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Having beautiful flower beds doesn't have to be just a dream. I have found many frugal ways to fill my gardens with perennials, bushes, and trees.
Swapping: Everyone has something they are eventually going to divide in the garden to keep them neat and tidy. Contact all of your friends and inquire if they would like to swap some of your perennials that you have divided for something in their garden. Make sure anything you bring home is put in the ground immediately, along with some compost material, water, and fertilizer.
Contact your local Gardening Club: Your local club can be a wealth of information and valuable resources! Usually they are working with native plants and flowers and could give you expert advice and also lead you to great plant resources available at a much better price.
Your Local Dump: Amazing but true...people throw away some of the nicest plants into the compost heap at the dump. A little loving care for a week or less could show great improvement and soon you will be looking for a home in your garden for them. Grab some compost while you are there, it's normally free!
FreeCycle.Org: Place a want ad for perennials, bushes... anything, in FreeCycle.org. So many people thin their bushes or divide their perennials and this could be a wonderful place to find interesting plants to add to your garden. Ask if anyone is willing to give you cuttings to root or new shoots from bushes so you can give them some tending for your own home gardens.
Supermarkets: I like to check out behind big supermarkets as usually once a week they take all of the plants that are drying out and limp and throw them away. Usually you will find them in a heap somewhere out back. I also ask the store manager if I can help myself when they decide to throw away large amounts of plants. Most do not care if you would like them, especially if you are a customer.
Local Wildflowers: One of my favorite hobbies is to take walks looking for wonderful native flowers that I can use in my bare spots or in areas of the yard that need fillers. Each state has dozens and dozens of the most gorgeous and underappreciated flowers. The only thing you want to do is find out how evasive they are. Some you may want to plant in places you do not mind the spreading. Most are just perfect in any garden for a natural wildflower addition.
Seed Swapping: In the winter I like to do seed swaps with friends and family. Everyone has leftover seeds they did not use the year before and you may have some also. It's a great chance to try your hand in the spring at starting some new varieties. All you need is a place in the sun somewhere in your home to start in early spring!
Editor's Note: If there are laws against it in your area, do not do it. Also digging of native plants may be prohibited. Be sure to check your local laws. If you know the owner of the property always ask before picking or digging anything.
In the UK its illegal to pick wild flowers let alone dig them up - so may people used to do so we have lost many native species. As for taking plants from empty or abandoned properties - that would be called stealing here!
And in parts of Canada too. On most public land you are expected to take only pictures. Leave only footprints.
I agree wholeheartedly with the other 2 responses! DON'T STEAL wildflowers or plants from ANYWHERE! What if everyone stole plants from forests and public lands? You should try to leave as tiny a footprint as possible; NOT steal whatever you can get your hands on.
You also must be careful to ask BEFORE taking anything from a store's property. Many do NOT want customers rooting around in their dumpsters, etc. They would rather have you purchase the good plants they have for sale and not make a mess behind the store. You could be prosecuted even if it is technically in the garbage.
I add 2 positive tips:
1. Be sure to look at and identify what you have BEFORE pulling plants as a weed. It may be a pretty wildflower if left to grow so look up the plant before you pull out and throw into the compost heap. If you can't identify it online; try leaving one to grow and see what it becomes.
I've relocated a number of plants to dedicated garden areas. What once looked like a mess is now a pretty patch of Forget Me Nots, RoseRoot, wild geraniums, etc.
It's a GREAT way to diversify your garden and you already know the plants will grow well in your yard's conditions.
2. Look for end of season clearance sales. You can plant just as well in the fall. I often find plants at 75% off or more at the end of the summer. Just plant them and water as usual (don't fertilize until spring as it may fry the root system) and mulch well for the winter.
Share plants with friends, shop sales, look at public compost heaps but NEVER steal plants from any lands public or private!
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domain: agronomy


Bell, part of American conglomerate Textron, has released a 1:01 minute video animation of its new helicopter that develops for the U.S. Army’s Future Attack Reconnaissance Aircraft (FARA) competition.
The animation shows that the new Bell 360 Invictus helicopter offers exceptional speed and agility to perform in the highly contested battlespace.
Showcasing the Invictus’ combat capabilities, the video goes on to show animated footage of the helicopter attacking enemy targets, including the newest Russian-made T-14 main battle tanks and T-15 heavy infantry fighting vehicle based on the Armata heavy tracked standardized platform.
The new Russian T-14 tank was shown to the public for the first time at Red Square’s Victory Day parade on May 9, 2015. The new combat vehicle features fully digitized equipment, an unmanned turret and an isolated armored capsule for the crew.
The deliveries of the armor based on the Armata combat platform to the troops for operational evaluation will begin this 2020, according to CEO of the Uralvagonzavod defense manufacturer Alexander Potapov.
“In 2020, we will begin the deliveries for the operational evaluation of this armor. During the factory tests, all the vehicle’s stated characteristics were confirmed,” the chief executive said.
As to the Bell 360 Invictus, the aircraft is designed for speed, with the Army calling for a cruise speed of 180 knots, and a maximum of 205 knots. With this in mind, every element of the Invictus has been chosen to reduce drag as much as possible, including its tandem cockpit. This, combined with its high-speed rotor, with a design borrowed from the upcoming 525 Relentless super medium civil helicopter (which has gone above 200 knots in flight tests), has Bell confident it can meet the Army’s requirements.
This advanced aircraft will have a transformative impact through next-generation flight performance, increased safety and greater operational readiness—all to deliver decisive capabilities.
It’s also worth noting that Invictus aircraft a maximum rotor diameter of 40 feet, allowing it to sneak down city streets and hide behind small obstacles.
Also, the Bell 360 Invictus supports a 20mm cannon and internal payload that features an integrated munitions launcher to accommodate current and future ordnance. The combination of advanced sensors and air-launched effects elevates situational awareness and increases lethality across the multidomain spectrum.
— Bell (@BellFlight) February 24, 2020


