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Former President Olusegun Obasanjo has entreated state governors to elevate the bar in their overall performance in order to provide new lease of existence to the people.
Obasanjo made the call on Friday in Enugu, while he called on Gov. Ifeanyi Ugwuanyi of Enugu nation, after attending the burial of Ebonyi governor’s mother. The previous president stated that correct governance would raise the monetary growth of the nation. He, but, recommended Ugwuanyi on his good works inside the country and advised him to do more as posterity might choose him. “From the reviews i am getting, you are doing well. If out of the 36 states of the usa, you could get one that is doing well, it is going to be encouraging to continue to paintings on others to do properly. “by the time you can rise up to 50 per cent of the states doing properly, it method the us of a could be higher. So, maintain it up,” Obasanjo stated. Responding, Ugwuanyi thanked the former president for his go to and promised to tap from his wealth of enjoy. “we’re, certainly, very grateful. We will maintain to gain from your wealth of enjoy in order that we will maintain to serve our humans better,” Ugwuanyi said.


Residents Oppose Plan For 100 New Flats To Be Built On Industrial Site
- Stephanie Newton
- On July 7, 2017
Plan to build 100 flats on an industrial site in Hove have been opposed by over 200 residents.
The Crowborough based site, Cross Stone Urban Regeneration, was hoping to conclude their four year plan of redeveloping the site on School Road, Hove. However, locals aren’t happy with the proposed £10m scheme.
Locals have voiced their concerns about the height of the potential flats as well as the loss of jobs at businesses that will be forced to move and a potential loss of community facilities.
Despite this, the council seem happy with the plans claiming it will add a much needed refresh to the ageing complex of buildings.
The proposed plans would see 104 1, 2 and 3 bedroom flats being built as well as an office space in blocks three or four storeys high.
Unfortunately for the developers, there have also been some issues raised regarding affordable housing, with people questioning why the three bed flats won’t be made affordable and worrying about the impact on social housing.
There will also be a car park including 89 car parking spaces as well as room for bikes and other vehicles.


Since assuming office, President Obama has garnered his fair share of high-profile critics. But few have been as omnipresent and implacable as John Bolton. From his near constant appearances on Fox News and HBO’s “Real Time with Bill Maher” to his steady stream of op-eds in the Wall Street Journal and the New York Daily News, the 61-year-old former Ambassador to the United Nations and Under Secretary of State for Arms Control under President George W. Bush has been relentless in his critiques of President Obama’s agenda, especially in the realm of foreign policy.
In his office at the American Enterprise Institute, which is situated directly next to former Vice President Dick Cheney’s office, Bolton was far from reserved while talking to The Daily Caller about what he finds so alarming in President Obama’s foreign and domestic policies, how history will view the last Bush administration, and the possibility of a 2012 run for president.
“I’d call him the first post-American president and by that I mean – certainly in contemporary times – his view of America and its role in the world is different from the line of presidents since Franklin Roosevelt,” Bolton explained, when asked exactly why he finds the president’s foreign policy so offensive. “He doesn’t see himself effectively as a real advocate for America’s interest. He doesn’t see the world as a particularly challenging place. And, frankly, I just don’t think he cares that much about foreign policy.”
Asked if he gives any credit at all to the president for increasing drone attacks against terrorists in Pakistan and elsewhere, and tripling troop levels in Afghanistan – both moves that have upset his left flank – Bolton said they were moves the president was forced to take.
“Well, certainly he has done things that have been unexpected in Afghanistan and certain aspects of the War on Terrorism. I think those are steps he has taken because it has been impossible – even for him – to avoid taking them,” Bolton proffered. “For example, much of what he has done in terms of interrogation or Guantanamo Bay or aspects of the War on Terrorism are things that are driven either by the imperative of defending executive branch prerogatives under the Constitution or because he has come to realize that the Bush administration looked at a lot of alternatives and couldn’t find any. So it is not that he has done these things happily or willingly.”
Bolton has been unabashed in his view that military action will be necessary to stop Iranian nuclear proliferation. When asked whether he thinks that the president would ever order such strikes, Bolton said he couldn’t imagine it.
“I don’t see it. I just kind of think it is contrary to his ideological DNA. I’d love to be proven wrong and the future will tell. But I don’t see it,” he said.
One area Bolton has been particularly critical of the president’s foreign policy is in the president’s handling of the U.S-Israel relationship. He told TheDC that he thinks the president’s push for a peace process will not only not lead to peace, but will ultimately make an unstable region even more so.


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Britain is setting up a new tax task force to scrutinise the financial affairs of the nation’s wealthiest 500,000 people.
The new HM Revenue & Customs’ affluent unit will look at the tax affairs of everyone with a net wealth of £1 million or more.
The move is part of the government’s quest to squeeze an extra £4 billion from taxpayers who fail to properly declare their income and assets, said Chief Secretary to the Treasury Danny Alexander.
The government’s aim is to claw back an additional £7 billion tax a year by 2015, by investing £900 million in extra staff and technology.
Alexander is already celebrating the affluent unit’s success in reclaiming £44 million in lost tax in the past 12 months.
Contractors under scrutiny
He also confirmed that HMRC task forces will ensure contractors working in the public sector are not allowed to manage their tax to pay less with a corporate set up.
Alexander revealed the government is working on a strategy to stop companies with tax management strategies from winning public tenders and accepting taxpayer’s money. He promised further details would be released later in the year.
“Steps are also being taken to ensure that public sector workers are no longer paid in a way that potentially enables them to pay too little tax,” he said.
“There is currently nothing to prevent the small minority of companies who do not adhere to the rules from winning government contracts. I have asked HMRC and the Cabinet Office to set out a workable solution to this problem.”
Overseas tax pledge
Overseas tax management schemes are also to come under attack by doubling the task force tracking down income and assets in Liechtenstein intending to triple the tax take, explained Alexander.
“The Liechtenstein Disclosure facility offers a time limited opportunity to those with unpaid tax linked to investments or assets in Liechtenstein to settle their tax liability with the UK. The scheme had been intended to raise £1 billion but the government expects that by enlarging its work force, it can now raise £3 billion,” he said.
“The government will find those hiding their assets offshore and will ensure that they pay their fair share. The vast majority pay their taxes completely properly, but a small minority of whom are trying to get away with not paying what is due.”

