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domain: finance


Like many enthusiasts, Burt Rutan draws strange-looking aircraft; but he builds them and they work – well. The “Quickie” was designed in 1977 by Rutan, T. Jewett and G. Sheehan.
It has a foam core covered in glass fibre and weighs only 250 lbs. The innovative “canard” layout (tail first) makes it stall-proof.
The engine is a 25 hp Onan built to power lawnmowers. Our example was built in Victoria in 1978 by Fran Benton, and was donated to the Museum in 1995.


The phenomenally talented Nigerian singer-songwriter and performer known as Kaestyle makes his musical debut with the incredible jam “Wiser.”
From Rivers state, Kaestyle—previously known as Kaystyle—is a singer, songwriter, and music producer. He has been playing the game for some time, but he recently changed his identity. His first single under KeyQaad, titled Stamina, is about to be released.
Omah Lay was introduced by KeyQaad in 2019, and during the COVID in 2020, he emerged as the most popular new artist. Kaestyle, a talented young musician and performer from Port Harcourt, has now joined him.
Additionally, this unique song is a part of his recently discovered debut music collection, “Kae’s Study EP.”
Despite your best efforts to ignore this incredible music with its mind-blowing lyrics and sounds, you simply cannot resist it.
Listen and share your thought below:


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The Forex world is constantly evolving and during its weekly trading hours there is a wealth of news a trader must keep on top of if they want to make the most money possible. Indeed, because the market can be affected by a number of dynamics, it is essential they know exactly what’s happening at all times in order to avoid any unprofitable deals.
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Knowing the value of each currency based on various internal and external factors is crucial and the reason why FXBrokerSearch.com’s Forex news centre is a vital resource. Drawing on a number of resources, our information section provides the latest information and data from which users can refine their trading activity.
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China has ordered state firms to smash the decades-old system of providing cradle-to-grave welfare support, known as the country's "iron rice bowl". At the hear ..
Japanese workers put up with long hours and unpaid overtime under pressure from cost-saving companies, and figures from government, which wants more money in workers' poc ..
Nissan Motor Co , Renault SA (RENA.PA) and Mitsubishi Motors Corp (7211.T) will combine their electric vehicle platforms in an effort to slash prices down to levels comparable ..
Greece's decision to give pensioners a one-off bonus has delayed the conclusion of its second bailout review but an agreement can still be reached in the coming months, E ..
Some of the biggest foreign investment and commercial banks operating in Britain paid an average tax rate of just 6 percent on the billions of dollars of profits they made in ..
Benchmark U.S. stock index rallies, in anticipation of fiscal stimulus measures by the incoming administration of President-elect Donald Trump, could also be laying the seeds ..
Goldman Sachs Group Inc has agreed to pay $56.5 million to resolve a U.S. class action lawsuit accusing it and other banks of rigging an interest rate benchmark used in the $5 ..
The stock was the biggest drag on the S&P and the tech sector. The Dow Jones industrial average fell 8.83 points, or 0.04 percent, to 19,843.41, the S&P 500 lost 3.96 ..
The U.S. dollar edged lower against a basket of major currencies on Friday, but still held near 14-year highs touched after Wednesday's Federal Reserve meeting, with prof ..
Chipotle Mexican Grill Inc , under pressure from activist investor Bill Ackman, named four new board members on Friday, paving the way for a reunion of sorts between its chief ..
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Chamonix and Zermatt, the two capitals of the Alps. The history of alpinism has written its most famous pages there. Both Mont-Blanc range and Wallis Alps gather 69 4000-meter summits out of a total of 82 in the entire Alps Mountains. Spectacular views, strong local cultures, a rich history, … are waiting for you to enjoy.
Our alpine trek starts from the well-known mountain resort of Chamonix, and travels over mountain passes, through eight valleys of the Swiss Wallis region, using trails and rugged terrain, with landscapes varying from lush green alpine pastures to jagged rocky landscapes. Each day several 4000 meter peaks come into view : Grand Combin, Dent Blanche, Zinalrothorn, Weisshorn, the Matterhorn ... The complexity of the route - along glaciers and lakes, through alpine pastures and villages - makes this trek one of the greatest of the kind in the Alps.
A demanding trek, with long daily hikes, high mountain passes, for which we recommend to prepare yourself quite seriously !
In order to immerse ourselves into a unique alpine setting, we carry all our belongings for the week. Nights in dormitory, in mountain inns or huts. We use public transportation for transfers and get food supplies from villages or from the huts.
Day 1 : Chamonix – Col de Balme Elevation gain: 900m Vertical loss 1000m
Our hiking adventure starts from the village of Le Tour. Once at Col de Balme, our first hiking goal, we will say goodbye to the king of the Alps, Mont Blanc, and the nearby needles, and discover the Swiss Alps and pastures. We follow the trail down to Alpages des Grands and lower down to the Trient glacier creek. Col de la Forclaz and our hotel are only 2 miles away.
Day 2 : Croix de Bovine – Champex – La Fouly Elevation gain: 1000m Vertical loss 1000m
As we hike up to the alpine pastures of La Giète, the Swiss Herens cow breed welcomes our arrival with a typical cowbell melody. While we leave behind us the busy cheese maker, the trail leads to Croix de Bovine. There the panorama rewards our efforts with an incredible view over the upper Rhone valley. The Bernese Oberland and the Penian Mountains border the Swiss Wallis region. It is time to hike down to the charming alpine village of Champex, where we stay for the night.
Day 3 : Verbier - Cabane de Louvie Elevation gain: 400m Vertical loss 400m
After a transfer to Le Châble, we take a gondola to the top of Verbier resort. We startour hike on the "Chamois Trail", a panoramic traverse facing the Combins mountain range. The views on Val de Bagnes and the gigantic Corbassière Glacier are just spectacular. After Col Termin, we hike down to Louvie hut sitting by the emerald lake of Louvie.
Day 4 : Cabane de Louvie - Cabane de Prafleuri Elevation gain: 940m Vertical loss 560m
Our trail follows old alpine pastures, where chamois and ibexes enjoy grazing the lush mountain grass, hardly accessible to cattle. Then, the trail winds up and across rather steep and rocky slopes, to reach a first mountain pass : Louvie. From there, the terrain is rugged and rocky, and glacier moraines and creeks leave little room to
alpine vegetation. We hike across “Grand Desert” to reach Prafleuri Pass. On a clear day we can see Pigned’Arolla and Dent Blanche, part of our next day hike. Today ends with a descent to Prafleuri hut, where we enjoy a well-deserved sleep in a comfortable dormitory. This part of the trip is not very technical, yet it is long and demanding.
Day 5 : Cabane de Prafleuri - Arolla Elevation gain: 735m Vertical loss 1360m The day starts with a warm-up hike to the Roux Pass. After enjoying a magnificent view over Lac des Dix, we hike across the Barma alpine pastures and along the lake to reach its far end. From there we hike over “Pas du Chat” to set our feet on the other bank of the glacier creek, and start our long climb to Riedmatten Pass, following the moraine of the Cheilon glacier. As we hike up we can admire Mont-Blanc de Cheilon, and from the top of the Pass - weather permitting of course - we should get a glimpse of the summit of the Matterhorn. On the way down the chaotic Tsijiorne Nouve glacier and Mont Colon slowly come into view. This extraordinary day ends in the village of Arolla.
Day 6 : Arolla - Zinal Elevation gain: 1450m Vertical loss 920m
A taxi takes us to Le Cotter, above the village of Les Haudères. The climb up to Torrent Pass is pleasant and not too steep. It is in picture postcard scenery that the trail descends towards Moiry Lake through the meadows, with the Dent Blanche as décor. The Dent Blanche appears in the distance with lush alpine pastures in the foreground. To get to Zinal, we still need to hike over Sorebois Pass. This pass rewards us with an unforgettable
view of the surrounding 4000m peaks : Bishorn, Weisshorn, Zinalrothorn, Obergabelhorn. We hike down into Val d’Anniviers. We stay in a small hotel in Zinal.
Day 7 : Zinal - Grüben Elevation gain: 1220m Vertical loss 1050m
After a steep hike into a superb larch and spruce forest, we quickly gain altitude to admire the Dent Blanche again, and later on the Ober Gabelhorn. We leave the French speaking part of the Wallis region behind us, to enter the German speaking area as we hike over the Forcletta Pass. Local names are different but the views are equally beautiful : the Bishorn and the Weisshorn, the Brunegg and Turtman glaciers. We finally reach the summer mountain hamlet of Grüben in the Turtman valley (Turtmantal), where we spend the night.
Day 8 : Grüben - Zermatt Elevation gain: 1070m Vertical loss 1790m
Although the last pass of the trip is quite hard to pronounce, the Augsbordpass is easy to hike to. During the long descent to St Niklaus looking down to Mattervispa valley, we stop at the alpine village of Jungu, and take a moment to admire the surrounding summits : the Weissmies, the Mischabel range with its many 4000m peaks (Dom, Täschhorn, etc...). From Jungu, we hike down an ancient Way of the Cross to the small town of St Niklaus. We reach Zermatt by train, where we spend the night.
Day 9 : Zermatt Elevation gain: 450m Vertical loss 450m
This last hike takes us to the hamlet of Zmutt, nested at the foot of the Matterhorn : a fantastic area to admire this legendary summit. Our trek ends in Zermatt, in early afternoon.
The guide may have to adapt the route to weather conditions and/or to group physical and/or technical ability.
More pictures on our blog : Chamonix-Zermatt par les sentiers
2018 DATE : From wednesday 01st to thursday 09th of august.
2018 PRICE : 1370€/person (for a minimum of 6 people)
The organization and supervision of each tour by State qualified trekking guide/s
Drinks and personal expenditure (souvenirs…)
Half-board accommodation in mountain hut, or basic hotel (dormitory)
Repatriation insurance (mandatory)
Transportation throughout the trek
|Shuttle back to Chamonix|| |
- ID or valid passport.
- Repatriation insurance (mandatory). Cancellation insurance is highly recommended.
We provide optional insurance contracts for repatriation and trip cancellation.
WHY CHOOSE COMPAGNIE DES GUIDES :
- An all-inclusive product
- Only 6 to 10 people per group and mountain leader
- Carefully selected accommodation
- Local products for our take-out lunches
Level : 5/5 See the hiking rating form.
The Chamonix to Zermatt - Hut to Hut is a strenuous and demanding trek. More than 1000m (3350ft) vertical
gain and about 7 to 9 hours of hiking daily. Some days may be long and demanding, involving altitude and high
mountain passes (min.2800m). Hiking on mountain trails and terrain showing exposed and difficult sections.
These trips generally require carrying a backpack with personal belongings throughout the trek. For expert
hikers only. For very active, well-trained people with a solid experience in alpine trekking.
GUIDING : Each mountain leader guides groups of 10 people maximum.
Important : no booking accepted in our scheduled groups for people under the age of 18 without a legal guardian.
ACCOMMODATION : 8 nights in mountain hut, or basic hotel (in dormitory or quadruple/triple room). Each hiker carries daily his personal belongings, and the picnic. Each hiker carries daily his personal belongings, and the picnic.
MEETING PLACE : At 8.30 am in front of the Compagnie des Guides de Chamonix on Day 1. You are welcome to come and meet your guide the evening before at our office at 6 pm.
EQUIPMENT : See attached list.
Note : Due to the elevation of the trek, a good equipment is strongly advised.
Repatriation insurance is mandatory. We strongly recommend the purchase of cancellation insurance.
Repatriation and cancellation insurance are available from our office.
TRAINING : Good physical condition will allow you to make the most of your holiday. A month before the hike at least, we suggest you walk upstairs, rather than use the elevator. During the weekends you can run, walk or ride your bike to train for the hike. Doing a medical check-up before signing for the trip is recommended. Your guide should be informed of any medical treatment.
CLIMATE : Alpine weather can change suddenly, involving wide temperature variations. Temperatures also drop with altitude, and snow falls in summer are not rare. A high pressure moving in can also bring in cool air. You should anyhow bring warm clothes and be prepared for cold or very hot weather, while minimizing additional weight gain.
Please, feel free to contact Anaïs the Compagnie des Guides for any further information.
You are a private group, you can ask for a customized trip, and have your own guide !
- Exclusive guide
A more individualized relationship between your group and the professional.
- Choose your date of departure
You can choose your date of departure within the limit of the hut availabilities.
- Flexibility all along the trip
Depending on weather conditions, your level and your expectations, the guide can suggest you some different options of itinerary.
For any further information, please contact Anaïs :
Tel : +33 450 53 00 88 or E-mail : firstname.lastname@example.org

