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Benchmark and data visualization of German public listed companies in the Integrated Freight & Logistics Industry, with top companies, stocks performance comparison, competitive analysis, and comparisons of top companies for market research.
Germany Integrated Freight & Logistics public listed companies: 2
|Company||Market Cap (USD)||Country||Sector||Industry|
|Deutsche Post AG||$45.40 B||Germany||Industrials||Integrated Freight & Logistics|
|Mueller - die Lila Logistik AG||$52.2 M||Germany||Industrials||Integrated Freight & Logistics|


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Safe Haven, the love story based off of the book by Nicholas Sparks, premiered on Valentine’s Day. Erin Tierney (Julianne Hough) leaves her abusive, alcoholic husband and changes her appearance hoping to start fresh. She ends up in the small town of Southport, North Carolina and adopts the identity of Katie. She befriends a widower Alex (Josh Duhamel), his two children, and a neighbor named Jo. She moves into a small cabin in the woods where she hopes her husband won’t find her. But little does she know, her husband is using all his resources to find her. Her husband is a detective for the Boston Police Department, which gives him the ability to track her down. Meanwhile Alex and Katie fall in love with each other, until Alex finds out she’s not who she says she is. Once Alex knows the truth behind Katie’s past it only makes him more protective of her. Then on the Fourth of July, Katie’s drunk husband shows up in Southport, trying to set the place where Katie is on fire. She stops him but that’s when the unthinkable happens. There are so many horrible things happening at once, and you don’t know if everything will end happily. The ending is full of twists and turns that seem to come out of the blue, but everything falls perfectly into place.
I’m not exaggerating when I say Safe Haven is the best movie I have ever seen. It’s funny, sad, dangerous, and heartfelt all at the same time. I’ve been told this is one of the few movies that actually lives up to the book. Josh Duhamel and Julianne Hough’s romance feels so real, and it’s like you know each and every character personally. The movie is full of surprises and the end is shocking. It’s perfect for couples, teens, and everyone in between. Many men may be reluctant to see it because it’s just another “chick flick”, but there’s definitely enough action and suspense to satisfy everyone. I promise you, the ticket is worth every penny.

domain: artistic


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Shore Excursion: Private Singapore City Highlights Tour
OverviewDiscover the story of Singapore and its fascinating rise from a humble fishing village to a modern economic powerhouse. Chug across Singapore River on-board a traditional bumboat, snap photos at Merlion Park and Marina Bay Waterfront, take in the glittering scene of the city's biggest commercial center on Orchard Road and wind down in the beautiful Orchid Garden.
- Perfect introduction for first-time visitors
- Informative, friendly and professional guide
- All entrance fees included
- Free port pickup and drop-off included
Know More about this tour
Explore the history of the tiny nation of Singapore - referred to lovingly as the Little Red Dot.
We start your adventure by hopping on-board a traditional bumboat, a humble mode of water transportation that has operated both to ferry goods and people across Singapore River for decades. We cruise down the river to Merlion Park, home to a magnificent statue and water fountain shaped as the mythical creature. Take in beautiful views of Marina Bay waterfront and snap a few photos at the iconic statue before heading down to the Civic District.
Wander through boulevards around the Civic district lined with historic buildings before continuing down Orchard Road, a chic shopping avenue thats the beating heart of Singapores glitzy commercial center.
Finally, head to the nearby National Orchid Garden to relax and spend time here exploring the gardens 60,000 plants and orchids and keep an eye out for the countrys national flower, Vanda Miss Joaquim, before heading back tothereturn transport to the Singapore cruise terminal.
Inclusions for Shore Excursion: Private Singapore City Highlights Tour
- Private tour with professional guide
- Entrance fees
- Bottled water
- Port pickup and drop-off by air-conditioned minivan
Exclusions for Shore Excursion: Private Singapore City Highlights Tour
- Food and drinks
Confirmation will be received at time of booking, unless booked within 7 days of travel. In this case confirmation will be received within 48 hours, subject to availability
Children must be accompanied by an adult
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- Private Ho Chi Minh City Departure Transfer: Hotel to Airport

domain: travel


Shannon Has Explained Why He Was Papped Back In ‘The Bachelorette’ Mansion
Shannon Karaka broke our hearts a little last night, making a very gracious exit from The Bachelorette during hometowns.
After introducing Becky to his family, Shannon’s brothers told Becky that they had never seen him so happy, only for Becky to get upset realising she wasn’t in the same place as Shannon. It was pretty heartbreaking viewing, with fans of the show feeling for both Becky and Shannon in that moment.
In his trademark positive form, Shannon comforted Becky, saying he was happy for her that she’s found love with someone else.
— #BacheloretteAU (@BacheloretteAU) October 29, 2020
Shannon was an early frontrunner in the race for Becky’s heart, winning time on the Country Rose date and establishing a strong connection early on. Also, who could forget this moment? I watch it on repeat about three times a day.
However, Shannon never got a second date and while he won the Daddy Daycare challenge (luckily it wasn’t awarded based on mopping talents), it was all too little, too late and their connection halted.
We spoke to Shannon about his time on the show, why he was spotted heading back into The Bachelorette mansion, and on Osher’s wish to make him the 2o21 Bachelor.
On getting over Becky:
“It’s been a bit of time since then and we haven’t spoken at all, so I’m over it now. But at the time, it was disappointing and I was gutted but who am I to get in front of her falling in love with someone else? That’s how I feel. I just appreciate how hard it is to find your one, and she found it in somebody else. I’m happy for her, it’s all good!”
On whether he was approached to go on the show or applied himself:
“The experience just came about, and you know what, I’m single and I’ve been single for a little while, and I was just open to finding a partner. You know, I had a goal on my mind, I want to have a family, I’m 31. I just thought why not, it’s a unique experience to be part of.”
On being greeted by two beautiful blondes on the red carpet:
“I was so shocked there were two girls there, it took me a few seconds to register. My initial first impression, I spoke to both, they were both lovely. I wanted to base it off who I felt a stronger connection with after our first chat. With Becky, we had such a good connection from the first time we spoke. I said she had a sweet spirit and that was my first impression of her, and she nearly cried when I said that. From that point onwards it was just her and I. And we had an amazing first date, and first kiss, and it was all just really good!”
On what we didn’t see:
“There was extra time with Becky that I got that wasn’t shown, and I had a lot of really beautiful moments with her at the cocktail party and some of those weren’t shown either. That’s how the feelings really developed. A lot of it was off-camera, but my feelings were definitely there.”
On why he was papped sneaking back into the mansion:
“I think, you know, how it panned out, it wasn’t meant to pan out like that. Technically you’d go to a rose ceremony. But me going back to the mansion was going back to shoot things I was supposed to shoot that day, because the rose ceremony was meant to be that evening. So I had to be back there because there was also exit interviews I had to do as well. So there’s no plot twist or anything like that! It was just me going to do some shoots and interviews!”
On his Home and Away cameo and whether acting is in his future:
“I think calling me an actor is a bit of a reach. But I was on Home and Away for one episode, it was only a few seconds. It was a cool experience! Would I do something like that in the future? Look after doing this, I had such a lovely time, in the future I wouldn’t say no. Blood and sand, you know? [laughs]”
(Editor’s note: Here’s something we mocked up earlier.)
On whether he’d be the 2021 Bachelor:
Ok – Shannon for Bach 2021. There I said it. Mr Polynesia, let's go. I'll fire up the steamer and get the tux ready if you want it. #BacheloretteAU
— Osher Günsberg (@oshergunsberg) October 29, 2020
“I mean, after this experience definitely, I had such a good time. The girls were amazing, meeting everyone on the show, everyone was just so lovely. And also I had so many nice experiences for myself, I learned a lot about what love means to me and what I’m looking for in a partner. I feel like now more than ever, I’d be so ready to find somebody. I mean, if it happens, I’d be open to it for sure.”