domain: news


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However some of your comes from this study reinforce all of our current education and comprehension of afterwards existence dating, however they include expected breadth from insights to the private and you will cultural levels of the process of remarriage to possess more mature people
The fresh new program that might appear, upcoming, about stories from middle-category ladies in it cohort, born in the earlier in order to mid twentieth century, would-be a little distinct from an effective transgressive narrative envisioned because of the a good more youthful cohort. It’s a story one discreetly offers and fits the standard towards the imaginative, enabling new retention out of securely-held thinking on ladies roles, and you may on e go out redefining the probabilities to possess sexual satisfaction and you can relationship. It is through the voices of females like these that usually arise a viable solution, for them, towards learn story into the later on lifetime matchmaking.
Within data you Klik hier will find searched afterwards life relationship as a consequence of blogs and you will process analyses from ladies narratives of their earlier in the day dating, its single life, the development of another matchmaking, and you can remarriage. These ladies’ stories increase all of our comprehension of both mutual and you may customized areas of relationships creation and remarriage inside later on existence. The outcome provide understanding of the whole process of remarriage and exactly how elderly female choose from readily available social narratives in the love and you can relationship if you’re fighting new twice jeopardy found during these social messages one to inform them you to definitely love, love, gender, and you may a good remarriage that involves this type of circumstances are meant for this new younger. The significance of the fresh findings resides in what this type of females have demostrated within visits while they defy the brand new assumption stored by the community, and also themselves, you to the elderly is actually asexual. Some of the people actually took part in this new interviews because they desired to relay so it message. It had been a discovery they had generated, in addition they planned to dismiss that it extensively-kept trust.
Another significant looking using this research focuses primarily on these types of ladies’ ability so you’re able to negotiate an enthusiastic interdependence within this new relationship. Most got centered a feeling of freedom whenever single by which they certainly were most proud. Lookup to your widowhood and you can dating into the after existence has unearthed that one of the major factors women do not desire to remarry are deficiencies in want to stop which versatility and independence he’s got worked so very hard to establish. Such women reveal the way they did to utilize anybody brand new and you will show the lives with our people whilst not sacrificing the sense of self due to the fact separate. It interdependence is not recognized as a tension otherwise battle, however, because the an equilibrium ranging from what the personal desires whenever you are getting inside a sexual relationship with another person.
Connidis (2006) reminds all of us one “the fresh accumulated exposure to an existence sets a later part of the-lives relationship towards a different sort of footing away from a wedding prior to during the life” (p. 134). The ladies who had been questioned because of it study exemplify this statement in how they went on choosing from the remarriage, what they were hoping to find in the a married relationship, and how they spotted themselves since the women. The decision to remarry as well as the timing between initiation of dating and remarriage portrays the process of dating creation and you will invention is going to be each other similar to and you can extremely not the same as prior to into the the life course. New event of experiencing come hitched, elevating children, and being inside the after lifetime, offered these females a specific framework inside that they created their decision so you can remarry. Such as this, the previous matchmaking and you can event considering a background with which to help you compare and you will judge what they performed and did not wanted during the a wedding, while the understanding and also make a choice that they believed is best for her or him so far within existence.

domain: psychology


Villanova at butler, 10 a.m., cbs. The equalizer “it takes a village” mccall investigates a community activist’s staged suicide and uncovers a connection between his murder and his protests over local real estate development.
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I’ve talked with a lot of pilots over the years, both men and women who fly for major carriers like American and British Airways. For the most part, they are very nice people but when they tell us to do something, we have to obey because a pilot’s word is law on a plane. The good news is, their biggest concern is for our safety. In that spirit, here’s a list things passengers should never do.
Don’t Roam the Cabin
Not long ago, a news report featured a young man who roamed his British Airways plane while repeatedly asking to get off. Where was the aircraft? Over the Atlantic Ocean! The lad ultimately got his wish when the Florida-bound flight was diverted to Boston and law enforcement officials escorted him off the plane. By the way, some passengers have been known to take it a step further, physically attempting to open plane doors in mid-flight. This good news is, this can’t be done.
Don’t Mess with the Crew
Passengers who mess with flight attendants and other members of airline crews generally regret it. They get kicked off flights, arrested and even jailed. Some examples:
- A passenger who allegedly made sexist comments to an Alaskan Airlines flight attendant during a safety demo was reportedly ordered off the flight.
- Another passenger on Hawaiian Airlines wound up in a Honolulu courtroom after being accused of biting a flight attendant (he pleaded guilty).
- A traveler on an EasyJet plane also reportedly came to the attention of law enforcement after he was accused of – how to put this? – mistaking fellow passengers for the lavatory.
Don’t Overindulge in Alcohol (or Similar Substances)
Too many cocktails rarely bring out the best in passengers. This was certainly true for a fellow on a recent Frontier flight who was accused of being intoxicated to the point that he grabbed female passengers before allegedly urinating on the seat in front of him. Then there was the Ryanair passenger a couple of years back who supposedly drank from a whiskey-filled shampoo bottle while shouting expletives and threatening nearby passengers. Both men were ultimately taken away in handcuffs by law enforcement officials which is a terrible way to start a vacation.
Don’t Make Me Leave the Cockpit and Come After You
That may have been the thought going through the head of one American Airlines pilot who was overheard shouting, “You don’t put your hands on my flight attendant!” Shortly afterward, the pilot tackled the offending passenger. The incident wound up on YouTube and the passenger wound up in court.
Final thought: Every pilot I talked to said they truly enjoy 99.99% of their passengers and consider it a privilege to fly us. The remaining .01% probably didn’t follow these basic, common sense rules.