domain: geography


Updated: Tue, 20 Sep 2022 02:19 PM IST
At least 4 people died while nine were admitted to hospital after a wall near Jal Vayu Vihar society in Noida Sector 21 collapsed on Tuesday.
NDRF and Fire Brigade teams are conducting the last search mission.
According to ANI, District Magistrate Suhas LY said a detailed investigation will be conducted to ascertain the cause of the wall collapse.
"We have received info of 2 deaths each (total 4) at District Hospital & Kailash Hospital, it is being verified. We're also ascertaining details on the injured."
#WATCH | UP: Rescue operations underway in Noida Sector 21 where a wall collapsed this morning.— ANI UP/Uttarakhand (@ANINewsUP) September 20, 2022
DM Suhas LY says, "We have received info of 2 deaths each (total 4) at District Hospital & Kailash Hospital, it is being verified. We're also ascertaining details on the injured." pic.twitter.com/FTXAVVvarm
The Noida Commissioner of Police, Alok Singh said that the FIR has been filed and action will be taken.
"Unfortunately, 4 people died. 9 people were shifted to a hospital for better treatment. NDRF and Fire Brigade teams are conducting the last search mission," Singh told to media persons.
Meanwhile, Uttar Pradesh Chief Minister Yogi Adityanath expresses grief over the loss of lives due to an incident of a wall collapse in Noida Sector 21. He has directed senior officials to reach the spot immediately and continue rescue operations on a war footing.
#UPCM @myogiadityanath ने जनपद गौतमबुद्धनगर में दीवार गिरने से हुई जनहानि पर गहरा शोक व्यक्त किया है।— CM Office, GoUP (@CMOfficeUP) September 20, 2022
मुख्यमंत्री जी ने वरिष्ठ अधिकारियों को मौके पर तत्काल पहुंचकर युद्धस्तर पर राहत कार्य संचालित करने के निर्देश दिए हैं।


World Cup star has been tipped to agree lucrative Arsenal deal as £52m offer revealed by source today –
Gabby Agbonlahor has tipped Bukayo Saka to sign a new contract at Arsenal and reject a move to Man City.
Speaking exclusively to Football Insider, the ex-Aston Villa and England attacker insisted Saka will be happy at Arsenal and will know his game time may be limited at Man City.
The 21-year-old has evolved into Arsenal’s main attacking threat but his long-term future is up in the air with his contract set to expire in the summer of 2024.
Sources told Football Insider last month (18 November) that the club have told key commercial partners that he is ready to sign a new deal.
The latest from an Arsenal source today is that the new contract will be worth around £52million in total and a full agreement will be reached soon.
It was reported last week (15 December) that Man City want to sign Saka and are closely monitoring his negotiations over a new deal.
“I think he will be happy with the club he’s at,” Agbonlahor told Football Insider correspondent Connor Whitley.
“It’s his club, he’s still young and they’re at the top of the league.
“He will look at Man City and think ‘I won’t start’. They’ve got Erling Haaland, Julian Alvarez, Phil Foden, Jack Grealish and Riyad Mahrez.
“He might look at it and think ‘I might not be a guaranteed starter’ but at Arsenal, he is.
“I think it’s a no-brainer, he signs a new contract at Arsenal.”
Saka has scored 28 goals and provided 35 assists in 151 games across all competitions for Arsenal.
The England star also found the net three times in four World Cup games before his side were knocked out at the quarter-final stage.
In other news, a finance guru has claimed that “big changes” are on the horizon for Man City amid a £167million agent reveal.


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Mr. Lowenberg has often been the featured speaker at seminars and conferences in the financial services industry and has advised law firms and accounting firms in charitable and estate planning, He has been a frequent guest on CNBS's Power Lunch and has been interviewed by Business Week as well. His writings have been published in numerous places including Forbes.com, Investment News, Austin Business Journal, Austin American Statesman, MarketWatch.com, MSN Money, SmartMoney and many more. Mr. Lowenberg's insights on "Making Your Charitable Donations Count—Five Tips in Choosing the Right Charity," were featured on MarketWatch.com. He is also a contributor to the book entitled Family Wealth Counseling—Getting to the Heart of the Matter by Mr. E.G. "Jay" Link, one of the foremost experts on issues and strategies relating to charitable planning techniques for wealthy families.
Mr. Lowenberg is a member of a number of industry organizations, including: the Association for Advanced Life Underwriters (AALU), the National Association of Insurance Financial Advisors (NAIFA) and The InternationalForum. Carlos is also Chariman of the Board of City Schools Austin and a member of the board of the Austin Lyric Opera.
Carlos and his family reside in Austin, Texas.


