AstraZeneca’s Jason Snape, outlined his company’s approach to the environmental risk assessment of human medicinal products and what more needs to be in place to accomplish sustainable healthcare.
In October, Heath Europa attended CleanMed Europe 2018 at Radboud University Medical Center, Nijmegen, the Netherlands. This event, which explores sustainable healthcare, is designed to address the environmental risk and impact of the healthcare sector on a local, regional and global level.
Speaking at the conference, Professor Jason Snape, the senior principal environmental scientist within AstraZeneca who is responsible for the co-ordination of their Safety, Health and Environment (SHE) Research and Foresight programmes, delivered a presentation outlining some of the main points from his ten years of experience with the environmental risk assessment of human medicinal products.
He began his address by discussing some of the emerging pollutants and contaminants which are seen as being a cause for concern. While pharmaceuticals are often a part of such a discussion, Snape explained that his talk would focus specifically on the issue of pharmaceuticals in the environment, as well as some of the stakeholder concerns, and indeed areas such as where environmental issues sit within the drug discovery and development framework and the role of the environmental risk assessment approach. His speech also touched on the issue of antimicrobial resistance, which he described as “a key societal issue moving ahead”.
Snape continued by explaining that there is a lot of environmental monitoring data now being made available. However, this means that when the concentration of a particular drug is measured over time, the detection frequency is likely to increase (not least because an increasing amount of chemical analysis is being conducted), and while this increase may be seen as a cause for concern by regulators, or even an NGO or an academic, for Snape it is important to compare this concentration to agreed safe levels.
“You need to ask,” he said, “whether this provides any kind of reassurance. Is there an acceptable margin of safety there? Do we need any interventions for that compound? Is it an emerging pollutant?”
He then explained that pharmaceuticals can enter the environment in different ways, including through patient use, which, he argued, constitutes some 85-90% of the environmental burden. Drug production can also be a source – Snape said that this is responsible for around 2% of the pollution (which can result in hotspots of localised higher concentration), while the disposal of medicines in an irresponsible way can also result in environmental contamination.
Snape went on: “We design drugs so that most patients take them by oral therapy, and we therefore have to design in a certain level of stability as they have to get through the stomach and survive the microbes in the gut.” Here, ‘pseudo persistence’ means that the compound in question has some kind of functional persistence in order to work; it has got to get into the body and into the target. Different compounds have different half-lives and some, if they are truly persistent, can be non-degradable.
“If you have a compound in constant use, then it is always going to have an environmental burden, even if it has a short half-life,” Snape explained.
Any compound with a half-life of greater than 40 days is typically considered as being persistent. Once the use stops, and the shorter the half-life, the speed at which the environmental burden drops increases.
“Even if you have got compounds that are not persistent with very short half-lives, there is potential for them to be found in the environment,” he added. As such, AstraZeneca collates any literature that is published around any environmental concentrations of its drugs (Snape revealed that there are around 15,000 reports of his company’s drugs in the environment).
From this discussion, Snape concluded: “Everything will be found everywhere in the future because analytical chemistry is getting better… the number of pharmaceuticals they are going to find in the environment, be that in Africa, Europe, or North America, will increase and the number of pharmaceuticals will increase… so we have to get ready for that data coming though.”
However, he also explained that “presence doesn’t always equate to risk” and, as such, it is necessary to have a risk-based approach when thinking about contaminants of concern.
The ability to track a drug from the patient to see where drug targets are conserved helps to shape AstraZeneca’s environmental risk assessments. He explained to his audience that when attention is focused on protein-based targets, there are gaps in the publicly available data concerning the conservation of drug targets, making it difficult to properly establish which animal species may be at risk from a certain drug or compound.
He also highlighted the fact that some pharmaceuticals may be used in ways they were not originally designed for, or in unexpected locations, and so any subsequent environmental impacts would be completely unforeseen and, as such, pharmaceutical companies cannot, in fairness, be held responsible for such events.
Indeed, Snape said: “None of the environmental risk assessments that we do to launch a human medicinal product, or even a veterinary medicinal product, would [be able to] pick this up… and so we have to make sure we have got post-launch surveillance in place to capture some of those threats and bring in interventions when they are needed.”
Snape then returned to the issue of a lack of publicly available effects data for human medicinal products. “We only have public assessment reports that have environmental data in Europe if they are authorised through the centralised procedure,” he revealed, adding: “There are only a few companies that publish their data on their web pages; AstraZeneca was the first.” There are also knowledge gaps in terms of what the protected levels are, with significant data gaps existing for maybe 80% of active pharmaceutical ingredients (APIs) that were registered before 2006, Snape said.
He also mentioned what he termed “quite a dynamic external kind of scientific and regulatory landscape”, focusing on the European Commission’s strategic review and the European Medicine Agency’s (EMA) update of its environmental risk assessment guideline. Regarding the European Commission’s Pharmaceuticals in the Environment (PiE) strategy, Snape said that there are “a couple of options around strengthening expertise and the transparency of data, which are areas that we are quite supportive of.
“Any strengthening expertise and efforts towards making more data available, including the risk assessments in standardised format, is something that needs to happen, but it required taking ownership to make that happen.”
Indeed, there is currently no mandate for companies to work in this way, and yet it is clear that many of the environmentally successful industries have taken it upon themselves. Snape also suggested that, other than introducing such a mandate, this could also be achieved by “bringing environmental hazard and risk into the analysis”.
Snape then informed his audience about how the environmental impact of a medicine is taken into account during the drug development process. As a research-based company, AstraZeneca doesn’t sell generic or over-the-counter medicines. Rather, Snape explained, it is focused on either innovation or drug discovery and development – finding new targets and new medicines, looking at unmet needs, and then conducting pre-medical studies to look at safety and so on.
He explained: “We are looking in the region of €700m to get to the point of authorisation,” and it can take up to 20 years to get to market. “We have to get a return on investment to actually pay our shareholders but also to invest back into our client and the next line of innovation in terms of our medicines.”
Environmental risk assessments are not conducted until the clinical trials have reached Phase III, usually after around €600m has been invested in that drug. “We test the environmental risks after clinical safety has been developed,” Snape explained.
Nevertheless, this period has seen the pharmaceutical company supplying and producing the drug for clinical trials, and so work has been taking place in the lab to ensure that environmental hazards are kept to a minimum in terms of the process and the production.
The environmental risk assessment work that does go on to take place results in the identification of a safe concentration level that can be used as an environmental reference, which means that a limit of discharges on the drug production can be put into place.
“The final thing we do is ecopharmacovigilance,” Snape added. “This is done while the drug is being used by patients; we collect data from that product and can take it back and revise our discharge concentrations and environmental risk assessments. We also have other responsibilities, such as deciding what to do with unused medicines.”
The right thing to do
Regarding the ecopharmacovigilance conducted by AstraZeneca, Snape explained that they collate data from any material published around their products. They then compare this to the data they have themselves. If the levels differ to what they already have within their environmental risk assessment, then they conduct a quality review, asking whether the findings are reliable, robust and credible, and if they can be repeated.
“If this is the case,” Snape said, “then we review our environmental risk assessment assumptions and update our risk assessments and safe discharge levels. We try to keep our risk assessments alive, and while we are not required by rules or regulations to do [so], it is the right thing to do.”
Snape and his colleagues do not only collate the data, they also try to better understand what the data represents. In his presentation, Snape explained that there have been some 22,000 incidents where measurements of the environmental concentrations of AstraZeneca’s activities have been attempted, with 14,000 of those being above the limits of detection. “We want to know where they measure them and we compare them to the safe levels.”
“Ongoing vigilance is required to assess risk,” Snape concluded. “We think prospective environmental risk assessments could be supported by post-approval monitoring… there are big datasets for a lot of older and high-concentration compounds, but not for newer drugs, and we need a system in place to capture that as it comes through.”
Antibiotics and AMR
Turning his attention to antibiotics, Snape explained that these drugs, of course, enter the environment through human use, aquaculture, and drug production, but also animal husbandry. He also revealed that in addition to the antibiotic, resistant genes and bacteria are also entering the environment from a variety of sources, including biological waste treatment plants. “These resistant genes can be in environmentally relevant bacteria, but they can move into pathogenic bacteria… and get back into the patient.”
According to Snape, both the antibiotic and the co-selective agents can enter the environment and create a selective pressure or even an evolutionary pressure to develop resistant environmentally-relevant or pathogenic bacteria. “So when thinking about the risk assessment for antibiotics, we need to think about not only its environmental but also potentially its human health impact as well.”
There are thus broad protection goals and, for Snape, it is important to remember that the MIC data (the MIC is a database containing two-dimensional structures of synthesised compounds/antibiotics, IUPAC name, smiles notation and the MIC values/zone of inhibition against a particular organism, strain and culture conditions) and environmental data can differ, with the latter potentially being more sensitive – however, Snape emphasises, this does not mean that the environmental data is wrong.
Foe him, current risk analyses are inadequate; he explained that looking at the risk of an antibiotic does not take into account resistance, and, what is more, the current mode of action for a risk assessment only focuses on one species, and so this needs to be expanded in order to “have a wider range of bacteria in there covering a wider range of microbial ecosystem services. We also need to integrate environmental and human health within the risk assessments.”
Bringing his presentation to a close, Snape informed his audience that there is a need to ensure that patient access to medicines doesn’t adversely impact the natural environment, but that there is also a need “to be equally vigilant… that we don’t impact patient access to medicines; we need a debate that’s focused on environmental risk.
“The existing data… shows that most drugs don’t pose a risk to the natural environment, but there will always be some site-specific risks and site-specific interventions, and we need to get smarter in how to determine what they are and when to intervene.”
He also argued that not only the pharmaceutical industry but also all other actors need “to manage the risk of medicinal products across the whole of the life cycle.” He added: “Our industry needs to own and manage the risk associated with drug production; we might be able to do that on our own but might also need a pragmatic regulation or even responsible procurement… No reimbursement and no regulation exists, so at the moment it is down to responsible business in the absence of responsible procurement.”
Snape’s final message to the conference in Nijmegen was that unless industry and the regulators in Europe and beyond put more environmental data into the public domain, then many pharmaceutical products will appear to be a bigger risk than they actually are. “Some will, of course, pose a risk… but some will pose a risk at site-specific levels and until all of the environmental data is in the public domain, we can’t really have the risk-based debate that we need.”
This article will appear in issue 7 of Health Europa Quarterly, which will be published in November 2018.


