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Mikko Ilonen (pictured) won his fourth European Tour title by completing a wire-to-wire victory at the Irish Open at Fota Island Resort. Ilonen carded a final round of 70 to finish with a 13-under par victory total, one shot clear of his nearest competitor. Ilonen played with the Titleist Pro V1x ball and carded a final round of 70 to finish with a 13-under par victory total, one shot clear of his nearest competitor. He was wearing FJ Icon shoes and an FJ StaSof glove.
Across the Atlantic, Kevin Streelman made seven consecutive birdies in a final round 64, completing a one stroke victory at the Travelers Championship. Streelman finished on a 15-under par, 265 winning total, to secure the second PGA Tour title of his career. He also played the Titleist Pro V1x ball and wore FJ Sport shoes and an FJ SciFlex glove.


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HEALTH & SAFETY PROTOCOLS
We are committed to your health and wellbeing.
UTSA is committed to fostering a safe learning, working and living environment for our Roadrunner community. As part of our shared responsibility to do our part, the university’s Recovery Operations Team coordinates the universities operational response to COVID-19 and is expanding to oversee the response to the Monkeypox outbreak.
The Recovery Operations Team continually assesses local risk levels. Under guidance from resources including the CDC, State of Texas, UT System and San Antonio Metro Health, the team makes recommendations for adjustments to campus operations, protocols and procedures as needed. UTSA Housing and Residence Life leadership are active members of the Recovery Operations Team.
Here are updated operations and policies for the 2022-2023 academic year.
UTSA-managed housing facilities will remain open to all residents regardless of the method of instruction and will continue to follow public health and safety directives issued by UTSA. UTSA will make policy adjustments and implement additional measures as necessary. Any updates to housing policies will be posted to this webpage.
DO YOUR PART
We have a shared responsibility to take steps to minimize the spread of infectious disease and infections on our campus. COVID-19 and Monkeypox are two currently active examples, but this applies to the spread of many public health risks. This means adhering to national, state, and local health guidelines and requirements, as well as those measures we deem safe and appropriate for UTSA. Every member of our Roadrunner community – including you – must do their part.
Visit the Recovery Operations website for information regarding COVID-19 and Monkeypox.
RISK REDUCING STRATEGIES
- In residential buildings, face coverings are strongly encouraged in public areas, particularly when social distancing cannot be maintained.
- Maintain good hygiene habits.
- Maintain social distance according to CDC guidelines.
- Carry a personal hygiene pack containing a face covering, hand sanitizer, disinfecting wipes, and tissues.
- Clean and wipe down surfaces with suitable cleaning agents after use.
- Practice physical distancing while doing laundry in the laundry room. Clean and wipe down surfaces with suitable cleaning agents after using equipment.
WHAT TO DO IF YOU ARE EXPERIENCING SYMPTOMS
Visit Recovery Operations for information regarding COVID-19 as well as Monkeypox.
- Step 1 – Immediately begin practicing Risk Reducing Strategies, particularly avoiding direct contact with roommates.
- Step 2 – Stay home from school.
- Housing and Residence Life encourages residents to isolation / quarantine off-campus at home or alternative location whenever possible.
- Step 2 – Test!
- COVID-19 testing options are located on the Recovery Operations testing page. Submit COVID-19 test results through the campus portal.
- UTSA students exposed to someone with monkeypox or who are experiencing symptoms should contact Wellness 360 or their personal health care provider.
- Step 3 – Follow guidance from your health care provider.
- Step 4 – Wear a face mask and avoid direct contract with others.
- Step 5 – Stay home and follow CDC isolation guidance.
MONKEYPOX INFORMATION AND RESOURCES
Monkeypox is a rare disease caused by infection with the monkeypox virus. It is part of the same family of viruses as variola virus, the virus that causes smallpox. While symptoms are similar to smallpox, they are typically milder and rarely fatal. Visit the Monkeypox Information and Resources page for updates regarding monkeypox signs, symptoms and how monkeypox spreads.
- UTSA will work on a case-by-case basis with individuals diagnosed with the monkeypox virus.
- Residents testing positive for monkeypox should plan to isolate off-campus at home or at another location for the duration of the illness. Isolation typically lasts two to four weeks. While we are recommending isolation at home, UTSA will try to assist students that are not able to isolate away from campus.
- If you are unable to remain fully isolated throughout the illness, follow the CDC’s prevention practices for each stage of the illness.
- Wear a well-fitting disposable mask over nose and mouth
- Cover any skin lesions with long pants and long sleeves or bandages
- Use trash bags to store soiled clothing and linens.
- Store trash securely in trash bags and deposit bags directly in waste receptacles.
- Return to campus / resume activity only after all symptoms have resolved. Notify Housing and Residence Life to update your status at the end of isolation.
WHAT HAPPENS IF YOU DO NOT COMPLY
- Each student is responsible for reviewing and abiding by the policies in place at UTSA.
- Students found to be non-compliant with the any UTSA Policies, including public health operating procedures or requirements, may be referred to the Student Conduct Process.

domain: health


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|Preparation time||10 minutes|
|Serving Size||1 egg|
|Calories Per Serving||Approximately 111 per serving|
salt to taste
pepper to taste
1 teaspoon oil to coat the pan
1.Heat oil in a pan,put enough to coat the pan.
2.Crack the egg on the hot pan, turn down the flame to medium and let cook for about 20 seconds.
3.Lightly jiggle the pan to make sure the eggs are not sticking to the pan.Now with a spatula or directly with the pan gently flip the eggs.Cook for 1 more minute and slide onto your plate.
If you are comfortable flipping eggs with the pan itself without using the spatula, do so but make sure the eggs slide towards the end of the pan and catch them immediately,do not flip them too high or the yolk will break.
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domain: food


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The teenage years can be challenging, but finding support and connection can make all the difference. Teen support groups provide a safe space for adolescents to share their experiences, challenges, and triumphs with peers who understand. Teen support groups foster connections, ultimately empowering teens by helping them discover the transformative power of finding their tribe.
The Need for Connection
Adolescence is a time of self-discovery, and teenagers often seek a sense of belonging and understanding. Teen support groups fulfill this need by creating a community of like-minded individuals facing similar struggles. By connecting with peers who can relate to their experiences, teenagers find comfort, validation, and a supportive network that can positively impact their emotional well-being.
A Safe Space for Sharing
Teen support groups provide a safe and confidential environment where adolescents can openly express themselves without fear of judgment. Through group discussions and activities facilitated by trained professionals, participants are encouraged to share their thoughts, feelings, and challenges. This sharing fosters a sense of trust and solidarity within the group, allowing teenagers to explore their emotions, gain new perspectives, and develop empathy for others.
Empowerment through Shared Experiences
Within teen support groups, participants realize they are not alone in their struggles. Sharing similar experiences and hearing others’ stories of resilience and growth can be incredibly empowering. Through these shared experiences, teenagers gain insights, coping strategies, and encouragement from their peers. They learn that their challenges and failures do not define them, and that they have the strength to overcome obstacles. This empowerment promotes self-confidence, resilience, and a sense of agency in their lives.
Building Lifelong Connections
Teen support groups offer a unique opportunity to build lasting friendships and connections. Adolescents bond over shared experiences and develop a sense of camaraderie as they navigate the ups and downs of adolescence together. The connections formed within these groups often extend beyond the group sessions, providing teenagers with a support network they can potentially rely on even after their participation ends. These relationships can be a source of ongoing encouragement, understanding, and growth.
The Impact on Emotional Well-being
Research shows that participating in teen support groups can have a significant positive impact on teenagers’ emotional well-being. By providing a space for self-expression, support groups contribute to reduced feelings of isolation, anxiety, and depression. Teens may develop improved coping skills, enhanced self-esteem, and a greater sense of belonging.
Teen Support Groups at Insight Treatment
Teen support groups play a vital role in fostering connection and empowerment among adolescents. By providing a safe space for sharing, understanding, and support, these groups can have a profound impact on teenagers’ emotional well-being and overall development. To learn more about how our support groups could potentially benefit your teen, reach out to us today.

domain: sociology


The mission of the Duncanville ISD Counseling Department is to reach the hearts of students every day so that they can be their best selves.
The vision of the Duncanville ISD Counseling Department is to graduate all students with a clear post-secondary plan and the social-emotional skills to succeed in a competitive environment.
- I believe all students can achieve greatness in a safe and nurturing environment.
- I believe all students deserve the opportunity to receive a high-quality education.
- I believe all counselors are advocates for students, their families, and the school community.
I am Felica Horne, and I am the School Counselor at Merrifield Elementary. This is my 17th year in the field of education. My greatest joy in life is impacting lives by helping our students believe in themselves and find their strengths.
As the school counselor, I will provide a variety of services to our students, teachers, and support staff. These services include but are not limited to: Individual Counseling, Small Group Counseling, Guidance Lessons, Teacher/Parent Consultations, and Community Resource Referrals.
I look forward to partnering with you to continue Merrifield Excellence!


