text:
A conversation with Jim White, MD, PhD, a Pulmonologist from the University of Rochester Medical Center
As the medical director of the Pulmonary Hypertension Program at the University of Rochester Medical Center (URMC) – a nationally accredited pulmonary arterial hypertension (PAH) comprehensive care center – Jim White, MD, PhD treats patients and conducts a wide variety of clinical trials, with a particular focus on PAH. White recently published a study in the Journal of Heart and Lung Transplantation that provides definitive proof that utilizing risk scores directly associates with predicting clinical outcomes in patients with PAH.
White describes the impact this study can have on physicians’ practice, and how it can improve patient outcomes.
Why is this study so important for pulmonologists?
There are two main reasons that I'm excited to share this paper with peers in my field.
Number one: this is by far the best evidence to date that using a formalized risk score directly associates with patient outcomes in PAH. This study is proof of that association. Our study is the first time there has been a large, long-term, randomized and controlled study that showed convincingly that a change in risk scores can predict outcomes, whether for better or for worse. This is the best evidence in our field that using risk scores ensures our patients are improving in formal, measurable ways. There is evidence to suggest that not a lot of physicians are using risk scores in their practice, and this study could potentially change how people practice.
Number two: this is a step toward risk scores becoming a part of how we test new drug therapies, which can increase both the pace and efficiency of drug development. Our study is moving the field toward a time when we don't have to put patients on placebos for years to determine if a drug works or not. This would be such a relief for our patients. It can also make trials less expensive because we have more opportunity to develop drugs through shorter trials. This could potentially mean new therapies that otherwise wouldn’t come to market.
How do risk scores work? How often do you assess them?
There are several different types of risk scores that can be used: COMPERA, REVEAL 2.0, and REVEAL Lite 2. Each one is described in our paper, and all are perfectly acceptable to use even if they have some differences. There are three key components to a risk score: 1) NT-proBNP level, a hormone produced by the heart that can be assessed through a blood test, 2) some measure of exercise tolerance, and 3) functional class and measurement of symptoms. The different types of risk scores may have other different components, but you add them all together to get the overall risk score.
What I’m encouraging physicians to do is to pick a risk score type and calculate it with your patient on a regular basis, every 3 to 6 months. Epic has tools to do this, you can easily incorporate risk scores in your electronic medical records. If you show that treatment you prescribed has improved that risk score, you can be confident that patients will do better in the long-term, namely less hospitalization, less death. Regular usage of risk scores should become a formal part of practice.
Which risk score do you use at URMC? Why?
We use REVEAL Lite 2. It’s one of the more difficult ones to use because there are a lot of components, but it results in the most precise predictions, whether things are going well or not well. The simpler tools still work too though! All are effective at predicting clinical outcomes, but I prefer the robustness of REVEAL Lite 2.
How have you seen this play out with your patients? Has it changed your interactions?
Many doctors already review components of risk scores with their patients, but aren’t routinely testing for exercise tolerance or testing for the NT-proBNP needed to calculate a risk score. You really need to be assessing these variables on a regular basis until your patient is low risk so you can stay ahead of the assessment.
In some cases, a patient may say “I’m feeling better,” and that’s the end of the story. A physician might not calculate risk score after that point. This is where a change in practice is needed, by consistently getting that risk score until the patient is at a point where you believe they are at the lowest risk they can achieve.
# # #
Read the full study here: “Contemporary risk scores predict clinical worsening in pulmonary arterial hypertension - An analysis of FREEDOM-EV”
The Journal of Heart and Lung Transplantation invited White to speak about his work on JHLT: The Podcast (November 2022).
This study drew heavily from a 2019 study, also authored by White, published in the American Journal of Respiratory and Critical Care Medicine, “Combination Therapy with Oral Treprostinil for Pulmonary Arterial Hypertension. A Double-Blind Placebo-controlled Clinical Trial”

