Honda is looking to become the world’s first carmaker to mass produce Level 3 autonomous vehicles, as per Reuters. These cars will be capable of driving themselves in congested motorway traffic while legally allowing drivers to take their eyes off the road.
The Japanese government has already awarded Honda a safety certification for its ‘Traffic Jam Pilot’ system. The first model to feature this updated system will be the Legend, hitting the road in Japan sometime before the end of March, 2021.
“Self driving cars are expected to play a big role in helping reduce traffic accidents, provide transportation for the elderly and improve logistics,” said Japan’s Ministry of Land, Infrastructure, Transport and Tourism.
Read Also: Honda Joins FCA In EU Emissions Pooling Scheme With Tesla
In order for a car to meet key safety standards with regards to automated driving, the system must be able to “warn the driver of the transfer of control (handover) back to the driver and must continue safe driving until the handover is completed. When the handover cannot be made, the equipment must safely stop the vehicle.”
Other must-haves include the equipment featuring a driver monitoring function, as well as cyber security measures in order to prevent security threats such as unauthorized access.
Furthermore, a recording device must be present to “record data to confirm operating conditions of the automated driving equipment for a 6-month period (or 2,500 times)”.
Last but not least, Level 3 autonomous cars will require a sticker indicating that the vehicle features an automated drive system. This sticker “should be affixed on the backside of the vehicle body.”


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mixing alcohol with xanax
by janet shorden
(st albans wv 25177)
What can you say to bipolar manic depressed person when nothing makes them happy at the time. And i am afraid to say anything because he will go into a screaming rage. Then when i am quiet he ask me to talk to him. I feel my best bet is to be still. How do you entertain a manic bipolar person?
You can't entertain a manic person; and you can't allow him to hold you hostage under threat of verbal and emotional abuse just because he's Bipolar. It does take tremendous patience, love and determination to live with a person struggling with Bipolar Disorder, but you have to know what your limits are. There has to be some sort of healthy, sane dialog between you - some plan of action for when he's in a state of mania - so that you can remain safe and keep your own sanity and peace of mind.
A person with Bipolar Disorder has to become an expert on Bipolar Disorder, and an expert on how to cope with their own moods and live a healthy life, or they will always be in chaos and crisis. And anyone brave enough to be in a relationship with them has to do the same. And they need to have a way to talk about that. Otherwise you will get nowhere.
Therapy would be my first recommendation. If none is available, then at least read all the books you can get a hold of on BP and he needs to do the same.
I'm not sure why your title is "mixing alcohol with xanax" - but that is a very dangerous combination, and definitely wont improve anyone's life.
It really is possible to change things if you're both committed to working on it. But it takes two.
Ben Schwarcz, MFT
Santa Rosa Psychotherapist
NEW EFT/Meridian Tapping eBOOK!
Tapping Into Joy: Meridian Tapping and Mindfulness for Depression
With bonus Tap-Along Audio Book and Full-length Guided Meditation Audio
A 96-Page guide to lead you out of the darkness of depression and into the light of your own True Self.
Learn to use Meridian Tapping/EFT for your own self-healing from Depression, Anxiety, Trauma and Stress. Step by Step instructions from the basics to the subtle art of getting powerful results quickly, even with complex issues.
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Click here to post comments
Return to Ask a Therapist.

domain: psychology


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Next Generation AT3 All Terrain Pet Stroller is available in two fun colors, Blue Sky or Poppy Red. Your dog or cat will love riding with you wherever you go. It keeps your small pet safe in crowds, provides them with a new view and fresh air on your walk. Many small pets are unable to go the distance and at our pace during our exercise routines and with a stroller they can enjoy with you!
Front wheel fixed and swivels.
Easy one-hand fold.
12" E.V.A. Tires.
Front and rear entry
Parent tray with cup holder
Large Storage Basket.
Quick Lock Foot Break.
Rear Wheel Shock Absorbers.
Interior Safety Tether.
Top and front ventilation windows.
Interior Dimensions: 30.5"L x 14"W x 24"H or (77cm x 35cm x 61cm).
Available in Blue Sky and Poppy Red.
For Pets up to 60 lbs.
this item ships directly from the manufacturer in order to expedite
This policy has been implemented due to sanitary & hygienic reasons, and dogs' inherent tendencies to mark products that have the scent of another animal on them. You can be assured that all of your products are new & unused for your pet.
Due to strict health regulations, we cannot accept returns or exchanges on strollers. Please select carefully for your pet before purchasing.

domain: pet


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Several homes, businesses and vehicles belonging to members of Côte d’Ivoire’s Dioula ethnic group were randomly set ablaze in a new ethnic-based violence that rocked the country’s far west on Monday, April 1, 2019.
Ben-Hounien, a densely populated city in western Côte d’Ivoire, was engulfed in flames after a Yacouba motorbike rider ‘accidentally’ drove his bike into a parked truck belonging to a Dioula, sustaining severe head injuries. He eventually died of his injuries.
Striking back, young men of the Yacouba tribe, heavily armed with machetes, spilled out of buses into the town, fired up by a desire to fight, and to die if necessary. They launched random arson attacks on homes and stores, among other valuable properties belonging to the Dioulas: their perceived longstanding enemies.
The Ivoirian government must take concrete steps to end the growing tension between the Yacouba and Dioula communities of western Côte d’Ivoire. Dozens of people have been killed in repeated clashes between Yacouba and Dioula communities in this part of the country.
Monday’s attack comes only five months after a similar ethnic-based clash dramatically escalated in Zouan-Hounien, a busy trading hub in the far west of Côte d’Ivoire. That November 21, 2018 ethnic clash left several persons dead and a dozen others severely wounded.
The truth is that simmering tension between both communities still lingers, a major remnant of the country’s 2002 – 2007 civil war which claimed many lives on both sides. Also, a 2011 electoral violence that further rocked the cocoa-growing west African state left deeply embedded hateful scars on both sides.
Today, though the guns have fallen silent, intense ethnic and religious rivalries continue to cripple possibilities of social cohesion across western Ivory Coast.
These recurring clashes show the persistence of this problem and should be of great concern. The Ouattara government cannot continue to ignore this glaring and fast growing ethnic-based tension. An independent investigation into these clashes will be a great step towards ending the violence.
What to do after reading this article: leave a comment below, and please share it with your social networks

domain: news


TTPod 7.3.0 is the latest version with so many improvements. This app is the best music player with all the features, graphic and sounds. For the initial display, we’re treated to a folder to select the songs that we will play after splash screen. We only determine just by clicking on it. If it has not been scanned, then insert the folder first and scanned. Well this is the difference this app with some other applications that are already listing the automated and sometimes we are especially troublesome if the music file does not want to play.
The interface is simple with most of the music player icon. There are 3 tabs that will display song info will load in turn, and there are cooler again to display the lyrics. So when we play a song and if it is found then the lyrics will be displayed. Either download or lyrics from the lyrics of the SD Card. So TTPod is a music player support android lyrics. Not until there only when opening the menu it will be a lot of menu navigation to support this android music player. Such as skin, info, and do not miss and i rarely there is an android music player equalizer. In Equalizer, there have been several presets that can be selected.
Features of TTPod 7.3.0 APK
- Landscape mode
- The spectrum of the new interface with audio-visual effects.
- Menu button right.
- Lyrics page.
- The new recommendations
- Songs downloader.
What's New in TTPod 7.3.0 APK
- 5 star praise during the World Cup in everyday sounds # # where the user evaluation and bring a personal name Sina Weibo, one user sent every day to extract four T1 headset sounds a continuous delivery month.
- We will pass every day sounds official microblogging winning user and collect contact information such as contact address, five days after the event sent prizes.
The equalizer feature is my favorite. Besides that, I love the lyric and there isn’t app which gives you all in one.
Developer: TTPOD Size: 9 MB Version: 7.3.0 Requirement: Varies with device Price: Free


Obama Era Judge Shuts Down Trump’s Attempt To Open Fed Lands to Coal Mining
Andrew Harnik / AP
Obama instated the policy in 2016 as part of his administration’s environmental agenda to cut coal usage.
Morris’ decision states that former Interior Secretary Ryan Zinke did not consider the full environmental effects of overturning the coal mining ban and ordered the Department of the Interior to redo and expand environmental studies on the matter.
The DOI is looking into the court decision before taking further action, the Times reports.
“Federal Defendants’ decision not to initiate the [National Environmental Policy Act] process proves arbitrary and capricious,” Morris, who was nominated to the federal bench by Obama in 2013, wrote in his decision.
The next push to overturn Obama’s moratorium on selling coal mining leases for federal land will fall to Interior Secretary David Bernhardt.
Bernhardt took charge of the DOI as acting secretary after Zinke left the department in January. The Senate confirmed Bernhardt’s nomination on April 11.
Trump campaigned on reviving America’s faltering coal industry to save jobs in the sector as well as promote U.S. energy independence from foreign sources.
Do you think federal lands should be open to coal mining?
0% (0 Votes)
0% (0 Votes)
Environmental activists and Democrats have hampered the administration’s progress, claiming that emissions from the sector are worsening climate change and may do irreparable harm to the environment.
Content created by The Daily Caller News Foundation is available without charge to any eligible news publisher that can provide a large audience. For licensing opportunities of our original content, please contact firstname.lastname@example.org.
A version of this article appeared on The Daily Caller News Foundation website.
We are committed to truth and accuracy in all of our journalism. Read our editorial standards.


