text:
Contributing to fight this battle is a group of five former students and colleagues from the UFS Department of Chemistry, now in the employment of Wildlife Pharmaceuticals. Situated in the Nelspruit area, Dr Inus Janse van Rensburg, Head of Research and Development; Lizette Janse van Rensburg, Head of Operations; Leo Kirsten, API expert; Dr Rikus Peens, API chemist; and Dr Chris Joubert, Laboratory Specialist, are working at this pharmaceutical manufacturing facility. The company specialises in the development, manufacturing, and end use of wildlife medicines.
With the medicines they develop, they are able to immobilise animals. Prof André Roodt, Discipline Head of the UFS Division of Inorganic Chemistry, who attended Indaba 9 with members of his research team in Skukuza, Kruger National Park, said wildlife species are being chemically immobilised for different reasons.
Prosecution of poachers
One example is of a rhino which was immobilised after a successful dehorning procedure by veterinarians and personnel of Wildlife Pharmaceuticals. As part of a programme to discourage poaching, selective DNA data collection is also conducted by some veterinarian groups for future use in the possible prosecution of individuals who are dealing with rhino horn. As soon as a rhino that was killed during poaching has been discovered, samples of the animal are obtained for a full analysis.
These samples are then stored on a database. Wherever rhino horn is confiscated (even internationally), the DNA is analysed, and the database may be consulted to see where the specific rhino was killed. The person in possession of the rhino horn may then be charged with the ‘killing’ of the original rhino.
Prof Roodt explained that the foundation of all medicines is based on active pharmaceutical ingredients (APIs) present in the finished pharmaceutical product, be it tablets, capsules, a syrup or a sterile injectable liquid. In accordance with local and international regulations and guidelines, chemists at API facilities are manufacturing these APIs globally.
The APIs are respectively incorporated into registered finished pharmaceutical products, which are then used by registered veterinarians for chemical immobilisation and reversal of immobilisation in wildlife species.
According to Prof Roodt, the importance of developing appropriate chemical agents and the role of chemical manufacturing are crucial for animal conservation, with a scope far beyond the field of animal immobilisation, thus extending it to animal health, treatments, and vaccinations.
Besides saving our rhinos, wildlife species require immobilisation for different reasons. This can include, for example, wound treatment, relocation, and surgical procedures. “It is critical that the animals be immobilised to ensure limitation of stress to the animal, mitigate self-harm, allow safe handling of the animal, and for operator safety. These activities will be impossible to execute without chemical immobilisation of the animal,” said Prof Roodt.
Dr Janse van Rensburg, who received his PhD in the UFS Department of Chemistry in 2008, said the department, through exposing its students to, among others, complex equipment in labs as well as work in international labs to critically assess and benchmark their work against others, contributed to the success of his career at Wildlife Pharmaceuticals.
Source: University of the Free State

domain: chemistry


text:
Haven't had time to play Metro 2033 yet? Want to catch up before Metro: Last Light hits? Now is your chance to do so.
Can't remember what this train nonsense is all about? Check outfrom when the game first arrived.
Metro 2033 available for £5.49 on Xbox Live
15 October 2012 | By Nick Akerman
- Related Games:
- Metro 2033

domain: hobby


text:
Define Reverse Mortgage Lanesboro MA 01237
The Disadvantages Of Reverse Mortgage Lanesboro 01237
As age captures up with senior citizens and their retirement gross nearer, senior citizens ought to start thinking of planning for the future. There is no doubt, some post retirement advantages will help seniors, however the quantity of money can be insufficient for some senior citizens to satisfy their monetary expenses for each month. Unless the senior is getting a substantial amount of loan for their retirement benefits, it is not likely they have the funds for a comfortable retirement that would allow them to travel and enjoy their silver years. All these financial requirements can easily be looked after my methods of a reverse mortgage.
people believe of ways in which they can add considerable quantities of cash to their retirement so they can live the life they have actually constantly dreamed about. Most senior citizens have actually seen advertisements of elderly couples traveling to exotic foreign locations beamed throughout the TELEVISION screen and they too wish to take part the fun and delight in life. There is a way to take those trips and have money without lots of troubles; the parties involved simply require to be at least 62 years of age to request a reverse home mortgage that can supply the senior with financial liberty by utilizing their house equity.
If you are an elderly person and are above 62 years of age and have a large quantity of equity in your home, a reverse mortgage can assists you in your post retirement dreams. After you receive the loan from the lending institution, you will not need to repay the loan as long as you reside in your home.ver, if you offer your home, you will need to repay the loan. The loan you receive from the loan is tax totally free and you maintain ownership of your home. In case of your death, the individual who inherits the home will need the loan if they decide to keep the home. A reverse home loan is not depending on your health, income or even credit rating.
Seniors might choose to utilize the funds to paying off their existing home mortgage, some may choose to utilize the loan for health care, or even day-to-day living costs. The fact that a reverse home mortgage permits elders to have their own monetary security and independence makes it a really popular option.
A reverse home mortgage can be rather costly due to the fact that the expense of the loan includes credit reporting charges along with appraisal and initiation charges, examination charges etc. add them completely they can amount to a significant quantity which is subtracted from the amount you will get. You must look for professional to assist handle the loan you get from the reverse home loan in mix with the rest of your funds if you do not appropriately handle your cash.
Reverse Mortgage Information Can Improve Homeowners’ Lives Lanesboro
What is a Reverse Mortgage?
It is a loan made to you utilizing your existing house as collateral. While this might sound like your basic home equity loan, it isn’t.
With many loans, you start paying back the obtained quantity not long after getting the lump amount distribution of loan. With this type of loan, nevertheless, you do not make any payments nor do you have to receive the loan in a swelling sum.
Rather, the amount of the loan is paid back once your house is offered or you die. Also, you can opt to have the cash distributed in month-to-month installations to offer you with extra living expenses.
Can a Reverse Home loan Advantage You?
Think of having the money to enjoy your retirement, pay off your debt, go on a dream getaway – these are the promises made by advertisements promoting this kind of home loan. They sound like an amazing opportunity however do they provide?
These home mortgages don’t have extremely rigorous rules about who receives them. The two crucial is that the youngest spouse is at least 62 years old and that you own your very own home.
If you currently have a home mortgage on your house, you can still qualify for a reverse home mortgage, too. The funds will be used to settle that existing loan initially and the balance will be dispersed to you.
Meeting those two criteria will enable you to get one of these loans, the amount of loan you are qualified to borrow is determined by your age and the worth of your home. You can never ever borrow more than exactly what your house deserves.
Debtors should also finish a therapy session prior to selecting this kind of loan. The function is to make debtors comprehend all the details and have actually thought about all of the offered options.
Exactly what are the Advantages and Benefits
Cash you can utilize as you desire – No lending institution will be hovering over you inquiring about how the loan will be or is being invested. You truly can utilize it for a dream holiday, medical expenditures, or anything else you desire.
It can be a security web – If you are at threat of losing your house due to foreclosure or a failure to pay your taxes, then a it can provide you with the funds required to protect your home or business.
You don’t have to stress about being a problem – As moms and dads of adult kids, you might fret that your health or monetary scenario might make you a concern on your household. This type of home loan can offer you a savings to guarantee that won’t occur.
In spite of the Benefits, There Are Some Drawbacks:
Your home can not be handed down to children – Due to the fact that the cash earned from selling your home will pay back the financial obligation, you will not have the ability to will the property to your kids. It will either need to be offered by your estate or it will revert back to the bank.
The upfront costs are high – When compared with other home loans, the upfront expenses of reverse home mortgages are much higher. While they can be funded with the remainder of the loan generally, these costs will all need to be paid back and will leave less funds readily available for your estate.

domain: economics


text:
Driver Web Design - DWD (now HutSix), is a team of digital experts specialising in building websites, applications and CRM software from the ground up. They provide fully customised digital solutions allowing for easy user operation, tailor-made to client needs.
Driver Web Design approached bellette to develop an original, eye catching campaign to showcase the ‘behind the scenes’ nature of their in-house coding.
They wanted to promote the message of catering for varying levels of client IT literacy - DWD maintain clear and easily understood communication in order to enhance clarity throughout their projects.
Thirdly, the brief contained a special request, ‘the boss's son wants to be Batman on TV’. .... thus the beginnings of memorable marketing moments can be born ...
This campaign had to avoid an overuse of the IT jargon that often bombards and overwhelms non IT based clients. Our team achieved this by embracing a lighthearted superhero campaign bringing a sense of humour to the serious nature of online system development.
The superhero campaign also played on the concept of ‘swooping in to save the day' - a frequent occurrence for DWD!
The bellette team utilised a green screen to cater for more freedom in regards to background animation, allowing for the dramatic, customised cartoon backdrop in post production.
Our camera operator also got to work with a very special model. Despite the industry saying, ‘never work with animals or children’! Exercising patience and keeping instructions clear and simple, meant our budding Batman could perform at his best.
This campaign was so successful, Driver Web Design came back to create an additional two superhero-themed campaigns featuring Spiderman and The Flash. These commercials raised the company’s profile, and create a welcoming space for any level of IT literacy.

