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By incorporating the drug target interaction data and sensitivities of training drugs with genomic signatures, we were able to achieve a cor relation coefficient of 0. 79 for prediction of Erlotinib sensi tivity using 10 fold cross validation. The result illustrates the fundamental concept of the importance of drug target interaction and functional selleck chemicals data under which we develop the sensitivity prediction method presented in this paper. By developing a framework around the functional and tar get information extracted from the primary tumor drug screen performed by our collaborators, we seek to develop a cohesive approach to sensitivity prediction and com bination therapy design. This necessitates the generation of the tumor pathway structure for individual patients to decide on the target inhibitors for therapy based on the personalized patient pathways.
We envision that the overall schematic of the design of personalized pathways and personalized therapy will be similar to the workflow shown in Figure 1. The explanations of the various steps in the design process are as follows, The primary contributions of this paper are, methods for extraction of numerically relevant drug targets from single run drug screens, design of the personalized TIM circuit based on drug perturbation data, algo rithms for sensitivity prediction of a new drug or drug cocktail, validation over canine osteosarcoma primary tumors and pathway flow inference using sequen tial protein expression measurements. The scope of the present article is concentrated around steps B, C and D of Figure 1.
The perturbation data required for our proposed method originates from a drug screen consisting of 60 small molecule inhibitors with quantified kinase interac tion behaviors. This drug screen, denoted Drug Screen Version 1. 0, consists of two sets of data, The first set is the experimentally generated drug sensitivities provided as 50% inhibitory concentration values. The IC50 values denote the amount of a drug required to reduce the population of cancerous cells in vitro by half. The sen sitivity values are expected to change during each new cell line tumor culture experiment. The generation of the sensitivities in step C can be done within 72 hours of ini tial biopsy using drug sensitivity assays which is a period of limited cell divisions for most primary cultures.
Thus, the estimated personalized maps may be closer to real time circuits in cancer cells akin to the signaling found in an untreated patient within a day or two after biopsy, and not the evolving Brefeldin_A consensus pattern of signaling for grow ing and dividing tumor cells as subpopulations emerge with increased fitness in vitro. In addition, the drug screen contains experimentally derived half maximal con centration values for the interaction of each drug and each kinase target.
The top three pathways in sellekchem T3 CMHDF cells are development, cytos keleton remodeling and immune response. The top three pathways in T3 MEF cells are cell adhesion, cytoskeleton remodeling and regulation of metabolism. The top two pathways in T3 CMMEF cells are cytoskeleton remodeling and cell adhe sion. Expression profiling of miRNAs The expression profiles of 365 human miRNAs in T3 HDF and T3 CMHDF cells were quantitated using TaqMan miRNA Assays as described previously, and the expression level of each miRNA was indicated as folds over U6 snRNA. The average values of triplicate analyses and fold changes for 365 miRNAs from these two different cell populations are given in Additional file 7, Table S3. The Pearson correlation coefficient of r 0. 9198 between T3 HDF and T3 CMHDF cells indicates their similar miRNA expression profiles.
The expression levels and fold changes of 35 most abundantly expressed miRNAs of T3 HDF and T3 CMHDF, as well as those of 31 miRNAs of T3 MEF and T3 CMMEF, cells are summarized in Table 2. These results indicate that nine hES cell spe cific miRNAs were abundantly expressed in T3 HDF and T3 CMHDF cells, and that miR 367 and miR 373 had little more than 2 fold variations between these two cell populations. In addition, eleven other miRNAs appeared to express more than 2 folds in T3 CMHDF compared with T3 HDF cells. It may also be noted that the miRNA data of T3 MEF and T3 CMMEF cells were previously determined using the set of 250 miRNAs in which miR 302a, 302b, 302c and 373 were not included, and that very similar expression profiles of miRNAs between T3 MEF and T3 CMMEF cells were also found pre viously.
No miRNA with more than 2 fold variation was found between the 31 abundantly expressed miR NAs of T3 MEF and T3 CMMEF cells. Protein patterns of 2D gel analysis The total soluble proteins extracted from T3 HDF and T3 CMHDF, Carfilzomib as well as T3 MEF and T3 CMMEF, cells were separated on 2D gels, and the silver staining pat terns of protein spots from these four hES cell popula tions appeared to be very similar. The similarities of protein spot patterns among these four 2D gels were analyzed using ImageMaster, and their results are indicated in Table 3. A total of approximately 1627 spots were separately detected, and approximately 1161 spots were matched among these four cell populations. It may be noted that the ranking orders of similarities among these four com parisons of protein spots were found to be the same to those of correlation coefficients of mRNAs and that the correlation coefficient between % protein match spots and correlation coefficient of mRNAs was found to be 0. 8122.
From our understanding, WT strain sellckchem could utilize the synergic effect of toxins and high level of cytokines to accelerate the penetration of deep tissue and BBB. These might be the reason why the strain could cause severe human diseases in Sichuan, 2005. Conclusions Microarray technology has been used to analyse the globle porcine transcriptional response to infection with various pathogenic microorganisms recently. Study on the transcriptional response to the Gram positive bacterium SS2 by using the Affymetrix GeneChip Porcine Genome Array has not been reported until now. Although great efforts have been made to understand the molecular basis of this infection, the response to SS2 infection is still largely unknown. Transcriptome analysis based on S.
suis infected spleens could improved the interference received by the cells analysis, and also supply the solid supplementary for analysis on alveolar macro phages. Highly pathogenic S. suis could persistently induce cytokines mainly by TLR2 pathway, and even tually the high level of cytokines and toxins secreted by phagocytosis resistant bacteria could destroy deep tis sues, and cause meningitis, septicaemia, pneumonia, endocarditis, and arthritis. Methods Bacterial strains SS2 strain 05ZY which was isolated from the brain of a diseased piglet collected in Sichuan outbreak in China 2005 showed high virulence to pigs, and was applied to infect pigs. An isogenic HP0197 mutant derived strain 05ZY showed no obvious virulence to pigs was applied as a control.
Animals infection and tissue collection All the experimental protocols were approved by the Laboratory Animal Monitoring Committee of Hubei Province and performed accordingly. A total of 12 pigs of high health status were assigned to three groups, within four in each. The pigs were determined to be SS2 free by antibody based ELISA and nasal swabs based bacteriologic test. One hour before inoculation, all pigs were given 2 ml of 1% acetic acid intranasally to enhance the sensitivity of the S. suis challenge. Two groups were inoculated intrana sally with 1 ml of 2��106CFU of WT strain or HP0197 respectively, and the rest group inoculated with PBS was served as control. All pigs inoculated with WT showed typical symptoms at day 3 while pigs inoculated with HP0197 or PBS showed no significant clinical signs. Blood samples from each group were detected for bac terial burden.
Bacteria Drug_discovery could be found in the blood of pigs in the WT group at day 3 post inoculation while no bacterium was found from the blood of pigs inocu lated with isogenic mutant strain or PBS at the same time point. All pigs were sacrificed at day 3, and their tissue samples were cultured to prove in vivo bacterial burden. Bacteria were found in the spleens of the WT group, and no bacterium was found in the other two groups. Spleen samples were aseptically collected and immediately frozen in liquid nitrogen for future RNA isolation.
In summary, metastasizing, but not non metastasizing, http://www.selleckchem.com/products/Erlotinib-Hydrochloride.html tumor derived factors induced MDSCs to produce more IL 6, and full activation of recruited MDSCs occurred in the primary tumor site and metastatic organs in the vicinity of metastasizing cancer cells. Activated MDSCs confer invasive potential on breast cancer cells and stimulate distant metastasis through IL 6 trans signaling We ne t evaluated whether activated MDSCs in the metastasizing tumor microenvironment affect breast cancer cell behavior. We cultured 4T1 and EMT6 cells in CM from splenic MDSCs cultivated in the presence of 4T1 CM or EMT6 CM. 4T1 cells cultured with splenic MDSC CM showed mild phosphorylation of Stat3. Moreover, 4T1 cells cultured with 4T1 MDSC CM, but not EMT6 MDSC CM, showed greatly increased Stat3 phosphorylation within 10 minutes.
Stat3 phosphorylation levels were increased for 48 hours in 4T1 cells cultured in the presence of 4T1 MDSC CM. Unlike 4T1 MDSC CM, however, 4T1 CM did not induce the persis tent activation of STAT3. Similar results were obtained for 4T1 cells co cultured with splenic MDSCs, but not for 4T1 cells cultured in the presence of recombinant IL 6. These data suggest that IL 6 was important in inducing Stat3 phosphorylation in 4T1 cells, but that factors other than IL 6 from tumor infiltrating MDSCs were needed for persistent Stat3 phosphorylation. The recent characterization of IL 6 trans signaling suggests that tumor microenvironments may pro vide soluble IL 6Ra as well as IL 6 to ma imally induce cancer cell aggressiveness through highly augmented IL 6 signaling, which is implicated in tumor cell survival, cancer stem cell characteristics and EMT phenotypes important for successful distant metastasis of cancer cells.
To investigate which cells in the tumor microenvironment provide soluble IL 6Ra, we measured levels of soluble IL 6Ra secreted from e vivo cultured splenic MDSCs from na ve, EMT6 cell bearing, and 4T1 cell bearing mice and 4T1 cancer cells. Anacetrapib MDSCs from tumor bearing mice generated more soluble IL 6Ra compared to 4T1 cells. Compared to those from na ve and EMT6 cell bearing mice, splenic MDSCs from 4T1 cell bearing mice produced more soluble IL 6Ra in e vivo culture. In contrast, splenic MDSCs from na ve, EMT6 cell bearing and 4T1 cell bearing mice e pressed similar levels of surface IL 6Ra chain. Production of soluble IL 6Ra involves cell surface associated proteases. Adam family proteases, especially Adam10 and Adam17, have been implicated in IL 6 trans signaling. Non stimulated splenic MDSCs from 4T1 cell bearing mice e pressed increased levels of both Adam10 and Adam17 compared to MDSCs from EMT6 cell bearing mice and na ve mice.
At the end of the treatment, it was close to that of the CHF group, but higher than that of the NC group. No difference was observed selleck chem in the body weight of mice among the NC, CR and HF groups before the dietary treatment. The body weight of the NC mice increased during the 26 week e periment, while that of the CR mice decreased slightly and remained relatively stable later. The body weight of the HF mice sig nificantly increased from 34. 9 0. 3 g to 55. 0 1. 0 g during the four month dietary treatment and they had 34% greater body weight than the NC mice, which were considered as moderate obesity. Both the SRT group and the NAM group dis played a body weight dropped during the drug administra tion, which were similar to the body weight of the CR group. However, the body weight of the CHF group remained relatively stable.
At the end of e periment, the perirenal fat pads were isolated and weighed as the visceral fat. The CHF mice had more visceral fat than the NC mice, while the vis ceral fat was less in the CR mice than in the NC mice. The SRT and NAM mice had similar visceral fat to the NC mice. The ovary weight Both the CHF mice and the NAM mice had heavier ovaries and higher ratio of ovary weight to body weight than those of the NC mice. However, the gross ovary weight and ovary ratio of the SRT group were similar to those of the CR group, but less than those of the NC group. Effect of SRT1720 and nicotinamide treatment on estrous cycles The estrous cycles of all mice were e amined before the treatment and only one of them represented an irregularly estrous cycle.
100% HF mice had e hib ited a shortened estrous cycle or continuous estrus phase since the 8th week of diet treatment. However, after 6 week SRT1720 administration, 50% SRT mice changed the continuous estrus phase to 3, 5 and 6 days, respectively. All the NAM and CHF mice maintained continuous estrus phase during the drug treatment. Dur ing the e periment, 87. 5% of the CR mice gradually e hibited an e tended estrous cycle due to a prolonged diestrus phase and only one CR mouse kept a regular at estrous cycle. Interestingly, two more CR mice and one SRT mice represented regularly again at the end of the study. Meanwhile, 75% NC mice maintained regular estrous cycles until the end.
Effect of SRT1720 and nicotinamide treatment on ovarian follicular reserve Comparison of the healthy follicles and atretic follicles among groups HE staining results showed that mouse ovaries were mainly consisted of healthy follicles, corpora lutea and atretic follicles. The number of healthy follicles Dacomitinib in the SRT1720 group was similar to that of the CR group, but more than that of the NC, CHF and NAM group. The number of atretic follicles in the SRT1720 group was similar to that of the NC group but less than that of the CHF group and the NAM group, while the number of atretic follicles in the CR group was less than that of the NC group.