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"Today we should hold polemics concerning principles of these relations, organization methods of these initiatives. I would not operate today any percentages, shares plants because all this are far from truth, the President said.
Yushchenko noted that today Ukraine and Russia do not hold intentional dialogue concerning characteristics, principles and conditions of relations formation in energy sphere, I think, for today, it is important for two parties to hold correspondent consultations in energy sphere and to form concrete proposals on these of those positions, Yushchenko said.
Yushchenko said that according to Ukrainian legislation, transport thruway is strategic asset of Ukraine and iit s under state management, that's why all concerning its modification demands careful approach. My position on this question will be based on national interests, he said.


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The Melt Stud Earrings
The everyday perfect studs with a killer twist. Fabulously lightweight, these earrings will become your new go to ear accessory.
- This item is handcrafted from 925 Sterling Silver.
- Due to the handcrafted nature of this item, earrings may vary slightly in shape.
- All purchases include a Sa'oti pouch to store and protect your jewelry.
Width: 12 MM
Length: 21 MM
Thickness: 2.5 MM
Weight (The Pair): 6 GM

domain: design


text:
- The average job posting today garners about 250 resumes, reveals recruiting and job-review site Glassdoor.
- Breaking through that much competition takes more than a sharp resume with a few well-placed keywords.
- The key is understanding how companies are using AI to aid them in their search and knowing what information they rely on to decide who gets hired.
Artificial intelligence is at work in your life in all kinds of ways, from providing driving directions on your smartphone to recommendations of shows you might like on Netflix. Here's another way: your job search.
Increasingly, companies are using AI in the screening and hiring process, and that means the way you look for and land a job needs to evolve as well. According to a recent Korn Ferry Global survey of hiring professionals, 63% said AI has altered the way recruiting is done within their organization. Further, nearly half of the respondents said it is making their jobs easier, including giving them valuable insights about candidates they hadn't had access to before.
That last point is key, especially considering that the average job posting today garners an exhaustive 250 resumes, according to recruiting and job-review site Glassdoor. Stories of resume "black holes" abound where job seekers apply for a position online, never to hear another word. Breaking through that much competition takes more than a sharp resume with a few well-placed keywords. It takes an understanding of how companies are using AI to aid their search, and knowing the kind of information that prompts them to decide who gets hired.
It first helps to understand what AI is and how it's being utilized by recruiters. Simply put, AI is technology that enables a computer system to perform tasks that normally require human intelligence, such as decision-making, visual perception and translation between languages.
Lisa Rangel is the founder and managing director of Chameleon Resumes and a former recruiter herself. She says the introduction of AI into the job search means that companies are looking at a candidate's entire online presence and communication exchanges on LinkedIn and Twitter, among others — and not just their resume — and are using that information to parse out whether he or she would be a good fit.
More from Invest in You:
These five resume tips could mean a heftier salary
If you want that job, avoid these five thank-you note don'ts that could lose you that job
Suzy Welch: Want to get promoted? You need to do this one thing
"AI is allowing companies to be more proactive by scouring the internet for information," she says. That includes public profiles such as those on LinkedIn, but it also includes any articles or blog posts someone may have written or if they've spoken at an industry conference.
"The better a candidate is at having a good online presence, the easier it is for recruiters using AI systems to get information about you or to seek you out," Rangel says.
This last part often gets overlooked when people aren't in job-seeking mode. "You don't simply want to pay attention to how you appear online when you're actively looking for a job," she says. AI allows company recruiters to define the kinds of candidates they're looking for in a particular role and then find matches for those qualities. Having a current, robust online presence allows those companies to find you even if you're not looking.
One common move that experts caution against is stuffing a resume full of keywords that you think a recruiter will like. "I call it the gamification of resumes," says Gabriel Fairman, CEO of Bureau Works, a language translation company that uses AI to match translators to the digital content companies post. "Once you know how to game the system with keywords, you can get through the screening process, but it's not a good indicator of whether that's the right job for you," he adds. That's not to say keywords are useless, but like anything else in the professional world, they need to be used smartly and with purpose.
Here, experts give some helpful job-searching tips in an increasingly AI-centric world:
Stay on top of your online presence. It sounds commonsense, but make sure your LinkedIn profile is up to date and has your contact information. Rangel says she often sees resumes that omit that crucial piece of information. "Don't make it more difficult for people to find you," she adds. Similarly, make sure all your online settings are not switched to private.
Use keywords correctly. If the job posting is looking for someone with experience in content marketing, be sure to have content marketing and not content creation or some other phrase on your cover letter and resume. It's not a guarantee you're going to get called for an interview, but not having the exact wording from the job posting will decrease your chances of even making it to the next round.
Become a voice in your field. Something as simple as adding an insightful comment to a LinkedIn post will expand your online presence and help to amplify your voice. When you attend a work-related conference, add something about it to your profile or Tweet about it. AI algorithms are designed to capture information about these events and can help to set you apart from the crowd.
Get comfortable on camera. Some companies are relying less on resumes and more on videos and digital interviews to find their next hire. That's why experts say it's important to invest time practicing speaking comfortably and confidently on camera.
Fairman of Bureau Works says every candidate that applies for a job at his company has to submit a one-minute video where he or she explains a bit about themselves and why they want to work there. Doing so, he says, gives him a better feel for what a person can bring to the company than what he has typically found on a resume.
Pymetrics, a New York City-based company that specializes in using AI in recruitment, works with companies to assess candidates through a series of behavioral science-based tools. They use AI to review the answers and compare the results to those of successful performers in the same role at the company where the candidate is applying. So, a human is still the assessor, but uses a machine learning algorithm to assist in decision-making.
Company CEO and co-founder Frida Polli believes this is the way more companies will be recruiting in the future, because it eliminates natural human biases in the interviewing and hiring process.
It's unlikely that AI will ever completely eliminate humans from the job-hiring process, but it is dramatically changing the landscape. The more you know how to leverage this technology in your job search, the sooner you'll find the position that's the right fit for you.
Disclosure: NBCUniversal and Comcast Ventures are investors in Acorns.


text:
Ambac (AMBC) Reports Q3 EPS of $3.23
- Wall Street surges to new highs; transports set record
- lululemon athletica (LULU) Tops Q3 EPS by 4c; Adj.-Comps Outpaced Views
- Abbott (ABT) Files Complaint to Terminate Alere (ALR) Acquisition
- Costco Wholesale (COST) Tops Q1 EPS by 5c; Comps Up 1%, 2% Ex-Gas
- After-Hours Stock Movers 12/07: (VYGR) (LULU) (HRB( Higher; (OHRP) (VRNT) (CMTL) Lower (more...)
Find out which companies are about to raise their dividend well before the news hits the Street with StreetInsider.com's Dividend Insider Elite. Sign-up for a FREE trial here.
Ambac (NASDAQ: AMBC) reported Q3 EPS of $3.23, versus $2.54 reported last year. Net premiums earned for the quarter came in at $53.2 million, versus $41.4 million reported last year.
For earnings history and earnings-related data on Ambac (AMBC) click here.
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Born in Albany, New York, Richard La Barre Goodwin began his career as a portrait painter, but quickly devoted himself to still life painting. In 1886, influenced by William Michael Harnett's After the Hunt, Goodwin began a series of trompe l'oeil paintings distinctive for their cabin door theme, decorated with hunting and outdoor equipment.
Goodwin's hanging still lifes would have been the ultimate in recognizable and fashionable work of art in the late nineteenth century: "Hanging still lifes first became popular in the 1850s through prints by Currier and Ives after game pieces by Arthur Fitzwilliam Tait. In the mid-1870s, L. Prang and Company published a series of 'Dining-Room pictures' that included game pieces of waterfowl hanging in front of a neutral background. These chromolithographs, reproduced from paintings by George N. Cass and G. Bossett, were destined to decorate many a Victorian dining room and parlor." (E.J. Connell, "After the Hunt," in William Michael Harnett, Fort Worth, Texas, 1992, p. 277)
Richard La Barre Goodwin holds an admirable spot within the context of late nineteenth century still life painting, due in equal parts to his virtuoso technique and to his subtle wit. In few instances are these two attributes so wonderfully displayed than in After the Hunt.

