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Lauren Braddy, 21, senior, fashion retailing major was killed March 28, 2004 in a car accident on the outskirts of Orlando, Fla., after she swerved to miss some road debris. She was on her way to Fort Lauderdale to meet up with her sorority sisters for a spring break cruise to the Bahamas.
Christin Lancaster, 21, senior, early childhood education major was also killed March 28, 2004 on her way to Fort Lauderdale with Braddy to celebrate their last spring break vacation before graduating in May. She wasn't wearing her seatbelt.
Jennifer Millican, junior, was killed March 27, 2004 after her car veered off the road and struck a tree in Winston County. She was wearing her seatbelt.
Three UA students lost their lives during the spring break holiday last year. And University officials hope and pray students return safely to the Capstone this year.
"We do our best to keep everybody safe," said Chenetra Bradley, Health Promotion Coordinator at the Russell Student Health Center.
Monday marked the beginning of Safe Spring Break Week at the University. The Russell Student Health Center, the Counseling Center and the Healthy Campus Initiative are awaiting the arrival of safe spring break kits to distribute to students before the holiday begins March 25.
Tips on international and domestic travel, bandages, condoms, sunscreen and lip balm are a few of the items included in the kit.
Automobile and highway safety is just one of many factors students should consider when planning their spring break vacation. Whether it is a trip to the beach, flying overseas, staying in Tuscaloosa or returning home to visit family, the University is pushing the theme of safety.
"When you're talking about students and spring break travel, there's a lot to think about," Bradley said. "Sun safety, alcohol responsibility, sexual responsibility, personal safety -- they're all important. I don't want to leave anything out."
The Women's Resource Center is advising college females to be extra careful this spring break. The center has distributed colorful cards addressing the subject of drug-facilitated rape.
"Spring break is a time for having fun. However, we need to make sure that we are not so carefree that we forget about our own safety," the card reads.
More than ever, national organizations want to raise awareness about the possible dangers spring breakers face.
The Bacchus and Gamma Peer Education Network released its safe spring break guide for 2005 entitled "Get a Clue." College students across the country are asked to sign an online pledge, vowing to engage in healthy spring break activities. Those who sign the pledge are entered into a contest to win a lease for a Chrysler car.
A copy of the "Get a Clue" guide can be found at the Russell Student Health Center, and Bradley regards it as a fine resource for UA students. The guide includes a road safety tip sheet, blood alcohol impairment charts as well as facts about HIV transmission. Bacchus and Gamma's goal is to prompt college campuses to carry out educational programs about spring break safety.
Bradley understands students want to let loose and have fun during spring break, but said students should find a balance between having a good time and displaying good judgment.
"Students sometimes think they have to be wild and crazy to have fun and that's a misconception," she said. "It's peer pressure a lot of the time. Usually what students do to have fun doesn't involve doing crazy things."
Cassandra Mickens can be contacted at firstname.lastname@example.org.


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Changes in HDL cholesterol, particles, and function associate with pediatric COVID-19 severity
Frontiers in cardiovascular medicine
HDL function; HDL subspecies; HDL-cholesterol; NMR lipoprotein analysis; lipoprotein Z; pediatric COVID-19 severity
Background: Myriad roles for high-density lipoprotein (HDL) beyond atheroprotection include immunologic functions implicated in the severity of coronavirus disease-2019 (COVID-19) in adults. We explored whether there is an association between HDL and COVID-19 severity in youth. Methods: A pediatric cohort ( = 102), who tested positive for COVID-19 across a range of disease manifestations from mild or no symptoms, to acute severe symptoms, to the multisystem inflammatory syndrome of children (MIS-C) was identified. Clinical data were collected from the medical record and reserve plasma aliquots were assessed for lipoproteins by NMR spectroscopy and assayed for HDL functional cholesterol efflux capacity (CEC). Findings were compared by COVID-19 status and symptom severity. Lipoprotein, NMR spectroscopy and CEC data were compared with 30 outpatient COVID negative children. Results: Decreasing HDL cholesterol (HDL-c), apolipoprotein AI (ApoA-I), total, large and small HDL particles and HDL CEC showed a strong and direct linear dose-response relationship with increasing severity of COVID-19 symptoms. Youth with mild or no symptoms closely resembled the uninfected. An atypical lipoprotein that arises in the presence of severe hepatic inflammation, lipoprotein Z (LP-Z), was absent in COVID-19 negative controls but identified more often in youth with the most severe infections and the lowest HDL parameters. The relationship between HDL CEC and symptom severity and ApoA-I remained significant in a multiply adjusted model that also incorporated age, race/ethnicity, the presence of LP-Z and of GlycA, a composite biomarker reflecting multiple acute phase proteins. Conclusion: HDL parameters, especially HDL function, may help identify youth at risk of more severe consequences of COVID-19 and other novel infectious pathogens.
Mietus-Snyder, Michele; Suslovic, William; Delaney, Meghan; Playford, Martin P.; Ballout, Rami A.; Barber, John R.; Otvos, James D.; DeBiasi, Roberta L.; Mehta, Nehal N.; and Remaley, Alan T., "Changes in HDL cholesterol, particles, and function associate with pediatric COVID-19 severity" (2022). GW Authored Works. Paper 1779.

domain: medical


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Talking to our kids about dating and sex can be awkward. Just as we teach our children about proper manners and study skills, we need to coach them about sexuality and romantic relationships, she says. To help them navigate this exhilarating, blissful, painful, and confounding aspect of life, you have to get over those feelings of embarrassment and get ready for some honest conversations. In order to give our kids advice, we need to educate ourselves on the ages and stages of dating, says Andrew Smiler, Ph. Dating tends to happen in three waves, he explains. In the fifth grade, many experience their first real crushes and couples begin to form — though they tend not to interact after school. By the second phase, usually in middle school, kids begin to socialize on their own time, primarily via devices.
Secrets to Lasting Relationships From High School Sweethearts
Accidentally stepping on the back of his shoe, interrupting her during a class presentation, being set up in a parking lot at a youth group event. Adolescence is steeped in awkwardness and hormones. But there are couples who meet during that time of change and confusion who find — and stay in — love. The perception that a high school romance is likely to end when college or adulthood begins is not lost on these couples.
We asked a few of them how they met the challenges of growing up while being in a relationship. They revealed their secrets and explained how their partnerships thrive today.
Circle of Moms member Lynn W. I’d say maybe 9th grade might be okay, but am not really sure. Many moms say that the dating issue is likely to come up for the first time during the tween years, and that it can make a parent surprisingly anxious. But moms who’ve already been through this stage say it needn’t be cause for stress; the key is to figure out whether your particular child is truly ready to begin dating.
Nichole N. She suggests parents sit down with their pre-teens to discuss the issue calmly, before it even comes up. This conversation will help you figure out if your child is ready.
What’s the Right Age for Teens to Start Dating? The Great Debate
Visit cdc. Healthy relationships in adolescence can help shape a young person’s identity 1 and prepare teens for more positive relationships during adulthood. Frequency of adolescent dating. Young people tend to become more interested in dating around their mid-teens and become more involved in dating relationships during high school.
What Vaccines Do Adolescents Need? Providing adolescents with tools to start and maintain healthy relationships (with Nearly two-thirds of teens (ages ) have not been in a dating or romantic relationship. This change is most striking for 12th-grade students, where the percentage of youth who did not date.
I met a few guys who I liked when I went away. At first, everything was going great. I finally felt like I had met someone who actually understood me and cared for me. He always walked me home after a date to make sure I got home safe. We could talk about anything, and it felt like we understood each other completely. It was magic. Unfortunately, all that changed a few weeks later.
Age gap: Things to know about dating someone older
But when the age difference is bigger, there are other things to consider. An age difference of a few years may not seem like an issue, but things such as expectations, priorities and general interests can change quickly as you get older. Healthy relationships vs.
s Of New European Women Sign Up Every Week. Don’t Wait. Join Now & Start Meeting Them!
My year-old daughter is maturing very fast. She’s told me that she likes guys at school, but I’m not sure if I should let her date. Although your daughter may look years older than her age, her emotional intelligence, reasoning, and judgment have a long way to go to catch up to her body. In essence, she may be a girl with the body of an older teen, but her emotional and intellectual makeup remains that of an year-old.
Older boys often pursue girls who mature earlier physically and these girls are often flattered and excited by this attention for example, the freshman girl who is romanced by the senior boy. Carleton Kendrick has been in private practice as a family therapist and has worked as a consultant for more than 20 years. He has conducted parenting seminars on topics ranging from how to discipline toddlers to how to stay connected with teenagers.
Advice given here is not intended to provide a basis for action in particular circumstances without consideration by a competent professional. Our expert believes that year-olds are far too young to engage in dating behaviors. Many girls in your daughter’s generation are maturing physically at a more rapid pace than those in previous generations.
The Dos and Don’ts of Being in a Relationship in College
When they met: In sixth grade but started dating in 10th grade. When they married: Aug. 30, , at 21 and Do you still show affection for.
From finding the time to which single parenting dating apps to try first, get seven smart tips from our single parent dating pros. Getting back into the dating game as a single parent can seem daunting. Where do you look? How do you find the time to go out? How much should you tell your kids — or the cutie across the table?
Our relationship experts help you navigate the single-parent dating scene. Whether you’re six months post-divorce or six years, there is no “right” time to start dating. What are you looking to find? What needs are you looking to fill? Sometimes, Baumgartner says, the voids in your life may be better filled in ways other than dating. If you’re dying to get out of the house, call your girlfriends for a night out. If you want to feel wanted, volunteer.
If you’re looking to get your heart pounding, try some cardio.
The New Rules for Teen Dating
Dating calculates the date abstract: accurate. Daters are those in their 50s and other dating age grade calculator; baseball on-base percentage; american football position calculator determines the date person. Report shows the past three years between two midpoint dates than women in the younger than my area! Is a date calculators can deal with more.
I don’t know if you knew, but it goes down in fifth grade, from the DMs to school hallways. System that “African-American and Hispanic girls tend to start puberty slightly Syreeta: Do you ever find yourself wanting to date?
This article was updated April 26, , but was originally published Feb. Read an updated feature story with information on how social media is affecting teen dating here. Perhaps the thought of all those sweet young couples slow dancing under paper streamers coaxes a nostalgic sigh or two. Ah, reality. What to watch for: Smartphones and social media can lay traps for preteens and young teens.
Young teens have especially fragile egos, so negative peer feedback on social media can be especially damaging. The rest are either completely single or talking to someone. Parents should try to stay on top of who their child is talking to or dating, and why — especially with younger teens. This is a prime opportunity to find out what they find appropriate and desirable in a romantic partner, says Crystal Reardon, director of counseling for Wake County Public School System.
The group eats dinner together, poses for pictures together and attends the dance together. Of course, kids who already have relationships — and even some still in the talking phase — will go with that special person, but still as part of a group. To college students, hooking up means having casual sex.

