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Dropzone is a strategy game combining elements of modern MOBA (Multiplayer Online Battle Arena) titles and features of the most classic RTSs. Production is the work of the studio SparkyPants, known among others from Civilization II, Kingdoms of Amalur: Reckonin or the series Rise of Nations. The title released for personal computers with Windows PC is available in the free-to-play model. If you like modern RTSs, download Dropzone Download and check the options offered by this game.
Dropzone Download Full PC Version
The story presented in the game Dropzone takes place in the 20th century. Humanity has become addicted to the mysterious energy from a source called the Core. In the universe, however, there is only one place where it can be obtained. It is Europe – the moon of Jupiter attacked by an alien race of Kavash. The player gains control over three pilots who control powerful battle mechs, known as Rig. The aim of the game is to defeat enemy aliens, as well as to reach the resources necessary for the life of energy. To take part in a space expedition, download Dropzone Download and stand up to the task. The solutions used in Dropzone refer in many respects to the most classic strategies played in real time. Production, however, does not have an element quite typical for this genre, which is the expansion of its own base. The creators focused instead on tactical battles, modeled on those known from the MOBA games. Each player controls three mechs, and the battles themselves are fairly small maps and last a dozen or so minutes. The task of each player is to obtain the Core located in the middle of the map, as well as to eliminate the rival. The game also generates random side quests during each duel, thanks to which additional points can be earned. If you like fighting between powerful machines, download Dropzone Download and stand at the controls of your own mech. Players have three classes at their disposal, each with different characteristics and capabilities in terms of combat and defense.
Dropzone Download Full Version Game
The player can create his own family from virtually any type of units, which will be controlled by different heroes. Before starting the struggle, it is possible to choose the most passive skills and weapon types suited to the style of the game. The units reach the battlefield from the deck of the repair and transport ship. As in other MOBA games, production has a simple development system implemented. With the advances made, mech pilots can advance to higher levels of experience and gain new abilities. Dropzone is a title designed exclusively for multiplayer games. Up to two players who take control of separate teams can participate in a maximum of one match. Thanks to the use of Sparkle Engine’s proprietary engine, the game has been adapted to intense network matches in one-on-one mode.


Today Supreme Decree 233-2022-EF was published (see the document below), which modifies the regulations of the Income Tax Law and introduces a number of changes to the legislation related to the unjustified increase in wealth and how to justify that a loan does not qualify as such.
The unjustified increase in assets occurs when Sunat detects irregularities between the declared income and the level of assets of the audited person, as well as their consumption patterns.
Taxpayers can demonstrate that the increase in consumption or in their assets is not an “unjustified income” alleging that said increase is really a loan, not subject to income tax.
The changes introduced by the Supreme Decree make it difficult to use said loans to justify that there is no such increase.
From 2023, if a person receives a loan from a “non-cooperative” country (tax haven), he must notify Sunat about said loan at the time of making the contract. Otherwise, it cannot be considered later to justify assets or expenses incurred by the taxpayer.
Likewise, the figure of “subjects without operational capacity” is created and it is established that the loans received from said persons may not be used for the aforementioned purpose.
As Roberto Casanova-Regis, a partner at KPMG Peru, explains, “the decree hardens the form of proof. The new numeral 3 introduced to article 69-A of the regulation establishes that if the loan comes from a resident of a tax haven, they must be informed about it at the time of signing the loan contract.
Casanova-Regis indicates that this seeks to prevent money laundering or irregular use of it, such as to finance terrorism, but adds that “the fact that an entity comes from a tax haven does not undermine its ability to give a loan. There are well-known banks with offices in tax havens”.
For her part, Johana Timana, partner of the PPU firm, explains that “even if the funds do not come from an entity in a tax haven, but are channeled through one, the taxpayer will also be obliged to present a communication making this known. loan to Sunat”.
According to Casanova-Regis, now it would be “generating a pseudo-presumption that if a loan comes from a tax haven, said loan “smells bad” and must be illicitly and illegally obtained.”
Timana adds that this change can cause problems, since many countries that are on the lists of non-cooperative countries (tax havens) have already made significant progress in terms of transparency and delivery of information, so, despite the fact that they are qualified as such, they have a much better position than one might believe and this would affect possible business.
Subjects without operational capacity
On the other hand, it is established that the loan will only be valid to justify that an income is not an unjustified capital increase if said money came from a subject with operational capacity.
In other words, loans will only be justified if they come from people who have the necessary funds to fund the loan they made.
Timana explains that the Sunat will establish who does or does not have operational capacity, demarcating the “ghost” entities.
“This affects the debtor because, while an entity appeals its appointment as a subject without operational capacity before Sunat, the loan they granted cannot be used to claim an unjustified non-increase in assets,” says Timana.


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Cleveland Secure Payday Loans
If you don't pay your bills on time, or miss payments, it's likely you will lose the 0 per cent promotion, secure payday loans in Tennessee.
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Cash till payday loans online additionally, you could be charged additional fees for not being able to pay back the loan.
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Each month, we look at all the happenings from the coding bootcamp world from new bootcamps to big fundraising announcements, to interesting trends, secure payday loans in Cleveland.
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When I started paying 10% of my income to my church CONSISTENTLY and giving to struggling families with kids, God began to release financial blessings in my life.
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domain: finance


The biggest known weapon in the history of the world was MOAB – Massive Ordnance Air Bust. It was developed by U.S.A in late 2000. U.S.A army’s arsenal was equipped with it since then. But it was never used in any front line battlefield until yesterday.
After it’s development and successful test in 2000, it became popular as Mother Of All Bombs. Owing to its huge weight of 21,000 pounds. It was a 30 feet non-nuclear weapon ever developed by the mankind. This massive weapon creates a blast radius stretching a mile in each direction. MOAB was made out of very thin aluminum skin to maximize the blast. In order to overcome the difficulty of guiding this massive missile towards its target, fins were attached to its tail. During the launch these fins are folded forward onto the bomb, to make a very compact design for carriage when the weapon is deployed.
The U.S military HQ in Kabul stated that it was dropped at 7:32 p.m local time on the entrance of a tunnel complex in Achin district of Nangarhar Province. From this base, only, Afghan branch of Islamic State (IS) is conducting its operation on Afghanistan soil. It was carried to maximize the destruction of IS fighters and their operational facilities. A heavy battle was taking place in this region between IS militants and Afghan forces in the recent week.U.S forces in Afghanistan are waging a parallel battle on Taliban as well as Islamic State, and helping Northern Alliance to restore government.
Image source: Click here
Trump claimed the attack as “very, very successful mission”. It was reported that there were no civilian casualties since the attack was carried out in the remote mountainous region.
On speaking about this White house press secretary, Sean spice stated that “The United States takes the fight against ISIS very seriously and in order to defeat the group we must deny them operational space, which we did….”


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Bridgwater Independent Market
Bridgwater Independent Market will be showcasing 50 of the South West’s best producers of food, craft & gifts with market stalls in the High Street and Fore Street.
There will also be live music and entertainment to enhance the market.
The market will then take place on the LAST Sunday of the month from March to October with an additional Christmas date on the 4th December.
The market will be open between 10am – 3pm

domain: economics


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The word “Allergy” derived from the Greek word which means “other work”. It is the disorder in the form of immune reaction, which makes the body irritating through continuous itching which affects more than 50% of the population nowadays. It has several causes like, food, plants, flowers, animals, dust, changing climate and many more by which several chronic diseases are occurring.
Allergy can be in any part of the body. Eyes allergy, known as allergic conjunctivitis, same as other allergic reactions, also compensates the immune system of body. When anybody have eyes allergy, then the body reacts in having dust mites, mould, pollen, etc. It releases the chemical which results in swelling and irritation. Eyes blood vessels gets swell and make the eyes red, teary and itchy.
- Stuffy and runny nose.
- Red, itching, tearing and irritation in eyes.
- Swelling in eyelids, and in nose in the nasal cavity part.
- Pain in eyes and in inner part of ears.
- Due to continuous itching and rubbing, rashes get occurred in the skin.
- Light sensitivity.
- Seasonal allergy conjunctivitis is occurred due to the pollen which generally comes from grasses, trees, and weeds.
- The chemicals, makeup, perfume are the contact conjunctivitis, which also results in eye allergy.
- Anybody having allergy from contact lenses, which makes the eyes sensitive and red.
- Dust, other climatic changes also affects the eyes known as chronic conjunctivitis.
There are number of treatments related to eyes allergies but Ayurveda is considered to be best treatment among all. Ayurvedic treatment of allergy of eyes includes several remedies such as oral tablets, eye drops, fomentation with turmeric powder and leaves of tamarind dipped in hot water, which helps in relieving pain and inflammation, and herbal medication, etc.
Take a good care of eyes by washing them with clean water. It will give you relief. Person suffering from allergy should have a proper skin test because on the basis of that only the treatment will be given.
So, if you are searching for the treatment of allergy of eyes in India, then visit Prakash Nethralaya and Panchkarma Kendra,which have the best treatment methodologies given by the experienced doctors. You will get the best and genuine treatment in affordable manner.