domain: design


text:
There are lots of young guys joining the gay rent boys category, and this means a lot to the LGBT community. If the LGBT community is to stand a chance of one day being given the legal freedom to live how they want across the globe, it is very important to get young guys to join the movement. Else, as the current generation age, the community will quietly phase out.
I am one of those guys. I am gay, and for a long time, I have been looking at myself as abnormal because the world wants to keep us in the shadows. Something deep down always tells me that I am special. The movie “X-Men” has been a great inspiration to me. It thought me that being different is not a crime. I just had to find a way of harnessing my strength for good.
Like Wolverine, I have been looking for other gay people to connect with especially online because my dad will never approve of me associating with such groups. I finally found an LGBT community that had a lot of young guys online, and I joined. I easily made friends with some of them because of my extrovert and chatty nature.
Few months down the line one of the guys invited me to their meeting. It was in another city far from my home. Since I loved to attend, I needed a place to stay because I couldn’t tell my dad to give me money for such a trip. I raised my worries to my friend, and he agreed to let me stay with him.
I had enough savings to cover the expenses for the trip as well as feed me for a week. By the way, I was unemployed all these time not because there was no job but because I haven’t really found any that gave me the satisfaction I needed.
My friend was excited to see me. He was more handsome that the image I saw. From the moment of my arrival, he took me around the city and showed me a lot of interesting places. He would make a great tour guide, I tell you.
On the day of the meeting, we got dressed in a black tuxedo and went. Looking at us one would easily assume that we were gay rent boys because we looked as if we have known each other forever. I met some of the other guys that I have been chatting. The meet up was a huge success.
During the program, I was exposed to a lot of opportunities in the gay world. The most trending was working as gay rent boys. Exploring the opportunities, the freedom and the love I got from this community, I knew that I was never going back to my dad’s house. I called my dad and told him that I wasn’t going to come back.
“What’s the problem son?” he asked. I could sense worry in his voice. Since I didn’t agree with my dad on some grounds, I loved him and appreciated the impact he had made in my life.
“Dad it’s nothing bad. I just got a job, and the pay is good,” I said.
The tone of his voice changed instantly. His voice became more of enthusiasm. “Tell me about the job”.
I am pretty sure that my dad will be disappointed if I should tell him that I was working with gay rent boys. He never wanted to hear anything about LGBT in his house. “Ehmm…” I said as I thought of the answer I would give him. “I don’t have the full detail of the job now, but it is the service delivery sector. I will call you again when I have the full job description.
Till today whenever he calls, I would divagate. I guess he no longer thinks about it or he has given up asking because we now talk about other issues when I call. Working with gay rent boys have been a great relief. Besides the fact that it felt more like doing what I wanted other than just working for money, it has exposed me to the possibility of being whoever I wanted.

domain: sociology


text:
Vocaloid dating sim game deviantart
Places for dating in these dating games can vary from cheap local cafe to expensive restaurants, etc.You also need to give your date a gift and remember the answers your date gives to you. Building higher stats and a stronger relationship may help you reach this goal.The gameplay for guys and girls is not very different.If you are looking for something different, check out our other dating simulation games.Feel free to contact us if you have any game recommendations for our website or any feedback on the games.We would love to hear your suggestions and opinion since our goal is to make our site the best when it comes to both dating sims games and flash games in general.We hope you will enjoy our selection of sim dating games on Real Sim Games.Choose a category and enjoy hours of fun playing these flash games. If you are a girl looking for true love, our dating sims games are a chance to find it.
Simply select a game and start flirting with the men of your dreams. Kaito has only just noticed that he is broke, hasn't got a girl friend and is having no luck, when you happen to turn up!This is my first successful visual novel, I did not make any art, I just edited art I found on images into pngs suitable for this game.In most dating sim games you have a certain number of days to get together with someone, although there are some exceptions.Within given time, you have to build your stats and develop a relationship with someone from the game.
This collection of dating sims games will test your skills when it comes to seduction.

domain: entertainment


text:
We analyzed the endogenous nuclear 1,25-dihydroxy-vitamin D3 (1,25(OH)2D3) receptor (VDR) in rat osteosarcoma (ROS 17/2.8) cells and present biochemical evidence that it is a phosphoprotein. When ROS 17/2.8 cells are labeled metabolically with [35S]methionine, treatment with 10−8 M 1,25(OH)2D3 elicits a decrease in the electrophoretic mobility of immunoprecipitated VDR in denaturing Polyacrylamide gels, a property characteristic of phosphorylated proteins. Similar labeling of cells with [32P] orthophosphate results in a rapid (≤30 min), 1,25(OH)2D3-dependent incorporation of 32P into a 54-kDa VDR species that comigrates with the slower migrating receptor species extracted from [35S]methionine-labeled ROS 17/2.8 cells that have been exposed to 1,25(OH)2D3. Alkaline phosphatase treatment of immunoprecipitated VDR from 1,25(OH)2D3-treated cells converts the form of the VDR with reduced mobility to the faster migrating species present in 1,25(OH)2D3-deficient cells. Incubation of ROS 17/2.8 cells with the non-hypercalcemic 1,25(OH)2D3 analog, 22-oxacalcitriol (OCT), produces a level of VDR phosphorylation similar to that elicited by 1,25(OH)2D3 treatment. Transient transfection of osteosarcoma cells with a reporter vector containing a vitamin D responsive element derived from the rat osteocalcin gene yields equivalent transcriptional activation in the presence of either 1,25(OH)2D3 or OCT. Further experiments performed at various 1,25(OH)2D3 concentrations to assess the relationship between receptor phosphorylation and transcriptional activity in intact cells showed a positive correlation between these two parameters, indicating that the 1,25(OH)2D3 hormone stimulates VDR phosphorylation and transcriptional activation in parallel. Finally, highly purified casein kinase II (CK-II) phosphorylates the VDR in a 1,25(OH)2D3-independent, in vitro reaction. Comparison of the migration in denaturing gel electrophoresis of in vivo and in vitro phosphorylated VDR reveals a different electrophoretic mobility of the CK-II-phosphorylated receptor, suggesting that CK-II-mediated phosphorylation may be distinct from that occurring in response to 1,25(OH)2D3 or OCT. We speculate that hormone-dependent phosphorylation of the VDR may be required for transcriptional activation, while hormone-independent, CK-II-mediated phosphorylation may play a role in the modulation of receptor activity.
ASJC Scopus subject areas

domain: literature


text:
Sir Walter Scott
About the poet:
Born: August 15, 1771 in Edinburgh, Scotland.
Died: September 21, 1832 in Melrose, Scotland.
Scott was an internationally popular Scottish novelist, playright and poet in his time.
He went to live with his paternal grandparents at the age of three to cure the lameness he had as a result of polio. There his aunt Jenny taught him to read which helped inspire and characterize his early work.
Scott became a lawyer, married and had five children.
In 1796 his friend, James Ballantyne opened a printing press which allowed him to publish some of his first works and become known. He wrote many poems in the next ten years.
He was offered the postion of Poet Laureate in 1813 but turned it down.
He eventually became partner in the printing press but with a banking crisis in 1829 he went bankrupt. He was determined not to receive help but wanted to write his way out of debt. After he passed away his writing continued to sell and the debts on his estate were discharged.