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today I am sharing with you this fun sketch I found looking for inspiration for a card or layout from:
I love the simplicity and versatility of this sketch and I hope you do too. This blog also host a sketch, if you decide to participate, please don't forget to mention that we are sending you ;-)
And let us know in your comment so we can also see your creations.
Please visit my page http://vickyscrappingpassion.blogspot.com
And Say hi.
And please don't forget the 41st Connie Can Crop Monthly Challenge!! This month the theme is:
Thank you for stopping by.

domain: design


Legislative Assembly for the ACT: 2010 Week 12 Hansard (Thursday, 28 October 2010) . . Page.. 5293 ..
MR SPEAKER: Ms Bresnan, a supplementary?
MS BRESNAN: Thank you, Mr Speaker. Minister, can you please advise whether patients are always treated in accordance with their advance care plan and, if not, why not?
MS GALLAGHER: It is certainly my understanding that that is the case when they come into hospital. I know this has been an issue that the Public Advocate and ACT Health and, indeed, the ACT Government Solicitor, have spent a fair bit of time working through. I think there have been individual cases where there have been some concerns around implementing advance care directives, whether they have come from family members or from clinical staff. But, to my knowledge, clinical staff are implementing advance care directives in accordance with patient wishes.
MS LE COUTEUR: A supplementary, Mr Speaker.
MR SPEAKER: Yes, Ms Le Couteur.
MS LE COUTEUR: Minister, can you advise what measures the government has taken to make patients and healthcare providers aware of the advance care program and have these measures been successful?
MS GALLAGHER: I will check whether ACT Health have done some specific staff information around this. At the time that it was being discussed with the Public Advocate I know the Public Advocate was certainly involved in the dissemination of information around this. But I will check whether Health have done any specific training.
I know that it is an issue that engages clinical staff very closely and I know, from all the discussions I have head with the health professionals involved in implementing advance care directives, they always try to abide by the wishes of patients. I am aware of some very complicated cases where there have been mixed views around individual patients but those have usually been worked through between the clinician and the families. But I will check.
MS HUNTER: A supplementary, Mr Speaker.
MR SPEAKER: Yes, Ms Hunter.
MS HUNTER: Minister, what are the current limitations of advance care plans in the ACT with regard to patients’ preference for how they wish to be treated when dying of a terminal illness?
MS GALLAGHER: I am sorry, just the end?
MS HUNTER: Of a terminal illness.
MS GALLAGHER: What are the limitations? There are some very complex issues here that do take up clinicians’ time and lawyers’ time. It really focuses on the issue


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Affin Investment Bank head of retail research Nazri Khan said the market was undergoing a temporary setback after the recent gains.
At 5pm, the underlying FTSE Bursa Malaysia (FBM KLCI) ended the day at 1,566.05, up 3.23 points, aided by bluechips which remained strong.
Nazri said the temporary easing would likely continue for one or two days as the market was in an overbought position.
“Bluechips remain strong and this clearly shows that fundamentals are intact.
“Most Asian indicies were down but on the local front, key indicies were steadier,” he said.
Nazri also said Moody’s downgrade of six countries in the euro zone and its warning to downgrade top-rated countries also affected investor sentiment globally.
The Finance Index earned 75.13 points to 13,902.7, the Industrial Index perked 5.63 points to 2,912.1 while the Plantation Index eased 43.69 points to 8,881.55.
The FBM Emas added 4.1 points to 10,882.63, the FBM Mid-70 gave up 51.62 points to 12,373.27 and the FBM Ace Index dwindled 41.87 points to 4,704.
Trading volume was lower at 2.546 billion shares, worth RM2.258 billion, compared with yesterday’s 2.661 billion shares worth RM2.119 billion.
Market breadth was bearish with 58l losers and 321 gainers, 288 unchanged, 290 untraded and 15 suspended.
Volume leaders, Hibiscus Petroleum perked 31 sen to RM1.82, British American Tobacco advanced 28 sen to RM51.78 and Fraser & Neave Holdings rose 24 sen to RM17.60.
Among heavyweights, Maybank added two sen to RM8.52, Sime Darby and Petronas Chemicals gained three sen each to RM9.64 and RM6.98, respectively, while CIMB rose 15 sen to RM7.31.
Volume on the main market fell to 1.753 billion shares, valued at RM2.138 billion, from 1.766 billion shares, worth RM1.959 billion, registered yesterday.
Turnover on the ACE Market slipped to 503.694 million units, worth RM71.210 million, from 568.432 million units, valued at RM105.312 million, recorded previously.
Warrants also eased to 284.233 million shares, valued at RM46.726 million, from 299.666 million shares, worth RM51.666 million, transacted yesterday.
Consumer products accounted for 128.153 million shares traded on the Main Market, industrial products 234.927 million, construction 64.464 million, trade and services 863.870 million, technology 76.592 million, infrastructure 28.576 million, finance 75.025 million, hotels 2.668 million, properties 167.687 million, plantations 24.872 million, mining 154,000, REITs 7.719 million and closed/fund 42,800.


