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Cycling Road World Championships Review
The 2019 UCI Road World Championships took place last week with racing between Sunday 22 and 29 of September. It was a thrilling renewal of an event that has grown in popularity dramatically in recent times, especially amongst a British audience.
The spotlight was on this event to do its bit to help further boost the profile of cycling road races in this country and we’re delighted to report the results and action more than did the job. Yorkshire provided the backdrop to this year’s event and fans turned out in their numbers to support the racing and cheer on their favourite competitors. There was also many more watching the live coverage that was available on TV, streams and mobile apps.
There has never been a better time to be a fan of cycling due to the ever-increasing amount of coverage of the sport now available. That also extends to the betting and major bookmakers now allow members an opportunity to back their opinions with hard cash and get their money down on a number of exciting markets. Pre-race, sports bettors could wager on the winner of the 2019 Cycling Road World Championships or try their luck on one of the many interesting specials available.
Live sports action is enjoyable, but it doesn’t quite compare to making a profit from the play and the opportunity to bet on cycling helps promote it to the wider audience, including casual fans eager to boost their betting account balance with a winning bet. You may be an avid supporter of British cycling or a punter with a passing interest, the joy of landing a winning bet feels the same regardless.
Yorkshire Stands as the Host County
Last week signalled the 92nd renewal of the Cycling Road World Championships but it was only the fourth time the event had been held in the United Kingdom. That was surprising but it does go to show how far the sport in this country has progressed in recent times. The London 2012 Olympics helped set-up the facilities for a number of usually niche sports to be promoted to the wider public and there can be no doubt the summer of 2012 has had a sporting legacy in this country.
Usually, a single town or city would stand as the host of this competition, but times are changing and this year we saw the county of Yorkshire was the official host. North Yorkshire did play an important role, however, and each race finished in Harrogate. Other locations in 2019 were Beverley, Doncaster, Leeds, Northallerton, Ripon and York. This gave organisers the chance to really push the sport of cycling to a larger audience, bringing it directly to the British people and presenting more members of the public with an opportunity to come out and watch live cycling on their doorstep. It had the desired effect and the crowds filled the Yorkshire streets to watch the best in the business speed past as they aimed at glory.
The schedule also gave an exciting mix of different styles of racing. On Sunday 29 September the mixed relay race took place over a distance of 17.1 miles and that finished in Harrogate. Next was the individual team trial events. On Monday we saw the junior women and junior men races also start and finish in Harrogate before the under 23 men and elite women raced from Ripon to Harrogate on Tuesday.
Flying Dane Mads Pedersen Wins Men’s Event
The elite men took to the stage on Wednesday and that race began in Northallerton and was decided over a painful 34 miles. That’s the one much of the crowd came out to see and they weren’t left disappointed. The road race events were next and these pulled in a big audience on each of the days of play. The junior men raced on Thursday, the junior women and under 23 men taking place on Friday to kick-start the weekend. It was then that things got serious.
Saturday 28 September brought us the elite women’s race which began in Bradford and finished in Harrogate over a distance of 92.8 miles. The star of the show and main attraction was reserved for Sunday when the elite men’s race challenged the best cyclists in the world over a gruelling trip of 162 miles between Leeds and Harrogate with no less than nine laps standing between the opening field and this year’s champion.
The results show Mads Pedersen of Denmark was the men’s elite champion and he was joined on the podium by Annemiek van Vleuten of the Netherlands who won the women’s road race. The winning time of Pedersen was 6h 27m 28s and that saw him finish ahead of runner up Matteo Trentin of Italy and third-placed Stefan Kung of Switzerland. Annemiek van Vleuten posted a time of 4hrs 06m 05s in the women’s elite road race, enough to see off runner-up Anna van der Breggen, also of Holland. Aussie Amanda Spratt crossed the line back in third to take a well-deserved bronze medal.
USA Top the Charts
Britain may have been the host nation, but the team performed poorly at this event and finished bottom of the medal table, with a return of no gold medals, no silvers and three bronze. That placed them down in 10th, behind the likes of Switzerland, Belgium and Russia, proving just how much work lies ahead of Team GB if they are to close the gap on the main players at this level of competition. The USA topped the charts with a return of three gold medals, one silver and a couple of bronze.
The six gained meant they didn’t claim the most medals of the week, but they did finish with the best results. Team USA edged the Netherlands who did bank more prizes than any other nation on eight medals. That haul was made up of two golds, four silvers and two bronze. The nation performed admirably in most races and would have returned home disappointed not to have finished on top of the medals table. The Italians were back in third with two gold, two silver and one bronze, more than holding their own over the course of the week, as was expected.
Holland won the mixed relay and that event was met with much interest. The team of Lucinda Brand, Riejanne Markus, Amy Pieters, Koen Bouwman, Bauke Mollema and Jos van Emden were crowned champions, seeing off a spirited German side who finished in second with Great Britain crossing the line in third. There were some real positives for Team GB in that race and they will be eager to pick out encouragement from that, rather than the fact they finished bottom of the medal charts. British cycling is improving but organisers will want to see results in the near future.
Pedersen Surprised Himself and His Team
The men’s elite race was won by Mads Pedersen, as mentioned, with the top 10 places reading as follows…
1 Mads Pedersen 6hr27sec
2 Matteo Trentin +0
3 Stefan Kung +2
4 Gianni Moscon +17
5 Peter Sagan +43
6 Michael Valgren Andersen +45
7 Alexander Kristoff +1min10sec
8 Greg van Avermaet +1min10sec
9 Gorka Izagirre Insausti +1min10sec
10 Rui Costa +1min10sec
Speaking to the press following his impressive win, Mads Pedersen called his win unbelievable and a result that came as a shock to him and the team. The champion told fans his initial aim was just to survive the race in difficult conditions but admitted it was his dream to wear the jersey and he was glad his body was able to hold off the pain of over six hours on the bike to put in a sprint finish to seal victory against all the odds.
It was a thrilling finish to a race that proved an enjoyable watch from the start., Mads Pedersen stuck with the leaders, remaining on the wheels of Italian rival Matteo Trentin heading for the finish line. The champion then found the change of gear needed to accelerate away to the finish line and that proved to be the difference in what was a tight contest. The 23-year-old victor kept something in the tank and delivered his assault perfectly, leaving Trentin behind with no chance of challenging in the final few yards.
Trentin Should have Gambled
Conditions also made racing difficult and the runner up looked to adopt a sensible approach that cost him victory. He allowed his rivals to take a lead going into a tight corner and we’d imagine he now wishes, with the benefit of hindsight, that he’d been a little braver and took on the risk of a late crash in an attempt to win gold.
We’re sure the Italian would have learned a few lessons from that day and will come back stronger for the experience. Pederson would have also learned a thing or two about himself and is sure to be popular with punters in the next big event.
Staging the Cycling Road World Championships helped secure £15m worth of funding towards the construction of more than 25 off-road racing venues around the UK and that will be the legacy of this event for years to come.