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Cor Bruijn, Jason en het Gulden Vlies “Jason and the Golden Fleece”
Getting this book from the library in my very early teens was part of the reason that I wanted to go to grammar school. (And never regretted that I did — my Greek curriculum was much more Homer-oriented than that of my daughter who is doing Greek in grammar school now, and we read whole chapters of the Iliad and the Odyssey.)
Reading this version again was a strange experience. Parts were as glowingly mythical as I remembered, and parts were –well, intentionally over the head of children, I suppose. And indeed, the author says in the afterword “I did not recount everything that is known about [the voyage of the Argo]. I left out episodes I thought were less important, and added a few elements –for instance, the relationship between Jason and Hypsipyle– to make the story more acceptable to the modern reader” (emphasis mine). I think I could do a close reading on the whole book and find all the places where he made the story more acceptable to the modern reader; and I suppose I’m not a modern reader in that case. He also left out the horror story about Medea and had her and her sons stoned to death instead, explaining that different sources have different versions and he picked the one he preferred. I don’t know which one I prefer (I remember reading the other version somewhere else), whether I’d rather have Medea evil or unhappy.
But yes, my eleven-year-old self was cheering on Jason and the Argonauts the same way as on her first reading. She at least, with teenage coarseness, prefers Medea evil.
One thing I don’t remember having noticed the first time (granted, it’s forty years ago): Pelias sent them to Colchis to retrieve Phrixos‘ bones and incidentally get the Golden Fleece; they left with the Golden Fleece, with Aietes in hot pursuit, without even thinking of Phrixos’ bones until they got back to Pelias. This time I said “wait! what about Phrixos’ bones?” the moment they were fleeing, perhaps because I’ve been writing a lot myself in those forty years and I’ve acquired an antenna for continuity.

domain: library


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Miniature Dollhouse 1:12 Scale | Farmhouse Kitchen Lower Cabinet 3cm
Made of wood hand painted with white chalk paint. Please note the drawers do not open they are only false. The top is matte acrylic & matches all of our new kitchen collection.
7.6cm high and 4.8cm deep
Please also note that items in the background are not included - they are used for styling purposes only
Subscribe today to recieve new minis to your inbox!

domain: hobby


Posted by 03 April 2019
Birth control has emerged as a contentious issue in the wake of the Affordable Care Act’s contraception mandate. Now two senators want women to be able to buy birth control pills without a prescription.
Senator Joni Ernst, a Republican from Iowa, and Sen. Cory Gardner, a Republican from Colorado, have introduced S. 930. This legislation would not directly remove the current Food and Drug Administration rule requiring a prescription to access the drug, since Congress does not have the power to do this. It would, however, expedite the process of moving the drug to over-the-counter usage.
Currently, the process could take up to five years. There is some interest among drug companies for applying to petition the FDA to do this. If this legislation becomes law, it would give priority to such applications.
Some states currently allow pharmacists, rather than doctors, to write a prescription for birth control pills. That makes them easier to get, but not as easy as if they were approved for over-the-counter sales.
Do you think that the federal government should allow birth control pills to be sold over the counter?


What an amazing concert and performance by Desert Rose was experienced by the appreciative audience that braced the Cape Doctor and snuggled into their blankets on the lawn of the LifeShine Wellness Centre.
Desert Rose, widely regarded as international leaders in creating music and performances of sacred healing music, staged a live local performance at the Lifeshine Wellness Centre on 28th November 2020. The sacred musical duo, Lynne and Yusuf, having toured the USA, Malaysia, India and Mozambique before lockdown, did not disappoint the local fans with their offering of sound healing in this beautiful setting.
Not even the blustery conditions dampened the beautiful sounds that resonated across the Helderberg valley with the moon rising to the Epitah as the crowd was transported to a spiritual paradise of their own making and entered a state of deep relaxation, whilst enjoying healthy food hampers from our restaurant Aura of Eden.
For a while everyone found themselves in the calmness of divine love in the middle of the chaos that surrounds us in these strange times and Desert Rose's spirited voice and music took all that encountered this enchanting performance to a quick journey of connection to love.
This is where the synergy of Desert Rose music and modalities of LifeShine Wellness Center converge - deep relaxation is vital to a healthy body, mind and spirit; it is when true healing takes place at acellular level increasing immunological and organ function through synchronised breathing and heart beat, taking the listener to a sacred place.
We cannot wait for the next rendition of their beautiful sounds and music at LifeShine to take us all into the infinite realm of the inner world.


