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Libido The bodily and emotional urge or feeling of want for some kind of intercourse, which can include masturbation Intersex A socially constructed Sexual Enhancement Pills class that displays real biological variation Some intersex situations are Turner Syndrome, Androgen Insensitivity Syndrome, Klinefelter s Syndrome, MRKH and Congenital Adrenal Hyperplasia.
You can also start on this dose in case you have well being circumstances that make higher doses much less secure, corresponding to hypertension, or if you re taking drugs that could interact with Viagra Viagra is a medicine for erectile dysfunction that can assist you to to get and hold an erection It works by relaxing your blood vessels and growing the blood circulate to your penis.
Researchers found in 2014 that Tribulus Terrestris elevated the female sex drive A 4 week randomized research has demonstrated that Tribulus Terrestris 750 mg improved lubrication, desire, and satisfaction in women A separate research in 2012 discovered the Tribulus Terrestris resulted in an enchancment within the sexuality of male rats.
- Erectile Dysfunction (Mayo Foundation for Medical Education and Research)
- Erectile Dysfunction (ED) (American Academy of Family Physicians) Also in Spanish
- Erectile Dysfunction (ED) (National Institute of Diabetes and Digestive and Kidney Diseases) Also in Spanish
Diagnosis and Tests
- Testosterone Levels Test (National Library of Medicine) Also in Spanish
Treatments and Therapies
- Erectile Dysfunction Herbs: A Natural Treatment for ED? (Mayo Foundation for Medical Education and Research) Also in Spanish
- Erectile Dysfunction: Viagra and Other Oral Medications (Mayo Foundation for Medical Education and Research) Also in Spanish
- Hidden Risks of Erectile Dysfunction "Treatments" Sold Online (Food and Drug Administration)
- Kegel Exercises for Men: Understand the Benefits (Mayo Foundation for Medical Education and Research) Also in Spanish
- Penile Implants (Mayo Foundation for Medical Education and Research) Also in Spanish
- Penis Pump (Mayo Foundation for Medical Education and Research) Also in Spanish
- Testosterone Therapy: Potential Benefits and Risks as You Age (Mayo Foundation for Medical Education and Research) Also in Spanish
- Yohimbe (National Center for Complementary and Integrative Health)
- All-Natural Tips to Improve Your Sex Life: Exercise, Diet Changes May Help Reverse ED (Erectile Dysfunction) (Harvard Medical School)
- Fertility and Sexual Side Effects in People with Cancer (American Cancer Society) Also in Spanish
- Cardiovascular Implications of Erectile Dysfunction (American Heart Association)
- Erectile Dysfunction (Mayo Foundation for Medical Education and Research) Also in Spanish
- Erectile Dysfunction and Diabetes (American Diabetes Association)
- Erectile Dysfunction: A Sign of Heart Disease? (Mayo Foundation for Medical Education and Research) Also in Spanish
- Low Testosterone and Men's Health (Hormone Health Network) Also in Spanish
- Sex and the Man With Cancer (American Cancer Society) Also in Spanish
- Bent Penis (Mayo Foundation for Medical Education and Research) Also in Spanish
- ClinicalTrials.gov: Erectile Dysfunction (National Institutes of Health)
- ClinicalTrials.gov: Impotence (National Institutes of Health)
Journal Articles References and abstracts from MEDLINE/PubMed (National Library of Medicine)
Find an Expert
- Find a Urologist (Urology Care Foundation)
- National Institute of Diabetes and Digestive and Kidney Diseases
- Drugs that may cause impotence (Medical Encyclopedia) Also in Spanish
- Erection problems (Medical Encyclopedia) Also in Spanish
- Erection problems - aftercare (Medical Encyclopedia) Also in Spanish

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As Nigeria joins other countries across the continent at the African Climate Week currently holding in Accra, Ghana, Actionaid Nigeria has advised the nation to adopt ‘agroecology’ as the focus of her adaptation plan.
According to the group’s Country Director, Ene Obi, “Nigerian farmers who depend on predictable rainfall patterns are harvesting lower yields or even struggling to grow food” as a result of the biting effects of climate change.
According to a statement issued by its Communications Coordinator, Lola Ayanda, the non-governmental organisation called on President Muhammadu Buhari to act to protect farmers and food supplies from global warming.
Mr Obi said; “We have all noticed that the climate is changing and that the seasons have been disrupted as a result of global warming. In recent years in Nigeria, we have experienced more frequent weather extremes, sometimes seeing droughts one year and floods the next. Rainy seasons arrive early, or late, or are far shorter than usual.
“Therefore, we’re calling on the President of Nigeria to recognise the value of agroecology and start promoting it as a real and future-oriented solution to help food systems cope with the impact of climate change.”
The statement said rural communities that depend on farming for food and income are vulnerable to climate change.
“Soils are drying up quickly due to higher temperatures. New invasions of pests are marching through fields. Fodder and pasture for livestock is becoming harder to find. With hot seasons lasting longer, many communities now find that their sources of water are drying up,” Mrs Obi added.
She, however, noted that amid the new terrifying reality is the good news of clever strategies available that can help to lessen the harm that extreme weather can wreak on food production and communities. “These innovative strategies include training farmers, particularly women, who grow some 70 per cent of Nigeria’s food, and encouraging them to use climate-friendly agroecological farming techniques which sadly are often dismissed by the agribusiness industry as less productive or modern than the industrial agrochemicals and hybrid seeds that the industry wants to sell to farmers.”
She further stated that; “Nigeria needs a national-level mobilisation to ensure that our agriculture, our water, our infrastructure, our safety and all aspects of our lives are climate-proofed against the further disruptions that we know are coming. One of the most important actions our government could take now would be to develop a National Adaptation Plan (NAP).
“We need the government to take swift action to bring together the right stakeholders and to develop an effective plan that can protect our country, our citizens and our food systems from climate change.”
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The Osun State Governor, Ademola Adeleke, on Friday, welcomed the judgement of the Court of Appeal affirming his victory in…
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ICON Robotics can design and build a Case Packing or Case Erecting machine to suit your application. Depending on the task, we can also explore using a robotics for the application which combines high-speed case packing with and the durability and flexibility of a robot.
The most cost effective and versatile RSC Case Erector available. Designed and built to overcome the traditional issues commonly faced by these machines, namely, cases of variable quality, and cases with a high content of recycled material.
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Product is transferred from the filling/cartoning lines onto the infeed conveyors of the Pack Assist unit. Product is collated and stacked automatically into the correct case format and loaded into an RSC case which is erected by the operator. Once loaded, the case is easily transported directly to a top and bottom tape sealing machine.