Despite its implied involvement in a variety of physiological processes, the regulatory role of SIRT1 in oral cancer metastasis is poorly understood. In this study, we demonstrated for the first time that SIRT1 is a critical negative regulator of EMT and selleck chem cell migration in vitro, and also of tumor metastasis in vivo. Our studies showed that compared with e pression in HOK cells, SIRT1 was overe pressed in both OSCC cell lines, and a similar result was found in an enzyme activity e periment. We also found that activation of SIRT1 in oral squamous cell carcinoma resulted in decreased cell migration and invasion. Therefore, we propose a molecular mechanism whereby SIRT1 regulates cell migration by interacting with and deacetylating TGF B inducing transcription factor Smad4 to suppress MMP7 e pression.
We found that increased levels of SIRT1 in oral squamous cell carcinoma tissue contributing to decreased Smad4 acetylation and repressed MMP7 activity. In addition, our findings revealed that an absence of SIRT1 led to Smad4 hyper acetylation, MMP7 hypere pression, and degradation of E cadherin on the cell surface. These events resulted in release of B catenin from the E cadherin B catenin comple junctions leading to the nucleus, and pro moted metastasis of OSCC cells. In addition to the in vitro data showing that up regulation of SIRT1 led to low cellular invasiveness and migratory abilities, SCID mice with SIRT overe pressing OSCC cells showed significantly less lung metastasis com pared to control mice.
The EMT process represents the critical event in the transition from early stage to invasive carcinoma, and E cadherin downregu lation is well associated with poor prognosis, lower survival, and higher rates of metastasis in OSCC patients. Our results showed that SIRT1 overe pression reduced oral cancer cell migration and metas tasis, and these effects were largely independent of any general effects of SIRT1 on oral cancer growth and sur vival. Taken together, these data suggest that SIRT1 may prevent oral cancer metastasis by blocking the EMT process. Interestingly, our results differed from previous reports which indicated that SIRT1 serves as a positive regulator of epithelial mesenchymal transition, the metastatic growth of prostate cancer cells, and is associated with malignancy in chronic myelogenous leukemia.
Additionally SIRT1 involvement has also been suggested in epigenetic silencing of DNA hypermethylated tumor suppressor genes in breast cancer cells. Recently, SIRT1 has been shown to be an important target of miR 200 in regulating breast cancer cell migration. Additionally, SIRT1 is highly e pressed in various cancers such Dacomitinib as prostate cancer, and high levels of SIRT1 e pression are associated with a poor prog nosis in lung cancer, breast cancer, gastric carcinomas, and B cell lymphoma.
These results suggested that despite the important function of vAT Pase in all arthropods, developmental stage specific and species specific differences might exist that could explain the results obtained after gene knockdown in horn flies. Proteasome component sellckchem Proteasomes are large protein complexes involved in pro tein proteolysis that are functionally related to ubiquitina tion and thus essential for eukaryotic cells. Experiments in D. melanogaster showed that knockdown of proteasome subunits leads to increased levels of ubiqui tin conjugates, cell cycle defects, DNA overreplication, and apoptosis. In tick cells, 26S proteasome levels when compared to controls but did not affect tick survival, feeding and reproduction.
However, based on the essential proteasome function in eukaryotic cells, it was not surprising to observe a decrease in oviposition in horn flies injected with proteasome components dsRNAs target ing proteasome subunit beta and protea some maturation protein. As previously shown in D. melanogaster, proteasome subunits knockdown in horn flies may affect cell cycle and DNA replication thus resulting in reduced oviposition. Immune response Innate immune response is essential for insect survival. Only two unigens were assembled into this category and knockdown in female horn flies. Assembled unigenes encoded for putative T cell immunomodulatory protein and RNAse L inhibitor. Silencing of these genes resulted in higher horn fly mortality and lower oviposition when compared to controls.
These RNAi results may be due to an effect of gene knockdown on increased susceptibil ity to persistent pathogen infections resulting from impaired immune response in horn flies. Knockdown of immune response genes may affect the mechanisms involved in the control of persistent infections such as those caused by Nora virus and Wolbachia spp. which could affect horn fly mortality and ovisposition. RNAi knockdown of immune response genes in other arthropods results in increased mortality and higher pathogen infection levels. 5 nucleotidase 5 NUC and other ectonucleotidases control the levels of extracellular nucleotides and nucleosides that act as sig naling molecules involved in a wide spectrum of biologi cal effects. 5 NUC is commonly expressed in the salivary glands of blood sucking ectoparasites. Herein, as previously shown in ticks, 5 NUC knockdown resulted in higher fly mortality and lower oviposition when compared to controls. As in other organisms, these results suggested an essential Brefeldin_A function for 5 NUC in horn fly females.
AhR enriched regions without the DRE core were also verified, further demonstrating that the AhR can interact with DNA independent of a DRE core, but does not eliminate the possibility of AhR interaction through DNA looping or protein tethering. Interestingly, the fold enrichment values for regions with out the Enzastaurin DRE core were consistently lower than those with a DRE core, suggesting AhR interactions are stronger in regions containing a DRE. DRE Analysis of AhR Enriched Regions TCDD elicited changes in gene expression are mediated through AhR signaling via binding to the substitution intolerant DRE core sequence. Overlay ing TCDD induced AhR enrichment with DRE core loca tions throughout the mouse genome identified 57. 8% and 48. 5% of the enriched regions did not contain a DRE core regions at 2 and 24 hrs, respectively.
Other promoter specific ChIP chip stu dies have also reported DRE cores in 50% of the AhR enriched regions. The remaining enriched regions possessed at least one and as many as 16 DRE cores. AhR enriched regions with or without a DRE core exhibited similar widths and levels of enrichment. Matrix similarity scores have been calculated for each 19 bp DRE sequence within the mouse genome using a position weight matrix constructed from bona fide functional DREs. Of the 6,595 significant AhR enriched regions containing a DRE core, 90. 7% were within 500 bp of a DRE core with half of these positions located within 135 bp of a DRE core. However, only 8. 3% and 17. 8% of the AhR enriched regions at 2 and 24 hrs, respectively, possessed a putative functional DRE sequence sug gesting the AhR may bind other degenerate sequence elements.
AhR binding to an alternate response element has also been reported. Of the 8,353 and 472 enriched regions at 2 and 24 hrs, respectively, that did not contain a DRE core, 482 and 237, respectively, contained the alternate DRE sequence. The higher incidence of AhR enriched regions at 24 hrs containing the alternate response element may represent tertiary AhR binding sites resulting from conformational changes and crowd ing of the promoter with the general transcription machinery. Transcription Factor Binding Site Over Representation Analysis Significantly AhR enriched regions were computationally analyzed for over represented response elements for known TF binding site families using RegionMiner.
DREs as well other sites for early growth response, E2F, nuclear respiratory factor 1, nuclear receptor subfamily 2 factors and peroxisome proliferator activated receptor were over represented within Entinostat AhR enriched regions. Many of these TF sites were enriched proximally to a DRE core suggesting possible interactions. Stu dies have previously reported interactions between AhR and many of these TFs. For example, AhR com plexes with EGR 1 following treatment of human HUVEC cells with high glucose concentrations.
The metabolomics approach used here measured only metabolite pool sizes at the time that tissues were harvested, rather than the effect of fasting or insulin neutralization on the rates of metabolism through together glycolysis and the TCA cycle. The latter would be much more informative with respect to the dynamic impact of treatment, but requires the use of isotopic labeling which was not performed in this study. Nonetheless, we were able to demonstrate significant effects on some metabolites that inform the parallel changes in gene ex pression, particularly in relation to amino acid metabol ism. Combined clustering of metabolomic and gene expression together identified a set of genes correlated with many amino acid levels, including PIK3R1, ME and MCD.
Conclusions In summary, we determined that adipose tissue metabol ism in the chicken is regulated by energy status and, to a lesser extent by insulin. Although adipose tissue is not a primary site of lipogenesis in chicken, the rate limiting genes for fatty acid synthesis were suppressed by fasting. Likewise, fasting appeared to increase aspects of insulin sensitivity based on expression profiles, despite the view that chicken adipose tissue is relatively insensitive to insu lin. Consistent with this paradigm, insulin neutralization significantly altered the expression of only a few genes related to glucose and lipid metabolism. Nonetheless, a considerable number of genes were altered by insulin neutralization, many of which thus far have unclear roles in adipose biology.
Expression profiles suggest that even short term fasting alters fat storage in broilers by enhan cing the oxidation of fatty acids. The initiating events that trigger upregulation of the corresponding genes are un clear, but there is considerable evidence for activation of PPARa, LXRa, and potentially other transcription factors that are activated by fatty acid ligands. Further studies are warranted to identify these triggers because of their poten tial impact on fat storage. Our data also suggest that broiler chicks may be an informative model organism in which to investigate dietary effects on adipose develop ment in light of what appears to be a relationship between energy intake and adipogenesis. The results of this study thus have dual benefit for both the poultry industry and for studies of obesity in humans.
Methods Animals Male broiler Cilengitide chicks from which samples were collected for this study were hatched and raised under standard conditions, as originally described by Dupont and in accordance with the guidelines for Care and Use of Agricul tural Animals in Agricultural Research and Teaching. Briefly, at 16 17 days of age, chicks of similar body weights were either allowed to continue feeding, fasted for five hours, or fed but injected at 0, 2 and 4 hours with porcine anti insulin serum. Both the fed and fasted groups received injections of normal porcine serum as a vehicle control.
Future work will be required to estab lish the role of immune physiology and cellular defence mechanisms in the regenerating fish skin and also the involvement of stem cells in this process. At the same time as the immune response, there is a clear requirement to rapidly re construct http://www.selleckchem.com/products/Trichostatin-A.html this external bar rier with various genes involved in metabolic processes such as amino acid biosynthesis and also cell division and proliferation. Interestingly, in a link with the IPA results, several of these genes have been described in cancer stu dies.
Cyclin dependant kinase inhibitor is involved in hae matopoietic cell cycle regulation and has been shown to be over expressed in breast and prostate cancer, S phase kinase associated protein interacts with c myc dur ing the G1 S phase transition of the cell and is a co factor of c myc which is a known transcriptional regulator of oncoproteins and involved in cell growth, apoptosis and oncogenesis, whilst the mitotic check point serine threonine protein kinase has been shown to be preferen tially expressed in cells with a high mitotic index. Adaptation to new conditions involves an element of cytoskeletal re modelling, as evidenced by the up reg ulation of cytokeratin which has been associated with epi dermis development, fibrinolysis and also regulation of angiogenesis. It is tempting to speculate that the up regu lation of cytokeratin in response to scale removal may represent a keratinization like phenotype provoked by the osmotic shock.
There was also up regulation of genes involved in apoptosis such as Galectin 3 and the multi functional S phase kinase associated protein and the somewhat confusingly named cation trans port regulator like protein. Hence competing inter ests between infection inflammation control and cellular proliferation tissue repair in fish with scales removed appear to be ongoing. The effect of food deprivation with no scale removal Skin tissue metabolism is clearly being redirected as the animals cope with adaptation to food deprivation. One he up regulation of angiopoietin related protein 4, MYND and KIAA0711, all of which have been shown to play roles in the inhibition of proliferation. Another regulator of a proto oncogene is present in the form of ubiquitin carboxyl terminal hydrolase and levels of MYC decline is response to intracellular stress signals. Molecular signals of cell stress are also present with up regulation of antioxidants. During periods of food deprivation fish seem to main tain energy homeostasis, at least during the initial stages of fasting, by mobilizing energy reserves such as lipids and hepatic glycogen and reduction Cilengitide in the rate of glu cose utilization and enhancement of lipid metabolism.

