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|Are you DELIGHTED yet?|
For a repertory performance, this Elisir d’amore would not have been all bad. The singing is decent and the story happens, though the beats fall haphazardly. But this was a new production for the Met’s opening night, which requires confronting the reality that a lot of people thought that making this thing from scratch was a good idea, and put a lot of time, craft, and money into it.
The ideal seems to have been to create something as mainstream and inoffensive as possible. In practice, this means the production has all the appeal and originality of a suburban shopping mall (whose multiplex probably plays The Met Live in HD). There’s a ritual aspect to opera, particularly live performance. There are certain thrills we want to experience, together, over and over. But new productions are for, you know, new stuff, and to come up with something as cookie cutter as this you have to be really actively opposed to creativity.
Donizetti, L’elisir d’amore. Metropolitan Opera opening night, 9/24/2012. New production (premiere) directed by Bartlett Sher, sets by Michael Yeargan, costumes by Catherine Zuber, lights by Jennifer Tipton. Conducted by Maurizio Benini with Anna Netrebko (Adina), Matthew Polenzani (Nemorino), Mariusz Kwiecien (Belcore), Ambrogio Maestri (Dulcamara), Anne-Carolyn Bird (Giannetta)
L’elisir is a human comedy that has to find a way to balance sincere emotion with slapstick, and deal with the fact that its hero Nemorino is, well, not the sharpest tool in the shed. (I think this is why most productions keep the setting rural and full of peasants. Those country people are dumb!) This production preserves the traditional rustic Italian setting, though the set is blown up to almost Zeffirellian proportions. The stage is framed in a false proscenium that fulfills its promise to portray only a storybook—these are faultlessly clean and well-dressed peasants, with a generous touch of opera’s favorite time period, Slutty 18th and 19th Century (it’s like the 18th or 19th century, only with more cleavage). There seem to be both farm folks and town folks, but I couldn’t figure out why. Anna Netrebko’s Adina does wear a top hat, and an outfit with a red skirt and belt that led some people in front of me to conclude that she was “a gypsy” (sic).
Many of the sets are flat cutouts. The maze of buildings, wheat and many unidentified objects reads very badly from the bird’s eye view of the Family Circle, I can’t really tell you much more about what it looks like. (To paraphrase Mitt Romney, those trees are not the right height). But while the sets speak of Italy, the lighting plot is of Sweden in December. Gratuitous follow spots pop on and off randomly, and it always looks like sunset. I tried to figure out how much time was passing between scenes and what time of the day it was supposed to be, and I had to give up.
Sher portrays Adina and Nemorino on close terms from the start, getting physically intimate with each other even before the elixir is involved. But it’s not consistent, and Sher prefers everyone to constantly run around and fall over a lot rather than anything genuinely emotional or constructing a convincing through-line. And since they started getting in each other’s faces, unless you have some detail there’s nowhere you can really go. (I was in the Family Circle, FWIW.) But for all the broadness there is little that is funny here. And if you’re going to make this a psychological drama you have come up with characterizations a little more distinctive than these. Belcore is not as over-the-top as usual but nor is he anything more than a guy who comes on and sings an aria. I guess you can choose to pass up comedy if you like, but to have such wonderful opportunities as Dulcamara’s aria, Nemorino opening the elixir bottle, and the gondola girl song pass with hardly a laugh makes the whole thing even more confusing and bland.
This may have been partially due to a certain lack of star wattage. Anna Netrebko is a treasure but has a hard time wrapping her increasingly big, dark voice around this light part. While the results were sometimes interesting, and the sound is pure gorgeous, her pitch went flat sometimes and this voice in this role is, despite her aggressively flirty acting, matronly. As for that top hat, I don’t know. It makes no sense, though it isn’t alone in that regard. The stage desperately needed lighting up, and she wasn’t quite enough to do it.
Based on Matthew Polenzani’s sound, you’d think he should be more famous than he is. But considering the whole performance his place seems, as cruel as this might sound, about right. He has lovely technique and smooth liquid tone, sounds Italianate enough, is musically tasteful, and can sing piano like nobody’s business. But he is completely, utterly lacking in charisma. (That only one of these photos features him is not my fault but rather the Met website’s. Maybe that means something.) Nemorino might not be a glamorous guy but he’s the hero and you have to be rooting for him. Polenzani is just this dude singing, and his dramatic ritardando at the end of “Una furtiva” was immaculate and accomplished yet empty.
Mariusz Kwiecien sang Belcore cleanly but sometimes has a bit of strain in his voice in the higher ranges. Ambrogio Maestri is a big man with a big voice and is very Italian and would thus seem ideal for Dulcamara, but despite booming it out just fine (with an excellent upper register) never seemed to have the personality to match his other attributes. Anne-Carolyn Bird’s Giannetta chorus scene was beautifully done, featuring several of the most elegantly shaped phrases of the night.
Maurizio Benini kept to the tradition that Elisir d’amore should only be conducted very, very badly (see my records on this—yeah, I like this opera and go see it a lot, we go back, Elisir and I, and for the record my production was cuter than this one and I still have the bottle of elixir sitting on my bookshelf). Coordination was faulty in the chorus preceding Dulcamara’s entrance, the tricky concertante that closes Act 1, and several other spots. In general Benini seemed content to let the singers do their thing and not make anything too exciting or dramatic.
Alas, this seems to have been everyone’s mission. Doing anything that hadn’t been done before doesn’t seem to have been on anyone’s mind. It’s less twee than most of Sher’s other work for the Met, but it’s slapdash, superficial, and hella boring. I think I’d actually prefer to see Otto Schenk’s Vienna production, which isn’t any more innovative but at least doesn’t bury its characters in sets and shadows. If opening night sets the tone for the rest of the year it’s going to be a long, long season.
On the way home I tried to think what would make me want to see this thing again and I came up with the following casts:
Marina Poplovskaya and Lance Ryan
Simone Kermes and Johan Botha
Nadja Michael and the sax/flute player from the subway
You might gather I think this production needs an infusion of weird energy. Putting together a certifiably insane HIP diva and an immobile Heldentenor might not be kind to Donizetti but it would sure be something different. Any further ideas?
Should you wish, this production is on for the next while and on HD later.
Photos copyright Ken Howard/Met Opera.


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La Palma is a small town with easy access to all that Fullerton offers. It’s just 6 miles away, so it makes for an ideal place where you can live or work without having too much travel time involved. La Palma may be quiet, but there are plenty of opportunities around if this suits your needs more than anything else. There are approximately 15834 people who call this neighborhood home.
La Palma, CA, is a great place to live if you look for an excellent livability score. It is ranked 157th out of all cities in California and 4992nd among communities across America. If that’s not enough reason alone, consider how affordable housing may be available in your desired area. La Palma is one of the best neighborhoods in all of California because it offers everything you need. This area ranks better than 82%of its surrounding areas.
In La Palma, CA, the cost of living is 15% higher than the California average and 62% greater than the California average. When you factor in the housing, the housing prices are also 176% higher on average.
La Palma is a little paradise where residents can enjoy peace and tranquility. The low crime rates are one of the many reasons people love to call this town their home, but there’s more than just great weather that makes it an appealing destination for visitors from all over. The city’s crime rates are 12% lower than average, and violent crimes are 58% less frequent. In La Palma, you have a 1-in-49 chance of becoming the next victim of crime, which is better than 49% of the cities in America where you’re at risk for crime.
Incomes in La Palma are much higher than average. The median household income is about 51% greater than the national amount. The city’s 16% more per capita income compared to other places across America makes it an excellent place for those looking to start their career or expand upon what they already have.
La Palma is a city with great opportunities for those willing to work hard. The unemployment rate here has been shown time and again as 16% lower than the national average, making it an excellent location if you’re looking into starting your own business or want some extra cash on hand every month. The median income for males in La Palma is 41% higher than females.
The test scores in La Palma are average compared to the rest of California and the country. There are five public schools within city limits. The data shows that 90.6% of people in La Palma have completed 8th grade, which is a very high rate for the area. 90% of the population has completed high school, while 41.9% have earned their bachelor’s degree or higher qualification.

domain: geography


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This was a great week, since I got back to cooking "better" (last week I had some slack due to anniversary)
No more time to calculate costs per meal, but with our grocery lately, you can tell they are not expensive! =)
Breakfast: French Toast Bake.
(Bread, Cream cheese, Syrup, eggs, milk, raisins)
This is a GREAT dish when you have left over cream cheese (which we had from Panera bread).
Sweet Sour Fish (another yum!)
This dessert, with cheap apples, only cost me $1.84 to make (right, with gas, $2)
Anniversary dinner treat by parents
Stir-fry diced tofu with minced pork, carrots and beans
(our dear old $0.20 Suddenly pasta Salad can be real pretty)
Chicken Thighs, peas, mushroom and majoram
Stir fry Cabbage and carrots
Baked Pasta with Cream of Chicken soup
(this made with our $0.50 Ronzoni Smart Pasta)

domain: food


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NFL Viewership Continues Rocky Start To '16 Russo Re-Ups With SiriusXM For Three Years Colts Announcer Apologizes For Expletive Saints, Falcons Display Unity After Anthem Debate Audience Puts "MNF" At New Low ESPN Fires Back At FS1's Repeated Jabs Top Rank Annouces Pacquiao-Vargas Broadcast Team NHL Debuting New Technology At WCOH Feinberg Files Amicus Curiae Brief For MASN Social Studies: Adidas PR Dir Michael Ehrlich
FOX ENDS FIRST NFL SEASON WITH BETTER THAN EXPECTED NUMBERS
Published January 17, 1995
The NFL on Fox finished only six percent below CBS's '93 numbers for the NFC package. Most had projected a 10-15% decline. ATLANTA CONSTITUTION TV columnist Prentis Rogers: "'Fox NFL Sunday' was clearly a success, and with [Jimmy] Johnson in the mix presumably for the next three years, the future is bright" (ATLANTA CONSTITUTION, 1/16). In Minneapolis, Rachel Blount writes that Fox pumped "broadcasts full of fun and energy without distracting from the games. ... Howie Long is clearly the broadcasting rookie of the year." Blount panned Fox's promotions (Minneapolis STAR-TRIBUNE, 1/16). In Toronto, Rob Longley: "The network has mixed the best of what was CBS Sports with the cutting edge of '90's TV technology" (TORONTO SUN, 1/16).