text:
- 1 What is the difference between physical activity and physical fitness quizlet?
- 2 What is the difference between physical activity and exercise give at least two examples?
- 3 What three body systems does physical activity improve?
- 4 Who benefits physical activity?
- 5 What are 3 examples of physical activity?
- 6 Is dancing a physical activity or exercise?
- 7 What are the five elements of physical fitness?
- 8 What are the 3 most important body systems?
- 9 How does the body respond to physical activity?
- 10 What does physical activity do to your body?
- 11 What are the 4 types of physical activity?
- 12 What are 10 benefits of physical activity?
- 13 What are the 10 physical activities?
What is the difference between physical activity and physical fitness quizlet?
Physical activity is any form of movement that causes your body to use energy. Physical fitness is the ability to carry out daily tasks easily and has enough reserve energy to respond to unexpected demands.
What is the difference between physical activity and exercise give at least two examples?
Physical activity is movement that is carried out by the skeletal muscles that requires energy. In other words, any movement one does is actually physical activity. Exercise, however, is planned, structured, repetitive and intentional movement intended to improve or maintain physical fitness.
What three body systems does physical activity improve?
There are many different systems involved in when we exercise, the three main ones are the Respiratory system which is involved in breathing the circulatory system which is about circulation of blood around the body and finally the muscular system and finally the Muscular system which is about how we move.
Who benefits physical activity?
Regular physical activity can:
- improve muscular and cardiorespiratory fitness;
- improve bone and functional health;
- reduce the risk of hypertension, coronary heart disease, stroke, diabetes, various types of cancer (including breast cancer and colon cancer), and depression;
What are 3 examples of physical activity?
Some examples of physical activity are:
- Going for a walk, bike, or run (join our indoor walking program).
- Doing household chores.
- Taking the stairs instead of the elevator.
- Playing at the park.
- Raking leaves or shovelling snow.
Is dancing a physical activity or exercise?
Dancing is a whole-body workout that’s actually fun. It’s good for your heart, it makes you stronger, and it can help with balance and coordination. A 30-minute dance class burns between 130 and 250 calories, about the same as jogging.
What are the five elements of physical fitness?
5 Components of Physical Fitness
- Cardiovascular Endurance.
- Muscular Strength.
- Muscular endurance.
- Body Composition.
What are the 3 most important body systems?
The main systems of the human body are:
- Circulatory system / Cardiovascular system:
- Digestive system and Excretory system:
- Endocrine system:
- Integumentary system / Exocrine system:
- Immune system and lymphatic system:
- Muscular system:
- Nervous system:
- Renal system and Urinary system.
How does the body respond to physical activity?
As soon as you start exercising your body will respond by stimulating and inhibiting physiological processes that will allow you to exercise more efficiently. For example, your cardio-respiratory system increases above what it would be at rest, whereas the digestive system slows down.
What does physical activity do to your body?
Regular physical activity can improve your muscle strength and boost your endurance. Exercise delivers oxygen and nutrients to your tissues and helps your cardiovascular system work more efficiently. And when your heart and lung health improve, you have more energy to tackle daily chores.
What are the 4 types of physical activity?
Research has shown that it’s important to get all four types of exercise: endurance, strength, balance, and flexibility. Each one has different benefits. Doing one kind also can improve your ability to do the others, and variety helps reduce boredom and risk of injury. 5
What are 10 benefits of physical activity?
Top 10 Benefits of Physical Activity
- Improve your memory and brain function (all age groups).
- Protect against many chronic diseases.
- Aid in weight management.
- Lower blood pressure and improve heart health.
- Improve your quality of sleep.
- Reduce feelings of anxiety and depression.
- Combat cancer-related fatigue.
What are the 10 physical activities?
- Water aerobics.
- Jogging and running.
- Aerobic exercise classes.
- Bicycle riding (stationary or on a path)
- Some gardening activities, such as raking and pushing a lawn mower.

