Ever needed to click on the same place every minute? By installing an auto clicker, you put your fingers as well as the physical mouse to the much-needed rest, while the Auto Clicker does its task with absolute finesse. Total reviews in google play store 10747. They are pretty much good to go from the word start. Keyboard Shortcut to Start and Stop Automatic Clicking The Notification Icon of this Software displays the name of the Keyboard Shortcut assigned as displayed in the screenshot below. Scheduling Mouse Clicks on Desktop or on Webpages can be done in the above mentioned software. Whether you want to Click Cookies with this Clicker or you want to Fire Missiles or even Harvest a Farm, just make sure that you do understand what all features are available and how to use them in best possible way. Choice of right or left mouse click.
This method of launching the Macro Recorder will make sure that your Mouse and Keyboard Actions are recorded properly irrespective of the Game you are playing. Added a few minor options v1. Auto Click by Holding a Key Down This method of Automated Mouse Clicking in a Game send Mouse Clicks as long as you are holding a Keyboard Key down. Yes you can even save the Recorded Macro and then load it later for Playback. Location of Automated Mouse Clicking Location of Clicking : You can either choose to do Automated Mouse Clicking wherever your Mouse Cursor is present or you can specify a Fixed Screen Location. Description The Autosofted Mouse Clicker and Recorder is a simple to use yet powerful tool.
Note in the above screenshot, the time delay defines is for 0 Minutes, 0 Seconds and 0 Milli Seconds which effectively makes this Auto Clicker really the Fastest Mouse Clicker. This Software has a mode for Clicking in Games which allows you to automate mouse clicking in Desktop Game Clients and even in Games protected by Game Guard. You can use our Speed Auto-Clicker to eat very fast while you are fighting with your dino! How to Use Auto Clicker Simple and Easy to use Auto Clicker allows few configurable options. Note that you can also define Extra Random Time Delay so that the Automated Mouse Clicking sent to the Game is like a Human doing the Mouse Clicking. Download auto clicker free download. You only need to install antivirus software in your computer. This app is a good way to save yourself tons of effort when you are performing a repetitive task or, for example, when you are playing a game that only requires you to click.
Another best thing about this Auto Clicker is that it does not requires permission of your Computer Administrator to Install. Ich schicke dir dann eine Mail. Effectively, if you want a Fast Clicker, you must define low time delay values and if you want Slow Clicker, you must configure a large time delay value. Apart from the configurable option, Auto Clicker also shows the number of Mouse Clicks automated. Free Mouse Clicker is freeware and can be used by anyone.
The Auto Clicker Software Download is offered on a free to try basis. Auto clicker is simply a set of well-written programs or macros, which are widely used in the online games to automate a particular repetitive action without physically doing it. Added double clicking and triple clicking 3. Update 3-3-2017: The program can now also record right clicks! If there has Trojan horse virus, antivirus software will delete it instantly. All trademarks, registered trademarks, product names and company names or logos mentioned herein are the property of their respective owners.
Our highspeed Auto-Clicker works great on Clicker Heroes. Keyboard Shortcut Info on Notification Icon of Auto Clicker With this Powerful Mouse Clicking Tool, you do not need to worry about straining your fingers and you can simply let this Best do the Mouse Clicking for you. Fast Clicking, Clicking with Random Time Delay, Clicking at Random Location around Mouse Cursor, Game Clicker for Full Screen Game Clients, Fast Clicking at Fixed Screen Location or Current Mouse Cursor Position and much more together make this really the best for all Online and Desktop Games. In Cookie Clickers you click for cookies! Become the biggest cookies factory in the world! There are many kinds of games in the internet. All the Clickers mentioned above work on Windows 10, Windows 8.
Another unique feature is the click rate limitation. They can be automated to create an output, which was recorded earlier or created from the different current settings. Our mouse clicker is completely self-contained and can be used for any software or games. Best Auto Clicker The above Screenshot displays what all makes this Auto Clicker Best for Automated Mouse Clicking with Mouse. Once you have assigned a Keyboard Shortcut, you can Minimize the software or hide it to System Tray.
It can be used to finish a particular task in the game in the minimum timeline and move further to the next level. So, if your task consists of clicking on two different buttons in different points of the screen you have to insert two tasks: point one and point two. The Game Clicker offers far less control of Automated Clicking, however the Auto Clicker is much more sophisticated and offers super fine control of how you can send Mouse Clicks to Active Game or any other Application. WikiExt monitors and provides timely updates for its database in order to have up-to-date information and the latest programs for opening any file types at all times. In general apk file Auto Clicker has rating is 4. Now, every country has many game developers. Game auto clicker tools are available in large quantities.
There are no special instructions are required to accommodate these specialised programs. You can explore various features of the software from the right click menu and displayed in the screenshot below. If you are looking for more free alternatives, we recommend you to download or. Options to set mouse auto clicks for the left or right button. The last few years, many young personal developer joined game developing staff.


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Bon Iver shared another song from their upcoming third album 22, A Million early Monday. “33 “GOD”” is the third song the Justin Vernon-fronted project has released off their new collection, which follows 2011’s Bon Iver, Bon Iver.
“33 “GOD”” arrives after ”22 (OVER S∞∞N)” and “10 d E A T h b R E a s T ⚄ ⚄.” Bon Iver released studio versions of those songs earlier this month after debuting the album in full during a live performance at the Wisconsin’s Eaux Claires Music & Arts Festival. Vernon, along with Aaron Dessner of the National, founded the event in 2015.
Bon Iver have been dormant since 2011, but Vernon has not. In 2013, he released an album, Repave, with Volcano Choir and another album, Grownass Man, with the Shouting Matches. He also appeared on Kanye West’s album Yeezus that year; West recently called Vernon his “favorite living artist.” Earlier this year, Vernon guested on James Blake’s album The Colour In Anything. “He’s just got his mouth and gold just falls out,” Blake told EW.
22, A Million is out Sept. 30. Check out “33 “GOD”” below.

domain: entertainment


Michael Copeland MLA has hailed news that draft legislation for a Tenant Deposit Scheme in Northern Ireland will be brought before the Assembly before the summer recess as an example of Ulster Unionist delivery on the floor of the Assembly.
Michael, who brought a motion on the issue to the Assembly said:
Tenant deposits being withheld by landlords is something that has affected many people in Northern Ireland. The Ulster Unionist Party highlighted the gross unfairness of a situation which led to many facing deep financial implications when we emphasised the issue on the floor of the Assembly in January.
We called for a scheme which would see tenants deposits held by an independent third party and we are glad to see that this is expected to be what is proposed in the draft legislation. This will be very welcome news to anyone living in privately rented accommodation as it will safeguard their deposits from being withheld unfairly.
I look forward to seeing the draft legislation coming before the Assembly and I and my Party will be giving it the appropriate scrutiny to ensure that it will provide an effective solution to the current set up


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Written by Joe Lane
Published: September 9, 2004 at 8:13 PM
The great thing about Seuss Landing at Islands of Adventure? The detail. Those of us who grew up reading Dr. Seuss books are hit in the face by the nostalgia of it all, and yet, there are still things folks miss off the beaten path. Here's a short sample:
This sign is displayed right at the entrance of Seuss Landing from the Port of Entry. The inscription reads: "To Theodor Geisel 'Dr. Seuss' We Dedicate this Island to Dr. Seuss, May His Genius Forever Be On the Loose! And to Mrs. Geisel, Fondest Thanks Too, For Guiding Our Way Clear to Solla Sollew!"
"One day, making tracks In the prairie of Prax, Came a North-Going Zax And a South-Going Zax..." And here they stand, north and south, neither budging for the other. You can find them, along with a dozen other Seuss bonus items on the coastline of Seuss Landing. Many people take the main thoroughfare past The Cat In The Hat Ride, but a quick left before the Green Eggs And Ham stand will take you around to the far exit of the island and the entrance to The Lost Continent quicker than usual.
Well go ahead... think of 'em!
Well, by George, there IS a Zamp in the lamp! You can find this one near the front of the Mulberry Street Store. Inside...
... a Geeling on the celing. This is obviously a play off the Seuss book "Wocket In My Pocket".
It's the egg from "Horton and the Egg"--a unique photo op hidden behind the Cats, Hats and Things store. Get a shot of a friend one sitting on the lazy bird Maisie's egg--it not only makes for an amusing picture, but also has a hidden conotation that the sitter has some connection to an elephant. Seriously, folks, if you haven't read the story, you need to find a copy and read it. No words yet whether or not an elephant bird has been hatched (or any human birds, for that matter).
Even the no entry signs in Seuss Landing demonstrate the same propensity for rhyme and reason that any good Seuss book would. These are the things you wouldn't normally see unless you really took the time to look for them. That's why it's a part of what you've been missing!
Remember to keep on ridin'!
Walt Disney World

domain: library


Rick Ross’ Ankle Monitor Causes Alarm At White House
This past week Rick Ross was among several rappers to attend President Barack Obama’s meeting for his My Brother’s Keeper Initiative.
While at the meeting the MMG boss’ ankle monitor went off reportedly startling some in attendance.
According to TMZ, President Obama had just concluded speaking on his initiative that looks to keep Black males out of jail.
The monitor must be worn by Ricky Rozay in order to meet the terms of his release amidst alleged kidnapping and assault charges.
Ross was previous indicted on egregious offenses, including kidnapping, aggravated assault, aggravated battery, and possession of a firearm while committing a crime.
Just last month Ross scored a victory in court after a sexual assault lawsuit that was filed against them last year was dropped.
The original complaint was filed in September 2015 by a woman claiming to be drugged and raped by Rick Ross’ bodyguard, nicknamed “Black.”
The woman says “Black” spiked her champagne on a ride back to the W Hotel.
No word on how Ross will be helping with Obama’s initiative at the time of print.


text: Stories evermore introducing 10 top varieties stories to you. The children's can improve their reading skill and languages. An easy to read young children's storybook about embracing 10 best stories. The books help kids learn to read and make excellent bedtime stories! We have ten top great children's stories for you to share. Stories are told with interesting illustrations. This book is published by Poornna publications.