domain: sports


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PRAXIS is an unfinished story written by Dan Hunker and Jennifer Hunker. An experiment into parallel universes leaves a small team stranded in a strange and bizarre world unlike Earth with no memory of how they got there and no memories of their own. The only thing they have to go on is one little name tag attached to their jumpsuits…which is inscribed with only one word…“PRAXIS”.
This is a concept soundtrack based on that story with emphasis on orchestration and synthesis. The longer tracks were designed with phases in mind for an interactive experience depending on the situation the player was in. It was a hugely creative project for me and I'm very happy I can share it now. Enjoy the ride!
released 12 October 2011
Album art created by myself.
Character sprite by Jennifer Hunker
'Axis of Definition' and 'Apraxia' were awarded semi finalist positions in the UK Songwriting Contest.
all rights reserved
feeds for ,

domain: entertainment


The National Institute of Building Sciences is advising the owners of the nation’s estimated 1,500 professional, college and community sports venues to join in a collective effort to reduce energy and water consumption—and utility bills.
With several large, grid-scale battery-storage facilities opening in quick succession in Southern California, pundits say the state has taken a leading role in developing infrastructure to hold renewable power generated during low-demand periods, using it to supply customers during peak hours.
Roadways that communicate with and charge the electric vehicles that drive on them. Autonomous trucks that deliver freight faster and safer, with less stress on highways and bridges. These are just a few of the innovative transportation concepts, once considered impossible, that could become reality in the near future.
As those on the leading edge know, progress in the buildings sector does not come easily. But that doesn't stop innovators from working diligently to increase the sustainability and resilience of buildings and decrease their carbon footprints while trying to find ways to boost construction quality and building-team productivity.
Concrete’s large carbon footprint—that is, the amount of carbon dioxide emitted during the cement manufacturing process—is estimated to be 5% of industrial CO2 emissions, a source of concern in the battle against human-caused climate change.
Offshore wind seeks a place in the U.S. power mix, with the start-up imminent of a 30-MW Rhode Island wind farm, America’s first. European competitors and oil-sector veterans are bringing technology and cost efficiency.


Native Grasses Researched
NOBLE - The unrelenting rains of late spring were just recent memories on a mostly clear summer day.
Under the June afternoon sun, the dry grasses and plants on T.H. Milby's prairie dog tree farm south of Noble crunched under soles of visitors.
On 74 acres, Milby is participating in a native grass experiment that can be found on farms from Canada to Mexico.
He also has given up part of his land to the Oklahoma Department of Wildlife's prairie dog relocation program.
Two years ago, prairie dogs were causing some problems near Lake Overholser.
Wildlife officials relocated some of the prairie dogs to Milby's land where he grows some species of perennial grasses that are native to North America.
There were five adult prairie dogs and 14 pups this spring.
Milby, a retired University of Oklahoma botany professor said the prairie dog town was "beautiful. " But he has not seen a prairie dog in several weeks.
After the spring flooding, he fears the worst.
The holes where the dogs lived are still in the ground, he said, pointing to one dirt entrance to a prairie dog hole. The heavy spring rains flooded the holes and collapsed the dog tunnels. He said he found one drowned prairie dog.
He hopes more can be relocated on his land one day.
Meanwhile, he is watching four species of plants that once grew abundantly.
Milby is participating in a perennial root project promoted by the Land Institute of Salina, Kan.
The four plants he grows are eastern gama grass, mammoth wild rye, Illinois bundleflower and Maximillian sunflower.
Milby planted in specific plots last year that are marked by mowed borders. He is waiting for some to flower so he can identify them this year.
The Land Institute, a private nonprofit research group is trying to find plants that can help reduce erosion and be useful in agriculture to reduce use of pesticides, irrigation and nitrogen fertilizers without sacrificing high yields.
Perennial plants return each year, as opposed to annual plants that are replanted. If a farmer does not have to plow and turn the soil every year, erosion can be avoided, Milby said.
He said sunflowers are annual plants and expensive to cultivate.
But the Maximillian sunflowers are perennial and could someday possibly be used for their seed and oil, he said.
Near a small pond, Milby has a patch of the rare eastern gama grass.
Gama grass is considered "ice cream" to cows, because they will eat it before any other grass, Milby said.
Overgrazing has made gama grass more scarce.
Milby found a cluster growing near the Norman Wastewater Treatment Plant and he kept some of the seeds.
The perennial grass holds soil in place year after year.
If its roots are plowed under, erosion from water and wind is tough to contain, he said.
Grass is not the only subject of research on his land south of Noble. He has a lot of landscape trees and a nest of bluebirds.
Milby lifted the front door of a birdhouse. Inside is a bluebird nest, part of another research project. Featherless newborn chicks opened their mouths wide.
"They must have hatched today," Milby said. BIOG: NAME:
Archive ID: 615972


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Build Your Workforce with an Apprenticeship Program
One effective way for manufacturers to develop skilled workers is through apprenticeship programs, which are again taking hold among manufacturers in the U.S. as they look for ways to address their workforce needs.
Per the U.S. Department of Labor, apprenticeship is an -earn and learn- training model that combines work-based learning with related classroom instruction using the highest industry standards. This approach formalizes work-based learning so workers know how to progress toward their career goals, and companies know who is on the path toward promotion into new positions or to replace retiring workers.
Apprenticeships may be registered or unregistered. Registered Apprenticeships are managed by the U.S. Department of Labor while unregistered apprenticeships are managed by companies in direct partnership with training centers, technical schools or community colleges with the goal of meeting their individual needs.
To learn more about apprenticeship programs, take a look at the Manufacturing Institute’s Employer’s Playbook for Building an Apprenticeship Program.

domain: economics


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Stressed? Take a hike!
Before gas prices became prohibitively expensive, I, like many people, would respond to high levels of stress by hopping in my car and going for a drive. It was a simple but effective method for temporary relief: put on some music, find a country road, or at least a road without further stress-inducing traffic, and drive until my blood pressure dropped to an acceptable level. These days, however, it might be cheaper to just pop into a psychologist’s office for a walk-in therapy session than to burn enough fuel to reduce stress. Besides, I don’t own a car anymore. So when I get stressed these days, I go for a walk.
Turns out I should have been going for walks all along. At least, that’s what a study by a bunch of researchers from the UK, Finland, and Spain, in press at the Journal of Environmental Psychology, suggests. The researchers took a bunch of measurements – some self-report measures like cognitive function and mood, along with salivary cortisol and ambulatory heart rate as physiological measures of stress – and then sent their participants on a thirty-minutewalk in one of three environments: a low-traffic urban area, a “green” natural environment (a “country park”), or a “blue” natural environment (a “footpath beside a canal with a range of natural vegetation”). Once the walk was over, they retook the measurements twice, first immediately and again thirty minutes later.
Here’s what they found: going for a walk in any of the three environments improved mood and cognitive function, and reduced cortisol levels, though the positive effects were more persistent for the “natural” environments than the urban one. There were small differences between the “blue” and “green” environments, but they weren’t statistically significant. So, if you need immediate relief from stress, go for a walk wherever you are (as long as you’re not in a stress-inducing environment), but if you want the relief to last, find a park.
Front page image: The Barton Creek Greenbelt trail covers a wide range of . Photo: Flickr user Brandon Turner, CC licensed. (Souce)

domain: psychology


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This happened in another country, at a time of great promise. When people were slowly beginning to accept that happiness was possible. And still, they were cautious, suspicious of their giddy expectations.
I have no memories of the girl that was me in this picture but I remember my mother braiding my sister's hair in the mornings. I can see my sister sitting behind my father on the bicycle carrier, wrapping her arms around him. I remember sucking my thump while watching him mixing our breakfast muesli.
I can see my parents kissing at the top of the stairs, my mother leaning against the bannister, her head falling backwards. I remember a long tanned arm reaching down to stroke my hair, shiny gold bangles jingling.
I remember the smell of my baby brother, holding my breath, terrified, as I watched my father lifting the new baby up higher and higher and then giggling with relief.
I know from looking at this picture that they tried really hard for a while.
But I don't remember the girl on the left at all.

domain: literature


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About the show
Playing tracks by
David Guetta, Kid Cudi, Yolanda be cool, David Guetta ft Kelly Rowland, Usher and more.
Stepping back into the mainstream top 40 realm, this is a compilation of some pop remixes I put together a while back. Enjoy! Dance!

domain: artistic


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KNOW ALL MEN BY THESE PRESENTS, That we Joseph Smith Jr & of the county of and State of are held and firmly bound unto Calvin C. Pendleton of the county of and State of his heirs and assigns in the sum of Two hundred and fifty dollars for the payment of which well and truly to be made we bind ourselves, our heirs, executors and administrators, firmly by these presents.
NOW THE CONDITION OF THE ABOVE OBLIGATION IS SUCH, that whereas, the said Joseph Smith Jr & have this day sold unto the said Calvin C. Pendleton a certain lot of ground situated, lying and being in the county of and State of , and described on the plat of the Town of as being Lot No. in Block No. and received payment for said lot note of hand bearing even date herewith, for the sum of dollars, and payable as follows. in Lot No One in Block No one hundred and thirty nine commencing at the South East corner of said Block running thence North seven rods thence West twelve rods, thence South seven rods thence East twelve rods to the place of beginning containing eighty four rods, more or less, and received in payment for said lot Two notes of hand bearing even date herewith for the sum of one hundred and Twenty five dollars and payable as follows. The first for twenty five dollars on demand The second for one hundred dollars on the first day of April A. D. 1841
with interest for each and every note to be paid annually.
Now if the said Calvin C. Pendleton his heirs, executors, or administrators shall well and truly pay or cause to be paid, the amount of said notes with such in terest as may accrue thereon, according to the tenor and effect thereof, when due, we the said Joseph Smith Jr & bind ourselves and heirs, executors and administrators, to make or cause to be made, a good and sufficient Deed for the above described lot to the said Calvin C Pendleton, his heirs or assigns and then this Bond to become null and void, otherwise to be and remain in full force and virtue.
Given under our hand and seal this first— day of August in the year of our Lord one thousand eight hundred and thirty nine
Joseph Smith Jr LS
Acknowledged in presence of

domain: finance


text:
Standing afar, bare and tall,
I spy the lonely winter tree,
Lacking severe impetus,
But digging deep to subsist.
Solace it finds in cycles,
A succession of seasons,
Varied are its reasons to live,
Unlike me, hardly utopian.
Not long ago, bathed in splendor,
Colors hues and thriving blossoms,
Spring is its ultimate vindication,
Belief in a new and bright morrow.


