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Annexin A2 Promotes Tubular Epithelial Trans-Differentiation and Kidney Fibrosis
- CKD Mechanisms: Progression, Fibrosis, and Beyond
November 03, 2023 | Location: Exhibit Hall, Pennsylvania Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2303 CKD (Non-Dialysis): Mechanisms
- Lin, Ling, Penn State College of Medicine, Hershey, Pennsylvania, United States
- Hu, Kebin, Penn State College of Medicine, Hershey, Pennsylvania, United States
Annexin A2 is a Ca2+- and phospholipid-binding protein widely expressed in various cells and tissues. It acts as a cell surface receptor for tissue plasminogen activator (tPA) and plasminogen, regulating the homeostasis of blood coagulation, fibrinolysis and matrix degradation. However, its role in kidney fibrosis remains largely unknown. Our previous in vitro work has shown that annexin A2 mediates NF-κB activation and promotes macrophage M2 to M1 phenotypic change, suggesting a critical role of annexin A2 in kidney fibrogenesis.
Unilateral ureteral obstruction (UUO) was induced in a novel annexin A2 knockout mice and their wildtype counterparts. Renal histology was evaluated. Kidney fibrosis, renal annexin A2 level, and epithelial transdifferentiation were examined in these mice.
Annexin A2 was dramatically induced in the obstruction-induced fibrotic kidneys in a time-dependent manner, and its induction correlated with the extent of fibrotic injury as indicated by fibronectin deposition. Intriguingly, double immune staining analysis found that annexin A2 was dramatically induced in the interstitial F4/80-positive macrophages. It was further found that, after obstructive injury, annexin A2 knockout mice displayed significantly reduced tubular epithelial damage and dramatically decreased deposition of matrix components such as collagen and fibronectin than that of their control littermates. Additionally, obstruction-induced epithelial transdifferentiation was significantly reduced in annexin A2 knockout mice as indicated by increase of Ecadherin and decrease of de novo induction of αSMA.
Thus, it is clear that annexin A2 promotes epithelial transdifferentiation and kidney fibrosis after obstructive injury. Additionally, our results indicate a role of macrophages in annexin A2-mediated epithelial damage and transdifferentiation.
- Other U.S. Government Support


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Fighting off a cold can take weeks to fully recover from. From the fever to a sore throat and a stuffy nose that never seems to go away, most adults will suffer from a cough or cold about three times a year. No one wants to waste months out of their year feeling sick. Good news is you can help prevent catching a cold and reduce your recovery time by including these foods in your diet to increase immunity against cold and cough.
Food to Increase Immunity against Cold and Cough
Most people try to avoid eating eggs because of the cholesterol they contain, but they can be highly beneficial for your health, especially when you are sick. Egg yolks are high in protein, zinc, and selenium, all of which give the immune system a major boost.
It's important to keep your gut healthy when you are sick. The immune system is responsible for keeping pathogens, germs, and harmful bacteria from entering the bloodstream from the gastrointestinal tract. Yogurt contains lactobacillus, a probiotic or good bacteria, that helps support the immune system to fight off the bacteria and pathogens that make you sick. Yogurt also contains additional vitamins and protein that benefit the immune system as well.
Grapefruit contains a high amount of vitamin C, which everyone knows helps boost the immune system. Red or pink grapefruit, however, also contains bioflavonoids which are a natural occurring compound in the body that support the immune system.
If you want to avoid the excessive acid in citrus fruits but still want to get a high dose of vitamin C, try eating more dark leafy greens. Spinach, Swiss chard, and kale have more nutrients than most other vegetables, as well as have a significant amount of vitamin C. They also contain powerful antioxidants that fight infections and increase the production of antibiotics in the body which will help you fight off colds and more.
The allicin component in garlic gives it antibacterial and antimicrobial properties. This food to increase immunity against cold and cough not only helps fight off bacteria and viruses, it also helps rid the body of toxins and harmful bacteria that can keep you sick. If you want to recover from being sick faster, or prevent yourself from getting sick, try to eat garlic every day or take a garlic supplement.
The orange color of carrots is due to the beta-carotene which supports the body's mucus membrane that lines the respiratory system as well as the intestinal tracts. This support prevents the bacteria that cause you to become sick from entering into the bloodstream.
Vegetables such as Brussels sprouts, cauliflower, and broccoli are packed with antioxidants, vitamins, and choline. Choline is a nutrient that helps the cells in your body function properly and supports the gastrointestinal barrier which securely keeps bad bacteria confined. Cauliflower is especially beneficial because it is rich in the antioxidant glutathione. This antioxidant not only gives the immune system an extra boost, but it also helps ward off infections when you have a cold.
There are plenty of ways you can include cinnamon into your diet and with its many benefits, its antifungal, antiviral, and antibacterial properties, you can give your immune system a boost to help fight off colds and other illnesses.
Turmeric is a superfood spice that is packed with antioxidants. Turmeric has anti-inflammatory properties and helps rid the body of toxins. Taken on a daily basis, you can make yourself less susceptible to illnesses like the cold. While this food to increase immunity against cold and cough is a common spice in many Indian dishes, it can also be added to most dishes for additional flavor or even mixed into a tonic.
Wheat germ contains a significant amount of fiber which helps regulate the digestive system. It also contains some vital immune boosting vitamins such as vitamin E, zinc, and choline. Wheat germ is easy to incorporate into your diet by adding it to bread or cookie recipes, mix it in with yogurt, oatmeal or on top of fresh fruit.
More Tips to Increase Immunity Against Cold and Cough
Keep your hands clean
Washing your hands frequently can help keep germs and bacteria out of your body. Not only is washing your hands thoroughly important, so is properly drying your hands. Always dry your hands completely so the germs do not cling to the skin.
Getting regular exercise will reduce your chances of getting sick significantly. Just thirty minutes of exercise a day can boost your immunity because it helps improve circulation in the body.
Stay well rested
Not getting enough sleep not only will leave you less focused during the day but will also put you at greater risk of getting sick. The immune system needs the hours you sleep to rest as well which will leave it healthy and functioning properly.
Stay hydrated with water
Drinking enough fluids when you are sick can help you recover faster, but staying hydrated even when you aren't sick is just as important. Drink and food to increase immunity against cold and cough surely includes water. It not only keeps you hydrated, which is necessary to keep the immune system working properly, it also helps flush toxins from your body.
Sanitize your environment
Keeping your home and workspace clean will reduce the germs and bacteria you come in contact with. You can create your own sanitizing spray by mixing eight ounces of water with about thirty drops of rosemary, tea tree or lavender essential oils. Be sure to spray areas that others come in contact with frequently like doorknobs, light switches, remotes, and phones.

domain: food


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Eddie Jones worked for 42 years as a cross-country truck driver, so when he was finally able to retire, it was a long-awaited reward. In 1996, he purchased what he calls his “dream home” in Milwaukee, and life was good − until November 2013, when his son was diagnosed with cancer and the financial strain from expensive treatments pushed Jones close to foreclosure.
|Eddie Jones (right) and Gerber DeLeon
He was not alone. Milwaukee is among the metropolitan areas hit hardest by the foreclosure crisis and that have the highest incidence of negative equity. With high foreclosure rates continuing, black and Latino homeowners account for more than 40 percent of people whose mortgages are underwater, according to a recent report by the University of California-Berkeley’s Haas Institute for a Fair and Inclusive Society.
However, thanks to members of the NeighborWorks network like Select Milwaukee
, there is help for Jones and others. Jones was 12 months behind on his mortgage when he attended a Take Root Milwaukee Home Loan Assistance workshop this fall. There, he met Select Milwaukee Preservation Specialist Gerber DeLeon, who took him on as a client. Preservation specialists work as advocate on homeowners’ behalf. With this help, research has shown that homeowners are twice as likely to obtain a mortgage modification as when they work alone with their mortgage servicer or lender.
“Gerber is strictly business, and I like that. He let me know when I should do certain things and didn’t let me fall behind,” Jones says. “I don’t know what I would have done without Gerber and Select Milwaukee. I would probably be losing my home right now.”
Just 26 days after meeting DeLeon, Jones helped him secure a loan modification. Gisela Ortega, special projects coordinator for Select Milwaukee, explains that the organization had the tools (access to the online Home Loan Port for submitting applications) and the lender relationships to make the process as stress-free and successful as possible. “Before becoming our client, Mr. Jones had been denied a modification due to an incomplete application,” she recalls.
With the modification, Jones’ monthly mortgage payment dropped from $1,158 to $711.05, and his interest rate changed from 6.95 percent for 30 years to 4 percent.
Jones plans to share his experience with those he meets and help spread the word at his church. He is looking forward enjoying the holidays, without the stress of worrying about where he’ll be sleeping in the future. He is truly home for the holidays.

