text:
Official Event Layouts
There are no official event layouts available for this course.
Great for what it is - a nice, clean, pitch and putt course. The grass is always mowed, and easy to follow. It's short and sweet, and close to home.
Cons: No tees; no baskets, just 6x6 posts.
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domain: sports


text:
Background: The schizophrenia-associated BRD1 gene encodes a transcriptional regulator whose comprehensive chromatin interactome is enriched with schizophrenia risk genes. However, the biology underlying the disease association of BRD1 remains speculative.
Methods: This study assessed the transcriptional drive of a schizophrenia-associated BRD1 risk variant in vitro. Accordingly, to examine the effects of reduced Brd1 expression, we generated a genetically modified Brd1+/- mouse and subjected it to behavioral, electrophysiological, molecular, and integrative genomic analyses with focus on schizophrenia-relevant parameters.
Results: Brd1+/- mice displayed cerebral histone H3K14 hypoacetylation and a broad range of behavioral changes with translational relevance to schizophrenia. These behaviors were accompanied by striatal dopamine/serotonin abnormalities and cortical excitation-inhibition imbalances involving loss of parvalbumin immunoreactive interneurons. RNA-sequencing analyses of cortical and striatal micropunches from Brd1+/- and wild-type mice revealed differential expression of genes enriched for schizophrenia risk, including several schizophrenia genome-wide association study risk genes (e.g., calcium channel subunits [Cacna1c and Cacnb2], cholinergic muscarinic receptor 4 [Chrm4)], dopamine receptor D2 [Drd2], and transcription factor 4 [Tcf4]). Integrative analyses further found differentially expressed genes to cluster in functional networks and canonical pathways associated with mental illness and molecular signaling processes (e.g., glutamatergic, monoaminergic, calcium, cyclic adenosine monophosphate [cAMP], dopamine- and cAMP-regulated neuronal phosphoprotein 32 kDa [DARPP-32], and cAMP responsive element binding protein signaling [CREB]).
Conclusions: Our study bridges the gap between genetic association and pathogenic effects and yields novel insights into the unfolding molecular changes in the brain of a new schizophrenia model that incorporates genetic risk at three levels: allelic, chromatin interactomic, and brain transcriptomic.
Keywords: BRD1; Behavior; Cyclic AMP response element-binding protein (CREB); DARPP-32 signaling; Electrophysiology; Knockout mouse; Monoaminergic neurotransmission; RNAseq; Schizophrenia.
Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

domain: literature


India vs New Zealand 2019: DRS Controversy leads Daryl Mitchell dismissal
Updated: Aug 20, 2019
Daryl Mitchell's controversial lbw decision sparks new debate on DRS
Playing only 2nd T20I of his career, Daryl Mitchell, New Zealand all-rounder, featured in one of the all-time DRS controversies. Baffled with the third umpire's shocking decision, Daryl Mitchell had no other option than walk back to the hut. Not the technology or rules, Shaun Haig was at the receiving end for the decision.
As it Happened
India seeking revenge for the heavy drubbing at Wellington the other day were asked to bowl first in the 2nd T20Is as New Zeland won the toss at Auckland. Shorter boundaries and flatness of the deck at Auckland have always enticed batsmen. It has always been a happy hunting ground for batsmen or in other words, a batting paradise.
Batting first, New Zealand couldn't get off a flying start as it did in the first T20Is and ended up losing two quick wickets for just 41 runs under six overs. The drama took place on the final ball of the 6th over when Daryl Mitchell, facing his second ball of the innings, was trapped in front of the wickets by Krunal Pandya. What was supposed to be a plumb lbw from the naked eye, turned out even more controversial than it appears.
Soon after the on-field umpire showed his index finger, Daryl Mitchell knew he had edged it, upfront he referred the decision to the third umpire. During replay, Hotspot suggested a clear inside edge, however, after several set of replays TV umpire for more clarification moved on to the Snickometer which didn't show any spike when the ball passed. Based on the ball-tracking or Hawk-Eye where it ticked all three 'reds', Daryl Mitchell was declared out.
Shaun Haig, the TV umpire according to rule couldn't find enough evidence to overturn the on-field umpire's original decision. He potentially preferred Snicko over Hotspot. The mark showed on the bat in Hotspot may be a result of bat hitting the pad first. So, inconclusive evidence forced him to press the 'OUT' button.
The rule says,"If despite the available technology, the third umpire is unable to decide with a high degree of confidence whether the original on-field decision should be changed, then he/she shall report that the replays are ‘inconclusive’, and that the on-field decision shall stand. The third umpire shall not give answers conveying likelihoods or probabilities."
Skipper Kane Williamson threw his hands in the air and let the umpire know the dismay. But, umpire's hands were tied as they have already declared him out. The only way to reverse the decision, if Rohit Sharma let the batsman play. However, MS Dhoni, Rohit Sharma, Kane Williamson, and Daryl Mitchell had a small conversation in the middle, but it didn't yield any significant results.
Even Harsha Bhogle didn't see in favour of the umpire's decision. One of the leading commentators on-air said, "This is a horror mistake from Shaun Haig."
There have been several DRS faults in the past, and there will be in the future but despite having the technology in hand why the players have to pay for umpire's howlers.


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text:
Easier than I thought!
First time booked a cruise on-line - did it on a weekend day so the Live Chat helped to answer my questions quickly and easily when I was a little uncertain. The questions I had were about picking the cabins that were available (could say at top if the available cabins are marked or the unavailable cabins are marked on the map - yes unavailable cabins where not listed but when you are a bit anxious having things more clearly labelled could be good), if the discount mentioned was already applied (it was) and I also asked how I pick the option of bonus to take (1 of 4 as I booked an inside cabin) as it didn't come up within the booking process (crusie guru will contact me or I can email them - got email from Live Chat but will wait for them to contact me). I am very happy with my cruise - price, reduced deposits, deals/extras, cabin position and the ease I could do it for myself and that it was an australian website and I didn't have to worry about prices being in USD. I will definately book again online especially now I know the info above.
Great customer service very knowledgeable consultants
Recently booked another cruise through Cruise Guru they are very efficient and helpful. We booked late this time but our consultant took the time to find the best of the cabins left that was within our budget.
Best Consultant ever!!!!
My consultant was Helen and she was marvellous. Took care of everything in a most professional manner, was very obliging and couldn't do enough for me. Would highly recommend her.
Exceptional service & fantastic deals
We have booked several cruises with cruise Guru , who have always given great deals , better than going direct through the cruise liner.
My most recent booking they helped promptly with the enquiry I had and again gave me a great deal with a great deposit option.
Great efficient service!
Excellent offers with very efficient service and helpful staff, both on the phone and by email. Love the flexibility of payments for cruises. Navigating the check-in section was easy too.
Easy to use website
We always find Cruise Gurus website easy to use. We find their prices better than other online agents & love the $10deposits! Staff are pleasant to deal with and always very helpful. We book all our cruises through them now! Very easy process to book & also to cancel.
Very good service and advice
I called to find out if there was a cruise going to our destination of choice. I received an instant response with full details including shore excursions and cabin options with pricing. The deposit was explained as well as when the full fare would be due for payment. Special offers and the benefits of taking specific classes of cabin were also explained. Shortly after my wife and I discussed the suggestions we booked.. Easy as that. Very happy
Cruise Guru Operators Seem to Understand
I was not totally happy with Cruise Guru when I first booked with them.As it turned out my wife suffered a stroke & we had to cancel the cruise only weeks prior to departure. Cruise Guru were most helpful in arranging the cancellation documents required for the travel insurance claim & subsequently I have booked to undertake our cruise 8 months later when the doctors tell us that my wife should be o.k. to travel again. Cruise guru have been most helpful in finding us a cabin at a late stage when the ship was almost fully booked.
Such an enjoyable on line booking experience.
Booked Holland American cruise on line with absolutely no problems. All information required on Cruise Guru website. Follow up information and communications excellent. A wonderful experience for first time booker on line at 81years of age.
Booking with Cruise Guru.
Looking forward to my upcoming cruise to New Zealand.This is my second booking with Cruise Guru and it's been trouble free.I have yet to encounter any problems. If I have any I am confident they will be dealt with professionally.
Dedicated service and attention. Best of any travel agent I have had
Have been very impressed with the speed of communications and the willingness to immediately to any request.. Yes, Very much so. The untiring efforts to fulfil my every wish were very much appreciated.
Prices always appear to be equal or better than competitors Yes
Alaska, Russia and Japan adventure.
As an aged person I was having trouble booking on line so I rang to find out where I was going wrong and the young lady who answered not only helped me but did the booking for me on the phone.
I booked a 35 day cruise from from USA to Japan and my wife and I had a fantastic holiday on the Maasdam.
I booked with a lovely and helpful agent, Zainab, she was extremely helpful and made booking easy and there were no extra fees. I would definitely recommend Cruise Guru to my friends.
Booking a Cruise
Booked a cruise for September 2020
Booking was made easy by helpful booking agents (Helen) and one other.
Able to change cabin without any fuss, a pleasant surprise. and will book flights and accommodation as well later in the year.
Not used you before but found you answered my queries quickly also cruise confirmed on cruise company website same day.All in all you saved me $150 by booking with you,will use again....
Lovely consultant - very helpful.
Easy booking process. But since I booked, the link to follow to finalise details has been constantly broken.
Looking forward to doing this cruise without cyclone Gita chasing us!
Thanks Nora for your help during the booking process. 10/10
Cruise Guru do make dreams come true.
Booked many cruises with Cruise Guru and never encountered any problems. Cruise website is one of the best. Tried others but don't offer what Cruise Guru does. So easy to navigate site with all updated detailed information required. The ability to browse so many cruises while choosing your exact cruise date and destination is a dream. Plus the choice of your cabin from displayed deck plans with instant confirmation is an added bonus. Changing or cancelling a reservation is hassle free without charge. Pleasant and experienced staff are a treat to deal with by website or phone. Will be enjoying many more cruises thanks to Cruise Guru and staff.
No additional fees where charged with our booking with Cruise Guru.
We booked various cruises with Cruise Guru over the last year.
We have cancelled and changed some bookings with which was very easy.
so easy and a good experience.,
no additional fees all expectations were met booking our island cruise.so easy to select our cabin from the choices offered.we have booked with cruise guru before and we pleased with that experience and so here we are again.
Easy Fast Convenient
Finding the cruise, checking the details and booking was intuitive, one step followed the other and booking was made within minutes of finding the cruise we wanted. There is a comprehensive variety of the cruises on offer and filtering is incredibly easy.
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domain: travel