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A common pathogenic link in type 2 diabetes mellitus (T2D) and coronary artery disease (CAD) is oxidative stress, which develops as a result of an imbalance in the production of reactive oxygen species (ROS) and their neutralization by the antioxidant defense system. Neutrophilic cytosolic factor 4 (NCF4) is directly involved in the synthesis of superoxide anion as part of NADPH oxidase. In this regard, the purpose of this study was to investigate the associations of eight single nucleotide polymorphisms of the NCF4 gene rs5995355 (A>G), rs5995357 (T>A), rs1883112 (G>A), rs4821544 (G>A), rs760519 (T>C), rs729749 (C>T), rs2075938 (G>A), rs2075939 (C>T) with a predisposition to T2D, as well as the risk of developing CAD in patients with T2D. The study included 1579 patients with T2D (448 of them were also diagnosed with CAD) and 1627 relatively healthy volunteers. Genotyping was performed using MALDI-TOF mass spectrometry on the MassArray Analyzer 4 platform. Statistical processing of the obtained data was carried out using the SNPStats online program. The allele and genotype frequencies of the studied SNPs in T2D patients did not differ from those in the control group (P>0.05). Associations of genotypes rs4821544-C/C (OR 1.71, 95CI 1.12-2.59, P=0.013) and rs5995357-A/A (OR 3.74, 95CI 1.14-12.31, P=0.026) with a predisposition to CAD in diabetic females were established. Despite the absence of associations of the studied SNPs NCF4 with CAD in males, associations of the haplotype structure of NCF4 (P=0.0064), as well as the haplotypes H2 (OR 1.79, 95CI 1.16-2.76, P=0.0085) and H3 (OR 1.77 , 95CI 1.06-2.97, P=0.03) with an increased risk of CAD were observed exclusively in diabetic males. In addition, a sex-independent relationship of the rs4821544-C/C genotype with an increased level of glycated hemoglobin (P=0.032) and oxidized glutathione (P=0.049) was revealed in patients with CAD and T2D. In the same category of patients haplotypes H4 rs5995355G-rs5995357A-rs1883112G-rs4821544C-rs760519T-rs729749C-rs2075938G-rs2075939C and H10 rs5995355A-rs5995357T-rs1883112G-rs4821544C-rs760519T-rs729749C-rs2075938A-rs2075939C of NCF4 gene were associated with an increase in the content of HbA1c 8.67 % (P=0.011) and 6.27% (P=0.038), respectively. The data obtained indicate a significant contribution of the NCF4 gene polymorphism to the pathogenesis of CAD in patients with T2D and create a scientific basis for the development of targeted therapy and prevention of this pathology.
In a study involving 2830 subjects including 1444 patients with type 2 diabetes (T2D) and 1386 healthy controls, an association of the rs1046495 polymorphism of the GFER gene encoding FAD-dependent sulfhydryl oxidase with decreased risk of the disease in non-obese patients was found (OR 0.76, 95CI 0,57-0,99, P=0,029). The protective effect of the gene polymorphism remained significant in individuals who consumed fresh vegetables and fruits (P=0.014), proteins (P=0.0017), and did consume carbohydrates and fat reached foods (P=0.0047). The mechanism of the relationship of the minor allele rs1046495-C with type 2 diabetes may be associated with its more pronounced effect on the expression of the GFER enzyme, which, as is known, through glutathionation, maintains the ROS level for the optimal functioning of complexes III and IV of the electron transport chain and promotes the formation of disulfide bonds in the CHCHD4 chaperone molecule, the impairment of the activity of which underlies mitochondrial dysfunction, that represents one of the key pathological changes in patients with T2D.
Background: Phosphatidylethanolamine N-methyltransferase (PEMT) is the enzyme of lipid metabolism that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in a series of three methylation reactions. Low activity of the enzyme can increase the availability of phosphatidic acid for triacylglycerol synthesis and thus favor obesity, one of the most important risk factors for type 2 diabetes (T2D). The aim of the study: To study the relationship of the rs12449964 (C>T) in the regulatory region of the PEMT (phosphatidylethanolamine-N-methyltransferase) gene with blood plasma triglycerides, as well as the risk of obesity and T2D in population of Central Russia. Materials and methods: The study included 2060 unrelated individuals of Slavic origin, including 1024 patients with T2D and 1036 healthy volunteers. Genotyping of PEMT gene polymorphism (C>T, rs12449964) was performed by laser desorption / ionization time-of-flight mass spectrometry using the MassArray Analyzer 4 platform (Agena Bioscience). SNPStats online program was used for statistical analysis of the obtained data. Results: Linear regression analysis did not reveal an association of rs12449964 of the PEMT gene with a risk of developing T2D regardless of body mass index (P>0,05). However, the T/T genotype of the studied SNP is associated with an increased risk of obesity in patients with type 2 diabetes (OR 1.66; 95% CI 1.11-2.46; P = 0.011, adjusted for sex and age, recessive model). In addition, carriage of the T/T genotype was associated with a higher level of triacylglycerols in the blood plasma of patients with T2D, both in the presence of obesity and without it (P<0.05). According to GTEx Portal, the rs12449964T allele is associated with decreased PEMT expression in various tissues. Conclusion: The study revealed for the first time the association of rs12449964 of the PEMT gene with hypertriglyceridemia and an increased risk of obesity in patients with T2D, which may be due to the low transcriptional activity of the phosphatidylethanolamine- N-methyltransferase gene in carriers of the alternative allele of the studied SNP.
The present study investigated whether type 2 diabetes (T2D) is associated with polymor-phisms of genes encoding glutathione-metabolizing enzymes such as glutathione synthetase (GSS) and gamma-glutamyl transferase 7 (GGT7). A total of 3198 unrelated Russian subjects including 1572 T2D patients and 1626 healthy subjects were enrolled. Single nucleotide polymorphisms (SNPs) of the GSS and GGT7 genes were genotyped using the MassArray-4 system. We found that the GSS and GGT7 gene polymorphisms alone and in combinations are associated with T2D risk regardless of sex, age, and body mass index, as well as correlated with plasma glutathione, hydrogen peroxide, and fasting blood glucose levels. Polymorphisms of GSS (rs13041792) and GGT7 (rs6119534 and rs11546155) genes were associated with the tissue-specific expression of genes involved in unfolded protein response and the regulation of proteostasis. Transcriptome-wide association analysis has shown that the pancreatic expression of some of these genes such as EDEM2, MYH7B, MAP1LC3A, and CPNE1 is linked to the genetic risk of T2D. A comprehensive analysis of the data allowed proposing a new hypothesis for the etiology of type 2 diabetes that endogenous glutathione deficiency might be a key condition responsible for the impaired folding of proinsulin which triggered an unfolded protein response, ultimately leading to beta-cell apoptosis and disease development.
The present study was designed to investigate whether the genetic predisposition to type 2 diabetes (T2D) is associated with polymorphisms of genes encoding glutathione-metabolizing enzymes such as glutathione synthetase (GSS) and gamma-glutamyl transferase 7 (GGT7), and also to analyze in silico the molecular mechanisms of their involvement in disease pathogenesis. A total of 3198 unrelated Russian subjects including 1572 T2D patients and 1626 healthy subjects were enrolled. Single nucleotide polymorphisms (SNP) of the GSS and GGT7 genes were genotyped using the MALDI-TOF mass spectrometry iPLEX platform. We found for the first time that SNPs rs11546155 (OR 0.42, 95%CI 0.22-0.80, P=0.022) and rs6119534 (OR 0.73, 95%CI 0.53-0.99, P=0.0003) of the GGT7 are significantly associated with T2D regardless of sex, age, and body mass index. The association of SNP rs11546155 with diabetes risk has been replicated in a large ethnically diverse cohort (P=0.018). The GSS and GGT7 polymorphisms in diabetics correlated with the levels of plasma glutathione, hydrogen peroxide, and fasting blood glucose in a gender-specific manner. Epistatic interactions between the gene polymorphisms determining disease susceptibility have been observed with strong protective effects of genotype combinations such as GGT7 rs6119534-C/T × GSS rs1801310-A/A and GGT7 rs6119534-C/T × GSS rs13041792-G/G against disease risk (FDR<1.8×10-5). The risk alleles of GSS and GGT7 correlated with tissue-specific expression of genes located at genomic region 20q11.22 that spans numerous genes involved in the unfolded protein response pathway and regulation of proteostasis. Transcriptome-wide association analysis has shown that pancreatic expression of some of these genes such as EDEM2, MYH7B, MAP1LC3A, and CPNE1 is linked with the genetic susceptibility to type 2 diabetes. Taken together the study findings along with our previous results allowed proposing a new hypothesis for the etiology of type 2 diabetes that endogenous deficiency of glutathione is a key condition responsible for impaired folding of proinsulin and triggering unfolded protein response which ultimately leads to β-cell apoptosis, disease development, and progression.
The scientific article is devoted to the study of the relationship between the polymorphic loci in the CDKAL1 gene encoding the methylthiotransferase enzyme and the risk of developing type 2 diabetes mellitus (T2D) in 3206 unrelated individuals - 1579 patients with T2D and 1627 healthy volunteers. It was established for the first time in the Russian population that carriage of minor alleles of single nucleotide variants rs4712524 (G>A) and rs6931514 (G>A) in the CDKAL1 gene is associated with increased risk of T2D, regardless of age, sex and body mass index of the patients.
Higher rates of serious illness and death from coronavirus SARS-CoV-2 (COVID-19) infection among older people and those who have comorbidities suggest that age- and disease-related biological processes make such individuals more sensitive to environmental stress factors including infectious agents like coronavirus SARS-CoV-2. Specifically, impaired redox homeostasis and associated oxidative stress appear to be important biological processes that may account for increased individual susceptibility to diverse environmental insults. The aim of this Viewpoint is to justify (1) the crucial roles of glutathione in determining individual responsiveness to COVID-19 infection and disease pathogenesis and (2) the feasibility of using glutathione as a means for the treatment and prevention of COVID-19 illness. The hypothesis that glutathione deficiency is the most plausible explanation for serious manifestation and death in COVID-19 patients was proposed on the basis of an exhaustive literature analysis and observations. The hypothesis unravels the mysteries of epidemiological data on the risk factors determining serious manifestations of COVID-19 infection and the high risk of death and opens real opportunities for effective treatment and prevention of the disease.
The present study investigated a joint contribution of matrix metalloproteinases (MMPs) genes to ischemic stroke (IS) development and analyzed interactions between MMP genes and genome‐wide associated loci for IS. A total of 1288 unrelated Russians (600 IS patients and 688 healthy individuals) from Central Russia were recruited for the study. Genotyping of seven single nucleotide polymorphisms (SNPs) of MMP genes (rs1799750, rs243865, rs3025058, rs11225395, rs17576, rs486055, and rs2276109) and eight genome‐wide associated loci for IS were done using Taq‐Man–based assays and MALDI‐TOF mass spectrometry iPLEX platform, respectively. Allele − 799T at rs11225395 of the MMP8 gene was significantly associated with a decreased risk of IS after adjustment for sex and age (OR = 0.82; 95%CI, 0.70‐0.96; P = 0.016). The model‐based multifactor dimensionality reduction method has revealed 21 two‐order, 124 three‐order, and 474 four‐order gene‐gene (G×G) interactions models meaningfully (Pperm < 0.05) associated with the IS risk. The bioinformatic analysis enabled establishing the studied MMP gene polymorphisms possess a clear regulatory potential and may be targeted by gene regulatory networks driving molecular and cellular pathways related to the pathogenesis of IS. In conclusion, the present study was the first to identify an association between polymorphism rs11225395 of the MMP8 gene and IS risk. The study findings also indicate that MMPs deserve special attention as a potential class of genes influencing the multistep mechanisms of cerebrovascular disease including atherosclerosis in cerebral arteries, acute cerebral artery occlusion as well as the ischemic injury of the brain and its recovery.
Дисбаланс в функционировании про- и антиоксидантной систем играет ключевую роль в патогенезе сахарного диабета 2-го типа (СД2) и отражается в характере манифестации заболевания, спектре и скорости прогрессирования развивающихся на его фоне осложнений, эффективности лечения. Цель исследования – изучить антиоксидантный статус больных СД2, а именно, содержание глутатиона и активных форм кислорода и азота (АФКА) в плазме крови, и установить связь этих фенотипических проявлений с генетическими полиморфизмами генов антиоксидантных ферментов глутатион-S-трансфераз M1 и T1. В исследование были включены 600 больных СД2 (средний возраст 61,7±10,1 лет) и 520 практически здоровых добровольцев (средний возраст 60,9±8,3 лет). Генотипирование делеционных (del) полиморфизмов генов GSTM1 и GSTT1 выполнено методом мультиплексной ПЦР. Содержание общего глутатиона и АФКА проводили с использованием наборов STA-312 и STA-347 (“Сell Biolabs”, США) на микропланшетном ридере “Varioscan Flash” (“Thermo Fisher Scientific”, США). Частоты генотипов GSTM1 у больных СД2 не отличались от соответствующих показателей лиц контрольной группы (р>0,05), тогда как частота делеционного генотипа del/del GSTT1 была значимо выше в группе больных (OR 1,60, 95CI 1,17–2,21, p=0,003) по сравнению со здоровыми. Обнаруженная ассоциация сохранила свою значимость после коррекции по полу, возрасту и индексу массы тела (р=0,004). Концентрация АФКА была выше в группе больных (3,21±1,18 мкмоль/л) по сравнению со здоровыми (2,50±1,33, р=0,02), что сочеталось с повышенным содержанием окисленного глутатиона: 7,72±5,93 мкмоль/л у пациентов с СД2 относительно 5,72±3,60 у лиц контрольной группы. Было обнаружено, что все носители генотипа del/del GSTT1 имели более высокие уровни АФКА (р=0,04) независимо от статуса болезни. Полученные результаты свидетельствуют о том, что антиоксидантные гены, в частности, GSTТ1, определяют эффективность обезвреживания АФКА и их количественное содержание в плазме крови. Косубстрат глутатион-S-трансфераз, глутатион, может рассматриваться как потенциально новый компонент антиоксидантной терапии, особенно для лиц с наследственной предрасположенностью к свободно-радикальной патологии, какой является СД2.
