text:
Ten-part series covering Chicago Bulls' path to 1997-98 NBA championship and career of Michael Jordan continues to draw more viewers than almost all other sports programming.
Ratings for ESPN's "The Last Dance" dipped again on Sunday, but the documentary about Michael Jordan and the 1990s Chicago Bulls continues to draw more viewers than almost all other sports programming.
The 10-part documentary series, divided into 10 one-hour episodes, chronicles the Bulls' path to the 1997-98 NBA championship.
Episodes 7 and 8 drew 5.3 million and 4.9 million viewers, respectively, on Sunday, ESPN announced on Monday.
The first six episodes were watched initially by 6.3 million, 5.8 million, 6.1 million, 5.7 million, 5.8 million and 5.2 million viewers.
The odd-numbered episodes are attracting higher viewership because they are airing at 9 pm ET, while the even-numbered episodes are airing at 10 pm ET.
Top trending topic
According to ESPN, the first eight episodes of "The Last Dance" all rank among the 10 most-viewed sports telecasts since virtually all major sports competitions shut down in mid-March due to the coronavirus pandemic.
Including people who taped the programme and watched it later, those who watched it through video on demand or those who viewed reruns, the first six episodes are now averaging 12.2 million viewers, per ESPN.
The Chicago TV market continues to produce the highest ratings for "The Last Dance," with 11.6 percent of all TV households tuning on Sunday night.
Other top-rated markets included Greensboro, NC (5.7); Raleigh-Durham (4.6) and Nashville (4.4).
For the fourth week in a row, "The Last Dance" led all TV programmes in social-media mentions, again emerging as the top trending topic on Twitter.
"The Last Dance" concludes this Sunday on ESPN and ESPN2 with Episode 9 at 9 pm ET and Episode 10 at 10 pm ET.

domain: entertainment


After announcing at the start of the episode that Lanre had agreed to leave the villa due to breaking the rules, he was edited from all footage aired on Tuesday night - except for one shot where eagle-eyed viewers spotted his arm.
"I appreciate you all and hope I provided some good, positive moments during my time on Love island and for anyone wondering I'm all good".
Viewers who tuned into Love Island in the United Kingdom last night eager to find out what villa sin led to Sherif Lanre being kicked off the show were left disappointed. Already, someone's been unceremoniously booted from the villa under mysterious circumstances - 20-year old chef Sherif Lanre.
After entering the villa and instantly dumping Sherif for Callum, she labelled her new match as "old", then rejected several other boys who tried to try it on with her after failing with their first choices, leaving her to declare that she was no one's second best.
His mother Diana has said: "I don't know the real reason yet, but I'm determined to get to the bottom of it".
"I do struggle with being open and honest about how I feel until I categorically know and I was going to pull you for a".
"But I'm his mum, I'm going to think it was a bit unfair".
Following the news of his exit from the show, his family shared a post on Instagram which has since been deleted.
"But he will STILL be appearing on our screens tonight".
He said: "In a case of poor judgement, I broke the villa rules and as a result agreed with the producers that it was best for me to leave the villa".
"Earlier today, following conversations with the producers, Sherif left the villa".
The Sun adds that producers have hired security to stop the family from speaking out, anxious that the scandal could sink the popular show, which is estimated to be worth £25m a YEAR in advertising revenue.
He continued, "I really enjoyed my time in the villa and look forward to catching up with everyone on the outside".


‘Much Higher Potential’—Elon Musk Reveals Why He’s Backing Dogecoin Over Bitcoin And Ethereum Amid Huge Crypto Price Crash
Elon Musk, the Tesla
The bitcoin price has fallen sharply over the last month, losing around 25% of its value and hitting the price of ethereum and most other major cryptocurrencies—including the meme-based dogecoin.
Musk, speaking to Time magazine after it named him Time’s 2021 Person of the Year, said he thinks dogecoin is better suited for transactions than bitcoin and has a “much higher potential.”
Sign up now for the free CryptoCodex—A daily newsletter for the crypto-curious. Helping you understand the world of bitcoin and crypto, every weekday
“Bitcoin is an interesting example and the prime mover on this,” Musk said in a video shared to Twitter by Time.
“The transaction volume of bitcoin is low and cost per transaction is high. Bitcoin is maybe suitable as a store of value but fundamentally bitcoin isn’t a good substitute for transactional currency. Even though it was created as a silly joke, dogecoin is better suited for transactions,” Musk said, explaining, “the total transaction flow that you can do with dogecoin, transactions per day, is substationally higher [than bitcoin] and it has much higher potential.”
The bitcoin price has soared over the last 12 months as traders and investors bet it will act as a hedge against the inflation created by huge government Covid-19 stimulus measures. In May 2020, famed macro investor Paul Tudor Jones made headlines when he revealed he thought bitcoin was the “fastest horse to beat inflation.”
However, Musk has said he thinks dogecoin’s inflationary nature could help it dominate the crypto payments space.
“Dogecoin is slightly inflationary but that inflationary number is a fixed number as opposed to a percentage,” Musk told Time this week. “So that means over time its percentage of inflation actually decreases. That’s actually good because it encourages people to spend rather than hoard it as a store of value.”
The massive bitcoin price rally, taking bitcoin from under $20,000 per bitcoin this time last year to highs of almost $70,000 last month, has helped the broader crypto market surge to a combined value of around $3 trillion.
Ethereum, the second-largest cryptocurrency after bitcoin, has rocketed 500% over the last 12 months, far outpacing bitcoin’s rally. Many ethereum rivals have also soared as investors bet they could win market share from ethereum.
Dogecoin, helped on by support from the likes of Musk and other high-profile investors and influencers, has climbed a blistering 5,000% over the last year—even thought the current dogecoin price is down almost 80% from its all-time high set in May ahead of Musk’s much-hyped appearance on comedy sketch show Saturday Night Live.
Since then, Musk has called on dogecoin developers to upgrade the meme-based cryptocurrency with faster transaction times and lower fees in order to “beat bitcoin hands down.”
The wider bitcoin and crypto market also remains highly volatile and has fallen sharply in recent weeks, wiping almost $1 trillion worth of value from the crypto market.


text:
Today's issue of the The New York Daily News featured Ithaca's very own Piggery. The Piggery operates a pork CSA both in Ithaca and in Brooklyn.
When I spoke to farm owner Heather Sanford a couple months ago, I asked her about marketing their heirloom pork. Why not hook up with high end chefs to get a premium price for their meat, I asked. She explained that due to the nuances of food laws and their particular certification, The Piggery can only sell direct to consumers -- hence the need to expand their CSA to the NYC region.
For more about The Piggery, check out this article in Edible Finger Lakes.

domain: news


text:
Jazz Name Former Spurs Exec New GM
If Dennis Lindsey was going to be an NBA general manger, the timing had to be right and the culture perfect.
He found that combination with the Utah Jazz, who on Tuesday introduced the former San Antonio Spurs exec as new GM. Longtime Jazz general manager Kevin O’Connor relinquished day-to-day duties with Utah but will continue to oversee basketball operations as an executive vice president.
Jazz CEO Greg Miller did not mince words in outlining his expectations for Lindsey, who spent the past five seasons in San Antonio’s front office and was Utah’s first and only choice for the job.
“I view your arrival here as a tangible step in our march toward a championship,” Miller said.


text:
Racing Horizon APKcom.RoosterGames.Racinghorizon
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domain: hobby


text:
In a rather surprising yet welcome development the government has come up with rather bullish figures on Pakistan’s economy for fiscal year 2021-22. It has taken the opposition parties by surprise who have been damning the government by presenting to the public their narrative of the messed up economy and high inflation as a single-point agenda to oust the government. The federal government last week approved an economic growth target of 4.8% and estimated inflation to remain at 8% for the next fiscal year 2021-22; its fourth year in office.
The positive development is largely attributed to the expected growth in foreign remittances, exports and manufacturing, services and agriculture sectors.
Asad Umar, the Federal Minister for Planning and Development, has spelled out the targets for the next fiscal year. The minister said foreign remittances are expected to peak to $29.3 billion in this fiscal year. The agricultural sector is expected to grow by 3.4% in the next fiscal year as against 2.8% in the ongoing one.
The services sector is projected to grow by 4.7% as against this year’s estimates of 4.4%. Industrial sector’s growth target is 6.8% compared to this year’s growth estimate of 3.6%.
Manufacturing sector’s growth target is 6.2% and large-scale manufacturing’s 6%. Electricity generation is targeted to grow by 6% next year. National savings are projected to increase to 14.2% as against 13.9% of the GDP this year. The total investment is also projected to increase to 16% of the GDP as against 15.2% this year.
The minister said the APCC had approved the current account deficit target at 0.7% of the GDP or $2.3 billion.
The government has approved exports target at $26.8 billion — higher by only $1.6 billion or 6.3% against this year’s estimated exports.
The import target is $55.3 billion — up by $4.9 billion or 9.7%. The trade deficit is projected to widen to $28.4 billion in the next fiscal year — up by $3.2 billion or 12.7%.
Considering the negative impact of Covid waves and when benchmarked to other economies around the world, the economic growth figures presented by the PTI government are impressive.
The year 2021- 22 will witness the hype of vote politics driven by the treasury and opposition benches alike. The country’s economy will be one subject which will be played around the most by both, notably, in the areas which affect the masses. The incumbent government will be dedicating the next two years of its tenure to the economy for the masses – which means managing inflation and pushing ahead its Ehsaas programme for the masses. During this phase, funds will also be doled out to legislators to enable them to come up with projects favourable to their vote bank.
Time for strategic actions like privatisation of State-Owned Enterprises (SOEs), managing circular debt by increase in utility tariffs, accountability of politicians and alike and similar measures in larger national interest is more or less over.
The new economic team has accordingly set its goals for the next two years. Its agenda is characterized by two points: (i) inflation and (ii) revenue generations to fund social programmes for the masses.
Having achieved this, the incumbent government can step into the next general elections of 2023 with better chances of success. Equally important for the government in its remaining tenure will be its resistance to the temptation of being one step ahead of the opposition in political bickering. It should spare itself and the nation the temptation of being distracted from the core target of building up the nation’s economy.
(The writer is a former President, Overseas Investors Chambers of Commerce and Industry)
Copyright Business Recorder, 2021