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Action And Clinical Pharmacology: Melphalan is an alkylating agent of the bischloroethylamine type. As a result, its cytotoxicity appears to be related to the extent of its interstrand cross-linking with DNA, probably by binding at the Nposition of guanine. Like other bifunctional alkylating agents, it is active against both resting and rapidly dividing tumor cells.
Pharmacokinetics: The pharmacokinetics of melphalan after i.v. administration have been extensively studied in adult patients, and linear pharmacokinetics were observed over a broad dose range (5 to 220 mg/m. Following injection, drug plasma concentrations declined rapidly in a biexponential manner with distribution phase and terminal elimination phase half-lives of approximately 10 and 70 minutes, respectively. Estimates of average total body clearance varied among studies, but typical values of approximately 7 to 9 mL/min/kg (250 to 325 mL/min/m were observed. Mean (±SD) peak melphalan plasma concentrations in myeloma patients given melphalan i.v. at doses of 10 or 20 mg/mwere 1.2±0.4 and 2.8±1.9µg/mL, respectively. Studies in children as young as 1 year showed results similar to adults.
The steady-state volume of distribution of melphalan is 0.5 L/kg and approximates total body water. Penetration into cerebrospinal fluid (CSF) is low, with plasma/CSF concentration ratios reported from 10:1 to greater than 100:1. The extent of melphalan binding to plasma proteins is moderately high with reports ranging from 60 to 90%. Serum albumin is the major binding protein, while a-acid glycoprotein appears to account for about 20% of the plasma protein binding. Interaction with immunoglobulins have been found to be negligible.
Melphalan is eliminated from plasma primarily by chemical hydrolysis to monohydroxy- and dihydroxy-melphalan. Aside from these hydrolysis products, no other melphalan metabolites have been observed in man. Although the contribution of renal elimination to melphalan clearance is low and most investigators have observed no relationship between renal dysfunction and melphalan pharmacokinetics, one study noted an increase in the occurrence of severe leukopenia in patients with elevated BUN after 10 weeks of therapy.
The pharmacokinetics of melphalan administered by closed circuit limb perfusion have been studied by several investigators. Melphalan concentrations declined rapidly and biexponentially from circulating perfusate with average terminal half-lives reported from 26 min (n=4) to 53 min (n=48). Systemic exposure to melphalan during limb perfusion is generally very low. Peak melphalan concentrations in the closed circuit perfusate are typically 10 to 100 times greater than peak concentrations in plasma observed following standard dose systemic i.v. therapy for multiple myeloma.
Indications And Clinical Uses:
Caution: There are many reports of patients with multiple myeloma who have developed acute, non-lymphatic leukemia or myeloproliferative syndrome following therapy with alkylating agents (including melphalan). Evaluation of published reports strongly suggests that melphalan is leukemogenic in patients with multiple myeloma.
There is a greatly increased incidence of acute, non-lymphatic leukemia in women with ovarian carcinoma treated with alkylating agents (including melphalan).
Melphalan is a carcinogen in animals and must be presumed to be so in humans. Although the palliation to be anticipated from the use of melphalan in multiple myeloma and ovarian carcinoma is generally felt to greatly outweigh the possible induction of a second neoplasm, the potential benefits and the potential risk of carcinogenesis must be evaluated on an individual basis.
Melphalan has been observed to produce chromosomal aberrations in human cells in vitro and in vivo. Melphalan is potentially mutagenic and teratogenic in humans, although the extent of the risk is unknown.
Melphalan is indicated for the palliative treatment of multiple myeloma and for the palliation of non-resectable epithelial carcinoma of the ovary.
Malignant Melanoma: Melphalan for injection has been administered by hyperthermic isolated limb perfusion as an adjuvant to surgery. However, there have been no prospective controlled or uncontrolled trials evaluating dose and its relationship to disease response and/or toxicity.
Contra-Indications: Melphalan should not be used in patients whose disease has demonstrated a prior resistance to this agent. Patients who have demonstrated hypersensitivity to melphalan should not be given the drug. There may be cross-sensitivity (skin rash) between melphalan and chlorambucil.
Melphalan should not be given if other similar chemotherapeutic agents or radiotherapy have been administered to the patient recently or if neutrophil and/or platelet counts are depressed.
Melphalan should not be administered concurrently with radiotherapy.
Manufacturers’ Warnings In Clinical States:
Melphalan should be administered in carefully adjusted dosages by or under the supervision of experienced physicians who are familiar with the drug’s actions and the possible complications of its use.
The major acute toxicities are related to bone marrow suppression, hypersensitivity reactions including anaphylaxis, gastrointestinal disturbances and pulmonary toxicity. The major long-term toxicities are related to infertility and secondary malignancies. Melphalan is leukemogenic and potentially mutagenic in humans.
Careful attention should be paid to the monitoring of blood counts. Patients with renal impairment should be closely observed as they may have uremic marrow suppression.
The drug should not be administered by hyperthermic isolated limb perfusion unless the clinician is experienced and well-trained in this technique.
As with other nitrogen mustard drugs, excessive dosage will produce marked bone marrow suppression. Bone marrow suppression is the most significant toxicity associated with melphalan for injection in most patients. Therefore, the following tests should be performed at the start of therapy and prior to each subsequent dose of melphalan: platelet count, hemoglobin, WBC count and differential. The occurrence of a platelet count below 50 000/mmor an absolute neutrophil count below 500/mmis an indication to withhold further therapy until the blood counts have sufficiently recovered. Frequent blood counts are essential to determine optimal dosage and to avoid toxicity.
Acute hypersensitivity reactions, including anaphylaxis, have occurred infrequently (see Adverse Effects). Treatment is symptomatic. The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician.
Secondary malignancies, including acute nonlymphocytic leukemia, myeloproliferative syndrome, and carcinoma, have been reported in patients with cancer treated with alkylating agents (including melphalan). Some patients also received other chemotherapeutic agents or radiation therapy. Precise quantitation of the risk of actue leukemia, myeloproliferative syndrome or carcinoma is not possible. Published reports of leukemia in patients who have received melphalan (and other alkylating agents) suggest that the risk of leukemogenesis increases with chronicity of treatment and with cumulative dose. In one study, the 10-year cumulative risk of developing acute leukemia or myeloproliferative syndrome after melphalan therapy was 19.5% cumulative doses ranging from 730 mg to 9 652 mg. In this same study, as well as in an additional study, the 10-year cumulative risk of developing acute leukemia or myeloproliferative syndrome after melphalan therapy was less than 2% for cumulative doses under 600 mg. This does not mean that there is a cumulative dose below which there is no risk of the induction of secondary malignancy. The potential benefits from melphalan therapy must be weighed on an individual basis against the possible risk of the induction of a second malignancy.
Melphalan has been shown to cause chromatid or chromosome damage in man. Melphalan causes suppression of ovarian function in premenopausal women, resulting in amenorrhea in a significant number of patients. Reversible and irreversible testicular suppression have also been reported.
Lactation: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from melphalan, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Precautions: General: In all instances where the use of melphalan for injection is considered for chemotherapy, the physician must evaluate the need and usefulness of the drug against the risk of adverse events. Melphalan should be used with extreme caution in patients whose bone marrow reserve may have been compromised by prior irradiation or chemotherapy, or whose marrow function is recovering from previous cytotoxic therapy. Dose reduction should be considered in patients with renal insufficiency receiving i.v. melphalan. In one trial, increased bone marrow suppression was observed in patients with BUN levels ³30 mg/dL. A 50% reduction in the i.v. melphalan dose decreased the incidence of severe bone marrow suppression in the later portion of this study.
If the leukocyte count falls below 3 000 cells/µL, or the platelet count below 100 000/µL, the drug should be discontinued until the blood picture has had a chance to recover.
Blood counts may continue to fall for 6 to 8 weeks after initiation of treatment, So, at the first sign of an abnormally large fall in leukocyte or platelet counts, treatment should be temporarily interrupted.
Patients with azotemia should be closely observed, however, in order to make dosage reductions, if required, at the earliest possible time.
Laboratory Tests: Periodic complete blood counts with differentials should be performed during the course of treatment with melphalan. At least one determination should be obtained prior to each dose. Patients should be observed closely for consequences of bone marrow suppression, which include severe infections, bleeding, and symptomatic anemia (see Warnings).
Pregnancy: Safe use of melphalan has not been established with respect to adverse effects on fetal development. Therefore, it should be used in women of childbearing potential and particularly during early pregnancy only when, in the judgment of the physician, the potential benefits outweigh the possible hazards.
Children: The safety and effectiveness in children have not been established.
Geriatrics: Clinical experience with melphalan has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Adverse Reactions: The following information on adverse reactions is based on data from both oral and i.v. administration of melphalan as a single agent, using several different dose schedules for treatment of a wide variety of malignancies.
Hematologic: Leukopenia, neutropenia and hemolytic anemia were observed. The most common side effect is bone marrow suppression. Irreversible bone marrow failure has been reported. Bone marrow suppression is uncommon after limb perfusion.
Blood Chemistry: Elevation in liver function enzymes is usually mild. An increase in urea and creatinine levels has been observed.
Gastrointestinal: Gastrointestinal effects such as nausea and vomiting occur in up to 30% of patients receiving conventional oral doses of melphalan and in up to 50% of patients receiving i.v. doses of melphalan. Diarrhea is noted to occur 1 week post high dose melphalan therapy. Oral ulceration and hepatic toxicity including veno-occlusive disease have been reported.
Hypersensitivity: Acute hypersensitivity reactions, including anaphylaxis, were reported in 2.4% of 425 patients receiving melphalan for injection for myeloma (see Warnings). These reactions were characterized by urticaria, pruritus, edema, and in some patients, tachycardia, bronchospasm, dyspnea, and hypotension. These patients appeared to respond to antihistamine and corticosteroid therapy. Treatment with melphalan should be discontinued if a hypersensitivity reaction occurs.
Local Reactions: Mild pain and/or irritation at, or near, the site of injection occurred after approximately half of the infusions, resolving within a few hours after the end of the injection, without a need for treatment. Skin ulceration at injection site and flushing were reported.
Miscellaneous: Other reported adverse reactions include: skin hypersensitivity, vasculitis, alopecia, allergic reaction, pulmonary fibrosis, and interstitial pneumonitis. Flushing sensations were reported at high doses of melphalan.
Symptoms And Treatment Of Overdose: Symptoms: Overdose as high as 290 mg/mresulting in death has been reported. It has also been reported that a pediatric patient survived a 254 mg/moverdose treated with standard supportive care. The immediate effects are severe nausea and vomiting. Decreased consciousness, convulsions, muscular paralysis and cholinomimetic effects are less frequently seen. Severe mucositis, stomatitis, colitis, diarrhea, and hemorrhage of the gastrointestinal tract occur at high dose (>100 mg/m. Elevations in liver enzymes and veno-occlusive disease occur infrequently. Nephrotoxicity and adult respiratory distress syndrome have been reported rarely. The principal effect is bone marrow suppression.
Treatment: Hematologic parameters should be closely followed for 3 to 6 weeks. Administration of autologous bone marrow or hematopoietic growth factors (i.e., sargramostim, filgrastim) may shortern the period of pancytopenia. General supportive measures together with appropriate blood transfusions and antibiotics should be instituted as deemed necessary by the physician. This drug is not removed from plasma to any significant degree by hemodialysis or hemoperfusion.
Dosage And Administration: Oral: Multiple Myeloma: The usual oral dose is 6 mg daily. The entire daily dose may be given at one time. It is adjusted, as required, on the basis of blood counts done at approximately weekly intervals. After 2 to 3 weeks of treatment, the drug should be discontinued for up to 4 weeks, during which time the blood count should be followed carefully. When the white blood cell and platelet counts are rising, a maintenance dose of 2 mg daily may be instituted. Because of the patient-to-patient variation in melphalan plasma levels following oral administration of the drug, several investigators have recommended that melphalan dosage be cautiously escalated until some myelosuppression is observed, in order to assure that potentially therapeutic levels of the drug have been reached.
Other dosage regimens have been used by various investigators. Osserman and Takatsuki have used an initial course of 10 mg/day for 7 to 10 days. They report that maximal suppression of the leukocyte and platelet counts occurs within 3 to 5 weeks and recovery within 4 to 8 weeks. Continuous maintenance therapy with 2 mg/day is instituted when the white blood cell count is greater than 4 000 and the platelet count is greater than 100 000. Dosage is adjusted to between 1 and 3 mg/day depending upon the hematological response. It is desirable to try to maintain a significant degree of bone marrow depression so as to keep the leukocyte count in the range of 3 000 to 3 500 cells/µL.
Hoogstraten et al have started treatment with 0.15 mg/kg/day for 7 days. This is followed by a rest period of at least 14 days, but it may be as long as 5 to 6 weeks. Maintenance therapy is started when the white blood cell and platelet counts are rising. The maintenance dose is 0.05 mg/kg/day or less and is adjusted according to the blood count.
Available evidence suggests that about one-third to one-half of the patients with multiple myeloma show a favorable response to oral administration of the drug. It is to be emphasized that response may be very gradual over many months; it is important that repeated courses or continuous therapy be given since improvement may continue slowly over many months and the maximum benefit may be missed if treatment is abandoned too soon.
Epithelial Ovarian Cancer: One commonly employed regimen for the treatment of ovarian carcinoma has been to administer melphalan at a dose of 0.2 mg/kg p.o. daily for 5 days as a single course. Courses are repeated every 4 to 5 weeks depending upon hematologic tolerance.
I.V.: Multiple Myeloma: The usual i.v. dose is 16 mg/m Dosage reduction of up to 50% should be considered in patients with renal insufficiency (BUN ³30 mg/dL). The drug is administered in one dose and the length of infusion should be from 15 to 90 minutes. Melphalan is repeated at 2-week intervals initially for 4 doses, then at 4-week intervals after adequate recovery from toxicity. Available evidence suggests about one-third to one-half of the patients with multiple myeloma show a favorable response to the drug. Experience with oral melphalan suggests that repeated courses should be given since improvement may continue slowly over many months, and the maximum benefit may be missed if treatment is abandoned prematurely. Dose adjustment on the basis of blood cell counts at the nadir prior to each dose should be considered.
Perfusion Method: Malignant Melanoma: Only physicians experienced and well-trained in hyperthermic isolated limb perfusion should administer the drug in this fashion. The recommended dose of melphalan for injection for hyperthermic limb perfusion for the treatment of locally advanced malignant melanoma of the extremity is 1.0 mg/kg body weight for upper extremity and 1.5 mg/kg for lower extremity. The total dose for a perfusion should not exceed 80 mg for upper extremity and 120 mg for lower extremity. As soon as hyperthermic conditions are achieved, melphalan for injection is administered into the arterial line of the perfusion in 3 equally divided doses at 5-minute intervals. The hyperthermic perfusion is continued for one hour after the administration of melphalan for injection. The surgical technique and procedure have been well-described. To exclude or minimize perfusion-related complications, the key perfusion variables should be followed: Temperature: perfusate and i.m./s.c. tissue should not exceed 42.5 and 42°C, respectively. Flow Rate: 250 to 400 mL/minute are generally used for auxiliary perfusions, 400 to 600 mL/minute for iliac perfusions. Perfusate: 650 to 750 mL volume consisting of either heparinized whole blood (2 000 units/500 mL) or a heparinized (2 000 units/500 mL) 50:50 mixture of Lactated Ringer’s and washed packed red blood cells. Perfusion Duration: not to exceed 1 hour. Dose: not to exceed 1 mg/kg for upper extremity (total dose £80 mg) and 1.5 mg/kg for lower extremity (total dose£120 mg) of melphalan for injection.
Preparation for Administration/Stability: I.V.: Reconstitute melphalan for injection, as directed, with 10 mL of the supplied diluent. This provides a 5 mg/mL solution of melphalan. Immediately dilute the dose to be administered in 0.9% sodium chloride injection, USP, to a concentration not greater than 2 mg/mL. Administer the diluted product over a minimum of 15 minutes. Complete administration within 50 minutes of reconstitution. Discard any reconstituted and diluted solutions remaining after 50 minutes of reconstitution.
The reconstituted product is stable for up to 2 hours at 30°C. A precipitate forms if the solution is stored at 5°C. Do not refrigerate.
Solutions diluted to a concentration of 0.1 mg/mL to 0.45 mg/mL in 0.9% sodium chloride injection are stable for up to 50 minutes at 30°C and 3 hours at 20°C.
Perfusion: Reconstitute melphalan for injection, as directed, with 10 mL of the supplied diluent. This provides a 5 mg/mL solution of melphalan. Administer the reconstituted melphalan directly into the arterial line of the perfusion in 3 equally divided doses at 5-minute intervals. Complete administration within 2 hours of reconstitution. Discard any portion remaining after 2 hours of reconstitution.
The reconstituted product is stable for up to 2 hours at 30°C. A precipitate forms if the solution is stored at 5°C. Do not refrigerate.
Reconstituted Solutions: Melphalan for injection must be reconstituted, at room temperature, by rapidly transferring 10 mL of the supplied solvent-diluent directly into the vial of lyophilized powder using a sterile needle (20 gauge or larger needle diameter) and syringe. Immediately shake vial vigorously until a clear solution is obtained. Rapid addition of the diluent followed by immediate vigorous shaking is important for proper dissolution. The pH of resulting solution is approximately 6.5.
Melphalan injection solution has limited stability and should be prepared immediately before use. Any unused solution should be discarded. The reconstituted solution should be used immediately and should not be refrigerated as this will cause precipitation. It is stable for up to 2 hours at 30°C.
Melphalan injection solution has reduced stability when further diluted in an infusion solution and the rate of degradation increases rapidly with rise in temperature. In that case, only Sodium Chloride Infusion, 0.9% w/v should be used. Solutions diluted to a concentration of 0.1 mg/mL to 0.45 mg/mL in 0.9% Sodium Chloride Infusion should be used immediately and are stable for up to 50 minutes at 30°C and 3 hours at 20°C.
Administration Precautions: Parenteral drug products should usually be inspected for particulate matter and discoloration prior to administration whenever solution and container permit. If either occurs, do not use this product.
As with other toxic compounds, caution should be exercised when handling and preparing the solution of melphalan. Skin reactions associated with accidental exposure may occur. The use of gloves is recommended. If the solution of melphalan contacts the skin or mucosa, immediately wash the skin or mucosa thoroughly with soap and water.
Availability And Storage: Injection: Each vial of sterile, white to cream-colored, freeze-dried powder contains: melphalan HCl equivalent to melphalan 50 mg and povidone 20 mg. Each vial of solvent-diluent provides 10 mL of buffer solution containing sodium citrate 0.20 g, ethanol 0.52 mL, propylene glycol 6 mL and water for injection, q.s. Component packs of 2 comprising a vial containing a freeze-dried powder and a vial of solvent-diluent. Store at controlled room temperature (15 to 30°C). Protect from light.
Tablets: Each white, scored tablet, imprinted ALKERAN and A2A on each side of the score, contains: melphalan 2 mg. Bottles of 50. Nonmedicinal ingredients: lactose, magnesium stearate, potato starch, povidone and sucrose. Store between 15 and 25°C, protected from light. Keep dry and dispense in glass.
ALKERAN® Glaxo Wellcome Melphalan Antineoplastic
Posted by RxMed