Oxidative stress contributes to the pathogenesis of type 2 diabetes (T2D). This study investigated whether single nucleotide polymorphisms (SNPs) at genes encoding glutamate cysteine ligase catalytic (rs12524494, rs17883901, rs606548, rs636933, rs648595, rs761142 at GCLC) and modifer (rs2301022, rs3827715, rs7517826, rs41303970 at GCLM) subunits are associated with susceptibility to type 2 diabetes. 2096 unrelated Russian subjects were enrolled for the study. Genotyping was done with the use of the MassArray System. Plasma levels of reactive oxygen species (ROS) and glutathione in the study subjects were analyzed by fuorometric and colorimetric assays, respectively.The present study found, for the frst time, an association of SNP rs41303970 in the GCLM gene with a decreased risk of T2D (P=0.034, Q=0.17). Minor alleles such as rs12524494-G GCLC gene (P=0.026, Q=0.17) and rs3827715-C GCLM gene (P=0.03, Q=0.17) were also associated with reduced risk for T2D. Protective efects of variant alleles such as rs12524494-G at GCLC (P=0.02, Q =0.26) and rs41303970-A GCLM (P=0.013, Q =0.25) against the risk of T2D were seen solely in nonsmokers. As compared with healthy controls, diabetic patients had markedly increased levels of ROS and decreased levels of total GSH in plasma. Interestingly, fasting blood glucose level positively correlated with oxidized glutathione concentration (rs=0.208, P=0.01). Three SNPs rs17883901, rs636933, rs648595 at GCLC and one rs2301022 at GCLM were associated with decreased levels of ROS, while SNPs rs7517826, rs41303970 at GCLM were associated with increased levels of total GSH in plasma. Single nucleotide polymorphisms in genes encoding glutamate cysteine ligase subunits confer protection against type 2 diabetes and their efects are mediated through increased levels of glutathione.
Oxidative stress is an important component of the pathogenesis of type 2 diabetes mellitus (T2D). Glutathione peroxidase 2 is one of the antioxidant defense enzymes which uses glutathione as a co-substrate to reduce hydrogen peroxide and has the highest expression in the pancreas, an organ that is directly related to the development of diabetes. However, there is no data on the association of GPX2 with a predisposition to T2D. The aim of the study was to investigate the association of rs4602346 (A>G) in the intron of the GPX2 gene with a risk of T2D, as well as the effect of this SNP on blood plasma redox homeostasis. The study included 3197 unrelated individuals of Slavic origin, including 1570 patients with T2D and 1609 age- and sex-matching healthy volunteers. GPX2 gene polymorphism was genotyped using real-time PCR on a CFX96 Touch Bio-Rad thermal cycler. The G/G genotype was associated with an increased risk of the disease (OR 1,41, 95% CI 1,02-1,96, P=0,039, recessive model). The identified association retained its significance even after correction for gender, age, and body mass index (ORadj 1,50, 95% CI 1,04-2,16, Padj=0,03). Gender-stratified analysis revealed that the established association of rs4902346 was characteristic only for diabetic males (ORadj 2,09, 95% CIadj 1,22-3,59, Padj=0,0065), and was not observed in diabetic females (P>0,05). Assessment of redox status showed an increase in the content of hydrogen peroxide and a decrease in the level of total glutathione in the plasma of patients compared with the control (P <0.05). A correlation analysis found that patients' hydrogen peroxide levels are directly proportional to their fasting blood glucose concentrations. An analysis of the relationships between genetic and biochemical data showed that the G/G genotype rs4902346 is associated with a decrease in the content of reduced glutathione in the plasma of female patients with T2D (P=0,0086). Thus, we identified for the first time the association of rs4902346 with an increased risk of T2D and showed significant gender differences in the associations of the GPX2 gene with the studied phenotypes.
The aim of the study was to investigate the associations of single-nucleotide polymorphisms (SNP) rs5917471, rs5963327 and rs6610650 of the gene encoding the beta chain of cytochrome b-245 of NADPH oxidase (CYBB gene) with the redox-homeostasis parameters of blood plasma and the risk of development of type 2 diabetes mellitus (T2D). The study included 2086 unrelated individuals of Slavic origin (1022 patients with T2D and 1064 healthy volunteers). Genotyping of SNPs was performed on a MassArray Analyzer 4 genomic mass spectrometer. Due to the localization of the CYBB gene on the X chromosome, the analysis of the effect of its single nucleotide variants on the predisposition to diabetes mellitus and the parameters of the redox status of blood plasma was carried out separately in men and women by the method of linear regression analysis, adjusted for age and body mass index. In men, the association of the allele T rs5963327 (OR 1.7, 95% CI 1.06–2.75, P = 0.028) and the allele A rs6610650 (OR 1.71, 95% CI 1.05–2.78, P = 0.029) with an increased risk of T2D development was established. Genotype T/T rs5963327 (OR 1.35, 95% CI 1.05–1.73, P = 0.017) and genotype A/A rs6610650 (OR 1.34, 95% CI 1.05–1.72, P = 0.020) were also associated with the risk of T2D development in women. The T-T-A haplotype, including minor alleles of the studied rs5917471–rs5963327–rs6610650 polymorphisms, was associated with an increased risk of developing diabetes mellitus in both men (OR 1.29, 95% CI 1.04–1.58, P = 0.022) and women (OR 1.27, 95% CI 1.02–1.58, P = 0.034). Patients with T2D had a significantly higher content of hydrogen peroxide in plasma compared to the control group (P < 0.05) regardless of sex, however, the relationship between rs5963327 and rs6610650 and the increased content of oxidized glutathione GSSG was found only in women. Thus, we detected for the first time the associations of rs5963327 and rs6610650 of the CYBB gene with the development of T2D and redox status of patients. The studied polymorphic variants of the gene encoding the beta chain of cytochrome b-245 of NADPH oxidase may contribute to a shift of balance in the redox homeostasis system towards the prooxidant status, characteristic of T2D.
Based on an exhaustive literature analysis and own observations, I proposed a hypothesis that glutathione deficiency is exactly the most plausible explanation for serious manifestation and death in COVID-19 infected patients. The major risk factors established for severe COVID-19 infection and relative glutathione deficiency found in COVID-19 infected patients with moderate-to-severe illness have converged me to two very important conclusions: (1) oxidative stress contributes to hyper-inflammation of the lung leading to adverse disease outcomes such as acute respiratory distress syndrome, multiorgan failure and death; (2) poor antioxidant defense due to endogenous glutathione deficiency as a result of decreased biosynthesis and/or increased depletion of GSH is the most probable cause of increased oxidative damage of the lung, regardless which of the factors aging, chronic disease comorbidity, smoking or some others were responsible for this deficit. The hypothesis provides novel insights into the etiology and mechanisms responsible for serious manifestations of COVID-19 infection and justifies promising opportunities for effective treatment and prevention of the illness through glutathione recovering with N-acetylcysteine and reduced glutathione.
Background. Imbalance in the system of redox homeostasis is an important link in the pathogenesis of type 2 diabetes (T2D). Gamma-glutamyl cyclotransferase is an antioxidant defense enzyme directly involved in the metabolism of glutathione, an endogenous antioxidant. The aim of the study was to examine the association of single nucleotide polymorphisms (SNP) rs38420 (GA), rs4270 (TC), rs6462210 (CT) and rs28679 (GA) in GGCT gene with the risk of developing T2D. Materials and Methods. The study included 1022 T2D patients and 1064 healthy volunteers. Genotyping of GGCT gene loci was performed using iPLEX technology on a MassArray Analyzer 4 genome time-of-flight mass spectrometer (Agena Bioscience). Results. As a result, we identified for the first time the association of SNP rs4270 in the GGCT gene with the risk of T2D in the Russian population. We have also established genetic and environmental interactions associated with predisposition to the disease: protective effect of gamma-glutamyl cyclotransferase gene was observed only in non-smokers under condition of daily consumption of fresh vegetables and fruits, whereas in persons with insufficient consumption of plant foods, as well as in all smoking patients protective effect of GGCT was not observed. In patients with T2D, the level of hydrogen peroxide and glutathione monomer was sharply increased compared to the controls. SNP rs4270 was also found to be associated with elevated levels of reduced glutathione in the plasma of type 2 diabetics. Conclusion. Thus, for the first time it was established that polymorphic locus rs4270 in the GGCT gene is associated with a predisposition to T2D, but its relationship with the disease is modulated by smoking and fresh plant foods consumption.
Background: Pancreatic beta-cell dysfunction, along with the insulin resistance of peripheral tissues, is a key element in the pathogenesis of type 2 diabetes (T2D). In this regard, of considerable interest is the study of the role of polymorphisms of the genes directly involved in the work of the beta cells of the islets of Langerhans in the formation of susceptibility to the disease. The aim of the study: To study the relationship of the polymorphic variant of the gene encoding insulin like growth factor 2 mRNA binding protein 2, IGF2BP2, (T>C, rs11927381) with the risk of developing T2D in the residents of the Kursk region. Materials and methods: The study included 559 patients with type 2 diabetes and 540 healthy volunteers. Genotyping of the IGF2BP2 gene polymorphism (T>C, rs11927381) was performed using iPLEX technology on a genomic time-of-flight mass spectrometer MassArray Analyzer 4 (Agena Bioscience). Statistical analysis was performed with the use of the online program SNPStats. Results: The frequency of the C/C genotype was significantly higher in the group of patients with T2D compared with the control group (OR 1.75; 95% CI 1.25-2.44; P=0.0026). The association retained its significance after adjustment for sex, age and body mass index (OR 1.87; 95% CI 1.26-2.78; P=0.0054). A gender-stratified analysis showed that the identified association was typical only for men (OR 2.27; 95% CI 1.17-4.40; P=0.041), while in women it was not observed (P>0.05). C/T and C/C genotypes were associated with a decrease in total cholesterol and low-density lipoproteins in patients with T2D (P<0.05). Conclusion: The established association indicates the involvement of the IGF2BP2 gene in the formation of susceptibility to T2D. The studied variant rs11927381 is also associated with lower levels of total cholesterol and low-density lipoproteins in type 2 diabetic patients that may account for the SNP effects on epigenetic markers, such as methylation and acetylation.
Chronic hyperglycemia results in oxidative stress that has been implicated as the underlying cause of all DM complications. The glutathione-S-transferases (GSTs) are antioxidant enzymes that catalyze the conjugation of reactive oxygen and nitrogen species to glutathione. The present work aimed to study the effect of the genetic polymorphisms of the GSTM1, GSTT1 and GSTP1 genes on the risk of developing type 2 DM in Kursk population. The study groups included 321 patient (mean age 59,31±9,23) with type 2 DM who were admitted to the endocrinological department of Kursk Emergency Hospital from January to October 2016, and 330 age-and sex-matched healthy subjects (mean age 59,49±8,14). Genotyping of deletion (del) polymorphisms of GSTM1 and GSTT1 genes was performed by multiplex PCR with subsequent analysis of the amplification products using electrophoresis on a 2% agarose gel with ethidium bromide and visualization of results in UV light. Genotyping of GSTP1 Ile105Val polymorphism was performed by PDAF, PCR, real-time discrimination of alleles using TaqMan probes. There was no difference in genotype distribution among type 2 DM and control subjects in GSTM1 and GSTT1 genes (р0,05). Significant differences between the genotype frequencies for the GSTP1 105Ile/Val and GSTP1 105Val/Val polymorphisms were observed in diabetic patients (51,09%) as compared to controls (42,82%), (OR 1,39, 95%CI 1,02-1,90, р=0,03). The same association of genotypes GSTP1 105Ile/Val and GSTP1 105Val/Val was found in diabetic females (OR 1,59, 95%CI 1,07-2,38, р=0,02), whereas diabetic males showed greater frequency of the GSTT1 del/del genotype (OR 2,13, 95%CI 1,07-4,24, р=0,02). We observed a significant association of the double combinations GSTM1+ GSTP1 105Val/Val (OR 2,62; 95%СI 1,01-6,84, р=0,04) and GSTТ1del/del GSTP1 105Val/Val (OR 4,82, 95%СI 1,21-19,10, р=0,02) with the risk of type 2 diabetes mellitus development. The established associations indicate the involvement of polymorphisms of glutathione-S-transferases in the formation of predisposition to T2DM and confirm the significant role of disturbances in antioxidant defense system in the pathogenesis of the disease.
Impairments of redox homeostasis play a key role in the development of type 2 diabetes mellitus (T2D). The main endogenous source of the superoxide radical is NADPH oxidase, one of the subunits of which is the light chain of cytochrome b-245, CYBA. The aim of the study was to study the associations of cytochrome b-245 alpha chain gene polymorphisms rs7195830 (G>A), rs8854 (C>T), rs9932581 (C>T) and rs4673 (G>A) with a risk of developing T2D. The study included 1022 patients with T2D (average age 61,1 ± 7,2 years) and 1064 sex-and age-matched healthy volunteers. Genotyping of CYBA gene polymorphisms was performed using iPLEX technology on a MassArray Analyzer 4 genome time-of-flight mass spectrometer (Agena Bioscience). The CYBA gene A/A genotype (rs4673, G>A) was associated with an increased risk of developing the disease (OR 1,49, 95%CI 1,111,99, P=0,0074, recessive model). The identified association remained significant even after the adjustment for gender, age, and body mass index (ORadj 1,51, 95%CI 1,09-2,09, padj=0,014). Gender-stratified analysis revealed that the established association rs4673 was characteristic only for females (ORadj 1,60, 95% CIadj 1,04-2,46, padj= 0,032). Patients with T2D had a significantly higher level of hydrogen peroxide in blood plasma compared with the control group (p<0,05), regardless of gender, however, the relationship between the A/A genotype rs4673 with the increase in the content of Н2О2 in plasma by 0,77 mmol/L (p = 0,044) was found only in males. The T/T genotype rs9932581 was associated with an increase in glycated hemoglobin level of 2,71% (p = 0,042) in the general group of patients with T2D, as well as with an increase in the same indicator by 4,44% (p = 0,03) among females. The association of the C/T genotype rs9932581 with an increase in the proportion of HbA1c by 0,61% (p = 0,018) and with an increase in blood glucose level by 1,06 mmol/L (p = 0,029) was noted exclusively in males. The association of fasting blood glucose level was also established with genotype A/A rs7195830, in which carriers the glucose concentration was 1.17 mmol/L higher than in homozygotes for the reference allele (P = 0,022).
In the study, which included 579 patients with type 2 diabetes and 542 healthy individuals, for the first time in the Russian population, an association of polymorphism rs11827381 of the IGF2BP2 gene with an increased risk of developing the disease was established. However, the association of variant rs11827381 with an increased risk of developing type 2 diabetes was observed solely in smoking patients and was not detected in non-smokers. Bioinformatics analysis revealed that transcription factors, which binding sites appear in the presence of the C allele, differ from the spectrum of transcription factors specifically associated with the reference T allele and are involved in the regulation of the biosynthesis of ketone bodies, as well as the cellular response to glucocorticoid hormones. The results indicate the trigger role of smoking in the relationship of the polymorphic variant rs11827381 of the IGF2BP2 gene with the development of type 2 diabetes.