The BMW i4 M50 is an impressive electric vehicle that stands out for its exceptional performance and advanced features. With a battery size of 83.9 kWh, this sedan offers a remarkable driving range of between 315 and 620 km, depending on various factors such as driving conditions and speed. Its battery efficiency of 186 Wh/km ensures that you can enjoy a long drive without worrying about running out of power.
When it comes to acceleration, the BMW i4 M50 does not disappoint. It can go from 0 to 100 km/h in just 3.9 seconds, thanks to its powerful 875 horsepower engine. With a top speed of 225 km/h, this electric sedan delivers an exhilarating driving experience that is sure to impress.
In addition to its performance capabilities, the BMW i4 M50 is designed with comfort and convenience in mind. It features a spacious interior that can comfortably accommodate up to 5 people, making it an ideal choice for families and those who enjoy traveling with friends. The sedan also comes equipped with a type 2 charging port, allowing for quick and easy charging wherever you go.
When it comes to pricing, the BMW i4 M50 is available at a starting price of $77, with various options and upgrades available. Its real range of 435 km ensures that you can enjoy a long trip without needing to recharge frequently, making it a practical choice for daily commuting or road trips.
In summary, the BMW i4 M50 is a high-performance electric sedan that combines power, efficiency, and luxury. With its impressive specs and advanced features, it offers a driving experience that is both thrilling and comfortable. Whether you're looking for a practical daily driver or a weekend getaway vehicle, the BMW i4 M50 is definitely worth considering.
The BMW i4 M50 is an electric sedan model that was first released in November 2021. It features a powerful battery with a size of 83.9 kWh, allowing for an impressive model range between 315 and 620 kilometers. With its spacious body and comfortable seating for up to five people, the BMW i4 M50 combines luxury with eco-friendly driving. It has a top speed of 225 km/h and can accelerate from 0 to 100 km/h in just 3.9 seconds. The real range of the BMW i4 M50 is around 435 kilometers, offering a practical and efficient driving experience. When it comes to pricing, the BMW i4 M50 starts at a competitive starting price of 77,875 dollars. It is equipped with a type 2 charging port and has a battery efficiency of 186 Wh/km, ensuring efficient use of energy. Overall, the BMW i4 M50 offers a thrilling driving experience combined with the benefits of electric power.
The BMW i4 M50 is a powerful electric sedan that offers impressive speed and performance. Equipped with a 83.9 kWh battery and a powerful electric motor, the i4 M50 can accelerate from 0 to 100 km/h in just 3.9 seconds. With a top speed of 225 km/h, this model is designed for exhilarating drives. Its model range varies between 315 and 620 km, offering ample range for long-distance travel. The i4 M50 seats 5 people comfortably and has a charging port type 2. Its battery efficiency is rated at 186 Wh/km, ensuring optimal energy usage. The real range of the i4 M50 is around 435 km, making it a practical choice for daily commuting. With a starting price of 77,875, the BMW i4 M50 is a premium electric sedan that combines speed, range, and luxury.
The BMW i4 M50 is a high-performance electric sedan that offers impressive performance and efficiency. With a 0-100km/h acceleration time of 3.9 seconds, it delivers quick acceleration that rivals many sports cars. Its top speed reaches 225 km/h, providing an exhilarating driving experience. The i4 M50's battery efficiency, rated at 186 wh/km, ensures a long driving range on a single charge.
This model, released in November 2021, boasts a real range of 435 km, making it suitable for both daily commuting and longer trips. The spacious interior, with seating for five people, offers a comfortable and luxurious ride. The i4 M50's body is designed as a sleek sedan, combining elegance and aerodynamics.
In terms of specifications, the BMW i4 M50 comes with a battery size of 83.9 kWh, providing ample power and range. Its model range can vary between 315 and 620 km, depending on driving conditions and battery usage. The price of the i4 M50 starts at $77,875, making it a competitive option in the luxury electric car market.
Overall, the BMW i4 M50 offers a compelling package for those looking for a high-performance electric sedan. With its impressive acceleration, long driving range, and luxurious features, it provides a great driving experience without compromising on efficiency.
The BMW i4 M50 is an electric sedan model that falls within the model range of 315 - 620 km for its real range. It features a charging port of type 2 and has a battery size of 83.9 kWh. The BMW i4 M50 has received positive reviews, with its top speed reaching 225 km/h and its acceleration from 0-100 km/h in just 3.9 seconds. This model offers seating for 5 people and has a body type of a sedan. The BMW i4 M50 was released in November 2021 and is available for purchase. Its lowest price starts at 77,875. One of the important factors to consider when it comes to tax credit eligibility for electric vehicles is the battery size, which in the case of the BMW i4 M50 is significant. However, it's important to note that tax credit availability and eligibility criteria vary by country, state, and region. Therefore, it is recommended to consult with local authorities or financial advisors to determine if the BMW i4 M50 qualifies for tax credit in a specific area.


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All Your Family Needs is to Go to Big Bend National Park
Are you on vacation right now? Are you in Texas? Then why not go to the Big Bend National Park? You could find it southwest of the state just near the borders of Mexico. The park is practically open all year, along with some beautiful views and landscapes that could really entice the inner wanderlust in you. Hope that the small amount of info given could possibly make you eager in going to this wondrous place.
There are miles of trails and adventures provided just for you. You could either hike with your friends or family, do biking expenditures, or even ride on a horse to really experience the ambiance of the place. If land is not for you, then there is also a river just near the mainland where you could do some water explorations with your family and friends. There are countless water activities and these include kayaking, rafting, and even canoeing to various parts of the river.
The park is practically a desert, where mountains almost act as an island within the place. There is also a high point which could be found somewhere within the park. Once you get to that point, you would really see the marvelous wonders that this planet could offer in a timeline. Want to take a break? Then just chill under the shade of the trees that the park has provided, and just immerse yourself to the wonders of what nature has done. The park, in fact, has a mountain trail that would eventually tire you out.
Discovering The Truth About Resources
Are you the type who likes to camp? Then, this park is also for you. The park itself has three campgrounds wherein you and your family could spend the night and enjoy some marshmallows. If you want to go primal, then there are also options. Primitive campgrounds could be found just near the dirt roads of the park. Primitive campsites like these may not offer amenities provided in developed campgrounds, but they sure do deliver some extravagant sceneries within the area. If you decided to just camp in the mountains, then you could do exactly that by camping on provided open spaces within the area. That makes the park an all-around camping site for all the travel enthusiasts out there.
The Best Advice on Camping I’ve found
So it is no surprise that this park is labeled as one of the most beautiful and interesting sites within the country. It is a good idea for people out there to have this site as one of their bucket list marks. The article in fact gave you all the needed juice to motivate that spark in you!


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By Christine Dzidrums
GymnStars Volume 4
At just 14 years old, gymnast Gabby Douglas left behind her close-knit family in Virginia Beach, Virginia, to train under Liang Chow, famed coach of Olympic legend Shawn Johnson. The move to Iowa was not an easy decision for the focused teenager. For many months, she suffered serious bouts of homesickness. Still, the girl with the golden smile believed her sacrifice would someday lead her to Olympic gold.
A children’s biography and Moonbeam Children’s Book Award Winner, Gabby Douglas: Golden Smile, Golden Triumph will grab readers as they experience the thrilling path the popular gymnast from the Fierce Five took on her way to becoming Olympic Champion and America’s Sweetheart.

domain: library


text:
Looking for previous articles? View the News Archive.
June 02, 2020
Students and parents are concerned about the potential dangers of campus life in the wake of the COVID-19 pandemic. Dining has become an area of particular focus, with consumers expressing a heightened emphasis on food safety and flexible dining options. This brief communication piece explains the steps Sodexo is taking to safeguard the health and well-being of everyone who dines on campus.
March 12, 2020
We take our responsibility for the well-being of the communities we serve seriously and want to share with you the contingency measures we are taking to keep the communities we serve and our employees safe.
October 30, 2019
Culture week at Trinity Western University takes place October 28 - November 1. On October 30th, Sodexo partnered up with the African Caribbean club at Trinity Western University and featured African and Caribbean dishes at the Main Caf. Chef Tanya and Wain had a great time working with the African Caribbean club to develop the recipes and to showcase them to the Trinity Western Community.
October 28, 2019
Reward yourself for being green!

domain: sociology


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It’s a two-fer! First, taste samples of delicious Artigiano Balsamic & Cipolline Onion Cheese from BelGioioso! Second, it’s the Gallucci’s Garlic Cheese dip! See you Saturday, June 29th!
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1973 Bulova Bullhead Chronograph (Ref. 7392) Cal. 11 "Parking Meter"
The vintage Bulova obsession in the watch community is very real and here to stay! The unique and funky watches that Bulova made from the 60s-80s are always a cause for conversation. Ranging from colorful dive watches, chronographs, all the way to eccentric electric watches like the famous Accutron.
The ref. 7392 is a must-have chronograph for any Bulova collector. The chunky and very 70s timepiece is affectionately nicknamed the "parking meter" for its arched 30-minute sub-register located at 12 o'clock which closely resembles what parking meters once looked like. The Bulova ref. 7392 also makes use of the ever-robust Heuer-Buren cal. 11 movement, however, Bulova uniquely turned the movement so the chronograph functions are placed on the top of the case with the winding crown at 6 o'clock, which is a chronograph setup commonly referred to as a "bullhead".
|Bullhead Chronograph "Parking Meter"
|Grey / Blue
|2pc Handmade Leather Strap
The noble case stands proud with a diameter of 43mm and an overall thickness of 14.5mm. The exceptional case is in excellent, potentially unpolished condition with crisp factory finishing present throughout the many surfaces of the uniquely shaped case. The case does exhibit honest signs of use throughout. The mineral glass crystal is free of blemishes or damage. The case retains its original bullhead pump pushers, the crown appears to be an early OEM Bulova-signed replacement. The case back retains its original finishing and features its factory markings in crisp and fully visible condition. The watch will come supplied on a 2pc handmade leather strap.
The slate silver dial with blue detailing is in excellent overall condition, showing some minor spots of age and wear but nothing that detracts from the beauty of the watch. The orange plots remain intact though they are flat and lack dimension, which is commonly seen as the lume plots are usually degraded on these watches when serviced. The original hands have been professionally restored with tritium hand feature a charming tan coloration.
None. The watch is keeping time and functioning perfectly, previous service history is unknown.


