text:
Liver Disease & Liver Transplant
When damage from liver disease is so advanced that it cannot be reversed and the patient is in danger of liver failure, a liver transplant is necessary. Most liver transplants are performed because of liver failure caused by hepatitis C (HCV).
Unfortunately, the number of patients who need liver transplants is greater than the number of available organs. Any candidate for a liver transplant must undergo extensive testing to determine if a transplant is likely to succeed and to identify potential problems. These evaluations usually are performed at an organ transplant center.
Liver transplant requires a team of health care professionals to perform the pre-surgery evaluation, the surgery, and the post-surgical care. Liver transplant teams often consist of a surgeon, several physicians with differing specialties, several nurses, a mental health professional, a dietician, a physical therapist, and a pharmacist.
The transplant team evaluates each patient who needs a new liver and assigns a score that represents the severity of the patient's condition. Patients are then placed on a waiting list to receive a donated liver.
Donated livers come from people who agree to donate their organs when they die or from living family members who agree to give a portion of their liver to a loved one in need (called live-donor liver transplant). Because a healthy liver can regenerate itself, a transplanted liver from a live donor can regenerate in about 6-8 weeks.
Most transplant patients are hospitalized for up to 3 weeks. Because a new liver is foreign tissue in the body, patients must take medications that suppress the immune system for the rest of their lives to prevent rejection.
Six months to 1 year after transplant surgery, many patients are able to return to a normal or near-normal lifestyle. Seventy-five percent of patients who receive liver transplants are still alive 5 years after their surgery. The five-year survival rate for living donor transplants is even higher.

domain: biology


text:
Vancouver, Canada / November 4, 2020 / Perk Labs Inc. (CSE:PERK / OTCQB:PKLBF / FKT:PKLB) (“Perk” or the “Company”) the parent company of Perk Hero, the mobile commerce platform with cashback rewards on e-gift cards and curated goods, announced today that it has amended its stock option plan and restricted share unit plan (the “Amended Plans”) to increase the number of common shares that may be reserved for issuance under the Plans from 10% to 15% of the Company’s issued and outstanding common shares. The Company also amended its stock option plan to reduce the minimum exercise price from CAD $0.10 to $0.05.
The amendments to the Plans and grants of restricted share units or stock options under the Amended Plans are subject to disinterested shareholder approval which will be sought at the Company’s next annual and special meeting of shareholders.
Several members of Perk’s Management and Board have made a decision to be partially compensated in RSUs in lieu of cash compensation moving forward as part of ongoing efforts to prioritize Company’s business development initiatives that will drive shareholder value.
About Perk Labs Inc.
Perk Labs Inc. is the owner of Perk Hero, a mobile commerce platform with cashback rewards on e-gift cards and curated goods. For more information about Perk Labs, please visit www.perklabs.io
For more information contact:
Perk Labs Inc.
Neither the Canadian Securities Exchange nor its Regulation Services Provider (as that term is defined in the policies of the Canadian Securities Exchange) accepts responsibility for the adequacy or accuracy of this release.
This press release contains forward-looking information or forward-looking statements (collectively “forward-looking information”) within the meaning of applicable securities laws. Forward-looking information is typically identified by words such as: “may”, “believe”, “thinks”, “expect”, “exploring”, “expand”, “could”, “anticipate”, “intend”, “estimate”, “plan”, “pursue”, “potentially”, “projected”, “should”, “will” and similar expressions, or are those, which, by their nature, refer to future events. These forward-looking statements, which involve risks and uncertainties, relate to, among other things, the discussion of the Company’s business strategies and its expectations concerning future operations. Although the Company considers these forward-looking statements to be reasonable based on information currently available to it, they may prove to be incorrect, and the forward-looking statements in this release are subject to numerous risks, uncertainties and other factors that may cause future results to differ materially from those expressed or implied in such forward-looking statements. The Company cautions investors that any forward-looking information provided by the Company is not a guarantee of future results or performance, and that actual results may differ materially from those in forward-looking statements. Undue reliance should not be placed on such forward-looking information, as there can be no assurance that the plans, intentions or expectations upon which they are based will occur.

domain: economics


text:
The Oluwo of Iwoland, Oba Abdulrasheed Akanbi, has reacted to the news of him being suspended for six months by the Osun State Traditional Rulers’ Council.
Oba (Dr) Abdulrasheed Adewale Akanbi Telu is the one and only Oluwo of Iwoland.
He was never suspended as Oluwo of Iwoland.
Osun State Traditional Council has only recommended his suspension from the council meetings and activities for six months on the guise that his conduct (been too flashy,stylish, human rights defender and swagging) and that is even subject to Governors approval
This clarification is important for public notice!
He also shared a post on his social media page stating that the suspension is ”just from the monthly council meeting which is subject to the approval of the state government. He wrote;
Investigation: Oluwo Didn’t Punch Another King, Witnesses Reveal
The investigation into the alleged punching of another king by the Oluwo of Iwoland, HIM Oba (Dr.) Abdulrosheed Adewale Akanbi, was put to rest today by the Osun State Council of Traditional Rulers as the primary witnesses including the AIG zone II and government officials attested there was no punching except altercation.
The emergency meeting was to investigate through witnesses presence at the zone II where peaceful meeting was held to resolve issues relating to incessant land selling in Iwoland. After the witnesses accounts at the traditional council meeting today, it was established there was no punch than altercation.
It is amazing he was alleged his conducts against some monarchs are not in tune with them. We came to address allegation of beating another King. How does my conducts affect another monarch? Must I toe the same path with other monarchs?
The pronouncement itself is subject to the approval of the state govrnment. The council has no constitutional right suspend another king from its monthly meeting unless approve by the state government.
Oluwo was never suspended. The suspension reported in the media is just from the monthly council meeting which is subject to the approval of the state government.
All Osun State monarchs were invited to address the allegation that Oluwo punched another Oba. The AIG and the government officials presence came to the meeting as witnesses and gave account that I didn’t beat any Oba. Oluwo was vindicated. Of surprised to us was that another issue raised against me that his conduct against some Obas were not friendly that could warrant recommendation for suspension from the monthly meeting .

domain: law


text:
Textiles | On 19th Jan 2017
Excise duty on man-made fibres should be reduced to bring it on par...
Apparel/Garments | On 19th Jan 2017
Spanish apparel brand Mango has unveiled an adapted version of its...
Apparel/Garments | On 18th Jan 2017
The Government of India is looking at allowing 100 per cent foreign...
'Hugo Boss works with carefully selected sourcing partners'
Sanjay Desai & Ashish Mulani
Digital textile printing will be the technology of the future
Bridalwear is not about reds and whites anymore
Swerea IVF AB
Marten Alkhagen, Senior Scientist - Nonwoven and Technical Textiles of...
Technical Absorbents Ltd
Mark Paterson, R&D manager of Technical Absorbents Ltd talks about Super...
The Indian market has huge potential in technical textiles, and by far,...
"Now we can see the Russian trend in international fashion. And Russian...
Label Ritu Kumar
‘Classics will return’ "There are a lot of people wearing western clothes ...
"We should not compare India and the West. There are things we do that...
Textiles | On 18th Jan 2017

domain: news


text:
The UK Prime Minister Theresa May is announcing how the government intends to use a long-term commitment to research and innovation to get the economy firing on all cylinders.
- substantial real terms increases in government investment worth £2 billion per year by 2020 for research and development, to ensure British business remains at the cutting edge of scientific and technological discovery
- a new Industrial Strategy Challenge Fund to back priority technologies – such as robotics and biotechnology – where the UK has the potential to turn strengths in research into a global industrial and commercial lead
- a review of current R&D tax incentives to ensure the global competitiveness of the UK as a home for scientists, innovators and tech investors
The new Industrial Strategy Challenge Fund, overseen by UK Research and Innovation, will back projects covering a number of priority technologies and help Britain build on existing strengths in research and development.
Despite its strengths in science, Britain has until now been relatively weak on commercialisation, meaning that all too often ideas developed in this country end up being commercialised elsewhere.
Government will consult on how the fund can best support emerging fields such as robotics and artificial intelligence, industrial biotechnology and medical technology, satellites, advanced materials manufacturing and other areas where the UK has a proven scientific strength and there is a significant economic opportunity for commercialisation.
More information http://bit.ly/2gBDZcl