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A novel mutation in early‐onset sarcoidosis/Blau syndrome: an association with Propionibacterium acnes
Pediatric Rheumatology volume 19, Article number: 18 (2021)
Early-onset sarcoidosis (EOS) and Blau syndrome (BS) are systemic inflammatory granulomatous diseases without visible pulmonary involvement, and are distinguishable from their sporadic and familial forms. The diseases are characterized by a triad of skin rashes, symmetrical polyarthritis, and recurrent uveitis. The most common morbidity is ocular involvement, which is usually refractory to conventional treatment. A gain-of-function mutation in the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) gene has been demonstrated in this disease; however, little is known about the relationship between the activation of NOD2 and the pathophysiology of EOS/BS. Here we describe EOS/BS with a novel mutation in the NOD2 gene, as well as detection of Propionibacterium acnes (P. acnes) in the granulomatous inflammation.
An 8-year-old Japanese girl presented with refractory bilateral granulomatous panuveitis. Although no joint involvement was evident, she exhibited skin lesions on her legs; a skin biopsy revealed granulomatous dermatitis, and P. acnes was detected within the sarcoid granulomas by immunohistochemistry with P. acnes-specific monoclonal (PAB) antibody. Genetic analyses revealed that the patient had a NOD2 heterozygous D512V mutation that was novel and not present in either of her parents. The mutant NOD2 showed a similar activation pattern to EOS/BS, thus confirming her diagnosis. After starting oral prednisolone treatment, she experienced an anterior vitreous opacity relapse despite gradual prednisolone tapering; oral methotrexate was subsequently administered, and the patient responded positively.
We presented a case of EOS/BS with a novel D512V mutation in the NOD2 gene. In refractory granulomatous panuveitis cases without any joint involvement, EOS/BS should be considered as a differential diagnosis; genetic analyses would lead to a definite diagnosis. Moreover, this is the first report of P. acnes demonstrated in granulomas of EOS/BS. Since intracellular P. acnes activates nuclear factor-kappa B in a NOD2-dependent manner, we hypothesized that the mechanism of granuloma formation in EOS/BS may be the result of NOD2 activity in the presence of the ligand muramyl dipeptide, which is a component of P. acnes. These results indicate that recognition of P. acnes through mutant NOD2 is the etiology in this patient with EOS/BS.
Sarcoidosis is a multiorgan inflammatory disease with unknown etiology, characterized by the histological features of noncaseating epithelioid cell granulomas . Two distinct types of sarcoidosis have been reported in children: classic sarcoidosis (CS) and early-onset sarcoidosis (EOS) [1, 2]. The former, clinically characterized by a triad of lung, lymph node, and eye involvement, similar to its manifestation in adults, presents in older children and is detectable via chest radiography. The latter is quite rare and found in younger children, presenting with a triad of skin, joint, and eye disorders with no apparent pulmonary involvement.
EOS and Blau syndrome (BS) are systemic inflammatory granulomatous diseases [1, 3]. The pathophysiology is the same for both diseases; however, differentiation between the sporadic and familial (autosomal dominant inheritance) forms is possible . Clinically, in both diseases, the cutaneous and articular symptoms primarily appear in children aged < 4 years [4,5,6], while ocular manifestations typically appear between the ages of 7 and 12 years . On the other hand, the most common morbidity associated with EOS/BS is ocular involvement that is usually refractory to conventional treatment, including continuous local and systemic glucocorticoids .
In 2001, NOD2 was identified on chromosome 16q12 as the gene responsible for EOS/BS [1, 3, 7, 9]. The NOD2 gene is intracellularly expressed in phagocytic cells and recognizes muramyl dipeptide (MDP), a component of the bacterial peptidoglycan, inducing an immune response through nuclear factor-kappa B (NF-κB) activation. NOD2 mutations in patients with EOS/BS enhance the self-oligomerization of NOD2, leading to augmented NOD2 activity even in the absence of the ligand MDP; further increases in activity by the addition of ligands represent gain-of-function mutations, consistent with the dominant mode of inheritance of the granulomatous disease [10, 11]. However, genetic screening of the NOD2 gene revealed no common mutations in Japanese and Caucasian CS patients [12, 13].
Despite a number of relevant studies, little is known about the relationship between the activation of NOD2 and the pathophysiology of EOS/BS . The etiologic aspect of CS as an allergic endogenous infection has recently been elucidated; CS is most likely the result of a complex interaction between infection, immunity, and allergic reaction. Sarcoid granulomas form in patients with a hypersensitive immune response to Propionibacterium acnes (P. acnes). They are formed primarily as a host defense mechanism against intracellular P. acnes activated at the sites of latent infection to prevent the spread of the infectious agent .
Conversely, no reports have described the association between EOS/BS and P. acnes. Contrary to the asymptomatic and sometimes naturally resolving form of the disease found in CS, EOS/BS is progressive and often leads to poor prognoses, such as blindness or joint destruction . Clarifying the pathogenesis of EOS/BS is essential for preventing a poor prognosis. Considering all these factors, we describe here a case of EOS/BS with a novel mutation in the NOD2 gene as well as the presence of P. acnes in the granulomatous inflammation of the biopsied skin tissue.
During early infancy, a Japanese girl developed papules on her legs and the dorsum of her hands. While the condition remained undiagnosed, the papules on her hand disappeared spontaneously at the age of 4 years. At age 5, she developed both conjunctival hyperemia and photophobia in her left eye; she was diagnosed with anterior uveitis, which was effectively treated using localized therapy. At age 7.5, she developed central scotoma and sudden visual loss (left > right) that was diagnosed as granulomatous panuveitis, which was effectively treated using local glucocorticoid therapy.
By age 8, the granulomatous panuveitis had flared up again; anterior chamber inflammation was seen in both eyes, and mydriasis had developed in the right eye due to posterior synechiae (Fig. 1a). The fundus was characterized by bilateral multifocal choroiditis presenting as creamy yellow lesions, and a scar was seen in the macular region of her left eye (Fig. 2). Systemic glucocorticoid therapy was therefore needed to preserve sight in the left eye. Laboratory tests showed hemoglobin level (11.9 g/dL), white blood cell count (6.22 × 109 /L), platelet count (292 × 109 /L), erythrocyte sedimentation rate (5 mm/h; reference range [RR], 5–15 mm/h), C-reactive protein level (0.01 mg/dL; RR, < 0.27 mg/dL), and matrix metalloproteinase-3 (16.4 ng/mL; RR, < 20.0 ng/mL); the tests for antinuclear antibodies and rheumatoid factor were negative. Her immunological tests were normal, and there were no episodes of recurrent or severe bacterial or fungal infection. Therefore, no additional tests, such as a flow cytometric dihydrorhodamine neutrophil respiratory burst assay, were performed to rule out chronic granulomatous disease. Magnetic resonance imaging of the extremities was carried out to evaluate the presence of arthritis; no abnormalities were detected.
A skin biopsy from papules on her leg indicated granulomatous dermatitis (Figs. 1b and c and 3). The biopsy samples were examined by immunohistochemistry (IHC) with a P. acnes-specific monoclonal antibody (PAB antibody, D371-3, MEDICAL & BIOLOGICAL LABORATORIES CO., LTD., Aichi, Japan) and a mycobacteria-specific monoclonal antibody (LAM antibody, D372-3, MEDICAL & BIOLOGICAL LABORATORIES CO., LTD.), according to the methods described in the original study . The PAB antibody detected several signals of round bodies within the sarcoid granulomas and in lesions infiltrated by inflammatory cells, while no positive signal was observed using the LAM antibody as control (Fig. 4). The sarcoid granulomas were comprised of CD4+ cells and CD68+ cells; CD8+ cells were rarely observed in the dermis and subcutaneous tissue (Fig. 5).
Genetic analyses were performed of both the patient’s and her parents’ NOD2 genes. Genomic DNA was extracted from the peripheral blood of the patient and her parents, and all 12 exons of the NOD2 gene, including exon-intron boundaries, were amplified by polymerase chain reaction and sequenced by Sanger method. Results revealed that the patient had a heterozygous c.1535A > T mutation on exon 4 in the nucleotide-binding domain of NOD2, while her parents did not. Analysis of the protein variant revealed that the mutation was D512V (p.Asp512Val) (Fig. 6). An NF-κB luciferase assay was performed. HEK293T cells (1 × 105) were cotransfected with 30 ng of the expression construct of the NOD2 variant together with an NF-κB reporter plasmid. NF-κB activity was measured after 12 h of incubation either with or without 5 µg/mL MDP. A mock vector and the wild-type NOD2 were used as controls ; R334W and H496L were used as positive controls . An in vitro assessment of the mutation indicated an increased basal NF-κB activity that increased further after MDP stimulation , demonstrating a strong association with EOS/BS.
Based on her clinical, histological, and genetic features, the patient was diagnosed with EOS/BS despite the absence of arthritis during the course of the disease. She was treated with oral prednisolone (PSL) (1.5 mg/kg/day). Six months after initiating treatment, she experienced a relapse of anterior vitreous opacity while on a 0.3 mg/kg/day dose of oral PSL, which was then gradually tapered. Oral methotrexate (10 mg/m2/week) was prescribed as an additional treatment, to which there was a positive response. She has remained in clinical remission for over three years on a 0.1 mg/kg/day dose of oral PSL with methotrexate.
This report describes a case of EOS/BS with a novel D512V mutation in the NOD2 gene and a lack of arthritis. P. acnes was also detected in the granulomatous inflammation, which leads to the elucidation of the etiology of EOS/BS.
Our patient did not show any symptoms of arthritis. However, the most common manifestation of EOS/BS is symmetric and usually painless polyarthritis . Only three mutations, E383K, R587C, and R334W, were identified previously in EOS/BS patients without arthritis [18, 20]. The R334W mutation in the NOD2 gene is one of the most frequently occurring mutations in patients with EOS/BS [18, 20]. The patient with R587C mutation was a familial case with an age of onset of 216 months, and demonstrated skin rash without arthritis and uveitis . Her daughter, who had the same mutation, was the proband of the disease and had rash, uveitis, and arthritis with an age of 21 months at onset . It may be difficult to identify phenotypic variations, such as the timing and site of onset and the clinical severity of EOS/BS, according to the NOD2 genotype. Nongenetic factors such as environmental conditions and/or infectious agents might be involved in phenotypic variation and clinical severity. Therefore, in individuals with NOD2 mutations, P. acnes might be the trigger for onset of the disease and may determine the onset site by causing intracellular proliferation from a latently infected state. In our patient, translocation of P. acnes after local proliferation at the early onset site of the skin may have caused latent infection only in the eye (but not in the joint), where later reactivation caused uveitis (but not arthritis).
Our patient had a novel D512V mutation of the NOD2 gene. Functional analysis showed elevated background activity and augmented activity after ligand stimulation, demonstrating a strong association with EOS/BS. A recent report elucidated the etiological aspect of CS as an allergic endogenous infection caused by P. acnes . Histological localization of P. acnes within sarcoid granulomas of the lymph nodes has been demonstrated by in situ hybridization  and IHC with PAB antibodies , suggesting that P. acnes is related to the cause of granuloma formation in CS. P. acnes has also been found in the cutaneous sarcoid granulomas of CS patients by IHC with PAB antibodies [22,23,24,25,26]. PAB antibody is a P. acnes-specific monoclonal antibody that reacts with lipoteichoic acids that are membrane-anchored molecules in the cell envelopes of gram-positive bacteria. In our case, using the same PAB antibody used in the previous studies, IHC detected several round bodies of P. acnes both within and around the sarcoid granulomas. The granulomas were comprised of CD4+ and CD68+ cells, indicating that they formed by the accumulation of CD4+ T-lymphocytes and macrophages. Therefore, the granulomas may have developed as a Th1 immune response to P. acnes.
P. acnes has also been demonstrated in ocular CS lesions. Nagata et al.  reported that P. acnes was present within granulomas in 10 (83 %) of 12 retinal biopsy samples from 9 (82 %) of 11 patients with ocular CS, whereas it was not detected in any (0 %) of the control group; the bacteria were identified as round bodies that reacted with PAB antibody. The retina is an aseptic environment and the presence of P. acnes within the retina is extremely unusual; therefore, detection of P. acnes within the retina was a critical observation, confirming the role of P. acnes as an etiological agent for CS. P. acnes is commensal on the skin, including sebaceous follicles, but usually absent in the dermis; therefore, we considered that detection of P. acnes within the sarcoid granulomas in the dermis strongly suggested P. acnes as an etiological agent for EOS/BS.
Tanabe et al.  found that both NOD1 and NOD2 proteins recognized intracellular P. acnes. Furthermore, systematic searches for NOD1 gene polymorphisms in Japanese CS patients identified an increased frequency of G796A. Functional analysis revealed that NOD1 G796A was associated with a lower expression at the protein level, leading to reduced NF-κB activation in response to intracellular P. acnes. These results indicated that impaired recognition of intracellular P. acnes through NOD1 variants might cause susceptibility to CS within the Japanese population. We, therefore, hypothesized that the mechanism of granuloma formation in EOS/BS may be the result of NOD2 hyperactivity in the presence of the ligand MDP, a component of P. acnes.
We found that EOS/BS and CS share a common feature of P. acnes in granulomatous pathology; however, the reason for the differing clinical features (especially the different triad of symptoms) between EOS/BS and CS remains unknown. It may be related to the presence or absence of NOD2 mutations, or different sites of preceding latent infection of P. acnes in EOS/BS and CS. The lack of arthritis in our patient may indicate the lack of latent infection. Additionally, it remains unknown how the hyperactivity of NF-κB without MDP stimulation is involved in the pathophysiology of EOS/BS. The gain-of-function NOD2 mutations found in EOS/BS patients may cause an excessive immune response to P. acnes, with increased NOD2 activity in the presence of MDP; this excessive immune response to P. acnes would lead to poor prognosis.
Nagakura et al.  reported that tumor necrosis factor inhibitors provide long-term clinical benefits in EOS/BS. Thus, it would be one of the candidate treatments in the case of a later relapse. Furthermore, according to the identification of P. acnes in our patient, a combination of antibiotic and symptomatic therapy might be considered as a novel treatment for EOS patients. Antibiotics against P. acnes may be effective for patients with progressive CS by preventing relapses of inflammation caused by repeated reactivation of the latent bacteria . The result of a nationwide questionnaire survey, performed by a Japanese research group in 2005, indicated that antibiotic therapy was effective in 43 % of patients with CS treated with several kinds of antibiotics, including minocycline, doxycycline, and clarithromycin . This study therefore provides scope for future research.
In summary, we presented a case of EOS/BS with a novel D512V mutation in the NOD2 gene. In refractory granulomatous panuveitis cases without joint involvement, EOS/BS should be considered as a differential diagnosis; genetic analyses would lead to a definite diagnosis. Moreover, this is the first report of P. acnes demonstrated in granulomas of EOS/BS. Since intracellular P. acnes activates NF-κB in a NOD2-dependent manner, we hypothesized that the mechanism of granuloma formation in EOS/BS may be the result of NOD2 activity in the presence of the ligand MDP, which is a component of P. acnes. These results indicate that recognition of P. acnes through mutant NOD2 is the etiology in this patient with EOS/BS.
This patient is the same as the D512V case reported in reference number 18. There was no polyarthritis or renal calcification in this patient. In fact, the statement that polyarthritis and renal calcification were present is an error made by the authors of reference number 18, and is currently being corrected by them for submission of an erratum.
Availability of data and material
Nuclear factor-kappa B
- NOD2 :
Nucleotide-binding oligomerization domain-containing protein 2
Propionibacterium acnes-specific monoclonal
- P. acnes :
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We thank the patient, her family, and their friends for their cooperation.We would like to thank Editage (www.editage.com) for English language editing.
This work was supported in part by JSPS KAKENHI Grant Number JP19K17908.
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Informed consent was obtained from the patient’s guardian for publication of this case report.
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Okazaki, F., Wakiguchi, H., Korenaga, Y. et al. A novel mutation in early‐onset sarcoidosis/Blau syndrome: an association with Propionibacterium acnes. Pediatr Rheumatol 19, 18 (2021). https://doi.org/10.1186/s12969-021-00505-5