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Peshawar police will use drones to monitor polling stations for local body elections. A control room will monitor all cameras in the vicinity.
The Peshawar police have chalked out a plan to deploy over 11,000 personnel for the security of 1,249 polling stations set up in the provincial capital for the Dec 19 local body elections. In a statement issued on Friday, the city police said the Election Commission of Pakistan (ECP) had declared 204 of the capital city’s polling station as most sensitive and 880 others as sensitive. The rest have been declared ‘normal’.
Besides the police, personnel of the Frontier Constabulary will also be deployed at the most sensitive polling stations to ensure peaceful elections. Besides, the police will also deploy drone cameras to monitor polling stations. In addition, the women police, quick response force, bomb disposal unit, canine units and newly-constituted Ababeel Force’s personnel will be deployed to ensure peace in the city on election day.
The police said in preparations for the polls, they had begun strict vigilance at the entry and exit points of the capital city. Besides, they have also increased mobile and rider squad patrolling. According to them, the armored personnel carriers have also been deployed at important government buildings and other sensitive locations. The police have also acquired the services of women staff of civil defense and health department for help maintain the law and order situation on polling day.
The QRF has been tasked with prompt reaction in case of any emergency. Capital City Police Officer Abbas Ahsan directed the police personnel not to let the irrelevant people enter the polling stations. He directed them to maintain queues and ensure physical search of all voters. The CCPO also directed the police personnel to avoid the use of mobile phones during duty.
He asked the people to cooperate with the police and security personnel on that day. Mr Ahsan said the people should alert the nearby police stations after seeing any suspicious person or package. He said the police had decided to deploy the newly-constituted Ababeel Squad for help ensure election security.
The Ababeel Squad personnel will be deployed in the vicinity of polling stations and that they will remain in contact with the central control room and local police authorities. Meanwhile, deputy commissioner of Peshawar Khalid Mahmood on Friday set up a control room to ensure peaceful local body elections in the provincial capital.
In a statement issued here, the DC said the control room would work round the clock during the elections and officials of several government agencies will be deputed there. According to the statement, a meeting took place in his office, which was informed that all preparations for the local body polls had been completed. Also, the security and traffic plans have also been formulated for the purpose, while election material has also been dispatched to the respective returning officers.


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- 1 (32 ounce) bag frozen tater tots
- 2 tablespoons olive oil
- 2 teaspoons garlic powder
- 2 teaspoons chili powder
- 2 teaspoons italian seasoning
- salt and pepper
- nonstick cooking spray
- Preheat oven to 425.
- Empty bag of Tater-Tots into large bowl.
- Drizzle with olive oil and seasonings.
- Toss to coat evenly.
- Spray baking sheet with nonstick cooking spray and spread tater-tots in a single layer.
- Bake for 15-20 minutes.
Photo Credit: acozykitchen.com


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Doing This One Thing Can Lead to Omicron
Think you've been doing everything to keep yourself safe from catching the extremely contagious Omicron variant? Maybe not. In recent days, experts have emphasized that too many Americans have made one particular oversight can lead to an Omicron infection—potentially endangering those who are at risk for severe illness. If you've made it, experts advise you to change that right away. Read on to find out more—and to ensure your health and the health of others, don't miss these Sure Signs COVID is Hurting You—Even After a Negative Test.
Not Getting a Booster Shot Can Lead to Omicron
Health experts have been befuddled and frustrated by the COVID pandemic at a number of turns. One is that, even today, not enough Americans have been fully vaccinated against the coronavirus. As of Feb. 5, that number stands at 64%, even though studies show full vaccination is highly protective against severe illness, hospitalization and death from COVID, even when it comes to the highly contagious Omicron variant. That ranks the U.S. behind 60 other nations.
But more recently, experts are confused by another development: A surprisingly low number of Americans have gotten a booster shot, even though there's evidence the shots are clearly protective against contracting Omicron. The latest numbers as of Feb. 5: Only about half of people in the U.S. who are eligible for a booster have gotten one.
"Why would people who had enough understanding of the risk to go ahead and get a primary series—why we don't have more getting the booster? I don't have an easy explanation for that. That's one of the reasons why we keep trying to put the data out," said Dr. Anthony Fauci, the nation's top infectious-disease expert, last week.
Here's what that data says about how a booster shot can decrease your Omicron risk.
Data: Booster Shots Protect Against Catching Omicron
According to a study published in JAMA Internal Medicine in late January, people who got booster shot had a 66% lower risk of contracting a symptomatic Omicron infection, compared to people who had only received two doses of the vaccine. Other studies showed that booster shots slashed visits to emergency rooms and urgent care centers by up to 80%.
Boosters confer crucial protection to people who are at high risk of severe illness or death, even if they've been fully vaccinated, like those over age 65. Although Omicron causes mild illness in most people, it still poses a serious threat to those groups.
"This booster shortfall is one reason the U.S. has suffered more deaths over the past two months than many other countries," reported David Leonardt in The New York Times this weekend. "The most urgent problem involves the unboosted elderly … But some younger adults are also getting sick as their vaccine immunity wears off."
What Aren't People Getting Boosters?
Leonhardt points out that confusing government messaging about who should get boosters—originally they were only recommended for the elderly and people with certain underlying conditions before being expanded to all adult age groups—may have bred booster hesitancy.
But today, experts are clear. CDC Director Dr. Rochelle Walensky and Dr. Anthony Fauci, the nation's top infectious-disease expert, say every adult should get a booster shot.
In fact, this week, the CDC said that people who are moderately or severely immunocompromised should get a second booster—a fourth dose overall of the Moderna or Pfizer mRNA vaccines—at least three months after their first booster. People who got a Johnson & Johnson vaccine should get an mRNA booster at least 28 days after their initial shot, then a second mRNA booster at least three months after that.
Omicron Super-Contagious, But Not Mild For Everyone
The fact that Omicron was so contagious—many people who had avoided the virus this far contracted Omicron, and others saw vaccinated friends and family contract "breakthrough cases"—may have dampened enthusiasm for boosters.
But experts say data clearly shows that boosters protect against Omicron, from infection to severe illness and death. In fact, some experts say a third shot should no longer be considered a booster but part of the primary vaccine series. "The evidence is clear that it is at least a three-dose vaccine," public health expert Dr. Leana Wen wrote recently in The Washington Post.
"I think we have to redefine fully vaccinated as three doses," Dr. William Schaffner, a CDC vaccine adviser, told CNN on Jan. 27. "I think it's the third dose that really gives you the solid, the very best protection."
How to Stay Safe Out There
Follow the fundamentals and help end this pandemic, no matter where you live—get vaccinated ASAP; if you live in an area with low vaccination rates, wear an N95 face mask, don't travel, social distance, avoid large crowds, don't go indoors with people you're not sheltering with (especially in bars), practice good hand hygiene, and to live your healthiest life, don't miss this life-saving advice I'm a Doctor and Here's the #1 Sign You Have Cancer.

domain: news


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In-situ repair/maintenance is critical for the key industry sectors (e.g. aerospace, nuclear), which require prompt interventions. The paper reports on a tendon driven continuum robotic machine tool with high manoeuvrability in navigating and machining within confined workspaces. The design reveals the main working principles of the robotic machine tool, followed by its calibration method and a new kinematics compensation approach to account for the deformation of the actuation cables that is that the key enabler for its use in machining tasks, which is based on the geometry of the actuation system. Finally, a set of experimental trials were conducted to show its ability to perform in-situ accurate machining operations in a mock-up aerospace scenario.
- Continuum robotic machine tool
- Machine trajectory
- Mechanical design
ASJC Scopus subject areas
- Strategy and Management
- Management Science and Operations Research
- Industrial and Manufacturing Engineering

domain: design


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Mindhunter won the hearts of all crime drama fans with its release in 2017. Created by Joe Penhall and talented David Fincher, the show is a treat for all those who crave the dark psychological crime drama. Charlize Theron, David Fincher, and Joe Penhall are the Executive Producers of the show. The show is based on a true-crime book of the same name written by Mark Olshaker. Set between the 1970s and 1980s, fans get a glimpse of the origin of the infamous Behavioural Science Unit of the FBI.
We follow the brilliant yet quirky Holden Ford (Jonathan Groff), who teaches hostage negotiation at the beginning of the show. However, due to his interest in the psychology of crime, especially serial killers, he is assigned to the FBI’s Behavioral Science Unit. Actor Holt McCallany plays the role of Holden’s partner Bill Tench. Initially, the travel around to teach police departments about serial killers. But, Holden is ambitious, and he wants more. He wants to interview living serial killers where he then meets the illustrious Ed Kemper (Cameron Britton).
Anna Torv, as Wendy Carr, also joins the team to help with the behavioral analysis once the project of interviewing serial killer takes off. She is an invaluable part of the team. The first season ended with Holden having a panic attack after meeting Kemper. He realizes that he is in over his head. The second season he was released in 2019 after a long gap. Set mainly in the 1980s, the second season covered the Atlanta Murders of 1979-81.
What to Expect with ‘Mindhunter Season 3’?
Fans probably devoured the entire second season of 9 episodes in one sitting. The show is addictive and tough to set down because of the overarching screenplay, depth of the characters, and, most of all – the depravity of the human mind.
Fans have been waiting ever since for getting more updates about the show’s future. However, there is some bad news for the fans of the show. In January 2020, Netflix announced that the show had been put on indefinite hold. It is some measure of relief that it has not been officially canceled. Fans will keep hoping for the cast and the crew to get back together to give us more.
The most anticipated elements of the show are the glimpses of the notorious BTK Killer (Sonny Valicenti). The creators have been teasing the fans with the development of the BTK. We were hoping to see Holden cross paths with him soon, but it looks like that even if the show somehow comes back, fans will have to wait for a long time.