domain: biology


- Quinnipiac volleyball falls to Rider in annual Dig Pink game
- Quinnipiac volleyball rolls past Saint Peter’s in three sets
- Quinnipiac women’s soccer finishes even with Marist on Senior Day
- Quinnipiac men’s ice hockey upsets No. 18 Boston College, 1-0
- No. 25 Old Dominion tops Quinnipiac field hockey, 3-0, on Senior Day
- Quinnipiac men’s soccer comes back to beat Rider, 2-1
- Quinnipiac men’s ice hockey wins home opener against UConn
- Parents Speak Up
- A college actor’s ‘dream’
- GSA seeks allies
All posts tagged "Alex Whelan"
Quinnipiac men’s ice hockey 2018-19 preview
The Quinnipiac men’s ice hockey team’s 2017-18 season did not go as planned. It’s not much of a debate. The stats are there to prove it. The frustration was visible all season. And frankly, the turnover of...
- Posted October 2, 2018
Quinnipiac men’s ice hockey strikes first in series, beats Yale 5-1
For the first time since the 2005-06 season, the Quinnipiac men’s hockey team took to the road to start the playoffs and it started off its best-of-three first round series against Yale with a 5-1 win. “I...
- Posted March 3, 2018
Duel in the desert
It wasn’t all too long ago that Quinnipiac was new to Division I ice hockey. When the then-Quinnipiac Braves joined the MAAC and became a Division I program in the 1999-00 season, they played out of the...
- Posted January 23, 2018
Quinnipiac men’s ice hockey swept by UMass Amherst
It’s no secret anymore. The Quinnipiac men’s ice hockey team is truly in a slump and can’t seem to shake it off, as it lost both games of a home-and-home against out-of-conference opponent UMass Amherst. On Saturday,...
- Posted November 25, 2017
Cait’s Column: Smith’s impact larger than just on-ice stats
“He’s a goal scorer.” Head coach Rand Pecknold stated the obvious when asked about senior forward Landon Smith’s impact during his time at Quinnipiac, following the men’s ice hockey team’s 3-2 overtime win at Northeastern. It’s no...
- Posted October 24, 2017
No. 18 Quinnipiac outlasts No. 14/16 Northeastern for 6-4 victory
No. 18 Quinnipiac men’s ice hockey scored six goals on 15 shots to beat No. 14/16 Northeastern, 6-4 on Friday night at Matthews Arena in Boston. After a nightmare first two periods, — which saw Quinnipiac go...
- Posted October 21, 2017
No. 14 Quinnipiac men’s ice hockey loses 3-2 in final seconds to No. 2 Boston University
The No. 14 Quinnipiac men’s ice hockey team (0-1-1) lost its home opener in overtime, 3-2, on Sunday, as it failed to upset No. 2 Boston University (2-0-0). “I thought played hard today,” Quinnipiac head...
- Posted October 8, 2017
No. 14 Quinnipiac men’s ice hockey ties No. 13 Boston College in season opener
In its first game of the regular season No. 14 Quinnipiac men’s ice hockey played to a tie against No. 13 Boston College at Conte Forum. Aside from the constant back-and-forth play, it was a clear battle...
- Posted October 7, 2017
Chase Priskie named 2017-18 men’s ice hockey team captain at banquet
Quinnipiac men’s ice hockey held its annual end-of-the-season banquet on Saturday night as head coach Rand Pecknold announced award winners and captains for the 2017-18 season. Sophomore Chase Priskie was named the lone captain for next season,...
- Posted April 25, 2017
No. 19 Quinnipiac ready for Lake Placid
In a rematch of last season’s ECAC Hockey championship game, fifth-seeded (nationally-ranked No. 19) Quinnipiac men’s ice hockey is set to play top-seeded (nationally-ranked No. 2) Harvard in this year’s ECAC Hockey semifinals. So far in the...
- Posted March 16, 2017
Men’s ice hockey team takes Game 2 at St. Lawrence
Quinnipiac men’s ice hockey lives to see another day after beating St. Lawrence 3-2 in Game 2 of the ECAC Hockey Tournament Quarterfinals best-of-three series. Quinnipiac had goals from freshman Alex Whelan and sophomore Craig Martin, while freshman...
- Posted March 11, 2017
Men’s ice hockey team routs Brown in first game of playoffs
Quinnipiac men’s ice hockey showed no mercy in its first playoff game of the season. The Bobcats beat Brown, 6-1, and outshot the Bears, 46-20, behind goals from six different skaters at High Point Solutions Arena on...
- Posted March 3, 2017
Men’s ice hockey takes 3-2 win over UMass despite power-play woes
No. 6/7 Quinnipiac men’s hockey defeated the University of Massachusetts Minutemen 3-2 on Tuesday at High Point Solutions Arena in Hamden. While the win improves the Bobcats’ record to 4-2-1, head coach Rand Pecknold saw a few...
- Posted October 25, 2016


Rudeboy (PSquare) – Nkenji Keke
One Part of PSquare Rudeboy is out with a brand new single titled “Nkenji Keke”. Its now obvious that rumoured split between the twins is now fully enforced.
Listen and share your thoughts below
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Via The Globe and Mail: H1N1 fears spur extra flu vaccine demand. Excerpt:
Canada will ship out more influenza vaccine this season than it has since the H1N1 pandemic swept the country four years ago, with nearly every province and territory placing late-season orders to satisfy a surprising surge in demand for the flu shot.
The 2013-2014 season marks the first time since the pandemic that Canada has been forced to track down extra vaccine, above and beyond a five-per-cent cushion built into the country’s contracts with vaccine makers, according to the Public Health Agency of Canada.
“With this season – for whatever reason and we can only theorize – but there has been a lot more uptake, a lot more demand by Canadians,” said Dr. Gregory Taylor, Canada’s deputy chief public health officer.
Only Nova Scotia and Nunavut declined to snap up more vaccine when Ottawa secured more than 400,000 extra doses earlier this month, according to an informal survey by The Globe and Mail.
Newfoundland and Labrador increased its vaccine supply by the largest amount – 62 per cent – by requesting an extra 80,000 doses on top of the 130,000 it ordered at the start of the influenza season. Saskatchewan and Manitoba were not far behind, increasing their stockpiles by 53 per cent and 29 per cent, respectively.
Canada had already ordered approximately 10.8 million doses at the start of the season, about the same size of the order it placed at the beginning of the 2010-2011 season and more than any year since, according to the Public Health Agency of Canada (PHAC).


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Cairo CornStalk Festival June 25, 2016
June 25, 2016 @ 8:00 am - June 26, 2016 @ 1:00 am
“Boots, Chaps & Cowboy Hats” is the theme for this year’s CornStalk festival. Watch this page for all the events that will be going on. Some include a community parade, Fireman obstacle course, Fun Run, turtle races, kids games including a petting zoo and inflatable, baseball games, free swimming, beer garden and a dance at the tennis courts featuring “Bases Loaded”. We are also planning a Centura all school reunion.
Parade Entry Form[gview file=”https://cairocommunity.com/wp-content/uploads/2016/04/parade-entry-2016.docx”]
Vendor Form[gview file=”https://cairocommunity.com/wp-content/uploads/2016/04/Vendor-Letter-2016.docx”]

domain: entertainment


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Drs. Jane O’Halloran, MD, PhD and Rachel Presti, MD, PhD discuss the in-patient randomized clinical trial studying the possible treatment effects of antimalarial medication chloroquine and hydroxychloroquine . Drs. Eric Lenze, MD and Caline Mattar, MD discuss the outpatient randomized clinical trial using fluvox to study the potential mitigation of severe symptoms.
ShowMe the Science PodCast as featured in the School of Medicine Release

domain: medical


text:
Fire up the grill and make these mouthwatering cheeseburgers that are teeming with robust, savory flavors. There’s chipotle, bacon, mayo and Sargento® Sharp Cheddar Cheese. Add juicy tomatoes, a nice bite of red onion and crisp lettuce if you please.

