectrical transduction apparatus of the inner ear’s sensory cells. By locally injecting the USH1G gene, critical for the formation and maintenance of the hair bundle, the mechanosensory antenna of these cells, the scientists successfully restored the function and the structure of this apparatus, resulting in the first recovery of hearing and balance by gene therapy for this mouse model. These findings, published in the journal PNAS, open up new possibilities for the development of gene therapy treatments for hereditary forms of deafness. Hearing loss, sometimes associated with other disorders such as balance defects, is the most common sensory deficit, affecting more than 280 million people worldwide, according to WHO. In France, one child in 700 is born with severe or profound hearing loss, and one in every 1,000 will lose their sense of hearing before adulthood. Over the past 20 years, scientists have made remarkable progress in deciphering the genetic origins of congenital hereditary hearing loss, which is usually caused by inner ear dysfunction. The inner ear comprises the hearing organ or cochlea, together with the five balance organs (the saccule, utricle and three semicircular canals), which contain the sensory cells, or hair cells, that detect mechanical vibrations and convert them into electrical signals. To date, mutations in more than 100 genes have been associated with inner ear defects, and it is estimated that mutations in more than 100 genes can cause genetic forms of deafness. The various hereditary forms of hearing loss include Usher syndrome type 1 (USH1), a particularly severe clinical form of deaf-blindness, and specifically the USH1G genetic form. USH1G patients are profoundly deaf and have no balance function at birth, and they subsequently suffer from prepubertal-onset sight loss leading to blindness. USH1G syndrome is due to mutations in the gene encoding the scaffold protein sans, which is essential for the cohesion of the hair bundle of the inner ear hair cells. Patients with hearing loss and balance dysfunction are currently fitted with auditory prostheses and may be given balance rehabilitation therapy, but the outcomes are variable. One possible alternative for treating such hereditary inner ear defects is gene therapy. This approach entails transferring a healthy (non-mutant) copy of the defective gene to restore the expression of the missing protein. So far, gene therapy attempts have only resulted in partial improvements of hearing in mouse models of specific human deafness forms that did not include severe anomalies in hair cell structure. In this context, scientists from the Institut Pasteur, Inserm, the CNRS, Collège de France, University Pierre et Marie Curie, and University Clermont Auvergne*, have now succeeded in restoring hearing and balance in a mouse model of USH1G syndrome using gene therapy. With a single local injection of the USH1G gene just after birth, the scientists observed a restoration of the structure and mechanosensory function of the inner ear hair bundles – profoundly damaged before birth –, resulting in a long-term partial recovery of hearing, and complete recovery of vestibular function in these mice. These results unexpectedly establish that inner ear defects due to major morphogenetic abnormalities of the hair bundle can be reversed even after birth, with durable efficacy, by gene therapy.
Hair bundles of vestibular sensory cells analyzed using scanning electron microscopy. The image shows a normal hair bundle with its characteristic "staircase" pattern (in yellow), a defective Usher type 1G hair bundle (in pink) and a treated Usher type 1G hair bundle (in green), whose normal/characteristic form was restored with gene therapy. © Institut PasteurThe scientists injected the USH1G gene into the inner ear using the innocuous AAV8 virus, which enabled them to specifically target the hair cells. The expression of the therapeutic gene was detected 48 hours after injection. The team demonstrated that a single injection to restore the production and localization of the missing protein in hair cells successfully improved hearing and balance functions in the young mice. These findings suggest that the therapeutic protein was able to interact normally with its binding partners among the USH1 molecular complex (the proteins cadherin 23, protocadherin 15, myosin VIIA and harmonin), as required for the mechanoelectrical transduction apparatus of the hair bundle to function correctly. As Saaïd Safieddine, CNRS Director of Research at the Institut Pasteur and co-senior author of the study with Prof. Christine Petit, explains, "we have just shown that it is possible to partially correct a specific form of hereditary hearing loss accompanied by balance problems using local gene therapy performed after the embryogenesis of the ear, which is primarily affected by the mutation responsible for the disorder. This suggests that the time window for effectively treating USH1 syndrome using gene therapy may be larger than initially thought." This study represents a significant step towards the development of clinical trials in gene therapy for the curative treatment of hereditary deafness and balance loss in humans.
Sorry, this entry is only available in French. For the sake of viewer convenience, the content is shown below in the alternative language. You may click the link to switch the active language.[1_synthese_titre]Début de la campagne ...
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Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G, PNAS, 5 septembre 2017 Alice Emptoz (a,b,c), Vincent Michela (b,c), Andrea Lellia (b,c), Omar Akil (d), Jacques Boutet de Monvela (b,c), Ghizlene Lahloua (b,c), Anaïs Meyera (b), Typhaine Duponta (b,c), Sylvie Nouaillea (b,c), Elody Ey €, Filipa Franca de Barros (f), Mathieu Beraneck (f), Didier Dulon (g), Jean-Pierre Hardelina (b,c), Lawrence Lustig (h), Paul Avan (i), Christine Petita (b,c,j), and Saaid Safieddine (a,b,c). (a) INSERM, UMR 1120, Paris, France. (b) Génétique et Physiologie de l’Audition, Institut Pasteur, 75015 Paris, France. (c) Complexité du Vivant, Sorbonne Universités, Université Pierre-et-Marie-Curie, Université Paris VI, 75015 Paris, France. (d) Otolaryngology-Head & Neck Surgery, University of California, San Francisco, CA 94117. (e) Unité de Génétique Humaine et Fonctions Cognitives, Institut Pasteur, CNRS UMR 3571, 75015 Paris, France. (f) Centre de Neurophysique, Physiologie, et Pathologie, CNRS UMR 8119, Université Paris-Descartes, 75006 Paris, France. (g) Laboratoire de Neurophysiologie de la Synapse Auditive, Bordeaux Neurocampus, INSERM, UMR 1120, Université de Bordeaux, 33076 Bordeaux, France. (h) Columbia University School of Medicine and New York Presbyterian Hospital, New York, NY 10034. (i) Laboratoire de Biophysique Sensorielle, Faculté de Médecine, Université d’Auvergne, Biophysique Médicale, Centre Jean Perrin, 63000 Clermont-Ferrand, France. (j) Collège de France, 75005 Paris, France DOI : 10.1073/pnas.1708894114

domain: biology


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If you still have no plans, we invite you to read our post about weekend events in Valencia. Our Spanish school, El Rincón del Tándem, has, as always, made a small selection, so take a look! 😊
The time has come for students at our Spanish school to take a break from studying and take part in the weekend events in Valencia.
If you like theatre, dance and art in general, today’s post will help you make plans for the next two days.
Here we go!
From the 12th to the 22nd of May
Theatres and public spaces in Mislata
The VIII edition of the MAC- Mislata Art al Carrer opens today. Another essential event for lovers of the performing arts.
Like other Valencian festivals, the MAC has the merit of taking theatre and performances out of conventional spaces to reach a wider audience.
This year’s festival features around 15 renowned companies from all over Spain.
Until May 22, performances will take place in cultural centres, streets, squares, theatres and amphitheatres.
Here are some of the shows taking place this weekend:
- C-Dansa, Conservatorio profesional de Danza de Valencia. Friday 13 at 7pm in Gregorio Gea Av.
- A-TA-KA!, Cal y Canto. Avant-garde show inspired by the melted dreams of Salvador Dalí. At 7pm in Plaza Mayor.
- Out of Stock, Edu Manazas. Narration through the circus about work, people and their yearnings.
It all sounds too good to miss, doesn’t it?
Click here for the full programme of the festival.
Factoría d’Arts de Patraix
Till the 25th of May
This weekend, Patraix celebrates the 5th edition of Factoría d’Arts.
Factoría D’Arts is an event whose aim is to revitalise the neighbourhood through art and culture, creating spaces for meetings and dialogue.
The event celebrates different types of arts, specifically illustration, music, dance and performing arts.
This Saturday the streets of the Patraix neighbourhood will be filled with voices and colours, thanks to a programme that includes activities for adults and kids.
In the rich calendar of Saturday 14th, we highlight some events, such as:
- Patarix illustration market, from 11am to 2pm and from 5pm to 9pm in Salabert Street.
- The Performance Policromia. Participatory allegory against intolerance. At 12.30pm in Salabert Street.
- El Passeig Muralisme. Street Art route in the Patraix neighbourhood, at 6.30pm.
- VICA Singer’s Circle Recital. Concert of Folk songs from Ireland and other charming places. At 7pm in Sankofa space.
For the full programme, please visit the event’s website.
Feria Andaluza de Valencia
Form the 13th to the 22nd of May
Solar de Marco Sopena, Calle Doctor Marcos Sopena 25 (Marina de Valencia)
The event, organised by the Federación de Entidades Culturales Andaluzas de la Comunidad Valenciana, moves this year to the Marina de Valencia.
In fact, the Solar de la calle Sopena will host this great festival until May 22. As usual, the fair will feature the typical Andalusian “casetas” and a rich programme of events.
Among them, there will be performances of traditional music and dances, a parade of flamenco dresses, and other cultural displays.
And, by the way, it will be an opportunity to taste the delights of Andalusian gastronomy and typical drinks such as rebujito and manzanilla…
Cicle Carme’n’Dansa: Nimbes
From the 12th to the 15th of May
Sala Carme Teatre, C/Gregorio Gea 6 bajo
Ticket: from 8 euros
This May the Teatre Carme celebrates the 5th edition of Carme’n’Dansa. A cycle dedicated to contemporary dance.
This weekend, the theatre will host Nimbes, by the Valencian company Fil d’Arena. Nimbes tells us through dance about the strength of women that comes from mutual support and networks.
The protagonists are not extraordinary women or heroines, but ordinary people who, in their daily lives or due to life circumstances, show courage and bravery.
Nimbes is also about networks, shared space and inherited wisdom that is passed on from one generation to the next.
You can get your ticket here 🙂
We hope you find our selection of weekend events in Valencia useful.
Finally, our Spanish language school El Rincón del Tándem invites you to enjoy the cultural life of Valencia and to continue practising your Spanish outside the classroom.