Piarulli was selected for her research program, “From Atomic Nuclei to Infinite Nucleonic Matter within Chiral Dynamics,” which falls under the Office of Science’s Nuclear Physics program office. The award is meant to support individual research programs of outstanding scientists early in their careers.
“My research aims to develop a clear and coherent picture in which microscopic models
accurately describe atomic nuclei while simultaneously predicting properties of infinite matter,” Piarulli said. “It will make use of state-of-the-art computational techniques and high-performance computing to broaden the applicability of the Quantum Monte Carlo methods.”
Piarulli works closely with collaborator Saori Pastore, assistant professor of physics, and members of the university’s Quantum Monte Carlo Group. She is also part of the McDonnell Center for the Space Sciences’ Particle and Nuclear Physics, Cosmology and Gravitation research group.
“Maintaining our nation’s braintrust of world-class scientists and researchers is one of DOE’s top priorities — and that means we need to give them the resources they need to succeed early on in their careers,” said Secretary of Energy Jennifer M. Granholm in a statement. “These awardees show exceptional potential to help us tackle America’s toughest challenges and secure our economic competitiveness for decades to come.” Researchers are expected to receive at least $150,000 annually for five years to cover summer salary and research expenses.


text:
Living SustainablyIssue 10 - Feb 2009
NSW households can save money, water, energy and greenhouse gas emissions by applying for rebates under the $100 million NSW Climate Change Fund Residential rebate program.
The $35 Fridge Buyback rebate is paid when collection involves six or less stairs. Collection is free, but no rebate is paid, where collection involves between 6-20 stairs.
Under the program, refrigerant gases are collected and destroyed using trained staff licensed under the Australian Refrigeration Council’s requirements.
The $150 rebate for 4.5 star washing machines is available for purchases from 1 August 2008.
or more information
- visit the DECC website
- call the Environment Line on 1300 361 967


text:
MYTH BUSTERS & FACTS @ Reno City Hall June 8th 2016. Just Label it already! City asked to support a motion to label genetically engineered foods in the state of Nevada. Help support Label GMO Nevada.
Outrageous myths shared by Nevada Department of Agriculture, Future Farmers of America, Dairy Farmers Board Rep and Big Box Chain Store rep:
- GMO’s are tested by scientists, over 3000 studies. (truth, over 3k Monsanto scientists have studied their own product and submitted to our FDA who approved without question)
- It is too expensive for us to re label our food products as genetically engineered and would drive up the cost of foods for poor citizens. (fact, the FDA just released last month, May 2016 that all food labels are required to re-lable all food products to bold the sugar and calorie numbers on the food panel. Every food producer in the country already has to re-lable their products or have HUGE fines from the government)
- GMO’s allow farmers to grow more food to feed the poorest countries in the world. (fact: GMO’s are used for ethanol and processed junk foods and are not nutritious)
- Future Farmers of America past president said “You should trust the hands that feed you.” (all i have to say is, children of the corn is a scary movie geeeez) see below.
Please do your part. Call our city representation and ask them to do the right thing and require labeling of GMO’s in our home state.
Mayor and Council:
Hillary Schieve <email@example.com>
Neoma Jardon <firstname.lastname@example.org> ****our Ward 5 council person****
Jenny Brekhus <email@example.com>
Oscar Delgado <firstname.lastname@example.org>
Paul McKenzie <email@example.com>
Our Ward 5 Liaison Barbara DiCianno 775-334-3112 firstname.lastname@example.org
Calli Wilsey (775) 689-8459 mailto:email@example.com
Cynthia Esparza-Trigueros 775-677-6881; <firstname.lastname@example.org>“You cant call GMO’s natural. Injecting the DNA from a crab into the corn plant is NOT natural evolution.” Sandy Rowley

domain: food


Tories look ahead to a comeback
Political parties always try to sound upbeat coming out of convention but Nova Scotia’s Progressive Conservatives sounded like they meant it in Halifax last weekend. As party president Rob Batherson pointed out, this annual general meeting felt a lot different from 1994, the convention that followed the ascension of a Liberal majority government under John Savage.
At that time the Tories were beaten, humiliated, even disgraced. Few could have hoped that they’d form another majority government before the decade was out, but that’s what happened.
There are parallels. The Savage Liberals carried expectations of social progressivism but within months their agenda has been hijacked by near panic over the horrendous state of the province’s finances. The medicine was unpopular. The fiscal situation is not as dire for the new NDP government but the task of a progressive party selling fiscal restraint is no less daunting.
The PCs know it will be a long four years for the government. The NDP’s stumbles out of the gate, reneging on major election promises and embarrassing itself with stories of excessive expense spending, can only accelerate the fading of the bloom. It doesn’t help the PC cause that in second place on the list of expense abuses flagged last week by the auditor general is a sitting Tory, Yarmouth’s Richard Hurlburt ($7,995 for that generator plus $3,078 for the purchase and installation of a 40-inch LCD television).
After losing the government to the NDP and Official Opposition status to the Liberals last June, the third-place Tories found some comfort in the October byelections. They lost Antigonish as expected but managed to hold Inverness against a determined Liberal challenge. The Liberals remain one up on them in the legislature but Liberal Leader Stephen McNeil hasn’t set the province on fire, and come October the Tories will have a new (or at least newly confirmed) leader of their own.
Therein lies the party’s toughest question as it plots recovery. Does it go back to its rural roots as Cape Breton West MLA Alfie MacLeod advises and try to win shore up its base or does it set its sights on urban ridings? This urban-rural tension was there in the last leadership race, won by the future fiddling premier, Mabou’s Rodney MacDonald, and it promises to be a dominant dynamic again.
Though no one has announced for the job, it’s widely speculated that the list is likely to include current interim Leader Karen Casey; Credit Union Atlantic president Jamie Baillie, a former chief of staff to the premier when John Hamm held that post; former cabinet minister Chris d’Entremont, one of nine surviving Tory MLAs; and retired insurance executive Bill Black, who lost the leadership race to MacDonald in 2006.
Among the best reasons for Tory optimism is that formidable candidates will likely vie to lead them out of the basement. This is not a job that nobody wants.