LATEST ALOK SHARMA NEWS AND BUSINESS UPDATES
Housing Minister Kelly Tolhurst resigns after 'devastating' family news as Boris Johnson says he is 'very sad' to lose the 'brilliant minister'
Housing Minister Kelly Tolhurst shared her letter of resignation last night which explained she was stepping away from her role after receiving 'devastating' family news.
Changes will enable homeowners to extend their leases up to 990 years at zero ground rent, but how will they work?
Why is the Coronavirus vaccine taking so long to deploy? As Boris blames regulators for a sluggish start, fingers are also pointed at bureacratic hurdles for volunteers and a shortage of vials
Worldwide demand for glass vials is just one of the factors behind the slow pace of coronavirus vaccination in the UK. Drugs firms warned about a potential shortage as far back as May.
Dumb Perignon! Housing minister who should be sorting out the cladding scandal is too busy reviewing champagne
A minister whose department is supposed to be tackling the cladding scandal has advised voters to glug £174-a-bottle champagne while awaiting the rollout of the Covid vaccine.
Return of The Saj! Former Chancellor Sajid Javid is set for new Cabinet role helping to lead Britain's recovery from coronavirus pandemic
Sajid Javid, 51, is set to make a Cabinet comeback in reshuffle later this year. The ex-Chancellor is in the running to replace the Business Secretary in a key role to help Britain's recovery from pandemic.
A shortage of doses, red tape strangling volunteer army, and a row over second jabs: DAVID ROSE asks if this will be the vaccine of freedom - or another fiasco in the making?
Far from having millions of doses of the coronavirus vaccine ready to roll out, it has emerged that there are just 530,000 ready for the programme to begin on Monday, writes DAVID ROSE.
How workers could take up to 93 DAYS of holiday in 2021 by rolling over untaken annual leave thanks to the government's Covid ruling
Employees who have left any of their statutory annual leave entitlement untaken whilst home-bound by covid-19 restrictions this year are now entitled to carry it over for two leave years.
Death of the gas boiler: Ministers plan ban on new home connections to the gas grid from 2025 in favour of hydrogen and heat pumps as all homes must have 'C' energy performance by 2035 under Boris Johnson's green energy revolution
Boris Johnson's green energy revolution could spell the end of gas boilers in new homes from 2025 as the Government aims to replace them with hydrogen and heat pumps.
Energy firms are told to make loyalty pay: Customers are in line for big savings as they will no longer be punished for staying with their regular supplier
Business Secretary will announce today that energy customers will no longer be punished for their loyalty under plans that could save households hundreds of pounds a year.
Ministers are planning crackdown on 'rip-off' energy firms over expensive penalties for loyal customers
Business Secretary Alok Sharma is expected to announce moves to stop energy companies from punishing longstanding customers with expensive tariffs - known as the 'loyalty penalty'.
Alok Sharma's vaccine army: How Bomb disposal hero led crack team to make UK first in world to roll out jab after opting out of EU's slower efforts
Lieutenant Colonel Nick Elliott, a former combat and bomb disposal engineer in the first Gulf War, the Balkans and Iraq, was handed operational control of the Vaccine Taskforce in April.
Business Secretary Alok Sharma met Prince Charles days after staff member in Cabinet minister's private office tested positive for Covid
Business secretary Alok Sharma met the heir to the throne last Thursday, a week after a meeting involving a member of his private office who later tested positive for the disease.
The Business Secretary yesterday defended the decision to continue with the visit to South Korea, with his spokesman saying he had tested negative for the virus before flying out.
Business Secretary Alok Sharma defends decision to continue South Korea trade trip where he met local politicians after staff member in his private office tests positive for Covid
The Business Secretary jetted to Seoul on Saturday October 24 for a series of meetings designed to boost trade relations between the two nations.
MARTIN SAMUEL: The last thing football needs is politicians without a clue... the Business Secretary doesn't even know what division Reading - the team in HIS constituency - are in!
MARTIN SAMUEL - CHIEF SPORT WRITER: Alok Sharma was on the radio last week when he encountered Paul, in Reading. Paul was a Reading fan. Sharma is the club's local MP.
Boris Johnson's cabinet is at war with split between Matt Hancock's lockdown-backing 'doves' and Rishi Sunak's 'hawks' who want the country - and its economy - left open
Ministers have been debating for three weeks whether to use Sage's advice for a UK-wide lockdown to beat back the virus. But the PM's opting for the three-tier system on Monday was different.
Council in London claims it was told to 'back off' forcing supermarkets including Sainsbury's to make sure customers are wearing face masks
Four retailers, Sainsbury's, Lidl, Morrisons and B&M homeware stores, were handed warning notices by Barking and Dagenham council in east London after officials saw staff failing to enforce the rules.
Space debris threatening to destroy the ISS and make low-Earth orbit 'too perilous for humans' will be tracked with the help of £1million funding from the UK government
Astronomers are concerned that high-value craft in low-Earth orbit, such as the International Space Station (ISS), could be destroyed by a rogue piece of debris.
Michael Gove played a key role in forcing through the rule of six at Covid cabinet meeting - and has 'been consistently on the side of the toughest approach', says source
Chancellor of the Duchy of Lancaster, Michael Gove, pictured, was determined to limit the number of people who could meet up in public or private to just six, despite the strong objections of colleagues.
Secret recordings and leaked files reveal how the Liberal Party allegedly used fake members and staff to amass political power - with one of Scott Morrison's frontbenchers at the centre of fresh branch stacking scandal
Assistant Treasurer and Housing Minister Michael Sukkar and former Defence Minister Kevin Andrews have been accused of using taxpayer resources to branch stack for the Liberal Party.
Grim warning of 'permanent damage' to Victoria as Daniel Andrews is slammed for shocking quarantine blunder that kickstarted Melbourne's deadly outbreak
Federal housing minister Michael Sukkar warned of 'permanent damage' caused by Melbourne's fresh lockdown which has shut all non-essential businesses for six weeks.
Almost 20 per cent of workers - six million people - are STILL on furlough: Only seven per cent left the scheme and returned to work in first half of July amid fears of massive layoffs
Roughly one in three furloughed workers in Britain returned to their jobs as the hospitality industry began to reopen after lockdown, the Office for National Statistics (ONS) said.
Business Secretary Alok Sharma overrode concerns of top official as Government bought £400m stake in failed satellite firm OneWeb
The UK is part of a consortium with India's Bharti Global which won a bidding war for the company, which went bankrupt earlier this year trying to develop a space network for broadband.
Robert Jenrick faces further planning headache back home as his constituents accuse him of failing to protect green spaces
Robert Jenrick's planning headaches won't disappear when he leaves Whitehall and returns to his Nottinghamshire constituency, The Mail on Sunday can reveal.
Tory rebels sink plan to ease Sunday trading laws to help retailers recover from the coronavirus lockdown
Plans to relax Sunday trading laws have been shelved in the face of mounting Tory opposition after ministers floated the idea of 'temporary' relaxation of rules to help retailers.
Housing minister Robert Jenrick 'viewed promo video for £1bn development on mogul's personal mobile phone' weeks before overruling his own officials to approve scheme
He watched the video happened weeks before Robert Jenrick overruled his officials and approved the project to redevelop Westferry Printworks into luxury flats in east London.
Tory MPs rebel as ministers rebuff 'vital' £1.3bn lagoon plan that could provide a huge post-Covid jobs boost
Boris Johnson is facing a backbench rebellion after blocking a tidal power scheme while sanctioning Chinese involvement in the UK's nuclear power programme.
Ministers set to usher in new laws to protect vital UK firms from foreign predators after China tech row - as business secretary Alok Sharma declares Britain open for investment but not exploitation
The legislation will give Business Secretary Alok Sharma extra powers to impose conditions on deals to protect key UK firms that have been left vulnerable by the Covid-19 economic crash.
Government is savaged over two metre rule as Alok Sharma insists it will STAY despite dire warnings it is crippling economy, stopping schools from reopening and could cost THREE MILLION jobs
The Business Secretary told tonight's Downing Street press conference that the measure - more strict here than anywhere else in Europe - was required for public safety.
The High Street reopens: Business Secretary Alok Sharma confirms non-essential retailers CAN open their doors from this Monday but refuses to budge from 2 metre rule businesses say is killing recovery
The move will provide a lifeline for businesses and workers who have taken a battering from the effects of coronavirus and provide a relief for weary consumers who have been stuck at home for months.
Alok Sharma tests NEGATIVE for coronavirus saving Boris Johnson and Rishi Sunak from potential fortnight in quarantine after their 45-minute meeting with him
The Cabinet minister spent today in self-isolation and working from home after becoming visible ill in the Commons yesterday. Tonight a spokeswoman said: 'He has received a negative result.'
Alok Sharma is STILL waiting for his coronavirus test results but is 'working from home' - as Boris Johnson and Rishi Sunak face a nervous wait to see if they have to self-isolate after their 45-minute meeting with him
The Cabinet ministers is well enough to work from home despite visibly struggling in the House of Commons yesterday, Transport Secretary Grant Shapps revealed tonight.
Business Secretary Alok Sharma gets muddled over coronavirus testing as he claims 115,000 people were screened yesterday - despite government not having released figures for a week
Alok Sharma was pressed in a round of interviews on figures ministers say show there is enough capacity in place to contact trace new coronavirus cases.
Humble pie? No, we got undiluted praise for his top adviser: HENRY DEEDES sees Boris Johnson going in to bat for Dominic Cummings
HENRY DEEDES: Standing at the podium, there was a permanently flustered air about him, like a man desperately trying to remember where he'd parked the damn car.
Jonathan Van Tam admits 'we may have to learn to live with' coronavirus for YEARS as Imperial College expert warns a coronavirus vaccine is unlikely before 2021 after ministers said they hoped to have it ready by September
The UK's deputy chief medical officer Jonathan Van-Tam said that without a vaccine Britons would have to 'learn to live with this virus' during Downing Street's daily press conference today.
So much for September: Imperial College expert warns a coronavirus vaccine is unlikely before 2021 and urges people not to have 'false expectations' after ministers said they hoped to have 30 million doses ready within months
Experts have warned a working coronavirus vaccine is unlikely to be ready this year as they told people not to have 'false expectations'.
Government WON'T vary lockdown rules across Britain - despite the R rate varying widely in different regions
Speaking at the latest Downing Street press conference, Buisness secretary Alok Sharma said the government would be sticking with its national approach to the lockdown for the moment.
Coronavirus vaccine 'by September': Oxford University strikes deal with AstraZeneca to produce 30 million doses of the jab - the moment it's proved to work
Britain will get first access to a coronavirus vaccine being developed by Oxford University with pharmaceutical giant AstraZeneca poised to make 30 million for the UK by September - if it works.
'Isolated' working, staged returns and canteen etiquette: Businesses reveal their plans to get back to work after lockdown - as ministers draw up 10 'granular' blueprints for each sector
Ministers are working on a series of workplace guides going into 'granular detail' about the measures that will have to continue even when the lockdown is eased, which now looks like it will not be until June.
Business Secretary Alok Sharma reveals almost 400,000 companies have applied to the government's furlough scheme in just three days at a potential monthly cost of £7bn as firms warn access to coronavirus loans must be speeded up
Alok Sharma today revealed almost 400,000 businesses have made applications to the government's coronavirus furlough scheme, covering almost three million workers.
Coronavirus vaccine will take 'many months' and 'there are no guarantees' one can be found, Alok Sharma admits as Number 10 announces first trials will begin next week - after hopes it could be ready by September
University of Oxford scientists are confident they can get jab for the incurable disease rolled out for millions to use by autumn.
Britain could suffer the WORST coronavirus death rate in EUROPE, higher than Italy or Spain, warns top scientist who says future outbreaks are 'inevitable' unless a successful vaccine is developed
Business Secretary Alok Sharma floundered when Sir Jeremy's comments were put to him on the BBC's Andrew Marr show. 'Different countries are at different stages of this cycle,' he said.
Home Secretary Priti Patel insists she has been working 'virtually every single day' on the fight against coronavirus as she faces her first daily press conference since the deadly outbreak swept the UK
Home Secretary Priti Patel appeared at the government daily coronavirus briefing today, the first time she has spoken at the briefings since they started on March 16.
The UK is well prepared to tackle coronavirus but, of course, businesses clearly face challenges in multiple areas. I know that many are concerned about the longer-term effects on investment.
Now Business Secretary is dragged into Sirius row amid fears ordinary shareholders will be shut out of vote
Alok Sharma has been urged to speed up a review of City rules that make it hard for individuals to take part in major company decisions ahead of the vote at Sirius Minerals next Tuesday.
Britain's record breaking jobs market will be put into jeopardy if Tory rebels vote down May’s Brexit deal, minister warns
Alok Sharma said ‘our jobs boost could become a jobs bust’ with firms cutting investment and laying off workers if Parliament fails to back the Withdrawal Agreement.
Minister chokes back tears as he tells MPs how meeting the survivors of the Grenfell Tower disaster was the 'most humbling and moving experience of my life'
Local government minister Alok Sharma became overwhelmed with emotion as he recounted the moving stories he has heard from those who escaped the blaze with their lives.
Furious Grenfell Tower survivor confronts housing minister over his family's need for a permanent new home after they lost everything in the blaze
Oluwaseun Talabi, who fled the 14th floor of the burning tower with his family, jumped up on the BBC's Victoria Derbyshire show and challenged housing minister Alok Sharma.
Meet the man who has to deliver a million homes in two-and-a-half years: So can Alok Sharma Britain's 15th housing minister in 20 years pull it off?
Responsibility for housing has now changed hands six times since 2010. So can the latest person tasked with the job, Alok Sharma, pull off the trick of getting enough homes built?