domain: literature


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The second season of DOTA’s animated show Dragon’s Blood will be available to stream on January 6, 2022. As spotted by DOTA 2 community figure Wykrhm Reddy, the Netflix page for DOTA: Dragon’s Blood Book 2 now has a release date and a swanky new trailer to boot.
The trailer is a moody affair, as you might expect. We start with several shots of glowing purple lotuses fading into the wind while one man tells a woman that she’s no longer worshipped and that all that sustains her is a spark of divinity. We then get some shots of the demon marauder Terrorblade looking suitably broody as he hunts for more Eldwurm souls. We also see scenes of conflict and war, which sets us up for a potentially war-heavy season.
If you’ve been out of the loop, the show is being created by Ashley Miller, who has worked on superhero movies like Thor and X-Men: First Class. We also have Kaiju Boulevard and Studio Mir on production duties, who you might recall is working on the animated Witcher prequel The Witcher: Nightmare of the Wolf.
You can catch the trailer below:
— Wykrhm Reddy (@wykrhm) December 9, 2021
Plenty is going on in DOTA 2 as well. The MOBA game’s next battle pass is “due out in the next few weeks”, so you’ll have some content to keep you busy while you wait for the show to launch.
If you’re looking to get into one of Valve’s most popular games, check out our best Dota 2 heroes for beginners guide. It’s a real treat.

domain: entertainment


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The end result of all this is that many libertarians see no compelling reason to support the Republican right they identify with John Ashcroft and Sen. Rick Santorum. By default this means that they often end up working with the left. They've joined with the ACLU and other traditionally liberal civil libertarian organizations to oppose Patriot Act-style legislation (although some prominent conservatives joined them in opposition). Antiwar libertarian bloggers and Internet columnists often link to left-of-center websites like Indymedia, Common Dreams, Alternet.org and CounterPunch in making their arguments.I think a lot of the hype over the Patriot Act is unwarranted (I'm not alone in this), and I supported, and still do support, the administrations strategy, if not tactics, in Iraq. But I do agree that the GOP has seriously lost touch with its small government raison d' etre. The GOP is all in favor of a large, intrusive govvernment, as long as it intrudes into the right place, bedrooms instead of boardrooms. This is philosphically inconsistent and leaves would be supporters (like me) scratching their heads in wonder. I don't think, as Antle points out, that Howard Dean is the answer. Sadly, I don't see a legitimate candidate who could carry the small government banner in the next few election cycles from either party. Any ideas?
Wednesday, August 27, 2003
The GOP/Libertarian split: I still see myself as a conservative, but recent events, particluarly the recent Supreme Court rulings, have raised a more Libertarian streak in me. It seems this division between the two camps who, supposedly, are the champions of smaller government is getting wider. James Antle, in Tech Central Station, examines the split.
Posted by Flyer at 12:13:00 AM

domain: politics


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Yup. Also had the outbreak featuring the Marseilles, Washburn & Crossville EF3s and the Perryville, MO-Christopher, IL EF4. This on the heels of one of the more notable icing events in southern Wisconsin in recent memory (for me at least). We actually had enough accretion to noticeably weigh down the trees, and leave a clear glaze on everything even after the sun came out the next day.
2016 also had a relatively early season outbreak in the region; March 15th seemed about the earliest possible non-ridiculous time of year (remembering events such as 3/13/90 and 3/12/06) for this area to me so I went out and chased, got a glimpse of the Trivoli-Hanna City EF2.
Of course, when the next year rolled around, late February just seemed way too **** early so I sat that one out. Apparently the lesson didn't stick because I also sat out the Winterset day in 2022 because I thought March 5th was too early, although in my defense that setup also looked rather marginal on most of the model runs in the days leading up to it. By the time it began to look genuinely good closer to go time, I had already talked myself out of chasing. Keota day last year was also quite early season for the region, but with it being a moderate/eventually high risk and the models consistently showing that (lack of) deep moisture return would not be an issue, confidence was much higher.
Now of course in 2024 we get something truly stupid, with tornadoes in Wisconsin on February 8th, with dewpoints not even reaching 50, and one of those being one of the longest-tracked and most impactful in the south-central part of the state in nearly ten years (going back to the cluster of late-night strong tornadoes on June 16-17, 2014, when an EF2 missed my apartment building by about two blocks while I was staying in a hotel, having driven to eastern Nebraska to whiff on what turned out to be the Pilger event).
Ironically, the least likely six-week period out of the year to get tornadoes in the Midwest in recent years seems to have become what should be the peak; May through mid-June.

domain: geography


In a written reply, Union Housing and Urban Affairs Minister Hardeep Singh Puri said a subsidy of Rs 5,320 crore has been disbursed so far under the Credit Linked Subsidy Scheme (CLSS) in the current financial year.
"During FY 2021-22, an amount of Rs 8,000.00 crore (including Rs 1,000.00 crore for CLSS component) was allocated for PMAY-U in Budget Estimates (BE) which has now been enhanced to Rs 27,000.00 crore (including Rs 12,000.00 crore for CLSS component) at Revised Estimates (RE) stage in consultation with Ministry of Finance," Puri said.
The Pradhan Mantri Awas Yojana-Urban (PMAY-U) launched in June 2015 aims at giving central assistance to states, UTs and Central Nodal Agencies (CNAs) for providing houses to all eligible families and beneficiaries in urban areas of the country within scheme period up to March 31, 2022.
Replying to another question about the Smart Cities Mission, he said the government has spent Rs 3,013.73 crore on slum redevelopment projects so far under the SCM.
Under the Smart Cities Mission, projects, including those related to slum redevelopment, are proposed and implemented by cities in accordance with their Smart City Plans (SCPs).
(With PTI inputs)