domain: artistic


Welcome back to Takeover Tuesday, where each week Billboard taps chart-topping artists and taste-makers to compile their very own playlist exclusive to Billboard’s Spotify account. We give the artists free reign to base the list on whatever subject they choose. The only rule? Make it as creative and unique to them as possible.
Nashville-based indie pop band COIN kick off the final leg of their North American tour today (March 6) in Arizona, and have given Billboard an exclusive look at what jams they have been listening to while prepping for tour.
The band is known for their upbeat, guitar-fueled songs, so it’s no surprise their favorites include some of the same. “Over the past few years of being in COIN, each of these songs has so perfectly depicted where I am in my life,” lead singer Chase Lawrence told Billboard. “These are my once, current and always anthems.”
Their picks include “The Reeling,” a synth-Heavy track from Passion Pit, the fun rock track “These Days” from Dr. Dog and “Monsoon,” a dreamy slow jam from Hippo Campus. The group also added the beautifully heart-breaking song “Two Doves” from Dirty Projectors, and Sufjan Stevens’ triumphant electronic track, “Too Much.”
Check out their entire playlist and COIN’s remaining spring tour dates below.
March 6 — Phoenix, AZ @ The Van Buren
March 9 — Los Angeles, CA @ The Fonda Theatre
March 10 — San Francisco, CA @ The Filmore
March 12 — Portland, OR @ Wonder Ballroom
March 13 — Vancouver, BC @ The Biltmore Vabaret
March 14 — Seattle, WA @ The Showbox
March 16 — Salt Lake City, UT @ The Depot
March 17 — Englewood, CO @ Gothic Theatre


Supreme Court rules in favour of Delhi Govt in tussle with Centre
Tags: State News
The Supreme Court on May 11 ruled unanimously in favour of the Delhi government on the issue of who controls the bureaucracy in the national capital.
An overview of the news
A 5-judge constitution bench headed by Chief Justice DY Chandrachud held that in Delhi (National Capital Territory), all powers relating to services and administration, except in areas outside the legislative powers, would rest with the elected government.
However, the authority of police, public order and land will remain with the Centre.
The court said that this decision would uphold the basic structure of federalism and democracy.
Background of the case
A five-judge constitution bench of the Supreme Court was hearing the dispute between theDelhi government and the central government.
The dispute was over matters relating totransfer and control over the overall functioning of administrative services in the National Capital Territory (NCT) of Delhi.
Administrative services include appointments and transfers in the national capital.
In 2018, a five-judge constitution bench headed by then Chief Justice Dipak Misra laid down broad principles governing relations between Delhi and the Center and ruled in favor of the Delhi government on most issues.
However, the important issue of service was left unresolved after two judges gave a split verdict in 2019.
After this the issue was referred to a three-judge constitution bench and then to a five-judge constitution bench, which has now settled it.
Highlights of the court verdict
A five-judge Supreme Court bench unanimously ruled in favor of the Delhi governmenton the issue of who has control over the bureaucracy in the national capital.
Earlier, the bureaucracy was controlled by the Lieutenant Governor, the Chief Secretary and the Secretary of the Services Department.
The Supreme Court unanimously ruled that the LG cannot have comprehensive administrative powers on all issues related to Delhi.
The LG's powers do not give him the right to interfere with the legislative powers of the Delhi Assembly and the elected government.
The posting and transfer of officers will be with the Delhi government.
Theelected government should have the right to administrative service.
The Lieutenant Governor will have to follow the advice of the government.
The authority of police, public order and land will remain with the center.
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Documentation of Indigenous African Musical Traditions in South Africa
This project involves the documentation of traditional music and its transcription into standard staff notation for preservation and use.
The preservation and study of indigenous African musical traditions are cultural priorities in post-apartheid South Africa. [Photo credit: Project organizer]
Location: South Africa, Southern Africa, Africa Organiser(s): Southern African Music Rights Organization Funder(s): U.S. Ambassadors Fund for Cultural Preservation Funding received: $88,179 (USD) Commencement Date: 09/2017 Project Status: CompletedProject owner? Update this project

domain: library


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Can't wait to try this recipe for Skinny Tuna Cakes! So light but filling at 112 calories per serving!VING this recipe for Skinny Tuna Cakes! So light but filling at 112 calories per serving!
Wild Rose D-Tox: meal plan. Here is ours: In preparation for this cleanse, read recipes, plan, make them once in order to see if you like them and what the prepar.
No-Bake Energy Bites Recipe 1 cup (dry) oatmeal cup toasted coconut flakes cup peanut butter cup ground flaxseed or wheat germ cup chocolate chips (optional) cup honey 1 tsp. (Just try not to eat the WHOLE Recipe!
Our assistant editor Dominique Lamberton said no to dairy, wheat and alcohol (on the Wild Rose D-tox) for 12 days and lived to tell the story.

domain: food


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This villainous Bond girl doesn't disappoint as she struts around in an one Bond Girl goes to Eva Green as Vesper Lynd in Casino Royale. But it's the alt Bond girl, the undercover bombshell who sizzles with a unique Sure, she's dressed to kill, per se, but the glitzy, chintzy ball gowns, wit who got away, but her chic, polished style in Casino Royale remains a. Bond Girls Style Evening Gowns are limited to formal evening dresses and proper It's the front of Eva Green's dress that's the most intriguing-" Casino Royale ". ADD TO BAG SAVE FOR LATER. Hilarious signs from around the world urge social media addicts to put down their phones It's written all over her face! Putting the sex into tennis! She uses the car in Haiti. James Bond Films Intros.
VideoEva Green - Casino Royale Extended Trailer - Quite a Good Line
Vorsichtig man: Casino royale dresses bond girl
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domain: entertainment


DMK members led by party floor leader stage a walk-out condemning heavy load shedding
The poor quality of drinking water supplied in some of the wards and allegations of negligence in initiating steps to prevent dengue in the city dominated the proceedings of the Corporation Council meeting on Friday, even as opposition Dravida Munnetra Kazhagam councillors staged a walk-out protesting the severe load shedding.
Independent councillor M.Venkatraj kicked up much dust displaying a bottle of discoloured drinking water, which he said was being supplied to his ward (no.34). The problem, he alleged, had been persisting for three months in his ward apparently after the corporation started supplying water pumped from the collector wells of the new drinking water augmentation scheme on the Coleroon river.
Water supplied to some households was reddish and some residents complained of itching after bathing in the water. One of the residents affected by dengue was from Subramaniapuram in his ward, he said and demanded urgent steps to ensure quality of water supplied to residents.
Corporation engineers who responded to his allegation said that they had already attended to the problem and tests on water samples with TWAD lab found no problem in the quality of water supplied. The initial flow could have been discoloured at a few places, they said.
Mr.Venkatraj was soon joined by a few other DMK councillors, who alleged that the same problem persisted in three or four wards. Some of the DMK councillors also charged the corporation with negligence in initiating steps to prevent dengue. This brought the AIADMK members to the feet, with J.Srinivasan of the party wondering why Mr.Venkatraj did not raise the issue for three months. Mayor A.Jaya directed the corporation officials to conduct an inspection to set right the problem, if any, immediately.
While urging the Mayor to look into the problem as councillors from three to four wards were raising the same complaint, M.Anbazhagan, DMK floor leader, urged the corporation to intensify measures to check the spread of dengue in the city. People with fever were getting admitted to various private hospitals and there was a need to sensitise the residents to ways to prevent breeding of Aedes mosquito.
Unruly scenes were witnessed after K.S.Nagarajan of the DMK attempted to raise the issue of severe load shedding in the city by pointing out that the AIADMK had come to power assuring to overcome the problem within a year. Amidst vociferous protests from AIADMK benches, Mr.Anbazhagan led a walk-out along with his party men condemning the power cuts.
K.Shankar of the DMDK suggested that the corporation explore the feasibility of installing solar-powered street lamps in the city in view of the heavy load shedding. Commissioner V.P.Thandapani said the government has sanctioned Rs.5.45 crore for installing LED lamps for street lamps in the city under Integrated Urban Development Mission. All street lamps in the entire zone would be fully converted into LED lamps utilising the fund, he said.


Blue-crowned Motmot (Momotus momota) - Recorded at Rancho Oropendola near Orotina (Costa Rica) - this bird repeats this "bark" every 5 seconds or so over and over. Motmots are beautiful birds with long, knob-ended tails, which they swing back and forth side-to-side like a pendulum. The tail feathers emerge without the "knobs", but the barbs abrade off quickly in the area a few cm proximal to the end, leaving a "knob" attached only by the shaft.
Douglas Von Gausig (recordist; copyright holder), Naturesongs.com
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License.
Help us improve the site by taking our survey.