domain: artistic


Redding hires new police chief
Longtime Redding Police Department employee and current Captain Roger Moore has been hired as Redding's new police chief.
Redding City Manager Barry Tippin said he was one of 19 candidates nationwide who applied for the job to replace Robert Paoletti, who left in June after serving as the chief for five years.
"He was the best-qualified candidate throughout the process," Tippin said about Moore. "His breadth of knowledge of the needs of the community set him apart."
The No. 1 issue Moore and the department face is dealing with the effects of Propositions 47 57 and how those affect crime in Redding, he said. Prop. 57, passed last November, allows more felons convicted of nonviolent crimes earlier parole and opportunities to get out of prison sooner on good behavior. But some, including many in law enforcement, believe the law will release violent criminals from the state's prisons and back onto the streets.
Prop. 47 reclassified some “non-serious, nonviolent crimes" as misdemeanors rather than felonies.
"We want to continue to develop a strategy where we would hold those accountable who are creating problems and continuing to commit crimes," Tippin said.
Moore said one of his top priorities will be to address the types of crime that affects residents' "quality of life."
He said his office will continue to aggressively enforce crimes such as public drug use, illegal camping, vehicle theft, burglary and residents being accosted outside work.
"I think the citizens want to focus on quality-of-life issues, and focus on the little things, right down to shopping carts" thefts, he said.
Over the past few months the department has conducted three "quality of life" sweeps, making dozens of arrests for outstanding arrest warrants and jailing people for things such as illegally camping and doing drugs in public.
Moore said the department will continue such programs. He also plans to reconfigure some of his resources, getting officers out on foot, on bicycles and off-road motorcycles to engage those breaking the law.
While the police sweeps have resulted in numerous arrests, most of those jailed are not held behind bars for long. Many are released within a day due to lack of space in the county jail.
Moore acknowledged the frustration with that, but said it won't deter his department from continuing to be aggressive.
More:Ex-RPD Chief Paoletti's departure cost Redding $140,000
"We are one gear in the criminal justice system and my job is to make sure my gear works," he said.
In addition to enforcement, officers will be handing out tickets to drug users and information pamphlets about where they can get services for drug and alcohol abuse, as well as mental health services, he said.
Vint Stevenson, a business owner in downtown Redding and one of the leaders of an effort to recall two Redding City Council members based in part on public safety concerns, said he was interested in finding out more about Moore's ideas on policing. Stevenson said he likes what the Police Department has been doing the past three months, aggressively patrolling area parks, the downtown and other crime hot spots.
"I look forward to seeing what his ideas are," Stevenson said. "I want to see them continue to focus on the positive momentum they have built."
More:City: Police chief leaves as leaders seek to go in new direction
Moore, 47, grew up in Redding, joined the force in 1995. He started working for the Shasta County Sheriff's Office when he was 19. After working for the Watsonville Police Department for several years, he returned to the Redding Police Department.
A holder of a master's degree in public administration, he is currently captain in charge of the department's patrol division.
He received the Police Medal of Honor in 2000 after he was shot three times while chasing a fleeing bank robber. He also received the Officer of the Year award and the Police Shield after being injured while on duty.
He received the Police Commendation Award for disarming a knife-wielding man in a crowded restaurant and got a Lifesaving Award for preventing a suicidal person from jumping off the North Market Street bridge.
He is tentatively set to take over as chief Sept. 24. Tippin said Moore's pay is still being negotiated, but the salary ranges from $8,729 to $13,796 a month.
Redding City Council member Kristen Schreder credited Moore with implementing the crime sweeps through parks and other areas of the city. She said those have been well-received by business owners and other residents.
People have noticed more of a police presence in downtown Redding, she said.
"They're being more responsive to the needs in our community," she said.
Jake Mangas, president of the Redding Chamber of Commerce, said he is optimistic that under Moore's leadership the city will thrive and his department "will help fulfill that promise to our residents and guests that Redding is a great place to be."
Mangas said he has had good interaction with Moore.
"We have definitely seen his leadership in action in terms of a greater presence of law enforcement in our community, and I would say a positive presence; so more of a proactive, getting out of that vehicle, walking around, visiting with the business community kind of presence," Mangas said.
Ed Rullman, who owns the Best Western Plus Hilltop Inn and leads the Redding Merchants Crime Watch group, said since Moore grew up in Redding and has been a longtime member of the police force, he won't need an orientation period to get to know the community and learn what the issues are.
"Great choice. He was born and raised here. He knows the city well," Rullman said. "He's lived in it. He's been a beat cop."
For Rullman, a top priority for the new chief should be to address the street-level criminal activity.
"Get people off the streets that don't belong there, the ones that are truly into criminal activity," Rullman said.
Shasta County Sheriff Tom Bosenko said he has known Moore for many years. His appointment will help the two agencies continue to work together and share limited resources. Bosenko said the Sheriff's Office assisted with the community sweeps and RPD assisted in a similar program conducted in Cottonwood in the past month.
"Given the size of our organizations, we all need to work in a collaborative relationship," he said.
Record Searchlight reporter David Benda contributed to this report.


text:
The living legend Sir Elton John is going on one last concert tour of his lifetime before he retires, The Farewell Yellow Brick Road Tour. Get tickets to see Elton John live on this tour in Minneapolis, MN from GoodDeedSeats.com, where you can not only purchase concert tickets, but you can also give back too. See https://gooddeedseats.com/elton-john-tickets/minneapolis-mn-target-center-02-21-2019.php
We make every effort to ensure the accuracy of this information. However, you should always call ahead to confirm dates, times, location, and other information.

domain: celebrity


Perhaps looking for a competitive niche among the morass of data service providers, in the wake of AT&T's Wednesday announcement that it would cap its data plans for wireless subscribers, Clearwire was quick to announce that it will keep offering its unlimited data plans.
The AT&T announcement has many analysts aflurry with speculation that other major providers like Verizon Wireless and Vodafone will soon move away from unlimited data offerings as well.
Clearwire may be better positioned than any other provider to capitalize on the data crunch. Its early moves into 4G, first installing WiMAX networks in select cities beginning in 2008 and continuing to add mobile broadband subscribers at a good clip, place it well ahead of other companies moving to 4G.
So, why does Clearwire's move matter to cable? For one thing, traditional cable operators can't wait to get into the mobile space and offer a quad-play service to their customers. Fiber providers including AT&T and Verizon are already skipping well ahead of cable in this area.
For another, cable operators well know that their established fixed-line networks can be used to augment a mobile broadband offering through VoIP-over-WiFi--if they can pull themselves together enough to implement the service. Time Warner Cable in April announced it was exploring the possibility of launching a VoIP service over Clearwire's WiMAX network.
- see this story
Abundant spectrum driving Clearwire's mobile broadband strategy
Time Warner may launch WiMAX VoIP offering
Who needs traditional cellular when WiFi can do the job?
AT&T goes where no cable operator can and offers quad play
Clearwire adds 87,000 WiMAX subs in 4Q


text:
The most common itinerary of the Grand Tour shifted across generations, but the British tourist usually began in Dover, England, and crossed the English Channel to Ostend in Belgium, or to Calais or Le Havre in France.
Where did people visit on the Grand Tour?
The traditional route of the Grand Tour involved arriving in Paris where tourists would bring or buy transport, and they would then cross the Alps carried by chair at Mont Cenis before moving on to Turin. Tourists would aim for famous festivals such as the Carnival in Venice or Holy Week in Rome.
What cities were part of the Grand Tour?
Turin, Florence, Rome, Pompeii and Venice would be amongst the cities visited, generally enticing those in to extended stays.
Which country were most commonly visited during the Grand Tour?
The most popular destinations were France, which meant Paris, and Italy. Italy held several important advantages over Paris.
What was the ultimate destination for those undertaking the Grand Tour?
In the 18th century the so-called Grand Tour became a rite of passage for aristocratic young men. The journey typically involved three or four years of travel around Europe and included an extensive sojourn in Italy, as Rome was considered the ultimate destination…
Has the grand tour ended?
There has been no confirmation that the show has been cancelled. Jeremy Clarkson confirmed that The Grand Tour will continue for at least another two seasons, despite fears the show my face the axe.
Where is clarksons farm?
Jeremy Clarkson’s farm – which he has lovingly named Diddly Squat Farm as a nod to his amateur farming status – is located in Chipping Norton in the Cotswolds. Clarkson’s Farm follows Jeremy being taught how to run his own farm by a group of local farmers and agricultural experts.
What was the Grand Tour of Italy?
Three hundred years ago, Italy’s “Grand Tour” was a journey made mainly by wealthy young people from Venice to Sicily, going through Tuscany, Rome or Naples, to discover the legacy of classical art and Renaissance Masterpieces.
Why is it called the Grand Tour?
The show’s name, The Grand Tour, was revealed in May 2016. Clarkson said the name brought to mind the tradition of Grand Tours, and reflected how the show would travel to several different countries to film.
What is the original Grand Tour?
The Grand Tour was a period of foreign travel commonly undertaken by gentlemen to finish off their education. It was popular from the mid-17th century until the end of the 18th century when the outbreak of the Napoleonic Wars stopped most foreign travel.
Who is father of Tourism?
Thomas Cook, (born November 22, 1808, Melbourne, Derbyshire, England—died July 18, 1892, Leicester, Leicestershire), English innovator of the conducted tour and founder of Thomas Cook and Son, a worldwide travel agency. Cook can be said to have invented modern tourism.
Was the pioneer of Grand Tour?
The Objectives of the Grand Tour
The German traveler Johann Joachim Winckelmann pioneered the field of art history with his comprehensive study of Greek and Roman sculpture; he was portrayed by his friend Anton Raphael Mengs at the beginning of his long residence in Rome (48.141).
Which is the longest established travel company in the world?
Almost a year to the date after it collapsed, leaving thousands of travelers stranded, Thomas Cook – the world’s oldest travel agency – is back. The 178-year-old operator has relaunched under its same famous name, but this time as an online travel agency under new, Chinese ownership, according to CNN.
How does the Grand Tour contributed in the history of tourism?
This became known as the Grand Tour. During the 16th and 18th centuries a standard itinerary was popularized. … The grand tourists visited famous ruins, architecture, fountains and churches. Admission to Greco-Roman statues and paintings included both private collections and museums.