text:
Today, a telephone conversation took place between President of Turkmenistan Serdar Berdimuhamedov and President of the Russian Federation Vladimir Putin.
Expressing satisfaction with the opportunity to discuss topical issues of cooperation in a personal conversation, the head of the Turkmen state first of all congratulated his colleague and in his face all the friendly people of Russia on the significant anniversary - the 30th anniversary of the establishment of diplomatic relations between Turkmenistan and the Russian Federation.
Noting with satisfaction that over the years a multifaceted interstate dialogue based on the principles of sincere friendship, trust and good neighborliness has been successfully developing in the widest range of areas, President Serdar Berdimuhamedov expressed great gratitude to the Russian leader for his personal attention and all-round support, which play a special role in achieving great success in Turkmen-Russian relations.
During a telephone conversation, the interlocutors noted with satisfaction the positive dynamics in the development of relations in trade, economic, energy, cultural, humanitarian and other fields.
Emphasizing the importance of the planned visit to Ashgabat of the Government Delegation of the Russian Federation headed by Deputy Prime Minister A.Overchuk, President Serdar Berdimuhamedov expressed confidence that the upcoming exchange of views would serve to identify new areas of partnership and give an additional impetus to strengthening mutually beneficial cooperation, noting in this regard the special role of the Intergovernmental Turkmen-Russian commission for economic cooperation.
Expressing satisfaction with the active position of the Russian side in further strengthening productive ties between our countries, the head of state confirmed the interest of Turkmenistan in strengthening and building up partnership with the Russian Federation, with which good traditions of friendship and constructive cooperation have historically developed.
At the end of the telephone conversation, Presidents Serdar Berdimuhamedov and Vladimir Putin once again exchanged mutual good wishes for well-being and further prosperity for the friendly peoples of Turkmenistan and Russia.
Source: Turkmenistan State News Agency-TDH

domain: economics


Skills! Bayern star Douglas Costa pulled off an amazing elastico last night (Video)
German Bundesliga champions Bayern Munich played a barren draw away at Frankfurt last night in the Bundesliga as they could not continue their 100% record in the league.
During the match, Bayern Munich attacker Douglas Costa was closed down by two Frankfurt players on the left wing but the Brazilian amazingly beat both with a beautiful piece of skill.
What a player!


By Michelle DeMartino and Caroline Fiske
As Black History Month 2017 at Marist ends, mostly low attendance at the month’s events and the quiet struggles minorities still face in their college lives remaining unknown prove that the only evidence of remembering what was learned or taken away from February is what is changed going forward.
Marist celebrated Black History Month with a total of ten events by the end of February, including a CBS Sports Host interview, a slam poet and an Origins of Hip Hop event. While attendance was high in some and very low in others, a hard question followed: what measures success of the month? Is it attendance numbers?
CBS Sports Host James Brown and Special Producer for CBS News Alvin Patrick ’86 drew sports broadcasting majors and fans, from Marist College to the Hudson Valley. With most of the Nelly Goletti filled, slam poet Kyla Lacey, however, struggled with attendance, when she could only draw 25 people. Origins of Hip Hop event speaker Dr. Steve Peraza found himself only speaking to 21 people, taking place on the last few days of the month.
Is it what is changed going forward?
When the beginning of the month started, students were asked by Accepting Races and Creating Opportunities (ARCO) Club President Ted Dolce the first word they think of when they hear “Black History”, using Snapchat. Some that were spoken included strength, courage and power.
Sara Nowlin, a communication professor, talks about how minorities have to show these words every day. She describes how strides in inclusion still need to be made.
“How are we making the community and the campus more welcome? We can have people at campus, but if they don’t feel included… they leave or don’t graduate.”
She also explained that she finds that minorities frequently have to speak for their whole race, using the common quote: “Well let’s here from so and so.”
Tying in her statements, she pointed out that it’s a college student’s life and experience. The microaggressions and harassment that minorities are faced with is what is allowing the emboldening of the oppressed and underrepresented feelings from them.
What can be changed going forward?
Look up instead of look down. Look up at the historically important black figures in the Student Center from the past, present and future, where the future is being shown with pictures and aspirations of some of Marist College’s black students. Although Black History Month is over, the significance of showing strength, courage and power should always stay.


text:
All images used on map should be first uploaded to Image Library. It can be done through Image Library View.
Image Library View¶
There is possible to upload, delete and update images. They can be organized by different categories. View can be zoomed in or zoomed out(library zoom is saved).
- Images on map are displayed full size.
- Size of images predefined by NetXMS is 48x48

domain: geography


text:
Bangladesh’s High Court on Monday rejected a 28-year-old petition calling for the removal of a constitutional provision recognising Islam as the official religion of the Muslim-majority South Asian nation.
The court ruled that the petitioning organisation, the Committee against Autocracy and Communalism, did not have the right to be heard in the court.
Justice Quazi Reza-Ul Hoque, one of the three judges sitting on the bench, said that the court found that “the petitioner does not have locus standi and that is why the petition will be summarily rejected”.
The organisation’s lawyer, Subrata Chowdhury, said that he was “100 percent disappointed” with the decision.
“Without a hearing and without giving us any chance to present our argument on the point of locus standi, the court dismissed the case,” he said.

domain: politics


text:
May is our anniversary month, and we love to celebrate! This is our 3rd annual Faerie Travelogue, where we’ve documented our anniversary adventures. We love to share our playfulness. Catch a glimpse of our recent journey to the Kennebunks!
Our objective was to have fun, and we felt like doing some walking. Drawn to the ocean, we started off in a lovely little historic village. We felt like kids as we set out on our journey!
Allowing the magic to enter our souls, we followed where it led us. First we entered an amazing spinning forest. The wind was playful and kept everything in motion.
We met some curious beings there. This fellow gazed out his window at us, still sporting his winter garb.
These two pups were ready for summer, all decked out in their finery!
And we saw a school in session, though not in the water…
After some meandering, we decided that we needed to fuel up.
So we headed for a treat – ice cream!
After our faerie senses were abuzz, we looked for some fae places to explore. Beyond an invisible fence (which, strangely, we could see just fine)…
…there was a path. Its mystery and beauty drew us forward.
Tucked away, we found a cool temple made of stone.
BlackLion felt right at home peeking about. He pounced Starcat playfully!
In a bush of bright pink flowers, we bee-friended some honey makers.
A wolf friend kept watch over the path as it wove through the woods along the river.
And we encountered many faerie communities, both large…
After weaving through the woods for miles, we came upon a stone pathway…
…which led to the beach!
So we took a little break while BlackLion contemplated the ocean view.
We rested our tired feet and stretched our toes.
When we started to head back, we encountered a winding path with a snail friend still hiking her way along the beach.
Soon, we wound our own way back inland
And saw a strange sign
“Carnivorous Whelks?” Starcat exclaimed. She was very glad to find a way to avoid having her toes munched.
Around a bend, we came upon another portal…
…looked inside, and found more Love! We are blessed with lots of it!
On our path back to town, we took the high ground (remembering that those carnivorous whelks were still about)…
…and walked off into the sunset.
We ended our adventure with a lovely anniversary dinner very appropriate to our time at the seaside. We had seaweed salad, spring rolls, and sushi. We don’t eat fish but we love seaweed-wrapped rice and veggies dipped into wasabi-laden soy sauce. Wasabi is our favorite…yum!
We are excited about where our joyful adventures will take us next!