domain: biology


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domain: chemistry


Elgin will bid to become a city as part of the Queen’s platinum jubilee celebrations.
At a meeting of Moray Council’s corporate committee on Tuesday, members unanimously agreed to go-ahead with an application.
As part of the celebrations to mark the monarch’s 70-year reign local authorities across the country can apply for city status in a civic honours competition.
Dumfries and Dunfermline have already confirmed bids and any new city would join the ranks of Scotland’s seven – Aberdeen, Dundee, Edinburgh, Glasgow, Inverness, Perth and Stirling.
Council leader and SNP councillor for Elgin South Graham Leadbitter encouraged members to get behind the bid.
He said: “Elgin Community Council wrote to us saying they would like to see a bid put forward.
“This has all come together quite well with a number of discussions and I believe there’s broad support for this.
“While Elgin has the right to call itself a city because it was decreed a long time ago, it isn’t technically a modern city.
“If we can have that re-classed there will be opportunities for the whole of Moray, the north-east and Highlands.”
Mr Leadbitter added the six Elgin councillors had agreed to provide £2000 finding from the common good fund for the bid, which is being backed by the community council and Elgin Business Improvement District.
Conservative councillor for Keith and Cullen Donald Gatt supported the application.
He said: “Some would say Elgin has never lost its city status but if we can cement that in modern terms it will be for the greater good.”
If successful, city status will bring financial benefit to the whole of Moray and end years of speculation on Elgin’s identity.
There has been confusion for generations over the town’s standing with many businesses as well as the local football club using city in their title, but it is not officially recognised as one.
Previously bids were sought for the monarch’s golden jubilee in 2002 and diamond anniversary in 2012 which proved successful for Stirling and Perth respectively. Inverness became a city in a similar contest in 2000.
A successful bid will have to highlight the distinctive identity of Elgin including its culture, heritage, history, traditions, royal connections and any communities or residents who have made a significant contribution to the area.
Up to 50 photographs of landmarks in what could become the city centre will be included along with a map showing parks, tourist attractions, leisure and entertainment venues as well as the main tourist routes.
Information on population, sport centres and shopping areas will also form part of the bid.
Any local authority in the United Kingdom, a crown dependency or overseas territory can enter a city status application.
There is also a parallel competition for existing UK cities to apply for a lord mayor or provost position.
Applications need to be submitted to the Cabinet Office by 4pm on Wednesday, December 8.
Story by local democracy reporter Hazel Lawson.
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The paper presents a novel and economic manufacturing process for microlens arrays (MLAs). This process uses micromilling machining, PDMS casting, and hybrid bonding between a glass substrate and PDMS membrane to create a microfluidic chip which is used for manufacturing MLAs on a PDMS substrates. MLAs of various diameters were fabricated for experiments, including 1000 μm, 500 μm, and 200 μm. The sag height of the MLAs is easily adjusted by controlling the pressure inside the microchannel to deform the PDMS membrane. Multiple experiments were conducted to characterize the performance of MLAs, the results of which demonstrate: (1) this fabrication process is able to manufacture MLAs with various dimensions and the diameter of an MLAs is determined by the size of micromilling bit and cutting path; (2) the sag height and curvature of MLAs can be controlled by the PDMS membrane thickness and the hydraulic pressure inside the microchannel; (3) an optical system was built to investigate the uniformity of MLAs and the experiment results showed uniform focal length of MLAs; (4) the resulting MLAs magnify tiny objects and significantly enhance the fluorescence signal emitted from the microchannel
© 2017 Optical Society of America
Expansive growth in the optoelectronic industry and intelligent manufacturing is fueling interest in methods for the efficient fabrication of precise optical components. Microlens arrays (MLAs) are widely applied in optical communication , flat panel display modules , optical storage , shack-hartmann wavefront sensors , beam shaping for illumination , and light gathering for solar collectors . Numerous fabrication methods have been developed for the fabrication of MLAs on polymeric substrates, including photoresist reflow [7–10], laser ablation [11,12], gray-scale photolithography [13–15], micro-jet fabrication , hot embossing [17–19], electroforming , surface-energy driven process , and electrically template dewetting .
A number of researchers have integrated adjustable microlenses into microfluidic platforms. Chronis et al.  reported an elastomer-based tunable liquid-filled microlens array fabricated using soft lithography. The focal length of the microlenses is pneumatically controlled via a microfluidic network to pressurize each microlens evenly, resulting in devices with a focal length ranging from hundreds of microns to several millimeters. Chen et al.  developed a controllable PDMS microlens on a PDMS substrate, wherein the PDMS top layer was deformed through the injection of pneumatic pressure from the bottom microchannel resulting in a spherical microlens with a diameter from 600 to 1400 μm. Experiment results reveal that the focal length of the microlens was from 3.82 mm to 10.64 mm. In a similar method, Jeong et al.  took advantage of the flexibility of PDMS to fabricate biconvex and meniscus lenses on a PDMS substrate using micromolding and photopolymer microdispensing technologies. They used this technique to create a microdoublet lens capable of minimizing optical aberrations for use in optical communications and medical imaging. Ren et al.  demonstrated a liquid lens that a focal length that can be controlled by a servo motor. The lens cell comprises an elastic membrane with planar glass plate, peripheral sealing ring, and fixed volume of liquid in a lens chamber. The volume of liquid injected into the lens cell alters the curvature and focal length to achieve a maximum focal length of approximately 6 m with maximum radius of approximately 2.7 m. Lee et al.  used an electromagnetic actuator to deform a PDMS membrane for use as a microlens. Changing the current input into the electromagnetic actuator proved effective in adjusting the focal length; however, the current tends to generate heat after extended operation.