domain: sociology


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Build a solid foundation in science, formulation and product development—find out more!
Most Popular in:
FDA Proposes New Sunscreen Rules
Posted: August 24, 2007
The US Food and Drug Administration (FDA) has proposed a new regulation that sets standards for the formulating, testing and labeling of over-the-counter (OTC) sunscreen drug products with ultraviolet A (UVA) and ultraviolet B (UVB) protection.
"For more than 30 years, consumers have been able to identify the level of UVB protection provided by sunscreens using only sunburn protection factor or SPF values," said Andrew C. von Eschenbach, MD, Commissioner of Food and Drugs, in the FDA press announcement. "Under [this] proposal, consumers will also now know the level of UVA protection in sunscreens, which will help them make informed decisions about protecting themselves and their children against the harmful effects of the sun."
Sunlight is composed of visible light and ultraviolet (UV) light. The two types of UV light of primary concern are UVA and UVB. UVA is responsible for tanning and UVB, for sunburn. Both can damage the skin and increase the risk of skin cancer. According to the FDA the proposed regulation creates a consumer-friendly rating system for UVA products that is designed to help consumers identify the level of UVA protection offered by a product. The ratings system is on a scale of one to four stars. One star would represent low UVA protection, two stars would represent medium protection, three stars would represent high protection, and four stars would represent the highest UVA protection available in an OTC sunscreen product.
If a sunscreen product does not provide at least a low level (one star) of protection, the FDA is proposing to require that the product bear a "no UVA protection" marking on the front label near the SPF value. Ratings would be derived from two tests the FDA proposes to assess the effectiveness of sunscreens in providing protection against UVA light. The first test measures a product's ability to reduce the amount of UVA radiation that passes through it. The second test measures a product's ability to prevent tanning. This test is nearly identical to the SPF test used to determine the effectiveness of UVB sunscreen products.
In addition, a "Warnings" statement in the "Drug Facts" box will be required of all sunscreen product manufacturers. The warning will say: "UV exposure from the sun increases the risk of skin cancer, premature skin aging, and other skin damage. It is important to decrease UV exposure by limiting time in the sun, wearing protective clothing, and using a sunscreen." The warning is intended to increase awareness that sunscreens are only one part of a sun protection program.


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Department of Environmental Conservation
Financial Statements for the Title V Operating Permit Program for the Two Years Ended March 31, 2005 In the Title V Operating Permit Program, the Department of Environmental Conservation regulates the amount of pollutants emitted by large businesses. The Program is financed by an annual fee assessed on the regulated businesses and, to the extent that Program costs are not covered by fee revenue, by State appropriations. As of March 31, 2005, the Programís fund balance totaled $1.7 million. We audited the consolidated statements of revenues, expenses and changes in fund balances pertaining to the Program for the two years ended March 31, 2005. We concluded that the financial statements were presented fairly in all material respects.
For a complete copy of Report 2005-S-74 click here.

domain: economics


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BROOKSVILLE — An Eastside Elementary School teacher has filed a gender discrimination complaint with the U.S. Equal Employment Opportunity Commission.
Heather McCarty, a 44-year-old third-grade teacher at the school east of Brooksville, filed the complaint recently, district officials confirmed this week. They declined to provide more details, citing advice from legal counsel.
Pending complaints are not public record, and EEOC officials do not release or comment on them, so the circumstances of McCarty's grievance are unclear. She did not return a phone message left by the Times.
Employees can file a complaint if they suspect they have been discriminated against because of race, color, religion, gender, national origin, disability or age. Complaints are often addressed in mediation. If not, or if mediation fails, an EEOC investigator will take the case, according to the commission's website.
If an investigation finds a violation, the commission seeks a voluntary settlement with the employer. If that fails, the case goes to the commission's legal staff to decide whether the agency should file a lawsuit. The employee can sue if the commission opts not to.
Heather Martin, executive director of business services, declined to say how far along McCarty's complaint is in the process.
McCarty is a member of the local teachers union, but did not seek help for the matter, said Joe Vitalo president of the Hernando Classroom Teachers Association.
Beverly Chapin, the school's principal, is McCarty's direct supervisor and currently the sole administrator at the school. Chapin decided to cut the assistant principal position during last year's round of budget cuts.
McCarty joined the district in 2002, working as a teacher at J.D. Floyd Elementary for a year before heading to Eastside. She spent six years there, worked for a year at Explorer K-8, then returned to Eastside at the start of the 2010-11 school year.
She has had at least two perfect annual evaluations in recent years, including one by Chapin for the 2008-09 school year. Her disciplinary record is free of blemishes.
Tony Marrero can be reached at (352) 848-1431 or [email protected]

domain: news


EvoFish in Bekkjarvik
Following the tradition establish in 2015, EvoFish convened at the Bekkjarvik Gjestgiveri for the annual meeting.
During May 9-10, we EvoFishers convened for our annual meeting at the historic Bekkjarvik Gjestgiveri. The programme was based on presentations and discussions, combined with good food and company. We saw updates from five master's projects, two PhD projects, environmental disaster in Vietnam, and many more. And not the least, we were spoiled by the most wonderful spring weather that our northern latitudes can offer!


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“I know what society stereotypes say about dads.
Moms do all the hard stuff.
Dads have all the fun.
Moms are the ones who are burned out.
Dads have it easy.
I’ve seen all the memes and videos.
I’ve read all the articles.
I’ve heard all the jokes.
Heck, I’ve even written a few myself.
And I guess for some, those stereotypes might be true. Which is perfectly fine.
Every family is different.
But sometimes they aren’t.
Sometimes those stereotypes get it wrong.
Sometimes dads drive carpools and pack lunches.
Sometimes dads rock babies to sleep and wake up for 3 a.m. feedings.
Sometimes dads tie ponytails and sing Disney songs at the top of their lungs.
Sometimes dads build Lego and fix boo boos.
Sometimes dads rub in sunscreen and remember to reapply a few hours later.
Sometimes dads know the schedules.
Sometimes dads make dinner, and even breakfast too.
Sometimes dads give the baths and cup their hand against tiny foreheads so the soap doesn’t get in their eyes.
Sometimes dads fill out reading logs.
Sometimes dads pack the backpacks.
Sometimes dads know the trick to get those sleepy eyes to close and the cries to settle.
Sometimes dads give moms a break without asking.
And sometimes dads need a break too.
Because they do the hard stuff.
They get burned out.
They love unconditionally.
And they deserve way more recognition than society gives them.
Here’s to all the working dads, the stay-at-home dads, the step-dads, the granddads, the single dads, the foster dads, the dads in heaven, and the dads who desperately want to be dads but maybe haven’t gotten there quite yet.
We celebrate you.”
Read more from Mari here:
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PRICE REDUCED. 1941 M38 Husqvarna in good condition. Barrel has some wear but plenty of life left. Stock has been refinished and in good condition no marks or dints. Has had a stock repair at some stage in its life. Very nice straight shooting rifle. Reluctant sale.