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Batman Arkham Knight Riddler guide with Riddles Locations, Riddler Trophy Puzzle Solutions, Destructibles and Bomb Rioters. ... Trophy Puzzles, Bomb Rioters, Destructibles Objects. Batman Arkham Knight - YouTube Batman Arkham Knight Pieces of the Puzzle Trophy- Ridder's Revenge by QNGAMES. 4:14. Play next; Play now; Batman Arkham Knight Terminal Velocity - Predator Mission by QNGAMES. 3:28. Play next; Play now; Batman Arkham Knight Scarecrow nightmare 3 Final Epic Showdown by QNGAMES. 5:47. Riddle solution near Gotham Casino? - Batman: Arkham City ... For Batman: Arkham City on the PlayStation 3, a GameFAQs message board topic titled "Riddle solution near Gotham Casino?".
Batman: The Enemy Within - Gameplay Walkthrough - Episode 4…
Batman: Arkham Origins is a 2013 action-adventure video game developed by WB ... was released in 2014, and a successor video game, Batman: Arkham Knight, was ... The game features collectible objects and puzzles similar to the Riddler .... On the Final Offer, Penguin has added a casino, a fighting pit and a sales floor ... Fifth Riddler trial - Batman: Arkham Knight Game Guide & Walkthrough ... The next Riddler trial takes place in Gotham Casino. Find the garage gate, drive inside and take the elevator into the underground. During this trial, you will have ... Riddler's Revenge - Batman Arkham Knight Wiki Guide - IGN Dec 11, 2016 ... Riddler has set up a series of puzzles for Batman, as well as .... to the Gotham Casino in Northern Miagani Island to find your next puzzle room ... Batman Arkham Knight - Most Wanted Mission Walkthroughs ...
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For Batman: Arkham City on the PlayStation 3, a GameFAQs message board topic titled "Riddle solution near Gotham Casino?".
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Arkham Knight - How to solve Riddler's casino puzzle - YouTube
Batman Arkham Knight Riddler's Revenge Guide - Puzzle Solutions, … Jun 23, 2015 · Batman Arkham Knight Riddler's Revenge most wanted mission guide to help you complete all cave challenges and solve all puzzles. Batman Arkham Knight Riddler's Final Exam Puzzle room 4 solution - … Jul 01, 2015 · Batman Arkham Knight Riddler's Final Exam Puzzle room 4 solution Media Pool. Batman: Arkham Knight - The Perfect Crime ... Batman: Return to Arkham Asylum Ending ... Riddler's Revenge - Batman Arkham Knight Wiki Guide - IGN Dec 11, 2016 · Riddler's Revenge is a side quest and part of Gotham's Most Wanted in Batman: Arkham Knight.. During Chapter 1, after locking up Poison Ivy, Aaron Cash mentions a … Batman Arkham Knight - Most Wanted Mission Walkthroughs - …
That pesky Edward Nigma is back in Batman: Arkham Knight, hiding puzzles all over Gotham for the Caped Crusader to wrap his Bat-brain around. There are an incredible 243 Riddles to overcome, which ... Pieces of the Puzzle Achievement in Batman: Arkham Knight Pieces of the Puzzle Achievement in Batman: Arkham Knight: Obtain a key by completing the second Riddler trial - worth 10 GamerScore


PI extends its large offering of nanometer precise, fast focusing stages with the addition of its new V-308 nanopositioning slide for vertical applications providing 7 mm of Z-travel and 10 nm incremental motion, making it suitable for OEM and research applications in the life science, semiconductor, and material science fields. The novel design combines long travel with unmatched dynamics and precision with 8 m/s2 acceleration and 25-nm bidirectional repeatability.
The closed-loop linear slide uses an optical position sensor with sub nanometer resolution and a voice coil linear motor to allow vertical or horizontal travel up to 7 mm with a velocity up to 200 mm/sec (8 in./sec) for fast accurate scanning. Guided by low-friction cross-roller bearings, this low-profile linear slide delivers long lasting performance in high duty cycle industrial applications. Ease-of-use is built in with a user-adjustable counterbalance, (e.g. for heavy, large NA microscope objective lenses up to 1 kg in vertical applications) and hard stop adjustability to limit the travel range.
For more information, visit www.pi-usa.us/en.


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I’ve been meaning to post for days now, but I couldn’t focus, my thoughts were all over the place. I was thinking about my grandpa in the hospital, in a coma. I was thinking about about how much I wanted to fly down to Miami and visit him, just so he could hear my voice. I wasn’t able to go. As my birthday approached, I wasn’t feeling good about that, but I was optimistic that he’d wake up. He was starting to exhibit signs that he would but some folks around him were already writing him off. I was upset and angry that they weren’t giving Daddy the energy he deserved. I tried to keep my composure and keep my thoughts positive. I’ve always known Daddy to be a positive man, and a fighter who bounces back from anything. I was prepared for the worst, but hoped for the best as I waited to hear an update. My Auntie G and the fam around were very optimistic about Daddy bouncing back as well.
In the wee hours of my birthday morning I texted my twin sister wishing her a Happy Birthday. I also praised us for making it this far. I’m proud of myself for making it through another year in one piece. That is most important to me every year, but I do love birthday cake, and presents. Anybody who knows me, knows that!
In the afternoon, I was informed that my grandfather was no longer with us. I knew there was something off, just by the manner in which my Auntie told me. A decision was made and we were not informed. I knew his passing wasn’t natural, I could feel it. I didn’t ask any questions, it wasn’t the right time for that. It was my birthday and I most definitely did not feel like seeing anyone or celebrating. I was just going to stay in my room, quiet to myself. My fam didn’t want that though, they wanted us to all come together, and celebrate the way Daddy would’ve wanted. I felt as though Daddy’s comforting energy was present. Auntie hugged me saying it’s my day and we will be celebrating with cake. I felt a little better hearing that, I had no excuse to go and hide away. My cousin texted me telling me she’s on her way.
This is a birthday I will never forget. RIP Daddy.
Love and Respect,
Follow me @:https://twitter.com/iamdawnlovely, https://t.co/wfctLWHJ1W