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RESERVATION & INQUIRIES
For reservations and enquiries, please send an email, or fill in the contactform on this page.
Unfortunately the address is not recognised by google maps, the arrow in the maps above shows the correct location of the house.
Ulica Blaževića-Blaža 30, 52000 Skrad, Croatia
+31 6 44576462

domain: geography


The TowerRAID TR8M-B is an 8-bay storage enclosures for high capacity storage needs. With built-in ventilating protective screen front panel, both units utilize cable-less backplane-design to support up to eight hard drives. Hard drives are installed on easy access hard drive trays for simple insertion and removal. Hard drive cooling is provided by a large 4.7" cooling fan located on the back of the units. The TR8M-B is a compact RAID tower uses only two cables to connected eight SATA drives utilizing the latest SATA II port multiplier technology. Using the bundled two ports eSATA PCIe adapter, the user could easily access eight hard drives via JBOD mode, or two different sets of RAID 0, 1, 1+0 and 5 with spare. Units are available in black (TR8M-B) and silver (TR8M) finish.


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Zucchini Quiche with Tomato Topping
for one large or two small pies
sliced 1/4 inch thick
(or cheese of your choice)
cut into 1/4 inch lengthwise slices
Bring zucchini, onion, salt and water in saucepan to a boil.
Reduce heat and si mmer, uncovered for 8 minutes or until tender.
Drain in a colander.
In a large bowl combine milk, salt, pepper, oregano and eggs and beat with wire whip until smooth.
Add zucchini mix and cheese.
Stir gently to mix and pour into unbaked pie shell.
Bake in preheated 425 degree oven for 15 minutes.
Reduce heat to 350℉ (180℃) and bake 25 minutes.
TOPPING: Mix crackers with shredded cheese and or egano.
After quiche is baked, place tomato slices on top in a circle.
Sprinkle on cracker mix.
Return to oven until cheese melts.

domain: food


WHEELING, W.Va. — More than five years ago, Eric Kennedy flew almost halfway around the world to visit the grave of a World War II veteran he’d never met, but to whom he owes his very existence.
Now Kennedy, a biomedical engineering professor at Bucknell University in Pennsylvania, plans to use some of his sabbatical this year to uncover as much as he can about the life of 1st Lt. Robert Taylor – a Brooke County man who died when the plane he was piloting was shot down over Germany on Jan. 25, 1945.
He kept the plane stable long enough for his crew members to escape. Kennedy’s grandfather, Sgt. Edward Kennedy, was the last man off that plane before it crashed in a ball of flames with Taylor still aboard.
Although his grandfather never spoke of those events for years, Eric Kennedy learned of them through a brief account Edward Kennedy wrote during the 1980s. The significance of Taylor’s sacrifice has never left him, and has only grown with the birth of his children – Ellie, 4, and Calvin, 1.
“I would have never been on this earth had it not been for what Bobby Taylor did for my grandfather 70 years ago in 30 seconds of extreme duress. … My children wouldn’t be here if not for him, so there’s another generation that we’ll be sharing this story with,” Kennedy said.
Edward Kennedy died in January at the age of 93 – another loss among the dwindling fraternity of what’s become known as the “Greatest Generation.” Eric Kennedy said his grandfather – who always wanted to be a pilot but couldn’t pass the tests due to color-blindness – never forgot the man whose life was cut short so his might go on.
“Every day, he would get up and thank Bobby Taylor for giving him the chance to live his life,” Kennedy said.
In 2010, Eric Kennedy and his then-girlfriend, now wife, Carol flew to the Netherlands to visit Taylor’s grave, one among thousands marked by a vast field of white crosses. Feeling compelled to leave a memento behind, he pushed a pair of quarters into the soft ground near the marker – a West Virginia state quarter, for Taylor’s home state, and a Maryland quarter for his grandfather, a Baltimore native.
But beyond the location of his grave, Eric Kennedy knows little about the man who saved his grandfather’s life. He’s hoping his sabbatical from Bucknell will give him the time he needs to change that – and perhaps even make contact with a relative of Taylor’s – but he said his previous attempts to unearth information have led to dead ends.
“We’d love to make a connection just to see the other side of the story. … They might not even know the sacrifice he made and what that meant for all the men on his plane,” Kennedy said of any descendants of Taylor who might exist. “It might offer a chance for closure on both ends.”
Taylor was a member of the 558th Bomber Squadron, 387th Bomber Group and received the Distinguished Service Cross, Air Medal with 3 Oak Leaf Clusters and the Purple Heart during his service time.
Kennedy welcomes anyone with information about Taylor to contact him via email at [email protected]


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À propos de l’auteur

domain: economics


Bean to Bar Chocolate Equipment
BEAN TO BAR CHOCOLATE
The process of truly making chocolate, from the unroasted bean through to the finished bar. A craft product in its purest form, driven by passion and creativity, supporting impoverished communities globally.
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We provide equipment solutions for bean to bar makers for every stage of production. Please get in touch with us to discuss your exact requirements so we can advise you on the most suited piece of equipment to achieve your product outcome.
Providing a fast, simple and very efficient separation of unwanted matter such as stones from the unroasted cocoa bean
Purpose built to specifically support roasting of cocoa beans, and including hazelnuts, almonds, macadamia nuts, pistachio and other beans
Single & twin sieve, cracking and removing the fibrous husk, leaving only the nib at highest yield and purity
Applies pressure to the cocoa mass to extract the cocoa butter. The remaining mass is ground into cocoa powder for use in drinking chocolate, compound chocolate & baking products
Low speed circulation ball bearings grind chocolate mass with other ingredients to make liquid chocolate (18-20 microns). Can also be used to grind nuts such as hazelnuts, pistachio, peanuts etc. for spread creams and pastes
Purpose built for bean to bar and two ingredient chocolate. Mixer, high sheer emulsifier with speed control, hot air injector, acidity and humidity extractor, recycling pump to aid in oxygenation and touch screen PLC control
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Jasper + Myrtle Chocolates


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I dont recall where I saw it, but IIRC, the use of peat filtration and/or Blackwater Extract affects the standard calculation of CO2 concentration, which can normally be obtained if pH and KH are known. I am converting a 29 gal to a blackwater biotope, and am going to use Kent Black Water Expert to achieve the proper conditions.
Is there an easy way to calculate CO2 concentrations when the additive is used, or do I need a CO2 test kit?
This article talks about phosphate buffers throwing off the CO2 calculations, but does not say what to do if there are phosphate buffers in the water (for example from the water supply).
Also, it says nothing about tannic and humic acids, which are used in blackwater set-ups. I assume that any non-carbonate based buffer would throw off the pH-KH-CO2 relationship, but I have not been able to find anything for sure about this.
Tannic and humic acids will throw off the co2 chart as will phosphates including those in your water supply. The only way to use those products and know your co2 level is to get a co2 test kit such as the one lamotte sells.
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domain: chemistry


text:
This weekend looks like it’s going to be a rainy one, but that doesn’t mean you have to stay indoors. Check out the Georgetown Loop Railroad! They offer train rides, mine tours and dinner rides.
The Loop: You may want to pay a little extra for the fully enclosed car, but this 3.1 miles loop will take you over 4 bridges, up 640 feet and around 2 corkscrew loops. This ride from Georgetown to Silver Plume provides stunning views of the Clear Creek Valley. For more about this exciting ride click here.
Mine Tour: Why not add a little more excitement to your day by adding a mine tour to the itinerary. You can check out the Lebanon Silver Mine or the Lebanon Extension Mine. Both options are only accessible by train and will take you back in time to explore some rich history. For more details and tour lengths click here.
Dinner Rides: Choose between the wine and cheese train or the beer and brat train. All rides take place in a parlor car and will take you on an hour and a half journey through the Georgetown-Silver Plume National Historic District. Ride times are more limited, click here for more information.
Any of these options would be a great way to see some stunning views, learn about Colorado’s mining history and create some great memories. For more information and to book a ride contact either the Grand Time Lodge or Grand Lodge on Peak 7 Activities Department.

domain: hobby


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This 5 valve AC mains table model was manufactured in 1954 by Kolster-Brandes of Footscray Kent. The cabinet surface is covered in a dark two-tone walnut veneer. This radio featured 3 reception wavebands, medium, long and shortwave selected by means of a rotary switch. An internal ferrite rod aerial is fitted for reception of local stations. Extension sockets at the rear were provided for gram pick-up, speaker, aerial and earth connections. This receiver has undergone a complete restoration in our museum workshop and is now in full working order.
The retail-selling price was £15.10s.0d plus purchase tax.