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International National politics
7 Oct 2013
If the United States Ratify the Comprehensive Indivisible Test Suspend Treaty? Nuclear weapons can be a touchy subject nowadays, especially with more and more countries around the world performing war or perhaps finding the ways of developing this sort of objects. Getting one of couple of countries with this electric power has induced a riff in the standard opinion of what to do when ever faced with Since the first elemental tests 66 years ago up until the very last American ones in 1992 there has always been controversy about testing and also possessing these people. Testing qualified prospects from creation to use and many people around the world have a problem accepting the truth that America, as a superpower if not the only one even now intact, features nuclear weapons even though we all haven't took part in in tests them for over 20 years.
The 2 sides with this argument comes with Ellen Tauscher who states that there is does not require further nuclear testing thus America should certainly vote all over again on the CTBT and choose to ratify it so that it can be passed down the road. Baker Early spring argues that you have reasons why the Senate did not wish to move this treaty in the first place and the ones reasons remain relevant today. Ellen Tauscher mentions that President Obama wanted to " reduce the part of nuclear weapons within our national reliability strategy and urge other folks to do similar. вЂќ Since President Obama came into presidency we have done quite a bit in order to move themselves further and further from addiction on our nuclear guns. We created the START contract, adopted the Nuclear Posture Review, and made a consensus at the 2010 Nuclear non-proliferation Treaty Assessment Conference. The way things appeared to be going it appears as if it can be true that the shift from any type of substance warfare is occurring in our lifetimes. Tauscher believes that in ratifying the CTBT it is going to allow us to further study nuclear weapons, she declares that having this " binding banвЂќ eludes the country about our...

domain: politics


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How To Calculate House Tax
It is vital that you keep away from renting a vehicle from the effectively recognized car rental brands such as Avis, Hertz and so on. These organizations charge substantially greater rates than other rental companies since they are so properly known in the business. You happen to be in fact a lot far better off by renting a car from a lesser recognized rental company because they are far more most likely to provide a reduced rate as well as be a lot more lenient when it comes to late drop offs.
A luxury auto broker could choose to function at a luxury auto dealership that's been about for quite some time, or click through the up coming web page they could choose to open up their own dealerships. Most luxury auto dealerships function closely with other dealers and private sellers, shipping firms that can import cars, banks and of course, their clientele. A luxury auto broker could work in an office or they may possibly travel between distinct cities to meet with their clientele.
And I did, but only for a extremely short yet ecstatically content 9 months. The advice I did not take is what led its departure. In the simplest terms and most handy definition, I could not afford it. I was a broke college kid driving a 15 year old luxury auto on a ramen noodle spending budget.
Check the insurance group rating of the precise model you have in mind before purchasing at Thatcham Research The larger the quantity, the bigger your premium is likely navigate to this site be. It really is also worth checking our Inexpensive Vehicle Insurance coverage guide to see what the probably price is.
In today's marketplace, buying utilized luxury automobiles is a smarter decision than ever before. Our wide selection of inventory and flexible lease options will help get you into the auto you need! Plus, we provide auto leasing plans with low month-to-month payments. Here's more info about Navigate To This Site have a look at our own web site. Take a appear at our current lease specials on the internet, and give us a get in touch with at 832-369-8318 to learn a lot more.
Why Edmunds Recommends the 2017 Audi A7: Take almost everything we said about the A6 above and apply it to the Audi A7. The two automobiles are fundamentally related, but for a greater price tag (normally about $10,000, comparably equipped), the A7 provides sleeker styling and a radically raked hatchback that affords a bit far more versatility. Rear seat headroom does suffer a bit relative to the A6, but slouching is rarely needed. Note that the A7 can be had only with the supercharged V6, though there are the larger-functionality S7 and RS 7 variants obtainable.
All payments are made by credit card by means of the telephone application service. You have to add your credit details very first, in order to be capable to use the application. Buy a car with an all-wheel drive. Except for sports automobiles, where a rear-wheel-drive is usually preferred, 4-wheel drives are worth significantly much more at resale time.
You want to get a classy car, but you do not want the hefty value tag that comes with it. Purchasing a employed luxury auto doesn't make it much less luxurious truly, it really is a wise move. Getting a employed auto will support you save funds while still giving you the flashy look.
When you buy a utilised car you'll be given a bunch of documents, so check you have got the proper ones prior to paying up. A basic PPI is typically $one hundred-200, and the cost is the buyer's responsibility. If the mechanic finds recommendations that should be taken care of, then you'd decide to either drop your price or repair the things to make the sale.
Bonus Tip: When you are comparing various cars, never neglect to compare insurance coverage fees as effectively. Perform with an independent insurance coverage agent who can support you save with no losing on coverage. At times companies design and style cars specially for the silver screen and here are the ten best film notion cars ever, as voted for by you.
Luxury, by its extremely nature, is utterly unnecessary, but that is not to say it really is without its makes use of. Visit many dealerships ahead of negotiating a price tag. Check out the dealerships that gave you the best on-line quotes for your luxury vehicle and inspect the auto your self. Make it clear to the dealer that you are visiting several dealerships to find the very best deal, and walk away soon after inspecting the auto completely.
This is another 1 that several folks don't take into account, as when the majority of us envision buying a vehicle we picture walking on to the car lot. Nonetheless, on-line vehicle shopping is rapidly becoming a new and properly-loved trend. Not only is it frequently a lot more practical but also you are in a position to comparison shop from the comfort of your personal property so that you know you're acquiring the very best cost on your luxury vehicle.
Technologies such as cylinder deactivation, exactly where the engine shuts off some of its cylinders under low power demands, can squeeze out slightly better mileage in highway driving. An increasingly widespread function is engine shutoff when the vehicle is stopped, such as at a visitors light. The engine will shut off, rather than idle, to save fuel. It will restart as quickly as the driver lifts off the brake pedal.

domain: finance


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Re: crosswind affects drop
I'll admit up front that I've only skimmed the posts to this thread so I'll apologize if I'm repeating anyone...
There is a vertical component of deflection for spin stabilized projectiles in a crosswind, even a pure crosswind. The deflection is as described above (from 10 O'clock to 4 O'clock). The angle of the slant is proportional to the stability factor of the bullet; the stronger the stability of the bullet, the steeper the slant.
A gyroscopic stability factor of 1.5 (low) will result in about 16 to 17 degrees of 'slant', which corresponds to about .3 MOA of elevation per 1.0 MOA of windage.*
A gyroscopic stability factor of 3.0 (high) will result in about 23 to 24 degrees of 'slant', which corresponds to about .4 MOA of elevation per 1.0 MOA of windage.
The vertical deflection results from a process known as 'aerodynamic jump', which an aerodynamic/gyroscopic 'thing' the bullet does as it aligns it's axis (weathervanes) in a crosswind.
All of the above is the book answer.
One of my favorite quotes is: "In theory there's not difference between theory and practice, but in practice there is".
The book answer can be observed in the real world, and I've seen clear evidence of it myself when shooting 20 shot matches at 1000 yards in different wind conditions. In fact, yesterday I shot in the Palma Individual match at Camp Perry. I had 4 to 5 MOA left windage on at 800 yards and my elevation zero was 3/4 MOA higher than my 'no wind' elevation. At 900 I used 9 to 11 MOA left and my elevation was about 1.25 MOA higher. At 1000 I ran 10 to 11 MOA of wind and my elevation was about 1.5 MOA greater. I'm shooting 185 BT's from a 1:13" twist which results in a pretty low stability factor, so I have a pretty shallow deflection angle. Also the wind was 7-8 O-clock which biased my elevation up some...
There are other real world effects that can act to mask or distort the magnitude of the slant. For example, if there's a component of head or tail wind, that can affect the vertical impact slightly. Also if your sights don't track perfectly horizontal you may unknowingly induce a vertical adjustment to your aim when you add lots of windage. Probably the biggest one is if the terrain that you're shooting over is hilly or rolling; there may actually be vertical wind currents that simply deflect the bullet up or down.
In summary, aerodynamic jump is real, and it does cause a 'slanted' deflection. However, it may not appear the same to everyone in every condition because of other variables involved that are of equal or greater influence.
* Ref: Rifle Accuracy Facts, Harold Vaughn