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Two dead as single engine plane crashes after takeoff from Whitehorse airport
By The Canadian Press
WHITEHORSE – Transportation Safety Board investigators are on their way to the scene of a deadly plane crash in Yukon.
Spokesman Jon Lee says a single-engine Cessna 170 crashed into trees moments after take off from the Whitehorse airport on Monday, killing the pilot and lone passenger.
The crash, barely 600 metres from the end of the runway and just west of several busy baseball diamonds, also sparked a fire.
Airport and city firefighters doused the flames with assistance from a helicopter dropping water from a bucket.
The privately registered aircraft had been on its way to Anchorage, Alaska, but the names or hometowns of the victims have not been released.
Lee says a TSB team should be at the scene by midday to begin what he calls the “long process” of gathering information that could assist the investigation.
“Collecting information on the pilot, the aircraft, the maintenance history, collecting weather information. If there was any closed circuit TV imagery at the airport we will try to get that,” Lee says.
He says the Edmonton-based team will also seek statements from any eye witnesses.

domain: news


text:
Down south of Metro Manila is Batangas province, where the tourist-loved San Juan is located. Famous for its clear water and white sand Laiya beach, the comfort promised in San Juan fits the ideal at-home life. Here, every minute feels like a vacation-type breather everyone has been dreaming of.
People who look for Batangas house and lots often target Lipa City or Batangas City for new listings. However, there are available units of better if not similar properties in San Juan. Rather than finding a house for rent, find house and lots in Camella San Juan. For a great price, bedrooms, kitchens, and living rooms of all sizes are available in our units.
Are you looking for a house and lot in San Juan, Batangas for sale? Find properties in Camella San Juan today!
Imagine welcoming the sun in a cozy home near the refreshing coastline of Batangas. Located in Brgy. Calit-calit, Camella San Juan exhibits a resort-like environment, an everyday life in a getaway setting, unlike other properties. This community boasts its Mediterranean-themed architecture with a touch of resort-living ambiance. This is on-brand with what San Juan is widely known for.
This neighborhood near the majestic coastline of Batangas has one-of-a-kind amenities. As a result, it increases each homeowners’ satisfaction living in their dream homes. Beyond the beautifully-crafted Camella house and lots are amenities such as a swimming pool, linear park, playground, and multipurpose courtyard. More than that, the community is safe and secured 24/7 with its roving and stationary guards.
Residents of Camella San Juan live every day enjoying the conveniences of infrastructure and new developments. These road conveniences connect Batangas to its neighboring provinces and key cities. In fact, the province benefits from its proximity to the country’s capital and center of business, Metro Manila. But on top of these, there are also overflowing opportunities available within the Batangas borders. Added to the influx of tourists in the majestic natural wonders in San Juan, life in the well-crafted homes within Camella San Juan is the future everyone aspires to have.
If you are looking for a house and lot in San Juan, find properties in top locations like Camella San Juan. Kindly contact us for more inquiries.
Located at Brgy. Calitcalit, San Juan, Batangas
Camella Home Series
TCP: Php 5.4M
Floor Area: 53 sqm.
Min. Lot Area: 88 sqm.
2-Storey Single Firewall, 2 Bedrooms, Living Area, Dining Area, Kitchen, 2 Toilets and Bathroom
This is the life waiting in Camella.
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domain: geography


text:
The best way to eat fruit is fresh, ripe and straight from the tree. But what are the options if that’s not possible?
Across Western Australian fresh quality fruit is seasonal and good quality ripe fruit only lasts a few days at its peak. Our dried fruit products have all of the nutritional and health benefits of fresh fruit.
Our low temperature drying process ensures that the vitamin and antioxidant properties of the fruit remain. We only remove the water, and leave all of the fibre, vitamins and minerals intact. Drying preserves the fruit, without any added sugar or preservatives, making our products ideal for people with sensitivities to food additives and allergies.
Southern Forests Flavours creates compact, transportable, nutrient packed snack options, perfect for a busy lifestyle.
We are in the process of becoming HACCP certified.

domain: food


text:
HMSI’s first in-house developed model is seeing an overwhelming response. The Honda Navi‘s surging demand has led the company to ramp up the planned production.
Expected to arrive in early 2017. The 2017 Citroen C3 Picasso didn’t show-up at the 2016 Paris Motor Show against expectations as the company is.
Will be launched in late-2017. A spy video published on YouTube channel luxuryliveson shows the 2018 BMW M5 testing in the US. [Direct Youtube link].
To be based on the AMP architecture. According to a report on the Economic Times, Tata Motors will soon start focusing on the premium hatchback.
The A4 is currently available only in petrol in India. Thrustzone has acquired spyshots of the Audi A4 diesel variant testing without any disguise. The.
Joins the CB190R and CBF190R in Honda’s sub-200 cc range. Honda has unveiled the new dual-sport motorcycle, Honda CBF190X, at the 14th China International Motorcycle.
Will be made at the Piracicaba plant in Sao Paulo. Hyundai of South America has released more teasers of the South American market Hyundai Creta, which.
Will go on sale in February. The UK-spec 2017 BMW 5 Series‘s pricing and specifications have been revealed in the car’s ordering guide that has.
Yet to receive confirmation from VW India. According to new web reports the range-topping VW Polo GTI hot hatch will launch in India next month..


The EL-MOTE-DULT+ is a high-accuracy, dual-channel, Cloud-enabled wireless ultra-low temperature data logger, designed for monitoring vaccines in cryogenic dry ice storage. The measurement range is -100 to +100°C (-148 to +212°F) using the probes supplied with the logger. The logger automatically records data and uploads it to the EasyLog Cloud via your normal wireless network.
EasyLog Cloud harnesses the power of IoT to automate data logging and alert notifications - perfect for both compact systems with just a few sensor requirements to corporate solutions with thousands of devices around the globe.
Manage multiple data loggers in locations around the world and view them using your Internet Browser or EasyLog Cloud App. The EasyLog Cloud offers unlimited & secure data storage, advanced alarm notifications to multiple users and powerful analysis and reporting from all your devices. Plus the first data logger on your EasyLog Cloud system is FREE.
This product complies with BS EN 12830:2018 (Temperature recorders for the transport, storage, and distribution of temperature-sensitive goods).


The image shows the surrounding of the Trapezium cluster at the center of the Orion Nebula. The strong radiation of those stars vaporizes the dense dust clouds that begin to form young stars and planetary systems. The image shows a couple of these Proplyds (marked).
Meade 16" AFC 400mm @f/10, 10Micron GM2000 mount
SBIG ST 2000 CCD camera @-15°C
LRGB 4x300s+8x30s+8x10s+6x3s/3x180s+2x60s/2x180s+2x60s/3 x180s+2x60s; RGB 2 x 2 binned
Location: Sahara Sky Hotel, Zagora, South Morocco
North is on the right side of the image


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Gay and lesbian couples may choose surrogacy as an alternative to pregnancy or adoption. Surrogate mothers carry a child with the sole intention of allowing the gay or lesbian couple to adopt the child(ren) after birth. There are legal issues associated with surrogacy, which means gay and lesbian couples may need to seek the counsel of an attorney to draw up legally binding paperwork and address legal issues along the way.
It is important for the gay or lesbian couple to discuss every angle of surrogate parenting before searching for an available surrogate mom. Personal issues like methods of conception, legal adoption and feelings associated with potential birth defects and loss of pregnancy need to be addressed on a personal level between the couple before legally binding documents are signed.
Methods of Obtaining a Surrogate Mom
There are three ways of finding a surrogate mom – going through a surrogacy attorney, hiring a surrogate through a licensed agency or private search. Surrogacy attorneys often work with surrogacy agencies on behalf of the gay or lesbian couple. The attorney will collect information from the couple in regards to desired personal traits, religious requirements and/or physical traits. Other details including source of semen to be used, legal and financial issues will need to be addressed before the search can begin.
Fees Associated with a Surrogate Mom
There is a long list of potential fees and financial obligations associated with surrogacy. These fees can include legal fees, medical fees and adoption fees. Typically, room, board and a salary of some sort is also provided for the surrogate mother. Some gay and lesbian couples will agree to allow the surrogate mom to live her life away from the couple during gestation while others wish to have a more personal relationship with the surrogate including attending obstetric appointments and ultrasounds.
The costs of hiring a surrogate mom can be extraordinary. If there are medical issues along the way, the gay or lesbian couple will need front the cost of these out of pocket as most insurance couples do not cover medical bills associated with surrogate parenting.

