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Marie Lu’s novel Warcross follows the story of Emika Chen, a teenage hacker that lives in the not too distant future. Lu uses an idea similar to virtual reality to create a high tech game called Warcross. When Emika hacks the game and coincidently ends up in the middle of the championships for Warcross, her life changes drastically. She goes from a poor bounty hunter, living in a cramped apartment, to a praised and well-paid gamer.
There is a catch, though, the maker of the games has her competing for the sole reason of hunting down a different hacker that may pose a threat. Emika is thrown into a world of luxury and competition that comes with higher stakes than she originally thought.
The first thing I have to say about this book is how I could notice how much fun Marie Lu had writing it. She used to work in video games, and she brought her knowledge and passion for it into this book. The last series she wrote was very different from Warcross in that is was fantasy instead of science fiction. Her first series was science fiction as well, so you can see where she heart really lies.
Just a couple weeks ago, I got the chance to meet her at a signing for her newest book, Batman: Nightwalker. When I told her how much I loved Warcross, she was touched. She continued with how much this book really meant to her. I think she got to show her true colors with this story.
In my opinion, what makes this story so special is the uniqueness. Compared to many other young adult science fiction novels, it is very different. There are not any failed utopias or apocalyptic storylines in this book. Emika is not your typical protagonist, but instead, she is a smart rainbow-haired girl, who truly shows her strengths throughout the book.
Despite the term “young adult”, this book could be a favorite for many. Adults and teenagers alike would enjoy this book. Warcross has a little bit of everything. It has romance, comedy, high stakes and mystery. It is another reason why I found the book so amazing.
From the first page of Warcross, I was entranced. I loved the setting of the whole story. In the beginning, Emika lived in New York City, quite different from the present one however. The technology Lu describes adds to the wonder and the excitement in every page. The technological ideas come from what she wishes could be real. Now readers of the novel will wish them to be real too.
Another important aspect Lu includes in her story is diversity. The characters in the novel all have characteristics that are important to have in a young adult novel. Lu is able to show a realistic story with all kinds of people.


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Hypertension and intracerebral hemorrhage recurrence among white, black, and Hispanic individuals.
OBJECTIVE: To clarify whether recurrence risk for intracerebral hemorrhage (ICH) is higher among black and Hispanic individuals and whether this disparity is attributable to differences in blood pressure (BP) measurements and their variability. METHODS: We analyzed data from survivors of primary ICH enrolled in 2 separate studies: (1) the longitudinal study conducted at Massachusetts General Hospital (n = 759), and (2) the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) study (n = 1,532). Participants underwent structured interview at enrollment (including self-report of race/ethnicity) and were followed longitudinally via phone calls and review of medical records. We captured systolic BP (SBP) and diastolic BP measurements, and quantified variability as SBP and diastolic BP variation coefficients. We used multivariable (Cox regression) survival analysis to identify risk factors for ICH recurrence. RESULTS: We followed 2,291 ICH survivors (1,121 white, 529 black, 605 Hispanic, and 36 of other race/ethnicity). Both black and Hispanic patients displayed higher SBP during follow-up (p < 0.05). Black participants also displayed greater SBP variability during follow-up (p = 0.032). In univariable analyses, black and Hispanic patients were at higher ICH recurrence risk (p < 0.05). After adjusting for BP measurements and their variability, both Hispanic (hazard ratio = 1.51, 95% confidence interval 1.14-2.00, p = 0.004) and black (hazard ratio = 1.98, 95% confidence interval 1.36-2.86, p < 0.001) patients remained at higher risk of ICH recurrence. CONCLUSION: Black and Hispanic patients are at higher risk of ICH recurrence; hypertension severity (average BP and its variability) does not fully account for this finding. Additional studies will be required to further elucidate determinants for this health disparity.
Rodriguez-Torres, A; Murphy, M; Kourkoulis, C; Schwab, K; Ayres, AM; Moomaw, CJ; Young Kwon, S; Berthaud, JV; Gurol, ME; Greenberg, SM; Viswanathan, A; Anderson, CD; Flaherty, M; James, ML; Birnbaum, L; Yong Sung, G; Parikh, G; Boehme, AK; Mayson, D; Sheth, KN; Kidwell, C; Koch, S; Frankel, M; Langefeld, CD; Testai, FD; Woo, D; Rosand, J; Biffi, A
Volume / Issue
Start / End Page
Pubmed Central ID
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)

domain: medical


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Latest Weather Blog
Volunteers needed for Attic Trash and Treasure Sale; in memory of Kevin Minor, Sylvia's Toys volunteer
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Masked man went on shooting spree in Livingston Parish
EBR school district bringing back random K9 searches
Mysterious phone call to Nathan Millard's family raises new questions about his...
City-parish leaders announce funeral fund, peace walk honoring slain 11-year-old
Channel 2's Best Bet$: Sweet 16

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text: C-13 NMR spectra of labeled [1-C-13]- and [2-C-13]ascorbic acid were seen to contain resonances arising from the intra-and extracellular populations in suspensions of human erythrocytes; i.e., they displayed the "split-peak" phenomenon. This new observation enabled the ready determination of the location, whether inside or outside cells, of the redox reactions in which the vitamin C was involved and to monitor the transport of the compounds into and out of the cells. Thus, the membrane permeability of ascorbic acid and the apparent V-max and K-M for the reduction of dehydroascorbic acid were determined in a noninvasive manner. In contrast to other work, evidence was found of a transporter of dehydroascorbic acid which is different from the glucose transporter, This transport system also appeared to be involved in the simultaneous reduction of dehydroascorbic acid on its passage into the cells. A second reduction process appeared to occur extracellularly, by the passage of reducing equivalents through the plasma membrane, as occurs with the reduction of ferricyanide. Evidence is presented that the processes of vitamin C recycling rely on different cellular sources of reducing equivalents. Whereas the transport and reduction via the membrane appeared to be dependent on glycolysis (NADH), the reduction of intracellular dehydroascorbic acid, formed in the process of transmembrane electron transfer or by transport from the outside of the cell, is currently thought to depend on NADPH.

