ANNAPOLIS – Maryland fire and rescue crews will have one less “bio-headache” when American Type Culture Collection moves to Northern Virginia this month and takes its store of germs with it.
But local emergency crews cannot relax yet — Montgomery and Frederick counties are still home to America’s foremost research institutions on diseases and germ warfare.
Not only are Fort Detrick and the National Institutes of Health still around, but they will soon be home to two of the only three “biosafety level 4” labs in the country.
Biosafety level 4 is the highest level of containment for biomedical research, as set by NIH and the Centers for Disease Control.
Level-4 facilities are pressurized, sealed buildings with “submarine-style doors,” dunk tanks and special floors impervious to chemicals. Everyone in a level-4 lab works in special suits that have independent air supplies.
ATCC, by contrast, never reached level 4. The company, which was in the news recently for selling inactive anthrax and bubonic plague cultures to two men in Nevada, studies, stores and sells germs.
Montgomery fire officials said they are confident they can deal with the new level-4 lab at NIH, which is set to open this spring to study tuberculosis.
“I’m as comfortable as you can be with these types of things,” said Montgomery County Fire Chief Jon C. Grover, who said his teams are prepared for any fire at NIH.
That is little comfort to Arlene S. Allen, who said life in Stratton Woods, just three miles from NIH, is like waiting for a bomb to explode.
“It’s just a matter of time before the NIH is telling us they’re sorry,” said Allen, a former president of the North Bethesda Congress of Citizens Associations. “It should be in a desert where if they make a mistake, it won’t affect so many people.”
But NIH spokesman Don Ralbovsky said neighbors have no reason to worry.
“We take all necessary precautions for safety,” he said.
At the Army Medical Research and Materiel Command at Fort Detrick, which is already classified as a level-4 facility, the book of worst-case scenarios is the size of the Manhattan phone book, said a spokesman.
Chuck Dasey said those scenarios were developed as part of a 1989 environmental impact statement for the Army base in Frederick County.
But Dasey said he is not worried because of “the small quantities of bio-hazards and redundant safety features of the level-4 facility” at Fort Detrick. He insisted that “fire or even an earthquake could not cause widespread contamination.”
Level-4 labs are required to have built-in safety measures in the case of an earthquake or attempted theft. Powerful air filters and security systems keep bio-hazards from getting out of the building.
Dasey said that, if a fire were to break out, Fort Detrick crews would likely just let it burn because intense heat destroys biological materials.
Montgomery officials said the same thing — let it burn.
Grover said the heat from any large fire would kill any cultures, so letting it burn would not pose any health risks.
Montgomery County hazmat team leader Robert Stephan agreed that a burning level-4 building would be left to burn, and added that his crew is ready for anything.
“It’s like anything else,” Stephan said. “If it’s not handled properly, it’s not good. But, when it is, it can benefit a lot of people in the long run. This is the cost of progress.”
Ed Herbert, senior environmental manager at the Montgomery County Department of Environmental Protection, said he did not consider ATCC or NIH “to be a major hazard in our county.”
Herbert said he can think of only one letter of citizen concern about ATCC, after it was reported that the bio-tech company sold germ cultures to Iraq a few years ago. He said he was sorry to see the company go.
Officials at ATCC’s new Northern Virginia home, meanwhile, said they are ready.
Prince William County Fire Chief Mary Beth Michos — who spent 21 years in the Montgomery County Fire Department — said she is “very comfortable” having ATCC in her back yard.
“I know ATCC has gotten a lot of focus recently, but a lot of companies have chemicals and bio-hazards,” she said. “Our department is ready.”
Michos’ code-enforcement team has been working with ATCC to assure a smooth transition, she said. The company is set to open for business in Prince William County March 23.


Cabinet Minister in Maharashtra government Eknath Shinde on Tuesday said that the work on an 11 km route of Nagpur Metro has been completed and soon it will be inaugurated by Chief Minister Uddhav Thackeray.
“Nagpur Metro’s Lokmanya Nagar to Seetabaldi, an 11 km stretch work is completed and it will be soon inaugurated by Chief Minister Uddhav Thackeray,” Shinde said in a statement.
To take a view of all Metro related works across Maharashtra a review meeting was conducted by minister Ekanath Shinde in Mantralaya today.
The statement said that it was informed in the meeting that a complete 32.50 km stretch of Pune Metro will be functional by 2022.
Minister Shinde has asked officials to complete the work before time. Shinde also said that Saint Tukaram Nagar to Fugewadi route to start functioning from April in Pune.
This is complete five km stretch and Minister Ekanath Shinde has directed to complete the work by end of March to open it for passengers by the end of April.
Likewise, he has also directed to complete the work of other phases between Vanaz to Ramwadi a 5 km stretch by end of June and make it functional for people by July.
Also, the revised Detailed Project Report (DPR) for Thane metro project will be finalised and approved by the state government by February, the statement added.


Published at Sunday, September 16th 2018. by Beverley Vasquez in Blanket.
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There are many types of coverlets and bedspreads to choose from. Luxurious bedding, like the type at the Hilton Hotel, is often referred to as "heavenly" or "fit for a king." The truth is, you don't have to be royalty to enjoy a good night's sleep.
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Friday morning, I had the van to myself. Joy wasn’t feeling well enough to go to co-op, so I was on my own. I turned out of my neighborhood and headed down Washington Road towards Augusta National Golf Club and I-20 to be greeted by this beautiful sight.
There were just enough clouds to carry the gorgeous color of morning all across the sky. It looked more like a beach sunrise or sunset than anything I’ve recently seen in the city. But, it was such a beautiful sight that I grabbed my Cybershot out of purse and snapped a few shots. This one is definitely my favorite.
You know, God is so good to us. He could have created our eyes to only see in black and white, but He chose to give us the gift of sight that can see color. He could have made our mornings and our nights the same as our days with a simple change of blue sky to a dark night. But he didn’t. He chose to give us an exciting new sunrise and sunset each day. Of course, some are more beautiful than others….. like all of our days. And sometimes we’re too busy to catch a glimpse of the beauty. Then there is the fact that perspective plays a large role in what we see. The sunrise at a beach is so intense and stunning. Maybe that’s because we’re not distracted by all the things that distract us at home or in the city – the physical things and the emotional.
I’m so thankful that I was given the gift of the ability to see color. And I’m thankful that, on this particular morning, God painted the sky with color so intense, so far and so wide that even I couldn’t miss it. Lord, thank you.