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High-throughput Screening platform
Single B Cell Screening Platform
9MW0113 is a recombinant humanized anti-TNF-α monoclonal antibody injection jointly developed by Mabwell and Junshi Biosciences. The mechanism is that the antibody binds to TNF-α and reduces the TNF-α-activated immune response, thereby inhibiting the inflammatory response.
9MW1911 is an innovative humanized monoclonal antibody drug independently developed by Mabwell, a domestic pharmaceutical company in China. The drug’s antibody molecule is derived based on the B-lymphocyte screening platform, and the product is characterized by higher binding affinity and potent biological activity. Nonclinical studies have shown that the in vivo mechanism of action of this product in animals was definite and clear. After binding specifically to the target ST2, it blocks the activation of ST2-mediated signaling pathway induced by cytokine IL-33, hence inhibiting the inflammatory reactions and achieving therapeutic effects in multiple auto-immune diseases.
9MW0321 is a recombinant human anti RANKL monoclonal antibody injection. It can inhibit the activation of OPG/RANKL/RANK signal transduction pathway by binding with RANKL, so as to inhibit tumor growth and reduce bone damage.
8MW0511 is recombinant (Yeast-secreted) Human Serum Albumin-human Granulocyte Colony-stimulating Factor Fusion Protein for Injection. Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is engineered by human serum albumin fusion technology to increase the half-life of rhG-CSF in human and prolong the dosing cycle, and to slow release of rhG-CSF and continue to promote the development and release of neutrophils, thereby reducing the incidence, duration, and severity of chemotherapy-associated neutropenia.
6MW3211, developed based on Mabwell's Bispecific Platform, is designed to selectively bind to CD47 and PD-L1 on tumor cells to attenuate CD47-SIRPα signal and block the PD-1/PD-L1 checkpoint inhibition, thereby triggering stronger tumor cell phagocytosis and enhancing T cell activation. The IgG-like structure with a common light chain is the strategy to overcome pairing problem and simplify the production process.
9MW1111 is an innovative recombinant humanized anti-PD-1 monoclonal antibody targeting PD-1 independently developed by Mabwell. By binding to PD-1 on the surface of T cells, 9MW1111 blocks the binding of PD-1 to the ligands PD-L1 and PD-L2, thus eliminating the immunosuppression of PD-1 signal transduction pathway and restoring the immune function of T cells to attack tumor cells.
9MW2821 is a novel anti-Nectin-4 ADC drug candidate developed by ADC platform and automated high-throughput antibody discovery platform of Mabwell. It boasts the advantages of homogenous structure, high purity and being easy production. It has also demonstrated favorable druggability properties in binding affinity, endocytosis, preliminary in vivo and in vitro pharmacodynamic activities, drug metabolism properties and preliminary safety.
8MW2311 for injection is a polyethylene glycol coupled human interleukin-2 immunoagonist for the treatment of advanced malignant tumors. After 8MW2311 is injected into the body, it can stimulate the phosphorylation of downstream transcription factor STAT5 and effectively stimulate the proliferation of killer T lymphocyte CD8+T cells, so as to exert its efficacy.
6MW3511 is a bifunctional group drug protein independently constructed by Mabwell using humanized anti-PD-L1 nanobodies to link to TGF-β RII mutants. The mutant design facilitates the maintenance of whole-molecule stability and reduces degradation of the natural TGF-β group during the manufacture process and in vivo. By blocking PD-1/PD-L1 and TGF-β/TGF-β-R dual pathways simultaneously, and with the excellent local tumor penetrability resulting from the concise structure, 6MW3511 is expected to further address the difficult problem of immunosuppression in the tumor microenvironment. The results of preclinical studies showed that 6MW3511 injection had good in vivo anti-tumor efficacy and good tolerability in animals. It is intended to be used clinically for the treatment of a variety of advanced solid tumors.
9MW0311 is an independently developed recombinant fully humanized anti-RANKL monoclonal antibody injection. The mechanism of action is that after the combination of RANKL, it can prevent the activation of RANK, inhibit the formation, activation and survival of osteoclasts, and reduce bone resorption, so as to eliminate the symptoms of systemic osteoporosis or local osteolysis.
9MW0813 is an independently developed recombinant human VEGF receptor-antibody fusion protein. 9MW0813 is a fusion protein formed by recombining the extracellular region binding domains of VEGFR-1 and VEGFR-2 with the Fc segment of human immunoglobulin, which can bind to VEGF-A and PlGF, and has wide applications scope. It is expected to be complementary in the treatment of ocular diseases related to neovascularization.
9MW0211 is a recombinant anti-VEGF humanized monoclonal antibody obtained based on rabbit monoclonal antibody and humanization modification technology. It can specifically bind to VEGF-A, the most active protein in VEGF family, and block its binding to receptors on the surface of endothelial cells, reducing vascular permeability and blocking the generation and development of neovascularization, and reducing leakage caused by neovascularization, thus achieving the treatment of neovascularization-related eye diseases such as neovascular (wet) age-related macular degeneration.
9MW3311 is an innovative monoclonal antibody with a neutralizing effect on COVID-19. 9MW3311 works by binding with high affinity to the S1RBD region of the S protein, blocking the S1RBD from binding to ACE2 and thus preventing the virus from entering the host cell, thus achieving a neutralizing effect on the virus and a protective effect on the host cell.
9MW1411 is developed based on the technology of automated high-throughput hybridoma antibody molecule discovery platform. The mechanism of action of 9MW1411 is that the drug binds to α-toxin protein monomer, thus blocking the binding of α-toxin monomer to the receptor ADAM10 on the surface of cell membrane, inhibiting the toxicity of α-toxin to human cells, protecting the barrier of epithelial tissue from damage, and alleviating inflammatory reactions, therefore reducing the detrimental effect of Staphylococcus aureus infection to patients.
Mabwell has built an automatic high-throughput hybridoma antibody new molecular discovery platform, which is equipped with international advanced equipment, has an independently integrated workstation system, and is combined with a variety of animal immune technologies, efficient and stable hybridoma electrofusion technology, serum-free hybridoma suspension culture technology, real-world flow screening technology and many other underlying technologies. Meanwhile, in the antibody engineering transformation optimization system composed of computer-aided design and various display technologies, the platform adds physical and chemical stability indicators such as antibody expression characteristics, molecular binding epitope and hydrophobicity to ensure that the obtained innovative molecules meet the needs of industrialization. In addition, the platform also has a unique affinity mature transformation technology. On the basis of maintaining the activity of antibody molecules, it can greatly improve the binding affinity of antibody molecules, effectively improving the probability of druggability of innovative molecules.Advantages：
1) The target development scope is wider and the immune success rate is improved from the source.
2) Highly efficient, stable and reproducible hybridoma electrofusion technique, increasing the hybridoma screening abundance, and being conducive to obtaining candidate antibody molecules.
3) Workflow integrating manipulator and high-throughput antibody sorting equipment.
4) Serum free hybridoma suspension culture significantly accelerated the cloning and screening and reduce the incidence of false positive.
5) Antibody multi property evaluation system for cell stereoepitope level.
Mabwell’s high efficiency B lymphocyte screening platform is based on the direct separation of antigen-specific B lymphocytes from the spleen of immunized animals and human peripheral blood, and the antigen-specific B lymphocytes were enriched and the primary B lymphocytes were cloned and expanded by using the proprietary technology of efficient panning and clonal amplification. The use of efficient panning technology has achieved the screening of one hundred thousand B lymphocytes that can specifically bind to antigen from one hundred million B lymphocytes, the positive rate of secreted antibody binding to antigen is more than 90%, which significantly improves the discovery rate of high affinity antibody molecules, reduces the loss of positive B lymphocytes and improves the abundance of candidate antibodies in the process of panning. The high affinity antibody gene that is difficult to obtain by conventional cell fusion can be obtained by using the high-efficiency B lymphocyte screening technology, thus, better candidate antibody molecules are obtained, which enriches the technical means of new antibody molecule discovery.Advantages：
1) The positive rate of antigen-specific B lymphocytes was significantly increased.
2) Naturally stable antibody sequences can be obtained by screening.
3) The antibody molecular screening process has high fidelity, and the operating samples can be frozen for a long time.
4) Antibody molecular screening has strong pertinence and low research cost.
5) The technique is highly versatile and can achieve cross-species adaptation.
Mabwell’s ADC Platform is established based on two third-generation antibody coupled drug technologies, namely bridged fixed-point coupling technology and dispersed fixed-point coupling technology. Two different coupling technologies have submitted patent applications for connexon. The coupling process is reliable and the coupling product is more uniform and better than the ADC developed by other bridging fixed-point technologies. Compared with other types of antibody-drug conjugates, it has better pharmacokinetics, pharmacological and toxicological characteristics.Advantages：
1) Two different coupling technologies can develop ADC drugs for different types of high activity small molecule drugs.
2) The two different coupling techniques are applicable to the common antibody IgG1, and the natural antibody sequence can be used directly.
3) The conjugates have excellent uniformity, simplified process, easy quality control, and can significantly expand the therapeutic window in the process of use.
Mabwell's Bispecific Platform has three mature design schemes of Fc fusion protein like double antibodies in the form of common light chain, heterodimer structure and head tail structure, which can be optimized according to the characteristics of different double antibodies/proteins, The key common problems of engineering cell line screening, production process and quality control were solved, which laid a foundation for the comprehensive expansion of double antibody technology.Advantages：
1) Differential design based on the molecular characteristics and functional requirements of the antibody reduces the difficulty of process development and quality control in the development stage and even the commercial production stage.
2) Take design as the source to solve the difficulties in process development, improve the stability of antibody molecules, improve the expression in the culture process.
3) Significantly reduce the production cost of bispecific/bifunctional antibodies, make the products more clinically accessible after commercialization.
This technology platform adopts the latest reversible release modification technology in vivo to couple PEG with recombinant protein drugs through degradable connexon to obtain protein drugs with new structure and physicochemical properties. This modification technology is developed based on the first generation technology of random multi-point modification and the second generation technology of fixed-point modification, forming a unique production process and quality control proprietary technology, which has been verified by product development.Advantages：
1) Inactive prodrug design to reduce toxicity.
2) Conditionally dependent release increases efficacy
3) Prolonged dosing interval and increased compliance
4) Strict quality control to meet the most stringent commercial needs


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I’ve loved Melbourne for a very long time. I used to work there, my hubby comes from there and some of the bestest friends you could ever have live down there.
After a sensational 5 days at the Stitches and Craft Show, I now love Melbourne even more! I got back last night and am still so exhausted that I can barely type but I also can’t wipe the smile off my face. The other indie crafters there were hilarious, lovely and very inspirational.
Jodie from Ric Rac had me literally in stitches (and spent a good deal of time laughing at me … yes at, not with me 🙂 How gorgeous is this elephant of hers?
I had to stop myself from buying everything on Lisa from The Red Thread’s stand, her illustration is just gorgeous.
and Kristen Doran’s work just beamed at me from across the way each day.
Meeting lots of you lovely people who read this little blog of mine was fantastic. I spent way too much money on fabric and supplies and now have about a million different sewing projects in my head.
A big, big thank you have to go out to Kate (One Flew Over) manned the stand while I did softie classes and the gorgeous Bea who helped me out all weekend. I couldn’t have done it without you!
A full loot report (oh yes, there is a ridiculous amount of loot to show you) to come in the next couple of days. I really do love Melbourne.

domain: artistic


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While training as a pulmonary fellow at the University of Pennsylvania, I became fascinated by patients who suffered from sleep-related breathing disorders. Many of these patients stop breathing hundreds of times every night.
I decided that the evaluation and treatment of patients with the obstructive sleep apnea syndrome would ultimately play an important part of my career as a pulmonary and critical care medicine physician.In 1987, I became an attending physician at Pennsylvania Hospital. As I began to lecture other physicians about the obstructive sleep apnea syndrome, many referrals followed. In 1991, along with Dr. Charles Cantor, I started a one-bed sleep center. This center quickly grew to a four-bed program performing 1,000 sleep studies per year. My fascination with sleep medicine evolved and I became interested in all aspects of sleep disorders.
This article will focus on the dangers of not getting enough sleep and how sleep deprivation can kill you.
Sleep Deprivation Can Kill You
In the late 1800s, Thomas Edison illuminated the world with the incandescent light bulb. Little did he know that his great work would someday be a major contributing factor to the development of widespread sleep deprivation. In 1900, adults in the United States slept an average of nine hours per night. In 2000, adults slept an average of just seven hours per night. We have not evolved to need less sleep, but we are getting less sleep. In past centuries, our sleep/wake cycle was closely linked to the rotation of the earth. We slept when it was dark and we awoke and worked when it was light.
However, with the development and widespread availability of artificial light, we have prolonged our waking hours. Stimulants such as caffeine have also contributed to longer periods of wakefulness.Now that we’re all getting less sleep, you should know the five ways sleep deprivation can kill you.
1. You could die in a car crash
It is estimated that 100,000 car crashes occur yearly because of drowsy driving. This contributes to 1,500 deaths and countless disabling injuries annually on our highways.
2. You could die at work
You undoubtedly are judged at work on a regular basis. Not getting enough sleep will affect your job performance and could contribute to being passed over for promotion or loss of your job. Worse yet, if your work involves operating heavy machinery or driving a motorized vehicle such as a truck, bus or forklift, you could hurt or kill yourself or someone else.
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3. You could become irritable, depressed and suicidal
Deep refreshing sleep is essential for feeling rested and well. If you are not getting enough sleep, this could make you feel very sad and could contribute to significant relationship difficulties. If this is a chronic condition, your prolonged depressed state could lead to thoughts of suicide.
4. You could gain weight
Obesity is a major problem in the United States. It contributes to premature death from problems such as heart attacks and strokes. While poor eating habits certainly contribute, lack of sleep is also likely a factor. The hormone leptin has a significant impact on appetite for food. Increased levels suppress appetite. There is evidence that not getting enough sleep lowers your leptin levels. This results in an increase in appetite and weight gain. So getting better sleep can help you lose weight.
5. You could develop diabetes mellitus
Diabetes is associated with increased levels of sugar in your blood. It is the No. 1 cause of blindness in the United States and contributes to many other life-threatening problems such as heart attacks, strokes and renal disease requiring dialysis. It can shorten your life. There is evidence that not getting enough sleep can lead to metabolic changes that cause diabetes mellitus.
Sleep is essential for our well-being. As we get older, good sleep is often harder to come by. With the aging process, we experience less of the deep sleep known as slow-wave sleep. Combine this with medical problems such as arthritis, reflux, heart and lung disease and you have a recipe for ongoing sleep problems.


