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10 Best Bed And Breakfasts To Stay In Pendé Picardy – Top Hotel Reviews
Pendé Picardy is beautiful and has lots of bed and breakfasts. Ofcourse we are only looking for the best bed and breakfasts in Pendé Picardy. It’s important to compare them because there are so many places to stay in Pendé Picardy. You’re probably wondering where to stay in Pendé Picardy. To see which bed and breakfast sounds better than the other, we created a top 10 list. The list will make it a lot easier for you to make a great decision. We know you only want the best bed and breakfast and preferably something with a reasonable price.
Our list contains 10 bed and breakfasts of which we think are the best bed and breakfasts in Pendé Picardy right now. Still, some of you are more interested in the most popular bed and breakfasts in Pendé Picardy with the best reviews, and that’s completely normal! You can check out the link below.
10 Best Bed And Breakfasts In Pendé Picardy:
Les Iris de la Baie de Somme
Located in Pendé, Les Iris de la Baie de Somme is 3.1 miles from Saint-Valery-sur-Somme and its ramparts. It offers free Wi-Fi, a terrace with outdoor furniture and a soundproofed room with a flat-screen TV.With cathedral ceilings, the colourful room features a wardrobe and a private bathroom with a shower and a hairdryer.Guests are invited to enjoy a continental breakfast every morning at Les Iris de la Baie de Somme. A coffee machine, a fridge and an electric kettle are at guests’ disposal.This property is 3.1 miles from the Somme Bay and 12.4 miles from Abbeville Golf Course. The A28 motorway is 13 miles away and free private parking is available on site.
Very well equipped en-suite room with fridge and facilities for making drinks. Bed very comfortable and powerful shower! Quiet location – 5 mins drive from restaurants in St Valery of which there are many. Gates locked at night so parking secure.
- Bed large and comfortable. Bread, croissants, cheese and jam very good.
Owners are a friendly couple who were very attentive, even though we spoke little french!
We had lovely fresh eggs for breakfast from their hens, homemade jams and tarts.
- Very friendly welcome. Room, bed and bathroom very comfortable .
Des hôtes accueillants et bienveillants ! Simplicité et réussite.
Une bonne adresse.
- Very well equipped en-suite room with fridge and facilities for making drinks. Bed very comfortable and powerful shower! Quiet location – 5 mins drive from restaurants in St Valery of which there are many. Gates locked at night so parking secure.
La Ferme du Parc
Showcasing a sun terrace and views of the garden, La Ferme du Parc is located in Pendé. Free WiFi is featured and free private parking is available on site.For your comfort, you will find free toiletries and a hairdryer. A flat-screen TV is provided.Le Touquet-Paris-Plage is 25 miles from La Ferme du Parc, and Dieppe is 28 miles from the property. The nearest airport is Le Touquet Airport, 25 miles from the property.
- Room size was good, and the owner very hospitable. Shower and handbasin in ensuite looked new and worked perfectly. Very quiet. Evening shade on the front lawn and you can have a table and chairs outside to cool off.
- A lovely rural location. Terrific facilities. Simple but filling breakfast delivered to the the patio in the morning.
- Accommodation really nicely done and lots of space
- A lovely old farmhouse set in a beautiful, quiet location. Basic but clean accommodation. Simple but adequate breakfast.
- If you are looking for peace and quiet this is it… a bit off the beaten track, but very kind reception and comfortable accomodation. If you go for a stroll in the morning all the sheep will come running at you (behind their barbed wire)… a real farm-style experience!
Chambres d’hôtes L’Abri Cotier Rue de la Baie
Featuring free WiFi and a playground, Chambres d’hôtes L’Abri Cotier Rue de la Baie offers pet-friendly accommodations in Saint-Valéry-sur-Somme, just 24 miles from Le Touquet-Paris-Plage. Free private parking is available on site.Every room is equipped with a flat-screen TV. You will find a kettle in the room. Every room comes with a private bathroom fitted with a bathtub or shower.You will find a 24-hour front desk at the property.Free use of bicycles is available at this bed and breakfast and the area is popular for biking. Dieppe is 29 miles from B&B L’Abri Cotier Rue de la Baie, and Le Crotoy is 3.2 miles from the property. The nearest airport is Le Touquet Airport, 24 miles from the property.
- Qualité de l accueil chaleureux et bon rapport qualité prix à encourager
- Confort de la chambre, au calme et un accueil chaleureux
La gentillesse des hôtes aux petits soins et leur disponibilité
Nous y retournerons avec plaisir
- ON A TOUT AIME SURTOUT LA GENTILLESSE ILS SONT TOUS LES DEUX A NOS PETITS SOINS CHAMBRE TRES TRES PROPRE PETIT DEJEUNER COPIEUX LE CALME BRAVO A VOUS DEUX CONTINUEZ BISOUS
Chambre aménagée avec goût
Location de vélos sur place
Service pour prendre un café ou un thé en chambre
Linge de lit impeccable
Linge de toilette moelleux
Le Vrai Paradis
Located in Estréboeuf in the region of Picardie, 25 miles from Le Touquet-Paris-Plage, Le Vrai Paradis features a terrace and views of the river. Free private parking is available on site.Each room has a flat-screen TV. Some accommodations feature a sitting area to relax in after a busy day. You will find a kettle in the room. The rooms have a private bathroom. For your comfort, you will find free toiletries and a hairdryer.There is a shared lounge at the property.Dieppe is 29 miles from Le Vrai Paradis, and Saint-Valéry-sur-Somme is 2.2 miles away. Le Touquet Airport is 25 miles from the property.
- Excellent location for the Baie de Somme. Good and helpful host and hostess. Fresh produce including home made jams as part of excellent breakfast.
- The nicest couple run this location. They are wonderful, charming and down to earth and were very helpful in assisting me to find a solution to my car problem. The husband speaks pretty good english, enough to where there was no problem having many conversations with him. I definitely recommend staying here for anyone traveling to or through the area.
- Very good place for a stop-over on way to Car Ferry, Breakfast excellent, with wide choice of home made or local produce. Very close to Saint Valery Sur Somme, with its marina, restaurants and steam train and wonderful views over the Baie de la Somme.
- Everything was fine which is why I returned there after a previous visit
- Our room was in a converted outbuilding in the the garden, which sounds quite off-putting, but read on: the window had a wind-down white shutter, that side of the room looks onto the car parking area and some garden. It had a large well decorated bedroom with big wardrobe, chairs, quite large table, fridge, kettle, teas and coffee, TV, patio doors, private patio with table and sunloungers. The bathroom was a fully-tiled wet-room with shower, basin with vanity unit and a toilet. The room would be OK for self catering for a few days. Breakfast was good – croissants, breads, jams, cereals etc. The location near St Valery sur Somme is excellent – no more than a 5 minute drive.
L’Escale de la Baie de Somme
L’Escale de la Baie de Somme is located in Le Crotoy, 21 miles from Le Touquet-Paris-Plage and 2.5 miles from Saint-Valéry-sur-Somme. Free WiFi is featured throughout the property and free private parking is available on site.All rooms include a TV. Certain units include a sitting area to relax in after a busy day. Each room includes a private bathroom equipped with a shower.You will find a shared kitchen at the property.The bed and breakfast also provides bike rental. Berck-sur-Mer is 13 miles from L’Escale la Baie Somme, and Le Tréport is 16 miles away. The nearest airport is Le Touquet Airport, 20 miles from L’Escale de la Baie de Somme.
- Nice apartment, well equipped & furnished with good location. Breakfast, served downstairs, was good & fresh. Plenty of parking and the crowning glory was the Swimming Pool. Small but indoor & great for kids. Would definitely stay again.
- Lovely location and excellent facilities in the apartment.
- Swimming pool welcome in the hot weather and having use of kitchen facilities.