domain: library


text:
We are delighted to welcome Carol Thomas to the blog today to talk to us about her upcoming new release....
- Ann Evans: Hints & Tips for New Writers #10 27th February 2021
- Ask an Industry Expert: Liz Gardner 26th February 2021
- My Indie Journey – So Far so Good – Fiona Mountain 25th February 2021
- Self-publish, traditional – or both? Kindle bestseller Nicola May gives us her opinion 25th February 2021
- Katie Fforde, the RNA and me 22nd February 2021

domain: literature


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LAKE BUENA VISTA, Fla. -- Fresh off of a strong performance in Saturday's Under Armour National Combine class of 2013 safety Marcell Harris (Groveland, Fla./South Lake) was invited to participate in the 2013 Under Armour All-America Game.
The 6-foot-1, 195-pound junior accepted immediately and became the second player from the combine to join the 2013 game. Northeast (Oakland Park, Fla.) wide receiver Stacey Coley accepted his invitation to play in the game on Saturday.
Harris will be the second player from South Lake to participate in an Under Armour All-America Game, joining Class of 2011 alum Nick Waisome.
"I followed the game a little bit and it's a great opportunity to compete at the highest level available to a high school football player," Harris said. "One of my goals was to be part of this game."
Harris is among the nation's top prospects at safety and has already received offers from Florida State, Florida, LSU, Tennessee, Temple and most recently Notre Dame and South Florida.
This past year Harris attended the FSU-Miami game in Tallahassee and the Florida-FSU game in Gainesville.
"It was very excited to check out the big games in the state and see how crazy the fans get," Harris said. "It doesn't really affect my recruitment one way or another but it's fun to see.
"I'm a long way away from making decisions or even getting into a top group of schools. I just want to train hard and take a look at the different programs when I get the opportunity."
He also camped at Florida, Florida State and Texas over the summer. Harris was very impressed with his trip to Austin.
"I love my time in Texas and I know that's one place I want to get back to," Harris said. "The facilities there are beautiful and it's a real nice campus."
"Dad always tells me I'm turning out pretty good but I'm not a knockout hitter like he was," Harris joked. "I have to get a few knockouts to impress him I guess."
"I'm already looking forward to playing about the best guys in the nation," Harris said. "Guys I haven't faced before and haven't seen before.
"Not only is it a great game but it's a learning experience and a chance to pick up on the different styles of play in different regions."
Corey Long has been covering high school football and recruiting in the Sunshine State since 1995. He can be reached at firstname.lastname@example.org.

domain: sports


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An innovation developed at St Michael’s Hospital in Bristol to protect very premature babies from developing cerebral palsy has won a prestigious national Patient Safety Award.
PReCePT, which stands for the Prevention of Cerebral Palsy in PreTerm Labour, was the brain child of Dr Karen Luyt, a neonatologist at University Hospitals Bristol NHS Foundation Trust.
With the support of the West of England Academic Health Science Network (AHSN) back in 2014 and working with both parents and hospital staff, Karen designed PReCePT to help reduce cerebral palsy in babies by administering magnesium sulphate to mothers during early labour before 30 weeks, at a cost of around £1 per individual dose.
Preterm birth is the leading cause of brain injury and cerebral palsy, which has a lifelong impact on children and families. The lifetime health and social care cost for an individual with cerebral palsy is around £800,000.
When magnesium sulphate is given to mothers via an intravenous drip within 24 hours of delivering their preterm baby it can reduce the chances of their babies developing cerebral palsy by 30 per cent.
The West of England AHSN helped to spread PReCePT to all five maternity units in the West Country, and it has been estimated that since the regional project’s launch in August 2014 16 cases of cerebral palsy have been prevented.
As a result of this initial work in the West, NHS England is now funding the national rollout of PReCePT by the AHSN Network (the 15 AHSNs covering the whole of England), led by the West of England AHSN and Karen Luyt as clinical lead. This makes PReCePT the first ever perinatal programme delivered at scale across England, bringing together midwives, obstetricians and neonatologists in all 152 maternity units in the country.
In the first year of PReCePT going national (2018-19), 511 additional mothers in England received magnesium sulphate. An estimated 13 cases of cerebral palsy were avoided nationally, representing a saving of around £10.4 million in lifetime health and social care costs.
Recognising its significant impact on the quality of care for very premature babies and their families, PReCePT won the award for ‘Maternity and Midwifery Services Initiative of the Year’ at the annual HSJ Patient Safety Awards, held in Manchester on Tuesday 2 July 2019.
The award judges said: “This [PReCePT] was on a different scale to the other entries. It has had a huge impact with good engagement from other organisations. The judges were particularly impressed with the patient and parent involvement.”
Natasha Swinscoe, Chief Executive of the West of England AHSN, said: “We’re absolutely thrilled PReCePT has won an HSJ Patient Safety Award and for the success of the programme to be recognised at this prestigious event.
“PReCePT started as a brilliant evidence-informed idea from Dr Karen Luyt at St Michael’s Hospital, which the West of England AHSN helped to spread to all our maternity trusts in the region, using strong quality improvement methodology and involving both parents and staff. And with the coordination and leadership of the entire AHSN Network, it has grown into the national programme it is today, bringing together the entire neonatal community and working with all 152 maternity trusts in England.
“I’m immensely proud of what the team has achieved. Congratulations to everyone who has contributed to PReCePT and made a huge impact on the lives of very premature babies and their families.”
Emma Treloar, consultant obstetrician at UH Bristol and obstetric lead for PReCePT said: “Working with Karen Luyt and being involved in the success of PReCePT at St Michael’s Hospital and the South West is hugely satisfying. Knowing that we are giving the best start to preterm babies born locally and, beyond this, sharing the work of PReCePT nationally is incredibly rewarding. For the programme to be recognised by the HSJ is fantastic for everyone involved.”
Dr Karen Luyt, Neonatologist at UH Bristol, commented: “I’m thrilled PReCePT has won an HSJ Award! It has been amazing to see PReCePT grow from a small programme in the West of England to the national neonatal programme it is today, and I’m really proud to have been part of the team. Congratulations to everyone who has contributed to PReCePT”.
The national PReCePT programme is also running in tandem with the PReCePT Study, a research trial, funded by The Health Foundation and in partnership with local health research body CLAHRC West, which will assess the effectiveness of different approaches to implementing the intervention.
Professor John Macleod, Principal Investigator, CLAHRC West commented: “PReCePT is a deserving winner as it’s a low cost intervention that can make a huge difference to premature babies’ lives. CLAHRC West are proud to be evaluating the programme.”
For more information, please visit: https://www.weahsn.net/news/precept-strength-to-strength/


The BS6 KTM 250 Duke is priced at Rs. 2.09 lakh (Ex-showroom, Delhi)
The 2020 KTM 250 Duke has been launched in India at value of ₹ 2.09 lakh (ex-showroom, Delhi). The 2020 250 Duke will get a brand new LED headlight together with new daytime operating lights, just like the unit on the KTM 390 Duke and impressed by the KTM 1290 Super Duke. The bike additionally will get a twin-channel supermoto ABS mode together with two new colors, that are Dark Galvano and Silver Metallic. The supermoto ABS mode disengages the ABS from the rear wheel and is useful solely on the entrance wheel. It might be activated on the press of a button.
Also Read: KTM 390 Adventure Available With A Special Finance Scheme
Speaking on the event Sumeet Narang, President (Probiking) at Bajaj Auto Ltd. mentioned “KTM 250 Duke is a standout quarter litre motorcycle available for enthusiasts in the premium sport motorcycle segment. The vehicle is greatly inspired by KTM’s unparalleled racing legacy and comes with high-tech race ready engine and components. As a quarter litre KTM it offers the best in biking performance and urban practicality. These upgrades on the KTM 250 Duke will further enhance its appeal amongst the core biking enthusiasts”.
Also Read: KTM, Husqvarna Offer Free Extended Warranty
Few KTM sellers have began accepting bookings for the bike for a token quantity of ₹ 5,000. The 250 Duke continues to be powered by a BS6 compliant 248.eight cc single-cylinder engine which makes 29.6 bhp of energy at 9,000 rpm and 24 Nm of peak torque at 7,500 rpm. In phrases of rivals, it goes up towards the Suzuki Gixxer 250 and its sibling, the Husqvarna 250 Twins.