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'It's not surprising that born-frees are racist': Experts weigh in on Miss SA saga
The n-word might be ubiquitous in rap, but that doesn't give everyone carte blanche to use it.
That was the warning this week from Wits University historian Hlonipha Mokoena after two Miss SA entrants saw their hopes crumble over teenage tweets containing the n-word.
When she was 14, it emerged on Tuesday, Bianca Schoombee used the n-word and repeatedly referred to women as "sluts" and "bitches".
On Wednesday, the 21-year-old stepped away from the 2021 pageant, and on Thursday she parted with modelling agency Sync.
Then social media sleuths found the n-word in posts from 2010 to 2013 by another entrant, Oneida Cooper, who said she would not yield to "cyber-bullying" by withdrawing from the competition.
"I wish nobody out there is subjected to the cruelty of what I've endured in the past few days," said Cooper, daughter of struggle veteran Sathasivian "Saths" Cooper, who was locked up for nine years during the apartheid era.
Cooper, 27, said the Covid-19 lockdown had given people more time to persecute others. "Tweets ... amongst my teenage girlfriends that have been circulated have been geared at presenting me in a negative light," she said.
I wish nobody out there is subjected to the cruelty of what I've endured in the past few daysMiss SA hopeful Oneida Cooper
"To have certain individuals trying to break down your race, your culture, your political stance from a few tweets is so unfortunate because it is far from the truth. It would be remiss of us ... to not believe that people can grow."
Schoombee initially agreed to speak to the Sunday Times, but yesterday changed her mind when the newspaper declined to sign a legal waiver.
Mokoena, from the Wits Institute for Social and Economic Research, said popular culture and social media had created "the false impression that the n-word is democratic and that any black person in the world can and does use it".
However, "only African-Americans can and should be allowed to use the word. As black South Africans, we have a country run by us, a constitution that we have written, and a set of rights which are every day protected by the law.
"African-Americans do not have that power and so the n-word is what in America they call 'fighting words'.
"Social media has unfortunately trivialised this word ... It should always be clear that the word will never be acceptable to use by anyone whose ancestors have never been hung from a tree. Period."
Other experts said it should not come as a surprise when the born-free generation expresses racism. Diversity and transformation specialist Dr Claire Kelly said oppressive systems, behaviour and attitudes did not stop with the end of apartheid, and people with a struggle history were not immune from racism.
"In general, white life is valued more than black life in SA, white culture is valued more, white aesthetics are valued more. So no, it is not surprising that the 'born-frees' are racist," she said.
"We mustn't think that people who were in the struggle or who have parents who were in the struggle are somehow exempt from these things. It's about perpetuating the narrative that white/light is superior and black/dark is inferior, and that happens in many different ways."
Language practitioner Cornelia du Plooy said words do not easily change their meaning no matter who uses them.
"It's not just about the intention behind the use of a word that's deemed offensive, it's about the place that word holds in society, the harm it's caused, that gives it more or less power," she said.

domain: news


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In my continued quest to not be so carb-crazy, I found THIS recipe that I thought sounded stellar. (I kind of like this girl’s blog in general. Check it out.) She didn’t give a ton of directions, but see what I did below:
- Grease a 2 quart casserole dish.
- Cover the bottom of the dish with pizza sauce.
- Top with…
- A few handfuls of fresh spinach
- 1/2 pound honey ham (Hy-Vee happened to have pineapple smoked ham!)
- Chopped red pepper
- Chopped red onion
- 4 oz sliced mushrooms
- 1 small can pineapple tidbits (drained)
- 1/2 cup of pizza sauce
- Crushed red pepper flakes
- Pizza-blend/cheddar cheese
- Cover and bake at 375* for 25 minutes. Remove the foil and bake five more minutes.
- Let rest for 5-10 minutes.
This was deeeeelicious but had too much liquid. Solution????? Don’t say “crust.” 🙂
2 thoughts on “Low Carb Crustless Hawaiian “Pizza””
possibly cooking the mushrooms some and maybe the pineapple some to get rid of the moisture. it could also be the sauce that you are using.
Good ideas! I put sauce in the bottom of the pan (re: lasagna), and I definitely didn’t need to do that under spinach! Thanks for stopping by!


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Surprising, deliciously quirky and amusing, this gem of a book is one to treasure. Quite literally climbing out of his window, one hundred year old Allan disappears on an adventure, but this isn't his first. Alternating between the present and the past is extremely entertaining, nothing is lost but everything gained in discovering what makes Allan, Allan! While he is one of the most captivating characters to ever appear in print, Allan accrues some truly fascinating travelling companions. You get the feeling that Jonasson really enjoyed writing this novel and let his imagination run riotous rings onto the page. This is a book for adults of any age, with a reminder that to reach a century you are likely to have some pretty remarkable stories to tell (if not quite to this level of creativity). This is most definitely a must, must read… and once you’ve read it, The Girl Who Saved the King of Sweden should be next on your list.
The film version of The Hundred-year-old Man Who Climbed Out of the Window and Disappeared was released in UK cinemas on Friday 4 July 2014. Click below to view the trailer.
|Modern and Contemporary Fiction


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Childhood obesity remains a major public health crisis for the nation and our region.
The incidence of obesity among children is staggering. During the past three decades, childhood obesity rates in America have tripled, and today, nearly one in three children in this country is overweight or obese. These children have a much higher risk of developing serious chronic diseases including cardiovascular disease, hypertension, diabetes and many cancers, which have long been associated with middle age. In fact, some experts are estimating that one in three of today's pre-adolescents will suffer from type 2 diabetes in adulthood.
During the past decade, the Highmark Foundation has taken a leadership position regionally in combating this epidemic and remains committed to funding programs that are sustainable, replicable and that achieve measurable outcomes.
The programs the Foundation has introduced fall into two major categories: physical activity and nutrition. Physical activity—in a variety of forms—has been a key element of the Highmark Foundation's plan to address the national health epidemic. To complement these efforts, the Foundation also supports the efforts of hundreds of school districts and other community-based programs that educate children and families about the benefits of healthy nutrition and eating habits.
Combined, these efforts have reached more than 1 million children and more than 1,500 schools across Pennsylvania, and we're still not done.
The Foundation remains committed to working toward change and prevention in the area of childhood obesity. Learn more about their goals and strategies to address this epidemic.More Details
The Highmark Foundation supports programs that work directly with children and adolescents to promote nutrition and healthy eating habits through behavior-focused strategies.More Details
The Highmark Foundation supports programs that work directly with children and adolescents to promote physical activity through behavior-focused strategies.More Details
See our approach to funding programs that address the well-being of familiesLearn More
See a complete list of grants in the community from the Highmark FoundationLearn More
Read the latest on the Highmark Foundations initiatives and grantmaking.Learn More

domain: medical


The Mavitec Fat Sterilizing system is an automated batch system which can be supplied with various capacities. It’s developed to work according to EU Commission regulation No. 142/2011 which implements EC Regulation 1069/2009.
The Fat Sterilizing system; charging, heating, pressurization, retention time, pressure release and discharging, is done in an automated cycle
Minimum human interference is required, while the required parameters are monitored and controlled
Process data are logged for quality control and veterinarian inspections
The process operates at a temperature more than 133° for at least 20 minutes at an absolute pressure of 3 bar, according to Method 1; Pressure SterilizationHigh pressure screw press


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Aims and scope
Publishing Research Quarterly is an international forum for the publication of original peer-reviewed papers covering significant research on and analyses of the full range of the publishing environment. The journal provides analysis of content development, production, distribution, and marketing of books, magazines, journals, and online information services in relation to the social, political, economic, and technological conditions that shape the publishing process, extending from editorial decision-making to order processing to print and online delivery.
Publishing Research Quarterly publishes significant research reports and analyses of industry trends, covering topics such as product development, marketing, financial aspects, and print and online distribution as well as the relationship between publishing activities and publishing’s constituencies among industry, government, and consumer communities. Scholarly articles, research reports, review papers, essays, surveys, memoirs, statistics, letters, and notes that contribute to knowledge about how different sectors of the publishing industry operate are published as well as book reviews.


McCaul to host a home ownership and foreclosure prevention event
Published 7:00 pm, Sunday, August 17, 2008
Congressman Michael McCaul, R-Austin, will host a home ownership promotion and foreclosure prevention event, Saturday Aug. 23 at the Katy Public Library.
It will bring together government and private resources to offer information and guidance to first time home buyers, veterans and current homeowners in today’s troubled housing market.
The resources are valuable tools for people to make informed decisions, whether they are trying to buy a home, maintain their mortgage or face foreclosure.
The meeting will be held from 2:30 p.m. until 4 p.m.
Experts and professionals from Housing and Urban Development-approved housing counselors, the HOPE NOW Alliance, the U.S. Department of Veterans’ Affairs, the Texas Veterans Land Board, and Texas Foreclosure Prevention Task Force will be on hand to help answer any questions during the meeting.
Home ownership and foreclosure meeting
Date:Saturday, August 23, 2008
Time:2:30 - 4:00 pm
Location:Katy Public Library, Community Room, 5414 Franz Rd., Katy, TX


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Randa is a prominent Australian author, academic, human rights advocate, former lawyer and mother of four children. She has been nominated for Sweden’s 2019 Astrid Lindgren Award, the world’s biggest children’s and young adult literature award (she was also nominated in 2018). The award-winning author of 11 novels published and translated in over 20 countries, Randa writes across a wide range of genres and actively seeks to translate her academic work into creative interventions which reshape dominant narratives around race, human rights, multiculturalism and identity in popular culture. She has been publishing her op eds in Australia’s national and international newspapers and journals since 1998. She has had regular appearances on Q&A, the Drum, Lateline and the 7.30 Report, and radio interviews (RN Drive, ABC Books and Arts, the Conversation Hour etc).
Mark is a writer, a community worker, a campaigner for social justice, and an author. He assists the oppressed, the persecuted and the marginalised to tell their stories. He uses his writing, his photography and other styles of media to motivate people to be the change they want to see in the world.