domain: artistic


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A randomized controlled trial of endoscopic steroid injection for prophylaxis of esophageal stenoses after extensive endoscopic submucosal dissection
BMC Gastroenterology volume 15, Article number: 1 (2015)
Esophageal stenosis following endoscopic submucosal dissection (ESD) is a serious adverse event that makes subsequent management more difficult.
This parallel, randomized, controlled, open-label study was designed to examine whether local steroid injection is an effective prophylactic treatment for esophageal stenoses following extensive ESD. This single center trial was conducted at the Keiyukai Hospital, a tertiary care center for gastrointestinal disease in Japan [University Hospital Medical Network Clinical Trial Registry (UMIN-CTR) on 15 September 2011 (UMIN000006327)]. Thirty-two patients with mucosal defects involving ≥75% of the esophageal circumference were randomized to receive a single dose of triamcinolone acetonide injections (n = 16) or be treated conventionally (n = 16). The primary outcome was the frequency of stricture requiring endoscopic dilatation; the surrogate primary endpoint was the number of dilatation sessions needed. Secondary outcomes included adverse event rates, the minimum diameter of the stenotic area and the duration of the course of dilatation treatments.
The frequency of stricture was not significantly different between the groups because of insufficient statistical power, but the number of dilatation sessions required was significantly less in the steroid group (6.1 sessions [95% confidence interval, CI 2.8–9.4] versus 12.5 [95% CI 7.1–17.9] sessions in the control group; P = 0.04). The perforation rate was similar in both groups. The minimum diameter of stenotic lumens was significantly greater in the treatment group than controls (11.0 mm versus 7.1 mm, respectively; P = 0.01). The perforation rate was not significantly different between the groups (1.0% versus 0.5% in the treatment and control group, respectively). Steroid injection was effective in cases of mucosal defects encompassing the entire esophageal circumference.
Prophylactic endoscopic steroid injection appears to be a safe means of relieving the severity of esophageal stenoses following extensive ESD.
In Japan, endoscopic submucosal dissection (ESD) is widely accepted as a standard treatment for early esophageal squamous cell carcinomas without documented metastasis. The ESD technique has been shown to reduce the risk of local recurrence, and perforations arising as a consequence of treatment are generally well tolerated . As ESD can excise larger lesions than endoscopic mucosal resection, it is becoming increasingly popular, but esophageal stenosis after removal of large lesions by ESD is a major concern. Mucosal defects extending over three-quarters of the circumference of the esophagus after endoscopic resection are closely associated with the subsequent development of esophageal stenosis , which can cause dysphagia and impair quality of life.
Patients with esophageal stenosis are frequently treated by endoscopic dilatation therapy. The risk of perforation complicating the procedure increases with the number of therapeutic sessions . It is important to identify ways of preventing esophageal stenosis after ESD, and minimizing the complications associated with treatment when it does arise. Treatment options for esophageal stenosis include mechanical dilatation with a bougie or balloon, stent placement and autologous keratinocyte implantation . Dilatation therapies may, however, have a higher incidence of adverse events and recurrence rates than previously thought [5-7]. Therefore, simple, safe, reliable and inexpensive approaches are needed to cope with iatrogenic esophageal stenoses.
Systemic  or local [9,10] administration of steroids is reported to be an effective means of addressing esophageal stenosis after ESD, as well as for peptic stenosis [11-13]. Although systemic steroids should be avoided in patients with diabetes mellitus or hypertension, locally administered steroids appear to be safe in the vast majority of patients . Locally administered steroids have minimal systemic effects owing to the small dose administered and short duration of exposure . Previous retrospective and controlled prospective studies of endoscopic steroid injection therapy have found that the incidence of esophageal stenosis following ESD in patients treated with steroid was 10–19%, compared with 66–75% in untreated control groups. In addition, steroid injection therapy significantly reduced the number of required dilatation sessions.
To our knowledge, no randomized studies to date have analyzed the potential preventative benefits of endoscopic steroid injection therapy, or whether it is safe and effective, for stenosis caused by a mucosal defect involving the entire circumference of the esophagus after ESD. We undertook a prospective, randomized controlled trial to analyze the prophylactic effects of endoscopic steroid injection therapy for esophageal stenoses complicating extensive ESD.
This randomized, controlled, open-label study was performed at Keiyukai Sapporo Hospital, Japan. All participants gave their written informed consent, based on the Helsinki Declaration (1964, 1975, amended in 1983, 2003 and 2008) of the World Medical Association, and the Ethics Committee of Keiyukai Sapporo Hospital approved the study protocol. The study was designed according to the CONSORT guidelines and was registered with the University Hospital Medical Network Clinical Trial Registry (UMIN-CTR) on 15 September 2011 (UMIN000006327).
Patients who had undergone ESD to treat histologically confirmed early squamous cell carcinoma of the esophagus from February 2010 to October 2011 and who were expected to have a mucosal defect encompassing ≥75% of the circumference of the esophageal mucosa after ESD were eligible for the study. Patients who received additional adjuvant treatments, such as surgery or chemoradiation therapy, and patients who were not regularly or adequately followed-up were excluded. Depth of tumor invasion was determined based on the findings of endoscopy and/or endoscopic ultrasonography. Mucosal to slightly invasive submucosal cancers (of invasion less than 200 μm in depth) were regarded as indications for ESD. Removal of a carcinoma involving two-thirds of the circumference of the esophagus by ESD was expected to result in a mucosal defect spanning more than three-quarters of the circumference. Patients enrolled in the study were randomized to receive steroid injection therapy or to be treated conventionally. Randomization was computer-generated with concealed allocation using sequentially numbered containers. Data were collated at Sapporo Medical University and independently analyzed by one author (Y.A.). The baseline demographic and clinical characteristics of the study population were compared on the basis of age, sex, tumor location, proportion of the esophageal circumference involved, number of multiple Lugol voiding lesions , clinical T factor  and follow-up period (Table 1). All ESD procedures (Figure 1A–C) were performed as described in our previous report . The characteristics of the ESD procedures undertaken in the treatment and control groups were compared on the basis of the size of the tumor and resected specimen, depth of invasion, operation time, pathological margin, mucosal circumferential defect and peri-procedural perforation (Table 2).
Protocol for endoscopic steroid injection and dilatation therapy
As previously described [9,10], patients who did not develop immediate complications, such as perforation or bleeding, during the ESD procedure and who had been allocated to the steroid injection group were endoscopically injected with triamcinolone acetonide (Kenacort-A®, 40 mg/ml, Bristol-Myers Squibb, Anagni, Italy) immediately after the procedure. Triamcinolone was diluted with 0.9% NaCl to a final concentration of 10 mg/ml, then 0.5 ml aliquots were injected at the base of the artificial ulcer using a 25-gauge, 3 mm needle (TOP Corporation, Tokyo, Japan; Figure 1D). Injection commenced at the distal edge of the ulcer base and was repeated evenly at points 10 mm apart towards the proximal edge, taking care to avoid injuring the muscularis propria.
Esophagogastroduodenoscopy (EGD) was performed to assess for stenosis, bleeding or perforation at the injected sites 6 days after treatment (Figure 2). Barium contrast esophagography was performed in patients who complained of dysphagia, or 4 weeks after the last EGD if patients were asymptomatic, to quantitatively assess stenosis (Figure 3). Esophageal stenosis was defined as an esophageal diameter <11 mm, rather than the inability to pass the gastroscope (which had a diameter of 9.8–11.0 mm) or inability to achieve or maintain a diameter of 14 mm despite dilatation every 2–4 weeks [5,16]. The luminal diameter was estimated by measurement of the minimum diameter of the stricture on esophagography (for examples, see Figures 3 and 4). Dilatation therapy was performed every 1–4 weeks as previously described . Briefly, dilatation was performed in the outpatient department under fluoroscopic guidance using a Maloney (Medovations, Milwaukee, WI) or Savary (Wilson Cook Medical, Winston-Salem, NC) wire-guided dilator . Dilatation therapy was considered successful when patients did not report any symptoms of dysphagia without having needed dilatation in the previous 4 weeks (Figure 5).
The incidence of esophageal stenoses and the frequency of dilatation sessions required were compared in the treatment and control groups. Independent t tests were used to compare age, resection size and procedure time. The primary study endpoint was the frequency of stricture requiring endoscopic dilatation for esophageal stenosis after ESD. A surrogate primary endpoint, the number of dilatation sessions required, was subsequently included in the analysis because the primary endpoint did not reach statistical significance. Secondary endpoints included the frequency of complications that occurred as a consequence of either local steroid injection or endoscopic dilatation, the minimum diameter of the stenotic area and the duration of the course of dilatation treatments (Tables 3 and 4). The number of patients to be enrolled was determined in advance using a power calculation for two-sample proportions test based on expected bougienage rates of 13% with and 60% without steroid injection, informed by previous reports of esophageal peptic stricture rates , with an α error of 0.05 (two-tailed) and a β error of 0.2. Consequently, the number of patients required in each group was calculated as 16 using R statistical software . Post hoc analysis was also undertaken to compare the group of patients with whole circumferential mucosal defects (WCMD) with the group of those with lesions that involved less than the whole circumference (non-WCMD, NWCMD; Table 4), and a further analysis of the characteristics of patients with WCMDs was made (Table 5). All other statistical analyses were performed using IBM SPSS Statistics version 21 (IBM Japan, Tokyo, Japan). Chi-square tests were used to compare nominal and ordinal variables, with the exact P value based on Pearson’s statistics or the Monte Carlo method applied as appropriate. We used t tests or Mann–Whitney tests for ratio scale variables, and for all tests a two-tailed P value of <0.05 was considered statistically significant.
Recruitment began in February 2010 and the last follow-up was in October 2011. The trial ended because data were considered complete. During the study period, 209 patients with 256 lesions underwent ESD in our hospital, 42 of whom (20.1%) were enrolled in the study because they were expected to have mucosal defects extending over three-quarters of the esophageal circumference due to the ESD. Since one of these 42 patients declined to participate, in total 41 were enrolled and randomized. 21 were allocated to the injection (treatment) group whereas 20 were allocated to the non-injection (control) group. However, after ESD, nine patients were excluded from the study: one whose follow-up was inadequate and eight who received additional therapy. Of the latter eight patients, seven had submucosal invasion that exceeded 200 μm and one had lymphatic invasion despite a depth of invasion of only 180 μm. Ultimately, 16 patients were allocated to each group (Figure 6).
Comparison of treatment and control groups
Patients’ baseline demographic and clinical characteristics (Table 1) and those of the ESD procedures (Table 2) were not significantly different between the groups. No patient experienced perforation caused by steroid injection or any other side effects of steroids. The frequency of stricture was not significantly different between the treatment (n = 10, 62.5%) and control (n = 14, 87.5%) groups (P = 0.22, Table 3). The mean number of sessions of dilatation therapy was significantly lower in the treatment than in the control group (6.1 sessions [95% confidence interval, CI 2.8–9.4 sessions] versus 12.5 sessions [95% CI 7.1–17.9 sessions]; P = 0.04). The perforation rate caused by dilatation procedures was 1.0% (one out of 97 sessions) in the steroid injection group and 0.5% (one out of 200 sessions) in the control group. The mean minimum diameter of stenotic lumens just before dilatation therapy was greater in the treatment group than controls (11.0 mm [95% CI 8.5–13.4 mm] versus 7.1 mm [95% CI 5.5–8.6], P = 0.01; Figure 4). The duration of dilatation therapy was 3.5 months in the treatment group and 6.1 months in the control group, but the difference was not statistically significant (P = 0.11, Table 3).
Post hoc comparison between patients with whole and non-whole circumferential mucosal defects
There were no significant differences in the baseline demographic, clinical or ESD characteristics of the 10 patients with WCMDs compared with the remaining 22 with NWCMDs (data not shown). The incidence of stricture was significantly more frequent (100% versus 63.6%, P = 0.035) and the mean number of dilatation therapy sessions required was significantly more (16.3 versus 6.1 sessions, P = 0.013) in those with WCMD lesions. The perforation rate caused by dilatation procedures was similar: 0.6% (one out of 163 sessions) in the WCMD group compared with 0.7% (one out of 134 sessions) in the NWCMD group. The mean minimum diameter of stenotic lumens immediately before dilatation therapy was smaller in the WCMD group (7.2 versus 9.9 mm in the NWCMD group) but the difference was not significant (P = 0.10). The mean duration of dilatation therapy was significantly longer (8.1 versus 3.3 months, P = 0.047) in the WCMD group (Table 4).
Subgroup analysis of the whole circumference mucosal defect group
Comparisons of patients in the WCMD subgroup treated with steroid (n = 5) and those treated conventionally (n = 5) revealed no significant differences in baseline demographic, clinical or ESD characteristics (data not shown). The only treatment-related factor that differed significantly between the groups was the mean number of dilatation therapy sessions required, which was lower in those treated with steroids compared with controls (10.4 sessions [95% CI 6.0–14.8 sessions] versus 22.2 sessions [95% CI 9.0–35.4 sessions], respectively, P <0.05; Table 3).
Strictures have been observed to develop when the mucosal defect extends beyond three-quarters of the esophageal circumference in 68–92% of patients [2,5,9]. Because of the recent trend of treating larger lesions by extensive ESD, the number of patients with post-ESD strictures is increasing. These strictures interfere with subsequent management and impair quality of life. We therefore designed a randomized, controlled trial to examine the efficacy of endoscopic triamcinolone injection in preventing esophageal stenoses after extensive ESD, including patients with mucosal defects encompassing the entire circumference of the esophagus.
We found that endoscopic triamcinolone injection did not reduce the frequency of stricture formation, but reduced the mean number of dilatation sessions per patient from 12.5 to 6.1, suggesting that steroid injection may partially relieve esophageal stenoses. No steroid-related adverse events were observed, and the perforation rate during dilatation procedures was similar in the treated and control groups (1.0% versus 0.5%, respectively). These results suggest that a single prophylactic dose of steroid administered after ESD is safe and well tolerated. The mean minimum diameter of stenotic lumens immediately before the first dilatation treatment was significantly greater in the treated group than controls (11.0 versus 7.1 mm, respectively). The differences observed in duration of dilatation therapy were not statistically significant. Our trial is the first to demonstrate the partial but significant prophylactic effect of steroid injection on stricture formation in this clinical setting.
Hanaoka and colleagues previously stated that a randomized controlled trial comparing a single injection of steroid at the time of dilatation therapy may not be ethically acceptable, as the efficacy of steroid injection therapy is well recognized . Furthermore, they stated that it would be better justified for a future controlled trial to compare multiple steroid injections with systemic steroids or a different steroid injection regime. However, previous studies – including theirs – had excluded patients with circumferential defects from their trial, as these patients are known to develop extremely severe strictures [8,19]. Moreover, patients with WCMDs have been reported to require as many as 32 dilatation sessions , highlighting the challenges faced by clinicians in these cases. Although we are encountering more patients with circumferential mucosal defects in our clinical practice, the best way of managing them has not been determined. The results from our post hoc analysis confirm that patients with WCMDs are more likely to develop strictures, require more dilatation sessions and longer duration of treatment, but that they benefited most from a single prophylactic steroid injection after ESD. In patients with WCMDs and esophageal diameters of approximately 7 mm, prophylactic steroid treatment almost halved the number of dilatation sessions needed and the overall duration of treatment. This in itself is a clinically important finding, not least because a reduced incidence of esophageal perforation would be likely to reduce morbidity and mortality. As it is well recognized that patients are at a lower risk of esophageal perforation if they undergo fewer dilatation treatments , prophylactic steroid injection might also improve patient safety, although as perforation rates are so low a large surveillance study would be needed to detect a difference.
Our findings also concur with those of previous studies, which showed that patients with smaller mucosal defects also benefited from endoscopic steroid injections to prevent post-ESD strictures. Our study may not have been adequately powered to detect these smaller – but nonetheless clinically relevant – differences in the frequency of stricture formation. Our results should be further confirmed by a large well-powered randomized controlled trial, which should also examine whether multiple steroid injections, administered during dilatation treatments, might benefit those patients that go on to develop esophageal stenoses.
A course of oral prednisolone has been reported to be an effective means of preventing strictures . Endoscopic steroid injection is preferable to oral prednisolone in patients with diabetes mellitus, those who experience immediate or delayed adverse events after ESD, or those who require additional treatment for submucosal invasion. The systemic side effects of a locally injected steroid would likely be negligible compared with those of a systemic steroid. Histopathological analysis of excised ESD specimens showed that seven patients had tumors invading the submucosa beyond 200 μm and thus required additional therapy. Oral prednisolone would likely increase the risks associated with surgery, making it an obstacle to immediate surgical intervention. It has previously been reported that oral steroid therapy led to only three patients with WCMDs requiring a mean 0.7 sessions of dilatation therapy . Thus, it remains unclear whether locally or systemically administered steroid is superior for patients with WCMDs. A head-to-head comparative study may establish a standard prophylaxis for esophageal stenosis caused by ESD.
The estimated sample size of 16 patients per group was determined by a power calculation based on expected stricture rates of 13% and 60% with and without steroid injection, respectively, informed by previously published data on esophageal peptic strictures . These assumptions are now supported by another study , which showed that the proportion of strictures caused by ESD was 10% in steroid-treated patients and 66% in an historical control group. Nevertheless, our study might have been inadequately powered, as the stricture rates were 62.5% in the treatment group and 87.5% in the control group, a likely consequence of including 10 patients (31.3%) with circumferential mucosal defects. Furthermore, the mean numbers of dilatation sessions required in our study were higher than in previous reports , again likely a consequence of the relatively high proportion of patients with circumferential lesions. The patients in our study with NWCMDs underwent a similar mean number of dilatation sessions to a broadly comparable group of patients in a previous report . Our study has other limitations. First, it was an open-label design conducted by a single endoscopy specialist in a single specialist center. Second, concealment was based only on pseudo-randomization. Finally, the primary outcome measure was not significantly different between the groups, and some of our conclusions of therapeutic benefit are based on post hoc or subgroup analysis.
In summary, prophylactic endoscopic steroid injection can relieve the severity of esophageal stenoses following extensive ESD. Future studies should attempt to optimize steroid injection therapy to establish the best means of preventing stricture formation in patients at risk of developing esophageal stenosis. As it is well recognized that patients are at a lower risk of esophageal perforation if they undergo fewer dilatation treatments , prophylactic steroid injection might also improve patient safety, although as perforation rates are so low a large surveillance study would be needed to detect a difference.
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We thank Assistant Professor Y Hamamoto of the Division of Gastroenterology and Hepatology, Keio University School of Medicine, Japan, for providing valuable advice on the clinical trial, and Assistant Professor M Nojima of the Division of Advanced Medicine Promotion, The Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, for registration with the UMIN-CTR.
The authors declare that they have no competing interests.
HT carried out the endoscopic therapeutic maneuvers, and participated in the conception and design of the study. YA performed statistical analyses, and participated in drafting of the manuscript. SO carried out the endoscopic therapeutic maneuvers. JK participated in helping endoscopic maneuvers. KH participated in data acquisition. HT participated in the interpretation of data sequence alignment. YS participated in the conception and design of the study and performed critical revision of the manuscript. MH conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.
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Takahashi, H., Arimura, Y., Okahara, S. et al. A randomized controlled trial of endoscopic steroid injection for prophylaxis of esophageal stenoses after extensive endoscopic submucosal dissection. BMC Gastroenterol 15, 1 (2015). https://doi.org/10.1186/s12876-014-0226-6
- Esophageal stenosis
- Local injection
- Endoscopic submucosal dissection (ESD)
- Early squamous cell carcinoma of esophagus