domain: law


text:
Speed up GM crops in UK, say scientists: They dismiss opponents' arguments as a 'neurosis'
- Sir Mark Walport said the country's GM regulations are 'not fit for purpose'
- He insisted EU rules banning the commercial cultivation of GM crops had to be changed to feed the world
- Critics immediately accused the Chief Scientific Adviser of 'playing a dangerous game' with the nation's safety
Rules on GM crops should be overhauled to speed up the development of the technology, Britain’s chief scientist said yesterday.
Sir Mark Walport claimed that the regulations, which have so far kept commercial GM cultivation out of Britain, are not fit for purpose and need urgent changes.
His backing for the hugely controversial technology came as a report by his committee of scientific advisers risked accusations of arrogance by saying GM opponents had a ‘neurosis’ which ‘boggles the mind’.
Rules on GM crops should be overhauled to speed up the development of the technology, Britain¿s chief scientist Sir Mark Walport has said, as he claimed that the regulations 'are not fit for purpose and need urgent changes'
Sir Mark insisted that EU rules banning the commercial cultivation of GM crops had to be changed to feed the world.
Critics immediately accused the Chief Scientific Adviser of ‘playing a dangerous game’ with the nation’s safety.
There are concerns that tampering with genes in crops to create ‘Frankenstein foods’ – strains which are more resistant to diseases, pests or produce higher yields – could unintentionally damage natural ecosystems or even affect human health.
Dr Helen Wallace, director of GeneWatch UK, said: ‘Government advisers are playing a dangerous game with farming and our food. Tougher, not weaker, regulation is essential.’
And Liz O’Neill, of GM Freeze, said: ‘Just because we can do clever things with genetics it doesn’t mean that we should, and it certainly doesn’t mean we should cut corners when it comes to safety.’
One of the authors of yesterday’s report by the Council For Science And Technology, which advises the Government, argued that the debate had been skewed by an anti-GM ‘neurosis’ which has slowed progress.
Sir Mark Walport insisted that EU rules banning the commercial cultivation of GM crops had to be changed to feed the world
Genetic scientist Jonathan Jones, who recently developed a blight-resistant potato, said: ‘How anyone could think this is a bad thing boggles the mind. We need to better explain that there is nothing intrinsically wrong with the GM method.’
Professor Jones likened current regulation to early cars having to go slowly behind people waving a red flag. He said. ‘The regulation of the technology is not proportionate. It is time to remove the red flags.’ The report, which was produced at the request of the Prime Minister, recommends sweeping reform to the EU’s regulatory system, with crops licensed in this country in the same way as medical drugs.
Sir Mark insisted that he did not want to reduce regulation but instead make it ‘fit for purpose’.
He said: ‘We take it for granted that because shelves in supermarkets are heaving with food there is no problem. But we have limited agricultural land around the world and in the UK.
‘Climate disruption and population growth are increasing the pressures on food supply. The challenge is to get more from existing land in a sustainable way, or people will go unfed.’
In a letter to David Cameron, he said: ‘We should have confidence in the scientific evidence which concludes that, when properly controlled, GM products are as safe as their conventional counterparts.
‘The longer the EU continues to oppose GM, while the rest of the world adopt it, the greater the risk that EU agriculture will become uncompetitive, especially as more GM crops are commercialised successfully elsewhere.’
All food containing GM ingredients, such as flour or oils, have to be labelled, but meat, milk and eggs from animals fed on GM products do not. Last year a Food Standards Agency study revealed 67 per cent of shoppers want all GM products labelled.
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Learning is essential to improvements in our daily lives, especially when someone says or does something that you feel is a concern. Instead of blaming the individuals, conditions, or other factors. You should acknowledge your emotions and feelings, and realize you have a choice in how you respond. Your response should be in direct connection to your identity and culture. Sometimes I get sad or angry, but it cannot guide my reaction to someone or a situation. I have to be intentional about my response. Sometimes I let my emotions and feelings guide my response and I have to remind myself to acknowledge my emotions or feelings, but I cannot let them control me. I must set my conditions to learn from the experience or interaction. The times that I respond according to my identity and culture, I can reflect on my values and beliefs. Has anything adjusted in my values and beliefs? Do I have a better understanding about the situation, individual, or encounter? Emotions and feelings are valid and we should honor them, but we do not have to be led by our emotions and feelings. The times when I do not respond according to my identity and culture, I need to consider where the misalignment concerning the situation, individual, or encounter may be. Both reflections have similar goals for me to become a better human being. As we continue to self-reflect, the questions may evolve. There is no script to this. We have to acknowledge who we are and work towards becoming and evolving into the best version of ourselves, this really causing us to reflect on what is in my sphere of influence.
Recently, I went to the gym and saw a trainer working with another individual. I love affirmations! The affirmation on her shirt said something about you being your own excuse. On the surface this seems harsh, but what I took from the phrase is I have control over my circumstances and I should not make excuses or allow distractions to cause me to lose focus. This means I have to regroup, recharge, revise plans, goals, and practices; however, I cannot become stagnant or complacent. As you process your response and reflection, take the time to visualize the various options you can take in the situation or encounter. If I demonstrate my anger, what does that look like? Who and what is affected? Will this get me closer to my goal or further away from my goal? If I demonstrate gentleness what does that look like? Should I consider a combination of the two? Can I be gentle as I express my anger in a respectful way? My intention is not to incite fear or adversarial feelings. It is to honor my emotions and feelings, but not let them impact my life. When I visualize it becomes tangible. When I have a vision for something, I have direction. I have a pathway to my greatness. Stay tuned for part 2 of this series. #salute2learning
Call to Action
Take some time to reflect on your thoughts about the concept of learning. What are your thoughts and reflections about learning? How have you embraced this idea of learning in every experience and interaction? Post your reflective thoughts. What are you thinking about the content in this post? Please share in the comment section below or use Twitter to share thoughts. Use the hashtag #salute2learning when you post on Twitter. Bring your reflective questions and let’s dialogue on Saturday, October 30th from 9 a.m. to 10 a.m. Register Here

domain: psychology


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Water. Everybody needs it to survive. We even found it on Mars. Water covers roughly 71 percent of the earth’s surface, but the amount of potable water that is safe for human consumption is at risk due to water shortages and poor water quality around the world. As a result, water scarcity affects over one billion people worldwide. For various reasons such as water overuse, pollution, drought, war, or distance, people cannot get the water they need. It affects places on every continent from developing countries to the United States, including Flint, Michigan, which has had lead-contaminated water, and even the Atlanta metro area has recently entered a severe drought. With the problem in our backyard, the Living Building Challenge urges us to respect water as a precious resource and redefines how we treat our water sources.
Submitted by Amanda Schaefer on July 20, 2016 - 12:27pm
Place is the first of seven Petals, or categories, that comprise the Living Building Challenge, and rightly so. All of the elements required for a self-sustaining building are dependent on its location. The climate, region, and natural topography of the project site must be taken into careful consideration because the built environment should seamlessly coexist with its natural surroundings. A living building must be well adapted for its environment so that it can generate energy, capture and treat water, and grow food in the most efficient way.
Submitted by Amanda Schaefer on July 14, 2016 - 10:58am
Meatless Monday is a sustainability movement that helps the environment and the health of it’s participants. Going meatless once a week may reduce your risk of chronic preventable conditions like cancer, cardiovascular disease, diabetes, and obesity. It can also help reduce our carbon footprint and save precious resources like fossil fuels and fresh water. I have decided to participate in Meatless Monday for a month and document my experiences.
Breakfast was easy. A piece of fruit and a toaster waffle and I’m out the door. Lunch was harder. Having class during the day, I typically grab lunch at the student center. I found myself quickly realizing that there are less vegetarian and meatless options than I originally expected. Chic-fil-a basically serves chicken sandwiches only, so that was out. Maybe I could have found a bean only options at Taco Bell but I wasn’t interested. Subway seems healthy, but I always order turkey sandwiches so what could I order there? I remember seeing their veggie patties there and decided against it.
For the next week I am going to make a few small changes in my lifestyle to try and reduce unnecessary energy usage. One source of waste is merely leaving on lights and electronics that I am not using. Another source is phantom energy. This term refers to energy used by electronics and appliances that draw energy from a power outlet even when they are turned off. Some of the biggest uses of phantom energy are TV’s, electronics chargers, and game consoles. The best way to prevent yourself from using phantom energy is to unplug these things when they are not being used.


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Voice samples recorded in studio: Female
- Pack created on: Nov. 11, 2012, 1:08 a.m.
- Number of sounds: 8
- Number of downloads: 72
Recorded in studio: Neumann TLM103, Focustrite Quad Mic-Pre, Protools. Effects Used: Pitch shift, Multi band compresser, compresser, Waves' GTR Amp ...
VO outtake from a recording session. Elf is complaining about Christmas Eve not going as well as could be expected. ...
Raw Vox used for the "Bass Hell Monster" sound from AudioRichter uploaded to FreeSound.org
Out take from a VO recording session. Talent kept stumbling over the script. I thought it was hysterical and kept ...
Female voice recorded in studio saying "Ahh" with various inflections happy, peaceful, pleasant
Mmm female voice recorded with various inflections.
Female voice recorded "ahh". Different styles: surprised, scared, startled, excited...
Various female "oooh" - Playful, sexy, excited, flirty, airy, longing, dreaming... Recorded in studio.

domain: entertainment


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The Pendulum Clock Mechanical Gear is an extremely well designed good machining model set. The interlocking mechanisms are pretty intuitive and not overly tight. Assembling without glue and chemicals on details that are already cut and ready to assemble. This is a perfect mechanical toy for anyone who appreciates the beauty of gravity and gears.
- Finished Product Dimension: : 234 x 117 x 346 mm
- Box Dimension: 240 x 330 x 40 mm
- Materials: Wood
- Wood Pieces: 166pcs
- Time to Complete: ~5 hours.
Recommended Age: 14 and up

domain: hobby


The Evactron® EP de-contaminator is the latest remote RF plasma cleaning system from XEI Scientific as part of XEI Scientific’s E-series.
The Evactron® EP model is meant primarily for users involved in the fields of physics and materials science who design and use customized vacuum systems. This model is similar to the Evactron® ES model, and offers users maximum cleaning rates at low pressures.
The instrument uses flowing afterglow cleaning with air to clean carbon compounds from vacuum chambers which operate with turbo molecular pumps.
The Evactron® EP has manual control with LED status lighters and a front plasma cleaning switch. It is programmed with fixed operating conditions, times and powers.
The main features of the Evactron® EP de-contaminator are listed below:
- High reliability 20W RF 13.56 MHz power supply
- Energy-efficient hollow cathode plasma
- Flow through gas supply
- Ideal cleaning conditions are preset
- Low pressure operation @1-3 Pa for long lived radicals and rapid cleaning rates
- Plasma radical source design maximizes delivery of radicals to chamber
- Vacuum only operation interlock
- Fixed match offers highest plasma power transfer
- “Pop” ignition of the plasma functions at all pressures below 100 Pa or 750 mTorr
- Can start and operate at turbo molecular pump compatible pressures
- Vacuum gauge is not needed
- Front panel adjustments is not required, on/off switch only
- NW 40 flange standard, CF 2.75 optional