- 1-1/2 pounds ground beef
- 1 Tbsp. minced chipotle in adobo
- 3 Tbsp. chopped cilantro
- salt and pepper to taste
- 8 pieces cooked bacon
- 2 tomatoes, sliced
- 1 small red onion, thinly sliced
- 2 cups shredded lettuce
- 4 slices Sargento® Sliced Sharp Cheddar Cheese
- 1 Cup Mayo
- In a medium mixing bowl add the ground beef, minced chipotle chili, chopped cilantro and season with salt and pepper.
- Divide the meat into 4 patties. Then set aside.
- Place the burger patties onto the grill and cook for 5 minutes on each side for medium rare.
- Remove from grill then, top patties with cheddar cheese. Meanwhile, toast the bun and spread chipotle aioli on one side then top with lettuce, tomato, onion, burger patty and 2 pieces of bacon.

domain: food


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Miramalfi is a dated hotel with magnificent views. When we arrived we found out the pool and beach were closed. The restaurant was also closed and the shuttle bus into town was not operating. The air conditioning appeared not to be working. The rates were not reflective of 60 % of services not operating due to the season.
The staff were indifferent at best and we waited 1/2 hour in the bar without service until finally we searched for someone who could serve drinks.
The gentleman who showed us the beach and pool we couldn't use was quite delightful.
The was no information in the rooms in terms of local operating times for shops, restaurants or tour operators, so it was very much trial and error, especially the first night when because of the unfamiliar surroundings we could not find a restaurant which was open and the hotel were quite clear in not helping us. The road into town is quite scary especially at night for the uninitiated, and is not suggested for anyone with a mobility restriction.
At no time were we asked if we were enjoying our stay or given any suggestions for local activities.
We were not shown how to use any facilities in the rooms including the shutters which we accidentally found on the last day. The rooms become unbearably hot in the mornings and to have known about the shutters would have ensured some level of comfort
We asked reception to confirm our arrival in Rome and a flight to Spain but no assistance was forthcoming.
Television reception and wifi intermittent.
Our passports were held for the duration of the stay rather than copied and were the not returned in due course at checkout. Fortunately our transfer driver was notified and retrieved them for us.
A serene disinterest in the guests with elevated price tag.
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Hotels.com, Venere, Despegar.com, EasyToBook and Tingo so you can book your Miramalfi Hotel reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Miramalfi Hotel Amalfi

domain: travel


Now hold on—-how many roads are there in this picture? Our Photo of the Day sure is an imaginative and different take on the term “crossroads.”
This double exposed image is the offspring of a Kodak E100VS film swap between ultra-talented community members gocchin and hodachrome. Gocchin took a photo with a Lomo LC-A+ in Honk Kong and hodachrome shot his part of the bargain in Japan. You can find more of this dynamic duo’s combo shots in the album *Miracle Filmswap- Hodachrome and gocchin.* Brace yourself. The photos are astounding.
Congratulations to *gocchin* on his impressive shot that made it as our Photo of the Day.
We’re fizzing with excitement to introduce our latest Kickstarter project: the Lomo’Instant Square. We’re talking about the world’s first analogue camera to produce square-format Instax pictures. It features a 95mm glass lens for super sharp photos, an advanced automatic mode that takes care of exposure, all of Lomography’s signature creative features — and a compact, foldable design. The Lomo’Instant Square has launched on Kickstarter. Come join the fun and back us on Kickstarter now to save up to 35% on the planned retail price, and scoop all sorts of extra treats. Be sure to snatch up the deals before they run out. Be there and be square!
Contrary to popular belief, photo editing has been around since the early days of photography. The only difference is it's been used sparsely. There' a reason why the majority of old photographs are more appealing.
This travel story re-imagines my brief stop at the Frontier Bar in Dunkirk, Montana in 1957. I photographed images found on the internet to reconstruct a visual context of our road trip, as all the negatives and color slides are lost.
Australian fine art photographer Chris Round thinks that photography is a remarkable medium and "there are so many different ways in which it can be used." Read more into his insight and see his photos in this interview.
Although many elements are what make up a picture, to produce a sublime landscape photograph is a hit-and-miss; personal style is the dictator. And this is how formation and colors are what make up the diverse landscape pieces of photographer Luca Tombolini into paintings.
After the Second World War, society learned that there are many things needed to be changed by the way authorities run their businesses -- from employers, high society, and politicians. This the incomplete history of protest, from the 1940's to now in art and photographs.
The TEN AND ONE Annual Lomography Photo Awards is made up of 11 different categories. Through these 11 different categories — 10 unchanging and one modified every year to reflect contemporary global issues — we’re asking to see the world through your eyes and to share your experience as a human on this beautiful, bizarre and bewildering planet. Be mesmerized by these moody black and white photographs that took the top spot in our Monochrome category.
Because the warmth of the sun is upon us once again, we're pretty sure many of you are already planning to head out of town or wherever. Here's an immediate checklist for your next Lomographic adventure.
There is a well-known saying: "It's not about the destination; it's about the journey."Although we do agree on this matter, sometimes it truly is about both of these things. Over the years, we have been writing about many beautiful destinations, and we have pictures to prove it.
The TEN AND ONE Annual Lomography Photo Awards is made up of 11 different categories. Through these 11 different categories — 10 unchanging and one modified every year to reflect contemporary global issues — we’re asking to see the world through your eyes and to share your experience as a human on this beautiful, bizarre and bewildering planet. Witness how photo experiments and happy accidents can produce striking, one-of-a-kind photographs.


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|NOTES||Use for contemporary sculptural works that are composed of figures and objects arranged into a picturelike scene, which the viewer does not enter. For works that create surroundings that the viewer can enter, use "environments (sculpture)." For the silent, immobile arrangements of one or more costumed performers to reproduce a scene from art, drama, literature, history, or the imagination, use "tableaux (performances)."|
|HIERARCHY||Objects Facet>Visual and Verbal Communication>Visual Works>visual works (works)>sculpture (visual work)>tableaux (sculpture)|
Search works with
Search for works of art which specifically
contain the subject "tableaux (sculpture)" subject or works within the subject tree Infobox:
equal to "tableaux (sculpture)" or that is a sub-subject of "tableaux (sculpture)"
Searching the subject tree for "tableaux (sculpture)" would return results containing subjects like:
tableaux (sculpture) (with subject tree: Objects Facet>Visual and Verbal Communication>Visual Works>sculpture (visual work)>tableaux (sculpture))

domain: artistic


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Springfield Public Schools High School students created holiday cards under the theme of diversity.
Julie Jaron, Director of Visual & Performing Arts for SPS, explains, “They were to draw a scene that reflects the many faces and cultures of Springfield Public Schools students and the various joyous ways they celebrate the holiday season.”
Each High School submitted one holiday card. Exploring their creativity, the final pieces feature a landscape, holiday ornaments, city hall and the earth.
Superintendent Daniel Warwick says this year’s theme is particularly fitting for SPS were students have roots in various countries around the world, including Africa, Latin America, Asia, and so many other places.
“It’s clear the students really reflected on the theme of diversity and it’s been a delight to see their creativity expressed in so many unique ways,” said Warwick.
Reflecting on the richness of diversity, Ashley Ortiz, a junior at Commerce High School said, “My idea was to make a card to reflect how in the world there isn’t just one face- there are many of them and that’s what makes the world beautiful and brings us together.”
Other students who submitted art include: Bree Davis, Springfield High School of Science and Technology, Tiffany-Amber, Springfield Central High School, Pedro Acevedo, Springfield Public Day High School, Samantha Clinton, Roger L. Putnam High School.
For images of the student’s art work featured in the holiday cards and their photos, visit: www.sps.springfield.ma.us/pressroom/

domain: news


text:
Important: Please inform your server of any food allergies. Consuming raw or undercooked meats, poultry, seafood, shellfish or eggs may increase your risk of foodborne illness. Gluten-free and dairy free options available for most menu items. Please ask your server.
Our Small Plates are sized to share, a few bites each for two to three people
Loaded Greek Hummus
Spinach Artichoke Dip
Pork & Beef Meatballs Pizzaiolo
Garlic Butter Shrimp
The CQ Melt
Mac & Cheese
Antipasti, Boards & Cheese
Antipasti and Cheese Boards are, like the small plates, good for a few people to sample from
Our Flatbreads are about 9”, enough for two to share or for one to have as a meal.


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Artyom Sidorkin, a 28-year old Russian, went into the hospital complaining of chest pain. After some x-rays, doctors were convinced they'd found a tumor in his lungs. When they went in to remove it, they found a 5 centimeter fir tree. Not a branch. A tree. Not in his stomach. In his lungs. Turns out he'd been coughing up blood because pine needles were stabbing his capillaries.
This is the best part...the doctors believe "that the patient might have inhaled a small bud, which then started to grow inside his body." [source]
What. The. Frak.

domain: health


The health, safety and well-being of the employees and community members we serve is top priority for the Thurston County Prosecuting Attorney’s Office (PAO). From 8:30 A.M. through 4:30 P.M., Monday through Friday, the PAO main office in Courthouse Building 2 will remain open and staffed for essential work and to serve critical needs. The office will close daily between noon and 1:00 P.M. to allow our staff to take a lunch break.
To help you avoid unnecessary trips to the courthouse, we are advising that members of the public first contact the PAO at 360-786-5540 or email@example.com
to see if their matter can be resolved over the phone. Our office is currently operating at limited capacity and we appreciate your patience and understanding as we work to address your needs.
Please review the information provided below to evaluate how recent changes related to the COVID-19 response may impact your business with our office.
If you have received a subpoena from the PAO:
Effective March 17, 2020, Thurston County District Court has suspended all currently scheduled jury trials. Trials will be rescheduled, and witnesses notified when new dates are set.
Thurston County Superior Court has suspended all jury trials scheduled through July 6, 2020. If you have a subpoena for a trial between now and July 6, 2020, please disregard that subpoena. When a new trial date is set, witnesses will be notified.
Support for Victims:
Many victims are understandably experiencing heightened levels of anxiety about their cases during this rapidly changing situation. PAO Advocates are primarily attending community meetings via Skype and Zoom, and many meetings with victims are being conducted telephonically. Victims can call (360) 786-5540 to speak with a victim advocate. Hours of operation may be limited but messages will be checked as often as possible. Many court hearings that were previously scheduled are being cancelled and rescheduled. Advocates are doing their best to continue to notify victims of these changes.
We remain committed to the victims and survivors we serve.
Most Thurston County Courts are limiting calendars and many hearings will be continued. If you are planning to attend a court hearing, avoid an unnecessary trip to the courthouse by calling the PAO first to confirm the hearing is in fact still taking place.
Superior Court Updates:
Effective June 1, 2020, Thurston County Superior Court will be open Monday through Friday, 8:00 A.M. until 5:00 P.M. Family and Juvenile Court will also be open Monday through Friday, 8:00 A.M. until 5:00 P.M.
You can find a list of actions being taken at the Thurston County Courthouse and Family and Juvenile Court at https://www.thurstoncountywa.gov/sc
. For questions regarding Superior Court cases, please contact (360) 786-5560.
District Court Updates:
Based on recent changes in the COVID-19 situation and the issuance of resolutions by the Thurston County Board of County Commissioners and the Thurston County Board of Health, the Courts have implemented operational changes.


