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RALEIGH — Some Senate Republicans appear to want another showdown with Gov. Pat McCrory over a state board that hears final unemployment appeals and his appointments to the panel. The Senate Finance Committee recommended to the whole chamber Wednesday a ...Read More »
NC State News
RALEIGH — North Carolina’s tax collections this year are expected to come up $271 million short of what’s needed to cover the $21 billion state government budget, economists at the General Assembly and Gov. Pat McCrory’s administration say. They released a ...Read More »
RALEIGH — House Speaker Tim Moore says he’s unsure why a proposed constitutional amendment seeking restrictions on government seizure of private property has died in the Senate each time one has passed the House. But Moore says he’s hopeful the ...
Tagged with: NC House eminent domain billRead More »
RALEIGH — Senate Republicans say their bill to rework North Carolina’s gasoline tax will provide a short-term break to motorists while making road-building revenues more stable. Opponents argue it’s just a tax increase in disguise. The full Senate meets Wednesday ...Read More »
WILMINGTON — Several beach communities in southeastern North Carolina are starting to build or are considering hardened structures that they hope will slow shoreline erosion. The StarNews of Wilmington reports (http://bit.ly/18VziRO) crews are pumping sand on Bald Head Island before construction of a ...
Tagged with: beach communities terminal groinsRead More »
ROCKY MOUNT — The board of directors of the Golden LEAF Foundation says it’s reserved $50 million to provide support for the location of an automobile manufacturing facility in North Carolina. The foundation announced the move on Thursday. Board chairman Johnathan Rhyne ...Read More »
RALEIGH — Gov. Pat McCrory praised fellow Republican lawmakers Wednesday night during his second State of the State address for their partnership the past two years, saying that has led to lower unemployment and tax rates and accelerated debt repayment ...
Tagged with: Gov. Pat McCrory State of the StateRead More »
RALEIGH, N.C. (AP) — North Carolina House members are again pushing for a constitutional amendment reinforcing limits on state and local government to take private property against the owner’s will. A House judiciary panel Wednesday recommended to the full chamber ...Read More »
FAYETTEVILLE – A Fayetteville landmark, the Prince Charles Hotel, is getting an $11 million makeover and conversion to apartments and retail space. Media outlets report that the new owners, Michael Cohen and his fellow investors in Prince Charles Holdings LLC, ...Read More »
CONCORD — Using a nostalgic locale as his backdrop, Gov. Pat McCrory said Friday that he would propose restoring tax credits for historic homes and businesses when he addresses North Carolina lawmakers in his State of the State speech. McCrory made his proposal ...Read More »


text: The Bruised Orange Theater Company expects too much, asking audiences to show up three times to see all of Clint Sheffer’s episodic play–especially when the first installment is so uninspiring. The characters in this work about people forming a theater company all have their distinctive tics. But as directed by Mark Spence, the opening hour is vague and drawn out, merely introducing an egotistical playwright and his many love interests, among them a high-strung new helpmate (Caren Evers, delivering much-needed energy) and two old flames: the cofounder financing the venture (a charismatic Alison Connelly) and an anxious actress who instantly draws the attention of a kind, awkward actor. Sheffer’s concept is creative, but it won’t work if he can’t generate enough interest for audiences to return for future episodes. Through 6/6: Mon 8 PM. Episode one runs 4/11-4/25; episode two 5/2-5/30. On 6/6, both episodes are performed together, along with a third. National Pastime Theater, 4139 N. Broadway, 773-329-1088. $10-$12.

domain: entertainment


text:
Cox's Bazar Correspondent, bdnews24.com
Published: 2020-08-11 17:52:04 BdST
"They are the witnesses in the case started over the incident. They were arrested over their involvement in the murder," said Ashik Billah, director of the RAB's legal and media wing.
The elite police unit produced the three men before a Cox's Bazar court on Tuesday afternoon to seek permission to interrogate them in remand, according to the court police's Inspector Pradip Kumar Das.
The arrestees are Md Nurul Amin, Md Nezamuddin and Mohammed Ayaz, who were apprehended from the Marishbunia area under Teknaf's Baharchhara Union on Monday, said Wing Commander Azim Ahmed, captain of RAB-15 Cox's Bazar Battalion.
The RAB has sought permission to grill them for 10 days but a timeline for the application hearing is yet to be confirmed, said Inspector Pradip.

domain: news


text:
Elkins’s Fraulein Maria is better than a Broadway showNovember 14, 2009
How do you solve a problem like Maria? Or: Why didnt the nuns think of this?MERILYN JACKSON
Broad Street Review
Nov. 14, 2009
In Doug Elkinss gleeful Fraulein Maria, it takes three Marias two women (one Asian, one presumably Caucasian) and a black gay guy (also presumably) to make this most diverse version of the much-loved but squeaky clean and very white movie, The Sound of Music.
Though the two female Marias remain demure, the delightful Kevin Fitzgerald Ferguson (as the male Maria) makes some funky and some feminine moves of the erotic, if cute, kind, especially in a goofy duet with Devin Buchanan. A fourth Maria makes a cameo appearance in the form of a hand puppet.
Overall, the hour or so dance spoofs the film in 11 adroit vignettes while the choreography concocts a heady mix of homage to some of the great choreographers of the recent past, with a twist of hip hop. Idiomatic moves from Martha Graham, Merce Cunningham, José Limon, even George Balanchine were lightly brushed in. Audience members in the know caught many of these references and laughed appropriately.
Hoodied nuns, who doubled as the von Trapp children, danced with an exaggerated bent wrist here, windmilling arms there, and synchronized torso-bending swoops everywhere.
After the emcee warmed up the audience with the Do Re Mi song (each section singing a vowel), dancers stretched fabric over themselves to suggest the Alpine scenery. A very funny bit had the emcee pull a white scarf from a plant in the audience to cover a mountain in snow.
But the show really took off when the dancing commenced and never flagged through to the finale. Though Doug Elkins & Friends is largely a pick-up company of dancers, this current 13-strong crew is well matched, and all performed with even expertise.
But two male solos stood out. The strikingly sinuous dancer Scott Lowe was last seen here in May, well paired against Paul Struck in Miro Dance Theatres Spooky Action. As the Captain (the von Trapp childrens father), he more or less stands around, elegantly passive while watching the others dance out the story. He enters and exits until the moment he takes center stage, undulating first his upper torso, then his arms, popping and locking against the music, ending with a beautifully slow rotation of his head.
Doug Elkins, a master mixer of hip hop and modern dance, took the explosive final spotlight in a hoodie and basketball shorts. To Climb Every Mountain, he high-stepped in place while shooting hoops, blessing himself, jiving and gesticulating in alternating rude and benign moves in such rapid succession that I couldnt allow myself a blink.
Elkinss Fraulein Maria is better than any Broadway show Ive ever seen. It lets the movement speak for itself, forever solving the problem of Maria.


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Crunchyroll Games has officially announced the pre-registration event for their new mobile game which will soon be released for western countries, yep this game is titled Mitrasphere.
Mitrasphere is a social co-op MMO game that was previously released in Japan in 2017 and has received 800,000 player pre-registrations and 7 million total installs.
The Mitrasphere is a world where a great ocean covers the sky. Gold crystals descended from the faint tree in the ocean sky, changing the lives of everyone and everything. This is the story of those who are cursed by fate and their decision to rise up against them.
Players can explore the world of the Mitrasphere in groups of up to five players to defeat powerful bosses and find legendary weapons during their adventures.
Features in this game:
- Dazzling Art-style: The World of Mitrasphere delivers a luxurious gaming experience through quality art-style inspired by classic JRPGs.
- Social RPG: Mitrasphere extends immersive social experiences with its emphasis on co-op play and environments that enhance interaction between players.
- Unlimited Customization: Players can freely swap between classes, weapons, avatars, and more throughout the game.
This mobile game will be available in the United States, Canada, Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Guyana, Paraguay, Peru, Suriname, Uruguay, Venezuela, Mexico, Australia, New Zealand, United Kingdom, Denmark, Finland, France. , Germany, Ireland, Norway and Sweden.
Pre-registration click HERE
Read more articles related to other mobile games on the mobile game information website FajarYusuf.Com.
Follow Facebook Fanpages and Google News FajarYusuf.Com so you don’t miss any updated information!