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Impiety To Release New Album "Ravage & Conquer" Through Pulverised Records
Singaporean blackened warbeasts Impiety are set to unleash their eighth studio album through Pulverised Records this May. Offering up eight grisly tracks, including a cover of Bathory’s “Sacrifice,” the aptly titled "Ravage & Conquer" was recorded, mixed, and mastered over a course of two weeks at Studio 47 in Singapore and features cover art by renowned illustrator, Lord Sickness (Sabbat, Witchaven, Zygoatsis, etc), viewable at this location.
The track listing is as follows:
1. Revelation Decimation
2. Ravage & Conquer
4. The Scourge Majesty
5. War Crowned
6. Legacy Of Savagery
7. Salve The Goat
8. Sacrifice (Bathory cover)
"Ravage & Conquer" will be released in North America via Pulverised Records on May 8th, 2012.
Please share this article if you found it interesting.
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In an account of his second “wrong question,” detective’s apprentice Lemony Snicket investigates the disappearance of a young brilliant chemist. With the help of his wacky chaperone, an aspiring journalist and two boys who work together operating a taxi, Snicket uncovers a tangled plot stretching far beyond the simple disappearance of a girl. Far away, his sister faces her own trials, and Snicket laments not being able to help her. Could it all be connected to the vicious Hangfire and his evil plot?
Once again, author Lemony Snicket charms readers with tongue-in-cheek narrative and a hilarious cast of characters. Snicket challenges readers’ vocabulary by including complex words and often defining them within the narrative. It’s a nice way to introduce new words. My daughter and I read both the first and second books in this series together, and she can’t wait to read the next one. We started the Series of Unfortunate Events, and she really likes those books, too, but The Wrong Questions books are a little bit lighter and still have the same kind of humor and silliness. The series has a really unique feel that’s part detective noir and part quirky fantasy. This would make a great summer read, though I recommend starting with the first book.
Brief references to violence. A woman is said several times to be “very good with a knife.” In one slightly creepy scene, Snicket discovers a room with small beds that have manacles attached to them – as if someone is planning to imprison children and experiment on them. Later, Snicket sees a person-shaped hole in a window, which someone has been shoved through.
An apothecary uses laudanum to keep an adult couple in a stupefied state.

domain: entertainment


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After a three-year break, Hello Wood’s builder festival returns to welcome students, architects, and young professionals from all across the world to join the 10-day builder camp to test their wooden construction abilities, learn to collaborate, and participate actively in on-site design and construction. For the first time in Hello Wood’s 13-year history, this year’s workshop takes place at a new location, in the crater of an abandoned basalt quarry on Haláp Mountain in Hungary. The workshop also aligns with and supports Veszprém’s title of 2023 European Capital of Culture, which also includes over a hundred other villages and towns across the Bakony-Balaton region. The event took place between July 6 and 15, ending in a two-day music festival open to all.
Reflecting its unique location, the overarching theme of the workshop is focused on the balance between building and demolition, as the wounded landscape demonstrates how the extraction of building materials inevitably leads to the demolition of natural structures. By highlighting this ecological condition, the event also aims to raise awareness of this location, defined by the naturally occurring hexagonal basalt columns and expansive views of Lake Balaton and its surrounding mountain range. To activate this space, the Hello Wood team also built their own pavilion prior to welcoming the workshop participants. Resembling a campfire, the triangular-shaped structures are built with reclaimed wooden beams recuperated from the site of the Ballet Institute of Budapest.
Beyond the theme, the workshop is an opportunity for students to test out their accumulated architectural knowledge in a practical manner. The workshop is based on Hello Wood’s Builder Method, an alternative educational methodology. Through the process of building structures with their own hands, the participants gain a different type of knowledge while also building a community and developing their confidence and understanding of construction processes. Prior to the opening of the festival, team leaders have been selected based on the creativity and viability of their proposed designs. A call for participants then gathers students and architects to join each team. During the first seven days of the festival, they build the proposed structures coordinated on-site by the team leaders and under the guidance of Hello Wood’s crew. The resulting pavilions and installations demonstrate design thinking rooted in processes and experimentation.


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Regarding laminate flooring fitters, the expertise of Laminate flooring specialists Brixton is paramount. The professionals at Best Flooring Fitters London have established themselves as the go-to experts in the industry, known for their deep knowledge, exceptional skills, and commitment to delivering outstanding results. Choosing laminate flooring specialists in Brixton ensures that your flooring project is in the hands of professionals dedicated to transforming your space with elegance and precision.
Best Flooring Fitters London possesses an in-depth understanding of the intricacies of laminate flooring. They have extensive knowledge of different types of laminate, finishes, and installation techniques. Their expertise enables them to guide clients in selecting the most suitable laminate flooring options based on their preferences, budget, and intended use.
One of the key advantages of working with Best Flooring Fitters London is their ability to provide tailored solutions. They take the time to assess your needs and requirements, offering customized recommendations aligning with your vision. Whether aiming for a rustic look, a modern aesthetic, or something in between, these specialists can help you achieve the desired outcome.
Furthermore, Best Flooring Fitters London possesses excellent technical skills. They are well-versed in the intricacies of installation, ensuring that the laminate planks are laid with precision and care. Their attention to detail guarantees a seamless and visually pleasing finish with no visible gaps or inconsistencies.
In addition to their technical proficiency, laminate flooring specialists at Best Flooring Fitters London prioritize customer satisfaction. They strive to create a positive and hassle-free experience for their clients, from the initial consultation to the final installation. Their professionalism, clear communication, and deadline commitment ensure the project runs smoothly and efficiently.
Best Flooring Fitters London also understands the importance of providing long-lasting solutions. They work with high-quality materials and employ industry-approved installation techniques to ensure that your laminate flooring looks beautiful and remains durable and resilient for years.

domain: design


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Take-Two Interactive Software announced that all of the class action lawsuits pending in the U.S. against it and...
Nov 9 2007, 10:46am CST
YOU might think GTA V is the greatest thing since sliced ham, but the game’s Lacey Jonas character has got Lindsay Lohan in a spin alright.
Lacey is a blond celebrity who lives at the Chateau Marment on West Hollywood who is trying to escape the paparazzi all the time and isn’t exactly a virtuous human.
Lindsay Lohan, meanwhile is… well… draw your own conclusions because we don’t want to get involved with her lawyers. Her lawyers a like those badass TV ones. Our lawyers are li ...
Full article at: Anorak
Jul 4 2014, 1:46am CDT
Source: The Business Insider
Lindsay Lohan has filed a lawsuit against the makers of the "Grand Theft Auto V" video game. In the suit, Lohan claims that character Lacey Jonas is an “unequivocal” reference to the actress, depicting her image, voice, and styles from her clothing line. The game even shows the character avoiding paparazzi outside of the Chateau Marmont Hotel, where Lohan once lived. When Lohan initially started to craft the lawsuit in December...Many ass ...
Full article at: The Business Insider
Jul 3 2014, 12:53pm CDT
Source: Latino Review
Lindsay Lohan filed suit against Rockstar Games and Take-Two Interactive Software on Wednesday in New York City, saying the creators of “Grand Theft Auto V” used her image to create a character based on her without permission. Rumors began swirling just seven months ago that Lohan was p ...
Full article at: Latino Review
Jul 2 2014, 5:45pm CDT
Lindsay Lohan filed suit against Rockstar Games and Take-Two Interactive Software on Wednesday in New York City, saying the creators of “Grand Theft Auto V” used her image to create a character based on her without permission. Rumors began swirling just seven months ago that Lohan was planning to take legal ...
Full article at: variety
Jul 2 2014, 5:39pm CDT
Source: Oh No They Didn't!
The next generation of consoles is starting to shake up the sales charts.With the release of the PlayStation 4 and Xbox One, there's a new mid-year sales leader in the videogame industry—and it's not Call of Duty for a change.9) inFAMOUS Second SonIt's proved so popular that it was credited with doubling PS4 sales in the UK during its first week—and sold 1 million copies in just nine days.8) Assassin' ...
Full article at: Oh No They Didn't!
Jun 9 2014, 11:13am CDT