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SAMMAMISH, Washington — A Catholic high school vice principal fired last month for marrying his same-sex partner says in a video interview posted on YouTube Saturday that a school official told him he could keep his job – if he divorced his husband.
Mark Zmuda, 38, also said in the video interview that he was, in fact, fired. Mike Patterson, a lawyer for Eastside Catholic High School, has repeatedly denied the allegation, saying that Zmuda resigned voluntarily.
Zmuda’s departure last month was not taken well by students, who protested in the hundreds for his return. Students at other area schools, both parochial and public, joined their protests.
In the video, Zmuda and his husband, Dana Jergens, sit down at Good Samaritan Episcopal Church in Sammamish with an Eastside Catholic student, Catrina Crittenden, who conducts a 16-minute interview with the couple. Crittenden asks Zmuda to clarify the circumstances of his departure.
“To set the record straight, I was terminated,” Zmuda said. “When I was told, I asked why I was being terminated and they said because I violated Catholic teaching.”
Zmuda said he was told his termination was not due to a breach of contract or his job performance, but “because I was married to a man, and violated Catholic teaching.”
He goes on in the interview to say, however, that the school’s president, Sister Mary Tracy, told him that he could keep his job if he divorced Jergens, whom he married in July.
“I was a little shocked, because apparently the fact that I have a same-sex partner and having a same-sex marriage, they are against that,” Zmuda said. “But I also thought another teaching they were against was also divorce. So I’m a little shocked that was even on the table to have me keep my job.”
The Seattle Times reports that Patterson said Zmuda's statement about the divorce was not true. The lawyer did acknowledge, however, that he was not present for that conversation with Tracy and that the subject of divorce did come up.
The lawyer said Tracy raised the idea of divorce only as a hypothetical question, along the lines of “would you consider a divorce ... I don’t even know if that would work.” Patterson said the nun made the statement without legal counsel.
Zmuda said divorce is not something he would consider, the newspaper reported.
Crittenden asks the couple some background details about their lives, including their faith. Zmuda, who is Catholic, said he does not agree with the Catholic Church’s stance on homosexuality.
“People, I don’t think, choose to be straight or gay,” he said. “Instead, they discover that they are one or the other.”
Zmuda said his Catholic faith is a part of his daily life and that he uses prayer to talk to God.
“And I pray every day,” Zmuda said.
Zmuda said his faith has taught him to have dignity, be kind to others and show people respect.
The couple also talked about their summer wedding, which they said was a happy, fun affair without tension or upset among family and friends.
They were most worried, Jergens said, about something that all couples worry about – their parents meeting for the first time.
“With it being a same-sex wedding, there was worry there,” Jergens said. “But those completely washed away very quickly.”
Zmuda said he has been overwhelmed by the support he and Jergens have received, particularly the support of his students at Eastside Catholic. Though the Virginia Tech graduate has been an educator for 14 years, he had only been at the school for a year and a half.
Aside from acting as the school's vice principal, Zmuda also served as its swimming coach.
The majority of Eastside Catholic’s faculty members were also supportive when they learned Dec. 19 that Zmuda had been terminated. Many tried to find ways for him to stay.
“Has the Pope heard about this?” one faculty member asked, according to Zmuda.
Pope Francis has made unprecedented statements over the past several months in which he reaches out to the LGBT community.
“If someone is gay and he searches for the Lord and has good will, who am I to judge?” Francis said to reporters this past summer.
The Seattle Times reports that Eastside Catholic students held a rally outside the Seattle Archdiocese’s offices on Saturday in support of Zmuda. More events are planned, including a nationwide “Z Day” on Jan. 31, during which students are asking people across the country to wear orange, one of Eastside’s school colors.
“We will continue to write letters, lobby Church officials, and use any other means at our disposal to respectfully work toward our ultimate goal of changing the discriminatory attitudes regarding homosexuality in the Church,” the local students said in a statement.

domain: sociology


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domain: food


ORLANDO, Fla. – The family of Miya Marcano, the Orange County woman who disappeared from her UCF-area apartment in September 2021 and was later found dead, is suing the Orange County Sheriff’s Office, as well as the two deputies initially handling her missing person case.
The 19-year-old, a South Florida native, was a graduate of Flanagan High School in Pembroke Pines.
The lawsuit, obtained by Local 10 Orlando news partner WKMG, said the sheriff’s office failed “miserably” to properly train and supervise its deputies in how to handle a case like Marcano’s. It also accused the sheriff’s office and its two employees — Deputy Samir Paulino and Cpl. Kenneth Dale, Paulino’s supervisor — of violating Marcano’s civil rights.
Marcano’s disappearance was reported on Sept. 24, 2021, when Paulino went to the Arden Villas apartment complex to perform a well-being check. Marcano’s mother had requested the check because Marcano was supposed to get on a flight that night and wasn’t responding to her phone.
A report shows Marcano’s door to her bedroom had been blocked with a piece of furniture, her bed wasn’t made, there was blood on her pillow and broken and bent jewelry on the floor.
But Dale said Paulino did not tell him most of that information during an agency investigation into the case. Because of this, Marcano was considered a “voluntary missing person” instead of a “missing endangered person.” The case was not escalated to the Criminal Investigations Division.
The lawsuit also claims Paulino did not take the family or the apartment complex security guard seriously when they asked about fingerprint evidence or provided details about concerns that Armando Caballero, a maintenance worker at the complex, could be involved in her disappearance.
At one point, the lawsuit claims Paulino told the apartment complex security guard that the case was “not a priority” unless she was elderly or disabled.
Caballero was found dead from suicide on Sept. 27, 2021. Marcano’s body was discovered on Oct. 2, 2021. It’s now believed Caballero killed Marcano.
Paulino received a 150-hour unpaid suspension as discipline for the investigation failures, and Dale received a 10-hour unpaid suspension. However, the family found that discipline insufficient.
“This failure to discipline its employees in a relevant respect reflects a deliberate indifference to the rights of its inhabitants and is actionable under 42 U.S.C. § 1983. Despite Paulino’s willful neglect, OCSO continues to employ him with a simple slap to the wrist,” the lawsuit states.
The family also claimed the sheriff’s office has not made any policy changes in the wake of the case, even though Sheriff John Mina said last year that they were in the process of doing so.
“We believe that the Orange County sheriff’s deputies that came out to the scene — had they been properly trained, had they had any sense of urgency, this could have happened a whole lot differently,” said Daryl Washington, the attorney for Marcano’s family.
Washington told News 6 that he and the family want to hold the sheriff and mayor accountable.
“You’re not necessarily filing a lawsuit against the mayor, but we are holding the mayor and other policymakers of Orange County accountable for the lack of training,” he said.
The family has also filed a wrongful death lawsuit against the apartment complex’s parent company for its own security failings.
In the wake of the Marcano case, Florida lawmakers passed a bill last year aimed at increasing physical safety for renters.


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Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells. Antigenic relations of blood group antigens as suggested by tests with lectins. The signal generated with this method results from the precipitation of silver onto nanogold particles bound to streptavidin used to detect biotinylated DNA. Identification of novel viral receptors with cell line expressing viral receptor-binding protein. The study may help to increase understanding of the medicine shoppe generic viagra functions of molluscan PVF.
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Moreover, as an effective antagonist of IL-1 beta, the actions of CTS may involve disruption/regulation of signal transduction cascade of IL-1 beta upstream of mRNA transcription. Intraperitoneal administration of cycloheximide (1 mg/kg body weight) to rats immediately after an artificial deciduoma induction inhibits the development of decidual tissue. A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity, PT-9K/129G, is an viagra pills for sale effective mucosal adjuvant for intranasally delivered proteins. Treosulfan based conditioning for autologous and allogeneic hematopoietic stem cell transplantation.
Migration history, access to HIV-related care at diagnosis, current and pre-HIV sociodemographic characteristics, and current health status. Magnetic resonance imaging is the imaging method of choice in most diseases of the spinal canal and cord. By day 18, CHr of the control group declined into the quadrant of the diagnostic plot characteristic of functional iron deficiency and anemia of chronic disease. We have identified a novel essential nucleolar factor required for the synthesis of 5.8S and 25S rRNAs termed Npa1p. Measles-specific salivary IgA antibodies were maui generic viagra detected in 15-month old children 2-3 weeks after immunization.
Plasma prolactin levels in normal children from birth to adolescence Postoperative adhesions: an underappreciated complication of cesarean deliveries. Therefore, OPN is not merely associated with cancer, but rather it plays a multi-faceted functional role via complex molecular cross-talk with other factors. Comparison of clinical and maurices generic viagra histological diagnosis in kidney post-transplantation period
A painless and stable limb is achievable, and the use viagra pills generic of this technique can be further refined. Professionalism 1: the conduct, aims, or qualities that characterize or mark a profession or a professional person. The evaluation comprised workload analysis, student evaluation, student interviews and student reflections. For these complexes several low-lying vibrational states are computed, and their binding energies and radial/angular probability density distributions are obtained. Medical services provided to 2,394 patients at methadone programs in three states. In contrast, an optimum diet during gestation and lactation rendered the animal less susceptible to the depressing effects of nutritional deficiency during adult life.
The latter remained viagra pills lowest price in aquatic area almost throughout the period of behavioral observation. Relationship of secretion of GnRH in vitro to changes in pituitary concentrations of LH and FSH and serum concentrations of LH during lactation in sows. Factors associated with use of emergency medical service for acute myocardial infarction in Beijing A total of 131 Aeromonas isolates were obtained and identified as follows: A. The study used a mixed-method design with a quasi-experimental approach and focus group interviews. The aim of this study was to prospectively compare the clinical results of single- and double-bundle ACL reconstruction.