Article provided by: Lube Masters Express
Vehicles have been a primal inclusion in the American lifestyle. The conventional masculinity of the American male includes riding a macho horse or popping the bonnet for a DIY project. It is a culture for us to change work through the specific motor functions before introducing a mechanic to the picture.
Vehicle mechanics have come a long way since the simplicity of the early vehicles. Life is also much busier and does not involve spending half the day at the town center or the farm. We need skilled mechanics to take the load off our schedules by handling minor and major car issue. One crucial car maintenance to-do list is a car lube near Plano.
What is car lube?
Car lube is synonymous to car oil. It is the same as getting your car an oil service. Oil services are standard and serve a critical part in maintaining the car’s health.
What is the purpose of car lube?
- Lubricate the engine
- Transfer heat from the engine’s inside to the exterior
- Prevent the buildup of dirt due to the constant movement of fluid to different parts of the engine
Cons of changing your oil
Plenty of people find it easy to change their car oil. A few have been on the unlucky side of the scale when they experienced unique complications. It is better to invest in a used car if it generates additional problems. A new vehicle could be equally risky when it has a different and complicated engine setup.
It is difficult
Changing the oil requires you to lift the car off the ground using a floor jack. People who do not have frequent mechanical issues will most likely not have the necessary tools. You do not have to risk doing the wrong job due to poor visibility. A professional at Lube Masters will take half the duration to do an excellent lube service.
One single mistake could cost you plenty of dollars. Home service is not as novice as one from a highly-skilled professional. You should spend a small fee getting quality work done than risking extra hours and money towards the repair.
Doing your lube service will require that you pay retail to acquire all the right tools. Lube Masters has all the devices and will purchase additional ones at a wholesale price. Labor costs a small amount and will save you a great deal in the end.
Car dealerships and manufacturers will not process your warranty if you damage a part of the car during repair. They require receipts from licensed car mechanics to maintain the validity of the agreement. It is not worth it to risk losing your purchase due to simple oil service.
You can spare a few hours off from work to get a car lube near Plano. You may end up wasting an entire weekend trying to work out all other facets of the engine if you use YouTube as guidance. Bring your car to our shop and enjoy ticking off a few tasks off your to-do list while simultaneously getting quality oil services.
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Entertaining, exciting, and a humdinger of a cliffhanger at the conclusionAre you okay Have you looked in to the Glass yet Jenna s voice came from the cupboard Um yes I m looking now What can you see Nothing.
nothing it s just dark oh, wait I can see something now it it s weird an old man staring at me He looks kind of surprised An old man asked Jenna Oh, that s odd What Jenna could bear it no longer She hurtled down the steps and arrived in the Robing Room just in time to see Septimus spring back from the Glass, slip on the shiny marble floor and fall As he scrabbled to get up and away, Jenna screamed Reaching out of the glass we re too old, wizened hands With long bony fingers and curved yellow nails, they snatched at Septimus is tunic, grabbed hold of it, then wrapped themselves around his Apprentice belt, dragging him toward the Glass Frantically Septimus tried to pull away, kicking out at the clutching talons Jen Help, Je he yelled, and then there was silence Septimus s head had disappeared into the Glass as though sinking into a pool of ink.
Physik by Angie Sage is the third book in the Septimus Heap series and was just as exciting as the first two I m listening to this series on audiobook, narrated by Gerard Doyle,whose flawless, 5 performance adds an extra bit of excitement to the story I really enjoy the characters in this series as they are unique and enchanting Angie Sage effortlessly creates both likeable characters, horrible, evil characters, and some who are a bit of both The adventures are treacherous and keep me intrigued and captivated from beginning to end, making it difficult to stop listening I m always looking for excuses to return to the story as often as possible The ending of this book left me on tenterhooks, anxiously awaiting to listen to Queste, the next adventure in the Septimus Heap series I m a big fan of this series Ghosts, witches, dragons, spells, secret cupboards and tunnels, boggarts, sailing ships, queens, wizards, herbs and magic ringseverything you could possibly imagine in a magical castle realm Mix that with Shakespearean style mischief comedy of errors very human errors and mistaken identity And, on top of all that, the characters are lovably ordinary the children make friends in a natural, uncalculated way, and the adults are soimperfect Lots of fun I tried persevere I really did I read the first two from beginning to end I couldn t do it with this one The tediousness and annoyingly long paragraphs explaining every thought and action became too much for me The book could really have been done in 100 pagesif that I ended up skimming quickly through it, after reading the first ten chapters, and then I read the bits at the end about what happened to characters I got the gist of the book just by doing that and saved myself manydays of dragging this book out I really couldn t even bare the idea of extending it with the library, I wanted this book out of my house So it s now safe to say, I won t be reading the last two books My curiosity just isn t bothered about finding out what happens to everyone Thank god I never bought them as I had originally intended to Reviewed by Me for TeensReadToo.
comI have to state that it s taken me a very long time to write my review of Physik, mostly because it took me such a very long time to finish the book Although I absolutely loved MAGYK, and was nearly as impressed with FLYTE, it was much harder for me to get into the story of Physik I wasn t immediately struck by the newly introduced characters, and even some of my old favorites were, at first, acting quite different than they had originally That being said, though, I m glad I finally finished this third installment in the Septimus Heap saga, and can recommend it to others without feeling guilty The story opens with Silas Heap, father of the Heap clan, unknowingly unleashing the ghost of Queen Etheldredda, a Castle Queen who ruled long ago Along with her spirit is also released that of her pet Aie Aie, a rat dog snake hybrid that is hideous to look upon Although Silas and his companion, Gringe, aren t first aware of what has happened, they ll soon learn that the room they unlocked would have been better left alone Nearly at the same time, Snorri Snorrelssen, a young North Trader, arrives at Sally Mullen s Tea and Ale House and can immediately sense that she s not welcome there, even if she can t understand the language that s being spoken After weeks at sea, however, Snorri is not about to turn her back on her mission, that of following in the footsteps of her father Back at the Palace, Septimus Heap is putting off his studies with ExtraOrdinary Wizard Marcia Overstrand, instead indulging in his new obsession of learning all there is to know about Alchemy He wishes to learn under the famous Alchemyst Marcellus Pye, who just so happens to be the son of the dreaded Queen Etheldredda All of the usual characters are back in this installment Jenna, Nicko, Aunt Zelda, Spit Fyre, and Alther Mella, along with new ones like the above mentioned Snorri and Marcellus Pye Some of them act as they ve always acted some of them act in surprising ways All of it leads up to a showdown of wits and talents and, of course, the next book in the series As I said, I m glad I finally finished reading Physik, as I definitely plan to read QUESTE, the fourth book Although some readers may have trouble in the beginning, as I did, once you get into the story of Septimus and family, you ll be quite enthralled until the very end.
Saking sukanya, 600 halaman pada buku ini aku baca kurang dari 24 jam Ini salah satu hal yang luar biasa banget buat aku p Kisah Septimus bersama keluarganya ini makin seru Lebih seru lagi dari cerita di dua buku sebelumnya Recommended bagi siapa saja yang menyukai kisah fantasi dengan keajaiban keajaiban sihir yang unik dan juga memikat D
You know, I hate book reviews I always feel so inadequate when I like a book other people have panned, and although I don t know of anyone who has read this series and didn t like it at least somewhat, I still feel that my support of these books is on shaky ground insert slightly whiney voice here But I really like these characters And I really like the plots And I really like the crazy narratorial style We zoom around from person to person and it works for me, but then I m always interested in what the other people in a story are thinking, and most of the time those feelings are only hinted at with shrugs, and sighs This is also why I like the Bartimaeus Trilogy, and Artemis Fowl But then maybe I like all these books because they are well written.
and fun It s kinda like Harry Potter mixed with the Lord of the Rings meets like the Time Warp Trio or something I ve really gotten into them, but they re long The fourth one, Queste is almost 600 pages and the rest are like 500 some They usually take me a month to read unless it s the weekend and I have nothing else to do, then it takes like three days My mom, brother and I all are reading them right now.


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Physician-sponsored health plan gets startup federal loan
■ The insurance company was funded under a program created by the Affordable Care Act and pledges to live on even if the act doesn’t.
A physician-sponsored insurer is one of the 14 consumer-owned and operated health insurance plans, or CO-OPs, starting up around the country, thanks to federal loans made available through the Affordable Care Act as a means to create more coverage options for the millions of Americans required to begin buying insurance in 2014.
HealthyCT, sponsored by the Connecticut State Medical Society and CSMS-IPA, a statewide independent practice association, received a $75.8 million loan from the U.S. Dept. of Health and Human Services, joining 13 other CO-OPs with startup funding from the government. The solvency loans are meant to help CO-OPs qualify for state licensing requirements, which often include the financial backing to cover catastrophic losses. In all, $1.5 billion has been awarded to CO-OPs in 14 states as of June.
The CO-OP program is meant to create an alternative to the health plans available before health system reform, and is seen by some as a compromise for supporters of a public option health plan. Because they are meant to help new insurers get off the ground, loans are not available to for-profit plans or any entity that operated a health insurance plan before July 2009 (link).
Some health centers and hospitals are co-sponsoring CO-OPs, but HealthyCT is the first physician-based CO-OP to be awarded a federal loan.
“CSMS sees HealthyCT as a model that may be used by other medical societies interested in exploring the CO-OP arrangement,” said Matthew Katz, executive vice president and CEO of the Connecticut State Medical Society.
CO-OPs are authorized under the Affordable Care Act, which is being reviewed by the U.S. Supreme Court. The loan paperwork already has been signed, so even if the court declares ACA unconstitutional, HealthyCT wouldn’t lose its funding unless Congress were to take action to retroactively rescind the loans. That is an unlikely scenario, said David S. Katz, MD, a general surgeon from Milford, Conn., who is board chair for HealthyCT.
Even without an individual mandate to buy health insurance under the ACA, Connecticut’s health insurance market could use a new entry, so the company’s business plan isn’t dependent on the reform bill, Dr. Katz said.
He said CSMS polled its members a few years ago and discovered they were searching for affordable health coverage for themselves and their staffs. But even with 5,600 people who said they would buy in to a plan offered by the medical society, CSMS couldn’t get a health insurer to underwrite it.
The next step for HealthyCT is licensure through the state insurance department, Dr. Katz said. The plan then can set up headquarters and hire executives and support staff and begin offering coverage. He said the HealthyCT plan probably will feature an open, PPO-style network, but will work to support the patient-centered medical home model, focused on quality and fair compensation for physicians.
“We saw it as an opportunity to change the paradigm of how health insurance is delivered,” he said. “We’re not just getting into this to be another insurance company just like all the others.”