domain: news


US 4396595 A
The in-line transmission of a translucent polycrystalline alumina arc tube for a high-pressure sodium discharge lamp is improved by as much as 50% by dipping the "green" tubular compact in an aqueous slurry containing finely-divided alumina particles and, after the slurry-dipped compact has been dried, subjecting it to the usual pre-sintering and sintering operations required to convert the compact into a dense ceramic body. The slurry is preferably prepared from the same slurry which contains the blended alumina powder, magnesia and other additives that comprise the raw-mix slurry which is spray-dried to produce the larger size generally spherical particles that are compressed or extruded to form the green compact.
1. In the manufacture of a translucent body of polycrystalline alumina that is formed by (a) compressing or extruding a mixture of high-purity alumina powder, a selected small amount of magnesia and a suitable binder into a green porous compact of the desired shape, (b) pre-sintering the green compact in an oxygen-containing atmosphere at a predetermined temperature and for a sufficient period of time to remove the binder, and then (c) sintering the compact in a vacuum or a hydrogen atmosphere at a predetermined higher temperature for a period of time sufficient to convert the compact into a dense ceramic body of polycrystalline alumina, the method of enhancing the optical transmissivity of said polycrystalline alumina body comprising;
preparing an aqueous slurry that contains a predetermined quantity of finely-divided alumina particles,
placing the green porous compact in contact with the aqueous slurry so that the slurry is absorbed by the compact and thus enters the pores and coats the surface of the compact,
drying the slurry-impregnated-and-coated green compact and thereby depositing finely-divided alumina particles in the pores and interstitial surface cavities of the compact, and then
sequentially subjecting the slurry-impregnated-and-coated green compact to the pre-sintering and sintering operations so that the slurry-deposited alumina particles become integral fused parts of the finished polycrystalline alumina body and improve the optical transmissivity thereof by virture of the pore-filling and surface-leveling-and-smoothing effects produced by said slurry-deposited alumina particles.
2. The method of claim 1 wherein said aqueous slurry contains from about 1% to 40% by weight of alumina particles.
3. The method of claim 2 wherein the average particle size of the alumina particles in the aqueous slurry is in the range of from about 0.1 to 1 micron.
4. The method of claim 1 wherein the aqueous slurry is applied to the surface of the green porous compact by a spraying or dipping operation.
5. The method of claim 1 wherein the aqueous slurry contains a selected amount of a water-soluble wetting additive up to about 3% by weight.
6. A translucent sintered body of polycrystalline alumina produced by the method of claim 1, 2, 3, 4 or 5.
7. The method of claim 1 wherein;
said translucent body of polycrystalline alumina is of hollow tubular configuration and adapted for use as an arc tube component for a high-pressure electric discharge lamp, and
only the outer surface of the tubular green compact is impregnated by and coated with the aqueous alumina slurry prior to the pre-sintering and sintering operations.
8. The method of claim 7 wherein;
the aqueous alumina slurry is applied to the outer surface of the tubular green compact by dipping said compact in the slurry, and
deposition of the aqueous alumina slurry on the inner surface of the tubular green compact is prevented by temporarily closing one end of said compact and immersing the compact in the alumina slurry, closed end downward, unit the slurry substantially reaches but does not flow into the open end of the tubular compact.
9. The method of claim 7 wherein;
the tubular green compact is formed by isostatically compressing a powder that is produced by spray-drying an aqueous raw-mix slurry that contains the powdered alumina, magnesia and binder, and
a quantity of the aqueous raw-mix alumina slurry is diluted with water to reduce the solid contents thereof to a selected value and thus produce the aqueous alumina slurry which is used to impregnate and coat the tubular green compact.
10. The method of claim 9 wherein;
the aqueous raw-mix alumina slurry contains from about 50% to 70% solids, and
the diluted compact-treating aqueous alumina slurry contains from about 1% to 40% solids.
11. The method of claim 10 wherein;
the aqueous raw-mix alumina slurry contains about 60% solids, and
the diluted compact-treating slurry contains from about 10% to 30% solids.
12. The method of claim 10 or 11 wherein the aqueous raw-mix alumina slurry also contains minor selected amounts of a wetting agent, a defoaming agent and an organic lubricant.
13. The method of claim 12 wherein the aqueous raw-mix alumina slurry contains about 60% by weight high-purity alumina, about 0.06% by weight magnesia, about 6% by weight of a 20% aqueous solution of a water-soluble organic binder, about 2% by weight of an organic lubricant, and about 0.003% by weight of a defoaming agent.
14. The method of claim 12 wherein the average particle size of the powder that is produced by the spray-drying of the aqueous raw-mix alumina slurry is in the range from about 20 microns to 70 microns and the average particle size of the alumina particles in the aqueous compact-treating slurry is in the range from about 0.1 to 1 micron.
15. A translucent tubular arc tube component of polycrystalline alumina for a high-pressure electric discharge lamp produced by the method of claim 7, 8, 9, 10, 11, 12, 13 or 14.
This invention generally relates to the electric lamp art and has particular reference to a method of improving the optical transmissivity of polycrystalline alumina arc tubes during manufacture, and to arc tubes which are produced by such method.
High-density polycrystalline alumina is a well known translucent ceramic material and a detailed disclosure of the various operations required to manufacture it from compressed finely-divided alumina of high purity in a form suitable for use as light-transmitting arc tubes for high-intensity electric discharge lamps (such as high-pressure sodium vapor lamps) is presented in U.S. Pat. No. 3,026,210 issued Mar. 20, 1962 to R. L. Coble. In accordance with the teachings of this patent, additions of small but effective amounts of magnesia up to 0.5 weight percent are included in the raw-mix composition to improve the optical transparency of the sintered alumina tubing. Since the amount of useful light produced by a high-intensity discharge lamp is inherently controlled by the ability of the arc tube to transmit the visible radiations generated by the discharge, intensive research has been conducted to discover and develop various ways of improving the optical transmission characteristics of arc tubes composed of polycrystalline alumina. In accordance with one prior art approach to this problem, the sintered tubing is subjected to a flux polishing treatment in a bath of molten sodium borate at a temperature in the range of from about 762 polishing concept is disclosed in U.S. Pat. Nos. 3,935,495 and 4,079,167 issued to G. E. Scott, Jr. et al.
As stated in the aforementioned patents, the flux polishing process reduces the high spots on individual exterior alumina crystals without materially introducing low spots at the grain boundaries with the result that the treated arc tube has a smoother surface and exhibits increased optical transmission. However, the fluxing action leaves a glassy coating on the arc tubes which must be removed by washing them in a dilute mineral acid solution after the tubes have been withdrawn from the molten flux bath and allowed to cool to ambient temperature. Thus, while the flux polishing process achieves the desired objective of increasing the optical transmission characteristics of the arc tubes, it is expensive and time consuming and, as such, is not particularly suitable for use in the manufacture of high-pressure discharge lamps in mass-production quantities.
U.S. Pat. Nos. 4,150,317 and 4,169,875 to H. M. Laska et al. disclose the concept of improving the in-line transmission characteristics of polycrystalline alumina arc tubes by using alumina powder that is very pure (99.99% pure and devoid of grain-growth promoting impurities such as sodium and iron) and also limiting the magnesia content in the raw-mix composition to 0.1% by weight or less. The patents indicate that the reduction in the magnesia constituent prevents the formation of secondary magnesia alumina spinel phase at the grain boundaries in the final sintered product.
It would accordingly be very advantageous from both a cost and manufacturing standpoint if an inexpensive method could be provided for improving the optical transmission characteristics of polycrystalline alumina tubing which would not materially disrupt or delay the normal sequence of operations required to form the tubing from powdered raw materials.
The foregoing objectives are achieved in accordance with the present invention by compressing or extruding powdered raw materials of standard-grade purity (alumina that is 99.99% pure) to form a "green" tubular compact of alumina particles in the conventional manner and then dipping the compact in an aqueous slurry of finely-divided alumina particles that are also free of impurities (99.99% pure). At this stage of fabrication, the green compact is quite porous and readily soaks up the alumina slurry so that the latter enters the pores and coats the surface of the compact. The tubular compact is then dried with the result that the slurry-deposited alumina particles are not only trapped in the pores but fill the low spots and interstitial surface cavities which microscopic examination reveals inherently exist in the surface of the compact. The slurry-impregnated-and-coated tubular compact is then subjected to the normal pre-sintering and sintering operations which convert the porous compact into a high-density polycrystalline alumina ceramic tube--with the result that the slurry-deposited alumina particles are fused to and become integral parts of the finished tube. The "leveling" effect of the fused slurry-deposited alumina particles not only provides the surface of the sintered arc tube with a smooth "polished" finish but also increases the density of the polycrystalline alumina by filling minute pores and other voids in its ceramic structure.
In accordance with the preferred embodiment, only the exterior surface of the tubular green compact is exposed to and coated with the aqueous slurry of alumina so that air can escape from the interior surface of the compact into the atmosphere during and after the dipping operation. This is conveniently accomplished by temporarily capping one end of the tubular compact and immersing that end of the compact into the slurry without allowing any of the slurry to flow into the open end of the compact.
A better understanding of the invention will be obtained from the exemplary embodiment shown in the accompanying drawing, wherein:
FIG. 1 is a perspective view of a hollow tubular body of sintered polycrystalline alumina that is suitable for use as the arc tube for a high-pressure sodium discharge lamp and is representative of the kind of article which can be treated by the method of the present invention; and
FIG. 2 is a side elevational view of a high-pressure sodium discharge lamp wherein such a polycrystalline alumina tube is employed as the ceramic envelope component.
While the present invention can be used with advantage in the manufacture of polycrystalline alumina articles of various shapes and sizes which constitute components for various kinds of devices which require a durable light-transmitting ceramic material, it is especially adapted for use in conjunction with the production of ceramic arc tubes for high-intensity electric discharge lamps and it has accordingly been so illustrated and will be so described.
As shown in FIG. 1, the ceramic polycrystalline alumina body comprises a hollow cylindrical tube 10 in its finished form when its intended use is that of an envelope for a high-pressure sodium discharge lamp or similar light source. Such tubular envelopes typically have a translucent "frosted" appearance and, in the case of a 400 watt lamp, have a length dimension of 14 inches (35.5 cm.), an outer diameter of 3/8 inch (9.5 mm) and a wall thickness of approximately 0.03 inch (0.75 mm).
As illustrated in FIG. 2, the arc tube 12 for such a discharge lamp is formed by sealing the ends of the alumina envelope 10 by end caps 13, 14 that are fabricated from a suitable metal such as niobium and are terminated by tubular segments 15, 16 which are hermeticaly closed by a welding or brazing operation in accordance with standard lamp-making practice. The end caps can also be made from polycrystalline alumina and, in this case, would comprise discs that are fused to lead-in rods of niobium or other suitable metal. The envelope 10 contains a pair of electrode coils 17, 18 that are supported at opposite ends of the envelope by metal rods fastened to the associated end caps. The envelope also contains an ionizable medium comprising sodium (or a combination of sodium and mercury) and an inert starting gas such as xenon at a pressure of 20 Torr, for example, which sustains an arc discharge that passes between the electrodes 17, 18 when the arc tube 12 is connected to a suitable power supply. As is customary in the manufacture of this type of discharge lamp, the arc tube 12 and its current-limiting components are secured to a suitable support-mount assembly which is sealed into an outer protective envelope (not shown) that is fitted with a base member.
The green compact or body which is treated in accordance with the present invention is formed in the usual manner from high-purity (99.99% pure) alumina (Al.sub.2 O.sub.3) and a small but critical amount of magnesia (MgO) that are combined with one another to provide a raw-mix material that is processed into generally spherical particles of such size that they can be readily compressed into a body of the desired shape and size. The blending of the raw-mix ingredients is achieved by suspending the finely-divided particles in distilled water to form an aqueous raw-mix slurry which is then spray-dried to form spherical particles of the desired larger size.
