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The participants in the 'Global Youth Interfaith & Intercultural Forum, Qatar 2023,' which kicked off Saturday in Doha, stressed the growing importance of involving young people in promoting the values of dialogue between different cultures, especially between religions, as this approach considered as one of the effective mechanisms for building bridges of communication between societies, knowing the other, and establishing a culture of mutual respect.
The participants believed that the forum and other international activities and events devoted to interaction and increasing communication between religions are an important incentive to qualify a new generation of young people who are imbued with a culture of dialogue and peaceful coexistence with others, especially in light of the many challenges the world is witnessing that threaten peace and coexistence and the widespread violent conflicts.
They pointed out that the forum, which reviews over four days, will provide a space that allows in a more specific way to enhance the involvement of this segment and benefiting from its experiences and expertise, and exchanging ideas and initiatives, which will have a resonance and lead to a better understanding of the other and the development of solutions and perceptions of several challenges facing contemporary societies, including the youth themselves.
Also, the participants stressed the impact of the forum in highlighting the concerns of the new generation and making the desired impact among this segment, especially in terms of acquaintance and acceptance of others, which necessarily leads to the dedication of a culture of dialogue and peaceful coexistence among followers of religions and civilizations to lay the foundations for world peace and to combat discrimination based on religion or belief.
World Cup success
In a statement to Qatar News Agency (QNA), the CEO of the Stirling Foundation in the US, Edward Rowe, said that the forum brings together an elite group of global youth active in the field of dialogue, especially after Qatar organised the best World Cup edition.
He underscored that achieving the principle of integrity in this tournament was one of the factors that contributed to this success and building on common universal values, praising the important role that Qatar has played and is still playing in interfaith dialogue as it "represents the best example in many ways."
Rowe congratulated Qatar and its people for the World Cup success, saying that they have shown integrity in this tournament represented in their ability to adhere to their values, and religious and moral system despite the pressures exerted to force them to change that.
He added that the Qataris faced those challenges and succeeded in welcoming the world with appreciation and respect for cultural and religious diversity while preserving their convictions, identity, culture, and value system. Rowe considered that humanity's current changing world requires arriving at an inner peace that stems from the adherence to one's convictions, yet without the exclusion of others, instead accepting them, interacting with them, respecting differences, and being honest with oneself and with others, adding that given the current moment, it is important to unite peoples of different races and religions in achieving important goals that would aid humanity in facing all of its challenges and tragedies.
He said the Stirling Foundation supports many different programs around the world, including those focused on youth and interfaith dialogue to bring together young influencers into a single venue that is known for its commitment to interfaith dialogue, for them to then hopefully be able to return back to their respective communities and to cause a positive impact.
For her part, Member of the Board of Trustees at Common Word Among the Youth (ACWAY) Lola Matmusaeva said that the members of the youth who are participating in the forum's current edition were chosen from among more than 1,300 applicants and were selected due to their clear vision towards peace, dialogue enrichment, and non-discrimination in their societies.
She called on her young colleagues to maintain their vitality and be active throughout the forum's sessions, as well as to participate actively in the forum to make maximum use of its sessions, paving the way for building long-term relationships and sharing their experiences and success stories in overcoming global challenges and complex issues that must be dealt with.
Matmusaeva said that ACWAY, a UK-based co-organizer of the forum, is a global youth movement that brings together young people of any array of backgrounds to increase their understanding of different cultures and religions, and to promote peace and coexistence globally. Global Youth Interfaith and Intercultural Forum — Qatar 2023 is held under the theme 'Youth and Peacebuilding: Interfaith Dialogue from Theory to Practice' and is organised by the Doha International Center for Interfaith Dialogue, together with ACWAY.
A group of young people active in human rights work and voluntary civil service is participating in the forum, with more than 60 young men and women from 42 countries, in addition to 20 male and female participants from Qatar. The forum's agenda includes a number of axes, most notably peace through interfaith understanding and communication. The other axes are from diversity to pluralism, Islam's approach to getting to know the other, understanding religions' place in the lives of the youth in light of contemporary changes, as well as youth work, co-operation, and global citizenship, in addition to the exchange of ideas, experiences, and initiatives to enhance interfaith and intercultural understanding.
Qatari Executive TV Presenter Mohamed Saadoun al-Kuwari emphasised during a presentation in the forum's opening session, the importance of sport in enhancing the value of dialogue, with sports being an occasion for communication and convergence rather than just being a competition for victory and belonging. Additionally, the forum's opening session witnessed interventions by participants from international youth organisations, dealing with the global youth forum's great significance, especially as it comes at a time when young people are suffering from several challenges, in addition to contemporary societies' crises that require the help of young people's energetic role in facing these challenges and crises, in the pursuit of peace and stability, which necessitates religious and cultural diversity and pluralism globally.
Participants at the forum
Participants at the forum
Participants at the forum


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- Want Now: One recently released or already published title I’m lusting after.
- Want Soon: One upcoming title I’m looking forward to, based on things I’ve heard, the cover, and the description.
- Want Someday: One upcoming title I’ve heard about that sounds like it could be interested but is so far off into the future it doesn’t even have a cover yet.
Matthew has loved Ariel from the moment he found her in the tunnels, her bee’s wings falling away. They live in Safe, an underground refuge for those fleeing the city Above—like Whisper, who speaks to ghosts, and Jack Flash, who can shoot lightning from his fingers.
But one terrifying night, an old enemy invades Safe with an army of shadows, and only Matthew, Ariel, and a few friends escape Above. As Matthew unravels the mystery of Safe’s history and the shadows’ attack, he realizes he must find a way to remake his home—not just for himself, but for Ariel, who needs him more than ever before. — Goodreads
In a city of daimons, rigid class lines separate the powerful from the power-hungry. And at the heart of The City is the Carnival of Souls, where both murder and pleasure are offered up for sale. Once in a generation, the carnival hosts a deadly competition that allows every daimon a chance to join the ruling elite. Without the competition, Aya and Kaleb would both face bleak futures–if for different reasons. For each of them, fighting to the death is the only way to try to live.
All Mallory knows of The City is that her father–and every other witch there–fled it for a life in exile in the human world. Instead of a typical teenage life full of friends and maybe even a little romance, Mallory scans quiet streets for threats, hides herself away, and trains to be lethal. She knows it’s only a matter of time until a daimon finds her and her father, so she readies herself for the inevitable. While Mallory possesses little knowledge of The City, every inhabitant of The City knows of her. There are plans for Mallory, and soon she, too, will be drawn into the decadence and danger that is the Carnival of Souls.
From Melissa Marr, bestselling author of the Wicked Lovely series and “Graveminder,” comes a brand-new tale of lush secrets, dark love, and the struggle to forge one’s own destiny.
Want Some Day:
No cover yet for Loki’s Wolves!
From Publisher’s Weekly –
The Blackwell Pages will tell the story of two 12-year-old boys and one girl, all distant descendants of the Norse gods, who must journey to prevent the impending Ragnarok (the apocalypse). The first book, Loki’s Wolves, is slated for publication in Spring of 2013.
[…] Now: One recently released or already published title I’m lusting […]

domain: literature


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Quite apart from Welsh-born writers, the list of authors who have Welsh connections is both long and distinguished.
They range from Harriet Beecher Stowe, the doyen of emancipation and author of Uncle Tom's Cabin to the American humorist Ogden Nash and adventure writer Jack London who gave us The Call of the Wild.
The writers mentioned above may have had only tenuous connections with Wales but some - although clearly not Welsh - have far stronger connections, such AJ Cronin, Eric Linklater and Kingsley Amis.
AJ Cronin is best remembered, these days, as the man whose novella The Country Doctor was later adapted for television and became Dr Finley's Casebook.
However, many people consider his true masterpiece to be The Citadel, 1937 - the story of a Welsh doctor who begins his career in a south Wales mining village before moving to London where he climbs up the social and professional ladder to success.
A scene from Dr Finley's Casebook in 1966 starring Bill Simpson.
Cronin was born in Dunbartonshire and qualified as a doctor before starting to practice in Tredegar.
It was while he was working at the Tredegar Cottage Hospital that he met Aneurin Bevan and some people believe that the ideas expressed in the book formed the foundations for the formation of the National Health Service in 1948.
While working in Wales, AJ Cronin experienced a mining disaster where 38 men were killed and a further 20 rescued after spending eight days trapped underground.
Cronin used the experience in his later work after retiring from his post as Medical Inspector of Mines for the UK.
He went on to write many other books, notably The Stars Look Down - set in a mining community in north east England.
Eric Linklater was born on 8 March 1899 in the Welsh port of Penarth. For many years it was believed that the writer whose best-known books include Juan in America and Private Angelo was born in the Orkney Islands.
Eric Linklater has a toast with TV producer Julia Smith in 1963.
His family was Scottish after all and Linklater's own avowed love of the Orkneys helped perpetuate the myth.
It was only when the third volume of his autobiography, Fanfare for a Tin Hat was published in 1970 that Linklater revealed that he was actually born in Penarth.
Linklater's father was a master mariner operating out of Penarth which at the time of his son’s birth was one of the largest coal-exporting docks in the world.
Eric Linklater was initially educated at Cardiff Intermediate School before his family moved back to Scotland.
Once there he began to train as a doctor but soon switched to journalism and became the Assistant Editor of The Times of India in Bombay and so his career as a writer began.
It was a career that saw him produce 23 novels, several collections of short stories and more than 20 other books. And to think it all began in Penarth.
Kingsley Amis, born in April 1922, arrived in Wales in 1949 when he was appointed as a lecturer at University College, Swansea. He remained in Swansea for 12 years, leaving to take up a post at Cambridge in 1961.
Amis has since gone on record as someone who did not particularly like the Welsh - he certainly disliked Dylan Thomas who came to read at the University while he was there.
Kingsley Amis, 1964.
He made his name with the campus novel Lucky Jim but used Wales as the location for two other books.
That Uncertain Feeling was later made into a film starring Peter Sellers and was set in Swansea.
It concerned the adventures of a hapless provincial librarian who also doubled as a theatre critic, a man who wrote a glowing review about a play, even though the theatre had burned down during the performance.
Then, towards the end of his life, Amis wrote The Old Devils which won him the Booker Prize in 1986.
This latter book has several Dylan-esque characters and centred on the theme of a renowned writer and TV personality coming home to Wales. Kingsley Amis died in 1995.
The influence of Wales has clearly been significant for several writers who have encountered and embraced the Welsh culture at different stages of their creative lives.