text:
We are very pleased to publish the latest classic & custom car show entry forms which you find on the following link. If you are applying from a club then please complete the form you will find on this link.
Last year we had over seventy classic cars on display at the Ferndown Fete and similar to last year we are opening up the show to owners of customised cars as well. Our aspiration is to turn this part of the fete into one of the south’s biggest & best classic and custom car shows. Visitors are very welcome to take a look and to wander round the car and club displays. There is always a great atmosphere with lots of enthusiastic owners who would be very happy to talk to you about their own pride and joy.
We very much look forward to seeing you all on June 23rd 2018.

domain: hobby


text:
"Thanks everyone. I took the day off work and just had a nice day.
Question for you parents of doodles: Does the snow ball up on the bottoms of their paws, and if so, what do you do about it? Booties?"
I am a first time puppy owner. Our only other dog was a border collie/Australian Shepherd mix and was a rescue at age 2. Puppydom is new to me.
What Type of Doodle(s) do you have? What are their names? Tell us about your doodle(s) or any other pets you have!
Aussiedoodle. Her name is Pippi. She is a red tricolor 14 week old Aussiedoodle. Actually, I am not sure if she is a tricolor or a parti. She has two shades of red and white. Her dam is a true red tricolor miniature Australian Shepherd; her sire is a mini white poodle.
Where did you get your doodle(s)?
Why did you choose a doodle rather than another breed or mix?
We love Aussies and Border Collies, but wanted a "non-shedder."
What are Your Favorite Things to Do With Your Doodles?
After just having her 2 weeks, we are still learning things to do, but the running in the yard is great.!
Update: 6 mos. old now. She loves to run circles and long walks. She brings us her chosen toy of the moment and wants to play fetch. She has completed puppy kindergarten with us and we are planning to go to Adolescent Antics next, then maybe beginning Agility....?
Does your doodle(s) shed?
Who grooms your doodle(s)?
Me most of the time.
Favorite Doodle Products?
still looking for a product that leaves her hair shiny....

domain: pet


text:
Dangers of Misdiagnosing Mental Illness While Abusing Drugs
- Kate Pindera
- 6 Aug 2020
Mental illness is a leading cause of disability in Canada, with 1 in 2 Canadians having (or have had) some form of mental illness by the time they reach their 40s.
Unfortunately, mental illness misdiagnoses are also disturbingly common, hindering people struggling with clinical depression, bipolar disorder, and other types of psychiatric problems from achieving healing and wellness.
In this article, we’ll discuss the prevalence of misdiagnosed mental illness, why it happens, and the heartbreaking effects it has on someone struggling with drug abuse.
People Wait 13 Years for Correct Bipolar Disorder Diagnosis
A 2012 survey by the Guardian reveals that individuals with bipolar disorder had to wait, on average, 13.2 years before they received a correct diagnosis. Out of 706 respondents surveyed, only 15% received a prompt diagnosis, while 85% experienced a diagnostic delay and potentially mental illness misdiagnosis, spending years getting treatment for the wrong prognosis.
The majority of the participants were erroneously told they had depression and reportedly felt that their symptoms got worse after being prescribed medications, such as antidepressants and sleeping aids, which were incompatible to their actual disorder.
“A delay of this length has a significant impact for individuals and families, with sometimes devastating consequences, as bipolar has the highest rate of suicide of any psychiatric illness,” Suzanne Hudson, the chief executive of Bipolar UK, told the Guardian. Her organization conducted the research in collaboration with the Royal College of Physicians and Bipolar Scotland to raise awareness on the pervasiveness of delayed diagnosis for mental health disorders.
Aside from bipolar disorder, other commonly misdiagnosed mental illnesses include depression, schizophrenia, and attention-deficit hyperactivity disorder (ADHD).
The Negative Impact of Misdiagnosed Mental Illness
A misdiagnosed mental illness can trigger a cascade of adverse consequences, impeding the affected individual’s quality of life and endangering their safety. The following are some negative effects of misdiagnosed mental illness:
Inaccurate Treatment Equals Ineffective Treatment
A mental health misdiagnosis will inevitably result in an incorrect treatment strategy. In some cases, it may have no effect at all. But in a worst-case scenario, wrong treatment plans can produce devastating drug side effects, which may aggravate existing symptoms and eventually worsen the person’s mental illness.
Feelings of Frustration
A patient with a misdiagnosed mental illness can end up feeling confused, frustrated, and deflated when they realize that the prescribed course of treatment doesn’t seem to work. They may develop negative thoughts that they are a failure or a hopeless case, which, when left unaddressed, can potentially lead to unhealthy coping mechanisms, such as a dependency on alcohol and drugs, or worse, self-harm and suicide.
Heightened Risk to Self-Medicate with Substances
Mental health problems and substance use disorders are closely related. The Centre for Addiction and Mental Health reports that at least 20% of people with a mental illness have a co-occurring substance use problem. Similarly, over 15% of people with a substance use problem have a co-occurring mental illness. It’s primarily because drugs and mental health disorders share similar contributing factors, including genetic roots and environmental triggers.
However, the issue of mental illness misdiagnosis and the failure to get access to adequate psychiatric treatment for these conditions also play a critical role in concurrent disorders. While some individuals become addicted to harmful substances out of societal pressure and curiosity, people with mental illness are at higher risk of falling into the traps of substance abuse out of a desire to feel better. In search of something to ease the pain or mask the symptoms of their mental disorders, they self-medicate by abusing alcohol and other illicit drugs. Cocaine, marijuana, and opioid drug addiction are prevalent because of their ability to bring you to a state of euphoria and offer an escape from the bleak reality of having a misdiagnosed mental illness.
Self-Harm and Suicide
About 4,000 Canadians per year die by suicide—an average of almost 11 suicides a day, affecting people from all walks of life.
Cases of self-harm and suicide are at staggering rates in people who have co-occurring mental illness and substance abuse disorders. Both are clear indications that an individual is in dire need of better coping skills. Many mental illnesses linked to self-harm and suicide include borderline personality disorder, depression, eating disorders, anxiety or post-traumatic stress disorder (PTSD).
Many influencing factors can trigger the urge to hurt oneself or take one’s own life, but it usually involves an overwhelming pain, anger, or frustration. Sadly, people with misdiagnosed mental illness are more vulnerable because the symptoms of their psychiatric condition are intensified due to substance abuse as well as a lack of treatment or out of their predicament’s hopelessness.
Why Are People Misdiagnosed?
Unlike other medical conditions, there are still limited tests and biomarkers available to identify specific mental health disorders definitively. Clinicians rely heavily on physical evaluation and patient history information provided during consultations. This includes:
- Medical history
- Family’s background, if any first-degree relatives have been diagnosed with drug and mental health problems
- All symptoms experienced presently and in the past
- Observations from previous doctors
- Sensitive information on trauma or abuse, which may have contributed to the condition
Finding out this information requires ample time and a connection between the medical provider and the patient to tease out these specific details. Frequently, limited consultation time is not enough to achieve this, and patients may be hesitant to reveal everything during the initial meeting. For instance, the patient may not mention that he is in the habit of abusing alcohol or turning to drugs to reduce his symptoms, which is a piece of crucial information that could have resulted in a dual diagnosis treatment.
Doctors may be inclined to offer a prognosis based on insufficient patient history, leading to misdiagnosed mental illness, especially if no follow-up appointment occurs, and there’s no chance to review and update the initial findings.
Recovering From Mental Illness & Addiction
Freedom From Addiction offers an extensive range of treatment programs that delves into mental health problems, such as anger management and cognitive behavioural therapies, to improve their coping skills without turning to drugs or alcohol.
If you suspect that you or a loved one is suffering from a misdiagnosed mental illness, please don’t hesitate to contact us. A member of our team will get back to you shortly.
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text: Columnar Falls is another one of those small but beautiful waterfalls that pepper the Northwest Landscape. A short hike brings you to a creek tossing itself over the lip of a ledge. The waterfall fans out over a wide wall and follows the cracks in the rock down through the moss. At places, the streams of water plunge straight to the bottom. In others, the water follows the cracks down diagonal routes. Given the short hike, it probably sees heavy traffic on the weekends but on a Monday afternoon, I had the entire view to myself.

domain: geography


text:
Publications of C M Stanton
XANES and EXAFS investigation of sd hybrid bonds in alloys of gold with gallium, germanium and tin through the solid-liquid transition
The XANES for the Au LIII edge in solid Au and AuGa alloys have been measured using synchrotron radiation. The excess white line areas in the alloys have been compared with the same region of pure Au to give the d-state charge transfer from Au to Ga. It is in good agreement with values published for an AuAl alloy. Backtransfer for s-electrons from Ga to Au is evident from X-ray photoelectron spectroscopy and confirms an sd hybrid bond in this alloy system. On melting, this bond persists in the molten state, but with diminished effect which is evident from the reduced coordination number obtained from EXAFS. A similar bond is found in molten AuSn, but not in an AuGe alloy. © 1993.

domain: literature


text:
Description: The Rectory
Date Listed: 12 August 1981
English Heritage Building ID: 295421
OS Grid Reference: TQ5624301411
OS Grid Coordinates: 556243, 101411
Latitude/Longitude: 50.7912, 0.2154
Explore more of the area around Willingdon and Jevington, East Sussex at Explore Britain.
JEVINGTON THE STREET
TQ 5601 40/26
C18. Two storeys and attic. Red brick. Hipped tiled roof. Originally
5 windows, but to the left half of the front a large bay of 3 windows has
been added, making 6 windows in all. Round-headed window in centre of first
floor. Glazing bars intact, except on ground floor of bay. Porch added
contemporaneously with bay. Sides faced with flints.
Built of flint with stone dressings and tiled roofs.
Listing NGR: TQ5624301411
Source: English Heritage
Listed building text is © Crown Copyright. Reproduced under licence.