domain: literature


text:
Otter Ferry, the pioneering fish farming company, has been recognized by the Fish Farmer magazine for their innovative research and commercial operations. In a recent feature, the magazine highlighted Otter Ferry’s commitment to data collection and how they use aquaManager, an application developed by our company, to gather and analyse important information about their fish farm.
According to the article, aquaManager is a vital tool that helps Otter Ferry monitor everything from fish mortality rates to the stock levels of rotifers, which are a key indicator of how well the farm is performing. The application uses tablets to collect data from staff, which is then displayed on a dashboard that provides real-time insights into the farm’s operations.
“We’re thrilled to see Otter Ferry using aquaManager to enhance their operations,” said Kostas Seferis, founder of aquaManager. “Their commitment to data-driven decision making is truly inspiring and we’re proud to be a part of their success.”
“Our partnership with aquaManager has been instrumental in helping us improve our analysis and decision-making capabilities to build a more efficient and sustainable business. We look forward to continuing to work together for years to come.”José Vitor Barbosa, Operation Health Manager.
Otter Ferry has been at the forefront of the fish farming industry for years, thanks in large part to their innovative approach to research and commercial operations. With the help of aquaManager, they are able to collect and analyse data more efficiently than ever before, making it easier to optimise their operations and ensure the health and wellbeing of their fish.
Overall, the recognition of Otter Ferry by the Fish Farmer magazine and their use of aquaManager underscores the importance of data collection and analysis in the fish farming industry. With innovative tools like aquaManager, producers can optimise their operations and ensure the health and wellbeing of their fish, leading to greater success and recognition in the industry.

domain: agronomy


Water Flow Switch For Refrigeration Hvac R Parts - Chinaprice: contact company for price
that are used in liquid lines carrying water, ethylene glycol, or other
liquid not classified as hazardous. They can be wired to energize one
device or powered from the same source when liquid flow either exceeds
or drops below the set flow rate.
The rate of the flow can be adjustable and it is stable
Liquid temperature range: 0oC - +120 oC
Max. Working Pressure: 13.5bar
Note: The flow switch can't be used where the liquid in the pipes will drop below the liquid's freezing point, causing an internal freeze-up.
The flow switch include the size from 1/2', 3/4', 1'.
For more details please kindly contact with us.
- Posted By: Kanpus Refrigeration Co., Limited
- Phone: 008621660641984
- Address: Zhuanxin Road, Minghan District, Shanghai, China
- Website: http://www.kanpus.com
Published date: October 14, 2013 -
- Business Description: Kanpus Refrigeration Co. Limited is a professional manufacturer and
exporter in the field of HVAC industry, specializing in the
refrigeration and air conditioning system s products and refrigerator
spare parts. The main products include the condenser (condenser unit),
air cooler, compressor, copper tubes, filter drier, fan motor,
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Kanpus has considerable knowledge of all aspects of export including export documentation, regulations and procedures, added to our international trade experience ensures we have all the necessary skills to guarantee total customer satisfaction.
Our function is to provide a high quality, low cost, prompt and professional service to all partners and customers, 24 hours a day, 7 days a week. Adhering to the principles of "Selling Bigger Quantity with Lower Profit", we hope to cooperate with all partners for mutual success.
4 Way Reversing Valve For Refrigeration And Air Conditioner Hvac R PartsEquipment - Refrigeration - Kanpus Refrigeration Co., Limited - China - October 14, 2013 - contact company for price
DSF 4-way Reversing Valve is the component to provide heating and cooling from the system to the conditioned space by reversing the flowing direction of refrigerant, which is used at room air conditioners, packaged and central air conditioners. Our r...
Refrigeration Sight Glass Moisture Indicator Hvac R PartsEquipment - Refrigeration - Kanpus Refrigeration Co., Limited - China - October 14, 2013 - contact company for price
sight glass(moisture indicator) is a kind of element which shows the moisture and the flow of refrigerant. Descriptions 1. The content of refrigerant in the line of the system; 2. The content of water in the refrigerant; 3. Indicates the oil level of...
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Pressure controller can protect compressor and other part of the condensing unit if the system pressure is too high or too low. used extensively in the Air condition & Refrigeration industry. We make single and dual types. OEMs is available! All the ...
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text:
Tim McGraw's highly anticipated new album "Two Lanes of Freedom" drops Feb. 5. This time, he tells People magazine, it's "not a culmination of the things I've done, it's a new beginning of the things I am going to do." In an interview with the magazine, McGraw opens up about cleaning up his act, why he quit drinking, and whom he's doing it all for (hint: his three young girls).
"I drank a lot from my point of view and I needed to stop," McGraw, 45, told People mag. "I felt quitting was something I needed to do. I didn't feel I had any moral high ground with my kids in the long run."
"I'm in a good place right now," McGraw said, days before his new album comes out. "I have a busy life, but it is a fulfilling life."
People magazine, which hits stands this Friday, features the country star shirtless and showing off his eight-pack abs -- the result of the "weight-training and intense workout regimen" he's been doing for the past five years.
McGraw also talked to ABC News about "Two Lanes of Freedom," and said "[the album's title is] sort of about acceleration and looking out at the open road. I think, looking sort of metaphorically at my career, it looks like I’ve got a lot more ahead of me than behind me and that’s what I really feel like."
As for his dream duet partner -- Faith Hill not included -- McGraw told ABC News he'd love to sing with Bruce Springsteen.
Catch the Grammy Award-winning singer's performance on "Good Morning America" this Friday.