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American companies operating in the country have pledged to offer the needed assistance to the government in its EBOLA preparedness efforts.
The Deputy Minister of Health, Dr Victor Banpoh, said in Accra that needs kept changing depending on developments with regard to the outbreak of the deadly viral fever and called for the assistance of corporate bodies to meet such growing needs.
At an evening with the Ambassador of the United States, Mr Gene A. Cretz, the President of the American Chamber of Commerce (AMCHAM), Mr Philip Ayivor, made it clear that although the companies were taking individual measures to prepare against the deadly disease which had affected the growth of affected countries, the companies were also willing to assist the government to meet emerging needs which may not have been initially factored at the planning of the response strategy.
The meeting, organised at the instance of AMCHAM, saw some companies taking turns to share their individual EBOLA preparedness and emergency response measures put in place to protect their workers and their families and the immediate communities in which they operate.
Newmont Gold Ghana, General Electric (GE), CocaCola Bottling Company Ltd and PwC were among the companies that shared the measures they had taken.
Some of the measures are as robust as what pertains at the national level which the companies said would also complement moves by the government to prevent EBOLA from coming into Ghana or be adequately prepared to deal with actual cases.
A common thread among the measures is awareness creation among staff, community and families about how to identify the disease, how to prevent it and what to do in the case of an outbreak.
Newmont Ghana said it had taken delivery of personal protective equipment (PPE), medical supplies and trained a nurse on how to handle an EBOLA case until the case is transferred to an isolation centre.
“We have done an EBOLA outbreak simulation exercise and out of the lessons, we have designed protocols and procedures to follow,” a representative of the mining company said.
Newmont also has thermal scanners on its premises similar to those at the Kotoka International Airport.
Coca-Cola has also taken delivery of medicals, PPEs, set out case handling protocols and has restricted visits to its facilities in the three most EBOLA affected West African countries — Liberia, Sierra Leone and Guinea.
It has also set up an emergency action plan with an escalation matrix for both affected and non affected African countries, with protocols on evaluation.
PwC Ghana office offers services to those countries most affected and, therefore, has carried out sensitisation in its Ghana office and has withdrawn some staff back to Ghana, while dispatching a few to carry out assignments when necessary.
GE ,on the other hand, has sensitised its 1,500 staff in Ghana and Nigeria to the disease, training other people to become EBOLA educators and has donated items to support countries affected by EBOLA.
The company’s representative, Mr Divine Akabah, said it was ready to assist Ghana.
source : Graphic Online