Is rock and roll dead? Not according to The Howling Tongues.
When I first heard “Vivian,” the Atlanta quintet’s ear-blistering anthemic jam, I’d just moved to Atlanta. I grew up in a town so small it barely warrants mentioning. It’s a bump in the road in the southeastern corner of Georgia where The Beatles’ records had been publicly burned in the ‘60s and rock ’n roll was still a four letter word half a century later.
Everything was foreign — exhilarating, thrilling, and at times like a scene from an action movie (hello, I-85 explosion, I’m looking at you!).
That is, until I heard “Vivian.”
My first thought was, “How could I have possibly missed this?”
It was a tour de force of scathing guitar riffs, a rumbling bass line weaving around a shameless groove, and screaming keys. Then there were the raspy, soulful vocals launching a rocket to the moon and bewailing the space vampire Vivian’s unquenchable thirst while boldly refusing to be a part of her new world order. To be honest, I imagined it was some forgotten lovechild of Bowie and The Who, left to the mercies of Jack White’s neurotic irreverence and the Stooges’ primal ferocity, amalgamating in what the band describes as, “a boogie-inducing rock ’n roll hurricane.”
A Frankensteined garage-rock creation of the most bombastic bands of the 70s heyday, The Howling Tongues’ 2016 release Boo Hiss was the result of the Atlanta natives taking full creative control.
Their self-titled LP, released three years prior, gave fans a taste of their reckless, no-holds-barred dedication to the resurrection of rock ’n roll, but it wasn’t until lead singer Davey Rockett, guitarist Nick Magliochetti, bassist Brandon Witcher, drummer Tylor James, and the “mad scientist” organist and pianist Thomas Wainwright hunkered down in their studio to write and demo a grand total of thirty songs that the raucous energy of their live performances were captured on tape.
For the first time in a long time, no producer was guiding the band’s sound or making decisions for them.
In some ways, it was reminiscent of the bands’ conception during a week-long ice storm in 2011, when the childhood friends and lifelong musicians were trapped in the basement together with only a pile of rock records at their disposal. Left to their imaginations, the recording process was electric, at times bordering on ingenious insanity reminiscent of John Lennon during the Abbey Road days (though, as far as I know, none of The Howling Tongues asked to be hung upside down from the ceiling and swung around a microphone to create a modulating vocal effect).
The live room became a laboratory where procedure went up in smoke: they experimented with tones, tunings, and sounds, ran vocals through a guitar amp and pedals, and worked and reworked parts until they and engineer T.J. Elias (Blackberry Smoke, Walk the Moon, Third Day) reached what I’ve found so often eludes musicians: satisfaction.
The result? A gritty, power-packed nine-song offering to the gods of rock ’n roll.
From the first overdriven rift of “Raw Power in a Red Dress,” the “brazen bastard stepchild of The Stooges’ “Raw Power” and The Hollies’ “Long Cool Woman (In A Black Dress),” to the final note of “S.O.S.,” a compulsory hip-shaker that I envisioned losing my voice screaming along to in any stadium in the world. From top to bottom, Boo Hiss offered children of the seventies a mixed drink of nostalgia and excitement while exposing the lurid glamour of rock and roll to a new generation of music lovers.
In the almost two years following the release, this band of brothers has done anything but slow down. Remember that cover of Creedence Clearwater Revival’s “Around the Bend” in the Wrangler commercial, the one that left you asking an empty room, “who is that?” Ladies and gentlemen, The Howling Tongues.
Following a national tour in early 2017 with Austin, Texas’s enigmatic indie royalty Leopold and His Fiction, the Tongues made a triumphant return to New York’s storied rock club, Arlene’s Grocery, leaving crowds dazed and confused by their signature one-two-punch of a rock show at Fort Collins, Colorado’s Aggie Theatre. In April 2018, years of late nights, long drives, and dogged dedication to the music paid off when they were tapped to play their biggest show to date: opening for 2018 Rock and Roll Hall of Fame Inductee Bon Jovi at Atlanta’s Philips Arena in front of 21,000 people.
But if you ask them — or anyone in the crowd at one of their hometown shows what the most exciting aspect of the group is, the answer might surprise you. It’s not the commercial placements, the arena shows and festivals in front of thousands of fans, or their highly anticipated 2018 release, set for late summer. It’s the heart behind the music, the brotherhood and camaraderie on and off stage, and the realization that yes, it’s still possible for five people to come together with one goal: to make the best rock record in the world.
Call it high-minded, call it cocky — hell, if you’re a real cynic, call it impossible. The Howling Tongues just call it rock ’n roll.
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With a total diagonal distance of the Sandia Peak Tram is the longest aerial tram in the world. The tramway ascends the steep western side of the highest portion of the Sandia Mountains, passing close to dramatic cliffs and pinnacles, from a base elevation of to a top elevation of . A trip up the mountain takes fifteen minutes to ascend , and the normal operating speed of the tram is 12 miles per hour (19 kilometers per hour). Approximately four "flights" leave every hour from the base and top departure stations. The view from the tram includes all of Albuquerque and roughly 11,000 square miles (28,000 square kilometers) of the New Mexico countryside.
The tramway has just two support towers. The first tower, which is tall, is situated at an elevation of above sea level and built as an inclined tower with an inclination angle of 18 degrees. The second, just tall, is situated at the end of a major spur of the mountains at an elevation of and was built by helicopter aid.
The longest span is between the second tower and the top terminal. This span is the third longest clear tramway span in the world, at a length of . Mid-span, the cables are above the mountainside. This span passes over Domingo Baca Canyon, part of which is referred to as TWA Canyon. This is the site of the crash of TWA Flight 260 on February 19, 1955, in which the lives of all 16 passengers and crew were lost. While much of the wreckage was removed during construction of the tramway, some still remains on the canyon floor and may be visible to riders of the tram.
At the top of Sandia Peak there are many year-round recreational options. The High Finance Restaurant is directly adjacent to the top tram terminal and offers scenic views. Many Forest Service trails offer recreational hiking, backpacking and nature hikes to visitors. Additionally, the tram terminal is located at the top of Sandia Peak Ski Area which is on the opposite side of the mountain from the tramway and the city. Skiing is available in the wintertime, and during the summer over 26 miles (42 kilometres) of mountain biking trails are available.


Data assimilation of remote sensed sea surface temperature on the Atlantic basin and a nested window via a hydrodynamic model
A 4D-VAR data assimilation method involving an ocean primitive equation model and its adjoint, using satellite sea surface temperature observations has been successfully implemented and applied in an open boundary upwelling region and North Atlantic Ocean. The data assimilation procedure is applied for two different real applications: firstly on a nested window along the coast of west Mauritania in the vicinity of Cap-Blanc and secondly on the whole North Atlantic Ocean basin. In both cases the assimilated data are observations of sea surface temperature. High data quality has prompted the necessity of developing more realistic and reliable algorithms to detect sea surface temperature in an improved way. The results obtained showed good agreement with the surface observations and with the physics characteristic for the studied areas.
Bibliographic Reference: Paper presented: Third International Conference Hydroinformatics 98, Copenhagen (DK), August 24-26, 1998
Availability: Available from (1) as Paper EN 41572 ORA
Record Number: 199810971 / Last updated on: 1998-09-01
Original language: en
Available languages: en


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The first weeks of writing workshop are filled with establishing daily routines, getting to know our students as writers, setting up writer’s notebooks and supporting students in generating topics that they might want to write about. In Anne Elliott and Mary Lynch’s newest professional resource, Cultivating Writers, they share a neat activity to show student writers “…that their neighborhood, community, city, country, and world are all sources of writing potential.” The activity is called Destination Known/Unknown.
Using the template shown below, follow/model the following:
- Show students that the center represents the location closest to where they live (i.e neighborhood) and subsequent circles moving outward represent increasing distances from their home: community, city, country, world.
- In the innermost circle, model for students how to generate places in their neighborhood they enjoy going to and are linked to a memory; e.g, local park, hockey arena, skate park, local diner, variety store, etc.
- Have students generate ideas for other destinations. Whether students have first-hand knowledge and experience traveling to a particular destination or need time to investigate and research a dream location, writing about a place opens up a world of endless landscapes and adventures.
- Once students have generated ideas for each circle, have them share some of the locales and tell the class about an adventure they had there, or an adventure they dream of having.
This activity will surely generate some great writing topics, but activities like these do so much more. They connect student’s writing to their world outside of school, they let us better know our students, and they build an authentic writing community with the sharing of ideas.
This is just one activity from this amazing resource, and we recommend Cultivating Writers to every teacher of writing who believes as these authors do that: “We have the responsibility, the obligation, and the duty to create an environment in which kids flourish into writers who have the skill and the will.”
Here is the template:


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Monday Mar 17 2008
Traditional fare brings St. Patrick's Day home
By: Jenna Nielsen, Journal Staff Writer
Stores stocked with corned beef, soda bread, cabbage
There's no need to leave home to celebrate St. Patrick's Day this year. Local grocery stores are making it easy to commemorate the day without stepping out of the house. We have everything, said Tim Lalley, assistant store manager at Save Mart in Auburn. Of course we have corned beef, cabbage, red potatoes, carrots, Irish soda bread and Irish liquors and beers. Lalley said the store also carries a selection of St. Patrick's Day themed cookies and cakes. Nicole Townsend, spokeswoman for Raley's/Bel-Air, said the Auburn stores are also stocked up on the St. Patrick's Day staples. We have great cuts of corned beef to start the traditional St. Patrick's Day meal, Townsend said. The corned beef comes with a spice packet so you can make it at home. Corned beef also comes with one free cabbage to round out your meal. And if you don't have time to make the beef yourself, Raley's sells it cooked and ready in the deli. Raley's also has several recipes on its Web site, raleys.com. Customers can find 20 Irish-themed dishes including apple and brown sugar corned beef, shepherd's pie, Irish soda bread and beef and Guinness stew. St. Patrick's Day is kind of like Thanksgiving, said Lowell Baker manager of Bel-Air in Auburn. At Thanksgiving, everybody buys turkey, and St. Patrick's Day is the only day that people really buy corned beef. Baker said the store has already sold a lot of corned beef, and can't keep the shelves stocked enough. Sales are through the roof, he said. People just feel festive whether they're Irish or not. The day gives people a day to celebrate. Like Save Mart, Raley's and Bel-Air stores also have Irish soda bread and bakery items including shamrock cookies and cupcakes with green sprinkles on them. Grass Valley residents Tom and Antoinette Sassman shopped for corned beef at Bel-Air Saturday afternoon. We keep up with our traditions from when we lived in New Jersey, Tom Sassman said. Sassman said his grandfather was Irish. And besides eating corned beef, the couple also prepares cabbage with carrots and potatoes. No matter what you decide to cook, Townsend said celebrating at home is simple this year. Our recipes are right on (the) home page of our Web site, Townsend said. And everything is ready in our store. We want to make it easy for people to celebrate at home. The Journal's Philip Wood contributed to this report. The Journal's Jenna Nielsen can be reached at email@example.com.

domain: news


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Firstly it’s so good to see Sunny Deol back on big screen. I know last time he was seen in 2015 but hardy anyone saw him in I Love NY. This time he is back with a bang. That dhai kilo ka haath, his anger, his dialogues are something to look for in Ghayal Once Again.
Ghayal Once Again starts with some scenes from Ghayal taking you down the memory lane. So good to see young Sunny Deol, nothing much has changed though. This installment; for namesake is just continuation but Ajay Mehra do retain his intolerance for injustice. Very basic story line with good amount of action and chase sequences. That’s where you find your money’s worth.
Surprisingly Ghayal Once Again is very engaging. Initially it’s very unstable but once Sunny Deol makes an entry film takes a different mode. Editing of the film is crisp making it worth watching. Performance wise Sunny Deol is too good anday thats enough. Film has nicely put light on some issues which are lost somewhere. You do start thinking about it while watching the film. Too many VFX heavy shots but that is overshadowed since you are more interested to know about what next.
Film can be easily watched once without any hesitation. I will recommend Ghayal Once Again for Sunny Deol. Must say is a pretty good writer and a director.

domain: entertainment


SC400 wheelchair carrier also works great as a scooter carrier, with lawn and garden equipment such as tillers, snowblowers, mower, or general cargo. Designed to work with cCass III or IV trailer hitches. For securing your wheelchair, scooter or cargo, eleven built in tie-down points have been added along the sides. The hitch cargo carrier’s heavy duty steel construction has a black powder coat finish to give it a sleek look and protect it from rusting. Included with every SC400 cargo carrier is an anti-wobble hitch collar.
Designed for vehicles with a hitch height measured from the ground of 11-14 inches. For taller hitches please see our SC500 that features a longer loading ramp.
|Model||Weight Capacity||Hitch Class||Usable Dimensions||Ramp Dimensions||Max Hitch Height||Center of Pin Hole to Carrier Length|
|Center of Pin Hole to Carrier Length|
|SC400||400 lbs||III or IV||46.5″ long X 28″ wide||42″ long x 27.5″ wide||11″ – 14″||5/8″ Hitch Pin Hole: 14.75″
1/2″ Hitch Pin Hole: 13.75″
|5/8″ Hitch Pin Hole: 7″
1/2″ Hitch Pin Hole: 6″


Blind, 27, has started every Carabao Cup and Champions League game this season but last lined up in a Premier League fixture in August. Ashley Young has cemented himself as United's first choice left-back and Luke Shaw has emerged as his biggest competitor following his bright performances against CSKA Moscow and Bournemouth.
Both Shaw and Blind are contracted to United until the summer and it is understood the club has not yet taken up their option of a one-year extension on their deals.
Blind has been dropped from five of the last seven squads and was derided by United supporters after he gifted Basel a late winner last month. The Netherlands international has been regularly linked with Inter and Spalletti was asked about the club's possible interest.
"Blind? I talk about my players, because the points we win in the next few matches will be done with them," Spalletti told reporters.
"I prefer to talk about my players because it is with them that we will look to be successful."
United signed Blind from Ajax on transfer deadline day in 2014 for £13.8million and he started in their FA Cup and Europa League final triumphs in successive seasons.
Although initially bought as a central midfielder, Blind has primarily played at left-back or left-wing back this season and predominantly played at centre half during Louis van Gaal's second season.
Young, Juan Mata and Sam Johnstone's contracts also expire at the end of the season but United could extend their stays by a year.
Get all the latest Manchester United news first with our new app. Download it here now


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- What state has the most toxic waste dumps?
- How do you clean up toxic waste?
- How can we remove toxic waste?
- What does toxic waste taste like?
- Can warheads damage your tongue?
- Where does toxic waste come from?
- What is a toxic waste site?
- Is Toxic Waste candy banned?
- What is the most toxic state?
- What is the most toxic place on earth?
- What is the most toxic city in America?
- What is the world’s sourest candy?
What state has the most toxic waste dumps?
New Jersey, California, and Pennsylvania have the most sites..
How do you clean up toxic waste?
6 Proven Environmental Cleanup Methods1.) Ground Water Pumping and Treatment: … 2.) Waste Water Treatment: … 3.) Bio-remediation: … 4.) Incineration: … 5.) Thermal Desorption: … 6.) Removal and Disposal:
How can we remove toxic waste?
Most people dispose of hazardous products by throwing them in the trash, pouring them down the drain, burning them, pouring them in a ditch, dumping them on a vacant lot, or burying them in a field.
What does toxic waste taste like?
Toxic waste candy is extreme sour and a true test for your taste buds. At first you’ll experience sour flavor and if you can make it to the middle layer you’ll be rewarded with a sweet taste. Then, just when you thought it was over it’s not. Toxic waste candy has the only double-action sour flavor on the planet.
Can warheads damage your tongue?
Like citric acid, large quantities of malic acid can cause dental erosion and canker sores, thus the product warning: “Eating multiple pieces within a short time period may cause a temporary irritation to sensitive tongues and mouths.”
Where does toxic waste come from?
Hazardous, or toxic, waste is the potentially dangerous byproduct of a wide range of activities, including manufacturing, farming, water treatment systems, construction, automotive garages, laboratories, hospitals, and other industries.
What is a toxic waste site?
Toxic waste is any unwanted material in all forms that can cause harm (e.g. by being inhaled, swallowed, or absorbed through the skin). Many of today’s household products such as televisions, computers and phones contain toxic chemicals that can pollute the air and contaminate soil and water.
Is Toxic Waste candy banned?
In January 2011, the U.S. distributor of the Toxic Waste Nuclear Sludge chew bar variety recalled the product, which was manufactured in Pakistan, due to lead contamination. At the time, the U.S. Food and Drug Administration (FDA) announced that it was unsafe to eat due to this contamination.
What is the most toxic state?
AlaskaSummary of findings: As a state, Alaska produces the most toxins (834 million pounds) Zinc and lead compounds (common products of the mining industry) are the most common toxins.
What is the most toxic place on earth?
Click through to find out where the most-polluted places are and why.Agbogbloshie Dumpsite, Ghana. … Chernobyl, Ukraine. … Citarum River, Indonesia. … Dzerzhinsk, Russia. … Hazaribagh, Bangladesh. … Kabwe, Zambia. … Kalimantan, Indonesia. … Matanza-Riachuelo, Argentina.More items…•
What is the most toxic city in America?
PicherInside the ‘most toxic city in America’ where the earth is poisoned by lead and zinc. The photographer who goes under the pseudonym Seph Lawless is back at it again. This time he’s toured Picher, Oklahoma — the most toxic city in America.
What is the world’s sourest candy?
Toxic Waste may be the sourest candy ever. However, if you can make it past the first 30-45 seconds or so, the sour coating will eventually dissolve, and it’ll actually start to taste like something you want to eat.