domain: medical


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Oak Creek Food Delivery
Have your favorite Oak Creek restaurant food delivered to your door with Uber Eats. Whether you want to order breakfast, lunch, dinner, or a snack, Uber Eats makes it easy to discover new and nearby places to eat in Oak Creek. Browse tons of food delivery options, place your order, and track it by the minute.
Find more restaurants nearby in Oak Creek.
Papa Johns Pizza (8645 South Howell Avenue)
Panera (8907 South Howell Avenue )
Toppers Pizza (South Milwaukee)
Wingstop (8750 Howell Ave)
Subway (8201 South Howell Ave)
Potbelly Sandwich Works (Oak Creek | 457)
Little Caesars (3109 S Chicago Ave)
Buffalo Wild Wings (8171 S Howell Ave)
Trattoria di Carlo
Chick-fil-A (150 W Town Square Way)
Charcoal Grill & Rotisserie (Oak Creek)
MOD Pizza (Oak Creek)
Olive Tree café
Pizza Hut (124 N Chicago Ave)
Milwaukee Classic Pizza (Milwaukee)
Meijer (171 W Town Square Way)
Jersey Mike's (8880 South Howell Ave)
Speedway (3102 South Chicago Avenue)
Dairy Queen (8770 S Howell Ave #1)
Wendy's (7940 S. Howell)
Cousins Subs (2965 S. Chicago Ave.)
Dunkin' (3103 South Chicago Ave)
Noodles & Company (8609 S Howell Ave)
Burger King (8081 South Howell Ave)
Papa Murphy's (8880 S Howell Ave Suite 1000)
Five Guys WI-0674 160 W Town Square Way
Jimmy John's (8907 S Howell Ave)
Yofresh Yogurt Cafe
Panda Express (8041 Howell Ave)
McDonald's® (Chicago & Marion)
Taco Stop MKE (South Milwaukee)
Target (Oak Creek)
Walgreens (2985 S Chicago Ave)
PetSmart (Oak Creek)
Starbucks (Howell & Puetz)
Taco Bell (8261 S. Howell Ave.)
Qdoba Mexican Eats (8750 S. Howell Avenue)
Wild Burger (8171 S Howell Ave.)
Rosati's Chicago Pizza
Omega Restaurant (S 27th St)
Popeyes (4209 W Greenfield Ave)
Scotty's Bar & Pizza (Milwaukee)
Portillo’s Hot Dogs (8705 West Sura Lane)
On The Clock Bar and Grill
Famous Dave's - Greenfield
Applebee's (Oak Creek)
Rocky Rococo Pizza & Pasta (Airport)
Thai Barbeque Restaurant
Cafe Zupas - Greenfield
Rocky Rococo Pizza & Pasta (Southridge Mall)
Lakeside Pub and Grill (Milwaukee)
Chubby's Cheesesteaks (Miller Park & Lincoln)
Carrabba's (4765 S 76th Street)
Mario's Italian Grill
Red Robin Gourmet Burgers (7575 Edgerton Ave)
Mad Chicken (S. Milwaukee)
Hardee's (2450 E Layton Ave)
Oakland Gyros (Layton Ave)
Donatos Pizza (7575 Edgerton Ave)
KFC (1570 W. Mitchell)
Mulligans Irish Pub and Grill
Gyro27 Halal (27th st)
Chuck E. Cheese (2701 S. Chase Ave.)
Denny's (4925 S Howell Ave)
Los Comales - Milwaukee, WI
Chili's Grill & Bar (6439 South 27th Street)
Ricanmex Frappes & Grill
Antique Indian Delights
Uber Eats in Oak Creek
Looking for something to eat? Order food for delivery and treat yourself to a scrumptious meal from your favorite Oak Creek places to eat without having to make a visit to S Howell Ave, W Town Square Way, or anywhere in between. With around 50 places to eat in Oak Creek available on Uber Eats, including Indian Delight and Little Cancun, you’ll have your pick of spots from which to order food online. Whether you’re hungry for a snack or planning dinner for a group, order something tasty for delivery online from Oak Creek restaurants near you. Once you place your order, you can track its arrival by the minute.
Oak Creek restaurant delivery and pickup
Once you’ve entered your address, we’ll show you the nearby restaurants offering delivery or pickup. From here, there are a number of ways to find the top takeout options for you in Oak Creek. Another way to discover restaurants near you in Oak Creek is to browse the 10 or so cuisines and categories available, like Chinese. When you already know the type of food or drink you want, browse restaurants by cuisines and categories. If you’d prefer to get your takeout order yourself, check out your options for pickup in Oak Creek, like Crispy and Grill 2 and Cubanitas, for example.
Popular restaurants and food in Oak Creek
It can be tough to choose what to eat when you have so many options. Here are a few favorites among Uber Eats users in Oak Creek. A couple of the most-ordered items among users in Oak Creek are chips & salsa and wild strawberry. To highlight some restaurants that are popular among Uber Eats users in Oak Creek, there’s Macs Macaroni and Cheese Shop for Japanese, Yofresh Yogurt Cafe for Fast Food and Belair Cantina for Mexican. Looking at a restaurant’s rating, which is provided by Uber Eats users, and comparing it to the average restaurant rating in Oak Creek, which is 4.3, can also help you get a sense of its popularity. Try different restaurant choices to find your favorite spots on Uber Eats.
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Frequently asked questions
Is Uber Eats available in Oak Creek?
Where can I find the best food delivery Oak Creek offers?
As you seek out the best restaurants for food delivery and takeout in Oak Creek, consider trying those that have earned a high star rating from users. Enter your address to discover which Oak Creek spots are available near you, then look out for those that have earned 5 stars or close to it.
What’s open now for food delivery in Oak Creek?
Once you enter your address, we’ll show you the places that are open now in Oak Creek, which might include Potbelly Sandwich Works (Oak Creek | 457) or Little Caesars (3109 S Chicago Ave). You’ll also be able to see a business’ hours once you’re on their menu page.
Where can I find cheap food delivery in Oak Creek?
Browse restaurants and shops tagged with one “$” to explore your more affordable options for food delivery and takeout in Oak Creek.
What kind of food delivery can I order in Oak Creek?
Whether you’re in the mood for American Food delivery, Mexican Food delivery, or something else, find something to satisfy your cravings, from the places offering delivery in Oak Creek, like Chick-fil-A (150 W Town Square Way) or Charcoal Grill & Rotisserie (Oak Creek). With takeout options ranging from hearty starters to desserts and beverages, you’re sure to find something delicious to order online in Oak Creek.
Can I schedule an order for food delivery online in Oak Creek?
Uber Eats users can schedule orders for delivery from certain restaurants and shops in Oak Creek. Enter your address to check out the Oak Creek spots offering order scheduling near you.
Can I pick up my takeout order in Oak Creek with Uber Eats?
Some restaurants and stores in Oak Creek allow users to pick up their takeout order. Be sure to toggle to ‘Pickup’ to browse any of those options that exist near you in Oak Creek.
Does Uber Eats offer contact-free delivery in Oak Creek?
Orders can be delivered contact-free in Oak Creek.
How can I get free food delivery in Oak Creek?
To save money on delivery in Oak Creek, join Uber One, as one of the benefits of this membership option is $0 Delivery Fee. Subject to terms, fees and availability. Learn about Uber One here.