domain: economics


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Graphic Design BFA students enrolled in Communication Design 2 in Spring 2023 build visual communication skills by researching and exploring influential ideas in graphic design from a historical perspective. With a deep focus on creating a strong relationship between content and form, each student’s process involves experimentation with a specific design convention within a contemporary, personal context. These pieces convey what student’s have learned in the past year about themselves, academics, culture, politics, relationships, etc. while also exhibiting what they have learned about effective visual communication — composition, conceptual thinking, image-making, creating unity and variation within systems, and unconventional formats.
For the curators, archivists, and librarians working in Special Collections Divisions across the state and the country, maintaining a historical record through the collection of manuscripts, multimedia, and printed forms is not only important to their work, but also necessary to their institutions. Despite all of this, we are often unaware of the need to maintain our own records for future use.
A History of Special Collections is an exhibition that considers the archival history of the archives themselves, and demonstrates the importance of developing and maintaining such institutional knowledge.
From the early antecedents in the Utah Room to the most contemporary iteration, this exhibition traces the trajectory and evolution of the Special Collections Division at the Marriott Library over the last seven decades. Join us in exploring the unique holdings from each of the departments – now on display in the Special Collections Exhibition Gallery on Level 4. What’s revealed is a story of dedication, scholarship, and commitment to research and access.
The underground addition to the University of Utah’s J. Willard Marriott Library, commissioned in 1992 and completed in 1996, was the fourth in a series of underground library additions designed by Michigan-based architecture firm Gunnar Birkerts and Associates. Largely ignored by critics in their time, these projects have gained new relevance today because of their environmental performance characteristics as well as their delightful, inspiring daylighting strategies.
Curated by Michael Abrahamson, this exhibition of archival sketches, drawings, and photographs from the Bentley Historical Library, University of Michigan and the Balthazar Korab Collection, Library of Congress reveals the evolution of this distinctive project type in the hands of Birkerts and his employees over two decades, at the ends of which the Marriott can be seen as a culmination.
For the past 75 years the University of Utah College of Nursing (CON) has unified and inspired scientists, educators, clinicians, staff, and students to design, lead, and achieve improvements for the well-being of all.
In 1948, the CON became the first nursing college in the state of Utah. Since then, its faculty and staff have played a vital role in shaping the fields of nursing and gerontology. This exhibit showcases images from past and present, highlighting how the CON has evolved throughout the decades–honoring our past, and inspiring our future.
This exhibit and the online exhibit were made possible by the dedicated work from the Eccles Health Science Library. Thank you, Carmin Smoot, Elaine Thornton, Bryan Hull, Mike Thelin, and Dr. Beth Vaughan Cole (CON Emeritus Professor).
This exhibit highlights images from the Utah Association of Chinese History Photograph Collection (P0897), which features portraits of professionals and community leaders working in fields including business, science, government, religion, education, and the arts at the end of the 20th century.

domain: design


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SAN FRANCISCO, July 18. -- The will of Miss Bertha Marion Dolbeer, who jumped to death from a high window at the Waldorf-Astoria Hotel in New York several days ago, has been filed for probate. View Full Article in Timesmachine »
Full text is unavailable for this digitized archive article. Subscribers may view the full text of this article in its original form through TimesMachine.

domain: news


Thailand's junta has formally begun cracking down on the internet after television channels were ordered off the air except to carry the army's announcements.
The National Peace and Order Maintaining Council (NPOMC), which is presently running the southeast Asian nation, has told the country's internet service providers [ISPs] to block all content in cyberspace which is seen as violating coup orders.
Officials from the council, which is led by General Prayuth Chan-ocha, held talks with representatives of various ISPs earlier in the day.
Live television broadcasts and access to IPTV have also been ordered to be blocked, a source told the Nation.
Morragot Kulatumyotin, managing director of leading internet provider INET, said general online communications are not affected. However, anything that is against the junta is banned.
"INET would like to tell the people to use the internet normally, but they should avoid forwarding messages that they are not sure about their fact," said Morragot.
Meanwhile, Prayuth told high-ranking military authorities during a meeting that the coup was necessary to resolve the months-long political crisis.
He said he had to make "sacrifices" in order to take over power to safeguard national interests.
Security has been beefed up at border crossings and scores of political figures have been ordered to remain inside the country.
The Pheu Thai Party, which was in power, is reportedly awaiting orders from former prime minister Thaksin Shinawatra to deal with the situation.
For the past six months, Thailand has been grappling with severe anti-government protests that forced then prime minister Yingluck Shinawatra to dissolve parliament and call for fresh elections on 2 February.
The anti-government protests were originally set off by a controversial amnesty bill which might have allowed Yingluck's brother and former leader Thaksin to return from his self-imposed exile.
Thaksin was overthrown in a military coup in 2006 and Yingluck was accused of running the government as his proxy.


In September 2009, a tsunami hit the island of American Samoa, destroying the Satala power plant, one of the main power generation facilities on the island, and leaving the isolated, Pacific community with an 18 MW power shortfall. Emergency relief efforts were supported by the United States Federal Emergency Management Agency (FEMA), and a temporary system was deployed. About one year later, the American Samoa Power Authority (ASPA) issued a Request for Proposal (RFP) for a temporary power generation system to provide 18 MW of continuous, reliable electric power to operate for approximately two to three years until the Satala power plant could be rebuilt.
The RFP requested a flexible, modular system that could be redeployed after the Satala plant was completed. It specified using ISO certified containers for component packaging to allow for maximum flexibility, and ease with handling, installation and relocation. In addition, it required a flexible configuration with the ability to operate as two sites with up to eight generator sets, as an independent system, as one large combined system and with or without being in parallel with the existing utility grid.
The power plant needed to meet the demands of a tropical location, and include a comprehensive Supervisory Control and Data Acquisition (SCADA) system to provide local and remote monitoring and control capabilities. Finally, the entire power plant had to be fully functional within eight months, or risk significant financial penalties for missing the deadline.
Cat® Dealer Hawthorne Power Systems partnered with Enercon Engineering to provide a detailed bid that included design and engineering information, system configuration and optimization, and site implementation and planning. Hawthorne was the primary contractor, providing the generator sets, project management, logistics, and site installation labor and coordination. Enercon Engineering served as a subcontractor, providing the custom container fabrication, packaging, switchgear and controls, fuel tanks, SCADA system and testing at Enercon’s Phoenix, Arizona, facility.
The system design called for 11 Cat 3516C diesel generator sets rated at 1,650 kW each at 13.2 kV and 60 Hz. The 3516C generator sets are EPA Tier 2 compliant and run on ultra low sulfur diesel fuel to minimize emissions. Each features a 16 cylinder vee-type engine with an air-to-air aftercooler, a 6.69 inch (17 centimeter) bore, 7.48 inch (19 centimeter) stroke, 69.0 liter displacement and individual cylinder temperature thermocouples.
To meet the specifications of the RFP, each generator set is housed in a custom-built, fully stainless steel container. Built by Enercon Engineering, each 40-foot cube container meets ISO and CSC specifications, and is fabricated from specialized, selected grades of stainless steel to provide for superior corrosion resistance.
The design of the containerized generator sets is based on a traditional, rental-fleet power modular concept, and includes local switchgear and paralleling controls in each unit to provide the ability to operate individually or as a group, depending on the application.
The two lineups of main switchgear – one for each site – are also housed in custom-built, stainless steel, 40-foot, ISO-certified cube containers, and are configured so that each can easily be relocated to meet application needs.
Each generator set is connected to one of the two main lineups of switchgear through a disconnect switch in the switchgear and the individual local paralleling circuit breaker. These main lineups also each feature a utility tie breaker, several feeder breakers and a bus tie breaker. The main switchgear lineups also each feature a PLC system to gather and process system information through communications and input/output modules. This control system is fully compatible with the existing monitoring system and capable of remote controlling the generator sets.
The SCADA system, designed and implemented by Enercon Engineering, compiles information from all system components and creates a seamless interface for monitoring and control.
Once all equipment was fabricated and shipped to American Samoa, Hawthorne sent a team to work with ASPA on installation of the plant. Hawthorne was responsible for all aspects of the installation, including site erection, fuel system piping, control and low voltage interconnect wiring, and final commissioning of the system. ASPA performed all site preparatory work and all medium voltage cabling.
Once the plant was installed and startup completed, a 14-day continuous run acceptance test was completed prior to turning plant operations over to ASPA. Turnkey installation and commissioning were completed in less than two months.
From the original RFP phase to the final commissioning process completed in late June 2011, this project allowed ASPA to partner with the Hawthorne and Enercon Engineering teams to design, construct and implement a fully integrated system for a tropical marine environment on a remote island in the Pacific. The team approach by Hawthorne and Enercon Engineering was essential to provide the comprehensive system delivered on time according to the demanding schedule.
Innovations and ideas produced and implemented on this project can confidently be utilized by other Pacific island power authorities to help them provide reliable, efficient power generation solutions to their residents. The modular approach combined with highly reliable and efficient operating generator sets can provide temporary power solutions with rapid mobilization for small systems less than 2 MW, up to large systems greater than 100 MW and include flexible operating options.
Producing reliable power from 2250 to 3125 kVA at 50 Hz, our 3516C diesel generator sets are made to meet your mission critical, continuous, standby and prime applications. We've designed each to ISO 8528-5 transient response requirements and to accept 100% rated load in one step. The 3516C generator sets are U.S. EPA Certified for Stationary Emergency Use Only (Tier 2 Nonroad Equivalent Emission Standards).Learn More


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April 7, 2017 UPDATE: Brenhill Developments Ltd. says they are not under an active RCMP investigation. See documents below.
In December, I reported on a controversial land swap deal between the City of Vancouver and a property developer. Glen Chernen of the South Vancouver Parks Society has found more on the fishy deal, the controversial assessment drops by BC Assessment and now, thanks to his complaint, the RCMP has begun an investigation into the matter.
Watch as Chernen and I discuss the new revelations since my last report in January, including yet another multi-million dollar assessment drop from BC Assessment as well as a controversial loan from BC housing to finance luxury condos.
And, Chernen lets us in on the fact that there are more of these kinds of shady deals involving city land being swapped to developers.