domain: politics


text:
Anti-Bullying Inspire Pack-Poster
Each poster measures 13 ⅜" x 19"
|Availability:||In stock (3)|
Use these motivational posters with anti-bullying quotes to help educate students about bullying and encourage them to be supportive, accepting, and respectful of their peers. These posters can be displayed in a classroom, hallway, or any other common area on a school campus to help build a safe environment where all students feel accepted! Integrate these posters into any bullying prevention program as a visual reminder to students that bullying is not tolerated.
The motivational messages on these anti-bullying posters can be used with students of any age, even on college campuses.
- Each poster measures 13 ⅜" x 19"
Pack includes 4 posters:
Be a Buddy Not a Bully
Wrong is wrong even if…
Spoken words can’t be erased

domain: sociology


Zac Brown Band takes over the top
Tuesday, August 2, 2011
– The Zac Brown Band has another number song on its hands. Knee Deep,
the song featuring Jimmy Buffett, will top the Billboard Country Songs chart when the charts are released on Thursday.
The song will assume the top spot from Tomorrow by Chris Young. Zac Brown Band now has enjoyed 7 number one songs since 2008.
More news for Zac Brown Band
CD reviews for Zac Brown Band
Jekyll + Hyde
Fans looking for the Zac Brown Band of 2005 won't find it in "Jekyll + Hyde" - there's nothing but an aftertaste of the Georgia group's chicken-fried origins. That might be why the album's name is so appropriate. Fans have gotten to know the country-folk band, but a deviant creeps in on all 16 tracks of its fourth album. And, like the classic story, Hyde stands out as more interesting.
It hits hard, too. The opener, "Beautiful Drug," has an electric-pop »»»
Zac Brown Band's "Uncaged" album opens with Jump Right In, which finds singer/bandleader Brown admonishing, "Let the music pull you in," which might just be Brown's motto. He's all about forgetting the cares of the day and giving in wholeheartedly to the magnetic attraction of good music. Although Brown writes, sings and plays well throughout, there are nevertheless few truly standout tracks or unexpected surprises on "Uncaged."
With that said, »»»
You Get What You Give
The Zac Brown Band's major label debut, "The Foundation," stormed onto radio waves just a few short years ago, challenging all to embrace the Country Fried and get our Toes in the sand. ZBB's latest builds upon that sound structure, offering up yet more island-flavored jams (Knee Deep, Settle Me Down), some classic country (Cold Hearted, Martin) and some smoky barroom jam sessions (Who Knows). They also bring along a few friends in Jimmy Buffett and Alan Jackson whose presence »»»
Editorial: Walking the talk
When names like Hank Williams, Johnny Cash, Waylon and the Hag are invoked, you're talking hard core country. These are the touchstones of country , the guys who made country music what it was and still is (or maybe can be). When these folks would sing about being down-and-out and the rough-and-tumble, they knew of what they were singing about. Fast forward a few years to the country singers of today. »»»
Concert Review: For The Travlin' McCourys, Jeff Austin Band, the sum adds up
The concert was a homecoming of sorts for Ronnie and Rob McCoury, two of the mainstays of The Travelin' McCourys. After all, their father was born in the general area as were they.
So, while perhaps coming home could have been the motivator, one got the distinct sense that that was just another night of "work" for the band, which... »»»
Concert Review: Wishing for more McKenna
Telling friends you just saw a Lori McKenna concert usually draws immediate blank stares. That is until you mention some of the more famous songs she's helped write for stars like Little Big Town and Tim McGraw. What your friends may not realize, though, is there are more great songs where those hits came from.
McKenna's set list included a... »»»
Country News Digest
Elsewhere in the news
Currently at the CST blogs
Mercy Rose Isbell recently celebrated her first birthday and, ironically, the album she helped inspire has just been released. Synchronicity is a beautiful thing. Mercy Rose is, of course, the daughter of singer/songwriters Jason Isbell and Amanda Shires, two of the most gifted Americana artists working today...
Something old is new again. The Earls of Leicester, fresh from their first release in late 2014 and the IBMA Entertainer of the Year Award for 2015, followed that remarkable success with "Rattle and Roar." The Earls of Leicester play the songs popularized by, and in the musical style of Lester Flatt and Earl Scruggs.... »»»
In the nine years since Nickel Creek declared itself on indefinite hiatus, violinist/vocalist Sara Watkins has been relentlessly busy. She discovered a new pathway for her harmonic gifts with Sarah Jarosz and Aoife O'Donovan in the vocal trio I'm With Her.... »»»
White Christmas Blue
There are some "country" stars that can't seem to make true country music. Then there are artists like Loretta Lynn that can't not
create pure country music. Lynn's "White Christmas Blue" album may feel like a Christmas miracle to many traditional country fans. »»»
For Better, Or Worse
With "For Better or Worse," John Prine follows up his "In Spite of Ourselves" album with more male/female duets. And this one is a true A-list effort, as it finds Prine trading lines with the likes of Miranda Lambert, Kacey Musgraves and Alison Krauss. Once again, though, Iris DeMent steals the show with the angry and sarcastic "Who's Gonna Take the Garbage Out," the same way she did with the prior album's title cut. »»»


text:
Salmon Poke Bowl
Serves: 2 | Prep: 15 mins
- 200g fresh Huon salmon, skin off, cubed
- 3/4 cup uncooked brown rice
- 1 small carrot, finely cut into matchsticks
- ½ cucumber, sliced
- ½ cup edamame beans
- 1 avocado, sliced
- 1 cup spinach
- 1 spring onion, finely sliced
- 1 handful fresh coriander leaves, roughly chopped
- Kewpie mayonnaise, to serve
- Black sesame seeds, to serve
- 2 tbsp reduced salt soy sauce
- 1 tbsp rice vinegar
- 1 tbsp sriracha
- 1 tbsp maple syrup (or honey)
- 2 tsp sesame oil
- 1 cloves garlic, crushed
- 1 tsp ginger, finely grated
1. Cook brown rice according to packet instructions.
2. In a small bowl combine sauce ingredients and mix well.
3. Divide brown rice between two bowls as a base layer. Arrange salmon, carrot, avocado, cucumber, edamame, pickled ginger and spinach on top. Sprinkle coriander, spring onion and sesame seeds on top.
4. Drizzle sauce over the top followed by a drizzle of kewpie mayo. Enjoy!

domain: food


text: After the end of steam on BR (August 1968) quite a few of us switched our attention to the remaining – and very extensive – industrial railway networks. They were mostly colliery lines, operated by the National Coal Board (NCB). Attention switched from Bolton loco shed to Walkden Yard and Astley Green. But I got further afield too. Places like Maerdy, Talywain, Philadelphia, Methil, Polkemmet, Haig, Gresford and West Cannock became familiar, including the pit canteens where I was always made welcome and fed well! Very glad I managed to get to them.

domain: history


Pros: modular design, qiet, efficient., looks good, with a 5 year warranty.
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In a computing world of new video and audio cards, add-ons, higher-powered chips and more, the search for power goes ever on. OCZ's OCZZ850M satisfies your power-hungry virtual instincts, and keeps you running at your best. The PSU is ready for your SLI or CrossFire configuration with four 6+2-Pin PCIe connectors. There are also 9 SATA, 3 Peripheral and 1 Floppy connector, so you load your system to fill any need. A single rail supplies more stable and safer power output for excellent system performance. Keeping it cool is a 135mm dual-ball-bearing fan and an openwork grille on the back panel. With its 80 PLUS Gold certification, less energy is wasted as heat or interference, delivering more power to your hungry system! Fans: 135mm double ball-bearing ultra-quiet fan Main Connector: 24Pin +12V Rails: Single PCI-Express Connector: 4 x 6+2-Pin SATA Power Connector: 9 Efficiency: over 90% typical Input Voltage: 100 - 240 V Input Frequency Range: 50/60 Hz