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هیچ محصولی در سبد خرید نیست.
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A great deal of people donвЂ™t notice that their state allows them getting a number of these forms of safe online pay day loans, even while long as they truly are having an EFT (electronic fund transfer) system. Many individuals try not to notice that banking institutions have actually these devices aswell.
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You should do it, though it can be done to acquire online loans that are payday.
While there are numerous types of online pay day loans, every single loan need to be provided with care because a lot of people might take advantageous asset of their debtor.
It is imperative that you hand out as little information as you can so that the company will not need to perform hard to discover anything about you personally whenever youвЂ™re obtaining the loan, then. Make certain you only give because much information as feasible in relation to your very own history, your banking reports, plus your own.
The fact men and women have begun utilizing internet payday advances being safe demonstrates that a will get the task done and make certain it really is much more simple for people to get the cash they require, when they want it. These are generally assisting those who find themselves experiencing financial difficulties, and they’re letting them have more assistance.

domain: finance


text:
Full Size Version
Making Sense of U.S. Household Net Worth
Once Upon a Goal
Do you know how to set up your financial goals for success? This knight does.
Buying vs. Leasing a Car
Whatever your relationship with your car, it may eventually come time for a new one. Familiarize yourself with your options.
Your Cash Flow Statement
A presentation about managing money: using it, saving it, and even getting credit.

domain: economics


Microfabricated Atomic Magnetometers and Applications
John E. Kitching, Svenja A. Knappe, Vishal Shah, P Schwindt, William C. Griffith, Ricardo Jimenez Martinez, Jan Preusser
We describe recent work at NIST to develop compact, sensitive atomic magnetometers using a combination of precision optical spectroscopy, atomic physics and techniques of micro-electro-mechanical systems (MEMS). These instruments have sensor head volumes in the range of a few mm3 but are capable of sensing magnetic fields of a few pT/√Hz in a shielded, low-field environment. We discuss design, fabrication and testing of several of these devices and propose several applications for which such instruments might be of use.
magnetometer, magnetic field sensor, micromachining, photonic, chip-scale
, Knappe, S.
, Shah, V.
, Schwindt, P.
, Griffith, W.
, Jimenez, R.
and Preusser, J.
Microfabricated Atomic Magnetometers and Applications, Proc. 2008 IEEE Freq. Cont. Symp., Honolulu, HI, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=842507
(Accessed September 24, 2023)


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- Store Pickup available at checkout for select items. Pickup your order at a store of your choice.
- This item qualifies for free shipping when you spend over $89.


text:
Traveling to Singapore for business, vacation, or as a tourist and looking for the ultimate travel experience with top-notch service? We all know that flying can be somewhat chaotic, even for the most seasoned travelers.
AssistAnt can help! We can set up your transportation to SIN Changi Airport, Singapore, and assist you with all check-in procedures up until the gate of your flight using priority counters.
We can help you get through security, check-in, and immigration quickly so you won’t have to worry about standing in extremely long lines for either your flight or immigration.
First- and business-class passengers can also be escorted to the lounge or the gate by one of our employees.
We are here to make sure your trip, whether for business or pleasure, goes off without a hitch, from airport assistance to restaurant reservations!
Assist-Ant also provides Expedited VIP Services at SIN Changi Airport all the way from Singapore to any destination around the world.
Our experienced team of professionals is available 24/7 and can assist you with a variety of services, ranging from arranging private jet flights to ground transportation, hotel bookings, and more!
With our hassle-free approach, we make sure that your journey at SIN Changi Airport is comfortable and enjoyable. Whether you are traveling for business or pleasure, we are here to provide an unforgettable experience.
When you travel with us, you can rest assured knowing that your trip will be stress-free and luxurious! Let us take care of all your needs so that you can concentrate on what matters most – enjoying every moment of your journey!
What Are Expedited VIP Services at SIN Changi Airport?
Expedited VIP services are designed to help you get the most out of your time.
These services provide VIPs with access to priority queues, personalized customer service, and other benefits that will help them get their needs met quickly and efficiently.
Whether it’s booking flights or ordering tickets for a special event, expedited VIP services are tailored to meet the unique needs of each client. With expedited VIP services, you can skip the waiting game and get right to enjoying the perks of being a VIP!
From preferred seating at popular venues to private jet charters, these services can make it easier than ever before for you to enjoy life’s luxuries – no matter where in the world you may be! So don’t wait — take advantage of expedited VIP services today and enjoy the best of what life has to offer!
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Finally, some companies offer exclusive deals and discounts to those using expedited VIP services. These special offers can make it even easier for you to enjoy the luxuries that come with being a VIP. Whether you’re a business or an individual, it pays to take advantage of these exclusive benefits.
So if you’re ready to experience the best that life has to offer, then consider investing in expedited VIP services and start enjoying the perks today!
Meet and Greet At Changi Airport VIP Services from Assist-Ant!
There are times when you just want an extra touch of luxury and a hassle-free journey. That’s why Assist-Ant has partnered with Changi Airport Singapore (SIN) to bring you the best in VIP services. Our professional team is here to make your Changi Airport experience truly memorable.
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Luxury Transportation Services at SIN Changi Airport in Singapore
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You’ll also get exclusive privileges like priority check-in, baggage handling, expedited immigration clearance, complimentary refreshments, and more!
What are the best tourist spots in Singapore?
If you’re looking for a great vacation spot, Singapore is the place to be! There’s something for everyone here, from breathtaking beaches and lush gardens to amazing nightlife and delicious cuisine.
Here are some of the best tourist spots in Singapore:
1. The Marina Bay Sands Skypark – Located at the top of the iconic Marina Bay Sands Hotel, this Skydeck offers stunning views of the city skyline and features an infinity pool with a 150-meter (492-foot) long edge that overlooks the bay.
2. Gardens by the Bay – This expansive garden brings together two nature parks – Bay South Garden and Bay East Garden – filled with exotic plants, flowering trees, tranquil lakes, sculptures, and educational greenhouses.
3. Singapore Zoo – Located in the northern part of the city, this popular attraction is home to over 2,500 animals from over 300 species and offers plenty of opportunities for wildlife viewing and interactive experiences with some of its furry inhabitants.
4. Clarke Quay – This bustling riverside precinct is a great place to head when night falls and the neon lights come on. Enjoy the vibrant atmosphere as you explore bars, restaurants, clubs, and shops along its winding waterfront promenades.
5. Universal Studios Singapore – An absolute must-do for movie fans, this world-class theme park boasts 24 attractions plus seven themed zones! Enjoy rides inspired by your favorite blockbuster hits such as Transformers and Jurassic Park or take a spin on the classic carousel.
No matter what you’re looking for in a vacation, Singapore has something to offer and these are just some of the many amazing tourist spots that this city has to offer.
Did You Know That?
- SIN Changi Airport Has The Biggest Slide In Any Airport
For every ten dollars spent at Changi Airport, guests are given free access to the 12-meter slide. Alternatively, visitors can try out the smaller slide for free before paying to utilize the larger slide.
- Free Tours Of Sights Are Available At SIN Changi Airport
Visitors to Singapore can take a free, 2- to 3-hour tour. This excursion, dubbed “The Heritage Tour,” travels through Chinatown, Little India, Kampong Glam, and Merlion Park five times each day.
The City Sights Tour, an alternative choice, brings guests past the Marina Bay Sands, Garden by the Bay, Singapore Flyer, and other magnificent spots.
- There Is A Swimming Pool And Jacuzzi At Changi Airport
While waiting for their flight, guests can pay a charge to use the rooftop pool and jacuzzi. The Aerotel Transit Hotel’s first terminal has a pool that is open from 6 AM to 12 AM.
Are you traveling through SIN Changi Airport?
If you’re looking for the best VIP Services at SIN Changi Airport, look no further than AssistAnt Global Concierge. We provide our clients with priority access and a wide range of luxury services to make their travel experience as smooth as possible.
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From personalized assistance at the check-in counter to a reliable transfer from the airport itself, we take away the hassle of having to handle every step of your travel process.
All our services are tailored for VIPs who want an exceptional traveling experience that exceeds all expectations.

domain: travel


text:
The Malmö Festival is the warm, friendly and sustainable festival taking place for one week, every August since 1985. Right in the heart of the city you will experience everything from groundbreaking art, music and culture to a variety of food that reflects the intercultural vibes and people of Malmö. Winnder of a Greener Festival Award.
Two of our Birmingham correspondents, Flo & Jolly Bailey, review Tyrone Huggin’s critically acclaimed story of an elderly Caribbean beekeeper and...
Tony Wrench shares his many years of experience, plus photos and drawings of his roundhouse, that has cost just £5,500. Updated to 2014.