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Here are some further details about the shooting of Death or Canada
Casting took place in Westport Co Mayo to find the Willis Family - John and Mary Willis and their five children. Rose Conway was cast as Mrs Mary Willis and Tony Murphy as Mr John Willis. Three of the actors who played the Willis children and many of the other cast members and extras had relatives who had survived the famine and were able to recount stories of starvation and humiliation that had been passed down through their families. Achill was one of the worst affected areas during the famine, and filming famine scenes on the island had a profound and lasting affect on the cast and crew. Our Irish Production designer was Cos Egan ('Garage', 'Count of Monte Cristo', 'Saving Private Ryan'), make up Morna Ferguson ('Old Curiosity Shop', 'My Boy Jack', 'Middleton') and wardrobe designer Lynne Williams ('Cromwell in Ireland', 'King Arthur').
Director Ruàn Magan, DOP Colm Whelan, actors Tony Murphy (Mr. John Willis) and Rose Conway (Mrs. Mary Willis) flew to Toronto to film the scenes of the Irish famine ships arriving in Grosse Isle, Canada, hundreds of immigrants being vetted by Canadian doctors, and the fever sheds and hospitals of Toronto where thousands of Irish died. The Canadian production crew and cast numbered 160 in total. Included in the Canadian crew were Production Designers Rocco Matteo (Interstate 60, The Scarlet Letter, My Big Fat Greek Wedding) and Jennifer Jacobson (American Psycho, Dark Water, Time Travellers Wife). The Canadian crew were hugely enthusiastic about the project, realising that they were bringing back to life a story that been hidden under the streets of Toronto for 150 years. They were commemorating the thousands of Irish Famine victims who died in Toronto but also celebrating the extraordinary Canadian men and women who were responsible for selflessly saving thousands of Irish emigrants from starvation, sickness and death.
The programmes also follow the intriguing progress of the present day archaeological excavations on the sites of the fever sheds, famine hospitals and burial grounds where these immigrants died and were buried. There is a sense of high drama as archaeologists anticipate what the digs might uncover about a story that has, literally, lain buried for 150 years. Under the expert guidance of Canadian historian Mark McGowan and chief archaeologist Ron Williamson, we filmed these excavations and combined archaeological and historical evidence to piece together the story of the terrible summer of 1847. Using clues from recovered artifacts, ships manifests, newspaper clippings, diaries and burial records, Mark tries to determine what happened to the people who perished and those who survived.
Acme Pictures in Toronto created the CGI scenes depicting the mayhem at Limerick Docks in 1847, the famine ships arriving in Grosse Isle Canada that same year, and the hundreds of steamers and liners at Toronto docks as the Irish immigrants make their way up St Lawrence River. Seamless CGI scenes were also created to replicate the hundreds of fever sheds and the Toronto hospital that housed the sick and dying Irish.
Death or Canada is an Ireland-Canada Co-Production produced by Tile Films (Ireland) and Ballinran Productions/Summer of Sorrow Productions (Canada) for RTE, Canwest Broadcastings, History Channel UK with the participation of the Sound and Vision Broadcasting Funding Scheme, The Canadian Television Fund, the Canadian Film or Television Production Tax Credit and the Ontario Media Development Corporation Film and Television Tax Credit.

domain: history


The High-low are hosted from the British writers Dolly Alderton and you will Pandora Sykes and you may discusses pop-culture, development and you may items impacting to the ladies. I hang out of these symptoms and you can I’m constantly happy whenever an alternative you to drops. It’s great to know eg innovative talks with the very important (and you will frivolous) items nowadays, particularly taking perspectives regarding wise lady of a different country. (And https://www.datingranking.net/cs/omgchat-recenze a keen honourable talk about goes to Dolly’s other podcast Love Stories that have Dolly Alderton).
Everyone loves just how it podcast produces me end up being confirmed in a beneficial method regarding the my passion for this new ‘stupid stuff’ in daily life
Chat ten Seems 3 try managed of the Australian journalism royalty Annabel Crabb and you will Leigh Sales. I really like this podcast because it is genuinely such as for example paying attention to your the latest talk of a couple higher friends who along with simply accidentally become a few of the foremost voices of Australian governmental journalism. Crabb and you can Conversion (as they alternatively affectionally consider each other given that) chat all things guides, dining, shows and you may video that will be a look for the thoughts about this type of higher Australian females.
It’s fantastic to own several practical Australian ladies putting their sounds nowadays and i also like performing my personal Saturday day having a new episode of so it podcast
Bang For the are organized because of the Myf Warhurst and you may Zan Rowe, brands that will be common to you personally if you have ever listened so you can Multiple J! It talk about audio, clips, instructions, pop-community as well as points that is actually interesting them recently and it’s merely including a fun podcast and you may chat anywhere between loved ones.
After finishing up work Beverages are organized of the reporters Isabel Truman and you may Sophistication O’Neill and contains for example a fun mood. It is other pop-people podcast that’s capable explore pop society and you may star goings-on from lens out-of wise conversation and make use of the brand new subject areas given that a catalyst to generally share huge circumstances.
The real history Girls is actually a fairly novel podcast certainly one of that it listing. Managed from the one or two amazing females, Susan and you can Beckett, per episode deep dives for the a female of records who you might not know away from. It’s better researched and you may interesting and you may provides this new stories of these people alive in a manner that history guides rarely manage.
Wardrobe Drama is a great podcast by Fashion Australia’s Sustainability Editor, the incredible Clare Press. If you’ve ever wanted to know more about durability and ethics popular, and just how it is possible to make a difference, upcoming this is actually the podcast for your requirements. Clare has some other traffic weekly (only 1 off one or two implies that create inside listing!) as well as all features other plays new numerous points in renewable style however, are all functioning towards the preferred purpose off a much better business and sustainable strategies in fashion.
The Responsible Feminist is organized from the Deborah Frances-Light and is the second rotating visitor podcast on this subject listing. Per week, Deborah invites comedians, activists, writers and you can (mostly) girls of a varied a number of experiences and existed sense in order to explore a specific question and just how it could be appeared on from an enthusiastic intersectional feminist position. It’s funny and also considering me personally a great deal to take into account with respect to feminism and just how We frame my viewpoint, words and conduct.
Upright and you can Curly try an excellent podcast currently to the nothing hiatus however, discover a huge list off periods if you’re new to the brand new podcast. Hosted by the Carly Jacobs and you may Kelly Exeter, so it podcast is mostly about yields and you can lifetime upgrade. Obtained secured topics such as form solid limits, reframing problem, cellular telephone dependency therefore the four burners idea. It’s good podcast if you are looking to acquire some more framework inside your life and seeking to have a means to overcome particular of your problems that everyone face.


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Age Of Transparency is said to be the second in a trilogy started by Anxiety. Inspired by the marketing ethos where brands seek to portray themselves as human, flaws and all, the album's lyrics deal with self-presentation, internet addiction, social media and, of course, relationships. Ashin claims it's a less personal album, but Transparency is unmistakably a product of his psyche, exploring familiar themes in his inimitably hard-to-parse stream of yelps and howls.
The album picks up right where we left Ashin, with an extended reprise of 2013's one-off single "On & On." That one had the plasticine sheen of Anxiety, while the reprise is disarmingly spare, signalling the new direction ("World War" also gets a fussier sequel). Ashin's voice is left alone to climb unpredictable scales and veer through odd turns, while bits of the session recordings flicker and burst below. Jazz informs Age Of Transparency in more ways than one—the genre is one of Ashin's earliest musical influences, and you can hear its improvisational nature in his vocals and fractured songwriting. Where Ashin once strung together pop hooks, here his voice acts like an artist violently lashing paint against a blank canvas.
On tracks like "World War Pt. 2" or "Cold Winds," vocal melodies slip in and out of lucidity, pulling you in with a hook and then darting off in another direction. Tracing his jagged lines takes concentration, and it makes Age Of Transparency less approachable than Anxiety. Ashin often seems to sing at you rather than for you, and he rarely lets up. Things snap into place in some moments. "Panic Room" shows Ashin's pop genius in full splendour, while the beautiful title track starts as an ambient wash and develops into one of his most elegant songs—the backbeat, built from a choir and fluid orchestral accompaniment, thrashes and settles with his voice.
Ashin pulls apart and reconstructs his recordings until they no longer sound real, and the arrangements seem to burst and glitch at random. No sound is left untouched, which is Age Of Transparency's most impressive and most impenetrable aspect. It's a new level of inscrutability from an artist whose work already felt dense. The approach is fitting, though: Transparency sounds as obsessive as the person who made it. Ashin has a singular talent, and grows more idiosyncratic as he takes his compositional style to extremes. The result is an album split between brilliant and head-scratching moments, and it's all a lot take in at once. Anxiety dressed up Ashin's neuroses in glossy textures, while Age Of Transparency lets them writhe all over the floor. Like his live show, it's thrilling, confusing and uncomfortable in equal measure.