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The Power of Pause. How to be More Effective in a Demanding, 24/7 World
- Guilmartin Nance
- Международные стандарты финансовой отчётности (МСФО); Мотивация; Зарубежная деловая литература
- John Wiley & Sons Limited (USD)-double-299293-8
- PDF книга
- 258 стр
- Язык книги:
A clear, actionable plan to fight frustration at work, make savvier decisions, and avoid costly mistakes when we're short on time, attention, and choices One of the most frustrating dilemmas for working people today is how to be effective when we feel we don't have time or we're facing non-stop demands. The Power of Pause process is a dynamic practice that Nance Guilmartin has taught thousands of people worldwide, equipping them to regain control of thoughts and avoid miscommunications. This tested method helps readers to take a moment to wonder what's called for when we feel we're short on time, attention, temper, or choices. In that instant, we can use a simple method to rewire our overloaded circuits, tap into our «missing-in-action» common sense, and raise our communication intelligence. This process is not about slowing down the pace of workday life. It is about enabling anyone who is time-pressed to make savvier choices and avoid costly mistakes. Shows how to exercise leadership skills that save time and strengthen relationships Offers a process for learning to engage in productive exchanges rather than attacking or being resigned Enables managers and teams to save time and money Reveals how to fix problems and achieve goals with less stress The Power of Pause methods enable managers and teams across varying industries/any industry to save time and money, fix problems and achieve goals with less stress–even in the face of competition, cultural and language differences, or tight budgets.
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domain: psychology


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text:
Rallies in two Dutch cities as visiting Turkish minister is deported
The Turkish Family and Social Affairs Minister was deported to Germany, after Dutch authorities declared her an "undesirable alien" and stopped her within 30m of the Turkish consulate in Rotterdam on Saturday.
Published: March 12, 2017, 6:39 pm
Dutch NOS correspondent Robert Bas reported that the minister rejected the request by Dutch police to leave the country, after police refused to let her address a mass rally.
Riots broke out and Dutch police had to deploy a watercannon against the angry crowd, FWM learned. Dutch authorities denied it and described the situation as “stable”. Crowds of Turkish protesters had stoned law enforcement, as RTV Rijnmond spoke of a massive police presence on Westblaak, Rotterdam.
A SWAT team from the Dutch police was also called in as riot police cordoned off the area. The Dienst Speciale Interventies (DSI) surrounded the consulate. In Amsterdam too, angry Turkish rioters gathered on Damrak, waving flags.
Minister Fatma Betul Sayan Kaya was detained by police, local media reported, after which she was given a police escort back to the German border. Kaya was denied entrance to the Turkish mission in Rotterdam, RTL News reported.
“I will go to the consulate building. That is a building belonging to my country and I am a minister of that country. There is no such international practice. I don’t accept that decision, I reject it and I won’t return to Germany,” the minister said according to the Saily Sabah newspaper before being detained by Rotterdam police.
“We were stopped at the Consulate General of Rotterdam 30 meters away and were not allowed to enter,” Kaya tweeted. “Netherlands is violating all international laws, conventions and human rights.” Kaya accused the Dutch of “tyranny and oppression” in denying her access to the building.
As her car came to a halt, and the minister realised she would not be entering the consulate, she got out and started screaming, a source told FWM. The minister had remained in her armored BMW until a truck arrived to tow the vehicle. She then stepped out and was escorted back to the border by helicoptered police convoy.
Rotterdam’s mayor Ahmed Aboutaleb told Dutch news agency NOS that Turkish embassy staff had “mislead” him on the forthcoming visit of Kaya. The mayor claimed that the Turkish consul general told him nothing had been planned for the day.
“He outright lied,” Aboutaleb said, and added that he was angered by the comparison of Dutch authorities to “fascists”. Dutch and German authorities called off her campaign meetings ahead of a Turkish referendum on constitutional amendments.
“Minister Kaya is on her way to Germany, accompanied by police. Her car is being driven back. This also applies to her guards and employees,” he said. Kaya’s meetings in the Netherlands were scheduled to take place in Hengelo, Enschede and Wehl as well as in Cologne, in Germany but were cancelled due to “security reasons”.
Dutch Prime Minister Mark Rutte issued a statement calling the visit of the Turkish minister “irresponsible” and the “Nazi” slurs by Turkish authorities “unacceptable”. Rutte said the Dutch government repeatedly told their Turkish counterparts that Kaya was “not welcome in the Netherlands”, alluding to why his government prevented her from staging a pro-Erdogan rally outside the diplomatic premises.
The Turkish premier accused the Dutch government of “violating all diplomatic and international rules” by disregarding the minister’s immunity in a statement Saturday.
Meanwhile the European Union cancelled some EU integration funding for Turkey because the country “is moving away from Europe,” European Neighborhood Policy EU Commissioner Johannes Hahn said.
“Turkey is moving not in the direction of Europe, but in the opposite direction. We are legally obliged to correlate financial support with the progress the country is making,” Hahn told DPA news agency.
He suggested that the Erdogan regime is ignoring “not only the EU standards but the international law as well”.
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WarsawIn Poland, a change in the law on asylum has come into force, according to which migrants entering the country illegally can more easily be expelled. The background to this is a sharp increase in the number of illegal entries via Belarus.
ParisFlorian Philippot, the leader of the Patriots party in France, targeted "Macron and his clique who have misled the state, even more than their sinister predecessors". But Philippot does not have the same voter allure as Marine Le Pen or Eric Zemmour.
BerlinMostly claiming the old and very sick, there has been a notable trend of promoting iatrogenic treatment (where the cure was worse than the disease) including excessive use of invasive mechanical ventilators and ineffective and expensive Big Pharma drugs like Remdesivir to treat a pandemic allegedly created by a "bat" from Wuhan in China.
Antwerp In Antwerp, Belgium, rappers display their violence in videos and call for robberies and knife attacks. These young people do what is called “drill”, a musical sub-genre of hip-hop launched in the late 2000s by young rappers and producers from the South Side neighborhoods of Chicago. The drill is characterized by lyrics with violent, morbid, dark content and an irregular rhythm.
BerlinDoubts about official SARS-CoV-2 figures from the German government have increased: Almost half of the country fear an eternal Corona dictatorship.
BrusselsWith the help of Big Data and new technologies, NATO intends to change not what people think, but how they think. And thus "to make everyone a weapon".
LondonBritish Prime Minister Boris Johnson invited around 20 business people to dinner in London on Monday, including Bill Gates and Jamie Dimon, the boss of JPMorgan Chase. Together with these individuals, Johnson wants to build a “Global Britain”.
StockholmIn the Sweden Democrats, a heated discussion has flared up after a Member of Parliament Roger Richthoff, who is also a regular member of the Defense Committee, attracted attention in the media for critical comments about Covid-19 vaccination.
BudapestIn the spring of 2022, the Hungarian opposition believe they will have the opportunity to defeat Viktor Orban, who has been in power since 2010.
Meteorologists are warning of an extremely cold and snowy winter. The amount of snow in the northern hemisphere is already hundreds of gigatons larger than normal for the season and the South Pole has measured the coldest winter ever since measurements began there. This is astonishing climate news that the system media has chosen to completely ignore.