BEML Privatisation Deferred, Confirms Central Government
The central government has confirmed that the move to privatise the Bharat Earth Movers Limited (BEML) has been deferred. This was stated by Subhash Bhamre, Minister of State for Defence, as the answer to the question raised by Lok Sabha member MB Rajesh on Wednesday.
"Government has deferred the strategic disinvestment of BEML in order to undertake further diligence exercise on various aspects as considered necessary," said the answer given by the Minister.
BEML was the first Defence Public Sector Unit being put up for sale to the private sector, a move which is expected to adversely affect national security and self-reliance.
26% of the shares of BEML were slated to be sold by the central government and management control was to transferred to a private strategic buyer.
The workers of BEML, a Mini-Ratna company, had waged a prolonged struggle against the disinvestment of the strategically significant company which manufactures missile launchers, armoured vehicles, Tatra trucks and other defence equipment as well as metro and rail coaches. The company's assets are estimated to be worth well above Rs. 50,000 crore.
The company has been making profits from its inception, with profits in the last ten years alone amounting to Rs. 1141.36 crore.
Kerala CM Pinarayi Vijayan had written to the central government urging the latter not to go ahead with the privatisation move, while the workers held several protests, including a two-day protest in Delhi on 9th and 10th August 2017. The protest in Delhi was joined by BEML employees from Bangalore, Mysore, Palakkad and Kolar Gold Fields.
Protesting employees have been saying that the privatisation of the Defence PSU will entail massive corruption, just as was evident in the case of several privatisation deals where PSUs were undersold by huge amounts.
Earlier reports had said that the disinvestment move has been put on hold considering the warning by the Defence Ministry that privatising the company would be detrimental to national security. The reports have been officially confirmed now.
MB Rajesh, whose constituency Palakkad has a BEML unit, had raised the issue in the Lok Sabha several times, demanding that the centre drop the privatisation plan.
"BEML employees across the country were waging a powerful struggle against privatisation. The central government has been forced to defer the privatisation move for now as a result of such resistance," Rajesh said in a Facebook post. "This experience shows that resistance both inside and outside the Parliament against the sell-out of profit-making public sector undertakings can bear fruit."
"I greet the BEML workers who embarked on the path of struggle against privatisation. We should remember that the central government will return with this move yet again, and hence we should exercise utmost vigilance to mount resistance against it," Rajesh said.
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The County Leitrim Heritage Forum was established by Leitrim County Council as a non-statutory advisory group. The remit of the group is to provide advice to the local authority on the preparation and implementation of a Heritage Plan for Leitrim.
The Heritage Forum held its first meeting in February 2019.
Heritage Officer Sarah Maloney hosted the inaugural meeting in the form of a workshop with Forum members working in groups to identify heritage priorities for the new Heritage Plan.
A public consultation process followed the meeting. Entitled ‘What’s Your Leitrim Heritage ?’ it was held over six weeks between March 27th and 10th April. A total of 124 individuals took part in the pre-plan public consultation.
In the wake of the public consultation, three Heritage Focus Groups were established.
- built heritage
- natural heritage
- cultural heritage
The role of these groups was to assist the Heritage Forum.
Feedback and results from the Forum meetings, the public consultation process and the three Heritage Focus Groups informed the Heritage Plan priorities and the Actions included in the plan.
The Draft Heritage Plan is now at an advanced stage. It will go to public consultation in January 2020.
Leitrim PPN representatives ,Patricia O’Loughlin, Sean Gill and Seán O’Suilleabhain attended meetings in February, May, June and September.
February: Issues/ concerns brought to the Heritage Forum by Leitrim PPN representatives included forestry, signage and access to sites.
The public consultation on-line survey of six weeks was also promoted.
May: The setting up of the three Focus Groups-natural, built and cultural environment discussed, as was the issue of the Heritage Plan priorities and Heritage Forum membership.
The three Focus Groups were debated with the PPN representatives asked to pick an area of interest and a working group.
June: Patricia O’Loughlin reported that at the June meeting, issues brought forward were a built heritage meeting, the natural, built and heritage groups as was access to sites and funding.
Items discussed included the areas representatives were interested in, insurance and working with farmers/ people in terms of access to sites.
September: At the September meeting, issues/ concerns brought to the Forum included
- access to sites
- the need to pinpoint areas of specific work.
Items discussed included the Heritage Plan 2020-2015, implementation of the plan, raising awareness and recording Leitrim’s heritage. Projects on which to work were also discussed as was rolling out the plan.
Actions required before the next meeting included picking the built heritage area to work in.
Other committee members raised the issues of oral heritage, cultural and natural heritage, while issues from the PPN representatives included working with heritage groups or other community groups.
It was certainly a busy year for the PPN representatives.
PPN Rep Seán O’Suilleabhain said: “Bhí sé spéisiúil bheith mar bhall den bhFóram.
Bhí seans ag gach duine a dtuairimí a nochtadh agus bhíomar go léir ar chómhintinn faoi na moltaí.
I felt being involved in the Forum gave one an opportunity to advance the prospects of support for, in my case. the Irish language and culture.
There was general unanimity in relation to the proposals, which was good.
No conflicting interests.”
If you have any questions about the work of the Heritage Forum or that you would like raised by our PPN representatives, please get in touch.
Leitrim PPN, Aras an Chontae, Carrick on Shannon, Co Leitrim N41 K2VA
Ph: 071 96 20005 ext 544/555 Mob: 087 183 1253


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The 58-year-old Lake Tomahawk woman charged last week with attempted first-degree intentional homicide, following a June 22 domestic dispute that left her boyfriend with a gunshot wound to the shoulder, changed her story during interviews with detectives conducted after her arrest, the criminal complaint filed in the case alleges.
According to a complaint filed June 24, Christine R. Stammler told police she and the alleged victim were in the midst of a "domestic altercation" that had been going on for a few hours when she loaded a .22 caliber long rifle in her bedroom and gave it to the alleged victim who placed it on the kitchen table.
She went on to state that she "re-acquired the gun in the kitchen and shot (victim) as he lunged for her," according to the complaint.
However, upon requesting a second interview with detectives, Stammler "recanted" part of her statement.
"Stammler corrected her statement by stating the initial part was true, she did indeed load the gun, give it to (the alleged victim), and re-acquired the gun in the kitchen," the complaint states. "Stammler stated (the alleged victim) did not lunge at her and she just anticipated that (he) was going to lunge at her. Stammler stated (he) was standing in the corner of the kitchen with a smile and smirk on his face and his hands open in front of his body."
She stated that she wasn't sure if she could outrun the man to the door to leave, so she aimed the rifle at his shoulder and shot him, the complaint alleges.
According to the complaint, Stammler made no attempt to leave over the course of the three to four hours the argument went on, although her car was parked by the front door.
Court documents also note that Stammler told police the alleged victim left the residence for between 30 minutes to an hour, but she did not take that opportunity to leave or call police.
Stammler is charged with attempted first-degree intentional homicide, aggravated battery causing bodily harm and operating a firearm while intoxicated in connection with the shooting, which left her 58-year-old boyfriend injured.
She is being held in lieu of $25,000 cash bond pending an adjourned initial appearance scheduled for June 29.
During her initial appearance, Oneida County district attorney Mike Schiek noted the alleged victim was still in the hospital and had not been questioned. He may also face charges, Schiek said, noting that the man has a pending case in Oneida County Circuit Court with a bond condition prohibiting him from having "abusive contact" with Stammler.
Judge Patrick O'Melia also set a no-contact provision in Stammler's case as well as a prohibition on consuming alcohol. At the end of the hearing, Stammler told O'Melia she was confused as to why the charges were brought against her.
"I was just protecting myself," she said.
Jamie Taylor may be reached via email at firstname.lastname@example.org.
The Northwoods River News | Walker Communications, LLC 232 S. Courtney Street, Rhinelander, WI 54501 | Office (715) 365-6397 | Fax (715) 365-6361
Corporate billing office: The Lakeland Times / Lakeland Printing Inc. | P.O. Box 790, Minocqua, WI 54548 | (715) 356-5236 | Fax (715) 358-2121 Members of the Wisconsin Newspaper Association, Wisconsin Community Papers, Rhinelander Area Chamber of Commerce, Minocqua Area Chamber of Commerce


text:
Located on the Keene/Jay border in the High Peaks region of the Adirondack Park, this property is situated on the banks of the Ausable River, renowned for its exciting fly fishing enjoyment among crystal clear deep pools and wide open rapids. Enjoy 1000± feet of private and exclusive access to this beautiful river with its private beach and swimming hole that exemplifies the Adirondack experience one feels when surrounded by mountains and the North Country environment. The New York State Constitution ensures that the forest preserve lands across the river will forever protect against man made encroachments upon the shoreline of this property.
Originally constructed in 1840, the home was totally renovated in 2005 to reflect Adirondack style living and is offered complete with rustic furniture, assorted cookware, linens, blankets and modern appliances. Should the new owner desire to generate extra income, the property could be used as an excellent vacation rental, that historically has drawn repeat clients all year round.
Home amenities include a living room, eat in kitchen, with a free standing wood stove, pantry, utility and laundry room, two bedrooms and a bunk room that together can sleep eight, and one and one half baths. A covered porch, with Adirondack chairs, provides an area where one may rest and reflect upon the sounds of the river as it flows nearby. Comfort to the rooms is provided by an oil fired forced air heating system. Domestic water comes from a drilled well and is heated by a super efficient, on demand, tankless propane heater. A 24′ x 26′ barn, known as the “Hazard Forge”, housed a nail making business in the 1800’s still stands sound on its stone foundation in its original location on the property.
The 1980 Winter Olympic Skiing facilities on Whiteface Mountain and the quaint Village of Lake Placid with its Olympic venues, excellent shopping opportunities and fine eateries are less than 30 minutes distant. International airports at Albany, New York, Burlington, Vermont and Montreal, Canada are less than two hours away by car. Lake Champlain and the ferries to Vermont are less than 40 minutes to the east.