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Since a headache is one of the first and most common signs of brain tumor, it is important to find out and know more about brain tumor headaches. Headaches are commonly caused by stress, sleep problems, vision problems and many other reasons, but those that are caused by brain tumors can have certain features that differentiate them from regular headaches.
Recognizing brain tumor headaches
When a person has headaches it is important not to jump to the conclusion that its brain tumor that causes it, because brain tumors are actually not at all common. It is also important to remember that all brain tumors do not cause headaches and this may be a symptom only in some half of all with brain tumors.
There are many other causes of headaches. When a brain tumor occurs, it places pressure on the inside of the skull resulting in a headache. There could be swelling of the brain, and fluid accumulation that could also cause the headaches.
Characteristics of brain tumor headaches
Though we speak of a ‘typical’ headache caused by a brain tumor, the fact is that brain tumors can vary very greatly from person to person in terms of location, size, nature and type of tumor. In the event some people have these characteristic headaches, some have other types of headaches, and yet others don’t have headaches.
Headaches that are caused by a brain tumor are most commonly better or worse at particular points during the day. The morning headache that eases up during the day is thought to be a characteristic of the sort of headaches caused by brain tumors.
Often the pain of the headache may be severe enough to rouse the person from their sleep. This quality of headaches; which can actually awaken someone due to their severity may be a warning sign.
It could be a dull or throbbing kind of ache and very often brain tumor headaches may not be too severe or excruciating enough to be debilitating.
Another characteristic of a brain tumor headache is a progressive worsening of the headache and an increase in its frequency. It could become as frequent as to become almost a constant situation.
Lack of responsiveness to common pain relieving medication available over the counter that is usually effective against headaches is another characteristic of this type of headache.
Certain positions or actions can worsen brain tumor headaches. Lying down, or shaking the head can do this. Sneezing or coughing could also exacerbate the headache because of the pressure generated by these actions.
Whether or not it is a brain tumor that is causing the headache can be determined by looking at the person’s history of headaches. There could be certain predictable triggers that cause a headache when it is related to a brain tumor. There are also typically other symptoms that accompany a headache caused by a brain tumor.
The pattern of the headache’s occurrence, its location, the severity of the pain, its responsiveness to medications could all be pointers and would help in identifying brain tumor headaches.

domain: health


President of the PNG Trade Union Congress John Paska has called on the government to set up a conflict resolution committee to thoroughly investigate the Alotau stand-off between police, civilians and criminals.
He said the committee would be tasked to thoroughly canvass the issues that gave rise to the stand-off and make relevant recommendations on the measures to resolve the stand-off.
He proposed the high-powered team to be headed by a National Court judge. “The matter is too complex and delicate to be left to the hands of a few policemen to resolve through gun barrel diplomacy,” Mr Paska said
“Gun barrel diplomacy never works. It was employed in Bougainville and failed resulting in the most costly and disastrous conflict in PNG history.
“The distrust between police and civilians in Alotau is deep seated such as even if ring leader Baker is captured or shot, the wound will continue to fester and reappear down the line if not properly resolved.
“I recently returned from Alotau and it is clear civilians have been drawn into the conflict are not supportive of the government heavy-handed tactics.
“It is also apparent Baker has become some kind of folk hero. So what he is doing that’s attracting the civilian sympathy despite criminal indictments.
He said the government has casually painted the entire issue as just another criminal matter ignoring the fact that human rights has been a casualty of the fracas.
“This is gross miscalculation. The fact is there is enough blame to be shared by all parties to the conflict particularly with regards to human rights abuse,” he said.
“The PNGTUC does not condone human rights abuse and injustice neither does the public. We insist those caught in the crossfire including relatives of police personnel be fairly compensated and those responsible be made to account,” Mr Paska said.


Travis Sayles drops catchy new song ‘Time Awaits’
Travis Sayles is excited to announce the release of his first single, ‘Time Awaits’, which is now accessible on all platforms. Sayles, a producer with more than 2 billion streams, has collaborated with some of the top musicians in the business. This lofi hip hop/chill hip hop/jazz masterpiece is titled ‘Time Awaits’. Layers of Rhodes piano, organ, and piano are used in the song, which also has a hip-hop drumbeat.
Sayles is an American multi-platinum producer, musician, singer, songwriter, and artist also known by his stage name Travesty. He has played with Grammy Award winner Maxwell for 12 years and is currently on tour with him. Sayles’ most recent work includes producing three songs for Chris Brown’s most recent album, ‘Breezy’, as well as the Backstreet Boys’ just-released holiday album, ‘A Very Backstreet Christmas’.
Check out his new song here!


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Antibody responses to antigenic determinants
of influenza virus hemagglutinin.
The RAYS ratios before and after denaturation and the overall distinction between linear and conformational antigenic determinants
of the SARS-CoV N protein are shown in Fig.
Antibodies with specific recognition for specific antigenic determinants
could now be prepared.
This property is especially critical during human pandemics that are characterized by novel antigenic determinants
The development of an antibody-based ELISA test to type haptoglobin has been hampered by the apparent lack of antigenic determinants
unique to either allelic protein product.
While immunologic tests have almost unlimited throughput, the high specificity of these assays may result in failure to identify etiologic agents with different antigenic determinants
To compare with IAPP immunoreactivity measured by another assay detecting different antigenic determinants
, the same samples were assayed by the solid amylin enzyme immunoassay (Amylin Pharmaceuticals Inc) without extraction (4).
The epitopes recognized by certain neutralizing antibodies have been mapped to conformational antigenic determinants
To explain the low sensitivity, it must be considered that anti-CCP antibodies are a heterogeneous group of antibodies directed against different epitopes on the citrulline molecule, that each patient's serum contains different subsets of antibodies, and that the synthetic peptide used in this assay represents a relatively small set of antigenic determinants
that do not entirely encompasses the antigenic determinants
present on the as yet unknown antigenic molecule in the joint (14).

domain: chemistry


text:
The road less traveled
In the early 1980s I came upon a book by M. Scott Peck (1936-2005), an American psychiatrist, whose title intrigued me so much that I delved into it immediately ― I just had to find out what it was all about.
``The Road Less Traveled,” published in 1978, has sold more than 10 million copies. It is a description of the many attributes that make for a fulfilled human being, based largely on Dr. Peck’s experiences as a psychiatrist and a person. This book title reminded me of a poem by the American poet Robert Frost (1874-1963), “The Road Not Taken,” whose last stanza ends: ``I shall be telling this with a sigh, Somewhere ages and ages hence: Two roads diverged in a wood, and I, I took the one less traveled by, and that has made all the difference.”
During 17 years living in a largely Jewish town in northern New Jersey, I was naturally drawn to the subject of anti-Semitism and the Holocaust in which Nazi Germany managed to kill some 6 million Jews. I sought out many books dealing with this subject and one of the most rewarding aspect of that pursuit was learning about the ``righteous Gentiles” who took the road less traveled.
One of them was a young Swedish diplomat named Raoul Wallenberg (1912-1947). He is now remembered for his humanitarian efforts rescuing thousands of Jews in Nazi-occupied Hungary while serving as a Swedish diplomat. Between July and December 1944 Wallenberg issued protective passports and sheltered Jews in buildings designated as Swedish territory saving tens of thousands of lives. Ultimately he died under questionable circumstances that seem to derive from his heroic efforts in taking the road not taken by many people.
Corrie ten Boom (1892-1983) is another good example as a sojourner on this less traveled road. A Dutch Christian, she and her father and other family members helped many Jews escape the Nazi Holocaust during World War II. Her family was arrested because of an informant in 1944, and her father died ten days later in prison. A sister, brother and nephew were released but Corrie and her sister Betsie were sent to the Ravensbruck concentration camp, where only Corrie survived. Corrie ten Boom wrote many books and aided Holocaust survivors.
Her autobiography, ``The Hiding Place” (1971), about her experience of rescuing Jews in Holland, is one of the most moving stories I’ve ever read. I continuously asked myself while reading it, ``Would I be able to do what Corrie ten Boom did if I were put in the same situation?”
One Korean from our history comes to my mind as a good example as one who also chose to travel on the road less traveled. Jeong Mong-ju (1337-1392) was a civil minister and scholar during the late Goryeo Dynasty (918-1392). After Yi Seong-gye revolted against the Goryeo Dynasty in order to found the Joseon Dynasty (1392-1910), Jeong Mong-ju was murdered by Yi Seong-gye’s fifth son Yi Bang-won (later King Taejong of the Joseon Dynasty) because he refused to collaborate with them in the coup and persisted in his loyalty to the Goryeo dynasty.
Jeong Mong-ju’s poem of loyalty has been taught at Korean schools as inspiration for faithfulness. Even now when I recite it I get a lump in my throat.
Though I die and die again a hundred times,
That my bones turn to dust, whether my soul remains or not,
Ever loyal to my Lord, how can this red heart ever fade away?
One of our cousins was leading a comfortable life teaching at a prominent university as a tenured professor of psychology. He always had a deep longing to paint full-time. Even knowing that if he followed his heart he would suffer financial insecurity, he chose what made him happiest. He didn’t want to come to the end of his life filled with regret for not taking the road his heart was beckoning him to follow.
On a personal level, I too took the road less traveled by marrying a non-Korean in 1970 when doing so brought on many dirty looks, societal disapproval and family disgrace. I am so glad I had the chutzpah to take that road less traveled. Deepest remorse would have followed me all my life if I had taken the easy road.
M. Scott Peck said: ``Life is complex. Each one of us must make his own path through life. There are no self-help manuals, no formulas, no easy answers. The right road for one is the wrong road for another … The journey of life is not paved in blacktop; it is not brightly lit, and it has no road signs. It is a rocky path through the wilderness.”
As 2011 is fading we need to ask ourselves again, ``Is there some fear in me that prevents me from traveling the road less traveled?” I sincerely hope that all of us will have the inner light to lead us on to the right road. May you have the courage to choose the road less traveled when that challenge arises!
Only you will know when that moment is.
Hyon O'Brien is a former reference librarian now living in the United States. She can be reached at firstname.lastname@example.org.