domain: travel


text:
Campaign finance reports are coming in to Secretary Nelson's office. Scott Delzer has already submitted Russell Olson's [PDF]. Russ's campaign contributions so far (in-kind and cash): $59,984.25. That includes $10K from the state Republican party and another $10K from a couple other statewide Republican election committees (if I'm reading the report correctly). He's already burned up $37K on ads (putting your face on billboards is not cheap)... but he has another $22K left to spend. Expect your mailbox to be full.
More to come....
Indivisible 605 Sioux Falls event - Indivisible 605 Town Hall live from Icon Event Hall + Lounge Posted by Indivisible 605 on Thursday, February 23, 2017
2 hours ago

domain: news


text:
National Candy Day
National Candy Day is a celebration of all your favorite candies eaten by people all over the world. There are thousands of different types of candy, all with their own unique flavors, tastes and histories. Some of the more popular candies include gum, followed by chocolate. The first candy to be sold individually wrapped were tootsie rolls.
When is National Candy Day?
Type of Holiday?
Food, Fun Holiday
How is National Candy Day celebrated?
- Buy your favorite candy
- Invite friends over for some candy
- Swap candy with friends
National Candy Day Facts:
- The invention of the candy press was in 1847.
- The two top-selling candies in America have been M & M’S and Reese’s Peanut Butter Cups.
- M&M’s were first manufactured in 1941 and were given to American soldiers serving in the Second World War.
- Reese’s Peanut Butter Cups were first manufactured in 1928 by the Hershey’s company.
- The first candy is believed to have come to America from Britain and France.
- Americans over the age of 18 eat about 65% of all the candy produced each year.
- The average American eats 25 pounds of candy each year while the average person in Denmark eats 36 pounds annually.
- The best selling candy in the world is GUM, followed by the Hershey’s Kiss.
- Reese’s Peanut Butter cups make over $500 million annually – that’s a lot of chocolate.
- Tootsie Rolls is the U.S.’s first individually wrapped treat known as penny candy.
Popular Social Media Hashtags:
Celebrities who celebrate their birthday on November 4th:
- Diddy – Musician
- Matthew McConaughey – Actor
- Jessa Duggar – Reality TV Star
- Ralph Macchio – Actor
- Kathy Griffin – Comedian
- Jeff Probst – Survivor MC
- Bethenny Frankel – Reality Star – Real Housewives of NYC
- Doris Roberts – Actress
Do you have a favorite candy? What is it?
Check out other holidays in November here!