Water, Life Cannot Exist Without It
Water is the world’s most natural resource and without it there would be no life on earth. Nature limits our available supply of water. Virtually all of human uses require fresh water. 97% of the Earth’s water is salt water and only 2.5% is fresh water of which over two thirds is frozen in glaciers and polar ice caps. The unfrozen freshwater is mainly ground water with only a fraction on the surface. Fresh water is a renewable resource but the world usage of clean water is resulting in a steadily decreasing supply. There is a process know as Desalination which is an artificial process by which saline water (sea water) is converted into fresh water. This process is known as reverse osmosis. This process is very expensive and very little human use is satisfied by desalination.
As the world population rises at an unprecedented rate, areas that are experiencing imbalances in supply and demand increases. Water scarcity contributes to instability of regions by depleting the health of a population and obstructing economic development. This effect on regions has been termed “Water Stress”. Water stress, according to the World Business Council for Sustainable Development, applies to situations where there is not enough water for all uses, whether agriculture, industrial or domestic. Defining thresholds for water stress is determined by a complex, entailing assumption about water and its efficiency. The factors used to determine the level of water stress that hampers economic development and human health are population growth, increased affluence, and expansion of business activity, rapid urbanization, and climate change, depletion of aquifers, pollution and water protection.
The water cycle itself is important in understanding how this precious natural resource renews itself, but as mentioned earlier fresh surface water (or ground water) is what keeps life going. Usable freshwater is relatively scarce and only represents about 3% of all water on Earth. Ground water begins as precipitation that infiltrates into the surface soil and rock. Some water that infiltrates will remain in the shallow soil layer. Eventually it might enter a stream or lake on the surface and some may infiltrate deeper, recharging ground-water aquifers. If aquifers are shallow or porous enough for water to move freely through a well can be drilled for use of the water.
The health and economic effects of a shortage of clean water is of great concern and has resulted in the evolution of the science “Hydrology” to understand the complex water system of the earth and help find solutions to problems we are facing. Hydrologists study the fundamental transport process to describe the quantity and quality of water as it moves through the cycle (evaporation, precipitation, stream flow, infiltration, groundwater flow, and other components. Engineering hydrologists or water resources engineer is involved in the planning, analysis, design, construction and operation of projects for the control, utilization and management of water resources. Meteorologists, oceanographers, geologists, chemists, physicists, biologists, economists, political scientists, specialists in applied mathematics and computer science, and engineers in several fields are also concerned and involved in a solution to water resources problems. The scientific community has taken a closer look at the “Water Cycle” which is the existence and movement of water on, in, ad above the Earth. Water is always in movement and changing states from liquid to vapor to ice and back again. The water cycle has no starting point, it just continually cycles.
The Universities Council on Water Resources conducted a study of estimated water use in the United States and determined that in 1980 water use in the United States was estimated to be an average of 450 million gallons per day, a 22% increase from 1970 estimate. Average per capital use was 1,600...
References: West, L, Your Guide to Environmental Issues “Global Water Supply Drying Up as Population Grows” http://environment.about.com/od/biodiversityconservation/a/watersupply.htm.
Water Conservation Tips, Household Hints to Conserve Water and Money, http://www.monolake.org/waterconservation/
Climate Change – Health and Environmental Effects, Water Resources/Climate Change- Health and Environmental Effects/U.S. EPA http://www.epa.gov/climatechange/effecrts/water/index.html
Hydrology, The Universities Council on Water Resources (UCOWR) Organization. http://www.uncowr.siu.edu/about.html
U.S. Geological Survey: The Water Cycle http://ga.water.usgs.gov.edu/watercyclesummary.html
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Isuzu Philippines Corp. imposed its authority in diesel engine production as it showcased its products at the first Philippine Boat Show.
Beyond engine production for trucks and light commercial vehicles, Isuzu likewise specializes in powerplants with marine applications.
"Isuzu has long had the expertise in the design and assembly of marine engines. I have no doubt that Filipino pleasure boat owners will be fascinated by the long roster of benefits that our marine engines offer," Isuzu Philippines president Keiji Takeda said.
Isuzu has been manufacturing marine engines for the commercial boat industry for over 60 years. It has gained popularity among boating enthusiasts due to its reliability, cost efficiency, and clean emissions. Isuzu also said its marine engines are easy to maintain and spare parts are readily available nationwide. Isuzu also offers on-call technical support to customers.
Isuzu Philippines displayed its 115ps four-cylinder UM4JB1TCX and its 230ps six-cylinder UM6BG1TC marine engines at the boat show, which may be used for light boats, fishing vessels and pleasure boats.
"Whether on land or out in the sea, trust Isuzu to propel you toward your destination," Takeda said.


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The World Today for September 06, 2023
NEED TO KNOW
Cracks in the Tent Pole
For the past 25 years, pundits in the West have been issuing dire warnings about China’s economy surpassing that of the United States, a shift that they feared would herald a new China-led global geopolitical system.
Today, however, China’s economy – the second largest in the world – is stalling. Now pundits are wondering whether it might collapse and trigger other worldwide effects. “Instead of marveling at China’s prosperity miracle, economists are now pondering whether China’s woes will bring down other parts of the global economy,” wrote Yahoo! Finance senior columnist Rick Newman.
Describing the Chinese economy as a “ticking time bomb,” the BBC noted how economic growth has slowed, youth unemployment has hit record highs, foreign investment has dropped off a cliff, exports are weak, the currency is weak, and, perhaps most importantly, the real estate sector is in crisis.
The Chinese government flooded the property sector with cash over the last few decades. Today, 70 percent of Chinese citizens’ wealth is tied up in real estate, Reuters explained.
But, as the empty, half-built apartments and commercial complexes that dot China attest, some of that money was wasted. Harsh coronavirus lockdown rules further undermined the sector. Low population growth means things won’t likely improve anytime soon. The central government recently imposed new rules that aimed to constrain lending and contain the crisis. They likely made it worse, though, in part because China’s communist-run financial system is corrupt and inflexible.
Massive real estate developer Country Garden, for example, is now facing default on its debts after suffering a $6.7 billion loss in the first half of the year, added Newsweek. Observers fear the company could become another Evergrande, which has lost 99 percent of its share value in the last three years while owing creditors almost $330 billion, as the Guardian outlined.
In early September, Chinese officials announced new measures to help. They cut minimum down payments for mortgages to 20 percent for first-time homebuyers and 30 percent for second-time homebuyers, wrote CNN. Forty percent down payments were previously the norm. Officials also slashed mortgage rates to boost lending and investment.
Publicly, however, Chinese leaders have broadcasted optimistic propaganda to push back against the sense of doom and gloom that pervades the country, reported the New York Times. They also decided not to publish new statistics on youth unemployment and other trends that might embarrass Chinese President Xi Jinping, who has accumulated more power during his rule than any other Chinese leader, according to Time magazine.
That is harming the Chinese economy, say analysts.
“The government’s pursuit of total control has set the country on a path of slower growth and created multiplying pockets of dissatisfaction,” Ian Johnson, a senior fellow at the Council on Foreign Relations, wrote in Foreign Affairs. “These economic problems are part of a broader process of political ossification and ideological hardening … it is difficult to miss the signs of a new national stasis.”
At the same time, China has become “uninvestable” for foreign investors because it is too risky, especially in light of raids on foreign businesses, exit bans of executives and “opaque” penalties, wrote the Washington Post.
“China needs to recognize that they can no longer rely on the sheer mass of their market to attract that type of foreign investment,” Naomi Wilson, vice president of policy, Asia and global trade at the Information Technology Industry Council, told the Post. “Even among Chinese companies, there have been efforts to relocate outside of China.”
The country that used to be the tent pole for the global economy is snapping.
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text:
Includes bibliographical references.
|Statement||by James Boyd White.|
|Series||Legal theory workshop series -- WSVI-11|
|Contributions||University of Toronto. Faculty of Law.|
|LC Classifications||K235.L46 .W54|
|The Physical Object|
|Pagination||67 p. ;|
|Number of Pages||67|
The debate over judicial review typically frames law's meaning as either rigid or elastic, strictly given or subjectively interpreted. By examining the operation of the wider legal system this book provides a new framework for understanding objective judicial review.5/5(12). Judicial Review and Contemporary Democratic Theory begins with an assessment of the empirical and theoretical flaws of this framework, and an account of the ways in which this framework has hindered meaningful investigation into judicial review’s value within a democratic political system. To replace the counter-majoritarian difficulty framework, Scott E. Lemieux and David J. Watkins draw on recent work Author: Scott E. Lemieux, David J. Watkins. Madison and Hamilton would be appalled. Peter Wallison, in Judicial Fortitude, gives us numerous examples. Foremost among these, is the Dodd-Frank Act and its pernicious spawn the Consumer Financial Protection Bureau (CFPB). In his previous book, Hidden in Plain Sight, the author gave us an explanation of the cause of the financial crisis/5(14). This book is the outcome of the 20th General Congress of International Academy of Comparative Law and deals with the judicial deference to the administration in judicial review which is a concept and legal practice that is present to a greater or lesser degree in every constitutional system.
This collection of essays presents opposing sides of the debate over the foundations of judicial review. In this work,however, the discussion of whether the 'ultra vires' doctrine is best characterised as a central principle of administrative law or as a harmless, justificatory fiction is located in the highly topical and political context of constitutional change.3/5(1). Judicial review is the power of courts to decide the validity of acts of the legislative and executive branches of government. If the courts decide that a legislative act is unconstitutional, it is nullified. Judicial Review in New Democracies: Constitutional Courts in Asian Cases think so. Certainly, rights and the spread of rights consciousness would play a certain role in explaining the spread of constitutional review but it is ineffective to explain why we see constitutional review in . the power of judicial review and it is unquestionably, to my mind, part of the basic structure of the Constitution”- Justice Bhagwati Introduction: Judicial Review basically is an aspect of judicial power of the state which is exercised by the courts to determine the validity of a rule of law or an action of any agency of the Size: KB.
What is judicial review? It is a means of questioning the lawfulness of decisions made by public bodies, such as local councils, government departments, police forces or health authorities. A book of authorities must be served on the respondents, the Tribunal and the Attorney General before the hearing of your application for judicial review. Often it is filed when the application is perfected but it does not technically need to be filed at that time. Buy Judicial review books from today. Find our best selection and offers online, with FREE Click & Collect or UK delivery. Keeping Legal History "Legal" and Judicial Activism in Perspective: A Reply to Richard Pildes By Heckman, Charles A Constitutional Commentary, Vol. 19, No. 3, Winter Read preview Overview Judicial Legislation: A Study in American Legal Theory By Fred V. Cahill Jr Ronald Press,