domain: chemistry


The killer smiled, supremely confident in his ability to remain unnoticed. He perched motionless on the edge of his seat, carefully sizing up his next victim.
She sat at the bar sipping a White Russian, her sparkling blue eyes glued to the TV, oblivious. News of the vice president’s recent assassination played in a constant loop on the screen. She was strikingly beautiful, with platinum blonde hair that spilled over her shoulders and radiated a delicate sheen. Cherry-red lipstick adorned her full, pouting lips, and her smooth, peach-colored skin glowed with vitality. Her red cocktail dress clung to her in all the right places, and she showed cleavage that Pamela Anderson would have been proud of. Her long, shapely legs were crossed at the knee, a pair of crimson stilettos completing her outfit. He judged her age to be no more than twenty-six, and she was the most fascinating woman he had ever seen.
Blue Oyster Cult’s “Don’t Fear the Reaper” erupted from the dance floor as the live band kicked into gear. A banner spanning the front of the stage read Oldies Night with 4 A.M. A waitress glided by, nodding at his empty shot glass. He shook his head, his sights set on something far more intoxicating.
He leaned back in his chair, his hands trembling as they always did when he was on the hunt. In one rapid motion he stood up and began weaving in and out of the writhing bodies on the dance floor, making his way to the bar. Dazzling green, yellow, and electric blue strobe lights gyrated around him.
Thoughts of his first kill invaded his mind: a college girl, no more than nineteen. He’d attacked her as she was leaving the laundromat of the apartment complex, burdened with a late-night wash load. He remembered the regular pounding noise her fragile, doll-like body made as it tumbled around in the dryer after he’d finished with her. It had gotten easier after the first time, and nowadays he was master of the hunt on the Washington, DC nightclub scene.
He took his place at the bar a couple of stools down from the blonde and pretended to be interested in watching the TV, where Rhonda Hennon was still gabbing about the assassination:
“…Reports continue to flood in regarding the death of the vice president three days ago. The White House isn’t releasing any details on the slayings as of yet, but we will be keeping you informed of the latest breaking developments…”
He caught the blonde woman giving him short, furtive glances in his peripheral vision.
“It’s a damn shame about Sydney O’Shell, isn’t it?” He turned his head towards her. “I mean, what with her being the first woman vice president.”
The news on the street was that someone or something had breezed right through the security and communication equipment of the Naval Observatory and killed Mrs. O’Shell in the Victorian house located on the grounds. To date, no clear leads had been made public.
“It is.” She swiveled toward him, noticing the deep crows’ feet beneath his eyes, the unhealthy pallor of his skin. She returned her gaze to the screen. The fragrance of Elizabeth Taylor’s Obsession perfume drifted over to him.
“My name’s Bill.”
“You can call me Cassie.”
What a pretty name. I can see it carved into your breasts, Cassie.
The band dropped tempo and performed a rendition of Foreigner’s “Waiting for a Girl Like You.” Bill gestured toward the dance floor. “Care to dance?”
Cassie took his hand, looking every bit the ravishing belle of the ball as he led her onto the dance floor. Hugging him close, she scanned his eyes, seemingly mesmerized by his overly large black pupils. It was like peering down a deep, dark well. She buried her cheek in his shoulder, breathing in the tingling pine, sandalwood, and bergamot of his cologne. There was another underlying smell about him; something decidedly earthen, but if Cassie noticed it, she made no comment.
They swayed around the dance floor, multicolored spotlights swirling around them and the other couples taking advantage of the chance for a little intimacy. She placed her delicate arms around his neck, clasping her hands together. Tilting her head upwards, she teasingly brushed his lips with hers, then closed her eyes and kissed him passionately. A fleeting thought crossed her mind: Chilly. Like kissing cow’s liver.
“You’re cold.” Cassie snuggled into his shoulder as they breezed around the room.
A quick glance at his watch told Bill it was three forty a.m. He didn’t have much time. The lead singer’s voice echoed from the speakers, announcing the final song of the night. Drunken revelers rushed onto the dance floor as the band tore into Drivin’ and Cryin’s “Fly Me Courageous.”
“You’re not wearing any panties.”
“But I am wearing panties. They’re also red.” Cassie giggled, and slapped Bill’s shoulder.
“My mistake. I thought we were already at my place. My watch is thirty minutes fast.” Bill smiled at her, and then led her toward the back door. A group of young men sitting near the illuminated green exit sign ogled Cassie as she strode by.
The last remaining red and yellow leaves of fall spun in tiny eddies, dancing along the sidewalk as Bill and Cassie stepped out. A frosty November breeze tousled Cassie’s hair and a bright crescent moon rode high in the sky, outshining the feeble light of the stars surrounding it. The stark blackness of the alleyway beckoned to him. His hands trembled as he fought the urge to drag Cassie screaming into the darkness. I could kill you now.
“Sun will be coming up soon.” Bill palmed the back of her neck. “What would you like to do with what’s left of the evening?”
Cassie nuzzled his ear, her tongue darting out to caress his earlobe. “Let’s go to your place.”
Cassie reclined in her seat, lulled by the Nissan’s exhaust tone. She watched the greenery fly by in the car’s headlights, then shifted her attention to Bill. In the darkness of the car’s interior, his eyes resembled the gaping holes of a human skull.
“How much farther?”
“Oh, about five miles.”
Cassie held Bill’s hand in a soft grip as they cruised on in unbroken silence. Bill finally turned off Highway 6 onto a rock-strewn dirt road. He drove up a steep, winding hill lined by Lobilly pines, stopping in front of a plain country house. Feeble fingers of light from the single porch light did little to dispel the surrounding darkness. Three upper story windows stared at her like blind eyes.
“Now don’t go getting spooked on me. It’s an old house, sure, but it’s been in my family for generations. It’s quite comfy.” Bill opened the front door and stepped in, leading Cassie by the hand. Darkness greeted her. She strained to see, but the only light came from a room to her right. Bill was already halfway there.
Multitudes of lit candles cast their flickering light over the bedroom. Elegant velvet curtains and a four-poster bed dominated the room. Cassie sat down, running her hands over the soft texture of the quilt. “I love four-poster beds.”
Cassie spotted something in an alcove to her left, almost hidden by a drape. She gasped as she realized what it was.
“Why is that in here?”
“Sometimes I like to get kinky, Cassie!” Bill slinked toward her. His pupils were dilated, black as darkest night. His eyes locked on hers, unblinking, the whites turning blood-red. Cassie fell back on the bed in a dead faint, her arm thrown over her head, her hair a tangled mess. Bill sat next to her, eyeing the pulsating blood vessels in her neck. Cassie made a slight mewling sound as Bill leaned over and clamped his mouth on her throat, his incisors piercing her skin, lapping at her flowing blood. He watched her chest rise and fall in a regular rhythm.
I have such plans for you, my dear. Tonight, I may even make you my mate.
Sunlight caressed the window coverings now; dawn was approaching. To all things living, the Sun was a giver of life, a source of comfort, but to Bill it was a voracious monster, waiting to consume him. He settled into the open casket, and the lid slammed shut.
Cassie awoke, shaking herself out of sleep. She scanned her neural web, checking her body for damage. Her lab-grown skin and arteries were still intact. Warm blood pumped from her polyurethane heart, heated and filtered by machinery deep within her infrastructure. Her CPU enabled every available core, utilizing its one hundred MIPS of computational power to analyze the data she’d collected. Her olfactory memory banks sifted through millions of soil samples until it was confirmed: the dirt on Bill’s shoes was a positive match to samples collected on the Naval Observatory grounds.
Body temperature: sixty degrees Fahrenheit. No heartbeat. A DNA profile was compiled by analyzing samples collected from Bill by receptors in Cassie’s tongue and beneath the incisions in her neck. The profile showed lingering traces of Vice President O’Shell’s blood. Cassie closed her eyes and beamed a signal to a satellite somewhere in a high orbit overhead. GPS fixed on her location within a nanosecond. An Apache helicopter was dispatched, and shiny black Lincolns were already rolling toward Cassie’s position.
Bill’s eyelids fluttered open as a sharp object pierced his chest cavity. A dozen men flanked the coffin, brandishing lit torches. Their flames cast glimmering shadows on the bedroom walls. Joe Macadory, head of the elite team, stood sweating over Bill in a white shirt with rolled-up sleeves. Joe held a lengthy ash stake and a square mallet. Bill hissed in defiance as Joe pounded the stake home with measured, deliberate blows. Bill’s world went black.
“Good work, Matt.” Joe clapped him on the back. “Programming Cassie for duty that quickly was a big ask.”
“It was the least I could do for the vice president, sir. I figured Cassie would flush him out if he was still lurking around. She’s our most advanced decoy. She sure fooled him.” Matt gestured toward the coffin with his thumb. “If you don’t mind telling me, sir, how does one get rid of a vampire permanently?”
“Easy,” Joe said. “Cassie?”
Cassie smiled and strolled over to the window. She reached up, grasped one side of the drape, and yanked it free of the rail. Bright sunlight flooded the room. Joe, Matt, and Cassie watched as Bill burst into flames and was reduced to ashes in a matter of seconds. Blue flames licked the air as a secondary fire took hold, and when the flames died down, not even ash remained.
“Good going, sir,” said Les Millian, one of Joe’s snipers. “But tell me. I had my men set up a perimeter around this place. I could’ve put thirty-rounds of ash-tipped bullets through him from the bedroom door if he’d woken up, so why the mallet and ash stake routine?”
Joe leaned back against the door sill, a smile playing across his lips.
“I guess I just like doing things the old-fashioned way.”
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In a speech on Saturday, the former Mayor of New York City and advisor to President Donald J. Trump called for regime change in Iran.
“I think it’s the only way to peace in the Middle East,” said newly-hired Trump lawyer Rudy Giuliani. “It’s more important than an Israeli-Palestinian deal.”
Giuliani was speaking at the Organization of Iranian-American Communities (OAIC), a group that promotes democracy in the Iran. The group supported the protests in the Islamic Republic that occurred late last year.
Once “sanctions [are back], we have a real chance of escalating these protests,” Guiliani continued.
While the OAIC may want the U.S. to “promote democracy” in Iran – which is neocon code for regime change – the Trump-supporting base wants the opposite. In fact, Trump ran for office on a demonstrably anti-war platform.
The State Department has distanced itself from Giuliani’s comments.
“[Giuliani] speaks for himself and not on behalf of the administration on foreign policy,” State Department spokesperson Heather Nauert told AP.
Giuliani’s desire to become Secretary of State prevented him from taking the Attorney General job in the Trump administration, which would have changed the course of the Russia investigation since Giuliani would not have recused himself in the case like Jeff Sessions did.
TRUST THE MAN: Here’s A Growing Map of Deep State Conspirators Who Have Been Fired
President Donald Trump continues to solidify the American people’s position in the federal government.
Former FBI director James Comey is reeling from the FBI’s release of information pertaining to his exit from the Federal Bureau of Investigation.
The forms reveal a mad dash by the Department of Justice in the days after Comey’s spring 2017 firing to retrieve secret information from Comey’s office and to figure out the extent of what Comey was actually doing as FBI director.
Comey signed the Sensitive Compartmented Information Nondisclosure Agreement, which makes it all the more serious that Comey violated sections 2, 3, 4, 5, 8, and 13 by illegally handing over presidential briefing memorandums (page 5 and 6 of FBI release). (READ: Comey Refuses To Deny He Leaked Classified Info)
Comey is not alone in his government unemployment.
An interactive mapping project has sprung up on mindmeister to track Deep State conspirator cells that have been fired in the age of President Donald Trump.
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I want to thank each and every one of you for all the sweet comments about my pincushions being published. I just want you to know that because of you, your encouragement, you cheering me on, your kindess, I have had the confidence to create, to send my artwork to the magazine and now for it to appear inside!!!
Thank you ALL so very much for being my cheerleaders!!