domain: food


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lncRNAs with potential to be used as biomarkers, in several types of cancer.
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides in length that, in general, do not appear to have protein-coding potential. lncRNAs act in gene regulation involved with several biological processes. Furthermore, lncRNAs have been associated with a significant number of cancers, suggesting a potential role in tumorigenesis and progression. For example, HOTAIR regulates proliferation processes and other lncRNAs like highly upregulated in liver cancer (HULC), H19, PTENP1, HEIH, and antisense noncoding RNA in the INK4 locus (ANRIL). Other lncRNAs as AFAP1-AS1 and lincRNA-p21 can interact with BCL-2 and TP53, acting in apoptosis. Moreover, NORAD plays a vital role in genomic stability. Additionally, due to deregulated expression and high tissue specificity level, lncRNAs exhibit great potential as prognostic markers. In this chapter, we review the most highlighted lncRNAs acting in hallmarks of cancer and clinical application.
The landscape of human transcriptome is more complicated than was imagined. In the last decade, the technology of RNA sequencing reveals more than 100,000 different RNA molecules produced by mammalian organisms [1, 2], most of them, without protein-coding potential, named as noncoding RNAs (ncRNAs). These molecules called the attention for their multiple roles in cell physiology. NcRNAs are classified, by the size, as small (microRNAs 22~25 bp) or long, with more than 200 nucleotides . Previously, it was considered that lncRNAs were “dark matter” or “transcriptional noise” of the human transcriptome, with no biological functions. Recently, lncRNAs were found in all the branches of the tree of life, and their amount and diversity are more correlated with organismal complexity than protein-coding genes .
The majority of lncRNAs is transcribed by RNA polymerase II, capped and polyadenylated with some lncRNAs being also spliced. They are described as noncoding RNAs. New studies have shown functional micropeptides derived from some of the lncRNAs . Until now, 16,000 lncRNAs were identified in the human genome with approximately 30,000 distinct lncRNA transcripts according to the Encyclopedia of DNA Elements (ENCODE) Project Consortium (GENCODE release 30). This number continues to increase, mainly through sensitive RNA sequencing and advanced bioinformatics pipelines. lncRNAs have a lower expression level than other RNAs, and they show specific expression in tissues [6, 7], cell types, and subcellular compartments . lncRNAs are classified according to their relative position to protein-coding genes in a sense, antisense, bidirectional, intronic, and intergenic . Also, lncRNAs can be regulated by well-established transcription factors and associated with epigenetic signatures that modify chromatin states, making the lncRNA loci more accessible in the cell .
The current knowledge about lncRNAs is essential to understand cell biology, especially in cancer cells. Cancer is a complex disease characterized by extreme genetic and epigenetic changes that can fundamentally alter cell homeostasis to promote uncontrolled cell growth. Emerging evidence suggests that lncRNAs are involved with cancer-associated phenotypes like resisting cell death, invasion, proliferation, gene deregulation, and genomic instability and evade growth suppressors . lncRNAs also interact with transcriptional regulation of tumor suppressors or oncogenes [12, 13]. One example is lincRNA-p21 that acts as a repressor in p53-dependent transcriptional responses . Alternatively, HOTAIR can increase metastasis in primary breast tumors and hepatocellular carcinomas .
lncRNAs can participate in gene regulation at transcriptional and posttranscriptional levels . For example, related to epigenetic mechanisms, lncRNAs can recruit methyltransferases  and polycomb complex  to prevent DNA accessibility through histone modification. lncRNAs are also involved in several posttranscriptional processes, such as splicing and nuclear export, mRNAs localization and stability, and in protein translation process [18, 19, 20, 21, 22].
lncRNAs can serve as a molecular scaffold, enhancing the interactions between protein-protein, protein-RNA, and protein-DNA, by base complementarity or interaction by secondary structures . Alternatively, lncRNAs can function as a decoy when they titrate transcription molecules and other proteins away from the target . Additionally, lncRNAs can work as binding platforms regulating miRNAs competing with mRNAs for miRNA response elements, known as competitive endogenous .
The development of several discoveries about the role of lncRNAs, especially in cancer, highlighted the importance of gene regulation in cellular functions. The evidence that we show here supports the idea that lncRNAs have an essential role in tumorigenesis and are associated with several cellular processes. Here, we review the current knowledge about lncRNAs in hallmarks of cancer and their potential for clinical application.
2. lncRNAs act in hallmarks of cancer
The transformation of a regular cell into cancer involves several processes, including molecular and environmental alterations . The healthy cells must acquire different abilities to change the cell physiology and dictate malignant growth. The hallmarks of cancer comprise the biological capabilities acquired during the multistep development of human tumors. These changes include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion/metastasis . Additionally, genomic instability, inflammation, reprogramming of energy metabolism, and evading immune destruction were also included . There are many lncRNAs well described associated with cancer , and, herein, we highlighted some lncRNAs with strong evidence for cancer process association and with molecular details, for exemple (Figure 1). The influence of those long noncoding RNAs in hallmarks of cancer is due to the regulation of different pathways.
lncRNAs have virtual association in all the hallmarks of cancer, some of them linked with more than one hallmark. For example, the expression of ANRIL, growth arrest-specific transcript 5 (GAS5), urothelial cancer-associated 1 (UCA1), and HULC regulates the resistance to cell death. Also, ANRIL, HULC, and H19 are associated with the evasion of growth suppressors, GAS5, and H19, sustaining cell proliferation. UCA1 and H19 are also associated with invasion and metastasis. Moreover, UCA1 is associated with metabolism reprogramming and GAS5 with an inflammatory process.
In more detail, ANRIL may inhibit apoptosis by silencing KFL2 and p21 genes, involved in cell proliferation. Moreover, regulating MET and MMP3 proteins that facilitate cell migration and invasion [30, 31, 32, 33, 34].
The lncRNA GAS5 can sustain proliferation by regulating glucocorticoid receptors (GR), with strong influences in cell growth and repression of anti-apoptosis genes. lncRNA binds to the DNA-binding domain of GR, competing with glucocorticoid response element .
lncRNA is also observed in cell cycle regulation, whereas it arrests cells in the G0/G1 phase. In stomach cancer, GAS5 binds to YBX1 to regulate p21 expression, enhancing G1 arrest. In bladder cancer, GAS5 associates with CDK6 and reduces both CDK6 mRNA and protein levels, resulting in the inhibition of cell proliferation. Besides, GAS5 acts in the immune response by NF-κB and ERK1/2 pathways. The knockdown of GAS5 increases expression and secretion of interleukin-10 (IL-10) and vascular endothelial growth factor (VEGF-A), the essential cytokines involved in inflammation .
Due to its oncogenic regulatory potential, the lncRNA UCA1 regulates the proliferation and migration targeting the transcription factor KLF832 in pancreatic cancer. UCA1 also promotes invasion and metastasis through activation of MMP14, FGFR1/ERK, and ZEB1/2-FSCN1 [37, 38, 39, 40]. In hypoxic conditions, HIF-1α effectively activates UCA1 transcription by binding in the UCA1 promoter, inducing proliferation, migration, invasion, and apoptosis resistance of cancer cells .
Several pathways regulate the switch of oxidative phosphorylation to aerobic glycolysis, such as the PI3K, AMPK, p53, and HIF-1 pathways. These pathways are involved in metabolism deregulation associated with the Warburg effect, which consists in the special metabolism of glucose in the cytosol even in the presence of oxygen [42, 43], and UCA1 acts indirectly in genes involved in this process [44, 45].
HULC contributes to malignant phenotypes by, at least, three mechanisms. The first is regulating the expression of P18, an auxiliary protein of cell cycle that inhibits the tumor suppressors CDK4 and CDK6. Also, hepatitis B virus infection activates the HULC promoter and induces cell cycle progression by downregulation of P18 . The other two mechanisms are related to angiogenesis. In breast and liver cancer, HULC sequesters miR-107 and regulates the transcription factor E2F1/SPHK1 [47, 48]. In glioma, HULC acts through PI3K/Akt/mTOR signaling pathway, inducing ESM-1/VEGF-A and affecting vascular permeability and cell mobilization .
Some lncRNAs have been described more exclusively in only one hallmark, for example, telomeric repeat-containing RNA (TERRA) associated with replicative immortality. We know that cells have a limited survival rate that can be explained by telomere end loss, which generate a waste of genetic conservation, restricting the number of mitosis in a tissue. Thus, neoplastic cells can escape this telomere process with the help of telomerase. This enzyme can increase the size of telomere adding repeats on the edge 3′ in chromosomes . TERRA comprises a heterogeneous class of lncRNAs transcribed from telomeric regions . TERRA transcripts negatively regulate the activity of telomerase, acting as a tumor suppressor. Besides acting as telomere maintenance and genome stability, TERRA is also regulated by genes, such as TP53 and RB, highlighting that TERRA transcripts can be crucially involved in tumorigenesis [52, 53, 54].
Another critical feature of neoplastic cells is in genomic instability, which can be related to defects in the DNA repair machinery. Activation of telomerase, following by individual DNA variations, activating proto-oncogenes or deactivating tumor suppressor genes, conferring a selective advantage on subclones of tumor cells, enabling their survival and outgrowth .
One lncRNA that is important in this tumor cell feature is NORAD. lncRNA protects the cells against aneuploidy by binding to PUM1/PUM2 proteins and suppressing their binding to other targets, including those that maintain genomic stability [55, 56]. An alternative mechanism to define the relationship among NORAD and genomic stability is that a nuclear ribonucleoprotein complex, named NORAD-activated ribonucleoprotein complex 1 (NARC1), is joined by NORAD, recruiting proteins known to act as suppressors of genomic instability, such as topoisomerase I (TOP1), ALYREF, and the PRPF19-CDC5L .
The implication of lncRNAs in cancer development and progression has been proved in the last decade and indicates that those new class of RNAs has a great potential as biomarkers on cancer and a future perspective to targeted specific therapies.
3. Clinical application for lncRNAs
As we discussed in earlier topics, we have examples of lncRNAs that participate in essential processes in tumor development. Many of them have great potential as diagnostic/prognostic markers and therapeutic targets. A great example is the lncRNA prostate cancer antigen 3 (PCA3), already used as a molecular marker in prostate cancer [58, 59]. PCA3 is a prostate-specific lncRNA overexpressed in 95% of prostate cancer cases. PCA3 may be detected by in vitro nucleic acid amplification in urine specimens, and the US Food and Drug Administration approved the test in 2012 .
In cases of suspicion of prostate cancer, the PCA3 test is recommended, based on prostate-specific antigen (PSA) level and post-digital rectal examination with biopsy results. PCA3 has a high expression in prostate cancer without any correlation to prostatic volume and other prostatic diseases. This feature makes a PCA3 an attractive biomarker , but some recent studies question the use of this isolated biomarker and propose that the test should be carried out in association with another test, like TMPRSS2:ERG quantification .
Although there are few lncRNAs used in medical practice, many are being discovered and tested. For example, a treatment protocol for triple-negative high-risk breast cancer predicted by the integrated mRNA-lncRNA signatures is initiated in the clinical trials evaluated, to validate the efficacy of lncRNA signature .
Also, in clinical trials, there is an early phase study to evaluate the HOTAIR as a potential lncRNA biomarker in thyroid cancer. Many lncRNAs have a different expression in tumors when compared to healthy tissues and are strongly associated with clinical parameters, making them a candidate for tumor markers or even therapeutic targets .
A study found the downregulation of expression of downregulated in liver cancer (DILC) in colorectal cancer tissues compared to their adjacent healthy tissues and the normal colorectal tissues. The downregulation of DILC was associated with aggressive clinical characteristics, including depth of invasion and advanced TNM stage, and the lower expression of DILC was associated with more reduced survival and disease-free survival. With multivariate analyses, the authors confirmed that the expression of DILC was an independent prognostic factor in colorectal cancer . Most of lncRNA papers characterize biomarkers that are specific to one type of cancer, such as those cited above. However, some lncRNAs are found differentially expressed in several types of cancer compared with healthy tissues, like the loc285194 lncRNA .
In addition to the association of lncRNAs with stage and prognosis, their association with drug resistance is also possible . Several works have tried to reallocate the lncRNAs in the mechanism of resistance to the primary drugs used in the treatment of cancer. For example, Campos-Parra et al.  have identified several lncRNAs that participate in resistance mechanisms to several drugs utilized in the therapy of breast cancer. Most studies with lncRNAs measure their expression in tissues, but it is possible to detect and quantify their presence in other types of samples, like whole blood, plasma, urine, gastric acid, and saliva .
Within the use of lncRNAs as biomarkers in cancer, these molecules have applications as therapeutic targets in the development of new treatments and drugs. New therapeutic strategies are already focusing on noncoding RNAs, such as silencing via small interfering RNA (siRNA), an antisense oligonucleotide (ASO)-based strategies and other molecular inhibitors further modulating lncRNA expression by gene editing [69, 70]. An experimental model that aims to modulate lncRNAs in cancer cells is the use of siRNAs, which can decrease the amount of a target lncRNA, since they are complementary molecules to the sequence of lncRNA, promoting lncRNA binding and subsequent degradation. Although this methodology may be functional in many studies, some lncRNAs are not efficiently reduced by siRNA . This methodology is efficient for cytoplasmic lncRNAs since the siRNA mechanism is located predominantly in the cytoplasm. In this case, siRNA does not silence nuclear lncRNAs [11, 71].
Another mechanism used to block lncRNAs activity relies on the ability of lncRNAs to bend and create secondary structures and on the ability of protein interactions in lncRNAs. RNAi molecule can compete with the protein for the binding site; or when it binds to the target lncRNA, it changes the structure of the RNA, disrupting the binding site of the protein [72, 73].
For nuclear lncRNAs, an alternative strategy is the use of antisense oligonucleotides, which function predominantly in the nucleus . ASOs modulate gene expression by inducing ribonuclease H cleavage of the duplex DNA-RNA. A limitation of the ASO and siRNA strategies is the possibility of non-specific targets, as well as the inconvenience of incomplete knockdown and transient modulation . One method that has shed light on ncRNA-based cancer therapy and solves the problem of target specificity is genome editing by clustered regularly interspaced short palindromic repeats-associated endonuclease 9 (CRISPR/Cas9). The Cas9 nuclease can act guided to generate site-specific DNA cleavage in the genome, by an optimized equivalent single-guide RNA (sgRNA) . That is, it can delete lncRNA genes or introduce RNA-destabilizing elements into their locus.
A limitation to apply CRISPR/Cas9 system to noncoding genes is that tiny indels may not necessarily generate a functional loss of a specific noncoding gene and the most protocols can perform small point mutations; plus not all lncRNAs CRISPR can be applied. Another limitation is that, although it is more specific than other systems, this technique may still have off-target effects [76, 77].
Currently, many studies performed lncRNA modulation technologies, both in vitro and in vivo. Moreover, while these models may resemble reality, the clinical use of modulation technology has a barrier that still needs to be broken: an efficient delivery to the target. There are some techniques for delivering lncRNA modulation systems to live cells, based on viral and non-viral methods, but both ways have limitations and problems to be solved before the utilization in clinical practice.
The main advantage of viral vectors is their innate ability to efficiently transfer the genetic material into the cell and the possibility of infecting specific cells. However, this technique also has a significant disadvantage, which is relatively high immunogenicity and toxicity. The possibility of generating an immune response is the main challenge for the use of this tool [78, 79].
Non-viral vectors are becoming recognized as an alternative to the immunogenicity of viral vectors, although their transfection capabilities usually do not reach such levels. Besides its main strengths are the low capacity to generate an immune response and the relatively easy and inexpensive synthesis with large-scale production and safety, which make them very attractive delivery systems for in vivo application. However, the target specification still needs to be better developed .
In order to choose the best delivery system, it is necessary to consider the type of cell/tissue, since some tissues are more accessible than others. When the target of therapy is a difficult-to-access tissue, some strategies may improve delivery efficiencies, such as binding to specific targeting elements like antibodies, carbohydrates, and synthetic peptides. These molecules also have their advantages and limitations; for example, although antibodies have a high recognition specificity and interaction with different receptors on target cells, they may be immunogenic and chemically unstable. Peptides and carbohydrates, on the other hand, demonstrate low immunogenicity, but the binding affinity to the target is lower [79, 80].
All the techniques cited in this topic have their limitations. Althoughin vitro studies present satisfactory results that have the potential to use in clinical aspects. However, these techniques require better improvements, especially in the delivery of drugs in specific targets. Despite this, our knowledge of lncRNAs linked with clinical applications creates hope for the development of better biomarkers and therapeutic targets. In Table 1, we list the main lncRNAs that have excellent potential for biomarker and therapeutic target.
The vast number of studies describing lncRNAs associated with several tumor types and regulating several processes of cancer cells is shown here. The great advance in RNA sequencing technology allows us to identify new molecules and characterized better lncRNAs. From the discovery of these molecules, in the beginning, they appeared to have no important functions; however, today many researches in this area propose that more information about these molecules may help us understand numerous characters of tumor cells that are still unknown. Some lncRNAs are associated with several hallmarks of cancer demonstrating the importance of these molecules in the mechanism of disease, like MALAT and HOTAIR. Other are already utilized as biomarker in prostate cancer like PCA3. Considering the challenges for in vivo experimental designs, lncRNAs continue to be promising as biomarkers and potential therapeutic targets.
Conflict of interest
The authors declare no conflict of interest.