domain: news


Listen to The Rhythm of Laptops
Have you ever tried to listen to the operating sounds of computers? It is a very special experience to hear the opening and closing sounds of laptops. Yet these steps are often neglected by the users. The soundstage is pretty compressed, and you really need to concentrate before you can imagine HP pavilion dv2000 battery instruments around you. The speakers will go on sale starting this month and should be availabe in your local hardware store. He used Prey to collect location data and images, and he networked with Twitter friends to find the thief. However, these are nonvolatile memory chips that can retain information the way hard drives do. Let you get to the web browser as fast as possible. The fact that it has no moving parts means that an SSD is much more efficient in terms of energy usage, more durable, quiet, and much faster than a hard drive.
The Luce Solar Panel Powered PC, would be the green machine of the computer world, with two solar panels, one on the back of the lid and the other is place below the touch screen style keyboard so that there is a double dose of solar energy being absorbed whilst the laptop is in operation. "The dogs become acclimatised to the type of Inspiron e1705 battery objects they will come across every day," explained dog handler Pc Steve Madden. One of the screenshots from Mr. Kaufman's stolen computer included an email with a business name. You boot a laptop running Chrome OS in under 10 seconds.
For this reason, a computer that uses an SSD as the main storage device boots and shuts down very fast and can resume from sleep mode instantly. The speakers dont have any built in battery of their own so cannot be used without plugging it into a power source. I'll have more details about the Inspiron 1420 battery design and performance of each device as I put them through the paces. You can check out my unboxing video for more details after the break, but let's take a look at what Google is trying to do with Android and Chrome. Toshiba also anticipated customer's propensity to personalize their gadget by issuing the Thrive to come with a removable back plate.
He was even able to give them the precise location of the laptop, using an application called Hidden. Nevertheless, this is new ground, this laptop cannot be compared with a conventional laptop in any way, the fact the Luce is made from clear polycarbonate just shows how different this concept would be. In a statement accompanying the Canon bp-711 product launch, Toshiba said that its new gadget will hit the stores by July 10 and will be powered by Android's Honeycomb. A Google search revealed it to be a cab company where he assumed the man worked.
There's HDMI, which is the best method if you want to stream 1080p video and audio through one connector. So sit back, relax, and experience music, pictures, or videos from your computer, home network, or online. They're quite comfortable, with a luxurious headband, and despite the strong clamping, the soft ear padding cushions your head. It needs its own Canon bp-911 power source, though, so be sure to have an outlet or power strip nearby. Right now, this leaves consumers with a choice between two different styles of devices designed to run Google software. Everything is used to train our dogs in the most realistic way possible. The original Wireless Display technology capped video streams at 720p, as did the first-generation Push2TV "non-HD" receiver.


77. Mr. Astor
asked the Secretary of State for the Colonies whether he will ask for a report on the technical possibilities of the Lowdermilk Plan for the development of Palestine.
§ Colonel Stanley
These proposals are at present the subject of private technical investigation. At a later stage, when they are more fully formulated, I will certainly bear in mind my hon. Friend's suggestion.
§ Mr. Edmund Harvey
Is it not a fact that if the proposals are proved practicable, they will give great benefit to both Arabs and Jews?
Can my right hon. and gallant Friend say when this further investigation will be completed?


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By: Jimmie Sykes
Teyana Taylor brought out the legendary Bobby Brown for a tribute to her mother.
Just a great moment for music and her mother. Teyana Taylor brought out Bobby Brown, who she called the King of R&B. They had a good time performing this and what a treat it was to the fans and her mom.
Teyana also has an album on the way coming early summer. I'm ready to check it out. Watch this performance below via Youtube.

domain: celebrity


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Singer Meghan Trainor says her biggest dream is to start an acting career.
The “All about that bass” hitmaker shared her views on acting career in an interview.
She said: “My biggest dream right now is to start an acting career. I’m going to get an acting coach soon.”
Trainor has already got her foot on the ladder as she was asked to pen new tracks for “The Peanuts Movie”.
She added: “I was terrified and honoured (when I was asked to write the songs). When I told my grandmother, she was pumped! I still have to pinch myself. It’s unbelievable.”
The 22-year-old singer was overcome with emotion when she heard her song play in the cinema for the first time but she managed to keep her excitement contained until she left the venue.
She said: “I was with my family and when I realised my song was coming up, my heart was pounding out of my chest. When it finally happened, I wanted to stand up and dance, but I kept my cool. My brothers and I were dancing in our seats. It was very emotional. I cried when I walked out of the theatre.”


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Taking Back Sunday Tickets
Taking Back Sunday tickets can be ordered safe and secure on Worldticketshop. Our Marketplace allows you to securely buy and sell tickets online for concert tickets, football tickets and theatre tickets. Take advantage of our unique ticket buyer guarantee and TicketCover reimbursement. Your tickets will be sent by registered mail or local delivery. Order your Taking Back Sunday tickets today at Worldticketshop!
Taking Back Sunday Tickets
Exclusive Taking Back Sunday tickets are available here at our 100% safe & secure website! Demand for tickets for the incredibly popular American alternative rock band from Amityville, New York, is incredibly high so secure your seats as soon as possible! The interesting thing about Taking Back Sunday is the fact that they went through many line-up changes, with several members leaving to form other bands. While now fronted by singer Adam Lazzara, the band previously had Antonio Longo and Fred Mascherino assuming vocal duties. Taking Back Sunday are friends with legendary band My Chemical Romance -having played with them several times- and the name of the group is inspired by the words of a song by an obscure band from the Long Island music scene! You will definitely be familiar with their chart-topping single “MakeDamnSure” which they perform at every single Taking Back Sunday concert! Are you dying to go to a show during their upcoming brand new tour? Premium Taking Back Sunday tickets are available at Worldticketshop.com - Your Ticket to Fun!
Taking Back Sunday Tour
The brand new Taking Back Sunday tour is eagerly awaited by diehard fans in the US, the UK and in Europe! If you are a fan of the band from the very beginning, you will know that Taking Back Sunday concert tickets are usually highly sought after. With seminal albums like ‘Tell All Your Friends’, ‘Where You Want to Be’ and ‘Louder Now’ the band quickly managed to reach a mainstream audience fascinated by their unique brand of emo and melodic hardcore. When you are into contemporary American rock, you will definitely have heard hit singles like “A Decade Under the Influence”, “Twenty-Twenty Surgery” and “Liar (It Takes One to Know One”. You may also have caught them during a previous Taking Back Sunday tour when they opened for Blink 182, or when Lazarra accidentally knocked out bassist Matt Rubano with a mic during their gig at London’s Earl’s Court, for example! You may even know the band from their song “What’s It Feel Like to be a Ghost” which featured in the soundtrack to the film Transformers! Are you familiar with all of the above and do just want to proceed to the section above to order your Taking Back Sunday concert tickets? It is all possible here at Worldticketshop.com - Your Ticket to Fun!
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We will send your Taking Back Sunday Alert email immediately once the Taking Back Sunday tickets you're looking for become available, so you'll be the first to know!
* Worldticketshop is a ticket marketplace. The tickets concerned are secondary tickets. Are the tickets you are looking for not listed on our website? Please request the tickets you want.

domain: entertainment


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Toronto City Council adopts public art strategy for Toronto
Toronto City Council adopted a report called Toronto Public Art Strategy 2020-2030: Creativity and Community Everywhere to champion public art in city-building. By implementing this strategy, the City intends to make Toronto a global leader in public art.
The strategy seeks to extend the benefits of public art city-wide and build on public art’s ability to advance broader city-building priorities such as equity and inclusion, environmental resiliency and reconciliation with Indigenous communities.
The City of Toronto’s vision for public art is to promote new and innovative approaches to its creation, to tell stories that build and connect artists and communities to place, and to have artworks in every neighbourhood.
Twenty-one actions are recommended in the strategy to advance public art across Toronto and heighten the impact of the City’s public art programs for residents and visitors. As declared by Mayor Tory last month, the Year of Public Art in 2021 will be the first major new programming initiative related to the strategy.
“Toronto’s arts and culture sector is vibrant, diverse and growing and it is a key component of the economic success of this city,” stated Mayor John Tory in the City’s official press release. “I’m proud that under my leadership, the City has enhanced its commitment to arts and culture and with this new strategy we will ensure that Toronto is more surprising, beautiful, challenging and inspiring in how it is experienced by residents across the city every day.”
More than 1,500 works of public art can be found across Toronto – including works commissioned by the City, its agencies, developers, arts organisations and business improvement areas. The City currently delivers three major public art programs: the City of Toronto Public Art and Monuments Collection, the Percent for Public Art Program and StreetARToronto. Together, these programs have had a major impact on the city’s urban fabric, assembling a collection of public art that, in the number of works alone, is of international significance. This new strategy builds on these strong foundations to enhance their collective impact.
The development of the City’s new public art strategy was guided by an advisory committee of community and cultural leaders, research on best practices in the field, and a comprehensive community and stakeholder consultation process.