Location and parking. Good, clean room. Very good breakfast – excellent croissants.
Covered swimming pool.
- Very nice greeting. Lovely spot and very quiet. Great place to catch up on on the hectic activities before arriving.
Les Chambres de Pascaline
Les Chambres de Pascaline offers accommodations in Arrest. Free private parking is available on site.Every room has a private bathroom.Le Touquet-Paris-Plage is 27 miles from Les Chambres de Pascaline, and Dieppe is 28 miles from the property. The nearest airport is Le Touquet Airport, 26 miles from Les Chambres de Pascaline.
- The tranquility of the place, the rural environment, the cleanliness and the style of the accommodation, the kindness and the efficiency of our hostess.
- Large comfortable bed and beautifully clean bathroom facilities. Breakfast was typical French style of bread, croissants and jam and laid out ready every morning.
- The excellent breakfast was included in the daily rate and, all in all, the stay was fantastic value for money.
- L’acceuil,le déjeuner croissants,café bien chaud,confiture,yaourt,baguette,la literie impeccable et la propreté
- L endroit et très calme et reposant . Pascaline et très accueillante et disponible . Très bon petit déjeuner à la française. Aucune fausse note sur la propreté des chambres .
Les Portes Du Hable
Featuring free WiFi, a playground and a terrace, Les Portes Du Hable offers accommodations in Cayeux-sur-Mer. Free private parking is available on site.Certain units feature a private bathroom with a spa tub, and others have bathrobes and slippers. Certain rooms include a sitting area for your convenience. You will find a kettle in the room. Extras include free toiletries and a hairdryer. A flat-screen TV is available.You will find a shared lounge at the property.Le Touquet-Paris-Plage is 25 miles from Les Portes Du Hable, and Dieppe is 25 miles away. Le Touquet Airport is 25 miles from the property.
- Thank you Celine and Pascal. We enjoyed our stay. Beautiful place, very clean and neat, breakfast was excellent. Good hospitality. Children play area was added bonus. About 2km from the hotel there is beach, restaurant and supermarket.
- Hosts were extremely friendly and provided a great dinner and breakfast, location a couple of KM’s out of town, but was not an issue for us as we were on a cycling holiday.
- Able to walk my dog in the grounds of the property.
Un accueil superbe
Un grand instant de bonheur
Chambre décorée avec goût
Literie super et petit déjeuner au top
Avec en plus un temps radieux
Nous reviendrons, c’est évident 👍
Michel et Ludmila
Les propriétaires sont charmants et la propreté des lieux est parfaite.
Le petit déjeuner très bon.
La décoration des chambres et de l’ensemble de la propriété est soignée et reposante car elle contribue a créer une ambiance zen.
Suivez le Lapin Blanc
Featuring free WiFi throughout the property, Suivez le Lapin Blanc offers accommodations in Saint-Valéry-sur-Somme.All rooms are fitted with a flat-screen TV. Some rooms include a sitting area to relax in after a busy day. Enjoy a cup of tea while looking out at the garden or city. All rooms have a private bathroom. For your comfort, you will find free toiletries and a hairdryer.There is luggage storage space at the property.Le Touquet-Paris-Plage is 23 miles from Suivez le Lapin Blanc, and Dieppe is 31 miles from the property. Le Touquet Airport is 23 miles away.
- This is an experience. We were in the Mary Popping suite. It was charming and great fun. I love the whole idea of the hotel. We will be back again.
A lovely building in a great location. Our room was as expected, clean, comfortable, warm, good facilities and as promised had a Movie theme.
The owners were friendly and accommodating and despite our very poor knowledge of the French language, were happy to speak English. Breakfast was simple but really tasty with a good choice of bread, cake and pastries with the option of additional cheeses, cold meats and eggs if required. Tea and coffee in the room with a kettle.
We had to cut our trip slightly short due to my Wife not being well but I would certainly recommend this establishment to anyone staying in the area.
- Very nice room and nice French breakfast..the hosts were very welcoming and we spent 2 wonderful nights
- The rooms were amazing, qwerty, but so clever. Really comfortable. Breakfast was brilliant. Nothing was too much trouble.
We stayed in the Lawrence of Arabia suite, which was very big and comfortable. There was a separate sitting room which was lovely and it was filled with Arabian themed items, such as an old-fashioned suitcase filled with books about T E Lawrence, a fez, hookahs and Ali Baba basket, complete with resident toy snake! The decor was similarly inspired by Arabia and the bathroom was beautiful. There was a great deal of attention to detail to make your stay very comfortable and a wonderful range of teas in the room. A good breakfast with the local speciality cake. Our room overlooked the garden, so it was very peaceful.
La Ferme d’Antan Baie de Somme
Featuring free WiFi, La Ferme d’Antan Baie de Somme offers accommodations in Mons-Boubert. Free private parking is available on site.A flat-screen TV is provided.Le Touquet-Paris-Plage is 27 miles from La Ferme d’Antan Baie de Somme, and Dieppe is 30 miles from the property. The nearest airport is Le Touquet Airport, 27 miles from La Ferme d’Antan Baie de Somme.
- The room was very comfortable and our son was delighted to have his own room off ours with his own loo too! Breakfast was great. Eddy, the owner, spend time with use recommending things to do in the area and was very hospitable. I would certainly choose to stay here again.
Room / Property fitted out to a very standard – Room spacious and very comfortable.
Eddy very helpful with local information.
Village location very peaceful.
- The welcome and advice on what to do in the area. The availability of lounge, fridge, and tea/coffee making facilities throughout stay was good. Room very comfortable, high-spec and clean.
- Endroit tranquille, campagnard et calme, petit dej.copieux, varié et servi dans un cadre agréable, la chambre cosy et confortable.
Les propietaires sont charmants et de très bons conseils.
La chambre est spacieuse, bien aménagée et bien insonorisée. Le lit est confortable. L’environnement est calme et la situation géographique est idéale.
This property is a 12-minute walk from the beach. Featuring free WiFi and a sun terrace, Les Blancarts offers accommodations in Hautebut, just 28 miles from Le Touquet-Paris-Plage. Free private parking is available on site.All rooms come with a flat-screen TV. Every room has a private bathroom.Dieppe is 23 miles from Les Blancarts, and Saint-Valéry-sur-Somme is 8 miles away. The nearest airport is Le Touquet Airport, 27 miles from Les Blancarts.
- Perfect for hiking! On outskirts of Ault (a couple km away) but very close to trailheads. Friendly welcome (note: don’t rely on Google Maps, call).
- Very welcoming proprietors. Generous and high quality breakfasts with home made jam and cakes. Good croissants and bread. Very large and comfortable bed. Madame gave me some strawberry plants from her garden.
- Spacieux, confortable et bien situé avec un super petit dej tous les matins ! Je recommande cet établissement
Chambre très propre et décorée avec goût. Literie confortable.
Magnifiques petits déjeuners copieux. Un vrai régal !
Bref, nous sommes enchantés de notre séjour. Merci aux propriétaires !
- Tout est mis en oeuvre pour nous faire plaisir. Nous avons été reçus comme des princes par des gens authentiques et sympathiques dont le but est de rendre le séjour des plus agréables. Le petit déjeuner est divers et en quantité plus que suffisante. Merci encore.
Top Bed And Breakfasts In Pendé Picardy Conclusion:
The above is a top selection of the best bed and breakfasts to stay in Pendé Picardy to help you with your search. We know it’s not that easy to find the best bed and breakfast because there are just so many places to stay in Pendé Picardy but we hope that the above-mentioned tips have helped you make a good decision.
We also hope that you enjoyed our top ten list of the best bed and breakfasts in Pendé Picardy. And we wish you all the best with your future stay!