text:
Foster Glorioso (@fosterglorioso)
New York City
A boutique hair salon
Location: 5 east 19st NY, NY 10003
56266 Total post views
Exploring Malta: An Expat's Guide (@exploringmalta)
Sand, sea and adventure
Will Adams (@willdotadams)
Freelance illustrator & animator
Jacob Eisinger (@yippiehey)
Designer/Illustrator/Catlover 3D Illustration & Artdirection Based in Hamburg
Maker based in Oslo, Norway.
Luke Grant-Muller (@lukegrantmuller)
Creative Director. I make things.
caitlin sullivan (@cathblast)
Bie Van Laer (@vonblair)
Antwerp - Belgium
exploring the digital worlds
on a adventure with cube
Human being exploring the limits of his existence. Brain enthusiast. Geeky Poet with the eye of a Photographer. Thinker. Consciousness explorer rather. Into insane stuff. Likes Vedic Astrology. Computational Fluid Dynamicist. Living the kundalini life. Meditation. Chess. All things non-dual and energy and consciousness. Period. Changing the world, one breath at a time. Inhale. Pause. Exhale. Pause.
Studied fine art, graphic design... Working as a documentary researcher & production coordinator.
Love reading, yoga, friends, large cities and more.
Living in Canada.
gregor zakelj (@gregorzakelj)
Designer at VBG / Visual Brain Gravity design studio. Founder of Dimension Two Longboards. Alive and lost.
International tattoo gallery and artist, studio and event directory. All the tattoos shown here are custom pieces, do not copy without permission.
Tom Moore (@tommooreillustration)
All Things Creative (@brianmichaeljones)
I am who I appear to be to those who it appears as me, but I am no more me then I am him to them.
All works currently exclusive to Ello.
Andee Cris (@ataraxiaa)
As above, so below.
Neomaterialist poet, novelist and consumer culture researcher; crow and otter; lone ranger from Portland, OR, living in St. John's, Newfoundland.
Chris Bathgate (@chrisbathgate)
Machinist Metal Sculptor. Full time artist working in Baltimore.
Matt Harvey (@75centralphotography)
I do photography and coding and other nondescript things.
Anna Marie (@rogueminx)
Indie clothing designer based in Portland, Oregon. Causing trouble and proving ethical / cruelty free / eco friendly fashion can look really fucking rad.
Ed Buziak (@ellonikon)
Post photos taken with Nikon / Nikkor equipment tagged with @ellonikon to be considered for sharing here. Preference will be given to strong images, preferably with caption information, showing what Nikon cameras and lenses can achieve, and how you did it. I've used mainly Nikon equipment for around 50 years and was a former Nikon UK Advisory Board consultant. Edited by Ed Buziak at @edbuzz who also leads the @postalhistory community on Ello.
Ed Buziak (@postalhistory)
Regular postings of old envelopes and postcards exploring aspects of stamps, countries, transport and people under the world-wide cover of 'postal history'. Mention @postalhistory and share your old letters, their anecdotes and memories. Compiled by @edbuzz who also leads the @ellonikon community.
Yngvar Larsen (@yngvarlarsen)
Then : Oslo, Norway
Last : Davie, FL, USA
Now : Brussel, Belgium
Media: Photography, sculpture, installations
Lead: Tracy Van Santana @tvansantana (@ellowrites)
Welcome to the Ello writing community! Mention @ellowrites to be considered for reposting. Happy writing!
See writer spotlights under #writerspot
Lead editor Tracy Van Santana @tvansantana
Contributing editor Allen Blair @tinpoet
Founded by Ksenia Anske @kseniaanske
Current header by @aeforia.
Some of our favorite posts from new Ello members.

domain: artistic


text:
Portadown’s Adam Carroll who led Team Ireland to a historic victory in the A1GP series in 2009 has been confirmed to perform at Bavaria City Racing Dublin. The F1 extravaganza will provide five hours of free entertainment to members of the public in Dublin’s city centre on Sunday 3rd June.
Carroll is one of Ireland’s hottest motorsport talents having excelled in A1GP, GP2, AutoGP and the Indycar series with Andretti Autosport. Destined for a seat in an F1 car, Carroll has previously test driven for F1 teams.
Also confirmed to perform at the event is the Dutch Spyker Squadron team who have competed in the Le Mans 24 hrs and the Le Mans series since 2002. In 2009 a Spyker C8 Laviolette GTR2 finished fifth in the 24hrs of Le Mans Spyker Squadron is the race division of Spykercars, the Dutch luxury sports car range.
Spyker CEO Victor Muller, commented, “Spyker is very proud to be part of the first ever Bavaria City Racing Dublin event. I hope that the Irish people will enjoy seeing a Spyker C8 LavioletteGTR2 plus the brand new Spyker C8 Aileron super car on there beautiful city race track.”
Gavin Collins, Content Director of Bavaria City Racing Dublin, commented “Adam Carroll is one of Ireland’s most exciting emerging talents and it is only a matter of time before he is competing in the FIA F1 Championship. We are also delighted to welcome the Spyker Squadron who compete in the 24hr Le Mans race. These latest additions will bring added excitement to the F1 teams on show on the day.”
Bavaria City Racing Dublin will provide five hours of non-stop F1 and motorsport action for everyone to enjoy in the heart of Dublin city centre. Carroll and the Spyker Team will line up alongside an ever growing list of international and domestic motorsport talent that includes the Vodafone McLaren F1 team, Caterham F1 Team, the Aprilia Superbike team, the Motorbase British Touring Car team and the Mini Cooper WRC team.
The Bavaria City Racing Dublin F1 city track starts at the Convention Centre Dublin, continues along Customs House Quay before crossing Butt Bridge, chicanes at D’Olier Street, zips past College Green and the Central Bank on Dame Street before reaching the chequered flag on O’Connell Bridge.
Bavaria City Racing Dublin will take place on Sunday 3rd June and is a free public event and over 100,000 people are expected to line the streets of Dublin to enjoy the best of F1 and world motorsport.
For those who want to get closer to the action there are three ticketed premium performance zones on the track at Customs House Quay, O’Connell Bridge and at the Main Paddock on North Wall Quay. The O’Connell Bridge Performance Zone is sold out but spaces are still available at Customs House Quay and in the Main Paddock. Tickets for these areas are priced from €75.90 and are available from Ticketmaster.