domain: celebrity


text:
A petition has been re-submitted on behalf of Malibu to break away from Santa Monica’s school district. There are class and racial equity concerns that the proposed school split could lead to a bifurcation between a very White and better funded Malibu district, and a more diverse and potentially less funded Santa Monica district.
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domain: news


text:
“MY-FOLIO represents you as a person, a designer or a brand before a page is turned”.
MY-FOLIO was founded by designer Lauren Grace, in response to her struggle finding a portfolio that did her work justice.
Graduating with first class honours in Fashion Marketing and working for numerous luxury brands such as Harvey Nichols and Fleur of England, Lauren wished to use her experience to create an innovative brand.
With a flair for creativity, an eye for perfection and a guilty pleasure for stationery and organisation, MY-FOLIO was born.
MY-FOLIO is your one stop shop to the most exclusive, CUSTOM presentation books.
MY-FOLIO is an online portfolio store dedicated to offering exquisite collections of personalised leather, Perspex & Bamboo presentation portfolios.
We know how hard you work to produce the contents of your folio so MY-FOLIO makes creating your personalised presentation book simple. Hand-picking only the highest quality British leather, whilst designing and producing each product entirely in the UK, ensures that each folio is a product you can forever treasure.
Each folio is designed to evolve and develop, as pages can be effortlessly refreshed using our screwpost and ringbound designs.
So, whether you're a new graduate wanting to get your work noticed, a business in need of branded materials, or newly-weds looking for a special way to display your memorable day, we can cater to your needs and provide the perfect presentation solution.

domain: design


text:
ProSep was awarded under a Joint Industry Project (JIP) agreement with Total, StatoilHydro and ConocoPhillips, a $1.4 million (CAD) contract for the final stage of development of the ProDry, a proprietary and innovative gas dehydration technology.
"Norway is the epicenter for research, development and commercialization of pioneering technologies for the global oil and gas industry," said Jacques L. Drouin, President and CEO of ProSep Inc. "Our joint industry partnership with super major oil and gas companies is a highly efficient collaboration model. It allows us to develop our pioneering technologies by addressing all project financing needs and rapidly validates market interest before our applications reach commercialization."
Under the terms of the agreement, ProSep will receive a total of 7.5 million NOK (approximately $1.4 million CAD) for the duration of the project, expected to be concluded in the second quarter of 2010. The Company will retain all property rights including technology, patents and licensing fees relating to future sales. Industry funding marks the third and final stage of the development of the ProDry now targeting pilot testing at high pressure, natural gas at Total's Lussagnet site in France.
The ProDry is a compact, light weight technology that efficiently mixes glycol into gas for dehydration. The ProDry utilizes ProSep's proprietary mixing and injection technology developed at the Company's Norwegian operations and provides a more compact and robust gas dehydration as compared to conventional technologies such as absorption towers. Compact and lightweight solutions such as the ProDry are increasingly being developed to address the needs of the growing offshore and subsea oil and gas production activities.
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Gaza Fixer: A chronicle of survival
Sumi Khan, Ben Piven, Jeremy Swinarton | 15 Jul 2013 10:54 GMT | Politics, Bangladesh
Source: Al Jazeera
Homes and places of worship targeted as violence sweeps country in aftermath of controversial war crimes verdicts.
Politics, Bangladesh, India, Pakistan
Schools and businesses shut as deadly clashes continue despite heavy security deployment.
Politics, Asia, Bangladesh, Pakistan
Wife of Raif Badawi, a blogger sentenced to 10 years in Saudi Arabia and 1,000 lashes, says he is a "peaceful person".
Human Rights, Politics, Saudi Arabia
Salman, defence minister since 2011, takes the throne at age of 79 after demise of his half-brother King Abdullah.
Politics, Middle East, Saudi Arabia
As the world's elite gather at the World Economic Forum in Davos, many Paris citizens struggling just to get by.
Main opposition Syriza party's platform of delaying debt repayment aims to sweep vote and undo austerity hardship.
Politics, Germany, Greece
The System examines two cases where prosecutorial misconduct may have led to wrongful imprisonment.
Crime, Law, United States
The FIFA presidential candidate explains why he is challenging Sepp Blatter and how he plans to reform the organisation.
Sport, Middle East, FIFA
The music of the Algerian Sahara, known as Ahalil, is a key part of a way of life that has survived for centuries.
Arts & Culture, Algeria, Music
People & Power investigates how a match-fixer and his syndicate corrupted global football.
Sport, Football, Corruption


text:
Sometimes, I bring my computer into the kitchen. I put it on a chair that I also use as a step-stool, because even on my tippy-toes, five feet four inches (plus a very important half inch!) is not enough to reach the top shelf. The chair is mostly used, though, to balance my laptop. So many recipes come from the computer these days. There's obviously Epicurious. And also Orangette (speaking of, it was so exciting to meet Molly at her book-signing at the Ferry Building last night!). And over the years, my mom has typed up a treasure trove of family recipes (organized in a somewhat byzantine fashion with a major bias toward dessert).
Often, while the computer is in place, the chair is also used to hold Jackson, one of our cats. He thinks that by sitting on the keyboard and accidentally scrolling up or down in a recipe, he's helping.
He really likes being in the kitchen. He (mostly) knows that the counter is off limits, but roams freely through the rest of the space, sitting on the chair as above or occasionally batting at the hanging dried chiles from New Mexico. Jackson enjoys being near me while I'm in the kitchen, but he is also extremely interested in human food. Human food with the exception of anything citrus, that is, which makes him wrinkle his nose in disdain.
His brother Jasper is the fatter of the two but only, and I mean only, likes kibbles. Here's a skinny picture of him at his grandparents' house. Trust me, he has quite a belly in real life. At his annual check-up last December, he clocked in at thirteen (yes, thirteen!) pounds.
Jasper comes in and out while I'm cooking to check on the progress. I enjoy my two not-very-helpful kitchen companions, but my college roommate JB has a toddler-sized helper who is particularly enthralled by making pasta.
As JB has learned over the years she's known me, pasta is one of many food items that is often purchased at the store, but can also be made at home. While some families grew up with Bisquick and Campbell's, my mom's cooking, even on--believe it or not--camping trips, was very "from scratch." (Not coincidentally, "from scratch" is a phrase B used to describe me the first time I made French toast for him.) It was important to my mom to make things that other people bought at the grocery. The difference, to me, is that tortillas and crackers and marshmallows all CAN be made at home, but egg pasta is something that SHOULD be made at home (at least for special occasions).
Pasta-making is an impressive tool to store in your armamentarium. When completely fresh, egg noodles add a soft yet substantial texture to a celebratory pasta dish. Frozen, the noodles will stay for months, ready to jazz up any pasta dish in minutes! The ingredients are simple and logical, and the proportions of my Italian great-grandmother's pasta dough are tried and true. Getting the balance between flour and water right takes a little practice, but it is never to late to learn.
Most pasta dishes taste better with fresh egg noodles. Try the noodles tossed with a little bit of butter and Parm and basil pesto for an easy weeknight meal. Or, try the Pasta with Bagna Cauda I'm including below, which is a vegetarian adaptation of the cover recipe from Nancy Silverton's A Twist of the Wrist. The book has been critiqued for having hard-to-find ingredients, and some of the recipes aren't as quick as promised, but the cover recipe alone is worth the cost of the book.
I use capers instead of anchovies, and less butter, but keep the egg and the Parm and the wilted radicchio unchanged. Bagna cauda means "warm bath," per Nancy, and it is a luxurious sauce. Another recipe for the carbo kid, I guess.
Or a recipe for JB, now that she has a kitchen helper and knows the power of what can be made at home. Enjoy!
Egg Noodles (a.k.a. "Noo-noos" in toddlerspeak)
Makes approximately 1 lb pasta
Time: 30 min. active, 45 min. total
5/8 cup water
2 T. olive oil
1 c. semolina flour
2-3 c. all-purpose flour
Mix eggs, water, olive oil, salt, semolina and 1 cup regular flour together in a large bowl with a wooden spoon. Continue adding flour 1/4 cup at a time until dough pulls away from sides of bowl and has a firm, not sticky, consistency. Let stand for 15 minutes before rolling out with pasta machine, ending with the second-thinnest setting. Use plenty of flour throughout! I use a hand-crank pasta machine, but JB uses the Kitchen-aid attachment. Run sheets of pasta through the fettuccine attachment to make noodles each about 10 inches long.
Pasta with Bagna Cauda
Adapted from Nancy Silverton's A Twist of the Wrist
Serves: 4 for main course, with leftovers
Time: 30 min active and total
1 lb. egg noodles
1/2 stick unsalted butter
1/4 c. plus 2 T. olive oil
1 T. capers
8 garlic cloves, smashed
1/4 c. finely chopped fresh Italian parsley leaves
grated zest and juice of 1/2 lemon
4 large eggs
12 radicchio leaves, torn into pieces
Parmesan, for grating
Bring a large pot of water to a boil over high heat and add a generous amount of kosher salt. Cook the fresh pasta for 4-5 min, depending on the thickness of your noodles, or until pasta starts to float. If in doubt, taste the pasta for doneness.
While the water is coming to a boil, make the bagna cauda. Heat the butter, 1/4 c. olive oil, capers, and garlic in a large skillet over medium-high heat until the garlic is soft and fragrant, about 2 minutes, stirring constantly so the garlic doesn’t brown. Turn off the heat, then stir in the parsley and lemon zest and juice. Season with salt and pepper to taste.
Heat the remaining 2 T. olive oil in a nonstick skillet over high heat for 2 to 3 minutes, until the oil is almost smoking. Break each egg and cook for about 1 1/2 min, until the edges are golden and crispy and the whites are set. Turn off the heat.
Use tongs to lift the pasta out of the water and transfer it quickly, while it’s still dripping with water, to the skillet with the bagna cauda. Place the skillet over high heat and add the radicchio. Toss to combine the ingredients and cook for a minute or two, until the radicchio wilts.
Serve pasta onto plates. Grate a generous layer of Parmesan cheese over each serving. Place one egg on each serving of pasta.