While most of the methods for MLAs were based on photolithography and physical phenomenon, we herein demonstrated a novel and economic method for fabricating spherical MLAs using micromilling process and casting techniques with PDMS and ultraviolet (UV) curable adhesive. To make this approach closer to the commercialization of MLAs with injection molding machine, the final step of PDMS casting could be replaced with electroplating metal mold inserts for mass production. Micromilling is a rapid and cost-efficient tool for the fabrication of micro-scale features on polymeric substrates . In this study we used micromilling to fabricate the 1st mold insert on a poly(methylmethacrylate) (PMMA) substrate to initiate the manufacture of the MLAs. PDMS casting and UV adhesive casting were then used sequentially to manufacture a PDMS MLAs. Creating micro pillar features within the PMMA substrates and adjusting the pressure inside the bottom microchannel make it possible to deform the top PDMS membrane in order to produce a well-defined MLAs, in terms of the sag height, curvature, and focal length. To characterize the uniformity and performance of the resulting MLAs, multiple experiments were conducted to elucidate the following: (1) the relationships among membrane thickness, sag height, focal length, and pressure with the microchannel, as observed in MLAs with diameters of 1000 μm, 500 μm, and 200 μm; (2) the magnification and enhancement of fluorescence signals from the microchannel when the MLAs is mounted over a microchannel, and (3) understanding the uniformity of the MLAs with an home-built optical system.
Figure 1 illustrates the concept underlying the proposed fabrication process, in which a flexible PDMS membrane is used to form a spherical MLAs and the bottom microchannel is used to deliver the precise pressure required to deform the top PDMS membrane. Figure 1(a) shows the micromilled mold inserts used in the fabrication of the PDMS membrane. A cast PDMS membrane was formed from the top and bottom PMMA substrates and subsequently bonded to a glass substrate with the aid of plasma treatment [Fig. 1(b)]. Liquid is injected into the microchannel of the glass-PDMS hybrid microfluidic chip, such that the pressure accumulating within the chamber causes the PDMS membrane to deform into a spherical shape [Fig. 1(c)]. The deformed PDMS membrane is used as a 2nd mold for UV adhesive casting. The degree to which the PDMS deforms is easily controlled by adjusting the pressure inside the micro chamber. UV adhesive is poured over the membrane and quickly hardened under exposure to UV radiation for use as a 3rd mold in subsequent PDMS casting [Fig. 1(d)]. In the final step, the PDMS casting is used to transfer the spherical concave shape from the UV substrate to the PDMS substrate [Fig. 1(e)]. This PDMS MLAs [Fig. 1(f)] was then characterized in a number of experiments. In this proposed method, the diameter of the MLAs is determined by the dimensions of the standing structure, as shown in Fig. 1(a). The thickness of the PDMS membrane is determined by the height of the standing structure, as shown in the Fig. 1(a). The pressure accumulated inside the chamber is used to control the degree to which the PDMS membrane deforms [Fig. 1(c)], this step determines the physical dimension of the final MLAs.
3. Fabrication process
3.1 Micromilling 1st polymeric mold insert
Substrates of PMMA material were cut to 50 mm x 37.5 mm x 3 mm and then inscribed with micro features using a micromilling machine. The micromilling machine used in this study includes five major components: a spindle (E3000c, Nakanishi, Japan), a laser non-contact tool setting system to reset cutting datum following the exchange of milling bit (NC4, Renishaw, United Kingdom), a numerical controller (M515i, LNC Technology Co. Ltd., Taiwan), a compressed air/oil coolant system, and a milling bit holder for tool exchange. Air only or a mixture of oil and air was supplied to the cutting surface of the PMMA substrate via a nozzle throughout the cutting process. We employed a 2-flute end mill bit with a diameter of 200 μm (Taiwan Microdrill Co. Ltd., Taiwan) for manufacturing the micro pillar features on the PMMA substrates. Figure 1(a) presents the top and bottom PMMA mold inserts used for the manufacture of the PDMS membrane. Carefully designing the height of the micro pillar features and the gap distance between the two PMMA substrates made it possible to adjust thickness of the PDMS membrane. Figure 2(a) presents the micromilled bottom mold insert, Fig. 2(b) illustrates the micromilled bottom mold insert, and Fig. 2(c) presents an enlarged image from Fig. 2(a) showing the circular standing structures placed over the microchannel structure. As shown in Fig. 2(c), the diameter of the circular standing structures was 200 μm and the width and depth of the microchannel were 200 μm, respectively.
3.2 PDMS casting and bonding for microfluidic platform as 2nd mold insert
Following assembly of the top and bottom mold inserts, a standard PDMS casting process was used to manufacture PDMS membranes . The PDMS (Sylgard 184, Dow Corning) is prepared by mixing the pre-polymer and the curing agent in the weight ratio of 10:1. After degassing and the PDMS mixture was poured on the mold inserts, then the mold insert with PDMS mixture was put in an oven for 1.5 hours at 80°C. After demolding, the cast membrane was then bonded to a glass substrate to form a hybrid microfluidic chip. Prior to bonding, the PDMS membrane and the glass substrate were both exposed to plasma (PDC-32G, Harrick Plasma) for 2 minutes in a vacuum chamber. The PDMS was then brought in contact with the glass substrate to produce a hybrid chip suitable for experiments. Figure 2(d) presents the circular structures and microchannels on the PDMS membrane casting from the micromilled mold insert shown in the Fig. 2(c). Figure 3(a) shows the bonded hybrid microfluidic chip. The two standing structures located on the edge of the PDMS membrane were used for the connection of tubing and the wall structures around the microchannel were used to define a boundary for UV adhesive casting. Figure 3(b) presents the hybrid microfluidic chip in cross-section, clearly showing how liquid was injected into the chamber through the bottom microchannel. The pressure inside the chamber causes the PDMS membrane to deform into a spherical shape. As shown in Fig. 3(b), the thickness of the membrane is related to the degree of deformation and is therefore strongly related to the sag height and focal length of the resulting MLAs.
3.3 Replication using UV adhesive to produce 3rd mold inserts
The completed hybrid microfluidic chip was then used as a 2nd mold to produce a 3rd mold insert on a UV curable substrate [Fig. 1(c)]. A manual syringe pump was connected to the hybrid microfluidic chip and liquid was pumped to deform the PDMS membrane. Figure 4(a) shows red food dye injected into the hybrid microfluidic chip and Fig. 4(b) presents a close-up of the MLAs on the PDMS membrane. One can clearly make out the microchannels carrying red food dye beneath the MLAs, which caused the circular PDMS membrane to deform into a convex shape. UV curable adhesive (Slink P21-A, Slink Adhesive Technology) was then poured onto the PDMS membrane and sequentially exposed to UV radiation for 108 seconds under the irradiation intensity of 50 mW/cm2 (Xlite 500, OPAS, Taiwan). Following solidification, the UV substrate was demolded from the PDMS membrane for use as a 3rd mold insert for the final PDMS MLAs.
3.4 PDMS casting of microlens array (MLAs)
The UV mold insert was fixed within a fixture [Fig. 1(e)] in order to control the thickness of the final PDMS MLAs. Micromilling was used to form cavities in the PMMA substrate, into which was placed the UV mold inserts for subsequent PDMS casting. Again, standard PDMS casting was applied on the PMMA fixture with multiple UV mold inserts to manufacture PDMS MLAs [Fig. 1(f)]. Figure 4(c) shows the final MLAs on the PDMS substrate. As shown in Fig. 4(d), this fabrication method enables the production of novel MLAs with various curvatures and sag heights in various locations of the same substrate. In other words, this approach is applicable to the creation of localized MLAs.