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Tailor-made solutions for your development
ASH design + assessment are specialists in landscape design, landscape planning, landscape management, environmental impact assessment and environmental management.
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Email ASH or call 0141 227 3388 to find out whether ASH design + assessment can provide professional advice and consultancy for your development.

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There is some good news for the Memorial Day weekend.
Yes, there will be showers and thunderstorms, but Memorial Day itself now looks to be precipitation-free, and could even be sunny for much of the afternoon.
Here's a day-by-day breakdown of what to expect:
- Saturday: Partial sunshine and very humid during the day with a high temperature in the mid-80s. There is a slight chance of showers and thunderstorms late in the afternoon, with the showers during the evening and a higher chance of storms up until 10 p.m. An Air Quality Alerts is in effect from 11 a.m. to 11 p.m. Saturday for Westchester, Rockland and Fairfield counties.
- Sunday: Cloudy throughout the day with rain likely through the morning and early afternoon. The daytime high will be in the mid-60s. There could be more rain during the evening. Total rainfall of up to a half-inch is possible.
- Memorial Day: Cloudy through the morning before becoming mostly sunny in the afternoon with a high in the low-70s. It will be partly cloudy in the evening with an overnight low around 60.
Check back to Daily Voice for updates.
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text: +Creamy, smooth and delicious. This is the perfect risotto!For more tasty recipes, visit foodinaminute.co.nz Use our conversion chart User ratingRate this recipe12345red wine lamb curry pie pasta avocado tortilla nuts apple coconut raspberries berry banana smoothie ice cream pudding roast vegetable salmon tart biscuits chocolate cake vanilla couscous salad muesli slice burritos tacos mexican prawn prawns surimi pea ham soup muffins frittata cheese leek pizza stir fry shanks mushroom italian shellfish cranberry spinach venison potato fish Potatoes Lunch Cheesecake Dessert Summer Cupcakes Main Fruit Yoghurt Greek vegetarian snack Drink gluten free Mains Entree Breakfast Baking Snacks spaghetti wattie's steak Father's Day Recipe Ideas Lunchbox Entertaining Casserole Pams Chicken Rice Asian Bacon School Holiday Recipes Pumpkin beef Christmas sweet healthy mussels vegetables Great New Zealand Baking Book afternoon tea raw no-bake Meal Type:MainsPrep Time:0 - 15 minsCooking Time:15 - 30 minsServes:2 - 3By:Food in a MinuteIngredients1 cup Wattie's frozen Baby Peas (for the pea puree) 10g butter (for the pea puree) 2 Tbsp chicken stock or water (for the pea puree) 2 1/2 cups (625ml) chicken stock 1 small leek, trimmed, sliced and washed 1 cup risotto rice (Carnaroli or Arborio) 1/2 cup (125ml) dry white wine 1 cup Wattie's frozen Baby Peas Zest and juice of 1/2 lemon 50g traditional feta, crumbled InstructionsTo make the pea puree put Wattie’s frozen Baby Peas, butter and stock in a microwave proof bowl. Cover. Microwave on high for 2-3 minutes, until peas are hot. Place peas and cooking liquid into a food processor or blender and process until smooth. Set aside. Now to make the risotto: Heat chicken stock until almost boiling. Set aside. Heat a dash of oil in a large saucepan. Add sliced leek and cook over a medium heat until leek starts to soften but not brown. Add rice and stir until the grains whiten. Pour in wine and allow to reduce by half. Add 2 cups of hot stock and stir. Bring to the boil. Reduce heat. Cover and simmer for 15 minutes, stirring halfway through cooking. Stir in Wattie’s frozen Baby Peas. Continue cooking for a further 5 minutes, adding extra stock if necessary until rice is tender. Carefully stir through prepared pea puree, lemon zest and juice and crumbled feta. Season to taste.

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Middleburg Heights to offer residents $2,500 grants to fix sanitary sewer issues
MIDDLEBURG HEIGHTS, Ohio – Even with all the preventive measures Middleburg Heights officials have taken, and continue to take, in public areas to minimize sanitary sewer backups during heavy rains, additional corrective measures on the private side could be taken by residents to remediate their problems.
That is the thought behind the Sanitary Sewer Backup Reduction (SSBR) grant program set to begin Sept. 26. It is designed to provide direct financial assistance to homeowners who experienced a sanitary sewer backup on or after July 20, 2023.Mayor Matt Castelli and his administration hope an up-to-$2,500 incentive per household will lead to residents correcting sanitary sewer infrastructure problems in their homes. Such basement flooding must be unrelated to a failure of the owner’s private septic system.