The devout Muslim father of a 16-year-old girl, whose friends say was killed for not wearing a hijab, has been charged with second-degree murder and denied bail.
Aqsa Parvez died on Monday night in hospital after being attacked in her home in a suburb of Toronto.
Police have not commented on any motive in the case.
But the girl's friends said Parvez frequently clashed with her estranged family over her reluctance to wear a traditional Islamic headscarf, or hijab.
"She would tell us how her dad would always yell at her and how he wanted her to be someone else," her friend Natalie Rance, 14, told the daily Toronto Star.
"Her dad wanted her to be a person who followed the religion. But she wanted to follow her own rules, wear her own clothes. But her dad wouldn't let her do that."
Police said in a statement they received an emergency call at 7.55 am local time Monday from "a man who indicated that he had just killed his daughter".
In fact, the girl clung to life for hours after she was rushed to hospital, said officials. An autopsy determined that the cause of death was "neck compression".
Her father, cab driver Muhammad Parvez, 57, was arrested at the scene.
The victim's 26 year-old brother Waqas was also charged with obstructing police in the investigation.
According to her friends, Aqsa had worn the hijab at school last year, but rebelled in recent months.
They said she would leave home wearing a hijab and loose-fitting clothes, but would take off her head scarf and change into tighter garments at school, then change back before going home at the end of the day.
Two weeks ago, she left home for the second time in three months, and had been staying with a friend. According to reports, she returned to her parents' home Monday only to collect her belongings.
Wendy Horton, executive director of a Toronto shelter where Parvez found refuge during a previous altercation with her father, told the Star the root cause of their strife is not uncommon.
Immigrant parents want their children to remain faithful to traditional ways but find themselves at odds with kids growing up in Western society. "It creates a lot of tension," she told the paper.
The Parvez family had emigrated from Pakistan, she noted.
Across Canada, the killing has taken on larger proportions, with many using it to more broadly indict fundamentalist Islam, and one internet blogger going as far as suggesting a boycott of all taxicabs driven by Muslims.
But a spokesman for the Canadian Council on American-Islamic Relations (CAIR-CAN) said he is dubious of opinions the girl's death resulted from a clash of cultures.
"Teen rebellion is something that exists in all households in Canada and is not unique to any culture or background," CAIR-CAN's Sameer Zuberi told AFP. "Domestic violence is also not unique to Muslims."
"The strangulation death of Ms. Parvez was the result of domestic violence, a problem that cuts across Canadian society and is blind to color or creed," echoed Shahina Siddiqui, president of the Islamic Social Services Association.
The two groups and 18 other Muslim groups in an open letter to prosecutors asked for the strongest possible prosecution of her killer, and "zero tolerance for violence of any kind against women or girls".
Dressed in orange prison garb, Muhammad Parvez appeared unemotional during his brief court appearance, muttering his responses to the judge. His next court date is scheduled for January 29.
Outside the courtroom, one of the victim's seven siblings, Sean Parvez, told reporters, "We don't know" what led to the assault.


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London: Scotland Yard has passed a file to UK prosecutors to review whether the two Australian DJs had committed any offences by making hoax call that led to the apparent suicide of Indian nurse Jacintha Saldnha.
Scotland Yard has been investigating the circumstances that led up to the apparent suicide of Jacintha Saldanha, a nurse at the King Edward VII Hospital, after she answered a phone call from two DJs pretending to be members of the Royal Family.
A spokesman of Scotland Yard today said Detectives have passed a file to the Crown Prosecution Service (CPS) to review whether "any potential offences may have been committed by making the hoax call".
It has not been disclosed what possible offences Scotland Yard have been pursuing, but detectives are thought to have examined whether DJs from 2Day FM radio station in Sydney, Mel Greig and Michael Christian, breached the Data Protection Act.
The legislation makes it an offence to "knowingly or recklessly... Obtain or disclose personal data or the information contained in personal data".
It is unclear whether the DJs could face extradition from Australia to Britain if the CPS decides there is a reasonable chance of securing a conviction in the courts.
The Data Protection Act offence is punishable by a fine rather than imprisonment - up to a 5,000 pounds fine in the magistrates` court or an unlimited fine in the Crown court.
The Scotland Yard spokesman said: "Following the death of Jacintha Saldanha, officers have liaised with the Crown Prosecution Service as to whether any criminal offences had been committed in relation to the hoax call made to King Edward VII Hospital in the early hours of Tuesday December 4."
"On Wednesday December 19, officers submitted a file to the Crown Prosecution Service for them to consider whether any potential offences may have been committed by making the hoax call."
Saldanha, 46, a mother of two, was found dead in staff accommodation at the hospital where the Duchess, 30, had been treated for acute morning sickness.
The nurse had answered the telephone at the hospital in Marylebone, central London, and the two presenters convinced her they were the Queen and the Prince of Wales.
Saldanha transferred the call to another nurse who unwittingly gave the DJs an update on the Duchess’s condition.
Three days later the nurse was found hanging.
She had left three suicide notes, her inquest revealed.
It has been reported that she wrote in one of three suicide notes that she expressed "deep anger" against the DJs and held them responsible for her death.
Saldanha`s funeral took place on Monday in Shirva, near Mangalore in Karnataka.

domain: news


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As I have posted about before, when it comes to photographing the shinkansen, I prefer not to take pictures at stations. There are times – particularly when you are travelling on a stopping-service – when it is convenient to do so, getting a shot of a passing train (pictures of stopped trains tend to be dull). However, there is one station that can be particularly interesting to get photos at – not so much for the station itself, but due to what’s next to it. That station is Hakata-Minami.
Hakata-Minami (“Hakata-South”, 博多南) sits next to the Hakata Depot. The station itself opened in 1975 and the station gained in usage as the city of Fukuoka continued to grow and spread. While the opening of the section of Kyushu Shinkansen between Hakata and Shin-Yatsushiro in 2011 now means that some of the line to the station is shared, the services to Hakata-Minami are operated by JR West, not JR Kyushu.
I have been to Hakata-Minami a couple times. At least once as I had some time to spare, so, taking advantage of my JR Pass, decided to jump on a train that was going that way and taking advantage of the seat to sit down and eat, before returning to Hakata – before doing this, make sure that you will make any connection at Hakata as there aren’t that many services. There is only one platform at Hakata-Minami (the only shinkansen station with just one platform), so there is no danger of missing your train there and often you will return on the same train that you arrived on.
Here are some shots taken at Hakata-Minami (all taken in 2003). As you can see, it’s the view of the trains in the depot which are perhaps more interesting (although most of the time, the trains are stopped, at least the variety in rolling stock makes it interesting).
The first two were in my book Shinkansen: From Bullet Train to Symbol of Modern Japan…
For more information about my research on the shinkansen, click here, and for more information about the photographs I use in my research, click here. Click here to get more information about my novel Hijacking Japan which is partly set on a shinkansen.


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sala boutique, the collection of intimate hotels in Thailand, is inviting Thai residents to break free from their daily routine and discover an inspiring staycation, with attractive rates at four stylish properties across the kingdom.
Under the new Weekday Specials promotion, Thai nationals and international expats will benefit from discounts of up to 35% on the best available rates for a wide variety of rooms and suites, as well as complimentary drinks at sala boutique’s collection of stunning rooftop bars and lounges.
With hotels in the historical hearts of Bangkok and Chiang Mai, the charming heritage city of Ayutthaya and the verdant hills of Khao Yai, this upscale collection of boutique retreats provides the perfect setting to kickstart the new decade.
Valid from now until the end of March 2020, the Weekday Specials offer rewards Thai residents who book direct for stays on Sundays to Thursdays in the first three months of the year. Guests taking a weekday stay in January 2020 will enjoy a generous 20% off their nightly room rate, while that booking stays in February and March 2020 will receive a fantastic 35% discount. Whenever they choose to stay, all guests will receive a complimentary drink at their hotel’s rooftop bar.
At sala rattanakosin, guests can sit back and soak up panoramic views of Bangkok’s Chao Phraya, the “River of Kings”, and Wat Arun, the golden “Temple of Dawn” on the opposite bank. Nestled in the oldest part of the Thai capital, close to the Grand Palace, this riverside hotel is ideal for cultural staycations. Weekday Specials rates start from THB 2,574++ per room per night.
Guests at sala lanna in Chiang Mai can discover the many attractions of this ancient walled city, including its temples and markets. This elegant hotel is set directly on the banks of the Ping River, and the rooftop bar promises 360-degree views of the city skyline and mountains beyond. Book direct and discover rates starting from THB 1,872+++ per room per night!
Located just 60km from Bangkok, the enchanting heritage city of Ayutthaya is wonderful for guests seeking a break from the city. sala ayutthaya, the chic boutique hotel, allows visitors to unwind and soak up spectacular views of the Chao Phraya River and Wat Phutthaisawan. Experience a Weekday Getaway in Thailand’s ancient capital from just THB 2,821++ per room per night.
Finally at sala khaoyai, guests can chill out in seclusion and serenity, while savouring breath-taking views stretching out across the rolling green hills. Seven spacious rooms and pool villas are available, and nature lovers can explore UNESCO-listed Khao Yai National Park, which is just a short distance away. Promotional rates start from only THB 2,990+++ per room per night.
Whether you’re seeking an exhilarating urban break or a more relaxing retreat away from the hustle and bustle of the city, sala boutique is the perfect choice for your start-of-year staycation. All Weekday Special rates are also valid for online bookings made directly on www.salahospitality.com.