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Winter is creeping in isn’t it? And with that, sadly, comes bugs for us and our dogs. So, what can you do when they have a slightly sicky tummy?
Maybe try some bone broth! You can make it at home (though warning, it’s a great plan to make this ahead of time and freeze it!), it’s packed with good things and your dog will love it! It’s basically gravy – and what dog isn’t going to (literally) lap that up?
There are lots and lots of recipes, but here’s the one I’m using:
PREP TIME: 15 mins
COOK TIME: 24 hrs
– 3 turkey wings
– 4 medium carrots
– 4 stalks of celery
– 45ml of apple cider vinegar
– 4 black peppercorns
– 1.25l of water
– Slow cooker (or heavy crock pot, so long as you’re able to watch it)
– Freezer bags
– A hungry puppy!
1 – Add the turkey wings to the slow cooker,
2 – Roughly chop the celery and carrots, add to the slow cooker,
3 – Add the apple cider vinegar and the peppercorns,
4 – Add water (This may not work quite so well for your slow cooker – the ingredients should be just covered by water)
5 – Turn on the slow cooker and leave for at least 24 hrs (but monitor the water level if leaving it for longer)
6 – Extract the bones and feed or freeze (when cool)!
And Presto! I don’t know about you, but that doesn’t look half bad to me… and you can store it for up to about 3 months if you freeze it!
TIPS TO GIVE YOUR BROTH A BOOST:
1 – I like to boil it down and make a very concentrated broth, which I freeze and water down when I want to use it.
2 – You can do this with bones from your roast dinner, be they beef, lamb, chicken or anything else.
3 – Try and make sure that the apple cider vinegar you buy include ‘mother’. Mother is a rich, health-boosting natural protein. It has lots of healthy bacteria and acetic acid in it too, which will give your dog a great boost.
4 – You can also include all sorts of other vegetables! Nettle, alfalfa, spinach, kale or any veg going spare in the fridge – even my green-food-averse boy will eat it when it’s been stewed for that long.
5 – In the summer, you can put it in ice cube trays and freeze them for gravy-pops!
I’m not suggesting this will fix all ails and that you shouldn’t go to the vets – but think of this as super food for your dog! To give them all the goodness that they need to get their tummy back on track.
Or you can serve as an awesome replacement meal as a special treat!


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As Democrats continue to circle the wagons to preserve gun-free zones, Representative Mike Thompson (D-CA-5th Dist.) is suggesting gun owners support protecting children with background checks, which did not stop Adam Lanza from committing his heinous crime at Sandy Hook Elementary School.
Thompson reminds Americans of the day the Sandy Hook massacre broke Americans’ hearts. What he does not mention, however, is that Sandy Hook was a gun-free zone. He also does not point out that we have had background checks since the mid-1990s, yet they did not prevent Lanza from carrying out his horrible crime.
Nevertheless, writing in Politico Magazine, Thompson says, “Gun owners should support background checks.” And his idea of supporting background checks is extending places in which these checks are conducted to include gun shows and “sales … over the Internet.”
Two important points: 1. Adam Lanza did not get his guns from a gun show or over the Internet, so background checks at gun shows or the Internet would not have stopped him. 2. Every retail gun purchase over the Internet already goes through a background check. For example, if you live in Idaho and buy a gun from a gun dealer in Florida, that gun ships from a Federal Firearms License (FFL) holder in Florida to an FFL in Idaho. When the FFL from Idaho calls to say that your gun has arrived, you have to go to the FFL and pass a background check before he can give you possession of the gun.
That is the law.
The only Internet sales that do not require background checks are not actually sales at all; they are classified advertisements like those found in newspapers. Gun control proponents use the language of Internet sales to cover Internet classified advertisements because it allows them to expand background checks to sales that are not truly Internet-based, and it opens the door for them to expand background checks for Internet-based classifieds to classifieds in newspapers.
This is the slippery slope the NRA is fighting against when they oppose the kind of legislation Senator Joe Manchin (D-WV), Gabby Giffords, Mark Kelly, and now, Representative Thompson are pushing.
Adam Lanza stole his guns, which allowed him to easily circumvent our background-check system. Yet Thompson claims extending background checks to gun shows and Internet sales is “the best thing we can do to reduce gun violence while also protecting the constitutional rights of law-abiding Americans who own firearms.”
If Thompson really wants to do the “best thing,” he should trade this gun control campaign for a concerted effort to do away with gun-free zones in this country. The Constitution empowers and protects an armed citizenry; gun-free zones turn that same citizenry into sitting ducks.
Follow AWR Hawkins on Twitter @AWRHawkins. Reach him directly at email@example.com.

domain: law


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Located in a private, gated community, this secluded beachfront condo is a paradise for beach lovers nestled between lush, vegetation and the warm, turquoise waters. This beautiful two bed, two bath vacation home is a single story condo on the development’s second floor. The owner of this unit will enjoy access a spacious garden, white and sandy beachfront, solarium and access to the rooftop terrace, which offers a breathtaking panoramic views of the sparkling Caribbean to the east, and the lush Mayan jungle to the west.
Outside, the white sand is cut by palm trees that are maintained by on-site caretakers. The poolside patio, and ocean-facing swimming pool promises hours of shaded relaxation after a day of tropical activities like snorkeling or windsurfing. For those who prefer land-based activities, a world-class golf course is right across the street. The condo is 1.5miles from the quaint downtown area, which is full of shops and restaurants. Best of all, this sleepy community is quickly accessible via Cancun International Airport, which is just an hour’s drive away.
Inside, the open layout--boasting new hurricane resistant seaward windows and sliding glass doors, and an expansive terrace overlooking the Caribbean--blends luxury details with stunning Caribbean surroundings. The modern wood furniture, living room with flat-screen TV and air conditioning are sure to delight you and your guests. The kitchen is fully equipped for meal preparation with premium stainless steel appliances and granite countertops. Finally, the bedrooms and bathrooms were recently updated with new tiles. There is a king-size bed in the master bedroom and two single beds in the guest room.
This outstanding ocean-view apartment won’t be on the market long. Contact on of our friendly agents for more details today


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Chiles (Capsicum spp.) have been cultivated in Mexico for centuries and are a vital ingredient in Mexico’s traditional cuisine, recently recognized by UNESCO as an “Intangible Cultural Heritage of Humanity.” Spicy chiles also have numerous medicinal uses. Graphical representations of chiles have even been used as a national symbol.
Chiles are native to Mexico and central America. Evidence for chiles in the diet of indigenous groups in Puebla’s Tehuacán Valley dates back at least as far as 6500BC; by 4100BC, the plant was already domesticated.
There are more than 100 varieties of chiles, grouped into 22 groups of green chiles and 12 of dried chiles. Green chiles by far the most important in volume and value of production and trade. Mexico remains the world’s leading exporter of green chiles and is the sixth largest exporter of dried chiles. The world’s leading producer of green chiles, almost entirely for domestic consumption, is China.
The ideal conditions for cultivating chiles are:
- growing season temperatures of 18-27̊C daytime and 15-18̊C during the night.
- rainfall of 600-1250 mm/yr, with no marked dry season.
- light, humus-rich soils with adequate moisture retention and drainage
- soils with a pH between 5.5 (slighty acidic) and 7.0 (neutral)
- growing season of at least 120 days
Crop yields can be adversely affected by:
- plant diseases,
- climatic hazards, such as hailstorms, rainstorms (fields need efficient drainage systems) and frost, the risk of which is countered by burning waste to create smoke to maintain temperatures above freezing
Time frame for cultivation
- on commercial chile farms, seeds are usually sown in enclosed, heated, nursery beds, since temperatures of 20-24̊C are considered ideal for germination
- seedlings are transplanted after 25-35 days when they are about 10-20cm in height – optimum yields require 20,000-25,000 plants per hectare
- the first flowers appear 1-2 months later, by which time the plant is 30-80 cm tall
- the first green chiles ripen about a month after that; chiles can then be picked every week or so for up to 3 months in rain-fed fields, or sometimes over an even longer period in irrigated fields.
In ideal circumstances, harvesting is possible all year. There are two major, overlapping harvest periods each year, with a fall-winter crop from December-August, and a spring-summer crop from June to March.
Yields vary greatly, reflecting different qualities of soil, water supply and technification employed. The average yield across Mexico is 14-15 metric tons/hectare. Yields in Zacatecas (which has a larger cultivated area of chiles than any other state in Mexico) are only 7 tons/ha, while yields in Sinaloa reach as high as 40 tons/ha.
Types of chile grown in Mexico
The most commonly grown chiles in Mexico are jalapeño, serrano, habanero, poblano and morrón (bell pepper). Seven varieties of green chiles represented 90% of Mexico’s total production of chiles in 2008, and 60% of its total revenue from chiles. Chiles vary in color, heat, size and texture:
Even for a single species, the “heat” of its chiles varies from one plant to the next, as well as from one soil or location to another. The heat of chiles is measured in Scoville units. The hottest chile is generally thought to be the habanero (100,000-445,000 Scoville units). By comparison, the jalapeño is 2,500-5,000 units and the morrón chile (bell pepper) registers 0 Scoville units.
- The cultivation of chiles in Mexico (the specifics of commercial chile production in Mexico)
Main source for statistics (pdf file): Un panorama del cultivo del chile, SAGARPA: Servicio de Información Agroalimentaria y Pesquera, June 2010. [accessed January 28, 2011]
Agriculture in Mexico is analyzed in chapter 15 of Geo-Mexico: the geography and dynamics of modern Mexico. Ask your library to buy a copy of this handy reference guide to all aspects of Mexico’s geography today! Better yet, order your own copy…


text:
This is a neurological issue that is one of the features of AD/HD, but could also be a feature of any number of other neurological challenges. A child who has pdd-nos, a child with OCD, cerebral palsy, and a number of other conditions may have eyes that are unstable. In addition to the pons and midbrain level traumas or developmental gaps that might produce visual instability, there can also be a viral component. I am working with a family who is also working with Dr. Klinghardt and whenever the retro-viral load in the system goes down through treatment the tics, including visual-motor small and rapid movements, called saccades, are significantly reduced or disappear.
As for the interesting differences between children,we want to remember that ‘each brain is a universe unto itself”. You can’t see dysfunction in a child and predict the neurodevelopmental challenges that you will see in testing. And you cannot assume from functional neurodevelopmental testing what the diagnosis would be unless you have seen the child him/her self.