domain: hobby


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Wendy Tandy can give you a good idea of just how crazy rich Asian weddings are. Tandy is the man behind Kartoe – the world’s leading designer in luxury invitations, event invitations, gala invitations, brand identity, website design and fine stationery.
Having been in the business since 2009, Tandy’s handwork – pun often intended since he draws and designs invitation cards – is instrumental in making the biggest day of any couple’s life a reality.
Beyond wedding, he was commissioned here for Shanghai Film Festival, working on the exclusive set of invitations for the festivals A-list attendees.
Watch the video to see how the 4-layer lasercut papers come together to make a spectacular invitation for Shanghai International Film Festival. Fun fact: the design was not printed or foiled in gold, but it is made of 4 layers of lasercut black and gold papers layered on top of each other. . #kartoe #geometric #thebund #shanghai #fashionweek #filmfestival #graphicdesign #luxuryinvitations #invitationcards
He cites one of his Indonesian clients who was the first ever to use the entire Florence Duomo – one of Italy’s landmark – as their wedding venue. They leveraged on the luxury and featured the entire duomo designs extensively on their cards.
“Guests were treated to a tour to (the Salvatore) Ferragamo workshop and everyone got a free bag from Ferragamo, personalised with their names. A glasshouse was built solely for the after-party and it was taken down the next day.
“Another client from Hong Kong actually flew (British band) Coldplay’s lead vocalist Chris Martin in to sing for their wedding which was held in France,” Tandy shares.
Some of the star-studded couples that Tandy had designed wedding invitations for, and other accompaniment which sometimes include itineraries to destination weddings, were Berjaya heiress Chryseis Tan and Faliq Nasimuddin of the Naza Group fame, financier Justin Chai’s marriage to YTL’s Niche Retailing executive director, Yeoh Pei Nee and Ekovest’s Lim Chen Thai’s wedding to his wife Jeannie.
Congrats to Justin & Nee for your recent wedding! Presenting the look at their invitation design that features custom wedding logo, watercolor painting of @themajestichotelkl and hand-drawn florals, printed on cotton paper and gold-flaked paper. . The couple has been recently featured on @prestigemalaysia Aug 2018 Edition. . Wedding Planner: @peakxperience . #kartoe #handpainted #watercolor #pinkleather #themajestichotelkl #justmarriednee
Tandy says clients are getting increasingly appreciative towards the work and artistry that designing invitations require. He adds that the work demands for unconventional designs that are “more than just prints and papers.”
[Swipe for more] One of our most intricate pieces to date! A christmas greeting card for an esteemed international florist, the card itself is made of 20 layers of individually laser-cut paper that stacks up to form a complete design, the design was inspired by Quran and Morrocan Mosque architecture. The english title on the cover was hand-calligraphed by @connie.rie pairing it with our hand-illustrated intricate pattern. . Calligraphy: @connie.rie Photography: @mr_hendra . #kartoe #luxurystationery #christmascard #greetingcard #morroco #mosque #lasercut #foilstamp #couture
However, Tandy notes, clients are more daring and bold, very experimental and are open to possibilities.
“I believe many people have finally started to accept the fact that invitation card is one of the important aspects in the wedding, no longer a piece of paper that you throw away after receiving it.
“Clients have put more attention into designing the invites because good invitation cards build up the anticipation among guests. Since the demands are there, more designers have put more thoughts into their artworks too, so every designer in the world has to bump up their designs skills to be unique.
“This drives the industry into a much more interesting scene. Everyone is trying to create their own trends. Watercolours on invites were very rare in the past, now it seems like everybody is doing it and has to do it,” Tandy shares with Signature Weddings.
Clearly, the follow up question would be related to how expensive can invitation cards get.
“The sky is the limit; so is the pricing, as long as they are willing to spend on it,” Tandy notes frankly.
Divulging details, Kartoe’s most expensive card was priced about SGD200 per set. This accounts for the card, envelope and any other accompaniment.
Tandy says there are many factors that go into determining the price of a card – the materials, printing techniques, size and card layout. The quantity of cards to be produced and if manual labour is required into its assembly is also factored in.
“Some of our cards are painted individually by hands, some are hand-woven individually and so these are some of the factors that need to be accounted for,” Tandy says, adding that he cannot pick a memorable wedding to date.
“All of the weddings I have done so far are memorable on their own. It is very hard to pick one. There’s always a surprise in every wedding I do.
“Sometimes you meet a client (and) you do not even know who they are until they reveal their personal details and (then) you get wowed,” Tandy shares, matter-of-factly.
Seeing that his skill is a niche in the wedding industry, the proud Medanese who is based in Singapore, says the greatest challenge lies in being able to develop new ideas and designs that are unique from each other. This is even harder since his clients are within the same social circle.
“Everyone knows each other so it is an opportunity for them to outdo each other and be unique,” he adds. However, the silver lining Tandy takes away is that this presents an opportunity and a good challenge for him and his team of three designers.
Need to refresh your memory on a crazy rich Asian wedding? Here is one of Malaysia’s most extravagant weddings yet this year: #chrysfaliqeverafter: Iconic wedding of the year.

domain: design


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Topic: Slam in the Star Bar
Well worth checking tonight as there's no special guest in the Main Room.
The guys were at the forefront of the first Progressive House era back in the early ninties, recording early prog classics such as Positive Education and championing labels such as Limbo and of course there own imprint Soma.
They've been at the forefront of the dance scene ever since, although their sound could now be described as Tech-House and Techno.
Anyone gonna join me at some point?

domain: artistic


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Earlier today, an announcement regarding the future of THE IDOLM@STER MILLION LIVE! (Greemas) was posted in game. To prepare for the end of service of the game in the near future, the game will stop updating and start disabling features from December 2017 onwards.
The final event for Greemas titled Thank You! Million Live Final Party! will be held on the middle of November until the end of the month.
A finale campaign titled TH@NK YOU FOREVER!! will be held from 31 October 2017, and details will be announced in game then.
List of services ending:
- Platinum paid gasha will end at 1 December 2017 at 9:59 JST.
- Sales for shop event sets will end at 30 November 2017 at 23:59 JST.
- Comeback Mail Campaign will end at 30 November 2017 at 23:59 JST.
- Invitation campaign will end at 1 December 2017 at 9:59 JST.
- President Missions will end at 1 December 2017 at 9:59 JST.
List of updates that will stop:
- Audio Room won’t be renewed after 30 November 2017 at 23:59 JST.
- Dengeki Mao Comic previews won’t be renewed after 30 November 2017 at 23:59
- Birthday Celebration Messages will end after Sayoko’s birthday on 29 December 2017.
- The last batch of character voices will be added at the middle of November 2017
List of changes:
- Live Battle Theater Kuji will be changed from HR points to Star Medals.
- The rewards for jobs will be changed to Million Jewels.
- Login Bonuses will be changed to give out 300 Million Jewels + 30 Fan Letters + 30 Fan Presents from 31 October onwards.
Thank you Million Live, may you continue your shine in Theater Days.


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Medicine Unboxed 2011
Medicine and Values
Parabola Arts Centre, Cheltenham UK
Tickets for Medicine Unboxed 2011 are available direct from Parabola Arts Centre's online booking page.
09.20 – 09.30 Introduction and chair
09.30 – 10.00 Facts and values in medicine
10.00 – 11.00 Patients, medicine and values
Ray Tallis, Havi Carel & Tom Isaacs
11.00 – 11.25 Coffee
11.25 – 11.50 An epidemic of loneliness
11.50 – 13.15 The window of literature
John Carey, Jo Shapcott, Michael Arditti & Paul Bailey
13.15 – 14.00 Lunch
14.00 – 14.50 Ethics and Law: a debate
Sheila McLean & Richard Huxtable
14.50 – 15.35 The price of life
15.35 – 16.00 Coffee
16.00 – 16.45 So much for that
16.45 – 17.30 Treatment, medicine and compassion
About Medicine Unboxed.
Medicine Unboxed is a unique project and conference programme that engages both the public and front-line NHS staff with a view of medicine that is infused and elaborated by the humanities. Contributors include artists, writers, the clergy, poets, philosophers, lawyers, linguists, musicians, theatre, ethicists, academics and doctors. The results are thought-provoking, inspiring, sometimes funny and often moving.

domain: medical


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six couteaux > HIGH-TECH Claude Dozorme Le Thiers knives, Box 6 Le Thiers steak knives
HIGH-TECH Claude Dozorme Le Thiers knives
Box 6 Le Thiers steak knives
Founded in Thiers, the French cutlery capital located in the heart of the Auvergne volcanic region, the Claude Dozorme company has been innovating for 100 years. Claude Dozorme, a genuine pioneer both in terms of product ranges and manufacturing techniques, is now officially recognised as a Master Cutler. Backing up the Claude Dozorme brand is a family business founded in 1902 on a passion for cutlery and the decorative arts. After carefully selecting the best materials and training his employees in manufacturing techniques both ancestral and avant-garde, Claude Dozorme designs and produces his range of knives by subtly combining traditional and contemporary features. Claude Dozorme´s high added-value products capture the essence of their region and country, long known for the culinary arts. Hawing a Claude Dozorme knife means owning a little piece of France, of the Auvergne and its art of living.
made in France
Gift box 6 stainless steel LE THIERS High-Tech steak knives Claude Dozorme with GREY aluminum handle


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In perhaps one of the most bizarre car accidents of the festive season, a Chinese Mercedes driver is understood to have “crashed violently” into the car of a Portuguese woman, and then abandoned the scene on foot – leaving not only his victim lying injured in the street, but a terrified child left behind in his car.
The extraordinary alleged behaviour was compounded by the fact that shortly after the accident a Chinese woman is understood to have turned up – not to rescue the child left behind, but to “try and remove the documents of the car”.
According to the Portuguese victim’s son however, the Chinese woman was thwarted in her mission as the PSP moved in.
The less-than-exemplary story took place on the night of New Year’s Eve in Vila do Conde shortly after restaurant owner Helena Carvalho got into her car and drove away “to collect a friend”.
She had travelled “just a few years down the road” from the restaurant in her Peugeot when it was “hit by a Mercedes” that had “not respected a stop sign” and was trying to enter Bento de Freitas avenue “on the wrong side of the road”, claims national tabloid Correio da Manhã.
Carvalho’s son Vítor arrived at the scene shortly afterwards and told the paper:
“My mother was in shock. She had summoned up the strength to get out of the car, but then she fainted, and the man ran off. The son, who seemed to be about 13 or 14 years old, wasn’t even able to talk he was in such panic.
“Then a Chinese woman appeared and, from what I could gather, tried to remove the Mercedes’ documents. The PSP had to intervene”, he added.
His mother, meantime, was taken to hospital and given the all-clear to leave a few hours later.
TWENTY SIX ROAD DEATHS IN TOTAL SINCE START OF FESTIVE SEASON
As the holidays are finally behind us, the dismal litany of accidents, severe injuries and road deaths is being totted up, with CM suggesting “at least 26 people” have been killed since December 15, the time from which traffic police up their habitual level of roadside vigilance.
Operation Tranquil Christmas was thus anything but tranquil and figures this year suggest accident levels are up on 2014.