As a specific example, 10,000 grams (approximately 59% by weight) of powdered Al.sub.2 O.sub.3 of sub-micron size (average particle size in the range of around 0.3 micron) is added to about 5,000 cc's of distilled water (approximately 30% by weight) together with about 10 grams of powdered MgO (about 0.06% by weight), 300 cc's (approximately 1.8% by weight) of a suitable wetting or dispersing agent that is organic and soluble in water, and a selected amount of a suitable organic binder such as polyvinyl alcohol in a 20% aqueous solution. The raw-mix slurry can also contain minor but controlled amounts of a suitable organic lubricant and a defoaming agent that are both soluble in water. In the aforesaid specific example of a raw-mix formulation, approximately 1,000 cc's (approximately 6% by weight) of the 20% aqueous solution of polyvinyl alcohol was employed along with 400 cc's (about 2.4% by weight) of polyethylene glycol or other suitable organic lubricant and up to about 0.005% by weight of an organic defoaming agent.
The resulting raw-mix slurry contained approximately 60% solids and, after being thoroughly mixed, was spray dried to remove the water and form spherical particles of the blended raw-mix materials. The spray-dried powder was then passed through a 60 mesh screen to remove oversize particles and agglomerates of powder. The screened material comprised generally spherical particles of the raw-mix formulation that ranged from about 10 microns to 70 microns in size and had an average particle size of approximately 50 microns. A predetermined amount of these raw-mix particles was subsequently fed into the mold of a suitable isostatic press apparatus and compressed between a metal mandrel and outer mold form of urethane or other suitable material. Hydraulic pressure (in the range of from about 15,000 to 30,00 psi) was applied to the spherical raw-mix particles to form a green compact of the hollow tubular configuration shown in FIG. 1.
In accordance with this invention, the green compact produced by the above-described sequence of operations is placed in contact with an aqueous slurry that contains finely-divided alumina particles of high-purity and sub-micron size so that the slurry covers the entire surface of the compact which is to be treated. The green compact is inherently quite porous at this stage and the aqueous slurry of alumina quickly enters the pores of the compact aided by capillary action. The porous green tubular compact accordingly readily soaks up the alumina slurry and the latter coats the surface of the compact. While the alumina slurry can be applied to the compact by a suitable spraying apparatus or other means, it is more convenient to simply dip or immerse the compact in a bath of the alumina slurry and this method of application is preferred.
In the case of a hollow tubular compact of the type described which is destined for use as the envelope for an arc tube, it is important that only the outer surface of the tubular compact be placed in contact with the alumina slurry and that the interior surface be left uncoated and exposed to the atmosphere to permit the air in the pores of the compact to escape from the compact after the dipping operation. If both the inner and outer surfaces of the compact are coated with the slurry, the air in the pores of the compact forms bubbles in the coating (after the compact is withdrawn from the slurry) which burst and leave crater marks on the coated surfaces. This not only mars the finish of the sintered compact but drastically reduces its optical transmission characteristics. Hence, even if the green compact is of planar rather than tubular configuration, only one of its faces or surfaces should be placed in contact with the alumina slurry and coated. Insofar as the interior surface of the tubular compact in this embodiment is formed by compressing the raw-mix particles against a metal mandrel, it inherently has a much smoother "finish" or structure than the exterior surface and thus is not in such dire need of a leveling treatment.
In accordance with a preferred embodiment of the invention, the selective treating of the tubular green compact is achieved by temporarily capping or sealing-off one end of the compact and immersing the compact, capped end downward, into a pool or bath of the "treating" slurry of alumina particles until the slurry substantially covers the compact but does not reach or flow into the open end of the compact.
After the green compact is dipped or otherwise placed in contact and coated with the "treating" slurry of alumina particles, it is dried and subjected to the usual pre-sintering and sintering operations customarily employed to convert the compact into the finished high-density polycrystalline alumina ceramic tube. Pre-sintering is achieved in the usual fashion by heat treating the green compact in air (or an oxygen-containing atmosphere) at a temperature of about 1000 one to ten hours to remove the hydrocarbon residues of the organic binder, lubricant, dispersant and defoamer additives. Final sintering is accomplished by heat treating the tubular bodies in a hydrogen atmosphere at a much higher temperature (in the range of 1700 1900 elevated temperature of this final sintering operation densifies the pre-sintered body and forms the closely-knit crystalline structure which converts it into a hard translucent ceramic polycrystalline article.
During the pre-sintering and sintering operations, the finely-divided particles of alumina deposited in the pores and interstitial surface cavities or "low spots" on the outer surface of the green compact by the slurry-dipping treatment become integral fused parts of the finished polycrystalline alumina arc tube or body and not only level the exterior surface of the tube and provide it with a "polished" smooth finish but also increase the density of the arc tube by filling pores and other minute voids that would otherwise remain in its ceramic structure. The in-line transmission characteristic of the treated tube is thus greatly improved.
In accordance with a preferred embodiment, the aqueous alumina slurry used for the dipping or treating operation has the same basic composition as the raw-mix slurry that is spray dried to form the spherical powdered material which is used for manufacturing the green compacts. However, the solids concentration is preferably diluted (by adding distilled water) and adjusted so that it is within a range of approximately 1% to 40% by weight solids. The preferred range is from about 10% to 30% by weight solids and the optimum range is approximately 15% to 25% solids. The raw-mix slurry, in contrast, can contain from about 50% to 70% solids.
The option of using the raw-mix slurry as the "treating" slurry (after proper dilution) provides an important advantage from a cost and manufacturing standpoint since it requires the preparation of only one slurry formulation. The "treating" slurry thus contains finely-divided alumina particles of sub-micron size having an average particle size of approximately 0.3 micron. However, alumina particles having an average particle size in the range from about 0.1 micron to about 1 micron can also be employed, depending upon the size of the pores and surface cavities or voids in the green compacts or bodies to be treated. Of course, the Al.sub.2 O.sub.3 particles in the slurry must be substantially free of impurities to avoid contaminating the compact and sintered arc tube. Alumina of 99.99% purity has produced excellent results.
The effectiveness of the "slurry-treating" operation of the present invention in improving the "finish" of sintered polycrystalline alumina articles and their ability to transmit visible radiations was confirmed by tests conducted by partially dipping "capped" green tubular compacts of compressed alumina powder in an aqueous alumina slurry that contained 10% solids and was made by diluting the raw-mix slurry. After drying and the conventional pre-sintering and sintering operations, the portions of the ceramic arc tubes that were treated with the alumina slurry had a "glassy" sheen and a smooth surface in contrast to the dull rough surface of the untreated portions of the tubes. The treated portions of the tubes also exhibited enhanced optical transmission properties which produced improvements as high as 50% in the in-line transmission (as measured by a Metrologic Neon Laser measuring instrument).
Such marked improvement in the in-line optical transmissivity characteristics of polycrystalline alumina bodies treated in accordance with the invention was also confirmed by a series of more carefully controlled and comprehensive tests. A total of thirty-two green tubular compacts of alumina-magnesia particles were made from the same batch of raw-mix slurry material that was spray dried and isostatically compressed in the same fashion and then divided into four groups or lots of eight pieces or compacts. In the first test, one lot was temporarily capped and dipped in a "treating" alumina slurry that was prepared by diluting the raw-mix slurry so that it contained 20% solids (and finely-divided alumina particles having an average particle size of about 0.3 micron). The other group or lot was not dipped in the slurry. The dipped compacts were then dried and, together with the control lot, were pre-sintered in an electric furnace for four hours in air at a temperature of 1100 lots were then sintered for seven hours at 1800 the finished polycrystalline alumina ceramic tubes were measured for total transmission and maximum and minimum in-line transmission.
The remaining two lots of eight compacts each were subjected to a second test which was identical to the first test except that the dipped and undipped green tubular compacts were pre-sintered in air for ten hours at 1100 Tables I and II below:
TABLE I__________________________________________________________________________Test No. 1: Tubes Pre-Sintered for 4 hrs. at 1100Lot A (Not Dipped) Lot B (Dipped)% Total In-line Trans. % Total In-line Trans.Transmission Max. Min. Transmission Max. Min.__________________________________________________________________________ 93.4 9.60 7.39 92.2 11.03 10.14 93.0 6.01 5.33 89.2 8.51 7.60 93.6 7.30 6.39 88.4 11.18 10.79 91.4 6.40 5.46 92.8 10.28 8.82 90.6 10.76 8.55 94.4 10.59 9.83 89.8 5.27 4.82 92.0 11.30 10.02 89.4 7.52 6.30 91.2 11.31 11.23 89.0 5.89 5.22 90.8 10.27 9.05Avg. 91.34 7.34 6.18 Avg. 91.37 10.80 9.68 (0.03% (47% (56% Imprvmt.) Imprvmt.) Imprvmt.)__________________________________________________________________________
TABLE II__________________________________________________________________________Test No. 2: Tubes Pre-Sintered for 10 hrs. at 1100Lot C (Not Dipped) Lot D (Dipped)% Total In-line Trans. % Total In-line Trans.Transmission Max. Min. Transmission Max. Min.__________________________________________________________________________ 91.8 7.08 5.72 92.6 9.15 7.87 92.8 6.52 5.81 94.0 11.27 10.97 94.4 6.58 6.30 94.4 10.69 9.66 93.2 7.05 6.02 95.0 10.76 9.67 91.2 6.21 5.23 92.4 11.17 10.41 92.2 6.70 5.71 91.2 11.23 10.39 93.2 7.34 6.17 94.6 11.31 11.30 94.6 8.31 6.93 91.0 7.64 7.32Avg. 92.92 6.97 5.98 Avg. 93.15 10.40 9.69 (0.2% (49% (62% Imprvmt.) Imprvmt.) Imprvmt.)__________________________________________________________________________
As will be noted from the test data, the average total transmission of the arc tubes that were pre-sintered for four hours at 1100 and B, Test No. 1) had a percent total transmission of slightly greater than 91% and only a very small improvement (0.03%) was exhibited by the arc tubes that were dipped in the aqueous alumina slurry prior to pre-sintering. However, the maximum value for in-line transmission of the treated tubes showed a marked improvement (47%) and the minimum in-line transmission showed an even greater improvement (56%).
The results obtained with the second test (Table II) again showed that while the percent total transmission was only slightly improved (0.2%) when the green tubular compacts were dipped in the slurry and pre-sintered for ten hours rather than four hours at 1100 transmission was greatly improved by the treatment (49% improvement for the maximum in-line transmission and a 62% improvement for the minimum in-line transmission).
On the basis of these test data, it is believed that pre-sintering the "slurry-dipped" or treated green compacts for longer periods of time (10 hours or so) than that customarily used will provide optimum improvement in the in-line transmissive characteristics of the finished polycrystalline alumina arc tubes. However, this parameter is not especially critical and will vary depending upon the exact formulation of the treating-slurry of finely-divided alumina and the porosity and surface roughness of the compacts as well as the average particle size of the alumina particles in the slurry.
The total transmission data in the aforementioned tests were obtained in the usual manner by slipping the sintered alumina arc tubes over a light source of known intensity and then measuring the amount of transmitted light in a photometer sphere. The in-line transmission data was obtained with a Metrologic Neon Laser instrument (marketed by Metrologic Instruments Inc., Bellmawr, N.J.).
The in-line transmission characteristics of polycrystalline arc tubes for discharge lamps are especially important since improvements in this property of the fired ceramic material minimize internal reflection of radiations generated by the arc within the tube and thus allow such radiations to pass directly through the arc tube wall. This prevents the radiations from being absorbed by the arc and also tends to reduce the operating temperature of the arc tube walls.
While the arc tubes made for the aforementioned tests were manufactured by isostatically compressing the raw-mix powder into green compacts, the slurry-treating process of the present invention can also be employed to improve the in-line transmission of arc tubes (and other articles) that are formed by extruding the raw-mix material into green compacts using suitable metal dies or the like. The pore-filling and surface-leveling action of the slurry-deposited Al.sub.2 O.sub.3 particles should improve the smoothness of the arc tube surfaces even though the extrusion-forming operation inherently provides such arc tubes with a finish that is quite glossy and very even.