domain: chemistry


Carroll County v. Smith, 111 U.S. 556 (1884)
U.S. Supreme CourtCarroll County v. Smith, 111 U.S. 556 (1884)
Carroll County v. Smith
Argued April 27, 1884
Decided May 5, 1884
111 U.S. 556
A recital in a bond issued by a municipal corporation in payment of a subscription to capital stock in a railway compauy, that it is authorized by a statute referred to by title and date does not estop the municipality in a suit on the bond from setting up that the issue was not authorized by vote of two-thirds of the voters of the corporation, as required by the constitution of the state.
A provision in the Constitution of Mississippi that the legislature shall not authorize a county to lend its aid to a corporation unless two-thirds of the qualified voters shall assent thereto at an election to be held therein does not require an assenting vote of two-thirds of the whole number enrolled as qualified to vote, but only two-thirds of those actually voting at the election held for the purpose. Hawkins v. Carroll Co., 50 Miss. 735, disregarded, and St. Joseph's Townskip v. Rogers, 16 Wall. 644, and County of Cass v. Johnston, 95 U. S. 300, followed.
The issuing of a temporary injunction, which was afterwards made permanent, by a state court, restraining municipal officers from issuing municipal bonds does not estop a bona fide holder for value, who was no party to the suit, from maintaining title to such bonds issued after the temporary injunction.
The decision of the highest court of a state construing the constitution of the state is not binding upon this Court as affecting the rights of citizens of other states in litigation here when it is in conflict with previous decisions of this Court and when the rights which it affects here were acquired before it was made.
This was an action at law brought to recover the amount of certain overdue interest coupons upon municipal bonds alleged to be obligations of the plaintiff in error delivered and payable to the Greenville, Columbus and Birmingham Railroad Company or bearer for $1,000 each. Each bond contains the follow recital:
"The above-mentioned sum being a part of a subscription to the capital stock of the Greenville, Columbus and Birmingham Railroad Company, authorized by the following styled acts of the State of Mississippi, viz., an act entitled 'An act to incorporate the Arkansas City and Grenada Railroad Company,' approved March 5, A.D. 1872, and an act entitled 'An act to amend an act entitled an act to incorporate the Arkansas City and Grenada Railroad Company, approved March 5, 1872,' approved March 4, A.D. 1873."
The act first referred to contained the following:
"SEC. 19. Be it further enacted that upon application by the president or other authorized agent of said corporation to the constituted authorities of any county, city, or incorporated town in the State of Mississippi or adjacent to the main line and branch railroad of this corporation for a subscription to a specified amount of the capital stock of said corporation, said constituted authorities are hereby required without delay to submit the question of 'subscription' or 'no subscription' to the decision of the qualified voters of said county, city, or incorporated town at a special or regular election to be held therein, and if two-thirds of said qualified voters be in favor of said subscription, the constituted authorities of said counties, cities, or incorporated towns are hereby required, without delay, and are authorized and required to subscribe to the capital stock of said corporation to the amount agreed upon, and bonds of the county, city, or incorporated town making the subscription, having such time to run and such rates of interest as may be agreed upon, shall be issued without delay by the authorities of the counties, cities, or incorporated towns, to the president and directors of said corporation, to the amount of said subscription to the capital stock. . . ."
The second act recited had the effect merely to change the
name of the company to that of "The Greenville, Columbus and Birmingham Railroad Company."
The complaint alleged that the bonds and coupons described were delivered by the County of Carroll to the railroad company for value, and that the plaintiff became a purchaser thereof for a valuable consideration before maturity and was an innocent holder thereof without notice.
The defendant pleaded three pleas, of which the first in order is as follows:
"And for further plea in this behalf, said defendant, by attorney, says action non, because it says that on the 3d day of March, 1873, on the application of the president of the Greenville, Columbus and Birmingham Railroad Company, a corporation in this state, the Board of Supervisors of the County of Carroll ordered a special election to be held in said county on the 1st day of April, 1873 at which the question of subscription or no subscrption, by said county, to the capital stock of said railroad company was to be submitted to the qualified voters of said county. And said defendant avers that said election was accordingly held, and said defendant avers that on the 1st day of April, 1873, the names of 3,129 registered voters were on the registration books of said county, and there were in fact on the 1st day of April, 1873, three thousand one hundred and twenty-nine qualified voters in said county, but that only 1,280 of said voters voted at said election, of whom 918 voted in favor of the proposition to subscribe for said stock and 362 voted against it, as fully appears by the returns of the three registrars of said county, filed with the clerk of said board of supervisors of said county. And said defendant says that notwithstanding the refusal of two-thirds of the qualified voters of said county to vote in favor of subscription for stock, the then board of supervisors of said county, in violation of their duty and the trusts reposed in them and in violation of the Constitution of the State of Mississippi, subscribed to the capital stock of said railroad company and issued the bonds and coupons in the declaration mentioned in fact for said subscription for said capital stock in said railroad company, without any statement or recital in said bonds that two-thirds of the qualified voters of said county had assented thereto. And this the said defendant is ready to verify. Wherefore it prays judgment,"
The second was like the first, with the additional averments that the said returns of the registrars of the county, filed and deposited with the clerk of the said board of supervisors of said county, was
"at all times open to the inspection of all persons in the public office of the clerk of the chancery court of said county, and said defendant avers that the said registration of voters of said county was a book of record, deposited and kept in the public office of the clerk of the chancery court of said county as a record book, and open for inspection to all persons, and exhibited the fact that there were 3,129 registered voters in said county at the time of the election."
The third plea was like the second, with the addition of the following:
"And said defendant avers that before the issuance of any of the bonds and coupons in the declaration mentioned, a bill was exhibited by citizens and taxpayers of said county against the said board of supervisors in the Chancery Court of the County of Carroll to restrain and enjoin said board of supervisors from the issuance and delivery of the bonds of said county upon a subscription of stock in said railroad company, and thereupon an injunction was ordered and issued, before the issuance and delivery of any of the bonds and coupons mentioned in the declaration, restraining and enjoining the said board of supervisors from the issuance and delivery of such bonds. And said defendant avers that the said bill of injunction was sustained and made perpetual by the judgment and decree of the Supreme Court of the State of Mississippi. And said defendant says that notwithstanding the issuance and pendency of said injunction and notwithstanding the refusal of two-thirds of the qualified voters of said county to vote for said subscription for stock in said railroad company, the said board of supervisors fraudulently and illegally issued and delivered the bonds and coupons in the declaration mentioned in fact for a subscription for stock in said railroad company. And this the said defendant is ready to verify. Wherefore it prays judgment."
A demurrer to each of these pleas was sustained, and judgment rendered for the plaintiff below, to reverse which this writ of error is prosecuted.


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Food workers unions are on the rise, and Los Angeles workers have made major advances that could affect restaurants here and beyond. Korean and Latino workers in Genoa ratified their first union contract in June, which advocates say could become a model for immigrant restaurant workers in Los Angeles and beyond.
In 2020, the California Labor Commissioner’s Office cited the owners of Genwa Korean BBQ restaurant for violating labor laws that affected 325 dishwashers, servers, and chefs at their Beverly Hills and Mid-Wilshire locations. The $2.1 million fine (which was later reduced in a settlement) was imposed as punishment for work violations such as no rest and meal breaks, unpaid overtime, and less than minimum wage pay.
For decades, restaurant workers across Los Angeles have accused owners of exploitation through wage theft and abuse. The NBC News story reported that the agreement between Genwa workers — which includes employees at all three Genwa restaurants in Los Angeles — includes healthcare reimbursement, rehiring workers laid off after February 2020, salary increases, seniority rights, sexual harassment training, retirement plans, and equal distribution. To tip and conflict resolution process. It is possible that with the implementation of this new labor agreement, restaurant workers in the city may have a new standard for wages and working conditions.
Bobby Flay in Los Angeles
It’s always nice to see Los Angeles restaurants get some love, especially in the form of Food Network shows featuring Bobby Flay and his daughter all over the California coast. Bobby and Sophie on the coast The LA hotspot features Jitlada, Salt’s Cure, Mashti Malones, and Roscoe’s Chicken and Waffles. Streaming on Discovery+ starting August 22nd, reporting deadline.
Chilean grasshopper croissant
The LA Taco crew ventured to Cha Cha Chá in the Arts District for the perfect Los Angeles story. They sampled the restaurant’s croissants made by the Salvadoran-born chef in Watts who owns Needed Bakers, featuring a chili/grasshopper croissant. It is available for brunch.
How Hanchic and Holy Basil reshape the scene
Los Angeles food writer Andy Wang wrote an article for The Robb Report in which he suggests that the Asia-owned and operated Hancock and Holly Basil “represent the future of Asian-American food in Los Angeles”.
Bastille Day Celebrations in Los Angeles
If you’re planning to celebrate French Bastille Day in Los Angeles, head to Simonette at Palihotel Culver City on July 14 for all-day menus. Reservations are recommended. Ospero from Wolfgang Puck also celebrates Fête Nationale Française with a special menu. Beverly Hills newcomer Velverie Cafe and Teahouse is also jumping into today’s festivities, too. Tesse also has a $65 fixed price list.