domain: food


This collection showcases Aotearoa Lesbian, Gay, Bisexual and Transgender screen production. The journey to Shortland Street civil unions, rainbows in Parliament and the Big Gay Out is one of pride, but also one of secrets, shame and discrimination. As Peter Wells writes in this introduction, the titles are testament to a — joyful, defiant — struggle to "fight to exist".
This stylishly high camp melodrama from directors Stewart Main and Peter Wells won acclaim, after debuting at the 1993 Cannes Film Festival. In the imaginary 19th-century town of Hope, draper Dorothea Brooks (Jennifer Ward-Lealand) is desperate to save her sister from the clutches of opium, sex and the dastardly Fraser. She begs hunky migrant Lawrence Hayes to help; but complications ensue. Inspired partly by 1930s and 40s Hollywood melodramas, Desperate Remedies was sumptously shot by Leon Narbey (Whale Rider). Richard King writes about the film here.
On Valentine's Day 2006 Shortland Street featured its first civil union, between lesbians Jay Copeland (Jaime Passier-Armstong) and Maia Jeffries (Anna Jullienne). The ceremony was aptly flush with pink decor and took place in Parnell’s Rose Gardens. Alas it was picketed by Serenity Church protestors and the union later ended — after Jay had an affair … with a man! In 1994 Shortland Street had earlier broken mainstream ground for the LGBT community with a lesbian kiss, between Dr Meredith Fleming (Stephanie Wilkin) and nurse Annie Flynn (Rebecca Hobbs).
Marching girls and boys, Camp Mother and Camp Leader and synchronised lawnmowers dance down Auckland’s Ponsonby Road in a celebration of gay pride. The theme of this edition of the (nearly) annual 90s street parade was Age of Aquarius, fitting given the heavy rain. The parade went ahead thanks to sponsorship from Metro magazine, after controversy when the City Promotions Committee declined the request for funding. The parade attracted 70 floats, and up to 200,000 spectators. Among those watching are Julian Clary and Shona Laing, who is one of the judges.
Part concept film, part biopic, part historical record and part comedy, Leanne Pooley’s documentary was made to mark the Topp Twins' 50th birthday. New Zealand's favourite comedic, country singing, dancing and yodeling lesbian twin sisters tell their personal story: from their 'coming out' to Jools' brush with breast cancer. The film features archive material, home movies and interviews with the Topps' alter egos. Alongside local box office success and dozens of international awards, Girls won the People’s Choice award for favourite documentary at the 2009 Toronto Film Festival.
Queer Nation was a factual series made by, for and about lesbian, gay, bi-sexual and transgender (LGBT) New Zealanders. Produced by Livingstone Productions with John A Givins at the helm, it screened on TVNZ for 11 seasons over nine years from 1996 till 2004 and was the world's longest running free-to-air TV programme made for the LGBT community. Long-serving presenters included original host (and future NZ On Screen ScreenTalk director) Andrew Whiteside, Libby Magee and Nettie Kinmott. Queer Nation won Best Factual Series at the NZ Television Awards 2003.
New Zealand's first lesbian web series follows three Wellington friends as they fumble their way toward love and acceptance. Producer Robin Murphy and director (and film school tutor) Ness Simons made the first episode in 2015 on a lean budget, followed by five more. in 2017 NZ On Air helped fund a second series. Pot Luck has attracted millions of unique hits, and featured at international web festivals. The cast includes Nikki Si'ulepa (actor and director of Salat se Rotuma - Passage to Rotuma), Tess Jamieson-Karaha (Births, Deaths and Marriages) and Brit import Anji Kreft.
Georgina Beyer was the first transgendered person in the world to be elected to national office. Co-directed by Annie Goldson and Peter Wells, this internationally lauded documentary, tells the story of Beyer's extraordinary, inspiring journey from sex worker to member of Parliament for rural Wairarapa, and handshakes with the Queen. Born George Bertrand, Beyer grew up on a Taranaki farm, before spreading her wings on Auckland's cabaret circuit. Subsequent events led her to the town of Carterton, where she became involved in local body, and then national politics.
"...I mean to say, shouldn't I be in love with a fella or something?" Mandy (Richard Hanna), a man who dresses as a woman, describes his relationship with transsexual Jewel (future politician Georgina Beyer). Jewel's Darl concentrates on the fine details of their relationship: tea and biscuits in bed, Jewel's belief in staying strong against other people's mockery, and Mandy's memories of a troubled childhood. Nominated for multiple NZ Film and Television awards after finally getting a TV slot, Peter Wells' drama was inspired by an Anne Kennedy short story, which won the 1983 Katherine Mansfield Award.
Luscious fruit, truckies, and Lucy Lawless feature in this Christine Parker short. Sal (Tania Simon) is gifted a peach and meets a saucy tow truck driver (Lawless) en route home to her toddler, and domestics with boyfriend Mog (Joel Tobeck). Mog’s truckie mates arrive for beers, including the nameless driver, whose presence (and peach-eating advice) stirs up desire. “Watch it rot, or taste it when it’s ripe.” A roster of leading NZ film talent worked with Parker on the film, and Lawless' turn hints at the cross-sexual appeal of her breakthrough role on Xena - Warrior Princess.
In more repressed times, Carmen was one of NZ's most colourful and controversial figures. Geoff Steven's doco traces the life story of the transgender icon who was born Trevor Rupe in Taumarunui in 1936 and went on to be a dancer, sex worker, madam, cafe owner — and one of the few non-MPs to appear before the Privileges Committee. Steven shines a light on a bygone era of gay culture but avoids the temptation to focus on the seedy — opting, instead, for extended fantasy sequences (featuring Neil Gudsell aka Mika) to illustrate key moments in Carmen's life.
Peter Wells and Stewart Main’s acclaimed drama screened in primetime and was ground-breaking in featuring AIDS. Wells' script is based on the death of one of his friends — one of the first New Zealanders to die from the disease — but the living are the focus, as Wells creates an intimate “strange and foreign land” occupied by those close to someone who is dying. Andy’s friends confront both their own mortality and the deadly new disease stalking their community, while his conservative family grapples with never having come to terms with his sexuality. The excerpt features the opening 10 minutes.
They came, they battered, they bickered. Peter Hudson and David Halls were as famous for their on-screen spats as they were for their recipes. The couple ("are we gay - well we're certainly merry") turned cooking into comedy. Their self-titled show ran for a decade on New Zealand TV and it attracted a cult following when they moved the show to the UK. The duo won Entertainer of the Year at the 1981 Feltex Awards. Microwaves, little roasted nuts and great dollops of innuendo: the sometimes fusty genre of TV culinary demonstration would never be the same.
Lew Pryme's life was a wild ride that took in everything from rock and roll to rugby before it was cut short by AIDS in 1990 (he was 51). This moving documentary interviews an ailing Pryme reflecting on his journey and (still secret) sexuality; it follows him from Waitara to becoming one of the most popular hip-swinging music stars of the 60s. He went on to manage singers Mark Williams, Rob Guest and Tina Cross; and in the early 80s he became the first executive director of Auckland Rugby Union, introducing cheerleaders and 'pizazz' to Eden Park.
When Love Comes features Rena Owen as a once were famous singing star who returns to NZ, in need of reinvention. Staying with a close gay friend (Simon Prast), she is reenergised after meeting a wastral songwriter (Dean O'Gorman) and two loved up young musos (Sophia Hawthorne and Nancy Brunning, the former in her big screen debut). Invited to a slew of North American festivals — including Sundance and Toronto — Garth Maxwell's sun and song-lashed tale won stateside praise for its "energetic direction" (The Hollywood Reporter) and impassioned performances.
City Life screened from 1996 to 1998 and made a direct appeal to New Zealand's Gen X apartment-dwelling demographic. Following the lives of a tight-knit group of friends, and featuring racy shots of Auckland's K-Road and nightlife set to contemporary Kiwi pop music, the show was Aotearoa's answer to Melrose Place. In this excerpt from the first episode, the friends are thrown into conflict when one of their own (played by Kevin Smith) decides to marry outside the circle. Complications ensue when Smith shares a brief, but notorious, screen kiss with Charles Mesure.
Takatāpui was the world's first indigenous gay, lesbian and transgender series. Produced by Front of the Box Productions and screening on Māori Television for six series, the show was magazine-styled with a Māori queer focus (it was replaced by the Wero series). It was light entertainment but not afraid to delve into some hard-hitting issues affecting the takatāpui communities all over New Zealand. Presenters included transgender singer Ramon Te Wake, Taurewa Biddle (with his distinctive moko) and Tania Simon.
Tala Pasifika was a pioneering Pacific Island drama series; this award-winning episode is one of six films that screened on TV One in 1996. 'Talk of the Town' is an entertaining short drama about Cindy (Henry Ah-Foo Taripo), a fa'afafine who has grown up to become a cabaret performer. She breaks the fourth wall from her dressing room to tell her story, which begins in her youth when her father (Alvin Fitisemanu) is impressed by her culinary skills and assigns her to the role of family cook.
"I do hope your pimples don't let you down on the big night." 14-year old Steve is caught between creatures he does not fully understand: two parents with very different ideas about the suit he should wear to his first school dance. Meanwhile everywhere he seems to look, images of men are taking control of his imagination. In Stewart Main's comical coming of age story Steve escapes his parents' good wishes, to discover his true desires. They aren't quite what his no-nonsense father had in mind.
This TV documentary sees director Peter Wells look at his life “through pansy-tinted glasses”. Motivated by the anniversary of his brother’s 1989 death (from AIDS) Wells’ film charts his path to becoming a pioneering gay filmmaker and writer: from growing up fascinated by colour and the glamour of royalty in conservative Port Chevalier in the 1950s, to baking, and deciding to come out when he was drafted to fight in Vietnam. As befits an artist whose credits include Desperate Remedies, the treatment is distinctive: a mixture of documentary, (aptly) flowery home movie, and quiet reflection.
Set in Central Otago in the drought-parched summer of 1975, gay-themed feature film 50 Ways of Saying Fabulous follows a chubby 12-year-old named Billy (Andrew Paterson) as he embarks on a challenging journey of sexual discovery. Adapting Graeme Aitken's novel, writer/director Stewart Main (Desperate Remedies) depicts a boy escaping into fantasy from the drudgery of farming duties — and learning about himself, his sexuality, and dealing with change. 50 Ways won a Special Jury Award at Italy's Turin International Gay and Lesbian Film Festival in 2005.
Richard Turner made Squeeze to break the "conspiracy of silence" about homosexuality. A pioneering early portrait of Auckland's LGBT scene, Squeeze centres on the relationship between a young man (Paul Eady) and the confident executive (Robert Shannon) who romances him, then mentions he has a fiancée. The film was discussed in Parliament after Patricia Bartlett campaigned against the possibility it might get NZ Film Commission funding (it didn't). Kevin Thomas in The LA Times praised Squeeze's integrity and the "steadfast compassion with which it views its hero".
'Sui generis' is a Latin expression meaning "the only example of its kind, unique". This second edition of the anthology web series explores romantic life for Auckland’s LGBTQIA+ community in the second decade of the 21st century. Each episode is stand-alone and ranges in location from fancy dress parties, to Grindr hook-ups – "the connective tissue of each story is technology, apps and dating." These three episodes range from a tender romance which contains a surprise, to dating as dance routine, to a quirky encounter at a party. Warning: contains adult themes.
Astronomy-obsessed worrier Richard meets part-Italian Johnny, a man whose idea of a holiday involves breaking into the nearest bach. Pitched at gay and straight alike, the pair's lighthearted but occasionally troubled romance featured extensive footage of central Auckland circa 1988 (courtesy of director Garth Maxwell’s own central Queen Street digs), plus images of space — for Richard a place of both beauty and potential disaster. Beyond Gravity won local theatrical screenings, and a scriptwriting award in France. This excerpt features the opening 10 minutes of the 48 minute film.
Australian diva Kylie Minogue is in New Zealand to promote her 1997 Impossible Princess album in this interview for the Queer Nation TV series. Filmed in an Auckland hotel room, Libby Magee asks the pint-sized gay icon why ‘the boys’ love her and whether she’s ever kissed a girl. Kylie talks about Royal Albert Hall collaborations with Nick Cave and Elton John, what it’s like to snog Jason Donovan, and needing to wear heels while performing at Sydney’s Mardi Gras: “Most of the Kylies here are about seven feet tall!”. Kylie finishes by coming out of the closet.
Crush is a tale of simmering sexuality set in Rotorua. Moral or sexual ambiguity pervades the narrative of conflicted desire. Its mix of blocked-up writer, spurting mud-pools, infatuated teen, eel farm, American femme fatale (Marcia Gay Harden), noir motels, limp pongas and wheelchairs, plays out in a symbolic NZ landscape not seen before (or since). Director Alison Maclean's debut feature (which she co-wrote with Anne Kennedy) played in competition at the Cannes Film Festival.
One of Them! was one of two dramas (alongside Niki Caro movie Memory and Desire) inspired by short stories collected in Peter Wells' 1991 book Dangerous Desires. It was made for TV One as a Montana Sunday drama. Set in Auckland, 1965, One of Them! follows Lemmy and Jamie, two teenage boys coming to terms with their sexuality. In the dark days before gay liberation, bullying and intimidation was rife, and while the boys flaunt their sissyness, their internalised homophobia wreaks havoc on their emotional lives — until they can admit to being "one of them".
This romantic feature is inspired by the couple behind the camera. Kiwi-Samoan filmmaker Nikki Si’ulepa (Snow in Paradise) and Rachel Aneta Wills have dramatised their bumpy journey towards marriage and put it on the big screen. Pākehā single mum Rachel (they’ve kept real names) meets Samoan filmmaker Nikki and is immediately drawn to her, but self-doubt, botched communication and a pesky ex are landmines in wait. Director Si’ulepa wanted to "offer a glimpse into same sex relationships" and tell a "true, romantic love story that people can relate to".
After success with short films (This is Her, Redemption) director Katie Wolfe made the transition to longer length story-telling with this 2010 drama. With This is Her writer Kate McDermott she adapted the Witi Ihimaera novel about a 40-something man confronting his double life, and the impact that his coming out as gay has on his wife, kids, and whānau. A key change was turning the book’s Pākehā protagonist to a successful Māori businessman (Calvin Tuteao). It screened on TV One on 23 January 2010 and at festivals internationally (where it was entitled Kawa).
Haunting Douglas is a documentary portrait of dancer and choreographer Douglas Wright. It weaves interviews with footage of past performances, and extracts from his autobiography; from drug addiction and illness, to determination and triumph on the New York stage with the Paul Taylor Dance Company. Award-winning director Leanne Pooley captures Wright's resilience: "I need to make things to feel that I can cope with whatever reality is. For me, dancing, performing for people, is the ultimate mystery and the ultimate joy." Wright passed away in November 2018.
This documentary traces the life of intersex activist Mani Mitchell. 'Intersexual' is a term to describe a person with atypical combinations of the biological features that usually distinguish males from females. Mitchell's harrowing but ultimately inspiring story is told via candid and articulate interviews, as Mitchell talks about being made a "hospital freak show tour" by doctors, and growing up secretly 'middlesex'. The Dominion Post's Jane Bowron called Mani's Story "one of the great survivor stories". It won the 2004 Qantas Media Award for Best Documentary.
In Boy, a college-aged rent boy exposes the truth about the death of a girl in a hit and run accident. Using typography that hovers on screen in place of dialogue, flares of bold colour, dioramic frames, and brutal portraiture reminiscent of Dianne Arbus, director Welby Ings creates a powerful, exquisite perspective on the silent claustrophobia and sexual violence of small town New Zealand. The film gained acclaim both at home and internationally. Accolades included Best Short Film at Cinequest in the United States.
In this short film Peter Wells makes a personal 'Postcard from New Zealand' as part of a series for England's Channel Four. Looking for a "Kiwi Greek god" to showcase his "Gay Lynn" garden, he enlists Richard, third place getter in Mr Gay Auckland. While posing Richard tells them about his costume for the Sydney Mardi Gras. "Skirt in the shape of Rangitoto, a hat like Auckland's Harbour Bridge: Dame Edna would've loved it". Richard models the costume which also features budgie smugglers with 'NZ' sequined into them, a Southern Cross singlet, and ugg-glove sheep puppets.
Arts magazine series For Arts Sake screened on TV ONE for two hours on Sunday mornings for 22 weeks in 1996. This segment on dancer and choreographer Michael Parmenter features an in-depth interview with Parmenter (by series presenter Alison Parr) and excerpts from his dance works. Parmenter talks about his creative influences, his tough upbringing in conservative Invercargill, the tensions caused by being gay and in the Brethren Church when he was younger, and the impact of his illnesses (HIV and cancer) on his life and dance career.
This award-winning short revolves around a Māori women’s rugby team. Rising star Phoenix (newcomer Ngawaea Taia) has to negotiate motherhood, her mateship with the crusty old coach (veteran Roy Billing), and her feelings for the captain (Maria Walker). Directed by Tim Worrall, and filmed in his Rotorua hometown, the short was one of six selected by director Christine Jeffs for 'New Zealand’s Best' at the 2015 NZ International Film Festival. Jeffs praised the film as "realistic and full of feeling". Worrall won Best Short Script at the 2015 SWANZ (NZ Writers Guild) Awards.
Is it a boy? Is it a girl? What if it’s neither? This award-winning documentary explores the world of the intersexed (formerly known as hermaphrodites) — those born with any one of 30 conditions that make their gender ambiguous. Presenter Mani Bruce Mitchell — New Zealand’s first ‘out’ intersex person — and director Grant Lahood had to travel overseas to find interviewees who would talk freely. They discuss living in a society with a binary view of gender which, at best, has made them all but invisible; and, at worst, has subjected many to damaging “corrective” surgery.
On 1 July 2001, John Scott and his partner Greg Scrivener were killed in their home in Suva. John, from an old European-Fiji family was the Director-General of the Fiji Red Cross and worked as a go-between in the hostage crisis during the 2000 coup. The documentary traces the colourful story of the Scott family, the political crises that have marked Fiji's recent history, the killings and their aftermath, and the complex mix of tribal authority and democracy. It won best documentary and camera gongs at 2008 Qantas Film and Television Awards.
Mystery and menace abound in this debut film from Alison Maclean (Crush, The Rehearsal). Made when Maclean was an Elam art student, the experimental short plays with gender and racial stereotypes by constantly thwarting narrative expectations. What there is of a plot consists of a woman emerging from the sea and a 'centrepiece' pursuit leading to a confrontation between two characters: a man and a woman. Scripted, shot and edited by Maclean, it marked the beginning of a fertile collaboration between Maclean and producer Bridget Ikin.
Filmmaker Stewart Main traverses India seeking enlightenment. There he meets ex-pat Kiwis who seem to have found it, which only leaves him feeling trapped in a life of the senses. Especially when he falls for his Indian sound recordist, Sreenu. Or so he would have us think. Made for TVNZ's Work of Art documentary slot, Main's startling, provocative film explores the cracks between the divine and the sensual, documentary and fiction. Director Andrew Bancroft writes about the result in this backgrounder.
In the 1970s, New Zealand artist Allie Eagle identified herself as a lesbian separatist and radical feminist. Her often uncompromising work included pro-abortion painting This Woman Died I Care, which was inspired by a photograph of a woman who died from an illegal abortion. In the 1980s, Eagle became a christian. Made in 2004, Briar March's first, feature-length documentary sees Eagle reflecting on her past with a more moderate outlook — she now has mixed feelings about her earlier stance on abortion.
Tash Keddy made history in March 2016 as the first transgender actor to play an ongoing transgender role on New Zealand television — joining Shortland Street to play Blue Nathan, a teenage girl who identifies as a boy. Keddy trained in fine arts at Elam before winning the role. In this short interview and accompanying clip from the show, Keddy recalls Blue's dramatic onscreen arrival in the corridors of the hospital. “I really liked my entry storyline ... Blue came in in this huge bundle of energy and stole stuff and punched someone, and had a scuffle".