Newton County welcomed a new County Extension Coordinator on Wednesday, March 4.
Agriculture and Natural Resources (ANR) Agent Ashley Best had a meet and greet at Turner Lake and discussed how extension works and how it will better assist people.
Best is the liaison between the specialists’ research at the University of Georgia and the public in Newton County. She provides information to use at home or on the farm. Best also makes recommendations in areas that include: soil fertility, water quality, herd health and management, crop management and pest management.
On Wednesday, Best expressed why she feels extension is important.
“I feel that extension is a service that all residents in Newton should feel comfortable utilizing. Our services can assist with any agriculture and natural resource question or problem you might have," she said. “I work closely with specialists at the University of Georgia to problem solve for the community in a timely manner”.
The extension service provides free, trustworthy information based on the latest scientific research that is easy for the public to understand. All their products have been tested in the lab at UGA to ensure consumers are receiving the best resources.
“Agricultural is still the biggest industry in our state by far and most people do not realize it. It provides food for everyone," said Fred Greer, a local farmer. “To keep agricultural in top proficiency and production, Ashley is the extender of the research at the University of Georgia who brings agricultural to the people. If we don’t have extension and the research to provide we may not get the groceries at the grocery store. We are recipients of all this research that makes the food available for us.”
The extension keeps people updated through programs and workshops, field days, mass media, phone call and in-person consultations and online publications.
“I am excited for the opportunity to serve Newton County and get to know the members of the community," Best said. "I look forward to working with the farmers and growers as well as providing information to teachers, homeowners, lawn care workers and families”.


text: Nursing shortage is a serious problem in Taiwan. The objective of this paper is to investigate the role of supervisor support (SS) in the work-to-family conflict (WFC) and burnout relationship that impacts the professional commitment (PC) amongst nurses. Self-reporting data was collected from 410 nurses. A confirmed factor analysis (CFA) was used to test the validity of dimensions. A hierarchical regression analysis (HRA) and the correlation matrix were used to test the hypotheses. The collected data shows that SS strongly moderates WFC-burnout relationship after HRA analysis. The moderating effects of SS suggest that through SS, WFC's impacts on burnout diminish, and thus SS enhances PC of nurses. It avoids high turnover in the nursing profession. The results conclude that the supervisors of nurses should take the initiative to identify which nurse under supervision is facing a WFC problem, and support her to avoid the nurse's burnout, and thus reduce nurse turnover rate.


Every time a new Honda motorcycle is launched, it grabs headlines. But in the case of the CBR 650F, you just know that it’s going to be something special. It’s great to see heavyweights like Honda bringing in bikes with mid-range power in India. Though it looks pretty racy, Sarath straightaway pointed out that the 650F is more of a tourer rather than a sports bike. But that’s not a bad thing. As brilliant and sporty as it may appear, it’s actually quite easy to ride.
The usual perception is that if it is a tourer, then it can’t put the fear of God in you – as it’ll simply be too mellow. Well, the CBR 650F had a couple of things to say about that, as it clocked the fourth fastest lap time at the track. This was very impressive, since it finished behind three bikes that have bigger engine displacement and more power. The 648cc, like any Honda, is highly refined and has a nice sporty exhaust note. As expected from the ‘Big H,’ the power delivery is spot on as it can rev easily from 4,000rpm and go all the way up to 11,000rpm without a whimper.
The riding stance is worth mentioning too, as you aren’t forced to aggressively bend your knees – and it lets you ride comfortably for long distances or commute daily without any hassles. When it comes to handling, the 650F remains stuck to the tarmac and held its line without making us ever second guess the bike. Sarath commented, “It’s a Honda, so this is hardly surprising.” It’s not a light bike though, and while taking turns one can feel the 215 kilograms. But what was disappointing was the use of regular telescopic front suspension, which doesn’t let you experiment with the set up. For a motorcycle that costs almost `8 lakhs on-road, it should have been equipped with upside down front suspension and Pro-link rear suspension, which would have improved the handing.
The CBR 650F is our runner-up in the two-wheelers segment. It scored a lot points in refinement, which is not surprising for Honda bikes. Even in terms of practicality, the comfortable riding stance helped the 650F nose ahead of the competition. But it lost out in value-for-money because the price of Rs. 7.30 lakhs (Ex-showroom, Delhi), which is a little high for its segment – as it enters the Kawasaki Z800’s turf. When it comes to safety, the 650F is equipped with effective twin 320mm petal rotor front disc brakes, a 240mm single petal disc at rear, and ABS. It’ll be a reliable product, which is a given since it’s a Honda. But the key here is that it can be racy while also being usable, which means that it offers quite a bit of value after all!


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Mussolini is invading Italy’s bookstores.
For weeks, Antonio Scurati’s “M,” a doorstop of a novel about the rise of the dictator, Benito Mussolini, has sat on Italian best-seller lists. The book is set to be adapted into a major television series by Wildside, the same production company that is co-producing the HBO series based on Elena Ferrante’s “My Brilliant Friend.” And this fall, it conquered Frankfurt’s book fair, where HarperCollins snapped up the English rights to the book.
“In the Italian imagination, Mussolini remains a kind of totem, a figure of great charisma, a kind of perverse national father whom we have repressed,” Scurati, 49, said in a recent interview. “This book has brought him out of that repression.”
The unexpected popularity of “M” has also provoked a debate in Italy on Mussolini’s legacy. Scurati’s cheerleaders says his book is a much-needed reminder of the evils of fascism, particularly for young people. But critics say the resurrection and repackaging of Mussolini for the 21st century presents dangers in a time when right-wing governments are being elected around Europe, including in Italy. (For what it’s worth, Jonathan Burnham, president and publisher of the Harper division of HarperCollins said, “it is compelling reading for anyone interested in 20th century history.” He called the book “a timely investigation of how fascism can take root in a society.”)


United Torah Judaism Jerusalem city councilmen have a new cause: shut down the capital's Har Hotzvim high-tech park and clear the area for residences. The haredi (ultra-orthodox) party is the largest party on the city council, with eight seats.
In a letter to Mayor Nir Barkat, party chairman in the city, Yaakov Halperin, said that the current location of the high-tech park was illogical because it is surrounded by residential neighborhoods, including Sanhedria, Kiryat Zanz, Ezrat Torah, Ramat Shlomo, as well as Ramot. "There is no doubt that a regrettable historic mistake was made in building the park in its present location. In retrospect, the person who decided on its location lacked sufficient forward perspective to realize that Jerusalem would grow and develop to the present situation in which the industrial park is in the heart of residential neighborhoods," Halperin said.
Halperin added, "We, the city's taxpayers, are obliged to do something to see to the future development of more residential areas, while allocating land for industry and high tech on the real edges of the city."
On behalf of the entire party, Halperin is demanding an urgent debate to "halt the development of the high-tech industrial park beyond its current size, to consider moving it in its entirety over the coming years, and most of all - to consider, for the sake of future of Jerusalem's economy, alternative and fitting locations for industrial parks. The park at Har Hotzvim is an environmental nuisance to the residents of the neighborhoods bordering it, including traffic and transport to and from it. It would be historic negligence not to stop this nuisance at the present stage and with a proper view to the future."
Councilwoman Rachel Azaria responded to the initiative with an urgent letter to Barkat and Prime Minister Benjamin Netanyahu. "The double standard of the haredi politicos, who on the one hand claim that there are no jobs for their constituency, while on the other hand seek to close the most important jobs in the city - is unmitigated hutzpah," she said.
Hiddush for Religious Freedom and Equality director Rabbi Uri Regev said, "Every time that we think that haredi conduct cannot make greater hallucinatory and outrageous demands, they prove just how naïve and lacking in imagination we are. A party in the municipal government that is demanding the removal of two of the city's most important workplaces can only be considered as a Trojan Horse. Before haredi politicians destroy this place, which is one of the most important industrial zones for the haredi community as well, they should get manna from heaven."
Har Hotzvim tenants include Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA; TASE: TEVA), Intel Israel Ltd. Amdocs Ltd. (NYSE: DOX), NDS Ltd., RAD Data Communications Ltd., and many other companies, including start-ups and technology incubators. Founded in the 1970s, the 530-dunam (132.5-acre) high-tech park currently employs 10,000 people in 310,000 square meters of built-up space.
The Jerusalem Development Authority plans to expand Har Hotzcim to add 5,000 jobs over the coming years. The development plan includes the construction of more space for current high-tech companies and space for new ones.
Haredi groups in Jerusalem have targeted Har Hotzvim in the past, especially Intel's fab on the site, which operates on Saturday. Some of the protests at the site, demanding that the company stop work on Saturday, were violent.
The Jerusalem Municipality is unconcerned by the latest initiative. It said, "The request is groundless, contravenes the municipality's policy, and the mayor rejects it out of hand. The municipality's policy is the opposite and supports the expansion of industry in the city. Har Hahotzim is about to be expanded to take in more large companies. The park is an important component of Jerusalem's economic strength and creates many jobs and livelihoods for the city. This trend will grow."
Published by Globes [online], Israel business news - www.globes-online.com - on July 14, 2011
© Copyright of Globes Publisher Itonut (1983) Ltd. 2011


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mind and body(redirected from Mind-body dichotomy)
Also found in: Dictionary, Wikipedia.
mind and bodyAn association long regarded as a Cartesian duality of disparate entities, after the work of Rene Descartes (1596–1650) but now recognized by most medical scientists as aspects of a unity. The prevailing view, today, is that the manifestations of the mind are wholly the result of neurological (mainly brain) activity and that, given sufficiently detailed knowledge of the structure and function of the nervous system, the association between function of the nervous system and corresponding mental capacity will be seen to be complete. Mental processes involve widespread brain function and are not localized to single brain areas. The existence of the mind body problem has been dismissed by some philosophers, especially Gilbert Ryle (1900–76), as an example of a category error.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

domain: psychology


Teengirl Fantasy. Awesome electronic music, hilarious website and this awesome music video for their song “Hoop Dreams” Party paradise!
Neil Gaiman talks audio books →
Neil Gaiman (Sandman, American Gods, Stardust, Nevewhere) is one of my favorite authors. Here you’ll find NPR audio clips of him talking about audio books with David Sedaris and Martin Jarvis. On top of that, he also shares some pictures and answers some of his fans questions on the page. He’s such an awesome dude! Hope he does more radio for NPR.