domain: artistic


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Last week, a U.S. District Court judge ruled that the Kentucky Cabinet for Health and Family Services (KCHFS) unfairly dismissed a male employee because he was gay.
In 2009, Milton Stroder was terminated as an adjudicator with the KCHFS for violating policy by sending out personal emails that discussed his partner and used gay-slang terms like “princess” and “queen.”
But as Stroder’s attorney successfully argued, a heterosexual female employee who sent out similarly personal emails was not punished so severely.
“This is unfair and unequal treatment,” [Judge] Heyburn wrote in the nine-page ruling issued last week.
Heyburn noted that the cabinet didn’t take action against Shannon Duncan, who also sent personal emails around the same period, as well as a chain letter to other employees titled “Pampered Chef,” which showed naked men with pots and pans “strategically placed to conceal their genitals.”
Though Duncan and Stroder started the same day and held the same job, Stroder was fired a few days before his probationary period was over—allowing him to be terminated “without a reason or a right to a hearing,” reports the AP.
Duncan, however, wasn’t reprimanded until several days later, by which time she had become a full-time employee and wasn’t subject to termination for such an infraction.
Sure, you could think it was all just a coincidence and that Stroder’s bosses just didn’t like his work. But when KCHFS began enforcing its Internet policy, “friendly homosexual bantering within emails” was targeted disproportionately. Heyburn noted in his decision that, of the first five people reprimanded for violating the email ban, four were gay.
Stroder, who now works as an AIDS/HIV case manager, has until May 15 to either file sanctions or request his job be reinstated. A spokesperson for KCHFS says the agency is considering an appeal.


Gear GlockStore – new G43 Mag Extensions Available Recoil Staff June 16, 2015 Join the Conversation GlockStore is now offering Double Diamond G43 magazine extensions. In addition to help provide a “full hand grip” on the weapon, the magazine extensions will add either +1 or +2 rounds to the existing G43 6 round magazine. For those who want the extension without the extra round (though we're not entirely sure why anyone would prefer this) they offer a +0 configuration that just helps the grip. They're built from aircraft grade billet aluminum there at GlockStore inhouse and are available in black or silver. Check them out here. Explore RECOILweb:Federal Expands 224 Valkyrie Offerings and Joins the Components GameAmerican Made: Radian WeaponsEDCpen: the "ultimate minimalist everyday carry pen"Preview - Production Power - An Inside Look at FN Manufacturing NEXT STEP: Download Your Free Target Pack from RECOILFor years, RECOIL magazine has treated its readers to a full-size (sometimes full color!) shooting target tucked into each big issue. Now we've compiled over 50 of our most popular targets into this one digital PDF download. From handgun drills to AR-15 practice, these 50+ targets have you covered. Print off as many as you like (ammo not included). Get your pack of 50 Print-at-Home targets when you subscribe to the RECOIL email newsletter. We'll send you weekly updates on guns, gear, industry news, and special offers from leading manufacturers - your guide to the firearms lifestyle.You want this. Trust Us.


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Donald Glover On Taking Over Hollywood: “Convince Them That You Speak Old White Man”
Glover shared advice from Billy Dee Williams, and announced that production for Atlanta season two will begin in September in his Hollywood Reporter cover story.
Regarding his ascent in Hollywood, and his desire to shift the focus of film and television towards different perspectives, Glover said, "I know it takes time...and you have to make people feel comfortable. You have to make them understand that you speak their language — that you speak old white man."
Glover will be playing Lando Calrissian in the upcoming Star Wars movie, and he recalled a recent meeting with Billy Dee Williams, who played the character in the original trilogy. “He just let me ramble on and on, and then finally I was like, ‘"So, what do you think?" Glover said. "And he goes, "Yeah, I don’t know about all that. Just be charming.’”
Elsewhere in the interview, Glover announced that production for the second season of Atlanta will begin in September. In another recent interview on BBC Radio 1, he offered an update on his hit series: "I'm not gonna make anything until it's ready. But to be completely honest, it's almost ready. I'm pretty happy with a lot of the things, and I think it's better than the first season."
Read Donald Glover's Hollywood Reporter cover story here.