text:
Football: SADLIER DUMPS BAGGIES; West Brom 0 Millwall 2.
Dublin-born Sadlier doubled his goal tally for the campaign as he found the target in the 19th and 26th minutes to sink high-flying Albion.
Sadlier struck for the first time when he collected a fine pass from defender Sean Dyche with the Albion defence caught napping.
Sadlier then brilliantly turned Icelandic defender Larus Sigurdsson before lashing a fierce right-footer into the back of the net.
Mark McGhee's Millwall increased their lead seven minutes later - and Sadlier was again the marksman.
Des Lyttle made a hash of his backpass and Steve Claridge pounced to charge into the area.
The striker then crossed to midfielder David Livermore, who fired in a hard shot from the edge of the box.
GLENAVON have released goalkeeper, John Connolly from his contract only two months into the new season.
Connolly, who kept goal for Derry City last season, has moved to eircom League First Division leaders, Finn Harps to ease the club's goalkeeping crisis.
SADLIER: Super double
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|Publication:||The Mirror (London, England)|
|Date:||Oct 12, 2001|
|Previous Article:||Football: HUGHES A CLEVER BOY THEN, JAMIE; Derry C 1 Bohemians 0.|
|Next Article:||Football: Was this the greatest double save of all time?|

domain: sports


A recent outbreak of bicycle thefts across campus prompted an email from Campus Safety notifying students and urging those with bikes on campus to use caution.
Justin Revel ‘19 is one of the students who had their bike stolen in the past few weeks. Revel explained that he lives in a MILE house and uses his bike daily to get to campus.
Revel’s bike was stolen from where he kept it locked up behind the house while he was at baseball practice.
“I contacted Campus Safety and met with them to describe my bike and the situation. Then I contacted Allentown Police Department but I never heard anything back,” Revel said.
“I had a blue Schwinn mountain bike. I typically keep a standard four letter password combination lock,” Revel said of the bike that was stolen. He has since replaced it, although he is using the same style lock as before.
One of Revel’s housemates, Seth Wasserman ‘19, also uses a bike as his main mode of transportation. “It’s like my only way to get to campus anymore,” Wasserman explained.
The recent rise in thefts have made Wasserman concerned that he might have his bike stolen as well.
“From what I’ve heard, even the ones that were locked up, they cut the lock. If they want my bike, they’re going to get it, nothing I can do about it besides locking it up,” Wasserman said, adding that Revel’s bike was taken from their backyard.
While Wasserman doubts the thieves will take his bike “during broad daylight,” he does feel nervous about leaving it out at night. He mentioned an instance where he needed to go into the Life Sports Center for an errand and debated locking up his bike even though “it wasn’t worth going through the hassle for the 30 seconds” he would be inside for. Yet there was still the thought that in those 30 seconds, Wasserman’s bike might be gone.
“As far as trying to prevent a bicycle theft, always try to secure the frame of the bicycle to a fixed object using a U-type steel lock,” Campus Safety Officer James Thamarus said. He added that the cable locks that appeal to students thanks to their price are to be avoided as they can easily be cut.
Both Revel and Wasserman mentioned that they did not know about registering their bikes through Campus Safety, something that Thamarus urges all students with bikes on campus to do.
When registering bikes, either Thamarus or Officer Kevin Kennedy will take the student’s name and contact information, a description of the bike and the serial number. Bikes are then given a Muhlenberg College Bicycle Registration decal. Registering bikes is similar to applying for a parking pass, keeping accurate records of the vehicles on campus should anything happen. The registration process is both free and fast and can be done from 7:00 a.m. to 3:00 p.m. seven days a week.
“If the bike is ever stolen and found, Campus Safety will be able to run the registration decal to identify the owner of the bike, so that it can be returned to the owner,” Thamarus said. “The same thing would happen if the bike were to be found by the Allentown Police Department. The Allentown Police would see the Muhlenberg College bicycle registration and be able to contact Campus Safety to identify the owner.”
While registering the bike, Thamarus mentioned that they also give the bike a tune-up, doing minor repairs and adjustments. Both Kennedy and Thamarus attended a bicycle repair technician school a few years ago and are able to offer repairs after the initial registration.
“Usually, if a student has his or her bike at Muhlenberg College and it’s in need of a repair, the bike will have to sit until the student can take it to a bike shop,” Thamarus said. “We use that training as a way to get involved with the campus community by offering free bicycle tune-ups and repairs if needed.”


text:
WASHINGTON (AP) - Andrei Loktionov scored the tiebreaking goal at 3:36 of the third period, and the Los Angeles Kings beat the punchless Washington Capitals 4-1 Saturday to extend their point streak to a season-high eight games.
Michal Handzus and Jarret Stoll also scored in the third period for the Kings, whose 6-0-2 run is their longest since a nine-game streak from Jan. 21-Feb. 6, 2010.
Los Angeles is 3-0-2 at the midpoint of a franchise-record, 10-game road trip.
Jonathan Bernier had 22 saves for the Kings after allowing a goal to Alex Ovechkin on the first shot of the game. Bernier, the backup to Jonathan Quick, has not yielded more than two goals in four starts.
The Capitals have scored two goals or fewer in nine of 13 games. Semyon Varlamov made 24 saves for Washington, which will play its next five games on the road.
EDMONTON, Alberta (AP) - Alex Kovalev had two goals and an assist for Ottawa, which snapped an 11-game losing streak and avoided falling into the NHL basement by beating last-place Edmonton.
Milan Michalek, Bobby Butler and Peter Regin also scored for the Senators (18-30-8), who broke an 0-9-2 skid and moved four points ahead of Edmonton. Brian Elliott needed to stop only 15 shots to earn the win.
Dustin Penner had a pair of goals, and Andrew Cogliano netted the other for the Oilers (16-31-8), who have dropped two in a row and have won only two of 13 games. Nikolai Khabibulin made 20 saves, but his personal losing streak was extended to 14 games.

domain: game


text:
November 18, 2021
Gamechanger – Nick Nadal
Corporate Governance & Sustainable Finance Expert
When talking about accomplishments, Nick Nadal will not run out of things to share. But he is a man who would rather not discuss himself. A conversation with him will just be about the causes he’s involved with and how this can benefit many.
A corporate expert who works for the government of Dubai, specifically the Dubai Sustainable Finance Working Group, he is one of the key persons behind making the emirate a global player in sustainable finance. He does this while working on advancing good governance practices in regional organizations, addressing boards and decision-makers, framing decisions related to environmental responsibility, fairness to labor and community, company stewardship, and relationship to society, among others. He also has set-up a regional think tank on corporate governance driving research, company engagements, and program development.
With all that he has learned through the years serving various causes, Nick encourages Filipinos to elevate themselves by embracing the greater community that they belong in. “We need to realize that human dignity, environmental responsibility, and the general need to be kind transcend our communities, and that despite differences in geographies, in how each one of us were raised, in our education, and in our general outlook in life, all of us have much more in common than there are differences. So, let’s all work to elevate the place we live, work, and play, by so doing, we also elevate our communities and ourselves.”
Advisor at the Executive Council, Government of Dubai
Photo by Alex Callueng; Photography Assistant – Bethoven Filomeno
Most often in modern society, those who deserve recognition are the ones who desire it the least. Such is the case with the elusive Nick Nadal – a corporate governance and policy-making powerhouse who, in his capacity as Advisor at the Executive Council of the Government of Dubai, is quite possibly the most influential Filipino in the UAE outside of public office.
Nick’s work is so important, most of it is unprintable – which is no skin off of his nose, as he is always very hesitant to participate in any conversation about his immense achievements in the region. That’s just how Nick rolls: he gets the job done, and then he lets the results speak for themselves. And what amazing things this man has been ticking off his to-do list. Case in point: he is part of the core team that helped develop, articulate, cascade, and implement arguably one of the UAE’s more consequential government plans, particularly in the area of government services improvement and innovation, urban governance, and affordable housing. Through a corporate governance institute that he helped set up in the UAE a decade ago, he spearheaded the enhancements of a number of initiatives related to advocating for greater gender diversity in the workplace, thereby helping put more women in positions of top management decision-making and innovation-enabling.
But perhaps what’s really impressive about Nick is how he manages to remain resolutely grounded and centered despite his sky-high list of accomplishments and frenetic whirlwind of responsibilities. In lieu of his many triumphs in the corporate and government sector, he would much rather talk about the fancy raclette that he whips out during dinner parties at home, or how he – above and beyond being one of the most influential Filipinos in the Gulf – is first and foremost a loving son, a loyal friend, and a dutiful husband.
Special thanks to Illustrado 100 Most Influential Filipinos in the Gulf 2016 sponsors – Giordano, Nikon, Liali Jewellery, Lulu, Mitsubishi and Western Union.
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text:
Southwest Design & Construction
- 3755 - 18 Ave North Lethbridge AB T1H 6T2
- (403) 320-5400
- (877) 414-4043
- (403) 329-3387
- Send Email
From Crowsnest Highway, turn down 43st N and go to end of road. Turn left on 18 Ave and drive past rail road track. Shop is on the right.
Southwest Design & Construction have over 40 years of experience in the Canadian construction industry. We service the AB, SK, MB, BC, NT and YT. Call us for your quote!