text:
Heparanase is an endo-beta-glucuronidase that is capable of degrading heparan sulfate chains of proteoglycans, generating a variety of bioactive molecules such as growth factors and chemotactic and angiogenic agents. The expression of heparanase was investigated in the peripheral blood mononuclear cell fraction (PBMC) of 30 patients with breast cancer and 20 healthy control women by reverse transcription-polymerase chain reaction (RT-PCR) and immunocytochemistry. PBMC samples from all breast cancer patients at study entry showed the expression of heparanase, whereas no expression was observed for healthy women. Immunocytochemistry analysis demonstrated that heparanase was expressed in lymphocytes of breast cancer PBMC. Throughout follow-up, heparanase expression by RTPCR decreased significantly after surgery in patients treated with neoadjuvant chemotherapy (P = .002) and after tamoxifen treatment (P = .040), whereas it increased significantly with the advent of systemic metastasis (P = .027). In vitro, either serum from breast cancer patients or a medium originated from coculture experiments of MCF-7 cells and lymphocytes from healthy women stimulated heparanase expression in normal lymphocytes. The results suggest that there is a tumor-inducing effect on heparanase expression by lymphocytes present in the PBMCs of breast cancer patients, which depends, in turn, on the interaction between a tumor and normal lymphocytes.
MB-PDT is a cheap and efficient method of decreasing MM volume and thus disease progression. This reduction is mediated by downregulation of PCNA and heparanases.
OBJECTIVE:To determine the molecules involved in extracellular matrix remodeling and to identify and quantify heparanase isoforms present in herniated and degenerative discs.INTRODUCTION:Heparanase is an endo-beta-glucuronidase that specifically acts upon the heparan sulfate chains of proteoglycans. However, heparanase expression in degenerative intervertebral discs has not yet been evaluated. Notably, previous studies demonstrated a correlation between changes in the heparan sulfate proteoglycan pattern and the degenerative process associated with intervertebral discs.METHODS:Twenty-nine samples of intervertebral degenerative discs, 23 samples of herniated discs and 12 samples of non-degenerative discs were analyzed. The expression of both heparanase isoforms (heparanase-1 and heparanase-2) was evaluated using immunohistochemistry and real-time RT-PCR analysis.RESULTS:Heparanase-1 and heparanase-2 expression levels were significantly higher in the herniated and degenerative discs in comparison to the control tissues, suggesting a possible role of these proteins in the intervertebral degenerative process.CONCLUSION:The overexpression of heparanase isoforms in the degenerative intervertebral discs and the herniated discs suggests a potential role of both proteins in the mediation of inflammatory processes and in extracellular matrix remodeling. The heparanase-2 isoform may be involved in normal metabolic processes, as evidenced by its higher expression in the control intervertebral discs relative to the expression of heparanase-1.
IntroductionThe search for a specific marker that could help to distinguish between differentiated thyroid carcinoma and benign lesions remains elusive in clinical practice. Heparanase (HPSE) is an endo-beta-glucoronidase implicated in the process of tumor invasion, and the heparanase-2 (HPSE2) modulates HPSE activity. The aim of this study was to evaluate the role of heparanases in the development and differential diagnosis of follicular pattern thyroid lesions.MethodsHPSE and HPSE2 expression by qRT-PCR, immunohistochemistry evaluation, western blot analysis and HPSE enzymatic activity were evaluated.ResultsThe expression of heparanases by qRT-PCR showed an increase of HPSE2 in thyroid carcinoma (P = 0.001). HPSE activity was found to be higher in the malignant neoplasms than in the benign tumors (P<0.0001). On Western blot analysis, HPSE2 isoforms were detected only in malignant tumors. The immunohistochemical assay allowed us to establish a distinct pattern for malignant and benign tumors. Carcinomas showed a typical combination of positive labeling for neoplastic cells and negative immunostaining in colloid, when compared to benign tumors (P<0.0001). The proposed diagnostic test presents sensitivity and negative predictive value of around 100%, showing itself to be an accurate test for distinguishing between malignant and benign lesions.ConclusionsThis study shows, for the first time, a distinct profile of HPSE expression in thyroid carcinoma suggesting its role in carcinogenesis.
Abbreviations & Acronyms CS = chondroitin sulfate DS = dermatan sulfate ECM = extracellular matrix GAG = glycosaminoglycan GAPDH = glyceraldehydes-3-phosphate dehydrogenase HA = hyaluronic acid HS = heparan sulfate mRNA = messenger ribonucleic acid RCC = renal cell carcinoma RNA = ribonucleic acid Abstract: A better understanding of the molecular mechanisms of renal cell carcinogenesis could contribute to a decrease in the mortality rate of this disease. The aim of this study was to evaluate the glycosaminoglycans profile and heparanase expression in renal cell carcinoma. The study included 24 patients submitted to nephrectomy with confirmed pathological diagnosis of renal cell carcinoma. The majority of the samples (87.5%) were classified in the initial stage of renal cell carcinoma (clinical stages I and II). Heparanase messenger ribonucleic acid expression was evaluated by quantitative realtime reverse transcription polymerase chain reaction, and sulfated glycosaminoglycans were identified and quantified by agarose gel electrophoresis of renal cell carcinoma samples or non-neoplastic tissues obtained from the same patients (control group). The sulfated glycosaminoglycans and hyaluronic acid were analyzed in urine samples of the patients before and after surgery. The data showed a significant statistical increase in chondroitin sulfate, and a decrease in heparan sulfate and dermatan sulfate present in neoplastic tissues compared with non-neoplastic tissues. Higher heparanase messenger ribonucleic acid expression in the neoplastic tissues was also shown, compared with the non-neoplastic tissues. The urine glycosaminoglycans profile showed no significant difference between renal cell carcinoma and control samples. Extracellular matrix changes observed in the present study clarify that heparanase is possibly involved with heparan sulfate turnover, and that heparanase and the glycosaminoglycans can modulate initial events of renal cell carcinoma development.
The proteoglycan syndecan-1 and the endoglucuronidases heparanase-1 and heparanase-2 are involved in molecular pathways that deregulate cell adhesion during carcinogenesis. Few studies have examined the expression of syndecan-1, heparanase-1 and mainly heparanase-2 proteins in non-neoplastic and neoplastic human colorectal adenoma tissues. The aim of this study was to analyze the correlation among the heparanase isoforms and the syndecan-1 proteins through immunohistochemical expression in the tissue of colorectal adenomas. Primary antihuman polyclonal anti-HPSE and anti-HPSE2 antibodies and primary anti-human monoclonal anti-SDC1 antibody were used in the immunohistochemical study. The expressions of heparanase-1 and heparanase-2 proteins were determined in tissue samples from 65 colorectal adenomas; the expression of syndecan-1 protein was obtained from 39 (60%) patients. The histological type of adenoma was tubular in 44 (67.7%) patients and tubular-villous in 21 (32.3%); there were no villous adenomas. The polyps were <1.0 cm in size in 54 (83.1%) patients and ≥1.0 cm in 11 (16.9%). The images were quantified by digital counter with a computer program for this purpose. The expression index represented the relationship between the intensity expression and the percentage of positively stained cells. The results showed that the average of heparanase-1, heparanase-2 and syndecan-1 expression index was 73.29 o.u./µm², 93.34 o.u./µm², and 55.29 o.u./µm², respectively. The correlation between the heparanase-1 and syndecan-1 expression index was positive (R=0.034) and significant (P=0.035). There was a negative (R= -0.384) and significant (P=0.016) correlation between the expression index of heparanase-1 and heparanase-2. A negative (R= -0.421) and significant (P=0.008) correlation between the expression index of heparanase-2 and syndecan-1 was found. We concluded that in colorectal adenomas, the heparanase-1 does not participate in syndecan-1 degradation; the heparanase-2 does not stimulate syndecan-1 degradation by the action of heparanase-1, and the heparanase-2 may be involved in the modulation of the heparanase-1 activity.
The SQ method produced a greater sensitivity and specificity than did the index of expression method. There was a progressive increase in the mean HPSE2 immunoexpression according to the severity of the cervical lesion from the low-grade squamous intraepithelial lesion group to the invasive neoplasm group, whereas the normal group displayed the lowest level of expression. This is a novel study concerning HPSE2 in the cervix and cervical cancer carcinogenesis.
Objective Evaluate the effects of VEGF165 gene transfer in the process of remodeling of the extracellular matrix after an acute myocardial infarct.Methods Wistar rats were submitted to myocardial infarction, after the ligation of the left descending artery, and the left ventricle ejection fraction was used to classify the infarcts into large and small. The animals were divided into groups of ten, according to the size of infarcted area (large or small), and received or not VEGF165 treatment. Evaluation of different markers was performed using immunohistochemistry and digital quantification. The primary antibodies used in the analysis were anti-fibronectin, anti-vimentin, anti-CD44, anti-E-cadherin, anti-CD24, anti-alpha-1-actin, and anti-PCNA. The results were expressed as mean and standard error, and analyzed by ANOVA, considering statistically significant if p≤0.05.Results There was a significant increase in the expression of undifferentiated cell markers, such as fibronectin (protein present in the extracellular matrix) and CD44 (glycoprotein present in the endothelial cells). However, there was decreased expression of vimentin and PCNA, indicating a possible decrease in the process of cell proliferation after treatment with VEGF165. Markers of differentiated cells, E-cadherin (adhesion protein between myocardial cells), CD24 (protein present in the blood vessels), and alpha-1-actin (specific myocyte marker), showed higher expression in the groups submitted to gene therapy, compared to non-treated group. The value obtained by the relation between alpha-1-actin and vimentin was approximately three times higher in the groups treated with VEGF165, suggesting greater tissue differentiation.Conclusion The results demonstrated the important role of myocytes in the process of tissue remodeling, confirming that VEGF165 seems to provide a protective effect in the treatment of acute myocardial infarct.
scite is a Brooklyn-based startup that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
334 Leonard St
Brooklyn, NY 11211
Copyright © 2023 scite Inc. All rights reserved.
Made with 💙 for researchers