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Objective: Incidence rates of colon and liver cancers differ dramatically between Northern vs. Southern India. It has been suggested that differences in regional diet may play a role, specifically in the disparity in consumption rates of curcumin, an active agent of turmeric, and epigallocatechin gallate (EGCG), a compound in green tea. Curcumin and EGCG have well-known multi-targeted and beneficial effects as chemopreventive agents. However, natural compounds typically require high concentrations to be effective, which can also negatively impact healthy cells. Alternatively, low-dose combination of these compounds, if proven effective, may be one way to avoid this problem. This study proposed to demonstrate the effects of individual and combined treatments of EGCG and curcumin on viability and cancer pathway signaling, in hepatocellular carcinoma (HCC) and colorectal cancer (CCR) cell lines.
Methods: HCC and CCR cell lines (HepG2 and SW1417, respectively) were treated with curcumin and EGCG in a dose- and time-dependent manner. Regorafenib, a chemotherapeutic used to treat colon and liver cancers, was then combined with the effective low-dose EGCG/curcumin. Cell viability, proliferation, and expression of cancer target genes were assessed.
Results: Low-dose combination of curcumin and EGCG influenced the expression of 28 cancer target genes in HepG2 and 14 genes in SW1417. Six of these targets were verified by quantitative polymerase chain reaction. Regorafenib treatment elicited an effect similar to curcumin + EGCG treatment in a number of these targets and enhanced their regulation when used in combination.
Conclusions: Low-dose combinations of curcumin and EGCG have a beneficial effect on regulating important cancer targets in HepG2 and SW1417 cell lines. The data suggest a supportive role for phytochemicals as complementary treatments to chemotherapy.
1. Heron M. Deaths: leading causes for 2017. Natl Vital Stat Rep. 2019;68:1–77.
2. Kumar D, Kumar M, Saravanan C, Singh SK. Curcumin: a potential candidate for matrix metalloproteinase inhibitors. Expert Opin Ther Targets. 2012;16(10):959–72.
3. Villanueva A, Newell P, Chiang DY, et al. Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis. 2007;27(1):55–76.
4. Le Marchand L, Wilkens LR, Hankin JH, et al. A case-control study of diet and colorectal cancer in a multiethnic population in Hawaii (United States): lipids and foods of animal origin. Cancer Causes Control. 1997;8(4):637–48.
5. Lin JK, Chang SC, Yang YC, Li AF. Loss of heterozygosity and DNA aneuploidy in colorectal adenocarcinoma. Ann Surg Oncol. 2003;10(9):1086–94.
6. Takayama T, Miyanishi K, Hayashi T, et al. Colorectal cancer: genetics of development and metastasis. J Gastroenterol. 2006;41(3):185–92.
7. Wang H, Khor TO, Shu L, et al. Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anticancer Agents Med Chem. 2012;12(10):1281–305.
8. Ames BN, Gold LS, Willett WC. The causes and prevention of cancer. Proc Natl Acad Sci USA. 1995;92(12):5258–65.
9. Quideau S, Deffieux D, Douat-Casassus C, Pouysegu L. Plant polyphenols: chemical properties, biological activities, and synthesis. Angew Chem Int Ed Engl. 2011;50(3):586–621.
10. Shimizu M, Adachi S, Masuda M, et al. Cancer chemoprevention with green tea catechins by targeting receptor tyrosine kinases. Mol Nutr Food Res. 2011;55(6):832–43.
11. Singh S, Loke YK, Furberg CD. Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA. 2007;298(10):1189–95.
12. Agrawal DK, Mishra PK. Curcumin and its analogues: potential anticancer agents. Med Res Rev. 2010;30(5):818–60.
13. Takeuchi T, Ishidoh T, Iijima H, et al. Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda. Genes Cells. 2006;11(3):223–35.
14. Shin HJ, Baek KH, Jeon AH, et al. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell. 2003;4(6):483–97.
15. Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol. 2002;2(10):725–34.
16. Bhattacharyya S, Mandal D, Saha B, et al. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. J Biol Chem. 2007;282(22):15954–64.
17. Prasad CP, Rath G, Mathur S, et al. Potent growth suppressive activity of curcumin in human breast cancer cells: modulation of Wnt/beta-catenin signaling. Chem Biol Interact. 2009;181(2):263–71.
18. Rinaldi R, Eliasson E, Swedmark S, Morgenstern R. Reactive intermediates and the dynamics of glutathione transferases. Drug Metab Dispos. 2002;30(10):1053–8.
19. Strimpakos AS, Sharma RA. Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal. 2008;10(3):511–45.
20. Gupta SC, Patchva S, Koh W, Aggarwal BB. Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol. 2012;39(3):283–99.
21. Fajardo AM, Piazza GA. Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention. Am J Physiol Gastrointest Liver Physiol. 2015;309(2):G59–70.
22. Sigler K, Ruch RJ. Enhancement of gap junctional intercellular communication in tumor promotertreated cells by components of green tea. Cancer Lett. 1993;69(1):15–9.
23. Gupta S, Hastak K, Afaq F, et al. Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappa B and induction of apoptosis. Oncogene. 2004;23(14):2507–22.
24. Masuda M, Suzui M, Weinstein IB. Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines. Clin Cancer Res. 2001;7(12):4220–9.
25. Kissel M, Berndt S, Fiebig L, et al. Antitumor effects of regorafenib and sorafenib in preclinical models of hepatocellular carcinoma. Oncotarget. 2017;8(63):107096–108.
26. Rolfo C, Bronte G, Sortino G, et al. The role of targeted therapy for gastrointestinal tumors. Expert Rev Gastroenterol Hepatol. 2014;8(8):875–85.