domain: news


A United Nations committee has signaled support for an effort to help developing countries tax tech giants, but final approval will likely wait until 2021.
The U.N.'s Tax Committee of Experts, which has been in discussions over two weeks, voted 12-10 Oct. 23 to include an amendment, known as Article 12B, to its model treaty. But the committee is expected to wait on final approval to give opposing countries time to draft language that outlines their objections in the finished version, two sources familiar with the discussion told Bloomberg Tax Tuesday.
Advocates have warned that developing countries don’t have a big enough role in an OECD-led effort to get nearly 140 countries to overhaul how the digital economy is taxed. Article 12B’s backers say the amendment addresses concerns that the countries don’t have the resources to handle complex tax disputes with multinationals and bigger countries that have more resources and experience. The amendment is a simpler alternative to the Organization for Economic Cooperation and Development’s plan, they say.
But critics of Article 12B have argued that the U.N. approach could add to the division over how to tax the digital revenue of tech companies such as Facebook Inc. and Amazon.com Inc. A growing number of countries are pursuing unilateral measures, sparking trade threats from the U.S.
The committee is to continue discussions Wednesday. The U.N. didn’t immediately return a request for comment.
The U.N. approach focuses on the taxation of digital companies, while the OECD’s plan would apply more broadly—including a global minimum tax that could affect multinationals in any industry, and a plan to reallocate more profits to countries where companies have consumers or users, which may apply to large, profitable consumer-facing businesses.
—With assistance from Isabel Gottlieb.


text:
Palestinian youths sculpt the number 2022 in the sand at sunset ahead of new year s eve, at the beach in the coastal Mediterranean city of Gaza, on December 28, 2021. AFP
In a report titled “Hate Speech and Apartheid in the Occupied Palestinian Territories” issued Thursday, the ECHRD stated that hate speech against Palestinians is rooted in racist Israeli educational curriculum and news media that is responsible for implanting hatred since childhood on.
The report also stated that the expansionist settlement policy has resulted in the Palestinians being subjected to discriminatory apartheid laws favouring Jewish settlers.
“Most of those who live in the settlements are from extremist Jewish groups that advocate the Jewishness of the state and play a role in provoking and inflaming the feelings of Palestinians with open hate speech and incitement to violence against them,” according to the report.
The report also referred to the increasing international recognition of the state of affairs in the occupied territories, which invites parallels to other historical cases of apartheid.
“In recent years, there has been a noticeable increase in condemnation (within the international political discourse) of the apartheid regime, which was associated with the settlement regime in South Africa and ended in 1994... As a result of the control tools used by Israel in the occupied territories of 1967, there has been a political and geographical reality based on ethnic and hierarchical segregation in parallel with the ongoing Judaisation,” the report stated.
The report mentioned the corrosive long-term harm of such a project, saying “The government does not care about the dangerous political and moral effects of the settlements project, nor the systematic violations of human rights of the Palestinians who have been under Israeli military rule for fifty years.”
Moreover, the Israeli leadership is not interested in the presence of two judicial systems in the occupied territories, one for the Palestinians and the other for Israelis. This trend has led to a flood of bills proposing direct or indirect annexation, culminating in the enactment of the 2016 settlements law.
The report concluded Israel cannot be considered a democratic country as it is enshrining racial segregation and discrimination in law. Instead, the government is consolidating a racist colonial legacy through ethnic cleansing and the deliberate denial of the rights of indigenous peoples on their historical land, including their their historical right to their land and property.

domain: sociology


Raspberry Pi Geek Loves (open)(S)US(E)
The following article has been contributed by Dmitri Popov, Technical Writer at the SUSE Documentation Team.
Good news for those who are interested in running openSUSE and SUSE Linux Enterprise Server on a Raspberry Pi. Issue #21 of the Raspberry Pi Geek magazine already introduced openSUSE Leap 42.2 by providing it as cover DVD and via an overview article from Swapnil Bhartiya.
Issue #22 now features two full-length articles that can help you to get the most out of openSUSE and put a SUSE-powered Raspberry Pi to some practical uses.
The first article offers an in-depth description of how to use YaST to transform a Raspberry Pi into a file server that supports the NFS, Samba, and FTP protocols. Usually deploying NFS, Samba, and other servers requires some command-line wizardry.
YaST reduces the entire deployment process to a few simple steps that can be completed from the comfort of a graphical interface. The article introduces you to the magic of YaST and demonstrates how to use this powerful tool to deploy various servers on Raspberry Pi.
Thinking about turning a Raspberry Pi into a video-conferencing platform? The second article, entitled Private Chats, explains in great detail how to install and configure the Jangouts software on a Raspberry Pi running either openSUSE or SUSE Linux Enterprise Server.
In case you wonder, Jangouts is an open source drop-in replacement for Google Hangouts built by SUSE Linux developers in the course of several Hack Weeks.
Both articles are written by technical writers from SUSE Linux GmbH, so you’re getting practical advice straight from the horse’s mouth.
In short, if you want to get the most out of openSUSE or SUSE Linux Enterprise Server running on a Raspberry Pi, you wouldn’t want to miss the latest issue of Raspberry Pi Geek.
We give away a few copies of the magazine, so leave a comment if you want one. First come, first serve, while supplies last, etc., etc.
Editor’s note: If you want to try out SUSE Linux Enterprise Server on Raspberry Pi 3 yourself, read the SUSE Best Practices “Introduction to SUSE Linux Enterprise Server on the Raspberry Pi”. And if you want to play around with openSUSE on the Raspberry Pi, just have a look at Dmitri’s previous blog post “From Zero to Functional System in a Few Easy Steps”.
Great to see how openSUSE hackers are doing great things! 🙂
Can I get one of those issue to read the articles?
Maybe I can go with a translation somethig similar what I did before (https://www.suse.com/communities/blog/opensuse-raspberry-pi-3-zero-functional-system-easy-steps/)
Hi victorhck, thanks for your comment – of course you can get one of the magazines – just send your shipping address to firstname.lastname@example.org :-). And yes, feel free to translate the blog entry from Dmitri for your Spanish blog!
thanks a lot!! 🙂
Geeko started the week reading about openSUSE hacking in a Raspberry Pi device with YaST and Jangouts! 🙂
Well, in order to boost this in France, I will attempt some translation because our members would love an article in their mother tongue.
that would be marvelous! Let us know when it is done, and we will help spread the word!
Thanks very much!
Do you have a PDF or something? email@example.com (as my firstname.lastname@example.org is KO) so that I can refer to…
Hi Jimmy – unfortunately RasPi Geek mag does not provide us PDFs (they make you pay for them). But if you send me your address to email@example.com, I can send you a hard copy of the entire magazine.
Thanks – Meike
Looks like an interesting read. Would you send me a copy?
of course we can send you a copy! Would you please just send me your shipping address to firstname.lastname@example.org?
This sounds awesome, love that you guys really support EVERY hardware platform imaginable. Quantum computers? SuSE will be there first/best/longest.


text: On the evening of September 26, 1998, the T/V Command left San Francisco Bay bound for Panama. As it traveled in the southbound traffic lane off San Francisco and San Mateo County coasts, it released an estimated 3,000 gallons of Intermediate Bunker Fuel (IBF) 380, also known as Fuel Oil No.6. Due to light winds and fair weather, the oil moved little in the first few days, primarily staying in the vicinity of the southbound traffic lane. On September 30, oil began to wash ashore, largely in the form of scattered tarballs, over 15 miles of beaches, primarily in San Mateo County. A tarball sample collected as far away as the Salinas River mouth in Monterey County, however, matched the source sample from the tanker.

domain: geography


Narrow year range (drag arrows to filter):
After the introduction of the turbocharged 4-cylinder engine in the xDrive28i last year, there is little change in the line for 2014. The Technology Package now includes USB connectivity and Bluetooth with smartphone integration. The Navigation/iDrive system gets some further refinements. Some packages and availability are shuffled.
2013 sees the introduction of a turbocharged 4-cylinder engine that replaces the naturally aspirated (non-turbo) inline-6 in past xDrive28i models. Although this engine is smaller, it creates the same amount of horsepower and more torque than the former 6-cylinder engine, while attaining better fuel economy: up to 28 mpg on the highway.
BMW doesn't really want you to think of its X3 as an SUV. The German automaker calls its 5-passenger compact sport-utility vehicle a "sports-activity vehicle." You may sneer at the marketing-speak, but there is substance behind the hype. In a segment that has grown since the X3's introduction in 2004 with an onslaught of luxury rivals like the Mercedes-Benz GLK, Audi Q5, Acura RDX, Cadillac SRX and Infiniti EX, the X3 stands out with a dynamic nature that makes it feel more like a sports sedan than a cumbersome SUV. The 2014 X3 is also fuel-efficient thanks to the turbocharged 4-cylinder engine standard in the xDrive28i model. For those who want more power, a turbo 6-cylinder comes in the xDrive35i.