domain: geography


text:
An immunotherapy combining an approved and an investigative treatment — Imfinzi (durvalumab) and tremelimumab — showed potential to reduce tumor activity and prolong survival as a second-line therapy in patients with metastatic urothelial cancer, a common type of bladder cancer, according to data from an open-label Phase 1 study.
The combined treatment resulted in an objective response rate of 20.8 percent, or 35 of the 168 advanced cancer patients, with responses being durable (lasting between 1.9 and 24.9 months) and early — a median of 1.8 months after a first treatment — according to results reported at the recent American Association for Cancer Research (AACR) annual meeting.
Data from this Phase 1 trial (NCT02261220) were presented in the poster, “Durvalumab + tremelimumab in patients with metastatic urothelial cancer.” Analysis was conducted on results collected through Oct. 20, 2017, with a median follow-up of 11.6 months.
At six months, the progression-free survival (PFS) rate was 25.4 percent with a median PFS of 1.9 months, and the overall survival rate was 60.9 percent, with a median of 9.5 months.
Durvalumab, sold under the brand name Imfinzi, is a human antibody that specifically binds to PD-L1, impeding its interaction with PD-1 and CD80, two molecules that cancer uses to evade an immune system attack.
Imfinzi is approved by the U.S. Food and Drug Administration as a second-line therapy to treat platinum-chemotherapy resistant metastatic urothelial cancer, a cancer of the urinary system. It is also approved for certain advanced non-small cell lung cancer patients, and is under investigation in other cancers.
Tremelimumab is an investigational human antibody that blocks the activity of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). As such, it helps to activate T-cells, immune system cells with cancer-fighting abilities.
In this Phase 1 trial, patients with platinum-refractory metastatic urothelial cancer received Imfinzi at 20 mg per kilogram of body weight and tremelimumab at 1 mg/kg of body weight for four months, followed by 10 mg/kg of Imfinzi for 12 months.
Enrolled urothelial cancer patients — the trial involved 380 patients with various advanced solid cancers — were divided into three groups: those with PD-L1 expression — and subsequent T-cell suppression — equal or higher than 25 percent (68 patients), those whose PD-L1 expression was less than 25 percent (86 patients), and 14 other patients whose PD-L1 expression was not known. Overexpression of PD-L1 is associated with poorer outcomes.
Overall, treatment was seen to be safe and effective in reducing tumor activity regardless of a person’s PD-L1 status. But those with the highest expression rates — PD-L1 higher than 25 percent — had higher response rates (29.4 percent vs. 15.1 percent) and superior six-month overall survival rates than those with PD-L1 expression levels lower than 25 percent.
The most common treatment-related adverse effects were severe itching, or pruritus (26 percent), fatigue (24 percent), diarrhea (20 percent), rash (14 percent), and higher-than-usual levels of lipase (12 percent), an enzyme that at high levels can be a sign of pancreas damage. One patient died of a pulmonary hemorrhage that was found to be treatment-related.
Trial results in people with advanced non-small cell lung cancer were also reported at the AACR meeting.
“The mature data sets from these Phase I trials help further characterize the overall survival of durvalumab plus tremelimumab combination in 2nd-line nonsquamous nonsmall cell lung cancer and 2nd-line metastatic urothelial carcinoma,” said Sean Bohen, chief medical officer for AstraZeneca, in a press release. “We look forward to exploring whether OS is distinguished from durvalumab monotherapy in our Phase III MYSTIC and DANUBE trials, expected to read out later this year and next year, respectively.”
Imfinzi in combination with tremelimumab, or Imfinzi alone, are being tested against standard-of-care chemotherapy as first-line therapies in non-small cell lung cancer patients in the MYSTIC (NCT02453282) study, and in advanced urothelial cancer patients in DANUBE (NCT02516241).

domain: biology


text:
New and expanded edition of Duellman's classic work, first published in 1970 and long out-of-print. Since 1970, the number of species has risen by 50 to 165, most of them new species from southern Mexico, Guatemala, and Honduras, and all them from the highland regions. This greatly enlarged edition (a 55% enlargement of the original, plus 20 new plates) includes not only the original text but also a supplement in which each species account is revised and new or resurrected species are treated in detail. Species accounts are arranged as in the original edition: synonymy, diagnosis, description, tadpoles, mating call, natural history, remarks, etymology, and distribution.
Review of the first edition:
"In tropical American herpetology, it is likely to remain an unassailable model. It marks an apogee of achievement; it is the Hope Diamond of technical herpetological literature."
– Herpetological Review


I go through phases. Somedays I feel like the person I’m supposed to be, and then somedays, I turn into no one at all. There is both me and my silhouette. I hope that on the days you find me and all I am are darkened lines, you still are willing to be near me.
"Horsemanning, or fake beheading, was a popular way to pose in a photograph in the 1920’s. Sometimes spelled horsemaning, the horsemanning photo fad derives its name from the Headless Horseman, a character from “The Legend of Sleepy Hollow.”
“While newspapers and television talk about the lives of celebrities, the chief of the Kayapo tribe received the worst news of his life: Dilma, “The new president of Brazil, has given approval to build a huge hydroelectric plant (the third largest in the world). It is the death sentence for all the people near the river because the dam will flood 400,000 hectares of forest. More than 40,000 Indians will have to find another place to live. The natural habitat destruction, deforestation and the disappearance of many species is a fact.” What moves me in my very bowels , making me ashamed of being part of Western culture, is the reaction of the chief of the Kayapo community when he learned of the decision—his gesture of dignity and helplessness before the advance of capitalist progress, modern predatory civilization that does not respect the differences …
But we know that a picture is worth a thousand words, showing the reality of the true price of our bourgeois “quality of life”.


text:
Sharks: Predators of the Sea reveals the true nature of these remarkable prehistoric creatures. As an apex predator in their watery world, they are critical to the health of the world's oceans but also largely misunderstood. This book is the perfect choice to engage readers and shed light on this important marine animal.
The book is packed with 200 full color photographs plus sidebars, fact files, and illustrations. Chapters of accessible text describe the natural history of 17 of the world's 450 species of sharks along with some shark relatives. Special features on shark biology describe the physical characteristics that make them so remarkable.
Sharks: Predators of the Sea covers these 17 shark species: Great White, Great Hammerhead, Bull, Mako, Blue, Thresher, Tiger, Lemon Shark, Goblin, Wobbegong, Dwarf Lanternshark, Cookie-cutter, Greenland, Whale, Megamouth, Frilled, and Reef,
plus a few shark relatives, the Manta Ray, Stingray, Electric Ray, and Sawfish.
|Publisher:||Firefly Books, Limited|
|Product dimensions:||8.60(w) x 11.40(h) x 0.40(d)|
|Age Range:||9 - 12 Years|
About the Author
Anna Claybourne is an award-winning children's author based in Edinburgh. She has written more than 100 books, and specializes in life science topics.
Most Helpful Customer Reviews
The images are very nice and not scary, for those who may be afraid of sharks. However, just learning about the few you have in the oceans where you live might be scary enough to make you want to never swim again! I know my moms totally afraid of sharks, someone who goes to the beach often or use too! However, with all the shark attacks, it sort of made her scared to ever go to the ocean and I wouldn't blame her. Especially, watching movies with sharks, how big and scary that would be to lose someone. Well, this book covers so many sharks and honestly I rather just read about them and not have to see them in the water! Finally, this is a terrific guide and a wonderful book for both adults and children!


text:
Estate planning is crucial as it ensures that a person’s assets will be distributed at the time of his or her death in accordance with the person’s particular wishes.
Erin Searcy Law is willing to work closely with you to either update your existing plan, or to develop a customized plan which addresses your circumstances.
A will is an individualized, commonly utilized estate planning document which sets forth the creator’s specific wishes concerning how he or she wants for assets to be distributed upon the creator’s death, and who will be responsible for the distribution. A will is the simplest way to establish an estate plan, and it is given no legal effect until the person passes. A court process, known as a probate proceeding, is necessary in order to give the will effect.
A trust is an artificial entity created by a person, known as the settlor, in which a trustee is designated to manage and use property which has been put into the trust. In the trust instrument, the settlor can designate specific beneficiaries to whom he or she wants for the trust assets to be disbursed. There are many different types of trusts which are utilized for varying reasons, and the pros and cons of each should be considered in light of the person’s specific circumstances.