domain: biology


text:
- Dimples Romana has taken to social media to post about the messages she received from netizens after the Miss Universe Philippines 2021 pageant
- She said that she has been tagging and telling her about having resemblance with MUP 2020 Rabiya Mateo’s look during the coronation night
- The actress likewise posted a screengrab of Rabiya passing on the crown to Beatrice Luigi Gomez of Cebu City
- Aside from reacting to the hilarious messages, Dimples also congratulated Beatrice and people who are part of the pageant
Like and share our Facebook posts to support the KAMI team! Share your thoughts in the comments. We love reading them!
Dimples Romana recently reacted to hilarious messages she received from netizens following the Miss Universe Philippines 2021 pageant.
KAMI learned that in an Instagram post, the actress said that netizens have been tagging and messaging her about having resemblance with Rabiya Mateo’s look during the coronation night.
“Putting this here because my social media notifications on ALL PLATFORMS ha, were overflowing with your messages and tags na Bakit ko daw ipinasa ang corona ako daw ang Mondragon,” she shared.
“Si queen @rabiyamateo po yan. Hindi ko kayo kayaaaaa LOVE YOU Netizenssss!!!”
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Dimples then went on to congratulate Miss Universe 2021 Beatrice Luigi Gomez and people who are part of the pageant’s successful coronation event.
Read the actress' full post below:
Dimples Romana is a veteran Filipina actress who gained more prominence because of her performance in “Kadenang Ginto.” She was acclaimed for portraying the character of Daniela Mondragon, which has become an iconic villain in the country.
She is one of the inspiring actresses who spend their showbiz earnings wisely. She once again wowed her followers after sharing about her first restaurant abroad. Her newly opened restaurant is called Alegria Singapore located at Teck Lim Road in Singapore. The actress took to social media to share some glimpses of her new business.
Dimples also could not help but get emotional as her friends Angel Locsin and Neil Arce tied the knot. The actress likewise posted a photo where she could be seen crying while witnessing the couple’s wedding. It can be recalled that the celebrity couple made headlines after announcing about their civil wedding.

domain: entertainment


ALL-NEW MAZDA MX-5 ICON SPECIAL EDITION TO DEBUT AT THE 2016 GOODWOOD FESTIVAL OF SPEED
◾On sale from the 1st August, the £20,995 on-the-road Icon special edition is limited to just 600 cars.
◾First special edition version of the 1.5-litre 131ps all-new Mazda MX-5.
◾Joins a host of other MX-5 highlights at the 2016 Goodwood Festival of Speed.
The all-new Mazda MX-5 Icon special edition will make its public debut at the Goodwood Festival of Speed. Joining Mazda's award-winning sports car line up from the 1st August, the Icon is based on the 131ps SE-L Nav and is the first special edition fourth-generation MX-5 wîth the 1.5-litre SKYACTIV-G engine.
With a choice of free-of-charge Meteor Grey Mica or Crystal White Pearlescent paint, the £20,995 on-the-road Icon is marked out by its contrasting design cues and enhanced standard equipment. Visually the Icon makes a bold statement wîth its Soul Red Metallic wing mirrors, rear spoiler, side stripe decals (not pictured) and front skirt. The unique look is further boosted by 16-inch Gunmetal alloy wheels, while the increased equipment tally also includes black leather seats, rear parking sensors, dusk-sensing lights and rain-sensing wipers.
On display at Goodwood within Mazda's unique 'Raise the Roof' live music area, the Icon joins a host of other MX-5 highlights at this year's Festival of Speed. These include the European debut of the all-new Mazda MX-5 RF, plus the first appearance outside of North America for the MX-5 Speedster and Spyder concept cars. While marking the amazing popularity of the world's best-selling two-seater sports car, the one-millionth production MX-5 will also be on display.
The fourth car to wear the Icon badge - previous MX-5 Icon special editions were sold in the ÚK in 2000, 2005 and 2007 (see below) – the latest Icon is a striking sports car wîth an achievable price, and limited to just 600 cars it's available to order now.
Pre-order is also open on the all-new Mazda MX-5 RF ahead of its arrival in dealerships next year, and wîth limited supply in the opening months, fans of the latest incarnation of MX-5 should register their interest now to be one of the lucky few to take delivery of early versions of the Retractable Fastback, a car that represents the next chapter in the MX-5 success story.
'We are delighted that ÚK MX-5 fans will get to see both the Icon special edition and the all-new Mazda MX-5 RF at the Goodwood Festival of Speed', commented Jeremy Thomson, Managing Director of Mazda Motors ÚK. Adding, 'with over 120,000 sales since its launch in 1990, the ÚK has played a huge part in the MX-5 success story and the Icon follows a long tradition of special edition MX-5s that allow customers to have a stand out vehicle which is truly affordable. And I'm really excited about the all-new Mazda MX-5 RF, this is a car that offers something new and I'm sure it will attract even more people to the MX-5 family, which is why I'd encourage anyone interest in the RF to pre-order early, as based on dealer feedback after its launch at the New York Motor Show, we envisage that demand will outstrip supply when the car goes on sale next year.'
With the Moving Motor Show on the 23rd June, the 2016 Goodwood Festival of Speed takes place from the 24th to the 26th June.Mazda MX-5 Icon special editions
2000 MX-5 Icon
Number built: 750
Colour: Art Vin Red Mica2005 MX-5 Icon
Number built: 1,563
Engine: 1.6i and 1.8i
Colours: Chilli Orange, Black Mica, Sunlight Silver and Titanium Grey2007 MX-5 Icon
Number built: 1,250
Engines: 1.8i and 2.0i
Colours: Copper Red, Stormy Blue and Marbie WhiteSource - Mazda
Rumor to be designed after the Lotus Elan, the Mazda Miata is the world's best selling sports car. With over 720,000 produced between 1989 and 2005, production proves Mazda held its title consistently.
The history of the Miata is one of interest and success. Unveiled in 1989 as the 'Eunos Roadser', prior to the name change to the Miata, it was a designed collaboration between the USA and England. Created to be a basic roadster without unnecessary weight, it was an instant success with over 23,000 sold by the end of its first year. With a starting price of $13,800, the Miata, despite its small design, made a sizeable impact in the success of Mazda's future.
The shell of the Miata is all steel with an aluminum bonnet. Weighing in at over 2,380 pounds, the Miata confirmed its small roadster appeal. The trusswork is uniquely called the 'Powerplant Frame', which connects the engine to the differential, creating a more firm and responsive feel. It's quick and responsive handling is helped due to independent double wishbone suspension on all four wheels with an anti-roll bar at the front. Optional paddle shifting was available with the six speed automatic versions of the Touring, Sport, and Grand Touring models. With power to the rear wheels, drivers thirst for corners even if they're beginners.
The Miata's appearance ranks among attractive qualities. Its cozy, subtle, curved design helped to propel sales to customers of all ages to a higher level. The bright color palette offered during production accented the appearance and still turns heads today, making onlookers yearn to get behind the wheel of this convertible on owners pine for the summer months.
A 'Special Touring Option Edition' was also offered, which included stainless steel scuff plates, Twilight Blue paint, and 15 inch Enkei wheels. The 'Club Spec' version was available with 16 inch alloy wheels and four wheel disc brakes with ABS, but also offered a limited amount of color options: Winning Blue Metallic, Marble White, and True Red.
The interior, though tight, beckoned stereo enthusiasts and those who revel in the appeal and stigma of leather. Optional passenger-side airbags and standard drivers–side airbags provided safety without drastically impacting the beauty of the interior.
With the introduction of the 'M Edition' came a wood shift knob and chrome wheels with Montego Blue paint. The option of a wooden parking brake handle was available on this edition for complete look. Other editions such as the 'Touring Package' included power steering, a leather wrapped steering wheel, power mirrors, aluminum alloy wheels, and power windows. Also, the available 'Club Spec' model included CD player with speed sensitive sound, four speakers, black cloth trimmed upholstery, power windows, locks, and mirrors and black vinyl top.
Engines for the Miata were available with a 1.6L, 1.8L or 2.0L. The 1.6 L dual overhead cam inline four-cylinder engine produced 120 horsepower with 0-60 times consisting of 8.2 seconds and a top speed of 119 miles per hour.
The 1.8L produced 140 horsepower with help of the raised engine compression ratio and the additions of domed pistons. The additions also helped the 0-60 time, which was marked at 7.9 seconds with a top speed of 123 miles per hour. In 2005, the 2.0L was the latest engine thrusting the Miata. The 16 valve engine produced 170 horsepower with a 0-60 time of 6.5 seconds, bringing the Miata to a fast finish when production ceased in the same year.
Even though all 3rd generation 2006 models all over the world now go with the name 'MX-5', the Miata will always be the true coupe that helped to accelerate the sports car appeal with today's roadsters.Kyle McMullen