27. Aggarwal ML, Chacko KM, Kuruvilla BT. Systematic and comprehensive investigation of the toxicity of curcuminoidessential oil complex: a bioavailable turmeric formulation. Mol Med Rep. 2016;13(1):592–604.
28. Wenger RH, Gassmann M. Oxygen(es) and the hypoxiainducible factor-1. Biol Chem. 1997;378(7):609–16.
29. Chandel NS, Simon MC. Hypoxia-inducible factor: roles in development, physiology, and disease. Cell Death Differ. 2008;15(4):619–20.
30. Liang Y, Li WW, Yang BW, et al. Aryl hydrocarbon receptor nuclear translocator is associated with tumor growth and progression of hepatocellular carcinoma. Int J Cancer. 2012;130(8):1745–54.
31. Kozak KR, Abbott B, Hankinson O. ARNT-deficient mice and placental differentiation. Dev Biol. 1997;191(2):297–305.
32. Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer. 2002;2(1):48–58.
33. Huang CR, Lee CT, Chang KY, et al. Down-regulation of ARNT promotes cancer metastasis by activating the fibronectin/integrin beta1/FAK axis. Oncotarget. 2015;6(13):11530–46.
34. Rychli K, Huber K, Wojta J. Pigment epitheliumderived factor (PEDF) as a therapeutic target in cardiovascular disease. Expert Opin Ther Targets. 2009;13(11):1295–302.
35. Hoshina D, Abe R, Yamagishi SI, Shimizu H. The role of PEDF in tumor growth and metastasis. Curr Mol Med. 2010;10(3):292–5.
36. Wietecha MS, Krol MJ, Michalczyk ER, et al. Pigment epithelium-derived factor as a multifunctional regulator of wound healing. Am J Physiol Heart Circ Physiol. 2015;309(5):H812–26.
37. Becerra SP, Notario V. The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential. Nature Rev. 2013;13(4):258–71.
38. Xu B, Li J, Liu X, et al. TXNDC5 is a cervical tumor susceptibility gene that stimulates cell migration, vasculogenic mimicry and angiogenesis by down-regulating SERPINF1 and TRAF1 expression. Oncotarget. 2017;8(53):91009–24.
39. Korc M, Friesel RE. The role of fibroblast growth factors in tumor growth. Curr Cancer Drug Targets. 2009;9(5):639–51.
40. Powers CJ, McLeskey SW, Wellstein A. Fibroblast growth factors, their receptors and signaling. Endocr Relat Cancer. 2000;7(3):165–97.
41. Ahmad A, Sakr WA, Rahman KM. Novel targets for detection of cancer and their modulation by chemopreventive natural compounds. Front Bioscience (Elite Ed). 2012;4:410–25.
42. Tanghetti E, Ria R, Dell’Era P, et al. Biological activity of substrate-bound basic fibroblast growth factor (FGF2): recruitment of FGF receptor-1 in endothelial cell adhesion contacts. Oncogene. 2002;21(24):3889–97.
43. Dell’Era P, Coco L, Ronca R, et al. Gene expression profile in fibroblast growth factor 2-transformed endothelial cells. Oncogene. 2002;21(15):2433–40.
44. Hashizume H, Falcon BL, Kuroda T, et al. Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res. 2010;70(6):2213–23.
45. Scharpfenecker M, Fiedler U, Reiss Y, Augustin HG. The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism. J Cell Sci. 2005;118(Pt 4):771–80.
46. Mitsuhashi N, Shimizu H, Ohtsuka M, et al. Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma. Hepatology. 2003;37(5):1105–13.
47. Zeng H, He X, Tuo QH, et al. LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2alpha/Notch3 pathways. Sci Rep. 2016;6:20931.
48. Evdokimova V, Tognon CE, Benatar T, et al. IGFBP7 binds to the IGF-1 receptor and blocks its activation by insulin-like growth factors. Sci Signal. 2012;5(255):ra92.
49. Pen A, Moreno MJ, Durocher Y, et al. Glioblastomasecreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling. Oncogene. 2008;27(54):6834–44.
50. Akiel M, Guo C, Li X, et al. IGFBP7 deletion promotes hepatocellular carcinoma. Cancer Res. 2017;77(15):4014–25.
51. Rupp C, Scherzer M, Rudisch A, et al. IGFBP7, a novel tumor stroma marker, with growth-promoting effects in colon cancer through a paracrine tumor-stroma interaction. Oncogene. 2015;34(7):815–25.
52. Chen D, Yoo BK, Santhekadur PK, et al. Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinoma. Clin Cancer Res. 2011;17(21): 6693–701.
53. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4(6):807–18.
54. Basu P, Maier C, Basu A. Effects of curcumin and its different formulations in preclinical and clinical studies of peripheral neuropathic and postoperative pain: a comprehensive review. Int J Mol Sci. 2021;22(9): 4666.
55. Kabir MT, Rahman MH, Akter R, et al. Potential role of curcumin and its nanoformulations to treat various types of cancers. Biomolecules. 2021;11(3):392.
56. Kurita T, Makino Y. Novel curcumin oral delivery systems. Anticancer Res. 2013;33(7):2807–21.
57. Suganuma M, Okabe S, Sueoka N, et al. Green tea and cancer chemoprevention. Mutat Res. 1999;428(1–2):339–44.
58. Chen Y, Jia D, Wang Q, et al. Promotion of the anticancer activity of curcumin based on a metalpolyphenol networks delivery system. Int J Pharm. 2021;602:120650.
59. Moorthy M, Sundralingam U, Palanisamy UD. Polyphenols as prebiotics in the management of high-fat diet-induced obesity: a systematic review of animal studies. Foods. 2021;10(2):299.
60. Pasinetti GM, Singh R, Westfall S, et al. The role of the gut microbiota in the metabolism of polyphenols as characterized by gnotobiotic mice. J Alzheimers Dis. 2018;63(2):409–21.
61. Singh RK, Chang HW, Yan D, et al. Influence of diet on the gut microbiome and implications for human health. J Transl Med. 2017;15(1):73.
62. McFadden RM, Larmonier CB, Shehab KW, et al. The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflamm Bowel Dis. 2015;21(11):2483–94.
63. Saydam O, Saydam N. Deficiency of Ku induces host cell exploitation in human cancer cells. Front Cell Dev Biol. 2021;9:651818.