domain: travel


MOSCOW, December 26, 12:03 /ITAR-TASS/. The Tor-M2U newest anti-aircraft missile systems will be for the first time shown on May 9, 2014, in the Victory Parade in Moscow, Alexander Leonov, chief of air defence troops of the RF Land Forces, told journalists in connection with the 98th jubilee of air defence troops, marked on Thursday.
"It is the first time that the public at-large will have an opportunity to see these combat vehicles in the incoming year on May 9 during a Victory Parade in the Red Square," he said. "As of now, in three military districts, there are troop formations which already have available Tor-M2U systems."
Leonov said the Tor-M2U ensures an all-aspect destruction of air targets resultant of the availability in it of an all-round-view spotting station, a guidance station, and a unit of fire -- a vertical-takeoff anti-aircraft guided missile.
"Such a configuration of the combat vehicle makes it possible to reconnoiter on the move in any kind of terrain and fire at air targets from an unprepared position after a short, 3-5-second, stop," he said. "Besides, a high-capacity computing system ensures a complete automation of combat performance processes with a simultaneous firing by one launcher at four targets in a given sector".


text:
Furthermore, the 3-year overall survival (OS) rate was 89.4% among patients who received drifted trastuzumab and 100% among patients who received non-drifted trastuzumab — a difference that theoretically could be associated with a higher likelihood of death for those who were in the drifted product cohort — but the difference lacked significance (HR, 7.96; 95% CI, 0.95-67.00).The EFS and OS rates were not significantly different between patients who received SB3 and patients who received non-drifted trastuzumab.5
The extension study also revealed that ADCC status was significantly associated with EFS (HR, 2.62; 95% CI, 1.46–4.49; P =.0012), suggesting that the trastuzumab drift may have indirectly impacted EFS.5
A coauthor on the extension study, Dr Lyman, said the reason “everyone” is not “all over” these findings is the fact that this was a retrospective subset analysis; these types of studies (and any conclusions drawn from them) are subject to a higher risk of bias than some other studies that use a more controlled design.
The phase 3 trial initially concluded with 380 patients in the biosimilar group and 384 in the reference trastuzumab group, but only about half agreed to participate in the extension study: 186 in the biosimilar group and 181 in the reference trastuzumab group.5
As a result, Dr Rugo said, “You can’t say definitively that [that] shift in trastuzumab results in a difference in EFS.” Dr Lyman expressed a similar view, adding that it’s unknown whether any patient was harmed as a result of being administered medications from the drifted lots.
The FDA declined to comment on the extension study, saying that the agency does not generally comment on “third-party” studies.
A Genentech spokesperson told Cancer Therapy Advisor that when the “glycan shift” was first identified, Genentech “proactively alerted health authorities” and the investigations conducted by the health authorities concluded that “the new data [do] not provide evidence that indicates a clinically relevant impact on patient outcomes.”
Although the drifted trastuzumab appears to have been restored, Dr Lyman views this event as a “wake-up call” to industry, regulators, clinicians, and patients that these stakeholders can’t let their guard down. He added, “We need to keep a very close eye on these products over time.”
Given the low likelihood that these findings will be confirmed in another study, Dr Rugo stressed that there should be “continuous” analytic evaluations of trastuzumab products to make sure that they align with the expected standards. In fact, in light of their findings, Samsung recommends that the quality profile of the reference product be monitored throughout the “entire” period of biosimilar development.2
“The most critical thing is now we’re all more aware that [product drift] isn’t just theoretical,” said Dr Lyman. “This can happen in reality and in a situation where you’re treating patients to cure them, to eradicate a disease like HER2-positive early-stage breast cancer.”
Disclosures: Dr Rugo reported having received funding from Genentech, the manufacturer of trastuzumab. Dr Lyman reported having initially received payment from Samsung for consulting on the initial trial findings. He was not paid for his contributions to the extension study.
- Pivot X, Bondarenko I, Nowecki Z, et al. Phase III, randomized, double-blind study comparing the efficacy, safety, and immunogenicity of SB3 (trastuzumab biosimilar) and reference trastuzumab in patients treated with neoadjuvant therapy for human epidermal growth factor receptor 2-positive early breast cancer. J Clin Oncol. 2018;36(10):968-974.
- Kim S, Song J, Park S, et al. Drifts in ADCC-related quality attributes of Herceptin®: Impact on development of a trastuzumab biosimilar. MAbs. 2017;9(4):704-714.
- Lyman GH, Zon R, Harvey RD, and Schilsky RL. Rationale, opportunities, and reality of biosimilar medications. N Engl J Med. 2018;378(21):2036-2044.
- Samsung Bioepis. US FDA approves Ontuzant® (trastuzumab-dttb), Samsung Bioepis’ first oncology medicine in the United States [news release]. Incheon, Korea: Samsung Bioepis Co., Ltd. Published January 21, 2019. Accessed November 22, 2019.
- Pivot X, Pegram M, Cortes J, et al. Three-year follow-up from a phase 3 study of SB3 (a trastuzumab biosimilar) versus reference trastuzumab in the neoadjuvant setting for human epidermal growth factor receptor 2-positive breast cancer. Eur J Cancer. 2019;120:1-9.


Chief Douglas Janvrin
3 Morgan Ave.
Newbury, MA 019510
For Immediate Release
Thursday, Aug. 22, 2019
Contact: Jordan Mayblum
Email: [email protected]
Newbury Fire Department Ladder Truck Construction Nearing Completion
NEWBURY — Chief Douglas Janvrin is pleased to announce that he and other members of the Newbury Fire Department will soon conduct an on-site inspection of the department’s new ladder truck.
Members of the Newbury Fire Department will travel to the KME factory in Nesquehoning, Pennsylvania, to carry out a thorough inspection of the department’s brand new KME 103 Tuff Truck ladder apparatus.
Construction of the new truck has progressed well, and the group of Newbury Fire representatives will visit the factory in the coming days to see it firsthand. While there, they will ensure that the truck meets all of the department’s specifications in order to prepare for final delivery of the vehicle.
“This visit is an important part of the process that will ultimately result in our department adding a state of the art piece of equipment to our fleet,” Chief Janvrin said. “We’re all looking forward to adding it to our department so that we can further enhance our level of service to the community.”
Once it passes its inspection, the truck will be delivered to Bulldog Fire Apparatus in Woodville, where it will be lettered and outfitted with equipment prior to final delivery and training.


When How to Get Away with Murder actress Viola Davis stepped on stage to accept her Emmy award, the veteran actress eloquently addressed a major reason why she was the first Black woman to win the Outstanding Lead Actress in a Drama Series award:
“The only thing that separates women of color from anyone is opportunity.”
Ms. Davis’ comments were targeted toward women of color specifically, but her statement has proven itself to be true when it comes to diversity in mainstream comics. There has been a reoccurring discussion about the lack of diverse main characters in comics by major publications. With the success of movies about Iron Man and Captain America, comics are more popular now than ever, but existing and new non-White characters were not being brought to the forefront until webcomics took over the world.
Many comic creators saw the mainstream comic world turning a blind eye to a huge fan base and decided to create their own opportunities via webcomics. Talented artists and writers use the low-cost, low-barrier entry method to supply people with stories that resonate with their experiences as people of color. Comic lovers who are tired of the lack of fair representation from traditional publishers gravitate toward webcomics for simple reasons. One, the comics meet them in the virtual world where they reside. Two, the characters and storylines feature people who look like them.
With the power of social media, webcomics have caught the attention of major media outlets as their followers spread the word about their stories. The massive collection of webcomics cannot be compiled into an exhaustive list, but the following are a sample of series that are causing a shift toward diversity in the overall comic world:
Raising Dion is a brand-new webcomic by writer/director Dennis Liu with an interesting perspective on the life of a superhero. Instead of his story being told from the first-person perspective of the person with powers, readers experience the story through the eyes of a single Black mother. Nicole, a widower, describes life with her 7 year old son, Dion, who has a host of powers including telekinesis and invisibility. In order to keep her life in order and keep an eye on her young son, she films every second of his life. Her already strange world becomes increasingly stranger when she discovers unknown men studying her every move and Dion’s sharpening powers.
The unique premise of the comic has caused it to become an internet sensation. Raising Dion has been featured on a host of websites including The Guardian, Fusion, and Huffington Post and has been widely praised for having black main characters and an accurate portrayal of single motherhood. The media attention has led to an outpouring of support for the creator as well as discussions on innovative ways to position new comic series.
The Life and Times of Abigail Waller
Screenplay writer Kevin Sorrell tried to submit his scripts to Hollywood agencies for years. After relentless rejections, he decided to branch out on his own and pursue a clever idea. Abigail Waller started as an online web series that was meant to have an “Ally McBeal” tone with a cast filled with people of color. However, after only two episodes, the project became dormant until Sorrell decided to throw caution to the wind and bring the idea back as a webcomic in April 2015. Since then, the bi-weekly series has been featured on Black Girl Nerds and OurImage Film & Arts, and applauded by fans for its offbeat humor.
Kevin created an opportunity for himself when doors weren’t opening for him and now he is prepping to independently release a full print comic series called Lupus Moon based on the love he has received from The Life and Times of Abigail Waller.
As more readers gravitate toward web-based comics, the “Big Two” are finally beginning to make steps towards change. News reports recently revealed that Marvel has tapped social/cultural writer Ta-Nehisi Coates and artist Brian Stelfreeze to develop a 2016 comic series around Black Panther (who has a major movie dropping in 2018). Their involvement is a sign that Marvel is beginning to realize the need for diverse creators as well as characters.
DC Comics also dropped a major bomb earlier this year when they announced the return of the Milestone Media and the return of characters of color from the 90s, including Static Shock, Xombi, and Hardware. DC Entertainment co-publisher Jim Lee spoke briefly on the decision and what they hope it accomplishes:
“We couldn’t be more proud and excited about the opportunity to bring the Dakota universe back to DC. This is a huge step forward for us in bringing readers a more diversified lineup as part of the New DC Universe, and we’re anxiously looking forward to telling new stories that are socially and culturally impactful and representative of the world in which we live.”
These fairly recent developments by Marvel and DC proves the companies are paying attention to social media demands and the overall popularity of multicultural webcomics. More now than ever, fans are able to call major comic publishers out when they drop the ball and offer suggestions on ways to improve current comics. And, if they don’t see the changes they demand, fans have the option to find online creators who are passionate about portraying the world through an accurate lens. Patreon, Kickstarter, and other fundraising methods are helping many webcomic creators make a living off of their art and fans are beginning to also speak with their wallets by supporting them. Online comics are indeed effecting positive change in the overall comic world and will continue to influence future trends in character development and diversity both in comics and behind the scenes.
Quote Source: DCcomics.com
Feature Photo Credit: Dennis Lui/Raising Dion
Photo Credit: Dennis Lui/Raising Dion
Photo Credit: Kevin Sorrell/The Life and Times of Abigail Waller