My fiancé and I are members of the Sepulveda Community Garden Center in Encino where we have two plots. Our first plot (in the photo below) is 30 x 20ft, and our newer plot is just under 10 x 20ft of space.
In this larger plot we had two lettuce plants that bolted, which means they started blooming flowers and going toward forming seeds.
On our last garden visit, we pulled the plant and cut the tops with the seeding flowers off. We then recorded the seed harvesting progress in the video below. Enjoy!


Manyetoreolojik (Mr) Sönümlendiricili Diz Eklemi Tasarımı ve Analizi
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In this thesis, an electronically controlled, semi-active, above-knee prosthesis, which can adapt to environmental conditions, has been designed to restore natural mobility to people who have lost their legs above the knee. The prosthesis designed in this study contains magnetorheological damper as an actuator. Due to its short response time, this damper, which can be controlled by a current, is found suitable for continuous time control. The damping control of the torque produced during the gait from the user's hip provides a movement close to the natural knee motion. The first condition for successful control is to obtain the theoretical models of the gait and damper dynamic behaviour. Then the performance analysis of measurement phase are carried out by utilizing the obtained models and control block into the simulation environment. Kinematic and kinetic behavior were examined separately during the derivation of theoretical model. For the kinematic analysis of the gait, a leg and foot were regarded as a robot manipulator with three revolute joints and three prismatic joints. Forward and inverse kinematics, velocity kinematics and trajectory generation topics were discussed on the manipulator frame. The kinetic behavior is determined by the analysis of dynamic equations derived from the relationship of the leg and foot with the ground plane during walking. Differential equations establish a link between the kinematic (displacement, velocity and acceleration) and dynamic (forces and torques) variables of gait. The performances of analytical models were examined in a simulation environment by using kinetic and kinematic measurements obtained from natural gait trials. The theoretical model obtained from the priori stage was evaluated in the simulation environment considering the input-output relations and the control of desired gait scenarious. Theoretical models, validated using real gait measurements, are examined in the closed loop control structure and the results are observed. This part provides the analysis giving an idea about which extent the differential equations can express prosthetic gait and their controllability. Given results presented that stance phase errors introduced by the double pendulum can be corrected by the inverse double pendulum model. Therefore, an important improvement has been presented by proposing inverse pendulum model to the control problems when both swing and stance phases of the gait were used in the unified model. In the control stage carried out on the embedded system, control parameters obtained from the simulation environment via the continuous-time control algorithm that adjusts the current driving the damper, and a variable torque are generated for the knee joint according to the measured and estimated kinematic variables. Based on the difference between the measured knee angle and the reference knee angle, the controller adjusts the stiffness level of the damper in real time. One of the most important expectations of the application is to give a proper reference knee angle according to the gait phases. Based on this purpose, knee angle was estimated by using inertial sensors attached onto the prostesis. Under the light of the results of experiments and analyzes conducted, the suitability of the magnetorheological damper for continuous time control has been verified and the results are reported.


text:
This post is over a year old but I just found it.
Here's an excerpt:
To those not acquainted with New Orleans:
Yes, we realize that much of our city was built below sea level. It's kind of the first thing you learn in school. Right after that bit about that George guy and the cherry tree and right before eating paste is bad for you.
Yes, we realize our geography leaves us more vulnerable to flooding. We don't know this because we are smart. We know this because it rains a lot and we get off of school.
Yes, we tried to protect ourselves from it.
Yes, it has worked in the past with varying degrees of success.
No, it did not work this time.