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text:
Hold onto your hats, cat-loving sleuths! We’re delving deep into the enigmatic world of “Cat in the Chrysalis,” a story brimming with telepathic felines, star-crossed romance, and mysteries lurking in the shadows. But for those hungry for a peek behind the curtain, prepare to have your curiosity piqued – this post serves as your ultimate guide to “Cat in the Chrysalis” spoilers, theories, and more!
A Whiskered World: Navigating the Landscape of Spoilers
Before we unleash the spoilers like mischievous kittens, let’s set the stage. “Cat in the Chrysalis” follows the intriguing journey of Kit, a woman with an extraordinary connection to her feline companion, Chrysalis. Whispers of hidden agendas, forbidden love, and secrets intertwined with the fate of a celestial empire keep readers on the edge of their seats. But beware, venturing into spoiler territory comes with consequences! So, if you haven’t yet embarked on this captivating story, consider this your fair warning (and perhaps a gentle nudge to dive in!).
The Hidden: Major Plot Twists and Shocking Revelations
Now, for the thrill-seekers, we’re cracking open the spoiler vault! Brace yourselves for some jaw-dropping moments:
The True Nature of Chrysalis: The cat we adore hides a profound secret. Chrysalis is not just a feline with telepathic abilities, but a descendant of an ancient race connected to the celestial realm. Their bond with Kit forms a crucial bridge between worlds, setting the stage for epic conflicts and thrilling discoveries.
Love Blossoms and Withers: The love triangle in “Cat in the Chrysalis” is anything but predictable. While Kit’s heart initially leans towards the dashing Edwin, unexpected turns reveal hidden affections and forbidden desires. Prepare for tears and triumphs as Kit navigates the treacherous waters of love and loyalty.
Betrayal Runs Deep: Not everyone is who they seem, and trust becomes a precious commodity. Shocking betrayals from seemingly close allies rock Kit’s world, forcing her to question everything she knows. Be prepared for alliances to shift and loyalties to crumble as the story unfolds.
The Prophecy Unfurled: Whispers of a hidden prophecy echo throughout the narrative, hinting at Kit’s pivotal role in shaping the fate of both worlds. As the mysteries unfurl, the stakes rise, culminating in a nail-biting climax that will leave you breathless.
Beyond the Ending: While the conclusion of “Cat in the Chrysalis” offers a satisfying resolution, it also leaves space for further exploration. Teasers of unresolved conflicts and lingering questions hint at potential continuations or spin-offs.
Beyond the Spoilers: Theories and Speculations Abound
Now that we’ve indulged in some juicy spoilers, let’s engage in the delightful dance of speculation!
The Whispering Forest: The enigmatic presence of the Whispering Forest throughout the story begs the question – will it play a more significant role in future installments? Could it hold the key to unlocking ancient secrets or harboring unforeseen dangers?
Chrysalis’ True Potential: We’ve glimpsed flashes of Chrysalis’ immense power, but is that all they’re capable of? Their untapped potential fuels theories about their future role and whether they may hold the key to saving both worlds.
Hidden Agendas: Betrayal lurks in the shadows, but who else harbors hidden motives? Could seemingly innocuous characters be pulling the strings from behind the scenes? Examining side characters through a suspicious lens adds a whole new layer of intrigue to the story.
The Threads: Exploring Symbolism and Deeper Meanings
“Cat in the Chrysalis” weaves a tapestry rich with symbolism and deeper meanings. Let’s untangle some of the threads:
The Transformation of the Chrysalis: The chrysalis is not just a physical structure but a metaphor for Kit’s own journey of transformation. As she navigates challenges and discovers her true power, she sheds her past limitations and emerges stronger and more confident.
The Power of Connection: The bond between Kit and Chrysalis underscores the importance of connection and mutual understanding. It transcends species and language, demonstrating the profound impact of empathy and shared experiences.
Light and Shadow: The recurring themes of light and shadow represent the constant struggle between good and evil, hope and despair. This ongoing battle becomes the driving force behind the plot, leaving readers to ponder the choices they themselves make in the face of adversity.
“Cat in the Chrysalis” is not just a captivating read; it’s an invitation to delve deeper into a world brimming with hidden potential. The journey with Kit and Chrysalis leaves us pondering our own inner strength, the power of connection, and the choices we make in the face of darkness. While the narrative’s threads have been expertly woven together, the ending leaves space for continued exploration, leaving readers yearning for more adventures in this enigmatic world. So, whether you’re a die-hard spoiler hunter or a theory-crafting mastermind, “Cat in the Chrysalis” offers a purrfectly enticing invitation to lose yourself in its mysteries and wonder what lies beyond the final page.
1. Will there be a sequel to “Cat in the Chrysalis”?
The author has not yet confirmed a sequel, but the open-ended conclusion and lingering questions certainly leave room for further adventures. Stay tuned for future announcements!
2. Where can I find fan theories and discussions about the book?
Several online communities and forums gather devoted fans eager to dissect the story, share theories, and speculate about the future. Join the conversation and add your own interpretations to the mix!
3. Does the book contain adult content or violence?
While “Cat in the Chrysalis” primarily targets young adults, it contains some mild violence and romantic elements. Consider this when selecting the book for readers of varying sensitivities.
4. Who are some of the key characters in the book?
Besides Kit and Chrysalis, readers will encounter a rich cast of characters, including Edwin (Kit’s love interest), Luna (a mysterious celestial being), and the enigmatic Council members who hold the fate of the worlds in their hands.
5. What themes are explored in the book?
“Cat in the Chrysalis” delves into themes of self-discovery, loyalty, the power of love, and the fight between good and evil. It also explores the unique connection between humans and animals, adding a heartwarming layer to the story.