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I can never resist these old horsehair drafting brushes; I just love the form, and they make dusting off the desk or work table a pleasure. Hang it from a ribbon in the office or studio both to be used as needed and enjoyed the rest of the time! This one reads "100% Sterilized Horsehair No. 3510 Made In USA" on one side.
This brush has been used and there is wear to the wood particularly on the back side, but the bristles are in great shape and it remains a very lovely and useful thing. 13 1/4" long x 3 3/4" wide x 5/8" deep.

domain: hobby


Central Australia renal accommodation project
On 22 June 2015, the Commonwealth and Northern Territory Government entered into a $10 million agreement for the delivery of family-centric renal accommodation in Alice Springs and Tennant Creek, along with infrastructure for dialysis facilities and subsequent staff accommodation in Kaltukatjara, Papunya and Mount Liebig.
Central Australian Affordable Housing Company (CAAHC) was awarded the tender to refurbish and manage a total of ten homes - eight in Alice Springs and two in Tenant Creek. CAAHC started the construction and upgrade work on the houses in August 2016. The work was completed in June 2017. CAAHC will provide property and tenancy management of the dwellings to eligible tenants for a minimum of ten years from the completion date.
The construction of new renal clinics and three-bedroom renal nurse accommodation in Kaltukatjara and Papunya started in March 2017, and all work was completed in September 2017. The dialysis clinic upgrade work at Mount Liebig also started in early 2017 and was completed in November 2017.
Last updated: 13 August 2019


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Tuning the Violin
The violin is usually tuned by striking, one at a time, the four
notes on the piano that correspond to the four violin strings,
and then twisting the tuning pegs until each string gives the
correct tone or pitch. Fig. 60 shows the piano notes that cor-
respond to the violin strings, and also the position on the musi-
cal staff of the note made by each string.
Always tune the A string first; then the D string; then the
G string; and finally the E string.
To start tuning, hold the violin upright, scroll on top, grasp-
ing the neck with your left hand. Play A on the piano with
your right hand; then pluck the A string with your left thumb.
If the string sounds higher than the piano note, loosen it by
turning back the tuning peg until the string sounds a little
lower than the piano. Strike A on the piano again to get the
exact pitch. Then tighten the string again very slowly, pluck-
ing it with the left thumb as you do so. As soon as the string is
tightened so it sounds exactly like the A on the piano, it is
tuned. If a peg is too slippery to hold tight, chalk it with chalk
that you can get at your music store.
The most important thing about tuning is always to finish
tuning a string with a tightening motion of the tuning peg. If
you finish with a loosening motion of the peg the violin will
get out of tune almost as soon as you start to play.
Tune the D string next in exactly the same way.
Then hold the neck of the violin with your right hand, while
you tune the G string and E string. Pluck the strings with your
right thumb, and turn the pegs with your left hand. Always
tune the E string very slowly because it is under high tension.
Use the E string adjuster when the tone of the string is almost
If a piano is not available, you can tune your violin with a
pitch pipe, which can be bought at any good music store.
(Fig. 60.) It consists of four blow pipes pitched G-D-A-E, to
which the four strings of the violin are tuned. You simply
blow into the pitch pipe instead of playing the notes on the


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|Event benefits animal shelter|
Garry Lawyer and Gerald Geisert (left) serve refreshments to attendees of the annual wine tasting event to benefit the Perkins County Animal Shelter held at the Perkins County Fairgrounds on Saturday, April 13.
Dr. Shannon Jensen (left) checks in with her Perkins County Animal Shelter staff, Janice Owens and Jessica Bollinger, who accepted admission fees and passed out wine glasses and bidding numbers for the auction throughout the evening. Approximately 100 people attended the fundraiser to benefit the no-kill shelter located on the south edge of Grant. Some good news is that a cat named Shamrock, who was featured in last week’s issue of the Tribune as having been in he shelter over a year, has since been adopted.
Shown in the background as part of a slide show featuring 500 photos is one of the animal shelter’s residents who is seeking a home. Those in attendance were treated to many delectable hors d’oeuvres, various wines and other beverages. Both a live auction and silent auction were held to also help raise funds for the shelter which is currently housing 10 dogs and seven cats. Five more dogs are scheduled to arrive this week. (Photos by Shari Friedel)

domain: pet


text:
Olivia Culpo thinks she looks ''a little scary'' when she wears too much make-up, and much prefers the way she looks when she doesn't have a face full of make-up on.
Olivia Culpo thinks she looks ''a little scary'' when she wears too much make-up.
The 25-year-old model has admitted she prefers to wear less cosmetic products on her face because she thinks she looks frightening when she goes overboard with her beauty products.
Speaking to Us Weekly, the brunette beauty said: ''I would rather have too little make-up on than too much because I think I look a little scary with too much on.''
And the style icon feels her best when she is on holiday.
She added: ''When I'm on vacation with healthy, dewy glow and beachy hair.''
Although Olivia - who is currently dating Danny Amendola - doesn't like to apply too many beauty products, she has admitted she has ''a lot'' of lipstick products.
She said: ''I like a lot of liners from MAC, Charlotte Tilbury and Marc Jacobs.I also love NARS lip crayons and Burt's Bee's chapstick -- it's really good. I try to play with my lips every single day and I can't leave the house without anything on them.''
And the star has revealed her secret behind her flawless complexion is that she undergoes facials and ''infrared therapy''.
She explained: ''I love getting facials and doing infrared therapy. It gets rid of breakouts and stimulates collagen too.''
Olivia recently received the Revolve Award for Beauty Influencer of the Year, and she has admitted she is ''very flattered'' to have picked up the gong because she does her best to ''inspire'' people with her social media platforms.
She said: ''Being nominated for the Revolve Award for Beauty Influencer of the Year is very flattering. I love being able to use my platform to inspire people to feel good about themselves in the beauty and fashion space. There are definitely times where I don't want to post something because I know it will shock my followers, but I've gotten better about letting that go and letting there be a learning curve. It's important to show people new things, take risks and be different.
''I enjoy posting a sexy picture every once in a while and celebrating my body makes me feel good, but I don't think I could ever do a post that is totally nude.''
From their newest EP 'What Did You Think When You Made Me This Way', Nothing But Thieves drop the lyric video for their single 'Take This Lonely...
The Lumineers honour their friend and hero Tom Petty with a sensational cover of his 1996 song 'Walls' from the 'She's the One' soundtrack.
Watch Olly Murs get his nerd on as he blags his way into an exclusive Snoop Dogg party (where Rowan Atkinson is the bartender) in the video for their...
From 'Happy' to 'Banana Pancakes', these are soaked in positivity.
Mariah Carey is the picture of glamour in the black and white video for her brand new single 'With You'. It's the lead single from her forthcoming...
Eminem draws attention to the negative response his 2017 album 'Revival' received in the video for his latest song 'Venom'; a song recorded for the...
With the recent release of her third, very well received album 'Hunter' just behind her, Anna had plenty of relatively new songs to showcase.


text:
Heaven on Earth Treats
Indulge into combination of therapies that are tailored to suit your skin type and
spa ritual packages that justify your ultimate spa experience.
Based on various oriental, western and acupressure techniques, Heaven on Earth brings
to you stress-releasing body treatments that reduce shortening of the muscles, improve
posture, balance, relax body alignments etc.
Deep Tissue Massage • Lomi Lomi • Aroma Therapy • Thai Massage

domain: health


text:
H.Res.551 - Providing for the consideration of the bill (H.R. 4618) to provide emergency assistance to American farmers and ranchers for crop and livestock feed losses due to disasters and to respond to loss of world markets for American agricultural commodities.105th Congress (1997-1998)
Subject Terms Assigned to H.Res.551 — 105th Congress (1997-1998)
Links from terms open lists of other bills and resolutions to which the term has been assigned. Find Bills by Legislative Subject and Policy Area provides research guidance. View all Legislative Subject Terms for this Congress.