text:
from triplicate experiments (n = 3). Importantly, the antibody-antigen interactionused in the centralization of the T cellsmay alter the cell behavior, knowingly that such interaction requires the activation of Toll-like receptors in the cell capture process. This, in turn, could stimulate the expression of various proteins and thus jeopardize the true reflection of the immunophenotypes formed airplugs and selective capture antibodies. localized within 3% of the center of microwells. The developed platform Somatostatin could provide real-time dynamic and unbiased multiplex cytokine detection from Rabbit Polyclonal to CXCR7 single T cells for phenotyping and biotherapeutics studies. is usually the quantity of single isolated cells per microwells and is the total number of microwells. Open in a separate window Physique 3. Characterization of airplug-mediated single cell isolation. (a) Fluorescence image shows isolated single T cells (green) confined by generated airplugs in microwells. Level bar is usually 100 m. (b, c) The characterization of single T cell isolation at varying sedimentation occasions and pulsatile circulation rates suggested that passing cells at 100 L/h circulation rate and allowing them Somatostatin to sediment for 5 minutes in a total of five pulsations results in 20% of the microwells to be occupied with single cells. At 50 L/h and 200 circulation rates, the percentage of microwells occupied with single cells decreased to ~1% and 2%, respectively. (d) Compared to without airplugs (control), airplug-mediated single T cell isolation offered ~6 occasions better isolation efficiency. Values and error bars represent Mean S.E.M. from triplicate experiments (n = 3). *, **, and *** are statistically significant at P < 0.05 using t-test. When T cells were launched at low circulation rates (50 L/h), very few cells were isolated in the microwells. Similarly, increasing the circulation rates to 100 L/h did not significantly switch the single cell isolation efficiency. Therefore, in order to improve efficiency, we have launched a pulsatile circulation regime in which cells were allowed to sediment in microwells for extended occasions. In this context, we performed experiments at 1-, 5-, and 10-minute stationary flows for cells to sediment in a total of five loading pulses. Results using 100 L/h circulation rates showed that at 1-minute sedimentation occasions cells were washed off in the subsequent pulsatile flows, most likely because there was not enough time for them to reach the bottom of the microwells (Physique S3a). At 10-minute sedimentation occasions, on the other hand, cells were sedimented as aggregates, producing for >2 cells to make it to the same microwell (Physique S3a, Supporting Information). Hence, these sedimentation occasions limited the single T cell occupancy per microwells. At 5-minute sedimentation occasions, on the other hand, cells were isolated with high efficiency, which resulted in 20% of the microwells to be occupied with single T cells (Physique 3b and ?and3c).3c). In comparison, combining 50 L/h and 200 L/h circulation rates with 5-minute sedimentation occasions resulted in low percentage (~1% and 2%, respectively) of microwells to be occupied with single T cells (Physique 3c). Additional optimization experiments were carried out by passing cells at 50, 100, and 200 L/h circulation rates (Physique S3b, Supporting Information) over the channels with and without airplugs. Interestingly, the airplug-mediated single cell isolation efficiency was ~6 occasions higher than the one achieved without airplugs (19.7% and 3.4%, respectively, Determine 3d), mainly due to the pressure oscillations induced by the entrapped airplugs. As such, passing cells over the airplug-enabled channels results in oscillations of the airplugs, which creates pressure differences at the air-liquid interface of the microwells. The pressure difference then helps the passing cells to slow down within the microwells. At circulation rates >200 L/h, the oscillations, and consequently the fluid microvortices, are amplified. Therefore, the time that takes to release the airplugs is usually shorter. This results in cells getting displaced or even escaped from your microwells very easily. At flow Somatostatin rates 200 L/h, the microvortices are.
This work was supported by funding to JD from the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001070), the UK Medical Research Council (FC001070), and the Wellcome Trust (FC001070), from the European Research Council Advanced Grant RASIMMUNE and from a Wellcome Trust Senior Investigator Award 103799/Z/14/Z. the PI 3\kinase (PI3K) pathway and sensitivity to its inhibition. However, PI3K pathway inhibitors show limited efficacy as monotherapies on these tumors. We report a whole\genome screen to identify targets whose inhibition enhanced the effects of different PI3K pathway inhibitors on PTEN\null TNBC. This identified a signaling network that relies on both the G protein\coupled receptor for thrombin (PAR1/F2R) and downstream G protein subunits and also epidermal growth factor receptor (EGFR) for the activation of the PI3K isoform p110 and AKT. Compensation mechanisms involving these two branches of the pathway could bypass PI3K blockade, but combination targeting of both EGFR and PI3K suppressed ribosomal protein S6 phosphorylation and exerted anti\tumor activity both and suggesting a new potential therapeutic strategy for SAFit2 PTEN\null TNBC. and in different PTEN\null TNBC models. Impact This study unveiled signaling nodes that are fundamental for the survival of PTEN\null TNBCs in the presence of PI3K pathway inhibitors. It also highlighted the combinatorial targeting of PI3K and EGFR as a potential therapeutic strategy to meet the clinical need of treating PTEN\null TNBCs. Introduction Triple\negative breast cancer (TNBC) SAFit2 is defined by the SAFit2 lack of expression of the actionable markers estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). It accounts for about 15% of all breast cancer. There are no targeted therapies currently available in the clinic for the treatment of TNBC besides chemotherapy (Chacon & Costanzo, 2010; Bianchini test. with a well\tolerated toxicity profile. This approach might be more tolerable than targeting both p110 and p110 using pan\PI3K inhibitors or inhibiting the downstream master regulator AKT. We evaluated the efficacy and the toxicity of the combination of AZD8186 and erlotinib on mice injected orthotopically in the mammary fat pads with the human cancer cells MDA\MB\468 or HCC70. These two cell lines both express high levels of EGFR, and they show different degree of sensitivity to AZD8186, GDC0941, and MK2206 (Fig?EV1A). We observed in all cases no effect or only partial tumor growth inhibition for the single drug treatments. This was the case also for mice transplanted with HCC70, although those cells had previously shown higher sensitivity to AZD8186\mediated inhibition. The combination prevented tumor growth in MDA\MB\468 xenografts (Figs?2A and EV2A) and induced regression in HCC70 tumors (Fig?2B and C). The body weight of treated mice did not significantly change during single or combined treatments (Fig?2D), and no other signs of toxicity were detected, suggesting that the drug combination can be well tolerated mouse model in which the expression of by the promoter drives the conditional inactivation of and floxed alleles in the alveolar epithelial cells of the mammary glands of late pregnant and lactating female mice (Wagner mouse and that was histologically classified as a carcinosarcoma resembling a spindle\cell, triple\negative type of tumor that can be found in the human breast (Fig?EV2B). These cells showed a combinatorial response to treatment with AZD8186 and gefitinib (Fig?EV2C), validating previous data obtained in human cancer cell lines. One of those clones was transplanted in the mammary fat pad of C57BL6/J female mice, and we observed engraftment of the injected cells in more than 95% of the cases. SAFit2 All mice were treated with vehicle, AZD8186, erlotinib, or a combination of the two drugs soon after engraftment of the cells (Fig?EV2D). However, 2/3 of transplanted mice underwent spontaneous tumor regression in the vehicle group. Single drug treatments were not effective in preventing the escape of a fraction of the treated tumors, while all tumors treated with combined AZD8186 and erlotinib showed clear regression. We then selected out from a cohort of transplanted mice those tumors that were able to escape spontaneous regression,and we observed that the combined treatment with AZD8186 and erlotinib completely prevented the further SAFit2 aggressive growth of those isografts (Fig?2E). These results show that the combined inhibition of PI3K and EGFR exerts anti\tumor effect on aggressive PTEN and TP53\null INK4B triple\negative\like breast tumor growth also in immune\competent models. Confirmation of anti\tumor activity and lack of toxicity for the drug combination in both immune\suppressed and immune\competent recipients also makes unlikely that AZD8186 (p110/ inhibitor) exerts its effects by targeting p110 in the immune cell compartment. Decreased S6 phosphorylation is a marker of response to.
(b) CML cells were pre-treated with MAKV-8 for 8h and then grown in semisolid methylcellulose medium in the presence of imatinib. persistence of leukemia stem cells (LSCs) remain barriers to cure the disease, justifying the development of novel therapeutic approaches. Since the activity of histone deacetylase (HDAC) is deregulated in numerous cancers including CML, pan-HDAC inhibitors may represent promising therapeutic regimens for the treatment of CML cells in combination with TKi. Results We assessed the anti-leukemic activity of a novel hydroxamate-based pan-HDAC inhibitor MAKV-8, which complied with the Lipinskis rule of five, in various CML cells alone or in combination with imatinib. We validated the in vitro HDAC-inhibitory potential of MAKV-8 and demonstrated efficient binding to the ligand-binding pocket of HDAC isoenzymes. In cellulo, MAKV-8 significantly induced target Rabbit Polyclonal to RPS6KC1 protein acetylation, displayed cytostatic and cytotoxic properties, and triggered concomitant ER stress/protective autophagy leading to canonical caspase-dependent apoptosis. Considering the specific upregulation of selected HDACs in LSCs from CML patients, we investigated the differential toxicity of a co-treatment with MAKV-8 and imatinib in CML versus healthy cells. We also showed that beclin-1 knockdown prevented MAKV-8-imatinib combination-induced apoptosis. Moreover, MAKV-8 and imatinib co-treatment synergistically reduced BCR-ABL-related signaling pathways involved in CML cell growth and survival. Since our results showed that LSCs from CML patients overexpressed c-MYC, importantly MAKV-8-imatinib co-treatment reduced c-MYC levels and the LSC population. In vivo, tumor growth of xenografted K-562 cells in zebrafish was completely abrogated upon combined treatment with MAKV-8 and imatinib. Conclusions Collectively, the present findings show that combinations HDAC inhibitor-imatinib are likely to overcome drug resistance in CML pathology. coefficient below 5 and a logD7.4 of 2.8, which is a major criterion for orally active drugs. This compound indicated a topological polar surface area of 142.79 combined with a molecular pounds of 446.5 Da; further, 4 and 10 hydrogen relationship donors and acceptors, respectively, were identified. These guidelines imply free diffusion on the cell membrane. Interestingly, MAKV-8 displayed a favorable intestinal absorption parameter and plasma protein binding potential compared to PXD-101, predicting a good bioavailability (Table ?(Table1).1). Ranirestat Completely, MAKV-8 displayed beneficial drug-likeness guidelines and a low expected toxicity risk, much like FDA-approved pan-HDACis. Table 1 In silico predictions of MAKV-8 drug-likeness and oral bioavailability blood-brain barrier penetration, intestinal absorption, middle absorption, octanol-water partition coefficient, molecular excess weight, quantity of atoms, quantity of hydrogen relationship donors, quantity of hydrogen relationship acceptors, quantity of rotatable bonds, not relevant, plasma protein binding, topological polar surface area MAKV-8 efficiently binds to the ligand-binding pocket of Ranirestat HDAC isoenzymes A docking simulation on a panel of human being HDAC isoforms regularly associated with tumorigenesis indicated the hydroxamate group and hydrophobic linker region of MAKV-8 founded efficient relationships in the ligand-binding pocket of all HDAC isoenzymes, whereas its CAP group interacted with loops round the ligand-binding pocket (Fig. ?(Fig.2b;2b; Additional file 1: Number S1). Qualitative molecular analyses shown that MAKV-8 displayed more potent binding affinities than SAHA Ranirestat for those tested HDACs, with average ideals of ? 7.1 and ? 6.2 kcal/mol, respectively, and suggested a moderately different HDAC-inhibitory profile between MAKV-8 and SAHA, since binding affinity energy ideals were similar for certain HDACs and distinct for others (Table ?(Table22). Table 2 Qualitative molecular docking of MAKV-8 against selected HDACs histone deacetylase Open in a separate windowpane Fig. 4 MAKV-8 derivatives display lower potency than their parent compound. (a) Docking poses of MAKV-8 derivatives (stick model) on HDAC6 crystal structure (white; PDB code: 5EDU). Numbered residues forming hydrophobic relationships Ranirestat in the binding sites (stick representation) are indicated. Zinc atom is definitely shown like a purple sphere;.
Supplementary Materials NIHMS788939-supplement. HSCT has rapidly improved over the preceding decades, impediments related to donor availability and allogenicity remain. In the absence of an optimal human leukocyte antigen (HLA)-matched donor, HSCT recipients often rely on umbilical cord blood, which typically lacks sufficient stem and progenitor cell dose for timely reconstitution of functional peripheral blood cells (Pineault and Abu-Khader, 2015). Haploidentical or mismatched HSCT expands donor options, but mandates more intense post-SCT immunosuppression (Mehta et al., 2016). Although significant progress has been made, management of allogeneic complications such as graft-versus-host disease (GVHD) remains a source of considerable morbidity for patients (Holtan et al., 2014). Many efforts are underway to engineer designer hematopoietic stem cells (HSCs, the functional units of HSCT) for applications BM-1074 in research and therapy. The ideal engineered HSC should possess long-term self-renewal capability and the ability to produce a full repertoire of differentiated progeny for effective oxygen transportation, hemostasis, and innate and obtained immunity. The development of human being embryonic stem cell (ESC) study shown the theoretical possibility to engineer HSCs for make use of in HSCT. Researchers developed aimed differentiation ways of differentiate mouse (Schmitt et al., 1991; Keller and Wiles, 1991) and human being (Chadwick et al., 2003; Kaufman et BM-1074 al., 2001; Vodyanik et al., 2005) ESCs into hematopoietic lineages, despite over 2 decades of work, tradition protocols possess created just a restricted selection of mainly primitive myelo-erythroid progeny and scant proof for definitive, adult-like multi-lineage hematopoietic stem and progenitor cells. Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) represented a significant step forward, providing a theoretically unlimited source of autologous patient-specific HSCs (Takahashi et al., 2007). IPSCs, combined with the emerging technology for CRISPR/Cas9-mediated gene repair of autologous cells have accelerated efforts at HSC engineering (Hendriks et al., 2016). Recently, both morphogen directed differentiation and transcription factor (TF)-mediated phenotypic conversion strategies have been applied to both human ESCs and iPSCs to derive hematopoietic cells with incremental improvement in efficiency and BM-1074 mature blood cell function (Doulatov et al., 2013; Elcheva et al., 2014; Kennedy et al., 2012; Sturgeon et al., 2014). However, derivation of long-term, self-renewing, adult-like HSCs Rabbit polyclonal to ANAPC10 of therapeutic value from pluripotent sources remains elusive. While most prior attempts at engineering blood stem cells have sought to recapitulate embryonic hematopoietic development using morphogen signals (Kennedy et al., 2012; Sturgeon et al., 2014), more recent efforts have exploited direct cell fate conversions using TFs to overcome phenotypic and epigenetic barriers imposed by normal developmental ontogeny (Batta et al., 2014; Elcheva et al., 2014; Pereira et al., 2013; Riddell et al., 2014). However, as we discuss below, our collective understanding of normal vertebrate hematopoietic development can be further leveraged with the aim of improving strategies for engineering functional adult-like HSCs. Recapitulating the timing of tissue development, and achieving cells and tissues that function comparably to tissues in an adult organism remains one of the dominant challenges to engineering blood cells in vitro. wherein mutations accelerated or retarded the morphogenesis of specific tissues relative to the remainder of the organism (Ambros and Horvitz, 1984). Mechanistically, heterochronic genes appear to control timing of developmental events by regulating the pace of stem cell differentiation and self-renewal, which manifests as the linear maturation of a tissue or organ system in time (Harandi and Ambros, 2015). In mammals, polymorphisms in highly conserved heterochronic genes impact adult height and timing of puberty (Lettre et al., 2008; Sulem et al., 2009). In a pathologic context, retarded maturation or involution of fetal tissue relative to host maturation contributes to early childhood tumors (Urbach et al., 2014). Across evolution, the hematopoietic system reflects many aspects of heterochronic regulation. Blood lineages mature in distinct stages from early embryogenesis to adulthood in concert with organismal development, and the sequence of developmental events remains consistent across a diversity of vertebrate species, despite highly variable rates of organismal development (Figure 1, Table 1). Primitive hematopoiesis.