domain: literature


text:
Hair Clips by illustrator Maddie Egremont
This print is currently available in 315mm x 315mm size with an option of an A2 (420mm x 594mm) frame size.
Illustrations are printed on Hahnemuhle Photo Rag 300gsm Fine Art Paper.
All prints are signed by Maddie Egremont.
Prints are available unframed (print only), block mount, or framed (black or white wooden frame).
All orders are custom-made, please allow 5-7 days for production.
Custom sizes, frames, and matboards are available upon inquiry. Please call (02)9212 2669 or email firstname.lastname@example.org for more information.


Grant boosts A11 corridor bus services
Bus passengers are set to benefit from more frequent and greener services following a �2m government investment into a project along the A11 corridor.The Department for Transport has announced that Norfolk County Council will receive the cash that will enhance services between Attleborough, Wymondham, and Norwich.
Bus passengers are set to benefit from more frequent and greener services following a �2m government investment into a project along the A11 corridor.
The Department for Transport has announced that Norfolk County Council will receive the cash that will enhance services between Attleborough, Wymondham, and Norwich.
The financial boost from the government's Kickstart scheme will help fund a service between Attleborough and the city every 20 minutes and a direct bus between Wymondham and Norwich every 10 minutes from Monday to Saturday.
Officials from the county council welcomed the investment, which will also pay for low carbon buses using dual fuel diesel/biogas technology.
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The A11 corridor project was one of four areas in the east of England to receive �15m from the Kickstart scheme, which had been rumoured for the axe under government funding cuts.
The �2m is almost �800,000 short of the sum asked for, which will mean that County Hall officials will shave some of the costs of the scheme. However, the project will still offer journey time savings and significant passenger growth on the routes.
- 1 New Toolstation branch coming to Wymondham?
- 2 Norfolk yet to reach peak in latest wave of coronavirus deaths
- 3 £4.8m funding to tackle scourge of drugs in Norwich
- 4 Timeline: When should you receive the coronavirus vaccine?
- 5 Date for museum's reopening 'pencilled in' after missing whole 2020 season
- 6 Egg and Spud Man's delivery service booms in lockdown
- 7 Tree falls on rail line as winds up to 69mph hit Norfolk
- 8 Covid cases fall in every area of Norfolk for first time since June
- 9 Specialist exercises for 'less mobile' during lockdown
- 10 Council agrees u-turn on churchyard grass cutting
Adrian Gunson, cabinet member for planning and transportation at Norfolk County Council, said he was 'very pleased' with the news, which will not result in a reduction in services to the villages around the market towns.
'It is a significant grant to enable us to finance for three years a very frequent service from Attleborough and Wymondham to Norwich, the university, hospital and science park.'
'We have got a good part of what we asked for and we will have to cut our cloth accordingly. I think it is a very worthwhile project. The A11 corridor is a growth area and Attleborough and Wymondham are two of our larger market towns,' he said.
The Kickstart programme offers financial backing to help launch new or improved services, with the focus on getting more people on the buses as well as improving accessibility.
Transport minister Sadiq Khan said: 'Some bus services which could provide an important transport link might not always be commercially attractive from the outset. This will help fund new and improved bus routes, ensuring local people get the services they need.'


text:
SOCAR RUS LLC was established in accordance with the legislation of the Russian Federation in 2013. Since 2016, the company has been accredited at the St. Petersburg Stock Exchange to be eligible to participate in oil, petrochemical and liquefied petroleum gas (LPG) exchanges. In 2017, SOCAR’s Russian subsidiary, which has already become an active participant in the exchange, began selling low-density polyethylene, LDPE.
Thus, since the 7th of April 2017, SOCAR RUS has been selling 15803-020 LDPE produced by Azerkimya in the local market. Since 2019, the company has also been selling PP and HDPE produced by SOCAR Polymer in the Russian market. The product is delivered to Russia by road, sea and railway.
In addition, the company trades in oil, liquefied gas, naphtha and other raw materials in the local market and also has an opportunity to promptly deliver various petrochemical products, including ethylene benzene fraction, aluminium chloride, ethylene glycol, various alcohols, mineral and synthetic petroleum oils, petrol, kerosene, aviation fuel, fuel oil and other products to customers in any quantity.


text:
Made from high-quality materials, this shoulder bag is built to last. Its sturdy construction ensures that it can withstand daily wear and tear, while its spacious interior provides ample room for all your belongings.
Whether you're heading to work, running errands, or going out for a night on the town, the Chic Crackle Style Tote Handbag is the perfect accessory to complete your look. So why wait? Order yours today and experience the ultimate in style and functionality!
Having a handbag which offers a unique look which is also very stylish is something all women want. You can get all of this by having this bag as part of your collection. It is a bag which is made of a sturdy leather which has been given a crackle style look and texture. This helps to boost the unique design elements it features. The sides of this chic styled tote has been flared. This gives it a hop look and also offers more compartment room. Large matching leather handles have been sewn onto each panel of the bag, They are design into large matching leather pouches. An accent envelope flap with a a metal accent accent has been added to the upper middle of the front panel. This bag also has removable shoulder strap. Get this bag in the color options of black, mauve or rustic blue.


text:
Tide lineup still jumbled
Published: Friday, February 6, 2009 at 3:30 a.m.
Last Modified: Thursday, February 5, 2009 at 10:56 p.m.
TUSCALOOSA | When she stuck the landing, the look on her face said it all: Joy, surprise and excitement. Yeah, it was a good feeling.
“Then my score came up and all my teammates were so excited for me,” University of Alabama freshman gymnast Rachel Terry said about her 9.9 on the vault last Friday at Arkansas. “It was a lot of fun.”
Now comes the hard part. Doing it again.
Tonight, when No. 19 Denver visits the Capstone, Terry and a number of other Crimson Tide gymnasts will likely get their chance to contribute thanks to the lineup being more in a state of flux than ever.
While the team is lamenting the loss of senior Brittany Magee, who is out for the rest of the season due to a knee injury, it’s simultaneously enjoying the return of a number of key contributors who are being eased back into competition.
If it sounds confusing, well, even some of the gymnasts are having a tough time keeping up with all the coming and going.
At Arkansas, Alabama had 11 different gymnasts compete for the third time this season. Half of the Tide’s 24 events were performed by someone who wasn’t in the lineup prior to this season, including nine by freshmen like Terry.
That number could actually go up against Denver – which is led by Jessica Lopez, ranked No. 2 nationally in the all-around -- should Caitlin Sullivan compete in floor exercise.
“We’ve had a lot of adversities, a lot of letdowns in terms of injuries,” Terry said. “In the last meet we didn’t have Brittany and everyone really had to step up. I had to compete bars (too), but it’s been really amazing to see everyone step up and the encouragement everybody’s offering each other.
“It’s brought us closer together, it really has.”
Magee, who along with juniors Morgan Dennis and Ricki Lebegern competed in the all-around, sustained the injury while completing a landing on floor exercise during practice, joining junior Jacqueline Shealy (knee) on the sideline.
However, junior Casey Overton (shoulder) returned on the beam at Arkansas and senior Ashley O’Neal (ankle) competed for the first time this season on floor and scored a leadoff 9.8. With Dennis and freshman Ashley Preiss scoring a pair of 9.9s, the Tide went on to score a season-best 49.275 despite it being the team’s weakest event.
“Exceptional,” Patterson said about O’Neal. “It was really exciting to have her back for us.”
Sophomore Kayla Hoffman (shoulder), an All-American on vault, warmed up with the team at Arkansas and may attempt a toned-down exhibition on bars against Denver. She’s likely still a week or two away from returning to competition.
Thus, the opportunities will continue for teammates like Terry.
“Sometimes Rachel struggles in practice and boom, she hits in a meet setting,” Patterson said. “She had the most surprised look on her face, ‘I’m so surprised my feet aren’t still moving,’ at the end of her vault.”
The vault was a Yurchenko full, and greatly improved from her 9.675 score at Georgia the previous Friday.
“You run down the runway and you put your hands on the mat before the board and do a round-off on to the board, and then like a back handspring up on to the horse, then a layout flip with a full twist,” Terry described. “If done right, it looks cool.”
Reach Christopher Walsh at email@example.com or at 205-722-0196.
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domain: news