domain: travel


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Hire Food Van in Luton
Browse Food Vans & Trailers
Recent review: Fabulous fish & chips, freshly cooked. Our party guests thought it a great treat. Service was excellent and very easy to organise. We will definitely book the Frying Squad for a party again
Recent review: Fantastic service, we had communication on the run to the event to confirm timings and menu choices. On the day of the event the pizzas surpassed our expectations!! They were fantastic and all the guests loved them and requested Fillipo’s contact details. Will definitely use this service for futur
Recent review: Alberto was a great addition to our party. The pizza dough was made fresh and the pizzas were delicious. All our guests were so impressed with the quality and speed of serving.
Recent review: These guys are fantastic. Everything that they did was above expectation from helping with menu suggestions to location planning on the night. The pizza and garlic bread themselves were absolutely fantastic, all my guests have commented on how good they were! Monika and Bart were both very friend
About: Here at Jacks Smoke Shack we offer a great range of packages to cater for your event which gives a great alternative to more traditional buffets or hog roasts and is sure to leave your guests with something to talk about and some great memories for a long time to come. Were also able to offer a m
About: Indian Street 147 was started by two cousins who are passionate about true Indian food, we wanted to provide our customers with real Indian snacks that are eaten on the streets of India and Indian homes everywhere. Our delicious food is all homemade using fresh ingredients and aromatic spices sour
About: A bespoke catering service.
About: Quality mobile ice cream business based in Bedfordshire UK. Available for hire for your event. Competitive rates for weddings, parties, proms and corporate. Large selection of traditional Mr Whippy style ice creams and desserts. Ice Cold Slush also available. The latest Euro 6 compliant M
Recent review: We booked Wood Fired Wonders for a corporate fun day. The pizza was amazing and they offered a great range of sides and salads to go with it. You will struggle to find a more authentic pizza. The guys were very easy to deal with and very hard working. The pizza came out fresh and hot exactly when we
About: At Ruff Wood Pizza we not only care about serving fantastic fresh Wood fired pizza but also having a mobile set up that will really help your event " Stand out from the Crowd". Whether you need a unique catering option for a Wedding, Party or Corporate event then look no further as we have the perf
About: I am Ozi, a trained chef based in Amersham with a Food Truck specialised in Levantine Street Food called Ozi Lala. The Levant is the very east of the Mediterranean coast consists of southern Turkey, Cyprus, Lebanon, Isreal and Jordan, where strong food cultures and rich traditions have created a di
About: We are a small family run food business serving crêpes and other delicious deserts. We are available for weddings, festivals, events and street food.
Recent review: Bruno catered for my charity event last year for over 300 people and the level of service was very professional and they also donated a sizeable amount to our charity. I was very impressed with the service and would recommend them.
About: Ciao!, We're a family run Italian Neapolitan Pizzeria company based in Milton Keynes. We have a lovely new van with contemporary looks, bright turquoise with a contrasting orange tiled Italian oven, aesthetics aside on the plus side the oven is dual fuel gas/wood - therefore we have the capability
About: My custom-built Pizza pod is available for your next extra special event. I make every pizza to order using only fresh ingredients sourced locally and from Italy. I cover the whole of the South East and London with further locations always considered. If you have an event coming up from weddings to
Recent review: Lauren could not have been more helpful in catering for our wedding party. Especially in dealing with allergies. Our guests were raving about it!
About: Covering the whole of the UK, including the Home Counties and London, catering services don’t get much better than Grilliant! Our buffet, spit roast and BBQ service allows you to eat, relax and enjoy your event with friends, family or business associates while we take care of everything
About: The company grew quickly diversifying into all areas of mobile event catering and now provides its services to a number of London borough councils including Westminster and Kensington & Chelsea.
About: The Healthy Jamaican Kitchen is a very popular authentic home cooked Jamaican food truck, that can be hiredto attend special events, food festivals and street food events.
About: Michelin Trained Chefs serving modern Street food and Craft Beer; items like Ox Cheek sliders on charcoal buns with Green Chilli Slaw and steamed Bao Buns with Braised lamb shoulder and green harissa will be served along with some amazing Craft Beers from Brewers such as Beaver town, And Union and C


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God forbid it ever snows during your spring break.
This past March, my friends and I took a road trip to Arizona expecting the sun, the warmth, and the good ol’ Grand Canyon. Unfortunately, on one of the days, we were transported to the set of Narnia. I tried to escape the freezing temperatures of Chicago where I live 66 percent of the year and where the temperature is negative 88 percent of the time, but alas, the fates had other plans.
I made Keishel and Peter wake up early to go watch the sunrise* on our last day in Grand Canyon. We had missed the sunrise the first two days we were there (because we don’t like waking up early) and the sunsets too (because the weather decided it was PMSing and rained like a b*tch throughout). The clouds were overcast when we stepped outside of our cabin, but we were going to push forth! (I insisted.)
*I’m a great friend, I know.
The weather didn’t get any better.
It started to snow. The clouds turned gray and the trees turned white. We drove to this one supposedly really scenic lookout—Yavapai Point—but when we stepped onto the viewpoint, it was basically a canvas of fog. We couldn’t see anything (was it really scenic? I’ll never know).
Peter, who can never stay put, started to wander and see what else was around the area while I took the opportunity to take some photos. Keishel was down to do the same (bless you, K). After that, we just drove around and tried to find some people to talk to–there weren’t many–then grabbed some food and hot coffee (mmmm).
I admit, seeing snow in Grand Canyon was kind of mesmerizing.
I mean, when you Google photos of the Grand Canyon, when do the results ever show the park blanketed with snow? I think I was kind of lucky. (A little annoyed we missed the sunrise, but whatever.)
So, if it ever snows during your spring break, here are some things you can do:
1. Take photos. Pretend like you’re the White Witch of Narnia and own the damn land. The photos will make for good (or bad) #memories, but killer Instas for sure (why else would you go anywhere for spring break?). I, at least, was prepared clothing-wise, but if all you have is a bikini and bathing suit… I don’t condone it, but good Insta material for sure.
2. Get a hot drink. Chances are your insides will be cold because you will be ill-prepared for winter weather. A hot chocolate/coffee/tea/[insert beverage of choice] will do you wonders.
3. Stay inside. It’s OK if you fear the cold. (I will push anyone who tries to make a joke about Frozen down the canyon).
What would you do if it snowed during spring break?


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Second week of Monster March! I should be at half of the total work, but I think that I have done less than it. Well let's see the job. This monster is the last of the Nurgle Wave that touches my table in december. You can easily see all the Nurgle things searching on this blog.
I have a pair of new project to do, but I am going out the path. The Glottkin now.
First of all, a recap of all the steps:
- third week: details and finish;
- fourth week: everything it is missing.
I think that the fourth week is going to be dedicated to the two smaller brother: this model is very big damn, and the two small brother are the rotten cherry on the cake of.. better don't know of what is made a Nurgle cake!
First, I painted a bit the Bubbles. I have seen some pics of bubbles etc. on the Internet (do not do some search.. what you have seen could not be unseen...) and I've found some nice bubbles that where white-cream (full of pus) and with the skin near red. I decided to do the biggest part of them in this way.
The model is full of bubble, maybe I'll search again some black plague bubbles to add more variety.
Here a pic that I really like, because there is most of my way of painting Nurgle daemons and beasts.
You can see textured paint, bubbles, different and caual washes, puddles of colours, and a "dotty" painting on the arm, given by sponge. I'm very proud of it! Ah the pics is less green (also the next) than reality: I'll never be able to understand the magic in the pics, however the real tone is the one in the upper pic (and in the ones with the full body).
And here the promised butt pic, with its horns that make the sitting uncomfortable but I think it is the last of your problem when you are one of the choosen by Nurgle.
Here we are quite ahead: I have painted fangs, the mouthy arm, added a bit of gore on the belly mouth (this guys is full of mouths) and glossed some horns. also I have added a bit of gore. This is how I am approaching this guys: I am not painting all the bubbles, than all the horns, and so on, but a bit of horns, a bit of bubbles, a bit of gore etc. and then I restart the cycle. In this way I can have a better idea of what it is going to be, and I do not be bored of the hundreds of horns or tons of bubbles. It is a bit time consuming, bit for this guy I have more fun in this way.
Here all the horns are almost finished, I painted the tongue of the arm: the black and white primer helps a lot, I have only added some watered down reds, and the primers did all the jobs. I think that I'll add some wash to it, then it will be a web of saliva and blooooooood!
There are also a good number of strange bubbles that I tried to make like eyes like GW: the result is not too much bad, but I have to improve. A said, they are not all done, I'll return on them soon. I've painted the dress in red to recall the red of the naked muscles on the back (I have interpreded those parts like muscles) and logically it is not finished. I have no idea how to paint the symbol of Nurgle. I think I'm going to paint it simply in red.
The W&N inks are amazing for skulls and glossy finish!
This model is Huge, and there is a lot of things to do.
Next week base, splashed colours, metals, other details and maybe I'll start one of the smaller bros. Stay tuned!