domain: economics


Some people who have Parkinson's Disease, Motor Neurone Disease, Arthritis or other muscular skeletal problems, may have trouble turning from side to side in bed.
The Turn Yourself Sheet may help these people with limited strength but good mental ability, as the Turn Yourself Sheet will reduce the friction under the shoulders and hips when turning. This special breatheable sheet is placed on the bed and stays in position with a very strong breatheable foam that will withstand commercial washing.
The Turn Yourself Sheet is laid on the bed with the special foam pad face down and with the Sheet spread out either side of the foam section. Position the Sheet with the top part just under the pillow to ensure it is under the person's shoulders.
The bottom part will then be under the person's thighs, ensuring the hips will also be on top of the Turn Yourself Sheet. This product can be used on any size bed. Most people sleep directly onto the breatheable fabric, but a small cotton sheet can be placed on it if desired.
When turning in bed the person can use their legs to start turning or may even use their arms as well. The top layer of the Turn Yourself Sheet will move under the person reducing the normal friction under the body.
The surplus material that is on either side of the foam pad, will slide under the person as they turn, leaving a little of the material in front of them, but with surplus material behind them. When they turn again, onto either their back or onto the other side, the surplus material that was behind them will pass under them during the turn.
Some patients with disturbed sleeping habits may make the foam section curl over during the night. This should not impede any turning or pressure care, though it will look untidy in the morning. Care must be taken when getting in and out of bed to avoid slipping.
Also see the Pelican Slide and Turn Sheet.
Washing: For a longer lifespan, wash at 65° for 45 minutes. Do not use chlorine bleach or fabric softener. We suggest using Hydrogen Peroxide or Peracetic Acid. Air dry in shade or cool tumble dry. Never place in a hot drum. Nylon fabrics can suffer with rapid changes in temperature. Increase and decrease the washing and drying temperatures in stages. Excessive heat may damage the yarn and cause shrinkage.
For more infection control, machine wash up to 80°, making sure to increase and decrease the temperatures in stages.
For thermal disinfection, the following temperatures are suggested
- 5 minutes @ 80°C
- 8 minutes @ 75°C
- 10 minutes @ 70°C
- 12 minutes @ 68°C
- 15 minutes @ 60°C
For further information about the Turn Yourself Sheet visit Pelican Manufacturing at www.pelicanmanufacturing.com.au
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(Compiled by L. Renee Faust Rohe (3L))
Kenneth D. Ackerman, The Surprise Election and Political Murder of President James A. Garfield. Carroll & Graf, 2003.
Charles E. Rosenberg. The Trial of the Assassin Guiteau : Psychiatry and the Law in the Gilded Age. University of Chicago Press, 1995.
James C. Clark. The Murder of James A. Garfield : The President's Last Days and the Trial and Execution of His Assassin. McFarland & Company, 1993.
United States v. Guiteau, 1 Mackey 498 (D.C. Cir. 1882)
United States v. Guiteau, 1 Mackey 563 (D.C. Cir. 1882)
United States v. Guiteau, 1 Mackey 585 (D.C. Cir. 1882)
United States v. Guiteau, 10 F. 161 (D.N.Y. 1882)
Guiteau Collection: Folder Listing
The Charles J. Guiteau Collection consists of correspondence, affidavits and printed material by and about Guiteau, the notorious attorney who assassinated U.S. President James Abram Garfield on July 2, 1881. The assassination resulted in one of the most celebrated American "insanity trials" of the nineteenth century, which became something of a legal milestone in the judgement of the criminally insane.
Washington, D.C.--The Attack on the President's Life, The Arrest of the Assassin, Sketches by artists A. Berghaus and C. Upham,
1881. Scene in the ladies' room of the Baltimore and Ohio Railroad depot--The arrest of the assassin / from sketches by our special artist's [sic] A. Berghaus and C. Upham.
Illus. in: Frank Leslie's illustrated newspaper, 1881 July 16, pp. 332-333.
Comment of Charles Guiteau, two weeks before shooting President Garfield, From evidence given at Guiteau's Trial, John K. Porter's Closing Speech to the Jury in the Guiteau Trial, January 23, 1882.
The American Presidency
An unsuccessful lawyer, evangelist, and insurance salesman, Guiteau believed Garfield owed him a patronage position in the diplomatic corps, and that the president's political decisions threatened to destroy the Republican Party. Guiteau was convicted of murder and hanged on June 30, 1882. In 1883 Congress passed the Pendleton Act; it sought to reform civil service and limit the number of patronage seekers like Charles Guiteau.
Letter to a Jailer
On December 31, 1881, Charles Guiteau, the assassin of President James Garfield, wrote a New Year's greeting to his jailer.
WRHS Collections Catalog Online
The Western Reserve Historical Society's Collections Catalog is now available online!
"Charles Guiteau" the folksong
My name is Charles Guiteau, my name I'll ne'er deny.
I leave my aged parents in sorrow for to die.
But little did they think, while in my youthful bloom,
I'd be taken to the scaffold to meet my earthly doom.
Biography of James Garfield
the twentieth President of the United States (1881).
White House Biography - 23.9KB
Mortally wounded, Garfield lay in the White House for weeks. Alexander Graham Bell, inventor of the telephone, tried unsuccessfully to find the bullet with an induction-balance electrical device which he had designed. On September 6, Garfield was taken to the New Jersey seaside. For a few days he seemed to be recuperating, but on September 19, 1881, he died from an infection and internal hemorrhage.
National Park Service: James A. Garfield
Information on the National Historic Site

domain: history


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Now that the first NVIDIA Kepler graphics processing unit is officially available as part of the GeForce GTX 680 graphics card, the rumor mill is looking in the direction of its as yet unreleased peers.
The folks at 3DCenter.org
are the ones who posted information on the graphics chip that will power the GeForce GTX 660 graphics board, and probably one or more others too.
Called GK106, the GPU is built on the 28 nm manufacturing process (this was obvious, all Kepler chips use this technology) and has a die -area of 210 square millimeters.
Two Graphics Processing Clusters (GPCs) are present, along with four Streaming Multiprocessors (SMXs) and 768 CUDA cores.
Furthermore, the GPU boasts 64 TMUs, 24 ROPs and a 192-bit GDDR5 memory interface (cards will feature 1.5 GB or 2 GB of such VRAM).
Furthermore, PCI Express 3.0 is fully supported and the TDP (thermal design power) of a whole video board should be of around 130W.
All in all, the GK106 Kepler graphics chip, when used in desktop add-in boards, will have a performance on the same level as AMD's Radeon HD 7800 series, or the previous-generation HD 6950 (or NVIDIA's own GeForce GTX 560 Ti).
Finally, the price of the GeForce GTX 660 will be of under $200 (152-200 Euro).
Essentially, there should be a clear difference between the GK106 and the GK104
, which we talked about last week.
That one will power the GTX 670 Ti and will lead to prices of $349-399 (266-304 Euro, according to exchange rates). Needless to say, the specs are clearly a notch or two above the ones listed here.
Nevertheless, neither of these is anywhere close to the GK110
, expected to land in the GeForce 700 series later this year. Of course, this isn't really a fair comparison. GK110 wipes the floor with the GK104 too, after all.


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Sportmix Dog Food Review Sportmix Wholesomes Dog Food receives the Advisor’s second-highest tier rating of 4.5 stars.
What dog food brand is killing dogs?
A pet food recall is widening after the Food and Drug Administration announced that more than two dozen dogs died after eating Sportmix brand dry kibble. The statement issued on Monday said that the suspect is aflatoxin, a byproduct of a corn mold Aspergillus flavus, which at high levels can kill pets.
What company makes wholesome dog food?
SPORTMiX® Wholesomes™ supplies your pet with a naturally preserved and 100% complete and balanced diet. Made without high-moisture protein sources or common grains, Wholesomes™ now offers three grain-free and gluten-free formulas in addition to the original line of pet foods.
Is Sportmix wholesome recalled?
Midwestern Pet Foods, Evansville, Indiana is issuing a voluntary recall of specific expiration dates of certain dog and cat food brands including CanineX, Earthborn Holistic, Venture, Unrefined, Sportmix Wholesomes, Pro Pac, Pro Pac Ultimates, Sportstrail, Sportmix and Meridian brands produced at its Monmouth, Illinois Mar 26, 2021.
What is the healthiest food brand for dogs?
Top Healthy Dog Food Picks Nature’s Logic Sardine Meal Feast. Merrick Grain Free Dog Food. Taste of the Wild. Blue Buffalo. Canidae All Life Stages. Canidae Grain-Free Pure. Wellness Core Natural Grain Free. Diamond Naturals.
What are the worst treats for dogs?
Here are the worst dog treat brand for 2019. Ol’ Roy® Basted Biscuits Dog Treats. Purina® ALPO Variety Snaps Dog Treats. Canine Carry Outs® Beef Flavor Dog Treats. Pup-Peroni® Dog Treats. Purina® Beggin’ Strips Dog Treats. Purina® Beneful Baked Delights Dog Treats. Pedigree® Marrowbone Dog Treats. Pup Corn® Dog Treats.
What is the best dog food in the UK?
The Best Dry Dog Food Brands in the UK Lily’s Kitchen Complete Nutrition Dry Dog Food. Pure Dehydrated Dog Food. Tails.com Personalised Kibble. Arden Grange Adult Dried Dog Food. Harrington’s Complete Dry Dog Food. Orijen Adult Original Dry Food. James Wellbeloved Naturally Healthy Light Kibble.
Is SPORTMiX safe now?
UTAH (ABC4) – The U.S. Food and Drug Administration (FDA) has issued a recall warning of a Midwestern Pet Foods product, SPORTMiX, after discovering toxins in the food. The recall was issued after the consumption of SPORTMiX was linked to the death of at least 130 pets and more than 220 pet illnesses, the FDA reports.
Is Grain Free bad for dogs?
According to a warning from the Food and Drug Administration released last week, grain-free food might be giving dogs a life-threatening heart problem called dilated cardiomyopathy, or DCM. The science is still preliminary, and it’s based on a potential association between diet and heart disease in fewer than 600 dogs.
Is SPORTMiX good for dogs?
The SportMix Wholesomes dry dog food recipes consists of 49% carbohydrates, 29% fats and 22% protein and is a great dietary solution for your dog’s daily nutrition requirement. When looking for a good quality dog food, you must surely consider trying SportMix.
Is SPORTMiX dog food killing dogs?
More than 110 dogs have now died and more than 210 are reported as sick after eating recalled Sportmix pet food products, according to the U.S. Food and Drug Administration.
Is SPORTMiX dog food made in China?
SPORTMIX sources all ingredients from US suppliers if ingredients are available, grown or produced in the US. Certain subparts of the vitamin premixes are only available overseas but rest assure their US supplier makes every effort to source from reputable non-Chinese vendors. Sep 21, 2021.
What dog foods contain aflatoxin?
The brands affected are Triumph, Evolve, Wild Harvest, Nurture Farms, Pure Being and Elm. All of the dog foods have a best if used by date of Feb. 11, 2022.
What dog food is most recommended by vets?
10 Vet Recommended Dog Food Brands That Are Inexpensive (2021) Hill’s Science Diet. Royal Canin. Purina ProPlan. Orijen. Wellness Natural Food for Dogs. Castor & Pollux. Iams/Eukanuba. Nutro Ultra.
What is the purest dog food?
Here are The Dog Food Advisor’s best dry dog foods for December 2021. Wellness Complete Health Dry Dog Food. Instinct Original Grain-Free Dry. Nature’s Logic Dry Dog Food. Blue Buffalo Life Protection Dry. Canidae Grain-Free Pure Dry Dog Food. Orijen Dry Dog Food. Diamond Naturals Dry Kibble. Nulo Freestyle Dry Dog Food.
What can I feed my dog instead of dog food?
Refrigerator Plain, low-fat Greek yogurt. Mild cheeses, such as American. Cooked white or sweet potatoes. Cooked eggs, such as scrambled eggs. Rotisserie chicken, skin and bones removed. Cooked lean meat, such as chicken, beef, or turkey. Cooked or raw fresh vegetables, such as carrots, corn, and broccoli.
What dog treats do vets recommend?
Zuke’s Mini Naturals Chicken Recipe Dog Training Treats. Greenies Regular Dog Dental Treats. Three Dog Bakery Crunchy Beg-als. Riley’s Organic Coconut & Pumpkin Bone Dog Treats. KONG Easy Treat Peanut Butter Flavor. Wholehearted Boundless Bars Chicken With Mixed Berries.
Are Milk Bones bad for your dog?
If given in moderation (and if your dog is not allergic to the ingredients), Milk-Bone should not have adverse effects on your dog’s health. The occasional Milk-Bone may even have positive effects on your dog’s health. For instance, Milk-Bones can freshen breath and clean teeth.
Are bakers bad for dogs?
it contains various sugars. It actually contains more sugar than most dog foods on the market. Although sugar is vital to your dog’s health, too much sugar is very bad. The level of sugar in Bakers could explain the complaints of hyperactivity from some dog owners.