domain: medical


text:
Deco City Motor Lodge
308 Kennedy Road, 4110 Napier, New Zealand – Great location - show map
|Studio - Disability Access|
|× 6||Two-Bedroom Apartment|
5 Reasons to Choose Deco City Motor Lodge
Manage your bookings online
The staff speaks English
Booking is safe
- Outdoor Pool (seasonal)
- BBQ Facilities
Pets are not allowed.
- Bikes Available (free)
Food & Drink
- Snack Bar
- Breakfast in the Room
WiFi is available in all areas and charges apply.
Free! Free private parking is available on site (reservation is not needed).
Front Desk Services
- ATM On Site
- Baggage Storage
- Tour Desk
Entertainment & Family Services
- Babysitting/Child Services
- Daily Housekeeping
- Ironing Service
- Dry Cleaning
- Business Center
- Paid WiFi
- Airport Shuttle (surcharge)
- Designated Smoking Area
- All Spaces Non-Smoking (public and private)
- Packed Lunches
- Soundproof Rooms
- Family Rooms
- Facilities for Disabled Guests
- Airport Shuttle
- Non-smoking Rooms
- Room Service
What would you like to know?No thanks
Thank you for your time
Your feedback will help us improve this feature for all of our customersClose
We're sorry, but there was an error submitting your comment. Please try again.Retry
Area Info – Great location - show map
- McLean Park 1.5 miles
- Mission Estate Winery 2.3 miles
- Pania of the Reef Statue 2.3 miles
- Church Road Winery 2.4 miles
- Bluff Hill Lookout 2.7 miles
Most Popular Landmarks
- Elephant Hill Wine Estate 8.6 miles
- Splash Planet 9.4 miles
- Trinity Hill 10.9 miles
- Te Mata Estate 11.1 miles
- Black Barn Vineyards 11.3 miles
From 2:00 PM
Until 10:00 AM
Cancellation and prepayment policies vary according to room type. Please enter the dates of your stay and check what conditions apply to your preferred room.
Children and Extra Beds
All children are welcome.
All children under 2 years stay free of charge when using existing beds.
One child under 2 years stays free of charge in a crib.
All older children or adults are charged NZD 20 per person per night when using existing beds.
One older child or adult is charged NZD 20 per person per night in an extra bed.
The maximum number of extra beds/cribs in a room is 1.
Any type of extra bed or crib is upon request and needs to be confirmed by management.
Additional fees are not calculated automatically in the total cost and will have to be paid for separately during your stay.
Pets are not allowed.
When booking more than 4 rooms, different policies and additional supplements may apply.
Cards accepted at this property
Hover over the cards for more info.
100% Verified Reviews
Real guests. Real stays. Real opinions.
Based on 445 reviews
Good: 7 – 9
Okay: 5 – 7
Poor: 3 – 5
Very Poor: 1 – 3
Value for money
Show reviews from:

domain: travel


"Adapting to Climate Change: Sustainable Construction Techniques for the Future" examines the construction industry's shift towards sustainability in response to climate change. It highlights the use of eco-friendly materials, energy efficiency, water conservation, and resilience against extreme weather. The blog emphasizes the importance of integrating renewable energy, leveraging technology like BIM and IoT, and adhering to regulatory standards for sustainable construction. The aim is to mitigate environmental impact, ensure building longevity, and embrace regulatory compliance, offering a blueprint for future construction practices.
"Effective Project Management Strategies for Construction Leaders" provides an in-depth look at optimizing construction projects through strategic planning, risk management, and the integration of cutting-edge technologies. Emphasizing the importance of communication, continuous learning, and sustainable practices, this blog guides construction professionals on enhancing efficiency, safety, and quality control. Highlighting keywords such as "construction project management," "risk management in construction," and "construction technology trends," it offers actionable insights for leaders aiming to steer their projects toward success and sustainability in the competitive construction industry.


The other day I got a Knook from my friends at Leisure Arts and, even though I already knit, I did find it pretty innovative especially for crocheters who will never abandon their hook for a knitting needle. For all those crocheters out there who don’t knit but would like to – and there are a lot – the Knook is just the thing.
A few tips:
1. Be sure to do a swatch large enough so you’re comfortable with the technique before you do a swatch for the garment or project you plan to make.
2. Be sure to follow the instructions as they are written or you could get a few twisted stitches as I did (on the third row down from the stitches on the hook):
So enjoy Knooking – a real stitching treat!