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Dr Boreham’s Crucible: Paradigm’s ‘ballsy’ move that landed it $35m after an FDA knock-back
Health & Biotech
Health & Biotech
Link copied to
We know that gambling dens aren’t open in these days of social distancing, but metaphorically speaking Paradigm Pharmaceuticals (ASX:PAR) is plonking it all on the black in terms of its “ballsy” pursuit of US approval for its drug for osteoarthritis pain.
On April 6, the company revealed the US Food and Drug Administration (FDA) had knocked back its request for approval based on one phase III trial and “published literature” to confirm efficacy.
Instead, the regulator demanded two “adequate and well controlled” trials, costing $80m in all.
A setback indeed, albeit spun by the company as good news about gaining regulatory clarity. But even amid the COVID-19 market turmoil, two days later Paradigm had raised $35m in a heavily oversubscribed capital raising to fully fund both trials.
CEO Paul Rennie says that one US fund manager dubbed the raising as “ballsy but brilliant”.
“It was ballsy in that if we didn’t raise the money the market would have wondered what had happened,” he said.
“From management’s point of view, it’s a simple and straightforward program. We don’t have to worry about the next raise, which is done and dusted.”
All Paradigm has to do now is to convince the regulator that its repurposed drug is better than the opioid based alternative, which we guess makes the investment in the trials a considered investment rather than a rash bet.
The drug in question is the anti-inflammatory pentosan polysulphate sodium (PPS), a semi-synthetic drug made from beech-wood hemicellulose.
Renamed as the snappier Zilosul by Paradigm, PPS has been used to treat a bladder condition and deep vein thrombosis.
As well as dodgy knees, Paradigm is eyeing other conditions including viral osteoarthritis (Ross River fever) and the rare disease muco-poly-saccharidosis (MPS).
Paradigm listed on August 18, 2015, having raised $8m at 35c apiece.
Paradigm’s driving forces are Rennie and chairman Graeme Kaufman.
Rennie was Mesoblast’s head of product development. Kaufman chaired Bionomics and was executive vice president at Mesoblast (ASX:MSB).
Oh, and he was also CSL’s (ASX:CSL) chief financial officer through the behemoth’s privatisation.
So far Zilosul has been used on about 600 patients, mainly through special access schemes but also in a 112-patient phase IIb trial.
The drug is widely used by 40 to 50 past and present AFL footballers to clear up knee and joint complaints and osteitis pubis. American (National Football League) footballers have also been treated for their creaking joints.
Shortly, the company expects to announce the results of the first 35 patients treated with the product intended to be used in the phase III trials.
Rennie said the clinical outcomes were being measured in the same way as the proposed methods for the phase III trials.
“While it’s not a trial, this data will give insight in terms of how the product is performing … in patients with osteoarthritis ahead the trial,” he said.
By the September quarter the company hopes to have 100 to 200 results on hand.
Paradigm had hoped the FDA would accept the real-world evidence of the drug’s safety and efficacy, but the regulator wanted to see more patients subject to controlled trails.
“We were a little bit surprised but it was not completely out of the realms of possibility,” Rennie says.
“This is Paradigm’s first time in front of the Agency. We put up a good case but it’s not unusual for the agency to fall back to a conservative position.”
He maintains the regulator didn’t have a problem with the data as such.
Paradigm is now preparing to lodge an investigational new drug application (IND), which will pave the way for the US trials.
“We think we have a very clear roadmap not only to IND but also to [a new drug application],” Rennie says.
The first trial will enrol 750 patients and appraise the results after 22 months. The second (confirmatory) trial will enrol 400 patients over 12 months.
The trials will run concurrently, with a 12-month readout of all the patients expected by October 2022.
The endpoint is the same as the phase IIb effort: a reduction in pain from baseline at day-53, as assessed by the 24-question Western Ontario and McMaster Universities (WOMAC) pain scale.
As reported in December 2018, the local phase IIb trial showed that 46 per cent of patients had a 50 per cent or more reduction in pain after 53 days, compared with 22.5 per cent for the placebo group.
The trial injected PPS into the knee and compared it to injected saline. Some have questioned how injected PPS compares to oral – and commonly prescribed – non-steroidal anti-inflammatory drugs (NSAIDS).
The phase III trials will be designed to support a European approval application.
Locally, the company met with the Therapeutic Goods Administration on November 11 last year, in view of obtaining provisional compassionate use approval.
For Rennie, the Remembrance Day pow-wow was unforgettable.
“That was a knockout meeting,” he says. “The TGA agreed there was an unmet medical need for treatment of chronic pain, especially in chronic osteoarthritis.”
The company hopes for TGA approval this year.
Meanwhile, Paradigm plans to lodge a joint scientific advice submission to the FDA and European Medicines Agency, in view of a common protocol for a simultaneous muco-poly-saccharidosis trial.
A phase IIa trial for viral osteoarthritis, or Ross River fever, produced “very impressive results, not only clinical and patient-assessed pain outcomes but good objective data with hand grip strength and other [measurements]”.
Paradigm also has patents for post-operative pain and is working on a respiratory indication, which sounds intriguing in this COVID-19 world.
Paradigm has an exclusive supply deal with the only approved pentosan polysulphate sodium maker, Germany’s Bene Chempharma.
Crucially, Rennie says, the FDA confirmed the company’s view that no-one else would be able to produce an acceptable PPS product.
He says the FDA is “well and truly familiar” with the Bene Chempharma product, especially its “molecule within molecules” structure that can lead to safety issues.
Janssen Pharmaceuticals (Johnson & Johnson) sells an oral formulation of PPS under the name Elmiron, to treat a painful bladder disease called interstitial cystitis.
Otherwise Paradigm has PPS all tied up like pussy’s bow, with patents on the relevant indications in injected oral or topical form.
The patents run until 2035 or 2040.
Rennie says the exclusive supply deal with Bene Chempharma — under which Bene receives a 2 per cent royalty — is as good as patent protection.
While Johnson & Johnson’s patent expired in 2010, no generic alternative has been approved in the US.
“It’s now clear why that’s the case,” Rennie says. “It’s almost impossible for another company to produce the identical product to Bene.”
Paradigm now has $108m in the bank, having raised $78m in a placement and rights offer last year,
Rennie says the company has always worked in “cash preservation mode” — which suits the current zeitgeist to a tee. “We have always tried to have a very low burn rate and continue to do that without massive cost cutting,” he says.
To date, Paradigm has drawn modest revenue from the special access programs here, or the expanded access programs in the US.
“We will continue to preserve cash until we get into the middle of our [phase III] trials, when our expenditure will increase,” Rennie says.
The latest raising was done at $1.30 apiece, a 23 per cent discount to the prevailing price of $1.69.
While the stock has held up well post-raising, it’s well off the peak valuation of $4.35 just before the February market meltdown. Over time they have traded as low as 26c.
Paradigm has a legion of supportive retail holders, with the latest raising bolstering the institutional component on the register.
But it’s not all backslapping at 10 paces, with broker Morgans dubbing the phase IIb (and follow up) osteoarthritis results as “unconvincing and lack[ing] substantive clinical evidence”.
“We view the osteoarthritis data as an interesting trend,” the firm says in a research note. “But it will likely require a more stringent trial design and analysis to flush out critical design parameters for a phase III trial and draw out a realistic commercial opportunity.”
Morgans had the stock as a “reduce” — a polite way of saying sell — on February 17, when the stock traded at $4.17. It has since upgraded to a “hold”, but remains wary that the US trials will be costlier and longer than originally expected.
Rennie protests that regulatory submissions are “time consuming and exacting” and he’s well aware of the number of drug developers stymied by sloppy paperwork.
“It’s better to answer the regulator’s questions fully; otherwise we will get knocked out,” he says.
In the US there are 31 million osteoarthritis sufferers (and 3 million here), so the condition is hardly confined to battle-weary professional athletes.
“Managing chronic pain is a major unmet medical need, especially in relation to opioid overuse and as we get older,” Rennie says.
Depending on the drug’s pricing, achieving a 10 per cent US market share would generate annual revenue of $US6.2bn ($9.7bn) to $US9.3bn ($14.5bn).
Rennie notes that drugs that meet an unmet clinical need are generally recession proof. And as mentioned, Paradigm faces little or no competitive threat.
The benefit of repurposing a drug is that developments costs are much lower: $US30m to $US50m compared with an average $US1.3bn for a drug from scratch.
The chances of commercial success are also boosted, while the timeline to market is shortened from 15 years or more to perhaps fewer than five years.
Rennie acknowledges that while Paradigm has the non-osteoarthritis rare diseases programs, the osteoarthritis efforts will make or break the company.
“The reality is that if your lead program fails, you are on Struggle Street,” he says.
Disclosure: Dr Boreham is not a qualified medical practitioner and does not possess a doctorate of any sort. Hopefully he is ballsy and brilliant enough to stay off Struggle Street.

domain: medical


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Here you’ll find detailed description of the most common dog and cat breeds available in the Lower Mainland, Fraser Valley and Pacific Northwest regions. If you are searching for a dog or cat breed, we hope this information helps you select the most compatible breed for your family. Our FAQ area will be updated regularly and are answers to the many questions we receive from our clients.
604.855.8900 firstname.lastname@example.org Facebook Twitter Book an Appointment Request a Prescription Emergency Info
Every puppy is cute and adorable, but what will it look like in two years? Search through this page carefully to help choose a dog that is right for your family. See Dogs →
Cat breeds are unique in their appearance, coat care, allergenicity, personality and common health concerns. See Cats →
Frequently asked questions about the care of your pet. Learn More →


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The distance from Dallas Love Fld to Austin Bergstrom Intl is 189.07 miles or 304.22 Kilometres.
Flight Time Approximations: How long would it take to fly from Dallas Love Fld to Austin Bergstrom Intl? If you were in a Boeing 747 and maintained an average cruising speed of 450 mph (724.1 kmh) through the duration of the flightit would take you around 0.9 hours to get from Dallas Love Fld to Austin Bergstrom Intl. Flying estimates include a 15 min buffer for take off and landing.
Airport Name: Dallas Love Fld City: Dallas Country:United States Location: Latitude 32.847111 Longitude -96.851778 Elevation 487ft 3 letter Code DAL
. Timezone is GMT -6
The following airlines are reported to fly out from Dallas, United States:Continental Airlines, Copa Airlines, Delta Air Lines, Southwest Airlines, United Airlines,
Airport Name: Austin Bergstrom Intl City: Austin Country:United States Location: Latitude 30.194528 Longitude -97.669889 Elevation 542ft 3 Letter Code AUS
Timezone is GMT -6
The following airlines are reported to fly out from Austin Bergstrom Intl, Austin, United States:Air Canada, Alaska Airlines, American Airlines, bmi, Continental Airlines, Copa Airlines, Delta Air Lines, El Al Israel Airlines, Frontier Airlines, Gulf Air Bahrain, JetBlue Airways, KLM Royal Dutch Airlines, Lufthansa, Midwest Airlines, Southwest Airlines, United Airlines, US Airways,
For a full list of airports for United States visit the United States airports page.
United States Airports
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domain: travel


I’m having an issue with JP13, 25,29, and 12 on the 7U 104 case.I noticed one of my modules functioning different and thought it was the module. Tried a different connector on the other side of the board and it worked fine. All 3 LEDs are lit on the busboard. It’s just that corner of terminals not working. I don’t know how this started happening, but yesterday when I powered them on I noticed this.
Please e-mail email@example.com
Oh, sorry, thought maybe it was a user error. Will do.