domain: artistic


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New York League Of Puerto Rican Women, Inc.
The New York League of Puerto Rican Women, Inc. is a non-partisan, not-for-profit 501(c)6 organization whose mission is the advancement of Puerto Rican / Hispanic women through higher education. The League is one of the few organizations in the nation that assists Puerto Rican / Hispanic women by providing them with the financial support necessary to obtain their college degree. The proceeds of our events go toward the funding of the League’s Scholarship Program. The League commenced its mission in December of 2008 and had its first Scholarship Gala Dinner Dance in August of 2009. As of September 1, 2022, the League has presented 129 scholarships, totaling $124,000, to undergraduate Puerto Rican / Hispanic women selected for their academic excellence and service to the community.
Chief Financial Officer
Address3154 Anthem Way
Vero Beach, FL 32966-8983
Listed Under CategoriesNonprofit Organizations

domain: sociology


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Price Beat Guarantee*
Find a lower comparable hotel price online and we'll beat it by 10%. Find out more.
When you stay at U Magic Palace Hotel in Eilat, you'll be near the beach, within a 10-minute drive of Dolphin Reef and Coral Beach Nature Reserve. This family-friendly hotel is 11 mi (17.7 km) from Port of Aqaba and 0.4 mi (0.7 km) from Ice Mall.Rooms
Make yourself at home in one of the 322 guestrooms featuring minibars and LCD televisions. Complimentary wireless Internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have bathtubs or showers and hair dryers. Conveniences include safes and desks, and housekeeping is provided daily.Amenities
Enjoy recreational amenities such as an outdoor pool and a 24-hour fitness center. Additional amenities at this hotel include complimentary wireless Internet access, concierge services, and babysitting/childcare (surcharge).Dining
Enjoy regional cuisine at Emerald Dining Room, one of the hotel's 2 restaurants, or stay in and take advantage of the 24-hour room service. Snacks are also available at the coffee shop/café. Relax with a refreshing drink from the poolside bar or one of the 2 bars/lounges. Breakfast is available for a fee.Business, Other Amenities
Featured amenities include dry cleaning/laundry services, a 24-hour front desk, and multilingual staff. Free self parking is available onsite.Attractions
Distances are displayed to the nearest 0.1 mile and kilometer.
Eilat Marina - 0.3 km / 0.2 mi
Ice Mall - 0.7 km / 0.4 mi
Ice Space - 0.7 km / 0.5 mi
Spiral Park - 0.8 km / 0.5 mi
Harbor Bridge - 0.8 km / 0.5 mi
Eilat Museum and Art Gallery - 0.9 km / 0.6 mi
Green Beach - 0.9 km / 0.6 mi
Mall Hayam - 1 km / 0.6 mi
Mifrats Beach - 1 km / 0.6 mi
Papaya Beach - 1.1 km / 0.7 mi
Dekel Beach - 2.1 km / 1.3 mi
Botanical Garden Of Eilat - 3 km / 1.9 mi
Port of Eilat - 3.2 km / 2 mi
Dolphin Reef - 4.3 km / 2.6 mi
Coral Beach Nature Reserve - 6.7 km / 4.1 mi
The nearest airports are:
Ovda (VDA) - 60.8 km / 37.8 mi
Aqaba (AQJ-King Hussein Intl.) - 12.4 km / 7.7 mi
Eilat (ETM-Ramon Intl.) - 20.2 km / 12.6 mi
Taba (TCP-Taba Intl.) - 48.8 km / 30.3 mi
The preferred airport for U Magic Palace Hotel is Ovda (VDA).
Extra-person charges may apply and vary depending on property policy.
Government-issued photo identification and a credit card, debit card, or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Please note that cultural norms and guest policies may differ by country and by property. The policies listed are provided by the property.
For more details, please contact the property using the information on the booking confirmation. Check-in hours start at 9 PM on Saturdays and Jewish holidays.
Please note, there is important information about this property to know before you arrive.
- The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
- No pets and no service animals are allowed at this property.
The following fees and deposits are charged by the property at time of service, check-in, or check-out.
- Breakfast fee: ILS 90 per person (approximately)
- Crib (infant bed) fee: ILS 30.0 per night
- Rollaway bed fee: ILS 0.01 per day
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
- -Accessible bathroom
- -In-room accessibility
- -Multilingual staff
- -Shopping on site
- -Roll-in shower
- -Breakfast available (surcharge)
- -Coffee shop or café
- -Poolside bar
- -Safe-deposit box at front desk
- -24-hour front desk
- -Concierge services
- -Smoke-free property
- -Gift shops or newsstand
- -Hair salon
- -Free WiFi
- -Outdoor pool
- -Children's pool
- -Spa treatment room(s)
- -24-hour fitness facilities
- -Barbecue grill(s)
- -Laundry facilities
- -Dry cleaning/laundry service
- -Free self parking
- -One meeting room
- -Newspapers in lobby (surcharge)
- -Tours/ticket assistance
- -Spa services on site
- -Babysitting or childcare (surcharge)
- -Arcade/game room
- -Children's club (free)
- -Number of bars/lounges - 2
- -Number of restaurants - 2
- -Luggage storage
- -Rooftop terrace
- -Supervised childcare/activities (surcharge)
- -Wheelchair accessible path of travel
- -Wheelchair accessible parking
- -Braille or raised signage


According to the latest research conducted, the demand for Acrylonitrile is anticipated to grow with a compelling growth rate of about 3.5% to 5.0% in between the coming assessment period of 2021-2031.
Ammonia, propylene and propane are used as a raw material for the production of acrylonitrile. It is used in many industries for the production of variety of polymers and thermoplastics. Some major uses include acrylic fibres, nitrile rubber, ABS and others.
The increasing demand for acrylic fibres manufactured from acrylonitrile is expected to drive the market over the forecast period. It is also one of the primary raw materials in the production of plastics and composites, which is further anticipated to propel its global demand.
Download FREE Sample Copy of Report: https://www.futuremarketinsights.com/reports/sample/rep-gb-13906
What is Driving Demand for Acrylonitrile
Major factors driving the market are the growing demand from construction industry and automotive industry.
The extensive usage of acrylonitrile in the building sector for headliners, interior grills, centre consoles, and other applications is one of the primary drivers driving the market’s growth.
The construction industry’s rapid rise has fueled the market demand.
It is also used in the automotive industry to make critical components such as seatbelts, instrument panels, dashboards, and other such items.
The increased usage of nitrile rubber and other plastics in automotive manufacturing aids in weight reduction and efficiency gains. These are the primary drivers of market growth over the forecast period.
Growth of Textile and Automotive Industry Increases the Demand of Acrylonitrile
The growing textile and apparel industry in emerging economies of the Asia-Pacific region, due to rising urbanization and increasing affordability is anticipated to drive the market for acrylic fibre over the forecast period.
Acrylic fibres are used extensively in the textile and packaging industries. They possess high resistance to laundry bleach, ultraviolet degradation, and microbiological attack, along with an aesthetic appeal.
These fibres are also light in weight and have a comfort feel the softness, making them a great choice for clothing.
People’s lifestyles have changed dramatically as a result of rapid urbanisation. As cities grow, so does the demand for transportation.
To meet this rising demand, many vehicle manufacturers have developed industrial operations in various regions of the world.
As the need for car parts, accessories, and raw materials has grown, so has the demand for spare parts, accessories, and raw materials.
Acrylonitrile is a chemical substance that is used to make bumpers, dashboards, seats, lighting equipment, centre consoles, and headliners for automobiles.
In recent years, such broad applications have significantly expanded the scope of this substance in the market.
Request Brochure of Report: https://www.futuremarketinsights.com/reports/brochure/rep-gb-13906
APAC Market Outlook
Due to the rapid expansion of the automotive and construction industries in the region’s growing countries, the Asia-Pacific region accounts for a large portion of the worldwide acrylonitrile market.
In China and India, high demand for electrical and electronics, household appliances, gadgets, and autos is boosting market growth.
The top importers in the region are China, India, and Korea. China is also a major manufacturer of the chemical.
Moreover, the demand for acrylic fibres in the garment and home furnishings industries is increasing.
Increased demand for acrylonitrile in China has come from an expansion in the manufacturing of electrical and electronic goods in the country over the years.
China is the world’s largest market for electric vehicles. The market is being driven by the country’s expanding demand for electric automobiles.
Europe and North America Demand Outlook
The market in North America is also expected to grow rapidly due to an increase in demand for lightweight materials in the transportation sector.
The acrylonitrile market in Europe is also expected to grow steadily due to its high demand in the region’s large automotive industry, particularly in the production of heavy-duty vehicles.
The expanding automotive industry in the European region, which is focusing to produce much more light-weight and energy-efficient vehicles in order to reduce carbon dioxide emissions, has increased market demand.
Who are the Key Manufacturers and Suppliers
Some of the leading manufacturers and suppliers include
- Formosa Plastics Corp.
- Mitsubishi Chemical Corporation
- Sumitomo Chemical Company Ltd
- Sinopec Group
- Asahi Kasei
- Ascend Performance Material
- Taekwang Industrial Co. Ltd
- ShanghaiSECCOPetrochemical Company Limited and many others.
Significant growth of the acrylonitrile production in automotive, building construction areas and textile industry in countries such as China and India is driving the market in the Asian-pacific region.
Several countries are investing in China and India as they are the fastest-growing market in the future and the center hub of the automobile and textile industries; thus, several companies start investing in these industries.
Get Customization in the Report, Enquire Now @ https://www.futuremarketinsights.com/customization-available/rep-gb-13906
By End- Use:
- Electrical and Electronics
- Styrene (ABS)
- Acrylic Fibre
- Nitrile Butadiene Rubber