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Glanz kei Kyoto station offers 15 accommodations with washers/dryers and complimentary slippers. This accommodation has separate living rooms and includes desks and dining tables. Beds feature down duvets. Accommodation at this 3-star apartment has kitchens with fridges, hobs, microwaves and separate dining areas. Bathrooms include a separate bath and shower with a deep soaking bath, bidets, complimentary toiletries and hairdryers.
Guests can surf the web using complimentary wireless Internet access. 50-inch LCD televisions come with digital channels and Netflix. Housekeeping is provided on a weekly basis.

domain: travel


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Statement of Licensing Policy
The Licensing (Scotland) Act 2005 requires Licensing Boards to prepare and publish a statement of its licensing policy every three years. East Ayrshire Licensing Board is now consulting on the terms of its revised Statement of Policy.
In terms of Section 7 of the Act, the Board are required to include a statement as to the extent that the Board considers there to be over provision of licensed premises or licensed premises of a particular description in any locality within the Board’s area.
On the basis of the information provided by various local agencies and having regard to the Board’s own knowledge, the Board determined on a preliminary basis that there is no over provision either (a) of licensed premises or (b) of licensed premises of a particular description in any locality within East Ayrshire and any new applications will continue to be dealt with on their individual merits.
Responses to the Statement of Policy should be submitted no later than 2 September 2013.
How to respond
Responses should be sent to the Clerk to the Licensing Board at the undernoted address or by e-mail.

domain: law


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Pennsylvania Motorcycle Accident Lawyers
A recent article in The Morning Call highlighted a new effort in Pennsylvania to increase motorcycle safety awareness. In an effort to reduce the number of Pennsylvania motorcycle accidents and fatalities, PennDOT has created a sobering online documentary called “Live Free Ride Alive.” This short documentary includes interviews with several Pennsylvania motorcyclists who share why they love riding in spite of the losses some of them have suffered and the risks. In addition, this website also features safety tips, crash statistics, and information about motorcycle training programs. Pennsylvania motorcyclists are encouraged to post or send YouTube videos with their own motorcycle stories on the Live Free Ride Alive website. Check it out.
The timing of Pennsylvania’s motorcycle accident prevention campaign is good in light of these recent PA motorcycle accidents:
Anne Beiler, the founder Auntie Anne’s national pretzel franchise, was injured in a motorcycle accident in Gap, Pennsylvania on Saturday July 24. According to an article in the Philadelphia Inquirer, Beiler’s motorcycle went down after she ran over an oil spot on the road. Her injuries included a concussion, a broken collarbone, and broken rib. Luckily, Beiler was wearing a helmet at the time of the Pennsylvania motorcycle accident.
While Auntie Anne may have escaped her motorcycle accident with relatively minor injuries, another recent Pennsylvania motorcycle accident had a much more tragic ending. Back on June 27, five Harley riders died and another was critically injured in a horrible Lancaster County Pennsylvania motorcycle accident. A United Press International article states that the six bikers were riding on three bikes when they all crashed into a van on northbound Route 72. All three Harleys hit different sides of the van. Five of the victims died at the scene and the surviving motorcyclist was transported to a nearby hospital in critical condition. Some of the victims were still wearing their helmets and other helmets were found around the accident scene.
If you or someone you love is injured in a Pennsylvania motorcycling accident, it is important to find a Pennsylvania motorcycle accident attorney who understands the intricacies associated with motorcycle accidents.
Contact 1-800-4-BIKERS today to get the legal representation you deserve in Pennsylvania.
WE RIDE—WE CARE—WE WINPowered by Qumana


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The Chicago Bears took four defensive pre-snap penalties in the first half against the Philadelphia Eagles on Sunday, and they believe they were illegally baited into it.
Bears pass-rusher Khalil Mack accused Eagles center Jason Kelce of turning the ball before the snap, goading the Bears into jumping offside. If a center is adjudged to move the ball before the snap, he should be called for a false start.
“You see the bull—- Kelce was kinda doing with the ball, just moving it a little bit,” Mack said, via Jason Lieser of the Chicago Sun-Times. “But even then, you can’t really make no excuses. That’s not the type of group we have. We’ve still gotta get there, regardless of what it is and what that was. All those offside penalties, it hurt us.”
Coach Matt Nagy refused to criticize his penalized players after the game and suggested that he agreed with their criticism.
“I know what it was,” Nagy said. “There was some stuff to that. I’m not gonna get into that.”
The Bears had reason to be angry if Kelce was doing what they’re accusing him of, but the defense played fairly well overall. And Kelce’s actions, accurate or not, had nothing to do with how awful the Bears’ offense was in the first half.
Jason Kelce cleared concussion protocol despite showing troubling signs beforehand.
The Philadelphia Eagles center was apparently dazed after the team gave up a sack on a third down in the second quarter of their game Sunday night against the Atlanta Falcons. Kelce later was shown on the Eagles’ sideline while his team kicked a field goal on fourth down. NBC announcer Al Michaels said that Kelce had gone to the wrong sideline initially before finding his way to Philly’s sideline.
About 15 minutes after mentioning that, Michaels said Kelce had cleared concussion protocol and was ready to return.
The Eagles had multiple injuries in the game. In addition to Kelce’s concussion check, Dallas Goedert, Alshon Jeffery, and DeSean Jackson all had injuries that left them questionable to return. Carson Wentz also exited before halftime after taking a big hit.
A report about Jason Kelce retiring after the season is said to be inaccurate.
Early Saturday, ESPN 610 radio host Al Thompson said Kelce would “likely retire” at the end of this season.
A non NFL source with ties to his family informs that at the end of this playoff run, Eagles Pro Center Jason Kelce will likely retire. Since the 2011 sixth round pic out of Cincinnati is healthy, it's unknown if it's for a job in the media or another opportunity. Kelce is 31. pic.twitter.com/sncqh5oX2y
— Al Thompson (@thompsonIII) January 12, 2019
Eagles reporter Eliot Shorr-Parks shot down that report, saying he has heard it is “inaccurate.”
The report that Jason Kelce is "likely" to retire at the end of this season is inaccurate, per sources. #Eagles
— Eliot Shorr-Parks (@EliotShorrParks) January 12, 2019
Kelce, 31, has played for the Eagles his entire career, beginning in 2011. He has made three Pro Bowls and been first-team All-Pro once. He has dealt with an elbow injury this season and been the subject of trade rumors. Kelce is signed through 2020.
One prominent Philadelphia Eagle is wasting no time stirring up the team’s rivalry with the Dallas Cowboys ahead of their first meeting of the season.
Philadelphia center Jason Kelce did not mince words about the Cowboys, stating that he didn’t like the organization or the fans very much at all.
“There’s certainly a rivalry there, we play them twice a year,” Kelce told the 94WIP Morning Show on Wednesday, via Angelo Cataldi of the station’s official website. “I would say mostly I just don’t think a lot of players, in particular me, just don’t really like the franchise, the organization, what is stands for—what it’s always stood for. This goes back to the lockout when they were getting replacement players, how outspoken the Dallas Cowboys franchise was in ending that. I’ve just never really appreciated what the organization—and what its fans really stood for. A lot of fair weather people from across the country that just kind of fell in love because they’re winners instead of having any type of emotional connection to the team whatsoever.”
Kelce, who is not shy about saying what he thinks, will probably find a lot of agreement from some people about the state of the Cowboys. And there’s nothing wrong with fanning the flames of a rivalry ahead of Sunday’s kickoff.
No one — and we mean no one — was more fired up when the Philadelphia Eagles held their championship parade on Thursday than Jason Kelce, and the veteran offensive lineman used the platform to unload on the media in a way you have probably never heard before.
NFL GM turned analyst Michael Lombardi caught the worst of it by far. Back in September, Lombardi criticized Pederson for being “(maybe) less qualified to coach an NFL team than anyone I’ve seen in my 30-plus years in the NFL.” The Eagles clearly did not forget it, nor did they forget any of the other ways the media doubted them during an improbable run that ended with a win over the New England Patriots in Super Bowl LII.
Kelce spoke for the entire team in crucifying the naysayers, and he did it while wearing one of the most outlandish outfits you will ever see. You’ll want to watch the entire thing:
— Barstool Sports (@barstoolsports) February 8, 2018
“This past offseason, some clown named Mike Lombardi told (Pederson) that he was the least qualified head coach in the NFL … a man who went for it on fourth down in the Super Bowl with a trick play,” Kelce screamed. “He wasn’t playing just to go mediocre, he’s playing for a Super Bowl!”
If you remember, Lombardi was partially responsible for some talk about an issue among the Eagles’ coaches early in the season. So much for that.
Overall, Lombardi had a very tough week. Even before Kelce blasted him, the former scout and executive was ripped to shreds for doubting Pro Football Talk’s report that said Josh McDaniels was having second thoughts about becoming the head coach of the Indianapolis Colts.
It's so hard for people to admit they were wrong. Mike Lombardi still won't even admit he was wrong about saying Josh McDaniels had no hesitation at all about taking the Colts job. Someone points out to him that he was wrong and he says, "Hey, he took the job." pic.twitter.com/x2k4v6pnFX
— Michael David Smith (@MichaelDavSmith) February 7, 2018
Analysts who rely on delivering hot takes always run the risk of looking bad. For Lombardi, the breeze from the whiffs can be felt from miles away.
The Philadelphia Eagles’ running game took a major step back in 2015, and a lot of the blame for that has been placed on Chip Kelly. Veteran offensive lineman Jason Kelce does not think that assessment is fair.
Appearing on 94.1 WIP on Monday, Kelce said the dip in rushing production last season was a result offensive linemen — including himself — playing poorly, ineffective scheming and the guy who was carrying the ball.
“I don’t think necessarily we had the best back that we had a few years ago either,” Kelce said, accoridng to Jimmy Kempski of PhillyVoice.com.
That was almost certainly a shot at DeMarco Murray, who never got it going with the Eagles after they signed him to a five-year, $42 million contract last offseason. Following his breakout 1,845-yard season with the Dallas Cowboys, Murray managed just 702 on 193 attempts in Philly.
Before Murray joined the Eagles, LeSean McCoy rushed for 1,319 yards in 2015. He averaged 5.1 yards per carry in 2014, finishing with a whopping 1,607 yards. For some reason, Kelly didn’t seem to like McCoy and traded him to the Buffalo Bills, opting to sign Murray instead.
For what it’s worth, Kelce is about as unbiased of an opinion as you will get from the Kelly era in Philadelphia. He actually defended the coach’s methods earlier this offseason and criticized some of his teammates for complaining about them. Kelly made plenty of mistakes, but there were indications Murray was not well-liked in the locker room. Perhaps Kelce’s remark was a reflection of that.
A Philadelphia radio host raised some eyebrows on Tuesday by comparing a white football player to a “house negro.”
Josh Innes, who hosts an afternoon show on WIP in Philly, was talking with former Eagles defensive tackle Hollis Thomas prior to airing Doug Pederson’s introductory press conference on the show. According to Crossing Broad, Thomas mentioned how center Jason Kelce was already at the press conference.
Innes then joked that Kelce was a big rear-end smoocher, while Thomas said he understood that Kelce was trying to show support for the coach because he wants to protect his job. That’s when Innes began comparing Kelce to a house negro.
“Here’s the thing though, right, it’s like this. Let me find a good comparison here. I was watching Malcolm X yesterday, I was in the airport in Memphis watching Malcolm X, and there was a scene where Denzel’s doing the whole thing about the slave and the house negro? Right? And like, the house negro is the guy who’s gonna tell you like, oh he gets to live in the big house with the boss. And every time he refers to something that happens in the house it’s ‘our house’ and ‘we’ and everything like that. And then there’s the actual slave that isn’t the house negro that’s just trying to run away. Essentially what you’re getting here is Jason Kelce is the house negro is what I’m trying to convey to you.”
If you call Kelce a rear-end smoocher or suck-up, that’s fine and we understand the message Innes is trying to convey. It’s just odd and questionable to bring in slavery analogies when you know that is a touchy subject.
Kelce later responded on Twitter, saying he’ll take the comparison.
— Jason Kelce (@Jkelce) January 20, 2016
Innes later apologized, saying his intention was not to offend and that his reference came out poorly. He also called himself “stupid.”
Innes should probably learn it’s best not to go down that road. It’s an especially awkward comparison knowing that Kelce was with Riley Cooper the night of the infamous concert.