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- Top of page
- Materials and Methods
4-Methylesculetin (4-ME) is a synthetic derivative of coumarin that displays a potent reactive oxygen species (ROS) scavenger and metal chelating agent and therefore has been produced to help reduce the risk of human disease. The main objective of this study was to investigate the in vivo genotoxicity of 4-ME and initially to verify its potential antigenotoxicity on doxorubicin (DXR)-induced DNA damage. Different doses of 4-ME (500, 1000 and 2000 mg kg–1 body weight) were administered by gavage only or with a simultaneous intraperitoneal (i.p.) injection of DXR (80 mg kg–1). The following endpoints were analyzed: DNA damage in peripheral blood, liver, bone marrow, brain and testicle cells according to an alkaline (pH > 13) comet assay and micronucleus induction in bone marrow cells. Cytotoxicity was assessed by scoring polychromatic (PCE) and normochromatic (NCE) erythrocytes (PCE/NCE ratio). No differences were observed between the negative control and the groups treated with a 4-ME dose for any of the endpoints analyzed, indicating that it lacks genotoxic and cytotoxic effects. Moreover, 4-ME demonstrated protective effects against DXR-induced DNA damage at all tested doses and in all analyzed cell types, which ranged from 34.1% to 93.3% in the comet assay and 54.4% to 65.9% in the micronucleus test. Copyright © 2012 John Wiley & Sons, Ltd.
- Top of page
- Materials and Methods
Coumarin is a naturally occurring secondary plant compound that taken together with its derivatives has a wide spectrum of biological activity (Rositca et al., 2002; Flasik et al., 2009), including antitumor (Nofal et al., 2000), anticoagulant (Smitha and Sanjeeva, 2004), anti-inflammatory (Garazd et al., 2007), antifungal (Satyanarayan et al., 2008), anti-HIV (Kotali et al., 2008) and antibacterial agents (Al-Amiery et al., 2012). Coumarins are widely used as pharmaceuticals and optical brighteners (Zabradnik, 1992), dispersing fluorescent and laser dyes (Heravi et al., 2008), and as additives to food, perfumes and cosmetics (Kennedy and Thornes, 1997).
Coumarin belongs to a group of herbs and spice components called ‘active principles’ that, although add to the flavoring effect, also have toxicological relevance. Coumarin is deemed to be hepatoxic and, administered in very high doses in animal experiments over long periods of time, has a carcinogenic effect (Cohen, 1979; EFSA, 2004).
Several previous studies have been conducted to evaluate the genotoxic potential of coumarin, with both positive and negative results reported. In the Ames test using Salmonella typhimurium strains TA98, TA1535, TA1537 and TA1538 with or without metabolic activation, the results were negative (NTP, 1993; Lake, 1999). However, a positive response was reported for strain TA100 with metabolic activation (Stolz and Scott, 1980; Norman and Wood, 1981; NTP, 1993). In Chinese hamster ovary (CHO) cells without the S9 fraction a positive response for inducing sister chromatid exchanges was observed. Chromosomal aberrations were increased in the presence of S9 but not in its absence (NTP, 1993). On the other hand, Sasaki et al. (1987) found no evidence of a sister chromatid exchange or chromosomal aberrations in this same cell line treated with coumarin.
In in vivo genotoxicity tests, no increases in micronuclei were observed in peripheral blood (NTP, 1993) or in bone marrow cells from male mice treated with coumarin (Morris and Ward, 1992). Moreover, this compound did not induce a sex-linked recessive lethal mutation in germ cells from Drosophila melanogaster adults and larvae (NTP, 1993). Api (2001) also observed that coumarin was negative in an in vivo mouse micronucleus assay.
Coumarins exhibits, among other properties, anti-oxidant activity (Farombi and Nwaokeafor, 2005). The structure of coumarins could bind a transition metal ion such as Fe(III), and thus inhibit hydroxyl radical and hydrogen peroxide formation produced by Fenton's reactions. Furthermore, their hydroxyl functions are potent H+ donors for free radical acceptors owing to electron delocalization across the molecule (Sharma et al., 2005). Thus, coumarin derivatives could be potent reactive oxygen species (ROS) scavengers and metal chelating agents. A large number of structurally novel coumarin derivatives have been synthesized to improve this antioxidant activity (Beillerot et al., 2008).
The major metabolic route of coumarin in the rat is by oxidation to form an unstable coumarin 3,4-epoxide intermediate (Born et al., 1997), which decomposes to o-hydroxyphenylacetaldehyde, which is the major metabolite of coumarin formed in rat liver microsomes (Lake et al., 1992). The major identified metabolite of coumarin in the rat in vivo is o-hydroxyphenylacetic acid (Lake, 1996). In the rat, single doses of coumarin produce hepatic necrosis (Lake, 1984), whereas chronic administration at high doses resulted in bile duct lesions and liver tumors (Lake et al., 1994). To our knowledge, there are no data in the literature about the biotransformation of the synthetic coumarin derivative 4-ME, and in spite of the therapeutic potential of the coumarin derivatives, studies on their possible genotoxic or antigenotoxic effects are lacking.
Given that data on the genotoxicity or protective effects of coumarin are partially conflicting and that a number of coumarin derivatives have been synthesized for potential use by humans, further studies must be performed to clarify the genotoxic/antigenotoxic potency of these compounds. The chemical structure of 4-ME is comprised of two hydroxyl groups on the benzene moiety which were more effective in scavenging radicals compared with other coumarin derivatives (Lin et al., 2008). In this context, the present study focuses on the in vivo analysis of the genotoxic potential of 4-methylesculetin (4-ME) for the first time, using a comet assay and a micronucleus test in different cells of mice, as well as an initial analysis of its antigenotoxic effects against oxidative DNA damage caused by doxorubicin, because this anthracycline antibiotic, during its metabolization, generates superoxide radicals which rapidly generate other ROS, such as hydroxyl radical and hydrogen peroxide.
- Top of page
- Materials and Methods
The 4-ME comet assay genotoxicity results are shown in Table 1, where the results for the different doses of 4-ME and DXR positive controls were compared with negative controls (sunflower oil). The cell viability observed in the Trypan blue staining procedure was over 85% in all cases, which confirms the absence of cytotoxicity found by means of the PCE/NCE ratio in the MN test (Table 3). No deaths, morbidity or distinctive clinical signs were observed in the treated animals after 4-ME treatment. As expected, when positive controls were compared with negative controls, we found that DXR induced a significant increase (P < 0.001 or greater) in comet assay DNA migration for all cell types analyzed, indicating the validity of the species selected and the study design to detect genotoxic effects. No significant increase in comet assay DNA migration was found at any of the 4-ME doses or in any of the cells type analyzed. There was no statistical difference in DNA migration between the three tested doses of 4-ME in each cell type. In the few cells that presented DNA damage, it was predominantly minor (class 1) as was also observed in negative controls.
Table 1. DNA migration in the comet assay for assessing the genotoxicity of 4-methylesculetin (4-ME) in different cells of male Swiss mice in vivo [mean ± standard deviation (SD)]
|Treatments and cells analysed||Totald||Comet class||Scores|
| ||0||1||2||3|| |
|Peripheral blood (4-h sample)|
|Control||14.00 ± 4.43||86.00 ± 4.43||12.17 ± 4.62||1.33 ± 0.52||0.50 ± 0.84||16.33 ± 4.55|
|4-ME 500 mg kg–1||20.67 ± 1.63a||79.33 ± 1.63||20.00 ± 2.00a||0.67 ± 1.03||0.00 ± 0.00||21.33 ± 1.86|
|4-ME 1000 mg kg–1||19.00 ± 3.16||81.00 ± 3.16||18.83 ± 3.19||0.17 ± 0.41||0.00 ± 0.00||19.17 ± 3.19|
|4-ME 2000 mg kg–1||12.00 ± 3.58||88.00 ± 3.58||11.67 ± 3.93||0.33 ± 0.52||0.00 ± 0.00||12.33 ± 3.27|
|Doxorubicin 80 mg kg–1||32.50 ± 4.76c||67.50 ± 4.76c||28.00 ± 4.65c||3.17 ± 1.17c||1.33 ± 0.82a||38.33 ± 4.55c|
|Peripheral blood (24-h sample)|
|Control||12.33 ± 3.27||87.67 ± 3.27||11.50 ± 3.56||0.83 ± 0.75||0.00 ± 0.00||13.17 ± 3.13|
|4-ME 500 mg kg–1||20.50 ± 8.71||79.50 ± 8.71||20.00 ± 8.99||0.50 ± 0.55||0.00 ± 0.00||21.00 ± 8.46|
|4-ME 1000 mg kg–1||25.33 ± 5.47a||74.67 ± 5.47a||23.83 ± 4.62a||1.50 ± 1.38||0.00 ± 0.00||26.83 ± 6.49|
|4-ME 2000 mg kg–1||16.83 ± 3.13||83.17 ± 3.13||15.17 ± 3.60||1.50 ± 1.64||0.17 ± 0.41||18.67 ± 3.83|
|Doxorubicin 80 mg kg–1||83.67 ± 9.33c||16.33 ± 9.33c||76.00 ± 5.90c||6.50 ± 4.81c||1.17 ± 0.41c||92.50 ± 14.21c|
|Control||33.17 ± 4.36||66.83 ± 4.36||32.33 ± 4.08||0.83 ± 0.98||0.00 ± 0.00||34.00 ± 4.82|
|4-ME 500 mg kg–1||46.67 ± 9.16a||53.33 ± 9.16||45.67 ± 9.22||1.00 ± 1.10||0.00 ± 0.00||47.67 ± 9.22|
|4-ME 1000 mg kg–1||42.83 ± 7.70||57.17 ± 7.70||41.33 ± 8.07||1.50 ± 2.07||0.00 ± 0.00||44.33 ± 7.89|
|4-ME 2000 mg kg–1||32.00 ± 6.78||68.00 ± 6.78||32.00 ± 6.78||0.00 ± 0.00||0.00 ± 0.00||32.00 ± 6.78|
|Doxorubicin 80 mg kg–1||84.17 ± 6.62c||15.83 ± 6.62c||53.67 ± 11.00a||20.17 ± 6.74c||8.67 ± 11.13a||120.00 ± 26.37c|
|Control||21.67 ± 5.54||78.83 ± 5.54||21.33 ± 5.05||0.33 ± 0.82||0.00 ± 0.00||22.00 ± 6.10|
|4-ME 500 mg kg–1||24.67 ± 7.15||75.33 ± 7.15||24.67 ± 7.15||0.00 ± 0.00||0.00 ± 0.00||24.67 ± 7.15|
|4-ME 1000 mg kg–1||22.00 ± 3.69||78.00 ± 3.69||21.67 ± 3.33||0.33 ± 0.82||0.00 ± 0.00||22.33 ± 4.18|
|4-ME 2000 mg kg–1||29.67 ± 6.50||70.33 ± 6.50||28.83 ± 6.49||0.83 ± 0.75||0.00 ± 0.00||30.50 ± 6.60|
|Doxorubicin 80 mg kg–1||85.00 ± 6.29c||15.00 ± 6.29c||69.00 ± 10.84c||14.17 ± 10.19c||1.83 ± 1.47c||102.83 ± 16.42c|
|Control||54.00 ± 12.03||46.00 ± 12.03||52.83 ± 11.69||1.17 ± 1.17||0.00 ± 0.00||55.17 ± 12.48|
|4-ME 500 mg kg–1||36.67 ± 4.89||63.33 ± 4.89||34.33 ± 5.75||2.33 ± 1.63||0.00 ± 0.00||39.00 ± 4.47|
|4-ME 1000 mg kg–1||40.17 ± 8.23||59.83 ± 8.23||38.17 ± 9.66||2.00 ± 2.10||0.00 ± 0.00||42.17 ± 7.14|
|4-ME 2000 mg kg–1||40.50 ± 15.93||59.50 ± 15.93||39.83 ± 16.49||0.67 ± 1.03||0.00 ± 0.00||41.17 ± 15.43|
|Doxorubicin 80 mg kg–1||82.83 ± 5.98c||17.17 ± 5.98c||57.67 ± 7.76c||22.00 ± 9.98c||3.17 ± 3.06c||111.17 ± 19.14c|
|Control||27.00 ± 6.93||73.00 ± 6.93||24.50 ± 6.63||2.33 ± 2.42||0.17 ± 0.41||29.67 ± 8.43|
|4-ME 500 mg kg–1||27.17 ± 2.04||72.83 ± 2.04||27.17 ± 2.04||0.00 ± 0.00||0.00 ± 0.00||27.17 ± 2.04|
|4-ME 1000 mg kg–1||24.83 ± 2.93||75.17 ± 2.93||23.67 ± 2.66||1.17 ± 1.17||0.00 ± 0.00||26.00 ± 3.58|
|4-ME 2000 mg kg–1||26.50 ± 8.09||73.50 ± 8.09||22.67 ± 8.64||3.50 ± 2.07||0.33 ± 0.52||30.67 ± 8.26|
|Doxorubicin 80 mg kg–1||65.50 ± 5.13c||34.50 ± 5.13c||55.83 ± 10.57c||8.33 ± 4.27c||1.33 ± 2.34||76.50 ± 6.57c|
Table 2 shows the extent of DNA damage in different cells simultaneously exposed to 4-ME and DXR. There was a significant reduction in the extent of DNA damage for all three tested doses and in all analyzed cell types compared with the group treated with DXR alone. DNA damage reduction was high for all doses and cell types, ranging from 93.3% in the bone marrow cells of animals treated with 1000 mg kg–1 of 4-ME to 34.1% in the peripheral blood cells of animals treated with 2000 mg kg–1. The results showed that 4-ME clearly protected against the DNA-damaging agent DXR.
Table 2. DNA migration in the comet assay for assessing the antigenotoxicity of 4-methylesculetin (4-ME) in different cells of male Swiss mice in vivo (mean ± standard deviation (SD)]
|Treatments and cells analyzed||Totald||Comet class||Scores||Reduction % (*)|
|Peripheral blood (4-h sample)|