domain: medical


This is a 3 minute inspirational documentary about Professional photographer Tendai Pottinger.
We follow Tendai in a day of a fashion photography shoot of a young model as Tendai explains his passions for Photography.
Starring: Tendai Pottinger
Director: Rikki Chandler - Bachelor Eye
Assistant Director: Marcus Springer - Saviour Mediatricks
Cameraman: Jerome Elliott
Editor: Jasbir Nangla
Lighting: Marcus Springer
Sound: Jasbir Nangla
Music by: Crushed Stars


text:
|Drug class||Orexin antagonist|
|Metabolism||Liver (major: CYP3A4, minor: CYP3A5)|
|Elimination half-life||17–19 hours or 55 hours|
|Chemical and physical data|
|Molar mass||410.425 g·mol−1|
|3D model (JSmol)|
Lemborexant, sold under the brand name Dayvigo, is an orexin antagonist medication which is used in the treatment of insomnia. It is indicated specifically for the treatment of insomnia characterized by difficulties with sleep onset and/or maintenance in adults. The medication is taken by mouth.
Side effects of lemborexant include somnolence, fatigue, headache, and abnormal dreams. The medication is a dual orexin receptor antagonist (DORA). It acts as a selective dual antagonist of the orexin receptors OX1 and OX2. Lemborexant has a long elimination half-life of 17 to 55 hours and a time to peak of about 1 to 3 hours. It is not a benzodiazepine or Z-drug and does not interact with GABA receptors, instead having a distinct mechanism of action.
Lemborexant was approved for medical use in the United States in December 2019. It is a schedule IV controlled substance in the United States and may have a low potential for misuse. Besides lemborexant, other orexin receptor antagonists including suvorexant and daridorexant have also been introduced.
Lemborexant is used in the treatment of insomnia in adults. Compared to benzodiazepines, there is a low risk of developing tolerance and dependence. Memory and attention are not affected the next morning when taking lemborexant.
Lemborexant is available in the form of 5 and 10 mg oral film-coated tablets.
Side effects of lemborexant include somnolence or fatigue (combined preferred terms of somnolence, lethargy, fatigue, and sluggishness) (6.9% at 5 mg and 9.6% at 10 mg vs. 1.3% for placebo), headache (5.9% at 5 mg and 4.5% at 10 mg vs. 3.4% for placebo), and nightmares or abnormal dreams (0.9% at 5 mg and 2.2% at 10 mg vs. 0.9% for placebo). Less common side effects include sleep paralysis (1.3% at 5 mg and 1.6% at 10 mg vs. 0% for placebo) and hypnagogic hallucinations (0.1% at 5 mg and 0.7% at 10 mg vs. 0% for placebo).
Lemborexant at doses of 10, 20, and 30 mg produces drug-liking responses similar to those of zolpidem (30 mg) and suvorexant (40 mg) in recreational sedative drug users. It is a controlled substance in the United States and is considered to have a low misuse potential.
Lemborexant is a dual antagonist of the orexin OX1 and OX2 receptors. It associates and dissociates from the orexin receptors more rapidly than certain other orexin receptor antagonists, such as suvorexant, and this may cause it to have a shorter duration of action.
The bioavailability of lemborexant is good and is at least 87%. The time to peak levels of lemborexant is 1 to 3 hours. A high-fat and high-calorie meal has been found to delay the time to peak levels by 2 hours. Its plasma protein binding in vitro is 94%. Lemborexant is metabolized primarily by CYP3A4 and to a lesser extent by CYP3A5. The "effective" half-life of lemborexant is 17 to 19 hours while its terminal elimination half-life is 55 hours. The medication is excreted in feces (57%) and to a lesser extent urine (29%).
Although lemborexant has a longer terminal elimination half-life than suvorexant, it appears to be more rapidly cleared than suvorexant in the earlier phases of elimination. In addition, lemborexant dissociates from the orexin receptors more rapidly than does suvorexant. These differences may allow for comparatively reduced next-day effects such as daytime somnolence with lemborexant.
In June 2016, Eisai initiated Phase III clinical trials in the United States, France, Germany, Italy, Japan, Poland, Spain and the UK.
In December 2019, lemborexant was approved for use in the United States based on results from the SUNRISE 1 and SUNRISE 2 Phase III clinical trials.
Lemborexant is the generic name of the drug and its INN while E-2006 was its developmental code name. Lemborexant is sold under the brand name Dayvigo.
Lemborexant is marketed in the United States, Canada, Australia, and Japan. It is not approved by the European Medicines Agency (EMA) for use in the European Union or by the Medicines and Healthcare products Regulatory Agency (MHRA) in the United Kingdom.
Lemborexant is under development for the treatment of circadian rhythm sleep disorders, sleep apnea, and chronic obstructive pulmonary disease. As of February 2022, it is in phase 2 clinical trials for circadian rhythm sleep disorders and phase 1 trials for sleep apnea and chronic obstructive pulmonary disease.