This focus of this paper is to introduce this rapid and efficient fabrication method, elucidate the limitations for MLAs, and evaluate the uniformity and overall performance of MLAs. Several experiments were conducted to characterize the MLAs, including the following: (1) the relationships among membrane thickness, hydraulic pressure inside the microchannel, sag height, and focal length; (2) the effectiveness of the MLAs in magnifying tiny objects and enhancing fluorescence signals emitted from microchannels; and (3) the uniformity of MLAs, which is crucial to optical performance.
4.1 Characterization of microlens
As shown in Fig. 1(c), the sag height of the final PDMS MLAs was largely determined by the deformation of PDMS on the hybrid microfluidic chip. To elucidate this effect, we built a system by which to measure the deformation of the PDMS on the hybrid microfluidic chip, as shown in Fig. 5(a). The system included a sensor (PS100-10 Bar, Yalab, Taiwan) to measure the pressure accumulated within the microchannel, a manual syringe pump to push the liquid into the microfluidic chip and deform the PDMS membrane, and a microscope to record the deformation of the PDMS (as viewed from the side) for the estimation of sag height. Figure 5(b) presents the actual system used in the experiments. Our experiment results help to illustrate the relationship between hydraulic pressure and sag height as a function of membrane thickness and diameter.
4.2 Magnification and characterization of fluorescence by MLAs
The second experiment dealt with optical performance, wherein the MLA was used to magnify tiny objects and enhance the fluorescence signal from the microchannel when integrated atop a microfluidic chip. To observe the effects of magnification, the MLAs was placed over a paper covered with tiny black dots. A tool microscope (SAGE 2600, SAGE, Taiwan) was then used to capture images above the MLAs. To quantify the degree to which the MLAs enhances fluorescence signals, we micromilled a straight microchannel on a polymeric substrate, which was then bonded to another piece of PMMA substrate using ethanol solution. This fabrication process was described in a previous paper . The difference between fluorescence signals obtained with/without an MLAs atop the microfluidic chip was determined by placing the PDMS MLAs over the microchannels and introducing a fluorescence solution into the microchannel using a syringe pump. The fluorescence solution contained fluorescence particles (Leuchtstoffwerk, Breitungen GmbH, Breitungen, Germany) and DI water (the fluorescent particles were undissolved). The excitation wavelength of the fluorescence particles was 465 nm and the emission wavelength was 553 nm. A fluorescence microscope (Axio Imager A1, Zeiss) was used to measure the fluorescence signal emitted from the microchannel. After capturing the image, Image J software was used to quantify the intensity of the fluorescence signal and illustrate any differences.
4.3 Uniformity of MLAs
To understanding the uniformity of the MLAs fabricated from this proposed method, an optical system was built to investigate the focal length of MLAs. Figure 6(a) shows the components of this optical system, including the laser, lens combination for beam expansion, polarizer, and CCD camera. The fabricated MLAs is fixed on a x-y table, hence the MLAs can move either far away or closer to the CCD camera, to determine the focal length of the MLAs. Figure 6(b) shows the experiment setup from the top view. Once the image was captured by the CCD camera, the image will be imported into Matlab for intensity analysis. The analyzed result can be used as information to understand the uniformity of the MLAs in terms of the focal length or curvature.
5. Experiment results and discussion
5.1 Relationships among sag height, focal length, pressure, and membrane thickness
Figure 7(a) presents images of a PDMS microlens with a diameter of 200 μm, which was deformed through the application of various amounts of pressure. When the accumulated pressure was increased from 10 kpa to 120 kpa, the sag height increased from 5 μm to 96 μm. Figure 7(b) presents profiles of sag height as a function of pressure. With pressure of less than 90 kpa, deformation occurred around the central area of the PDMS membrane, such that the diameter of the microlens was smaller than 200 μm. When the pressure was increased to 90 kpa, the diameter of the microlens increased to 200 μm. At pressure values above 90 kpa, the diameter of the microlens exceeded 200 μm, due to deformation of the area surrounding the PDMS microlens. The experiment results clearly illustrated that diameter and sag height of the MLAs are both affected by the applied pressure, and the diameters of the final lenses are not always equal to the diameters of the standing posts on the micromilled mold inserts. Figure 8 presents the sag height of the microlens produced using PDMS membranes of various thicknesses and various pressure values. Figures 8(a)-8(c) respectively present the results obtained from microlenses with diameter of 1000 μm, 500 μm, 200 μm. The three figures clearly demonstrate the following: (1) The maximum sag height in each case approached 50% of the microlens diameter. Thus, microlenses with a larger diameter presented a higher sag height than did microlenses with a smaller diameter. The maximum height of the 1000 μm microlens was 500 μm, whereas the maximum height of 200 μm microlens was 100 μm; (2) Regardless of the microlens diameter, a thicker membrane resulted in less deformation. For example, microlenses with a membrane 122-μm thick presented a lower sag height than did those with membranes with thickness of 35 μm; (3) In all cases, thinner membranes presented a higher curve slope indicating a faster response to pressure. Figure 9 presents a comparison of three microlenses of various diameter but the same thickness. Clearly, a microlens with a larger diameter was more responsive to changes in pressure, resulting in more pronounced deformation. Currently the PDMS membrane thickness and the level of PDMS deformation is highly related to the design of mold insert, material of mold insert, and precision of the machining, hence more research with industry-level machines has to be conducted to increase the reproducibility. Based on the diameter of the microlens, the measured sag height, and the optical properties (index of refractive is 1.4), we used the equations in  to convert the data in Fig. 8 to render the focal length of the microlens as a function of lens diameter and pressure, as shown in Fig. 10. A microlens with diameter of 1000 μm has a maximum focal length of approximately 11 mm, corresponding to pressure of 5 kpa in Fig. 8(a). In all three cases, an increase in pressure resulted in a decrease in focal length. The focal lengths in Figs. 8-10 were estimated from the measured sag height and curvature. We then used the system in Fig. 6 to measure the actual focal length of each MLA (1mm diameter and various sag heights). Measurements were obtained from ten microlenses on a single substrate. As shown in Table 1, the difference in focal length between the estimates and measured values was less than 3%.
5.2 Magnification of tiny dots and enhancement of fluorescence signals using microlens