domain: medical


text: For all you pro swimmers out there: I am really trying to focus on swimming right now, working hard on my form since I have none. Got the endurance part down though. I am wondering if, while wearing a pull bouy (all I can do right now cause of stress fracture) I should feel myself rocking. I am trying to turn side to side with each stroke. I really concentrated on this today and could totally feel my body rocking slowly back and forth with each stroke. Is this a good thing??

domain: health


text:
Commodities markets have been quite agitated in May. The tremors felt on May 5 have not dissipated and recent data on the US economy, the risks of inflation in China’s and the protracted debt crisis in the EU left many traders wary. Prices of precious metals, industrial metals and oil have all dropped. So far, grains, led by corn, have held their value pretty well.
Corn is now being planted to be harvested in August. Weather is the main factor affecting the progress of planting and yields (#bushels per acre), and consequently a key driver of prices for new corn. Estimates indicate that the planting season is behind schedule, and that flooding of the Mississippi has destroyed some fields. Lower expected yields and acreage put further strains on an already historically tight ratio of stocks-to-usage – a measure of supply and demand.
Presumably these facts should have a greater impact on the incoming crop season (new corn). Yet, the recent sharp rally in corn prices occurred in nearby contracts (July futures) rather than in December futures contracts. Why is old corn more bullish than new corn?
One hypothesis is that momentum traders jumped back into corn with an emphasis on the most liquid contract, the nearest to maturity one. This is by no means clear after looking at the open interest and the CFTC data on the Commitment of Traders, which indicates a decline both in short and long positions by speculators.
The lower forecasted yields for new corn might suggest to some that a larger fraction of old corn should be stockpiled for delivery later in the year. But the term structure of futures prices is saying the opposite. Futures prices have become more sharply backwardated, with prices for July delivery rising faster than prices for December delivery. That is a signal that the value of prompt delivery has grown more than the value of storage for future delivery.
The lower forecasted yields do suggest that many farmers need to adjust their hedge positions. Many farmers are now over-hedged, having taken positions based on the earlier yield forecast. Quantity risk complicates the simple textbook model of hedging, requiring both a smaller hedge ratio, but also the dynamic adjustment of the hedge ratio as new information arrives. A farmer who fails to trim the hedge is exposed to more risk than a farmer who makes the needed adjustment. Of course, in this case, over-hedged farmers will find it expensive to liquidate a portion of their hedge since the price has risen and they must repurchase the position at a loss. But it is better to recognize that loss now and be properly repositioned going forward.


Posted Monday, April 5, 2004 7:56 AM | Contributed by supermandl
Crews at the Rockin' Raceway in Pigeon Forge Thursday removed the ride called the Hawk from the property following a fatal accident where a woman fell from the ride last month.
Read more from WATE/Knoxville.
Monday, April 5, 2004 9:30 AM
"But authorities have said the ride was in motion when the safety strap came undone."
Well, at least it would appear then, that the ride-op is cleared, now the question is why/how the restraint opened...
Monday, April 5, 2004 10:13 AM
I have heard some things, chatter to other parks that have Hawk's. The going theory is that the seat in question had some kind of broken part. In order to run the ride anyway, the sensor that checks the seat was bypassed, so the interlock that keeps the ride from running with a restraint failure wasn't doing its job. Parks run rides like this all of the time... but they block off that seat as well. It sounds as if the bypass was done without blocking the seat.
That's partly speculation, based on what some mechanic types have told me.
BATWING FAN SFA
Monday, April 5, 2004 11:20 AM
Well then it sounds to me like this doesn't fully clear the ops or management of any wrong doing.
If there was a broken part making that particular seat on the ride unsafe to occupy then they should've had it blocked off to begin with & the victim in this case should've been assigned to a different seat...or told to wait until the next ride cycle was loading to be re-assigned to said seat.
Monday, April 5, 2004 6:25 PM
So that explains why I didn't see it on my way to Dollywood Saturday.


text:
Vitacost Certified Organic Pure Matcha Green Tea Powder - Non-GMO Description
Premium, powdered green tea from non-GMO, certified organic Camellia senensis leaves.
Non-GMO, certified organic matcha green tea
Contains componds known as catechins
Ultra-fine, quick-dissolving powder
Mixes easily into hot water
What is matcha green tea?
Matcha is a type of green tea that’s popular in Japan. A fine, bright green powder, it’s ground from the highest-quality Camellia sinensis (green tea) plants, typically shade grown and harvested when leaves are young and brimming with phytonutrients. Matcha contains compounds known as catechins, which are the most important antioxidant flavonoids found in green tea.*
Vitacost Whole Foods Supplements
A natural, conscious approach to nutrition, from the inside out
Natural, non-GMO & certified organic
Free of artificial colors, flavors and preservatives
No chemical fillers, binders or stearates
Suitable for vegetarians or vegans
Labels printed on recycled paper with water-based ink
Vitacost nutritional products are manufactured to high standards of quality, efficacy and safety. Each Vitacost product meets or exceeds the standards and requirements set forth in the FDA’s Code of Federal Regulation (21 CFR, 111) Current Good Manufacturing Practices (cGMP).
Stir 1 scoop (approx 2 g) into 8 fl oz hot water. Adjust liquid to desired taste.
Keep dry and at room temperature (59°-86°F [15°-30°C]).
Milk, eggs, peanuts, tree nuts, crustacean shellfish, fish, soy, gluten, titanium dioxide.
These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.