Visit Us at RotorTech 2022 in Brisbane, Australia
Wednesday, April 6, 2022
Onboard Systems will be exhibiting at the RotorTech 2022 Helicopter and Unmanned Flight Exposition, to be hosted at Brisbane’s Royal International Convention Centre (RICC) on June 21st-23rd. If you are attending the show in person, you can visit us at Booth 1D3 to meet with our sales team to get answers to any questions you may have about Onboard's products and services.
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RotorTech is the premier industry event for the Helicopter/Rotary Wing and RPAS/UAV/eVTOL community in Australia, New Zealand and the Indo-Asia-Pacific region. This exhibition will provide a vital interface between industry, regulators and government, including: Operations and safety presentations Industry conferences Industry exposition showcasing the products and services of helicopter and unmanned flight related companies. In addition, RotorTech will host conferences by the Australian Helicopter Industry Association (AHIA) and Australian Association for Uncrewed Systems (AAUS) and feature presentations by key rotary and unmanned systems industry experts from Australia and the Indo-Asia-Pacific region.
Access to the exhibition and conference program is free of charge to all accredited RotorTech visitors, which include those with a professional, governmental agency, business, academic, scientific, operational or response involvement in rotary wing and unmanned systems and related industry sectors. Click here for registration information.
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text:
All good things must come to an end.
Bridget Kelly has parted was with her label Roc Nation. The mills were churning that there was trouble in music paradise between the two and she told confirmed the rumors to Rap-Up.
“Honestly we needed to part ways. You outgrow situations sometimes,” she told the site at the ASCAP Rhythm & Soul Music Awards yesterday (June 26). “I still feel their love. They’re still people I confide in and people that I have a really strong personal relationship with, so in order to keep that intact we needed to just go our separate ways.”
After six years of being under Jay Z’s label, BK is a free agent.”It’s liberating to know that I can just go in with whoever and put anything out that I want to and say what I want to.”
Earlier this month she released two songs, “I Won’t Cry” and “Almost More,” both will be off her long overdue debut album due out September.
Press play to hear her full interview

domain: artistic


text:
My mom brings a few of her good friends to my parent's cabin for a week every summer. I've never gone, so I don't know what happens, but they always like to say "What Happens at the Cabin, Stays at the Cabin" when they get home. (They're all middle school teachers, I don't think they do anything very incriminating haha). Mom has always wanted a sign with this phrase to hang in the cabin, but none of us were willing to spend money on one (can you tell I come from a frugal family?) So, for her birthday this year, I made her one!
I found this board in our basement (leftover from the previous owner).
I painted it a beige-y color. I did everything by hand, including the wavy boarder and the letters. (I am not lucky enough to have a cutting machine...yet! My Silhouette is in the mail..sooooo excited, thank you Hubby!) Anywho, I had to paint by hand and I think it turned out pretty nice if I do say so myself!
I found these little metal dealy-bobs at a craftstore in Northern Wisconsin (where the cabin is located). They were perfect and really added to the sign. I love how it turned out!
My parents are heading up there this weekend to get everything open for the summer, I'll have to get a picture of it in it's new home.
I linked up to:
Sumo's Sweet Stuff's Market Yourself Monday


text:
Recipe: Bette’s Sensational Strawberry Muffins
BETTE’S SENSATIONAL STRAWBERRY MUFFINS
Servings: 1 dozen
11/2 cups strawberries, coarsely chopped
3/4 cup sugar
13/4 cups flour
1/2 teaspoon baking soda
1/4 teaspoon ground nutmeg
1/4 teaspoon salt
2 eggs, beaten
1/4 cup unsalted butter, melted
1 teaspoon vanilla extract
Preheat the oven to 425 degrees and grease muffin cups or line with paper liners. In a small bowl, combine the strawberries and 1/2 cup of the sugar and set aside for 1 hour.
Drain, reserving the liquid, and place in a separate bowl. In a medium-sized bowl, combine flour, baking soda, nutmeg and salt. In another bowl, mix the eggs, butter, vanilla, remaining 1/4 cup sugar and strawberry liquid. Stir until well combined and fold in the dry ingredients until just moistened, taking care not to over mix. Fold in the strawberries.
Spoon batter into muffin cups and bake for approximately 20 minutes or until a toothpick inserted in muffin centers comes out clean. Serve warm or cool.
“Produce Pete’’ Napolitano


text: Red Robin has decent food, but I have consistently gotten bad service. I rarely ever get a refill on my drink without having to hunt the waitress down to ask for one. Also, they are terribly slow (even if they aren't busy) - you have to wait for your food for a very long time. The other thing that I hate (those of you with kids will understand) is that they always bring the adult's food out first and then say that they are waiting on the kids food. Then you are sitting there with your kid upset because they are hungry and everybody else has food but them.


text:
Musician Sweetlemondae: ‘I don’t have any regrets. Good or bad, everything happens for a reason’
The Galway artist was named as one of ten artists to look out for this year on RTÉ 2FM’s Rising list
Sweetlemondae was just 15 when she began releasing music on Soundcloud and YouTube, drawing inspiration from female artists such as Little Simz, Coi Leray, IAMDDB and 070 Shake.
But it was fashion and not music that was her first love. “I’ve always been interested in fashion, so for a while when I was younger I wanted to work in the fashion industry. I love the freedom of self-expression, clothes can give people,” the Galway artist ...


text:
Long before the University of Oklahoma was established, the land on which the University now resides was the traditional home of the “Hasinais” Caddo Nation and “Kirikirʔi:s” Wichita & Affiliated Tribes.
We acknowledge this territory once also served as a hunting ground, trade exchange point, and migration route for the Apache, Comanche, Kiowa and Osage nations.
Today, 39 tribal nations dwell in the state of Oklahoma as a result of settler and colonial policies that were designed to assimilate Native people.
The University of Oklahoma recognizes the historical connection our university has with its indigenous community. We acknowledge, honor and respect the diverse Indigenous peoples connected to this land. We fully recognize, support and advocate for the sovereign rights of all of Oklahoma’s 39 tribal nations. This acknowledgement is aligned with our university’s core value of creating a diverse and inclusive community. It is an institutional responsibility to recognize and acknowledge the people, culture and history that make up our entire OU Community.
Welcome to the OU Hydrogeology research group site! The Hydrogeology area of study began in Fall 2018 upon the arrival of Dr. Dee whom brings a wealth of research and applied experience to the School of Geosciences at the University of Oklahoma. Within this website, you will find information regarding Dr. Dee’s current and planned research, current students (both undergraduate and graduate), publications, and the Aqueous Geochemistry Laboratory. This site will be periodically updated so please check back often.

domain: geography


text:
(Saturday, December 21st)
Final Score: (18) Kansas 86, Georgetown 64
Lawrence, KS (SportsNetwork.com) - Tarik Black and Joel Embiid each scored 17 points and combined for 14 rebounds as the No. 18 Kansas Jayhawks easily cruised past the Georgetown Hoyas, 86-64, on Saturday afternoon. Kansas (8-3) returned to Allen Fieldhouse for the first time since Nov. 22 and the friendly confines suited the Jayhawks just fine, as they connected on 54.3 percent of their shots to win going away. Andrew Wiggins added 12 points and Naadir Tharpe chipped in 10 for the Jayhawks, winners of two straight after setbacks at Colorado and Florida. Markel Starks netted 19 points to pace the Hoyas (7-3), who had their six-game winning streak snapped.
Final Score: (19) Kentucky 93, Belmont 80
Lexington, KY (SportsNetwork.com) - Julius Randle had 29 points and 10 rebounds in the 19th-ranked Kentucky Wildcats' 93-80 victory over the Belmont Bruins on Saturday. Randle missed just two of his 10 shots from the field and went 13-of-19 from the foul line for the Wildcats (9-3), who bounced back from a loss to North Carolina last Saturday. Aaron Harrison tallied 23 points, seven assists and six rebounds for Kentucky, which went 26-of-36 from the charity stripe. Willie Cauley-Stein donated 16 points and seven boards. Craig Bradshaw and Drew Windler ended with 22 and 21 points, respectively, for the Bruins (8-5), who have lost three in a row.
12/21 14:44:14 ET