text:
Washington University in St. Louis has suspended indefinitely all activities of its men’s soccer team following allegations that team members made degrading and sexually explicit comments about members of the women's soccer team.
The university says it is conducting an investigation into the allegations, which were brought to the attention of administrators by members of the women's team.
"While the investigation is underway, the university has informed the men’s soccer team that, effective immediately and until further notice, it will be prohibited from participating in team activities of any nature," the school says in a news release. "This is merely a preliminary action; subsequent actions may be taken, depending on the outcome of the investigation."
The allegations leveled by the women’s team refer to degrading and sexually explicit comments being written about them in 2015 by members of the men’s team in an online document, and other inappropriate behavior that perpetuates a culture of disrespect toward women.
“We are saddened and deeply troubled by these allegations and are taking them very seriously,” says Lori S. White, vice chancellor for student affairs. “Let me be clear: There is absolutely no place at Washington University for sexism, discrimination or harassment of any kind. This alleged behavior flies in the face of the university’s core values of community support, diversity and inclusion, and we are firmly committed to conducting a timely and thorough investigation to address this matter.”
Earlier this month, Washington University's women's soccer team defeated Messiah College and won the 2016 NCAA Division III National Championship.

domain: law


text:
Did you mean: (endoderm)?
- Intra-vaginal testosterone improves sexual satisfaction and vaginal symptoms associated with aromatase inhibitors. [Journal Article]
- JCJ Clin Endocrinol Metab 2018 Sep 14
- CONCLUSIONS: IVT significantly improved sexual satisfaction and reduced dyspareunia in postmenopausal women on AI therapy. The low reporting of UI amongst women on AI therapy merits further investigation.
- Ejaculation effect on blood testosterone and prostatic pulsed-wave Doppler ultrasound in dogs. [Journal Article]
- RDReprod Domest Anim 2018; 53 Suppl 2:70-73
- Local vessels ultrasonography evaluates prostatic physio-pathologic states. Testosterone promotes tissue and vascular growth. Knowing variables on prostatic vasculature is crucial to correctly apply ...
Local vessels ultrasonography evaluates prostatic physio-pathologic states. Testosterone promotes tissue and vascular growth. Knowing variables on prostatic vasculature is crucial to correctly apply Pulsed-Wave exam. The study aims to assess how ejaculation and blood testosterone affect Pulsed-Wave indexes. Serial blood testosterone dosages and Pulsed-Wave exams were performed in 20 dogs, immediately before (T0) and after (T1) ejaculation and 6 hr later (T2). Arteria prostatica cranialis, Arteriola capsularis, Arteriola trabecularis and Arteriola parenchimalis were evaluated and mean Pulsatility and Resistivity Index, Systolic-Peak, End-Diastolic and Mean Velocity calculated. Data were grouped by time and vessel (ANOVA, p ≤ 0.05). At T1, Resistivity Index significantly lowered in A. prostatica cranialis, A. trabecularis and A. parenchimalis but grew in A. capsularis; Pulsatility Index had the same pattern, but not significant in A. parenchimalis; Systolic Peak Velocity, End-Diastolic Velocity, Mean Velocity significantly rose in A. capsularis and A. trabecularis. No indexes differed at T0 and T2. Testosterone did not differ at T0 (10.93 ± 7.05 ng/ml), T1 (12.71 ± 7.29) and T2 (10.54 ± 6.63). Results stated the risen prostatic vascular flow postejaculation, affecting Pulsed-Wave. Due to semi-rigid capsule, impairing vasodilation of other vessels, only A. capsularis indexes increased. Intimal cushions of A. prostatica cranialis kept velocities fixed; A. capsularis and A. trabecularis lack of intimal cushions, thus velocities grew. In A. parenchimalis, precapillary sphincters opening allows increased flow redistribution in vasodilated parenchymal bed, keeping velocities fixed. As testosterone, not affected by ejaculation, did not peak, vascular changes are not due to testosterone itself. These physiological effects of ejaculation suggest proper sexual rest before Pulsed-Wave exam planned to explore suspected prostatic neovascularization.
- Identification of the Anabolic Steroid 6β-Chlorotestosterone in a Dietary Supplement. [Journal Article]
- DTDrug Test Anal 2018 Sep 20
- Capsules that were labeled to be a performance-enhancing dietary supplement obtained during an investigation, were found to contain an unrecognized steroid-like substance. This compound was isolated ...
Capsules that were labeled to be a performance-enhancing dietary supplement obtained during an investigation, were found to contain an unrecognized steroid-like substance. This compound was isolated by liquid chromatography (LC) fraction collection and characterized using several qualitative analytical techniques, including ultraviolet (UV) spectroscopy, gas chromatography-mass spectrometry (GC-MS), liquid chromatography-high resolution accurate mass-mass spectrometry (LC-HRAM-MS), as well as 1 H, 13 C, and two-dimensional nuclear magnetic resonance (NMR) spectrometry. This multi-technique analytical approach was used to identify the designer steroid as 6β-chloro-4-androsten-17β-ol-3-one (6β-chlorotestosterone), an analog of testosterone about which little has been published.
- Semi-Quantitative Determination of Designer Steroids by High-Performance Liquid Chromatography with Ultraviolet Detection in the Absence of Reference Material. [Journal Article]
- DTDrug Test Anal 2018 Sep 20
- New designer steroids are continually being encountered in dietary supplements that claim to increase muscle mass, but quantitative analysis of such ingredients is challenging due to the availability...
New designer steroids are continually being encountered in dietary supplements that claim to increase muscle mass, but quantitative analysis of such ingredients is challenging due to the availability, quality, or cost of commercial reference materials. Although standard reference material typically becomes available for these emerging compounds, laboratories often face the challenge of finding properly certified materials from accredited suppliers, due to traceability requirements. Several of these designer steroids have been isolated and identified using multiple structural elucidation tools. Structural characteristics of these compounds of interest were evaluated and molar absorptivity data was collected and compared to several readily available steroid standards using ultraviolet/visible spectroscopy. This approach was used to find suitable compounds for use as surrogate reference materials in the semi-quantitative determination of two designer steroids, 1-androsterone and 6β-chloro-4-androsten-17β-ol-3-one (6β-chlorotestosterone). Laboratory fortified matrix samples and dietary supplement samples were analyzed using this method for the estimation of 1-androsterone and 6β-chlorotestosterone by HPLC-UV. Assay values obtained for the estimation of 1-androsterone in a dietary supplement sample using a prasterone or dehydroepiandrosterone (DHEA) standard curve were 100% of those obtained using a 1-androsterone reference standard, once it became commercially available. Estimations for 6β-chlorotestosterone in laboratory fortified matrix samples using a testosterone standard curve were 92-93% of those obtained using isolated 6β-chlorotestosterone as "reference material."
- Human body symmetry and immune efficacy in healthy adults. [Journal Article]
- AJAm J Phys Anthropol 2018 Sep 20
- CONCLUSIONS: Our results are the opposite of the good genes hypothesis prediction and suggest that in western, healthy populations, human mate preferences for more symmetric bodies are not related to immune competence.
- A novel dehydrogenase 17β-HSDx from Rhodococcus sp. P14 with potential application in bioremediation of steroids contaminated environment. [Journal Article]
- JHJ Hazard Mater 2018 Sep 10; 362:170-177
- Steroids are endocrine disrupting compounds in human and are distributed in various environments. Our previous study showed that a marine bacterium Rhodococcus sp. P14 was able to efficiently degrade...
Steroids are endocrine disrupting compounds in human and are distributed in various environments. Our previous study showed that a marine bacterium Rhodococcus sp. P14 was able to efficiently degrade one typical steroid estradiol. In this study, we showed that P14 could also use other steroids, including estriol and testosterone, as sole carbon source for growth. Two dehydrogenation products, 16-hydroxestrone and androst-4-ene-3, 17-dione, were detected during estriol and testosterone degradation, respectively. By screening the genome, a short chain dehydrogenase gene was identified and named as 17β-HSDx. Expression of 17β-HSDx was induced in P14 when estriol, estradiol or testosterone was used as single carbon source. In addition, 17β-HSDx was shown to have dehydrogenation ability of transforming estriol to 16-hydroxestrone, estradiol to estrone and testosterone to androst-4-ene-3, 17-dione. This is the first short chain dehydrogenase identified in bacteria with dehydrogenation ability on various steroids substrates. Overall, this study reveals that 17β-HSDx has potential application in the bioremediation of steroids contaminated environment.
- A novel role for zinc transporter 8 in the facilitation of zinc accumulation and regulation of testosterone synthesis in Leydig cells of human and mouse testicles. [Journal Article]
- MMetabolism 2018 Sep 17
- CONCLUSIONS: The present study provided the first evidence that ZnT8 transports Zn into Leydig cell mitochondria with gonadotropin stimulation and suggests that ZnT8 may play a role in testosterone production via the PKA signaling pathway.
- Hair hormones in male youth with internet gaming disorder. [Journal Article]
- WJWorld J Biol Psychiatry 2018 Sep 20; :1-6
- CONCLUSIONS: Unlike other psychiatric disorders, effects of IGD and associated psychopathology on basal HPA axis functioning, indexed by hair hormone levels, are negligible. Future studies need to rule out potential effects of sex, age and long-term pathology on these findings.
- Influence of testosterone substitution on glycemic control and endothelial markers in men with newly diagnosed functional hypogonadism and type 2 diabetes mellitus: a randomized controlled trial. [Journal Article]
- AMAging Male 2018 Sep 20; :1-9
- Effects of testosterone (T) on the cardiovascular system of men remain controversial. The impact of T-replacement therapy (TRT) in men with functional hypogonadism and type 2 diabetes mellitus (T2DM)...
Effects of testosterone (T) on the cardiovascular system of men remain controversial. The impact of T-replacement therapy (TRT) in men with functional hypogonadism and type 2 diabetes mellitus (T2DM) has to be elucidated. This study included 80 men (mean age 51.5 ± 6.3 years) with newly diagnosed T2DM (according to ADA criteria) and functional hypogonadism (according to EAU criteria). Randomization: Group1 (n = 40): TRT using 1%-transdermal T-gel (50 mg/day), Group2 (n = 40) no TRT (controls). Dietary treatment applied to both. Parameters at baseline/after 9 months: anthropometric parameters, lipids and indicators of carbohydrate metabolism (fasting glucose, insulin, HbA1c, HOMA-IR), markers of adipose tissue and EnD (leptin, resistin, p- and e-selectin, ICAM- 1, VCAM- 1 and CRP). ANCOVA for repeated measurements revealed TRT to cause a significant decrease in waist circumference (WC), HOMA-IR and HbA1c vs controls (p < .001, p = .002, p = .004, respectively). Leptin declined in subjects receiving TRT vs controls (p = .04). Concentrations of resistin, ICAM-1, p-selectin and CRP decreased significantly vs controls (all p < .001); no effects for e-selectin and VCAM-1. Advanced age attenuated effects, higher delta testosterone levels augmented effects. Decrement of WC was related to decreasing markers of adipose tissue secretion/EnD. TRT in men with functional hypogonadism and T2DM improved carbohydrate metabolism and markers of endothelial dysfunction.
New Search Next
- Increased influenza-specific antibody avidity in HIV-infected females compared to HIV-infected males on antiretroviral therapy. [Journal Article]
- AIDSAIDS 2018 Sep 17
- : It is recommended that HIV-infected individuals receive annual influenza vaccination due to their high susceptibility to influenza infection, especially among females. However, there have been few ...
: It is recommended that HIV-infected individuals receive annual influenza vaccination due to their high susceptibility to influenza infection, especially among females. However, there have been few studies investigating sex-related responses to influenza vaccine in antiretroviral (ART)-treated HIV-infected subjects. In this study, 26 aviremic ART-treated HIV-infected subjects and 16 healthy controls were enrolled in the current study. Blood was collected prior to vaccination (D0), on days 7-10 (D7), and on days 14-21 (D14) following administration of the 2013-2014 seasonal influenza vaccine. A series of analyses evaluated the serological and cellular responses following influenza vaccination. Female HIV-infected subjects had increased influenza-specific antibody avidity relative to male HIV-infected subjects, but similar plasma levels of influenza-specific binding antibodies and neutralizing antibodies. Increased cycling B cells and follicular helper CD4+ T (Tfh) cells were observed in female HIV-infected subjects pre- and post-vaccination compared to male HIV-infected subjects, and cycling Tfh cells were directly correlated with influenza-specific antibody avidity. Moreover, plasma testosterone levels were inversely correlated with antibody avidity index. The magnitude of microbial translocation (plasma lipopolysaccharide (LPS)) level was directly correlated with influenza-specific antibody avidity. Circulating 16S rDNA microbiome showed that enrichment of specific species within Proteobacteria was associated with influenza-specific antibody avidity. These results, including differences based on sex and correlations, were only observed in HIV+ subjects but not in the healthy controls. This study demonstrated sex differences in influenza-specific antibody avidity in ART-treated HIV disease, and provides valuable information on vaccination strategy in the ART-treated HIV-infected population.