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The Los Angeles Times reported a story over the weekend on how Brazil is trying to combat sex tourism ahead of this year’s World Cup:
Brazilians complain that stereotypical images lead to prejudice and unwanted advances when they cialis tablets are traveling abroad.
‘First, they say that I don’t “look Brazilian,” because I don’t have big breasts or a big’ rear end, says Alexa Santoro, a 23-year old student from Sao Paulo who is training to be buy levitra canada a funeral makeup artist. ‘Then, the abuse starts. They think that I’ll just jump into bed with them, since that’s how they think things work in Brazil…. It can really make you feel bad.’
Santoro says she was not encouraged by reports that prostitutes around the country were taking English lessons before the World Cup.
The girl from Ipanema isn’t for sale anymore.


BILOXI, Miss. (AP) — A Tennessee man who authorities say fled from a traffic stop and led police on a chase has been arrested in Mississippi.
Biloxi police Lt. Christopher De Back says an officer tried to pull over 26-year-old Cody Blasingame on Monday morning for a traffic violation. He says Blasingame took off as the officer approached the vehicle. News outlets report the vehicle Blasingame was driving was reported stolen.
Authorities say Blasingame stopped to let two passengers out the vehicle and continued the chase until he struck another vehicle.
Blasingame ditched the vehicle and ran a short distance before he was arrested. The female passenger and the person in the other vehicle were taken to the hospital.
Blasingame was arrested on several offenses including possession of stolen property and eluding. It’s unclear if Blasingame has a lawyer.


Nickel Welding Alloy AMS 5786
Technical Data Sheet
|Chemical Composition Limits|
|AMS 5786||Bal||23.0-26.0||4-6||4-7||0.12 max||1.0 max||0.03 max||0.04 max||2.50 max||0.60 max|
AMS 5786 is used to join dissimilar metal combinations including A286 (AMS 6532), L-605(AMS 5796). It is used for combustor repair and manufacture for welding turbine blades to rotor hubs. shroud rings, etc.
|Cross-Reference of Specifications||MSRR 9500/213
Alloy Hastelloy W
62.5Ni 5.0Cr 24.5Mo 5.5Fe
(Commercial Grade AWS A5.14 ER Ni Mo-3).
|Availability||Ex stock MIG spools and TIG rods
For all stock availability contact Sales.
Tensile strength: 127ksi, Density 9.03 gm/cc
Return to Main Welding Page
At Aircraft Materials all stock items can be shipped out within 24 hours, usually within the same day. Even cutting orders for bar or sheet can be processed and dispatched the same day, and for time-critical situations such as AOGs, we have a dedicated AOG service desk ready to help (firstname.lastname@example.org).
Thanks to our global logistics network we can source from anywhere in the world in just a few days. We use a range of transport partners to enable us to ship overnight within the U.K. and Europe and provide fast shipping solutions to the rest of the world. If your requirement is urgent we can offer a priority shipping service, but also if time is not so critical we can offer more cost-effective options to ensure you get the best value for money. To find out more about our services click here.
Every effort is made to ensure that technical specifications are accurate. However, technical specifications included herein should be used as a guideline only. All specifications are subject to change without notice.
Sell your Stock Online at 4metal.co.uk


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Small Animal ; Treats, Food & Bedding ;.
Naturals Soft & Safe Bedding . Naturals Play ‘n’ Bedding Pods 2pcs . Product code: 19494. Natural Kapok seed pods full of soft ‘n’ safe bedding fibre Ideal boredom breaker for hamsters, mice and gerbils Pets can gnaw on the pods, take out the natural bedding and even snack on the edible seeds Bedding.
Chipsi Wood Shavings – 350l CHIPSI EXTRA. The complete wood product for exotic pets and birds! Hygienic Dry Dust-free Various grain sizes » CHIPSI EXTRA. CHIPSI EXTRA SOFT. The perfect ALTERNATIVE to sand or wood shavings! First class for dry terrariums and bird aviaries. £9.99 Chipsi Wood Shavings – 350L. Add to Basket. 10+ In stock. Details. Keep your small
Rosewood Naturals Play ‘n’ Bedding Pods 2 Pack. Product Code: 7107865P. Rosewood Naturals Play ‘n’ Bedding Pods 2 Pack.
Kapok pods are sustainably and ecologically harvested.
In some cases it may be necessary to crack the pod open first with your fingers to give your small animal easier access to the bedding and edible seeds. Fun for all.
Home › Small Pets › Hamster › Hamster Litter Bedding › Rosewood Naturals Play n Bedding Kapok Pods Small Animal.
Spoil your mouse, rat, degu, gerbil or any other small animal the luxuriously soft and 100% natural Rosewood Naturals Play n Bedding Kapok Pods – 2 Pods.
Kapok pods are not only a great and healthy all natural boredom breaker that are great for healthy teeth, but they also open to reveal soft and fluffy fibres that make for warm and luxurious small animal bedding.

domain: pet


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In his first media conference after taking over as the Chief Executive of the Chamber of Mines of South Africa, Mr Bheki Sibiya reiterated the Chamber of Mines' commitment to the improvement of safety in South Africa's mines.
Noting that figures for 2010 released by the Department of Mineral Resources indicated a 24% improvement on the recorded 2009 fatalities in the mining industry, Mr Sibiya expressed sadness that 128 mineworkers lost their lives last year. "Our vision is that every mine worker should go home unharmed every day and we are therefore deeply saddened by the death of so many of our colleagues.
"The 24% improvement makes 2010 the best safety year in South Africa's mining history. We are grateful for the co-operation we have received from the Department of Mineral Resources, the leadership of organised labour and fellow mine workers in addressing issues of health and safety in South Africa's mines. We also recognise the hard work of Chamber members, each of which have their own programmes to improve health and safety. Without the involvement and co-operation of all these stakeholders, it would have been impossible to have achieved these results. We hope that in working together with government and unions to accelerate the implementation of the 2008 Tripartite Action Plan on Health and Safety, more progress will be made in the year ahead. The Chamber of Mines and its members are committed to this".
The media conference was held to brief members of the media on the mining industry's safety initiatives of 2010 and plans for further improvements in 2011. These include initiatives such as the Learning Hub - which the Chamber established in 2009 to encourage mining companies to actively learn from the pockets of excellence in the industry - and other initiatives such as the culture transformation framework intended to entrench a more participative and caring culture within the mining industry.
To download the Mine Safety presentation, click here.