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Argos Home Pair of Touch Table Lamps - Chrome and Red Click & Collect
Light up your room with this pair of contemporary red and chrome touch table lamps. Perfect for bedside tables, or bookmarking a long sideboard, these clever lights are operated by a simple tap of your hand. With 3 light settings, you can choose the brightness to suit the mood. Just make sure you use dimmable SES bulbs. Blending shiny metallics with soft fabric shades, they add a pop of on-trend colour to any room. See the rest of our lighting collection for matching styles and designs.
Overall size H25.5, W16, D16cm, .
Shade size H16, D16cm.
Diameter of base 11.5cm.
Cord length 1.2m.
Bulbs required 2 x golfball E14 small edison screw eco halogen bulb(s) (not included).
Recommended maximum wattage: 40 watts.
Touch sensor - 4 stage touch control.
IP rating 20 - not suitable for bathroom use.
Product is mains powered.
Manufacturer's 2 Year (1 year fabric) guarantee.

domain: design


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Unspayed Females Accepted, Neutered Males Only
No Females in Heat
Our dog, henry, had a great time with Jordan. He was well exercised and happy when we picked him up. Jordan was also very responsive through the whole process. Thank you!
Large fenced in yard!
Need a place for your pet to stay and play while you're away? Look no further! We have two Cavachons and a German Shorthaired Pointer, all are very friendly and playful. We have a fenced in back yard and plenty of toys if you allow! We can take them to the dog park, or on walks around town. We can administer medication, trim nails, and bathe. A dog meet and greet is preferred, but ...
What Jordan would like to know about your dog
Is he/she aggressive towards other people or dogs, does he/she have any anxiety or issues that will need extra care?

domain: pet


SoMat eDAQlite Battery Layer
The SoMat eDAQlite Battery Layer (ELBAT-2) is located below the eDAQlite in a machined aluminum enclosure. It attaches with four 8-32 screws to the base plate of the eDAQlite, replacing the rubber feet. The feet can be relocated to the battery layer for mounting purposes. A short cable, with the eDAQ D-Sub power connector, connects to the eDAQlite and is also utilized for charging purposes.
The battery is a lithium polymer (LiPo) pack with a capacity of 4000 mAh. Depending on the eDAQlite configuration, it can support a system for more than 10 hours. Since every eDAQlite configuration is unique; measuring the current draw, or using guidelines for power estimates, will determine the performance on your system.
Not Available in EU Countries
Size: 5.625”W x 7.875”L x 1.0”H (14.3cm W x 20cm L x 2.54cm H)
Weight: 3.0 lbs (1.37kg)
Temperature: 0° to 140° F
Connectors: D-Sub Power Connector
Power Supply: 14.8 – 12V
Volts Capacity: 4000 mAh
Charge/Discharge Cycles: 300+
Re-Charge Rate: About 1 hour
(1) Charging System (ELBAT-CHARGER)
Please enter your email address.
Candid data sheets: We keep our promises.
Precision in series: This also applies to the accuracy of the values specified in our data sheets. Ideal conditions can often be theoretically attained based on the values given, but our data sheets focus on realistic standard assumptions - such as those likely to be encountered in your application. Therefore, please consider this when comparing our data sheets with those of other manufacturers.
Cables and Accessories
eDAQ-lite Replacement Battery
The SoMat eDAQ-lite Replacement Battery (ELBAT-RB) is the replacement battery for the SoMat eDAQ-lite Battery Layer (ELBAT).
eDAQ-lite Replacement Charger
The SoMat eDAQ-lite Replacement Charger is the replacement battery charger for the SoMat eDAQ-lite Battery Layer (ELBAT). Not Available in EU Countries
Product No.: ELBAT-CHARGER
E-AC/15 – 15-Volt Power Supply
The E-AC/15 is a high-quality 15 volt DC power supply that provides power to an eDAQ or eDAQlite from a standard 120/240 volt supply.


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If you haven't already read her book I would highly recommend it. My review is here
I’m going to be perfectly candid and admit that this whole experience has been quite surreal. I feel a but as if I might be using that word far too often these days, but I don’t know quite how else to describe it. It’s surreal to know that you’ve written a book––from start to finish––and that people are actually willing to read it. It’s surreal to know that it’s been published, that it’s out there for the whole world to see and experience. It’s surreal to realize that a goal and a dream have finally come to fruition. Maybe one of these days, I’ll have another word to pull out of my hat, but right now, this is all I have.
That, and honored, simply for the fact that I’m grateful that someone saw beauty in the story I told and that they took the risk and the time to put it out there. You reach a point in this whole process of book writing that one more letter or email from an agent couldn’t possibly be anything other than a rejection, a one-lined, canned assassination of your work. You dismiss them before they’ve even been opened, so accustomed to that rejection are you that you’ve grown past the point of allowing yourself to hope that this one might actually be THE ONE!
I think, for any author who truly connects with their work, that writing a book––even if it’s non-fiction––is extremely emotional, so this whole process is actually one that puts them in a vulnerable position. The characters you create are part of you, even if it’s only in some small way. I think they all represent different facets of your personality and your history. Their story is your story, reimagined and divided into these people who live only on the page. You have to be able to imagine them and breathe dimension and life into them, so as you write, you feel. It’s taxing, sometimes, the way that writing some of the characters effects your mood. If they hurt, you hurt. If they’re afraid or overwhelmed or joyous, you feel all of those things. You have to. There’s no other choice––because if you can’t feel it, your readers won’t be able to, either.
By the same token, for a character to be more real and relatable, you have to let them lead. If it doesn’t seem to happen naturally, the writing suffers and the characters seem too contrived. Real people and real life are unpredictable, so even when you’re the writer, I think it’s important to be surprised by some of the things your characters do. There must be a certain concept in place, yes––but it shouldn’t be so rigid that they never stray from the straight line of “the plan.” You have to let them inspire you and surprise you; you have to be interested in knowing them more––otherwise, your readers will never experience any of that, either.
I think it’s that true connection that makes a book successful. No one wants to read a story that feels flat and formulaic. No one wants to be able to predict, step-by-step, the outcome from the very first page to the last. Life isn’t like that, so neither should a book be like that.
These were all things I learned as I wrote Coming Home to You. I found myself lost in the lives of my characters, surprised and angered and excited at things as they unfolded. There were days of exhaustive grief as I wrote portions of it, days when I felt some unexplainable sense of hope. My emotions poured out through my fingers as I typed creating a world that seemed so real to me that, as I neared the end of the story, I began to miss.
I hope that the book is one that readers will love and embrace whole heartedly. That they will see bits of themselves in the characters and that they will realize the ultimate message of the story––that unimaginable gifts can come from grief, and that life is full of purpose.