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The Government should focus on investing in cities outside of London rather than spreading investment too thinly across small towns, a think tank has recommended.
In a new report launched today, the CAGE Research Centre found that cities are the most popular places to live in the UK despite a small boom in the purchase of rural properties in August 2020.
Based in the Department of Economics at the University of Warwick, the research centre also found that London remains the most popular area to live and work. This is despite high house prices in the capital and the stagnation of London wages.
CAGE argues that the desire for urban living revealed in the data, and the increasing squeeze on Londoners’ disposable incomes, reveals an opportunity to tackle regional inequality. In order to do so, the researchers recommend the Government invest in cities outside of the capital.
Director of CAGE and co-author of the research, Professor Mirko Draca, explained: ‘Though London remains the main attraction, our data shows that across the UK, people like living in cities. If the Government is serious about challenging the economic power of London and boosting the regions, it needs to put cities at the centre of its agenda.’
‘There’s a real danger that the Government is spreading its bets too thinly,’ Professor Draca continued.
‘Its current plans to invest in many different towns to break the economic dominance of London is like setting up acoustic tents to draw crowds away from the main stage at Glastonbury. The Government needs to place bigger bets on fewer places. Investing in cities that can rival London is the best way to tackle regional inequality for the long-term.’

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text:
Aggravated assault in Poplarville, bond set for Ladner
Published 7:15 pm Thursday, May 1, 2008
Poplarville Police officers responded to a call and made an arrest in an aggravated assault case Sunday evening, and bond has been set for a Poplarville man charged with manslaughter.
Poplarville Police Chief Charles Fazende said Patrick Johns, 17, of Poplarville, was charged with aggravated assault after he allegedly attacked an individual at the victim’s home.
The victim answered a knock at the door and was attacked by Johns, who beat the victim up with brass knuckles and threatened the victim with a handgun, Fazende said. The police chief said the victim did not know any motive for the beating.
The victim was treated at the scene for cuts to the face and mouth.
Johns is being held without bond at the Pearl River County Jail.
In other police news, a bond hearing was held Wednesday for Jeremy Russell Ladner, who was arrested for the Sunday shooting death of 16 year old Shaun Phillip Allen.
Ladner, 20, turned himself in to investigators after originally fleeing the scene of the crime.
Bond for Ladner has been set at $60,000.
He is being held at the Pearl River County Jail at Millard.

domain: sociology


text:
Kill the Villainess
Genre: Comedy, Drama, Fantasy, Historical, Manhwa, Romance, Shoujo
I reincarnated in a novel inside the body of a villainess named Elise who poisoned herself when her fiancé, the prince, married her childhood friend, the maid Helena. From the moment I realized this, I had only one goal. Escape from the world in this novel. Even after death, I tried to get out of this world but the ‘world’ did not allow it. However, after rejecting the path of “Elise” in the original novel, the men who had persecuted and ignored Eris began to beg for her interest and affection. “Who are you?” the priest who revived Helena asked. “You… are you really Elise?” even the warrior who pledged eternal loyalty to Helena asked. “You have changed,” said the prince who rejected Elise in order to marry Helena. It was strange. No one was interested in Elise before. “I don’t want to get affectionate even as time passes.” She has no confidence in loving this world.
*MIGHT CONTAIN SPOILERS! READ IT AT YOUR OWN RISK! IF NOT, READ THE REVIEW ON MY IG PAGE.*
I LOVE IT I LOVE IT I LOVEEEEEEE IT!!! At first I really disliked the FL because of how she doesn’t want to just make the best use of her life and rather return to her old life. But once I learned and understood more about her circumstances, I actually found this very unique and enjoyable. This reminds me of “It Looks like I have Fallen into a Reverse Harem Game” except this aint a reverse harem. I really love the knight who is protecting her and am so glad that there IS an ML here because I thought she will be helpless in that fictional world. I love the couple a lot and I am so excited to know how this story will turn out. Highly recommended!!!
For those who want spoilers: It is really not much so though the link is below, will not really recommend reading but if you want to know the ending then go ahead.
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~ THANK YOU ~
Follow @watashiwakurousagi for more!


text:
Click on a thumbnail to go to Google Books.
All flags flying : American patriotic quilts as expressions of liberty (edition 1986)
All Flags Flying: American Patriotic Quilts as Expressions of Liberty by Robert Bishop
No current Talk conversations about this book.
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domain: library


text:
This New Home Decor Collaboration Is So Sunny and High-End
It's always this time of year that we start craving a departure from the dark tones and temps of winter.
Here to provide the (visual) antidote? This whimsical new home decor collection—a joint effort between Bri Emery of Designlovefest and custom furniture house Cloth & Company, sold exclusively at Target.
The collab draws its inspiration from Emery's recent travels to Mexico, and from the soft, sherbety palette (a nod to desert sunsets) to the minimalist block prints (an homage to native textiles), it truly has us plotting a holiday. Not to mention, well...a decor update.
Take a peek at our favorite pieces below.
Blackout curtain in Yuma light pink; ($180)


text:
JOIN THE YMCA. WHERE FAMILIES THRIVE.
Belong to something greater and pay no join fee!
The Southwest YMCA is a community gathering place for healthy living, youth development, and social responsibility. A YMCA membership will help you kick start your fitness plan in a friendly, welcoming environment through free personalized fitness coaching, a wide variety of group exercise classes, convenient access to 5 Metro Denver locations, state-of-the art fitness equipment, top quality childcare while you workout, and fun activies for the whole family.
YMCA Membership includes:
YMCA members are part of a community of people who want to make a difference for our children, seniors, families, and future. The Y is 100% focused on youth development, healthy living, and social responsibility.
Financial assistance is offered to individuals and families, click here for more information.


text:
Two operators -- Indosat and Hutchison 3 Indonesia -- were awarded the 2.1 GHz radio frequency for mobile cellular network operations that is worth Rp 423.08 billion (US$31.17 million).
The Communication and Information Ministry announced the result in a press statement.
Hutchison 3 Indonesia (Tri) vice president director Danny Buldansyah welcomed the decision, adding that with it, his company would be able to optimize Tri’s mobile broadband service.
“With the additional spectrum, we will optimize our existing BTS. In certain areas, we can directly serve our customers with 4G, while in other areas, we can serve our customers with 3G,” said Danny as reported by kontan on Monday.
The ministry said the 2.1 GHz frequency auction was attended by three participants -- Indosat, Hutchison 3 Indonesia and XL Axiata.
Danny expressed the hope that the government would open another tender to support efficiency in the telecommunication industry because of the increasing demand.
After winning the auction, Tri currently has a total capacity of 25 MHz -- 10 MHz in 1,800 MHz frequency and 15 MHz in 2.1 GHz frequency. (bbn)


text:
Free Slots and Their Basics
Free slots refer to internet slot machines, which you are able to play and enjoy completely free without actually wagering any actual cash on them. The free slots which provide this kind of functionality are the same as those you will discover in online casinos however will most likely be operated via a “practice” or “free mode” rather than via the actual internet. Generally speaking you will not be able to change the starting denomination with one of these types of free slots. The best you can do is to adjust the starting jackpot and the reels which come on for a spin in order to make your bet. In most cases these free slots will only have one denomination, that is the maximum it is possible to get on any single spin. As you will recall, in online casinos you will discover a maximum of two jackpots that will rotate around by the end of every game.
Another difference between online slots which provide free slots and those which involve real money may be the chance of getting the results you are looking for. Once you place a bet with an online casino, you have the opportunity to pick your outcome in several ways. For example you might decide to receive a minimum amount of chips for your bets, you may opt to double your initial bet or simply even receive a percentage of your initial bet back. With free slots the only outcome that is possible may be the one which is printed on the device.
One of many differences between free slots and the ones which involve real cash is that the latter usually offer no bonuses or promotional codes. Therefore, when playing 엠 카지노 slots with free spins you will not be able to profit any bonuses or share points. However there are a few online casinos which offer free slots which supply the player the opportunity to profit points, bonus codes etc. These types of clots can often be found alongside real money slots.
Occasionally you do not actually have to play free slots but rather can use a particular code to access a certain jackpot slot. This is referred to as the instant play slots. A few of these instant play slots work similarly to mini slot games where a certain number of coins are essential by all players to be able to “win” the overall game. Once enough coins are accumulated, the ball player will become the winner of the game. As with real money games the winner usually gets a prize and this is generally a jackpot worth a great deal of money.
Free slot games also differ for the reason that many of them offer cumulative jackpots that increase with every game played. The best free slots include slots offering cumulative jackpots of over a million dollars. They are the highest forms of free slots available and they are the ones that attract the most players. Players can get very large prizes from these kinds of slots. Among the best strategies to employ when using these cumulative jackpots is to play so long as possible in order to maximize your odds of winning the jackpot prize.
In addition to the actual free slots there are also progressive jackpots and bonus rounds. With progressive jackpots you can earn more credits after you hit certain targets on the reel or card spins. These credits may then be used towards earning a lot more money! Bonus rounds on the other hand are a series of small promotions that you get in the middle of a casino game, the winners of which get a jackpot prize.
Jackpots and bonus rounds are what make online slot games so popular. A lot of people desire to win these jackpots also to take advantage of the additional prizes they offer. As such, they play just to win and they end up losing a lot of cash as a result. This is why it’s important that players study slot strategy so they do not lose money through incorrect strategy.
Some of the strategies that are associated with free slot games could be difficult for a beginner to comprehend. For this reason, it is best that beginners practice with fake money before playing for real cash. You should never spend real cash without ensuring that you’re acquainted with the payout rates, jackpot amounts, and the codes for the bonuses you’re receiving. Once you feel confident enough to play for real money, you can continue playing with virtual money to gain more experience.