text:
|Molecular Vision 2007;
Received 12 March 2007 | Accepted 17 August 2007 | Published 27 August 2007
Embryonic expression of the optineurin (glaucoma) gene in different stages of mouse development
1Molecular Ophthalmic Genetics Laboratory, Departments of Surgery and 2Pharmacology, University of Connecticut Health Center, Farmington, CT
Correspondence to: Mansoor Sarfarazi, University of Connecticut Health Center, Molecular Ophthalmic Genetics Laboratory, 263 Farmington Ave., Farmington, CT, 06030-1110; Phone: (860) 679-3629; FAX: (860) 679-7524; email: firstname.lastname@example.org
Purpose: To analyze optineurin (Optn) gene expression in various embryonic stages of mouse development by whole mount in situ hybridization.
Methods: FVB/NcrlBR mouse embryos (10.5 and 13.5 dpc) were collected by timed breeding experiments. A 712 bp Optn cDNA fragment was amplified by PCR and cloned into a transcription vector pCR®II-TOPO®. Digoxigenin labeled sense and antisense RNA probes were generated by in vitro transcription. The labeled RNA probe was localized using an anti-digoxigenin antibody conjugated with alkaline phosphatase. Colorimetric detection was performed with substrate solution containing, 4-nitro-blue tetrazolium chloride (NBT) and 5-bromo-4-chloro-3-indolyl phosphate (BCIP).
Results: This study revealed that the developing eye represents a major expression site for Optn. At both 10.5 and 13.5 dpc a strong specific expression was detected in the outer layer of the optic cup (future pigment layer of the retina). This is in contrast to the expression of another glaucoma gene, Cyp1b1, the expression of which at this state is only limited to the inner (neural) layer of the optic cup (future nervous layer of the retina). Inspection of sections from the cephalic region of whole mounts also revealed limited Optn staining in the lens as well as in the optic nerve. A second Optn expression domain was detected at the base of the developing forelimb. The biological significance of this observation is not clear and remains to be determined.
Conclusions: Eye and forelimb were identified as two major sites for expression of the Optn gene. These findings suggest that Optn expression is triggered during early stages of eye development. Expression of the Optn gene in ocular tissues during mouse embryogenesis correlates with the presence and distribution of the optineurin protein, as previously reported in adult ocular tissues. These findings are also in agreement with the predicted function of Optn protein in the eye and the role of its ortholog in human glaucoma. Further investigations are required to determine the molecular mechanisms of Optn in the developing murine forelimb.
Glaucoma is one of the leading causes of blindness worldwide [1,2]. The disease is caused by gradual degeneration of retinal ganglion cells and secondary loss of axons that carry visual information from eyes to the brain. Our previous studies revealed that human mutations in the optic neuropathy inducing protein (Optineurin; OPTN) gene are associated with the GLC1E-linked  primary open-angle glaucoma (POAG) phenotype . Our further studies on optineurin cloning, with genomic and protein characterization in both mouse and Macaca mulatta showed that both OPTN and its encoded protein are evolutionary conserved [5,6]. As the mouse is a well-established animal model for study of mammalian development, this study was designed to investigate the spatial and temporal expression of Optn mRNA during various stages of mouse embryogenesis by in situ hybridization.
Male and female FVB/NCrlBR mice were purchased from a commercial breeder (Charles River Laboratories, Wilmington, MA). For timed mating experiments, breeding units (one male and two females) were set at 3:30-4:00 PM. Inspection for a vaginal plug was performed before 9:00 AM on the following day. For staging purposes, the day that a vaginal plug was observed was designated as 0.5 days post-conception (dpc). Embryos were dissected from pregnant mice at eight stages of their development between 8.5 to 13.5 dpc. Embryos were freed from extra-embryonic membranes, rinsed immediately with phosphate-buffered saline (PBS), and fixed overnight in fresh 4% paraformaldehyde in PBS at 4 °C. The next day, they were dehydrated through a methanol series (25%, 50%, 75%, and 2X 100%) and stored in 100% methanol at -20 °C. All animal manipulations were conducted in accordance with the Public Health Service Policy on Humane Care and Use of Laboratory Animals and were approved by The Animal Care Committee (ACC) of the University of Connecticut Health Center.
In situ hybridization
The in situ hybridization protocol used in this study has already been described in detail [7,8]. Briefly, a 712 bp Optn-specific cDNA fragment, corresponding to amino acid residues 83-320 (GenBank AY071834) was amplified by the PCR primers 5'-GCC TGT TGT TTG AGA TGC AA-3' and 3'-TGT GCC TCT TGA AGC TCC TT-5' and subcloned into the pCR®II-TOPO® transcription vector (Invitrogen, Carlsbad, CA) according to the manufacturer's protocol. Antisense and sense RNA probes, labeled with digoxigenin-UPT, were generated by in vitro transcription of linearized plasmids with SP6 and T7 RNA polymerase (Roche Molecular Biochemicals, Mannheim, Germany) according to the protocol supplied by the manufacturer. The digoxigenin-labeled RNA was localized using a Fab fragment from a sheep anti-digoxigenin antibody, conjugated with alkaline phosphatase. Colorimetric detection of the digoxigenin-labeled probe was performed with substrate solution containing 350 mg/ml of nitroblue tetrazolium (NBT) and 175 mg/ml 5-bromo-4-chloro-3-indolyl phosphate (BCIP). For sectioning, the whole mounts were fixed with 4% paraformaldehyde at 4 °C overnight, washed several times in 1X PBS and, equilibrated overnight in 30% sucrose in PBS. Next, the embryos were mounted on cryostat chuck with Tissue Tek® OCT (Sakura Finetek U.S.A., Inc., Torrance, CA). Sections of 20-50 μm were cut on cryostat and mounted under a coverslip with Gel/MountTM (Biomeda Corp., Foster City, CA).
In order to decipher the Optn gene function, we used nonisotopic whole-mount in situ hybridization of mRNA on a series of murine embryos and investigated Optn expression patterns during early embryogenesis. Inspection of the whole-mount embryos reveled strong and well-delineated Optn expression domain in the optic vesicle at age 10.5 dpc (Figure 1A-C). Optn transcripts were detectable at the forelimb buds as the second expression domain (Figure 1B,D). Examination of optic vesicle sections at age 10.5 dpc revealed a strong expression of Optn in the outer layer of the optic cup (future pigment layer of retina; Figure 2). At age 13.5 dpc, expression of Optn in the developing eye became even more prominent. The outer layer of the optic cup (future pigment layer of retina) showed a confined positive staining at a higher power view (Figure 3A,B). A slight expression signal was also present at the lens fibers and the anterior epithelium of the lens (Figure 3C). Similarly, the developing optic nerve and the axons of ganglion cells might show some expression of Optn mRNA (Figure 3D). However, difficulties of probe penetration into whole embryos, a common limiting factor for application of the whole-mount in situ hybridization assay, may have led to undetectable expression domains, particularly in tissues located more deeply and internally.
In our previous studies, we reported the association of mutations in human optineurin with adult-onset primary open-angle glaucoma . We further characterized the mouse ortholog of the human OPTN gene and showed a high degree of conservation between their gene and protein sequences . Expression analysis of optineurin gene in multiple adult mouse tissues by northern blotting revealed presence of Optn transcripts in various tissues . The optineurin protein in mouse is expressed in ocular tissues similar to its human and Macaca mulatta counterparts and it is associated intracellularly to vesicular structures near the nucleus [5,6]. The objective of this study was to further characterize ocular manifestation of Optn, and to profile its mRNA expression during eye development in the mouse embryo. Whole-mount in situ hybridization during days 10.5-13.5 of mouse embryos revealed very prominent expression in two specific domains, the eye and forelimb bud. By RT-PCR (reverse transcriptase PCR) the Optn transcript was detectable at 7.0 dpc in the mouse embryo , however, the small size and fragility of the embryos at ages of 8.5 and 9.0 dpc made it more difficult to observe the eye vesicle during our in situ hybridization evaluation. Similar to our findings, De Marco et al. , by in situ hybridization, also observed a prominent expression of Optn RNA in developing murine eyes at 10.5 dpc. Expression of Optn RNA in adult murine ocular tissues (i.e., cornea, lens, sclera, and remarkably in retina) have been observed by northern blot analysis [9,10]. Specific localization of Optn transcripts in ocular tissues of mouse embryos are in strong agreement with our previous findings and distribution of optineurin protein in lens fibers and the retinal layers of adult mouse eye . Our previous observation  has been further confirmed by other independent studies that showed expression of optineurin protein in the anterior segment, retina, and optic nerve by immunohistochemistry [9,10]. The restricted ocular expression throughout embryogenesis implies that Optn mRNA expression is developmentally regulated in a tissue-specific manner. Our findings further suggest that during embryogenesis, Optn may play a pivotal role in overall development of the eye. In adult murine eyes, the optineurin protein is highly expressed by retinal ganglion cells (RGCs) [5,9,10]. Furthermore, a transgenic mouse for the optineurin E50K mutation has recently been developed [11,12]. This study reported that overexpression of optineurin mutation promoted RGCs to go through apoptosis and thus leads to the cupping of the optic disc while the intraocular pressure remains within a normal range [11,12]. This observed phenotype is the most important resemblance to the reported clinical condition in glaucomatous neurodegeneration [13,14] and is compatible with the glaucomatous phenotype caused by the Optn-E50K mutation [4,15].
Future studies are needed to fully define the molecular mechanisms of Optn expression in the developing murine forelimb. Murine forelimb initiation precedes hindlimb development by roughly one gestational day at the age of 9.5 dpc. The presence of Optn transcripts only in the forelimb could be due to different timing of gene expression between the limbs or, alternatively, Optn could acts as a forelimb specific gene. A different transcriptome, as well as expression timing profiles, between the fore- and hindlimb has been reported . There is a remarkable conservation of gene transcripts between the two limb types, however, differential expression and utilization of commonly expressed genes, together with the small number of genes that are expressed in a specific limb type, may lead to limb-type-specific differentiation .
Nonisotopic whole-mount in situ hybridization of mRNA has greatly facilitated the precise three-dimensional localization of transcripts from genes whose expression is important during development. Due to the high sensitivity, expression profiling by PCR frequently delivers data that is difficult to prioritize. For example, PCR methods would detect expression of Optn and Cyp1b1 (Cytochrome P4501b1), a gene that is frequently mutated in patients with primary congenital glaucoma (PCG), in a wide range of tissues. Contrarily, as presented here and by our previous study  the whole mount in situ hybridization only identified the eye as a major expression domain in the developing embryo for both genes. This organ is significantly involved with the two different pathological phenotypes of glaucoma (PCG and POAG), both associated with the mutations in Cyp1b1 and Optn genes, respectively. Therefore, whole mount in situ hybridization delivers expression data that is biologically significant. The very restrictive and specific ocular expression of Optn as revealed in this study suggests that like the PCG-causative gene of Cyp1b1, the Optn may also play a significant role during the early stages of eye development. Interestingly the expression domains of Cyp1b1 and Optn do not overlap. Optn expression is limited to the outer layer of the optic cup while Cyp1b1 is expressed in the inner (neural) layer of the optic cup (future nervous layer of retina) . Specific expression profiles and involvements of both Cyp1b1 and Optn during early stages of eye development are compatible with their reported roles in two human phenotypes of primary congenital glaucoma and primary open angle glaucoma. Furthermore, comparable phenotypes as observed in the Cyp1b1-null mouse  and Optn-E50K transgenic animals [11,12] further corroborate the roles of these two genes in early stages of eye development and in human glaucoma.
This work was supported by NIH grant EY-014959.
1. Leske MC. The epidemiology of open-angle glaucoma: a review. Am J Epidemiol 1983; 118:166-91.
2. Congdon N, O'Colmain B, Klaver CC, Klein R, Munoz B, Friedman DS, Kempen J, Taylor HR, Mitchell P, Eye Diseases Prevalence Research Group. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 2004; 122:477-85.
3. Sarfarazi M, Child A, Stoilova D, Brice G, Desai T, Trifan OC, Poinoosawmy D, Crick RP. Localization of the fourth locus (GLC1E) for adult-onset primary open-angle glaucoma to the 10p15-p14 region. Am J Hum Genet 1998; 62:641-52.
4. Rezaie T, Child A, Hitchings R, Brice G, Miller L, Coca-Prados M, Heon E, Krupin T, Ritch R, Kreutzer D, Crick RP, Sarfarazi M. Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Science 2002; 295:1077-9.
5. Rezaie T, Sarfarazi M. Molecular cloning, genomic structure, and protein characterization of mouse optineurin. Genomics 2005; 85:131-8.
6. Rezaie T, Waitzman DM, Seeman JL, Kaufman PL, Sarfarazi M. Molecular cloning and expression profiling of optineurin in the rhesus monkey. Invest Ophthalmol Vis Sci 2005; 46:2404-10.
7. Xu Q, Wilkinson DG. In situ hybridization of mRNA with hapten labeled probes. In: Wilkinson DG, editor. In situ Hybridization: a practical approach. 2nd ed. Oxford University Press; 1998. p. 87-106.
8. Stoilov I, Rezaie T, Jansson I, Schenkman JB, Sarfarazi M. Expression of cytochrome P4501b1 (Cyp1b1) during early murine development. Mol Vis 2004; 10:629-36 <http://www.molvis.org/molvis/v10/a75/>.
9. De Marco N, Buono M, Troise F, Diez-Roux G. Optineurin increases cell survival and translocates to the nucleus in a Rab8-dependent manner upon an apoptotic stimulus. J Biol Chem 2006; 281:16147-56.
10. Kroeber M, Ohlmann A, Russell P, Tamm ER. Transgenic studies on the role of optineurin in the mouse eye. Exp Eye Res 2006; 82:1075-85.
11. Akahori M, Obazawa M, Noda S, Noda T, Tanaka y, Iwata T. Development and characterization of normal tension glaucoma mouse over expressing mutant of OPTN (E50K). ARVO Annual Meeting; 2005 May 1-5; Fort Lauderdale (FL).
12. Akahori M, Minami M, Obazawa M, Tomarev S, Nakaya N, Miyake Y, Iwata T. Characterization of normal tension glaucoma mouse over expressing mutant of OPTN (E50K). ARVO Annual Meeting; 2006 April 30-May 4; Fort Lauderdale (FL).
13. Quigley HA, Nickells RW, Kerrigan LA, Pease ME, Thibault DJ, Zack DJ. Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest Ophthalmol Vis Sci 1995; 36:774-86.
14. Farkas RH, Grosskreutz CL. Apoptosis, neuroprotection, and retinal ganglion cell death: an overview. Int Ophthalmol Clin 2001; 41:111-30.
15. Aung T, Rezaie T, Okada K, Viswanathan AC, Child AH, Brice G, Bhattacharya SS, Lehmann OJ, Sarfarazi M, Hitchings RA. Clinical features and course of patients with glaucoma with the E50K mutation in the optineurin gene. Invest Ophthalmol Vis Sci 2005; 46:2816-22.
16. Kimmel RA, Turnbull DH, Blanquet V, Wurst W, Loomis CA, Joyner AL. Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation. Genes Dev 2000; 14:1377-89.
17. Shou S, Scott V, Reed C, Hitzemann R, Stadler HS. Transcriptome analysis of the murine forelimb and hindlimb autopod. Dev Dyn 2005; 234:74-89.
18. Buters JT, Doehmer J, Gonzalez FJ. Cytochrome P450-null mice. Drug Metab Rev 1999; 31:437-47.