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Last data update: Nov 22, 2022. (Total: 4101 publications since 2011)
|Query Trace: all>>Patricia J Campbell[CDC Author]|
| Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis.
Patricia J Campbell, Glenn P Morlock, R David Sikes, Tracy L Dalton, Beverly Metchock, Angela M Starks, Delaina P Hooks, Lauren S Cowan, Bonnie B Plikaytis, and James E Posey
Antimicrobial agents and chemotherapy 2011 May 55(5) 2032-41
Similar articles in PubMed DOI:10.1128/AAC.01550-10
| Disparities in capreomycin resistance levels associated with the rrs A1401G mutation in clinical isolates of Mycobacterium tuberculosis.
Analise Z Reeves, Patricia J Campbell, Melisa J Willby, and James E Posey
Antimicrob. Agents Chemother. 2015 Jan 59(1) 444-9
Similar articles in PubMed DOI:10.1128/AAC.04438-14

domain: biology


text:
The new, redesigned Audi Q3 model, the youngest member of the automaker's SUV series, has arrived in the Middle East market.
The model also boasts a number of technical innovations, besides the refreshed de
A consignment of 30,000 live sheep arrived in Bahrain yesterday (May 25) to meet an anticipated surge in demand during Ramadan, which starts next month.
They will be examined and transported to the Bahrain Livestock Company (BLC)
Formula One drivers started arriving in Bahrain yesterday (April 13) ahead of this weekend's Gulf Air Bahrain Grand Prix.
High-profile racers who touched down included defending Formula One World Champion and Mercedes driver L
McLaren Automotive is set to continue rapid expansion in the Middle East and Africa, with the McLaren P1, the first of a new breed of hypercars, due to be delivered to customers in the coming weeks.
The British car manufacturer is
After the partial lifting of EU airspace, the first aircraft landed in Munich and Frankfurt bringing overseas exhibitors and visitors to 'bauma 2010,' one of the world´s leading trade fairs for construction and building materials.

domain: geography


Joe Gibbs said Friday that he was unaware of the bounty program players say then-defensive coordinator Gregg Williams conducted during Gibbs’ second stint as the team’s head coach. Had he known, Gibbs said, he never would have permitted it.
“Just let me say this: I’m not aware of anything like this when I was coaching there,” the Hall of Fame coach said in a phone interview. “I would never ask a player to hurt another player. Never.”
Williams, Gibbs’s top assistant on defense for four seasons, ran a pay-for-big-play system in which players were rewarded for, among other things, knocking out opponents from games.
Five players and one former Washington assistant confirmed that Williams’s bounty program was operated under Gibbs, who said he was surprised by the news.
The information about the bounty system, according to the players and coach, was widely known at Redskins Park. Considering that, Gibbs said he could understand why many would believe the head coach would also know, “but I didn’t,” Gibbs said. “In my life … I wouldn’t ever tell a player to hurt somebody.
“They may say, ‘Well, Joe would know, because everybody else knew.’ But I didn’t know. I’m shocked by this.”
After leading the Redskins to three Super Bowl championships, Gibbs retired from coaching following the 1992 season. Lured back to the franchise by owner Daniel M. Snyder, Gibbs again led the Redskins from 2004-07.
Gibbs hired Williams and gave him full control of the defense. At least initially, Williams apparently established the bounty fund by using money players paid in team fines. Players also contributed to the bounties, the former assistant said.
Gibbs declined to discuss how he administered fines, but a person familiar with his disciplinary approach said Gibbs rarely fined players. Also, Gibbs never rewarded players with cash bonuses, which is a violation of NFL rules, the person with knowledge of the situation said.
For exceptional performances, Gibbs provided players with premium parking at the team’s Ashburn-training complex and recliners to relax in after practice, the person said. If turnovers were committed during practice, players ran laps, and Gibbs often ran with them.
“I’m just not aware of anything like this,” Gibbs said.
More on NFL bounties:


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domain: design


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Management: The issue and act of the episodes of these two shows, Shigofumi’s Episode 3: “Friends”, and Death Parade’s Episode 11 “Memento Mori” and Episode 12 “Suicide Tour,” is, of course, a rather controversial point of discussion in popular and private discourse, and so my intention, with this essay, is to posit Shigofumi’s and Death Parade’s musings on the subject in a thought-provoking way. Additionally, while I may hold a positive opinion overall of this show, this piece in no ways serves as a comprehensive review of the series, but rather an articulation and analysis of an interesting set of ideas brought up.
This piece also references a previous post of Shigofumi I wrote, which can be found here.
I published a little thematic piece on Shigofumi when I started out blogging. The piece is somewhat of a reflection of how far my blogging voice has come since. My writing then was less lengthy than it is now, by a considerable degree. It was more structurally rigid and emotionally reserved. Now, I’ve gotten to the point where I’m more confident saying a whole variety of different things. The Shigofumi piece ended up drawing some debate, and that debate pertained both to how I interpreted the show’s targeted message as well as the acceptability of the targeted message itself. I made no secret that I was supportive of that message.
That message was anti-suicide.
While it tells its a separate story, Death Parade makes the same message. It is critical of the reasoning that has driven many people to kill themselves. I understand that suicide is a sensitive topic for a lot of people, and what I will say will sound like suicide victim blaming. Consequently, I will make pains to clarify what kind of suicide these shows and I are calling out on. However, if the creators behind Shigofumi and Death Parade are willing to make these points unreservedly, then it would behoove me to not hold back.
The scenario illustrated in Episode 3 of Shigofumi, “Friends,” appears incredulous on face value. A kid by the name of Daiki Senkawa jumps off a building and commits suicide. Everyone, distraught, curious, or some synthesis of the two, from news media to his school to friends, are wondering… why. Why? One friend of Daiki’s, Tooru, is particularly troubled by this question. Barring the indignity of not coming to his friends about this at all, he didn’t seem the person you’d think would commit suicide. He didn’t seem to be depressed, nor did he seem to be concealing any symptoms of depression. By all appearances, the kid was a model student and son.
His father was perplexed too, perplexed enough to hold his classmates hostage with a double-barreled shotgun until he could get an answer out of them to alleviate his anxiety. The father insists with the utmost sincerity Daiki wasn’t being abused at home. The next likely place for harassment left, thought the father, must have been school-related.
Was he being bullied at school? Which one of you was responsible? I just want to know. I’m his father after all.
The unique plot device of the show kicks in as the main recurring character, Fumika, effortlessly bursts through desk-barricaded door and points her own firearm at the father before he can stop her momentum in the form of a hand-mail delivery to Tooru.
What she delivered, a shigofumi, is a letter (fumi) delivered from the afterlife (shigo), and what do you know? The letter is from the recently deceased Daiki. Tooru reads it aloud, and Daiki’s words end up clearing all the misunderstanding. Daiki killed himself because he was curious about the experience.
“In it, he wrote that he himself became curious of what it would be like to jump. He stated that while he had no particular reason to die, but he had no particular reason to leave either.
And that’s that.”
Tell that to his terrorized classmates. Tell that to his traumatized father.
But, you know, taking a disinterested step back, you can’t help but feel this is a little too convenient. Barring the supernatural, of course, even if this hostage scenario is something that could plausibly occur in real life, it’s not like it’s probable that it would escalate to the extent it did in this show. Additionally, it’s not like this kid knew it would end up as disastrously as it did, that his father would take up a gun in his son’s name to secure justice, revenge, or some synthesis of the two.
I’d tell these commenters that they’re missing the point. What they’re claiming threatens to undermine any attempt by creators to use the fantastical and surreal to demonstrate the real. I’d also accuse those commenters of lacking imagination, or at least some historical depth. World War I is essentially a potpourri of numerous worse case scenarios, like the one involving death of the Austro-Hungarian Archduke Franz Ferdinand and a sandwich, making up a worst one, a disastrous event on a global scale that lead to the deaths of millions. I’d also challenge this implication that the suicide in question would have been less serious if people weren’t physically injured as a consequence. Malaise can be psychosomatic, after all, but suppose the health of one’s mind and body was dualistic. People still end up emotionally upset, and that make people do destructive things. These commenters, however, seem to imply that that kind of hurt deserves much less merit, if any merit at all.
That kind of hurt has made people kill themselves and kill other people, hurt themselves and hurt other people. Grief can kill, and even when it doesn’t, it hurts. It really hurts, and to put other family and friends into that potential kind of situation means some two-to-three combination of:
1. Being certain that there’s no potential for them to suffer,
2. Being negligent about their potential suffering, and/or
3. Being self-centered.
You can argue that he was being negligent, if not about hostage scenario per se, then at least about the grief he caused his friend, his classmates, and his father. But why was he negligent?
Because he only thought to sate his curiosity.
He thought only about himself.
Daiki was self-centered.
Now, I’m not denying that Daiki’s case isn’t exactly representative for the majority of suicides that have occurred. If not unique, his case is probably rare, and when we discuss suicides in society, we typically discuss them in the context of depressed individuals abruptly taking their own lives.
I’m going to qualify that the suicide I’m going to address are people who possess a relatively decent amount of agency to do independent things other than suicide, and I’m going to exclude cases where euthanasia is concerned. I’m going to talk about individuals with the relative physical and social mobility of people like Daiki. These individuals take their own lives when their depression overwhelms them, when they either endure misery enough that they feel they have nothing and no one left to live for, or feel pained enough that they feel what and who they can live for isn’t worth the trouble. I’ve had another commenter criticize, albeit respectfully, Shigofumi’s message on suicide for being an attack on personal freedom, a defense I personally feel is dubious. People should be able to take their own lives if they feel like it so long as it doesn’t cause direct physical injury to other people. Said people shouldn’t have to cater to the feelings of others. It’s an individual choice, and we should respect it. After all, people are individuals.
The first half of Episode 11 of Death Parade, “Memento Mori,” reveals the circumstances that led Kurokami no Onna, the Black-haired Woman, Chiyuki, to her death.
A person who developed a love for ice skating after her mother read her a children’s book when she was little, her rising career in the sport was cut short when an accident on the rink left one of knees badly injured to the point that could never skate again.
However, what ate at her to the point she slit herself in the bathroom wasn’t that she she couldn’t skate. She realized well enough that there were other in her life that were important, that she could occupy her time with. No, what led her to bleed out from wrists into a pool of bathwater was the fact she was an…
She realized that the friends she made were ones she made through her passion for ice skating. Once she stopped skating, she noticed they weren’t around her like they always were. It’s not like they didn’t necessarily care for her, but the vast share of the time they spent together was correlated to something involving their mutual passions. A vast share of her time was spent distracted on skating.
The time she used to devote herself to skating, she now spent, for the first time, consciously alone. Her friends were off doing some skating-related or not, and in the silence of that solitude, her eyes ended up gazing into the abyss. She felt its chill, and she realized in the whispers the abyss mouthed from its gaping and fathomless mouth something about her that many philosophers had previously inferred about the concept of the…
As individuals, we are fundamentally alone. It was in this smallness, in this existential despair of crushingly Lovecraftian likeness, in this…
…that she took her own life.
And that’s that.
“Except that it’s not.”
Episode 12 of Death Parade “Suicide Tour” has Decim taking Chiyuki on a tour of the consequences of her suicide. She wakes up in the house she grew up in and left behind, tours the kitchen and living space before her mother returned. Chiyuki’s mother can’t see her, nor can Chiyuki touch her, but almost automatically knelt down before an indoor shrine to reflect and pray for her daughter.
And then the mother gasps, shaking over how she could have let her daughter to this to herself. She cries, agonizing couldn’t foresee this as something her precious daughter would do. She wails, anguishing about how she couldn’t understand her.
And with that, Chiyuki gasps, repudiating under her breaking breath her previous personal assertion at the futility of understanding people. She cries. She screams and begs Decim through her sobs to help her make this right and apologize to her mother. Decim almost automatically whips out a solution hearkening to Mayu’s trial by Ginti in the second half of Episode 11.
If you press this button, you can save yourself from your suicide.
All you need to do is let someone take your place in death.
It’s true that perhaps one of your friends and family might be the one chosen, but in a world of 7 billion+ people, that’s highly unlikely.
It’ll most likely be a complete a complete stranger.
And with a great offer like that, coupled with her desperation, she makes for the button in Decim’s hand.
But then, memories of all the past games she helped facilitate where people bared their lives for Chiyuki to see and Decim to judge.
What of the people they left behind? The friends? The family? If I took another person’s life in order to live, wouldn’t I be putting that person’s friends and family into the same kind of pain that I subjected my mother to? The people I saw during these games who struggled so hard and cried so much.
Why am I the only one allowed to get special treatment?
It turns out that “who” Chiyuki was seeing was a “what.” It was a dummy that looked like her mother and acted like her mother based off of Decim’s imagination. Does the fact that Decim imagined this whole ordeal for Chiyuki mean that it was worthless? No, because like the hostage scenario in Shigofumi, what Death Parade was trying to illustrate in this scene was empathy, empathy in the face of callous assertions of personal freedom and maddening bouts of depression.
There’s no guarantee of an afterlife that would allow you to see the future when you commit suicide. Matters of afterlives are matters of faith, but hypothetically speaking (and consequently assuming), if there was no afterlife, then death could be really called the ultimate escape from life and the pain associated with it. There would be no regrets in death because you’re dead and gone.
But while your own life ends, life for everyone else on Earth goes on, and the people left behind might be definitely be feeling regret. They might be feeling remorse. They might be gasping for air, crying scalding tears, and wailing and screaming in terrible grief and self-loathing. Their depression might fall into a despair they can’t get out of. They might do something desperate and hurt themselves and other people physically. But that’s only physically. Emotionally, they might hurt. They might really hurt. And because you’re dead and gone, it’s impossible to perceive this and reply back like in Shigofumi or Death Parade. You can’t see, hear, or speak…
…but that’s okay. That’s okay because you can’t feel pain. Not your pain. Not their pain. Not their pain causing your pain. It might be an escape from life, but it’s also the ultimate escape from pain.
Does that not seem cruel?
“After all, suicide isn’t just about you.”
It’s a simple thought, I know, but when people are so self-absorbed that they can’t exercise a reasonable amount of imagination and not grasp this basic fact, it’s a victory for self-centeredness. It is the defeat of empathy. I understand how much individual liberation can be enriching. I understand how much negativity can be consuming. I’ve indulged and suffered from both. People are simultaneously individual and social persons.
People can commit suicide, and if they’re bent on it, they can usually accomplish it if they’re determined enough. It’s not that hard to die. But once you die, there are no regrets. You can’t regret killing yourself once you’re permanently gone. You can’t see the consequences of your act, hear the people you affected, and speak to the people you made suffer. Shigofumi and Death Parade gives many of its characters a second and final chance to in order to see through a perspective they otherwise neglected even glimpsing while they were still alive, but for us, the viewers, we can’t develop empathy post-mortem.
If you’re absolutely sure that none of the people you care for will suffer, you sincerely and straightly believe that your current pain is worse than any of the potential pain you might inflict on people who care for you, or you don’t even care, then go on ahead. Kill yourself.
If not, then develop some empathy for the living.