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Disruption on Grand Central Trains between Sunderland and Kings Cross, and between Bradford Interchange and Kings Cross due to overhead line problems at St Neots.
Tickets are being accepted on East Midlands Trains services.
Trains are not able to run between Peterborough and London, disruption will be ongoing for the whole of today.
A replacement bus service is running between Peterborough and London.
Also affecting First Capital Connect, East Coast and First Hull Trains.
More top news
A look at the forecast for the Tyne Tees region.
ITV Tyne Tees investigates just how easy it is to get hold of legal highs and reveals exactly what chemicals are contained in them.
Police are appealing for witnesses after a man's body was found in a South Shields back alley.


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Purpose of review: Protein requirement in healthy young and old individuals is traditionally defined as the lowest protein intake sufficient to achieve neutral body protein balance. This concept, however, cannot be applied to those conditions characterized by unavoidable protein catabolism despite optimal nutrition, such as inactivity and diseases associated with systemic inflammation.
Recent findings: The ability of dietary proteins to promote protein anabolism is reduced by inactivity and inflammatory mediators, whereas physical exercise ameliorates the efficiency in using dietary proteins. Consequently, the protein intake level associated with the lowest rate of catabolism in inactivity and/or inflammation is greater than the minimum protein intake required to achieve neutral protein balance in healthy, physically active individuals. A protein intake of 1.2 g.kg.day is currently recommended for inactive healthy individuals, whereas guidelines recommend up to 1.5 g.kg.day in patients with severe systemic inflammation, such as those affected by critical illness or cancer. High protein intake accelerates progression of renal insufficiency but does not affect renal function in healthy individuals.
Summary: In inflammation and/or inactivity a relatively high protein intake may be required to promote synthesis of specific proteins, prevent depletion of selected amino acids (e.g., glutamine or arginine), modulate immune functions, counteract insulin resistance and redox unbalance. Thus, an optimal protein/amino acid intake may be greater than that required to decrease whole body protein wasting.

domain: biology


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The Senate Appropriations Committee for the Departments of Labor, Health and Human Services, Education, and Related Agencies has released their FY2021 funding recommendations, which for the second consecutive year includes report language directing the National Institutes of Health (NIH) to support celiac disease research.
Beginning with CEO Marilyn G. Geller’s 2019 testimony to the House and Senate Appropriations Subcommittees, the Celiac Disease Foundation has been boldly advocating for NIH to develop a strategic plan to find a cure for celiac disease. The FY2021 appropriations report language provides detailed instructions on how NIH is to continue to proceed with the study of celiac disease.
The Senate language is companion to the already passed House Appropriations report language on celiac disease and reads:
“The Committee includes sufficient funding for NIH to devote focused research to the study of Celiac disease, including the autoimmune causation underpinning the affliction. Today, the only known treatment for this disease is a gluten-free diet; however, recent public and private sector research has revealed that such a “treatment” is insufficient for many who suffer from Celiac disease. Therefore, the Committee urges NIAID to support new research on celiac disease to better coordinate existing research and focus new research efforts toward causation, and ultimately, a cure of this disease. The Committee encourages NIAID to coordinate with other Institutes and Centers including NIDDK as appropriate and to submit its plan for coordination and execution of this research to the Committees on Appropriations of the House of Representatives and the Senate no later than 90 days after enactment of this act.”
The House language reads as follows:
“The Committee supports NIH research on celiac disease, including the autoimmune causation underpinning the affliction. Today, the only known treatment for this disease is a gluten-free diet, but recent research reveals that this strategy is insufficient for many who suffer from celiac disease. The Committee urges NIAID to support new research and to better coordinate existing research with NIDDK and the other Institutes and Centers. The Committee requests that NIAID report back in the fiscal year 2022 Congressional Justification on the progress made towards promoting, recruiting, and supporting additional celiac-focused research.”
In response to the House and Senate requests for NIH to support new celiac disease research, the National Institutes of Health will convene experts from around the country to a virtual workshop entitled “Accelerating Progress in Celiac Disease,” on March 18th and 19th with the intent to release a Notice of Special Interest in order to spur additional celiac disease research.
Click here to stay informed by signing up for our Advocacy email alerts.
Senate Releases FY2021 Language Directing NIH to Study Celiac Disease

domain: medical


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The Charleston RiverDogs split their road series with the Rome Braves after dropping the last game of their four game set 6-5 in an 11 inning walk off Sunday afternoon.
The Braves again got out to an early lead which was the norm in this series, RiverDogs starter Justin Kamplain gave up a three spot and couldn’t get out of the second inning. Kamplain went an inning and two thirds surrendering four hits and two walks with all three runs being earned.
The Braves cruised into the sixth when the RiverDogs finally broke through and scored a run. Miguel Andujar lead off the inning with a single and came around to score on an Eduardo de Oleo sacrifice fly to make the score 3-1.
The RiverDogs made a run at a comeback and started off the eighth inning with three consecutive singles to bring the RiverDogs within one. Mike Ford drove in Tyler Wade for an RBI, Ford then scored on a one out RBI single from de Oleo to tie the score at 3-3.
Yeicok Calderon finished the eighth inning with a two run home run to right field to give the RiverDogs a 5-3 lead with only six outs from taking three out of four games.
Conor Mullee couldn’t hold the lead in relief though as two batters into the bottom of the eighth the Braves tied the game up on a Sean Godfrey home run to left field to knot the game again at 5-5. The game would end up going into extra innings and the RiverDogs had their chances to win.
In the 10th inning Andujar and Ford were both cut down at the plate on fielders choice plays to get the second and third outs and got out of a bases loaded threat.
Evan Rutckyj came on in relief of Mullee in the ninth inning and was pitching well until two infield singles set up the Braves with first and third with one out in the bottom of the 11th. Braves third baseman Connor Lien singled in the walk off run and gave the Braves the win.
The RiverDogs (58-62) are back at it Monday night as they return home to begin a three games series with the Hickory Crawdads.
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domain: game


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About Our Auction
As writers of crime fiction and nonfiction, we are empathetic people who have the power to imagine a better world. Let’s help build one by rewriting the histories assigned to unjustly convicted persons. Let’s write a better, more just ending.
We're working to raise $35,000 for Innocence Project, a non-profit that works to free the innocent, prevent wrongful convictions, and create fair, compassionate, and equitable systems of justice for everyone.
If you'd like to make a donation (without bidding) go to: https://secure.actblue.com/donate/crimewritersjustice
About Sisters in Crime
Sisters in Crime (SinC) is an international, inclusive community for all who write and love crime fiction, mystery, thrillers, and suspense.
Our Crime Writers for Justice initiative is composed of authors who are committed to a fair justice system. One way to improve our current criminal justice system is to help free innocent people convicted of crimes. We aim to raise $35,000 for Innocence Project and help rewrite the lives of innocent people currently incarcerated.