domain: geography


text:
The Nick Hall thriller series by Douglas E. Richards is a winner! But how do I describe this intense page-turner without giving away too much? I can say that Richards has created a likeable and resilient protagonist who finds his world tipped upside down and turned inside out. Nick Hall has been through hell and continues to face earthly devils who would destroy him without breaking a sweat. Nick stumbles his way into relationships with a resourceful woman, the head of a military PsyOps division, and computer geeks. As he runs for his life, you will be urging him onward, hoping that somehow he’ll stay sane and survive.
Richards has done his homework- and more- on technology, love on the run, and supervillians. Of course, with his background in microbiology and genetic engineering (with mutant viruses named after him), Richards knows what he is about. The premise underlying “Mind’s Eye” is quite unusual but compelling. I never had to suspend disbelief because the characters themselves struggle to believe what’s happening. As Nick and Megan wind through this labyrinth of suspense, they ask and answer all my questions. If you love thrillers, if you want to witness a battle with humanity’s destiny at stake, “Mind’s Eye” will satisfy!
To my nephew, Isaac, homework is “tor-tradition,” meaning torture + tradition. See? He has some math sense and lots of common sense. Poor Isaac. As third grade has shifted into hypermode to prepare for the end of grade tests, he has been left dangling. There’s not enough time for remediation after school, not with the tor-traditional piles of homework. Fortunately, he has a flexible teacher who is now willing to let him move through the multiplication.com system of learning his times tables. After months of trying more traditional (and yes, torturous approaches), I switched to Alan Walker‘s language- and association-based approach. It has paid off bigtime for Isaac, providing him with a dose of much-needed confidence. But is it too little and too late?
Isaac would benefit from a formal educational and psychological evaluation. He appears to have serious weaknesses in auditory processing skills, along with attention, working memory, and long term memory issues. His success in reading fluency camouflages many of his weaknesses. Sometimes both teachers, parents, and kids think everything is fine if you can read above grade level. Ouch. Try giving Isaac multistep directions and watch the confusion. And like many twice exceptional kids, Isaac’s mental energy has been fried to a crisp after half a day of school. His teachers report that he spends his afternoons in silence, never responding and apparently inattentive. At home, he screams and bangs his head when it’s time for homework. Torture indeed.
I don’t think it’s too late for this sweet kiddo. He is eager to learn, responds well to instruction in incremental steps, and has enough curiosity for an entire classroom. And he can do a perfect Patrick or Spongebob imitation. Isaac can go far, especially if a certain tortuous traditions can be axed.
Whew! After our city had declared a state of emergency due to a fluoride issue-water main break, we are now back to taking showers and flushing toilets. How much we take water for granted! I had to tape off the faucets because I automatically reached for one all the time. Who knew I washed my hands so much? What an adventure we had Friday evening with about 25 folks in our home group, sharing toilet tanks that had to be filled by hand. We resurrected Jerry Brown’s poem (governor of California during a serious water rationing period): Yellow is mellow, brown goes down.
The water crisis was a relatively brief and local one, but tens of thousands of us descended on nearby counties in a desperate hunt for bottled water. As I waited in line with my own cart packed to the gills with food AND water, I asked a guy in the next line if I could take a photo of what we were all doing: emptying Durham County of its bottled water.
We are blessed and spoiled with our clean running water. And our electricity and abundance of grocery stores. And the money to shop. And the freedom to worship. Our entitlement goes deep. I read angry Tweets about living like a third world country. Oh, the very idea! Seriously, I have no idea how wretched that would be. I’m just glad that we had working toilets when the kiddos arrived last night and running water for our Super Bowl event (pun intended).
Now enjoying our blessings and trying to figure out how to store gallons of water….
You must check out the Bluebird‘s post for the cleverest connections of cat photos to literature. My faves are “Macbeth” and “Little Women.” Teachers could use this idea to spark interest, compare-and-contrast, and book conversations! The one below is “Bambi,” of course.
via Happy Caturday — literary edition — bluebird of bitterness
I love Nerd in the Brain‘s weekly blogging challenge to add thankfulness to my blog. This week has been a challenge but there’ve been some great points, too.
Number One: Fire in the Hole! I did not set fire to a student, myself, or the classroom when we did experiments on the element carbon. Yes, it was close, but no cigar!
Number Two: How old are you …? Birthday cakes are just an excuse to play with matches, especially when the kiddo has double digit candles. Whee!
Number Three: Tooth Fairy Time. At my age, I don’t want to be losing teeth, but how adorable when it’s your baby teeth! This sweetie is losing the other top front tooth now, so I wonder how she will eat and speak! Somehow we all survived this. And some of us got rich in the process.
Greenglass House is a children’s mystery, probably enjoyed most by upper elementary kids and middle schoolers. Written by Kate Milford, this book goes far beyond the realm of mysteries and suspense in its development of characters and heartfelt emotion. The story takes place during Christmas break at an ancient but gorgeous “smuggler’s” inn, occupied and operated by the Pine family. Greenglass House is as much a character as the people, with its huge, mysterious stained glass windows and shady past. Milo Pine, a 12 year old, is looking forward to a quiet vacation with his parents when when an odd assortment of individuals arrive unexpectedly at their inn. Milo’s world is tipped upside down when he meets Meddy, a stranger who initiates a roleplaying “campaign” to learn more about these peculiar guests. Milo and Meddy are both strong-willed individuals who couldn’t be less alike. Their interactions are priceless.
Milford is a master of layering themes and creating complex events which force characters to confront their motivations and fears. For instance, we learn that Milo struggles with issues related to his adoption and the reaction of others to his appearance (he’s of Asian descent with white parents), torn between loyalty to his loving parents and a desire to know more about his biological family.
Milo and Meddy have no idea what their campaign will uncover and believe me, you will be shocked. But the tenderness and healing, along with wild and wooly events, will keep you riveted to this book. A word of caution: If you are reading this aloud, be prepared to cry in front of your kiddos. The ending is truly amazing.
I just finished reading the third of Kerry Wilkinson‘s Jessica Daniel series and can’t wait for the fourth (and final- for now). Wilkinson, a British author, has written real winners with this series. The Killer Inside is a clever thriller with believable characters and no need to suspend disbelief. Jessica Daniel is a detective who just won’t give up; she is passionate about justice and has such a clever mind. Wilkinson has created a strong young woman with a fairly normal past and present. She faces many challenges in The Killer Inside, including apparent random serial murders occurring in locked homes, along with other professional and personal issues. I couldn’t stop reading and was thrilled to discover the rest of the series. Plus, I identify with her approach to paperwork: falling stacks of paper but she knows where everything is. Read this book and you’ll be hooked!
No, I did not make this chess cake, but it was delicious! Not at all bittersweet in taste. Thanks, Jennifer Nichole Wells, for your Color Your World challenge.
… is yummy! Gotta love the color beaver. And this fudge is good for you- naturally sweetened, organic cocoa, and everything. This is my post for Jennifer Nichole Wells’ Color Your World challenge.
After our recent snow event, a lot of us headed to car washes to remove brine and grime. I sat in my car, enjoying the view and relaxing after a long day. Yeah, my life is full of adventure. Here is my entry for black in Jennifer Nichole Wells’ Color My World challenge.

domain: literature


text:
NYC’s Dance Music Comedy Art Show: Feb. 8 at 10:30pm
Since 2013, Ten-Foot Rat Cabaret presents an inspired, curated monthly celebration of amazing dance, gorgeous music, smart comedy, clever storytelling, hot burlesque, art and theatrical vaudeville spectacle. A great show in a legendary East Village venue: A campy, classic NYC nightlife experience like no other!
(Great reviews and Ticket info at bottom)
Saturday February 8, 10:30pm Show Features –
Bossa nova, samba, choro: those lovely soulful yet light sounds that make everyone slow down and sway. Thalys Peterson is a Brazilian Classical guitarist with a mastery and a delight. Ah, Brasil…
– (Listen to Thalys)
MOE & MARY:
Favorites of Fringe and Frigid theater fests around the world, Mary Crosbie and Moe Rosen are the Canadian husband-and-wife team called a “Dark postmodern Burns and Allen”: Hilarious, silly, horrifying and loveable, this vaudevillian duo will make you suspect a tesseract opened up to the Golden age of Radio – until you start listening to their insane and insanely funny “conversations.”
Violence, love, drugs, creation, destruction and the human race’s destiny: Leesa Liquidsteel, a founder of the Romulus and Good Bison dance ensembles, performance artist, and storyteller, returns from Austin to NYC with her blend of lights, sounds and visceral physical art.
Classically trained in opera (dig those high notes!) and veteran musical-theater pro, Melissa Grace is a troupe member of Guilty Pleasures Cabaret, You’ve seen her steal the show in “Sway With Me” at The Triad (Upper West Side, Manhattan) and “Speakeasy Social” at 54 Below (Off-Broadway). Now catch her beautiful golden pipes at the Rat!
‘GERMAN ARISTOCRAT’ … OR CON MAN?
Valentine’s lies! Is he “Germany’s Most Popular Comedian” … or escaped criminal? Continental kitsch and dark humor with Gregory Levine as aristocratic criminal Gregor of Berlin. Suave, sinister, witty and sarcastic, Herr Gregor regales the audience with horrid tales of warped Teutonic childhood, decadence, and of course, show biz. Gregory has been seen on the Travel Channel, at 54 Below, and at the Capital Fringe and NY Frigid Theater Festival, The Duplex, the PIT Comedy Theater and Guinness Book of World Records. He also hosts the weekly Electric Stage Open Mic performing-arts showcase.
VIDEO BY BILL:
The Rat would not be complete without our Artist-in-Residence: the funny, brilliant, and bizarre Bill Chambers. He brought us Henry Rollins’ Children’s Book Read-a-long, David Lee Roth’s Therapy Session, Vincenzo the Chain-Smoking Monkey, Neil Diamond’s True Crime Confessions. Expect the unexpected from this hilarious performance-art polymath… now raising a baby! (Among his accolades: 2019 Gotham Storytelling Festival; Opening the Nov. 2018 Gotham Storytelling Festiva; and slaying at the NY Times Critic’s Pick Sideshow Goshko.)
Stand Up Comic/Storyteller, Canadian Import Jillian Thomas (MTV Live, The Buzz, The Toronto Show, Listen Missy and Much Music’s Love Court). Not to mention the annual East Village Oscar Awards Party, and Canada’s longest-running cannabis-cafe comedy-club show!
Produced by Rob Dub and Gregory Levine
~Beer, Wine, Japanese Sake and Hard Cider Sold in Theater~
(Age 17+ or accompanied by guardian to attend show / 21+ with ID to Drink)
WHERE and WHEN:
Ten-Foot Rat Cabaret
at Under St. Marks Theater
94 St. Marks Pl. (8th St.) bet. 1st Ave. and Ave. A
Saturday, Feb. 8, 2020 – 10:30pm
TICKETS – Reserve Online or buy at the Door. See Terms of Sale.**
Read the Reviews:
“The Ten Foot Rat Cabaret impressed me again with a solid line-up of talented performers!” – Chris Struck, NYC Theater Blogger
“Great example of what a variety show can be!” – Opplaud.com
“Very fun stuff. That’s what you can expect from Ten-Foot Rat Cabaret.” – ApplauseApplause
Special Thanks to Frigid NY/Horse Trade Theater Group
** Terms of Sale:
All sales final.
Seating is by general-admission basis.
Ticketholders seated first in case of sellout.
Unclaimed Reserved tickets become available to Standby Purchase line once show has begun.