text:
The US government declared a state of emergency on Sunday in a bid to keep fuel supply lines open as fears of shortages rose following the shutdown of a major pipeline.
The move lifted various limits on the transport of fuels by road to ease the fallout from the continuing closure of the Colonial pipeline, which carries almost half the fuel consumed on the US East Coast, following a ransomware cyber attack on Friday.
“This Declaration addresses the emergency conditions creating a need for immediate transportation of gasoline, diesel, jet fuel, and other refined petroleum products and provides necessary relief,” the Department of Transportation said.
The pipeline’s operator, the Colonial Pipeline Company, was forced to take the entire system offline on Friday after an attack it attributed to ransomware, whereby hackers seize control of a victim’s computer systems or data by installing illicit software, and only release the assets once payment is made.
It said on Sunday evening that its main lines remained offline, but that some smaller lines between terminals and delivery points had been returned to service. It gave no indication as to when full service would resume.
“We are in the process of restoring service to other laterals and will bring our full system back online only when we believe it is safe to do so, and in full compliance with the approval of all federal regulations,” the company said.
Petrol prices jumped by as much 4 per cent as trading reopened on Sunday evening, before falling back to trade around 2 per cent higher on the day at $2.16 a gallon.
If the pipeline was not quickly reopened the impact on prices could become more severe in the coming days, said Patrick De Haan, head of petroleum analysis at data provider GasBuddy.
The pipeline is the country’s biggest conduit for refined products, spanning more than 5,500 miles from Pasadena, Texas to Linden, New Jersey and New York Harbor. It serves some of the US’s transport hubs, including the country’s busiest airport, Hartsfield-Jackson in Atlanta.
Gasoline demand in areas served by the pipeline rose by about 4 per cent on Saturday compared with the previous week, according to GasBuddy, indicating a degree of panic buying as consumers fretted over the potential for a prolonged outage.
The shutdown may trigger another rise in US petroleum imports, exposing the country’s energy vulnerability despite a decade of soaring domestic and gas production.
“The base case is that it’s resolved quickly, but if not US gasoline and diesel prices will have to rise very significantly to draw in sufficient imports from Europe,” said Robert Campbell, head of oil products research at consultancy Energy Aspects.
Refiners in the US Gulf Coast that use the pipeline to ship products eastward would be forced to trim back fuel production, he said.
Large pipelines increasingly rely on automation to monitor flows and pressure, and control batches of deliveries of petroleum products, increasing the disruption that can be caused by a computer hack.
“This is definitely not a schoolboy prank. This is a highly sophisticated attack on a piece of critical infrastructure,” said Campbell.
The attack comes amid growing concerns about cyber security vulnerabilities in America’s critical infrastructure after last year’s SolarWinds attack, which has been attributed by US authorities to Russia.
It also comes as ransomware attacks have proliferated in recent years, with cyber criminals — often operating from jurisdictions where they will not be prosecuted by authorities — making average ransom demands to victims of more than $100,000, according to the US Department of Justice.
Last month, a coalition of big tech companies and US officials from the FBI and DoJ called for governments to designate ransomware a national security threat and to “exert pressure” on nations that refuse to join efforts to tackle the hacking epidemic, for example through sanctions.
The attack came as the White House was preparing for another round of negotiations with legislators about the president’s proposed $2.3tn infrastructure package.
Biden and the Democrats say unprecedented federal spending levels on everything from broadband access to subsidised childcare are needed to help propel and sustain an economic recovery. But Republicans have pushed for a slimmed-down bill more tightly focused on traditional infrastructure projects, such as roads, bridges and tunnels.
Adam Kinzinger, a Republican congressman from Illinois, on Sunday said the attack on the Colonial pipeline underscored the importance of investing in critical infrastructure and energy projects.
“This needs to redouble our efforts as a country to get past our internal divisions . . . and focus on things like critical infrastructure in the future,” he told CBS News. “Because this is only going to continue to happen more often if we’re not careful.”