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IAP antagonists induce anti-tumor immunity in multiple myeloma.
ABSTRACT: The cellular inhibitors of apoptosis (cIAP) 1 and 2 are amplified in about 3% of cancers and have been identified in multiple malignancies as being potential therapeutic targets as a result of their role in the evasion of apoptosis. Consequently, small-molecule IAP antagonists, such as LCL161, have entered clinical trials for their ability to induce tumor necrosis factor (TNF)-mediated apoptosis of cancer cells. However, cIAP1 and cIAP2 are recurrently homozygously deleted in multiple myeloma (MM), resulting in constitutive activation of the noncanonical nuclear factor (NF)-?B pathway. To our surprise, we observed robust in vivo anti-myeloma activity of LCL161 in a transgenic myeloma mouse model and in patients with relapsed-refractory MM, where the addition of cyclophosphamide resulted in a median progression-free-survival of 10 months. This effect was not a result of direct induction of tumor cell death, but rather of upregulation of tumor-cell-autonomous type I interferon (IFN) signaling and a strong inflammatory response that resulted in the activation of macrophages and dendritic cells, leading to phagocytosis of tumor cells. Treatment of a MM mouse model with LCL161 established long-term anti-tumor protection and induced regression in a fraction of the mice. Notably, combination of LCL161 with the immune-checkpoint inhibitor anti-PD1 was curative in all of the treated mice.
Project description:The inhibitor of apoptosis (IAP) proteins have a critical role in the control of apoptotic machinery, and has been explored as a therapeutic target. Here, we have examined the functional importance of IAPs in multiple myeloma (MM) by using a Smac (second mitochondria-derived activator of caspases)-mimetic LCL161. We observed that LCL161 was able to potently induce apoptosis in some MM cell lines but not in others. Examining the levels of X-linked inhibitor of apoptosis protein (XIAP), cellular inhibitor of apoptosis protein 1 (cIAP1) and cellular inhibitor of apoptosis protein 2 (cIAP2) post LCL161 treatment indicated clear downregulation of both XIAP activity and cIAP1 levels in both the sensitive and less sensitive (resistant) cell lines. cIAP2, however, was not downregulated in the cell line resistant to the drug. Small interfering RNA-mediated silencing of cIAP2 significantly enhanced the effect of LCL161, indicating the importance of downregulation of all IAPs simultaneously for induction of apoptosis in MM cells. LCL161 induced marked up regulation of the Jak2/Stat3 pathway in the resistant MM cell lines. Combining LCL161 with a Jak2-specific inhibitor resulted in synergistic cell death in MM cell lines and patient cells. In addition, combining LCL161 with death-inducing ligands clearly showed that LCL161 sensitized MM cells to both Fas-ligand and TRAIL.
Project description:We demonstrated sensitization for chemotherapy by Smac mimetic (SM) LCL161, a potent antagonist of inhibitor of apoptosis proteins (IAP), in neuroblastoma (NB). Vinca alkaloids, particularly vincristine (VCR), displayed the strongest impact on inhibition of proliferation and apoptosis induction in combination with LCL161. The underlying signaling pathways remain elusive, though. LCL161 induces a quick degradation of cellular IAP 1 (cIAP-1). Combination of LCL161 with VCR had only marginal effects on X-linked IAP (XIAP) protein expression. Cell death is accompanied by activation of intrinsic (caspase-9 and MMP) and extrinsic (caspase-8) pathways of apoptosis, repression of migratory potential and cell cycle arrest in G2 phase. LCL161-induced cIAP degradation leads to activation of non-canonical and blockade of canonical NF-?B pathways but not induction of apoptosis. Surprisingly NF-?B and TNF-? signaling is negligible for VCR- and VCR/LCL161-induced apoptosis since chemical inhibition of NF-?B using BAY-7085 and PBS-1086, as well as application of TNF-? blocking antibody Humira (adalimumab) has no relevant effect on cell death. Recently formation of a TNF-?-independent complex (ripoptosome) consisting of RIP1, FADD and caspase-8 following IAP inhibition by SM has been described. However, targeting of RIP1 by Necrostatin was not sufficient to influence apoptosis induced by VCR/LCL161.
Project description:Host cells infected with obligate intracellular bacteria Chlamydia trachomatis are profoundly resistant to diverse apoptotic stimuli. The molecular mechanisms underlying the block in apoptotic signaling of infected cells is not well understood. Here we investigated the molecular mechanism by which apoptosis induced via the tumor necrosis factor (TNF) receptor is prevented in infected epithelial cells. Infection with C. trachomatis leads to the up-regulation of cellular inhibitor of apoptosis (cIAP)-2, and interfering with cIAP-2 up-regulation sensitized infected cells for TNF-induced apoptosis. Interestingly, besides cIAP-2, cIAP-1 and X-linked IAP, although not differentially regulated by infection, are required to maintain apoptosis resistance in infected cells. We detected that IAPs are constitutively organized in heteromeric complexes and small interfering RNA-mediated silencing of one of these IAPs affects the stability of another IAP. In particular, the stability of cIAP-2 is modulated by the presence of X-linked IAP and their interaction is stabilized in infected cells. Our observations suggest that IAPs are functional and stable as heteromers, a thus far undiscovered mechanism of IAP regulation and its role in modulation of apoptosis.
Project description:Smac mimetic compounds (SMCs) are anti-cancer drugs that antagonize Inhibitor of Apoptosis proteins, which consequently sensitize cancer cells to death in the presence of proinflammatory ligands such as tumor necrosis factor alpha (TNF-?). SMCs synergize with the attenuated oncolytic vesicular stomatitis virus (VSV?51) by eliciting an innate immune response, which is dependent on the endogenous production of TNF-? and type I interferon. To improve on this SMC-mediated synergistic response, we generated TNF-?-armed VSV?51 to produce elevated levels of this death ligand. Due to ectopic expression of TNF-? from infected cells, a lower viral dose of TNF-?-armed VSV?51 combined with treatment of the SMC LCL161 was sufficient to improve the survival rate compared to LCL161 and unarmed VSV?51 co-therapy. This improved response is attributed to a bystander effect whereby the spread of TNF-? from infected cells leads to the death of uninfected cells in the presence of LCL161. In addition, the treatments induced vascular collapse in solid tumors with a concomitant increase of tumor cell death, revealing another mechanism by which cytokine-armed VSV?51 in combination with LCL161 can kill tumor cells. Our studies demonstrate the potential for cytokine-engineered oncolytic virus and SMCs as a new combination immunotherapy for cancer treatment.
Project description:BACKGROUND:Mechanisms by which Smac mimetics (SMs) interact with proteasome inhibitors (e.g., bortezomib) are largely unknown, particularly in multiple myeloma (MM), a disease in which bortezomib represents a mainstay of therapy. METHODS:Interactions between the clinically relevant IAP (inhibitor of apoptosis protein) antagonist birinapant (TL32711) and the proteasome inhibitor bortezomib were investigated in multiple myeloma (MM) cell lines and primary cells, as well as in vivo models. Induction of apoptosis and changes in gene and protein expression were monitored using MM cell lines and confirmed in primary MM cell populations. Genetically modified cells (e.g., exhibiting shRNA knockdown or ectopic expression) were employed to evaluate the functional significance of birinapant/bortezomib-induced changes in protein levels. A MM xenograft model was used to evaluate the in vivo activity of the birinapant/bortezomib regimen. RESULTS:Birinapant and bortezomib synergistically induced apoptosis in diverse cell lines, including bortezomib-resistant cells (PS-R). The regimen robustly downregulated cIAP1/2 but not the canonical NF-?B pathway, reflected by p65 phosphorylation and nuclear accumulation. In contrast, the bortezomib/birinapant regimen upregulated TRAF3, downregulated TRAF2, and diminished p52 processing and BCL-XL expression, consistent with disruption of the non-canonical NF-?B pathway. TRAF3 knockdown, ectopic TRAF2, or BCL-XL expression significantly diminished birinapant/bortezomib toxicity. The regimen sharply increased extrinsic apoptotic pathway activation, and cells expressing dominant-negative FADD or caspase-8 displayed markedly reduced birinapant/bortezomib sensitivity. Primary CD138+ (n?=?43) and primitive MM populations (CD138-/19+/20+/27+; n?=?31) but not normal CD34+ cells exhibited significantly enhanced toxicity with combined treatment (P?<?0.0001). The regimen was also fully active in the presence of HS-5 stromal cells or growth factors (e.g., IL-6 and VEGF). Finally, the regimen was well tolerated and significantly increased survival (P?<?0.05 and P?<?0.001) compared to single agents in a MM xenograft model. Combined treatment also downregulated cIAP1/2 and p52 while increasing PARP cleavage in MM cells in vivo. CONCLUSIONS:Our data suggest that birinapant and bortezomib interact synergistically in MM cells, including those resistant to bortezomib, through inactivation of the non-canonical NF-?B and activation of the extrinsic apoptotic pathway both in vitro and in vivo. They also argue that a strategy combining cIAP antagonists and proteasome inhibitors warrants attention in MM.
Project description:Monocytes and macrophages constitute the first line of defense of the immune system against external pathogens. Macrophages have a highly plastic phenotype depending on environmental conditions; the extremes of this phenotypic spectrum are a pro-inflammatory defensive role (M1 phenotype) and an anti-inflammatory tissue-repair one (M2 phenotype). The Inhibitor of Apoptosis (IAP) proteins have important roles in the regulation of several cellular processes, including innate and adaptive immunity. In this study we have analyzed the differential expression of the IAPs, NAIP, cIAP1 and cIAP2, during macrophage differentiation and polarization into M1 or M2. In polarized THP-1 cells and primary human macrophages, NAIP is abundantly expressed in M2 macrophages, while cIAP1 and cIAP2 show an inverse pattern of expression in polarized macrophages, with elevated expression levels of cIAP1 in M2 and cIAP2 preferentially expressed in M1. Interestingly, treatment with the IAP antagonist SMC-LCL161, induced the upregulation of NAIP in M2, the downregulation of cIAP1 in M1 and M2 and an induction of cIAP2 in M1 macrophages.
Project description:Proteasome inhibitors have achieved clinical success because they trigger intrinsic and extrinsic cell death to eliminate susceptible human cancers. The ubiquitin-proteasome protein degradation system regulates signaling pathways by controlling levels of components such as cellular inhibitor of apoptosis (cIAP)1 and cIAP2 in TNF-mediated cell death. Here, we sought to evaluate the contribution of necroptosis to the cell death pattern induced by the specific proteasome inhibitor Carfilzomib (Cf). Proteasome inhibitor-sensitive multiple myeloma cell lines die in response to Cf by apoptosis in combination with serine protease-dependent death, without any contribution of RIPK3-dependent necroptosis. Proteasome inhibition leads to the induction of apoptotic markers such as activated caspase-3 rather than necroptotic markers such as phosphorylated-MLKL in all cell lines tested. In HT-29 cells, Cf attenuates the late RIPK1 interaction with TNFR1 during TNF-induced necroptosis without altering the sensitivity of cIAP antagonists. Cf treatment results in decreased translocation of death signaling components RIPK1, FADD, caspase-8, cFLIP, and RIPK3 to detergent insoluble fractions. Our results show that proteasome inhibition with Cf impairs necroptosis and favors apoptosis even in cells with intact necroptotic machinery. Following the induction of TNFR1-mediated necroptosis, proteasome activity stabilizes effective aggregation and activation of ripoptosome/necrosome complexes.
Project description:The larval stage of Echinococcus granulosus sensu lato, resulting in cystic echinococcosis, a parasitic zoonosis, causes huge economic losses to the livestock industry and poses a threat to public health. Inhibitor of apoptosis proteins (IAPs) is a class of endogenous anti-apoptotic family, which plays a significant functional role in the regulation of organism's development. Herein, to explore potential functions of IAPs in E. granulosus, two members of IAPs from E. granulosus (Eg-IAP and Eg-BIRP) were cloned, expressed, and molecularly characterized. Eg-IAP and Eg-BIRP encoded putative 331 and 168 residue proteins, respectively. Bioinformatic analysis showed that both proteins contained a type II BIR domain-the essential functional domain of IAPs. Fluorescence immunohistochemistry revealed that both proteins were ubiquitously localized in all life-cycle stages of E. granulosus. Our fluorescent quantitative PCR (RT-qPCR) results revealed relatively higher transcription levels of two Eg-IAPs in protoscoleces (PSCs) compared to the 18-day strobilated worms. We further used different concentrations of LCL161, a Smac-mimetic pan-IAPs inhibitor, to induce the apoptosis in PSCs in vitro, and revealed that the survival rate of PSCs and transcription levels of both genes were negatively correlated with the concentration of LCL161. While the results of light microscopy, transmission electron microscopy (TEM), and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay also showed a higher apoptotic rate in PSCs with the increasing concentrations of LCL161. Taken together, our findings provide the reasonable evidence that both Eg-IAP and Eg-BIRP have potential implication in critical anti-apoptotic roles during the development of E. granulosus.
Project description:Extracellular acidification is a very common cause of stress in tumor microenvironment and of Darwinian pressure. In acid areas of the tumor, most cancer cells are-albeit slowly proliferating-more resistant to cell death than those in well-perfused regions. Tumor acidosis can directly regulate the expression of pro-survival proteins since a low extracellular pH activates the caspase-dependent cell death machinery. This mechanism has never been explored in bone sarcomas. We cultured osteosarcoma and Ewing sarcoma cells under low pH (pH 6.5), and we performed deep-sequencing and protein analysis. Both in in vitro and in vivo models, acidification activity enhanced tumor cells survival. However, we did not observe any change in ERK1 phosphorylation. On the contrary, both at the mRNA and protein level, we found a significant induction of TRAF adaptor proteins and of cIAP proteins (BIRC2 and/or BIRC3). As a consequence, the downstream nuclear transcription factor kappa B (NF-?B) survival pathway was increased. Furthermore, the treatment with the cIAP inhibitor LCL161 reverted the protection from apoptosis under low pH. In vitro results were confirmed both in Ewing sarcoma xenograft and in osteosarcoma patients, since the analysis of tumor tissues demonstrated that the levels of expression of TRAF1 or NF-?B1 significantly correlate with the level of expression of the vacuolar ATPase (V-ATPase), the most important proton pump in eukaryotes. Moreover, in the tissue sections of xenograft model, the nuclear translocation of RelB, a key subunit of the NF-?B transcriptional complex, localized in the tumor region that also corresponded to the acid microenvironment associated with the highest levels of expression of LAMP2 and V-ATPase, in the internal area of the tumor, as revealed by immunohistochemistry. Our data confirm that tumor acid microenvironment activates a stress-regulated switch to promote cell survival of bone sarcoma, and support the hypothesis that this mechanism is mediated by the recruitment of TRAF/cIAP complexes. Altogether, these results suggest that TRAF/cIAP can be considered as a target for anti-cancer therapies.
Project description:PTEN loss is prognostic for patient relapse post-radiotherapy in prostate cancer (CaP). Infiltration of tumor-associated macrophages (TAMs) is associated with reduced disease-free survival following radical prostatectomy. However, the association between PTEN loss, TAM infiltration and radiotherapy response of CaP cells remains to be evaluated. Immunohistochemical and molecular analysis of surgically-resected Gleason 7 tumors confirmed that PTEN loss correlated with increased CXCL8 expression and macrophage infiltration. However PTEN status had no discernable correlation with expression of other inflammatory markers by CaP cells, including TNF-?. In vitro, exposure to conditioned media harvested from irradiated PTEN null CaP cells induced chemotaxis of macrophage-like THP-1 cells, a response partially attenuated by CXCL8 inhibition. Co-culture with THP-1 cells resulted in a modest reduction in the radio-sensitivity of DU145 cells. Cytokine profiling revealed constitutive secretion of TNF-? from CaP cells irrespective of PTEN status and IR-induced TNF-? secretion from THP-1 cells. THP-1-derived TNF-? increased NF?B pro-survival activity and elevated expression of anti-apoptotic proteins including cellular inhibitor of apoptosis protein-1 (cIAP-1) in CaP cells, which could be attenuated by pre-treatment with a TNF-? neutralizing antibody. Treatment with a novel IAP antagonist, AT-IAP, decreased basal and TNF-?-induced cIAP-1 expression in CaP cells, switched TNF-? signaling from pro-survival to pro-apoptotic and increased radiation sensitivity of CaP cells in co-culture with THP-1 cells. We conclude that targeting cIAP-1 can overcome apoptosis resistance of CaP cells and is an ideal approach to exploit high TNF-? signals within the TAM-rich microenvironment of PTEN-deficient CaP cells to enhance response to radiotherapy.