State Significant Development Approval (SSDA) Community Drop-in Session
A State Significant Development Application is being prepared by Waverley College for the construction of a new building, and staged upgrades to existing facilities over 10 years.
We are in the early stages of planning and designing the proposed updates to the school. Community involvement will be central to the development of this project.
To find out more, please attend our Drop-in Session on Tuesday, 19 March, 4pm-7pm in the Performing Arts Centre Foyer, 131 Birrell St, Waverley, or email us at firstname.lastname@example.org
You can visit the Waverley College Stage 1 Master Plan webpage HERE.
Mr Simon Potter
Director of ICT, Campus and Innovation


Please note that, because of growing public health concerns, some events may be cancelled on short notice.
- This event has passed.
Facebook Live Town Hall: Yousef and You
March 28 @ 10:00 am
From Rep. Rabhi:
It is important to me to know what your priorities and opinions are, so that I can better represent you. In lieu of our normal in-person Saturday discussion at RoosRoast, I will be hosting a virtual Yousef and You discussion on Saturday, March 28 at our normal time, 10:00 a.m. I will provide an update on state action around the outbreak of COVID-19, as well as other legislative action. My staff and I will try to answer your questions as best we can. Please visit my Facebook page on Saturday morning to tune in! Details below:
Disclaimer: One of the WCDP’s goals is to promote causes, activities, and events spearheaded by community members and like-minded organizations. With that said, the views and opinions expressed by individuals or organizations on our News and Calendar pages are not necessarily those of the Washtenaw County Democratic Party or its leadership. Similarly, events related to candidates and their campaigns are not endorsements.


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ABOUT CULTURAL CLUB
The Cultural Club aims at moulding the personality of students and exposes them to a wide range of cultural events throughout the year. ... Along with giving a platform to creativity, the Club aims at developing the intellectual, organizational and social skills of the students.
OBJECTIVE OF THE CLUB
1.There is abundance of cultural talent in the college premises and the Cultural club provides platform for those talents to flourish.
2.Promote opportunities for everyone to experience culture, participate in educational programmes and develop their creative abilities.
3.Promote quality and artistic renewal.
4.Promote a dynamic cultural heritage that is preserved, used and developed.
6.Pay particular attention to the rights of young people to culture.
7.To help the students to know them self better their interests, abilities, aptitudes and opportunities.
8.To encourage and develop special abilities and right attitudes.
cultural Fest-30-11-23 Registration click here


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Ace Fishing: Wild Catch is a sport fishing game that is fun especially for those who enjoy fishing and even those who wouldn’t actually like the sport. After just a few minutes of playing, the game will quickly reel in your interest. The good graphics and appealing animations are the first and most obvious assets. The water waves are as lifelike as they are enthralling so they have obviously been a priority from the design side. The fish also have an appealingly pleasing look and are truthfully animated.
It is very easy to handle and become accustomed to for controls. Cast the bait by tap the center icon and reel in the fish by holding it. If the tension gets too high, release it. While at one go ensuring that the fish should not escape if it get too far away, make sure you won’t make the string will break by apply too much pressure. When rare, more costly fish bite the bait, this can become more and more challenging. There is a combo system in Ace Fishing: Wild Catch to help players in attempting such events. It will add to the combo meter bringing close to max the tension and releasing right before the string is almost to break. It also works working to retain reeling in for 5 sequential spins. By a huge distance, you can swipe to pull the fish nearer once full.
Ace Fishing: Wild Catch is more involving the real catch though there is much waiting and patience in real fishing. There is no searching for locations and it is more likely to be filled with fish. You will find better fish by unlock new locations by leveling-up. You will also help raise the probabilities of finding rare fish by Upgrading gear and purchasing enhanced bait. Diverse types of equipment that can be purchased and huge variety of realistically animated fish can be discovered in the game. You can sell fish right away once you catch ones, or you can wait and store in tank until it fully grown to sell for a higher value. In-app purchases are available allowing you to spend real money for greater gear and packs of cash or you can compete in frequent events to get money.
However, there are a couple of downsides in Ace Fishing: Wild Catch as it is a freemium game. There is a durability limit in a lot of the items that are purchased so you will need to refill it. The player’s energy is also limited set to 15 games but upon leveling up the bar gets replenished. You won’t run out of energy going through the first 6 levels so this game is much better balanced freemium games in the app store.
It’s absolutely obvious that the developers have tried to make it as different as possible although for a free-to-play simulator, Ace Fishing: Wild Catch has a really standard gameplay value. Ace Fishing is rather realistic as it is a contrast thing having any kind of realism in a free-to-play simulator game. This makes the game is fun and appealing although you do not like fishing.


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Thin film solar is becoming an increasingly important segment of the solar industry. Thin-film solar cells consist of layers of active materials about 10 µm thick compared with 200- to 300-µm layers for crystalline-silicon cells. Some sixty companies have announced to start thin film production by 2010, and EuPD Research estimates that by then, the production output will amount to 3.5 GW. According to the EIA, in 2006 thin film represented a 30% share of the of the 337,268 Wp of photovoltaic cells shipped by the U.S. solar industry, as compared to 12% in 2004. in 2007 total solar (including solar thermal) represented less than 1% of the total of all renewable energy [including biomass (53%), hydroelectric (36%), geothermal (5%) and wind (5%)] which in turn represented just 7% of total energy consumption in the U.S. Cadmium telluride PV (CdTe PV) is the only thin film photovoltaic technology to surpass crystalline silicon PV in the marketplace, in terms of lower system price, for a significant portion of the PV market.
First Solar, Inc. (Nasdaq: FSLR), producer of Cadmium Telluride (CdTe) PV modules, is the largest manufacturer of thin film solar modules, expanding manufacturing capacity to an expected 735 MW in 2008; and with additional plants under construction, First Solar will bring total expected capacity to more than 1 GW by the end of 2009.
At the end of 2007, over 300 MW of First Solar PV modules had been installed worldwide and First Solar expects to ship 420 to 460 MW of PV modules in 2008.
First Solar announced on October 29 groundbreaking for the expansion of its Perrysburg, Ohio facility which will increase the annual capacity at the facility to approximately 192 megawatts. Plant construction is expected to be complete by the first half of 2009, with full volume production expected by the second quarter of 2010.
On the same date First Solar, Inc. and SolarCity Corporation announced a module supply agreement and investment that will make solar power an affordable option for more U.S. homeowners and businesses. The two companies have entered into a five-year agreement that calls for First Solar to supply 100 megawatts of its thin film solar modules to SolarCity, marking First Solar's entrance into the U.S. residential segment. Pursuant to the agreement, First Solar will begin delivering modules to SolarCity in the first quarter of 2009. First Solar will also make a $25 million equity investment in SolarCity; part of a $30 million round of financing that will fund SolarCity's continued U.S. expansion. SolarCity's innovative SolarLease(TM) financing option allows homeowners to switch to solar power for less money than they currently pay for electricity from their power company, without the need for a large upfront investment.
First Solar is the cost leader in the solar PV industry. First Solar has the lowest manufacturing cost per watt in the industry, $1.08/watt for the third quarter of 2008. Future module costs well below $1.00/Wp have been predicted by NREL
The modules are manufactured on high throughput, automated lines that integrate each production step, from semiconductor deposition to final assembly and test, in one continuous process.
The use of CdTe produces high energy yield across a wide range of conditions. The efficiency of this semiconductor material is less susceptible to cell temperature increases than traditional semiconductors, enabling First Solar thin film modules to generate relatively more electricity under high ambient (and therefore high cell) temperatures. The semiconductor material also converts low and diffuse light to electricity more efficiently than conventional cells under cloudy weather and dawn and dusk conditions. As a result, First Solar thin film modules will generally produce more electricity under real world conditions than conventional solar modules with similar power ratings.These attributes have led the National Renewable Energy Laboratory in Golden, Colorado to recognize CdTe's potential for achieving the lowest production costs among current thin film technologies. (Photon International, November 2004, page 50). As a result, future module costs well below $1.00/Wp have been predicted by NREL.
Both cadmium and tellurium are byproducts of the mining and production of base metals such as zinc and copper. First Solar claims these materials are present in abundant quantities to support multi-GWs of annual production.
Their largest project to date, shown at begining of post, is a 40 MW plant started in 2007 and to be completed in 2009 in Brandis, Germany.
The company is currently building a 10 megawatt (MW) photovoltaic (PV) power plant for Sempra Generation near Boulder City, Nevada. Construction began in July; the plant is expected to be completed by the end of 2008.
In addition, First Solar has announced that the CPUC approved project terms of a 20 year power purchase agreement between First Solar and SCE for the sale of electricity generated by a PV power plant. First Solar plans to build the new plant in Blythe, CA. The PV power plant will be a minimum of 7.5 megawatts, with an option by First Solar to increase the size to 21 megawatts, and when completed will be the largest ground based PV power plant in California. First Solar expects to begin construction of the PV power plant in 2009.
Financial results for the third quarter ended September 27, 2008. Quarterly revenues were $348.7 million, up from $267.0 million in the second quarter of fiscal 2008 and up from $159.0 million in the third quarter of fiscal 2007.