The Peregrine is a medium fighter/interceptor designed to assist in fleet actions by forcing the enemy to split their fire between as many targets as posible. The craft are designed primarily to operate at impulse or low warp speeds near to their home base, or from a suitable carrier vessel such as an Akira class. While they are capable of warp speeds, the Peregrine is not a true interstellar vessel.
In design Peregrines are relatively conventional - there is a large pair of impulse engines at the rear, flanked by the warp nacelles. The cockpit is in the forward section, as are the micro torpedo launchers. Phaser armament comprises a single phaser cannon in the nose and a pair of cannon on the wings. There are two cockpits available; the one-person cockpit uses the rear space for extra equipment, while the two-person model allows the workload to be split, enhancing crew performance. Both types exist in several different models which are optimised for various roles and operating conditions.
The Peregrine has seen considerable service since the Dominion war, and has suffered heavy losses. Nevertheless, these ships continue to fulfil a vital role and production is continuing even to this day.


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I have a good friend who works in a local urgent care as a PA. A week or two ago she mentioned that it was going to be National Nurses Day coming up (it was actually last Friday, May6) and she wanted to bring a bunch of homemade goodies into the urgent care as a thank you to all the nurses she works with. She was hoping that Lara and I could help her out with some decorated sugar cookies, the type we usually make at Christmas. Of course we both jumped on board right away and last week the three of us got together to do some decorating.
After browsing Pinterest, we settle on three design ideas, EKG hearts, bandages, and nurses caps. All three designs were very simple to make and turned out great! The perfect way to say Thank You to all those nurses out there who work incredible hard to give their patients the best care possible. So although this is a few days late; Happy Nurses Day!!
These cookies were a team effort. I made the cookies the day before we were planning on decorating and Lara made the royal icing that night and frosted the cookies with the base layer so they would have time to dry. The next day we headed over to our friends house and completed the decorating. So while there were a few different steps involved, the whole process was pretty easy and didn't take very long at all!
Vanilla-Almond Sugar Cookies
from Bake at 350
- 3 cups all-purpose flour
- 2 teaspoons baking powder
- 1 cup sugar
- 2 sticks butter, cold
- 1 egg
- 3/4 teaspoon pure vanilla extract
- 1/2 teaspoon pure almond extract
Combine the flour and baking powder, set aside. Cream the sugar and butter. Add the egg and extracts and mix. Gradually add the flour mixture and beat just until combined, scraping down the bowl, especially the bottom.
The dough will be crumbly, so knead it together with your hands as you scoop it out of the bowl for rolling
Roll onto a floured surface and cut into shapes. Place on parchment lined baking sheets and freeze for 5 minutes. Bake chilled cookies for 10-12 minutes at 350. Let sit a few minutes on the sheet, then transfer to a cooling rack to cool completely.
- 6 oz (3/4 cup) warm water
- 5 tablespoons meringue powder
- 1 teaspoon cream of tartar
- 1 kilogram (2.25 pounds) powdered sugar
*** Note: if your meringue powder has no vanilla flavor in it, you may add a teaspoon of clear vanilla to this recipe
Pour the warm water and meringue powder into the bowl of an electric mixer. Mix it with a whisk by hand until it is frothy and thickened, about 30 seconds.
Add the cream of tartar and mix for 30 seconds more.
Pour in all of the powdered sugar at once. Using the paddle attachment, mix slowly, on the LOWEST speed, for a full 10 minutes. Icing will get thick and creamy.
Cover the bowl with a dampened towel to prevent crusting and drying.
Tint with food colorings and thin the icing with small amounts of warm water to reach the desired consistency.