domain: news


text:
Nik Vucevic's reaction said it all.
As the final tenths of a second ticked off the clock Sunday night, Vucevic took a few dribbles and hurled the basketball skyward. The fans inside Amway Center, almost all of them standing, yelled and shouted their approval.
The Orlando Magic had won a game they weren't supposed to win and stunned the Indiana Pacers 93-92.
"It was the way we won," Vucevic said, a smile on his face. "It was a great team win."
Tough to argue with that.
The Pacers, the team with the NBA's best record and best defense, held a 17-point lead late in the third quarter, but the Magic — led primarily by rookie Victor Oladipo and their second unit — recovered and recorded a shocking victory.
"We play hard," Oladipo said. "It might sound simple and it might sound just kind of plain, but that's really what it is. We just played harder today."
Less than 48 hours earlier, on Friday night, the Magic bounced back from a 17-point deficit in the second quarter to beat the team with the league's second-best record, the Oklahoma City Thunder, 103-102.
In both of those wins, the Magic received a boost from their bench, especially Oladipo.
On Sunday, the rookie scored a team-high 23 points — including seven consecutive points during a key stretch from late in the third quarter to early in the fourth quarter.
"He is special," Pacers All-Star wing Paul George said.
George is special, too.
He finished with a game-high 27 points, and he gave the Magic players, coaches and fans a fit of worry during the game's final seconds.
Clinging to a one-point lead with 9.0 seconds left, the Magic had to inbound the ball from halfcourt.
Vucevic, standing on the sideline with the ball, thought he was close to committing a five-second violation. Without any timeouts remaining, Vucevic tried to throw the ball off of David West's right leg, but the ball went between West's legs and bounced high off of Amway Center's parquet floor.
The ball wound up in George's hands, and George dribbled the ball down the court and attempted a 20-foot jumper.
Vucevic and Glen Davis contested the shot, and Arron Afflalo stood nearby, too.
George's heave fell short.
"Everybody was running hard and didn't want to give up an easy bucket," Oladipo said. "Three people contested Paul George's shot! Three people!"
George thought Davis had fouled him, but the referees didn't oblige.
Oladipo swatted the ball toward the perimeter, and Vucevic caught it and started dribbling.
The Magic (16-37) now have won their last five games at Amway Center.
Inside their postgame locker room, the Pacers (39-11) sensed they missed an opportunity to widen their lead over the Miami Heat in the Eastern Conference standings.
"We had this game," West said. "They played harder. They were the more sound team down the stretch."
Maurice Harkless, a second-year wing, spent much of the fourth quarter guarding George, and George made just two of his five shot attempts in the quarter.
"It's just trust and confidence that's growing inside of us, especially the young players," Davis said. "I think that's a big thing. They're helping out tremendously. Moe, Tobias [Harris] and Kyle [O'Quinn] have been playing really, really great."
The Magic outrebounded the Pacers, scored more second-chance points than the Pacers and outscored the taller Pacers in the paint.
"In my eyes," Magic point guard Jameer Nelson said, "we outworked them, especially in the second half. Everybody who played and even the guys on the bench did their job of keeping guys' heads into the game and rooting guys on as they were out there battling."
email@example.com. Read his blog at OrlandoSentinel.com/magicblog and follow him on Twitter at @JoshuaBRobbins.


text:
Another Country Pottery
A Trivet made of black clay similar to that of the Pinch Pot and (black) Pitcher, and not glazed.
The Another Country Pottery Series is a collection of handmade tabletop pottery that employs different clay bodies with different properties for each vessel and use. The clay shapes are pressed and then fettled, dipped in glaze, fired and polished.
The range drew inspiration from the Series One furniture collection and its surfaces are either left unglazed or clear glazed to reflect – as with our furniture collections – the true colour of the material.
Our mission is to be a responsible, purposeful and useful company that is fit for the 21st century, and our ambition is to sell our sustainably made furniture to as many people as possible.
To do this, we strive to strike the right balance between craft and industry.
Visit our showrooms
At both our London and Dorset showroom you will find a broad selection of our furniture designs on display alongside a curated edit of home accessories. For showroom opening hours click here. To book a virtual visit click here, or call us on +44 (0)20 7486 3251 for London or +44 (0)1747 445 695 for Dorset.
Eligible for Return within 14 Days
Free UK Delivery Over £1500