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In the heart of Mecklenburg-Vorpommern district, Boltenhagen is a delightful German seaside resort. It may be the big hip cities like Berlin, Dusseldorf and Frankfurt that get all of the attention when it comes to traveling in Germany, but the small towns are every bit as charming and provide a great insight into local life and traditions.
Naturschutzgebiet Tarnewitzer Huk is a beautiful beach and coastal walk on the outskirts of Boltenhagen that is well worth a visit for a quiet afternoon. The beautiful Schloss Bothmer is an 18th-century grand palace that has been transformed into a living museum which can be toured for a small fee.
The summer months of June through to August are the best time to visit Boltenhagen in order to try to catch the best of the summer sun and hot weather.
Browse accommodations from all the best providers including Homeaway, Airbnb, priceline and more at AllTheRooms.com. Boltenhagen has 994 hotels, vacation rentals and other unique places to stay, with prices to suit budget travelers, luxury travelers and everything in between. For those trying to keep costs down, the lowest priced place to stay in Boltenhagen comes in at $36 per night. The average price of accommodation in is $121 per night.
If you need an internet connection during your stay in Boltenhagen, then you can choose from over 302 places to stay that provide WiFi internet. 7 of our accommodations in include a breakfast in the price. Driving to Boltenhagen? Then choose one of the 321 places to stay that comes with a parking spot included.
AllTheRooms has 136 pet-friendly places to stay in Boltenhagen, so if you're travelling with your cat or dog you won't have any trouble.
In Boltenhagen AllTheRooms currently aggregates hotels, vacation rentals, hostels from more than 6 providers, including 319 places to stay from Homeaway, 43 accommodations from Airbnb and 43 places to stay from priceline.
323 of our places to stay in Boltenhagen have been rated by previous guests. They rated 27% as excellent or good. 449 accommodations allow instant booking.

domain: geography


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Suzanne Scurlock-Durana, the author of “Reclaiming Your Body,” visits the show for a conversation around trauma and healing from the core.
Healing from the Core (Opening) – The two begin by discussing the impact of traumatic events in our lives, big and small. This includes the kind of trauma that comes from things that should have happened for us and never did.
“The thing that most people don’t recognize is that the things that should have happened, but did not. That emptiness often is what causes us to feel as though something is really wrong. It is almost like it’s the things that didn’t happen, but should have, versus the things that did happen that were awful. Both of these cause trauma for us, small and large.” – Suzanne Scurlock-Durana
Awakening to Your Body’s Wisdom (7:05) – Suzanne talks about our body’s innate wisdom that provides us with the capacity to heal from our trauma.
“All of this wisdom comes bubbling up from the body and informs the brain. What we are now seeing in recent research is that a lot of what goes on in the brain is coming from input from the body which is beyond normal sensory input.” – Suzanne Scurlock-Durana
Unresolved Trauma (24:25) – Chris and Suzanne discuss the research on how unresolved trauma impacts our lives. They talk about the ways in which traumatic events continue to affect the body after the event occurs.
From the Head to the Heart (32:30) – When approaching trauma, it is easy to focus primarily on what is going on in the mind. Suzanne explores why it is just as important to focus on healing the heart and opening ourselves fully to its tenderness.
“As a culture, we have moved out of our bodies. The speed we go at; the amount of technology we have; the amount of multitasking that goes on; the trauma; all of these things hinder us from being in the present moment in our bodies. My point is that it is our birthright to know how to consciously move back to our bodies and the tremendous amount of wisdom and gifts they have for us. The inspiration of the heart when it wakes up is just exquisite.” – Suzanne Scurlock-Durana
Find Suzanne Scurlock-Durana online. For more wisdom on healing from the core, check out this episode from RamDev.
Photo via Suzanne Scurlock-Durana

domain: psychology


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Item #: R-Y-VR-05 -
Availability: In Stock
A full set of race graphics for the Yamaha M1 used Valentino Rossi 2005 Moto GP Valencia Race Bike. Turn your bike into a race replica or simply use them wherever you want! Precision die cut printed vinyl decals laminated for long life and durability. These are high quality long lasting decals.

domain: sports


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A lottery is a process of allocating something of value, often money, by chance. There are many different types of lotteries, including those run by state or federal governments. The financial lottery is the most familiar example; people pay a small amount of money for a chance to win a large sum. Other examples are sports team drafts and the allocation of scarce medical treatment. The lottery is a popular form of gambling and can have negative effects on society.
One argument used to promote the lottery is that it is a good way to raise revenue without raising taxes. However, this claim is misleading. The majority of lottery revenues are generated by the small percentage of people who play. The lottery is also a very expensive enterprise. In addition to the expense of running the lottery, there are also significant administrative costs associated with paying out winnings. In the rare case that someone does win, he or she will likely face enormous tax consequences. This will probably require him or her to spend most of the prize money and may cause him or her to go bankrupt within a few years. The average American family spends over $80 billion a year on lotteries, and this is an excessive waste of resources. Instead, Americans should use this money to build an emergency fund or pay off credit card debt.
The odds of winning a lottery are very low, but most people still try to increase their chances of winning by playing multiple times per week. There are a few key strategies that can help players improve their odds of winning, but most importantly, people need to understand the rules of probability. They should also avoid the temptation to buy a ticket for the numbers that have come up frequently in the past.
It is important to understand the odds of winning a lottery, and how they change over time. The most common misconception is that the odds of a number being selected are the same for every single draw. This is not true, and it can lead to many bad decisions by players.
Another common mistake is to assume that the number of winning tickets is proportional to the amount of money paid for a ticket. This is also not true, and it can lead to false conclusions about the likelihood of winning.
Lotteries are a controversial form of gambling that involves a random selection of winners for a prize. In some cases, government agencies will hold a lottery to allocate limited resources such as housing units, kindergarten placements, or even sports team drafts. In other cases, private businesses will hold a lottery to distribute dividends to shareholders. Lotteries have been used as a method of raising money for both public and private projects in Europe since the early 15th century. During the colonial era, lotteries played a large role in funding churches, colleges, roads, canals, and bridges. Benjamin Franklin even held a lottery to raise money for cannons to defend Philadelphia against the British during the Revolutionary War.