Figure 11 shows three PDMS MLAs with different sag heights and magnifications, all of which were fabricated from the same hybrid microfluidic chip. Changing the pressure inside the microchannel altered the degree to which the PDMS membrane on the hybrid microfluidic chip was deformed, resulting in PDMS MLAs with different sag heights. We used a paper with tiny black dots (diameter is 3.84μm) as a background to illustrate the difference in optical performance between the three MLAs. Clearly, the MLAs with the highest sag height (400 μm) in Fig. 11(c) produced the greatest magnification (diameter is 6.25μm, magnification is 1.62) whereas the MLAs with the smallest sag height (150 μm) in Fig. 11(a) produced the least magnification (diameter is 4.86μm, magnification is 1.25).
Figure 12 presents the results of fluorescence experiments. Figures 12(a) and 12(b) respectively present images of fluorescence in the microchannel captured using the microlens with diameter of 1 mm. The sag height in Fig. 12(a) is 235 μm whereas the sag height in Fig. 12(b) is 459 μm, corresponding to numerical aperture of 1.24 in Fig. 12(a) and 1.6 in Fig. 12(b). The images were captured using a fluorescence microscope and then analyzed to determine the intensity of the fluorescence signal. Figure 12(c) presents the analysis results (the lines shown in the Fig. 12(a) and 12(b) are the locations for analysis). The fluorescence signal from the microlens is clearly stronger than the direct signal from the microchannel (1000 a.u.). As indicated by the two peaks in Fig. 11(c), a microlens with a higher sag height of 459 μm greatly increased fluorescence intensity to 3500 a.u., whereas the microlens with a sag height of 235 μm increased fluorescence intensity to 2600.
5.3 Uniformity of MLAs
After fabricating MLAs on the PDMS substrate, the MLAs was fixed on the optical system shown in the Fig. 6(b). The x-y table was adjusted to ensure the imaging had the smallest circles on the CCD camera, meaning the distance between the MLAs and the CCD was the focal length. Figure 13(a) shows the captured image from the CCD, which had multiple dots due to the imaging of the MLAs. The captured image was imported into Matlab for intensity analysis, the results of which are presented in Fig. 13(b). The number next to each red dot in Fig. 13(a) indicates the maximum intensity of each peak, which clearly demonstrates that this manufacturing method could fabricate MLAs of high uniformity.
This paper reports a novel, straightforward, and cost-efficient method for the manufacture of MLAs in various dimensions. The proposed method involves micromilling and bonding to produce a hybrid microfluidic chip, followed by UV adhesive casting and PDMS casting. To make this manufacturing method closer to the commercialization of MLAs, the final step of PDMS casting could be replaced with electroplating metal mold inserts for mass production. In this study, we manufactured MLAs with diameters of 1000 μm, 500 μm, and 200 μm for characterization tests. Multiple experiments were conducted, which led to the following conclusions: (1) the specific sag height or focal length of MLAs can be achieved by carefully designing the diameter of the micro pillar structure, membrane thickness of the MLAs, and controlling the pressure inside the microchannel; (2) the resulting MLAs can be used to magnify tiny objects or help concentrate fluorescence signals from the microchannel to improve detection sensitivity; (3) an optical system was built to investigate the uniformity of the fabricated MLAs, and the result clearly showed that this proposed method can manufacture uniform MLAs; (4) this method can be potentially used for manufacture large-area MLAs with high density at a lower cost and shorter manufacturing period.
Ministry of Science and Technology (MOST 105-2221-E-011-061).
We appreciate Prof. Hung-Lin Hsieh from Mechanical Engineering Department of National Taiwan University of Science and Technology to help setup an optical system to measure the uniformity of MLAs.
References and links
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14. W. Yu and X. Yuan, “UV induced controllable volume growth in hybrid sol-gel glass for fabrication of a refractive microlens by use of a grayscale mask,” Opt. Express 11(18), 2253–2258 (2003). [CrossRef] [PubMed]
15. M. H. Wu, C. Park, and G. M. Whitesides, “Fabrication of arrays of microlenses with controlled profiles using gray-scale microlens projection photolithography,” Langmuir 18(24), 9312–9318 (2002). [CrossRef]
16. D. L. MacFarlane, V. Narayan, J. A. Tatum, W. R. Cox, T. Chen, and D. J. Hayes, “Microjet fabrication of microlens arrays,” IEEE Photonics Technol. Lett. 6(9), 1112–1114 (1994). [CrossRef]
17. S. D. Moon, N. Lee, and S. Kang, “Fabrication of a microlens array using micro-compression molding with an electroformed mold insert,” J. Micromech. Microeng. 13(1), 98–103 (2002). [CrossRef]
18. C. Y. Chang, S. Y. Yang, M. S. Wu, L. T. Jiang, and L. A. Wang, “A novel method for fabrication of plastic microlens array with aperture stops for projection photolithography,” Jpn. J. Appl. Phys. 46(5A), 2932–2935 (2007). [CrossRef]
19. S. M. Kuo and C. H. Lin, “The fabrication of non-spherical microlens arrays utilizing a novel SU-8 stamping method,” J. Micromech. Microeng. 18(12), 125012 (2008). [CrossRef]
20. H. Sun, X. Wang, Y. Xiong, G. Liu, and K. Wang, “Fabrication of microlens based on overplating in electroforming,” J. Micromech. Microeng. 26(5), 055007 (2016). [CrossRef]
21. C. Jiang, X. Li, H. Tian, C. Wang, J. Shao, Y. Ding, and L. Wang, “Lateral flow through a parallel gap driven by surface hydrophilicity and liquid edge pinning for creating microlens array,” ACS Appl. Mater. Interfaces 6(21), 18450–18456 (2014). [CrossRef] [PubMed]
22. X. Li, H. Tian, Y. Ding, J. Shao, and Y. Wei, “Electrically templated dewetting of a UV-curable prepolymer film for the fabrication of a concave microlens array with well-defined curvature,” ACS Appl. Mater. Interfaces 5(20), 9975–9982 (2013). [CrossRef] [PubMed]
24. J. Chen, W. Wang, J. Fang, and K. Varahramyan, “Variable-focusing microlens with microfluidic chip,” J. Micromech. Microeng. 14(5), 675–680 (2004). [CrossRef]
27. S. W. Lee and S. S. Lee, “Focal tunable liquid lens integrated with an electromagnetic actuator,” Appl. Phys. Lett. 90(12), 121129 (2007). [CrossRef]
28. D. J. Guckenberger, T. E. de Groot, A. M. Wan, D. J. Beebe, and E. W. Young, “Micromilling: a method for ultra-rapid prototyping of plastic microfluidic devices,” Lab Chip 15(11), 2364–2378 (2015). [CrossRef] [PubMed]
29. K. Kim, S. Park, J. B. Lee, H. Manohara, Y. Desta, M. Murphy, and C. H. Ahn, “Rapid replication of polymeric and metallic high aspect ratio microstructures using PDMS and LIGA technology,” Microsyst. Technol. 9(1–2), 5–10 (2002). [CrossRef]
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Roland Emmerich is finally getting around to the Independence Day sequel he’s been talking about since forever. Today, 20th Century Fox announced a July 3rd, 2015 release date for Independence Day 2. Unfortunately, Will Smith is unlikely to participate in this one (so much for getting an encore of “welcome to Earf!”), but Bill Pullman is on board to reprise his role as the now-ex POTUS.
The plot takes place twenty years after the events of the first film, and focuses on an invasion of alien reinforcements (maybe this time they’ll remember to update their computer virus protection?). Also, the film will have a cliffhanger that leads into a second sequel.
I have a feeling something bad is going to happen to the White House again. Unless, in the post-ID world, the president resides in an underground bunker. Either way, we can’t wait!