domain: design


text:
What is property? In basic terms, property is land, structures, and natural deposits (water, minerals, and crops) – and unmovable property. A person who owns realty has an interest in the land, structures, or housing. It can be used as a income or to purchase brand-new building. It can also be an financial investment car for structure businesses and other tasks. It’s a terrific way to begin in buying real estate, and many people utilize it as a method to accomplish monetary freedom.
There are lots of rewards to working with a property representative such as realtors kelowna. For beginners, they have a wealth of knowledge of the location in which they live, and are familiar with regional property values. They can offer ideas on how to price your home properly and assist you avoid making pricey mistakes. They can even tell you whether a particular residential or commercial property is overpriced or underpriced – and that can save you from unneeded tension. A real estate agent can help you find a house within your spending plan, and make the process go as efficiently as possible.
There are numerous kinds of realty. A sale of vacant land is a excellent way to get into the marketplace if you’re searching for a large home or a farm. Uninhabited land may include natural deposits and is usually priced in the 10s of thousands of dollars. It is a excellent alternative for financiers who are looking for a 2nd home, or a weekend trip. In addition to selling a residential or commercial property, buyers can also get a loan to fund the purchase.
Uninhabited land, on the other hand, is the least industrialized home and can vary from farmland to cattle ranches. It might contain water or natural deposits, but the expense will be less than the earnings of one effective offer. In addition to being an possession for investment, real estate investing can help you diversify your portfolio and minimize threat. There are numerous benefits to buying realty. Just remember to stay thorough and familiar with modifications in the market.
Vacant land is the most pricey type of realty. This type of property generally is not used for any function, so the worth of it depends upon the owner. Normally, however, the cost of uninhabited land is the same as the expense of a single developed unit. The cost of a single house might deserve a couple of hundred dollars, while a industrial property might cost 10s of countless dollars. It is for that reason important to consider how much money you can invest in the various types of property prior to purchasing a home.
In realty, the price of a property is determined by its use. A home’s value can not be higher than its sales price. The greatest and finest use will produce the most income. Similarly, a home’s worth can not be higher than that of a similar residential or commercial property. These elements are the primary aspects that figure out the value of a home. The following factors will impact the rate of a home. These include the location, amenities, and availability.
A property’s worth increases with its conformity and contribution. A function can add worth to a home. The higher its use, the better it is. The greater the need, the more valuable a residential or commercial property is. It can be miscalculated, but the best use will produce the greatest revenue. When a home is listed on the market, it should be competitive. It must also be priced listed below its equivalents in the area.
Real estate is a type of property. It can be either unaltered or improved. It can be owned by a government, business entity, or private celebration. The most vital classification is brand-new home structure, that includes single-family houses, townhouses, and condos. The National Association of House Builders publishes month-to-month information on the variety of new house sales, and the cost of these homes. This fact is a leading indicator for a real estate economy, and it can be deceptive.
When determining what type of home is best for you, think about the worth of the property. A property’s worth can be more than doubled if it is a brand-new advancement. Sometimes, the land is unimproved and the developer has actually currently started construction. The price of a residential or commercial property is higher when it is more industrialized than a formerly unsold one. A home is not always worth more than its present market value.

domain: finance


Mold Repair Laser Marking
Deep Engraving Mold Cavities
LaserStar's laser marking and engraving systems are a fast, clean technology that are rapidly replacing older laser technologies and traditional methods of engraving. Fiber laser technology offer various methods for permanent laser marking and engraving and can be used in many applications in the Tool & Die and Mold Making Industries. Most metals, plastics and some ceramics can be lettered, marked or permanently engraved with these systems.
Alphanumeric characters, graphics, logos, bar codes, etc. can easily be applied using laser marking machines and are widely used in industrial markets and tool manufacturing. As laser technology evolves, laser markers have become more precise and useful for an increasing number of applications on a wide range of component parts.
Laser marking and/or engraving is a computer-driven, environmentally friendly alternative to mechanical engraving, chemical etching, milling, and many other costly, lower quality processes. In recent years, laser marking technology has proven to be a viable source for mold repair marking & engraving as many traditional engraving methods have failed to meet the continually growing standards for precision, depth, and quality. Alpha-numeric character sets or images are etched on various material surfaces, such as stainless steel, graphite, aluminum, and copper while providing high quality engravings.