domain: artistic


Sleeping on a mattress that is not comfy can be frustrating since you hardly get to rest at all. Furthermore, everyone recognizes that sleeping on a brand-new mattress is amazing compared to purchasing one. If you are considering whether or not to buy a new mattress, this overview will certainly help you find the best top quality. Best Mattress For Sale
Here are different steps that you require to follow when selecting the most effective mattress on the market. Moreover, there are likewise different variables that you might wish to take into consideration when shopping for such an item.Best Mattress For Sale
Types Of Mattresses Available In The Market
When it comes to picking a mattress, you need to comprehend that people do not have the same sleeping preferences. That is why there are various choices available in stores. This makes it challenging for clients to choose which mattress to select. However, with the help of our overview, you can be sure to find a comfy mattress to make sure that you can take pleasure in a restful sleep.Best Mattress For Sale
Common Sorts Of Mattresses.
1. Memory Foam
These particular mattresses are understood for their eliminating residential property as a result of high pressure. Memory foam mattresses also contours the shape of your body when sleeping. Nonetheless, the only drawback with this kind of mattresses is that they are not suitable for everybody, particularly hot sleepers. But, there are memory foam mattresses that are more advanced and designed with distinct cooling features.Best Mattress For Sale
Are you curious about a mattress that has both convenience as well as perfect bounce? If your solution is yes, after that you could intend to think about getting this sort of mattress that is made from latex. These mattresses are known to help with restful rest due to their amazing cooling homes.
This is one of the most typical kind of mattress. Coils mattresses are made with an innerspring, which may be one or several layers. This innerspring plays the role of providing maximum convenience and also assistance. You also need to be familiar with the reality that the sorts of coil, number, as well as layers used are most likely to change if someone’s choice adjustments.Best Mattress For Sale
Pillow-top mattresses often fall under different classifications such as latex, hybrid, and also coil. What you require to know about this sort of mattresses is that they are developed with an added layer of soft product that is stuffed or stitched inside. This supplies a soft cushioning for the person resting.Best Mattress For Sale
This type of mattresses are considered to be advanced. That is since they can only be manufactured by incorporating memory foam, latex, as well as coils. Due to this reason, hybrids mattresses have actually confirmed to be the very best.
You can purchase this kind of mattress if you intend to experience unmatched bounce. It likewise helps eliminate stress even when slept on for an extensive period.
Establishing The Best Sleeping Position Along With The Suppleness Of A Mattress
Individuals oversleep different sleeping placements. There are those who such as sleeping on their back, while others like sleeping on their tummy. Whichever, your ideal sleeping placement is, we will assist you locate what you are looking for! Below is a guide on exactly how to establish whether a mattress is firm enough to support your excellent resting placementBest Mattress For Sale
If you are the sort of person who likes sleeping on his back, then you need a mattress that is firm sufficient to support this section. Besides having the required firmness and also support, it needs to additionally be soft. You can prevent neck and back pain by sleeping on a mattress that has a suppleness variety of between 5-7
The very best mattress for an individual that sleeps on his or her back is the memory foam mattress. That is since it contours to the sleeper’s body and supplies optimum comfort.
When you sleep on your belly, all the stress is directed to the torso. As a result of this factor, look for medium-firm mattress. Furthermore, make sure that the mattress you pick is not too soft because it will certainly create your spine to contour and also lead to back pain.Best Mattress For Sale
Lots of people that favor sleeping in this setting struggle with pain as well as discomfort influencing the shoulders as well as hip joints. Nonetheless, such resting issues can be gotten rid of by acquiring a mattress that is a bit soft.
Various Other Trick Aspects To Consider When Shopping For A Mattress.
Below are other crucial variables you might want to think about when shopping for a mattress.
Mattresses are created with multiples layers. Each layer is full of various materials in order to supply support when sleeping. Additionally, you likewise require to recognize that the degree of comfort on a mattress is figured out by the positioning of these layers.
One more vital aspect to consider when selecting a mattress is weight. Cumbersome mattresses may seem hefty however they are much more comfy. Besides being comfortable, heavy mattress are durable and supply fantastic support.Best Mattress For Sale
When looking for a mattress, seek a brand that provides a cover for the mattress. This cover shields the mattress from dust as well as spills. Furthermore, a mattress that has a cover is simple to keep due to the fact that it is very easy to clean.
4. Spending plan.
The cost of this product also matters. Some mattresses are quite pricey because of their attributes and also material. As a result, when buying a mattress, ensure that it is cost effective and also of wonderful quality.Best Mattress For Sale
Sleeping far better advertises good health. That is why you need to make certain that discover a comfy mattress. Additionally, purchasing the best mattress is likewise thought about to be a terrific investment given that it will serve you for a prolonged period. Purchasing such a product could not be an easy task, yet with the help of this guide, you can be sure of finding the type of mattress you require.


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Budget friendly! Marla Armchair signature design By Ebern Designs. Marla Armchair very well made, sleek and simple. Complete your living room furniture with a modern Marla Armchair. Its graceful sturdy, attractivce and it looks expensive and a good value for the money. Marla Armchair is one of the most cofy, cozy, beautiful look and exotic Marla Armchair especially for the price and made of awesome products. Great quality, easy to assemble, delivery on time and in perfect condition. Marla Armchair is good merchandise at fair prices and amazing free shipping. Guarantee damaged claim by offering to send parts or to keep the item at a discounted price. Great buy would definitely recommend. Shop with our low-price guarantee and find great deals on Marla Armchair and more!. Reading the reviews helped you purchase.
Top Best Arm Chairs Reviews
There are not that lots of people who actually have a bar setup in your own home. For some, it could appear to be something unnatural or not suitable for a living room but when done correctly it may truly add individually to the inside of an condo or home. One thing that needs to be around the shopping list is a set of an adjustable club feces. They'll show their worth when having a person more than or web hosting a little celebration. Barstool simply provides a special contact that transforms the room. Having adjustable barstools does generate some advantages. The very first main plus is they consider very little space on the floor. They are created to be compact but comfortable sufficient. Talking about comfort and ease, barstools are not too shabby. Even if they're small, they still supply decent assistance. Some of them even have a little bit of back again assistance along with a gentle cushioned surface area. For adjustments, many of them possess a variable peak. The most important aspect which makes a club feces so easy to acknowledge is always that they swivel. A great stool was created in a way that it is hard to lower and comfortable enough. The good news is that there is an abundance when it comes to design variety. There are many significantly flexible bar stools to choose from but we had to choose just 10. Only 10 of them had been deemed buy worthy because of their quality, design and general utility. Here is what we assembled for the listing of the recommendations for that top 10 best flexible bar stools in 2018.
1.Spadaro Armchair By Orren Ellis
Read more about Spadaro Armchair By Orren Ellis
John RTA Copenhagen Selection 61 Loveseat in Marzipan was created especially for little areas. Nevertheless, technology-not only in any space: apartment, dormitory and so on. This established provides you with ample assistance. It boasts of high quality material, higher denseness froth pocketed coils, top-tier rayon dietary fiber, and powerful hard wood frame. This adds to the comfort and ease, durability, and toughness of this set. The established includes an ultra wide back again shoulder straps. The established also includes additional comfy cushions all that makes it much more comfortable. Notably, it's softly rounded arms and luxurious material allow it the outstanding appear that suits with any style. The established checklist small, therefore it's very easy to transport. It features a minor scent that fades as time passes. More to the point, the couch is extremely easy to construct. It offers the putting together tools and directions. You comfortably invest your cent listen to. It serves the reason.
2.Fredrik Armchair By One Allium Way
Read more about Fredrik Armchair By One Allium Way
With almost 100 5-star reviews, this lying loveseat is recommended because of its comfort, durability, appearance and easy assembly. In addition to gentle, but encouraging cushions, it features a gliding mechanism, so that you can put your feet up and rock and roll (although, not simultaneously.) Upholstered with ultra-durable bonded leather, this lying loveseat will resist holes, releases and stainswhich is a great thing, since it also includes a storage compartment system (where you can hide your treats, of course) and a two-mug holder. Whether youre deciding set for a Blockbuster online binge or watching football with your team, this lying loveseat provides the durability and comfort with out emptying your wallet.
3.Cowling Armchair By Corrigan Studio
Read more about Cowling Armchair By Corrigan Studio
This set includes a one left arm sofa set, two armless couch models, and one part couch set. This gives enough space to support your family and friends. The material is 100% rayon for sufficient comfort and durability. The advantage of this couch established may be the mixing and matching of seats in the available space in the room for any ideal form. And also enables fitting even in small areas. It requires just mild assembling.Additionally, it functions drive cushions for maximum comfort and ease. You might want to do this set. It works well.
4.Kitano Armchair By Lexington
Read more about Kitano Armchair By Lexington
This plush group of city-chic sofas is made to supply an adorned site. In fact, even your modest rooms might have you required to have an immaculate movie night. Place him lower to obtain a completely altered mattress. This auparavant-garde sleeper futon is accessible in different shades. This incorporates some vibrant shades out of control for example Lemon, Mild Blue, and Light Purple. Put them in your inventive research or loft to assess the exuberance. It is also available in lowering shades for example dark, dark and darkish. These nuances, once again, print a respectable part of the higher course. Using the breaking element of the back, you are able to rest for your favorite position. This couch appears wealthy with tufted material consistency upholstery. The good thing is that it's personalized with hypoallergenic filling up. A conclusive result provides a comfortable relaxation.
5.Charlcombe Armchair By Red Barrel Studio
Read more about Charlcombe Armchair By Red Barrel Studio
The best part that makes up for the lost time the glory of the buyers is its style without problems. Only for the look of the furniture, you get a nice and stylish environment. It comes in rich solid covering, imitating as incredible official clothing. While keeping an honorable stature, the fabric upholstery could be cleaned very easily. You shouldn't rue following turning over a cup of drink in your good couch. You just need to wash the stain for ever and ever exactly if this hits the furniture. Even though good repute accompanies treat, it's not the situation here. This amazing sofa is given with a contour growth and development of wood. You are more unwilling to hear squeaks and wobbling seems.
6.Royal Kahala Armchair By Tommy Bahama Home
Read more about Royal Kahala Armchair By Tommy Bahama Home
This reclining loveseat takes the second place because its a super affordable, super comfortable choice that can participate in most home decorations designs. Its wood body is padded with circles (for many springtime) and-denseness froth (for some gentle), and padded with dark brown fake leather that makes it an extremely-flexible furniture piece. Add it to the person cavern for any comfy spot to view the game (and dont worry about any spillsits vinyl fabric furniture makes cleanup simple) or perhaps your living room with a few decorative throw pillows for that perfect spot to cozy up after a long day. Actual-existence clients adore this lying loveseat because its comfortable, durable, simple to assemble 1 rater even mentioned that they could assemble two units within forty-five minutes! and delivery in the vendor is a breeze.
7.Chad Armchair By Corrigan Studio
Read more about Chad Armchair By Corrigan Studio
This group of RTA couches is available in various furniture textures. Some of them include bonded leather, linen, corduroy, linen texture, rayon. All you need is to choose the correct tapestry in significance for the balanced requirements. Accessible materials provide an simple-to-clean element. A attribute that suggests its versatility to resist food and drinks. The luxurious chair and back soft cushions vote in support of a reducing-advantage look. The sq . molded equip that starts just over them enhances the elegance. You will find the comforts and gentle styles that strike your entrance.
8.Boxford Armchair By Everly Quinn
Read more about Boxford Armchair By Everly Quinn
This set features a one remaining equip couch established, two armless couch sets, and something part sofa set. This provides sufficient room to support your family and friends. The material is 100% rayon for enough comfort and durability. The advantage of this couch established is the mixing and matching of chairs in the available space in the room for a ideal form. As well as allows for fitting even in little rooms. It takes just mild assembling.Additionally, it features push cushions for optimum comfort and ease. You might want to try this established. It works nicely.
9.Liam Armchair By GabBy
Read more about Liam Armchair By GabBy
While the rear of this sofa hints at the Chesterfield, using its series of tufting, a tuxedo sofa has solution, more angular outlines. It is said to possess been the bellwether more modern styles in the 1920s. While some say this sofa style takes a title from Tux Recreation area in New York, it is also considered called following the traditional fancy mens suit. You are able to determine a tux couch by its arms that are identical peak because the back. The tufting on the back of the sofa and it is rectangular silhouette are also traditional qualities. Cushions add comfort for this high-armed design. Also, while the sofa above from Upcountry is padded in leather, this well-liked design is usually done in textiles of all types, including the very trendy velvet.
10.Theo Armchair By Fairfield Chair
Read more about Theo Armchair By Fairfield Chair
This reclining loveseat requires the 2nd spot simply because its an excellent affordable, super comfy choice that can fit in with most home dcor styles. Its solid wood body is cushioned with coils (for some springtime) and high-denseness froth (for many soft), and padded with dark brown fake leather which makes it an extremely-versatile piece of furniture. Add it to the man cave for any comfy destination to watch the game (and do not worry about any spillsits vinyl upholstery makes clean-up easy) or your family room with a few decorative toss pillows for the perfect place to cozy up after a long-day. Real-life clients adore this lying loveseat simply because its comfortable, durable, simple to put together one rater even mentioned that she was able to assemble two models within 45 minutes! and shipping in the vendor is a breeze.