domain: finance


MIAMI (AP) – Tropical Depression Emily is moving out over the Atlantic early Tuesday, a day after slogging across the Florida peninsula, where it brought drenching rain and power outages.
The depression’s maximum sustained winds are near 30 mph.
Strengthening is possible during the day but the poorly-organized depression is expected to stop being a tropical system within a day or two.
The depression is centered about 50 miles north-northeast of Vero Beach, Florida, and is moving east-northeast near 12 mph.
As Tropical Depression Emily pushes off Florida’s east coast, the wind flow around the storm is helping to lower rain chances. Upper-level dry air is being pulled across the Tampa Bay area on the backside of Emily.
“You may even notice slightly lower humidity this morning, but the best news is that it will lower our rain chances and give us a day to dry out,” said Storm Team 8 Meteorologist Leigh Spann.
The drier air will not last long. Humidity and rain chances increase again Wednesday.
Tropical Storm Emily made landfall on Anna Maria Island Monday morning. Storm Team 8 Chief Meteorologist Steve Jerve says that Tropical Storm Emily made landfall at 10:45 a.m.
High winds from the storm closed the Sunshine Skyway Bridge.
Tropical Storm Emily had boat owners in Manatee and Sarasota counties scrambling to secure their boats.
Streets were flooded in Pinellas, Polk, Manatee and Sarasota counties.
One mobile home park in Lakeland remained flooded the day after Emily moved through.
- Sarasota, Manatee counties hit hard
- Roof blows off Fort Myers Resort
- Lakeland mobile home park flooded following Tropical Storm Emily
- Gov. Scott declares state of emergency for Tropical Storm Emily
- Tropical Storm Emily weakens to depression over central Florida
- See your full forecast here
- Download the Storm Team 8 Weather Max app here


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Hi there people, our latest update coloring sheet which you can have some fun with is Baby Swans Coloring Pages, posted on Swans category. This coloring sheet meassure is about 600 pixel x 373 pixel with approximate file size for around 50.76 Kilobytes.
To get more sheet similar to the picture right above you, you can surf the following Related Images section on the bottom of the post or browsing by category. You could find lots of other enjoyable coloring picture to obtain. Have a good time!

domain: hobby


inspection with drones
The future of industrial inspection will not require scaffolding, ropes or rigs. Fourfang offers a fully automated, low cost and highly effective inspection method with the Olympus and Venus. There will be no more extra risks to your operators, or to shut down your machinery or towers to get accurate data about your infrastructure. Work can continue as usual while the Venus scans for an anomaly in the machinery. If there is any faulty parts or damages to the infrastructure, Venus will report back to you immediately, with an instant notification. With the real-time data on your fingertips, you are in control of scheduling the next maintenance and there will no more preventable accidents.
Fourfang’s fully automated drone solution provides easy, reliable, accurate and cost-effective inspection results to you, constantly.


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The Royal Australian Navy (RAN) has named of its future fleet replenishment/ support ships as Supply and Stalwart, the country’s Minister for Defence, Marise Payne announced on Nov. 17.
Supply will be the second vessel in the Royal Australian Navy to bear the name that has its origins with the armed tender ship that accompanied the First Fleet to Australia. Stalwart is being named after two previous Australian Navy vessels, one a destroyer that served between 1920 and 1925 and the second destroyer tender served from 1968 to 1990.
The ships will be known as Auxiliary Oiler Replenishment (AOR) vessels and will replace the current HMA ships, HMAS Success and HMAS Sirius.
“In considering names for classes and ships, the Navy chose names with deep historical roots or names that are uniquely Australian,” Minister Payne said. “For these ships, we have been able to achieve both. Supply was instrumental in establishing the British colony and Stalwart, like the Australian Navy itself, has its origins in the Royal Navy and subsequently two Australian ships.”
Minster Payne said that today the Chief of Navy, Vice Admiral Tim Barrett, will conduct the tradition of placing a coin in the ship at the keel laying at the Navantia shipyard in Ferrol, Spain. “When these ships enter service from 2020, they will be an important part of the future fleet that the government has committed to in the 2016 Defence White Paper,” Minister Payne added.
Supply will be built in two years, with full operational capability scheduled for 2022.
Royal Australian Navy

domain: politics


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I love working on commissioned assignments! I’m a proper chameleon and can relate to all kinds of different audiences, but always keep my own style, which is of course why I’m asked.
What can I do for your company?
You can contact me to design patterns, prints and products for you. I am experienced in designing complete style concepts/trend prognoses for home accessory collections. And I’ve done several art direction projects for websites, which is definitely my cup of tea!
On my blog I share my comissioned work on a regular basis.
Are you interested or do you have a question? Send me an email via [email protected] And then we look together at what the possibilities are.

domain: design


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(CN) - Concordia International Corp. lost a bid to dismiss a class action launched by investors in New York's Southern District.
Canadian-based Concordia was sued by investors in a December 2016 class action over the drug donnatal, used for irritable bowel syndrome, which Concordia bought the rights to for $200 million in cash and 4.6 million in shares from PBM Pharmaceuticals Inc. in March 2014.
Investors alleged that Concordia executives caused 75-80 salespeople, roughly half of their salesforce hired to sell donnatal, to be fired without any explanation, and failed to inform them that several insurance companies terminated or decreased their formulary coverage of donnatal. Investors also accused the execs of touting the company's financial performance in an Aug. 3, 2016 press release, claiming that they "knew very well that the company would be facing a serious cash crunch." Concordia moved to dismiss the claims on Feb. 20, 2017.
In his ruling, U.S. District Judge Richard M. Berman agreed with investors that terminating a portion of its salesforce that accounted for over 10% of Concordia's revenue was cause for concern and should have been divulged. Berman found that the Concordia defendants were "unpersuasive" in their efforts to demonstrate that the salesforce terminations were not material to investors. In addition, he ruled that investors should have been properly informed about terminations and changes made to formulary coverage by third-party insurance providers despite the defendants' assertions that the changes were public knowledge.
However, the judge rejected investors' claims that the defendants made fraudulent statements in a press release boasting the company's financial strength, finding they were not actionable and were "too general to cause a reasonable investor to rely upon them."
The motion to dismiss by the Concordia defendants was granted in part and denied in part. A settlement conference is scheduled for Sept. 13, 2017.

domain: economics


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Why books provide the perfect backdrop to a creative workspace
And coffee of course!
A workspace in progress
At the moment I spend most of my time working at our kitchen table. I have two young children and by the time I scoop them out to nursery and race back to the house I simply lift my laptop, sit down, and try to make the most of the little bit of child-free time I have. For the last year our kitchen garden has been a work in progress but we recently painted the walls (finally some colour) and I love looking up at my bookcases and my garden; so much nicer than looking down at the sight of toys on the floor!
My typical workday
At the moment I work two days a week as I slowly make the transition from full-time employment and maternity leave to the world of freelancing. This means that I have to make every minute count. I usually write a to do list and empty my inbox the evening before, so that I can get on with the tasks in hand. When I’m editing I like to work fast and then get up and have a walk around (usually a walk to the bottom of our garden to empty the compost) and then a calm and steady final edit to make sure I haven’t missed anything. When I’m working on ideas I often take my notebook outside or into my sunny living room to give my brain a fresh perspective and get away from the computer.
Books, Books, Books
My house is bursting at the seams with books. As an editor I would frequently sift through them when trying to come up with ideas in the same way that some people search on the internet. With a mix of old and new editions and lots of different genres: literary fiction, philosophy, politics, art, photography, French science fiction (my husband’s) and kids’ story books, I’m reminded that there is always another way to think about things, allowing me to constantly seek new inspiration.
Getting out of the house
I used to spend a lot of my time in author meetings and my favourite places to have these were the British Library, the British Museum, or the LSE Bookshop. Authors always loved these environments and after meetings I would typically sit down with my laptop and finish my day. I love the buzz of other people working around me, but also the quiet and the sense of history that these places bring, as well as the secret hope that someone near me might be working on the next great literary masterpiece.
Finding what suits you
I have lots of friends who can spend all day every day working in a café, which I used to try to do just to get me out of the house. I often found it very distracting though, especially when I was working on complicated proposals, writing, or had to make phone calls to authors. When I discovered our amazing local library where I used to live in Dalston it transformed my working day. I would spend half the day at home and half in the library (which is free of course — a massive bonus). I loved getting out of the house and being around other people, but also the quiet sense of industry there. Cafés are great for lots of people but when I was working full time remotely the local library was a lifesaver!
What I can’t live without
Very simply: good coffee, good wifi (and books!). A close friend bought us a Nespresso machine as a wedding present and it is what keeps me sane at home.
Tools of the trade
I always work with a notebook by my side to jot down lists and ideas. Every few days I edit all my lists and ideas on a new page and start again. I love having beautiful notebooks and it is always the go-to present from my friends (my current favourite was a gift from The Hoxby Collective). I can never throw any of them away though as I’m too scared they contain ideas that I will never remember again, so I could probably fill an entire bookcase full of my scrappy notebooks.
Emma Hutchinson is an Associate at The Hoxby Collective and a freelance writer, editor, translator and soon-to-be life coach. She previously worked remotely for ten years as the Senior Commissioning Editor in philosophy at Polity Press, and is mum to two hectic but very lovely boys, ages one and four.
Originally published at hoxbycollective.com on May 4, 2016.