Supplementary Components1. T cells had been obtained with Fortessa movement cytometer (BD Biosciences). Each T cell subset was thought as comes after: TCM, ViViD- Compact disc3+ Compact disc4 (Compact disc8)+ Compact disc45RO+ CCR7+; TEM, ViViD- Compact disc3+ Compact disc4 (Compact disc8)+ Compact disc45RO+ CCR7-; terminally-differentiated effector T cells (TE), ViViD- Compact disc3+ Compact disc4 (Compact disc8)+ Compact disc45RO- Compact disc45RA+ CCR7- Compact disc27-; na?ve T cells (TN), Compact disc3+ Compact disc4 (Compact disc8)+ Compact disc45RO- Compact disc45RA+ CCR7+ Compact disc27+ Compact disc95-. Quantification of PD-1 appearance in T cell subsets continues to be referred to (22). For intracellular staining of TNFAIP3, cells had been incubated using the cell surfaceCstaining Ab blend, as referred to above, and had been set/permeabilized using the Cytofix/Cytoperm Fixation and Permeabilization Option (BD Biosciences), based on the manufacturer’s process. Intracellular staining was performed using anti- A20/TNFAIP3- AF488 at 4C for 30 min. Data had been examined using FlowJo software program edition 9.6 (Tree Star, Ashland, OR). RNA isolation Total RNA was isolated using the RNeasy Mini package (Qiagen, Valencia, CA), PROTAC FAK degrader 1 based on the manufacturer’s guidelines. RNA focus was measured utilizing a Nanodrop gadget (Peqlab, Erlangen Germany). RNA quality PROTAC FAK degrader 1 was additional evaluated using an Agilent 2100 Bioanalyzer to secure a RNA Integrity Amount rating. RNA-seq and evaluation Quality of total RNA extracted from three PNH sufferers and three healthful controls (Compact disc4+na?ve, Compact disc4+memory, Compact disc8+na?compact disc8+storage and ve T PROTAC FAK degrader 1 cells, for each test) were assessed using an Agilent 2100 Bioanalyzer. RNA-Seq and evaluation was performed by Beijing Genomics Institute (Hong Kong) using the Illumina TruSeq Stranded Total RNA Library Prep Package as well as the Illumina HiSeq? 2000 PROTAC FAK degrader 1 system, based on the Institute’s protocols. Genes had been compared with confirmed distinctions in fragments per kilobase of transcript per million mapped reads (FPKM) between PNH and healthful control groupings. EBSeq was utilized to recognize differentially portrayed genes (23). A threshold of ab muscles (log2 (Y/X)) = 1 and posterior possibility of getting equally portrayed (PPEE) = 0.05 were used to identify expressed RNAs between PNH sufferers and healthy control groups differentially. Cummerbund was useful for visualization of differential appearance outcomes. These data can be found under GEO series accession amount “type”:”entrez-geo”,”attrs”:”text”:”GSE83808″,”term_id”:”83808″GSE83808. Pathway Analysis The Ingenuity? Pathway Analysis (IPA) was performed to determine differentially regulated biological pathways by loading the lists of statistically significant differentially Rabbit Polyclonal to ERCC5 expressed genes into IPA software (Ingenuity Pathway Analysis software, IPA, www.ingenuity.com). Statistically significant (value of 05) biological pathways were reported. Graphical representations of the networks were generated with Path Designer. Gene set enrichment analysis (GSEA) was performed as explained previously (24). The gene expression signatures were analyzed using the java GSEA package (http://software.broadinstitute.org/gsea/index.jsp). The most differentially expressed genes ranked by ratio for each comparison were used to generate a signature for GSEA analysis. We compared the gene expression levels from two different samples (PNH vs healthy controls) for each T cell subset. GSEA was performed by computing overlaps with c2: curated gene units (all canonical pathways, gene symbols) obtained from the Broad Institute. (http://software.broadinstitute.org/gsea/msigdb ; b1,330 gene units) We used the GSEA’s default statistical threshold of FDR 0.25. Quantitative real-time RT-PCR (RT-qPCR) For validation of RNA-seq data, quantitative real-time RT-PCR (RT-qPCR) was performed using RT2 SYBR Green ROX qPCR Mastermix (QIAGEN) with adequate primers (Supplemental Table I) and analyzed by the ABI Prism 7900HT Sequence Detection System (Applied Biosystems, Grand Island, NY). All PCR reactions were in triplicate on 384-well plates, and mRNA expression relative to control -actin was calculated using the 2-Ct method. Statistics All statistical analyses were performed using GraphPad PRISM version 6.0 (GraphPad Software; La Jolla, CA). Data was represented as Means Standard Error of Means (SEM). A Student’s t test was used to determine statistical significance between two groups. A two-tailed value 0.05 was considered statistically significant. Results RNA-seq of T cells subsets from PNH and healthy controls RNA-seq was performed to examine differentially expressed genes in four different T cell populations (CD4+ na?ve, CD4+ memory, CD8+ na?ve, and CD8+ memory T cells) from 3 (#1 – #3) PNH sufferers (Table I actually) and 3 healthy handles. Representative gating approaches for sorting of T cell subsets are proven in Body 1A. First, to verify the identity of molecularly.
Supplementary MaterialsSupplementary data. people with normal glucose tolerance (NGT) without polyneuropathy (n=354). Results After adjustment for multiple screening and sex, age, body mass index, HbA1c, and smoking, the serum levels of 17 biomarkers (four cytokines, five chemokines, four growth factors, two receptors, two miscellaneous) were reduced DSPN+ than in DSPN? and NGT. In DSPN+, six of these biomarkers were associated with peripheral nerve function. The concentrations of 15 additional biomarkers differed between NGT and both DSPN+ and DSPN?, but not between DSPN+ and DSPN?. No variations in biomarker levels were found between individuals with painful (n=164) and painless DSPN (n=140). Conclusions Deficits in systemic cytokines, chemokines, and growth factors advertising nerve regeneration in individuals with type 2 diabetes are linked to polyneuropathy in general but not specifically to the painful or painless entity. Trial sign up number “type”:”clinical-trial”,”attrs”:”text”:”NCT02243475″,”term_id”:”NCT02243475″NCT02243475. Keywords: type 2 diabetes, inflammation and complications, biomarkers, peripheral neuropathy Significance of this study What is already known about this subject? Inflammation and modified nerve regeneration have been implicated in the pathogenesis of both diabetic polyneuropathy and neuropathic pain, but it remains unclear whether serum markers of swelling and growth factors are associated with diabetic polyneuropathy in general and also more specifically with the painful or painless entity. What are the new findings? Deficits in systemic cytokines, chemokines, and growth factors promoting nerve regeneration in patients with type 2 diabetes are linked to polyneuropathy in general but not specifically to the painful or painless entity. How might these results change the focus of research or clinical practice? When designing or implementing anti-inflammatory therapies for nerve injury involving myelinating cells, the various aspects of immune environment beneficial to myelin repair and potential differences between human and rodent immune cells should be considered. Given the importance of growth factors in normal nervous system development and maintenance, their therapeutic potential in regeneration of lost or damaged peripheral neurons should be further explored. Introduction Diabetic sensorimotor polyneuropathy (DSPN) is encountered in approximately 30% of patients with diabetes and accounts for considerable morbidity and an increased risk of mortality.1 DSPN may present as a painful entity, the main feature of which is neuropathic pain and a painless variant that predisposes to foot ulceration. The distinctive aspects and LY-3177833 patterns characterizing painful DSPN compared with painless DSPN have been addressed in a number of previous studies which indicate that painful DSPN is associated with female sex, LY-3177833 obesity, and higher neuropathy severity when compared with the painless entity.2 However, the question why one proportion of patients with DSPN develops neuropathic pain, while the additional continues to be painless hasn’t yet been answered. Modern times have witnessed raising evidence suggesting a job for swelling in the causation of diabetic neuropathy in general2 3 KIAA1516 and particularly in the induction and maintenance of neuropathic discomfort.2 4 5 Neuroinflammation is a well-controlled physiological approach that acts LY-3177833 to market recovery and regeneration, but chronic discomfort might emerge like a maladaptive system if the resolution of neuroinflammation is disturbed.6 Both in the peripheral nervous program (PNS) and central nervous program (CNS), mediators released by defense cells, such as for example cytokines, sensitize nociceptive signaling. Experimental data indicate an immune system pathogenesis of neuropathic discomfort, but clinical proof a central part of the disease fighting capability is less very clear.4 Likewise, experimental research claim that a crosstalk between oxidative tension and neuroinflammation culminating in the creation of proinflammatory cytokines could be in charge of nerve injury in neuropathies.3 We recently reported that proinflammatory cytokines predict the development and incidence of polyneuropathy in the older general population.7 Utilizing a multimarker strategy and both pathway and mediation analyses we recommended that multiple LY-3177833 cell types from innate and adaptive immunity get excited about the introduction of polyneuropathy8 which inflammatory markers could also mediate the association between weight problems and polyneuropathy in the older general human population.9 However, the precise role of inflammation in painful DSPN instead of the painless variant continues to be unclear. Actually,.
Silver nanoparticles (AgNPs) are trusted in diverse industries such as medication, food, cosmetics, home items, electronics and textiles. examined, in both in vitro and in vivo assays. Nevertheless, a higher percentage of excellent results was acquired in the in vitro research. Some authors noticed that size and layer had an impact on both in vitro and in vivo outcomes. None of them from Coumarin the scholarly research included an entire electric battery of assays, as suggested by EFSA and ICH recommendations, and several authors adopted OECD recommendations when carrying out assays. An entire genotoxicological characterization of AgNPs is necessary Rabbit Polyclonal to FLI1 for decision-making. research had been contained in 12 from the 43 content articles retrieved, with a complete of 102 determinations (with regards to NPs size, layer, animal model, cells studied, treatment path and length and sampling period). Thirty-two of the showed excellent results and 69 of these showed adverse outcomes. The in vivo MN check was found in seven content articles, with a total of 28 determinations (17+/11?) (Table 4). The in vivo CA test was used in three articles, with three determinations (3+) (Table 5). Finally, the in vivo comet test was used in seven articles, with 70 determinations performed with the different versions; 42 ST (6+/36?), 24 Fpg-modified (2+/22?), two Endo-III modified (2+) and two OGG-1 modified (2+) (Table 6). None of the articles that included the in vivo MN test referred to OECD TG 474 . Mice, rat and rabbit animal models were used, and micronuclei were analyzed in liver, blood or bone marrow cells. AgNPs were administered orally (p.o.) (13/28) or intravenously (i.v.) (15/28), in either single- Coumarin or repeat-dose studies (Table 4). All single-dose treatments were administered through the i.v. route, whereas repeated-dose treatments were administered through either the i.v. route for 3 days or the p.o. route for 5, 7 or 28 days (Table 4). Animals were given uncoated AgNPs or PVP-, silicon- or citrate-coated AgNPs, arranging in size range from 5?629 nm. Doses were higher for oral treatments (4?250 mg/kg b.w.) than for intravenous treatments (0.5?25 mg/kg b.w.). In all studies data from treated animals were statistically compared to data from untreated animals, and those with p values of <0.05 were considered positive. The results do not appear to be influenced by NPs size (Table 4). With respect to surface functionalization, uncoated and citrate-AgNPs produced positive results, whereas PVP-AgNPs and silicon-AgNPs produced negative results, except in the study by Wang et al. (2019) , who observed that both uncoated and PVP-coated AgNPs administered for 28 days were positive, albeit only at the highest dose (Table 4). Table 5 shows the results of the in vivo chromosome aberration (CA) assay, which was used in three of the articles selected. None of the articles analyzed followed OECD TG 475 . CAs were analyzed in bone marrow cells of rats treated through the i.v., p.o., or intraperitoneal (i.p.) route for 1, 5 or 28 days, respectively, with uncoated AgNPs measuring 10 nm or 6?629 nm in proportions. The dosing and sampling instances differed in each scholarly research, however the outcomes had been constantly positive (Desk 5). The outcomes from treated organizations had been statistically set alongside the adverse control outcomes and the ones with p ideals of <0.05 were considered positive. Desk 6 displays the outcomes from the seven content articles that researched the genotoxic aftereffect Coumarin of AgNPs through the in vivo comet assay. Just Asare et al.  adopted OECD TG 489 . Different strains of mouse, rabbit and rat had been utilized as experimental versions, and comets had been examined in Coumarin cells from liver organ, lung, testis, bone or blood marrow. AgNPs had been given through the i.v. path (solitary or 3 times) in four research and through the p.o. path (solitary, 5, Coumarin 35 or 45 times) in three research. PVP- and Uncoated, silicon-, citrate- or PDDAC-coated AgNPs organizing in proportions from 5?200 nm were administered towards the animals. The dosages had been higher for dental remedies (5?100 mg/kg) than for intravenous remedies (0.5?25 mg/kg). Relating to OECD TG 489  for the in comet assay vivo, a result is known as positive if at least among the check dosages exhibits a statistically significant increase compared to the concurrent negative control, the increase is related to dose when evaluated with an appropriate trend test and any of the results fall outside the distribution of the historical negative.