domain: literature


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Stan Zimmerman and Christian McLaughlin’s new one-act comedy, Meet & Greet, is a laugh-filled satire of the television casting process.
On a scorching day in the San Fernando Valley, four actresses arrive at a casting office to try out for the part of the ‘older woman’ in a sordid sitcom about a May-December romance. They include Broadway diva Margo Jane Marsden (Carolyn Hennesy); former sitcom co-stars Belinda Reid (Vicki Lewis) and Teri Valentine (Teresa Ganzel); and housekeeper-turned-reality-star Desiree White (Daniele Gaither).
Initially convinced she’s a shoo-in for the role, Margo is appalled to learn she is being forced to audition with actors that she considers her inferiors. Belinda, who has spent the past twenty years blaming her former co-star for her various failures, is equally aghast to find herself face-to-face with the bubbly, innocuous Teri once again. And the hot-headed, no-nonsense Desiree has no acting experience at all, a fact Margo finds especially galling. A young, flighty casting assistant (Paul Iacono) attempts to keep all of these oversized egos in check.
The actresses are each desperate to land the part for differing reasons. Margo is unable to perform onstage anymore as her memory is failing her. Teri needs another hit to raise her profile (and help market her line of health and beauty products on QVC). Belinda has spent the past two decades diving in and out of mental health facilities while making a public embarrassment of herself. Danielle’s show has been cancelled due to her family’s refusal to endure embarrassing aspects of their personal lives exposed on television.
Zimmerman and McLaughlin’s one-act play is packed with laughs and industry jabs, and it all works wonderfully well, delivered by a game and capable cast. Hennessy, familiar to fans of the TV show True Blood as the imperious Roslyn Harris, is a riot as the better-than-everyone-else Margo. Ganzel sends up her ’80s goofy blonde image to a tee, and Lewis is all frayed nerves as Belinda. Gaither does a wonderfully vicious parody of those awful ‘real housewives’ — evoking reality star NeNe in particular, since the name of her character’s cancelled show is Cray-Cray for Desiree.
Zimmerman’s direction is fast and furious, which ideal for a piece like this as the one-liners just keep flying. Most all of them hit their intended targets. No subject is safe — social media, Netflix series, reality television and the general vapidity of Hollywood are all skewered. There’s a twist near the end that could’ve been a bad move, but the writers make it work, bring the show to a satisfying conclusion.
Meet & Greet plays various days and times during the Hollywood Fringe Festival.
Check the official schedule for reservations and information.
Review by Kurt Gardner.


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A car with poor oil pressure does not run very well. The same car with excessive oil pressure is blocked in some way and under great stress. When pressure exceeds the limits of the structure for which it was constructed, the structure will eventually fail, often catastrophically. Pressure alone can break stone, brick, steel, bone, wood and human bodies large or small.
Medical science loves to come up with theories to explain the human body. Of course, blood pressure has its place and they admit it is vital. The problem with Blood pressure with Modern Medicine is that they can’t decide what organ regulates its levels. Having a clue about anatomy which Modern Medicine apparently does not, we know that the body filters its blood via the kidneys.
When kidneys stress is high so is blood pressure. Healthy blood pressure is 120 over 80. The first number resents the pressure inside your blood vessels during a heartbeat. The second is the measure of pressure when the heart is at rest. Blood pressure is maintained via the relationship of the kidneys with the heart. Reducing Blood pressure and or maintaining healthy blood pressure takes knowing that it starts with the kidneys. If the kidneys fail the whole cardiovascular system goes down with them. Caffeine is a constrictor intensifying pressure in the body as it attacks the kidneys, heart, liver, lungs, arteries, spleen, pancreas and much more. The foods that aid blood pressure include tomatoes, kiwi, romaine lettuce and cherries to name a few. Detoxifying the body of waste is vital if we intend to maintain a healthy body including blood pressure.


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Although mobile casinos aren’t legal in all states, they can be enjoyed from any mobile device. You can even enjoy the same gaming options and bonuses as you would at a traditional casino. The bonuses and game opportunities are similar. If you’re searching for an online casino there are plenty to pick from. Among these options are mobile casinos and online casinos. These games are available no matter where you live. You can also enjoy them from the comfort of your own home.

domain: hobby


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Hello! How is August treating you? The dogs and I just got in from our evening walk and the trees are definitely showing signs of the end of summer. Some trees are already losing their leaves; they are scattered beneath like confetti from a celebration of some sort that I just missed. I love it. I love this change. This dwindling of summer, the creeping in of longer nights, the cooler air, the lengthening shadows. The Bearded Dude and I (aka my husband Jason) are going to try and sneak in one more camping trip and maybe a hike or two in the middle of next month, after he's back from his 2 week oilfield medic rotation. Amazing. I can't wait!
This isn't the post about the new paintings; the one from my trip to England, but they are nearly complete. I will be posting them here and making a new folder in the gallery section specifically for them. I have 3 left to finish and am contemplating the starting of 3 more smaller ones. I've even decided to keep one for myself. An artist and good friend of mine recommended I keep one painting for myself from every series I paint. I'm horrible at it, but with the coming of fall comes this funny nesting/purging/organizing mood that comes over me. Without fail. I have a spot picked out for it and everything. It's going in our bedroom.
This is a post about some other exciting news. Earlier in the summer I was asked to design the EP cover for a wonderful local musician named Amber Suchy. The release party is happening this Friday & Saturday in Calgary at the Ironwood and then here in Edmonton on Sept. 7th at the Blue Chair. I don't have any other details, but you should definitely check out the show if you happen to be in one or the other city on those dates. This is my 2nd album cover project ever and this year! I don't have a physical copy of the CD yet, but here is the painting I did for her cover:
Amber was a regular when I worked at the Garneau location of Transcend, and (lucky me!) she saw some of my paintings and loved my style enough to commission me to design her cover. Oh those wonderful cafe regulars, they all have a special place in my heart; commissions or no. And people wonder why I like working in a cafe! You meet cool people and sometimes get to participate in cool projects those cool people are involved in. (And I'm a coffee addict.)
I've also been asked to design a 3rd album cover for a gentleman in Winnipeg named Kevin Roy. I'm not sure what the release date for his album is yet. What a great summer for collaborations, music and new projects!
Now to get this England show done and hung before my favorite month hits.
Four days left.


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An aide to the President on social media, Lauretta Onochie, says Nigerians who flaunt lifestyles they cannot afford offline and online will be investigated by the Economic and Financial Crimes Commission as well as the Independent Corrupt Practices Commission.
The aide to the President, Major General Muhammadu Buhari (retd.), stated this on Twitter on Monday, saying such persons will be invited by the anti-graft agencies to explain the sources of their wealth and properties.
Onochie wrote, “Lifestyle Audit is now legal in Nigeria. Those who flaunt lifestyles they cannot afford can now be investigated by any of the graft agencies to produce evidence of the sources of their wealth. You can now be called upon to explain how you acquired certain properties. [email protected]_PE.”
The PUNCH had also reported that the EFCC Chairman, Abdulrasheed Bawa said the commission will from June 1 demand the asset declaration forms of bankers.
He said the decision was in line with the provisions of the Bank, Employees Declaration of Asset Act.
YOU MAY ALSO LIKE: Nigerians are watching, we can’t afford to fail, Bawa charges EFCC officials
All rights reserved. This material, and other digital content on this website, may not be reproduced, published, broadcast, rewritten or redistributed in whole or in part without prior express written permission from PUNCH.
Contact: [email protected]

domain: economics


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The reason it's called Poem 21 on LoveMekanism.Org and not Poem 32 is because I knew there would be a sequel before I wrote Poem 20: Second the One, Part 1, a poetic literature series is based on a question about what "the one" might be if there were such a thing. Having sworn off the idea but still mulling over questions of "the one" given the ability to create him hypothetically, I was intrigued.
From this creative space, I wrote Poem 20 and left room in the numbering sequence for a second installment where I originally imagined she might find "the one". After writing it, I knew that there is at least a Part 3 in the series, but obviously there is already a Poem 22, so it's back to our regularly scheduled number sequence. Now that I'm invested in the story, I did not enjoy cutting it down to a simplicity comparable to Part 1 in the series.
Who would "the one", have to be given her complexities? What would she would have to see and experience in their encounters to convince her to fall in love again? Among many other questions, those created a more fulfilling challenge to me than the challenge to maintain technical consistency. So, on to the next challenge, and ok... I am an artist :)
Look for Part 3 in the "Second the One" series wherever you read and follow Love Mekanism Project, and don't forget to follow on twitter