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Harriet Tubman is a larger than life icon and an American hero. Harriet was born into a family of eleven children who were born into slavery. Benjamin Ross and Harriet Greene were her parents, and lived on a plantation in Dorchester County, Maryland. Harriet was put to work by the age of five, and served as a maid and children’s nurse. At the age of six Araminta was taken from her parents to live with James Cook, whose wife was a weaver, to learn the skills of weaving. James Cook would order her to guard his muskrat traps, which compelled her to walk through the water. At the age of 12 she became a field hand. Because Harriet Tubman wanted freedom, she fought constantly to achieve it. Harriet went from slave to inspiration in a matter of years.
Slaves, one of the biggest economic resources for the US in the 17 and 1800s. Harriet Tubman was one of many slaves who escaped after her master died in 1849, but rather than fleeing the South, she stayed to help save hundreds of slaves. Harriet did many great things in her lifetime such as saving over 38 slaves on the underground railroad, saving 800 slaves as a union spy, as well as she served as a civil war nurse and caregiver . Harriet Tubman’s greatest achievement was her time as a caregiver.
The difficulties and hardships of slaves in slavery in the American South explores the lives of slaves and what they went through. Slaves had rough education and faced physical pain every day. For example a couple of slaves are Harriet Tubman and Frederick Douglass.
The Underground Railroad was a network of secret routes and safe houses used by 19th-century enslaved people of African descent in the United States. It was in efforts to escape to the Free states and Canada with the aid of abolitionists that showed sympathy towards them. The Underground Railroad was not “underground” and it wasn’t actually a “railroad.” The reason it was called “underground” was because of how secretive it had to be and it was called a “railroad” because it was an evolving form of transportation. The Underground Railroad had many conductors; which is an individual who escorted or guided freedom seekers between the stations or the safe houses. The most famous of them all was Harriet Tubman.
The Civil War was a horrid event that greatly affected our modern day lives. From 1861 to 1865 the Union and the Confederates fought to protect what they thought was right. Throughout the war many people turned up and encouraged change in areas they believed were lacking thought such as, abolition, women 's rights, and suffrage. One of this people was Harriet Tubman. Harriet Tubman was an abolitionist, which means that she was against slavery. She helped develop the underground railroad, which helped many slaves escape to freedom.
Both Harriet Tubman and the Underground Railroad played a huge role in causing the Civil War. They both helped slaves escape the torture that they had to face every day, and were able to give them the lives that they deserved. Many enslaved people’s lives were changed due to the generosity and courage of Harriet Tubman and anyone else who worked on the Underground Railroad. These people risked their freedom everyday helping these slaves whom they did not even know, all because they knew that what they had to face was inhumane. The world was forever changed by the efforts that Harriet Tubman and everyone else put into the Underground Railroad, and we will always recognize the sacrifice that they had to make.
Abolitionist and humanitarian Harriet Tubman recounted her experience with freedom from slavery. Harriet Tubman is one of the many leaders of civil disobedience. Civil disobedience is the violation of an unjust law and the acceptance of the consequences given to the protestor (Erika). In America, civil disobedience has played a noteworthy role in many social reforms that many take for granted today. Civil disobedience is not followed by everyone. We all have the choice to do what we feel is right.
Harriet Tubman is one of the United States most successful abolitionist during the American Civil War, she was a spy for the Union and the conductor of the Underground Railroad, she remains a great inspiration and is a true American hero. Tubman planned the successful Raid at Combahee Ferry in which she freed over 750 slaves it was the first military operation that was led by an American women. Tubman is mostly know for being the conductor of the Underground Railroad, she went on a totally of 19 trips and never lost a single passenger. Harriet Tubman's popularity has reached folkloric status and her story has been retold in over 40 children's books. What is so extraordinary about Tubman is that she was an ex female slave who remain illiterate
The Significance of Harriet Tubman and Harriet Beecher Stowe’s involvement in the Underground Railroad (as part of the Abolitionist Movement, 1850-1860)
“Four score and seven years ago our fathers brought forth on this continent, a new nation, conceived in Liberty, and dedicated to the proposition that all men are created equal.” -Abraham Lincoln. As this quote says, our ancestors’ intention for this land was that all humans would be treated the same way; equal. But this world didn’t end up like they wanted. There is discrimination; women and different races aren’t treated equally. Activists Elizabeth Cady Stanton, Susan Sparrow, and Harriet Tubman, along with many others, take this problem to solve from different “sides.” Stanton working mainly for women rights, Sparrow working for equal payment, and Tubman working mainly for slavery abolishment. All of these activists wanted all men and
Throughout history people have been working towards African American rights. There have been countless individuals, as well as entire organizations, who have made significant advancements in this movement. Though the struggle for rights has been a long process, these people’s contributions eventually led to emancipation and further rights of African Americans.
When we talk about slavery, many historical names come to mind, the biggest being President Lincoln. Although Lincoln was against slavery, it proved to be a long road ahead before his emancipation proclamation was issued. Lincoln was not the first to confront issues of slavery in the United States. It took a seamlessly long time before words were spoken that could even begin to abolish slavery slowly. Blood was soon shed to stop this inhumane way of life, but at what cost? What was the impact on The United States and to those who had to live this life on a daily basis?
The book, “Harriet Tubman: The Road to Freedom” was written by Catherine Clinton. Catherine Clinton is the Professor of American History at University of Texas San Antonio. She is extremely qualified due to her intensive work dealing with this time period of American History. She studied sociology and American History at Harvard and then received her Ph.D. at Princeton University. She has written numerous books about American History, and more specifically, slavery and black history in the United States. Due to these reasons, she is highly qualified to write such a book.
The Underground Railroad offered a passage to freedom as well as hope for many enslaved people. It was developed in the early 1800s, however, it was primarily used during 1850 through the 1860s. It was an operation that succeeded because of people who held the belief that all people are entitled to equal rights regardless of race. It was a secret system which was developed to help slaves escape to freedom. Escaped slave, Harriet Tubman, was instrumental in assisting numerous slaves travel through the Underground Railroad beginning in 1850. This passage helped slaves escape from the South into the North and extending as far as Canada. The Underground Railroad was a complex system that proved to be successful for thousands of slaves who wanted to gain freedom and equality.

domain: history


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Updated June 17
The Iowa Economic Development Authority unanimously approved Sub-Zero Group Inc.’s financial incentive package June 17, clearing the way for the kitchen appliance company to construct a $140.6 million manufacturing facility in southwest Cedar Rapids.
“So many people are involved in an effort like this,” said Doug Neumann, executive director at the Cedar Rapids Metro Economic Alliance, in a statement. “It demonstrates again the importance of constantly pursuing business attraction and business expansion projects to keep our economy marching forward.”
Updated June 14
At its regular meeting June 14, the Cedar Rapids City Council approved a resolution for a project term sheet and sponsorship of a financial assistance application for a new Sub-Zero light manufacturing facility in southwest Cedar Rapids that would bring nearly 200 new jobs to the Corridor.
Sub-Zero, headquartered in Madison, Wisconsin, is proposing a $140.6 million, 400,000-square-foot manufacturing facility at 10015 Sixth St. SW, just south of 7G Distributing and about a mile east of the Eastern Iowa Airport, according to city council documents.
The project investment would include $90 million in real property and improvements and $50.6 million in machinery and equipment. Construction would begin in August 2023 and is projected to be completed by August 2025.
The project would create positions for 192 new full-time employees, 127 of which would be paid at or above the state’s current high-quality wage rate of $24.20 per hour. The state requires those jobs to be filled by December 2026.
Sub-Zero manufactures refrigerators and other appliances for home and commercial use under the Sub-Zero, Wolf and Cove brands.
The council was asked at its June 14 meeting to authorize a project term sheet with terms and conditions to be included in a development agreement with Sub-Zero and a local entity headed by developer Tiffany Earl Williams. Under the agreement, the city would also sponsor an application for state financial assistance for the program through the state’s High-Quality Jobs program.
“We have reached the point that our three main sites are burgeoning and full, so we are seeking a new location to add to our footprint for the next leg of our journey,” said Scott Wareing, senior vice president of operations and product design for Sub-Zero, during public comment. “It’s just a phenomenal fit for us and you.”
The project will qualify for a 20-year, 75% tax exemption, as well as local tax abatements subject to maintaining minimum employment thresholds.
The council will consider a full development agreement for the project at a future meeting, likely to take place in August. The IEDA Board will consider the project’s state incentives June 17.
Ron Corbett, vice president of economic development for the Cedar Rapids Metro Economic Alliance, said a site selection consultant working for Sub-Zero reached out to state economic development officials in the fourth quarter of 2021 with a Request for Information (RFI) on possible development sites in Iowa.
In response, Cedar Rapids officials submitted several sites in Cedar Rapids for consideration, Mr. Corbett said.
“There were several visits by the company and the consultant group over the last six months, where we had a chance to sell the assets of our community,” he said. “Thankfully, they chose Cedar Rapids, and we’re happy to celebrate this great success.”
Bringing Sub-Zero to Cedar Rapids was described as a “collaborative effort” between the Iowa Economic Development Authority, Cedar Rapids Metro Economic Alliance, Alliant Energy and Kirkwood Community College, said City of Cedar Rapids Economic Development Manager Caleb Mason during the meeting.
Several factors weighed into Sub-Zero’s decision to locate in Cedar Rapids, Mr. Corbett noted including the city’s strong manufacturing base, the ancillary support of well-trained operations workers, and the vocational and technical education programs offered through Kirkwood Community College.
“Proximity to their home office (in Madison) was another check mark in our favor,” he said.
Significant announcements like this shouldn’t be taken for granted, Mr. Corbett said.
“It’s always a good thing when you diversify your economy,” Mr. Corbett said. “We’ve had a lot of successes, but we’ve also had some setbacks, when you think of Toyota Financial closing their offices and NextEra shutting down the (Duane Arnold) nuclear facility. Not every economy is always creating jobs. You’re losing some as well, so creating more jobs and diversifying the economy is a great thing.”
Southwest Cedar Rapids has seen a number of major development projects in recent years including three $100 million-plus projects in three consecutive years – the $170 million BAE Systems aerospace manufacturing facility along Interstate 380, first announced in 2020; the $108.6 million FedEx distribution facility near the Eastern Iowa Airport, announced in 2021; and this year’s Sub-Zero project. The BAE and FedEx projects are set for completion later this year.


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Lyxor has announced a new range of ETFs with what it claims are the lowest fees available in Europe in a move which emulates the fee compression taking place in the US market.
Two of the new Lyxor Core range of ETFs come with fees set at just 4 basis points (0.04%) which the company claims is three basis points lower than its nearest competitor.
The 0.04% level is also one basis point lower than the current lowest offering on the market, which according to ETF Stream research in September was the HSBC Euro Stoxx 50 UCITS ETF which has a total expense ratio (TER) of 0.05%.
The two new funds are the Lyxor Core Morningstar UK ETF and the Lyxor Core Morningstar US ETF.
The range extends to 16 funds covering the major equity markets as well as fixed income gilts and TIPS. Four new funds have been created while 12 existing funds have had their fees cut. The four new funds will be launched on the London Stock Exchange tomorrow, 22 March.
Intriguingly, Lyxor says that to aid simplicity and transparency none of the funds will undertake any securities lending.
Arnaud Llinas, head of ETFs and Indexing at Lyxor, said: "Investors tell us they want simple, high quality ETFs at low costs. We've launched our Core range to achieve precisely that - cornerstone investments for any portfolio. Lyxor's mission is to provide quality, innovative investments - our core range is a perfect complement."
Lyxor said the focus on low fees has come both from the top with regulators expressing a desire for consumers to be offered a cheaper product as well as from the end user themselves who is searching for better value from their investments.
Indicating where the drive for lower fees would have the most impact, Lyxor said the new core range had generated significant initial interest from a range of investors and third-party providers, such as Nutmeg.
James McManus, investment manager at Nutmeg, said: "This type of product innovation is exactly what the ETF industry needs: offering investors a lower cost option without compromising on quality. Lowering costs means investors keep more of their returns and Lyxor are leading the way."