|4-ME 500 mg kg–1 + DXR 80 mg kg–1||23.33 ± 2.73b||76.67 ± 2.73b||23.00 ± 2.61||0.33 ± 0.52c||0.00 ± 0.00c||23.67 ± 2.94c||66.7|
|4-ME 1000 mg kg–1 + DXR 80 mg kg–1||22.33 ± 5.32b||77.67 ± 5.32c||22.17 ± 5.27||0.17 ± 0.41c||0.00 ± 0.00c||22.50 ± 5.39c||72.0|
|4-ME 2000 mg kg–1 + DXR 80 mg kg–1||30.67 ± 3.27||69.33 ± 3.27||30.50 ± 3.21||0.17 ± 0.41c||0.00 ± 0.00c||30.83 ± 3.37a||34.1|
|Doxorubicin (DXR) 80 mg kg–1||32.50 ± 4.76||67.50 ± 4.76||28.00 ± 4.65||3.17 ± 1.17||1.33 ± 0.82||38.33 ± 4.55||--|
|Peripheral blood (24-h sample)|
|4-ME 500 mg kg–1+ DXR 80 mg kg–1||22.17 ± 6.65c||77.83 ± 6.65c||21.00 ± 6.90c||1.33 ± 1.21b||0.00 ± 0.00c||23.67 ± 6.86c||86.8|
|4-ME 1000 mg kg–1 + DXR 80 mg kg–1||22.00 ± 3.46c||78.00 ± 3.46c||21.50 ± 3.78c||0.50 ± 0.55c||0.00 ± 0.00c||22.50 ± 3.21c||82.8|
|4-ME 2000 mg kg–1 + DXR 80 mg kg–1||33.83 ± 10.19c||66.17 ± 10.19c||33.67 ± 9.87c||0.50 ± 0.84c||0.00 ± 0.00c||34.67 ± 10.71c||72.9|
|Doxorubicin (DXR) 80 mg kg–1||83.67 ± 9.33||16.33 ± 9.33||76.00 ± 5.90||6.50 ± 4.81||1.17 ± 0.41||92.50 ± 14.21||--|
|4-ME 500 mg kg–1+ DXR 80 mg kg–1||67.33 ± 6.80||32.67 ± 6.80||60.17 ± 11.67||6.67 ± 4.72c||0.33 ± 0.82a||74.50 ± 3.89c||52.9|
|4-ME 1000 mg kg–1 + DXR 80 mg kg–1||70.50 ± 6.28||29.50 ± 6.28||59.33 ± 11.15||10.50 ± 9.09a||0.67 ± 0.82a||82.33 ± 12.56b||43.8|
|4-ME 2000 mg kg–1 + DXR 80 mg kg–1||50.50 ± 19.21c||49.50 ± 19.21c||48.83 ± 17.06||1.67 ± 2.25c||0.00 ± 0.00a||52.17 ± 21.39c||78.9|
|Doxorubicin (DXR) 80 mg kg–1||84.17 ± 6.62||15.83 ± 6.62||53.67 ± 11.00||20.17 ± 6.74||8.67 ± 11.13||120.00 ± 26.37||--|
|4-ME 500 mg kg–1+ DXR 80 mg kg–1||32.83 ± 6.08c||67.17 ± 6.08c||30.33 ± 6.50c||2.50 ± 2.07c||0.00 ± 0.00c||35.33 ± 6.35c||84.6|
|4-ME 1000 mg kg–1 + DXR 80 mg kg–1||27.00 ± 6.42c||73.00 ± 6.42c||25.67 ± 7.09c||1.33 ± 1.75c||0.00 ± 0.00c||28.33 ± 6.19c||93.3|
|4-ME 2000 mg kg–1 + DXR 80 mg kg–1||47.67 ± 19.20c||52.33 ± 19.20c||45.67 ± 20.10b||2.00 ± 1.79c||0.00 ± 0.00c||49.67 ± 18.44c||66.6|
|Doxorubicin (DXR) 80 mg kg–1||85.00 ± 6.29||15.00 ± 6.29||69.00 ± 10.84||14.17 ± 10.19||1.83 ± 1.47||102.83 ± 16.42||--|
|4-ME 500 mg kg–1+ DXR 80 mg kg–1||61.17 ± 4.71a||38.83 ± 4.71a||58.67 ± 4.68||2.50 ± 0.84c||0.00 ± 0.00c||63.67 ± 4.89c||84.8|
|4-ME 1000 mg kg–1 + DXR 80 mg kg–1||59.17 ± 13.38b||40.83 ± 13.38b||51.00 ± 9.72||8.17 ± 5.81c||0.00 ± 0.00c||67.33 ± 18.20c||78.3|
|4-ME 2000 mg kg–1 + DXR 80 mg kg–1||62.67 ± 13.22a||37.33 ± 13.22a||59.67 ± 12.82||3.00 ± 1.26c||0.00 ± 0.00c||65.67 ± 13.72c||81.3|
|Doxorubicin (DXR) 80 mg kg–1||82.83 ± 5.98||17.17 ± 5.98||57.67 ± 7.76||22.00 ± 9.98||3.17 ± 3.06||111.17 ± 19.14||--|
|4-ME 500 mg kg–1+ DXR 80 mg kg–1||47.83 ± 4.62||52.17 ± 4.62c||44.83 ± 6.18||3.00 ± 1.79b||0.00 ± 0.00||50.83 ± 3.31c||54.8|
|4-ME 1000 mg kg–1 + DXR 80 mg kg–1||52.00 ± 4.20||48.00 ± 4.20b||48.67 ± 5.79||3.33 ± 1.63b||0.00 ± 0.00||55.33 ± 2.66c||45.2|
|4-ME 2000 mg kg–1 + DXR 80 mg kg–1||29.67 ± 3.88c||70.33 ± 3.88c||26.17 ± 3.76c||3.17 ± 0.75b||0.33 ± 0.52||33.50 ± 4.32c||91.8|
|Doxorubicin (DXR) 80 mg kg–1||65.50 ± 5.13||34.50 ± 5.13||55.83 ± 10.57||8.33 ± 4.27||1.33 ± 2.34||76.50 ± 6.57||--|
The results of experiments designed to assess the clastogenicity of 4-ME in the bone marrow cells of mice are shown in Table 3. As expected, the positive mutagen DXR induced a statistically significant increase in the number of micronucleated polychromatic erythrocytes (MNPCE). However, the clastogenicity test revealed no increase in the mean number of MNPCE at any tested dose. 4-ME did not cause a statistically significant decrease in PCE/NCE ratios. These data indicate that 4-ME had no clastogenic or cytotoxic effects on the bone marrow cells of mice.
Table 3. The number of micronucleated polychromatic erythrocytes (MNPCE) observed in the bone marrow cells of male Swiss mice (M1-6) treated with 4-methylesculetin (4-ME) and respective controls. Two thousand cells were analyzed
|Treatments||Number of MNPCE per Animal||MNPCE (Mean ± SD)||PCE/NCE (Mean ± SD)||Reduction (%) (*)|
|Control (sunflower oil)||1||2||2||1||2||1||1.50 ± 0.55a||1.32 ± 0.12|| |
|4-ME (500 mg kg–1)||1||2||1||1||4||2||1.83 ± 0.83a||1.10 ± 0.04a, b|| |
|4-ME (1000 mg kg–1)||2||3||4||3||2||3||2.83 ± 0.82a||1.27 ± 0.10|| |
|4-ME (2000 mg kg–1)||2||4||1||2||2||2||2.17 ± 0.98a||1.22 ± 0.08|| |
|4-ME (500 mg kg–1) + DXR (80 mg kg–1)||7||5||7||8||6||5||6.33 ± 1.21a, b||1.35 ± 0.08||65.9|
|4-ME (1000 mg kg–1) + DXR (80 mg kg–1)||7||6||7||5||6||7||6.33 ± 0.82a, b||1.20 ± 0.08||65.9|
|4-ME (2000 mg kg–1) + DXR (80 mg kg–1)||7||7||9||6||8||9||7.67 ± 1.21a, b||1.29 ± 0.06||54.4|
|DXR (80 mg kg–1)||16||11||13||15||21||18||15.67 ± 3.56b||1.36 ± 0.09|| |
The frequencies of MNPCEs in bone marrow cells of Swiss mice treated with different doses of 4-ME plus DXR are also presented in Table 3. The oral administration of different doses of 4-ME concomitantly with an injection of DXR led to a significant reduction in the frequency of MNPCEs compared with animals treated only with DXR. This reduction ranged from 65.9% to 54.4% in the micronucleus test. A gradual increase in the 4-ME concentration did not result in a proportional decrease in DXR-induced clastogenicity, indicating the lack of a dose-response relationship.
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The alkaline comet assay (pH > 13.0) detects primary DNA damage such as single and double-strand breaks, alkali-labile sites (apurinic/apyrimidinic sites) or errors in the sugar molecule (Collins et al., 2008). This assay is widely used in in vivo experiments to test the genotoxicity of new chemicals (Brendler-Schwaab et al., 2005; Collins et al., 2008). The damage is thus detected before the action of the DNA repair system, which repairs it in an even shorter time than is necessary to fix a mutation. Furthermore, the DNA lesion can be measured in the absence of mitotic activity. On the other hand, for a better evaluation of the genotoxic potential of any compound, the concomitant use of a widely-accepted complementary test system such as the micronucleus test is necessary (Krishna and Hayashi, 2000). In this test, the cells have already gone through at least one cellular cycle and the repair system has already been activated.
Hematopoietic mouse cells are generally used to test the genotoxicity of compounds investigated in in vivo assays with the micronucleus test (Krishna and Hayashi, 2000). This means that little information is available about the test substance's genotoxicity in other organs. Additionally, organ-specific genotoxicity closely parallels cell-specific carcinogenicity (Tsuda et al., 2000). In an effort to improve this situation, the present study analyzed the genotoxic effects of 4-ME in the cells of five different organs, including somatic metabolizing and non-metabolizing cells, and germ cells. Cell viability in each of the analyzed cell types was over 90% (data not shown). The negative control group showed different natural endogenous genotoxicity thresholds; the lowest genotoxicity scores were observed in peripheral blood leukocytes and the highest were in the brain cells. On the other hand, the use of the damage-inducing agent DXR led to a clear increase (P < 0.001) in genotoxicity in each type of cell, indicating the validity of both the species selected and the study design for detecting genotoxic effects.
The genotoxicity data from the comet assay showed that 4-ME, in the doses administered via gavage in mice, did not promote a significant increase in damage scores compared with negative controls for any of the cell types evaluated. Similarly, 4-ME did not promote a significant increase in MNPCE frequency. These results indicate that 4-ME had neither genotoxic nor clastogenic effects on the different cells analyzed. No other study has investigated the genotoxic potential of 4-ME. On the other hand, other in vivo genotoxicity tests evaluating coumarin, the natural precursor of 4-ME, have demonstrated that it does not increase micronuclei frequencies in either bone marrow cells from ICR mice (Morris and Ward, 1992) or the peripheral blood of male or female B6C3F1 mice (NTP, 1993). The same was observed in the bone marrow cells of Swiss mice (Api, 2001).
DXR is a potent chemotherapeutic agent, often used in the treatment of solid tumors, especially for breast and ovarian cancer, but its therapeutic use is limited by its cardiotoxicity. DXR-induced cardiomyopathy includes the formation of oxygen-free radicals (Takemura and Fujiwara, 2007). The semiquinone form, produced by the reduction of DXR by several endogenous enzymes, generates superoxide radicals that rapidly generate other reactive oxygen species, such as hydroxyl and hydrogen peroxide radicals, which can induce apoptosis in cardiomyocytes (Menna et al., 2007). Thus, it is important to test strategies for decreasing the amount of ROS without affecting therapeutic efficiency in order to reduce the cardiac toxicity of this agent.
In the present study's antigenotoxicity tests, 4-ME appeared as an important inhibitor of DXR-induced DNA damage. The comet assay revealed that 4-ME reduced damage up to 93.3% in the bone marrow cell samples of mice treated with 1000 mg kg–1 4-ME simultaneously with 80 mg kg–1 DXR. The micronucleus test in bone marrow cells demonstrated that 4-ME caused a reduction in MNPCE frequency of up to 65.9% in doses of 500 and 1000 mg kg–1.
The literature cites protective effects of coumarin and its derivatives such as 4-ME. Beillerot et al. (2008) studied a wide variety of coumarin derivatives in cancer cells (MCF7) and observed that 4-ME had an antioxidant effect on DXR-induced oxidative damage without affecting the cytotoxic efficacy of this anthracycline. They also pointed out the importance of evaluating these effects in healthy cells. Lin et al. (2008) evaluated the antioxidant activity of coumarin compounds, including 4-ME, in neuroblastoma cells, and observed that these drugs had high antioxidant activity, inhibiting xanthine oxidase and reducing DPPH radicals (1,1-diphenyl-2-picrylhydrazyl hydrate). These and other free radicals such as ROS can interact directly with DNA molecules, resulting in genotoxic damage to cells (Ribeiro et al., 2005). We suggest, therefore, that the antigenotoxic and anticlastogenic activities of 4-ME observed in the present study may have been as a result of the antioxidant activity in this compound that, by diminishing the formation of free radicals, impedes oxidative genetic damage. The hypothesis outlined in this study is supported by the studies of Hiramoto et al. (1996), who reported that esculetin also scavenges hydroxyl radicals, and Beillerot et al. (2008), who reported that 4-ME was able to reduce the oxidative stress induced by DXR in the cancerous MCF7 cells without affecting its therapeutic efficacy. However, further studies are necessary to test if the chemoprevenction of 4-ME against DXR is exclusively by antioxidant effects, once that DXR also cause mutagenicity acting as a topoisomerase II inhibitor and is able to intercalate between base pairs of the DNA affecting DNA replication and RNA synthesis (Ferguson and Pearson, 1996), and also to verify if the antigenotoxic effects of the 4-ME may result in a lesser efficacy of the DXR against the target tumors.
In conclusion, the results obtained in this study showed that 4-ME administered by gavage was not genotoxic in mice peripheral blood leukocytes, liver, bone marrow, brain or testicle cells according to the comet assay or in bone marrow cells according to the micronucleus test. In addition, 4-ME was also observed to play a role in preventing chemically induced DNA and chromosome damage (breakage and loss) in vivo by the antitumor agent DXR. Further in vivo and in vitro studies are necessary to better characterize the protective role of this compound and to explore its therapeutic relevance as antioxidant and as an adjuvant in DXR treatments for humans.