domain: food


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In southern San Luis Obispo County you’ll find Santa Maria, home of the famous barbecue meats. Just to the north, you’ll travel through five cities featuring Pismo Beach, famous for clam chowder. The active center is the city of San Luis Obispo. During school months this city is populated with students from CalPoly. At the north just beyond Cambria, you can observe the elephant seals as they bask in the sun.
Aside from the famous wine tasting, the areas’ popular activities include walking, hiking, biking, golfing, beer sampling or visiting a California historic mission, If you love the water, you can kayak, surf, fish, whale watch, take a swim or just watch the Pacific’s mighty waves. Don’t miss San Luis Obispo’s Farmer Market on through downtown on Higuera Street every Thursday evening from 6:00p.m. to 9:00p.m.


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domain: game


Automation specialist ABB’s tabletop operator control unit of its new Remote Control Station (RCS) won the prestigious ‘red dot award’ of 2014, which ABB exhibited during the recent TOC Europe.
ABB triumphed over the competition of 1,800 manufacturers, designers and architects from 53 nations.
40 experts analysed the level of innovation, functionality, durability and ecological compatibility in each submitted design.
Head of ABB’s marine and cranes business, Heikki Soljama, stated that: “The new design of the RCS tabletop unit was created following ABB’s ‘Operator in Focus’ concept. This addresses crane operators’ performance as the container handling industry continues to expand the scope of remote operations and searches for ways to improve productivity as ships get larger and cranes taller.”
The ABB Group operates in around 100 countries worldwide and also won the red dot award in 2013; reflecting the consistent level of innovation the company is known for.


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Resonance FM: Everything
Summary: Every single Resonance FM show which has ever been released as a podcast.
Join the angry side by Stewart Home from the CD Stewart Home comes in your face, Motor City is burning by The MC5 from Kick out the Jams, Happy Jack by The Who Live at Leeds University 1970, and The Wolfman (1964) by Robert Ashley; tape, voice and feedback, produced at the University of California [...]
Laydeez do podcasts: Promoting comics In two talks recorded at Laydeez do comics, the first in a new season of Laydeez do podcasts, Charles Hatfield talks about comics academia and Jay Eales and Selina Lock discuss publishing The Girly Comic. Hatfield is the author of ‘Alternative Comics: An Emerging Literature’ and ‘Hand of Fire: The [...]
In this Six Pillars show we tap into the fine array of people at Share Conference, Belgrade for a short journey of discovery. We discuss Iran’s move towards a closed, national intranet which they can then fully censor, with a leader in the global free-internet culture movement: Elizabeth Stark. Elizabeth presented a talk at Share [...]
John Cage is said to have called her ‘that beautiful Persian girl‘, Jackson Pollock, though unfriendly, openly declared an admiration for her art. Born 1924 in Iran, Monir Farmanfarmaian later brought a flavour of Iran to New York’s avant garde, amongst whom she was circulating. One of her pieces is said to have been [...]
first show back after our summer break, featuring alvaro ortiz, cedric anglaret, flavien gillie, james torrance, john barber, keith de mendonca, kim walker, luis antero, virgilio oliveira, mecha/orga, and a framework intro by joe stevens.
How will you spend Christmas by Reverend A.W. Nix; Fighter Pilot’s Christmas by Captain Richard Jonas; How I hate to see Christmas come around by Jimmy Witherspoon; Santa Claus goes modern by Rod Rogers, Teri Summers and The Librettos; Christmas Time by Black Ace; No Christmas in Kentucky by Phil Ochs; Did you spend Christmas [...]
Electric Sheep Podcast: Philosophy and Murder Alex Fitch talks to film critic and historian Kim Newman about The Edgar Wallace Mysteries, a series of British B movies made in the 1960s and subsequently rebranded as a TV series, based on novels by the co-creator of King Kong. Plus: in a Q and A recorded at [...]
Reality Check: Counter Measures In the second of a pair of podcasts about Doctor Who audio spin-offs, Alex Fitch talks to actor John Banks, producer David Richardson and director Ken Bentley about Counter Measures, a new Nigel Kneale influenced audio drama that continues the story of the supporting cast from Doctor Who: Remembrance of the [...]
framework is on summer holidays; we will be back with new programming in september. this show from the archives originally aired on 2008.12.14.
Panel Borders: Taming the Elephantmen In a companion podcast to last week’s episode, Alex Fitch continues his conversation with writer Richard Starkings and artist Ian Churchill about Elephantmen, a sci-fi anthropomorphic comic about animal / human hybrid soldiers coming to terms with life in the big city after being demobbed. In a Q and A [...]
Conversing with Resonance apparatchik Richard Thomas on Tenerife, anti-design, a Markson piano, ResoVision, and the recent student demonstrations.
Reality Check: The Minister of Chance In the first of pair of podcasts about Doctor Who audio spin-offs, Alex Fitch talks to the writer / director, Dan Freeman, and one of the stars, Paul Darrow, of The Minister of Chance. The series is a crowd-funded, mp3 download serial which follows the SF / fantasy adventures [...]
Panel Borders: Unleashing the Elephantmen Alex Fitch talks to writer, editor and letterer Richard Starkings, and Ian Churchill, one of a rotating team of artists on Elephantmen, an American monthly comic (primarily created by Brits) about retired super-soldiers that are half animal, half human hybrids. Mixing the sci-fi / noir ambience of Blade Runner with [...]
framework is on summer holidays; we will be back with new programming in september. this show from the archives originally aired on 2008.11.30.
Download show here For more download & listening options, visit Archive dot org

domain: artistic


text: This article discusses the lived experience of professional identity during the transition from student to newly qualified practitioner. Current literature emphasises the first year of practice as an important time of transition to a job-role as student social workers move into postqualification practice. However, little research has explored how professional identity is experienced during this significant transition period. A phenomenological research project was undertaken with 17 newly qualified social workers in Australia. Three in-depth semistructured interviews were conducted with each participant across the first 12 months postqualification period. Participants described how they resolved personal, relational, and professional questions about becoming and being a qualified social worker. The findings indicate a need for educators, employers, supervisors and the profession to consider how to better integrate professional identity within curricula, policy, and systems of support, including supervision. IMPLICATIONS Findings from a qualitive study indicate the initial postqualification period involves consolidating, clarifying, and settling into professional identity as a newly qualified social worker. Educators should consider a holistic approach to curriculum development regarding professional identity and how they prepare graduating students to transition from university to qualified practice. The Australian Association of Social Work, supervisors, and managers are prompted to recognise and support the changing and evolving professional identities of newly qualified practitioners.

domain: sociology


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3 - This beachy design uses white and sea foam green to immediately transport you to Cape Cod or another seaside town. The bedrooms are not large, but the centralize living area and patio leave space for ultimate relaxation.
The Perfect Log Cabin Log homes are one of the most resistant types of home and they are also very affordable. For centuries, people around the world have been living in log homes and they seem to be quite popular nowadays too. This next cute tiny log ho
Katy Ann Gilmore - Visual artist living in Los Angeles. Working in sculpture, installation, and drawing/painting, Her work is currently influenced heavily by topography and the relationship between perpendicular planes and their distortions into space.


Trackimo Global GPS Smart Watch - GPS/Built in SIM card/Wi-Fi/Bluetooth..
Know where your loved ones are even when you can't be with them. Constantly monitors the wearer's location and has a SOS button for moments of distress.
Have peace of mind knowing where your child, elderly family members and dear ones safe! Watch the safety of people who need care and assistance. Trackimo 3G GPS Smart Watch is including a built in SIM card loaded with 1 year international worldwide cellular service, no roaming fees. Device is working out of the box easy to use, up and running within minutes.
Best Suitable for:Children, Teens, Adults, Elderly loved ones, Adventure and outdoor people and more.