Constant temperature and humidity test box features:
◆ Adopt imported high-precision microcomputer color touch screen temperature and humidity controller, switch between Chinese and English,
◆ Test hole (left side of the machine) 50mm, which can be used for external test power line or signal line. ◆ Original and fully imported low-noise high temperature and low temperature compressors imported from Europe and the United States. Strip to ensure airtightness ◆ The inner and outer box is made of imported (SUS # 304) stainless steel plate.
◆ The observation window is made of multi-layer hollow tempered glass, and the inside is laminated with a sheet-type conductive film (the test process can be clearly observed)
◆ Safety protection device. When any fault occurs, the fault status is displayed on the screen and the power is cut off to ensure the safety of the machine, the tested product and use.
1. 1500L ，各种容量可以满足不同用户需求。 The inner cavity capacity can reach 1500L , and various capacities can meet the needs of different users.
2. The inner cavity is stainless steel to prevent corrosion, and the humidity barrel is electrolytic polished.
3． The front of the bucket allows easy access to the system.
4． Water can also be supplied during operation.
5． Direct water system is convenient for users to operate for a long time (optional)
6. Easy to observe samples.
7. Tempered glass with built-in heating wire.
8. 灯寿命长，也节能。 LED lights have a long life and are also energy efficient.
9. Large observation windows and internal glass doors make it easy to observe the sample status (optional).
． 10 . The cable port can be connected to external controllers and wires.
． 11 . 50mm 的电缆口。 A 50mm diameter cable port is standard on the left side of the device .
． 12 . 50mm 或者 80mm 的电缆口可以定制。 Additional 50mm or 80mm cable ports can be customized.


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Combined High Voltage and lcing Tunnel Tests on Radomes
ISSN: 0148-7191, e-ISSN: 2688-3627
Published June 22, 1999 by SAE International in United States
Annotation ability available
Lightning and static charging tests were performed on one transport aircraft radome and one small aircraft nose radome at the NASA Icing Research Tunnel (IRT), Lewis Research Center, Cleveland, Ohio. The primary purpose of these tests was to evaluate the effects of rain and icing conditions on the lightning protection effectiveness of segmented-type diverters. A secondary purpose was to evaluate the effects of static electrical charges deposited by rain and ice particles. The tests were performed under Task 2.4 of the Joint Program on Improving Lightning and Static Protection of Radomes. Fifty-four lightning tests were performed on two radomes to evaluate the effect of icing, precipitation drop size, and temperature on the ability of segmented diverters to prevent puncture of a radome skin and attachment to the internal radar antenna. Five of the tests resulted in radome puncture under icing conditions. One of the punctures occurred under rain without radome icing. At the time this puncture occurred, twenty previous tests had been performed on the same radome with the high voltage electrode at the same position. As a result, the radome test section had been repeatedly stressed which probably resulted in the puncture.
Ice buildup, determined from measurement and observation, ranged from approximately 3 mm (.125 in.) to 25 mm (1 in.) on the large transport radome. The 25 mm (1 in.) ice buildup allowed two punctures to occur between diverters at their tip ends during a single test. The thinner, clear ice, allowed single punctures to occur during each of three tests on this radome.
A single puncture occurred on the small aircraft radome when rime ice buildup allowed a puncture to occur at the antenna edge even though the adjacent diverter appeared to ionize.
Measurements of static charge voltage and current yielded insignificant readings. Additional tests performed at the NASA IRT at a later date using a 305 mm × 305 mm (12 in. by 12 in.) plate showed that no appreciable charging occurred at wind velocities of 161 km/hr (100 mph), the approximate velocity in the diffuser section where the radomes had been located. Negligible charging occurred when the plate was in the 90 degree orientation (plate parallel to windstream) and also when the precipitation drop size was 14 μm. The highest charging current (1.15 μA) occurred at a velocity of 483 km/hr (300 mph) at −4 C (25 F), 40 μm drop size, and plate orientation of 0 degrees.
CitationPlumer, J., Ulmann, A., and Hardwick, J., "Combined High Voltage and lcing Tunnel Tests on Radomes," SAE Technical Paper 1999-01-2389, 1999, https://doi.org/10.4271/1999-01-2389.
- Plumer, J. A. Lightning Strike Attachment Tests of Radomes Under Simulated Rain and Icing Conditions at NASA Icing Research Tunnel Lightning Technologies, Inc. Report LT-TP-95-121 28 September 1995
- Plumer, J. A. Pryzby, J. E. Lightning Strike and P- Static Tests on Radomes Protected with Segmented Diverters Under Precipitation and Icing Conditions Lightning Technologies, Inc. Report 29 February 1996


Despite the end of the Cold War and the arms reductions that followed, there are roughly 15,000 nuclear weapons across 9 states and materials to make many more spread around the world. Many countries use nuclear technologies for energy, medical applications, and even to enhance food security – extending the dangers beyond the weapons-possessing states.
This course provides reports, events, and multimedia tools produced by the CSIS Proliferation Prevention Program that seek to examine some of the major nuclear risks of the 21st century - beyond just the nuclear weapons themselves- and ways these risks could be mitigated. Major topics include the possibility of switching from Highly Enriched Uranium (HEU), a nuclear weapons-building block, to safer Low Enriched Uranium (LEU) for naval fuel; the growing stockpile of separated plutonium, also a key ingredient for nuclear weapons, in Northeast Asia; and the level of transparency some countries have offered into their nuclear stockpiles. More content will be added throughout 2017 and 2018, so subscribe to stay abreast of the latest.


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In the words of that eminent sports philosopher, John McEnroe, “You have got to be kidding me!”
ESPN has suspended Tony Kornheiser for two weeks for comments he made about Hannah Storm’s attire. Storm is a cohost of ESPN’s SportsCenter TV program.
Kornhesier, who also cohosts Pardon the Interruption (on ESPN), made the “offensive” remarks on his radio show on ESPN 980 in Washington DC late last week:
Hannah Storm in a horrifying, horrifying outfit today. She’s got on red go-go boots and a catholic school plaid skirt … way too short for somebody in her 40s or maybe early 50s by now. She’s got on her typically very, very tight shirt. She looks like she has sausage casing wrapping around her upper body … I know she’s very good, and I’m not supposed to be critical of ESPN people, so I won’t … but Hannah Storm … come on now! Stop! What are you doing? … She’s what I would call a Holden Caulfield fantasy at this point.
A very brief item on ESPN.com on the incident reads as follows:
ESPN has suspended “Pardon The Interruption” co-host Tony Kornheiser for two weeks following comments he made on his Washington-based radio show last week.
On his radio show, Kornheiser made critical comments about the wardrobe of morning “SportsCenter” co-anchor Hannah Storm.
ESPN executive vice president of content John Skipper released the following statement:
“Tony Kornheiser’s comments about Hannah Storm were entirely inappropriate. Hurtful and personal comments such as these are not acceptable and have significant consequences. Tony has been suspended from PTI for two weeks. Hannah is a respected colleague who has been an integral part of the success of our morning SportsCenter.”
Kornheiser apologized for the remarks on his radio show Friday.
At the risk of being ignorant — and I am ignorant in that I did not hear Kornheiser’s remarks myself — most of what I’m reading online and in emails makes this seem like a tempest in a teapot and the punishment certainly does not fit the “crime.” (I have seen Storm’s outfit, on the other hand. Kornheiser may have exaggerated a bit in his sartorial descriptions, but that’s like Randy on American Idol calling someone “pitchy”; it’s a matter of personal taste.)
Was what he said “hurtful and personal?” Depends on your perspective and how sensitive you choose to be. Let’s be clear here, we’re not talking about Imus, or Jimmy the Greek, or Al Campanis. There’s no racial or religious animosity here. It’s not even sexist really, since Kornheiser routinely comments on the wardrobe choices of his male colleagues as well (could be construed as age-ist? Kornheiser is 61 himself).
And — not to get him in any more trouble — but why is it all right for him to regularly ridicule the Today ‘s Hoda Kotb, but this merits a suspension? Is it because he’s talking about an ESPN “product?” Did management have an ulterior motive?
This is his shitck. He’s loud, opinionated (but never vulgar), and no one is off limits (he was suspended in 2002 for remarks made against ESPN about the firing of a coworker). And if the suits in Bristol haven’t realized this in all the years Kornheiser has been in their employ, someone hasn’t been paying attention.
More on the situation here, here, and here. Even those who don’t care for Mr. Tony’s style feel compelled to defend him. In fact, I find it amusing that so many outlets that normally wouldn’t even look over their collective eyeglasses at this story are chiming in.
Of course, this could all just be a strategic ploy to garner ESPN some attention.