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Every month or so, HSBC New Zealand employees get to enjoy the food, traditions and dress of a different culture without even stepping outside their office.
The bank’s 230 staff members identify with at least 40 different nationalities and speak more than 50 languages, and frequently interact with clients from a wide variety of countries, along with HSBC offices around the world.
This diversity is celebrated and encouraged thanks to EMBRACE, an employee resource group dedicated to building a culturally open and inclusive working environment. The initiative is sponsored by the HSBC Diversity and Inclusion committee and is made up of staff volunteers from different department and backgrounds.
EMBRACE has two main missions: to build awareness of different cultures including their perspectives, work and social etiquette; and educating staff on embracing inclusion and leveraging the benefits of a culturally diverse workplace, overcoming its challenges.
As Business Manager Phong Do puts it, “HSBC New Zealand is a team of people from various cultures and backgrounds, like a salad bowl with multiple types of vegetables. Like a good dressing that harmonises the different textures and tastes to make the salad complete, EMBRACE was founded to build an environment that bonds the diverse workforce, enables employees to be their true selves, to overcome the cultural barriers and deliver results as one team.”
EMBRACE delivers on its mission with fun, interactive and engaging activities designed to appeal to staff. This includes themed events centred around cultural celebrations such as Matariki, Eid and Rosh Hashanah. Attendees are invited to dress in the national dress of the featured culture, taste its food and take part in traditional activities.
Pot luck meals are another popular activity. Small groups of up to 10 are randomly picked from different areas of the business. Each employee brings a plate from their culture and has the opportunity to share their food and their stories with colleagues in the group.
“They provide an immersive experience where staff can live another culture in a few hours, can dress and eat and play and think like a local,” says Phong.
Other opportunities to learn about different cultures are promoted via Culture Wizard, an interactive tool developed by HSBC in collaboration with RW3, specialists in the intercultural training and e-learning industries. It provides information on a wide variety of countries and can be customised to suit each user’s specific requirements. EMBRACE organises quizzes for staff based on the contents of Culture Wizard to encourage employees to use it.
Senior leadership has shown its support via guidance and advice, along with funding for events. Senior leaders attend events and encourage their team to do the same.
Phong says EMBRACE has not only promoted cultural understanding within HSBC, it has improved staff engagement.
“For our people, an inclusive atmosphere makes them feel valued for their unique contribution and fosters mutual respect. It can also be professionally enriching – exposing our people to new skills and approaches to work. This, in turn, helps the organisation to attract and retain the best talent,” he says.
HSBC New Zealand’s Country Head of Commercial Banking and Diversity & Inclusion Executive Committee-sponsor Rob Roughan says, “The next stage of our EMBRACE journey is how we can better apply HSBC’s multicultural learnings and experience to the wider community in New Zealand, including our clients.”


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In a recent press release to the public and investors alike, EA confirmed a multi-channel partnership with Illumination entertainment, gaining exclusive rights to produce mobile games based on their content.
Who is Illumination Entertainment? They are the production house of wildly successful childrens movies such as Minions and the new Secret Life of Pets. Young millennial women looking for pixelated, 3D menstrual relief coupled with the latest Ben and Jerry’s are also a huge market share.
Will this be another money printer for EA? Well seeing as Children adore these movies. And all children have phones. And these phones often have mommy and daddy’s card on iTunes for in app purchases. I’d say yeah it will. Need I say more?


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Review: Naval Warfare (PC)
In the world of Naval Warfare, you are in control of the Emperean vessel captained by Captain Grey and manned by his loyal crew. In a steampunk-style world were two supreme powers come face-to-face in an unexpected war. Fueled by a mysterious plot, you struggle to survive against uneven odds to protect the world from the forces of evil. Taking on pirates, sea monsters and the enemy fleet, you must rely on you upgrades, allies, special weaponry and captain’s intuition to save the day.
All right, so I have to say first and foremost, this game isn’t bad, and honestly could be enjoyable… That is if it actually worked properly at all times. I was rather excited to play the game when I first saw the trailer, as it reminded me of Red Alert, at least by the visual appearance. It also looked to have a kind of Asteroids feel to it. While the story was all right and the characters seemed somewhat intriguing, the gameplay controls were a bit irritating at times. I also dealt with glitches and program problems after downloading it. So let me try and explain this experience, and maybe it will help in the developers in fixing the problems.
To start, let me give you an idea of what went on in trying to get the game to work. After downloading it, I had a problem of it even showing up on the computer screen, which I figured was maybe a driver problem. So, with that in mind, I made sure to update all my drivers and do restarts, uninstalling, reinstalling and all that jazz… but to no avail. Then, I attempted to peruse the interwebz to see if I could find someone else encountering the same issues, and yet again, no luck. Next, I went to the developer’s site and could find nothing on the game, only information on a new game that they had made. Then, I went to Steam’s site, which told me to do everything I had already done. So, at this point, I was rather frustrated, almost to the point of not wanting to do anything further and give up. That’s when I stumbled upon a way to actually bring the full game up instead of a black screen with sound. Which, to be frank, was just luck. To finally get the game up, I found out that I had to 1. Start the game to the black screen, 2. Ctrl-Alt-Delete to get to the task manager options in Windows 7, 3. Click Cancel, which I did by mistake the first time. This finally brought me to a visible starting menu page for Naval Warfare.
So, it was finally time to start playing the game. After going through the tutorials and getting the feels for the controls, I came to the actual start of missions, which went well for about five minutes. After that, the game would keep minimizing and I would have to do the task manager thing over and over again. So, of course I had a new puzzle to figure out. This took a bit before I really noticed what was going on. Come to find out that, while playing the game, my mouse wasn’t actually constrained by the game screen and I could still move it to my other monitor. Thus, while in the heat of battle, I would unintentionally click on the desktop of my other display and it would minimize. This of course made me look into my computer settings and see if the program was opening into a full screen mode, which it was. So this became a continued problem, to the point of rage at times, eventually dropping my interest in playing. Yet, I did continue, mostly because I was still interested in the story and where it would go to next.
My next issue was the continual lag in gameplay. This led me to double check system requirements just to be sure, all of which were above the standards. I have yet to figure out the exact reason for this (any ideas would be great). I don’t believe it was because there was too much stuff going on, because it would happen when there was nothing but the ship and water. This led to a rather irritating time with controls. It would get so bad at times that my ship looked like it was moving in stop motion, which would end up getting me shot because I couldn’t dodge shots in time. Since this game was originally made to use a controller rather than a keyboard, I would strongly recommend one if you do buy it for PC. I believe this because it felt like the flow of the movements didn’t live up to what I think it’s capable of with just the arrow keys.
So, now that I’ve done my ranting, let’s look at some things that I did like when playing Naval Warfare. First of all, I really did like the graphics. They were very vibrant and had quite a bit of detail. As stated before, it kind of reminded me of playing Red Alert visually, which was stimulating and, when working, did make it enjoyable. I also liked the variety of different vessels that you come up against while playing the game. The strategies employed in the gameplay made you really put some thought into what weapons or boats you needed to use to pass a level.
Interchangeable upgrades were also a really good idea. I find it irritating when you are limited to only upgrading a vessel once, like they just welded it and never heard of bolts to attach things. As for the story, I found it intriguing enough to go through the hassles of bugs and glitches. Though it isn’t a super in-depth story, it is still rather fun to go through. The addition of the voice actors was nice, and for the most part the talent was pretty good. But sometimes, the vocal expression may have been a little misplaced. In addition, I did like the musical arrangement, which was better than what I was expecting before playing the game. Throughout the game, there was never an issue with the sound. It always seemed to be at the right pace, although at times the animations would have to catch up with the words, something that is again probably due to the programming.
Overall, I can see where this game has some good potential to be fun and entertaining. Unfortunately, like with most things, if it’s not working properly, then most of the enjoyment gets sucked right out of it. So, although the graphics were nice and the story seemed pretty decent, I still found myself rage-quitting most of the time because of the bugs. As it stands right now, I would recommend buying the game on XBLA rather than Steam, at least until they fix the bugs. Additionally, I would also reinforce getting a controller to make movement smoother. In the end, I have to rate it the following:
Final Rating: 6/10
CBR Break Down:
Console Played On: PC (Steam)
Approximate Time to Completion: 7+ maybe, hard to say with all the program problems.
Gamer Score Earned: N/A
Price Bought at: N/A – Review copy furnished by Game Distillery s.r.o.
Current Price: $9.99 (PC Download Copy from Steam)
Recommend Purchase Price: If it all worked properly, then I would agree with the price.