Nissan Maxima Service and Repair Manual: Basic inspection
- Diagnosis and repair workflow
- Inspection and adjustment
Work Flow OVERALL SEQUENCE DETAILED FLOW 1.CHECK SYMPTOM Check the malfunction symptoms by performing the following items. Interview the customer to obtain the malfunction information (conditions and environment when the malfunction occurred). Check the symptom. 2.SELF-DIAGNOSIS (CONSULT) Connect CONSULT and perform "SELF-DIAGNOSIS" for "MULTI AV". NOTE: Skip to step 4 of the diagnosis procedure if "MULTI AV" is not displayed. Check if any DTC No. is displayed in the self-diagnosis results. 3.CHECK SELF-DIAGNOSIS RESULTS (CONSULT) Check the DTC No. indicated in the self-diagnosis results. Perform the relevant diagnosis referring to the DTC No. list. Refer to AV-607, "DTC Index".
ADDITIONAL SERVICE WHEN REPLACING CONTROL UNIT ADDITIONAL SERVICE WHEN REPLACING CONTROL UNIT : Description BEFORE REPLACEMENT When replacing AV control unit, save current vehicle specification with CONSULT configuration before replacement. AFTER REPLACEMENT CAUTION: When replacing AV control unit, you must perform "WRITE CONFIGURATION" with CONSULT. Complete the procedure of "WRITE CONFIGURATION" in order. If you set incorrect "WRITE CONFIGURATION", incidents might occur. Configuration is different for each vehicle model. Confirm configuration of each vehicle model. ADDITIONAL SERVICE WHEN REPLACING CONTROL UNIT : Special Repair Requirement 1.


text:
Click for larger image
On June 13, 2009, SLIPKNOT headlined the annual Download Festival in the UK, performing in front of 80,000 of their rabid fans. The performance was absolutely electric, in typical SLIPKNOT fashion. All SLIPKNOT shows are memorable, but this one is particularly memorable, as the band blasted through hits from all of their Platinum albums. On stage is SLIPKNOT in its most natural state and (sic)nesses will put you in the front row.
Perhaps most importantly, (sic)nesses is one of the final major performances for founding member Paul Gray, who tragically passed away in May 2010. While initially unintended, the concert is a testament to the legacy of Gray, where fans can enjoy a lasting glimpse of the bassist doing what he loved most.
Additionally, the DVD also includes a 45-minute behind the scenes documentary created by band percussionist Clown, as well as all four music videos from the All Hope Is Gone cycle.

domain: entertainment


Universal support. For P8xxx and Txxxx web sensor. Easy mounting on rack 19. Nuts and washers included.
Air chamber for measuring compressed air up to 25 bar
Product features Air chamber for measuring compressed air up to 25 bar
These products can interest you
Transmitter version with male connector. Waterproof IP67. Lumberg RSFM 4 for easy connection / disconnection ...
Universal support. Easy mounting on a 19 rack. Nuts and washers included.
Female connector. For TxxxxL transmitters. Easy disconnection from the outlet. Easily connected cable.


text:
Kent Theiling Jr., grounds and landscape design manager for the Danforth Campus, will lead a spring arbor tour from 11 a.m.-noon Tuesday, April 5. Those interested should meet at the south entrance of the Danforth University Center.
The walking tour will help participants learn more about the different trees and plants on campus. RSVP to firstname.lastname@example.org.
In case of rain, the tour instead will take place at 11 a.m. Thursday, April 7.
Comments and respectful dialogue are encouraged, but content will be moderated. Please, no personal attacks, obscenity or profanity, selling of commercial products, or endorsements of political candidates or positions. We reserve the right to remove any inappropriate comments. We also cannot address individual medical concerns or provide medical advice in this forum.


text:
Elizabeth Hurley didn't forget Hugh Grant's 60th birthday— she was just waiting to post something special for him! As Entertainment Tonight shares, while Grant's special day was on Wednesday, Hurley took to social media on Friday to make her birthday tribute.
Hurley honours Grant's birthday with Love, Actually clip
Hurley shared a video of Grant's infamous dancing scene from the 2003 movie Love, Actually on Instagram! In the clip, Grant's character "The Prime Minister" can be seen letting loose and dancing all over the place, thinking that no one is watching him. The actress also included a heartfelt yet humorous birthday message for the ex.
"A belated (because it took me two days to work out how to screen record)," Hurley explained in the caption of her Instagram post. "Happy 60th Birthday to the glorious Hugh Grant - a magnificent addition to the human race- even though he looks like a monkey. ❤ you forever xxxx"
Hurley and Grant were in a relationship for years
Hurley and Grant may not be together now, but they dated for 13 years! As Entertainment Tonight mentions, the pair were in a relationship until May 2000, but have continued to be close in the years following their breakup. Grant is even the godfather of Hurley's 16-year-old son Damian!
Though Grant ended up marrying Anna Eberstein a couple years ago, Hurley couldn't be more thrilled for her former flame! "He seems very, very happy," she said to Harper's Bazaar of Grant during an interview in 2018. "He has three children with his wife, Anna, who is adorable, and he’s a very happy man."
Hurley is currently single, but said that she wants to fall "madly in love" with someone once the coronavirus pandemic is over. And while she had fun screen recording Grant's Love, Actually dance, the actor revealed in a BBC retrospective last year that he considered the scene "absolute hell" while filming the holiday rom-com! Thankfully he powered through with it, creating one of the most iconic moments in the movie and giving his ex a fun way to wish him happy birthday years later!


text:
Hometown: Green Cove Springs, Florida
Currently Resides: Gainesville, Florida
Birthdate: August 16, 1996
Social Media: Twitter: @caelebdressel; Instagram: @caelebdressel
Toyota Vehicle: Toyota GR Supra
Olympic History: 2016
- 2019 World Championships, gold (50m fly, 100m fly, 50m free, 100m free, 4x100m mixed free relay, 4x100m free relay), silver (4x100m mixed medley relay, 4x100m medley relay)
- 2018 Short Course World Championships, gold (100m free, 4x100m free relay, 4x100m medley relay, 4x50m free relay, 4x50m mixed free relay, 4x50m mixed medley relay), silver (50m free, 100m fly, 4x50m medley relay)
- 2018 Pan Pacific Championships, gold (100m fly, 4x100m medley relay), silver (50m free, 100m free), bronze (4x100m mixed medley relay)
- 2017 World Championships, gold (50m free, 100m free, 100m fly, 4x100m free relay, 4x100m mixed free relay, 4x100m medley relay, 4x100m mixed medley relay)
- Olympic Games Rio 2016, gold (4x100m frees, 4x100m medley)
- American record holder for the 50m free, 100m free, and 50m fly
- World record holder for the 100m fly, 4x100m mixed free relay, and 4x100m free relay
About Caeleb Dressel
Caeleb Dressel is the son of Michael and Christina Dressel and has three siblings, Tyler, Kaitlyn and Sherridon. Swimming runs in the family with not only Dressel swimming, but also his father and two sisters.
Dressel graduated from the University of Florida where he won nine NCAA championships races. In 2016, he was named NCAA Co-Swimmer of the Year and later won the 2017 FINA Male Swimmer of the Year and USA Swimming Athlete of the Year.
Not only is Dressel considered to have the best start “off the block” in history, but he also became the first swimmer to win eight medals at a single World Championships in 2019. Dressel led the Cali Condors to an International Swimming League championship in 2020 and will join for season 3 as the Condors attempt to become the first club in ISL history to repeat as champions.
Dressel carries a blue and black bandana for good luck to the blocks for every competition. The bandana was worn by a former teacher, Claire McCool, who passed away from cancer and who Dressel considered his life coach. In addition to the bandana, Dressel is recognized for his tattoos, including an American flag to represent his love for the United States of America.
When he’s not in the pool, Dressel enjoys boating, wake boarding and being outdoors. He also loves animals and has a black lab named Jane. Dressel married his longtime sweetheart, Meghan, in their home state of Florida in February 2021.
Email Sign Up
Enter your email address below to sign up for email alerts.
All materials on this site are for editorial use only. The use of these materials for advertising, marketing or any other commercial purpose is prohibited. They may be cropped but not otherwise modified. To download these materials, you must agree to abide by these terms.I agree to the terms