domain: medical


Chris Johnston is Director of Keysight’s Radar & Electronic Warfare Solutions, where he leads a highly experienced team of solution planners and business development managers. Chris began his career at Keysight (then Agilent Technologies) in 2000 working as a field engineer on strategic defense and component accounts. He moved into his current role in March 2021. Chris has a BS in Electrical Engineering from the University of Cincinnati, and he is an AOC member belonging to the Mile High Country Crows Chapter.
JED: What are some of the major EMS Operations (EMSO) trends that you are seeing and how are they driving the types of test equipment that Keysight is offering for the EW market?
Johnston: From a test perspective, we see EMS operational requirements mapped directly to test and evaluation and those requirements go well beyond the capabilities of a single spectrum analyzer, arbitrary waveform generator, or oscilloscope. Diminishing are the days of testing with a “box” used for one single type of test. It is a much more solution-oriented approach, which requires the integration and combination of many legacy and emerging test ideologies that drives our business today. Our government and industry customers require us to help to integrate complex test solutions that incorporate next-generation technology, while including importer tools and compatibility with legacy solutions, to not lose years of engineering work. This is an important requirement. Otherwise, we are placing the burden of integration on them, which slows down their core business – creating the protection and countermeasures systems and algorithms necessary to protect the warfighter.
It is the leverage of multiple traditional test assets, or their associated IP, collated to create a more comprehensive solution, which is now the norm. This includes the drive to develop multi-domain (frequency and time) measurement tools to address more complex test needs to test mixed RF and digital devices. Parallel to improving the hardware, there is high demand on the software modeling and simulation environment required to control – and replicate – both the simple and complex scenarios of an entire A2AD environment. Recognizing as the A2AD becomes more complex, we must challenge our R&D teams to provide more SWaP-C optimized test solutions, as well.
JED: As Keysight began to focus on the EMSO market, what types of software and hardware did you develop that enabled you to scale COTS test equipment into solutions that simulate large, complex EMS operating environments?
Johnston: Keysight has been focused on the EMSO market for decades. What has changed, as we all know, is the complexity of the threat environment due to the rapid advancement digital COTS technology, which can be exercised very fast and flexibly. I think it is the fact that Keysight touches every major technology market, and every major technology evolution worldwide, that puts us in a unique position to address EMSO. The same proprietary technology that went into our standard test products for semiconductor suppliers, telecommunications operators, advanced R&D centers and universities (the starting point of the A/D digital revolution) are what we leveraged into the products we use today for our EMSO solutions portfolio. This has allowed us to advance our solutions so rapidly to address the complexity EMSO faces today – and we are just getting started.
JED: How does your focus on EMSO testing and simulation fit your products and solutions for other Aerospace and Defense markets, such as spectrum monitoring and signal analysis, communications, radar, avionics, and space. How do you create synergies, both in terms of hardware and software products, across these markets?
Johnston: As I mentioned earlier, we can flex R&D investments for multiple market test needs into our EMSO solutions. Just this year, we had a defense customer mention a requirement in casual conversation about a test challenge their program office was presenting to them. Without going into details, we were able to quickly incorporate part of our wireless-market test capabilities into our overall EMSO solution and demonstrate it on the customer’s widget within three months. This was both a software and hardware integration, followed by the onsite demonstration hooked up to the device under test. We also do this for other parts of our A/D solutions portfolio, including Space, comms, radar and avionics, but the core test and measurement technology is at the heart of all our solutions. Keysight’s decades of engineering experience is utilized to bring to market industry-leading solution platforms that are used across multiple industries. One example is Keysight’s dedication to provide design and test solutions for electronically steered antennas, which are used in many different industries including wireless comms, signals intelligence and earth observation applications.
JED: What are some of the product areas where Keysight is focusing on new offerings for the EMSO and spectrum monitoring markets?
Johnston: As the environment becomes more congested and more contested, our test solutions must provide more capability at less cost and size than previous generations. Our business is like the warfighter in that we are SWaP-C driven. As the digital domain continues to be more flexible and adaptive, companies like Keysight need to provide analysis and insights faster – without human intervention. More emphasis on modeling and simulation will continue to grow using, for example, digital twins, but we will not lose sight of other requirements to transduce software into very high fidelity, metrology grade RF signals the warfighter can trust.


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Specialized ateliers, basic through advanced levels of pastry and confectionary craft making, plated and boutique style desserts, world delicacies and precise decorating techniques.
Intensive Culinary Course – Methods of Cooking
One of the first steps in learning how to cook is learning the proper cooking methods and
techniques including the various ways to cook. There are many to learn, and they each
cooking method has their advantages and disadvantages. You’ll begin to notice a trend
when it comes to applying cooking methods to various food items. There are some
methods that are basic, and some that are advanced cooking techniques. In this class you
will learn to use different ingredients like vegetables , eggs , meats and seafood

domain: hobby


SANFL clubs charged with salary cap breaches
SANFL clubs Port Adelaide and West Adelaide have been charged with breaching salary caps last season.
The league's Salary Cap Auditor has found the Bloods breached the cap by more than $38,000 and the Port Magpies were nearly $20,000 over.
Both clubs could face fines of $50,000 and other penalties.
They have two weeks to respond to the charges.
A statement from Port said accidental allocations and paperwork errors were only discovered at the end of the season.