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Helping you achieve financial freedom
Our team of financial planning experts at Ultimum Financial can help you to implement strategies so you can achieve the best possible outcomes for your financial future. We do this by listening and obtaining a comprehensive understanding of your unique personal circumstances, needs and objectives and consider how we can help you to achieve financial freedom.
Whether you are looking to build, protect or maintain your wealth for retirement or future generations, we will assist you to set up and maintain a financial strategy that will help you achieve your objectives in a simple, practical and tax effective way.
We strive to provide our clients with trustworthy and expert advice to assist you to navigate through simple or complex financial situation of wealth creation, superannuation, debt management, personal insurance, estate planning and we also offer a holistic advice solution to meet all your ongoing financial goals and aspirations. Our financial planners can provide personalised and tailored financial advice to individuals, couples, families, or businesses to successfully achieve desired results.
You will be able to take comfort in knowing that your financial world is on the right path and is being taken care of by financial experts that want the best possible outcomes for your future. We endeavour to build and cultivate strong relationships with each of our clients to ensure they feel comfortable, secure and confident in their financial journey with us.
At Ultimum Financial we are not incentivised or aligned with by any financial institutions or product providers. Our financial planning experts only provide personalised and tailored financial advice and solutions that we believe are truly in the best interests of our client’s future.
How Can We Help?
Your personal financial planning experts at Ultimum Financial are here to ensure that you have all the knowledge, ability and information you need to make smart financial choices for your short, medium and long term goals.
Our highly qualified and experience team of professionals will provide you with financial advice, strategies and guidance to help you achieve your financial aspirations and give you a sense of security for the future.
We can help you achieve financial freedom by
– Listening and obtaining a comprehensive understanding of your unique personal circumstance, needs and objectives.
– Helping you to create and determine your financial goals and aspirations for the short, medium and long term.
– Discussing your financial circumstances whether they be simple or complex and determining the best financial risk profile and investment strategy to help you achieve your goals.
– Implement strategies and recommendations to put you on the right path to attaining your dream future.
– Ensure your superannuation and retirement plans are achievable and what recommendations can be made to grow your wealth.
– Work with you to provide strategies to manage and reduce your outstanding debts.
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We are always here for you and believe that your dedicated financial adviser at Ultimum Financial will be your financial partner throughout life. We are here to provide you with financial decision support, expert knowledge and guidance to meet your financial aspirations.
With our experts help you can take comfort knowing that you are on the right path to achieving financial freedom.
If your unsure what services would be applicable to your life stage, check out the video below or click on the services tab to get started!

domain: finance


text: Charlotte Maddox points out baby turtles swimming around a tank to Olivia Roberts and her son, Parker Maddox while on a visit to the Ritz Carlton's Nature's Wonders exhibit on Thursday, Aug. 7, 2008. As a part of their guest services, the Ritz Carlton offers children staying in the hotel a chance to learn about Florida's ecosystem by attending a day-camp inside the Nature's Wonders center. The kids spend the day interacting with various marine animals and learning about what species live near the hotel. At the end of the day, the Nature's Wonders center opens its doors for an open house, during which many children bring their parents. "It's interesting to see the kids come back with their parents in tow," said the hotel's Master Naturalist Randy Sarton, who oversees the center. "It's great to see that they've learned something."

domain: biology


text:
Coroner IDs man struck by Metro A Line train in South Los Angeles
The Coroner’s Office on Saturday released the name of a 54-year-old man who was struck and killed by a Metro A Line train in the Florence-Firestone area of Los Angeles County.
The man was identified as Herculano Marcial Garcia, of Los Angeles, according to the coroner’s office.
Garcia was hit about 11 a.m. Friday at the rail crossing near Gage and Holmes avenues, according to the Los Angeles County Sheriff’s Department’s Transit Services Bureau.
He was pronounced dead at the scene.
Rail service was interrupted on the A Line, formerly known as the Blue Line, between the Florence and the Slauson stations, and bus shuttles were arranged to assist rail passengers. The investigation was continuing.


A security researcher has discovered a vulnerability that allows websites to track users across a number of different desktop browsers — including Apple Safari, Google Chrome, Microsoft Edge, Mozilla Firefox and Tor — posing a threat to cross-browser anonymity.
Called “scheme flooding,” the flaw “allows websites to identify users reliably across different desktop browsers and link their identities together,” Konstantin Darutkin, a researcher and developer at FingerprintJS, said in a blog post published Thursday. FingerprintJS is the publisher of a well-known browser-fingerprinting API.
The vulnerability uses custom URL schemes as an attack vector — hence its name, he explained in the post. It can assign someone a permanent unique identifier using information about installed apps on that person’s computer — even if he or she switches browsers, uses incognito mode or accesses the internet through a VPN.
“Cross-browser anonymity is something that even a privacy-conscious internet user may take for granted,” Darutkin said in his post. “A website exploiting the scheme-flooding vulnerability could create a stable and unique identifier that can link those browsing identities together.”
For instance, someone may use the Tor browser because it’s known for being “the ultimate in privacy protection;” however, it’s not as fast or high-performing as other browsers, so someone may opt to use Safari, Firefox or Chrome for some sites, and Tor when engaging in anonymous browsing activities — but the bug blows that anonymity out of the water, Darutkin explained.
How It Works
The vulnerability allows an attacker to determine which applications someone has installed by generating a 32-bit cross-browser device identifier that a website can use to test a list of 32 popular applications. This identification process — which checks to see if each one is installed on a computer or not — takes a few seconds and works across desktop Windows, Mac and Linux OS, he said.
To achieve this verification, browsers can use built-in custom URL scheme handlers — also known as deep linking, which is widely used on mobile devices but also available on desktop browsers as well, Darutkin explained. The feature is illustrated like this: If someone has Skype installed and types “skype://” in a browser address bar, the browser will open and ask if the user wants to launch Skype, he said.
“Any application that you install can register its own scheme to allow other apps to open it,” Darutkin said.
Exploiting the vulnerability takes four steps:
- Prepare a list of app URL schemes to test;
- Add a script on a website that will test each app;
- Use this array to generate a permanent cross-browser identifier;
- And, as an option to glean more info about a website visitor, use algorithms to guess that user’s occupation, interests and age using installed application data.
While all well-known browsers generally have mechanisms in place to prevent exploitation of such a flaw, all of the ones affected have weaknesses that allow scheme flooding to work, Darutkin explained. He added that Chrome offers some protection against the vulnerability, and its developers seem to be the only ones who so far have acknowledged that it exists.
“Only the Chrome browser had any form of scheme-flood protection which presented a challenge to bypass,” Darutkin said. “It prevents launching any application unless requested by a user gesture, like a mouse click. There is a global flag that allows (or denies) websites to open applications, which is set to false after handling a custom URL scheme.”
Safari, on the other hand, was the easiest one to exploit, “despite privacy being a main development focus” of Apple’s browser developers, he noted.
“Safari doesn’t have scheme-flood protection, which allows the exploit to easily enumerate all installed applications,” Darutkin said.
The researcher said he submitted bug reports to the developers of Safari, Chrome and Firefox, as well as published a demo of the exploit and repositories of all source data in the hopes that fixes are imminent.
Join Threatpost for “Fortifying Your Business Against Ransomware, DDoS & Cryptojacking Attacks” – a LIVE roundtable event on Wed, May 12 at 2:00 PM EDT. Sponsored by Zoho ManageEngine, Threatpost host Becky Bracken moderates an expert panel discussing best defense strategies for these 2021 threats. Questions and LIVE audience participation encouraged. Join the lively discussion and Register HERE for free.


text:
Wholesale sales rose just 0.8% in March, following a similar rise in February. For the quarter, sales dropped almost 2% from Q1 2015. More importantly, inventory barely budged in either March or for the quarter. Rising just 0.2% in the latest month, that was the smallest yearly gain since June 2010. In Q1 overall, wholesale inventories were also practically unchanged from a year earlier.
With no inventory expansion, production levels have to contract further even though wholesale sales aren’t themselves declining significantly. Lack of growth in sales, however, is not the same as a rebound, which when combined with lack of inventory leaves the manufacturing sector still facing recession. Inventories normalizing with the present state of sales still leaves last year’s huge imbalance.
Inventory levels throughout the wholesale piece of the supply chain continue to be highly elevated. Accounting for petroleum, we still find inventory levels that have only kept pace with sales, again as yet cutting into last year’s bloat. This might be the most significant aspect since auto inventories account for the bulk of the non-petroleum build-up. Wholesale inventory-to-sales for motor vehicles rose yet again to a new high in March, still comparable only to the Great Recession in terms of imbalance.
That has to be the worst part of this slowdown, having taken out more than a year and a half already and all that was gained was inventories finally catching down to sales. The US economy remains without any momentum. Despite small positives in sales year-over-year, that only means that after having fallen in 2015 sales have not at all started to erase that decline while inventory has yet to actually contract. It is the slowdown economy that can only stagnate at best while waiting for the next cyclical turn (with inventory suggesting a recessionary chance).
Although sales rose month-over-month on a seasonally-adjusted basis, at just $430.7 billion that is slightly less than $431.3 billion estimated for February 2012. In other words, the economy continues to go nowhere (at best) now with less inventory to provide what little support might be left. That is especially true given the state of channel stuffing in motor vehicles, a sector that had been one of the few remaining bright spots.