domain: sports


text:
A former Arbeiderpartiet (Labor) politician, who served on the city council in Oslo, and had been deputy to Parliament, has been charged with fraud to the tune of close to 400,000.
The former politician has been charged with providing incorrect information to Nav for two periods in 2013 and 2014, according to Aftenposten. This led to him being paid unemployment benefits totaling 390,456, according to the indictment.
The indictment describes this as a rough figure, and the amount is significantly higher than the average in such cases.
On the employment status form the defendant gave to Nav, he wrote an address in Norway, but in reality he lived abroad for two periods which totaled 15 months.
The penalty for gross fraud is six years in prison, but normally the penalties in such cases fall far below this.
The case is scheduled for Oslo District Court in February.
Source: NTB scanpix / Norway Today


text:
This simple soup with peas and mint is a must for the begging of spring. A usual, just a few ingredients, simple recipe and a delight!
I love peas! Strangely, until then I didn’t care much. I believe it was under the influence of my grandparents. They told me to eat only peas from their garden and only when it’s the season. Unfortunately, they are far too far away for me to appreciate their harvest. They also would rapped on the knuckles because it’s not the season at all. Actually, I was inspired by Saint Patrick for this peas and mint soup. The mix of peas and mint is a classic in England and Ireland. Besides, we want this pretty green color for this party.
I’ve really liked soups since the beginning of winter. I make one of them almost every dinner. It’s very simple, you make a large pot of soup with the vegetables you have in your fridge. Since I’m the only one who eats it at home, I put the leftovers in glass jars that I put in the fridge and eat over several days. I usually bring a small slice of bread with my soup, sometimes with some hummus. It’s my winning dinner combo. I’m one of those people who doesn’t like to eat too much at night or I don’t sleep very well.
I find that adding some peas to a soup brings a little sweet taste and creamy that I love. I also added some zucchini to the recipe to make it lighter and ricotta for consistency. You can also use sour cream if you prefer. The good thing about soups is that they can be processed to the sandstones of our cravings and especially of what we have available.
I hope you like this recipe. Do not hesitate to send me pictures of your realization by email or Instagram, it is always a pleasure for me to discover them. Don’t forget to subscribe to my newsletter.Print
Simple spring soup with just a few ingredients.
- 2 cups peas (I used frozen peas)
- 1 cup zucchini slices
- 1 chopped onion
- 2 tbsp ricotta cheese
- 1 small bunch fresh mint
- Salt and pepper
- Olive oil and mint to add on top
- Put the peas, zucchini pieces, onion and mint in a pot. Cover with water and bring it to boil. Then, cover and let it cook for 20 minutes.
- Salt and pepper, add the ricotta and blend with a hand blender or in a traditional blender.
- Serve in a bowl and drizzle on top some olive oil and add some mint leaves.
Keywords: Soup, mint, peas, ricotta


text:
This tutorial explains how to make 3D art with acrylic powder!
It will demonstrate how to make a three-dimensional flower in a peach-pink color.
This lesson shows how to make a simple yet high-impact 3D flower.
The instructor uses acrylic to make a delicate three-dimensional blossom.
A flower made in acrylic powder of the same shade as the nail's base color
is simple but stunning.
Though it looks simple, by mastering the steps to bring out the flower's three-dimensionality and delicacy,
you can make intricate-looking 3D art.
This tutorial thoroughly explains the tricks necessary to create dimensionality that is essential for 3D flower art.
The instructor explains the methods for: making the most of the acrylics to form dimensionality, how to keep the edges sharp for a beautiful flower shape,
and how to make the 3D flower with just enough bulk so it won't get in the way of daily tasks.
In addition, the lesson explains:
◆How to add jewel stones to the flower center and keep them from snagging
◆When to use thick and thin brushes for acrylics
◆The right amount of water to add to your acrylic mixture
◆That one extra step for making the acrylic mixture last
◆How to make a flower with balanced features
and many other tips
that can be applied to all kinds of 3D art.
In this video the instructor uses a sophisticated pink, but you can use any color you like.
He also explains methods of prepping the acrylic color powder, so you can learn this too.
Also, though the instructor finishes off his 3D flower with jewels in the center,
he also explains how to use more acrylic to complete the blossom instead.
Since 3D art using acrylic powder is applied directly onto the nail,
you can do it quickly at the salon.
It's sure to be invaluable for your salon work, so please master the art of 3D flowers!

domain: hobby


Southwire DESAW 58282440 Drywall Jab Saw
Our drywall jab saw is designed to cut drywall more efficiently. The sharp tip excels at plunge cutting, and its aggressive tooth design cuts fast.
- Sharp cross-ground teeth cut through drywall, wood or plastic
- Over-molded cushion handle for comfort and firm grip
- 7" blade with cross-grained teeth allows drywall to be cut in both directions
- Sharpened tip easily plunges through drywall