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Christina Hendricks @ “Ginger & Rosa” AFI Fest 2012 Screening
Christina Hendricks was amongst the attendees of the AFI Fest 2012 screenings of Ginger and Rosa and Zaytoun. Zaytoun is an Israeli film starring Stephen Dorff while Christina stars as Natalie (Ginger’s mother) along with Elle Fanning (Ginger) and Alice Englert (Rosa) in Ginger and Rosa. The film premiered at Toronto International Film Festival and has already been released in the UK. No word on a US release.
London, 1962. Two teenage girls – Ginger (Elle Fanning) and Rosa (Alice Englert) – are inseparable. They play truant together, discuss religion, politics and hairstyles, and dream of lives bigger than their mothers’ frustrated domesticity. But, as the Cold War meets the sexual revolution, and the threat of nuclear holocaust escalates, the lifelong friendship of the two girls is shattered – by the clash of desire and the determination to survive. [Wiki]

domain: entertainment


Yesterday, Senator Russ Feingold introduced a Senate resolution to censure President Bush for the NSA's 'illegal' international terrorist surveillance program. Bill Frist proposed to put Feingold's resolution on for an immediate vote, but the Democrats blocked a vote, preferring to let the measure draw headlines in committee for a while longer.Feingold wantspresidentor presidnet, and somehow has to get to the left of Hillary. This is just his latest stunt.
Those with a sense of deja vu may recall the similar episode of Congressman Jack Murtha's resolution calling for immediate termination of the Iraq mission. The Democrats hailed Murtha's courage and welcomed the headlines that followed--did you know that Murtha is an ex-Marine?--but considered it dirty pool when the Republicans actually wanted to vote on Murtha's proposal. The vote was something like 402-3, but no matter--the Democrats got anti-administration headlines, which is what they were looking for.
Feingold's absurd resolution will meet a similar fate when it is finally voted on, but by then the Democrats will have moved on to something else--something equally frivolous, in which the news media will cooperate gladly. All of which may cause some voters to wonder how serious the Democrats are about the issues that concern the American people.
UPDATE: Not too many saluting Russ' flag:
The referral averted a debate and a vote that Democrats privately worried would alienate voters who could decide close elections. Throughout the day, Feingold's fellow Democrats said they understood his frustration but they held back overt support for the resolution. Several said they wanted first to see the Senate Intelligence Committee finish an investigation of the warrantless wiretapping program that Bush authorized as part of his war on terrorism.


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Bewertung und Feedback des Lernenden für Create a Flyer using Libre Writer von Coursera Project Network
Über den Kurs
After successfully completing this project, you will have created a visually appealing flyer using Libre Writer.
While building a flyer, you will use various features in Writer. You will use the insert feature to insert a picture in a document then modify it. Other features you will use include applying styles to text and formatting text. You will insert a numbered list, convert it to a bulleted list, and then modify the bullets....

domain: artistic


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Will and Kate are back, but the show’s star won’t be on the show, according to the Hollywood Reporter.
According to the website, Will and Ben Affleck will not be on “Famous” this year after “The Hangover: Part II.”
Affleck is also set to star in “The Muppets,” a remake of the Broadway musical.
The magazine said that “Fame” creator Lorne Michaels and “The Weinstein Company” had not yet confirmed the news.
Fame, which premiered on September 17, 1993, was the first scripted series to be canceled by the network in a quarter century.
In addition to the series, “Famously” also featured other celebrities like Michael Douglas, Natalie Portman, Robert De Niro and Brad Pitt.


SKF Bearing 23088CAK/W33 design bearings have two stamped window-type steel cages, an inner ring without flanges and a guide ring centred on the inner ring. The CC design is indicated by the designation suffix C or CC. Large CC design bearings with the designation suffix EC or ECC have an optimized internal design for increased load carrying capacity.
SKF Bearing 23088CAK/W33 design bearings have two stamped window-type steel cages, an inner ring without flanges and a guide ring centred on the inner ring (d ≤ 65 mm) or on the cages (d >65 mm). They have an annular groove and three lubrication holes in the outer ring. SKF Bearing 23088CAK/W33 design bearings are indicated by the designation suffix E. All E design bearings have an optimized internal design for increased load carrying capacity.
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I'm managing my own website and there is one last thing that I wanted to do but can't for the life of me figure out.
I am using an inline block to create a nav bar, and I have a float for all of the "list items." What I am trying to figure out is how I can have the list items conform to the page/window size along with the block. I feel like I have tried everything so I would love for someone to prove me wrong!
Not enough information provided. We need to see your HTML and CSS code. A working test page online would be best.
Rethink the concept. Menu is not usable in it's current state unless people are on a very large screen. My advice is to find a responsive menu system that starts out horizontal on large devices & collapses and stacks vertically on smaller ones.
Bootstrap's default navbar does all that without much fuss.
Code tutorials: Bootstrap Navigation Bar


From the tax perspective, what was not said in the Queen’s speech was as significant as what was said.
Let's start with what we know. A National Insurance Contributions Bill will legislate for NIC changes announced in Budget 2016 and Autumn Statement 2016. We think these changes will relate mainly to the abolition of class 2 NIC and also to ‘disguised remuneration’. Documents published with the Queen's speech indicate that the March 2017 Budget proposal to reform class 4 NIC for the self-employed, which were abandoned as a result of protests, will not be reactivated. There will also be a Customs Bill to ensure that, after Brexit, the UK has stand-alone regimes for Customs and for VAT.
This takes us to the less certain areas. The legislative programme for this parliament will include three finance bills to implement Budget decisions. Following the pattern laid down by Chancellor of the Exchequer Philip Hammond, one of these is likely to be published in autumn 2017 with legislation which will come into force in April 2018. Similarly, as this is an extended session of Parliament, there will be another finance bill in autumn 2018, with provisions coming into force in April 2019.
This brings us to the third Finance Bill promised in the Queen's speech. This will be the Summer Finance Bill 2017 which could in principle be published relatively soon although we do not yet have a date for this. Nor do we know the content apart from a general statement that it will include a range of measures including those to tackle tax avoidance.
On 24 April, the government and opposition agreed to withdraw all the proposed changes to the taxation of non-domiciled individuals that were due to have taken effect from 6 April 2017. Regardless of whether one thinks that this legislation is a good or bad thing, it had been drafted after careful consideration and wide consultation. Given all of this work, the decision to withdraw the legislation after the date it was due to take effect came as a surprise to many.
It might be thought that withdrawing the legislation would be good news for non-doms, since the proposed new rules are stricter than the existing ones. In many cases, however, this will not be true. Because the new rules were due to apply from 6 April 2017, many non-doms have acted already based on the draft legislation, by selling assets relying on a new rebasing relief, and by bringing funds to the UK relying on a new cleansing relief. Both reliefs have currently been withdrawn, potentially creating large tax bills for the people who relied on them.
On the face of it, it would be a simple matter for the government to reinstate the draft legislation in full, and for it to be enacted with a commencement date of 6 April 2017. This would provide certainty to all concerned, and would reflect the way that many non-doms acted in good faith to prepare for the expected introduction of this new legislation. However, as the saying goes, that was then and this is now. It is not beyond the bounds of political possibility that other parties in Parliament might wish to reopen the debate on the non-dom legislation and change it, perhaps making it even tougher than it already is.
Making Tax Digital (MTD)
By contrast with the non-dom changes, MTD will affect most individuals and businesses in the UK. It’s in everybody’s interest that MTD should operate as intended. Compliance with the filing requirements of the tax system should be as simple and certain as possible for everybody. But that won’t happen if the project is rushed, if pilots are inadequate, if the software cannot cope.
Even before MTD is introduced, HMRC seems to have given up the battle to provide software which allows people to file their tax returns in accordance with the law of the land. The current online self-assessment filing software used by HMRC, and specified by HMRC for independent software houses, is known to be incorrect in certain circumstances. That means many people will this year not be able to file correct returns online. They will have to use paper instead. On its own, this would be bad enough. But against the background of the rush to implement MTD, it's little short of a national disgrace.
Despite concerns expressed by parliament in its last session, and notwithstanding some small concessions granted by the Chancellor of the Exchequer, we are concerned that MTD will be pushed through with both businesses and individuals suffering a botched introduction.
Ministerial fiat is not sufficient to guarantee success. Parliament must be given proper time to scrutinise the legislation which will underpin MTD. I still have a major concern that a much more radical overhaul of the taxes acts will be required to bring the machinery of tax administration up to date. We already know from many recent tribunal decisions that the legislation, and associated HMRC practices, is creaking under the strain of the existing system. In the debates on the Queen's speech, we therefore hope that MPs will challenge the ministers responsible for HMRC to explain why they are allowing inaccurate software to be used this year, and what they will do to guarantee that MTD will achieve its tax-raising objectives without imposing impossible and contradictory demands on businesses and individuals.
For more information please contact George Bull, or your usual RSM contact.


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Stamp Garden (25 stamps, 2 ink colors, assorted plant and flower parts, perfect for scrapbooking, printmaking, diy crafts, and journals), by Bickford-Smith, Coralie
Note: Supplemental materials are not guaranteed with Rental or Used book purchases.
- ISBN: 9781616896805 | 1616896809
- Cover: Package
- Copyright: 3/20/2018
Grow your own garden with this set of high-quality rubber stamps and two colored ink pads. The sturdy matchbox-style box features twenty-five wood-backed stamps in an assortment of shapes and textures, from leaves and stems to buds and petals—even a bee! A verdant kit of parts, Stamp Garden contains all the botanically inspired pieces you need to cultivate an imaginary garden, beautiful bouquet, or botanical pattern—the combinations are infinite.