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By Bane Rossi
Tue, Aug 8
Tournament Field Also Includes Houston, North Texas, St. John’s, Towson, Utah & Wake Forest
CHARLESTON, S.C. – ESPN Events has announced the pairings for the 2023 Shriner’s Children’s Charleston Classic, and the University of Dayton Flyers will face the LSU Tigers in the first round on Nov. 16.
The tournament is a three-games-in-four-days event played on Nov. 17, 17 and 19 at TD Arena in Charleston, S.C.
The first-round schedule on Nov. 16 will be North Texas against St. John’s at 1:30 p.m. ET, Dayton vs. LSU at 4 p.m. ET, Houston vs. Towson at 6:30 p.m. ET and Utah taking on Wake Forest at 9 p.m. ET.
UD’s second game of the weekend will be against either North Texas or St. John’s.
The Shriner’s Children’s Charleston Classic will mark the 16th consecutive exempt tournament in a full-season schedule for UD, giving the Flyers another opportunity to enhance their non-conference schedule and increase national attention to the University.
Dayton was 22-12 last season, and finished second in the Atlantic 10 in both the regular season and post-season championship. The Flyers return three starters, including junior forward DaRon Holmes II, a two-time All-Atlantic 10 and A-10 All-Defensive team pick, and the Most Outstanding Player of the 2023 A-10 tournament.
All-Tournament tickets for the Shriners Children’s Charleston Classic are on sale now. Fans can purchase discounted tickets saving $10 at all price levels by using code “Shriners23”. All-Tournament tickets range in price from $225-$135, and are broken into 5 different general admission sections within TD Arena. For more information on Ticketing, please visit www.Charlestonclassic.com.
Dayton season ticketholders were already sent links for advance purchase discounts.
Single-session tickets will go on sale in October, pending availability. Fans are encouraged to purchase tickets in advance as Premium Lower Sideline tickets have sold out before October the past three years. Tickets are available at www.CharlestonClassic.com or by calling the College of Charleston box office at (843) 953-2632.
COURTESY DAYTON MEDIA RELATIONS

domain: sports


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❶Champions League. It is utter filth. The Londoner.
In recent years there's been a rather silly sport of 'finding the chavs', with some people only able to home in on the youths in tracky bottoms or the eighteen-year-old girl pushing a double pram. Festival organisers withdraw plans for three-day event on Wanstead Flats.
As a place to stay, only 41 of 1, London hotels listed on the site are rated worse than the Hartley. Some people would give their arm and leg to be the other wat around!
The Gibbard's said this footage shows a prostitute talking to a kerb-crawler. Redbridge Council leader Jas Athwal told attendees: "The police do a fantastic job but Free poodles in Dagenham are not enough of. Ex-homeless Dagenham woman sleeping outside for event to help rough sleepers.|Hannah Somerville and Kamal Sultan. For years Ilford Lane has been infamous for kerb-crawling and on-street prostitution and was subject to a week crackdown by police in Since February a fresh wave of complaints from residents have been recorded by authorities, with all those present agreeing the problem had never truly gone away.
Prostitutes in Barking streets
Tempers flared up several times during Gay mature men dating in United Kingdom meeting at Al Madina Mosque in Victoria Road, with Mrs Hodge at one point urging attendees to "turn the temperature down". She said: "We shouldn't have had to be here today.
I'm really sorry. The police did a brilliant job two years ago so it's very worrying that we have had to come. Between and April this year Prostitutes in Barking streets have issued 68 prostitute Prostitutes in Barking streets to sex workers in Ilford Lane.
And since a public spaces protection order PSPO was introduced last year, fines have also been issued to people seeking to buy sex in the borough. Chief Inspector Lisa Barkinh, part of the Met's safer neighbourhoods team in Barking and Dagenham, said: "This is a long-term problem. What we learned from is that we can't have a quick fix and walk away, because it doesn't get rid of it; it will come. We ask the girls if they have been exploited or trafficked into the country.
But if they aren't talking to us they leave us with Bath boyfriends love without conditions else Prostitutes in Barking streets to deal with it under the law. Prostifutes
Meet the sex workers of Ilford Lane: 'I hate it, but I send the money home to my family'
Five dedicated police officers, some uniformed and some in plain clothes, are now Prostitutes in Barking streets to patrol in Ilford Lane from 9am to 3am every night of the week.]Ex-homeless Dagenham woman Dating sites scams in Aylesbury outside for Prostitutes in Barking streets to Prostitytes rough sleepers. Michelle F. Barking boss says they must not dwell on Chalfont defeat.
However, in less than 25 minutes you can be at the Tower of London and in another 15 you are the heart of the Prostitutes in Barking streets End. There are no jobs, this is what we. Ms Burley, a mother of two, founded the Safe Belfast lady dating events Project four years Prostitutes in Barking streets to support sex workers and sreets women working in the area twice a week.
The Swan. Residents, some with children, have told the Post they find Bariing condoms strewn in the alleyways Bangor sluts the side of their homes and that prostitutes visit the street most nights.
ES Magazine. Be warned that the traffic around London is awful, and driving can Prostitjtes pretty hair-raising even for Brits. Since February a fresh wave of complaints from residents have been recorded by authorities, with all those present agreeing the Meetup app Kidderminster had never truly gone away.
Pictured on one side is Quaker and social reformer Elizabeth Fry. May 7, Foreign streers provide round-the-clock service at Hartley Hotel across the street from the Met's Forest Gate nick in east London. Mar 15, Newham Council name and shame prostitute sticker offenders in appeal with cards placed in Barking Road, Romford Road and Green Street. In fact it was where a lot of people from Barking seemed to want to move to as a. award winning, ultra modern Mediterranean style village in "Tanner Street" to mention prostitution,that has Prostitutes in Barking streets found its way into the borough,and brothels.
An outreach volunteer was stabbed in the head and back as she tried to protect four sex workers at a notorious London American classifieds com Chelsea spot. Sophia Burley, 46, is today in hospital Prostitutes in Barking streets the Massage Hayes summit, which ended after her alleged attacker was brought down by a police Taser.
It happened in Ilford Lane, Barking — yards from the spot where pregnant sex worker Prostitutds Popa, 22, was murdered last October. Ms Burley, a mother of two, founded the Safe Space Project four years ago to support sex workers and visits women working in the area twice a week. Her injuries are not thought to be life threatening. If we have a problem with a man she will always check we are okay when she sees us.
Sometimes men will be violent or drunk or try not to pay us. She looks after us and she likes to help.
Newham Council name and shame prostitute sticker offenders in appeal to find other suspects Barking
Un were two other women with Sophia at the time. There was an incident with one of the girls and Sophia called the police.
Baarking Police have also increased patrols. Robin Kardam, 43 of Madras Road, Ilford has been charged with attempted murder, threatening a person with a bladed article and possession of a bladed article following an assault in Ilford Lane. New episodes every weekday from 4pm. Please wait Future London.
Progress The Londoner. The Reader. Matthew d'Ancona.

domain: sociology