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Apperley Bridge pupils take on Swedish national rugby team during tour (From Bradford Telegraph and Argus)
Get involved: send your pictures, video, news and views by texting TANEWS to 80360, or email
Apperley Bridge pupils take on Swedish national rugby team during tour
10:40am Monday 4th March 2013 in News
Rugby players from Sweden tried their skills against Yorkshire students during a match at Woodhouse Grove School.
The Swedish under-18s rugby squad played at the Apperley Bridge School during their tour of the county over February half term.
One of their two matches against the West Yorkshire U17s Development XV was held at Woodhouse Grove.
Pupils at the school James Exley, Lewis Brooke and Tom Fountain, who are studying for their A-levels, were selected for the West Yorkshire team playing against the national side on their own pitches.
Paul Fountain, chairman of West Yorkshire Player Development committee said “Everybody enjoyed the game on and off the pitch, with great crowds coming to watch. For me the tour encapsulated everything that is great about rugby – making new friends, respecting your opponent and, most importantly enjoying the experience.”


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vTv Therapeutics (VTVT) to Present New Small Molecule Drug Candidate Data as PD Treatment at Upcoming Conference
- Wall Street turns defensive on Trump's protectionist stance
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- McDonald's (MCD) Tops Q4 EPS by 3c
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vTv Therapeutics Inc. (Nasdaq: VTVT) announced that Dr. Bobby Thomas, Associate Professor at Medical College of Georgia, Georgia Regents University at Augusta, will present a poster at the Society for Neuroscience 2016 meeting in San Diego, featuring new pre-clinical data on a vTv small molecule drug candidate against Parkinson’s disease (PD).
vTv has identified novel non-electrophilic Nrf2/Bach1 modulators that can activate nuclear factor-E2 related factor (“Nrf2”) and inhibit Bach1 (the Antioxidant Response Element (“ARE”) transcriptional repressor) leading to potent activation of the Nrf2 pathway. The results from the laboratory of Dr. Thomas suggest (1) Bach1 may be a promising novel target for drug development against Parkinson's disease, and (2) vTv's compound, HPPE, may protect against nigrostriatal dopaminergic neurodegeneration by virtue of its ability to activate neuroprotective Nrf2/ARE genetic response in a preclinical mouse model of Parkinson's disease.
Based on recent findings, aberrant oxidative stress and inflammation play a key role in the pathogenesis of PD and preclinical studies suggest that activating the Nrf2/Bach1 pathway could have disease modifying effects on PD. Current pharmacological approaches targeting the Nrf2 pathway presents safety and tolerability issues as these pharmacophores contain reactive electrophilic groups.
Parkinson's disease is a progressive and debilitating neurodegenerative movement disorder characterized by marked nigrostriatal dopaminergic cell loss in the brain. No preventive therapy or cure is yet available for PD.
Dr. Thomas will be available to discuss the findings at the Society for Neuroscience 2016 meeting on Wednesday Nov. 16 from 1-5:00 pm at poster #19, Hall D-H at San Diego Convention Center.
About vTv Therapeutics
vTv Therapeutics Inc. is a clinical-stage biopharmaceutical company engaged in the discovery and development of orally administered small molecule drug candidates to fill significant unmet medical needs. vTv has a pipeline of clinical drug candidates led by programs for the treatment of Alzheimer’s disease and type 2 diabetes as well as treatment of inflammatory disorders and the prevention of muscle weakness.
The company's Alzheimer’s disease drug candidate, azeliragon, is a novel oral small molecule antagonist of the Receptor for Advance Glycation Endproducts (RAGE) with first-in-class potential.
The azeliragon development program has been granted Fast Track Designation and agreement on its Phase 3 protocol has been reached with FDA via a Special Protocol Assessment (SPA). Enrollment of part A of the Phase 3 STEADFAST study in patients with mild Alzheimer's disease was completed during the third quarter and topline data from this part of the study is anticipated to be reported in early 2018.
vTv is also pursuing the clinical development of TTP399, a novel liver selective Glucokinase Activator (GKA) with first-in-class potential for the treatment of type 2 diabetes. The company recently announced positive top line results from the six month phase 2b AGATA Study in subjects with type 2 diabetes.
vTv’s second diabetes drug candidate, TTP273, is an oral, small molecule GLP-1R agonist with best-in-class potential. The company reported the completion of enrollment of the three month Phase 2 LOGRA study in the third quarter with data readout expected at the end of 2016. The previous Phase 1b trial of TTP273 demonstrated robust effects on postprandial and fasting glucose. All doses of TTP273 were well tolerated with no serious adverse events or evidence of gastrointestinal side effects compared to placebo.
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domain: health


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For those who think manipulating the human body and its organs to create something resembling the undead belongs solely to the realm of Science Fiction, it might be time for a reevaluation of that assumption.
A remarkable breakthrough in the field of biology comes with the creation of a ‘modular body’—a seemingly living entity that isn’t quite alive. Biologist Cornelis Vlasman envisions a human body that functions in a manner similar to the LEGO blocks we grew up with. Consequently, Vlasman developed OSCAR, a living, organic system composed of his own cells combined with the capabilities of technology. OSCAR’s distinctive feature is its interchangeable system, reminiscent of LEGO blocks, that allows for the formation of specific configurations. Moreover, Vlasman demonstrates how his electric brain module connects to a lung module, enabling interaction between the two synthetic ‘organs.’ The process continues as he attaches additional modules, such as a kidney and limbs. A bloodstream and nerve signals course throughout the connectors of this modular body.
Though Vlasman notes that OSCAR is merely in its prototype stage, it is evident that the system manages to convert the human body from a closed system into an open-source one. This modification indicates the potential for a damaged organ to be readily replaced with a new module. Additionally, with the attachment of supplementary modules, the human body could be ‘upgraded,’ allowing adaptability to various situations. Nonetheless, more work lies ahead for Vlasman, as merely using cells is not enough to ensure the experiment’s success and readiness for practical application.

domain: design


These images were taken at the Winchester Arms Factory, which has stood just north of Yale since the late nineteenth century.
Is there a place for manual labor in higher education?
TNJ sits down with David Samuels.
A persistent advocate for the unsettled brings New Haven's refugees home.
The Quinnipiac River Fund asks people to re-imagine their waters.
A new college joins Yale on the New Haven Green this fall.
What can one Canadian's board game tell us about the US elections?
The New Journal is instituting a new fact-checking system.
Literary flings for an intern in the city.


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Being an expert in urban development condition of East Asia, Peilei Fan spent the first half of her Fulbright Cross-strait Studies grant in Taipei, Taiwan. She developed an urban development index and framework, and will continue her research in Shanghai, China. In the video, she also shared her observations and experiences on the education system and natural outings in Taiwan.
Dr. Peilei Fan is an associate professor of Urban & Regional Planning in the School of Planning, Design, and Construction at Michigan State University. She holds a joint research appointment at the Center for Global Change and Earth Observations. Dr. Fan’s research focuses on the urban environment, innovation and economic development. She is a Fulbright US Scholar of Cross-Strait Studies Program for 2017-2018 in Taipei and Shanghai.

domain: geography


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Deion Sanders' estranged wife arrested on assault charges
McKINNEY, Texas (AP) - Deion Sanders' estranged wife denies that she broke into his room in their Dallas-area home and attacked him in front of their children.
Pilar Sanders was arrested Monday on a misdemeanor domestic violence charge. She was released Tuesday and said she is innocent and that she's not being treated fairly because her husband is a Hall of Famer who played for the Dallas Cowboys.
Authorities haven't released details about the alleged attack. But Deion Sanders tweeted Monday that his children "just witnessed their mother and a friend jump me in my room."
Sanders filed for divorce in December. KTVT-TV reports that a judge ordered Pilar Sanders to stay away from the couple's home for 60 days.
The couple starred in an Oxygen network series, "Deion & Pilar: Prime Time Love."
Immediately after the alleged incident, Sanders sent out three tweets, including one that included a picture of himself and his kids apparently filling out a police report.
Pray for me and my kids now! They just witnessed their mother and a friend jump me in my room. She's going to jail n I'm pressing charges!— DeionSanders (@DeionSanders) April 23, 2012
That tweet and another one he sent out were later deleted.
ABC7's Justin Karp contributed to this report.