The Martin Pickett Quintet featuring Steve Waterman & Mark Bassey is arranging a PRS funded jazz tour.
Pianist and composer, Martin Pickett, is launching a new quintet in a series of concerts across the UK, starting in late summer 2010. The Martin Pickett Quintet, features the combined talents of 3bpm, a trio of which Martin is a founding member and leading jazz figures, Steve Waterman on trumpet and flugelhorn and Mark Bassey on trombone.
3bpm has performed as a trio for several years now and developed a reputation for their unique combination of tight arrangements and fearless exploration within the contemporary jazz mainstream.
Both Steve and Mark have well-established reputations as leading figures in their own right, on their respective instruments. Hard won reputations, earned through complete mastery of their instruments and a musical sensibility that puts the music first.
All the musicians involved have a wide range of musical experience that allows them to move freely within the whole array of musical influences at work in the music, from bebop to brass band, to the diverse scope of contemporary jazz.
The concert repertoire will consist mainly of original music composed by Martin. Some pieces have been specially written for the project while others, more usually performed on piano, double bass and drums only, have been given new treatments to reflect the change in line up. Inspiration is drawn from a variety of mediums, with five pieces influenced directly or indirectly by verse. Some are literal instrumental settings while other use the rhythm and form as a starting point for freer creation. This sits well with the fundamentally lyrical nature of all Martin’s music, whatever the stylistic influences.
“Martin’s originals standing favourably against such gems as….”
Keith Ames ‘Musician’ Summer 2008
“their debut album features a strikingly conceived programme of pop and folk songs plus three excellent originals by Pickett”- ‘First Hearing’ by 3bpm SLAM 274 CD
Andy Hamilton, Jazz Review, April/May 2008
“and the rendition of a Shakespeare song, Come Away – music by pianist Martin Pickett – are among the CD’s highlights”
Irwin Block, New Music Reviews, The Montreal Gazette, March 31, 2005
Listen here: www.martinpickettmusic.co.uk/audio/nocturne.mp3


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COVID-19 UPDATE: We are still shipping orders and also doing embroidery & print. Will provide updates here!
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Hospitals get new interns but MB2 Dental gets their new recruits as well each year. This group composed of multiple dental practices is watchful as they await the arrival of new recruits each year into the dental profession. The last event of the year specifically for recruitment ended on April 20, 2017. This event was specifically for the Texas A&M College of Dentistry. Having visited with students from around Texas, the group was focused on getting these dental students prepared for what they would face in their first year of dental practice. Their approach was to give them resources and networking opportunities to help them choose a practice that they would potentially enjoy working with long-term.
The CEO of MB2 Dental, Dr. Chris Steven Villanueva, mentioned that the reason that they hold these events is because they want to reach out and build relationships with the future doctors of the dental profession, especially in Texas. Educating these students on what is available to them after they graduate is crucial for them to successfully launch their new career. This means that if they can establish relationships with the doctors of the future, and they can find ways to nurture those relationships, they are more likely to secure the most viable candidates for long-term success. Learn more about MB2 Dental on monster.com.
The MB2 Dental team, made up of numerous dentist-owned practices feels more than fortunate to have connected on a personal level with so many qualified candidates. The Texas A&M College of Dentistry event is held each year at Chelsea Corner in the Knox Henderson area. They felt privileged when they discovered that many of the students were 3rd and 4th year dental students.
The setting is personal, with those doctors that are owners and the students enjoy gourmet pizza in a casual setting, with other fine foods and drinks, and converse about the dental profession, what it has to offer and how one can achieve massive success in their practice. The goal for these doctors is to meet another potential doctor that can help elevate their practice in an attempt at getting greater results overall than they could have imagined otherwise. The leadership here is close-knit regardless of the fact that the participating doctors are not all located within the same state.
MB2 has continued to play an integral role in the future of dentistry as experienced doctors continue to step forward and show that working together is better than working alone. Additionally, these doctors have encouraged new doctors to focus on playing just as hard as they worked; helping them see that there is a great need for a balance in work and life.
This group, MB2 Dental serves as a partner to affiliated doctors that wish to participate, encouraging upcoming dental graduates to find their practice of choice. They also offer assistance with services, sharing the most innovative ways to efficiently run a dental practice.
Know more: http://mb2dental.com/


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Many people dream of making it big in Hollywood, but one of our own Scioto County boys has done just that and continually makes his hometown proud.
Jacob Tolliver grew up in West Portsmouth and has been performing live shows since 2008. Tolliver siai he took piano lessons when he was in the third grade from Mary Smally also of West Portsmouth. Unfortunately, it only lasted about nine months. He said that she went to his parents and said something like it just wasn’t a good fit for him. He said that their talents did not align. She said he was reading all the notes properly, and he said he was doing everything improperly. He didn’t like piano lessons at all. He said he did a play for about five years.
Tolliver told of his next time working with music, “I was cleaning my bedroom one day, and I had my keyboard under there and I plugged it in, dusted it off, and started playing. I was playing a kind of like rock and roll baseline, and my dad was walking through the house and popped his head in my door, and asked if that was me and I said yes, and he said, ‘don’t stop, you’re into something.’ So, the rest is history. I guess as for the piano lessons, I wanted to play by ear and my ear took over more than what my eyes were doing on a page.
Tolliver laughed when asked where he lived most of the time, as he said, “they tell me Los Angeles, it’s where I pay my rent, but it seems like I’m never there.” He said he had been out there for about two years now. He has been in Nashville, Tennessee quite a bit, writing and working with Rick Ferrell. “He and I are coming up with some really good stuff, and between all the shows everywhere, I’ve been everywhere, but here.”(LA) He said he does really like it there, but he wasn’t sure if he would have if he had moved there first from Ohio. “It is different, going to Vegas from Ohio. Vegas is so different, it’s a dry oven, the desert. So, after being there four years, coming to LA seeing water, trees, and grass it’s kind of like a feeling of being back home sometimes.”
He told a story of when he was three years old, before he ever really knew what Hollywood was, “I told my grandmother and parents, I’m going to go out to Hollywood and help Steve one day.” He was referring to “Blues Clues’s Steve, that he watched all the time as a boy.
Tolliver’s parents still live here in Scioto County on the West side, so he tries to get here as much as he can. He will be in town for the Winterfest that is being put on in Portsmouth. On December 15th, he will be here for the record breaking Caroling Event that they are holding there. Mike Reiss and he will be emceeing, playing two or three Christmas songs, and emceeing the rest of the evening.
When asked about all the people he has worked with since being a well-known artist, he immediately said Jerry Lee Lewis was his favorite. He is currently touring with him right now. “It’s incredible, that we line up with so many parallels so well musically, and I am a better match than anyone else would be. I enjoy it so much, if you would have told 13 or 12 year old me that I would actually be opening up for Jerry Lee, I would have told you, you were lying. It is really a life changing opportunity to do that. My goal is to keep that rock and roll piano torch alive and him allowing me to open the show, letting that happen and endorsing that, it’s really an incredible thing.”
He humorously said that all he dreamed of was working with stars like Jerry Lee. He says to people when asked this, “I made it happen, it’s something I’ve always wanted to do and be a part of, there’s something about being able to be a known musician. You make people happy, life is always good, because people are coming up to you and you’re making people’s days all the time. It’s a cool spot to be in to have that talent and God given gift, to make people happy, is again incredible.”
Tolliver spoke of working with Jodie Sweetin, from ‘Full House and Fuller House,’ on the single, they have released together, “Santa Baby.”
He was at the age, where he watched Full House as a kid, and said it was a kind of weird experience. He said he found himself a few years back, kind of emerged in this Full House family through friends of friends. “I got introduced to the creator of Full House, Jeff Franklin, and Jeff has become one of my best friends now. He hosts these crazy outlandish Hollywood dinner parties, everybody in the world come to these parties. The way it works, Jeff hosts a dinner and then afterwards, he kind of moves everybody into his living room, where there’s a big grand piano and he has a mini stage set up, and people just start jamming and then it turns into a big jammin’ night. You have Tom Jones singing until 5 a.m. in the morning, or the Beach Boys or the Rolling Stones showed up one time and because of Jeff being the creator of Full House, you naturally have all the cast of Full House end up being at these parties. I eventually became close to a lot of these people and some are like family and Jodie being one of them. It kinda of naturally happened, because a few years ago, Jodie took up an interest in singing and Jeff gave her a song on Fuller House and she performed it on the show and then sold it on iTunes.”
Tolliver continued, “We eventually started doing duets at these parties, just playing around. Then last year, I asked her about doing a song and that’s how ‘Santa Baby’ came about.”
Tolliver has shows leading up to next year and he said, “I have recently recorded an album and that will hopefully come out sometime next year. I have another single that will not be on the album. In the meantime, Rick and I will be writing and probably have enough now to go in the studio and have a great album of material. We have a big selection to pick from. Hopefully by the second half of the year, we’ll be in the studio recording my originals. I absolute love to write my songs. Being that we both grew up on the West side, he’s really helping to tailor songs directly to me. Lyrically, I m not the strongest, so Rick’s more the words and we are both more the music. It has been great and the system we have, works well. We are both super excited, it has a super sound, it’s very Jacob Tolliver.”
Tolliver has also done some acting and says that he would like to act again. “It’s really hard being able to balance both sides of the coin. You’re kind of either putting all your eggs in the musician basket or all your eggs in the acting basket. So, I haven’t been able to do as much as I’d like to, but I will do it again.”
Where he would like to, be in ten years, he said he would like to be selling out every arena across the world. He would love to see himself in a position, where he changed the world, like Jerry Lee changed the world. The goal is never to copy anyone, but to keep this torch alive, going on an upwards trajectory, to keep the piano crazy vibe from disappearing. “Jerry was among ten others who invented a musical genre, the odds of me creating a musical genre are slim.”
Tolliver wants to be that musician that makes people happy and clap and sing to his work, “and change people ‘s lives for the better, because of the God given gift I have.” He had just turned 25, a few days ago and said he got to spend it with Jerry Lee. He said he had never walked away from Jerry Lee, not learning something, whether he’s onstage or shooting the breeze or whatever it is. “There is always something I learn, it’s incredible, he has amazing stories, he truly is a gentleman. At the end of the day, he is a normal guy living a normal life. He and his family have all become close with me, and I’m having Thanksgiving dinner with them.”
Tolliver wanted to mention that ‘Santa Baby’ is down loadable on all platforms, iTunes, Amazon, Google Play, and Apple Music. He also wanted his fans to know that his social media handles are all just his name, Jacob Tolliver, and he has a new site available, JacobTolliver.com
Jacob Tolliver has come a long way, since those early days of piano lessons, but he is a young man that has reached his childhood goal of becoming successful, and yet, he has never forgotten where he came from and still loves to come home, when he has the time.
Reach Kimberly Jenkins (740) 353-3101 ext. 1928