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Emerging Market Opportunities
What are your options for investing in emerging markets?
Have A Question About This Topic?
The average retirement lasts for 18 years, with many lasting even longer. Will you fill your post-retirement days with purpose?
Exchange-traded funds have some things in common with mutual funds, but there are differences, too.
Things to consider before retirement.

domain: economics


DENSITY OF SEMI-SOLID BITUMOUS MATERIALS
This test method covers the determination of the specific gravity and density of semi-solid bituminous materials, asphalt cements, and soft tar pitches by use of a pycnometer.
REF 20847 Pycnometer A – Hubbard type, wide mouth form used for very viscous liquids and solids
REF 24624 Pycnometer B – Wide mouth form, used for very viscous liquids and solids
REF 23229 Pycnometer C – “warden” form, specific gravity bottle for volatile products
REF 23230 Pycnometer D – Gay-Lussac type, suitable for non-volatile liquids except those of high viscosity


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Introduction to Senate Bill 961
California’s commitment to road safety takes a pioneering leap with the introduction of Senate Bill 961. This groundbreaking legislation, proposed by State Senator Scott Wiener, aims to revolutionize vehicle speed control. By mandating the installation of speed governors in new cars and trucks sold from the model year 2027, California sets a precedent in traffic safety management.
Key Features of the Speed Governor Technology
The core functionality of these speed governors is to limit a vehicle’s speed to no more than 10 mph above the posted limit. This cutting-edge technology integrates seamlessly with existing vehicle systems, ensuring a harmonious blend of safety and performance.
Advantages of Implementing Speed Governors
Enhancing Road Safety
A significant reduction in traffic fatalities and injuries is the foremost advantage. Speed governors address the root cause of many accidents, offering a practical solution to a persistent problem.
Promoting Equitable Road Usage
The implementation of speed governors benefits all road users. Pedestrians, cyclists, and motorists alike can enjoy a safer travel environment, fostering a more inclusive and responsible road culture.
Streamlining Traffic Flow
Uniform speed adherence potentially eases traffic congestion. This can lead to smoother traffic, less idling, and a more pleasant driving experience.
Addressing Challenges and Concerns
Balancing Individual Freedom and Collective Safety
The proposal carefully navigates the delicate balance between personal liberty and public welfare. Ensuring that the technology respects individual rights while serving the greater good is paramount.
Ensuring Technological Reliability
The accuracy and dependability of speed governors are crucial. Rigorous testing and quality assurance are necessary to build public trust and acceptance.
Exemption and Enforcement Policies
Crafting clear guidelines for exemptions, especially for emergency vehicles, is essential. Moreover, enforcing compliance in a fair and effective manner is a key consideration.
Cost Implications and Accessibility
The economic impact on vehicle pricing is a significant aspect. Ensuring that this safety feature remains affordable and accessible is a priority.
Current Legislative Status and Public Discourse
Navigating the Legislative Process
Senate Bill 961 is at an early legislative stage, with a path full of discussions and revisions ahead. Its progress is a subject of keen interest to various stakeholders.
Diverse Opinions and Debates
The bill has garnered attention from safety advocates, automotive industry experts, and civil liberties groups. These differing viewpoints contribute to a rich and constructive debate, shaping the bill’s future.
Conclusion: A Step Towards Safer Roads
California’s proposal to implement speed governors is a bold and innovative step. It reflects a commitment to enhanced road safety, technological advancement, and responsible governance. As the bill moves through the legislative process, its potential to set a new standard in traffic safety is undeniable.
By embracing this visionary approach, California not only addresses a crucial safety concern but also positions itself as a leader in automotive safety innovation. The implications of Senate Bill 961 extend beyond state boundaries, offering a template for others to follow in the pursuit of safer roads.


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The Market Square occupies the space opposite the City Market Building on Campbell Avenue in the heart of City Market District of Downtown Roanoke. The open air area was authorized as a City project in 1884, followed by construction of the centerpiece Market Building in 1886. The surrounding space has since been occupied by a mix of fresh fruits and vegetables, crafts and flower vendors, called “hucksters” in the early days. Roughly one hundred years later the area gained the distinction of being named to the National Register of Historic Places, and, remains the oldest continuously operated open air market in the Commonwealth of Virginia.
Not only a marketplace for items to buy, the City Market District also is a place for festivals year round, including the weekly “Dickens of a Christmas” held on Friday nights during December in the runup to Christmas.
Other sites within the bounds of the District that are among our Roanoke Collection include: Market Building, Fire Station No.1, the H&C Coffee and Dr.Pepper neon signs.
Solid Brass Christmas Ornament: Brushed Finish. Includes ribbon as shown. First produced in 2020.
Dimensions: 1.1” height x 2 ½” width

domain: history


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NSF Launches 229 China GMP for Nutritional Supplements
Shanghai, China – NSF, a leading public health and safety organization, today launched NSF 229 China GMP Registration for Nutritional Supplements in China. NSF 229 China GMP is a new bespoke local program created to meet the demands of the large nutritional supplements manufacturing industry in China and help these manufacturers better adapt to the needs of the Chinese market.
The distinctive feature of the NSF 229 China GMP registration program is that it incorporates audit requirements based on Chinese manufacturing and product safety standards, combined with the U.S. GMP and industry best practices.
"Through one-stop local service, NSF can provide manufacturers with faster response and more flexible services," said Ceci Li, Senior Manager of Global Certification, Health Science Cert Program Office, ”Obtaining NSF 229 China GMP registration helps companies gain the trust of consumers. We look forward to the participation of relevant companies to facilitate standardized production, management and operation among the industry.”
NSF 229 China GMP consists of an audit of nutritional supplement manufacturers’ facilities selling their products in China. The audit covers manufacturing, packaging, and/or warehousing and distribution of nutritional supplements and nutritional ingredients companies. Registered companies can obtain a bilingual Chinese-English certificate with stronger international applicability. NSF 229 China GMP registration can also be bundled with other NSF certifications to reduce the audit time and costs. In addition, choosing to work with NSF GMP-registered suppliers provides a faster pathway for finished-product manufacturers to earn NSF product certification (NSF/ANSI 173, NSF 229 and NSF Certified for Sport®) with reduced time and costs for testing.
NSF Health Sciences offers GMP registration/certification and product certification services in China, including dietary ingredient GMP registration, NSF/ANSI 455 GMP certification for dietary supplements/cosmetics/OTC, NSF/ANSI 173 product certification for dietary supplements and dietary ingredients, Certified for Sport® product certification, and NSF 229 functional food product certification.

domain: food


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Well-known health freak, Gwyneth Paltrow, gave up her strict diet whilst pregnant with Apple. The actress gave in to her grilled cheese sandwich and pizza cravings. Her pregnancy learnings? "What I learned during my pregnancy is that there is a real lack of Mexican food in London and the pizzas are too small."
Photo by Getty Images Aug 23, 2012