domain: law


Jul 11, 2013, 4:56 PM EST
When Chris Wondolowski scored a first-half hat-trick against Belize with “Wondowlowski” on the back of his jersey, Kei Kamara took notice.
So now, thanks to a wonderful image from Sporting KC kit manager Michael Flaherty, we see what Kamara’s got up his sleeve for their upcoming match against Toronto FC on Saturday.
Whether he’ll wear it or not, “Kamwara” will have new inspiration to drive him to grab his fifth MLS goal of the season, and possibly more.
Flaherty’s take: “Hey, it worked for Wondo.” We’ll certainly give you that.
Don’t forget, with his corrected jersey on for the second half, Wondolowski was shut out. Just sayin’
Sporting will host the East’s 9th place club with their eyes on the top spot in the conference.
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Some autos Have got a fuse which often can blow and retain the alternator from charging. Others will not charge if the alternator warning gentle bulb is burned out! On older Chrysler items (eighty's), and many newer vehicles of other producers, (2000+) the alternator is managed by the computer.
Factory bolts usually are not a bad source always, but whenever they have other electrical elements using them as a floor this can be a supply of sound. If you are not employing a new floor stage then you'll want to verify your manufacturing facility bolt fulfills the criteria earlier mentioned.
The difference between a steel defend and rubber sealing has got to do with optimum rpm. Supplied The ten.8k rpm max alternator pace when used in the sort 4 engine with 5400rpm rev limiter, double rubber seals will suffice but it surely's essential that the bearings be sealed since the inside the alternator receives extremely dusty, In particular among the slip ring and its bearing.
Besides the upper 15A peak output capacity, the alternator is physically unique in the 55A version:
The most beneficial price I have noticed with a rebuilt unit is $129 from PFI and there is no Main rate to pay for! I am not able to provide any feed-back on the quality until I see a unit myself but I believed I would mention it.
Flushing an RV h2o heater using a Camco flushing Software can stop problems with your drinking water tank and lengthen the daily life of your respective RV water heater. Anytime your RV h2o heater is flushed, it is a superb time to examine the anode rod and exchange if essential. Anode rods supply protection to your RV drinking water tanks from really hard h2o and minerals from the water and want to be replaced periodically.
DIODE: A "A method valve" for electricity. Diodes have lower resistance in a single direction, and infinite resistance in another.
The alternator is the principle Portion of the charging procedure. Not only does it cost the battery, but In addition it supplies electricity to the entire automobile if the motor is jogging. With no alternator, your automobile will die promptly.
How overrunning alternator pulleys fall short Overrunning alternator pulleys are unsuccessful by either locking up and failing to above operate properly, or by failing to lock up inside the push direction. For those who have belt challenges or sounds, Verify the alternator pulley.
Among the most prevalent challenges on an ageing alternator come up from worn out brushes. But a charging circuit blown fuse, a damaged fusible url, a failed diode while in the alternator's rectifier assembly, even a worn out bearing will have an affect on charging procedure operation.
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Substantial frequency alternators with the variable-reluctance style were being applied commercially to radio transmission inside the low-frequency radio bands. These were employed for transmission of Morse code and, experimentally, for transmission of voice and songs. In the Alexanderson alternator, both the field winding and armature winding are stationary, and present-day is induced in the armature by virtue in the modifying magnetic reluctance of your rotor (which has no windings or existing carrying parts).


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Cisco’s Routing business is showing slow growth
Cisco (CSCO) calls its router business Next Generation Network (or NGN) Routing. This business continues to show slow growth, and it grew by a year-over-year rate of 2% in fiscal 2Q15. The situation is even worse when we analyze the business’s growth in the previous quarters. As the chart below shows, before the last quarter, Cisco’s routing business’s year-over-year revenue growth was in negative territory.
During the latest earnings call, Cisco’s management mentioned that its new router products—such as CRS-X and NCS—showed strong growth in an otherwise weak router market.
Alcatel-Lucent is gaining share at Cisco’s expense
The overall router market is indeed struggling to grow. According to a report from Dell’Oro Group, the service provider core router market declined by a year-over-year rate of 8%, while the service provider edge router market was flat as of calendar 3Q14. The report also mentioned that Cisco, Alcatel-Lucent (ALU), Juniper (JNPR), and Huawei were the top four players in the service provider router market, with a combined market share of 94% as of calendar 3Q14. However, except for Alcatel-Lucent, all these players recorded negative year-over-year growth rates.
Alcatel-Lucent’s 7950 XRS core router has started to become popular. In October last year, CenturyLink (CTL), one of the largest telecom companies in the US, agreed to deploy Alcatel-Lucent’s 7950 XRS core router to support its growing broadband needs. In the previous part of the series, we also discussed how Alcatel-Lucent gained contracts with China’s (FXI) major telecom providers. Alcatel-Lucent’s growing market share certainly threatens Cisco.


text:
Besto Game團隊推出了《Idol Showdown》，一款由Hololive粉絲開發，採用回滾網路技術（Rollback）的Hololive格鬥遊戲。遊戲在Steam平台上以免費遊玩的形式推出，適用於PC，本作一開始共有八個角色可供選擇，未來還計劃免費推出至少三名新的戰鬥角色。
目前《Idol Showdown》的遊戲評價是1,291則的壓倒性好評，在 Steam 平台上獲得絕佳的迴響，甚至有人疾呼：「桐生会に栄光あれ 桐生会は不滅なり！」
This is a free unofficial fan-made project, made out of love for hololive, hololive fans, and the fighting game genre.
After 2 long years of hard work, the first complete fan-made hololive fighting game is here!
◆ Easy Controls
Pick up on this game’s easy-to-learn control scheme in no time to get straight into playing. Even hololive fans who are inexperienced with traditional fighting games can have fun!
◆ Rollback Netcode
Besto Games has been hard at work developing the game’s online rollback netcode to make the online experience as smooth as we can.
◆ An Immersive hololive Experience
Explore the vast world of hololive from our roster of iconic hololive talents, with moves inspired by their most memorable moments and personality traits. Fight across the virtual world in lovingly recreated hololive locations. Jam out to remixes of your favorite hololive original songs while raising idol hell.
◆ Fast 2D Combat
hololive talents are reimagined as core fighting game archetypes with a unique twist. Raise chaos in the battlefield with flashy attacks and high-octane action.
「 Idol Showdown」宣傳影片
點一下追蹤 IG 與吹著魔笛的浮士德粉絲團 🙏
↓追蹤 Facebook 專頁↓


text:
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text:
Here is a classic Quiche Florentine recipe that’s easy to prepare thanks to store-bought pie dough. Filled to the brim with eggs, cream, fresh spinach and Gruyere cheese, it’s the perfect light and savory meal to serve for breakfast, brunch, lunch, dinner or any time in between.
1 store-bought pie dough disk, or homemade
1 tbsp olive oil
½ yellow onion, finely diced
2 cups baby spinach
½ cup heavy cream
2 tsp Dijon mustard
½ tsp nutmeg
2 tsp minced rosemary
2 tsp thyme sprigs
½ tsp kosher salt
Cracked black pepper
1 cup grated gruyere cheese
Arugula, for topping/serving
- Blind bake the pie shell: Preheat the oven to 375 F. Unroll your pre-made (or homemade) pie dough disk into a 9-inch pie or tart pan. Trim or flute the edges of the pie dough so they don’t overhang. With a fork, prick the bottom of the pie dough all over to ventilate. Place a piece of parchment paper over the pie dough and add 1 cup of dried beans or raw rice on top. Bake for 20 minutes, or until the dough is slightly golden. Remove from oven and cool.
- Saute onions and spinach: While the dough is baking, begin the onion mixture. In a medium saute pan over medium-low heat, add the olive oil. Add diced onions and season with salt and cracked black pepper. Saute for 5-6 minutes, stirring occasionally, until they begin to brown and caramelize. Add spinach and stir together until the spinach has wilted, about 1-2 minutes. Remove from heat.
- Whisk the filling: In a medium bowl, whisk together eggs, heavy cream, Dijon mustard, nutmeg, rosemary, thyme, kosher salt and a few turns of cracked black pepper until smooth.
- Assemble the quiche: Evenly distribute the onion-spinach mixture into the bottom of the cooled pie crust and sprinkle the shredded gruyere on top. Pour in the egg mixture and spread into one even layer.
- Bake and cool: Bake for 30-35 minutes, or until the center is set and no longer jiggles. Let the quiche cool for 10-15 minutes. Serve warm or at room temperature, with fresh greens for topping.
Keywords: eggs, pie dough, spinach