domain: health


text:
The agricultural sector is a critical component of any economy, and its productivity has a direct impact on the standard of living of a country’s citizens. It is because of this that governments and policy-makers around the world are always looking for ways to increase agricultural productivity. So, what can be done to increase agricultural productivity? Here are four tips for you to consider.
1. Improve Agricultural Infrastructure
One of the most important things that can be done to increase agricultural productivity is to improve the infrastructure supporting the sector. This includes things like roads, bridges, irrigation systems, and storage facilities. By improving infrastructure, farmers will be able to get their products to markets more quickly and efficiently, and they will have better access to the inputs they need to produce their crops. Also, better infrastructure will help to reduce post-harvest losses, which can be a significant problem in many developing countries.
2. Encourage Research and Development
Research and development are critical for finding new and better ways to increase agricultural productivity. Many agricultural chemical manufacturers, for example, invest heavily in research and development to develop new and more effective pesticides and fertilizers. This is important not only for the company’s bottom line but also for the benefit of farmers who can use these products to increase their yields. A change in a single input can sometimes make a big difference in productivity and profitability.
3. Promote the Use of Technology
Technology can also play a big role in increasing agricultural productivity. Farmers who make use of modern technologies like GPS systems and precision agriculture can increase their yields significantly as this kind of technology can help them to target their inputs more effectively. In addition, by understanding agriculture supply chain crisis challenges and solutions, you can manage the technology to reduce wastage, optimize resources and eventually lead to an increase in productivity. Remember that when you are able to achieve this, you are also playing a role in creating a sustainable food system.
4. Improve Agricultural Extension Services
Extension services play a very important role in agriculture, yet they are often underfunded and understaffed. Extension workers are the link between research institutions and farmers, and they play a vital role in disseminating new information and technologies to those who need them most. It basically involves transferring knowledge from institutions to the farmers, who can practically use it on their farms. When extension services are functioning well, they can be a powerful tool for increasing agricultural productivity.
With the help of these four tips, you can easily increase agricultural productivity in your area. Just remember that it is important to focus on the long-term when trying to increase productivity, as some changes may take time to show results. Also, don’t forget the importance of extension services and technology in this process. If you can keep these things in mind, you should be well on your way to increasing agricultural productivity in your area.

domain: agronomy


text:
Historical reports of important rainstorm and flood events in northwest British Columbia and the Queen Charlotte Islands are compiled for the years 1891-1991. A brief descriptive history is presented for each event, including date, storm duration, precipitation data, storm damage details, and other relevant storm facts, along with a list of the source materials. Storm and flood dates were determined from Environment Canada climatological and streamflow data and local reports (e.g., in newspapers). Storm and flood details were gathered from newspapers, technical reports, scientific publications, ship logs, and diaries. The information is assembled in a chronological catalogue of events. The report will provide land managers, planners, foresters, engineers, and historians with an appreciation for the severity and extent of past historical events and the damage they caused. An understanding of the magnitude and frequency of the events described may help in project planning, emergency plan-ning and risk assessment.
Keywords: Historical reports, rainstorm and flood, northwest British Columbia , Queen Charlotte Islands, descriptive history, storm duration, precipitation data, storm damage details, storm facts, climatological and streamflow data, newspapers, technical reports, scientific publications, ship logs, and diaries, land managers, planners, foresters, engineers, and historians, magnitude and frequency, project planning, emergency planning and risk assessment, forests, natural disturbance
Download Land Management Handbook 31 PDF file (1952 KB)
To view this document you need the current version of
Adobe Acrobat Reader, available free from the
Adobe Web Site.
Updated May 03, 2007

domain: geography


text:
Combine all the ranch ingredients in a mason jar and give it a really good shake. Taste and adjust the seasoning (more salt?) set aside in fridge.
Preheat oven to 450 °F.
In a large bowl using a whisk, combine the flour, paprika, garlic powder, onion powder, salt, pepper and milk, set batter aside.
Remove green sprigs from the base of the cauliflower and discard. Cut the cauliflower in half with a sharp knife and begin removing the florets. and place in a large bowl.
Place florets in large bowl containing batter and coat cauliflower well.
Place a piece of foil on top of baking sheet and grease with Pam Spray or lots of butter. You don’t want the cauliflower sticking to the pan.
Transfer cauliflower to a baking sheet. Make sure to arrange the cauliflower so they are not touching for optimal crispness. Bake for 20 minutes flipping them halfway through.
Meanwhile, in a small bowl, combine the hot sauce, melted butter and maple syrup.
Once cauliflower is cooked for the first 20 minutes, remove the cauliflower from the oven and pour buffalo sauce on each individual cauliflower, and bake for an additional 15 minutes.


text:
Familial Hemophagocytic Lymphohistiocytosis (HLH) is a rare, autosomal recessive, if untreated, fatal disorder of early childhood characterized mainly by persistent fever, hepatocyplenomegaly, cytopenia, hypertriglyceridemia, hyperferritinemia, defective natural killer cell activity and hemophagocytosis in bone marrow, lymph nodes, liver and spleen. Familial HLH is a genetically heterogeneous disease; at least four sub-types (I–IV) associated with three genes and one chromosomal locus (9q21.3-q22) have been reported in the disease to date. A number of mutations in both Perforin and Munc13– 4 genes have been described in different populations whereas only 3 different types of mutations in Syntaxin 11 gene have, thus far, been described in a few families solely from Turkish population. Therefore, elucidation of the mutation spectrum of the Syntaxin 11 gene mostly depends on the identification of its genetic defects in this population. In this communication, we present our findings on Syntaxin 11 gene which is responsible for the familial HLH type IV. A total of 84 potentially primary HLH patients selected on the basis of consanguinity and/or family history and/or relapse were included in the study. Patients and family members were studied by linkage analysis for all 4 described gene loci and homozygosity for Syntaxin 11 gene was observed in 20 patients from consanguineous families. Sequencing of these patients for the complete coding and flanking sequences of Syntaxin 11 gene revealed molecular defects in only 5 patients (2M/3F) with the ages ranging from 2 months to 3 years. Contrary to the heterogeneity in the mutation spectrum of hereditary disorders generally observed in Turkish population, a single type of homozygous mutation (c369–370delAG, c374–376delCGC) was identified in these 5 unrelated patients who had a family history of at least one deceased sibling except one. Screening of the family members revealed that the obligate carriers and some of the siblings were heterozygous for the mutation. This 2 plus 3 nucleotide deletion in exon 2 leads to frameshift and premature termination of translation 59 altered aminoacids downstream (Val124fsX60). Haplotype analysis indicated that these patients who were coming from different parts of Turkey may have a common ancestor (founder effect). Besides confirmation of the “Turkish population endemic” profile of the Syntaxin 11 gene mutations, the findings provided here elucidate the single/common mutation characteristic of the gene which is extremely important in the molecular diagnosis of the disease. This study was supported by TUBITAK (Project No: 105S386; SBAG-3193).
Disclosures: No relevant conflicts of interest to declare.