text:
Harvey Norman’s half-yearly results released yesterday recorded a 36.5% fall in the retailer’s net profit to $81.9 million to December 31 but chairman Gerry Harvey is still talking up the business.
Excluding the effect of new stores and store closures, Harvey Norman’s sales in the period dropped by 5.3% and the retailer was forced to increase tactical support to franchisees by $18.5 million to $68.3 million to keep struggling stores afloat.
Harvey was keen to focus instead on the retailer’s 4.1% jump in overall sales across Australia in January, with global sales up 3.8%.
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”Consumer confidence levels have risen recently and, because of that, you’ve now got weekly sales in January and February exceeding last year,” Harvey said.
”For the first time in a very long time, we now have sales that are up. That’s lifted the morale here somewhat.”
Harvey said he expects margin pressures to ease as more retailers shut up shop due to tough trading conditions and he wants Harvey Norman to be the “last man standing” in consumer electronics and whitegoods.
”You’ve had so many retailers go out of business in the last couple of years and there’s probably more to go,” he said.
Asked what he planned to do to sustain the positive figures, Harvey said: “Pray. It might have more effect than anything else”.
Shares in Harvey Norman rose 21¢, or 9.21%, to $2.49 on Thursday on the basis of the January figures.
But David Gordon, executive director of corporate advisory at Bentleys in Melbourne, told SmartCompany Harvey’s focus on one month was not a true indication of Harvey Norman’s performance.
“He’s talking up January, he’s talking up the fact his assets are up, everybody knows Harvey Norman’s property base is a strong asset, but the business is underpinned by the future cashflow,” Gordon says.
Gordon is concerned about a lack of innovation internally at the retailer.
“Harvey Norman seems to be focusing on aligning its costs and inventory to changes in demand, it also seems to be dependent on improvement in the macro economic situation and in category innovation which will come from its suppliers,” he says.
“This seems to be a reactive approach and not the proactive approach one would expect from a retailer with the experience and capabilities of Harvey Norman. That’s of course easier said than done but in my mind Harvey Norman is a corporate retailer waiting, as corporates do, for something else to fix its demand problems.”
While Harvey famously told SmartCompany back in 2008 that online retailing “is a complete waste of time”, Gordon says Harvey Norman’s omni-channel strategy is one bright spot for the retailer.
“Harvey Norman’s internet site is finally almost there and it is certainly more effective and comprehensive than most of their competitors’ sites,” he says.


text:
Of course, it's not always easy to find—or afford—organic produce. But in general, conventionally grown items that you peel—avocado, grapefruit, bananas—are fine. But choose organic when buying celery, peaches, strawberries, apples, blueberries, nectarines, sweet bell peppers, spinach, kale and collard greens, cherries, potatoes, and imported grapes; they tend to have the highest levels of pesticides.
Interval Training: A great way to incorporate high-intensity training without doing it continuously is by doing intervals. Alternate a hard segment (e.g., running at a fast pace for 30 to 60 seconds) with a recovery segment (e.g., walking for one to two minutes). Repeat this series for the length of the workout, usually around 20 to 30 minutes. A 30-60-90 interval workout is a good example of this kind of high-intensity workout.
Fitness and lifestyle coach Marci Nevin (@marcinevin on Instagram) posted nine simple, easy-to-follow eating tips to lose fat without the tediousness of having to count calories. She said that while counting calories ensures more accuracy in knowing if you're reaching your calorie goal, calorie counting isn't for everyone. Here's how you can still shed body fat "without meticulously counting every calorie."
If you could only be a fly on the wall in our kitchen each night after dinner. We are both on My Fitness Pal planning our food for the next day and weighing and measuring our portions. It is fun to meal plan together. I make the meal plan on Sunday and my hubby prepares the majority of the food. Firemen sure do know how to cook! Maybe that is why I married him.
Eat small meals more often. In simple terms, eating spurs your metabolism — the process by which your body turns food into energy. Eating more often, then, may kick your metabolism into a higher gear more times per day (e.g., if you eat six times a day, you get six “spikes”). But, you must make sure that eating more often does not also mean eating more; it’s essential that you reduce your overall average daily calories.
Suspect you have a sluggish metabolism? You might have hypothyroidism, or an underactive thyroid gland, which afflicts about 25 percent of American women — many of whom don't know they have the condition, according to the American Association of Clinical Endocrinologists. "The thyroid gland controls your body's metabolism, so one of the first signs that it may be off is an inability to lose weight," explains Pamela Peeke, M.D., professor of medicine at the University of Maryland and author of Fight Fat After Forty. Your doctor can determine if you're suffering from hypothyroidism by running a blood test. If you do have an underactive thyroid, you'll be treated with a synthetic thyroid supplement, which you will need to take for the rest of your life (it will return your metabolism to normal, so it should be easier to drop unwanted pounds).
Nuts are an excellent way to curb hunger between meals. They're high in protein, fiber, and heart-healthy fats. Studies suggest nuts can promote weight loss and improve cholesterol levels when eaten in moderation. They're also rich in calories, so limit your portions. If you have to get them out of their shell, you'll slow down and not eat as much.
A recent study in the journal Nature found that mice who were fed a breakfast in which 45 percent of the calories came from fat tended to burn more body fat over the next 24 hours than those who ate a meal that was only 20 percent fat. This is early research—it needs to be repeated in humans—but mono and polyunsaturated fats like those found in avocados and nuts do have plenty of health benefits when you eat them in moderation.
Going for a jog before a night out is a great way to crush calories, but if you strength train, you’ll continue to fry fat post-workout. To maximize the afterburn, do “weight-bearing exercises involving the most muscle mass,” such as mountain climbers, push-ups, and lunges, advises Len Kravitz, PhD, program coordinator of exercise science at the University of New Mexico.
Social conditions such as poverty, social isolation and inability to get or prepare preferred foods can cause unintentional weight loss, and this may be particularly common in older people. Nutrient intake can also be affected by culture, family and belief systems. Ill-fitting dentures and other dental or oral health problems can also affect adequacy of nutrition.
Research has shown that a large rush of amino acids into the blood stream post training will increase protein synthesis far greater than a steady flow of amino acids. This simply means that a fast digesting protein builds more muscle in the post workout state than a more slowly digested protein. For this purpose nothing beats whey protein. Whey protein is the fastest digesting protein there is, this should be your protein of choice for you post training shake.
Since it was established in 1994, The National Weight Control Registry (NWCR) in the United States, has tracked over 10,000 individuals who have lost significant amounts of weight and kept it off for long periods of time. The study has found that participants who’ve been successful in maintaining their weight loss share some common strategies. Whatever diet you use to lose weight in the first place, adopting these habits may help you to keep it off:
GH not only increases fat-burning but is required to build mass and strengthen the immune system. Yet carbs put a damper on GH release, so it's ideal to go to bed under one of two scenarios: on an empty stomach, or, even better, having consumed only protein, no carbs. This allows blood glucose—the high-tech name for digested carbs circulating in the blood—to remain low, which facilitates the rise in nocturnal GH production.
A calorie isn’t always a calorie. Eating 100 calories of high fructose corn syrup, for example, can have a different effect on your body than eating 100 calories of broccoli. The trick for sustained weight loss is to ditch the foods that are packed with calories but don’t make you feel full (like candy) and replace them with foods that fill you up without being loaded with calories (like vegetables).
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Do this: Fifteen to 30 minutes (or less) before training, consume 20g of protein powder in a whey shake or other protein powder source and 30-40g of carbohydrates to help you train hard all the way through your workout. Stick with slow-digesting carbs here, such as oat bran, oatmeal, rye or whole-wheat bread, fruit, or sweet potatoes. On nonworkout days, eat that meal as a snack and drop your post-workout feeding.
Add resistance training. A 2006 study published in the International Journal of Sport Nutrition and Exercise Metabolism suggests that combining cardiovascular (aerobic) exercise with resistance training is more effective than cardiovascular training alone in getting rid of abdominal fat. You can do resistance training with free weights, exercise machines or resistance bands and it may also be useful to train from unstable positions due to increased muscle activity.
Rather than a long and low-intensity cardio workout, try the HIIT method of cardio: intense, fast-paced intervals that leave you completely exhausted after only a 20- to 30-minute session. This form of cardio training increases the afterburn effect, allowing your body to continue burning calories long after your workout is over. You can rotate between 30 seconds of your favorite exercises, with rest in between, as long as they work different muscle groups—such as squats, push-ups and kettlebell swings.
Saturated fats in food will pack on more visceral fat than polyunsaturated ones, according to a 2014 Swedish study. When subjects ate 750 more calories daily for seven weeks, either in the form of palm oil (saturated) or sunflower oil (polyunsaturated), the former gained more visceral fat while the latter gained more muscle mass and less body fat. The study authors believe different fat types can impact both the way your body forms fat and stores it. What’s more, including healthy fats in your meals can make them more satiating and keeps hunger at bay.
Açai berry powder is high in anthrocyanin- a natural pigment providing powerful antioxidants. Açai provides an array of minerals that help to keep your body healthy and gives you high levels of sustainable energy. This extra energy will enable you to get out and exercise more, therefore extra calories will be burned and eventually the fat will come off your tummy!
There are a variety of definitions of what moderate-intensity exercise is, but it typically falls between about 70 to 80 percent of your maximum heart rate, which would be a level 4 to 6 on a 10-point perceived exertion scale. That means you are breathing harder than normal but can carry on a conversation without much difficulty and you feel pretty comfortable with what you're doing. The American College of Sports Medicine (ACSM) often recommends this level of intensity in its exercise guidelines. The lower end of this range usually incorporates the fat burning zone.
Nuts. It’s very easy to eat until the nuts are gone, regardless of how full you are. A tip: According to science, salted nuts are harder to stop eating than unsalted nuts. Salted nuts tempt you to more overeating. Good to know. Another tip: Avoid bringing the entire bag to the couch, preferably choose a small bowl instead. I often eat all the nuts in front of me, whether I’m hungry or not.
According to a small study published in the journal Annals of Internal Medicine, people who slept for 8.5 hours a night for two weeks lost nearly twice as much weight on average than participants who slept 5.5 hours per night, despite the fact that they followed the same diet and workout plan. That's because when you get a good night's sleep, your hunger hormones, like ghrelin and leptin, stay in check. That means you're not going to wake up with a sudden hankering for a bacon, egg, and cheese. (Start working towards your goals with Women's Health's Body Clock Diet.)
Spending your lunch break outside or taking a quick walk during your workday will make a huge difference. Taking 10-20 minutes in the sunshine mostly unprotected (but always protecting your face) will help to naturally boost your body’s vitamin D levels. There are so many benefits of Vitamin D – it will boost your immune system, energy levels, and overall mood!
I just finished my first round of the FWTFL and I could not be more pleased with my transformation....emotionally, mentally and physically. This is the first time since I was 16 that I have felt true freedom and enjoyment with food. I have embraced the intermittent fasting and carb cycling lifestyle and I just can't imagine doing anything else. I was desperate for something sustainable...something that taught me how to eat and enjoy REAL food ( not rely on shakes or bars)...something that would help me maximize my time at the gym. This program has encompassed everything that I needed and some stuff I didn't realize I needed :)
Fast forward to our second wedding (we were both previously married to less than fit minded partners), two new jobs, new city, new house, new life - racing took a back burner but Lee and I continued to run together, swim occasionally and he finally took up cycling. We would go to the gym together or separate so I could body pump or spin, and I picked up barre, but the nutrition was waning since my mind thought I was still on a pass but my body wasn't agreeing. 3 years after working from home and a reduced "training" schedule, half my wardrobe no longer fit. A clear sign something needed to change. Add on turning 39 and that photo from our first 1/2 marathon that kept reminding me we needed to shape up.
Carbohydrates also regulate muscle cell volume. You will notice that when carb intake is low your muscles will appear flat and smaller, because cell volume is diminished when carbs are restricted. This is because carbs are stored in muscle tissue as glycogen. Every gram of glycogen is stored with 2.7 grams of water. This can drastically effect the size of muscle cells.
How to make perfect baked chicken: Season one chicken breast with salt and pepper on both sides. Heat 1 tablespoon coconut oil in a cast iron skillet over high heat. When it starts to smoke, remove pan from heat and add chicken to hot pan. Add pan back to flame, reducing heat to medium-high. Cook for 2-3 minutes without moving to sear the chicken. Flip breast over and cook uncovered for an additional 2-3 minutes. Place the entire pan into a 350˚F oven for 8 minutes. Remove from oven and let sit in pan for 2-3 minutes before serving.