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A protest against the Citizenship Amendment Bill, 2019 in Guwahati, Assam, December 11 (Photo: Getty Images)
In 2005, a 55-page article titled “Globalized Citizenship: Sovereignty, Security and Soul” authored by Professor Berta E. Hernández-Truyol was published by the University of Florida Levin College of Law. In the article, Prof. Hernández-Truyol narrated in some detail, with endorsement, the creation of limits over time on the sovereignty of states in general and in particular in relation to matters of citizenship. In the Introduction to the article, the Professor posited that “a globalized citizenship grounded on a human rights model will strengthen personhood by denationalizing states’ claims on individuals’ rights”.
To this end, she argued that “for the human rights model to be of utility to the globalized citizen project, it must be reconstituted with an anti-subordination agenda.” She asserted that the project “must include the voices of the marginalized-both persons outside Western cultures and subordinated persons within Western cultures-all women; racial, ethnic, religious, cultural and sexual minorities; the poor; and the differently-abled.” The stated object of this project was, of course, “a new vision of human rights” which “refocuses the discourse and creates a globalized citizenship movement from below that embraces and empowers those currently in the periphery.”
To achieve the said goal, the Professor proposed moving “toward a new conceptualization of limits on sovereignty: a proposed globalized citizenship model that draws from traditional citizenship theory, uses the human rights structure as its foundation and places limits on the power of entities, including states and transnational and multinational organizations, associations or groups, to act if the consequence is a violation of human rights norms.” According to her, what separated her conceptualization from the previous conceptualizations of the limits of sovereignty was that its “affirmation emanates from the individual him/ herself (and others similarly situated around the globe) who has suffered as a consequence of a breach of norms regardless of whether the norm violator is a state actor.”
Would it be a stretch to draw parallels between the position and language of Prof. Hernández-Truyol, and the “arguments”, tone and language employed by a significant cross-section of critics and opponents of the CAA, the NPR and the NRC (let’s call it “the CNN”)? Perhaps not. If anything, it could be argued that the critics and opponents of the CNN have drawn heavily from or are inspired by the script elaborated by Prof. Hernández-Truyol in her article. This could also indicate a handshake, albeit inconclusive and perhaps inadvertent, between global advocates of global citizenship and its sympathizers in India. However, experience shows that rarely are such handshakes coincidental, and usually the script of the relevant stakeholders in India on such issues follows the global template (which is distinctly Left of Centre) with necessary customizations to suit Indian tastes and issues.
This is perhaps why it would be naïve to assume that everyone who opposes the CNN is necessarily doing so to defend Constitutional values. While some may genuinely, however erroneously, feel that the CAA violates Article 14 of the Constitution; it may not be unreasonable to assume that their misplaced sense of Constitutional righteousness and sanctimony are, in fact, being pressed into service by and at the behest of those who wish to further the cause of globalized citizenship. The all-important and fair question that then arises is whose cause is being advanced by the proponents of the globalized citizenship? Everyone who believes in the continued relevance and indispensability of sovereign states, albeit in a multipolar and interconnected world order, has the right and duty to ask this question. This is because such movements have displayed a marked tendency to interfere with the internal affairs of sovereign states, using human rights as a politically correct conduit and it is never clear if the voices which represent such movements are independent free actors or not-so-independent non-state agents.
If the claims of Global Citizenship (GC) as a movement were to be accepted on face value and it is assumed that its goals are truly what it claims to be, even then it is a Loki-esque recipe for chaos because it expects sovereign states, be they nation states like European countries or civilization states like India or China, to sacrifice the lifeblood of nationhood, namely citizenship, at the altar of this Utopian and quixotic pipedream. The primary premise and modus of GC appears to be to paint the very idea of sovereign states as fundamentally Orwellian which stands in the way of the genuine needs, aspirations and human rights of marginalized groups and displaced communities. Consequently, to expedite the process of the withering away of sovereign states, what is proposed by Prof. Hernández-Truyol as the alternative, is further abridgement of the sovereignty of states through the use of a modified human rights framework. Under this framework, the validity of the actions of a sovereign state is examined solely through the prism of a non-citizen who believes that she or he is entitled to the citizenship of the state becauses he or he is an alleged victim of breach of human rights norms by third parties who may or may not be state actors.
While this proposed victim-driven framework is riddled with grave dialectical loopholes the size of black holes and merits a detailed dissection to expose its flaws, fallacies and dangers, its manifest impracticality becomes evident when it is applied in the context of the CAA. Admittedly, members of the six persecuted religious minority communities from Pakistan, Bangladesh and Afghanistan who are the beneficiaries of the CAA 2019 are bound to benefit from such a framework. However, it is equally evident and even obvious that the framework is capable of being exploited by anyone, regardless of whether they are victims since the framework neither proposes effective safeguards to verify claims of victimhood nor offers conceptual or definitional clarity as to what qualifies as victimhood. In fact, the framework would play into the hands of someone who seeks citizenship of a state only because that state has better economic opportunities to offer. What is even worse is that such a framework could conceivably aid inimical foreign interests by providing them with a human rights alibi to not just legally enter the state they wish to undermine, but also become its citizens and subsequently foment and fuel “local” and “indigenous” demands of “self-determination”.
This is precisely what makes the GC model impractical and dangerous since it is capable of being subverted by specific vested interests. A hyper-conservative skeptic might go so far as to say that the GC model has been designed to advance specific vested interests, which include foreign policy objectives of state actors and goals of powerful non-state actors, by lending it the benign and unobjectionable face of human rights of the stateless, the destitute, the marginalized and the persecuted. While one may not subscribe to such degree of cynical scepticism, it is not beyond the pale of reasonableness to contend that the GC movement could unwittingly find itself being employed by less noble and altruistic interests, which appears to be the case with CAA protests as the dust gradually settles and the facts begin to emerge. Critically, apart from state sovereignty, the very legitimacy of human rights and the reasonable expectations of persecuted and displaced groups and individuals could suffer as a consequence of them being used as cannon fodder to further subterranean agendas. Clearly, the GC movement, in whichever avatar it manifests itself in whichever territory, by whatever name it is called, is certainly not a credible alternative to the considered, calibrated and collective decision-making processes of sovereign states.
The antidote to the selfishness and intransigence of sovereign states is not to undermine their sovereignty through sophistry, but to offer feasible incentives for transparent cooperation and burden-sharing instead of threatening their very existence which could only exacerbate the intransigence. At the same time, it is imperative to take into account the legitimate reservations of sovereign states in bestowing citizenship on foreigners in a laissez-faire manner. After all, the concept of citizenship affects the very identities of nation states as well as civilization states, which should not be pejoratively dismissed as “ethnonationalism”.
It is important to appreciate that, in the interest of self-preservation; every nation has its own history which it has a right and duty to learn from. No sovereign state needs to be apologetic about this nor should it be guilt-tripped for doing so citing violation of human rights or secularism or worse, labelling them fascist. A state’s foremost duty is to protect itself and its people, and this duty permeates even its decision to grant citizenship to illegal migrants-turned-refugees or to grant refugee status to illegal migrants. History provides a state with the strongest possible Constitutional, factual and logical justification for the manner in which it chooses to exercise its discretion, particularly in sensitive matters such as grant of citizenship to foreigners. And no test of reasonableness or canon of equality under Article 14 of the Indian Constitution precludes the state from drawing from history. If anything, the Constitution as a document must be alive to history, since it is a product of history.
J Sai Deepak is an engineer-turned-lawyer practising as an arguing counsel before the Supreme Court of India and the High Court of Delhi. He is the author of India that is Bharat: Coloniality, Civilisation, Constitution


text: Upon regulated necrosis, receptor interacting protein kinase 3 (RIPK3) phosphorylates the mixed lineage kinase domain-like (MLKL) protein at Thr357 and Ser358 located in the activation loop of its pseudokinase domain. The RIPK3-mediated phosphorylation relieves the inhibitory effect of the pseudokinase domain of MLKL, thus allowing the activated MLKL to oligomerize and translocate from the cytosol to cell membranes to cause membrane disintegration. The flotillin-mediated endocytosis was found to antagonize MLKL-mediated plasma membrane alteration to sustain survival of the cell (Fan W et al. 2019). Protein cross-linking followed by affinity purification assays detected the lipid raft-associated proteins flotillin-1 (FLOT1) and flotillin-2 (FLOT2) in membrane-localized MLKL immunoprecipitates isolated from human colon cancer HT-29 cells expressing MLKL fused with a 3xFlag-HA (in which MLKL fused with a 3xFlag-HA (hemagglutinin) tagged to its C terminus was expressed while endogenous MLKL was knocked down (Fan W et al. 2019). Mass spectrometry and immunoblotting assay identified showed that MLKL was associated with FLOT1 and FLOT2 within extracellular vesicles (EVs) released from caspase inhibitor z-VAD-fmk-treated HT-29 cells, suggesting that RIPK3 activation triggered MLKL association with flotillins (Yoon S et al. 2017). Phosphorylated MLKL was eventually directed to lysosomes in HT-29 cells immunolabeled with phospho-MLKL and LAMP1 (lysosome-associated membrane protein 1) antibodies (Fan W et al. 2019). Bafilomycin A1 prevented the degradation of phosphorylated MLKL only in parental HT-29 cells but not in cells lacking either flotillin suggesting that flotillins mediated the relocalization of phospho-MLKL from cell membranes to lysosomes (Fan W et al. 2019). However, the other study reported that phosphorylated MLKL did not colocalize to a significant extent with LAMP-2-containing lysosomes, and inhibiting lysosomal degradation during the effector phase of necroptosis did not significantly alter the extent of necroptotic cell death (Samson AL et al. 2020). Binding between the N-terminal helix bundle of phospho-MLKL and a C-terminal region of flotillin-1 was required for flotillin-mediated endocytosis of phosphorylated MLKL (Fan W et al. 2019). In addition, mice with a double knockout of Flot1 and Flot2 showed accelerated death upon injection with TNFα plus z-VAD-fmk to induce systemic inflammatory response syndrome (SIRS). Moreover, all flotillin-null mice survived TNFα/z-VAD-fmk-induced SIRS when coinjected with the RIPK1 inhibitor RIPA-56, confirming that the accelerated death in flotillin-null mice resulted from enhanced necroptosis (Fan W et al. 2019). Thus, phosphorylated MLKL is removed from membranes through FLOT1, 2-mediated endocytosis followed by lysosomal degradation (Fan W et al. 2019).

domain: literature