domain: entertainment


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The fifth of March marked our second wedding anniversary. And I figured Alan Dart’s Bridal Bunnies would be the perfect project to celebrate a Spring wedding anniversary 😀
Here’s a pic of the work in progress:
The chubby bunny bride:
And the wide-hipped bunny groom :P:
For the bride’s veil, I didn’t have the recommended yarn and, as you can see, it came out quite weird. I’m planning on replacing it with a netted fabric or something. I also decided to skip the instructions for the bridal bouquet (so what’s new! ;)) and instead made a bouquet of tiny ribbon roses and ready made blue stamens 😀
It took me around 12 days to make these two. And what does my very own Mister Bunny have to say about our anniversary project? “Not your best work,” he says, promptly pointing out all the areas that could use a little improvement.
Ah, men! Pattern: Alan Dart’s Bridal Bunnies

domain: artistic


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Medannex are urgently seeking partners to help expedite the development of a novel antibody (MDX-124) which may help in the fight against COVID-19.
MDX-124 targets annexin-A1, a key component of the immune system. Annexin-A1 facilitates multiple steps in the lifecycle of viruses, together with their incorporation and proliferation in human cells – which is of particular importance in the current pandemic. By blocking annexin-A1, our antibody could disrupt the infectivity and transmission of SARS-CoV-2 and lessen the impact of the associated cytokine storm.
Medannex are in need of a non-insulin dependent MCF-7 breast cancer cell line.
Download a one-page summary on the role of MDX-124 in this setting below.
Medannex is looking for ‘plug and play’ in vitro assays for testing our humanised antibody to annexin-A1 in the context of COVID-19 (possibly followed by in vivo).
If you think you may be able to help Medannex, contact us through the button below or send an e-mail to firstname.lastname@example.org.


text:
By Sadiq Umar, Abuja.
President Muhammadu Buhari has ordered the immediate release of $21 million to the Multi-National Joint Task Force’s (MNJTF), as part of his determination to confront the Boko Haram menace headlong.
The amount which is to be released within one week is part of Nigeria’s $100 million pledge at the extra-ordinary summit of the Lake Chad Basin Commission and Benin held in Abuja last week.
Buhari who disclosed this at the 25th African Union Summit in Johannesburg, where he chaired the Peace and Security Committee (PSC) at the weekend also called on African leaders to put the interest of the citizens above personal interest.
The President said the conflict in Sudan and Burundi is at the centre of agenda of the AU meeting, pointing out that the matter has to be put in context.
Buhari noted that the crisis in those countries was largely owing to internal bickering among its leaders.
He commended the cooperation of Nigeria’s neighbours –Chad and Cameroon in tackling Boko Haram.
“The boko haram insurgency has extended it’s reached to Nigeria’s neighbours but is not necessarily limited to these immediate countries as terrorism is a global phenomenon with linkages across the globe,” he said.
Given this dimension of global terror it requires to act according in brotherhood and partnership to fight our common goals against agents of evil.
“I’m pleased to note that Cameroon, Chad, Niger, are demonstrating this secret, they are fighting alongside Nigeria under the umbrella of Multinational Joint Task Force to defeat Boko Haram.
“In this regard, the member countries Lake Chad Basin Commission and Benin, met recently where far reaching decisions were taken to immediately put into operations the Multinational Joint Task Force.
“To this end, the summit approved the immediate provision of $30 million for the Multinational Joint Task Force.
“Consequently out of the pledge of $100 million which Nigeria made to Multinational Joint Task Force, I have directed that $21 million be released within the next one week”.
President Buhari, recalled that the AU had in 2013 during the 50th anniversary celebration of the union, African leaders had committed themselves to the objective of silencing the local guns in Africa by 2020.
“With just five years remaining, the prospect of realizing this objectives looks doubtful within individual countries and the continent as a whole,” Buhari said.
“In particular, we are witnesses to the rampant destruction of homes, roads, communications lines, vital infrastructures and displacement of persons not to mention terrible loss of lives.
“This is true I must add of the north east of Nigeria where we are dealing with the scourge of boko haram”.
“Today’s meeting of PSC, which is to discuss the situations of South Sudan and Burundi, requires us to put these situations in proper context. The people of these countries are suffering while their political leaders are bickering among themselves.
“I believe that is incumbent upon us as leaders to always place the interest of our countries above narrow and personal interest.
“It is therefore my expectations that at the end of this summit, the PSC will come out with a united message to call on all parties to act in the interest of their people and the entire continent.

domain: politics


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In the first part of this series on shallow running back sleepers, we took a look at Jonathan Stewart and why I think he has the potential to be a low end RB1, despite being drafted as a RB3. This time around I want to take a look at a guy being drafted as an RB2 that I can see finishing in the top 10 RB as well. This player is Lamar Miller.
In the 2015 NFL Draft, the Dolphins took Boise State RB Jay Ajayi in the fifth round. Ajayi fell in the draft because of several executives backing off of him after their medical staffs evaluated his surgically repaired knee. The injury(torn ACL) was in 2011, and he played three healthy seasons after that surgery. But something about the repaired knee and his heavy college workload caused teams to back off and allowed Miami to scoop him up in the fifth round.
The reason I am talking about Ajayi is because I think it is important to handcuff Lamar Miller with Ajayi, just as the Dolphins have. I think in the long run of this season, Ajayi only has the potential to steal 3rd down plays from Miller and not much more. But I do think it is important to handcuff him.
That being said, there are not a ton of carries to be spread around, the speedy Miller never carried the ball more than 19 times last year and under Philbin the Dolphins have the 3rd lowest carries in the league. However, he has said:
“I would tell you I’ve never been in a meeting where I’ve said to (offensive coordinator) Bill (Lazor) or (running backs coach) Jeff Nixon or the offensive line coaches have said ‘Lamar can’t carry the ball 20 times a game. He can’t do it,'” Philbin told ESPN.com. “I’ve never heard that. That’s never come out of my mouth.”
So if this means Miller can average around 20 carries a game if he preforms well (like his 5.1 YPC last year, 2nd only to Justin Forsett), he should finish in the top 10 RB. Among the top 30 RBs in 2014, Lamar Miller ranked 3rd in pound for pound speed (Speed Score), only behind fellow shallow sleeper Jonathan Stewart and the best handcuff in football, Knile Davis.
The Dolphins offense is improved, and the offensive line is young but healthy. LT Branden Albert’s season ended in week 10 last year, and after he got hurt the line was shuffled and out of order. With Albert back healthy, 2nd year RT Ja’Wuan James goes back to his preferred position and has a year under his belt now. Pro Bowl Center Mike Pouncey gets to go back to C after shifting from C to G mid season last year. If the Dolphins end up signing Evan Mathis, I would like Miller even more, as Guard is the weak spot on the Dolphins OL. However even if they don’t, they hope rookie Jamil Douglas can help out along with Billy Turner (2nd year) and Dallas Thomas (3rd year).
With the O-line of some concern, Miller is reported to be bigger this year, and came into camp adding 15 pounds of muscle to boost his durability. Miller, 24, is in the final year of his rookie contract and has a pretty big incentive to preform whether he stays with the dolphins or not. I have him as my RB 12, and would be ecstatic to get him in the 2nd round as my teams RB1 if I decide to go WR or Gronk in Round 1.