domain: artistic


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Baby Name: Tatum
From a surname which was originally derived from a place name used for girls since 1994. Actress Tatum O'Neil, best-known for her role in the 1973 movie, "Paper Moon," became the youngest actor to win an Oscar at the age of 10. It's currently listed among the top 400.
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April 12, 2012
As I’ve been looking into the issues around lawyers putting client data in the cloud, I’ve run into a fair amount of (quasi?) scholarly work on the issue. There are several organizations that have published advice on the subject, including ILTSO, ILTA and ISACA. The primary source materials come from the ABA and various state bar Ethics Committees. So far, case law is very limited, dealing more with maintaining the attorney-client privilege with email and the discoverability of client data that someone else put in the cloud. Your malpractice insurance provider may have something to say about it. And then law practice management vendors publish “White Papers” that describe why their product is a great solution for your practice.
It’s a lot of fairly complex data and it doesn’t all agree. I’ve written a couple of articles for local Colorado legal publications on how the Ethics Committees are approaching the issue. But, so far their advice has been vague and unrealistic. Clearly the users of the many law practice management systems out there (not to mention gmail, Dropbox or Docs to Go users) haven’t been paying attention to them. And until one of them has a big security breach and clients start grieving, no one will – which doesn’t mean lawyers shouldn’t care what the Ethics Committees think. It’s just that the committees aren’t very helpful for lawyers trying to make an educated decision, or use “reasonable precautions” as the opinions require.
I’ve found that some of the organizations give more practical advice. But, the reader still needs to appreciate who is involved in giving that advice. ILTA, the International Legal Technology Association, has some informative publications. It’s important to know, however, that they are provided or sponsored by the vendors of the services they are evaluating. It’s a trade organization, or as it describes itself, a ‘networking organization’.
In contrast, ILTSO, the International Legal Technical Standards Organization, has some of the same membership as the ILTA, but is focused on providing lawyers with standards that they can use to self assess their security compliance. Their standards for client data security are specific and clear, if perhaps beyond what most lawyers are doing today.
ISACA, the Information Systems Audit and Control Association, has a broader audience than just the legal profession. And think about it, other types of businesses, including health care and financial services, have many more technical security requirements to follow than lawyers. It is an independent organization that provides certification in auditing and security. ISACA has issued guidelines on adopting cloud use that lawyers can apply to the business of practicing law which shed light on the risks and rewards of this advanced technology.
Finally, a few words about white papers. The purpose of a white paper is to help you make a decision, so the author is important. They are rarely impartial. A commercial white paper is written to persuade you to choose that vendor’s product. They aren’t false, or they would be prohibited by the FTC rules on false advertising. But they are marketing materials. Think of it like a brief. It may cite cases and ethics opinions. It may also conveniently ignore various issues. Trade associations and standards organizations also have agendas. To the extent their white papers help prod vendors and users towards better practices, I trust them more. If ethics committees considered the advice of the standards organizations when they issue their opinions (and maybe they did, but it’s not apparent), they would be more practical and helpful.

domain: law


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I love Toad in the Hole Bloas and I made it for the first time not long ago. I wanted individual servings so I used two small cake tins with two fat sausages in each one. Wish I had taken a picture, as it was really cool the way the batter poofed up around the rim of the pans. Thanks for the reminder, I have to do it again soon.
I love the video, but for extra flavor I used bacon fat instead of oil.
The gravy is spot on as you say. Yumm Ymm

domain: food


LAN-Based printing from Datakit or BNS-2000 Applications
Lucent's Datakit II VCS and BNS2000 switching products play mission-critical roles in virtually every public network in the U.S. This workhorse technology addresses a wide variety of local and wide area networking requirements. In many environments, Datakit switches are the only real-time gateway to the data generated by the primary network elements. They are also the most efficient mechanism to provide access to key systems and applications by a large diverse and physically distributed user community.
The PACLABS VCL PrintServer works in conjunction with the VCL Host Server package to re-route jobs from Datakit-based printers to LAN-based alternatives. VCL PrinterServer provides a critical link in the migration of desktop systems to TCP/IP-based network architecture. The user community can be transitioned completely to the LAN, while leaving the printing configuration of their traditional applications essentially unchanged.
Transparent Yet Powerful
The VCL PrintServer presents an interface to applications that exactly resembles a standard Datakit print device. It accepts print files from these applications, then uses its internal logic and standard UNIX tools to forward the job to the appropriate LAN-based printer. The only modification required at the applications level is changing the standard printer's address (dial string) to that of the PrintServer.
The VCL PrintServer leverages the high speed and capacity of the fiber-optic VCL Host interface. As such, the platform is scalable to support a large number of concurrent print tasks. This can be an ideal solution for deployment at the regional datacenter level.
A Smooth Migration Path
VCL Print Server allows for an incremental transition of the user community onto TCP/IP LANs. Large-scale applications, which would be difficult or impossible to modify to use a new printing architecture, can move into the new environment with little or no modification required. Users can gain the convenience of the LAN without having to learn new applications or procedures. The PrintServer is based on a standard, scalable computing platform which makes this flexibility available in a very cost-effective way.
What Can the PACLABS VCL PrintServer Mean for You?
The PACLABS VCL PrintServer can serve as a key component in upgrading and modernizing mission-critical networks.
- Smooth migration to TCP/IP architecture
- Little or no modifications to existing applications
- Better return on the Datakit/BNS investment
For more information, send email to


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Today's card is a two challenge card. The Treehouse blog asked for a clean and simple card while the Color Dare blog wanted turquoise, brown and green incorporated in a card.
The brown and blue background paper is My Mind's Eye Magnolia. The remaining paper is Stampin' Up Whisper White and Certainly Celery. The image is the Friends Forever Cuttlebug embossing folder which is highlighted with Cinnamon and Turquoise Stickles. The sentiment is Stampin' Up All Holidays.
I really like this card. I'm quite enamoured with embossing folders at the moment. It is a very effective design element. The Stickles provide amazing glitter without going overboard.
I hope you enjoy this card and come back to SPI again soon.


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“I used to be in additional than talks to affix the Star Wars universe,” he said. “I joined the Star Wars universe. I used to be requested to go away the Star Wars universe.”
Lindelof had been engaged on a movie with Sharmeen Obaid-Chinoy, who directed two episodes of Ms. Marvel and is helming one of many three new films. Obaid-Chinoy’s film follows Rey Skywalker, performed as soon as once more by Daisy Ridley, as she works to build a new Jedi Order.
Though he’s not at present a part of a Star Wars film, Lindelof appears open to engaged on the franchise down the road. “Will I get again in line outdoors the membership and attempt to get again in once more? In fact,” he added. “[Star Wars] was the alpha and the omega. It’s the primary film I noticed in a movie show. I like the entire storytelling in that world. If at first you don’t succeed, attempt, attempt once more. Or once more, once more, attempt, as Yoda would say.”


Judge To Decide Whether Provisional Ballots Cast At Wrong Polling Place Should Count
A federal judge in Phoenix is deciding whether in the upcoming election the state must count provisional ballots differently than in the past.
Under the federal Help America Vote Act, if a voter shows up at a polling place to vote, but their name is not on the list, poll workers must offer that voter a provisional ballot.
In Arizona, during elections that require voters to vote in an assigned precinct, a state law prevents ballots cast in the wrong precinct from being counted. Even if a voter goes to a polling sites a few blocks away from their assigned one, the ballot will be disqualified.
In the 2012 presidential election, almost 11,000 provisional ballots in Arizona were tossed because the voter cast the ballot at the wrong precinct.
“In other words, the state of Arizona disenfranchised 11,000 Arizona citizens who properly registered to vote, took the time to vote, and presented the necessary ID to vote,” said Spencer Scharff, director of voter protection for the Arizona Democratic Party.
The Arizona Democratic Party, along with the Democratic National Committee and Democratic candidates Hillary Clinton and Senate hopeful Rep. Ann Kirkpatrick, are challenging a number of Arizona election policies in federal court — including how the state handles provisional ballots cast in the wrong precinct.
“To deny the right to vote to even one citizen who is legally entitled to vote is simply intolerable, inexcusable and unconstitutional,” Scharff said.
On Friday U.S. District Court Judge Douglas Rayes heard oral argument over whether election officials should have to count such ballots.
Attorney Joshua Kaul for the plaintiffs argued tossing those provisional ballots violates the Voting Rights Act and disproportionately impacts minority voters. Kaul said voters are likely to be confused about where to vote because in some Arizona counties polling places frequently change, as do the model of elections. For example in March and May, Maricopa County voters could vote at any polling center, but in August and November elections they must vote at their assigned precinct location.
If a voter mistakenly votes in the wrong place, the ballot they are given to fill out could list different local races, such as for the state legislature. Plaintiffs want voters’ preferences to be counted for all the races they are eligible to vote in, and only votes on races that do not pertain to their place of residence to be disqualified.
Attorney James Driscoll-MacEachron representing state election officials argued in court on Friday that the state policy was legal and properly tallying ballots cast in the wrong location would be too burdensome.
State election director Eric Spencer told KJZZ after the hearing that processing one such ballot to figure out which races the voter was eligible to vote in could take fifteen minutes to an hour, and would involve “teams of human beings, having to copy it by hand on a new ballot.”
Spencer said that process would introduce “significant possibility of human error in that copying.” He said if election officials are required to count those provisional ballots, it could take weeks to release election results.
"They have taken an inconvenience and turned it into a constitutional violation," Spencer said of the plaintiffs' challenge.
The judge is expected to rule before the November election.
The plaintiffs filed the lawsuit after some Maricopa County voters waited hours to vote in the March presidential preference election. The suit initially sought to challenge how state election officials allocated polling site locations, but that part of the suit is expected to settle.
The suit also seeks to block a new state law that makes it a felony for anyone who is not a family member, roommate or care giver to collect and turn in someone else’s ballot.


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The Tulsa Regional Chamber will host Gov. Mary Fallin for her address to the Tulsa business community. Her close partnership on significant economic development projects has been crucial to our community. The event will highlight recent victories, the historic legislative session and more.
The event is open to the public with special pricing for Chamber members. For more information, please click here.