Warehouse and office area on 4+ acres
Main building 80′ x 220′, 17,600sf, ceiling height 13′ 8″, Concrete block with metal roof. This building is in good condition and can be divided and upgraded easily for cultivation.
Old office area 30′ x 90′ 2,700 sf, 10 ft ceiling this building will need work to bring it up to being a productive use of the square footage
East building attached 80′ x 100′, 8,000 sf is attached to maim building but will require some work to make it a productive use of the square footage


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Archaeological visit, terroir and walks
You will discover a charming historical heritage. An original visit filled with surprises mixing nature and culture.
Our first stop takes us to Villeneuve-les-Maguelone. Crossing the canal will be an opportunity to admire the flamingos and to feel the freshness of the spray. Once on the peninsula, the cathedral surrounded by vineyards is a place steeped in history. Enjoy a meal in the pine forest where you may have the chance to observe peacocks.
20 km from Montpellier, is one of the most beautiful ancient cities in the region. Murviel is a pretty medieval village, a place that will immerse you in the history of the Roman Gallos through its remains and its excavation site. A walk between the vineyards and the scrubland to discover unspoiled natural sites.
End the day in style by taking part in a wine and tapas tasting at the Château de Fourques located in Juvignac. A convivial moment shared from an ancestral cellar.
per adult from
What's included :
- Alcoholic Beverages - Tapas and wine tasting
- Entry/Admission - Chateau de Fourques
What's excluded :
- Lunch - Optional
- This is a typical itinerary for this product
Stop At: Villeneuve-les-Maguelone, Villeneuve-les-Maguelone, Herault, Occitanie
Cross the ponds dotted with flamingos then admire the cathedral steeped in history. Share a meal in a charming pine forest.
Duration: 2 hours
Stop At: Murviel-les-Montpellier, Murviel-les-Montpellier, Montpellier, Herault, Occitanie
Murviel is a pretty medieval village, a place that will immerse you in the history of the Roman Gallos through its remains and its excavation site. A walk between the vineyards and the scrubland to discover unspoiled natural sites.
Duration: 45 minutes
Stop At: Chateau de Fourques, route de Laverune, 34990 Juvignac France
End the day in style by taking part in a wine tasting at the Château de Fourques located in Juvignac. One of the three daughters of the estate will welcome you and introduce you to the history of this pretty place with 4 generations of winegrowers.
Duration: 1 hour 30 minutes
Departure Point :Traveler pickup is offered
Transport from Montpellier by air-conditioned minibus (included)Pick up in Montpellier, stop of TRAM 'Mosson' L1 or L3Wait at the tram stop for the guide to find you.Other pick-up locations on request only.
Departure Time :9:30 AM
Return Detail :-
Hotel Pickup :
- Confirmation will be received at time of booking
- Wheelchair accessible
- Stroller accessible
- Service animals allowed
- Near public transportation
- Transportation is wheelchair accessible
- Travelers should have a moderate physical fitness level
- This experience requires good weather. If it’s canceled due to poor weather, you’ll be offered a different date or a full refund
- This is a private tour/activity. Only your group will participate
- Face masks required for travelers in public areas
- Face masks required for guides in public areas
- Face masks provided for travelers
- Hand sanitizer available to travelers and staff
- Social distancing enforced throughout experience
- Gear/equipment sanitized between use
- Transportation vehicles regularly sanitized
- Guides required to regularly wash hands
- You can present either a paper or an electronic voucher for this activity.
- For a full refund, cancel at least 24 hours in advance of the start date of the experience.


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• MHWL proposes legislating the prevention of power harassment – malicious complaints mentioned clearly for the first time as “customer harassment”;
• Consultations over losing jobs rise rapidly – possible avoidance of unlimited-term contracts;
• Former teacher files suit in Mie Prefecture over fake subcontracting;
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(Translated from Japanese)


text:
The microenvironment of cancer cells, composed of extracellular matrix (ECM) macromolecules, plays a pivotal function in tumor progression. ECM preexisting modules or cryptic sites revealed by partial enzymatic hydrolysis positively or negatively regulate matrix metalloproteinase (MMP) expression and activation, further influencing matrix invasion by cancer cells. Pericellular activation of gelatinase A (MMP-2) proceeds via the formation of a complex involving its inhibitor, TIMP-2, its activator(s), MT-MMPs and alphavbeta3 integrin forming a docking system. This proteinase has been invariably linked to cancer cell invasive potential and is often predictive of a poor survival. MMP-2 degrades most ECM macromolecules and appears to act as a main 'decryptase'. ECM modulation of MMP-2 activation pathway thus influences angiogenesis and tumor growth. For instance the noncollagenous domain of alpha3 chain of type IV collagen, through alphavbeta3 integrin binding, inhibits both MT1-MMP and alphavbeta3 integrin expression from melanoma cells and empedes cell migration and proliferation. At the opposite, a particular module in elastin (VGVAPG) with type VIII beta turn conformation stimulates MT1-MMP and proMMP-2 activation through binding to S-gal elastin receptor, and increases the matrix invasive capacity of several cancer cell lines and endothelial cells. Endocytosis emerges as a main mechanism controlling MMP-2, and also other MMPs; it proceeds via the formation of a MMP-thrombospondin(s) complex further recognized by the LRP scavenger receptor. ECM undergoes conspicuous variations with aging linked to alterations of tissue organization and post-translational modifications of matrix constituents that modify cell-matrix interactions and MMP-2 activation pathway.
(c) 2002 Elsevier Science Ltd.


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As one of the major limitations of regenerative retinal therapy treatments is their delivery, we have been working on a flexible robotic system to boost the capabilities of surgeons and clinical outcomes. Our system offers wrist-like dexterity within the confined space of the eye, allowing tissue manipulation from preferential directions. This meets the requirement for micrometer scale manipulation in addition to optimising the injectors angle of attack to the targeted tissue. Miniaturised fibre-based technology affords the system with micro-scale force sensing for haptic feedback, and forward imaging. The plurality of sensors and enhanced dexterity, contrary to holding a straight instrument, allows for targeted safe delivery of regenerative therapies anywhere within the retina.
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CPP consortium to build $18 billion Iraq-Jordan pipeline
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A consortium of China Petroleum Pipeline (CPP) and private company Mass Global is set to build a $18 billion export pipeline from Basra to the Jordanian Red-Sea port of Aqaba, according to a report.
"The two companies will submit their investment to the oil ministry in March," Adel Abdel Mahdi, Iraqi Oil Minister, was quoted as saying in the Iraq-Business News report.
The firms plan to export one million barrels per day of Iraqi crude to Jordan, 150,000 bpd of which will Jordan's Zarqa's oil refinery, it said.
The pipeline will run through Anbar province, most of which is controlled by the Islamic State militants, it added.
Iraq Business News
The next phase of Qatar's mega power transmission and distribution project is expected to start in the current quarter of this year. The estimated $2bn worth ...
The number of Jordanian exports to the European market is expected to rise following a newly inked deal with the EU that relaxes the rules of origin ...
Two bridges connecting Saudi Arabia with Bahrain and Qatar via Al-Ahsa are expected to be built in the near future, Adel bin Mohammad Al-Malham, secretary of ...