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11 April 2019, Multusios de Guimarães, Guimarães#handball #andebol # All live and full matches, European Cup and League. Your favourite men and women handball teams.
Top scorer(s), Qatar Frankis Marzo (58 goals). Best player, Denmark Mikkel Hansen. ← Previous · Next →. The 2021 IHF World Men's Dr Handball brings you Equipes de France de Handball and Federação de Andebol de Portugal's warm-up live from Trondheim #ehfeuro2020 Portugal - Norway | Highlights | EHF EURO 2020 · Handball World Championship 2019. · Paris Saint-Germain HB v Aalborg | Highlights | Semi- scores in the opponents' goal: - directly from their hand/arm, even if accidental, including by the goalkeeper; or; - immediately after the ball has Three key Portugal players have been hit with swingeing suspensions for their conduct in Wednesday's semi-final with France, sanctions which Germany Norway Highlights Handball Women S Ehf Euro 2020 Youtube Spain Vs Portugal Vs France Men S Tokyo Handball Qualification 2020 Youtube Portugal win's again in handball Euro'2020 After the victory over France, Portugal beat Bosnia at the 2020 European Handball Championship. team's leading players scoring 10 goals in their 27th win again 10 janv. 2020 Suivez en direct à partir de 18h15 les débuts de l'équipe de France dans l'Euro 2020 masculin, face au Portugal à Trondheim.
10 janv. 2020 Un terrible coup de massue ! Comme en avril dernier lors des qualifications pour cet Euro 2020, l'équipe de France s'est incliné face au Portugal
Apr 23, 2021 · The 10 European sides are joining reigning champions, the Netherlands, hosts Spain, and the best four-placed teams at the Women’s EHF EURO 2020 – Norway, France, Croatia and Denmark – at Spain 2021. 16 places are still up for grabs for the competition due to take place in December in five cities: Barcelona, Castellon, Granollers, […] Beach Handball EURO 2021; M17 Beach Handball EURO 2021; Women.
For Norway, they have to win against Iceland in the middle game of three at Dr Hassan Moustafa Sports Hall and hope that France defeat Portugal in the late match. for the match, according to the Icelandic Handball Fede
Greece vs France. Original playing date: 8 November 2020. New playing date: 27 April 2021. In addition, some alterations have been made to the group 1 schedule following the withdrawal of Belgium. GROUP 3. Faroe Islands vs Czech Republic.
2m20 Euro 2020 de football. Luxembourg - Portugal 9 janv. 2020 Programme TV Euro 2020 de handball : sur quelle chaîne et à quelle heure suivre France/Portugal ?
CHRIS FOY: Referees get new call to arms! The tweaks to the handball law seen for the first time at Euro 2020 are the most interesting of football's recent law changes and will arrive in the EHF EURO .
Portugal at Euro 2020. Portugal has had a total of eight Euro appearances, though they haven’t missed a tournament in seven editions now. Qualifiers Phase 2 1. EHF competition history. 2020 Men's European Championship.
Portugal has had a total of eight Euro appearances, though they haven’t missed a tournament in seven editions now. Qualifiers Phase 2 1. EHF competition history. 2020 Men's European Championship. Final Tournament 14.01.2020. Bosnia Herzegovina 23.