domain: entertainment


text:
Soul Survivor explores the depths of human emotions, both real and imagined. That any of us reach adulthood in one piece, emotionally or physically is a miracle of no small proportion. That any of us reach adulthood to contribute back to society and become highly respected in the community is truly a gift of time and place.
Soul Survivor is a true story of fortitude, an iron will and looking to the future in the hope that tomorrow will be better than today. Soul Survivor is nothing less than a story of triumph. “Little Mary” spent her childhood living, playing, and working in a funeral home. Her mother “Big Mary” was co-owner of a well known and respected mortuary in the African-American community in Los Angeles, CA. Little Mary’s story tells what really happens behind the embalming room doors- the light and dark side of life. Soul Survivor is both humorous and mischievous, and talks of sex, murder, voodoo, phony preachers and deviate gravediggers.
Famous entertainers that passed through Little Mary’s life include Redd Foxx, Lou Rawls, Sam Cooke, Billy Preston and Johnnie Cochran.
Little Mary was born in Shreveport, LA and reared in Los Angeles, CA. Often disparagingly referred to as “high-yellow.” During the racial tensions of the ‘50s and ‘60s Little Mary found her hue to be a major issue but not her only problem. Mary’s mother caused her to endure life threatening situations due to her drinking and wild ways. Little Mary’s childhood experiences, the mental and physical abuse faced each day, led her to believe that her only true friends were the dead people in the funeral home. Indeed, Little Mary received a BS degree (Be Smart) at an early age. It was the only way she knew to survive.
Little Mary’s story is an unlikely but revealing peek into the unexpected and in the end, truly a story of a Soul Survivor.
From the author of Soul Survivor comes a riveting work of fiction that’s based on an actual event. Author Mary Ross Smith invites readers to get to know the characters in the story for they may actually be individuals seen and met in some of the communities. SOS is not a cry for help, but rather a warning, a warning for all to open their eyes and really see the people they encounter everyday.
SOS introduces readers to an intriguing ensemble of characters that portray real people, immoral lifestyles, and seemingly fine individuals. This compelling story takes them to some incidents that would let them realize and experience the consequences of their actions. In a story that unveils a life of deception and betrayal, change and conversion, and more, readers will meet Eva, Rev. Andrews, Mr. Charles, Pearl, Sergeant Houston, Fred, Flo, and others whose lives are entwined because of the circumstances and community they are in.
Reverend Andrews has his immoral ways; despite his being a Pastor, he gives little thought to the negative effect his lifestyle has on his followers. Mr. Charles, the embalmer of a well-known mortuary, finds that someone is coming into the embalming room after hours, and seeks help from Sergeant Houston. Eva, owner of the mortuary and wife of Reverend Andrews, has her own deep dark secrets that threaten the life she has deftly created. Together with the other characters, they will witness a Pandora’s Box of lies, sex, greed, and deceit open before their very eyes.
SOS is an intricately woven story that may present a common issue, but one that’s not readily spoken about.
"I have just finished you book and the only thing I can say is 'WOW'! You are a wonderful person and to see what you have done is truly a gift. I'm so proud of you for writing this book and sharing it with all of us."
"Thank you so much for allowing me to read your story! Sometimes I felt like I was watching a train wreck and couldn't turn away. You were and are so strong!"
"I am in awe of you-
I am more convinced than ever that your story should be a movie so everyone who sees it can be inspired by your courage"
You were truly a brave "Lil Mary" who proved one can survive and become successful living in a dysfunctional home, dealing with prejudice, abuse and poverty. You have written your story to show the importance of perseverance, resiliency and what 'be smart' can do for all who have been faced with adversity and have overcome! I highly recommend your book to those who support and counsel others in overcoming the past and those who have had similar life experiences and can benefit from your story."
"Truly a 'tour de force,' riveting, compelling, honest - an emotional roller coaster through the experiential and psychological trials and tribulations of someone who courageously broke the cycle of rejection, verbal abuse, violence, and depression. You are a role model for many who need to hear your story, Little Mary. Indeed, the Almighty has a plan for you; you hung in there, and you awoke to a brighter tomorrow. Bravo!"
"I wanted to tell you that I just finished reading your book....WOW! It held my interest from cover to cover. What an amazing story."
An interesting story with a solid message. This story is an inspiring one with possibilities.
"'Soul Survivor' is a great book! It's really good and gripping."
"I finished your book last week WOW! You have quite a story! I found that I couldn't put the book down! I especially loved your last chapter where you pull it all together. Amazing! You are a great writer too!"
"I LOVED your book! I cried, I laughed and I rejoiced in your triumphs. PS Oprah needs to read this"
"Terrific! Oh Mary, you were great! Your talk was interesting. You speak from the heart and you are genuine. You touch the heart of the audience. May God bless you and use you to further His name."
The author does a good job of keeping your attention to the end. It is a page turner with many unexpected turns. A good read!
"What's done in the dark WILL come to light!!!
I read Soul Survivor and was truly captivated by the way the book so graphically told her story. I then picked up SOS and was surprised at the fact that I couldn't put it down. The face that every chapter lifted another level of intrigues kept me pulled into wanting to know the rest of the story...If you're looking for a real page turner that will keep you on the edge of your seat and your blood pulsating this is a great book..."
"I thought the first book of Soul Survivor couldn't be topped, but this book was so well written. I highly recommend this book, and I can guarantee you will find it very hard to put down. It's captivating from the beginning to the end."
"SOS is a wonderful book about the dangers of people with a combinatino of great charisma and no conscience. The suspense built around the question of when and how the guilty will be brought to justice is incredible. And the eventual result is anything but what you expect. An awesome follow-up to 'Soul Survivor'; 'SOS' fills in many of the questions left open in the first book. I highly recommend it to one and all."
"The is book is different from Soul Survivor. But you recognize the great writing by the author. This one was hard to read but I couldn't put it down. I can't wait for the next book from Mary Ross Smith or maybe even a movie about SOS. I think it would be award winning! I highly recommending this book."
"I was riveted to this story, felt I was right there with all the characters...I could FEEL everything....WOW...I loved the first book, Soul Survivor.......Mary you did it again...!!! Looking forward to your next one..."
"SOS is a story that hooks you from the first page to the last...She encourages the readers to look beyond what one thinks they see to what is really happening. You begin to question what does go on in some funeral homes and with some preachers...
Don't miss her first book, Soul Survivor, a very personal story, that captures many of the author's early life experiences."


text:
The Payments Suite for global business
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Fully remote, high speed on-boarding for 100+ jurisdictions. Open your global bank account and enjoy easy access to crypto, fiat and fair FX.

domain: economics


text:
Oil on canvas
21 1/2 x 18 1/4 inches (54.6 cm x 46.4 cm)
Framed: 28 1/2 x 25 inches (72.4 x 63.5 cm)
Signed with monogram: GdE
Sotheby’s London, 1993
Private Collection, USA
This painting is sold with a certificate of authenticity from Jean Dominique Jacquemond.
Born in Melun in 1870, Georges D’Espagnat’s family moved to Paris when he was a young man. He was largely self-taught as an artist, eschewing the traditional art schools and rejecting the strict formalities of the Paris academies, and instead studying the works of the great masters found at the Louvre. He became involved with prominent Impressionist painters of the time and began his public career at the Salon des Refusées in 1891, and later exhibited at the Salon of the Société Nationale and the Salon des Independents, both venues known for their openness to modern trends.
In 1895, D’Espagnat had his first solo exhibition at the Le Barc de Boutteville Gallery in Paris. In 1903 D’Espagnat, along with the architect Frantz Jourdain and critic Ivanhoe Rambosson, founded the Salon d’Automne with the purpose of creating an alternative exhibition venue for young artists and for retrospectives of the modern artists who had been rejected at the end of the earlier century. In 1907 his work was included in the Marcel Bernheim Gallery Group Exhibition with Bonnard, Cezanne, Matisse, Pissarro, Rouault, Seurat, and Toulouse-Lautrec. He was elected vice president of the Salon d’Automne in Paris in 1935, D’Espagnat was an active member at the Salon while teaching at the Ecole des Beaux-Arts until the 1940s. His work is in the collection of numerous museums and public collections such as the Metropolitan Museum of Art in New York, Musée du Theatre National de l’Opera in Paris, the Musée d’Orsay in Paris, the Museum of Fine Arts, in Boston, the National Museum of Western Art in Tokyo, Thyssen-Bornemisza Museum in Madrid.
Our painting juxtaposes rich, soaked color with a masterful understanding of composition and draftsmanship. Vivid reds and cool blues frame the backdrop of a still life table arrangement. Covered by a yellow cloth, the table is set with a domestic grouping that includes a vase of red and white flowers, a plate of decadent fruit, and a lidded blue and white sugar jar. This arresting work shows the influences of D’Espagnat’s contemporaries Bonnard, Cezanne, and Matisse.