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Tuesday, September 7, 2010
Wild Top Tuner 2010 Chevy Camaro with 1400hp
One of the craziest 2010 Chevrolet Camaros I have seen as of yet. Built by a team of custom car builders that know how to build some beautiful works of auto art. Their crew is known as "Top Tuner" and they hail from Canada. This monster Camaro is owned by Serge Leger, the paint specialist of the crew. It boasts 1400 horsepower with a turbocharged GM 6.0L LSX V8 powerplant. Wheels are custom STRUT 22x10-inch front with 3-inch lip & 24x15-inch rear with 7-inch lip. Plenty of carbon fiber throughout the body and chassis to keep the weight down. Superb photos taken by the designer and artwork specialist of the crew, Matthew Law. We will also feature their prior builds in the near future.


I created a little Framer module that makes it easy to overlay your prototype with a grid. I believe prototyping can play a role throughout the entire design process and having a feature like a grid could help with experimenting from the start.
Download it over here: https://github.com/nilshoenson/Framer-Grid
Please let me know what you think! :)
Interesting approach. I'm doing something very similar but vertical and horizontal on 8px units across various screen densities.
It's a bit more complicated but your version is great!
Thanks Jordan! Excited to see your approach.
I'm still working out how I want to draw lines. 1px or 2px... And how to incorporate fluidity as well.
Nice work man Nils Hoenson


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Tetris in DOS form with only four columns of movement available.
This is Joe Larson, the author of the game. No seriously. It's me.
I wanted to correct something in the previous review. The game isn't DOS. It's windows. If you try to run it in DOS... well, I'm not sure what will happen. Either way this is compiled for windows. It's just a console app, which I guess confuses some folks.
That review also failed to mention the dangerously addictive nature of the game. Since lines clear so frequently the rewards come quickly. It's not unusual to get 100 lines cleared in a 5 minute game... if you make it that far.
Another thing to note is that the only sound in the game is the default "bing" when you clear a line. Personally I like to change what sound plays in control panel so that I don't get bored with it.
So, yeah. Glad you like the game, and it looks like you've got the most up to date version, so that's good. It's got a plug for my site, Cymon's Games, where I've got a number of other games, not all by me, and not all this good... or bad.
In another remake of Tetris, you have to... stack blocks. Really, if it has to be explained to you at this point, then you should stop trying to like games and move on to something else. Tetris is Tetris, end of story.
This version happens to have been implemented in DOS, is open source and has limited movement available. Yes, there are only four vertical columns of movement. This automatically makes the game trickier, but also causes the humorous side-effect of when you get a straight piece, turn it sideways and it creates a line all by itself and as a result - promptly vanishes.
There is little else to differentiate this from any other game of the same ilk. Its levels continue upward with a different colour for each screen. Your score is also saved. Apart from that, its really just another standard Tetris variation. Nothing extremely exciting.

domain: game


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iHOLA! ……….. Visit New Places and Make New Friends! With Pete the Pilot and Panchito! WOW!
Published by PoliglotKidz Press
ISBN 978-0-9911324-0-9 Soft Cover Edition
At the request of the author, Judy Martialay I received said paperback, but larger than usual paperback; it was also sent to me at no charge for my honest opinion.
It’s books like these I enjoy the most. Maybe I’m a kid at heart, and at the same time thriving for more education no matter how old I get, and in this day and age it’s a good thing to learn a second language as you go out in the world, and what better language to start with than Spanish. So let’s get down to the fun stuff. May I also add here first that there’s a audio version at: http://polyglotkidz.com …
This book is for the teachings of children who want to learn. Possible age range 6-10, and their parents whether they know Spanish or not. The purpose for the book is to ease into the learning of Spanish and how fun it could actually be. With the audio version parents and children could follow along in making it super simple by hearing how the word is pronounced and you can start, stop as many times as you like until you got it… is that cool or what!!!! It also contains advice for parents on the “Parents Page”, on how to use the book as well as links to interesting articles on language learning for children. There’s even a downloadable game to play as a review when you finish the book.
Talk about making homeschooling can give parents and children an experience in language learning which can be followed up with long-term language programs designed for homeschool use when they become much older. They’ve got a step up on the game already!
MY THOUGHTS and OPINION
As you all know I have four children and eleven grand-children and one great grandson. I know what a crew, huh? Well, I worry about their education and what they get at school, but this book is something parents can teach them at home and it’s something fun and to even make a game out of it. Children get to meet Pete the Pilot , who takes them on an imaginary trip to Mexico. During the trip, they learn some basic Spanish. Their are so many Spanish speaking children at my grandchildren’s school… heck, it was that way when my children were growing up and they would come home speaking some Spanish phrases and I was amazed… and answered back… WHAT??? Children bring their Spanish back home with them to practice with friends and family in the activities section of this book. In the culture corner, they learn more about life in Mexico and have more opportunities to practice Spanish. Finally, they follow simple directions in the craft section to make a traditional Mexican mask…. FUNNNNNN!!!!!!
This book was also highly entertaining as well as educational. The author definitely has a way with words to hold your interest, and I hated to put the book down when I had to stop for a moment for the real world’s chores.
The pictures in the book only added to the indebtedness of the subject. Nothing elaborate to take away from the book itself. They were a perfect addition. Christmas would be a great way to open up a new world for your child or relative/friend. Stocking stuffer? Definitely. Birthday present? Of course. Just because you care? Most assuredly. This holiday season pick up a copy of HOLA “Let’s Learn Spanish”, and give it to Santa. He knows a lot of people, and children that could use a break from the real world, and put a smile on everyone’s face with fun and learning.
The book is now available in print for $15.22 and Kindle for $7.99 on Amazon, and in print on B&N online.
Now “HEY IT’S CHRISTMAS” and the author would like me to hold a GiveAway right here and now. Woo Hoo… so just enter below and GOOD LUCK TO YOU ALL!
BUENA SUERTE (GOOD LUCK)
*Disclaimer: Opinion in this Post is 100% my own and no monetary compensation was given. I received a product sample in order to facilitate my honest review.

domain: library