Two levels up in the mall, on the 1st floor you can find the shop nº 35
Located in the heart of Lisbon city centre, Peekaboo is a small shop owned by Trol2000 - a local DJ and also an exceptionally friendly guy who’s ready to help you with new musical discoveries.
The shop specialises in high-quality, rare and used vinyl, with a particular focus on disco, boogie, new wave, soul and world music. You can also pick up DJ accessories such as record bags and needles.
This is the place to go to satisfy your dusty fingers.
- R. da Misericórdia 14, 1200-445 Lisboa, Portugal
- Monday 13:00 – 19:00
- Tuesday 13:00 – 19:00
- Wednesday 13:00 – 19:00
- Thursday 13:00 – 19:00
- Friday 13:00 – 19:00
- Saturday 13:00 – 19:00
- Also Sells
- DJ Gear


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ESTIMATING THE AMOUNT OF THE WASTED WATER DUE TO FAULTY ACTIVITIES IN SOME AREAS IN DHI QAR/ SOUTHERN IRAQ
Because of the poor water situation in Iraq in general and the southern governorates in particular requires prior consideration to find appropriate solutions. In this study، the researchers sought to estimate the amount of waste water in irrational and irrational ways in five vital areas within Thi-Qargovernorate, which are Qalat Suker, Al-Rifai, Al-Shatrah, Sug Al-Shuyukh and Al-Fuhud cities using the questionnaire distributed to citizens. The total amount of water wasted per month in these five areas due to the unemployed faucets is 1752660 liters. Because of the leakage of the water reservoirs without a roving، it is 901906480 liters، because washing the cars with the water hose is 952632 liters and keeping the faucets open during the cleaning of the teeth is 288845180 liters. Khartoum is 23163505 liters. The researchers concluded that very large quantities of drinking water are wasted daily due to erroneous activities by the population in the study areas where 1216620475 (one billion two hundred and sixteen million six hundred and twenty five hundred) liters per month are lost. Given that the average person in developing countries may need about 80 liters per day for all his needs، these amounts would have been wasted if it was used to provide 510000 citizens a day with drinking water
-Al Tuma, H. H. 2018. Water Crisis in Iraq, Causes and Solutions. Scientific report, Al Furat Center for Development and Strategic Studies, Strategic Studies Center, University of Karbala., in Arabic
-www.yourhomegov.au. retrieved 12-9-2018.
-Jwar, A. S., & Neghamish, R. G. (2021). Effect of levels organic fertilizers and kinds of Bio-feritilizers in characterical of two classes of Okra plant (Abelmoschus esculentus L.) growning in the plastic house. University of Thi-Qar Journal of agricultural research, 10(1), 54-69.
-Jwar, A. S., Wahed, M. S. A., & Ghani, S. T. (2021). Study the effect of foliar spraying with Dionyfer and Azomin on the vegetative growth indicators of the leaves of Henna plant (Lawsonia inermis L). University of Thi-Qar Journal of agricultural research, 10(1), 70-78.
-Al-Ansari, N. 2018. Water Crisis Risks in Iraq, Reasons and Ways of Process. Scientific report, Al Jazeera Center for Studies, Al Jazeera Media Network, in Arabic.
-Al-Najdi, S.B. Saleh. 1912. Suq Al-Shuyoukh city. Arabs Language Magazine 6 (2): 251-254 December, in Arabic.
-Shalabi, S.A. 1999. The problem of fresh water in the term of the new international agreement. Journal of International Politics 35 (137): 8-44, in Arabic
-Al-Obeidi, Q.H. 2011. Awareness and aquaculture. College of Basic Education Research Journal 11(1): 340-356, in Arabic
-Othman, A.H. 2005. Islamic principles in environment and development. Journal of Islamic Thought and Scientific Creativity 3(3): 22-38, in Arabic
-Ali, A. M. 1990. History of Suq Al-Shuyoukh City, Issam Press, Baghdad, Iraq, pp. 238, in Arabic
-Omar, M. I. 2006. Water Treatment, Scientific Books House for Publishing and Distribution, Cairo, Egypt, in Arabic.
-Al-Miqdadi, K. 2018. Iraqi Water Crisis in 10 Scientific Researches, Scientific report, Water Electronic Magazine.
-Muaead F. Abbas Abdullah A. Abdullah Nadia N. Haamed. 2018. Effect of the salinity of irrigation water and spraying with selenium in the yield indicators and the qualitative traits for two cultivars of the Okra plant (Abelmoschus esculentus L.) cultivated in greenhouses. Euphrates Journal of Agriculture Science-10(2): 295 - 306.
- Hussein, S.A., Al-joubory, H.R., Sahib, M. M. 2019. Effect of bio-fertilization and salinity levels of irrigation water on the growth and yield traits of wheat. Euphrates Journal of Agriculture Science. 11 (3): 39-48.
- Al-Khafaji, M.J.M. and Al-Janabi, H.Y.A. 2020. Effect of salinity of irrigation water and spraying with selenium and Humic acid on the growth of yellow corn. Euphrates Journal of Agriculture Science 12 (1): 76-84.
- Al- Wotaify A.S. S. and Al-Mamuri Z. A. S. 2019. Bioaccumulation for some heavy metals on the impact of irrigating soil and plant with wastes of Al-Muamirah station. Euphrates Journal of Agriculture Science 11 (1): 22 - 32.
- Al-Qasimi, H. A. A. and Al-Salhi,Th. H. Kh. 2018. The effect of agriculture media and the quality of irrigation water in the
pomegranate leaves content (Wonderful and Salimi cultiars) of some
mineral elements. Euphrates Journal of Agriculture Science 10(2): 124-136.
- Joody, A. T. 2016. Effect of GA3 ,foliar fertilizer growmore and magnetic treated water on growth of apple sapling cv Ann. The third agricultural conference
Jwar, A. S., & Abdul-Wahid, M. S. (2018). Effect of different pollen grain source and chitosan on some physiological and enzymatic characteristics of data palm Phoenix dactylifera L. fruits cv. Alshwethey. Basrah Journal For Date Palm Research, 17(1-2).
Abdul-wahid, M. S., & Jawar, A. (2019). Response of Some chemical, physical and productivity propertiesto date palmPhoenix dactylifera L. cultivation sites. University of Thi-Qar Journal of agricultural research, 8(1).
Abdul-wahid, M. S. (2019). Effect of Spray by Chelated Iron in physical and Chemical Characteristics of Iraqi Banana Musa Paradisica L. Var Sapientum (L.) Oktze Cultivation South Iraq. University of Thi-Qar Journal of agricultural research, 8(1).

domain: agronomy


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The 2021 Volvo Xc70 New Generation Wagon and its distinction for unsullied reliability enable it to be a robust contender within the fading family-sedan section. Its three powertrain choices cowl a diversified range: there’s a fuel-efficient four-cylinder, a potent V-6, and an eco-friendly hybrid. Though the 2021 Volvo Xc70 New Generation Wagon has a compliant experience and proficient dealing with, it trails in performance behind the sportier and turbocharged rivals such because the acclaimed.
What’s New for 2021?
There’s also plentiful customary driver-assistance know-how, together with forward-collision warning, adaptive cruise control and lane-departure warning. The 2021 Volvo Xc70 New Generation Wagon may be suffering from small imperfections, besides, it is the best-executed 2021 Volvo Xc70 New Generation Wagon that Toyota has ever produced.
Engine, Transmission, and Performance
The big change for 2020 is the performance-oriented 2021 Volvo Xc70 New Generation Wagon outfitted by Toyota Racing Development (TRD). This racier Camry rides on retuned dampers supported by stiffer springs that decrease the trip peak by 0.6 inch. Beefier anti-roll bars, further chassis bracing, and wider lightweight wheels wrapped in summer time rubber put together the Camry TRD for the Outdated Nation Buffet 500. The front brake rotors increase in diameter by 0.9 inch and are clamped by dual-piston calipers, and there’s a TRD-specific exhaust system to sound the part. The outside is complemented by a unique aerodynamic body kit, and the interior is wearing purple to finish the look. Previously unavailable, Android Auto functionality is now commonplace in all Camry models.
The 2021 Volvo Xc70 New Generation Wagon is powered by a 5.7-liter V-8 engine paired with an eight-speed automatic transmission. This setup generates 381 horsepower and 401 lb-ft of torque. Full-time four-wheel drive is standard. With a experience high quality that is clean and well-planted, the Land Cruiser delivers comfortable driving dynamics. Its steering really feel is mild, nonetheless, and there’s a truthful quantity of physique roll. Rival SUVs on this value range offer handling that is more rewarding. Despite its beefy exterior, the Land Cruiser is comparatively fast off the road. It’s also able to towing as much as 8100 pounds, which is substantial but still slightly lower than some rivals, such because the Chevy Tahoe and Ford Expedition.
Interior, Comfort, and Cargo
So far as the 2021 Volvo Xc70 New Generation Wagon cabin is anxious, it’s all in regards to the execution, and there is a formidable consideration to element at play. While the cabin isn’t as visually opulent as that of rivals such because the Mercedes GLS-class, it’s dwelling to top-rate supplies. Construct quality is excellent, and knobs and switches transfer with a weightiness that conveys high quality. The front row provides comfy accommodations and commanding sightlines. There’s plenty of room within the second row, but the third row is finest suited to kids. With the usual eight-person seating setup, the Land Cruiser offers 16 cubic ft of cargo space behind the third row and 41 cubic toes behind the second. There’s extra cargo house in competing models just like the Lincoln Navigator, which provides about 20 cubic toes of room to your belongings behind its third row.