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Thursday, December 3, 2015
elf - The Broadway Musical - A Review
Santa Claus. Elves. Snow. Tidings of joy. Festive theatre goers. Children of all ages.
These are just some of the sites you will encounter this week at the historic Fox Theatre when it welcomes, "elf, The Broadway Musical" to stage.
The holiday classic movie, elf, has been transformed into a musical. Yes. You heard me correctly. A musical.
To be truthful with you, I was excited. My boys and I love this movie. We love Will Ferrell. We love the premise of the movie, and we love the quirky elf's personality. It's one of those classic holiday movies, like National Lampoon's Christmas Vacation, that lives on from year to year with its own cult following.
So, to say I didn't have high hopes for the play would not be correct.
It looked like several people in attendance had the same idea. Men in bright green Buddy the Elf vests. A whole group of people in elf t-shirts. Small children everywhere, dressed in their best holiday attire.
So, I believe we were all in accord. High hopes to see the story we love so much.
Alas, however, what we were delivered left a little to be desired...
Don't get me wrong. The talent in this play was superb. Gabrielle Mirabella as Emily Hobbes was fantastic. Daniel Patrick Smith as Buddy was also a supreme talent. But - it's not the talent that was lacking. It was the story line.
For instance, let me explain. I brought a guest with me to the performance. A person that had never seen the motion picture version of elf before. She didn't "get" the cult following or most of the humor of the play. Places where the audience laughed out loud, she sad motionless and quiet.
In fact, as the first act progressed and I, too, lost interest in the story line, I began to look around. Most of the people sitting around me were either scrolling through their phones, yawning, or also sitting motionless and not laughing. By the second act, several of the people sitting around us had left during intermission and a few more left at the beginning of the second act (which I think was actually much stronger than the first). Lines like, "Santa? I know him!" brought very little laughter.
Such a shame. The movie is joyous and fun and catchy. The musical is a brief "cliff notes" version of the movie - leaving most of the substance out and the foundations upon which the ties of family and love are built around.
My friend asked me on the way home what certain parts meant because, if you had not seen the movie, the pieces of the story didn't seem to thread together very well. On several occasions, I had to explain the movie to her and what was going on within a particular scene.
Most of the songs were done well, but a few just weren't catchy. I think the play could have been so much more. Could have captured Buddy and his zest for life and love and family so much better. In fact, to prove this point -- one of the last lines of the evening?
Buddy and his new wife Jovie, along with their new baby, are visiting Santa and Mrs. Claus at the North Pole (somewhat reflective of the movie's ending), but Buddy announces to the audience something like this (don't hold me to this verbatim, but you will get the idea), "I love hugs! I love singing after hugs. In fact, I got married and learned a whole new kind of hug and I sang at the end of it and now we have a baby!" WHAT?
Is that even appropriate for this play or for the myriad of children in the audience? Maybe it just went over their heads, but the grownups in the audience caught it for sure.
I don't know. Maybe it's just hard taking a beloved holiday movie and twisting it around a bit. I know the people with children sitting behind us left during intermission. This just wasn't the same Buddy or the same elf story. Too many twists on the original tale and not enough of the original story line. It was like a skeleton of the original with all the skin and internal mechanisms missing.
If you love Buddy the elf and his holiday movie making the television rounds right now, keep an open mind when you venture out to see the musical. Maybe it was just me. But I wouldn't go see this play again. Just not at all what I envisioned.
If you go see it and have a different opinion, I'd love to know or hear about it. Chat me up on facebook or leave a comment below. Maybe I missed the mark somehow, but I'd love to hear your thoughts!
NETworks Presenations' elf will be playing The Fox Theatre through Sunday (December 6). To get tickets, you can visit The Fox Theatre's website.


Hibernian defender Callum Booth accidentally hit a seagull flying above the pitch during Tuesday’s pre-season friendly with Dunfermline. Unlike some soccer players, the seagull didn’t dive and start rolling around on the ground. Instead, the bird regained composure and flew out of the stadium.
A 5’9″ “short” Israeli tennis player, Dudi Sela, needed a chair to give his opponent (and a friend), 6’11″ tall Croatian Ivo Karlović, a post-match hug at the Claro Open Colombia in Bogota, on Thursday.
Sky News political editor Adam Boulton ended up swallowing a fly while reporting from Downing Street on British Prime Minister’s cabinet reshuffle. He took it like a pro:
A seaplane almost hit a whale while landing on water in Angoon, Alaska, on July 10. Luckily, the pilot managed to pull the plane up just in time to avoid a collision with the surfacing whale. Thomas Hamm caught the close call on camera.
Remember the ‘Haynes Baked Beans’ astronaut ad? Here’s the 2014 World Cup version which illustrates Germany’s road to the final against Argentina:
The world’s largest underground trampoline has been unveiled in a cave in North Wales. It’s expected to be a popular attraction, but it’s definitely not for the faint hearted. Watch the BBC News report:
Did you ask yourself how is it possible that Brazil lost the 2014 World Cup semi-final to Germany with such a high score? This footage explains everything:
Troy and Kristin Dickerson were racing from Rosenberg to Texas Children’s Hospital, in Houston, for the birth of their third child. But, they didn’t quite make it there in time. Their baby boy, Truett, was born outside the hospital’s valet entrance. Dad managed to film the crazy ride to the hospital and the birth with a GoPro camera strapped to his head:
Argentina’s Alejandro Sabella forgets about gravity for a moment during Saturday’s World Cup quarter-final match against Belgium.
During Saturday’s basketball match between Mexico and Slovakia, at the 2014 FIBA Under-17 World Championship for Women, a Slovakian player managed to score against her own team after a Mexican player missed a free throw. Right after that, the Mexican side started their attack…in the wrong direction! What’s even worse – the refs allowed them to put the ball back into play. Unreal!