text:
SOUND OFF: Should euthanasia be legalized?
A Texas man wants Euthanasia legalized in Texas.
His 21-month-old granddaughter was sent home to die after being given a 4 percent chance to live.
He watched her die for nine days after the feeding tube was removed.
He says withholding hydration and nutrition is inhumane.
As controversial as it may be, he now sees euthanasia as compassionate.
Do you think Texas should legalize euthanasia?


The Aspen Skinny \\ March 31, 2017
Aspen Land-Use Code Changes, Explained
When a yearlong moratorium on new development applications in Aspen’s commercial core expired on March 17, a series of far-reaching land-use code changes went into effect. The code tweaks, which consumed many an Aspen City Council meeting for over a year, apply to building heights, free-market residential uses, downtown commercial mix, parking, affordable housing mitigation, and more. Council even tinkered with what kind of stores to allow in Aspen. It’s the most extensive rewrite of Aspen’s land-use codes since the “infill” regulations of the early 2000s loosened them. Here’s your guide to what’s changed.
Free-Market Residential Ban
Ordinance 29 bans new free-market residential units in any area of Aspen where commercial uses are allowed. The new rules broaden the scope of a policy that started down this road in 2012, when City Council prohibited upper-floor, free-market residential units in the central core (CC and C-1 districts). The thought was that developers were constructing or redeveloping buildings in order to sell expensive penthouses, with little attention to the viability of the commercial components. Finding that the trend was also playing out beyond the commercial core, council this year approved extending the free-market residential ban to the city’s outlying commercial areas, which include the Service/Commercial/Industrial (SCI) and Neighborhood Commercial (NC) zones. In the Mixed-Use (MU) zone, which stretches along Main Street, residential development is limited to standalone buildings with no commercial uses and must provide an equal amount of free-market and affordable housing.
The move has prompted one developer so far to sue. North Mill Street Investors, which includes prominent local developers Andy and Nikos Hecht, claims in its suit that it purchased the Mill Street Plaza — whose businesses include a secondhand sporting goods store and a laundromat — in order to redevelop it as a mixed-use complex including free-market residential units. The downzoning was “arbitrary and capricious,” the suit claims, and burdens the property unfairly, as it’s the only one in the SCI zone without free-market residential already.
Height Limits Lowered
Another part of Ordinance 29 tackles dimensional standards, most notably height. Maximum building heights have been lowered to 28 feet across the board in the central core (CC and C-1 zones) and all surrounding commercial districts except the SCI zone, which is permitted to have buildings up to 35 feet. Previously, a third story up to 40 feet was allowed in the core, but just on the north side of the street and only for short-term lodging (e.g. hotels). Heights in the outlying commercial zones could previously be increased with special review.
Council also approved changes in dimensional standards that reduce massing by reducing cumulative floor area ratios (FAR) of downtown buildings, essentially reverting back to the pre-infill days on that philosophy.
A brand-new requirement prioritizes “second-tier spaces” in commercial buildings. These are spaces that typically do not command premium rents — they may be subgrade or above the ground floor, or if on the main level accessed by an alleyway or interior courtyard (meaning less visible from the street than a typical storefront). Under the regulations, new commercial development is required to provide at least 20% to 35% of its total leasable area (depending on the zone district) as second-tier space, which theoretically increases the viability for local-serving and mom-and-pop businesses with potentially more affordable rents. Remodels or redevelopments with existing second-tier space must preserve 50% of that in the new development.
Ordinance 33 also increases the amount of pedestrian amenity, or open space, required on a building site.
Affordable housing mitigation has increased. Now, new development must provide housing mitigation for 65% of employees generated, up from 60% in the old codes. Council also eliminated a loophole whereby replacement of commercial buildings that pre-dated affordable housing requirements didn’t generate new affordable housing. Ordinance 31 gradually increases the percentage of housing required for scrape-and-replace projects, starting with 15% and building up by a 3% annual increase until 2034, when housing will have to be provided for 65% percentage of employees generated, like all other new development.
Parking and Transport
With Ordinance 32, parking requirements have been tweaked to encourage alternative transportation. The City has increased the cash-in-lieu mitigation fee for new development, and added an option for some development projects to meet parking requirements with mobility improvements.
For even more detail, the City has produced a guide to the full suite of land-use code changes.
Finally, in a separate but related series of discussions, Aspen City Council voted in early March to establish a new conditional-use review process for “formula retail” in the commercial core and Main Street historic district. What this means is that if a business with at least 11 US locations and meeting certain criteria pertaining to staff uniforms, signs, standardized merchandise and the like, wants to come to Aspen, it’ll trigger a special review process, which would look at criteria such as whether the proposed store brings diversity to the town’s retail mix, for example.
First proposed by an ad-hoc group of local citizens in November 2016, the chain store regulations have spurred fierce debate in and outside of the council chambers, with its proponents — including former mayors Bill Stirling and John Bennett and venture capitalist Jerry Murdock — hosting an all-day symposium on the issue. The purpose of the new rules, they successfully argued to City Council, is to temper the homogenization of downtown from corporate chains that are thought to have more financial wherewithal to sign high-rent leases than smaller and more local-serving businesses.
When council unanimously approved the ordinance on March 6, it was a watered-down version of the initial proposal. The legislation exempts all existing buildings, plus any development in the approval pipeline, so it will only apply to new development yet to be proposed when it goes into effect on April 5.


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text:
This afternoon my Dad and I picked apple and pears and they were quite bountiful. I have never seen a pear tree and I must say, these pears were gigantic! As my Dad said "These things are as big as softballs", and he was right. The pears were not quite ripe, but my wise father told me to wrap them in newspaper and store them in my shed and in a week, they will be ripe enough to eat. We found a few that were ripe enough to eat, so we shared one of the yummy, sweet pieces of fruit. My Mom loves pears and so does my son so I know she will enjoy the harvest.
After the pear tree we headed to the yellow apple tree and picked a few of those to add to our pile. Once we made it to the Red Delicious apple tree all of our buckets were full so Dad could not carry it up the ladder with him. Instead I stood at the bottom while he tossed them down to me. Our bucket was flowing over with the red and yellow fruit so we knew we had to call it quits and leave the rest for others to enjoy.
I love spending time with my Dad (and you too Mom). My son jumps at every chance he gets to spend with PaPa and I know why. He is so much fun to be with and a wealth of knowledge. Dad didn't go to college, but he has far more knowledge and experience than any University can give you. I'm proud to have him as my Dad (and you too Mom)! :) I love them more than anything I have. Thank you God for giving me the best parents known.
Now, I think I need to bake something with this yummy fruit my Daddy and I gathered.

domain: hobby


Snapchat is testing a new feature for creators where it will allow replies to its ‘Spotlight videos’. Spotlight is Snap’s answer to TikTok videos and Instagram’s Reels aka the short video format. The company states that is one of the top-requested features from users. Snaps says the feature will help creators on the platform build their community as well.
The new feature will allow audiences to leave a text reply on a creator’s Spotlight video. The reply is moderated first before being sent to the creator. The creator of the Spotlight video will have the power to control which replies can appear publicly for other viewers to see.
Snapchat also insists this is not like the comments feature that one sees on other platforms. The company states that the feature has been “thoughtfully and carefully designed to bring the benefits of community and connection”. It should be noted that the feature for public replies is only rolling out to the Spotlight segment on Snapchat. This feature is not available on friends’ Stories. Snap notes that public replies to private Stories would “fuel toxic and inauthentic behaviours.”
Regarding the content moderation for these public replies, Snap will rely on “machine learning to proactively moderate the text of all Spotlight Replies”. The ML models will search “for harmful text” which is in violation of the company’s “Community Guidelines” before these are sent to a creator for review. But it is not clear how accurate the ML model will be given we have seen companies like Facebookand Instagram relying on such tools for moderation and still fail.
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Snapchat says it will have “protections in place to keep minors safe and confidential in-app reporting available for both the creator of the Spotlight Snap and Snapchatters who views their Spotlight Snaps.” The feature is being opened for testing in New Zealand first and it will expand to more markets over the coming months.