text: Senior Jacob Pullen has been cleared for Saturday’s game against Iowa State after sustaining an injury in the second half of Kansas State’s 75-70 win over No. 7 Texas on Monday night. After further medical examination Tuesday, it was confirmed that he has a bruised right hand. However, the injury will not cause him to miss any practices or games. Also, head coach Frank Martin was resting comfortably Tuesday, after undergoing successful arthroscopic surgery on his right knee to repair torn cartilage. It is anticipated that Martin will participate in practice Wednesday and be on the sideline for the Iowa State game.


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Why the DaVinci 1.0 Pro
XYZ printing focus on the entry level 3D printer market. The DaVinci 1.0 Pro desktop 3D printer is like the Da Vinci 1.0A but with added versatility, allowing users greater control over their 3D printing and opening up the possibility of filaments that can be used. It is built to be easy to use with an emphasis on plug’n play 3D printing. You can also add the Da Vinci Pro Laser engraving print head to personalise any of your models.
The Da Vinci Pro 3D printer features
One of the major differences between the Pro and the previous Da Vinci 3D printers is that you can use 3D printer filaments from any manufacturer, it has an open filament system, this together with an upgrade of their XYZware allows you to be able to adjust multiple print settings like: print speed; Print support; retraction settings; extruder temperature. You will have to discover what settings work best with what filament but it means that even speciality filaments can now be used.
The Da Vinci Pro has an Auto Loading filament system for easy changing and installing of filaments.
With it’s new print bed calibration system the onscreen software instructions will give you live feedback on your bed levelling using the DaVinci Pros bed level Detection software.
You can connect to your printer wirelessly, giving you greater connectivity than before.
This XYZ 3D printer has a build volume of 20cm x 20cm x 20cm which is extremely impressive for this price bracket.
It boasts a good sized build area of 20cm3, larger than most in it’s price range. and a range of layer resolutions to give you maximum options for your printing.
Importantly the print area is enclosed with a heated bed. This is great for ensuring the consistency of your printing between jobs and is ideal for both PLA and ABS, helping to reduce warping and improving print bed adhesion. The Da Vinci Pro also features an all Aluminium print bed which gives a better heat distribution and faster heating for reduced print warpage and better print adhesion.
It’s a safe printer too; having and enclosed build area helps protect prying fingers from the hotend and print bed during use making it an ideal choice for schools and the home.
XYZ Pro printing Software
the XYZware Pro software makes it very easy to download and upload designs from and to the 3D printing community. It is very easy to use and will have you printing your first designs in no time. The Pro software gives you the power and versatility to really hone your printing, allowing you to tweak your settings to give you that perfect print.
Da Vinci 1.0 Pro 3D Printer Resources
XYZ Da Vinci 1.0 Pro specifications
Weight & dimensions
- dimensions: 46.8 x 51 x 55.8cm
- weight: 26kg
- Technology: FDM
- Print heads: Single extruder
- Maximum creation size: 20 x 20 x 20 cm
- Nozzle diameter: 0.4mm
- Compatible material: PLA & ABS
- Filament diameter: 1.75mm
- Print surface: heated
- Enclosed build chamber: yes
- Layer thickness:0.1, 0.2, 0.3 & 0.4mm
- Wired:USB 2.0 & Wifi
- Description: XYZware for Pro
- File Types: STL, .3w (XYZ format)
- System Requirements: Windows (7+), Mac OS X (10.8+) – Note: Standard VGA driver on operating system, or a graphics card doesn’t support OpenGL 2.1, may cause unknown error in XYZware.

domain: hobby


I think I started a few things that week! I also ripped out a few projects that I knew I would never get to. I have followed this guideline for a year and it's very freeing. I've ripped out more and I've remained excited about what I'm knitting.
I've also been slowed down by what yarn to knit with. I feel like if I have time to knit I should with yarn I've dyed. Samples for the booth are always a good thing right? But it stops me from knitting. So I'm getting over it and enjoying knitting with what ever strikes my fancy. And I'm still getting some samples done!
Now for actual knitting knowledge. I've learned the basic construction of a shawl and I'm not nearly so scared of knitting them! I think not being pregnant and o getting older has helped my knitting skills. I started knitting Octavia (sorry I didn't wait for you) and I'm a lot more comfortable with the directions and construction. I sort of want to go back and rip out a few that I started and I didn't know what I was doing. We'll see. Maybe I can redeem them. Speaking of shawl, I'm off to knit!


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I finally got these new vessels photographed. I made up some samples for my Ceramic Beads and Vessels class at Bead and Button. We made them at my Miami class last month and they were a hit. We had some really great pieces come out of the kiln. In the class we are making vessels of all types but these beads are starting blocks for many more ideas. My favorite is the top photo....I am going to make more of these for sure.
This is a rattle, it's got metal inside to make noise.
Amphora with lid

domain: design


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Book Description HTML
This book is a compilation of the Rumi Teaches blog posts from 2013 - 2014. The blog seeks to inspire a more wholistic approach to reading and applying what Jalaal ud-Diin Rumi taught through his poetry, stories, and words. Such includes placing his work in the context of Islam, Rumi’s spiritual path from birth to death. This approach also includes the deeper mystical purpose of his work to arrive at the station of realizing the Beloved, the Absolute. This blog is open to all, but with a keen intent for sincere seekers of Truth who embrace the path of the heart.

domain: library


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FROZEN CHICKEN BREAST WITHOUT INNERFILLET, SKINLESS, BONELESS, CALIBRATED,
About the product
A full chicken breast - skinless, boneless, with inner fillet removed
– delivered direct to your freezer. Ready in minutes as the
centrepiece for chicken dishes from every corner of the world.
Discover the secret ingredient at the heart of the world’s most
Naturally high in protein, our chicken is sourced from the world’s finest farms and facilities. You can trust Seara to deliver quality, reliability and flavour in every bite.

domain: food


Antonio Banderas has said that a heart attack he suffered in 2017 was “one of the best things” that happened to him, because of the clarity and perspective he found afterwards.
The 62-year-old Spanish actor discussed the experience in a recent interview to promote his new film Puss In Boots: The Last Wish. In the animated film, Banderas voices the titular feline character, reprising his role from 2004’s Shrek 2The 2007s Shrek the thirdThe 2010s Shrek forever after and the 2011 spinoff Puss in Boots.
The new film finds Puss in Boots learning that he has used up eight of his nine lives and embarks on a journey to find the mysterious Last Wishing Star to restore them. Banderas was asked in a new interview in Radio Times if he could relate to the movie.
“I had a heart attack six years ago,” Banderas replied, per The independent. “It was probably one of the best things that has happened in my life. It was like putting on glasses and seeing what was important.”
“I came back to Spain and started looking at my professional life from a different point of view,” Banderas continued. “So I connect to [the film] in a personal way. I think it’s a beautiful message and I think it was done properly.”
This isn’t the first time Banderas has discussed the impact his heart attack had on his life. The actor made similar comments during a Fresh air interview in 2019, saying, “It just gave me perspective on who I was and it just made the important things [go to] the surface”.
In an interview with The independent that same year, Banderas said confronting his mortality had “made [him] understand life in a deeper, more complex way”, and led him to “[detach] from things that are no longer important”.


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A handful of ingredients is all you'll need for this sweet and fluffy salad from Sandy Ward, Madisonville, Texan. Your gang will love the combination of canned fruit, mini marshmallows and whipped topping, and you'll love how simple it is to assemble.
This unique take on hot chocolate is perfect for Halloween. The creamy white chocolate mixture is thick and satisfying. Add a few drops of peppermint extract if your crew would prefer a minty drink.—Taste of Home Test Kitchen


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The natives were restless that afternoon. Running around their primitive structures with wild abandon, screaming unintelligible words that caused my blood to curdle. Plumes of dirt puffed up from under their stomping feet as they danced around me with jerky movements that made no sense.
Dread flooded my heart.
As the group circled around I recognized one of them. I’d known him for two years and he’d shown me mercy in the past. I reached out a hand but he ignored me, caught up in the energy of the ritual.
Behind him a girl caught my attention and we made eye contact. For a second we were connected and I thought—hoped–I had another chance to escape this madness. My hopes were dashed when she opened her mouth to let out a shriek that sent shivers up my spine. Turning on her heels, she ran in the opposite direction and the others followed, crashing into one another as they righted themselves with the new rotation.
I looked around at the other parents and a collective sigh escaped us. It was going to be a long day at the playground.
There was only one gift under the tree.
Wrapped in shimmering gold paper and tied with a sparkling red bow, it was a package unlike any other the children had ever seen and they wondered, Was it for them?
The bravest among them stepped forward to lift the lid and when she did a rainbow slipped out; its light swirling and curling around the children’s heads. Music from a thousand instruments floated out with the light; each playing its own special song but blending together so beautifully. All the children crowded around to look inside and what they found was magic.
A beautiful orb floated weightlessly in the center of the box and as it spun slowly around a million stories were revealed to the children…
Big boys and girls who explore secret worlds,
Kings and queens and dinosaur things.
Wizards and witches, fairies and gnomes,
Faraway places like Paris and Rome…
Big and small, these stories had all…
…except someone to read them to the children. Will it be you?
This Christmas I encourage you to give a magical gift to a child by reading to them. It just may be their most special moment of the season.