domain: health


Made from our fabulous selection of faux furs, these pillows are so soft and luxurious you'll want to decorate your whole house with them! Dry cleaning is recommended for best results, but may be washed on the gentle cycle and dried on extra-low, in a high efficiency dryer (recommended).
Sham Fabric - 100% Polyester Faux Fur. Dry-clean or hand wash gentle cycle, dry extra low heat.
Pillow Form - Spot Clean
Cover - 65% Polyester/35% Cotton
Filling - 100% Polyester
Color matching is close but not exact, dye lots may change throughout the season, please call for swatches if matching.


text:
buy morphine online
buy morphine online/ Morphine is used to relieve severe pain, such as pain caused by a major trauma or surgery, labour pain in childbirth or cancer pain.
in addition, it should only be used where other forms of pain relief have not been successful in managing pain or are not tolerated.
How does morphine work?
Morphine works directly on opioid receptors in the central nervous system, and reduces feelings of pain by interrupting the way nerves signal pain between the brain and the body.
also, It is available in tablet, capsule, granule, oral liquid and injection formulations.
What are the possible side effects of taking morphine?
All opioids, including morphine, can have side effects that include life-threatening breathing problems. The risk of these is higher:
- when first taking morphine
- after a dosage increase
- if you are older
- if you have an existing lung problem
Other side effects of morphine are similar to those of other opioids, and include:
- bradycardia (slow heart rate)
- low blood pressure
- nausea, vomiting
- dilated or ‘pin-point’ pupils
- slow, shallow breathing
Morphine affects everyone differently, so if your pain is not well managed while taking morphine, or if you notice morphine is making you feel unwell, speak with your pharmacist or doctor.
Always take medicines exactly as prescribed by your doctor.


The Covid 19 pandemic has caused significant financial distress for small and large businesses around the world, including Cambodia.
Hundreds of factories, hotels, restaurants and other businesses have closed or been at the brink of closure. They are facing bankruptcy with little hope of survival.
In this time of economic turbulence, the bankruptcy law plays a very crucial function in resolving legal conflicts and reducing social and economic problems. The authorities need to pay urgent attention to the implementation of this law.
However, Cambodia’s bankruptcy law which was promulgated in 2007 is little known to the public and business community as it has rarely been used.
Key objectives and social roles of bankruptcy law
The bankruptcy law has two main objectives – to provide collective, orderly and fair satisfaction of creditors’ claims out of a debtor’s estate, and to rehabilitate the business of the debtor.
Its first objective – the collective, orderly and fair satisfaction of claims from the creditor – is a “distributive” function.
The bankruptcy law provides for rules, conditions, procedures, and a process for distributing the properties of the debtor to satisfy the creditors’ claims.
The law ensures fairness and lawfulness in distributing the debtors’ assets to prevent and terminate conflicts between creditors and creditors, or creditors against the debtor. It is the economic role of the law to ensure fair play in the market system.
In its second objective to rehabilitate the debtor’s business, the law offers a chance to the debtor or administrator to propose a plan to either reorganise the business or compromise with creditors.
In this plan, the debtor or administrator may propose to creditors to write off certain debts and/or defer the repayment schedules.
The compromise plan which is approved by the creditor and the court would allow the business to continue operating concurrently with debt repayments so that the business may survive.
The bankruptcy law’s fundamental goal is to give the debtor a fresh start from burdensome financial debts.
It’s like “giving to the honest but unfortunate debtor a new opportunity in life and a clear field for future efforts, unhampered by the pressure and discouragement of pre-existing debts”.
To put it simply, the bankruptcy law prevents social drama because an excessive debt trap would put the debtor and his relatives into extreme poverty. It also ensures that creditors’ interests are fairly satisfied.
A lot of Cambodians believe in karma. They would try their best to honour and repay their debts no matter what happens to them.
They sell lands, houses and whatever properties they have. Parents are keen to pay for their children’s debt or vice versa, until they are left in extreme poverty.
Struggling to overcome debt causes emotional stress and consequently harms the physical health of debtors.
A depressed debtor may choose to commit suicide to release him or her from existing debts, and this needs to be avoided, which is another reason for leveraging on the bankruptcy law.
Debtors who encounter misfortune may end up trapped in heavy borrowings with exorbitant interest rates and penalties from both formal and informal lenders.
The failure of their businesses and inability to repay the debts may be caused by an unpredictable economic downturn. In this situation, the bankruptcy law could be used as a social legislation to help such unfortunate people, whether they are businessmen or individuals.
Applying for bankruptcy proceedings
The bankruptcy law applies to both individual merchants and business organisations, including partnership and limited companies.
An exception is made for those business entities covered by the law on banking and financial institutions, the law on insurance, and law on non-government securities.
A petition to begin a bankruptcy proceeding can be filed by a debtor, one or more creditors, or a public prosecutor. A debtor is a natural person or legal entity that is insolvent.
A creditor means any natural person or legal entity that owns a claim against the debtor or estates of the debtor. If the debtor is a legal entity, the director of the company is entitled to file the petition to start bankruptcy proceedings.
Requirements to apply for bankruptcy
The failure of a debtor to meet one or more valid and mature obligations to pay an aggregate amount in excess of 5,000,000 riel (US$1,250) is a ground to start bankruptcy proceedings with respect to the debtor. The Minister of Justice may change the minimum amount of such obligation.
The petition to begin bankruptcy proceedings shall state the name and address of the debtor and petitioner, grounds for the petition, list of creditors (if the petition is filed by the debtor) and description of the circumstances showing the existence of such ground(s).
It must also have as attachments, any evidence or documents to substantiate the petition.
The petition shall be submitted to a competent court located at the domicile of the debtor or the registered office of the legal entity or its place of business or at the location of their assets.
After a hearing, if the court is satisfied with the grounds of the petition, it will issue a written ruling to begin bankruptcy proceedings against the debtor.
The examination of the petition, payment of court fees and security requirement shall be determined by the court according to the provision of the code of civil procedure.
If the court decides to open the bankruptcy proceedings and to appoint an administrator, his fees and expenses shall be paid from the estates of the debtor as part of admissible claims, taking into account the amount of time the administrator spent to perform his duties, the value of the estate of the debtor, and the scope and complexity of the bankruptcy proceeding.
Application to begin bankruptcy proceedings
If the petition to begin bankruptcy proceedings is filed by the debtor, the court shall hear the petition as soon as possible and in any event, no later than 15 days from the date of filing the case.
If the petition is filed by a creditor or director of a company or public prosecutor, the court shall hear the petition no later than 30 days after it is filed.
The announcement of the ruling shall be made no later than 14 days after it is heard. This ruling can be appealed by a debtor or creditor within seven days after the issuance of the ruling.
In the ruling to begin bankruptcy proceedings, the court shall also announce the date to convene the creditors’ meeting, which shall be between at least 30 days and no more than 60 days of beginning bankruptcy proceedings.
The submission of claims by creditors shall also be done seven days before the date of the creditors’ meeting.
The time required for completing a bankruptcy proceeding depends on whether there is a compromise or rehabilitation plan, or complexity of proceedings for disposal of the estate and the satisfaction of admissible claims.
Claims in a bankruptcy proceedings
A claim is defined as any right to receive payment from the debtor or from assets of the debtor which arose before the opening of insolvency proceedings, regardless of whether such claims are conditional, unliquidated, or contingent.
The claims could be classified into admissible, inadmissible and administrative claims. The administrative claims include the remuneration, fees and expenses of the administrator.
Inadmissible claims include interest accruing on claims from the date of beginning bankruptcy proceedings, costs incurred by creditors for participating in the bankruptcy proceedings, fines, administrative penalties and other incidental legal consequences which obliges the debtor to pay, etc.
Effects of the bankruptcy proceedings
After the beginning of bankruptcy proceedings until its termination by the court, no action, proceeding, execution of process or any other action of any kind by or on behalf of a creditor can be commenced or continued against the debtor or the debtor’s assets.
This means all legal actions against the debtor shall be stayed.
The management and power over all assets of the debtor shall be vested in the administrator appointed by the court.
The administrator shall obtain consent from the creditors to sell any real property, transfer any part of assets of a related party, or carry out any transaction that would irreversibly preclude the proposal, approval or implementation of a plan of compromise.
The administrator may elect to continue the performance of a contract between the debtor and a counterparty which has not been fully performed by the debtor and the counterparty before the beginning of bankruptcy proceedings.
The proceeds of the liquidation of the debtor’s assets will be used to satisfy admissible and administrative claims in order of priority.
The payment of employee wages, administrator’s remuneration, administrative fees and court fees are a top priority.
After this, the proceeds are used to settle secured claims, government taxes which have not been filed, and all other admissible unsecured claims. Any proceeds left undistributed after the satisfaction of all claims are returned to the debtor.
Punishment for failing to file for bankruptcy
A debtor that has ceased to meet its mature and valid obligations to pay debts of 5,000,000 riel or more shall file a petition to begin bankruptcy proceedings.
In case of a partnership or limited company, each individual director, partner, or manager as the case may be, shall ensure that the petition is filed in a timely fashion.
Any person who intentionally or negligently fails to file a petition shall be personally liable to the debtor’s creditor or creditors for damages that result directly from such failure.
If such duty falls on more than one person, all such persons shall be jointly and severally liable for such damages.
Despite such functions of the bankruptcy law, it has been little used by merchants, businesses, lawyers and other stakeholders in Cambodia.
So far, there have been less than a dozen bankruptcy cases filed in competent courts. The experience has shown limited success due to the inefficiency of the bankruptcy process, insufficient trust in the court process, and lack of knowledge of the bankruptcy law.
The bankruptcy law empowers the Minister of Justice to issue a number of regulations to implement it, including determining the qualifications, roles and powers of the administrator, setting the minimum obligations as grounds to begin insolvency proceedings, and fixing the rate of remuneration and expenses of the administrator etc.
Nevertheless, none of these regulations has been issued since 2007.
So far, there are a dozen administrators accredited by the Minister of Justice to undertake bankruptcy work.
To effectively implement the bankruptcy law, the ministries of Justice and Commerce should work closely to issue relevant regulations to ensure an efficient and simplified bankruptcy process and to raise more awareness among the public and business community.
Moreover, they should also speed up the operation of the Commercial Court at each court of first instance by putting in place expedited proceedings to resolve commercial conflict.
In my experience, it is far more complicated and time-consuming to liquidate and close businesses than to register one in Cambodia.
Some have chosen to remain silent and leave the business to die, rather than go through bankruptcy proceedings due to the complexity, uncertainty and inefficiency of the bankruptcy process.
Consequently, the bankruptcy law has not been sufficiently used to serve its legal, social and economic objectives. This urgently needs to change.
The author is the managing partner of HBS Law Firm and Notaries. He welcomes your comments and can be reached at: [email protected] The above views are that of the author and intended purely as general information only. The Post shall not be held responsible for any unintended damages suffered because of the views expressed in this article.