To increase contact conductance between two mating surfaces, a conductive “tape” has been developed by growing dense arrays of carbon nanotubes (CNTs, graphite layers folded into cylinders) on both sides of a thermally conductive metallic foil. When the two mating surfaces are brought into contact with the conductive tape in between, the CNT arrays will adhere to the mating surface. The van der Waals force between the contacting tubes and the mating surface provides adhesion between the two mating surfaces. Even though the thermal contact conductance of a single tube-to-tube contact is small, the tremendous amount of CNTs on the surface leads to a very large overall contact conductance.
Interface contact thermal resistance rises from the microroughness and the macroscopic non-planar quality of mating surfaces. When two surfaces come into contact with each other, the actual contact area may be much less than the total area of the surfaces. The real area of contact depends on the load, the surface roughness, and the elastic and inelastic properties of the surface. This issue is even more important at cryogenic temperatures, where materials become hard and brittle and vacuum is used, which prevents any gas conduction through the interstitial region.
A typical approach to increase thermal contact conductance is to use thermally conducting epoxies or greases, which are not always compatible with vacuum conditions. In addition, the thermal conductivities of these compounds are often relatively low. The CNTs used in this approach can be metallic or semiconducting, depending on the folding angle and diameter. The electrical resistivity of multiwalled carbon nanotubes (MWCNTs) has been reported. MWCNTs can pass a current density and remain stable at high temperatures in air. The thermal conductivity of a MWCNT at room temperature is measured to be approximately 3,000 W/m-K, which is much larger than that of diamond. At room temperature, the thermal conductance of a 0.3 cm2 array of CNTs was measured to be as high as 10 W/K. The high thermal conductivity and the nanoscale size make CNTs ideal as thermal interface materials.
The CNT-based thermal tape can be used for the thermal management of microelectronic packages and electronic systems. It also can be integrated with current device technology and packaging. The material would allow for an efficient method to manage excess heat generation without requiring any additional power. Lastly, the CNT tape can be used to enhance thermal contact conductance across two mating surfaces on some NASA missions.
This work was done by Ali Kashani of Atlas Scientific for Goddard Space Flight Center. For further information, contact the Goddard Innovative Partnerships Office at (301) 286-5810. GSC-15607-1


text:
Being happy and upbeat 24/7 is a totally unrealistic requirement, yet one we are marred with. Nevertheless, feeling down very frequently could also be a symptom of depression or even anxiety. In reality, our moods go through ups and downs, but, the low points are usually influenced by factors that we would never even dream of suspecting.
8 Elements that negatively impact your mood
You could be in for a surprise...
1) The weather
If you're anything like me, you'll struggle to leave the comfort of your bed whenever you hear raindrops thrashing against your windows. Yet, when the sun is shining, and you are woken by its gentle morning rays, it's a whole different story! When the weather is good, we simply feel better within ourselves and find it much easier to adopt a positive mood, and even to step out of our comfort zone. Whereas, when the temperatures wouldn't look out of place for the Arctic, we can barely be bothered to move from the kitchen to the couch.
2) The media you follow
At the height of the Coronavirus pandemic, many of us noticed that our mental health was negatively impacted by the constant anxiety-raising subjects that 24-hour news channels bombarded us with. Being constantly exposed to gloomy death figures and other sad events can definitely wear us down and sap our quality of life. It is certainly important to remain informed in this day and age, but that's not to say that the media we consume should have side effects on us. Plus, it's primordial to know when enough is enough for you and to therefore switch off.
3) Social networking sites
Time often seems to stop still when we scroll through Instagram and various other social media sites, and although this seems pretty inoffensive, the content we see often plunges us into a bad mood. By flicking through stories and looking at posts, we subconsciously compare our bodies to those of the models we see and even start to feel bad about not looking like the filters we use. These platforms typically plunge us into a spiral of negative self-esteem and reinforce within us the idea that we simply aren't good enough.
>>> Read; Why are Instagram filters dangerous for our self-confidence?
4) Your diet
Let's face it, everyone likes to binge out on a good burger and fries every once in a while, however, certain foods really make us feel bad about ourselves. Instead of opting for complex carbohydrates the next time you're looking for a snack, why not go for something a little richer in fiber? Your body will definitely thank you afterward.
5) Your sleep quality
Your parents no doubt drilled into you the necessity of 8 hours of sleep per night, yet, that's not to say you ever follow their advice. However, it is in fact scientifically proven that a poor sleep pattern can plummet your mood and make you feel terrible. When you are sleep-deprived, you simply don't want to do anything other than feel sorry for yourself, plus, not getting enough beauty sleep makes many of us extremely irritable too...
6) How busy you've been
Stress and anxiety are two of the 21st century's biggest enemies. Nowadays, we never really seem to have the time to relax. What with our bosses expecting us to be at their beck and call 24/7 and various other societal pressures, we barely ever get time to wind down and blow off steam. Sitting around and doing nothing is a simple pleasure, but it is a necessary one.
>>> Find out what anxiety can do to your body
7) How much you feel loved
Naturally, when we feel loved and cared for, we feel good about ourselves. However, at times, even the slightest of hiccups can put us on edge and make us doubt things; whether that be an argument with our partner or even a disagreement with a family member. Feeling unsure of other people's feelings towards us is certainly a surefire way to throw us into a terrible mood.
8) Lack of exercise
Now, I'm not saying that running a marathon a day is the solution to happiness, however, light daily movement, such as a short walk, or a yoga session, has what it takes to get us smiling and feeling positive about life.
How do I know my mood?
Identifying your mood is an essential step in taking care of your mental and emotional health. To do this, it's helpful to ask yourself a few simple questions throughout the day. Take a moment to think about how you feel inside and to name your emotions: are you happy, anxious, sad, angry, calm, or excited? Try to put your emotions into words. Then look for physical signals: muscle tension, rapid breathing, or a feeling of well-being? When you can name and identify your emotions, you can better understand what triggers them and how they influence your actions and reactions. It also enables you to look for ways to manage your emotions in a healthy and constructive way, whether through meditation, exercise, communication, or other stress management techniques.
Editor's opinion - Toxic positivity isn't the solution, either...
Feeling down is normal, but because expressing negative feelings is pretty much taboo, lots of us pretend to be happy, when on the inside we feel awful. Feeling judged for feeling down is fairly common in our society, and this added pressure often pushes us towards toxic positivity
and therefore leads us to bury our feelings and place a band-aid upon them. Whatever you feel; positive or negative, you should be able to express your emotions in a safe environment.
🤗 Understand yourself, accept yourself, be happy... Let’s do it here and now!
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domain: psychology


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With the increasing usage of digital technology in our culture, particularly during the Covid-19 pandemic, the presence and use of smart devices and other technologies in our family’s lives can feel excessive and overwhelming for parents to manage. Through discussion of emerging research as well as her experience on the front lines counseling Digital Age college students at VCU and as a mom of two young boys, Nina will provide parents with helpful insight into the potential cognitive, social, and mental health effects of high screen use, and share practical strategies to confidently promote a healthy & mindful approach to screen use and well-being for the entire family.
Nina Schroder, MSW, LCSW is a mental health therapist who specializes in the treatment of anxiety and depression of college students and young adults and studies the effects of high screen use on mental health, emotional resilience, and overall well-being. During her time at VCU’s University Counseling Services, Nina helped develop and lead a successful and popular 5-week skills-building group program, Reclaim Life from Anxiety & Live Well, which promotes skills and healthy mindsets to increase resilience and well-being. She also has been a regular lecturer for the Science of Happiness course and LEAD program. Nina is passionate about growing emotional resilience and well-being in the Digital Age, and delivers lectures and workshops both locally and nationally. She lives in Richmond, Virginia with her husband and two school-age children.