Every year brings on a new set of challenges for harvest and grain management; in the past five years... Read more.
Farmers from the biggest U.S. corn-growing states have sued Syngenta AG over sales of genetically... Read more.
Purdue researchers have identified a set of genes that can be used to naturally boost the provitamin... Read more.
With a chill in the air that feels all too much like autumn is upon us already, it's a great reminder... Read more.
The 2014 corn silage harvest season is in full swing in the North Country. Fields planted in May are... Read more.
Syngenta announced that Jim Cuddeback, a corn and soybean grower from Washington, Iowa, is the grand... Read more.
Global seed technology giant Monsanto said on Monday it has launched a global center in Mexico... Read more.
In its latest Grain Stocks report, the USDA reported 1.24 billion bushels of old crop corn stocks... Read more.
Eliminating weed seeds before they can establish new plants is a practical and effective means of... Read more.
Cheminova, Inc. announced the launch of Harrow herbicide, a selective herbicide for use in field... Read more.
SDSU weed science team confirms the finding of Palmer amaranth (Amaranthus palmeri) in South Dakota.... Read more.
Energy security, environmental benefits and rural economic development are among the primary arguments in support... Read more.
- $3.6M to assist California farmers with drought
- Syngenta lawsuit against Bunge over GMO corn revived on appeal
- Crop markets were strong Tuesday night
- Five things to know about fall herbicide treatments
- U.S. urges Japan to be 'bold' in Pacific trade pact talks
- Program aims to increase number of grads working in agronomy
- How much corn can the ethanol industry use?
- Economist: Taxing P could reduce risk of algal blooms
- Commentary: Government wants farmers to quit farming
- Source shows half of GMO research is independent
- Ag markets made a generally mixed showing Thursday night
- What is the relationship between maturity group, yield?


27-year-old artist from Italy Sven Sahsalber recently arranged in the gallery “Tokyo palace” in Paris unusual presentation. He brought with him a suburban farm haystack; upload it directly to the museum and two days looking for a needle in a haystack. Except for the time that the representative of modern art spent sleeping, eating and at rest, then a needle in a haystack, he was looking for 30 hours.
This performance artist arranged to speculate how the words are related to reality. Viewers have neg found, though not much. Call it a spectacular sight tubo at all desire. More startled visitors attracted stack in the lobby.
Answering the question of why he thinks his performance art, Sahsalber replied: “I take a familiar phrase and beat her. My art is associated with ordinary things. “
Artist Sven Sahsalber in the Paris museum 30 hours looking for a needle in a haystack
The museum said that the money for their creativity Sahsalber not received. He only paid the ticket from the US to Paris. Hay was free. One of the local farmers donated the whole stack for contemporary art. However, to come and watch the action Sahsalbera farmer refused, complaining that he was busy.
Earlier Sahsalber not the first time speaks with unusual performances. Previously, he sawed the tree branch on which sit, and spent the whole day in the room with the cow.
“Maybe it looks silly, but I want to experience it all for yourself”, – says the artist. The way we are searching for a needle in a haystack, you can see on YouTube. However, the video clip of 30 hours reduced to 6 hours. As a result, the needle yet was found.
“It may seem silly, but I just want to try it all,” – said the representative of modern art. With regard to looking for a needle in a haystack, then posted on YouTube truncated shooting this action. Its duration of 6 hours. The needle was eventually found.


2. Side benefit. Energy management programs that achieve the most significant savings are typically those whose original goal was to improve control of production processes. The energy savings achieved as a result of improved production processes often covers all or part of the cost of those improvements, which makes it easier to get management and financial support for adding energy reduction activities to automation projects.
3. Involve production, not just facilities management. Involve people responsible for production processes in energy management activities, since up to 90 percent of energy is consumed by production equipment. They will help you ensure that proper steps are taken to understand how process energy consumption can be reduced without affecting the productivity of expensive production assets. The primary reason most companies focus their energy-saving activities on the facility is that facility management personnel are often given the responsibility for reducing energy costs. Not only is the facility in their comfort zone, but it's often the only area where they have the institutional authority to make changes. By involving production, you can address all the areas of your operation that consume energy.
4. Use interns to collect data. It's fairly simple to identify viable energy management projects, but it takes real engineering to develop the business case. Use interns from local universities to collect the actual data points needed to develop a well-founded business case.
5. Avoid duplication. Many motor control devices now have network connections that pass along energy data. There's no need to duplicate these data-generating capabilities by installing power monitors over the top of intelligent motor control devices.
6. Take advantage of incentives. It can often be difficult to find the funds to invest in projects that will reduce energy consumption by your plant. Federal, state and local governments offer a range of incentive and rebate programs for energy saving projects and using alternative energy sources.
7. Be prepared. Before planning for any energy management purchase, it's important to first gather your data. It must cover the entire usage pattern of the equipment. Based on the requirements, choose the technology (hardware and software) that will help in analyzing a combination of parameters instead of a single parameter. Monitor the results and associate operational conditions with energy consumption.
8. Start with your power bill. Look for peak demand charges or power factor charges. If you have a shift come in and get the facility running from a dead stop, this can create a big grid load for a short time and lead to additional kw/hour charges due to the short period amp draw. Work with your facilities to stagger the starting of equipment and lights. When possible, use soft starts or VFDs on large horsepower motors to reduce large start-up currents. Utilize lighting vendors and not just an integrator or electrical contractor to create ROIs based on the real-world numbers you can give them from your power bill and a walk though of your facility. Although the power bill is not always correct, it is the key to cost savings as it is the perfect metric for measurement.
9. Track big consumers. Always make sure you have the means to track the energy performance of large energy consumers. The term "large" can be determined by using a simple Pareto analysis. Make a list of all of your energy users and section off the top 20 percent. This will identify a large portion of your energy usage, as well as the focus of your maintenance activities.
Five ways to manage energy costs
Reducing energy costs from production processes requires managing the five most important factors that determine both utility charges and total energy consumption:
1. Energy event management - Detection and analysis of process changes that cause consumption to exceed forecast.
2. Peak demand management - Minimizing peak demand, which triggers higher utility rates or penalties.
3. Scheduled demand management - Minimizing costs by shifting demand to lower cost time periods.
4. Idle state management - Minimizing energy draw during idle process conditions.
5. Demand/response management, - Offering energy capacity back to the grid on request in exchange for incentives.
Energy assessments and audits can help companies identify a wide range of changes they can make to help reduce their consumption. Audits can be simple, such as a walkthrough of a building or facility to identify quick-hit opportunities, or much more detailed efforts. These are not one-time projects, but rather ongoing efforts to identify variables, such as how seasons might affect production costs and whether previously implemented improvements are continuing to perform as planned.
Such assessments can help to establish the scope of an effort to reduce energy consumption, define key metrics and put resources in place that can take a holistic view of energy for the organization. Recommendations may include low-investment modifications, such as shifting maintenance operations to non-peak times, or may be more involved, such as programming changes to equipment. Evaluation and prioritization of capital improvement opportunities can also be included in the analyses.An assessment, regardless of scale or scope, should help answer the following key questions:Where am I likely to find quick returns?What key metrics should I put in place?How can I encourage ongoing improvements?
For information on the energy incentive programs available in your state or region, go to http://awgo.to/021
Source: U.S. Department of Energy
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text:
On today’s Moment of Science, you’ll hear an exclusive sound recording of what happens when a household fire extinguisher goes bad. The expert said, most fire extinguishers rely on pressurized gas to propel chemicals to put out a fire. Over time, some gas leaks out. That’s why fire extinguishers have expiration dates. To work properly, they need to be recharged to make sure the gas is at the right pressure.
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domain: chemistry