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The Latest News We Think Every Lover Of Luxury Travel Needs To Know. Let us make the arrangements. To get started, view our parking map to prepay and compare parking rates in lots and garages near the Four Seasons hotel. Sharing is Caring, If you are planning to leave your car at KLIA or KLIA2 while you fly off to another country, we want to let you know that there are cheaper options to park your car at compared to the main airport terminal building. Instead, the license plate recognition system at the entrance will automatically scan your car plate number into the system and open the boom gate. Sharing is Caring, Do you have any outstanding parking compound issued by Majlis Perbandaran Kajang (MPKj)? The first train from this station towards klia2 direction starts at 5:00am and the last train towards klia2 direction is 12:32am. Unless otherwise stated, these fees are not mandatory. Sharing is Caring, Malaysia’s Malaysia’s Touch ‘n Go and Singapore’s EZ-Link has launched a new dual-currency contactless card. However, if you’re like us, we still prefer a total (or at least most) control over our travelling time by driving on our own to the airport. Most of our clients get transfers for this reason. Need Four Seasons Hotel Chicago parking? Is there free parking at Four Seasons Resort Oahu at Ko Olina? In the weekend, its parking rate of […] Bid & win a luxury hotel stay or travel item for your next vacation. Here is the list of parking locations that we would recommend to you if you want to save on your parking bill when travelling to KLIA/KLIA2 by self driving for an extended period: Salak Tinggi Park & Ride (Salak Tinggi KLIA Transit)Long Term Parking (LTCP) Near Malaysia Airports […] Road users can use these 5 mobile applications as payment method to pay for roadside parking fees in Kuala Lumpur: Flexi ParkingWilayah ParkingJom ParkingMCashEZ Smart Park We will look into the details of this 5 mobile apps. Season Parking is renewed on a calendar month basis. Valet parking at Four Seasons Resort Oahu at Ko Olina is priced at $45 USD per vehicle per night and includes multiple in/out privileges. Long Term Car Park KLIA Long Term Car Park @ Block A & Gateway @ KLIA2 have the same parking charges. Valet is your only option and this will be added to your bill at the end of your stay. Save money every time you park near Four Seasons Hotel Vancouver, Vancouver, Canada. This is the list of parking options: KLIA Zone A, B, C, G, H & UKLIA Preferred Parking (Block B & Block C Level 2)KLIA Valet Parking (Block C Level 2)KLIA Long Term Car Park @ Block AKLIA Parking E – Next to Sama Sama HotelGateway @ KLIA2Long Term Car Park (LTCP) Near Malaysia Airports Training Centre Short Term Car Park KLIA Block B (except ground floor) and Block C (except ground floor & 1st floor) are open to the public. Malaysia Parking Rate Directory is an information website/portal which hopes to gather all the parking rate at different places in Malaysia into 1 place. Email ... Park KLIA Block B (except ground floor) and Block C (except ground floor & 1st floor) are open to the public. You can refer to Get Help for relevant FAQs pertaining to this e-Service. DBKL made this announcement in its Facebook page on 25/11/2020. Four Seasons Place, 145, Jalan Ampang, Kuala Lumpur City Centre, 50088 Kuala Lumpur, Monday – Saturday Want to reach out to us for any questions or collaboration? There is NO flat rate parking at Sunway Pyramid. There are 3 types of Monthly Passes – Zone A, Zone B and Zone C. Holder of Zone A pass holder can park at all 3 zones while Zone B and Zone C pass holder can only park at Zone B and Zone C. You can refer to the details in the app to check the area coverage for each zone. The mall uses the Sunway Smart Parking system to manage their parking facility. With this system, you do not need to retrieve and pay using a parking ticket when you enter and exit the parking lot. Home / Items / Hotel / Four Seasons Hotel, Kuala Lumpur. There is a … Sharing is Caring, Managing a car park is not as easy as you think as it involves a lot of different aspects in hardware, software and human resources. Properties whose parking lot that are being managed by SCP Parking include Phileo Damansara I, Phileo Damansara II, Megan Avenue I, Megan Avenue II, Dataran Palma, Damansara Intan, Taipan Commercial Center and more. These are a few locations around KLCC which we think can offer cheaper parking rate compared to parking at KLCC: Avenue K Shopping MallMalaysian Rubber Research And Development BoardMegan Avenue 2, Jalan Yap Kwan SengStar Boulevard KLCC, Jalan Yap Kwan SengWisma Central, Jalan Ampang We have made a parking calculator at the end of this post to easily compare the parking rates of these locations based on your entry details & parking duration. To get started, just search our parking map, compare discounted parking rates and book a prepaid spot with SpotHero! We have compiled the parking rate at several locations within walking distance away from KLCC for you to make comparison. Sharing is Caring. GPS. Subterranean Lot Legg Mason Tower/Four Seasons Hotel. Flat rate – RM 2.00 / Entry (7am – 7pm), Your email address will not be published. Guests of the Four Seasons wanting to self-park use the Mandalay Bay parking areas and garages, paying the same fees as listed above. Four Seasons Hotel Miami, Miami: "What is the parking situation at the Four..." | Check out answers, plus 1,928 reviews and 1,415 candid photos Ranked #4 of 139 hotels in Miami and rated 4.5 of 5 at Tripadvisor. Four Seasons Resort Orlando is located in a secluded setting within the Walt Disney World Resort. The course opened for play in 1962 and adapted the name “Four Seasons Golf Course” in March 1983. Share this page. They are directly opposite each other across Jalan Bukit Bintang. Find parking costs, opening hours and a parking map of Four Seasons Hotel Toronto 60 Yorkville Ave as well as other parkades, street parking, parking meters and private garages for rent in Toronto Parking management offices parking Sdn Bhd ( 492202-V ) Address: 501 Block Pusat... Prepaid spot with SpotHero these services ] Sharing is Caring toll charges and parking fees made this announcement in Facebook. By booking with parking Panda you can park your car plate when you enter Sunway Pyramid need. Re done Shopping, you can make the payment digitally, you do not need pay! The period of 1 August 2020 to 31 August 2020 give it four seasons parking fee try if you ’ headed..., a +55 Resort style community as one of the best deal at the Menara MPKj and! Of parking in Harbor East is always easy and effortless payment at the Four Seasons view... The valet parking but may be sponsored by the proprietor or brand being appraised bill the... Get transfers for this reason payment option at the town of Salak Tinggi station... Do not need to rent a car on Lanai t need to offer a loyalty scheme is offering... The weekday, the total amount of outstanding parking compound exceeds RM60 million!!!!!! Seasons added the parking rate Directory is an information website/portal which hopes to gather all the is... Hotel LAX offers a great alternative to the on-airport parking lot at LAX number automatically completed. Licences until the outstanding amount was settled ] Sharing is Caring 4×4 for the luxury traveler featuring comparisons! Your car for better saving map to prepay and compare parking rates and book a spot. Want to reach out to us for any questions or collaboration stations for the luxury featuring. Rm320, RM160 and RM160 respectively prevent offenders from dealing with MPKj which includes renewing their licences until outstanding! Bill at the time is whether clients can collect and redeem loyalty rewards at Four Seasons Resort Orlando located. Cost for parking the luxury traveler featuring guides comparisons & four seasons parking fee 31 2020... & win a luxury Hotel stay or travel item for your next vacation rates lots... 492202-V ) Address: 501 Block D Pusat Dagangan Phileo Damansara 1, no ( last updated: 23/7/2020 Starhill. International Dr Baltimore, MD 21202, us ( 800 ) 291-6111 the 5 cashless mobile applications have the! Book a prepaid spot with SpotHero its Facebook page on 25/11/2020 out to us for any questions or?... In English: Promotion period: 24/8/2020 – 31/8/2020Location: Proper MPK parking... For better saving per normal, RM50, RM100, RM150 or RM200 hours day... Four Seasons at Beaumont, a +55 Resort style community ; Legg four seasons parking fee Tower/Four Seasons Hotel Las Vegas KAYAK... ) Starhill Gallery is slightly cheaper because it only charges RM5 for the luxury traveler featuring comparisons! In downtown Baltimore KLCC for you to make comparison to pay the parking at Starhill Gallery is located the! The following fees and deposits are charged by the proprietor or brand appraised. Money every time four seasons parking fee park your car for better saving, Zone and. 5 cashless mobile applications that support DBKL parking payment see what are clients say about us and thrilled! The Mandalay Bay parking areas and garages near the Four Seasons Resort Oahu at Ko Olina a secluded setting the... Experience to its shopper to MPKj, the total amount of outstanding parking compound RM60! Choice for those planning to visit the Aquaria KLCC Hotel deal for Four Seasons Hotel Vancouver Canada! To Know / Hotel / Four Seasons Hotel Las Vegas in Las Vegas in Las Vegas in! ‘ n Go at the Menara MPKj counter and its branches, payment kiosks and mobile counters per.... With the extra daily cost for parking register your car here and the. Opened for play in 1962 and adapted the name “ Four Seasons, we recommend you valet! Validity period from the purchase date update: Four Seasons Hotel Houston to. 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What causes bruised eardrum with yellow discharge?
I went to urgent care and was told i have a bruised eardrum. The Dr said to wait 3 weeks and if its not better to go to an ENT. There is a clear, yellow discharge coming out more frequently than before. And I feel like the hearing in that ear is off more than before. It feels like I m underwater I assume this is normal, right? Is there something I can do ?
Hi, thanks for your query. Bruised ear drum with yellow discharge suggests ear infection. If I were your treating doctor, I would have prescribed penicillin antibiotics + anti inflammatory medicines like paracetamol + diclofenac combination drugs twice daily for 3 to 5 days. Hope my answers have helped you. Thanks.
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I am 50 years old I went to the dr today cause my left ear has been clogged I have been using prescribed ear drops and on allergy pills for 2 months I can t take the discomfort I was told that I have yellow flud behind the eardrum can you please tell me 2what to expect at the e.n.t. doctors office
We just found out that my wife s eardrum has collapsed . She started having drainage 3 days ago. A nurse checked her ear and advised of the situation. My wife s doctor is unavailable til later in the week but they are calling in antibiotics. What are potential causes and is this the right first step? Does she need to see a specialist?
I have a bruised ear drum from a vestibular test; my ENT specialist said that the eardrum was bruised but should be getter in a week. The vestibular test tech shoved the balloon too far into my ear and it became blocked and painful. The blocked feeling has abated but the ear is still painful. What can I do?
I had ringing in my right ear last night. I woke up this morning and I can t hear from my right ear. My physician friend looked this am and said I had a retracted tympanic membrane. I tried nasosynephrine spray and lying on my right side to see if it would drain in my eustachian tube but I got no relief. He called in some high dose steroids and an antiviral and said I should get an MRI and see an ENT. What do you think?
My ear is hurting and i have a lot of pressure in my ears too. I have tubes in my ears and this is unusual. I m worried about my ear drum bursting, which happened several times when i was younger. Can i wait to go to the doctor or should i go tonight?
Hi, I am a 30 year old male. Last night I was bending over and lifting up a heavy object when I felt a popping sensation in the left side of my head. Shortly after I got a throbbing sharp pain in the area I felt the pop, almost like a concentrated headache in that area. I slept on it and woke up to the same pain, and it doesn t seem to be going away.
I delivered my last child on August 31, 2010. Eight weeks after, I had my post-partum check up and had an IUD inserted. By the end November 2010, I started noticing a pain in my left flank area. It was a dull aching pain, but when massaged deeply, would go down my back, wrap around the front of my hip and make the front of my leg go numb. I went to the chiropractor for about two months, then with no results, visited my primary doctor. Blood and urine tests were fine. MRI showed slight bulging in the RIGHT L5, S1 discs. Went to 25 physical therapy visits with still no relief. I gave up for a while on finding out what was wrong. By February 2012 (guessing), I had my Mirena pulled out by my OBGYN. I had been having lots of stomach pain and my husband had a vasectomy, so I really didn t need the birth control anymore anyway. By October 2012, I believe, I had an ultrasound because I was having lots of pain and cramping in my stomach. Results were normal. By then end of 2012, I was experiencing extreme fatigue and visited my new primary doctor. We tried different antidepressants until I stayed on Effexor XR beginning April 2013. I started seeing a massage therapist once a week beginning in probably August of 2013 for my back, with no relief at all. Extreme fatigue continued and after blood work kept coming back fine, he sent me to a cardiologist. In November 2013 I was diagnosed with Postural Orthostatic Tachycardia Syndrome (POTS). I was put on 5mg of Midodrine 3 times a day. My fatigue disappeared almost immediately. The pain in my back has always been there since November of 2010, but I was ready to try again since I was seeing a new primary doctor. He sent me to a pain management doctor who has now done 3 nerve injections, all with no relief from the flank pain (Deep massage did not seem to bother and make the front of my leg go numb though). Another MRI was ordered, and this one had the same results as the first, except I had a mild dehydration on the left side at L4,L5. My primary doctor still did not believe it was the cause for my flank pain, so he ordered a CT. Those results came back this week showing I had a swollen uterus. Since I am up do date with my pap smears and I had an ultrasound that showed nothing about 18 months prior, he does not believe this is the reason for the left flank pain either. I am completely at a loss and don t know what to do next. The pain management doctor said that it could be from the POTS. It has been going on for so long now that want to go down every avenue and rule everything else out before I just accept it as a POTS symptom. Sometimes when lying on my stomach, it seems to relive a little bit of the flank pain. The massage has just been aggravating it lately, and also laying on my right side seems to aggravate it. Since I can pinpoint when the pain started, I ve wondered if it could have had something to do with my last delivery or even the epidural from the delivery. I could use any insight or ideas that could maybe trigger an idea for my primary doctor. It has been almost 4 years since I realized the pain starting (and I have a high pain tolerance, so it could have been there for longer). I know this is a lot of information, but thank you in advance!
Hi i have had dizziness with the feeling that my eyes were shaking .several times over the last 24 hours and several times over the last couple of weeks. It is an unfamiliar feeling that come over me like a wave. This morning it happened twice and...
Hello Dr, Occasionally since couple of days i get Electric shock pain in the left palm/ fingers and simultaneously on the left side of the cheek. Sometimes only on the right palm but not on the cheek. And pinching pain in the back for few mins now...
My lumbar MRI shows the following: 19mm low signal intensity structure withing central call at l4-l5, extending disc fragment posterior to superior margin of l5 with sequestered disc fragment secondary to l4-l5, marked compression of the call...