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June 21, 2016
Why You Should Go Through Travel Blogs
Sites that offer information to people on places they can visit during their holidays are known as world travel blogs. In order for people to find a place more attractive thus have the urge to travel there, photos of the destination are usually attached. There are as well suggestions of places in which people can find accommodation while in their destination. People who posses travel companies normally own these blogs. They enable people to get a variety of places to select from.
A good travel blog should focus on all the areas people would like to visit across the world. One specific area should not be concentrated on ignoring the rest. People get to have a variety of options. People should not forget to include the cost of travel as well as the directions to the places in the blogs. This makes it easy for people to plan for their journey. Because people will have knowledge of the directions to their destinations, they get to reach there fast. This prevents people from getting lost while on their way. As a result, they get to spend less in search for directions.
People should be given a list of activities to take part in while at their travel destinations. With this; people get to maximize their time. They also leave the place having tried out all the fun activities. People therefore get to have an enjoyable time during their travel experience. People should be told on the precautions to observe while at a particular place. People travelling to these destinations get to avoid accidents as a result.
Trips – Getting Started & Next Steps
People also get to embrace the spirit for adventure through these travel blogs. Local and international tourists will all be encouraged to visit the place. The blogs showcase the experiences of other people. Other people get to develop an interest in visiting the place. The tourism industry gets to grow as a result. Information on the blogs should be made precise for people to easily read through.
Practical and Helpful Tips: Blogs
Travel blogs also enable people to discard any fears they may be having about visiting a particular destination. People can get reliable information by going through the sites. For areas they are not sure about, they can always find clarifications. They also get to get rid of misconceptions that may be stated about some places. Facts about the places are therefore found.
Travel bloggers are required to avoid making exaggerations concerning some destinations. They should always give factual information that is reliable. Through this, people get to make appropriate choices on places to visit. There are many world travel blogs on the internet from which people can get this information In order to confirm the information given, people can go through many travel sites which highlight on a particular place. Having a world travel map enables people to have fun travelling around the world.
June 21, 2016
Steps and Process to Start-up a Good Multi-level Marketing Business
Network Marketing also associated to as Online Marketing, is a unique platform of selling using direct sales where payment for the work done is on the basis of product sold by its members and as for the sales brought about by the efforts done by other members that are in the business. Things and ways that has to be taken into consideration in this type of business are very vital in getting things done and desired objectives achieved.
It is of great significance and value to recognize that in achieving profound triumph in Multi-level marketing business, mentoring and coaching from veterans in the networking commerce works effectively if we adopt their ways and put it into practice, use the methods learned and clone those systematic routines once you have mastered it all.
You always have to mind set your members’ way of thinking to be in balance with your orders and prescription making sure it is being done accordingly and constantly showing them your leadership at all times to achieve winnings in this business.
Valuable Lessons I’ve Learned About Businesses
Always make it a point to let your people enjoy while in the business for them to stay for it will be of great help to your number of recruits that eventually will also improve your financial profitability since financial compensations are based just the same from their earnings not solely from your personal efforts on sales.
The Ultimate Guide to Services
The ever changing system and process in the Networking business has always been constant and updating, one you should always spend some time with your people and recruits as to keeping them abreast about the products you are selling and good effective business habits that needs to be adopted to greatly improve individual performance and as a whole.
It is important that you should know how to maximize, search for resources and consider available potent sales tools and other communication media platform to be applied among your workforce to get advancement in marketing skills and produce a large and wide range of prospects and customers. There are different effective and powerful ways to have your brand and product be recognizable to prospects and consumers by choosing and finding a proper place to market your goods and work with a credible and respectable entity that could bring your business and your product to a rank raise level.
One effective way of marketing your business and product produce is by simply recognizing the power of virtual awareness like setting up a website that could give and provide detailed information about your business and brand. The key to succeed in Networking and Multi-Level Marketing field can be challenging in some ways as it requires attention and one should have a strong desire for success and achievement to further gain convincing rewards in the end.


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Nurse Opens Hospice For Abandoned Senior Dogs Left To Die Alone, Treats Them With Ice Cream At The Beach During Their Last Moments
On 22nd December 2020
Nicola used to work in an animal rescue, she has opened a hospice at her home where she takes in abandoned, terminally ill, or senior stray dogs who are left to die alone. She makes sure the dogs go to the beach, eat the ice cream, and have their own birthday party. "They just want to feel loved and safe. I really believe they should get a nice ending."
Dogs deserve all the love in the world and this woman is on a mission to make this a reality
Nicola Coyle used to work in dog rescue and is now a retired nurse. This kind soul is on a mission to make every dog has the best possible ending. Nicola makes sure each and every dog that comes to the hospice gets a delicious steak dinner, a trip to the seaside, and also of course a birthday party.
She and her team make the final moments of the dying dogs precious
Nicola founded The Grey Muzzle Canine Hospice to take care of all those senior dogs that are abandoned, terminally ill, or stray.
Nicola doesn't want any dog to die feeling unloved, she wants their final moments to be the happiest and that they depart from this world with all the love they truly deserve.
So many dogs out there are left to die lonely and sad
According to an article from Bored Panda, Nicola runs the animal shelter from her own home in Mansfield, Nottinghamshire.
This amazing woman treats dogs with kindness and provides them with a quality life. She have them enjoy, play and have all the fun and just like this, these pure souls depart from this world.
The hospice treats the dogs like royalty
The senior dogs come to the hospice from various places such as kennels, vet surgeries, or charities where they risk being put down within seven days if they are not re-homed.
At the hospice, the dogs are treated like royalty given all the attention in the world. Each dog has a bucket list that the dog has to tick off. The list includes taking them for ice creams on the beach and throwing them birthday parties.
"I don't know when their birthdays are so we throw all of them a birthday party," she said. "They just want to feel loved and safe. I really believe they should get a nice ending."
Nicola spends on the dogs from her own pockets
Around £500 ($664.20) is spent on each dog from the former nurse's own pocket. Besides that, funds collected are also spent on the dogs to make their endings very happy and memorable. The steak dinner at the local pub and a trip to the seaside plays a major role in making the dogs happy.
If you want to contribute to this emotional cause, then donate here.
According to ABC News, many dogs even get to ride a police car or go to a McDonald's drive-thru.
Nicola has many dogs at her house, she not only takes care of them but also looks for foster homes for them
The bio of their official Facebook page says;
We provide end of life care for abandoned dogs. We take only dogs that are from UK pounds that have been deemed as having less than six months to live.
According to Animal Channel, it was also seen that most of the dogs ended up living more than they were supposed to as a result of the love that Nicola gave them. The shortest period that a dog has lived for, in the hospice, is two weeks, and the longest is surprisingly one year.

domain: pet


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At the fifth annual Cajun Code Fest Hackathon, a gathering of local coders will use open-source public data to develop apps and software that can improve the delivery of public services. Also on the slate for this year’s three-day tech crunch is the inaugural Smart Community Summit, held all day March 30 and convening several notable speakers on the topic of tech-aided city services.
Recently, Lafayette has received two grants to fund the development of “smart cities” solutions in the public realm. Announced earlier this month, Mozilla's Gigabit Community Fund made available $150,000 to Lafayette-based nonprofits looking to leverage the city’s fiber-optic network to enhance education in town.
Late last year, the U.S. Environmental Protection Agency awarded the city $40,000 to acquire air quality sensors and deploy them around the city, capturing data sets that are publicly accessible.
Initiatives like these are part of a broader national movement toward using tech solutions to assist the provision of public services and promote transparency. Advocacy groups have taken to calling communities that adopt these strategies “smart cities.”
The summit’s keynote speaker, Dr. Nishal Mohan, represents U.S. Ignite, one of the most prominent national organizations promoting smart city work. U.S. Ignite, which works with the Mozilla Community Fund, recently named Lafayette to its list of Gigabit Communities, a distinction that came with the $150,000 line of grants Mozilla made available. Jenn Beard, of the Mozilla Foundation, is also set to speak at the summit.
Mayor Joel Robideaux and other city representatives will be on hand for a panel discussing Lafayette’s recent advances in the smart cities field. Robideaux’s interest in hitching Lafayette up to the smart cities movement garnered an invitation to speak at Austin’s SXSW conference, where he delivered a short presentation on Lafayette’s smart cities work at an event hosted by U.S. Ignite.
Cajun Code Fest 5.0 runs through April 1. Coding teams compete off- or on-site at the Picard Center, vying for a top prize of $10,000. The Smart Community Summit begins at 9:30 a.m. March 30 at Abdalla Hall.


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And on June 7th, 2011, you'll be able to pick up Shadows of the Damned on Xbox 360 and PlayStation 3, an upcoming game from Grasshopper Manufacture of Killer7 and No More Heroes Fame. Like Alice, it'll also pit you against horrors in a dark, disturbing environment.
Should be a bright and cheery summer!
If you buy something through this post, IGN may get a share of the sale. For more, learn more.