Targets urged to cut Heathrow stacking
Targets to eliminate excessive aircraft stacking - where planes queue up to land - must be set if a third runway is built at Heathrow, a report by MPs said today.
The Government should also look at limiting noise levels and aircraft numbers over beauty spots, the report from the House of Commons Transport Committee said.
MPs were also concerned that the extension of the European Aviation Safety Agency's remit could mean a lowering of safety standards.
Entitled the Use of Airspace, the report said some stacking was inevitable but that excessive stacking such as frequently occurred at Heathrow in west London had "negative environmental impacts".
The committee said: "A third runway at Heathrow, if built, offers a real opportunity to add resilience into the air traffic management system and to help reduce excessive stacking.
"If a third runway is built at Heathrow, the Government should create a framework for setting targets to eliminate excessive stacking around the airport."
The report said that the Department for Transport (DfT) and the Civil Aviation Authority (CAA) should "examine the case for adopting maximum limits on noise levels and numbers of aircraft permitted per hour over sensitive areas such as national parks and Areas of Outstanding Natural Beauty".
MPs also called on the DfT to issue up-to-date environmental guidance to the CAA before the end of the year, with the guidance representing current Government thinking on carbon dioxide and other emissions in relation to transport decision-making.
The report said: "The Government and CAA must work to ensure that environmental assessments for airspace-change proposals use reliable evidence-based criteria."
The committee also asked for six-monthly reports on the European Aviation Safety Agency whose remit is now set to include aerodrome safety, air navigation services and air traffic management.
MPs said they supported the principles of the single European sky initiative to create a more rational organisation of European airspace.
The report concluded there was "much to commend" in the current management of UK airspace and that the committee had been impressed by the "technical competence and professionalism" of the CAA and of air traffic control company Nats.
MPs rejected suggestions that responsibility for decision-making about airspace be placed in a different organisation than the CAA.
However, the committee said the CAA should review the techniques it used to design controlled airspace around airports and improve the way it communicated with stakeholders.
The CAA should also encourage a choice of options wherever airspace changes were proposed.
The committee's chairman Louise Ellman MP said: "If a third runway at Heathrow Airport is built, then the Government should set targets to cut stacking.
"Tranquillity is a key factor in sensitive areas such as national parks. Current guidance appears to allow unchecked increases in aviation activity over these areas. Without some level of constraint, the noise environment in these areas may degrade progressively as traffic increases. The DfT should fund exploratory research on how to set useful limits."
Ralph Smyth, senior transport campaigner at the Campaign to Protect Rural England, said: "With ever more people holidaying in England this summer, the proposal to limit flying over sensitive parts of our countryside such as Areas of Outstanding Natural Beauty have not come a moment too soon."
The Independent travel offers: Discover a world of inspiring destinations
- 1 Nigel Farage: Me vs Russell Brand on Question Time – he's got the chest hair but where are his ideas?
- 2 Harry Potter fans can apply to the Hogwarts-inspired College of Wizardry
- 3 Jessica Chambers: 19-year-old woman 'doused with lighter fluid and burned alive' in the US
- 4 Russell Brand calls Nigel Farage 'poundshop Enoch Powell' in BBC Question Time debate
- 5 Orange Wednesdays are no more
Disgruntled RBS worker writes hilarious open letter to Russell Brand after anti-capitalist publicity stunt leaves him hungry
Nigel Farage defends Kerry Smith 'ch***y' comment: 'If you are going for a Chinese, what do you say you’re going for?'
Nigel Farage's approval rating hits 'record low' as popularity suffers in wake of Ukip sex scandal
Rozanne Duncan: Ukip expels councillor for 'jaw-dropping' comments made in BBC TV interview
Sony hack: Angelina Jolie branded 'seriously out of her mind' in further embarrassing leaked email saga
Panic Saturday: 13 million Britons spend £1.2bn – while 13 million others across the country live in poverty unable to afford food
£240 - £275 per day: Investigo: Support the global business through in-depth a...
Negotiable: Ashdown Group: Data Manager - MySQL, Shell Scripts, Java, VB Scrip...
£27000 - £32000 per annum: Ashdown Group: Application Support Analyst - near S...
£23000 - £27000 per annum: Recruitment Genius: This successful group of compan...


text:
Sen. Mitt RomneyWillard (Mitt) Mitt RomneyBipartisan Senate group discusses changes to election law There is a bipartisan path forward on election and voter protections Momentum builds for new COVID-19 relief for businesses MORE is adding some pep — and a mustache — to the upper chamber, debuting a "Ted Lasso"-inspired costume for Halloween.
The Utah Republican posted an image of himself on Thursday dressed as the Apple TV show's earnest protagonist, complete with a Lasso-ism or two, and a little "Friday Night Lights":
If you believe in yourself, and have clear eyes and full hearts—you can’t lose. pic.twitter.com/CpkmFKo49i— Mitt Romney (@MittRomney) October 28, 2021
Sen. Kyrsten SinemaKyrsten SinemaPoll: 30 percent of Americans say they approve of the job Congress is doing Bipartisan Senate group discusses changes to election law Democrats ask for information on specialized Border Patrol teams MORE (D-Ariz.) played along with Romney's turn as Lasso — subbing in for Hannah Waddingham's character on the show, AFC Wimbledon owner Rebecca Welton.
Biscuits with the boss. pic.twitter.com/tKpiToDWE6— Mitt Romney (@MittRomney) October 28, 2021
ITK hears Romney is a fan of the Apple TV series, and he's previously put his own spin on coach Eric Taylor's famous catchphrase from "Friday Night Lights."
Clear Eyes, Full Hearts, America Can't Lose pic.twitter.com/O1xJ5071— Garrett Jackson (@dgjackson) October 23, 2012
Jason Sudeikis, who stars as Lasso, frequently portrayed Romney on "Saturday Night Live" during the then-GOP presidential nominee's 2012 White House bid.
It's not the first time that a member of the Romney clan has gotten in the Halloween spirit.
Back in 2019, the 74-year-old lawmaker's grandson, Thomas Romney, dressed as "Pierre Delecto." The fictional French figure was the name of Romney's online alter ego that he used for a Twitter account.
Updated at 12:12 p.m.


Moto G6 and G6 Play are coming to India soon enough, reveals company teaser. However, the exact launch date of the phones is yet to be confirmed by the company. Motorola had launched both the Moto G6 and G6 Play in Brazil last month, alongside Moto G6 Play. For now, there's no word if Motorola will bring the Plus variant to India or not. Most likely no. At least not right now. Moto G6 Play is a budget segment phone and comes with a toned down hardware setup when compared to the Moto G6, which is a mid-range device.
Apart from some design similarities here and there, both the Moto G6 and G6 Play vary in almost all aspects. In Brazil, the Moto G6 Play is available at a starting price of $199, which roughly translates to Rs 13,135. While, the Moto G6 price starts at $249, which when translated comes around Rs 16,435. The India prices of the phone are yet to be revealed, but we expect the Moto G6 to be priced around Rs 15,000, while the G6 Play may cost around 10,000. In Brazil, the Moto G6 was launched in four colours -- Deep Indigo, Black, Blush, and Silver, Moto G6 Play was made available in two colours -- Deep Indigo and Flash Gray. We are not sure if Motorola will bring all the colour variants of the phones to the Indian market as well.
The Moto G6, although may be slightly expensive than the Play model, comes with the same screen size, but different resolutions. While the Moto G6 comes with full-HD+ screen resolution, the Play model has an HD+ resolution. Both the G6 and G6 Play sport a 5.7-inch bezel-less display with an aspect ratio of 18:9.
#helloyou, gaming pros, techies, movie buffs, artists, photographers, explorers, fashionistas! Gear up for the #motog6 and #motog6play, designed with you in mind. Register now to be the first one to get all updates. https://t.co/7DwB9QAEkZ pic.twitter.com/n1RYPSy45QMotorola India (@motorolaindia) May 15, 2018
In comparison, the Moto G6 is a more powerful phone compared to the G6 Play. The Moto G6 Play is powered by a 1.4GHz quad-core Qualcomm Snapdragon 427 processor, while the Moto G6 is powered by a more powerful octa-core Qualcomm Snapdragon 450 processor clocked at 1.8GHz. The Moto G6 Play comes in two variants - 2GB RAM/16GB of internal storage and 3GB RAM/32GB storage. On the other hand, the Moto G6 comes with 3GB RAM/ 32GB storage and 4GB RAM/64GB of internal storage. We expect Motorola to launch both the models of the phone in India as well.
On the camera front, the Moto G6 comes with dual rear cameras, consisting of a 12-megapixel primary sensor and 5-megapixel secondary sensor. The Moto G6 Play, on the other hand, comes with a single rear camera which includes a 13-megapixel sensor with f/2.0 aperture. On the front, Moto G6 Play and Moto G6 come with an 8-megapixel selfie camera. Both the Motorola phones run on Android 8.0 Oreo software out-of-the-box. The Moto G6 is backed by a 3,000mAh, while the Moto G6 Play is more powerful and comes with a massive 4,000mAh battery. The Moto G6 comes with 15W TurboCharging support, while the Moto G6 Play comes with support for 10W fast charging.