domain: literature


Apple AirPods are exceptional wireless Bluetooth earbuds, explicitly made for use with Apple products such as the iPhone or MacBook. Though they are not an iOS-only gadget, so you can connect and use AirPods with your Android smartphone, Windows PC, or Chromebook, among several other non-Apple platforms. But here comes the question, “how to connect AirPods to a Chromebook?”
The connecting process may not be as simple as it is with other Apple products initially, but it will be much easier once you understand it.
Your AirPods are capable of assisting you with everything from podcasts and online classes to playing songs while you work. But you must be wondering whether there is a way to connect your AirPods to a Chromebook or not. Well, the answer is yes. You can connect your AirPods to a Chromebook.
Irrespective of the manufacturing company or design of your AirPods, we’ll guide you through how to connect AirPods to a Chromebook and also how to disconnect AirPods from your Chromebook.
Here’s the answer to your question, “how to connect AirPods to Chromebook?”. But first, close any audio or streaming apps on your device before connecting. Being in the middle of a song while AirPods are attached to an Apple device can cause issues while connecting to a Chromebook.
Also to avoid harming your ears while using AirPods with a newly-connected device, start at low volumes and gradually increase the audio level.
The answer to how to connect AirPods to a Chromebook starts with checking the Bluetooth settings. Begin by ensuring that your Chromebook and AirPods are charged and signing into your Chromebook. If you have a Chromebook but recently purchased a pair of AirPods, there is something you should do first.
If you own an Apple device, pair your AirPods with it first. Apple will walk you through the setup process, explain some of the functions, and allow you to name your AirPods. If you’ve never used the AirPods before, here is a fantastic place to start. After that, you may connect them to your Chromebook without having to worry about Apple’s setup.
In the lower right corner of your Chrome OS, select the network symbol. This is located beside the battery level and digital clock. When you click on this icon, you’ll see Wi-Fi, Bluetooth devices, notifications, and more options.
First, ensure that Bluetooth is turned on. To convert between “Off” and “On,” click the little arrow next to the Bluetooth name and icon. If Bluetooth is turned off, switch the slider at the top of the following pop-up from black to blue.
Choose the Bluetooth icon. It will search for any compatible device nearby. Your AirPods will appear by the name you have labeled them.
If your AirPods do not show up automatically, press the button at the back of your Airpods case. This will make your AirPods appear on the Chromebook Bluetooth list shortly.
When Bluetooth is enabled, your Chromebook will begin searching for nearby wireless devices.
Select your AirPods, which should be identified alongside a headphones symbol. Your AirPods will be connected once the pop-up says paired devices. Adjusting the volume on your Chromebook will modify the AirPods audio settings.
A brief confirmation pop-up may be displayed to confirm the connection. It will also mention that you can unpair in Settings. The light on Airpods’s case will turn green once it is connected to your Chromebook.
Yes, you can connect your AirPods to a Chromebook but the results will be different than if they were connected to an Apple device such as an iPhone or MacBook.
There are also some limitations you might face while using your AirPods with a Chromebook. One of which is Siri. You cannot use Siri to manage volume if you are not using an Apple device. However, you can use your Chromebook’s audio outputs or the in-app controls for whichever program you’re using.
A handful of AirPod functions are only available on Apple’s device. You won’t be able to activate and utilize Siri directly from the AirPods, as you can on iOS, and other functionality, including Apple AirPod battery tracking, will be blocked.
If you have AirPods that enable Dolby Digital Spatial Audio, such features will not operate on devices like Chromebooks. Apple is delivering Spatial Audio support to Android devices, but only on select models and with wired headsets rather than AirPods.
Place your AirPods back in the case and close the lid if you’re not using them or want to take a break from listening to music or a podcast. This will charge them as well as disconnect them from your Chromebook.
You may also disconnect AirPods from a Chromebook via the Bluetooth options on your laptop. To disconnect the devices, go to Chromebook Settings and select Bluetooth. Then disable or turn off the Bluetooth connection by switching the toggle from blue to black.
If you no longer want to pair your AirPods with your Chromebook, click the three-dot button next to the name of your AirPods and then click remove from the list.
If your AirPods keep disconnecting from your Chromebook, try the following:
- Disable Bluetooth on your Chromebook and then re-enable it.
- Reconnect the AirPods to the Chromebook.
- Hold down the power button and then turn on your Chromebook to restart it.
- Reset your AirPods.
To reset your AirPods, shut the lid of the AirPods charging case and wait 30 seconds before opening it again.
Next, go to your device’s Bluetooth setups and unpair the AirPods. For roughly 15 seconds, press and hold the Setup button on the back of the AirPods charging case until the LED status light flashes orange.
Connect your AirPods by putting them close to your device and then repeating the pairing process described above. But despite following all the steps above you might sometimes ask yourself why won’t my AirPods connect to my Chromebook.
So, if your AirPods aren’t connecting to the Chromebook, the problem is most likely a faulty connection. Check to see if Bluetooth is on on a nearby iOS device or Mac; if so, the AirPods may not connect to the Chromebook. Also, try restarting your AirPods and reconnecting.
We hope this guide would help you in getting the answer to how to connect AirPods to a Chromebook. Enjoy!