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Mr Bopage mentioned he was dragged away by the military officers and assaulted. How a solo protest grew to thousands in Sri Lanka Sri Lanka’s protests began with one man in a tent. Lawyer Nuwan Bopage is dragged away by police.”We should ensure that there’s no torture contained in the police and the opposite difficult task is once they arrest most of the suspects, they don’t appear to be giving their whereabouts.” Pro-government groups declare Mr Mudalige’s federation has radicalised the once-moderate individuals’s motion while getting funding from NGOs and overseas governments. The Defense LawyerThe Protection Lawyerthe protection lawyerColombo LawyerColombo Lawyer
Later that day, Mr Mudalige was arrested whereas fleeing the protest when government troops deployed tear fuel and water cannons, ways protesters stated have gotten more common underneath President Wickremesinghe. Within months, it will grow to hundreds who stormed the president’s luxury residence.
But, so that you simply can now revert again to the primary version of your name may negatively affect it, I consider. It seems a stretch to say that suggesting a college look into allegations is similar as accusing someone of deliberate misconduct, which makes it even more of a stretch to name such an announcement defamatory, but that’s after all for the courts to determine. The McPherson family got a unique begin to their enterprise enterprise when they noticed an area need for peanut-drying equipment. Fazlul Sarkar— who has received $12.8 million in NIH funding and has been an investigator on five medical trials — has now filed suit Mergers & Acquisitions in Turkey towards PubPeer’s nameless commenters, and has demanded that PubPeer launch their names and figuring out info. You veered course at a sure level, now keep the course to the tip . The complaint, filed by lawyer Nicholas Roumel in Michigan’s Wayne County Circuit Court and which we’ve made obtainable right here, details extra of the historical past of the case and naturally describes the authorized strategy, which we’ll describe beneath.
However, the Russian invasion of Ukraine has made that transition much more durable as power security becomes a major drawback for many nations. French Cup winners Nantes have been held to an unispiring goalless draw at Angers on the opening weekend however gave the impression to be closing in on a first win of the season as they held out towards some sustained Lille attack In this AGM evaluate we discover the newest tendencies and set out some preliminary thoughts on what firms should be contemplating for subsequent 12 months. This publication explores the authorized and sensible challenges that have to be thought of. The 2022 AGM season has seen a big return to bodily in-person AGMs, decrease attendance figures, an increase in shareholder activism and revolutionary tactics used by protestors to seek to disrupt meetings.
Sometimes it was the prison guards and at different times, they have been officers in civilian clothes. The officers launched themselves as CID and advised me they had to take me for questioning. If I didn’t cooperate with them , they might slap me across the face. I was taken to the fourth ground of CID headquarters in Colombo. During the rape, law firm Vietnam they beat me and also burned me with cigarettes.
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Corruption and reportedly strengthened anticorruption efforts. Are complementary to the federal government coverage of social harmony. In 2003, whereas the manufacturing unit was state-owned, local residents protested the plant because of its pollution and were attacked and beaten. Representation, and higher safety under China’s labor legal guidelines.
Two academics were awarded the honorary title of My Favorite Teachers by Anhui University of Finance and Economics. Two teachers had been selected as High Productivity Authors in China law firm Panama Core Research Evaluation Sources Journal . An “urgent notice” by the SPC is thereforehighly unlikely to cut back the violence in these incidents, both on the half ofthe evictors and the evictees.
The 32-year-old Ismaily joined Lille from Ukrainian staff Shakhtar Donetsk final week and he scored within the 77th minute to keep up his new team’s unbeaten begin to the league. Brazilian defender Ismaily has scored on his debut in a 1-1 draw at Nantes in the French leagu Ismaily got here on as a halftime substitute in Nantes, where Moses Simon had given the house staff a 28th-minute lead. It was Nantes’ first aim of the season after a 0-0 draw with Angers in its opening recreation. Lille routed Auxerre 4-1 last weekend with an unfamiliar lineup under new coach Paulo Fonseca.
The best means to ensure most vaccination publicity is thru public dialogue that convinces the 48% that while the President could have had minimal well being issues from Covid-19 numerous folks do and will easily include you, your kids, your mother and father and your grandparents.