text:
Soroa has a very variable wet weather; owing to its geographical position in the Sierra del Rosario, there are warm zones where there is little vegetation, but the deeply forested zones are much cooler. During the night, the temperature is cool and pleasant.
Temperatures range from 22 to 30 Celsius degrees (65 to 86 Fahrenheit degrees) the whole year.
Santiago de Cuba Tourism Carnival in Santiago de Cuba ? Arguably Cuba's most extravagant Carnival, each year rivalry for the top spot against Havana and Remedios makes every Carnival more extravagant than the last. [...] Cayo Coco Cuba Tourism All About Cuba Cayo Coco ? The best place to really relax in Cuba. Kilometers of pristine white sand beaches and shallow warm Caribbean Sea. Cayo Coco is located in [...] Cayo Largo Cuba Tourism This brings a whole new dimension to living on the beach, right? Villa Coral in www.CubaCayoLargo.com would be happy to accommodate you. Come anytime, the weather never really changes in [...] Pinar del Rio Cuba Tourism Wow this country life is hard! Mom and Pop went in for a snooze, one sister fell asleep but the other is still wide wake! People from Pinar del Rio [...] Largest Hotel in Cuba We are not sure which was the harder task, building the almost 1000 room Hotel Playa Pesquero on the white sands of Holguin or bringing this massive steam train which is [...] Cuban Coins Cuban coins feature the Cuban national symbol of a five pointed star and Patria y Libertad “Fatherland and Freedom” which is written on this coin from 1943 given to us in www.CubaOldHavana.com


text:
DENVER — Blues fans will have to wait a bit longer to see their newest offensive addition in action.
About a half hour before the Blues were set to take the ice against the Colorado Avalanche to open the season, the team announced forward Mike Hoffman wouldn't be playing.
Hoffman's work visa has not yet been approved. Hoffman is a native of Canada. He is expected to be eligible for the team's second game of the season on Friday.
Hoffman signed a one-year contract worth $4 million with the Blues on Monday after agreeing to a tryout contract with the team in December.
The 30-year-old forward led the Florida Panthers in goals last season with 29 and has scored 20 or more goals in six consecutive seasons.
He was originally drafted by Ottawa in the fifth round of the 2009 NHL Draft.


It was not just the top end of the Premier League table which was involved in final day of the season drama. Bournemouth and Watford both suffered relegation, to join Norwich City in dropping down to the Championship.
For Manchester United this meant reported top transfer target Jack Grealish becomes more difficult and expensive to sign with Aston Villa stay up. The Times reports the player fears he will be priced out of a move.
On the other hand however, there are players at the three relegated sides who it may be possible to strike bargain deals for.
Leicester snapped up Harry Maguire in this same way from Hull City, while Liverpool did the same successfully with Andrew Robertson.
So here is a look at five quality relegated players who Manchester United could look at making moves for this summer…
Gary Neville tipped Idrissa Sarr as a potential alternative to Jadon Sancho earlier this month, The Mail reported.
Sarr, 22, is a talented yet inconsistent player, who showed his potential with two goals and an assist against Liverpool to defeat them back in February.
He also won a penalty and scored in Watford’s win over United, and provided an assist against Arsenal on the final day as the Hornets were relegated.
Sarr’s pace and movement causes problems for opponents, and while we are still confident the club will sign Sancho, the Senegal international becomes an interesting additional option now Watford are relegated.
Ake would add balance to United’s defence as a left-footed centre-back and he is unlikely to play Championship football next season.
He is durable like Maguire in that he rarely misses a game, and The Times report Ake is on United’s shortlist.
The Guardian report Manchester City are also keen on Ake, so United may have to move fast.
He has Premier League experience and may be available for around £30 million, less than half the price Bournemouth wanted for him last summer.
If United want a budget creative option to back up Bruno Fernandes, then Emiliano Buendia might be a shrewd addition.
Playing for a struggling Norwich side, Buendia stood out with a record among the best in the Premier League.
He created an average of 2.3 chances per game, the fourth best in the top flight among players who featured in 10 games or more.
This led to seven assists, and mixed in with United’s superior attackers, 23-year-old Buendia could become a force to be reckoned with.
Young star David Brooks missed most of Bournemouth’s campaign with injury.
A goal late in the season against City was a brief flash of his potential. at just 23, Brooks has a lot to give, and could become a useful option on United’s right side.
In the past he has been valued by Bournemouth at £50 million, and this is an opportunity for United to buy him on the cheap.
In 2018/19 Brooks managed to score seven goals and provide five assists. He may be worth taking a punt on.
If United want a versatile midfielder capable of everything, then Abdoulaye Doucoure could be the man.
The Frenchman has been one of Watford’s most consistent performers for three seasons now and at 27, is very capable of playing a useful role for United.
He scored four goals and provided two assists this past campaign, and needs a move to give his career a boost.
As a back-up, Doucoure can be a solid option at Old Trafford, as he is able to play both an attacking role deputising for Fernandes, or as a defensive midfielder filling in for Nemanja Matic.
- Michael Owen says he expects Manchester United to challenge for the title
- Manchester United fans predict Sancho deal will be announced on the 7th
- A look back at Ethan Laird’s statement of intent for United one year ago
- The cost of slashing Jack Grealish’s asking price may be one Solskjaer won’t want to consider
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After compiling a list with the 10 most congested cities and freeways in North America, Navteq, a provider of maps, traffic and location data, is back with a similar survey, this time regarding Western Europe. The list is based on a mix of criteria, including the greatest rush hour delay, and is comprised of cities with more than one million inhabitants.
And the winners or shall we say the...losers are:
Top 10 Most Congested Western European Cities
According to Navteq, aside from traffic incidents, time of day and weather, traffic is also influenced by constant factors, such as topographical circumstances, structure of public transportation and the way population and working places are dispersed throughout a given urban area.
“These circumstances and many others intersect with time to produce traffic”, says Andreas Erwig, Director, Navteq Traffic Europe. “Because the fascinating complexity of traffic is that it's not only about movement from here to there, but from now to then”.
By Csaba Daradics