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The number 350 is the limit that scientists have determined is a safe level of Carbon Dioxide, (CO2), to be in our atmosphere. Measured in parts per million, (ppm), we are above that now at 389 ppm, and rising. 350.org is making that number its mission. By raising awareness about levels of dangerous greenhouse gases in the atmosphere, 350 plans to reach that goal. CO2 levels must drop 80% by 2050 for the planet to survive as we know it. The World Business Summit on Climate Change closed Tuesday calling for the world to come together on the matter of reducing our impact. Global leaders will meet this December 7-18th in Copenhagen for COP15, (United Nations Climate Change Conference), to decide the details of the world’s climate policies.
You can take action on October 24, 2009 and join the movement at 350.org. People all around the world are uniting for the climate cause to send a loud and clear message to Politicians and businesses at COP15 that climate change policy has to be taken seriously.
- 350.org is an international campaign dedicated to building a movement to unite the world around solutions to the climate crisis–the solutions that justice demand.
- Organization Type: Non-Profit
- Website: 350.org
- Founder(s):Bill McKibben
- Founded: 2008
- Location:San Francisco, CA USA
- See complete company list here
Sources: 350.org; copenhagenclimatecouncil.com; en.cop15.dk


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News tagged with infliximab
Infliximab (INN; trade name Remicade) is a monoclonal antibody against tumour necrosis factor alpha (TNFα). It is used to treat autoimmune diseases. Remicade is marketed by Janssen Biotech, Inc. (formerly Centocor Biotech, Inc.) in the USA, Mitsubishi Tanabe Pharma in Japan, Xian Janssen in China, and Schering-Plough (now part of Merck & Co) elsewhere.
Infliximab was approved by the U.S. Food and Drug Administration (FDA) for the treatment of psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis and ulcerative colitis. Infliximab won its initial approval by the FDA for the treatment of Crohn's disease in August 1998.
Infliximab works by binding to tumour necrosis factor alpha. TNFα is a chemical messenger (cytokine) and a key part of the autoimmune reaction. Originally, it was assumed that infliximab works by blocking the action of TNFα by preventing it from binding to its receptor in the cell, and for the action of infliximab in rheumatoid arthritis. This still seems to be true. However, another TNFα-neutralizing medication, etanercept (Enbrel), is worse than a placebo in Crohn's disease and thus TNFα-neutralisation is not responsible for its powerful action in the latter disease. As infliximab causes programmed cell death of TNFα-expressing activated T lymphocytes, an important cell type mediating inflammation, but etanercept does not have this activity, now it is generally assumed that resolution of activated T cells by infliximab explains its efficacy in Crohn's disease.
Infliximab is an artificial antibody. It was originally developed in mice, as a mouse antibody. Because humans have immune reactions to mouse proteins, it was later developed into a human (humanized) antibody. Because the antibodies were produced from one cell that was grown into a clone of identical cells, it is called a monoclonal antibody. Because it is a combination of mouse and human antibody, it is called a chimeric monoclonal antibody.
Infliximab was developed by Junming Le and Jan Vilcek at New York University School of Medicine and developed by Centocor, (now Jannsen Biotech, Inc.)
Infliximab can cost $19,000 to $22,000 a year per patient wholesale, according to Centocor. Infliximab is typically covered under major medical insurance (rather than prescription drug insurance).
Other monoclonal antibodies targeting TNFα are golimumab (Simponi), adalimumab (Humira), and certolizumab pegol (Cimzia). Etanercept also binds and inhibits the action of TNFα but is not a monoclonal antibody (it is instead a fusion of TNF-receptor and an antibody constant region).
Infliximab is administered by intravenous infusion, typically at 6-8 week intervals, and at a clinic or hospital. It cannot be administered orally, because the digestive system would destroy the drug.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
Researchers at Emory University have found that a medication that inhibits inflammation may offer new hope for people with difficult-to-treat depression. The study was published Sept. 3 in the online version of Archives of ...
Psychology & Psychiatry Sep 03, 2012 | 4.9 / 5 (18) | 3 |
Biological agents used to treat rheumatoid arthritis seem to be associated with an increased risk of skin cancer, indicates a systematic review of published research in the Annals of the Rheumatic Diseases.
Cancer Sep 08, 2011 | 3 / 5 (2) | 0
Patients with inflammatory rheumatic diseases (IRD) treated with anti-tumour necrosis factor medications (anti-TNFs) have a 75% greater risk of developing herpes zoster, or shingles, than patients treated with traditional ...
Arthritis & Rheumatism Jun 07, 2012 | 5 / 5 (1) | 0

domain: medical


The Chiefs are massive, double-digit favorites over the Bears in Week 3. There’s been much said about the Chiefs’ mediocre record as huge favorites, but that narrative is overblown.
In fact, history says Chicago is terrible as double-digit underdogs and bettors should load up on Kansas City this Sunday.
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Let’s look at the odds before I explain why the value is with Kansas City.
Bears vs. Chiefs Odds, Spread and Total
Bears vs. Chiefs Prediction and Pick
Chicago lost both of its first two games by double-digits, a 38-20 drubbing by the Packers and a 27-17 loss to the Bucs.
Now, the Bears’ league-worst defense gets to face an angry Patrick Mahomes. As Travis Kelce gets healthier, I anticipate the Chiefs’ offense to improve. That’s bad news, Bears fans.
While Kansas City is just 4-8 against the spread (ATS) in its last 12 games as double-digit favorites, the Chiefs have actually covered four of their last six at home in this spot. Kansas City struggles a bit as double-digit favorites on the road, but at home, the Chiefs are a strong bet.
Recent wins for Kansas City as double-digit home favorites include a 14-point victory over Seattle, a 16-point effort against the Rams, a 36-10 domination of Pittsburgh, and a 48-9 complete beatdown of the Raiders.
The Bears, on the other hand, are a dreadful 1-6 ATS in their last seven games as double-digit underdogs, failing to cover the spread by an average of 9.58 points per contest.
Chicago is overmatched, plain and simple. The Bears have one of the worst coaching staffs in the sport and a roster marred by awful contracts and square pegs in round holes.
Don’t overthink this one. The Chiefs should win going away as the organization keeps righting the ship from the Week 1 disappointment against Detroit.