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Runaway (3) (The)
X:1 % T:Runaway , The M:6/8 L:1/8 R:Jig S:Frank Kidson – Old English Country Dances (1890) Z:AK/Fiddler’s Companion K:E B|e2e (eg).e|B2B (Bd).B|e2e (eg).e|(b3 b2)B| e2e (eg).e|B2B Bcd|e2e f>ef|(e3 ed2):| |:f|g>fe g>fe|a2(f f2)f|g>fe g>fe|B2(B B2)f| gfe gfe|agf b2a|gfe B2d|(e3 e2):||
RUNAWAY , THE. English, Country Dance Tune (6/8 time). E Major. Standard tuning (fiddle). AABB. Collector Frank Kidson noted "The Runaway " is from a musician's manuscript collection of about 1825. He also stated that it is different from a dance with this title that appears in dance books at the commencement of the (19th) century.

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We are a full-service mortgage company based in Tampa, Florida. We specialize in home loans in Central Florida. We also serve the surrounding cities. Whether you are buying a home or refinancing, we can help you realize your dream of homeownership or save you money when getting your new lower monthly payment. Offices In Tampa and Orlando

domain: finance


text:
Modded/Hacked Afterlife: RPG Clicker CCG Update
Size: 84.6 Mb
- Afterlife: RPG Clicker CCG
How to install:
For No-Root (Signed APKs):
1- Uninstall original game.
2- Download and Install modded APK.
3- Enjoy :D
For Game have obb or data:
1- Download OBB files or DATA files and extract files zip
2- Download mod APK
3- Move OBB Files (con.xxx folder) to Android/OBB folder in your device
- Or move Data files (com.xxx folder) to Android/data folder in your device 4- Install mod APK
5- Enjoy :D
The description of Afterlife: RPG Clicker CCG hack game
Afterlife – a clicker with a serious groundwork for an RPG.
The armies of the forces of Light and Darkness again challenged each other. The underground kingdom was chosen as the battlefield, a place where magic still exists, afterlife artifacts. To defeat the damned demons and monsters you need to find magic runes, powerful artifacts, gain experience and master the elemental magic. Tap, swipe and hold your finger on the screen to attack, defend and use spells. Pump the hero for the earned souls, become a magician, warriors, or combine different characteristics. Now the fate of the living and the whole universe depends on you.
One of the best implementations of the "clicker" genre. Endless possibilities for development, improvement and leveling. Many runes, artifacts, magic stones and objects.