text:
23 - 24 August 2016
Flaminio Torri (Bologna 1620-1661 Modena)
oil on canvas
28 3/4 x 22 1/2 in. (73 x 57.2 cm.)
Anonymous sale; Sotheby's, New York, 14 January 1994, lot 189.
Anonymous sale; New Orleans Auction Galleries, New Orleans, 10 October 2009, lot 608 ($26,400).
Acquired at the above sale by the present owner.
Contact Client Service
New York +1 212 636 2000
London +44 (0)20 7839 9060
Asia +852 2760 1766
Please note the correct property title for this lot is Property From the Estate of Richard D. Bass.
PROPERTY FROM THE ESTATE OF RICHARD D. BASS
Two leading industry insiders give their tips for achieving museum-quality illumination at home
From plant-themed porcelain to baroque birds and lemons — 5 specialists reveal what they’d buy from our Living with Art sale
Pierre Frey discusses his grandfather’s Parisian fabric house, his design philosophy and his picks from our Collector sale in New York
The designer and co-founder of Maximalist Studios creates room sets incorporating pieces from our December Interiors sale
The New York-based designers are curating our August Interiors sale, and have been inspired by the lots on offer to create two capsule collections
Award-winning designers, a museum director, and Christie’s own specialists and art handlers share their expert tips


text:
Senior defenseman Nathan Kellis is taking his talents to Birmingham. In addition to playing for Oviedo High School, Nathan played club lacrosse for the Florida Fightin’ Possums.
Birmingham Southern is an NCAA Dlll program in Birmingham, AL. The Panthers play in the SCAC. The 2012 season will be the third season in the Panthers program. The Panthers had a fantastic 6-1 conference record in 2011 finishing second in the SCAC to Colorado College.
Nathan carries an impressive 3.03 GPA and intends to major in Secondary Education with hopes of coaching high school lacrosse/ becoming an athletic director.
“I’d like to thank my coaches for everything they’ve done over the years to improve my skills and abilities, my teammates for playing aside of me, and my parents for supporting me through all my decisions and dreams.”
Welcome to the newest place to find all of the latest Florida lacrosse news, info, and people. Florida Lacrosse News is dedicated to providing a source of information for all things lacrosse in the Great State of Florida.

domain: sports


On Twitter + Facebook + Instagram
Amanpour producers on Twitter
Check showtimes to see when Amanpour is on CNN where you are. Or watch online.
In this web extra, CNN's Christiane Amanpour speaks with Angela Kane, U.N. High Representative for Disarmament Affairs, about alleged Syrian evidence that the opposition used chemical weapons, asl well as about the difficulties presented by gathering evidence in a war zone.
Amanpour's full interview with Kane can be seen here.
Monday – Friday:
1900 & 2200 London
2000 & 2300 CET
2:00pm & 5:00pm ET
Asia, Tuesday – Saturday:


text:
“Just keep it up” by Dee Clark was first released in the UK on London American 45-HL 8915 and was re-released in the UK on Sue ILP 934 Soul 66. There is more information about Dee Clark here.
Billboard R&B No. 9 and pop No. 18, 1959.
UK Pop No. 26, 1959.
Updated 6 October 2016


text:
Hollywood Super-Hero Movie “Iron Man 3”
Iron Man 3 is an upcoming hollywood super-hero film featuring the Marvel Comics character Iron Man. This film is directed by Shane Black. The film is produced by Marvel Studios and distributed by Walt Disney Studios Motion Pictures. This film is an epilogue to Iron Man and Iron Man 2. Iron Man 3 is expected to be released on 18th April 2013 at United Kingdom and on 3rd May at United States of America. The visual effects were executed by the team work of the companies of Scanline VFX, Digital Domain and Weta Digital. The characters in this film are dramatized by Robert Downey Jr. as the title character, Gwyneth Paltrow as 'Pepper Potts', Don Cheadle as 'James Rhodes' and Favreau as 'Happy Hogans'. The other casting crew of this film are Guy Pearce, Rebeca Hall, Stephanie Szostak, James Badge Dale and Ben Kingsley. The shooting if this film was carried out in China, Los Angeles and Florida with most of the scenes shot in North Carolina.


MANILA, May 1 — President Aquino tasks De Lima to fast tract proof of Mary Jane Veloso’s innocence. Yes, President Benigno S. Aquino III has ordered Justice Secretary Leila de Lima to fast-track the legal process that may prove overseas worker Mary Jane Veloso is innocent of drug trafficking and bring her recruiters to the bars of justice.
“I will be tasking the Secretary of Justice in particular to expedite the whole process of really ferreting out all of the facts so that we can bring to the bars of justice all concerned and perhaps facilitate the capture of others, especially on the drug front who brought her to this predicament,” he said in a media interview in Bacolod City.
President Aquino expects the legal processes to be completed in about two months. “We’re in the preliminary investigation stage… My understanding is the SOJ (Secretary of Justice) will be talking to their attorney general to discuss all our procedures,” he said. The president added there was no discussion yet on the case of Veloso, but “they saw the value of being able to elicit her testimony to serve the ends of justice.”
The Indonesian government led by President Joko Widodo gave reprieve to Veloso who was facing death in Indonesia for drug smuggling. She was set to be executed by firing squad on Tuesday.


text:
NEW YORK, NY – JANUARY 29: Daniel Beltrami, 10, of New Jersey completes an obstacle course presented by NFL Play 60 on Super Bowl Boulevard on January 29, 2014 in New York, New York. In preparation for the Super Bowl sections of Times Square and Broadway host various games, sponsor booths, and TV broadcasts.(Photo by Maddie Meyer/Getty Images)
NBA 18m ago
Shumpert is taking a break from the flat top.
MLB 34m ago
The 25-year-old slugger isn’t the biggest story in his own infield, but owns a .957 OPS.
Olympics 36m ago
The Olympic gymnast opened up about body acceptance.
Soccer 1hr ago
According to the YouTube video’s description, this is what happened: Towards the end of a close 3-3 Romanian Cup game (…)
NBA 1hr ago
Who’s up for a scavenger hunt?
Hockey 2hr ago
For those who have always secretly hoped that the Anaheim Ducks players and coaches would eventually become the characters from the (…)
NHL 2hr ago
After 16 seasons in the NHL, 40-year-old Martin St. Louis has decided to hang up his skates. St. Louis went un-drafted out of the (…)


Na Muthukumar passed away in Chennai at the age of 41 years. He was suffering from jaundice for the past few days. He won two national awards for the songs Ananda Yazhai Meetukiral in Thanga Meengal and Azhage Azhage in Saivam.
He has written songs for more than 1000 films. In 2012 alone, he has written songs for about 102 films.
Source: The Hindu


text:
Does T-Mobile (NASDAQ: TMUS) make money?
Many investors will wonder if T-Mobile (NASDAQ: TMUS) is making money because of its growth.
The number of T-Mobile US subscribers grew from 66.71 million in the first quarter of 2020 to 103.44 million in first quarter of 2021, Statista estimates. Thus, I calculate T-Mobile’s American subscriber base grew by 36.73 million customers in a year.
Conversely, T-Mobile’s US subscriber base fell from 86.05 million in fourth quarter of 2019 to 66.71 million in the first quarter of 2020. Statista attributes that fall to a change in T-Mobile’s subscriber policies. Notably, T-Mobile’s US subscriber base grew from 86.05 million in fourth quarter 2019 to 102.06 million in fourth quarter 2020.
Is T-Mobile a Tremendous Value Investment?
Thus, T-Mobile (TMUS) is capable of tremendous growth. Moreover, most of those subscribers pay T-Mobile $60 to $85 a month for their phones.
Since a phone is vital to life in modern America. Most of those people will pay that $60 to $85 even if they have to scrimp on the grocery bill or delay the rent.
Consequently, T-Mobile could be a tremendous value investment because it could generate enormous amounts of float. The float is a constant stream of subscription or premium revenue a company can tap for any purpose.
For example, T-Mobile can use the subscription float to expand its 5G network or pay of debt. In addition, T-Mobile can borrow against the float to pay for acquisitions.
How Much Cash Does T-Mobile Generate?
Fortunately, we can put this theory to the test by examining T-Mobile’s cash flow. I think T-Mobile’s cash flow numbers prove this theory.
For example, T-Mobile (NASDAQ: TMUS) reported a quarterly operating cash flow of $5.03 billion on 31 March 2021. The quarterly operating cash flow grew from $2.342 billion on 31 March 2020.
In addition, T-Mobile reported quarterly ending cash flow of $6.759 billion on 31 March 2021. The quarterly ending cash flow grew from $1.112 billion on 31 March 2020.
How Much Debt does T-Mobile Accumulate?
On the other hand, T-Mobile (TMUS) got a lot of that cash by borrowing. Notably T-Mobile reported quarterly financing cash flows of $2.505 billion on 31 March 2021 and $3.227 billion on 31 December 2020.
The quarterly financing cash flow fell from $14.551 billion on 31 June 2020. T-Mobile also pays off enormous amounts of debt. It reported a quarterly financing cash flow of -$7.289 billion on 30 September 2020.
Dramatically, T-Mobile’s Total Debt grew from $42.021 billion on 31 March 2021 to $110.942 billion on 31 March 2021. Thus, they built T-Mobile’s massive 5G network with debt.
How Much Money Does T-Mobile (TMUS) Make?
T-Mobile (TMUS) makes enormous amounts of money from that network. For instance, T-Mobile reported quarterly revenues of $19.759 billion on 31 March 2021. The quarterly revenues grew from $11.113 billion on 31 March 2020.
Similarly, T-Mobile reported a quarterly gross profit of $7.097 billion on 31 March 2021. The quarterly gross profit grew from $5.227 billion on $31 March 2020.
However, T-Mobile reported a quarterly operating income of just $2.139 billion on 31 March 2021. The quarterly operating income grew from $1.539 billion on 31 March 2020.
Consequently, T-Mobile had $6.677 billion in cash and short-term investments on 31 March 2021. The cash and short-term investments rose from $1.112 billion on 31 March 2020.
T-Mobile is Capable of Enormous Growth
T-Mobile (NASDAQ: TMUS) experienced enormous growth during the pandemic.
In particular, the Total Assets grew from $87.226 billion on 31 March 2020 to $203.332 billion on 31 March 2021. Thus, T-Mobile’s moneymaking capacity grew dramatically during the COVID-19 pandemic.
Notably, Stockrow estimates that T-Mobile’s revenues grew by 79.8% in the quarter ending on 31 March 2021. In contrast, T-Mobile’s revenue grew by 0.3% in the quarter that ended on 31 March 2020.
Mr. Market has noticed that growth. T-Mobile’s share price grew from $104.15 on 30 June 2020 to $144.88 on 31 June 2021. Plus, T-Mobile had a $180.6 billion Market Cap on 30 June 2021. Thus, I consider T-Mobile an attractive growth stock with a decent margin of safety.
What Value Does T-Mobile Have?
I think T-Mobile’s value comes from its massive subscriber base and its enormous coverage map.
The coverage map at T-Mobile’s website claims the company’s 4G and 5G network covers most of the mainland United States. For example, T-Mobile claims to cover all of North Dakota and Nebraska, almost all of Minnesota and Michigan, and most of my home state of Colorado.
However, the map shows there is no T-Mobile coverage in many mountainous areas including much of Idaho and Nevada. In addition, T-Mobile service is unavailable in large areas of California and Northern Mexico.
T-Mobile’s embrace of 5G is impressive
T-Mobile’s embrace of 5G is impressive. The company claims that all of its plans include 5G. To elaborate, 5G is fifth generation wireless network technology that can more data. T-Mobile claims 5-G is faster and more flexible than 4G LTE. Unfortunately, T-Mobile’s website does not say how much of North America its 5G Network covers.
I think the growth justifies the $146.29 Mr. Market paid for T-Mobile US (TMUS) on 2 July 2021. However, I cannot tell if the growth is sustainable.
If you are seeking a growth stock that could become a strong value investment, T-Mobile is worth a look.


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