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Stress Belly and Hormonal Weight Gain A lot can be done to transition gracefully into each phase of adulthood for women—and men—by gaining a foothold against stress and managing hormones.
The subject of stress and hormones is important for everyone—both men and women. Women tend to have more questions about the role hormones play with regard to weight, particularly weight changes during perimenopause and menopause and also weight changes during their menstrual cycle. As men get into andropause, they struggle to keep their weight down. Hormones are constantly fluctuating and changing, but they play a key role in all these issues.
Our bodies have a single integrated system known as a super system that includes the neuro (brain), endocrine (hormone) and immune (gut) systems. There is crosstalk among these three systems, so for example, any dysregulation in the gut will impact and influence the brain and hormones. So when we talk about losing weight and overall health, we’re talking about the integration of all three of these systems. This is why losing weight is about getting healthy first and foremost.
The endocrine system begins with the hypothalamus in the brain, which sends messages to the pituitary gland. Think of the hypothalamus as the CEO of the hormone corporation and the pituitary gland is the president that answers to the CEO. Taking orders from the pituitary (president) are other glands that we can think of as factories that pump out their own hormones, which also have crosstalk of their own: pancreas (insulin), thyroid (metabolism), adrenal (stress), ovaries/testes (reproduction), pineal (sleep), and thymus (immune).
All together, these make up our hormone system, and the brain regulates and controls them all. So when there is an imbalance in gut health, it communicates this imbalance to the brain which then creates an imbalance in the hormones as well. (For more detail on the hormone cascade and how these chemical messengers interact with our genes, watch the Day 3 5lb Challenge video or read the Day 3 Energy Challenge blog post.) This is why the standard medical model of treating only one of these areas where symptoms occur doesn’t work. The functional medicine model instead looks at the mechanisms in the entire super system that is driving the hormone cascade.
Stress plays a huge role in weight and belly fat. As most people know, there’s good stress and bad stress. Gravity is considered good stress in that it keeps muscles and bones strong; for some people, deadlines create good stress because it makes them more productive and creative. On the other hand, we want to avoid the two main types of bad stress: emotional stress (worry and fear) and, less recognized, physiological stress (negative chemical changes in the body such as blood sugar, underlying infections, poor sleep, etc.). When there is a stress overload, our bodies reach a point where they simply can’t handle it anymore.
It’s important that all hormones are able to be metabolized and cleared by the body. There are three parts to hormones: production (messages sent from the brain to the glands telling them to manufacture hormones), activation, and elimination (metabolism). Estrogen metabolites are pro-inflammatory, can cause oxidative stress and are toxic, so it’s important that these metabolites are eliminated from the body or else they’ll back up and accumulate. Estrogen that is not cleared will be stored as fat; likewise, fat in the body will accumulate estrogen, which becomes a vicious cycle. In addition, we accumulate an abundance of toxins from everyday life, known as obesogens, which are chemicals in the environment that cause obesity—these are endocrine disruptors.
Many of these chemicals come from eating industrially farmed meats as well as non-organic fruits and vegetables that have been sprayed and grown with pesticides, herbicides, and fungicides. Choosing organic foods helps to lower the toxic load overall. In addition, BPAs are the number one top hormone disruptor; these are commonly used in plastic bottles, cash register receipts, and cans.
The good news is that there are a number of strategies to detoxify. These include increasing fiber and water intake, bone broth and limeade fasts, consistent exercise, using an infrared sauna, and supplements—the goal is to detoxify important organs like the liver, gallbladder, lymphatics, and kidneys.
Learn more about how stress physiology affects weight, or how hormone balance can assist with weight loss by tuning into Module 3 of The Down5 Pounds Challenge.
Participants who have implemented the strategies learned in the 5-Day LIVE Weight Loss Challenge have reported less pain, fewer headaches, more energy and weight loss. However, The Down5 Pounds Challenge is not the promise of a cure and does not constitute medical advice. To learn more about The Down5 Pounds Challenge: How to Curb the Midlife Madness Overtaking Your Gut!, please visit our website at learn.getwell-now.com. For questions or To dig a little deeper into your own unique biochemistry or learn about root cause healing and functional medicine, visit us at Get Well Now and schedule a Discovery Call.
About Dr Pucci - Dr. Doug Pucci, Founder, Pucci Wellness Center, is a functional medicine pioneer and Bergen County’s Face of Functional Medicine. He was honored to receive both The Best Of 2020 Awards for Functional Medicine in Oradell, NJ, and entry into Trademark Publications’ 2020 Who’s Who Directory, Honors Edition. Contact (201) 261-5430.
Food 101 is about food, and specifically how food is metabolized into energy. Why excess energy from simple carbohydrates induces a stress response that produces fat.
We begin to examine the food we eat and separate the “good” from the “bad” in each category (carbohydrates, fats, proteins). There are so many myths about food, fad diets, dietary strategies, and so on, that we want to tease these apart. All too often patients become paralyzed about what to put in their mouths or on the table.
Gaining Weight, Eating Too Often and Still Craving the Wrong Foods? is a primer on some of the ways that even a good dietary plan, such as keto, paleo and vegan, can go wrong.
The gut is not a sterile or empty environment. Indeed, it is filled with life. Learn about the GI Effects test from Genova, and the gastrointestinal tract. This test gives us indications for five broad categories that affect digestion and colon health: maldigestion, inflammation, dysbiosis, metabolic imbalance and infection.
Gut Health and Weight Loss is a look at why starving ourselves to lose weight isn’t the answer. And for most people, an excessive amount of exercise isn’t either.
Fiber is Key to a Healthy Gut Microbiome is about the life teeming inside and the fuel it craves. We’ve always known that fiber-rich foods are important to good health, but scientists are now finding out why.
Why A Diversity Of Probiotic Strains Matters? How to know whether the probiotics we’re taking are right for us? Is yogurt really the best choice? Dr. Pucci explains why diversity matters.
Stress Eating and Healthy Weight is about avoiding the tendency for takeout and a few suggestions for stress management techniques.
Toxic Stress is Causing Leaky Gut is about how cortisol stress begins to erode our barrier system, the lining of our mucosa, when toxins permeate the gut.
Foods that Trigger Immune Reactions is about the pro-inflammatory nature of modernized grains, fats and dairy and why these trigger an immune reaction.
Food Scores Download the EWG (Environmental Working Group) App application to learn which of our produce is ranked highest in pesticide use and which is adhering to pesticide free guidelines.
Answers to Listener Questions A ton of questions came up during the LIVE taping. Register for The Down5 Pounds Challenge to review the complete list of answers related to food, what we eat and why.
Easy Breezy Morning Routine is about the 10 tiny habits that will create change and even transform the day.

domain: medical


The UK's Financial Conduct Authority (FCA) has today launched its updated Financial Services (FS) Register - including a simpler design and clearer language in a bid to protect consumers from financial harm.
The register - which had more than seven million unique users in the past year - is a service for anyone that wants to see firms and approved individuals that are involved with regulated activities.
It can help consumers avoid scams and enables firms to cross-check references and make their key staff known to customers, the FCA said. The enhanced Register has been tested with consumers and other users to ensure it is easier to use and understand.
The FCA said that it will "review and improve" the FS Register on an ongoing basis, to ensure it meets the needs of users.
Jonathan Davidson, Executive Director of Supervision - Retail and Authorisations, said: 'The Financial Services Register is an important tool for both the consumers and firms who use it.
'These changes will make it easier for users to navigate and understand the Register, and in doing so, help them avoid financial harm such as scams by unauthorised firms and individuals."
Under the Senior Managers and Certification Regime (SM&CR), the FCA had announced its commitment to publishing and maintaining a directory of certified and assessed persons on the Financial Services Register. Having already announced a delay to this, the FCA now intends to publish it later this year.
The FCA is also currently proposing to extend the previous deadline of 9 December 2020 for solo-regulated firms to submit information about Directory Persons to the Register to 31 March 2021.


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When you find yourself epidemiologic exposure get identify higher-risk people, one patient may over suicide; thus, systematic “warning flags” are likely probably the most convenient identity device you to doctors need to http://www.datingranking.net/pl/e-chat-recenzja avoid suicide.
Self-destructive ideation and you can contemplating committing suicide try predictive regarding suicide. Self-destructive ideation and you can history of suicidal decisions are among the very salient short- and you may enough time-name risk circumstances having committing suicide.[24,25] While there is always a prodromal period of self-destructive ideation (presuicidal disorder), which can vary from transient and you may couch potato to ruminative and you will turbulent and you may trigger suicidal planning otherwise enactment, suicide can occur impulsively as opposed to quick alerting. That is to say, self-destructive ideation and real committing suicide don’t usually are present together. It is very common proper facing mortality via a chronic scientific disease, especially those resulting in extreme morbidity (such as for instance, neurological problems), so you can think about death as well as suicide when it comes to “possibly X might possibly be better off as opposed to me personally.” This type of mind is linked to a lives improvement, and should become transient and never overtly bothersome or chronic. When self-destructive ideation becomes persistent otherwise ruminative, clients may turn to feel risky. Chochinov et al learned that forty-two.5% from 2 hundred terminally ill patients claimed a momentary curiosity about passing, if you’re 8.5% had a very lasting desire for passing. Often there is ambivalence, settlement, and you may equivocation from the suicide and you can, using this type of suspicion, mental health therapy can effortlessly intervene. Clients may start that have phenomenal thought or searching for cues to help them pick whether or not to to visit committing suicide. In the a deeper number of suicidality, patients have conceived an idea that will be passed both impulsively (instance, due to uncontrolled feeling, lack of ability to regulate feelings, otherwise facing disappointment) or even in an intentionally managed means. Clients will enact a beneficial self-destructive motion that isn’t in reality suggested to-do suicide but means interior negation or preparing. Regrettably, these types of acts are usually inadvertently fatal. Also so far, partners customers try it really is clear on their decision and certainly will have a tendency to reach because of refined gestures. These people is going to be assisted significantly by the a smart clinician which sees alterations in knowledge, feelings, and you can identity.
Curiosity about Hastened Dying
Another aspect of suicidal convinced into the people that have cancer ‘s the emotional construct referred to as desire for hastened dying (DHD), or the dreaming about demise that occurs faster than just it if you don’t do. DHD incidence may differ however, grows if you’re handling the conclusion existence and is more widespread in palliative and you can hospice settings. The most used reasons known for DHD tend to be depression, hopelessness, feeling of being a weight so you’re able to other people, and you will forfeiture regarding personal freedom. State attacks was basically also provided within very cited points, and anxiety about soreness or any other envisioned distress. Just like self-destructive ideation, depression and you may hopelessness have been discovered becoming separate products relevant to DHD. There are validated steps to have assessing DHD into the a clinical setting, including the most commonly used Plan off Thinking towards Hastened Passing and Curiosity about Death Get Size.[twenty-seven,31]
The suitable method of approaching DHD try unsure. DHD is highly synchronised with despair; for this reason, approaching root anxiety is actually a suitable means. It’s been suggested you to DHD responds in order to psychological help specifically over other styles from spirits care and attention. For instance, problems government will not fundamentally match a decrease in DHD. Therefore, the crucial thing one to doctors promote enough psychological help.
Physician-Helped Suicide (PAS)
Jamais is actually judge for the Ca, Tx, Hawaii, Montana, Oregon, New york, and you will Washington, since . Demise which have self-esteem sculptures succeed adult condition citizens having a verified diagnosis away from six otherwise less days to reside so you’re able to accelerate the inevitable otherwise forthcoming demise. Claims are different into the tips to implement Jamais, however, appear to require multiple physician to concur, and additionally mental health ratings and you can waiting episodes. When you’re help-in-passing away laws and regulations should cover diligent self-reliance, new operate try burdensome for physician beneficence or nonmaleficence and you can stays debatable, which have opposition from some medical communities.