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HCT500X corrosion resistance
Translate this page5.3 5.3 steel quality 5.3.1 5.3.1 Steel sheet surface shall be of good 4 phosphatization,coating,and corrosion resistance.The classification of surface quality shall be as given in Table 4.What is Corrosion Resistance? - Definition from CorrosionpediaApr 12,2013 HCT500X corrosion resistance#0183;Corrosion resistance is the capacity to hold the binding energy of a metal and withstand the deterioration and chemical breakdown that would otherwise occur when the material is exposed to such an environment.Corrosionpedia explains Corrosion Resistance.Walzwerke Einsal Corrosion resistanceDetermination of corrosion resistance of stainless steels in hydrosulphide media in the context of DIN EN ISO 15156 / NACE.A steel is considered as resistant if PREN 40.PREN is sufficient for steels with Mo 1,5 wt.-%.
Some results are removed in response to a notice of local law requirement.For more information,please see here.Previous123456NextCorrosion Resistant Concrete Screw MSCDirect
Phillips drive types have a cross-shaped slot and are used with Phillips drivers.Stainless steel is a strong,corrosion-resistant alloy with excellent resistance to heat.It is used in high-stress,outdoor and corrosive applications.Some results are removed in response to a notice of local law requirement.For more information,please see here.12345NextCorrosion Resistance Table of Stainless Steel Nickel Monel Corrosion Resistance Table of Stainless Steel Nickel Monel Inconel.The table below indicates the approximate corrosion resistance of selected corrosion resistant metals to a range of common chemicals.This is collated information from various sources but is of limited quality.For good quality information please consult reputable reference Some results are removed in response to a notice of local law requirement.For more information,please see here.
HCT500X Grade as per DIN EN Table B.5 Correspondence of codes between standards for multiphase steels FB780 FB590 FB450 MS1200 CP800 CP980 CP800 TRIP800 TRIP700 DP600 DP980HY DP980 DP780 DP600 DP500 Trivial name Page 31 VW 50065 2013-07 Zinc-magnesium (ZM) Aluminum-silicon (AS,hot-dip aluminized) Galvannealed (GA) ZM70 ZM90 ZM120 ZM40/40 People also askWhat is corrosion resistance table?What is corrosion resistance table?Corrosion Corrosion Resistance Table of Stainless Steel Nickel Monel Iconel The table below indicates the approximate corrosion resistanceof selected corrosion resistantmetals to a range of common chemicals.This is collated information from various sources but is of limited quality.Corrosion Resistance Table of Stainless Steel Nickel Monel Metals and Corrosion Resistance - Engineering ToolBoxCommon metals and their corrosion resistance to aggressive fluids like acids,bases and more.Engineering ToolBox - Resources,Tools and Basic Information for Engineering and Design of Technical Applications! - search is the most efficient way to navigate the Engineering ToolBox!
Oct 12,2015 HCT500X corrosion resistance#0183;5/22/2018 Hot Dip Galvanized Sheet 1/526X.Hot-dip galvanized sheetEMW delivery range Coils Slit strip Cut-to-size sheetThicknesses from 0.30 4.50 mm from 0.30 4.50 mm fromHigh-Performance Alloys for Resistance to Aqueousenvironments,nickel is more corrosion resistant than iron,but not as resistantas copper.Alloying with chromium provides resistance to oxidation thus providing a broad spectrum of alloys for optimum corrosion resistance in both reducing and oxidizing environments.Nickel-based alloys have a higher tolerance for alloying elements inEffect of Cu on the corrosion resistance and The NiCoCrMo alloys corrosion resistance was not simply increasing with copper addition increasing from 0 to 4 mass%.The X-ray photoelectron spectroscopy etching analysis was also conducted to illustrate the fraction of Cu at various depths in the passive film,and the results reveal that a maximum limit on Cu content
HCT500X corrosion resistance#0183;The crevice corrosion shown above happened when an aerospace alloy (titanium - 6 aluminum - 4 vanadium) was used instead of a more corrosion-resistant grade of titanium.Special alloying additions are added to titanium to make alloys which are crevice corrosion resistant even at elevated temperatures.Corrosion resistance of duplex stainless steelsThe prevention of corrosion is assumed to be suitable if the attack rate is lower than 0.1 mm per year.Duplex steel grades contain large magnitude of chromium that enables them to offer good corrosion resistance in the different environments.Sulfuric acid.Following diagram shows the corrosion resistance in sulfuric acid.Corrosion resistance classes (CRC) - TOBSTEEL GmbHCalculating resistance classes.DIN EN1993-1-4:2015-10/Eurocode 3 describes how a corrosion resistance factor (CRF) is determined,which,in turn,determines the corrosion resistance class (CRC).The CRF depends on the corrosiveness of the respective environment and can be calculated using the following formula:
Corrosion,wearing away due to chemical reactions,mainly oxidation (see oxidation-reduction,oxide).It occurs whenever a gas or liquid chemically attacks an exposed surface,often a metal,and is accelerated by warm temperatures and by acids and salts.Normally,corrosion products (e.g.,rust,Corrosion Resistant Coatings for Various Types of Corrosion2 days ago HCT500X corrosion resistance#0183;A brief discussion of corrosion and corrosion-resistant coatings.Image credit GaViAl/Shutterstock.It is common for high-performance structural components and process equipment to experience some form of corrosion regardless of what type of material is used and corrosion-resistant coatings can increase the lifespan of a part,as well as reduce maintenance andCorrosion Resistance|Wet Corrosion|High Temperature The Pitting Resistance Equivalent (PRE),often also given as PREN to indicate the influence of nitrogen in the steel,can be used in order to rank and compare the resistance of different stainless steels in terms of their resistance to pitting corrosion.It takes into account the effect of
The Pitting Resistance Equivalent (PRE),often also given as PREN to indicate the influence of nitrogen in the steel,can be used in order to rank and compare the resistance of different stainless steels in terms of their resistance to pitting corrosion.It takes into account the effect ofCorrosion Resistance of Stainless SteelsCorrosion resistance of stainless steels Corrosion in concrete (corrosion problems are not limited to outside surfaces !) Stainless steel provides both strength and corrosion resistance inside the concrete,providing a long,maintenance-free service life of the structure.Corrosion of unprotected carbon steel occurs even inside reinforcedCorrosion Resistance Testing of Stainless Knife Steels Oct 14,2019 HCT500X corrosion resistance#0183;The corrosion resistance experiments reported were either a mass loss after a set amount of time in acid or a voltage measurement of pitting resistance in salt water.Neither was a measure of rust formation itself.It may be that one of these tests correlates well with rust formation but I dont know which of them it would be.
Corrosion Resistance Table of Stainless Steel Nickel Monel Inconel.The table below indicates the approximate corrosion resistance of selected corrosion resistant metals to a range of common chemicals.This is collated information from various sources but is of limited quality.For good quality information please consult reputable reference Corrosion Resistance Guide - PSGcorrosion resistance guide chemicals metals plastics elastomers cast iron cast steel 304 stainless 316 stainless alloy 20 alloy b alloy c pvc cpvc polyethylene polypropylene pvdf (kynar) acrylic nylon ptfe viton epdm hypalon (csm) neoprene borax (sodium borate) a - a a a a a a a a a a a a a a a a a Corrosion Materials Worldwide Corrosion Resistant Alloy Corrosion Materials is a global distributor and manufacturer of corrosion resistant alloy products.We have been supplying corrosion resistant alloys for more than 50 years and have developed the resources,skills and inventory to satisfy the demanding needs of a multitude of markets.
Cited by 310Publish Year 2015Author Wanqiang Xu,Wanqiang Xu,Nick Birbilis,Nick Birbilis,Gang Sha,Yu Wang,John E.Daniels,Yang XiaPrecisely what customers want.
colofer HCT500X corrosion resistance#174;,highly resistant and economical,offering a broad range of colours adapted to various applica-tions,such as anti-fingerprint qualities.anti-corrosion primer for unique corrosion pro-tection.with excellent cold forming properties,and perfect-ly suitable for welding,cutting and blanking.COLd rOLLed sTrIPs And sHeeTs eLeCTrICAL sTrIPsChemical Composition And Corrosion Resistance OfNov 20,2020 HCT500X corrosion resistance#0183;Special super duplex stainless steel is designed to solve the lack of local corrosion resistance and strength of super duplex stainless steel heat-resistant chloride.It came out after 2000.The PRE value of S32707 stainless steel can be as high as 49.It is high in nitrogen,molybdenum,chromium and duplex.Aluminum Oxidation Is Aluminum Corrosion-Resistant But,its corrosion resistance is fairly low,so youll often see it with either an anodized surface (see below) or with Alclad.Alloy 7075 Of all of the aluminum alloys,7075 is one of the highest strength alloys.Like 2024,it has an excellent ratio of strength to weight and is
Ductility and corrosion resistance are generally inversely correlated with strength,making it difficult to optimize all three simultaneously.Here we design an ultralow density (1.4 g cm(-3)) Mg-Li-based alloy that is strong,ductile,and more corrosion resistant than Mg-based alloys reported so far. results for this questionWhat is intrinsic corrosion resistance?What is intrinsic corrosion resistance?Besides intrinsic corrosion resistance,a metal's resistance to corrosion can be increased by applying different methods such as cathodic protection,coating,painting and applying a corrosion inhibitor.There are no materials that are resistant to all corrosion in all environments.Materials must be matched to the environment they will experience.What is Corrosion Resistance? - Definition from Corrosionpedia results for this questionWhat is corrosion resistant coating?What is corrosion resistant coating?Corrosion Resistant Coatings.Corrosion resistant coatings for metal vary depending on the kind metal involved and the kind of corrosion prevention needed.To prevent galvanic corrosion in iron and steel alloys,coatings made from zinc and aluminum are helpful.Corrosion Resistant Coatings for Various Types of Corrosion
results for this questionIs galvanic corrosion electrochemical?Is galvanic corrosion electrochemical?When metal,specifically steel,is exposed to water,the surface is oxidized and a thin layer of rust appears.Like galvanic corrosion,general corrosion is also electrochemical.In order to prevent oxidation,a preventative coating must interfere with the reaction.Corrosion Resistant Coatings for Various Types of Corrosion results for this questionFeedback - TAGAL
TAGAL has a wide range of products and almost covers the whole series of advanced auto sheets,including Low Carbon Steels,Low Alloy High-strength Steels,Bake Hardening Steels,Dual Phase Steels,Hot Forming Steels,and etc.to meet the following requirements of the customers: HCT500X corrosion resistance#199;olakolu Metalurji - Productshct500x (dp 500) 83500 high strength dual phase wheel steels suitable for cold forming and spinning din en 10338-2010 hdt580x (dp 600) 83600 hot rolled high strength dual phase steel suitable for cold forming atmosphere corrosion resistant steels din en 10025 part 5-2004 s235j0w 58235 atmosphere corrosion resistant steels din en 10025

domain: chemistry


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Alan Greenblatt has been covering politics and government in Washington and around the country for 20 years. He came to NPR as a digital reporter in 2010, writing about a wide range of topics, including elections, housing economics, natural disasters and same-sex marriage.
He was previously a reporter with Governing, a magazine that covers state and local government issues. Alan wrote about education, budgets, economic development and legislative behavior, among other topics. He is the coauthor, with Kevin Smith, of Governing States and Localities, a college-level textbook that is now in its fourth edition.