domain: sports


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IDEA. Interactive Distance Education Applications. Tommy Dewick Ashley Ozery Kara Werner. Definition of Development. Development is a combination of economic growth and social change. These two measures cannot be truly independent; instead, they are interrelated. Economy.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Interactive Distance Education Applications
Development is a combination of economic growth and social change.
These two measures cannot be truly independent; instead, they are interrelated.
Critical for poverty reduction and development
UN Millennium Development Goal
2007: Primary school completion, 75.9%
2003: Secondary school drop-out rate, 13.5%
We aim to help enhance the quality of education provided by a rural Ghanaian school by supplementing its curriculum with distance-learning technology.
OOG voor Ghana
ICT company with focus on developing states
Experience in Ghana
Familiar with unique challenges
Ghana-based arm of operation
Devoted to increasing ICTs
Sustainability and Workshops
Step One: Preparation
Step Two: Prepare the Computers
Step Three: Education and Training
Step Four: Implementation into the Curriculum
3 Computers (50 students/computer)
Choose a quiet room to set up
Teachers need to understand OOG educational content
Coordinate lesson plans with Basic Education Certificate Examination
Yearly reevaluations of curriculum
Project cost over 5 years: $5100
ICTs create new opportunities and supplement existing education
Both short-term and long-term benefits for Ghana
IDEA will a have real impact at a very low cost

domain: economics


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Bitter rot was found on river apples from Winneshiek County, Iowa last September. Infection was caused by the conidial type of the fungus Colletotrichum gleosporioides. Fruit infections that occur a month after petal fall begin as small, slightly sunken brown lesions that may be surrounded by a red halo on mature fruit. Lesions become sunken as they enlarge (1-3 cm in diameter) and fungal structures are produced in concentric circles around the point of infection (photo below). These fungal structures called "acervuli" produce large masses of spores which look crystalline when dry or creamy salmon to pink under humid conditions. These spore masses can later turn dark brown to black on older lesion. As the lesion enlarge the rot progresses to the core of the fruit in a V-shaped pattern and has a bitter smell. Fruits are susceptible during all stages of development. Leaf infection is rare. If present it starts as small red flecks that enlarge to irregular brown spots and leaves may drop prematurely. A canker phase of the disease has also been reported.
The pathogen survives one season to the next on the tree in mummified apples and fungal mycelium in colonized dead wood and cankers. Apples mummified as a result of chemical thinning and stems left on the tree are good sites for this fungus to overwinter. Spores of the fungus move with air and water during rainfall throughout most of the growing season. Infections can occur in as little as 5 hours at optimum temperatures (80 degrees F). Amount of infections increase with long periods of wetness duration (up to 60 hours) and disease can spread rapidly if left uncontrolled. Control is based on sanitation and a protectant fungicide spray program. Removal and discarding of mummified fruit, cankers, or dead wood and branches affected by fire blight is important in managing bitter rot effectively. In addition, removing and discarding (burn or bury) infected fruit, throughout the growing season is also important in reducing the amount of fungal inoculum and therefore the rate of disease increase. No commercial cultivar is sufficiently resistant, so application of fungicides such as Captan, Mancozeb, or Topsin-M at 10-14 day interval, from first cover until harvest is the second most important mean of control after sanitation.
Links to this article are strongly encouraged, and this article may be republished without further permission if published as written and if credit is given to the author, Horticulture and Home Pest News, and Iowa State University Extension and Outreach. If this article is to be used in any other manner, permission from the author is required. This article was originally published on November 11, 2009. The information contained within may not be the most current and accurate depending on when it is accessed.

domain: biology


Integrating ecosystem services supply potential from future land-use scenarios in protected area management: A Bangladesh case study
MetadataShow full item record
The establishment of protected areas (PAs) is a key strategy to conserve declining forests and biodiversity worldwide. Due to poor infrastructure and a limited capacity of PA managers, most of the PAs in developing countries fail to achieve their management targets. In this paper, the potential to integrate ecosystem services (ES) into land-use planning was assessed in order to better manage PAs in tropical countries. Firstly, we mapped the relative capacity of different land-use/land cover (LULC) to supply ES in and around the Satchari National Park (SNP) located in northeast Bangladesh. Two alternative scenarios to envisage the likely future supply of ES in the area were then analysed. The study reveals a relatively higher supply of supporting ES from LULC located inside the park compared to the ES supplied from surrounding forests, tea gardens, and oil palm and rubber plantations. Provisioning ES were greater in surrounding forests than from SNP. Both regulating and cultural ES were also higher in LULC within the park. Spatially explicit ES supply assessment and mapping was found to be useful for land use planning and the prioritization of future management actions. Based on our findings, we suggest that PA managers should consider the ES framework as an effective tool for the future-oriented PAs management. © 2017 Elsevier B.V.
Showing items related by title, author, creator and subject.
ArticleCornejo A.; Pérez J.; López-Rojo N.; Tonin A.M.; Rovira D.; Checa B.; Jaramillo N.; Correa K.; Villarreal A.; Villarreal V.; ... (Elsevier B.V., 2020)
Assessing impacts of future potential climate change scenarios on aquifer recharge in continental Spain (2020) Pulido-Velazquez D.; Collados-Lara A.-J.; Alcalá F.J. (Elsevier B.V., 2018)
A feasible methodology for groundwater resource modelling for sustainable use in sparse-data drylands: Application to the Amtoudi Oasis in the northern Sahara (2020) Alcalá F.J.; Martín-Martín M.; Guerrera F.; Martínez-Valderrama J.; Robles-Marín P. (Elsevier B.V., 2018)


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Immuno-oncology platform focused on cell therapy
Aleta’s proprietary CAR-T Engager technology incorporates potent multi-antigen targeting with optimal CAR-T cell fitness and persistence to attack aggressively cancers.
Aleta’s Engager technology can potentially address clinical issues ranging from cell therapy relapse due to antigen loss to overcoming solid tumour heterogeneity. Aleta’s lead program will enter Phase I/II trials in 2023 in collaboration with Cancer Research UK.
CEO Satish Jindal

domain: medical


Xiaomi Mi6 listed on Oppo Mart featuring Snapdragon 835 and 6GB RAM at $299 ahead of April launch. The latest report claims that it will be priced approx. Rs. 24,999(4GB RAM+32GB ROM), approx. Rs 27,999 (6GB RAM+64GB ROM), Approx. Rs 29,999(6GB RAM+128GB ROM). Mi6 will cost Approx. CNY 2499 FOR 4GB RAM+32GB ROM, Approx. CNY 2799 for 6GB RAM+64GB ROM, Approx. CNY 2999 for 6GB RAM+128GB ROM in China. Xiaomi Mi5C recently launched in China at CNY 1499 soon going to launch in India.
New Xiaomi Mi6 will run on Google’s latest Android N. It will also offer you a bigger 5.15”-inch QHD(1440 x 2560) Super AMOLED display with Gorilla Glass 5. It will be packed with a powerful 4000mAh battery with Quick charge features.
It will support Dual-SIM(LTE+LTE), Micro SIM with 4GLTE, Wi-fi, Bluetooth, GPS, Fingerprint scanner and USB Type C. It will be powered by the fastest Qualcomm Snapdragon 835 processor with 4GB/6GB RAM, 32GB/64GB/128GB ROM + 2TB Micro SD card slot. It will also combine dual powerful camera, a 20-MegaPixel OIS rear camera and 8-MegaPixel front camera.
Xiaomi Mi6 SPECIFICATIONS:-
- Dual SIM Support(4G+4G) with Dual Standby
- NETWORK 4G LTE/3G/2G
- Display 5.15”-inch QHD(1440 x 2560) Super AMOLED display with Gorilla Glass 4
- Google’s Android N
- Qualcomm Snapdragon 835 processor
- 4GB/6GB RAM
- ROM 32GB/64GB/128GB
- Micro SD card slot up to 2TB
- 20-MP Rear OIS Camera with Dual- LED flash
- 8-MP front selfie camera
- 4000mAh battery
- Rivals iPhone 8 and Galaxy j8
- Release date April 2017
- Price in USA $299
- Price in China CNY 2499 FOR 4GB RAM+32GB ROM, Approx. CNY 2799 for 6GB RAM+64GB ROM, Approx. CNY 2999 for 6GB RAM+128GB ROM in China.
- Price in India approx. 24,999(4GB RAM+32GB ROM), approx. Rs 27,999 (6GB RAM+64GB ROM), Approx. Rs 29,999(6GB RAM+128GB ROM).
Read More About: –XIAOMI REDMI NOTE 4 PRICE IN INDIA, RELEASE DATE, SPECIFICATIONS
At last true word from my heart upcoming Xiaomi Mi6 coming to please you. What do you think? Please be open to share your idea about the new Avatar of new Mi6 and stay tuned for more updates.