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One common objection to raising the block size limit is that it’s unclear how miners will be funded when Bitcoin’s money supply formula finally drops to zero. To quote Thomas Voegtlin of Electrum,
The discussion on block size increase has brought some attention to the
other elephant in the room: Long-term mining incentives ……. proponents of the block size increase are conservative; they are trying to preserve the current regime, which is known to work, instead of letting the network enter uncharted territory.
My problem is that this seems to lacks a vision ….. So here is my question, to both proponents and opponents of a block size increase: What steady-state regime do you envision for Bitcoin, and what is is your plan to get there?
Mining is currently funded by the creation of new bitcoins. Satoshi’s inflation formula is an astonishingly long term piece of planning — inflation halves every four years, so there is a very long time before the supply of coins dries up.
Gavin Andresen points out that attempting to guess what will happen 20 or 30 years from now is optimistic, at best. And I fully agree. I think we need bigger blocks regardless of whether you agree with this article or not.
Still, it’s nice to have at least some answer to this question, even if the best laid plans tend to get abandoned much faster than is relevant here.
So this article describes my proposed solution: hashing assurance contracts.
Satoshi’s original idea is simple: as inflation dries up, people should start attaching transaction fees to make up the difference.
Unfortunately there’s a compelling argument that this might not work. The block chain is what economists call a public good. From Wikipedia,
A public good is a good that is both non-excludable and non-rivalrous in that individuals cannot be effectively excluded from use, and where use by one individual does not reduce availability to others.
Put in plain English, the block chain is like a lighthouse. It costs money to build and keep the lighthouse operational, but once built there’s no way to stop ships from seeing the light. Thus there is a question of who pays for it. You cannot charge sailors because there’s no way to create a bright light that is invisible to freeloaders.
It may at first seem that the block chain isn’t like a lighthouse, because miners can refuse to mine a transaction that doesn’t have a high enough fee. But it doesn’t work like that: even if one miner refuses to accept a transaction into the chain, they must still process it if it is included by another.
So miners face the following conundrum. The cost of hashing is unconnected from how many transactions are in a block, so taking a transaction and collecting its fees costs you nearly nothing. You see a transaction that has a fee a bit lower than you’d ideally like, but still not zero. You could keep it around but not put it in a block, as a signal to the market that you want higher fees. But then you’re leaving money on the table. When another miner decides he’s OK with the lower price, you will have to process the transaction anyway, therefore, you might as well just take it.
This leads people to observe that they can attach a lower fee than they were doing, and transactions still work pretty much OK. Sure, they might take a bit longer to confirm, but there are really only two speeds that matter in payments: instant and not instant. If your transaction becomes a little bit more “not instant” and takes 40 minutes instead of 10, in practice that won’t affect the setup of most business payments much. So fee prices might enter some kind of downward spiral. And as mining becomes less profitable, miners will shut down hardware in order to regain their previous margins. Hash rate will fall. Wash, rinse, repeat.
Downward spiral. Really?
Well ……. maybe. Nobody knows. The argument above relies on the idea that people won’t pay to get faster confirmations, and miners won’t be able to resist including transactions no matter how little fee they attach.
This seems plausible, in that it could happen, but we don’t know it will work out that way. It may be that actually many people do care about the difference between waiting 1 block or 10, and that miners happily set a high fee threshold and stick to it (effectively constraining supply).
This article is about what happens if the downward spiral situation does play out.
How much is too much?
One key problem here is there’s no amount of hashing that’s obviously just right. Is there too much mining going on today? Or too little? How would we even know?
The simplest answer is to measure double spending fraud. If double spending due to malicious miners forking the chain is too high then valuable people will drop out of the Bitcoin economy. In that case we can say there must be too little hashing. Of course, we hit the problem of what “valuable people” means, but let’s shelve that for now.
Currently we’re not seeing malicious miners double spending by forking the chain. So there’s too much effort going into mining. That matches our intuition — it’s hard not to see mining farms like in the picture above and wonder if the tiny Bitcoin economy really justifies it. We didn’t see double spending when mining was at half the current level, or a quarter, or even before that. Currently the Bitcoin community is being effectively taxed about $832,000 per day …. just to support mining! If this was being paid with transaction fees each Bitcoin payment would cost about $7.50, which is uncompetitive.
We’re not spending so much on mining because we really need it. It’s because printing money distorts behaviour. If you connect money printing to bank lending then you get too many mortgages and then a housing bubble. If you connect it to arbitrary mathematical puzzles, you get too much effort put into solving them.
If Bitcoin were a centrally planned economy we’d probably tamper with the inflation formula at this point to try and reduce the waste. But that’d just bias the system more heavily towards early adopters. Every choice has a cost — so may as well stick with the devil we know, safe in the knowledge that Satoshi made inflation a temporary problem.
But eventually the ball-and-chain of the inflation formula will disappear, and the choice of how much mining we need will be up to us. Then what?
Who cares about blocks, really?
A slippery aspect of the Bitcoin protocol is that whilst it’s the receiver of a transaction that cares about double spending risk, it’s the sender who pays the fee.
Different transactions carry different levels of fraud risk. So different participants want different amounts of mining. In that spectrum there should be some kind of level that’s acceptable to the largest number of people, but how to discover what that is?
A simple algorithm is as follows:
- Do some trading.
- If you experience no double spending, lower the amount of money you’re contributing towards hashing.
- Once you start to see significant losses due to double spending, raise it again until the losses are acceptable.
That is probably a bit too simple — it may be better to lose some stuff to fraud than pay more towards mining. But you get the idea.
The sticking point is the “money you’re contributing” bit. Contributing how, exactly? If you don’t contribute your transactions will still clear, so why would you do that? If you do, your competitors will ride for free.
In a nutshell, this is the problem of funding public goods.
An assurance contract, more often called a crowdfund, is supposed to be a solution to the problem of funding public goods. Recall the lighthouse. We solve it like this:
- Someone with good reputation decides that a lighthouse would be useful, and becomes an entrepreneur.
- He/she calculates the cost of building it and asks every passing ship to pledge to the project. The pledge is only claimed if and when enough money is raised.
- The size of the pledge is chosen by the pledgor, based on how much they want it and how much they think other people might contribute.
If most sailors don’t really care in the end, the project won’t get funded. If they care but think they can get away with letting their competitors fund it, the project may well end up not funded at all. Eventually some of them will break the deadlock.
This is of course the Kickstarter model. And there’s already a way to do it on the block chain using Bitcoin protocol features, using an app I wrote called (guess what?) Lighthouse.
Can we apply similar technology to the problem of funding mining? I think the answer might be yes. Here’s how it’d work.
HACs (hashing assurance contracts)
We start by creating a new, independent peer to peer network. This network links people with an interest in seeing mining happen i.e. merchants, exchanges etc. Anyone can use the network to throw out a contract for N BTC and solicit pledges for it. Once the bitcoins are gathered, they are allocated to miners via pure-fee paying transactions.
Take a merchant that’s in the business of moving gold. They need a lot of mining to be viable: let’s say 1 petahash. They know from experience that with anything less than that, there’s some malicious miner out there that will fork the chain in order to double spend against them. They know that it costs at least 1 BTC per block to incentivise that much mining. So, they go onto the new p2p network and look for a contract for that much. If one exists (or is close enough), they join it by pledging. If none exists, they create one.
The technical details aren’t exciting so I’ll gloss over them here, but suffice it to say the Bitcoin protocol (with some small extensions) can be used to do all this in a trust-free manner. You don’t have to know who you are co-operating with to fund the mining. You’d just run a simple app that prints an address in a local wallet. You’d specify how much mining you need, and how much you’re willing to contribute, and then fill up the apps wallet. It would go off and autonomously spend your money to try to make that happen. When it ran out, it’d send you an email so you could fill it back up again. Contributing to mining would become a cost of business. If enough people did it, the cost could be fairly low.
There might be multiple contracts outstanding simultaneously.
Say our gold merchant needs at least 1 BTC’s worth of mining. But another needs less, they only need 0.5 BTC’s worth. The second merchant doesn’t care which contract completes: either will do. Luckily, the assurance contract protocol allows the second merchant to double pledge the same money: he can take part in any contract higher than his required amount, and whichever contract completes automatically invalidates the pledge to all the others.
A sufficiently smart mining agent might use all sorts of market theories to try and get people the best deal. Out of all the individual agents interacting in a p2p free market soup, some kind of consensus on the “right” amount of mining should appear, based on how much people are willing to pay. Transaction fees are still used, but only a few transactions will carry huge fees. The rest may contain fees close to zero, or no fee at all. Miners would include them anyway either to claim the free fee money and/or because the circulation of those coins is needed for merchants to be able to build the assurance contracts in the first place.
People want mining and they want to work together to get it. I think a decentralised P2P assurance contract system would be a neat way to solve this in the distant future, but in case it doesn’t work for some reason other ways would be found.

domain: finance


text:
Most people who abuse addictive prescription painkillers get them for free from friends or relatives, while drug dealers are a relatively uncommon source for those at highest risk for deadly overdoses, a government study found.
People who abuse them most frequently doctor-shop; more than 1 in 4 who used these drugs almost daily said they had been prescribed by one or more physicians. Almost as many said they got them for free from friends or relatives; only 15 percent of the most frequent abusers said they bought the drugs from dealers or other strangers.
Those abusers "are probably using at much greater volumes, and simply asking a friend for a pill now and then is not going to be sufficient," said Dr. Leonard Paulozzi, a researcher at the federal Centers for Disease Control and Prevention.
According to the study, two-thirds of abusers said they used the drugs infrequently, and half of those users said they got them for free.
Paulozzi and CDC colleagues analyzed four years of nationwide health surveys on nonmedical use of pain relievers including oxycodone and hydrocodone. These include the brand-name pills OxyContin and Vicodin, in a family of drugs called opioids -- chemically similar to opium.
The study was published online in JAMA Internal Medicine.
-- from wire reports