text:
A love story about a love so enduring it lasts through 40 years of separation...
Millions of Blackie Ryan fans will be thrilled with his return in this exciting novel of mystery and suspense. Bestselling novelist Andrew M. Greeley has captured the imagination of the mystery reading public with the improbable Bishop Blackie Ryan, who works for the aristocratic, haughty, sometimes arrogant but often slyly good humored Sean Cardinal Cronin, the Archbishop of Chicago. The Vatican has just assigned auxiliary Bishop Gus Quill to the Archdiocese of Chicago over the violent protests of Archbishop Sean Cronin, and the not so silent protests of Bishop Blackie. Bishop Quill is under the illusion, one might say delusion, that he has been sent from Rome to replace the good Cardinal when in fact Rome was dying to get rid of him because of his incompetence. Immediately on arriving in Chicago, he manages to disappear while riding the L Train and it is up to Blackie to find him. As the Cardinal says, "The Vatican does not like to lose bishops, even auxiliaries. " And thus begins the search for the missing bishop who no one really wants to find. Of course, none of this is too much for the intrepid little Bishop Ryan. He faces these problems squarely and, with the kind of deductive mind reminiscent of G. K Chesterton's Father Brown, manages to find solutions to some of the most baffling mysteries he has ever encountered.
Andrew M. Greeley's bestselling sleuth meets The West Wing. Blackie Ryan in the White House? Yes! Sent there by his estimable but irascible boss, the Cardinal Archbishop of Chicago, Sean Cronin. Blackie gets a call from his friend, the newly elected Democratic president, Jack Patrick McGurn whom the media has seen fit to call Machine Gun McGurn but of course the call is interrupted by the autocratic Cardinal Cronin. Cronin, without consulting Blackie, sends him off to the White House to solve a poltergeist problem. Ghosts in the White House? Of course. Blackie encounters a great deal more than ghosts; an evil spirit out to get the President, a right wing conspiracy, and four beautiful women, any one of whom could be contributing to the mischief in the West Wing. How Blackie solves the problem of the ghosts and the conspiracy, and perhaps even finds a beautiful wife for the lonely, recently widowed President makes The Bishop in the West Wing the best Blackie Ryan mystery yet.
Examining the religious imagination that shapes Catholics' lives, Greeley discusses the central themes of Catholic culture: Sacrament, Salvation, Community, Festival, Structure, Erotic Desire, and the Mother Love of God.
15 new fantasy stories by talented, award winning, popular authors edited by Andrew M Greeley. Diane Duane humorously writes about how the murder of leprechauns in modern Dublin is halted. Tanith Lee's muse, a Speir-Bhan, helps a musician rid the land of 3 beautiful Goth women who are murderous shape shifters. Jane Yolen and Adam Stemple describe a violent pub brawl where the combatants are the Fair Folk. Judith Tarr's lonely hermit finds romance as he rescues the magic folk from extinction. Elizabeth Haydon's Merrow, a mermaid, is a loving wife and mother who rescues her son from starvation during the potato famine. Disrespecting The Butter Spirit almost results in broken hearts and a lost soul in Charles De Lint's suspenseful story. Ray Bradbury creates a beautiful but deadly banshee. Andrew Greeley's Faeries could be angels who prefer Ireland to heaven. Jane Lindskold offers a unique take on the love of a famous poet's life. Fred Saberhagen concocts a shocking blend of vampires and literature. Peter Tremayne's characters pay a chilling price for their chance to be discovered in the music world. Cecilia Dart-Thornton's hero gains love in the land of eternal youth, but can he keep it? L. E. Modesitt, Jr. weaves Irish magic together with interstellar flight. Jacqueline Carey's heroes decide between remaining with their beautiful lovers and continuing their quest for revenge. A stray cat is the salvation of a lonely little girl in the final story by Morgan Llywelyn. Readers may find other titles to try in the short biographies of the authors given at the end of the book.
Petey Pat Kane and Mariana Pia Pelligrino have been in love with each other their whole lives. But on a night that is supposed to be one of the best of their lives, Peter makes a choice that forces him to leave Chicago - and Mariana - behind. Guilt leads him into the Army, where he becomes Captain Kane, war hero. But nothing can make him forget his love for Mariana. On his third deployment in Iraq, Peter is injured and finds himself both alive and dead on a wondrous spiritual journey where he is given a second chance at life from God Himself. With Christmas approaching, time is running out for Peter to complete the most important mission of his life: convincing himself that he and Mariana were meant to share a special message of love with the world.
Day O'Sullivan blames himself for a vehicular homicide he may not have committed. His family wants to pin the crime on him, which leads Nuala and Dermot to wonder who really ran over Rodney Keefe.
The veteran Greeley plots this latest work with some admirable cunning, which shows up clearly in a highly believable trading expos and in the exacting re-creation of the supposed death of an enigmatic crime lord from Capone-era Chicago. Unfortunately, it all counts for naught beside the truly tiresome twosome around whom this third book in a series (after Irish Gold and Irish Lace) revolves. Nuala Anne McGrail is an Irish beauty with a fine singing voice, all kinds of sexy outfits, a job as an accountant and the gift of second sight. She talks dirty, likes to be fondled and must be the least likely virgin featured in recent literature. Her dutiful betrothed is Dermot Coyne, who also doubles as the narrator. A former commodities trader who's now a bestselling author, Dermot is currently under investigation for the $3 million he netted during his brief trading days. When Nuala "sees" an empty coffin in a cemetery plot, the hunt for a missing corpse is on. The shooting death of Jimmy Sullivan, onetime rival to Al Capone, emerges as just the kind of long-unexplained mystery that exactly suits Nuala's otherworldly gifts and Dermot's dogged legwork. Dermot's trial is fun, and so is Jimmy's turbulent history. But the lovers' dialogue is laughable with its lewd promises for the upcoming wedding night. And then there's Dermot's continuous declarations of his endless devotion and the lustful attention Nuala elicits from every breathing male in Chicago. One might be tempted to opine that Greeley knows less about love (or lust) than he might think. Library Journal
4th title in the Nuala Anne McGrail series
'We must begin our story of Jesus by granting him permission to surprise us endlessly....' ---from the Introduction Jesus of Galilee taught through stories, which even today contain the power to startle us out of our prejudices and preconceptions. Now Father Andrew M. Greeley, one of America's most beloved storytellers, examines the parables told by Jesus in search of a fuller understanding of the man and his message.This engaging and informal collection of homilies reveals a Jesus whose simple parables carry profound lessons about the Kingdom of Heaven. Along the way, Father Greeley touches on such provocative topics as the significance of Jesus's Jewish roots, his deep and revolutionary relationship with women, The Da Vinci Code, and The Passion of the Christ. He also singles out the four greatest parables, which best illustrate the infinite love and mercy of the God whose kingdom began with Jesus and continues even today.As a storyteller, Jesus often surprised his listeners with unexpected twists that challenged them to see the world in a whole new light. Father Greeley's insightful tour of the Gospels provides a fresh look at the parables that strips away centuries of false and mistaken interpretations to get at the essential truth of who Jesus really was and what he believed.
Father Herman Hoffman, in his first parish appointment, witnesses child abuse in the parish rectory. He tells the pastor, the father of the victim, and the police but is rebuffed by the archbishop.
Chicago attorney Brendan Ryan is a classic "Quiet Man" but passion can transform even the mildest man into a fierce fighter ready to ruthlessly defend the woman he loves.
It was during the summer of 1938 that Michael Cronin decided that his elder son, Paul, was to become president of the United States and that his younger son, Sean, was to become a priest and "probably a cardinal." The decision was made spontaneously, without reflection. Nonetheless, it was permanent and irrevocable.
Select your format based upon: 1) how you want to read your book, and 2) compatibility with your reading tool. To learn more about using Bookshare with your device, visit the Help Center.
Here is an overview of the specialized formats that Bookshare offers its members with links that go to the Help Center for more information.
- Bookshare Web Reader - a customized reading tool for Bookshare members offering all the features of DAISY with a single click of the "Read Now" link.
- DAISY (Digital Accessible Information System) - a digital book file format. DAISY books from Bookshare are DAISY 3.0 text files that work with just about every type of access technology that reads text. Books that contain images will have the download option of ‘DAISY Text with Images’.
- BRF (Braille Refreshable Format) - digital Braille for use with refreshable Braille devices and Braille embossers.
- MP3 (Mpeg audio layer 3) - Provides audio only with no text. These books are created with a text-to-speech engine and spoken by Kendra, a high quality synthetic voice from Ivona. Any device that supports MP3 playback is compatible.
- DAISY Audio - Similar to the Daisy 3.0 option above; however, this option uses MP3 files created with our text-to-speech engine that utilizes Ivonas Kendra voice. This format will work with Daisy Audio compatible players such as Victor Reader Stream and Read2Go.