domain: design


The Scoop: Mustard on the beat, hoe is coming out with a new project that’s sure to bang heavy for the summer. The L.A. beatsmith, DJ Mustard announced that his new project 10 Summers: The Mixtape Vol. 1 will be dropping on July 23.
The 25-year-old producer recently went on IG and said “This ain’t my album this ain’t ketchup 2 this is my label mixtape for my label !!! #10summers,” which suggests that he’s ready to put the team in full force.
The Spin: In his Breakfast Club interview last year, Mustard explained that the name of his label signifies that his reign will last 10 whole summers. Pretty bold statement, but with his track record we can’t deny it.
The tracklist for the upcoming mixtape can be seen below. Some of the features consist of Ty Dolla $ign, IAMSU!, Game, Dom Kennedy and more.
Intro ft. RJ, Big Mike, Choice
Body Count ft. RJ, Skeme
The Shooters (skit) ft. Drakeo
Shooters ft. Game, RJ, Skeme, Joe Moses
Tool ft. Teecee4800, Jay 305
Trippin Off Hoes ft. RJ, Choice
You Know It ft. Nef The Pharaoh, Splacc, Big Mike
I Be Wit ft. Choice
All About You ft. Teeflii, Choice, Casey Veggies
So Broke (skit) ft. Drakeo
Broke Boy ft. IAMSU, Choice, RJ
Overdose ft. Teeflii, IAMSU, Choice
The Uchies (skit) ft. Drakeo
Mr. Big Bank Budda ft. Drakeo
Ice Cream ft. Dom Kennedy, Ty Dolla $ign
Love ft. Justine Skye
Down Low ft. Teeflii
The Question: Are you looking forward to 10 Summers? Let us know in the comments!


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Plan ahead and know what you want. If you take the time to look at different modern home plans, you will have a much better idea of what you can expect from your designer. Once you know what you want, you can find a professional that fits your style and demands.
Nowadays, due to environmental issues and lack of availability wooden furniture have become most expensive choices. Therefore, a majority of people are going for steel or fiber options. Modern designer furniture uses best quality steel or fiber along with leather or fabric.
Plan your budget accordingly so that you don't get your hopes too high or settle for less than you deserve. That is, plan your budget based on what you can afford. If a half-million dollar home is in your dreams, make sure you can finance it - visit your accountant and bank manager beforehand so you know what budget you can realistically work with.
Choosing a home design is all about determining how much space you need. You can find modern home plans in a variety of shapes and sizes. This means that you can get the space that you need while also getting the design that you enjoy, no matter what that might be. The goal of building your home, after all, is to get the dream home that you always wanted. Hiring an architect will depend on a few things.


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HARRISON -- Two Newark men were arrested in separate drunken-driving incidents about a half hour apart on Friday, police said.
Around 10:30 p.m., police responded to Church Square on a report of an accident, police said. Responding officers saw that a Chevy Minivan had backed into a parked car, police said.
Police said the driver, Francisco Godoy, 52, of Newark, had driven the wrong way down the one-way Church Street. When Godoy realized he was going the wrong way, he tried to back his van down Church Street and struck a parked car, police said.
Police said at the time of the incident, Godoy's blood alcohol content was .21, more than twice the legal limit of .08.
Godoy was arrested and later released on a summons for driving while intoxicated, police said.
A half hour later, police watched a Ford SUV speed through a stoplight on Frank E. Rodgers Boulevard at Sussex Street, police said.
Police stopped the vehicle shortly after the incident and found that the driver, Ueslei DaSilva, 33, of Newark, smelled of alcohol and had bloodshot and watery eyes, police said.
DaSilva failed a field sobriety test, police said, and he was charged with driving while intoxicated, driving while intoxicated in a school zone and failure to observe a traffic signal, police said.
Police said that DaSilva was held at Hudson County jail following the incident after he was discovered to have a warrant from Kearny for $2,500.

domain: news


"We get brilliant results consistently from average people managing brilliant processes. We observe that our competitors often get average (or worse) results from brilliant people managing broken processes"
...Eiji Toyoda of Toyota Motors
With continuously changing business trends, there is a lot of pressure on the organisation to accommodate newer tasks, often leading to sub-optimal processes. While most businesses group work together in functional silos, the definition of value is often skewed by each silo. While each silo attempts to optimise its own operations, it does not have full visibility how that impacts the value stream and affects the end customer.
Tasks inevitably “fall between the cracks” at interfaces between the functional silos, as today’s business processes span across multiple functions. Tremendous resources are wasted by “picking up the dropped baton” and “getting the process back on track”. Failing to optimise the overall process leads to value erosion in the value stream, ultimately the end customer receives lesser value.
How White Spaces Consulting can help you?
We are committed to improving business performance and results, NOT delivering pre-packaged, linear solutions.
Our approach to Business Process Optimisation focuses on the customer’s needs. We believe that value perception is defined by the customer, and not by the company, manager or an employee. We examine the value stream vis-_-vis the “as-is” business processes, and identify sub-optimal, repetitive, redundant, and non-value-adding activities. We re-define the “to-be” business processes concomitant with the value stream.
At White Spaces Consulting, we use process-based techniques and deliver performance improvements by eliminating non-value-added work, thus helping clients generate superior Return on Investment (ROI) through:
- Improving efficiency - optimising business processes using Lean Management to reduce or eliminate “wastes” like excess inventories, over-production, quality rejections, waiting time, space, energy and even lack of information and knowledge sharing across the business processes.
- Reducing costs - identifying cost reduction opportunities by rationalising resource requirements across the entire value chain, leading to better cost and working capital management, and improved “bottom line”.
- Increased productivity - minimising number of steps and likely points of failure, and driving decision making to the employee at the “moment of truth” with the customer, within specified delegations to improve profit per employee, employee empowerment, and ultimately both customer and employee satisfaction.
- Better process control - improved management of business processes by standardizing working procedures as far as possible, and rationalising control mechanisms. Improving process risk governance and providing better process visibility to the process owners and the executive management.


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Cubby Conrad: Learning to look for the positives
07/13/2015 02:34 PM EDT - Sometimes I feel like I have to turn off the nightly news and remind myself of all the blessings in life; times when I feel like the more I know about people and some of their horrific actions, the more I love animals; and times when I have to remind myself to just take a moment, shut down my Full story
Cubby Conrad: Light at the end of the Old Age tunnel
06/02/2015 07:02 AM EDT - I'm starting to notice a rather perplexing trend: the older I get, the faster my good years are behind me. Full story
US court says drug-sniffing dog fails the smell test
CHICAGO (AP) — Lex the police dog from central Illinois is far from top dog in drug-sniffing skills. Full Story
Post-White House, Sam Kass to be food analyst for NBC News
BOSTON (AP) — After six years of helping the Obama administration determine the nation's food policy, former White House chef and food policy adviser Sam Kass will now report on it. Full Story
Is Ben Affleck dating kids' nanny?
The actor's reps deny a report that he started to get close with his kids' 28-year-old nanny during his separation from Jennifer Garner.


WASHINGTON (Reuters) - The White House on Tuesday along with companies such as Amazon.com Inc, Alphabet's Google and Best Buy will announce an initiative that allows Americans to identify devices that are less vulnerable to cyberattacks.
A new certification and labeling program would raise the bar for cybersecurity across smart devices such as refrigerators, microwaves, televisions, climate control systems and fitness trackers, the White House said in a statement.
Retailers and manufacturers will apply a "U.S. Cyber Trust Mark" logo to their devices and the program will be up and running in 2024.
The initiative is designed to make sure "our networks and the use of them is more secure, because it is so important for economic and national security," said a senior administration official, who did not wish to be named.
The Federal Communications Commission will seek public comment before rolling out the labeling program and register a national trademark with the U.S. Patent and Trademark Office, the White House said.
Other retailers and manufacturers participating in the program include LG Electronics U.S.A., Logitech, Cisco Systems and Samsung.
In March, the White House launched its national cyber strategy that called on software makers and companies to take far greater responsibility to ensure that their systems cannot be hacked.
It also accelerated efforts by agencies such as the Federal Bureau of Investigation and the Defense Department to disrupt activities of hackers and ransomware groups around the world.
Last week, Microsoft and U.S. official said Chinese state-linked hackers secretly accessed email accounts at around 25 organizations, including at least two U.S. government agencies, since May.
(Reporting by Nandita Bose in Washington; Editing by Jacqueline Wong)