|Member of the Ontario Provincial Parliament
September 6, 2012
|Preceded by||Elizabeth Witmer|
|Born||1969 (age 47–48)|
|Political party||New Democrat|
Catherine Fife (born c. 1969) is a politician in Ontario, Canada. She is a New Democratic member of the Legislative Assembly of Ontario who represents the riding of Kitchener—Waterloo. She has been an MPP since 2012.
Prior to entering politics, she spent 10 years with the Toronto District School Board as an educational assistant, a school community advisor and a settlement worker for new immigrants. She was the research coordinator for the Partnerships for Children and Families Project at Wilfrid Laurier University. She lives in Kitchener-Waterloo with her husband Dale and their two children.
Fife was elected to represent Waterloo/Wilmot as a trustee for the Waterloo Region District School Board in 2003, and was re-elected in 2006 and 2010.
In the 2007 provincial election, Fife ran as the New Democrat candidate in the riding of Kitchener—Waterloo. She came in third behind incumbent Progressive Conservative Elizabeth Witmer and Liberal candidate Louis Ervin.
After Witmer resigned to take a position with the Workplace Safety & Insurance Board, Fife ran in a by-election on September 6, 2012 to replace her. She defeated Progressive Conservative candidate Tracey Weiler by 3,748 votes. She was re-elected in the 2014 provincial election defeating Liberal candidate Jamie Burton by 3,843 votes.
She is the party's critic for Finance and the Treasury Board.
|Ontario general election, 2014: Kitchener—Waterloo|
|New Democratic||Catherine Fife||20,536||37.43||-2.44|
|Progressive Conservative||Tracey Weiler||14,450||26.34||-5.49|
|Total valid votes||54,860||100.00|
|Total rejected, unmarked and declined ballots||623||1.12|
|New Democratic hold||Swing||-4.29|
Ontario provincial by-election, September 6, 2012: |
Resignation of Elizabeth Witmer
|New Democratic||Catherine Fife||18,599||39.87||+23.20|
|Progressive Conservative||Tracey Weiler||14,851||31.83||-11.94|
|People's Political Party||Kevin Clarke||48||0.10|
|Total valid votes||46,653||100.00|
|Total rejected, unmarked and declined ballots||128||0.27|
|New Democratic gain from Progressive Conservative||Swing||+17.57|
|Ontario general election, 2007|
|Progressive Conservative||Elizabeth Witmer||20,748||40.84||-2.24|
|New Democratic||Catherine Fife||8,902||17.52||+6.58|
|Family Coalition||Louis Reitzel||598||1.18||-0.53|
|Total valid votes||50,803||100.00|
|Total rejected ballots||313|
- "Summary of Valid Ballots Cast for Each Candidate" (PDF). Elections Ontario. October 10, 2007. p. 7 (xvi). Retrieved 2014-03-02.
- "Summary of Valid Ballots Cast for Each Candidate" (PDF). Elections Ontario. September 6, 2012. p. 1. Archived from the original (PDF) on 2014-05-01.
- "Ontario NDP’s by-election win leaves majority outside Liberals’ grasp". The Globe and Mail, September 6, 2012.
- "General Election by District: Kitchener-Waterloo". Elections Ontario. June 12, 2014.
- Reevely, David (June 25, 2014). "Horwath sticks around, names NDP shadow cabinet".


The Leofoto MV Wand Series Video Monopods are perfect for mobile, high capacity support solutions in crowd-heavy environments unsuitable for tripod use. The new and innovative quick release/lock system allows for the MV series monopods to rapidly switch between three different modes while still maintaining a secure connection with the press release lock as well as the switch release lock. *(Long versions have elongated leg tubes for extra height)
The MV Wand Series video monopod can be quickly folded for compact carry with the flip leg locks. Combine the monopod with the BV-10 for the perfect ultra-mobile, video support system.
The included Leofoto VD-03 Monopod Base Support is constructed of solid aircraft grade aluminum and hard anodized for a durable finish. This base support features a top which accepts the MV Series Monopod quick-lock system, a mini-ballhead, three angle stops, rubber feet and a rubber monopod foot. Use this highly versatile design as a monopod base support or mount your setup to the top and use it as a mini table top tripod.Leofoto MV-324CL(Long) Monopod + VD-03 Base Support:
Extended height: 1800mm/ 70.86in
Folded height: 670mm/ 26.37in
Leg section: 4
Loading Capacity: 10kg/ 22lb
Weight: 1.2kg/ 2.64lb
This thing is great. It’s easy to set up, use and carry. I will not be without it while shooting, ever again.