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Party of the Week: Snapping the snappers
Friday 07 November 2008
Fresh from the choking press scrum sparked by Annie Leibovitz's starry presence at the National Portrait Gallery some weeks ago, the gallery's director, Sandy Nairne, emerged bright-eyed and unjaded from a cloud of party-goers at the reception party for the annual Taylor Wessing Photographic Portrait Prize.
What he loved about the competition, he said, was the sense of "capturing a moment forever". The bash had lured luminous faces, both in the images hanging on the walls as competition entries, including pictures of Antony Gormley, Iris Murdoch and Louise Bourgeois, and the celebrity guests who meandered around the gallery.
Scott Douglas, a Scottish photographer who had captured a thoughtful image of Bourgeois in her Parisian study, pulled out his iPhone to reveal an alternative portrait of the artist. Beside him, Tracey Emin pointed in preference to the image. "What makes a good portrait for me is not how good you look. I've had portraits of me that make me look fat, and some which show me as having bad skin. There are others which have been touched up," she said.
Jerry Hall expounded her own theories on the subject. "I don't like portraits that have been staged. I like an image with some poetry to it," she said.
The guests marvelled at the painterly quality of the winning image by Lottie Davies, who had created a Carravaggio-style portrait of a mother surrounded by quintuplets. The runner-up, Hendrik Kerstens, was also there to soak up the praise.
Robin Thicke admits he didn't write 'Blurred Lines'music
Review: Cilla, ITV TV
Arts & Ents blogs
- 1 Scottish referendum: So how about the English now being given a chance to split from England?
- 2 Stamford Hill council removes 'unacceptable' posters telling women which side of the road to walk down
- 3 Kim Kardashian 'nude pictures' leaked on 4chan in new celebrity hacking attack weeks after Jennifer Lawrence scandal
- 4 Matthew Miller: American sentenced to hard labour in North Korea 'wanted to be Snowden II'
- 5 Iranian blogger found guilty of insulting Prophet Mohammad on Facebook sentenced to death
Jennifer Lopez and Iggy Azalea's 'Booty' music video is just a load of butts
Friends 20th anniversary: Alison Jackson photographs reunited cast
The Beatles biographer reveals exclusive original manuscripts of some of the best pop songs ever written
Friends 20th anniversary: The highs and lows of the cast's careers since 2004
Friends 20th anniversary: Six things we wouldn't have without influential comedy series
Scottish independence referendum: A nation divided against itself
Scottish referendum results: Cross-party consensus collapses amid Tory-Labour spat on the 'English question'
Scottish independence: David Cameron is becoming the 'George Bush of Britain'
Russia freezes Ukraine into submission: Kiev admits country doesn't have enough fuel for winter
Archbishop of Canterbury admits doubts about existence of God
Portuguese academic says British are 'filthy, violent and drunk'

domain: artistic


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NEW YORK (CBS.MW) - U.S. stocks traded flat-to-lower Thursday as strong earnings from a number of companies, including Citigroup, Texas Instruments and Apple failed to quell concern over the prospect of higher interest rates in the near future. See full story.
Apple shares surge on strong sales
SAN FRANCISCO (CBS.MW) -- Apple Computer shares surged 9 percent Thursday morning after the company posted a three-fold increase in its profit, led by sales of iPod digital music players and notebook computers. See full story.
Citigroup first-quarter profit rises, topping estimate
NEW YORK (CBS.MW) -- Banking giant Citigroup said Thursday that its first-quarter earnings rose 29 percent on investment-banking strength and growth in consumer lending. See full story.
Mortgages: U.S. mortgage rates continue upward push
CHICAGO (CBS.MW) -- U.S. mortgage rates rose for the fourth straight week on the heels of positive economic news, pushing the national average on the benchmark 30-year loan to 5.89 percent from 5.79 percent a week earlier, Freddie Mac said Thursday. See full story.
Economic Report: U.S. jobless claims highest in a month
WASHINGTON (CBS.MW) - U.S. weekly jobless claims rose to their highest level in a month in the week ending April 10, the Labor Department said Thursday. See full story.
Net Sense: The latest mania hits security Internet shares
SAN FRANCISCO (CBS.MW) - What do you get when you combine the prospects of the Internet and homeland security in one public company? See full story.
Gender Gap: Search for female Viagra a complex undertaking
SAN FRANCISCO (CBS.MW) -- Imagine if Senator Elizabeth Dole went on the air to hawk the female equivalent of Viagra, the blockbuster male impotence drug first made famous by her husband's TV testimonial. See full story.


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More of a light-hearted post tonight. But first a Book 3 update.
I’m down to 2 chapters left to write for the book. 2 chapters! I’m sure you can feel the excitement crackling in the air. 🙂
The current chapter I’m tackling was one I formerly abandoned due to character difficulties. I’ve realized I just don’t know enough about a couple of newer characters, so before diving back into writing, I’m going to fill out some character questionnaires with questions like: “Your character’s in a crisis! Who’s the first person they turn to?”, “What do they love most about themselves?” and “When do they doubt themselves? What makes them do so?”
As you can see, these aren’t fluff questions. They get right down to the heart of who a character is. Hopefully, answering them will get me unstuck.
Now on to the random trivial thing that inspired this blog post: today’s mail. 😉
A few years ago, before I published my first book, I started a business called Knights Press. It isn’t really a business in the usual sense of the word; it’s really just an entity that exists for tax purposes. Still, it officially exists as a company and as such I get a certain amount of junk mail associated with it.
Along with the usual credit card offers, I also regularly receive a Uline catalogue. (And on a random tangent, I’ve just discovered courtesy of spellcheck that you can spell that last word as catalog or catalogue. Never knew that…) Uline—as far as I can tell—is a specialized form of Amazon that will sell you anything having to do with business/office supplies. Just flipping through the 787 page catalogue I find:
Stretch wrap machines (Now those look cool.)
Duct tape in a variety of colors (Pink, anyone? ;))
Trash liners (I could use those. I burn through a lot of paper…)
Steel strapping tools (No idea. Maybe they’re for tearing your book to shreds when you’re upset about your writing…?)
Special Handling Labels (I like the fun ones like “Live Animals” and “Refrigerate Upon Arrival”. Can’t you picture the fun you could have with those?)
And of course there’s every kind of box, mailer, envelope, bag, etc. that you could want.
The thing that amuses me most, though? The address on the catalogue:
Manager Shipping Dept
Knights Press LLC
Gosh, a shipping department! Didn’t know I had one. 😉 Seems appropriate, though. I am obsessed with organizing…


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Shea Glover, a high school student conducted a social experiment on the subject of beauty. The student wanted to see how different people react when they are told that they are beautiful. Every individual was made to stand in front of a camera and was told by Shea that he was capturing extraordinary. Shea Glover did disclosed in his YouTube description that he was actually trying to capture something beautiful, but how the people react astonished him. Here are few images that show the reaction of these individuals.
Watch this amazing video:
Please do share this awesome reaction of these individuals on Facebook, Twitter, and Pinterest.


text:
Publish. Read. Get Read.
Random First Lines:RAPPER KSD IS CONSIDERED THE FIRST INDIAN GANGSTER RAPPER BY REVERBNATION.COM AND MTV ARTISTS. AN ONLINE SENSATION THE RAPPER KSD AT A YOUNG AGE... » Read
Relationships don't always go as planned. Reality is, relationships are like dragons, they are unpredictable and cannot be tamed. But when things do go wrong, do you just give up and walk away or do you try again? Do you let yourself fry in dragon fire or do you quench the burning feeling in...
Short Story | Updated May 21, 2014 | Reads: 80 | Comments: 3 | Likes: 1
The introduction to Peter Fitch's life and friends and how his life leads up to his attack by the "beast of the streets".
By S Narwan
14 year-old Simran was left at her grandmother's doorstep as a baby. She grows up not knowing the circumstances of her complicated past. This is Simran's journey as she discovers the ugly secrets of her life.
Set in rural India, her life is contorted by twsited culture.
Novel | Updated May 20, 2014 | Reads: 9 | Comments: 0 | Likes: 0
Hazel has always thought herself to be nothing special. But when a ghost from her past appears, will all that change?
Novel | Updated May 20, 2014 | Reads: 20 | Comments: 0 | Likes: 0
By Death The Kitty
This is a creepypasta that i wrote yesterday, so hope you enjoy it!
(i'm not here to destroy any childhood, but this is normal to happen, lots of pokemon creepypasta as been wroten)
Novel | Updated May 20, 2014 | Reads: 10 | Comments: 0 | Likes: 2
It is a dramatic story between a boy and his mother.
Short Story | Updated May 20, 2014 | Reads: 34 | Comments: 0 | Likes: 0
By Kameron Cross
In this sequel to the novel "School Target", Kameron Cross goes to Poughkeepsie Middle School in the 2009-2010 school year to forget about the events that happened in the 5th grade. History repeats itself when Kameron run into old bullies and new bullies.
Based On A True Story. (Although the...
By The Exuberant Liar
Adventures of a liar, starting from his childhood, still haven't ended yet.
Novel | Updated May 17, 2014 | Reads: 2 | Comments: 0 | Likes: 0
A soap opera series that dwells into the lives of the people living in the town of Sunset Fall (written in a tv script format) ^_^
Novel | Updated May 16, 2014 | Reads: 0 | Comments: 0 | Likes: 0
"I studied how the birds interacted with each other and how the flowers hadn't blossomed yet, but something in particular caught my eye, a boy approaching my front door. A boy from my dreams."
Playing the instrument and being in love. Only to have drama in the end.
35 conestants risk there lives in order to win 3 million dollars! They face dangerous changes, and heart break, back stabbing, romance, betrayal, nasty foods, hot places, mean people, tricky people, and all kids of other things on this Mysterious ISLAND OF AGONY. This is a book you do not want ...
Novel | Updated May 16, 2014 | Reads: 9 | Comments: 1 | Likes: 0
By Tyrone Kony
This original story follows the struggles of big-time Kenyan CEO Tyrone Kony as he ventures across the dangerous unforgiving continent of Africa in search of his wife who is stranded in America. He will meet people of many different backgrounds as he journeys across the continent including...
Jane lives in Java. Jane makes a baby with Jack- a problematic baby. Jane drowns the baby..... you must read on
This is the final edited version of what I want to be the first book of the series CROSSROADS. Three protagonist, Lionel, Chloe, and Brent all are going through the complications of life. Where they all have a common ground of understanding and peace is with each other.