text:
Author : LolaJ.Park.
Published : Sun: Sep 15 2019 :4 PM.
Format : jpg/jpeg.
Types of Family Tree Template Charts There are 2 basic types of charts used to record family genealogy. I. Ascendant Charts II. Descendant Charts
If you want to step things up to be a little more fun, you can go for a huge, ancient looking tree. These usually look great as they carry the feeling of the project. The ancient tree, gnarled roots and old-looking leaves give it an authentic feeling of history. They can be detailed too, but because you already have the tree taking up some room, you might not want to put in as many notes, maybe just names and years.
The pedigree chart starts with you placed on the left side, in the middle of the page. To the right of "you" are placed the details of your mother and father. Then you enter your father`s father and mother, and your mother`s father and mother. Then you enter the parents of your parent`s parents and keep going. Each Pedigree chart has a continuation reference number, and an individual reference number that allows you to link multiple charts together.
There are a lot of free family tree chart designs available for downloading. These graphical representations will help you organize your ancestors and relatives. There are a lot of designs available for every personality and taste. What`s great about these free family tree charts is that they can help you add names and dates electronically, usually using your browser window. These charts make it very simple to keep tabs on your progress, because with one click, you can see right away what boxes still need to be filled out.
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Beginning with you, it works up to your parents, adds in your siblings, then goes up to your grandparents, then out to your aunts, uncles, cousins, and as many names as that particular worksheet will hold. These sheets are usually fairly extensive, so they will probably use up all the names you can remember before you managed to fill in every square. However, if you need more space, you may not even need a worksheet to continue.


If you’re a regular user of Getintopc.ink, you may have come across the term “Getintopc password” before. But what exactly does it mean? In this article, we’ll explore what a Getintopc password is, why it’s important, and how to use it properly.
What is a Getintopc Password?
A Getintopc password is a password that you use to access certain features of the Getintopc website. This may include downloading certain software or accessing premium content. The password is unique to each user and is designed to protect the security of their account and personal information.
Why is a Getintopc Password Important?
A Getintopc password is important for several reasons. First and foremost, it helps protect your personal information and account from unauthorized access. Without a strong password, hackers or other malicious individuals may be able to gain access to your account and steal your personal information or use your account for nefarious purposes.
Secondly, a Getintopc ensures that you have access to all the features and benefits of the website. Some software or premium content may require a password to access, so having a strong password ensures that you can take advantage of everything the site has to offer.
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Using a Getintopc properly is essential to maintaining the security of your account and personal information. Here are some tips on how to use your Getintopc password properly:
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- Use a password manager: If you have trouble remembering your password, consider using a password manager to securely store your passwords.
In conclusion, a Getintopc password is an essential component of maintaining the security of your account and personal information on the website. By using a strong password and following best practices for password security, you can ensure that your account remains safe and secure.


The Venezuelan government has officially launched the pre-sale of its controversial "petro" token, according to a report.
The petro was first announced in early December 2017 by President Nicolas Maduro as a way to circumvent U.S. sanctions, amid an economic crisis and a plunge in the value of the bolivar. The token is said to be backed by commodities, including oil, of which the country has notable reserves.
According to Latin American news source Telesur, 82.4 million tokens are available initially. The president has previously said that 100 million petros will be issued, valued at over $6 billion.
President Maduro was quoted as saying in a launch announcement:
"Petro is born and we are going to have a total success for the welfare of Venezuela. ... The largest and most important companies and blockchain in the world are with Venezuela, we are going to sign agreements."
A "manual" setting out how to acquire the petro will now be available in several languages, Telesur states.
The official in charge of managing the token, Carlos Vargas, reportedly said the pre-sale and initial offering will be exchangeable for "hard currencies" and cryptocurrencies, but not the comestic fiat currency, the bolivar.
While it might make sense for a cash-strapped country to try and bring in new funding via such a token sale, the petro has been controversial from the get-go.
Venezuela's opposition-run congress declared soon after it was announced that the petro would be illegal. The legislative body argued that the issuance would effectively be borrowing against the country's oil reserves, thus violating laws setting out that congress must approve government borrowing.
Saying the scheme was "tailor-made for corruption," legislator Jorge Millan said, "This is not a cryptocurrency, this is a forward sale of Venezuelan oil."
In late January, U.S. Senators Marco Rubio (R.-Fl) and Robert Menendez (D.-NJ) also denounced the planned cryptocurrency in an open letter addressed to U.S. Treasury Secretary Steven Mnuchin.
Rubio and Menendez wrote at the time: "It is imperative that the U.S. Treasury Department is equipped with tools and enforcement mechanisms to combat the use of cryptocurrency to evade U.S. sanctions in general, and in this case in particular."
According to CNBC, Harry Colvin, director and senior economist at Longview Economics, expressed doubts about the potential success of the petro scheme.
"Venezuela has been known for misappropriation of assets in the past and the central bank has just created hyperinflation so I imagine there'll be trust and transparency issues," he told the news source.
Furthermore, should President Maduro lose the election in April, "then petros would probably be made illegitimate," he added.
Edit: This article was updated at 11:15 UTC to include additional comment.
National Assembly Building image via Shutterstock
The leader in blockchain news, CoinDesk is an independent media outlet that strives for the highest journalistic standards and abides by a strict set of editorial policies. Have breaking news or a story tip to send to our journalists? Contact us at email@example.com.
Australia Warns of Fake 'Tax Collectors' Demanding Bitcoin
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Bitcoin briefly falls below $8,000 after Google says it will ban cryptocurrency ads
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Social media users re
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Congressional hearing on cryptocurrencies devolves into bitcoin bash fest
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Square closes near all-time high after analyst compares stock to early days of Amazon
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Brazilian Officials Caught Using Bitcoin in $22 Million Scam
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text:
a EK (Pce dispertab 500 mg)
Generic Name: erythromycin
Pill imprint a EK has been identified as Pce dispertab 500 mg.
PCE Dispertab is used in the treatment of strep throat; skin infection; chlamydia infection; dental abscess; bronchitis (and more), and belongs to the drug class macrolides. There is no proven risk in humans during pregnancy. PCE Dispertab 500 mg is not subject to the Controlled Substances Act.
See also related documents.
Images for a EK (Pce dispertab 500 mg)
- Generic Name:
- 500 mg
- Elliptical / Oval
- Prescription only
- Drug Class:
- Pregnancy Category:
- B - No proven risk in humans
- CSA Schedule:
- N - Not a controlled drug
- Abbott Laboratories
- National Drug Code (NDC):
|NDC Code||Manufacturer / Repackager|
|55289-0027||PDRX Pharmaceuticals Inc (repackager)|
|54868-1774||Physicians Total Care Inc (repackager)|
Note: Inactive ingredients may vary.


Pydiction consists of a Vim plugin and a Python script that allows programmers to tab-complete their Python code in Vim by generating a dictionary file of Python modules, and their attributes and methods. It comes with a default dictionary containing the entire Python standard library, keywords, built-ins, and many 3rd-party modules like Numpy, Django, Flask, Requests, Twisted, PyQT4, Pygame, OpenGL, wxPython, PyGTK, MySQLdb, Psycopg2, and more.
MAPDAV (More Accurate Password Dictionary Attack Vector) is designed to use what is known about users via the /etc/passwd file on Unix/Linux systems to generate a dynamic dictionary of more accurate guesses as to what their possible password may be. It does this by mangling the user's username and user information in various user-specified ways to look for bad password protection practices.
The Exquisite `df' (xdf) is a souped-up version of df(1) rewritten from scratch and focused on flexibility of field selection and output format. It offers HTML and CSV outputs, besides the traditional text-based console output. It is fit for system administrators who are tired of post-processing df(1) output through shell or Perl scripts in order to avoid broken lines or to get a simple total/summary line.
Gpart is a small tool which tries to guess which partitions are on a PC harddisk in case the primary partition table was damaged. It works by scanning through the device (or file) given on the commandline on a sector basis. Each guessing module is asked if it thinks a filesystem it knows about could start at a given sector. Several filesystem guessing modules are built in, and others can be added dynamically.