US 7571667 B2
A power tong for use during installation and dismantling of pipes when drilling in the ground, such as is known from e.g. petroleum production, comprising a drive ring and at least one clamping device, where the clamping device is arranged to grip a pipe string, the power tong being equipped with a driving mechanism for rotation of the clamping device about the longitudinal axis of the pipe string, and where the clamping device communicates with a fluid supply via a swivel ring that encircles the drive ring.
1. A power tong for use during installation and dismantling of pipes when drilling in the ground, said power tong comprising a drive ring and at least one clamping device where the clamping device is arranged to grip a pipe string, the power tong being equipped with a driving mechanism for rotation of the clamping device about a longitudinal axis of the pipe string, and where the clamping device communicates with a fluid supply via a swivel ring that encircles the drive ring, and a plurality of the clamping devices are gathered in a group, where the group of clamping devices are removable from the drive ring;
the clamping device having at least one piston in a cylinder, the piston communicating with the fluid supply via the swivel ring that encircles the drive ring,
the cylinder and the piston are double acting, wherein a plus side of the piston is in communication with a first passage in the swivel ring; and a minus side of the piston is in communication with a second passage in the swivel ring.
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This application claims the benefit of PCT/NO04/00355, filed Nov. 19, 2004, which claimed the benefit of Norway Application No. 20035234, filed Nov. 25, 2003.
This invention regards a power tong. More particularly, it regards a power tong without a radial opening, the power tong being particularly well suited for use during installation of piping when drilling in the ground, such as is known from e.g. petroleum production. The tong has a swivel coupling surrounding the tong for transferring pressurized fluid from an external source of pressurized fluid to the tong when the tong rotates about the longitudinal axis of the pipe.
It is known, among other things from petroleum production, to use power tongs for installing and dismantling lengths of piping to or from a pipe string associated with a drilling rig. It is common to use mechanical pipe tongs that, following the screwing or unscrewing of a pipe joint, on the whole are moved horizontally away from the pipe string, the pipe string being located at the drilling centre of the drill rig.
This method is dependent on the power tong having a radial opening, whereby the power tong can be displaced in the horizontal plane when being removed from the pipe string.
Having this type of radial opening in a power tong that has to be able to rotate about the longitudinal axis of the pipe obviously complicates the design of the power tong. The opening weakens the structure surrounding the pipe considerably. As a result, the structure must be up-rated in order to accommodate the relatively large forces being transferred between the power tong and the pipe string. A relatively complicated mechanical device is required to close the radial opening when the power tong is in use, and in many cases also to transfer forces between the sides of the opening.
The object of the invention is to remedy or diminish at least one of the disadvantages of prior art.
The object is achieved in accordance with the invention, by the characteristics stated in the description below and in the following claims.
According to the invention the power tong is provided with an undivided drive ring enclosing the vertical central axis of the drilling centre. The drive ring has been given a relatively large inner diameter so as to allow movement of e.g. drilling tools having a considerably larger outer diameter than the pipe string, through the power tong.
The drive ring is rotatably supported in the power tong housing and is preferably driven in a manner that is known per se, by at least one hydraulic motor.
In the drive ring there is provided at least one pressurized fluid driven radially displaceable clamping device (clamp). Most preferably there is a plurality of clamps distributed around the pipe in two groups. Each group of clamps is removably attached to the drive ring, each group of clamps being arranged so as to allow it to be lifted out of the drive ring in connection with e.g. maintenance or movement of a large object through the power tong.
Pressurized fluid from a pressurized fluid system connected thereto is delivered to the fluid cylinders of the clamps via a swivel coupling that sealingly encircles the drive ring. The swivel ring of the swivel coupling is stationary with respect to the power tong housing.
It is greatly advantageous for the clamp in the inactive position to be retracted relative to the pipe string, among other things to prevent sparking between the pipe string and the clamps during drilling. Thus, in a preferred embodiment, the swivel coupling is provided with a first passage that communicates with the plus side of the fluid cylinders, a second passage that communicates with the minus side of the fluid cylinders, and also a drainage duct.
Preferably the parts of the clamps abutting the pipe have replaceable grippers. Gripper sets can be manufactured in different shapes and sizes, allowing them to be adapted to the pipe dimension in question and the desired geometry of engagement between the gripper and the pipe string. The invention allows the clamps to be moved relatively far back relative to the pipe string.
In a preferred embodiment the power tong constitutes an upper installation tong in a joint assembly with an underlying back-up tong. The joint assembly is connected to a horizontally displaceable chassis by means of vertical guides, to allow the joint assembly to be moved away from the drilling centre.
The heights of the power tong and the back-up tong are mutually adjustable to compensate for the relative axial displacement of the pipes during screwing and unscrewing, and in order to allow work to be carried out between the tongs. Preferably weight-compensating cylinders are provided between the power tong and the back-up tong in order to take up weight when screwing sensitive threads.
Most preferably there is provided between the power tong and the back-up tong a collecting device for drilling fluid. The collecting device is connected to a mud outlet.
Preferably the back-up tong can be provided with a traversing lifting device on the underside, to make it possible to lift e.g. the slips etc.
The time it takes to tie in and dismantle pipes will be reduced when compared with prior art, as the time spent moving the power tong to and from the drilling centre no longer applies. The comparatively simple construction of the power tong results in improved reliability and lower maintenance costs.
All spinning and force operations are performed by use of the tong, so there is no need to use a separate so-called spinner.
The structure is compact and does not require a lot of space in the longitudinal direction of the pipe string. It is well suited for building in cleaning and lubricating equipment for the pipe thread.
The following describes a non-limiting example of a preferred embodiment illustrated in the accompanying drawings, in which:
In the drawings reference number 1 denotes a joint assembly of a power tong 2 and a back-up tong 4 located on a drilling rig 6 coaxially with the drilling centre 8 of the drilling rig 6. The assembly 1 is coupled in a vertically displaceable manner to two guide columns 10 arranged diametrically opposite each other relative to the drilling centre 8.
The guide columns 10 are connected to a chassis 12 which by means of wheels 14 and hydraulic motors (not shown) can be displaced horizontally on rails 16 connected to the drilling rig 6.
Thus, in the operative position the assembly 1 is located immediately above the slips 18 of the drilling rig 6, a pipe string 20 projecting up through the slips 18 and on up through the assembly 1. The pipe string 20 consists of screwed-together lengths 22 of piping.
The power tong 1, see
A cover 36 is provided to cover the power tong housing 24.
In the drive ring 30 and co-rotating with this are two crescent-shaped groups 38 of clamps, of which only one is shown in the drawings, for illustrative purposes.
Each group 38 of clamps is typically provided with three clamps 40 distributed around the drilling centre 8. A clamp 40 comprises a cylinder block 42 provided with three cylinder bores 44 arranged in a vertical row. In each cylinder bore 44 is a corresponding axially displaceable piston 46 that seals against the cylinder bore 44 by means of a piston gasket 48. A rear gasket 50 prevents pressurized fluid from flowing out between the piston 46 and the cylinder bore 44 at the rear end of the piston 46.
The pistons are removably attached to the housing 52 of the group 38 of clamps by means of respective screw-bolt-joints 54.
On the part of the cylinder block 42 facing the drilling centre 8 there is provided a gripper 56. The gripper 56 may be connected to the cylinder block 42 by means of dovetail grooves or screw-bolt-joints (not shown).
Surrounding the drive ring 30 there is provided a swivel ring 60 that seals by means of swivel gaskets 58, the swivel ring 60 being stationary relative to the power tong housing 24. The swivel ring 60 has a first passage 62 that communicates with the plus side of the pistons 46 via a first fluid connection 64, a second passage 66 that communicates with the minus side of the pistons 46 via a second fluid connection 68, and a further passage 70. The cylinder 44 and the piston 46 are thereby double acting.
The swivel ring 60, swivel gaskets 58 and drive ring 30 together form a swivel coupling.
The back-up tong 4 comprises a back-up tong housing 74 with guides 76 that correspond with the guide columns 10, and a retainer ring 77 for two groups of clamps (not shown in this drawing). At the guides 76 there are cogwheels 78 that mesh with respective pitch racks 80 of the guide columns 10, see
Separate hydraulic motors 82 drive the cogwheels 78 via gears 84.
A pair of hydraulic cylinders 86 are arranged to adjust the vertical distance between the power tong 2 and the back-up tong 4.
A collecting device comprises a collecting bellows 90, see
The collecting device is drained via a pipe 96 to a vacuum tank 98, see
When a length 22 of piping is to be joined to the pipe string 20 the assembly 1 is displaced vertically along the guide columns 10 by means of the hydraulic motors 82, the gears 84, the cogwheels 78 and the pitch racks 80 until the back-up tong 4 corresponds with the upper socket part (not shown) of the pipe string 20 in a known manner. The vertical distance between the back-up tong 4 and the power tong 2 is adjusted so as to make the grippers 56 correspond with the lower socket part of the length 22 of piping.
The clamps 40 are moved up to the length of piping by pressurized fluid flowing to the first passage 62 in the swivel ring 60 and on through the first fluid connection 64 to the plus side of the pistons 46. The excess fluid on the minus side of the pistons 46 flows via the second fluid connection 68 and the second passage 66 back to a hydraulic unit (not shown).
The grippers 56 then grip their respective piping sections while the hydraulic motors 34 rotate the drive ring 30 and the groups 38 of clamps about the drilling centre 8, while at the same time constant pressure is applied through the swivel ring 60 to the plus side of the pistons 46.
The power tong 2 is displaced down towards the back-up tong 4 while the screwing takes place.
After the desired tightening moment has been achieved, the rotation of the drive ring 30 is stopped. The clamps 40 are retracted from the pipe string 20 by pressurized fluid being delivered to the minus side of the pistons 46 via the swivel ring 60.
Thus the joint assembly 1 is released from the pipe string 20 to be displaced to its lower position if desired, see
When a length 22 of piping is to be detached from the pipe string 20 the operation is performed in a similar manner to that described above. The collecting bellows 90 collects drilling fluid that is present in the length 22 of piping, and which flows out when the length 22 of piping is disconnected. The collected fluid flows via pipe 96 to the vacuum tank 98.
When drilling tools or other objects of a larger outer diameter than the pipe string 20 are to be displaced through the assembly 1, the grippers 56 can easily be removed from their respective clamps 40, or alternatively the groups 38 of clamps can be lifted out of the drive ring 30.
Weight-compensating cylinders 104 may be provided between the power tong 2 and the back-up tong 10 in order to take up weight when screwing sensitive threads. A schematic representation of these weight-compensating cylinders 104 is shown in
The back-up tong 10 may also be provided with a traversing lifting device 106 on the underside, to make it possible to lift. e.g., the slips. etc. A schematic representation of a traversing lifting device 106 is shown in


Loc: Rochester,NY,UNITED STATES
Maybe... ;)There is a guy in town who bought the first one I built just like this one and he has been recording and playing out with it a lot. He is a licensed musician for the Boston Red Sox via reverbnation as well and is coming out with a new album soon. He uses that guitar a lot and is a much better player than I am. He is also an official Taylor Acoustic Guitar endorser. You can search him on Facebook and his name is Mike Gladstone.


text:
The Emotionally Absent Mother A Guide to SelfHealing
Was your mother too busy, too tired, or too checked-out to provide you with the nurturing you needed as a child? Men and women who were “undermothered” as children often struggle with intimate...read more
Average Customer Rating
4.7 out of 5|
Was your mother too busy, too tired, or too checked-out to provide you with the nurturing you needed as a child? Men and women who were “undermothered” as children often struggle with intimate relationships, in part because of their unmet need for maternal care. The Emotionally Absent Mother will help you understand what was missing from your childhood, how this relates to your mother’s own history, and how you can fill the “mother gap” by:
- Examining the past with compassion for yourself and your mother
- Finding the child inside of you and learning to mother yourself
- Opening to the archetype of the Good Mother
- Allowing friends and loved ones to provide support, guidance, and other elements of good mothering that you missed
Through reflections, exercises, and clear explanations, psychotherapist Jasmin Lee Cori helps adult sons and daughters heal the wounds left by mothers who failed to provide the essential ingredients that every child needs. She traces perceived personal “defects” back to mothering deficits, relieving self-blame. And, by teaching today’s undermothered adults to cultivate the mothering they missed, she helps them secure a happier future—for themselves and their children. ....read more
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domain: psychology


Epson Smart Eyewear MOVERIO Pro BT-2000 Smart Headset
Optimised for Enterprise Usage
Featuring a series of technology and design innovations designed specifically for the industrial workplace, the revolutionary BT-2000 smart headset is poised to improve operational efficiency and ultimately change how work gets done.
Explore the Features of the BT-2000 Smart Headset
Experience a Smarter Workplace
The Epson Moverio Pro BT-2000 Smart Headset was designed for advanced augmented reality applications, remote field support, and any hands-free applications that require an industrial strength smart eyewear solution.Watch Video
The 5 Mega-pixel stereo camera supports gesture recognition & 3-D mapping
Industrial Grade IMU Sensor
Provides precise spatial orientation for indoor navigation
Binocular, Transparent Lenses
960x540 qHD display. Visual display is at 4m, 20% closer than the BT-200.
At 1350cd/m2, the BT-2000 is 1.5x brighter than the BT-200
Android-based Control Unit
Programmable Function Keys
Customize the controller to support specific job functions. Designed to support usage with gloves.
Onboard, Local Voice Control
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2.4 & 5GHz WiFi; Bluetooth 3.0 & BLE1
Hot Swappable Battery
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Adjustable headband and forehead pad for a more comfortable fit. No pressure applied on the nose.
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Can be worn over bump caps2
Move the display from your field of view without taking them off


text:
Plot of Ek Hazarachi Note
In this exploration of money and conscience, a poor woman receives a thousand-rupee note from a politician at election time, but the note proves to be a mixed blessing.
|Movie:||Ek Hazarachi Note|
|Cast:||Devendra Gaikwad, Usha Naik, Pooja Nayak, Sandeep Pathak, Shekhar Sathe|
|Rotten Tomatoes Score:||80%|
|Countries Available in:|