domain: food


MEMORANDUM OF UNDERSTANDING
U.S. DEPARTMENT OF AGRICULTURE
NATURAL RESOURCES CONSERVATION SERVICE
TROUT UNLIMITED, INC.
This Memorandum of Understanding (MOU) is entered into and between the U.S.
Department of Agriculture (USDA), Natural Resources Conservation Service (NRCS)
and Trout Unlimited, Inc. (TU).
I. PRINCIPAL AUTHORITIES
This MOU is entered into under the following principal authorities:
• Soil Conservation and Domestic Allotment Act, as amended [Public Law 74-46, 49
Stat. 163, 16 U.S.C. 590 b-f].
• Commodity Credit Corporation Charter Act as amended [15 U.S.C. 714c].
• Food Security Act of 1985 as amended [16 U.S.C. 3841 et. seq.].
• Food, Agriculture, Conservation and Trade Act of 1990 [Public Law 101-624].
• Farm Security and Rural Investment Act of 2002 [Public Law 107-171].
NRCS provides planning, technical, and financial assistance for the conservation of
natural resources on private lands. Wetlands and aquatic habitats and the species
utilizing them are considered to be two of several key resource concerns by NRCS in
their ecosystem-based approach to conservation. Many aquatic species, including both
coldwater and warmwater fishes, have specific habitat requirements that must be met to
sustain their populations. USDA conservation programs such as the Conservation
Reserve Program (CRP), Conservation Reserve Enhancement Program (CREP),
Wetlands Reserve Program (WRP), Environmental Quality Incentives Program (EQIP),
and Wildlife Habitat Incentives Program (WHIP) help protect, restore, and enhance
essential components of aquatic habitats, including clean water, stable streambanks,
intact uplands and riparian areas, fish passage, instream, and floodplain geomorphology.
The mission of TU is to conserve, protect and restore North America’s trout and salmon
fisheries and their watersheds. TU accomplishes this mission on local, State, and
national levels with an extensive and dedicated volunteer network. TU’s national office,
based just outside of Washington, D.C., and its regional offices employ professionals
who testify before Congress, publish a quarterly magazine, intervene in federal legal
proceedings, and work with the organization’s 125,000 volunteers in 500 chapters
nationwide to keep them active and involved in conservation issues.
The purpose of this MOU is to provide a framework for cooperative activities between
NRCS and TU necessary to maintain and enhance wetland and aquatic habitats and
associated fish, and aquatic species. Such activities can include, but are not limited to
aquatic and riparian habitat improvement projects, fish passage projects, the provision of
technical assistance, delivery of information and educational materials, collaboration on
aquatic habitat and fisheries research, and the development of habitat improvement
A. NRCS and TU mutually agree:
1. That each and every provision of this MOU is subject to the laws and
regulations of the United States.
2. To attempt to identify and develop cooperative projects, including
project title, description, scope, objectives, costs, anticipated outputs
and period of performance for activities that advance aquatic habitat
3. To attempt to implement the most beneficial practices available for
aquatic and riparian habitat conservation by seeking out and
employing the latest technologies and practices, by forming
partnerships with other governmental and/or non-governmental
agencies, groups, and individuals to enter into innovative cooperative
programs for more large scale conservation projects, and by working
cooperatively to maximize the amount of federal funding that goes
towards aquatic and riparian habitat conservation.
4. That this MOU is neither a fiscal, nor funds obligating document. Any
endeavor by either party that involves the reimbursement, contribution
of funds, transfer of anything of value between the parties will be
handled in accordance with applicable laws, regulations, and
procedures. Such endeavors shall be outlined in separate agreements;
shall be made in writing by representatives of both parties; and will be
independently authorized by appropriate statutory authority. This
MOU does not provide such authority.
5. That either party may assume the responsibility for the design and
implementation of projects under this MOU if such projects are
completed subject to appropriate standards and specifications mutually
agreed to by NRCS and TU in the project specific cooperative
agreement, grant, task order, or contract.
6. To collectively review programs and activities associated with this
MOU to assess progress and to plan future program direction as
7. That nothing herein shall be construed as obligating NRCS to expend,
or as involving the United States in any contract or other obligation for
the future payment of money in excess of appropriations authorized by
law and administratively allocated for these projects by NRCS.
8. That nothing herein shall be construed as obligating TU to expend, or
as involving TU in any contract or other obligation for the future
payment of money in excess of budgeted and available funds allocated
for these projects by TU.
9. That each party agrees that it will be responsible for its own acts and
shall not be responsible for the acts of other parties and the results
thereof. Each party, therefore agrees, that it will assume all risk and
liability to itself, its agents or its employees, for any injury to persons
or property resulting in any manner from the conduct of its own
operations, and the operations of its agents or employees, under this
MOU, and for any loss, cost, damage, or expense resulting at any time
from failure to exercise proper precautions, of or by itself or its own
agents or its own employees, while occupying or visiting the projects
under and pursuant to this MOU. The Government’s liability shall be
governed by the provisions of the Federal Tort Claims Act (28 U.S.C.
10. That each party recognizes that the other party may work
independently and in cooperation with other entities in the completion
of the type of conservation activities applicable to this agreement.
B. NRCS agrees:
1. To provide training, as it deems necessary, to its staff on fish and
aquatic habitat conservation using as one of many technical sources
the current technical information provided by TU.
2. To utilize its public information program to inform private landowners
about aquatic and riparian habitat conservation practices and
programs, including when appropriate distribution of technical and
financial assistance information is available through TU.
3. To provide appropriate recognition of TU on all cooperative projects
conducted under this MOU.
4. To provide assistance for cooperative activities under this MOU
subject to project specific cooperative agreements, grants, task orders,
or contracts. Examples of activities that should receive assistance
include, but are not limited to, riparian buffer improvements and
planting of forest buffers, in-stream improvements such as stream
channel modifications and restorations, stream bank protection and
stabilization, fish passage projects, water conservation projects,
livestock fencing, education and outreach programs, and any other
projects that benefit aquatic and riparian habitats.
5. To provide assistance for implementing the use of innovative
technologies and projects which address the mutual goals of TU and
NRCS for aquatic and riparian habitat conservation.
C. TU agrees to:
1. Provide NRCS with information regarding the status of fish and other
aquatic species populations and stream, lake, and riparian habitat
2. To inform its members and the general public about aquatic and
riparian habitat conservation projects conducted cooperatively with
3. To inform its members and the general public about the conservation
programs offered by NRCS, and to encourage those entities to apply
for and undertake the practices necessary to become enrolled in those
4. To assist NRCS in the training of its personnel in aquatic and riparian
habitat conservation and management.
5. To provide assistance to NRCS for cooperative activities under this
MOU subject to project specific cooperative agreements, grants, task
orders, or contracts.
6. To provide appropriate recognition of NRCS, TU members, and the
general public on all cooperative projects conducted under this MOU.
This MOU is to define, in general terms, the basis on which the parties concerned will
cooperate, and as such, does not constitute a direct financial obligation for expenditures.
1. Howard Hankin (Technical)
National Aquatic Ecologist
P.O. Box 2890, Room 6150-S
Washington, DC 20013-2890
2. Kathryn Staley (Technical)
Wildlife Habitat Management Institute
Department of Fisheries and Wildlife
104 Nash Hall
Oregon State University
Corvallis, OR 97331
3. Diane E. Gelburd
Director, Ecological Sciences Division (Administrative)
P.O. Box 2890, Room 6158-S
Washington, DC 20013-2890
1. Joe McGurrin
1500 Wilson Boulevard, Suite 310
Arlington, VA 22209-2310
2. Chris Wood
Director of Watershed Programs
1500 Wilson Boulevard, Suite 310
Arlington, VA 22209-2310


text:
Cinema actor. He was born in Eskişehir in 1937. His real name is Fahrettin Cüreklibatur. His father is one of the veterans of Independence War, Hacı Yakup. He graduated from Eskişehir Atatürk High School and Istanbul University Faculty of Medicine (1961). He won a contest organized by a magazine and started his acting career with Gurbet Kuşları directed by Halit Refiğ (1964). Arkın started to play leading roles in a short time. He was the third actor in Turkish cinema to be remembered with the nickname “King” after Ayhan Işık and Yılmaz Güney. After 1980s he rather acted in adventure movies. He also worked as director in some movies aside from acting. He won the Best Actor Award with his movie İnsanlar Yaşadıkça, in 1969, with his movie Mağlup Edilemeyenler in Antalya Altın Portakal Film Festival in 1976; and with his movie Yaralı Kurt in Adana Altın Koza Film Festival in 1972. In 1999 he was granted life-time honorary award in Antalya Altın Portakal Film Festival.
Kaderin Mahkûmları (1964), Gözleri Ömre Bedel (1964), Sokakların Kanunu (1964), Sıkı Dur Geliyorum (1964), İstanbul Yankesici Kız (1964), Kıskanç Kadın (1966), Malkoçoğlu (1966), Karanlıklar Meleği (1966), (1968), Malkoçoğlu Kara Korsan (1968), Kader (1968), Acı İntikam (1968), Selahattin Eyyubi (1970), Oyun Bitti (1971), Adını Anmayacağım (1971), Küçük Sevgilim(1971), Battal Gazi'nin İntikamı (1972), Kara Murat Kara Şövalyeye Karşı (1975), Üç Kağıtçılar (1975), Kılıç Aslan (1975), Şafak Sökerken (1988), Dünyayı Kurtaran Adamın Oğlu (2006).