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Which city is cheaper, Seattle or Savannah?
These are the overall average travel costs for the two destinations.
Should I visit Savannah or Seattle? This is a common question asked by many travelers. By figuring out which city has activities that align with your interests along with knowing which is more affordable, you'll understand where you can get more bang for your buck. So, let's dive into the details and the data, which all comes from actual travelers.
Savanah is a reasonably priced city by U.S. standards. With a wide range of accommodation and food options, it's possible to experience this historical city on a cheaper budget, or, if you like, to live it up in luxury without spending an inordinate amount of money.
The oldest city in the state of Georgia, Savannah sits right on the Savannah River, a historic commercial port dating back to the Thirteen Colonies. The old port of the city still lies along this river, paved in traditional cobblestone roads and radiating with old southern charm. Savannah is also known for its many small parks, tunnels of oak trees and magnolias draped in southern moss, romantic horse-drawn carriages, as well as some of the most ornate antebellum architecture to be found in the south.
Whether you are interested in the past of a historically prosperous seaport or wish to enjoy the enchanting atmosphere that it still holds, Savannah is a quaint destination full of beauty with an arsenal of historic appeal to match.
Situated on the Puget Sound in the state of Washington, Seattle is the largest city in the United States Pacific Northwest. It's a beautiful city surrounded by the water and mountains and filled with evergreen trees. It's also the home of some famous American institutions including Starbucks Coffee, Amazon, and Microsoft. The population of almost 700,000 continues to grow. As of 2014, the city was considered the fastest growing major city in the United States. The entire metropolitan area has about 3.6 million residents, making it the 15th largest metro area in the US. The natural beauty, growing economy, and educational base give Seattle a youthful vibe that keep the city young and energetic.
These are the overall average travel costs for the two destinations.
The average daily cost (per person) in Savannah is $128, while the average daily cost in Seattle is $156. These costs include accommodation (assuming double occupancy, so the traveler is sharing the room), food, transportation, and entertainment. While every person is different, these costs are an average of past travelers in each city. What follows is a categorical breakdown of travel costs for Savannah and Seattle in more detail.
Looking for a hotel in Savannah or Seattle? Prices vary by location, date, season, and the level of luxury. See below for options and compare which is best for your budget and travel style.
Kayak helps you find the best prices for hotels, flights, and rental cars for destinations around the world. Compare prices for multiple destinations when planning your next trip.
Some specific examples of transportation prices in Savannah:
Here are some examples of typical transportation prices from actual travelers in Seattle:
Some specific examples of transportation prices in Seattle:
Prices for flights to both Seattle and Savannah change regularly based on dates and travel demand. We suggest you find the best prices for your next trip on Kayak, because you can compare the cost of flights across multiple airlines for your prefered dates.
Also, here are some specific examples of food and dining related activities in Savannah.
Some typical examples of dining costs in Seattle are as follows:
Also, here are some specific examples of food and dining related activities in Seattle.
Some typical examples of activities, tours, and entrance ticket prices in Savannah are as follows:
Some specific costs of activities, tours, and entrance tickets for Savannah are as follows:
Some specific costs of activities, tours, and entrance tickets for Seattle are as follows:
Some specific costs for nightlife related activities in Savannah:
Here are a few nightlife and alcohol tours and activities from local tour providers in Seattle:
When we compare the travel costs of actual travelers between Savannah and Seattle, we can see that Seattle is more expensive. And not only is Savannah much less expensive, but it is actually a significantly cheaper destination. So, traveling to Savannah would let you spend less money overall. Or, you could decide to spend more money in Savannah and be able to afford a more luxurious travel style by staying in nicer hotels, eating at more expensive restaurants, taking tours, and experiencing more activities. The same level of travel in Seattle would naturally cost you much more money, so you would probably want to keep your budget a little tighter in Seattle than you might in Savannah.
Both destinations experience a temperate climate with four distinct seasons. And since both cities are in the northern hemisphere, summer is in July and winter is in January.
Both Seattle and Savannah are popular destinations to visit in the summer with plenty of activities. Also, many visitors come to Seattle in the summer for the beaches, the hiking, the city activities, the music scene, and the family-friendly experiences.
In July, Savannah is generally a little warmer than Seattle. Temperatures in Savannah average around 82°F (28°C), and Seattle stays around 67°F (19°C).
It's quite sunny in Seattle. The sun comes out a lot this time of the year in Savannah. Savannah usually receives less sunshine than Seattle during summer. Savannah gets 267 hours of sunny skies, while Seattle receives 313 hours of full sun in the summer.
It's quite rainy in Savannah. In July, Savannah usually receives more rain than Seattle. Savannah gets 7.9 inches (200 mm) of rain, while Seattle receives 0.9 inches (22 mm) of rain each month for the summer.
Both Seattle and Savannah during the autumn are popular places to visit. Furthermore, most visitors come to Seattle for the hiking trails, the city's sights and attractions, the shopping scene, the music scene, and the natural beauty of the area during these months.
Savannah is much warmer than Seattle in the autumn. The temperature in Savannah is usually 68°F (20°C) in October, and Seattle stays around 54°F (12°C).
It's quite sunny in Savannah. In the autumn, Savannah often gets more sunshine than Seattle. Savannah gets 223 hours of sunny skies this time of year, while Seattle receives 143 hours of full sun.
Savannah usually gets less rain in October than Seattle. Savannah gets 2.8 inches (71 mm) of rain, while Seattle receives 3.3 inches (83 mm) of rain this time of the year.
The winter attracts plenty of travelers to both Savannah and Seattle. Furthermore, the winter months attract visitors to Seattle because of the museums, the shopping scene, the theater shows, and the cuisine.
In the winter, Savannah is much warmer than Seattle. Typically, the winter temperatures in Savannah in January are around 49°F (9°C), and Seattle is about 42°F (5°C).
Savannah usually receives more sunshine than Seattle during winter. Savannah gets 176 hours of sunny skies, while Seattle receives 67 hours of full sun in the winter.
Seattle receives a lot of rain in the winter. In January, Savannah usually receives less rain than Seattle. Savannah gets 2.9 inches (74 mm) of rain, while Seattle receives 5.4 inches (136 mm) of rain each month for the winter.
The spring brings many poeple to Savannah as well as Seattle. Additionally, the beaches, the activities around the city, and the natural beauty are the main draw to Seattle this time of year.
In April, Savannah is generally much warmer than Seattle. Temperatures in Savannah average around 66°F (19°C), and Seattle stays around 51°F (11°C).
The sun comes out a lot this time of the year in Seattle. People are often attracted to the plentiful sunshine in Savannah this time of the year. In the spring, Savannah often gets more sunshine than Seattle. Savannah gets 275 hours of sunny skies this time of year, while Seattle receives 212 hours of full sun.
Savannah usually gets more rain in April than Seattle. Savannah gets 2.9 inches (74 mm) of rain, while Seattle receives 2.5 inches (64 mm) of rain this time of the year.
|Temp (°C)||Rain (mm)||Temp (°C)||Rain (mm)|
|Jan||49°F (9°C)||2.9 inches (74 mm)||42°F (5°C)||5.4 inches (136 mm)|
|Feb||52°F (11°C)||2.9 inches (73 mm)||45°F (7°C)||4 inches (102 mm)|
|Mar||59°F (15°C)||4.4 inches (112 mm)||47°F (9°C)||3.8 inches (96 mm)|
|Apr||66°F (19°C)||2.9 inches (74 mm)||51°F (11°C)||2.5 inches (64 mm)|
|May||73°F (23°C)||4.2 inches (107 mm)||57°F (14°C)||1.9 inches (47 mm)|
|Jun||79°F (26°C)||5.9 inches (150 mm)||62°F (17°C)||1.6 inches (40 mm)|
|Jul||82°F (28°C)||7.9 inches (200 mm)||67°F (19°C)||0.9 inches (22 mm)|
|Aug||81°F (27°C)||6.5 inches (164 mm)||67°F (19°C)||1.2 inches (31 mm)|
|Sep||77°F (25°C)||5.6 inches (141 mm)||62°F (17°C)||1.9 inches (49 mm)|
|Oct||68°F (20°C)||2.8 inches (71 mm)||54°F (12°C)||3.3 inches (83 mm)|
|Nov||59°F (15°C)||1.9 inches (49 mm)||47°F (8°C)||5.7 inches (144 mm)|
|Dec||52°F (11°C)||3.3 inches (83 mm)||42°F (6°C)||6 inches (152 mm)|
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domain: travel