domain: chemistry


text: Bou Regreg River By Jan Hoffmann11 September 2012 A river tour after teaching at the UNCTAD P166 course in Rabat, Morocco. Share this:LinkedInTwitterFacebookEmailPrintMoreRedditTumblrPinterestPocketTelegramWhatsAppLike this:Like Loading... Categories: Africa, Nature, Photos, Seaports Related Articles Maseru Bridge By Jan Hoffmann4 December 2019 Ulaanbaatar – city, people and logistics By Jan Hoffmann31 October 2019 The port of Cartagena By Jan Hoffmann18 September 2019 ( 1 ) Leave a Reply Cancel reply Enter your comment here... Fill in your details below or click an icon to log in: Email (Address never made public) Name Website You are commenting using your WordPress.com account. ( Log Out / Change ) You are commenting using your Google account. ( Log Out / Change ) You are commenting using your Twitter account. ( Log Out / Change ) You are commenting using your Facebook account. ( Log Out / Change ) Cancel Connecting to %s Notify me of new comments via email. Notify me of new posts via email.


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Henry Mitchell wrote for the Washington Post from the early 1970s to 1991. He was best known for his gardening columns, some of which have been gathered in two beloved books, The Essential Earthman and One Man s Garden. In addition to his gardening columns, Mr. Mitchell also wrote feature stories and for years had a general interest column that appeared on Fridays under the title Any Day. This book collects the most enduring of those brilliant columns. Henry Mitchell was a bit of a curmudgeon. He had an eye for cant and an even sharper eye for the deeper truths of reality. Never pompous, his columns were frequently hilarious. He could make you cry, he could make you weep and he could catch you up in the midst of a busy, confusing day and make you pause and reflect: Hey, look at this! He will make you feel good about being a flawed human, and he will even make you think that mortality isn t so bad.
Readers who have enjoyed The Essential Earthman and One Man s Garden will thrill to discover their favorite author s additional accomplishments as they are represented in this lovely book. The illustrations are by Susan Davis, a gifted Maryland artist whose work accompanied many of Henry s columns during the 1980s and 1990s.
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ichelin-starred chefs today led calls for a “minister for hospitality” to be appointed by Boris Johnson amid fears that the restaurant, pubs and hotels sector is facing another disastrous year of slumping revenues.
It comes ahead of a debate in the Commons this afternoon on the so-called #SeatAtTheTable campaign.
Hospitality sector leaders have grown increasingly frustrated at what they see as government indifference to the plight of Britain’s third-biggest employer, which has been forcibly shut down for more than virtually any other sector through the pandemic.
Hartnett said: “Hospitality is a major economic and social force and we need proper representation in government to fight our corner.
“It’s wrong that we don’t have our own minister given the size of hospitality and how important it is in providing jobs.”
Her plea came as a report forecast that hospitality will take another heavy financial hit this year with revenues likely to be down £30 billion, or around 30 per cent, on 2019. That comes after a £47 billion hit in 2020.
The FutureFoodservice report predicts that sales will regain 93 per cent of their pre-pandemic levels in 2022 and warns that cumulative shortfall from 2020-2025 will top £130 billion.

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Heat olive oil in a large skillet over medium high heat. Add the scallions and sauté for a few minutes. Add the diced radishes to the pan and cook for another 7 to 10 minutes, or until the radishes are tender and start to lose a little bit of color.
Transfer the rinsed black beans to the pan and cook for another few minutes, or until they are warmed through.
While everything is cooking, prepare the avocado crema by combining the avocado flesh, cilantro leaves, lime juice, garlic, sea salt, and olive oil in a food processor or high speed blender. Blend until smooth, about one minute. You may need to add an additional drizzle of olive oil to promote blending. Taste and add more seasonings as desired.
Warm the corn tortillas on a griddle or in a skillet over medium heat just before serving.
Add a large spoonful of the radish and black bean filling to each corn tortilla. Top with avocado crema to taste, and serve with fresh lime wedges. Enjoy!


text:
Rick Cacini, founder and curator of the Yukon Veteran’s Museum, visited the Jan. 17 City Council meeting to present the City of Yukon with a “token of the veterans’ appreciation.”
“The City Council and its staff has done wonders for its citizens. I’m here to present just a token for the support all of you have given us and the support you have extended to all of the veterans of this community,” Cacini started out. “So at this time I would like to award a city just a token.”
The plaque reads:
“In recognition of veterans’ support of the veterans of our community, in helping sustain the Veteran’s Museum of Yukon so that it may be a pillar of our community and carry the America tradition of our history to the future. Our deepest thank you—all veterans.”
Mayor John Alberts responded by thanking Cacini and acknowledging all the work he’s done for the Veteran’s Museum.
“It is quite an honor to have this and thank you for your persistence,” Alberts said.
After searching for three years for a permanent home for the Yukon Veteran’s Museum, the City of Yukon helped the Veteran’s Museum relocate to its new location at 1020 W. Main St.
The previous location of the museum caused multiple problems for veterans, including it being housed on the top floor. Cacini said people would carry wheelchairs, with the veterans in them, up the stairs on multiple occasions so they could enjoy the museum. Cacini said he also had to worry about the condition of the building.
“We’ve been asking and begging the city for three years because the roof was falling in on us and we were getting our backs broken because we were carrying up the guys up the stairs to see the place,” Cacini said. “Needless to say, when the city passed that they’re going to take care of us—amen to that—that meant they all understand this museum is not the ‘Rick Cacini Museum,’ it’s the Yukon Veteran’s Museum. It belongs to you people, the citizens of Yukon.
“With [the city’s] help, we have done some great things there.”
Cacini is still working on multiple areas of the museum and adding more donated items. He also said they’re looking at putting a vehicle out front so people would see it.
“Naturally when you see something that big, that’ll draw attention,” Cacini said. “It’s all really coming along and I’m really happy it’s coming along.”
He added that more people are coming to the museum now than ever, and he’s been in talk with Yukon Public Schools Superintendent Dr. Jason Simeroth about bringing in history classes to learn more about the wars.
“Right now we just wanted to thank the city with a token of our appreciation. All the veterans voted on it and we didn’t use museum funds for it, we all pitched in as veterans,” Cacini said.


Keyence’s LR-T series of reflective laser sensors utilize Time of Flight detection and comes with a custom integrated circuit, which provides a sampling rate of approximately 8GHz. The sensors feature a detection distance of 0.06 to 5m (0.02 to 16.4’), a 660 nm red laser light source, an IP 65/IP67 enclosure (Depending on the model), an operating temperature range of -20°C to 55°C (-4°F to 131°F), and an adjustable angle mounting bracket. LR-T laser sensors are suitable for use in general conveyor systems, robotics, automated warehousing, welding cells, transfer presses, metal assembly, and other factory automation applications.
To Learn More:
Headquarters: Elmwood Park, NJ, USA
Product: LR-T Time of Flight laser sensors
Key Features: Detection distance of 0.06 to 5m (0.02 to 16.4’) 660 nm red laser light source, IP 65/IP67 enclosure, operating temperature range of -20°C to 55°C (-4°F to 131°F).
What Keyence says:
View more information on the LR-T sensors.
View More Products| Locate a vendor or system integrator | Receive e-mail updates
Share new products that you think are particularly interesting or helpful by contacting James Carroll, Senior Web Editor, Vision Systems Design.


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Tricia Fountain is a Florabundance customer and talented designer extraordinaire. Although Tricia’s talents are versatile specializing in numerous design styles; our favorite is her romantic garden style for weddings.
Large clusters clumped together for an almost shabby chic look using bold or monochromatic themes is Tricia’s custom signature design. Handling small to large affairs, Tricia uses Florabundance cut flowers for that just “picked” look.
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In Year One we have been learning about seasonal changes in Autumn and creating artwork to represent this. We collected fallen leaves and used them to create a collaged tree trunk, and then we made our own handprint leaves.
Welcome to our year 1 blog. Follow us throughout the year to see all of the things we get up to in class. We will be uploading photos, videos and even recordings of the children explaining what they have been learning. Please feel free to comment as it will be greatly appreciated by staff and the children alike.


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