domain: artistic


text:
(David fled from King Saul’s renewed desire to kill him) and went to . Jonathan (who said) You shall not die! why should my father hide this thing from me? It is not so!" 1 Samuel 20:1,2
The prudence of the best heads is often defeated by tenderness of the best hearts.
Henry Fielding (1707 - 1754) English novelist
(David persuaded Jonathan of the possibility that his father, King Saul was trying to kill him and said) . deal kindly with your servant, for you have brought your servant into a covenant of the Lord with you. 1 Samuel 20:3-8
Friendship, of itself a holy tie, Is made more sacred by adversity. John Dryden (1631–1700)
.Jonathan said to David: When I have sounded out my father sometime tomorrow. and indeed there is good toward (you), and I . (will) tell you . But if it pleases my father to do you evil, then I will report it to you and send you away, that you may go in safety. 1 Samuel 20:12-13a
A faithful friend is a strong defense; And he that hath found him hath found a treasure.” Louisa May Alcott quotes (American Author known for her children's books, especially the classic Little Women. 1832-1888)
(Jonathan to David) . the Lord be with you as He has been with my father.. (honor my life and) not cut off your kindness from my house (family) forever.. 1 Samuel 20:13b-15 (Jonathan, heir apparent to the throne, knew David would become king)
Acceptthe place (God in His providence) has found for you, the society of your contemporaries, the connection of events. Ralph Waldo Emerson
So Jonathan made a covenant with the house (present and future family) of David. 1 Samuel 20:16
True friendship extends to families and spans generations.
'Bible verse and quote' Copyright 2020 © Jan Couns. 'Bible verse and quote' articles may be reproduced in whole under the following provisions: 1) A proper credit must be given to the author at the end of each story, along with their complete bio and a link to https://www.liveasif.org/ 2) 'Bible verse and quote' content may not be arranged or "mirrored" as a competitive online service.
"Point of Reference" from

domain: literature


text:
30 Martz Road, Sykesville, MD 21784, Phone # 410-795-5165
Hours: March 1st thru November 30th - 7 am until sunset (exact time posted at gatehouse) 7 days a week.
Private Boats may be launched for a fee of $8 per boat. Season Passes are available for $50 per boat.
Private boats MUST be off the lake 30 minutes prior to sunset. Exact times are posted at Gatehouse, Boathouse and Boat Ramps. See Section on Boat Rentals for Boathouse Hours of Operation.
December 1st thru February 28th - 8 am - 4 pm Monday thru Friday, closed weekends and holidays.
NO BOATING - This includes launching of Private Boats.
Natural, educational and recreational opportunities abound at Piney Run Park, Carroll County Maryland's
oldest developed park. The park was opened in 1974, featuring a 300 acre lake as its centerpiece and
provides multiple recreational activities such as fishing,
boating, boat rentals and
park sponsored fishing tournaments. The lake is surrounded by 550
acres of fields, forest and open spaces which contain over 5 miles of
hiking trails, as well as tennis courts, playgrounds, climbing rock,
picnic tables and comfort stations. The Piney Run Nature Center,
Park Office and six pavilions,
which are available to rent during our open season, are all located near the
main entrance which is accessed off of White Rock Road.
Piney Run Park Video Tour


The Second World War saw the involvement of many superpowers, and the prolonged fighting forced the majority to make much-needed advancements to their weaponry and equipment. Among the more notable was the night vision scope, which allowed the United States to turn the tide of the Battle of Okinawa.
Nighttime combat was a completely different beast
Throughout World War II, military forces knew they could garner a significant advantage if they attacked the enemy at night, given the lack of visibility. However, this was easier said than done, and some forces were better at it than others.
The Soviet Union, for example, had the “Night Witches.” Officially designated the 588th Night Bomber Regiment (later renamed the 46th Guards Night Bomber Aviation Regiment), they flew nighttime bombing missions against German targets, with around 261 women performing an estimated 23,672 combat sorties.
Another example was the Luftwaffe, which used the darkness of night to conduct offensives against the Allies. A number of their pilots became aces during this time, the most notable being Heinz-Wolfgang Schnaufer. As well, the most effective aircraft to fly during these missions proved to be the Heinkel He 219.
The Japanese excelled at night fighting
Out of all the military forces that fought in WWII, the Japanese were by far the most adept at night fighting. This was largely due to fears over conflict with the Soviet Union, which had a far superior force, in terms of numbers and available equipment. With a desire to ensure the odds were in their favor, the Imperial Japanese Army (IJA) began training troops on performing covert and nighttime attacks.
By the time they properly entered the fight in the Pacific Theater, the Japanese were so proficient that they were able to conduct effective strikes against the Allies, not only defeating them, but also striking fear into those they were fighting. The US military, in particular, wanted to figure out a way to fight back against the nighttime attacks as, while they lessened as losses began to mount, they still proved bothersome.
The way the American forces planned to do this was via technology. As the war drew on, officials stateside began to work on a new type of tool: the night vision scope.
Developing night vision scopes
The Wehrmacht was the first to introduce night-vision technology during the Second World War, with the first devices being developed in 1939. By the middle of the conflict, the Germans had moved on to testing infrared devices, which were used by Panther tank crews on both the Western and Eastern fronts.
The StG 44 was also equipped with Zielgerät 1229 Vampir (ZG 1229), an infrared device that was primarily used by those who were stationed on the Eastern Front. Given how rudimentary the technology was at the time, the ZG 1229 wasn’t all that easy to maneuver on the battlefield, with it weighing 33 pounds between the device itself and its battery pack.
The Americans also hoped to use night vision technology to help troops. The initial devices were officially known as the M1 and M3, but the majority of soldiers referred to them as “snipercopes” and “Snooperscopes.” They attached to M1 carbines.
Night vision scopes and the Battle of Okinawa
Occurring over the span of just under three months, the Battle of Okinawa saw the Japanese go head-to-head with the Americans, who were supported by the Canadians, New Zealand and the Australians. With the Allies close to winning the Second World War, the Imperial Japanese Army was becoming increasingly desperate, and nothing showed this more than the methods they used.
The battle saw an increased use of kamikaze attacks, with an estimated 1,200 aircraft used in seven major strikes between April 1 and May 25, 1945. On top of this, the IJA pressed nearly 1,800 school-aged children into service. Boys formed the Iron and Blood Imperial Corps, while girls were turned into nurses.
Against an opponent on Okinawa who had nothing to lose, the Americans needed an edge, and the night vision scope gave them just that. Approximately 200 were handed out to those fighting on the island, with 30 percent of Japanese casualties at the hands of small arms fire in the first week losing their lives to T3 Carbines equipped with the devices.
Night vision technology has advanced a lot
Following the Battle of Okinawa and the conclusion of the Second World War, the night vision scope was further developed and used, most notably in Korea and Vietnam. More advancements have followed, with noise-canceling effects, panoramic vision and the use of thermal imaging all becoming standard.
Today, night vision technology is regularly employed by the US and other countries, most notably those under NATO. It’ll be interesting to see just where these devices go – and how clear an image they’ll one day be able to produce.


text:
Showing results by narrator "John Lindsey Walker"
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How to Overcome Depression
- Get to Know the Symptoms and Learn the Right Treatment of Depression
- By: Manfred Werling eBooks
- Narrated by: John Lindsey Walker
- Length: 26 mins
Depression is more than a bad mood. In this book, we are going to look at depression to help you understand how to take care of it. Your friends and family need you. Regain your happiness and live the life you deserve.
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domain: library


Jude Patients CMT's Disaster Relief Concert, Music Builds, touched viewers' hearts Thursday night. The show began with images of devastated southern urban centers. Hank Williams Jr. as well as the Blind Boys of Alabama performed the gospel song, "I Saw the light. " The event was hosted by comedian Ron White, HLN's Robin Meade, and ESPN's Erin Andrews. They discussed the powerful storms that ravished sixteen states. 9 Nufactured. M. (TNT) THE CLOSER Season 6 sees after a hiatus to search out Brenda (Kyra Sedgwick) investigating the ambush of without doubt one of her colleagues, who Lady Antebellum concert already been accused of witness tampering. Mary McDonnell guest stars as Capt. Sharon Raydor. More information about Date For Lady Antebellum Summer Plays Tour Ticket Liquidator In Tampa Fl.
Then wrapping inside main stage will be another Americanidol star, Carrie Underwood. Country Music Television, aka CMT, has been around in operation since 1983 like a cable routine. The network presents awards annually to the biggest and brightest stars over the past year in country music video. This year's big nominees for CMT Awards include Carey Underwood, Faith Hill, Miranda Lambert, Blake Shelton, Jason Aldean and Luke Bryan for single artists in male and female categories. In group categories the nominees include names like Lady Antebellum concert, Little Big Town, Zac Brown Band, The Band Perry and Rascal Flatts. Paisley and Underwood were both nominated this year for Men and women Vocalist of the season. Blake Shelton and fiancee' Miranda Lambert were 2010 winners in those categories. Some grand cherokee the duo of new tunes she played off her forthcoming album. She teased us with the fact that the record company wouldn't let her disclose the title of first single - but if I was a betting gal, I'd say "Slow Me Down," end up being it. It is a Lady Antebellum concert rocking tune with a reliable melody and super catchy hook. The other new tune "Put My Heart Down," was also catchy and simple to listen to.
If you are looking for Ticketsnow Lady Antebellum Summer Plays Tour Schedule 2018 In Wheatland Ca, sports tickets and theater seats at the best prices click here.


text:
Senator Lugar releases report entitled “Fraud and Abuse of Global Fund Investments at Risk Without Greater Transparency”
Senator Richard Lugar (R-IN), Ranking Member of the Senate Committee on Foreign Relations, released a minority staff report entitled, “Fraud and Abuse of Global Fund Investments at Risk Without Greater Transparency”. The report provides an historical overview of U.S. involvement with the Global Fund to Fight AIDS, Tuberculosis and Malaria though the President’s Emergency Plan for AIDS Relief (PEPFAR) and provides recommendations for improvement to both the U.S. government and the Global Fund.
Access the full report here. (PDF)
Read Senator Lugar’s press release about the report here.


text:
NEW ORLEANS (WVUE) - A St. Bernard Parish correctional officer charged with violating the civil rights of an inmate that resulted in her death, suffered a self-inflicted gunshot wound, according to Sheriff James Pohlmann.
Andre Dominick was taken to an area hospital on Thursday, the sheriff said. His condition is unknown.
Dominick and three others are accused of knowing that inmate Nimali Henry had serious medical needs and failed to provide her with necessary medical attention.
She died in April 2014.
The trial for the defendants started this week.
An investigation into the self-inflicted gunshot is ongoing.