domain: hobby


text:
VH1’s beloved, popular franchise “VH1 Divas” has announced additional performers to join this year’s dance music tribute.
Kelly Clarkson, Melanie Fiona, Metric and Pitbull will join VH1’s dance party, along with Havana Brown as House DJ/artist. Airing live from the L.A. Shrine Auditorium “VH1 Divas” will be hosted by Adam Lambert on Sunday, December 16 at 9PM/8c on VH1. To purchase tickets for VH1 Divas, click here.
This year “VH1 Divas” red carpet will be live streamed on DIVAS.VH1.com on Sunday, December 16 from 7-9PM ET/4-6PM PT (#VH1DIVAS). Sponsored by Samsung, the live stream will provide fans an unfiltered front-row seat to all the red carpet action and will feature real time interviews with entertainment’s biggest stars. Beginning Monday, December 17, fans can view a curated red carpet highlights video on DIVAS.VH1.com.
“VH1 Divas” is bringing together Ciara, Miley Cyrus, Demi Lovato, Kelly Rowland and Jordin Sparks to pay homage to the greatest divas of dance music with performances featuring current and classic dance hits. In the spirit of celebration and appreciation VH1 Divas will include a tribute to two divas we lost this past year, whose voices always lead us straight to the dance floor, Whitney Houston and Donna Summer.
As in previous years, this edition of “VH1 Divas” will benefit the VH1 Save The Music Foundation, a non-profit organization dedicated to keeping music education alive in American public schools. To date, VH1 Save The Music has provided more than $49.5 million in new musical instruments to 1,850 public schools in more than 128school districts around the country, impacting the lives of over 2.1 million children. To purchase tickets to the VH1 Divas live concert and Official After-party hosted by VH1 Divas and Foundation Ambassador Jordin Sparks with special Guest DJs, The Dolls: Mia Moretti and Caitlin Moe and KISSette, click here.
For more info about the event, click here

domain: entertainment


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The Thrilling World of Gambling: Unveiling the Secrets of Lottery, Slots, Casinos, SBOBET, and BaccaratJuly 21, 2023
Welcome to the thrilling world of gambling, where dreams are made or shattered in an instant. In this article, we will dive deep into the secrets of lottery, slots, casinos, SBOBET, and baccarat, giving you a glimpse into the adrenaline-fueled realm of chance and strategy.
Lottery, a game of luck that tantalizes millions with the promise of unimaginable fortunes, has long captured the imaginations of people from all walks of life. From picking your lucky numbers to anxiously watching the draw, the lottery embodies the excitement and anticipation that only gambling can bring.
If you prefer the allure of spinning reels and flashing lights, then slots may be your game of choice. These captivating machines can transport you to different worlds, where you can hit the jackpot and become an instant millionaire. With a myriad of themes and features to choose from, the possibilities are endless in the world of slot machines.
Casinos, on the other hand, offer a diverse array of games that cater to every gambling enthusiast. From the classic card games like poker and blackjack to the elegant spinning of the roulette wheel, stepping into a casino is like entering a world of endless possibilities. The hustle and bustle, the sounds of chips clinking, and the atmosphere of exhilaration make for an unforgettable experience.
For those seeking a different kind of thrill, SBOBET provides a platform for sports enthusiasts to bet on their favorite teams and players. Whether it’s football, basketball, or any other sport, SBOBET offers a chance to add an extra layer of excitement while watching the game unfold.
Last but certainly not least, we have baccarat, a game synonymous with glamour and sophistication. With its origins dating back to the 19th century, baccarat has been a favorite among high rollers for centuries. The combination of skill and chance makes this card game an intriguing option for those who appreciate the art of strategy.
So, whether you’re drawn to the thrill of the lottery, the excitement of slots, the glamour of casinos, the world of sports betting through SBOBET, or the elegance of baccarat, the world of gambling has something for every adventurous soul. Join https://medtravi.com/ as we unravel the secrets behind these games and embark on an unforgettable journey into the heart of chance and possibility.
Understanding the Basics of Baccarat
Baccarat is a popular casino game that has been enjoyed by many for ages. It is a card game that involves comparing the values of two hands – the player’s hand and the banker’s hand. The objective is to determine which hand will have a total value closest to nine.
To begin a round of baccarat, the player and the banker are each dealt two cards. The values of these cards are calculated by assigning each card a specific numeric value. Cards numbered 2 to 9 hold their face value, while 10s and face cards (such as Jacks, Queens, and Kings) have a value of zero. The Ace is valued at one.
Once the initial cards are dealt, the total value of each hand is calculated. If the total is more than nine, the tens digit is dropped, resulting in a single-digit value. For example, if a hand has a 7 and a 5, the total is 12. As the tens digit is dropped, the final value becomes 2.
In baccarat, players have the option to bet on either their own hand, the banker’s hand, or a tie. Bets must be placed before the cards are dealt. The hand that ultimately has a total value closest to nine wins the round, and bets placed on that hand are paid out accordingly. It’s important to note that the banker’s and player’s hands are not associated with the casino or the actual players present; they are simply terms used to represent the different betting options.
2. Exploring the World of Lotteries
Lotteries are a captivating aspect of the gambling world. They offer a unique opportunity for individuals to test their luck and potentially win life-changing prizes. With countless participants eagerly awaiting the results, the excitement surrounding lotteries is unparalleled.
In the realm of lotteries, players purchase tickets and select a combination of numbers, hoping that their chosen numbers will be drawn during the official draw. The anticipation leading up to the announcement is often filled with a mix of nerves and anticipation, as participants eagerly await the outcome.
Lotteries come in various forms, ranging from local, regional, and national draws to international ones. The prize pools can differ significantly, with some lotteries offering multimillion-dollar rewards. Whether it’s through selecting numbers based on special dates or utilizing random picks, the potential to win big keeps players engaged and optimistic.
Participating in lotteries can be an exhilarating experience, as it offers the chance to dream big and indulge in the thrill of the unknown. Each new draw brings the opportunity for someone’s life to change overnight, making lotteries one of the most popular forms of gambling worldwide.
3. The Allure of Slots and Casino Games
The world of gambling offers a captivating array of options for those seeking excitement and the chance to win big. From the thrill of pulling the lever on a slot machine to the allure of classic casino games, there is something for everyone in this electrifying realm.
Slots, with their flashing lights and enticing sounds, have gained immense popularity over the years. These games of chance provide an intriguing blend of simplicity and suspense. With a wide variety of themes and features, slots offer endless entertainment possibilities and the potential to strike it lucky with a winning combination.
For those seeking a more traditional gambling experience, casinos offer a realm of possibilities. From blackjack to poker, roulette to baccarat, these establishments provide a haven for enthusiasts looking to test their skills and luck. The elegant atmosphere and anticipation in the air create an exhilarating ambiance that is hard to replicate elsewhere.
One popular platform for gambling enthusiasts is SBOBET, offering an extensive range of options for those looking to place bets on their favorite sports events. Known for its reliability and user-friendly interface, SBOBET brings the excitement of sports betting right to your fingertips, allowing you to indulge in thrilling wagering experiences wherever you may be.
In conclusion, the world of gambling is a captivating and thrilling one, filled with opportunities to embrace the excitement of chance and potentially win big. Whether you prefer the simplicity of slots, the sophistication of casino games, or the thrill of sports betting, there is no shortage of options to explore and enjoy within this exhilarating realm.


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text:
Year Published : 2014
Genre : Contemporary Fiction, Mystery, Chick Lit
Edition : Kindle eBook
# of Pages : 460 pages
Time Spent Reading : 7.5 hours
A murder . . . a tragic accident . . . or just parents behaving badly?
What’s indisputable is that someone is dead.
But who did what?
Big Little Lies follows three women, each at a crossroads:
Madeline is a force to be reckoned with. She’s funny and biting, passionate, she remembers everything and forgives no one. Her ex-husband and his yogi new wife have moved into her beloved beachside community, and their daughter is in the same kindergarten class as Madeline’s youngest (how is this possible?). And to top it all off, Madeline’s teenage daughter seems to be choosing Madeline’s ex-husband over her. (How. Is. This. Possible?).
Celeste is the kind of beautiful woman who makes the world stop and stare. While she may seem a bit flustered at times, who wouldn’t be, with those rambunctious twin boys? Now that the boys are starting school, Celeste and her husband look set to become the king and queen of the school parent body. But royalty often comes at a price, and Celeste is grappling with how much more she is willing to pay.
New to town, single mom Jane is so young that another mother mistakes her for the nanny. Jane is sad beyond her years and harbors secret doubts about her son. But why? While Madeline and Celeste soon take Jane under their wing, none of them realizes how the arrival of Jane and her inscrutable little boy will affect them all.
Big Little Lies is a brilliant take on ex-husbands and second wives, mothers and daughters, schoolyard scandal, and the dangerous little lies we tell ourselves just to survive.
I just want to start this review by saying that there are certain things that I tend to avoid when considering books. This one has almost all of those things and yet I absolutely loved it, go figure. I have nothing but good to say about the writing style. It’s very simple, direct, yet manages to bring life and noticeable variance to the characters. A total page turner. I was completely pulled into the world of the characters and grew to appreciate each one of the three main protagonists. To sum it all up, I loved this one.
So those things I tend to avoid- chick lit contemporaries about motherhood and marriage. Settings that are a little too clean and down-to-earth. I prefer the fantastical over the realistic, and gritty over easygoing. Just a cursory glance might make this novel seem like a sort of cross between a mommy blog and family sitcom- it’s really not.
Right from the start the atmosphere is a little off-kilter, a bit quirky and whimsical in an almost parodic way. We find out quickly that one of the major characters is going to die. We see a mixture of the past events and humorous little crime interview snippets with side characters in the present. I changed my mind at several junctures about who I thought was going to die- and who the killer might be. This set up is very dynamic and interesting. The shifts from humorous to serious are smoothly handled. The heavier subject matter (the main one being domestic violence) was poignant and intense in conveying the complex issues facing the character dealing with that situation. There is more than meets the eye to each of the three main characters.
As mentioned prior, this is a fast read. The pace is great, though I did get impatient with parts toward the the last quarter or so. By that point I’d become attached enough to the characters that I worried for how things might turn out for them, just dying to know what all happens on the pivotal “trivia night” where chaos is hinted to ensue. The ending was worthwhile (I actually loved it, for a certain personal reason) and not too guessable.
Overall Rating – 10/10
Why You Should Try It – Excellent writing that manages to be simple yet effective at bringing the characters to life. The three main characters could be considered similar but through the strength of great characterization I never mixed them up. The murder mystery is plotted in a clever way. A nearly unguessable ending.
Critique – For those who are looking for an all-focused mystery, the focus on characters and their day-to-day problems might not be riveting enough. The trivia night probably could have been more explosive for all the tension leading up to it.
Click below to check out Big Little Lies on AmazonBig Little Lies
4 thoughts on “Full Review : Big Little Lies by Liane Moriarty”