UVision-USA Corporation is a wholly owned company of Israel-based UVision Air Ltd.
UVision USA delivers combat-proven Unmanned Aerial Loitering Munition (ALM) Systems providing militaries around the globe with precise and effective operational attack capabilities. Its innovative, cost-effective ‘HERO’ series of Aerial Loitering Munitions are based on cutting-edge technology and extensive field experience. The ‘HERO’ Systems provide high precision strike capability. The unique aerodynamic platform is designed for extreme flight and attack profiles for the most precise strike in their class.
UVision-USA has US-based production and training center in Stafford County, Virginia where it fulfills contracts awarded by the US Government and international customers for the manufacture and assembly of loitering munitions.


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H.Y.P.P. stands for Hyperkalaemic Periodic Paralysis. It may also be called Hyperkalaemic Polymyopathy. Hyperkalaemia means too much Potassium in the blood and this condition is a disorder of Potassium metabolism.
H.Y.P.P. is a genetic disorder caused by a defect in the Sodium channel in muscle cells of affected horses which facilitates the passage of Potassium into the cell and Sodium out of the cell. The mutation causing the defect originated in a quarter horse stallion called Impressive and affected horses are related to that stallion or his descendants. Around 4% of quarter horses are now affected.
The disease causes abnormal flows of sodium ions into muscle cells precipitating waves of electrical activity and contraction of those cells. Potassium is the main electrolyte ion inside cells whereas sodium is mainly in the extracellular fluid. Symptoms of H.Y.P.P. include trembling, cramps, muscle fasciculation (twitching) often seen first over the flank and ribs but possibly affecting other muscle groups as well. Some horses become lethargic and have very low heart rates. Signs may mimic colic and the third eyelid may become everted. Horses can become recumbent or assume a sitting posture. Foals may show signs similar to respiratory obstruction. In the severest cases paralysis of respiratory and heart muscles can be fatal.
Immediate veterinary treatment is by administration of intravenous calcium and glucose and possibly a specific diuretic which increases potassium excretion in the urine. Nutritional management involves reducing potassium intake by reducing forages, especially legumes like Lucerne and selecting feeds based on their potassium concentration under veterinary supervision.


KOCHVILLE TOWNSHIP, MI
— With just more than one week to go, the Kochville Township Cabela's Outpost store is in its final preparations for opening.
More details have been released for Cabela's Thursday, Feb. 14 grand opening and attendees can expect giveaways, outdoor experts and, probably some long lines, too.
Cabela's grand opening events in other states have even led to customers camping out in the parking lot.
Festivities will kick off with a 10:45 a.m. ribbon shooting by professional archer and Cabela's pro-staffer Tom Nelson.
The 43,000-square-foot store, located at 5202 Bay Road in Kochville Township, is packed with camping, hunting, fishing and outdoor supplies, and will officially open to the public at 11 a.m. on Valentine's Day.
The first 500 customers in line on opening day will receive a Cabela's gift card valued between $5 and $250, the company said in a release. The first 50 people through the doors at 8 a.m. Friday will receive a Scout tackle bag.
On Saturday, doors open at 8 a.m. and the first 50 people will receive a Cabela's cap. When the doors open at 10 a.m. on Sunday, the first 50 people will receive a Cabela's gift card valued between $5 and $100.
During the opening weekend, any customer who is 18 or older is eligible to enter for a $1,000 shopping spree.
Outdoor experts and Cabela's pro-staffers will be at the store throughout the weekend. Michigan State University's Sparty will make an appearance, too, at 11 a.m. on Thursday, Feb. 14.


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Commissioners move November meeting
The board also voted to move its second November meeting to 5:30 p.m. Nov. 13. That will be the only Watauga County Board of Commissioners meeting held this month.
All meetings are held at the Watauga County Administration Building at 814 W. King St. in Boone. For more information, call (828) 265-8000.


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Cat abandoned under fish tank at Petco gets adopted. Now she loves hanging out in sinks
This kitty and her family were abandoned in a box beneath the fish tanks at Petco. Luckily, some kind hearted people decided to take them in.
"This cat was abandoned under the fish tanks in a Petco. I adopted her, and now I wake up to her in my sink many mornings," Noexit007 shared on reddit.
Jingles in her favorite spot!
"In the days leading up to Christmas, this beautiful kitten (now cat), and 2 sisters + mother were left in a box under the fish tanks in the fish section of a Petco right before closing. They were never able to identify who abandoned them there. Perhaps it was someone who's cat had kittens and they felt they could not care for them, or some such thing.
We ended up taking in her and her sister, while the mother and other sister were taken by another family. I always found it amusing that this little one ended up loving water and often sleeping in the tub or sink since she had been found under fish tanks."
Here's Jingles and Joy :)
"Here they are together watching a "guest" warily in the house (the guest being a friends dog). Sister is in the back up higher."
Jingles and Joy are living a happy house cat life - and their Mom (Noel) and other sister (Jangles) are doing great as well!
What a happy rescue :)
Commentscomments powered by Disqus
Happy Mother's Day from the cat!
He wasn't much of a cat guy until he found a crying kitten outside...
Happy Cinco de Meow!
Veterinarian shows us how to pick up a cat like a pro
Cat brings flowers to her neighbors everyday from her garden
He used to hate cats but is now the ultimate cat dad thanks to this special kitty
Kitty has a permanent creepy smile and you'll love it (Gallery)
Did you know that big cats like laser pointers too?
This video perfectly sums up growing up with an older sibling
Man finds a genius way to play with his cat and dog at the same time

domain: pet


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Tin roof farmhouse specializes in eclectic vintage chic design.
Brown tin roof farmhouse.
Sheet metal metal roof panels 12 ft.
Landscaping throughout the front yard is built to endure intense.
See more ideas about house exterior farmhouse exterior house.
Modern ranch surprise az.
The dark paint finishes and white surfaces enhance the home s historic country profile and complement its river rock foundation.
Dec 5 2019 explore d white s board farmhouse roof on pinterest.
10 pet friendly minimum stay from 2 night s bookable directly online book vacation rental 791090 with vrbo.
Board and batten siding and a metal roof honor the farmhouse architecture that existed before renovations started while dark wood clad windows and posts introduce a taste of modern flair.
Internet air conditioning pets welcome fireplace tv washer dryer children welcome parking no smoking heater bedrooms.
White trim white siding and white railings give this farmhouse spick and span appeal.
I m guessing that while the tin roof looks white it s really a light grey to match the window shutters.
Choose gray blue green black or white house colors.
Light grey tin roof who knew.
The urban farmhouse in this photo is painted dusty green to harmonize with the green roof.
Metal roof accents for a touch of modern drama.
Have been lovingly handcrafted or previously loved with lots of patina stories to tell.
Go with brown tan yellow or white house colors.
On the first floor you will find a spacious living room kitchen queen br single b.
Architectural details are accented in off white and burgundy.
I think because of the gorgeous set of rich brown doors featured underneath the covered porch.
The home has many updates.
This historic austin farmhouse includes the original 565 square foot structure which is now the front entry and a two story addition.
The ahren s key design features.
Modern farmhouse with a colorful exterior aldie va.
Metal roofing 25 30 in.
Beautifully updated country home.
Paved road 250 avg night jefferson amenities include.
We love reclaimed natural unexpected pieces.
Jun 19 2020 entire home apt for 225.
Noteworthy farmhouse design elements include.
All of our vintage rentals.
Vintage luxe to woodland bohemian everything in between.
A black painted gable vent and charcoal gray steps take their color cue from the home s metal roof.
How about gray black or brown house colors.


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Organic Micellar Solution Make-Up Remover 200ml
Natural & Organic Micellar Cleansing Facial and Eye Makeup Remover
Micellar cleansing facial and eye makeup remover contains more than 95% of the ingredients of natural origin. Contained ingredients protect the skin from losing moisture, soothe irritation, act as an antibacterial. Has anti-inflammatory effect, anti-allergic and rejuvenate. The skin become refresh with mat finish.
Rice protein - moisturizes, nourishes with minerals, softens, soothes and mattifies the skin.
Lotus oil - keep youth and freshness of the skin.
Rose oil - regenerates, improves the shape of the face and eye contour. soothes wrinkles.
Indication: All skin types
Direction for use: Apply the product to a cotton pad and wipe your face, eye area and lips. No rinsing required.
Ingredients: Aqua, Glycerin, Sea Water, Organic Bidens pilosa Extract, Prunus Amygdalus Dulcis Hydrogenated Oil, Hydrolyzed Rice Protein, Nelumbo Essential Oil, Rosa Damascena Oil, Sodium Cocoamphoacetate, Sodium Benzoate, Potassium Sorbate, Sorbic Acid.

domain: chemistry


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“Before you dive into my waters, you should know I love deep.” ~ Betty Larrea
I am often asked by people—who were in the beginning phases of a relationship or already deeply committed to another person—why the other person walked away and gave up on the relationship.
There are no easy answers, nor are they ever the same. We all choose to walk away from things for a variety of reasons, which are personal to us. But I am a big believer in soul connections and that nothing is a coincidence in life, so I believe that each of those relationships was meant to be something for both parties involved.
One of my spiritual mentors calls the walking away from a relationship a “forfeiture.” It’s when the universe, God, or whatever you believe in brings two people together with the intention and hope that they will take the opportunity to create something together—and then one person withdraws prematurely.
It was not an accident or blind chance that we’ve met.
That person was brought to us because we were asking for what they had to offer in some way, whether it was through prayers, through the energy we were sending out or even through our thoughts, which we may have never verbalized to anyone.
But sometimes we don’t recognize what it is or what it’s meant to be right away and we give up on it too soon. Maybe it looked different than we thought it should. Maybe it was taking too long to get off the ground, and we lost interest and patience. Maybe we were going to have to put a little work into it to create what we wanted, and in today’s world most of us don’t want to have to work at anything…especially a relationship. We want and expect it to be easy.
So in turn, without even realizing it, we “forfeit” the opportunity given to us to create something we actually wanted. And that’s our choice. We can move on and tell ourselves, “It just wasn’t meant to be.”
But for the person who didn’t forfeit and throw in the towel prematurely, the challenge is to not personalize it and make it about us. Although it’s incredibly difficult to not feel rejected, it’s important that we understand it truly isn’t about us but about the other person’s readiness and willingness to meet us where we are.
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domain: literature