Creating a Podcast
RSS - RSS stands for Real Simple Syndication and can be likened to a news feed. This software lets you subscribe to podcasts whether they originate from Villanova or from some other Internet location. You can subscribe to podcasts dealing with a wide range of topics and many of the leading news services offer podcasts too.
As with any other form of media or medium. If you are going to quote from a book, use lyrics from a song, or a song clip as part of your Podcast, you need to be sure that proper credit is given and that there is no violation of use.


text:
Polly-O Impastata 160 oz Bag
EXCELLENT SOURCE OF CALCIUM
Impastata Ricotta Cheese Polly-O Impastata Ricotta Cheese is made with premium quality natural ingredients using the classic Italian technique. Creamy and delicious, this ricotta cheese will add a little taste of Italy to every bite. Creamy Indulgence Transform your everyday meals into an indulgent experience with Polly-O Ricotta Cheese. Add it to pastries, pasta, casseroles and more for that mouth-watering creamy taste the whole family will love.

domain: food


text:
Lennon Eyeing Club Site / Son of late Beatle likes Maiden Lane
Published 4:00 am, Saturday, January 27, 1996
Julian Lennon is negotiating to open his planned restaurant, dance club and lounge, "The Revolution," in an empty three-story building on Maiden Lane between Grant and Stockton.
Lennon, 32, rock singer and son of the late Beatle, has been in town this week working on the club and paying his restaurant tabs with a "Revolution" credit card. He will be back next week for further negotiations, said his business partner, Todd Meagher, 34, of San Francisco.
"This is the ultimate space, frontage on both Geary and Maiden Lane," says Meagher. "With Maiden Lane we can bring tables out for the lunch crowd, and on Geary we can have a major entrance and a retail boutique."
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Meagher expects to close the deal within weeks and have the club open by November, a year after Lennon announced his intention to open a worldwide chain of clubs with the San Francisco spot as flagship.
The entertainment facility will be 20,000 square feet, with the dance club on the basement level, a restaurant at street level, and a jazz and rhythm and blues lounge upstairs on the mezzanine level.
"The key is to kill the proverbial San Francisco question, 'Where do we go after dinner?' " says Meagher. "We're trying to create an atmosphere where you can have an excellent meal and stay there and enjoy yourself. It's a one- stop place. You don't have to go out and worry about parking."
The "Revolution" theme is in reference to the healers of humanity, not the Beatles song, Meagher says. Heroes of change, locally and internationally, will be honored in a gallery of photography, artwork, paintings and sculpture.
Proceeds from sales will benefit the artist's preferred charities and the local arts community.


text: On March 20, 2017, participating Dairy Queens donated a free vanilla ice cream cone to anyone that came in to partake. The idea is that while there, people might drop in some change for Children's Miracle Network Hospitals around the country. Last year, stores raised more than $200,000 nationwide, and over the past 32 years, Dairy Queen has raised more than $120 million for the cause. Gonzales Primary Academy joined in by picking up an ice cream or two! Thank you, Dairy Queen, for all you do to support children in need!


text:
Are you a farmer dreading having to do the BAS? Are you trying to do everything yourself? Do you have a million other jobs to do?
I CAN HELP.
With 20 years of agricultural experience I know the industry like the back of my hand.
You didn’t become a farmer because you’re passionate about lodging your BAS, paying bills and paperwork, right? Why use your expertise and valuable time shuffling bits of paper?
I know there are a million jobs you could be doing:
Sowing, Hay cutting, Repairing machinery, Trading stock, Feeding stock, Lamb and calf marking, Drenching, Fixing fences, Controlling weeds, Making silage, Attending a field day, Controlling foxes, Shearing, Cleaning troughs, Harvesting, Paying bills.
And that is only half of it.
— Nelson Mandela

domain: agronomy


Intelligent Clearance Sonar
Toyota's current ICS function detects obstacles and helps prevent or mitigate collisions caused by rapid acceleration after pedal misapplication. The new ICS includes more sensors and can detect objects further away, contributing to an increase in scanning depth and breadth. In addition, the control logic has been improved to help prevent or mitigate collisions with adjacent vehicles or obstacles even when pedal misapplication is not the cause, such as during low-speed driving in parking lots or when pulling out of parking spaces.
Toyota's Intelligent Parking Assist system now uses ICS to help prevent or mitigate collisions through automated braking. In addition, a new multi-point turn support function automatically controls steering2 in tight parking spaces requiring repeated back and forth movements. Another partially-automated2 function assists departure from parallel parking spaces with little room in front of and behind the vehicle.


text:
One of our favorite day trips from Bath during our November Mozartfest tour is delightful little Wells, “England’s smallest city”.
Wells is named from three wells dedicated to St. Andrew the Apostle, one in the market place and two within the grounds of the Bishop’s Palace and cathedral.
Although the population recorded in the 2011 census was only 10,536, Wells has had city status since medieval times, because of the presence of Wells Cathedral, hence its label of England’s smallest city.
We always plan our visit for a Sunday, in order to enjoy the afternoon Evensong at 3:00.
The Crown, right in the market square beside the cathedral, is just the place for a traditional Sunday Roast. William Penn stayed in Wells shortly before leaving for America in 1682, spending a night at this very inn. He was briefly arrested for addressing a large crowd in the market place, but released on the intervention of the Bishop of Bath and Wells – I hope he got to appreciate a Sunday Roast before he left! We certainly enjoyed ours – Yorkshire Pudding and all. Walking through the vaulted passageway into the Cathedral Close, we pass the moat, swans peacefully paddling in the calm water, then enter the awesome Cathedral.
On this Sunday, rather than the usual boys choir, sweet young voices of girls sing the psalms and hymns as we sit with them in the beautifully carved choir, intricate tapestries and needlework adorning the seats.
Built in Early English Gothic style between the 11 and 1400s, the Cathedral is filled with awe-inspiring craftsmanship, such as the massive and unique scissor arches stabilizing the center after an earthquake left it weakened. Although this video is too dark – by the time Evensong is over at 4 the short winter day is dimming – I think you’ll enjoy the organ resounding in this splendid space.
The Chapter House, up a well-worn stairway, is another don’t-miss part of this ancient beauty. Built in 1306, this meeting place for church affairs would have been an inspiring place to conduct business, with its delicate tracery and vaults rippling across the ceiling, supported by a central pillar that’s been likened to a giant palm tree, spreading its foliage above.
Like many of the places we visit on this Bath Mozartfest Tour, Wells transports us back hundreds of years with its ancient beauty and the peaceful generation-spanning quiet of Evensong.
The best way to describe us (Kirk and Anne Woodyard) is that we’re interested in the stories that make the places we visit come alive. We’ve visited Europe more times than we can count, learned some entertaining stories there, and met some warm and helpful people who also enjoy the wonders of music and life in Europe. We look forward to sharing these stories and friends and experiences with our Music and Markets guests. Between our music-related travels, we split our time between our homes near Washington DC and the south of France.
While both of us have experience in organizing travel and music groups Kirk’s background is in project management and competitive writing, and Anne is an accomplished pianist with over thirty years of teaching experience, and a travel and food writer specializing in France and Italy.

domain: travel


text:
The Great Candy Bar Debate: Snickers vs. Kit Kat vs. Twix vs. Milky Way vs. Reese’s vs. Mars vs. Hershey’s vs. Nestle Crunch vs. Almond Joy vs. Butterfinger.
Best Candy Bar for Chocolate Lovers
For all the chocoholics out there, this list item explores the best candy bar options to satisfy that craving for rich, creamy, and smooth chocolate. From the classic Snickers to the indulgent Milky Way, the contenders in this category all have one thing in common – they deliver an exceptional chocolate experience.


Through continuous innovation, we have formed an advanced technology system in the development of 15 Inch X 15 Inch Elastic Cargo Net, Bungee Cord Spool, Galvanized Steel Hook Bungee Cord. Our corporate culture is mainly composed of the fine traditions of 'hard work' and 'precision and rigor', which are important connotations and a magic weapon to inspire us to overcome difficulties and continue to advance. 'Reputation To start with, Buyers Foremost. In recent years, our company has developed rapidly and the scale of operation is expanding day by day. Our company's team members are young and full of vitality, they think of customers in their hearts and look at problems from the perspective of customers.
Rubber reusable twist tie -size: 12inch -tough rubber shell for a stellar grip -strong interior wire holds its shape -for use indoors, outdoors and in any kind of weather
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