text:
Elkhorn soccer pulls away from Parker in final half
Elkhorn pulled away with four goals in the second half en route to a 6-0 nonconference win over Janesville Parker in girls soccer Tuesday night.
Parker (0-2) trailed 2-0 at half but could not generate any offense.
"We were coming off spring break, and so some of our girls were tired," Parker coach Amy Wargowsky said.
"Every game is a learning experience for us. We have to build on any postives and work on the negatives."
Parker opens Big Eight Conference play Thursday night at Madison Memorial.
ELKHORN 6, PARKER 0
Janesville Parker 0 0—0
Elkhorn 2 4—6
E—Elise Gorecki (Katelyn Daehn), 8:55. E—Gorecki, 32:25.
E—Daehn, 40:41. E—Jessica Hauser (Teresa Middleton), 63:26. E—Gorecki (penalty kick), 69:01. E—Daehn (Jessica Nehs), 74:54.
Saves—Brianna Washington (P) 8, Elkhorn 3.
Last updated: 8:10 pm Thursday, December 13, 2012

domain: sports


text:
I've never had a good experience here...too many young kids not knowing what they are doing. Advertised as multiple soft serve flavors available, but when you go in mysteriously the machine is "not working". Getting fried food you can taste the oil is old and doesn't frequently get changed....along with other foods being fried in the same oil.
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.

domain: food


Last week, Heart was honored as the latest recipient of a star on the Hollywood Walk of Fame. So, in recognition of their award, I felt like they would be the perfect band for this week's Music Monday. I guess it's The Sheepdog's way of offering his congratulations to the band.
Today's appearance is Heart's fifth on this blog. Currently, they trail only Queensryche for most appearances here. Heart is definitely one of my favorite bands, and the song and video I'm highlighting today is "Never" from their self-titled album released in 1985. The video is embedded below, as usual, or can be watched by clicking here. Enjoy everybody.


The CZ 83/82 are great little guns. Find a 82 in good shape, they are the military version, shoots 9x18mm. The 82 is the same gun without the southpaw safety but better priced. Just a note, the 82 has a polygonal rifled chrome lined barrel. I have a CZ-75B and CZ-82, I can CC the 75 but carry the 82 most of the time now days. CZ makes the best of guns, IMO.


text:
Both the U.S. and the Mexican Under -20 national teams had advanced to the semi-finals of the CONCACAF U-20 Championships taking place in Puebla, Mexico. The U.S. defeated Canada 4-2 on Tuesday evening while Mexico beat Jamaica 4-0 last night.
The team that represents the Stars and Stripes will face Cuba, while "El Tri" will face Panama on Friday afternoon/evening. The U.S. will play at 4:00pm local time, while Mexico will play at 7:00pm local time. Both games will be televised on FOX Soccer Channel.
It is important for both national teams to not overlook the their opponents in the semi-final round looking forward to the logical final round that everybody wants between Mexico and the United States.
Cuba is the biggest surprise of these championships showing a lot of offensive punch looking very strong. Panama has has been getting better with every match under their belt in this tournament. However, if both the Americans and Mexicans execute their assignments on the pitch victories should be acquired.
The final will take place on Sunday, also televised by Fox Soccer Channel.


text:
We were Livestreaming the other night. Thanks to everyone that checked it out. Here is the recording of the work on the Campaign Editor that was done. Leave us a comment about what you think!
Do you remember that impossible game we put out and promoted on Newgrounds.com on April Fools Day? Yeah...that one! Well we put together a video of some of the reviews people left!
Read our previous blog on the prank also, by clicking here!
In this update we show you how we tweak/cut/mix the dialog audio to create a more immersive experience. What did you guys think of the Road of the Dead 1 audio & dialog? Be sure to check out the previous Road of the Dead 2 development posts here.

domain: entertainment


text:
ISLAMABAD, Feb 1 (Pakistan Point News - APP - 01st Feb, 2017 ) : The World Bank Country Director, Patchamuthu Illangovan Wednesday said the bank's Chief Executive Officer CEO) Kristalina Georgieva was impressed by the Pakistan government's efforts to strengthen prospects of inclusive growth. During a meeting with Finance Minister Senator Mohammad Ishaq Dar here, he said the CEO was particularly encouraged by the government's focus on energy reforms, financial inclusion, human development and social services.
Illangovan thanked the finance minister for extending hospitality to Kristalina Georgieva, during her recent visit to Pakistan, said a Finance Ministry press statement. He conveyed the CEO's appreciation to the minister and highlighted that the trip had provided her an opportunity to witness first-hand, the progress Pakistan had made in different sectors. He said that she was particularly impressed to see the Tarbela Hydropower Expansion Project, restoration of historic Walled City in Lahore and Sindh education Programme. The Finance Minister expressed his best wishes for the CEO and appreciated the cooperation and support extended by the World Bank to the Government of Pakistan in achieving the objectives of socio-economic development.