text:
12:22 PM EDT 04/18/2015
Originally posted 04/16/2015 07:10AM
Proving it's never too late to say, "I'm sorry," comedian Louis C.K. earned a warm response from former vice presidential nominee Sarah Palin after apologizing to her for the vile things he Tweeted about her – almost five years ago.
Originally posted 03/14/2015 07:20PM
Sarah Palin is proud that she will soon be the mother-of-the-bride.
Originally posted 03/14/2015 12:45PM
Bristol Palin is officially off the market.
Originally posted 02/16/2015 12:50PM
Did the politician go shopping in her daughter's closet?
Originally posted 02/16/2015 09:50AM
Tina Fey, Sarah Palin has a bone to pick with you.
While on the carpet ahead of Saturday Night Live's 40th anniversary special, the former Republican VP candidate called out Fey for not sharing the wealth.
"Well, have I helped her career or has she helped mine? I'm like come on Tina, you should be paying my kids' braces or something," Palin told reporters when asked whether being impersonated by Fey on the series had helped her career.
Originally posted 02/04/2015 03:40PM
Live from New York, it's ... Sarah Palin!
Originally posted 01/24/2015 02:00PM
When it comes to supporting military families, Taya Kyle – widow of Chris Kyle, the former Navy SEAL who's portrayed by Bradley Cooper in American Sniper – is on the front lines.
Originally posted 01/21/2015 03:25PM
The real-life American Sniper, Chris Kyle, was more than "an ultimate warrior," says Sarah Palin, he was her friend.
Originally posted 01/20/2015 06:15PM
Sure, Sarah Palin can be quick to pounce when something rubs her wrong.
Originally posted 01/04/2015 07:35PM
The Internet went crazy earlier this week when Sarah Palin posted a photo of her 6-year-old standing on top of their dog – and the politician has now responded to the controversy.
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domain: celebrity


Five-year-old Saroo finds himself alone and travelling on the wrong train away from his home in northern India.... Read more...
9th Jun 2012 3:15pm | By Editor
Are you a karaoke fan?
Get down to this new weekly night where you can tackle the best soul, hip hop and R&B with a full five-piece live band. Top stuff! Take that Belinda Carlisle!
Thurs, June 14. 11pm-3am £5
8-10 Brewer Street, W1F 0SE
Tube | Tottenham Court Road


text:
70's mini green crochet blanket
70's crochet blanket.
100% handmade granny square crochet blanket.
For the sofa, beds, table, desk...
We would highly recommend it either for daily use or gift idea.
It would be perfect for friends and family, granny, mom, or daughter because you can't make a mistake with a handcrafted item using the most classic and simple motif pattern.
Absolutely unique finds in excellent condition.
Handwash gently in cool or lukewarm water and lay flat to dry
72 x 60cm

domain: design


text:
ATF4 is constitutively expressed in rheumatoid arthritis (RA) synovium, but translocated into the nucleus by C/EBPβ-LIP.
(A) Expression and distribution of ATF4 in RA synovium by immunofluorescence staining. Original magnification, 200×. (B) Expression of ATF4 protein levels from fibroblast-like synoviocytes from the synovium of RA patients (RA-FLS) by western blotting. ATF4 protein in HeLa cells was used as a positive control. (C) Expression of ATF4 mRNA of RA-FLS overexpressed C/EBPβ by quantitative RT-PCR. Isolated RA-FLS were transfected with adenovirus expression vectors for C/EBPβ-LAP, −LIP or LacZ control. The level of ATF4 mRNA relative to LacZ control is shown. (D) Synovial tissue from RA patients was cultured in serum-free medium for 24 hours and then replaced with fresh medium containing adenovirus expression vectors for C/EBPβ-LIP or LacZ control for a further 72 hours. Immunostaining for ATF4 was performed. Original magnification, 400 × .

domain: biology


Earlier this year the Lego Group and Nintendo announced a partnership. This clearly has some intriguing possibilities. Unfortunately, the first products shown seemed to miss the potential. However, this changed with the announcement this week of a Lego set built around the classic NES. Lego and Nintendo are two classic toy brands for kids. However, both companies have been around for so many years that they have a large and growing adult fan base. This is …..
Surprise, Sony not only revealed games, but they gave the world a glimpse of the PlayStation 5 design. With the PlayStation 5 having a large existing advantage over the Microsoft Xbox Series X, does this reveal change the analysis? This time of year, the video game industry was supposed to be gathering at the E3 show in Los Angeles. This was the place to reveal new consoles like the PlayStation 5 and Xbox Series X. Of course, COVID-19 killed this year’s show. …..
In the recent DFC Intelligence Video Game Forecast, we modeled both the PlayStation 5 and Xbox Series X to launch in 2020. In Sony’s recent fiscal year earnings and forecast releases the company has confirmed the PlayStation 5 launch is still on track for holiday 2020. Assuming that hardware launches are on track the big remaining question is how many units will a…..
DFC Intelligence just released its latest report on the state of the video game industry. The good news is that sales of video games are soaring. Of course, one of the unfortunate causes of this increase is the devastating spread of COVID-19. In the past week major public video companies have reported earnings results that were better than expected. This included Activision Blizzard, Electronic Arts, Ubisoft, Zynga and Nintendo. These …..
Elder Scrolls is a 25-year old action role-playing series set in a fantasy universe. Like many franchises with tens of millions of users, observers are starting to ask whether products like Elder Scrolls have the potential to become a metaverse. The concept of a metaverse is a hot buzzword in video games. A metaverse is basically a virtual 3D space where users can interact with each other. Not only can they communicate but they can build their own environments…..
On April 10, Square Enix released Final Fantasy VII Remake. This game was based on the 1997 hit PlayStation title. Rereleasing classic titles is not new. However, what Square Enix is doing with Final Fantasy VII Remake is taking a historic franchise and making it into a billion dollar plus product. Upon its release, Final Fantasy VII was seen as a key driver for the first PlayStation system. At the time Square, along with then competitor Enix, had the best-sel…..


Flood victims in the African country of Benin need urgent help to survive, an aid agency says.
About 700,000 people have been affected by the continuing deluge, with more than 200,000 left homeless.
Crops, food supplies and livestock have been washed away, says Care International.
Some 200,000 people need food aid to survive until the harvest next April, while standing water is raising the risk of water-borne diseases.
‘Latrines have been flooded out, spreading waste in the same water people are using to cook and bathe with,’ said Huguette Sekpe, of Care.
‘Families have told us children are already suffering from diarrhoea.’
Care has appealed for £625,000 to give food, water purification tablets, shelter materials and other supplies to 50,000 people.
To help, visit http://www.careinternational.org.uk.