text: Objective The administration of glucocorticoids usually causes a minor upsurge in fasting sugar levels and a larger dose-dependent upsurge in postprandial values in patients without pre-existing diabetes mellitus. or various other illnesses with renal participation had been recruited for today’s retrospective research. After beginning DPP-4 inhibitors, the indicate and regular deviation (SD) from the blood sugar level, as well as the indicate amplitude of glycemic excursion (MAGE) had been significantly improved compared to baseline. Furthermore, the region within the curve (AOC) for the sugar levels 70 mg/dL had not been increased compared to baseline following the initiation of DPP-4 inhibitor treatment. The outcomes indicate that the treating sufferers with glucocorticoid-induced diabetes using DPP-4 inhibitors can prevent hypoglycemia and decrease blood sugar variability. Bottom line DPP-4 inhibitors are possibly useful for blood sugar control in sufferers with glucocorticoid-induced diabetes. solid course=”kwd-title” Keywords: dipeptidyl peptidase-4 inhibitor, glucocorticoid-induced diabetes, constant blood sugar monitoring Launch The administration of glucocorticoids generally causes a light upsurge in fasting sugar levels. Glucocorticoids also induce a dose-dependent upsurge in postprandial blood sugar levels, also in sufferers without pre-existing diabetes mellitus. The system where glucocorticoids trigger hyperglycemia is normally multifactorial and contains the enhancement of hepatic gluconeogenesis, the incorrect secretion of glucagon, the inhibition from the blood sugar VX-661 manufacture uptake in adipose tissues, as well as the alteration of insulin receptor and post-receptor indicators (1-4). Sufferers with consistent hyperglycemia because of glucocorticoid therapy occasionally need insulin therapy. Actually, insulin therapy is preferred for sufferers with glucocorticoid-induced diabetes with the Endocrine Culture suggestions for the administration of hyperglycemia in hospitalized sufferers (5). Nevertheless, insulin therapy itself can lead to increased putting on weight and may trigger more shows of hypoglycemia, a few of which are serious. Recent trials have got demonstrated the efficiency of thiazolidinediones and acarbose in sufferers with glucocorticoid-induced diabetes (6, 7); nevertheless, there is small evidence over the efficiency of dental hypoglycemic realtors for glucocorticoid-induced diabetes. Furthermore, if sufferers with glucocorticoid-induced diabetes may also be identified as having chronic kidney disease (CKD), the usage of oral hypoglycemic realtors such as for example sulfonylureas, biguanides, or both, is normally from the threat of developing medication-associated undesirable events such as for example extended hypoglycemia and lactic acidosis. Dipeptidyl peptidase (DPP)-4 inhibitors certainly are a brand-new class of dental antidiabetic medications that raise the action from the incretin human hormones. With dose modification, DPP-4 inhibitors may also be implemented to CKD sufferers. Furthermore, a meta-analysis by Kim et al. demonstrated that DPP-4 inhibitors are especially effective in Asian sufferers with type 2 diabetes (8). Nevertheless, there is small proof their efficiency in sufferers with glucocorticoid-induced diabetes. The complete circadian variants in the blood sugar levels of sufferers with glucocorticoid-induced diabetes never have been clarified. A continuing blood sugar monitoring (CGM) program can measure the changes within a patient’s interstitial blood sugar each day. It is extremely accurate, simple to use, and useful in the daily administration of diabetes. In today’s study, we examined the efficiency of DPP-4 inhibitors, as dependant on CGM, in the treating sufferers with glucocorticoid-induced diabetes. Components and Methods Sufferers We retrospectively examined 15 Japanese sufferers, who had been diagnosed as having glucocorticoid-induced diabetes and who had been examined by CGM on the Department of Clinical Nephrology and Rheumatology of Niigata School Medical and Teeth Hospital as well as the Department of Internal Medication in Itoigawa General Medical center, Japan, between Apr 2012 and March 2013. The analysis protocol was authorized by the human being study ethics committees at both organizations and relative to the concepts embodied in the Declaration of Helsinki, and created educated VX-661 manufacture consent was from all individuals. We excluded 2 individuals who have been finally verified to VX-661 manufacture possess type 2 diabetes: 1 individual with an unhealthy CGM documenting, and 1 individual who had just received DPP-4 inhibitor treatment for VX-661 manufacture 2 times at the next CGM check. Eleven individuals (male, n=5 feminine, n=6 mean age group, 62.211.7 years) were admitted to either from the private hospitals, mainly for kidney disease or additional diseases with renal involvement (Desk 1). These were glucocorticoid-naive and hadn’t Rabbit polyclonal to APEH previously been identified as having diabetes mellitus. In addition they fulfilled the next requirements: hemoglobin A1c (HbA1c) level 6.5 % and fasting plasma glucose level 126 mg/dL before the administration of glucocorticoid. The individuals received glucocorticoids based VX-661 manufacture on the guidelines for every fundamental disease. No individuals had a family group background of diabetes. Desk 1. Overview of Patient Features. thead design=”border-top:solid slim; border-bottom:solid slim;” th rowspan=”2″ valign=”middle” align=”middle” design=”width:4em” colspan=”1″ Case /th th rowspan=”2″ valign=”middle” align=”middle” design=”width:4em” colspan=”1″ Age group.

domain: biology


text:
Arise TV Host, Rufia Oseni, has faulted the Gabonese President Ali Bongo, over the military coup happening in the country.
Naija News reports that Gabonese citizens, unbothered about the implications of military rule, took to the streets to celebrate members of the security forces in the country after they ousted President Bongo following his re-election despite his family spending 54 years in power.
Bongo’s son and close adviser, Noureddin Bongo Valentin, his chief of staff, Ian Ghislain Ngoulou, his deputy, two other presidential advisers, and the two top officials in the ruling Gabonese Democratic Party were also arrested.
The military accused them of treason, embezzlement, corruption, and falsifying the president’s signature, among other allegations.
In a post shared on Twitter, Rufai Oseni said that if the judiciary and other African institutions are more robust, there will be fewer coups.
He noted that Ali Bongo forgot that power belongs to the people, adding that African politicians must do the will of the citizens and avoid acting like God.
He tweeted, “For politicians that act like God remember to be careful. Absolute power corrupts absolutely, Ali Bong became delusional to forget that power belongs to the people! The judiciary and other institutions in Africa must be bolstered. If we had stronger institutions, we will have less coups.
“I don’t support coups I don’t think there is legitimacy in toppling any govt through military means but our politicians must be careful and do the will of the people.”
The post ‘Ali Bongo Became Delusional To Forget That Power Belongs To The People’ – Rufai Oseni appeared first on Naija News.