domain: psychology


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My blog is beginning to feel like my house does a lot of time at the moment, ever so quiet. Summer has definitely arrived for us and as a result we are outdoors as much as possible. The upshot of that is of course that when I am indoors I am catching up on chores or grabbing some sewing time and as a result I don’t have much time to sit in front of my computer and share my exploits with you all, and there is quite a lot to share. Swap packages have been arriving and heading off on their journeys. I’ve been quietly working away on some secret sewing – all should be revealed on that project on Friday.
And of course I’ve been working away on some EPP because it’s my favourite on-the-go, indoors, outdoors, travelling project type. If you’ve been following me on Instagram then you will know that one such project I have been working away on is a mini quilt for the #handpiecedminiswap that is being run by @lifeinlists over on Instagram.
I’m working on an octagonal design and have spent the last few weeks cutting papers, there are a lot, and covering them in preparation for sewing. It’s been a bit of a battle as I continuously change my mind about fabrics and colours.
Even now as I piece the quilt together I’m changing my mind on the decisions I made previously. The central octagon that I thought looked good when I did a trial layout of the first few rounds just doesn’t work for me now that the rounds are starting to be stitched together. I think it needs to be more solid, in a lime green or blue perhaps, something that pulls out more of the accent colours in the fabrics. I’m going to wait till the piecing is finished and then trial different fabrics till I find the perfect one. And who knows, maybe by the time it all comes together I will decide it does work after all.


Deer Lodge, Montana – The man who was found guilty in the 2017 death of Broadwater County sheriff’s deputy Mason Moore will be sentenced to the Montana State Prison, not the Montana State Hospital.
According to a press statement from the Montana Attorney General’s office, the decision was made as a result of winning arguments made by lawyers from the Montana Department of Justice.
Lloyd Barrus was convicted in September 2021 of three counts of deliberate homicide by accountability and two counts of attempted deliberate homicide in connection with his involvement in the May 2017 murder of deputy Moore.
“I’m proud that our DOJ prosecutors helped hold this dangerous criminal accountable for his actions and put him in prison where he belongs. Throughout this trial our team has been committed to finding justice for Broadwater County Deputy Mason Moore, his family, and all victims involved. I’m glad the court agreed with us and made the right decision today,” Montana Attorney General Austin Knudsen said in the press release.
A date for sentencing has yet to be set.


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A Vital Sign is a dramatic short-film by award-winning filmmakers Paul Robinson and Sashia Dumont. The story follows a unified group as they journey through the final chapter of their spiritual passage. The film was shot in the fall of 2019 in a historic 1880 farmhouse that is set on 135 bucolic acres in Ulster County New York. It is currently in awaiting responses from film festivals.
The dramatic short film was filmed on a $6k miro-budget, over four days in a private framehouse. With limited funds, same limited crew members, which resulted in a group effort by all. Despite last minute compilations, both cast and crew wore several hats during the production, creating lasting friendships
The cast on the film are Petra Denison, Sasha Dumont, Kieron J. Anthony, Kat Lindsay, and Ryan Katzer. The crew are Paul Robinson (Director/DoP), Sasha Dumont (Writer), Roo DeVito (1st AD/Gaffer), Thomas Myers (Sound), and Colin Felee (Grip).
Paul Robinson and Sashia Dumont are a husband and wife filmmaking team, based out of Hudson Valley, NY. Collaborating together since 2007, we joined artist forces to better conceptualize and create independent films and projects. Over the years this has helped us appreciate the importance of every cast and crew member, while helping us manage and maintain our production costs.
Sen3Productions is our award winning local film team. Our passion for filmmaking is something we love to share. In the past decade, we have made over a dozen films and sketches together, and truly look forward to every production. It is our mission to continue to create visual narratives, through original film and storytelling.
Tell us what you think of the “A VItal Sign“. What are you thinking? What more information do you need? Do you have any suggestions? Or did this help you? Lets have your comments below and/or on Facebook or Instagram! Or join me on Twitter @oladapobamidele
Guaxuma qualified to be considered for the 2020 Academy Awards
The post ‘A Vital Sign’ by Paul Robinson & Sashia Dumont is a Dramatic Delight appeared first on indieactivity.

domain: entertainment


text: Kulob Oblast (also Kulyab Oblast from Russian spelling) was an administrative subdivision in Tajikistan during the Soviet period (Tajik SSR). In 1992 it was merged with the Qurghonteppa Oblast to create Khatlon Province. The city of Kulob (Kulyab) was the capital of the oblast. The inhabitants of Kulob Oblast were referred to as Kulobis. Kulob oblast was a center for fighting in the first year of the civil war in Tajikistan. Many important figures in the government of Tajikistan originated from Kulob Oblast, including current president Emomalii Rahmon.


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People who are serious about Christian theology are usually not fans of books in the “self-help” genre. On the surface, the genre title itself goes against the grain of Christian teaching on personal growth. While there is some tension, there are books in this genre that do have merit and can be integrated into a Christian worldview.
Take for instance Charles Duhigg’s recent book The Power of Habit: Why We Do What We Do in Life and Business. The opening section focuses on the habits of the individual and their neurological basis. Here, readers are introduced to the Golden Rule of Habit Change: You can’t extinguish a bad habit, you can only change it. Habits, we find out, are driven by cravings. Figuring out what sparks a craving will make creating new habits and overwriting old habits easier.
Duhigg then widens the scope in the second and third parts of the book so we can see how successful organizations and movements utilize this knowledge. Profiles include the Tony Dungy era Tampa Bay Buccaneers, Procter & Gamble, Starbucks, Target, and even Saddleback Church. The profile of Rick Warren isn’t lengthy, but it is noteworthy. From even a secular point of view, habit formation seems connected to what we would call discipleship. In Duhigg’s estimation, Warren “gets it” when it comes to habits, and his church shows it.
Through it all, Duhigg drives home the point that habits can be changed if we understand how they work. As he explains it, habits are shaped around a cue, routine, and reward. Certain cues trigger cravings that lead us to follow a certain routine to get a certain reward. The routine is the habit that is changeable. Because it is tied to a cue and reward that might not be, that is why Duhigg thinks bad habits cannot be extinguished. Instead, they must be replaced. Nature abhors a vacuum, so habits must be rewired rather than removed.
From a Christian point of view, this fits well Paul’s emphasis to put off old behaviors and put on new ones. Because Paul doesn’t exactly lay out how to put off and put on, we should welcome the insights from someone who does. Duhigg provides readers with a powerful tool for understanding habits. When we pursue changing our habits in the power of the Spirit, it can lead to growth and Christ-like change. The result is not self-help, but using worldly wisdom for godly gain.
Charles Duhigg, The Power of Habit: Why We Do What We Do in Life and Business. New York: Random House, 2014. 416 pp. Paperback, $16.00.


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China bought more U.S. Treasury debt in September and total foreign holdings rose for a second straight month.
Total foreign holdings of Treasury debt increased 1.9 percent to $4.66 trillion, the Treasury Department said Wednesday.
China, the largest foreign holder, bought 1 percent more to bring its total holdings to $1.15 trillion. China had cut its purchases 3.1 percent in August.
The gains suggest foreign demand for U.S. debt remains strong, despite a prolonged debate this summer over increasing the nation's borrowing limit. Investors also don't appear to be concerned that Standard & Poor's downgraded the credit rating on long-term U.S. debt in August.
S&P said it lowered the U.S. credit rating because of politics that slowed the debt limit increase and not because it thought the U.S. couldn't pay its bills. U.S. government debt is still considered a safe investment. It has been in high demand as European debt crisis has intensified.
Japan, the second-largest buyer of Treasury debt, increased its holdings 2.2 percent to $956.8 billion. Britain, the third-largest holder, boosted its holdings 6.1 percent to $421.6 billion.
The 1.9 percent rise in overall holdings followed a 2 percent increase in August. Those two gains came after small declines of 0.4 percent July and 0.3 percent in June. Those declines had been the first overall declines since April 2009.
Net purchases of long-term securities, a category that includes not only U.S. government debt but also bonds sold by U.S. companies, increased by $68.6 billion. That's the biggest gain since November 2010.