domain: finance


text:
Railroad St, Felsenthal, AR 71747, USA
Rare corner lot located in the community of Fensenthal near the Ouachita River.
Please Note: Approximate boundary lines are shown based on the metes and bounds legal description.
Property Address: 0 Railroad Street, Fensenthal, AR 71747 (Map location is approximate)
Assessor Parcel Number: 00000-09348-0015
Legal Description: Commencing at the Southeast corner of Block 156 of the Original map of Felsenthal; thence South 89 degrees 50′ East along the North right-of-way line of the St. Louis Iron Mountain and Southern Railroad (abandoned) 443.77 feet; thence South 49 degrees 26′ 30″ West 2.68 feet for a point of beginning; thence continue South 49 degrees 26′ 30″ West 122.24 feet; thence North 71 degrees 26′ 37″ West 28.79 feet; thence North 23 degrees 12′ 29″ East 107.76 feet; thence South 69 degrees 42′ 53″ East 82.84 feet back to the point of beginning, containing 0.14 acres of land, more or less.
Annual Property Taxes: $31.00Purchase ID : 51010
Owning a home is a keystone of wealth… both financial affluence and emotional security.Suze Orman


Fill out the form below to submit a maintenance request for your Dishwasher
Preferred Contact Method:
1. Does it have water coming in it when the dishwasher's turned on?
2. Does the water drain out of the dishwasher?
3. Does the dishwasher turn on at all?
> If not, did you check the breaker?
4. Is water leaking onto the floor from the dishwasher?
> Around doors or under dishwasher?
Please Specify The Problem:
TEL. (479) 524-4060


text:
San Francisco-based fine jewelry brand Cast is excited to welcome neighbouring Bay Area designer Lauren Harwell Godfrey as their latest guest designer to create an exclusive collection for Cast to add to their growing roster of all-female collaborators. Godfrey’s collection, titled “Spellbound” is a celebration of cool and collected California style featuring natural turquoise in hex-shaped stacks, 14K gold, diamonds and blue zircon.
The Collection launch supports Cast’s mission to bring more discovery, wonder and joy to the fine jewelry shopping experience.
Co-founder and Chief Creative Officer Rachel Skelly partners with a variety of designers to craft and curate exclusive collections. Every artful piece is distinct yet each can be paired together for layered and unexpected looks. With her unique partnership approach, Skelly has crafted a remarkable global roster of some of the most innovative designers in the jewelry business including Alice Ciccolini, Francesca Villa, Kristy Ford, Stacy Nolan and now Lauren Harwell Godfrey.
“Working with Cast was a collaborative experience that required trust and a lot of care. Rachel has a great love for innovative, eye-catching fine jewelry and I knew that my designs would be in good hands with her and the entire Cast team,” says Godfrey. Godfrey’s Spellbound Collection captures her signature style using gemstones and figurative references from cultures long ago.
Skelly explains, “It’s been a thrill to work with Lauren on this collection. Given my roots in graphic design, I’ve always been so drawn to Lauren’s striking graphic style. Her aptitude for design along with her use of bold gemstones, colour and geometric patterns drew me in and I knew immediately that I wanted to work with her. It’s been an honour working beside her to bring to life this special collection that is infused with the rich symbolism that is so signature to her style.”
The Spellbound collection celebrates the power of turquoise, known for its ability to captivate and calm. The true beauty lies in the combination of raw meets refined. The natural matrix marbling of this powerful stone stacked against rich 14K reclaimed gold and a radiating pattern of Canadian pavé diamonds create a striking balance. Keeping to the calming blue tones, blue zircon brings an added sparkle and the bold hex shapes bring a graphic structure to the design that is synonymous with Godfrey’s own collection.
Explore the world of Canadian Jeweller Magazine, your one-stop shop for the latest trends, news and insights into the Canadian jewellery industry. Discover stunning collections, expert advice and exclusive interviews with top designers and artisans.

domain: artistic


Disturbed frontman David Draiman has enlisted a number of rock luminaries to perform on the debut album of his side project, Device , with former Filter guitarist Geno Lenardo .
Draiman posted a message on the band’s Facebook page on Friday, announcing that the upcoming release will include appearances by Avenged Sevenfold frontman M. Shadows , System of a Down singer Serj Tankian , Rage Against the Machine guitarist Tom Morello , Halestorm frontwoman Lzzy Hale , Black Sabbath bassist Geezer Butler and former Deep Purple bassist Glenn Hughes .
The singer also revealed that in addition to Lenardo, Device’s touring lineup will feature Evanescence drummer Will Hunt and Dope guitarist Virus .
Draiman noted that the album’s first single,“Vilify,” will arrive at radio on February 19. Other song titles that are expected to be a part of the release include "You Think You Know," "Recover," "Hunted" and "War of Lies."
While a title for the album has yet to be announced, it is expected to be released on April 9.
Copyright 2013 ABC News Radio


text:
Bankruptcy is a legal process aimed at the elimination of debts of individuals, businesses and families. If you or your corporation is facing financial distress, bankruptcy may be the best form of debt relief. For both individuals and corporations, bankruptcy offers a framework for resolving various types of debt. It can also provide rules for the determination of how the assets will be repaid. Laws of bankruptcy can also deter creditors from taking harassing collection actions against the debtor. At Barth Calderon LLP, our asset protection attorney can help you and your business take action to obtain debt relief!
If your business is struggling and you are in need of financial relief, bankruptcy may be the right option for you. Deciding when to file and which chapter to file under can be stressful, but with the assistance of an attorney from our team, you can be assured that your case will be in good hands. Your first step to find debt relief should be to call Barth Calderon LLP. As a business owner, you likely feel overwhelmed at the prospect of filing for bankruptcy, but we can provide the assistance you require. Our firm will answer all of your questions and do what we can to ensure that your assets are protected. During a free case evaluation, our legal team can discuss how bankruptcy can benefit your business.
As a debtor, you can use Chapter 11 of the bankruptcy code to reorganize the debts of your business. Under this chapter of bankruptcy, some significant business decisions may be made by the court, but the process can help make your debts more manageable. You can also file for Chapter 7 bankruptcy to help eliminate business-related debts. In this circumstance, a trustee will be appointed to liquidate all of the company’s assets and use the proceeds to repay creditors. If you are considering bankruptcy for your business, we encourage you to contact our trusted team. As your individual or corporate bankruptcy lawyers, we offer the counsel you need throughout each stage of this trying and stressful process. Contact us today for more information!

domain: law


To create videos that stand out of the crowd use The Movie Maker: The World's smallest camera motion control units.The Movie Maker is a 2 in 1, 9 speed Electronic Slider & Motorized 360° Panoramic Time Lapse Head. For Small Cameras up to 750g weight capacity, extra tracks are available. Converts into a micro dolly (sold separately).
May be used horizontally or vertically and either manual or electronic mode, runs 2 hour on internal rechargeable battery or USB powerpack for very long timelapse shots.
Convenient 1/4" mounting threads at bottom to use with tripod, suction cups for diagonal, vertical or inverted shots
Light weight, highly functional fits into a small bag.
Designed by Hollywood veterans with a passion for motion.
- 9-speed Electronic Camera Slider & 360° Panoramic head conversion
- Great for all cameras less than 1.7 lbs.
- Take awesome packaging and wedding videos, operates at any angle, even upside down
- Share sunsets, powered with a 2 hour internal rechargeable battery or use with USB powerpack
- Use in any location, 1/4" mounting threads attach to tripods, suction cups for diagonal, vertical or inverted shots
· Convenient ¼ inch threads under each track join to attach to any tripod, suction cups etc
· Comes with 2 x 31cm tracks, additional tracks are available for extensions
· Plug into a power bank operating times +36 hours (10400MA), or use internal rechargable battery for 2 hours
· Remote control for both speed and direction (9 speeds)
· Bounce back for continuous motion, can be turned off): When reaching end of track it will move in opposite direction
· Motor speeds vary from 4mm/minute to a 1000mm/minute
· Operates as eletronic or manual slider
· Can climb 90 degrees & can operate upside down
· Weighs 900g and can hold up to 750g phone/camera on vertical climb
Runs perfectly smoothBy: John on 30 November 2018Does what it's suppose to do. The motor runs perfectly smooth on the track. Wish panning feature is possible while running on track. But all in all, everything is perfect, good value for the money.
Love it.By: Anthony Yarde on 30 November 2018It’s awesome works like a charm. Although you can’t rotate and slide at the same time, I have an independent rotating time lapse unit I mount on top of the dolly to get both effects at the same time.
Quiet and powerful, this slider deliversBy: Scrittore on 30 November 2018Wow. Compared to other units priced hundreds of dollars higher, Grip Gear has nailed it with this beauty. Does exactly what I need: close-up document motion pans using the iPhone X's broadcast quality video cam. Don't try using a heavier DSLR, this wouldn't be up to the task. Lightweight for portability, solid build quality, absolutely silent in action, this Movie Maker 2 slider delivers.