Technical Agreements for Biocides 2019
Technical Agreements for Biocides 2019: What You Need to Know
Biocides play an important role in our everyday lives. From the disinfectants used to clean household surfaces to the preservatives added to our food, biocides are essential to maintaining a healthy environment. However, the use of biocides must be regulated to ensure their safety and efficacy. This is where technical agreements for biocides come in.
What are technical agreements for biocides?
Technical agreements for biocides are documents that outline the technical requirements for the approval and use of biocidal products. These agreements are designed to ensure that biocidal products are safe for human health and the environment, and that they are effective in controlling harmful organisms such as bacteria, viruses, and fungi.
The technical agreements for biocides are established by the European Union (EU) under the Biocidal Products Regulation (BPR). The BPR sets out the rules for the authorization and use of biocidal products in the EU. The technical agreements for biocides are one of the tools used to enforce these rules.
What is new in the technical agreements for biocides in 2019?
The technical agreements for biocides are updated periodically to reflect changes in scientific knowledge and regulatory requirements. In 2019, several changes were made to the technical agreements for biocides.
One of the major changes was the introduction of new requirements for efficacy testing. Biocidal products must now undergo efficacy testing against relevant microorganisms, including resistant strains and biofilms. In addition, the testing must be conducted under realistic conditions, such as those found in the intended use environment.
Another change was the introduction of new requirements for the assessment of the environmental risks associated with biocidal products. The environmental risks must be assessed using a standardized methodology that takes into account the properties of the product and the environmental conditions of the intended use.
The technical agreements for biocides also now require the submission of additional data to support the safety of biocidal products. This includes data on the toxicological properties of the active substances and the formulation of the product, as well as data on the potential for the product to accumulate in the environment.
What are the implications of these changes?
The changes to the technical agreements for biocides have important implications for manufacturers and users of biocidal products. Manufacturers will need to conduct additional testing to demonstrate the efficacy and safety of their products, and will need to submit more data to support these claims.
Users of biocidal products will need to be aware of the new requirements for efficacy testing and environmental risk assessment. They may also need to adjust their use of biocidal products to comply with any new restrictions or conditions of use that may be introduced as a result of the updated technical agreements.
In summary, the technical agreements for biocides are an important tool for ensuring the safety and efficacy of biocidal products. The 2019 updates to these agreements introduce new requirements for efficacy testing, environmental risk assessment, and data submission. Manufacturers and users of biocidal products should be aware of these changes and take steps to comply with the updated requirements.


text:
Flashcards in Absorption of Iron and GIT disease Deck (38):
What is the role of iron In human biology?
- Oxygen transport and storage
- Electron transport (oxidative phosphorylation generation of ATP involves cytochromes which are iron containing proteins)
- Plethora of enzymes, ribonucleotide reductase (rate limiting step in DNA synthesis) and RNR needs iron
- Cell cycle control, cells will die without iron
Why does iron have to be tightly regulated?
- There is no active excretory mechanism for iron, it enters the duodenum and stays in the body
- Need to tightly regulate, if body is iron rich you need to ensure no further iron is absorbed because if you continue to absorb this will be detrimental obviously
What is the process o Erythropoiesis?
- Circulating pool of iron, which is directed to the bone marrow to make more red cells
- Erythrocytes produces, then after 120 odd days they are destructed and engulfed by macrophades resulting in a plasma iron pool as iron is recycled back out of haem (haem is broken to bilirubin)
- Plasma iron pool contributes to the liver and liver to plasma iron pool
What does the iron we consume in our diet come from?
- Inorganic ion, predominately in the ferric form, Fe3+, this is poorly absorbed because it has to be reduced to ferrous and often tends to be complexed with other things in the diet that render it inert and relatively unabsorbable
- Haem, which is found in meat
- Consume 20mg but only need to absorb 1-2mg
- Mainly absorbed in duodenum
What are the proteins in iron transport?
- Inorganic iron, ferric Fe3+ will have to be reduced to ferrous iron Fe2+, this in part happens in acid by the acid in the stomac and duodenal cytochrome b
- Absorbed by divalent metal transporter 1 =, dmt1
- Once ferrous ion is in the cell it can; be used by that cell for whatever process, can be stored within the cell in ferritin which binds the iron and renders it inert so it does not drive free radicals, can be effluxed out of enterocyte into the blood via Ferroportin which is reoxideised by hephaestin and circulates around the body bound to a protein called transferrin which also renders it inert
What reduces ferric iron to ferrous iron?
- this happens in part by the acid in the stomach and duodenal cytochrome b
What changes ferrous iron to ferric iron?
How is iron stored?
Ferritin, this renders it inert so it does not drive free radicals
- free radicals can drive lipid oxidation etc
What is Ferrorportin?
- the protein that effluxes iron out of cells
What is hephaestin
- allows it to be bound to transferring
How to other cells get iron into them?
capture transferring via a transferrin receptor
cells express a transferrin receptor
How is iron transported in the blood?
How is haem transported/absorbed?
HCP1 to absorb haem
haemooxygenase 1 will then break it down into bilivirdin and free iron
How do we make haem?
What happens if there are issues with enymes involved in making haem?
can lead to porphyria which is where you have a build up of precuroses such as glycine and succinyl coa
Where is Iron stored?
liver, spleen and bone marrow
How do these stores communicate to the small intestine to tell it to stop absorbing?
- hepcidin has bacterialcidal activity
- hepcidin inhibits iron metabolism
- induced in inflammation and infection
How does hepcidin acts as an inhibitor of iron absorbtion
- Binds to ferroportin (which is the efflux protein)
- Feerroportin is an iron efflux protein, when hepcidin binds to it you lose ferrorportin expression so it cannot absorb/efflux iron
- Binds and internalises ferrorportin
What happens under high iron levels?
- You are going to want to stop other iron from being absorbed
- You will switch hepcidin on which will bind to ferror portin so no more transport through enterocyte
- High iron is sensed by proteins within the hepatocytes; TFR2, HFE and HJV
- Lots of iron, sensed by hepatocytes and proteins, so they produce hepcidin which binds to ferorportin and block iron absorbtion
What if there are too little iron levels?
What if there are too little iron levels?
- Such as anaemia or hypoxia
- You will want to stimulate more iron absorption
- You suppress hepcidin levels so it cannot stop iron efflux, and as much iron is absorbed as possible
What happens in instances of inflam/infection
- Hepcidin is induced
- When you have an infection you switch hepcidin on by stimulated IL-6
- IL-6 stimulates hepcidin translation
- Hepcidin will stop iron absorption and bind to ferrorportin on macrophages so the macrophage will become iron loaded and cant efflux the iron into the iron pool, this is because bacteria need iron, so hepcidin makes the human body limit iron and prevents bacteria from getting to iron
- Bacteria produce ciddorifors which compete for this iron
What does IL-6 do?
it stimulates hepcidin translation
What is a ciddorifor?
This is how bacteria compete for the iron
What happens if you limit the iron pool?
- You limit erythropoiesis and so develop anaemia
- In infection you may develop anaemia because the iron, as a result of hepcidin binding to the macrophage ferrorportin preventing iron efflux and locking iron in, so you have less iron in the lay iron pool for erythropoiesis by the bone marrow
- This type of anaemia is an anaemia of chronic disease, ACD
What happens in incidence of inflammation?
- Ferrous iron is toxic, so will make the inflammatory insure worse
- We induce hepcidin as a mechanism to insure the iron is not making it any worse
Why do patients with rheumatoid arthritis commonly have anaemia?
- RA is an autoimmune inflammatory disorder, inflammatory issues induce hepdicin
- Hepcidin binds to ferrorportin and switches it on resulting in less absorption of iron and locking iron away
- This results in less iron in the lay iron pool which means that it cannot be used to create more blood
- This is anaemia of chronic disease
- This is because iron is toxic and can induce free radicals and make everything worse
What happens with obese individuals and iron status?
- They have a poor functioning iron status
- Presenting with an anaemia of chronic disease
- When they lose weight iron status improves and hepcidin levels go down
What is the difference between ACD and Iron deficiency anaemia?
- You can use serum ferritin, there is circulating ferritin which is a measure of iron levels (ferritin is induced by iron) low ferritin implies iron deficient
- But ferritin is a protein so can be high not because of iron
- Low ferritin is likely to be IDA, high is likely to be ACD
What is Ferritin?
a store of iron
What happens when you cant make hepcidin?
- this is called hereditary haemochromatosis
- iron overload
What is haemochromatosis?
- Hereditary disease with improper dietary iron metabolism causing the accumulation od iron in a number of body tissues
- Iron accumulation can cause organ damage
- Treat with phlebotomy you- take away their blood, they are good donors
- Mutations in HFE rendered an individual with less hepcidin
- Mutations In TfR2 and HJV also causes it
- Subclassified depending on the type of mutation
Mutations in what genes causes herediary haematochrosis?
- Mutations in hepcidin itself
- Ferrorportin is mutated and so may be insensitive to hepcidin signalling so it is no longer turned off when hepcidin hollas at it
Why is HFE important?
- HFE is expressed when you have high iron levels
- HFE switches iron on
- A mutation in HFE means it can no longer sense a high iron so you do not switch hepcidin on!
How is iron toxic?
- It drives free radicals through fenton reactions
- Develop fibrosis, cirrhosis in the liver etc
- High risk of cancer
- Arrhythmias, diabetes
What are the common causes of IDA?
- Premenopausal women as we are losing lots of blood
- Vegan diet, iron restrictive diet and losing a reasonable amount every month
- Blood loss from GIT, such as a carcinoma or cancer or tumour or ulceration with bleeding like chronns is likely to present with an iron deficiency anaemia
What are NSAID users more likely to develop?
- they inhibit the COX pathway
Treatment strategy for IDA?
- Ascorbate, 200mg a day which is an iron formulation


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