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Drive Token SAFE DRIVE THE NEW CRYPTOCURRENCY SAFE DRIVE THE NEW CRYPTOCURRENCY 100% COMMUNITY DRIVEN Community driven & fair launch. Locked for 2 Years before launching first stock exchange. AUTOMATIC LP Every trade contributes toward automatically generating liquidity locked inside PancakeSwap LP. RFI STATIC REWARDS Holders earn passive rewards through static reflection as they watch their balance of DRIVE Token grow indefinitely. SafeDrive Auto generating liquity protocol Static farming by holding 0xa321fc1171eb85498fad47d3d127368eba70265c What is DRIVE Token? Watch the Video and get all the Information you need! WHITEPAPER 1. WHAT IS DRIVE TOKEN? DRIVE is based on the BNB platform and is a so-called BSC token. The maximum availability is: 210.000.000.000 DRIVE A new crypto currency based on BNB smart chain. 4% of each transaction is always distributed to all holders as a reward. Thus, the personal wealth increases automatically with every purchase or sale. In addition, 4% is donated to the network.
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Services for Astley & Tyldesley:
covenant service led by Len Pereira
Morning service led by Sue Whitehead
Morning service led by Alan Eaves
Circuit streamed service
Morning service led by Neil Whitehead.
popular recent storiesAlso in the news
Atherton Central are delighted to announce that we are resuming Coffee Morning from Thursday 24th June 2021 between 9.30am and 11.30am (socially distanced of course) and weather permitting some outdoor seating.All are welcome and we look forward to welcoming you...


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In a battle for playoff position and seeding, the Rangers vs Penguins matchup stands out as a marquee game on a very good NHL Tuesday slate. Pittsburgh currently clings to a one-point lead over the third-place Rangers, but by the time the final horn sounds, these teams could flip-flop spots within the Metropolitan Divison.
Both teams are coming off a game against extremely inferior opponents, and while they both won their previous game, the Penguins did so via an 11-2 annihilation of the Red Wings. It took New York overtime to get past the Sabres.
Let’s take a look at the NHL betting odds, trends and picks for the game and give our Rangers vs Penguins prediction.
Rangers vs Penguins NHL Betting Preview and Prediction
NHL Regular Season
New York Rangers (42-19-5 20-13-2 Away) vs. Pittsburgh Penguins (40-17-10, 19-9-5 Home)
Date: Sunday, March 29, 2022
Time: 7:00 p.m. EST
Venue: PPG Paints Arena – Pittsburgh, PA
It doesn’t take much analyzing this Rangers vs Penguins game to realize it is likely going to come down to goaltending. Tristan Jarry has been very good for the Penguins all season and should rightfully be on the outskirts of the Vezina Trophy consideration. Shesterkin has been phenomenal for the Rangers, locking up the Vezina Trophy weeks ago. Both teams enter the contest allowing the exact same amount of goals per game, at 2.58. That is the third-best in the NHL.
For playoff-bound teams, games this time of year start to mean more. They start to matter more. They start to elicit more effort. This game feels like it will be an all-out battle from the crease through the goal line in both directions. It will be interesting to see how quickly the Penguins can lock in after coming down from the high of scoring 11 goals.
If that is indeed the way the game goes, a six-goal total provides plenty of cushion. Some books have already lowered it to 5.5 around the same -120 number, so we advise acting quickly if you like the under as a play.
Rangers vs Penguins NHL Betting Odds & Spread
Moneyline: NYR: (+145) | PIT: (-165)
Puck Line: NYR: +1.5 (-175) | PIT: -1.5 (+155)
Total: 6 — Over: (EVEN) | Under: (-120)
Team Totals: NYR o2.5 (-120) / u2.5 (-110) | PIT o3 (-145) / u3 (+110)
Public (Spread) Betting via Action Network: NYR: (37%) | PIT: (63%)
Odds to Win Stanley Cup: NYR: (+2000) | PIT: (+1600)
Rangers vs Penguins NHL Betting Trends
– New York is 33-33 (50%) ATS this season
– New York is 26-39-1 (40.2%) to the Over this season
– Pittsburgh is 33-34 (49.3%) ATS this season
– Pittsburgh is 32-32-3 (50%) to the Over this season
Rangers vs Penguins NHL Stats
– New York averages 3.02 goals per game (GPG) this season (No. 18 in NHL)
– Rangers have surrendered 2.58 GPG (T-No. 3 in NHL)
– Pittsburgh averages 3.31 GPG this season (No. 9 in NHL)
– Penguins have surrendered 2.58 GPG (T-No. 3 in NHL)
– New York has a goal differential of +31 in 66 games this season
– Pittsburgh has a goal differential of +46 in 67 games this season
Signup for BetUS Sportsbook today for a 125% Bonus up to $2,500!
Rangers vs Penguins Prediction
Our Rangers vs Penguins prediction is pretty simple. This game will be a hard-fought, close contest between two very good teams. The goaltenders will not face a lack of shots, but will be up to the task on almost all of them. The first team to score three goals will likely win this game. Lock in the under six while you can.
Our NHL betting Rangers vs Penguins prediction tonight will be Game Total Under 6 at BetUS
For what it’s worth, numberFire gives the Penguins a 61.4 % chance to win.
Rangers vs Penguins Prediction and Picks
Game Total – u6 (-120)

domain: game


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Brown water flows out of taps in 50 Punggol blocks
SINGAPORE — Residents in 50 blocks in Punggol received a shock when they turned on their taps this afternoon (June 12) and saw brownish water running out. However, the national water agency PUB said the discoloured water is safe for drinking.
In a press statement, it explained that the discolouration was caused by sediments in a water pipeline that were stirred up during valve operations it carried out at noon today. These sediments are actually minerals in tap water that settled down over time in the pipes, it added.
The PUB said the valve operations were carried out on a transmission water main along the Tampines Expressway in preparation for the connection of a newly-laid pipeline.
After it started receiving reports of the discoloured water at 2pm, the PUB sent teams of officers to the area to flush the mains. The officers also went home to home of affected residents to flush their service pipes.
It added that the water will clear after leaving the taps running for a while.
The PUB also deployed two water tankers and water bags to provide temporary water supply to those affected.
For feedback, members of the public can contact PUB’s 24-hour call centre at 1800 284 6600.


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Massive DisneyLand Attraction Database
The Yip and Sail's Smokehouse show as seen from the top of the woods
Yip and Sail's Smokehouse
July 23, 1968
Avg. queue length:
Nobody is sure what the appeal of Yip and Sail's Smokehouse is. It was once a fun place with things to climb, but the legal staff had it confiscated to make it harder for kids to get exercise.
- If traveling with impatient children, you may want to promise them candy before getting in this queue.
- Expectant grandparents should use the restroom first.
- Your children will want to ride this over and over.
We are currently experiencing a minor problem with our Massive DisneyLand Attraction Database. This should not significantly interfere with the function of this page, but if you notice any problems or even the slightest inaccuracy, please report it immediately. Thank you for your patience.

domain: travel


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Time has chosen Joe Biden and Kamala Harris as persons’ of the year.
US, Biden administration to hand out 100m vaccinations all over US during the first 100 days of presidency.
Healthcare officials have warned staff and facilities in the US are struggling to cope with this unprecedented crisis.
Trump labelled Twitter a national security threat after #DiaperDon went viral following a news conference in which he reiterated claims of election fraud.
Donald Trump has allowed the transition of power to begin begin for Joe Biden. The Democrat nominee was declared the “apparent winner” of the US election.
Trump has made his first official public appearance by visiting the Arlington National Cemetery on Veterans Day.
Several people have been injured in an Islamist bomb attack at a Remembrance Day ceremony attended by foreign diplomats in Jeddah, Saudi Arabia, French authorities have confirmed. Remembrance Day Terror Attack The French foreign ministry stated that an improvised explosive…
Officials in Japan have warned of an upcoming third wave of Covid infections as cases rise as a result of colder weather and a government campaign encouraging tourism. Japan expects third Covid wave The number of daily Covid cases is…
Joe Biden is set to become the 46th President of the United States on January 20, but Trump won’t accept his loss.
Joe Biden becoming President of United States means pets will finally return to the White House, meet ‘Champ and Major’ the new ‘First Dogs’.
Singles Day 2020 is on November 11 and is the biggest 24-hour online shopping event.
Joe Biden is looking forward to enter the White House and start ruling the country.
Some countries registered higher numbers rather than others: US, India and Brazil are among the worst-affected.
Joe Biden has been elected President of the United States of America: the Democratic candidate will lead the White House for the next four years.
The 17-years-old climate activist’s mockery about the Trump’s request to stop counting of votes.
The Prime Minister Giuseppe Conte announced the new measures: the restrictions will be rather severe for these four regions.
Sarah McBride has officially become the first openly transgender state senator in American history.
Protesters clashed with police officers on Election night near the White House and others marched the streets with anti-Trump placards.
The candidate with the most votes might still lose, but why? Here’s how the US presidential election works.
Two men and a woman were shot dead and 15 injured in Vienna terror attack on Monday.
The 42-years-old is stuck in Iran since a holiday in 2016, her ‘mental torture continues’ as Iran excludes UK from attending trial.
A strong earthquake struck the Aegean Sea on Friday and both Turkey and Greece were deeply hit.
On 28 October French President Macron will speak to the nation. It is said that he will announce a national blockade, as the cases of Covid increase.
Trump was at a rally in Pennsylvania yesterday when he claimed his son Barron had ‘the China virus’ for 15 minutes.
A week before the US election, the Senate confirms Judge Amy Coney Barret to the Supreme Court.


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More Success Stories >>
Lee County School Gets Grant
Bonita Springs Middle School in Lee County was recently awarded a Lowe’s Toolbox for Education Grant totaling $4,565. Funds from the grant will be used to enhance the school’s Edible School Yard Garden with the purchase of plants, mulch, gardening tools, carts and fertilizer. Students and school staff have created an innovative edible outdoor classroom where hands-on activities and lessons aligned with the Sunshine State Standards are taught. Individuals interested in touring the garden or to learn about the Edible School Yard Garden program can contact Bonita Springs Middle School at (239) 992-4422.

domain: agronomy