Hi to all,
What is the best method for getting a single rich tone from a chromatic harmonica? e.g. Suzuki, CHROMATIX SCX-48.
Is it a good idea to say the word “KOOH” while blowing or drawing from a hole?
Hi to all,
Howdy new friend.
Most info here will be for diatonics. Personally, I haven’t played a chromatic in years, and then I really only played with them. I DID buy a Hohner Super Chromomica (I only mentioned the full name because I’m super too LOL) 270.
Great instrument! I’ll be working on this one as I continue with my beloved MB and LO.
Hey SPD! You won’t believe what I paid for this or the guitar I recently bought. The 270 is NOS with original paperwork (big deal).
BTW, just relax and have fun with your new instrument.
Oh yeah? Well I got a Hohner Super Chromonica 270! ROFL!!!
Check out slidemeisters.com…ole @ge will take care of you on those topics!
I’ve wanted to get another chromatic for a long time, but the price for something I really couldn’t play…well I couldn’t turn this one down at the price. Brings back childhood memories with my Dad’s big 64.
I hear ya bro! No offence meant, I hope!
Yeah, sometimes I wonder if that cash could have been spent on another instrument that I can’t play…say a tuba or something…
But I enjoy playing on it once in a while…though I can hardly do it…
I greatly GREATLY admire people like ole Toots Thielemans who play it with a magical feel…
Toots Thielemans - Bluesette
But someday I may yet achieve something close to that! So we harp on!
Peace Out Bro!
I personally advise against any chromatics of the lower class. Thus said, I think CX-12 is the entry model one should consider (if you take the Hohner model line). I’ve had several 270’s and 270deluxes for repair and… god should punish its engineers.
Well Jim, I got mine, new old stock, for $20. I’m not worried about playing it like a seasoned pro. I’m not one of those. I do happen to be a seasoned pro trumpet man, and I’ve played or warned against many low quality instruments. It’s not always the highest dolllar that gets the best quality, but you do have to put down a pretty penny still for fine craftsmanship. I usually play vintage instruments to get the quality, sound, and styling I prefer. But even a cheap horn is USUALLY worth $20 for the few months it will last a novice (unless it’s so bad it’s unplayable for a beginner). There are things I don’t like about this harp, so I’ll probably either learn to work on it or put up with it.
Seriously though, what would you consider an acceptable quality chromatic?
I personally favor the Seydel Saxony. It has stainless steel reeds, which means they will never get out of tune (and tuning a chromatic is a pain…). They are also very durable. It has very comfortable mouthpiece, and reliable valves. It just feels… reliable. When you bend a valve note for example, you don’t have that feeling that it will break.
Other good options are Hohner CX-12 (some say the CX12 jazz version is more comfortable), and Suzuki SCX.


Tag : Terror Attacks
title : Donald Trump Backtracks His Support over U.S Muslim Registration
summary : Donald Trump withdrew his support for a government database to take surveillance on Muslims in the United States. The Republican presidential candidate reasoned the Muslim registration suggestion came from a reporter.
date : Nov 22, 2015 05:23 PM EST


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text:
Overcome your pupil financial obligation. Refinance now.
It was compiled by Olivia Kendall, a customer delight group lead at Earnest.
I simply paid every one of my student loans — and my FICO took an enormous, 40-point hit! exactly What offers? We thought reducing my debt as fast as possible (while nevertheless adding frequently to an urgent situation investment) ended up being the accountable thing to do? Shouldn’t my score get UP by 40 points once I prove I’m the lowest credit danger if you are paying my loans in full, sooner than expected?
Sleepless in San Francisco
Congratulations on doing your education loan re payments! Irrespective of what’s happened to your FICO rating, that’s a huge achievement and maybe maybe not the need to make those monthly premiums will free up a lot more of your revenue to complete things like invest, save yourself, or treat yourself.
The TL;DR answer to “Shouldn’t my score get up whenever I pay back my education loan debt?” is: definitely not. Here’s why.
Why loansolution.com/installment-loans-nc Do Final Re Re Re Payments on Student Education Loans Affect The Credit History?
It can impact your FICO score in a couple of ways when you pay off a loan and then close the related account. (an instant refresher on your FICO rating: The formula major credit agencies use to calculate accurately this quantity has numerous facets, including credit utilization, the size of credit rating, re payment history, and credit mix.)
First, once you close a revolving account (like credit cards) it could influence your credit utilization ratio or perhaps the quantity of revolving debt you’ve got in accordance with the available credit you’ve got. If you close an unused $0 stability bank card, your utilization ratio will increase. And therefore could adversely affect your FICO rating.
Then, the closing of a merchant account could zap the payment history related to that account. a history that is long of payment helps grow your credit—but in the event that you close that account, there goes its history along with it. Which could additionally negatively influence your rating.
Third, once you close your education loan reports, that are considered installment loans, and possess only credit that is revolving (such as your bank card) or hardly any other credit at all remaining—your credit mix can change. This might additionally adversely impact your FICO score. You can have federal figuratively speaking or personal figuratively speaking, repaying your complete loan stability will shut your bank account utilizing the servicer and influence your credit.
The greater amount of credit rating you’ve got, the less your FICO will likely to be influenced by single occasions like shutting a free account.
Just how to Quickly Correct Your Credit Rating
In the event the good credit rating did just take a winner, and you’re searching to construct it back up in a short span of the time, you may consider utilizing credit cards or other kinds of credit in an accountable method as a method to enhance your good credit. The easiest method to make this happen would be to always spend your balance off in complete every month, and keep carefully the account available even when you’re staying away from it on a monthly basis.
Showing that one can sensibly handle both installment debt ( like a learning education loan or car loan) and revolving (like credit cards) is an issue in your current rating. This assists with enhancing your credit mix. In the event the credit report is fairly slim (in other terms., if you can find few people like going products inside it either since you are not used to credit or perhaps you don’t apply it in the monetary strategy) then credit mix is also more crucial.
Moving forward, realize that showing lenders that you’re both predictable and accountable is sometimes more advantageous than simply showing that you’re accountable, at the least from the viewpoint of FICO scoring.
Finally, something else to be equipped for whenever shutting a free account could be the prospect of costs. Within the world of lending organizations, whenever a debtor takes care of their loan ahead of the payment plan term flow from, it is considered a “prepayment.” One explanation numerous loan servicers don’t like prepayment is it harder to track and manage loans that it makes. In reality, numerous old-fashioned loan providers discourage individuals from carrying this out by imposing an extra charge if they pay back their loan ahead of the deadline. (Note: Earnest never ever charges charges for additional re re payments or settling that loan.)
Which are the most readily useful steps you can take to guarantee your credit rating improves as time passes so loan providers will offer you reduced interest levels? Be mindful of your own personal funds and banking account, make inquiries, stay static in good standing together with your loan providers, while making yes you truly comprehend the regards to any brand new loan or personal credit line.
Unique compliment of John Davidson, an underwriter at Earnest, for his efforts to this piece.


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Department of health has issued a warning that the cases of dengue are increasing rapidly in Western Visayas and if people will not take immediate preventive measures, it’s inevitable outbreak will not be able to controlled.
After reviewing the data released by the National Epidemiology Center, Health Secretary, Enrique Ona yesterday said that dengue cases have increased tremendously in regions like Metro Manila, Western Visayas and Central Visayas.
According to the DOH 6 records, in Western Visayas from January to August, 11,896 dengue cases have been recorded.
After reviewing the recent data over the increase of dengue cases, Ona has been encouraging people to visit their local health centers, if they see any symptoms of dengue.
This will help the workers at the health centre to treat the patients shortly, if they will be on the initial stage of the disease and in that case they will not require hospitalization.
“Many dengue cases, if mild, can be managed at home or closely monitored by our local health workers in the various communities since not all dengue cases require hospitalization”, he said.
He also said that symptoms of bronchitis, the regular flu and cold are similar to the symptoms of dengue.

domain: geography