What in the world is super advisor Al Haymon doing? Haymon has never worked well with Bob Arum so you knew that would continue. But there were instances where sanctioning bodies would force Haymon fighters to fight fighters from the Bob Arum stable or even pit Haymon fighters in close fights.
Seems like Haymon has found a loophole through that as well as first it was Quillin dropping his belt instead of facing his mandatory Matt Korobov. Then news broke this week that Danny Garcia and Viktor Postol had reached an agreement not to fight but for Postol to take step aside money, take voluntary fights, and maybe down the line they will fight? Or probably not.
Then Dan Rafael of ESPN wrote a story stating that Roc Nation was interested in bidding on the fight between Bermane Stiverne and Deontay Wilder if it went to purse bid. Not only that but because Wilder is no longer under contract Golden Boy, Roc Nation offered Deontay Wilder 2 million dollars and a five fight deal, which ultimately was declined because Wilder and his team basically said whatever Al says goes.
Rafael of ESPN.com also put this out via his social media pages on twitter and Facebook:
Important language in Haymon’s form contract reads: “During the term of this agreement, Athlete agrees to render services solely and exclusively for Advisor and agrees that he will not take part in or negotiate for any professional boxing contest whatsoever without first obtaining written approval of Advisor.” That is why Quillin and Wilder could not accept deals from Roc Nation. Also, Haymon’s form of contract provides no minimum number of bouts per year and no minimum purse figures.
Incredibly enough when fighters who are advised by Al Haymon say that whatever happens next or fight next and the typical response is, “Whatever my advisor Al Haymon says,” that might hold true as per the contract.
With the Haymon and NBC deal imminent, is there a mass exodus of Haymon fighters fleeing Golden Boy? Seems like it. Rafael also reported that some Golden Boy contracts had a keyhole in the contracts which stated if Schaefer was no longer with Golden Boy, the contracts with Golden Boy would no longer be valid.
So as far as how many of those clients have that type of contract is unknown.
But what is known as Haymon is making his power moves. We all knew it was coming when De La Hoya aligned himself with once hated rival and former promoter Bob Arum, But now it seems like the thawing in that relationship is slowly coming around as the two are making deals and making fights, albeit on the smaller level. Many in the industry believe they will make Cotto-Canelo happen on May 2nd further putting pressure on Haymon and Mayweather to either do something extraordinary or just fall off the date.
What’s more alarming is that Haymon is an advisor/manager to many fighter and in his role he is supposed to work for his clients. In the instances of Wilder and Quillin, they both turned down career high paydays because Haymon said no. Many in the industry believe that Quillin was given 6 figures to drop his belt and was guaranteed a 7 figure guarantee by Haymon for his next fight which could be against new IBF Middleweight Champion Jermain Taylor who is also advised by Haymon. There’s no coincidence as to why Quillin was in Mississippi for the fight between Taylor and Sam Soliman.
As for Wilder, what could possibly get him 2 million dollars and in victory a shot at Wladimir Klitschko? Would he go the WBA “regular” champion route and fight Ruslan Chagaev? Would that entice Klitschko? Or does Haymon not even want to bother putting Wilder in with Klitschko.
Another curious case is Keith Thurman who seemed to be on the rise and somewhere down the line could have been a potential Mayweather opponent. He’s only fought 3 rounds this year and his return could come in November or December against an unworthy foe like a Julio Diaz who he fought early this year. If Thurman also has an agreement as to what Rafael reported, he has no minimum fights a year and can basically be shelved with no consequences.
Because Haymon is an advisor/manager, per the Ali Act he can’t be a promoter. So in the past he’s used Golden Boy as his crutch to get his fighters on. As De La Hoya moved on, he is now using the likes of Lou Dibella and Leon Margules as his crutch and be the promoter on record. Is that the plan moving forward?
How must Stephen Espinoza feel that Kathy Duva told the media that Haymon was going to be competing with HBO and Showtime with his NBC Deal? Showtime has been the main distributer of Haymon fights this year. With Golden Boy poised to work with HBO, where does that leave Showtime who’s had a disappointing 2014 after a great 2013?
A lot of unanswered questions but little by little answers keep creeping out. But we’ll know soon exactly what Al Haymon is plotting, right?


This is steel bobsled roller coaster with banked sharp turns and helices that wrap around the support cylinders. It's suitable for families and not too intense.
Type Bobsled Roller Coaster
File Size 6.69 KB
Date Uploaded Jan 28, 2023
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text:
And I want to address the controversy now before it explodes into an embarrassing scandal: The grass you see in these photos is in fact Liberty, MO grass from the campus of William Jewell College. And from two years ago. Thought I’d fess-up because I’m sure somebody will recognize it and go apoplectic on me. Then the phone starts ringing off the hook and the next thing you know the media are tramping all over my lawn…….
Added a new image to the “Open” series. This is not in Syria or Afghanistan but Hays, Kansas. Not sure if it was hit by a tornado or a wrecking ball. Maybe both… See the rest of the series HERE.
My “wretched” series of photos is growing at a glacial pace; my apologies for keeping you in the blog-o-spere on the edge of your collective seats for so many months! Hope you agree the wait was worthwhile:
When I was a kid I spent probably 90% of my time in the ditch next door to our house building dams out of mud and bricks. It’s what I’d be doing right now if the city hadn’t buried a pipe in place of our creek. So when I got a call this summer about taking photos of the new hydro-electric power plant in Lawrence, I said “Yeah, I’d love to”. Just like that. Very restrained and adult like. Built by Kissick, architecture by Sabatini.


text:
Black Journalists of Modern America: An Oral History
Wallace Terry got the idea to do a book on black journalists while teaching at Howard University. He explains in his Author’s Note why he took on the project: “I picked up an acclaimed book on the history of war correspondents. At first glance, it seemed a perfect selection for a course I was teaching on the role of the foreign correspondent. I was hardly surprised to see that no black correspondents were mentioned, although they had covered World War II, the Korean Conflict, and the Vietnam War. Black journalists were usually missing from historical accounts of war.”
“What stunned me, however, was the story of a British correspondent who claimed that he had rescued the bodies of four white journalists murdered by Viet Cong sappers in the Vietnam War. I knew this story was a lie because I was there, and he wasn’t. In reality, the rescue was made by me and another American correspondent. Why, I asked, was I left unmentioned? Was it because I was black? That’s when I made up my mind to research and write a book about black journalists, beginning with World War II and taking them through the civil rights movement in America and the Vietnam War. This work would help fill the missing pages in the history of modern American journalism.”
Read Wallace Terry Chapter
|Praise for Missing Pages |
“A treasure trove of history. Terry has done all who wish to know the history of this country better˜ a great favor.
Cynthia Tucker - "A Place at the Table" Columbia Journalism Review (May/June 2007)
"A deeply moving, affecting book, truly a bright, shining light."
Walter Anderson - Parade Magazine - Amazon.com
"MISSING PAGES isn't just about the Jackie Robinsons of journalism. It's also about those who reported for black newspapers and risked their lives covering stories in World War II and the Jim Crow South."
Sharon Broussard - "Pioneering Black Journalists Tell of Early Days in History" The Plain Dealer (July 15, 2007)
"Wally Terry offers his own amazing Vietnam War story in the book's final chapter. It makes for riveting reading."
Marc Leepson - "Wally Terry's Last Contribution: A History of Black Journalists" The VVA Veteran (July/August 2007)

domain: history


text:
Duran Duran (album)Duran Duran
is an album by Duran Duran
, originally released on June 8
(see 1981 in music
). It reached No. 3 on the UK charts.
The band's first single to be released was Planet Earth (in March 1981) and it reached #12 on the U.K. charts. This was followed with the release of Careless Memories in May 1981, but it only reached #37. Girls On Film, released in August 1981, reached #5, in part due to the controversy over the video that accompanied it.
All songs written and arranged by Duran Duran.
- Girls on Film
- Planet Earth
- Anyone Out There
- Careless Memories
- Night Boat
- Sound of Thunder
- Friends of Mine
- Tel Aviv
was later rereleased with the extra tracks "Is There Something I Should Know?" (4:08) (the 1983
single) and "To The Shore" (3:48).
Duran Duran are:
- Colin Thurston - producer and engineer

domain: artistic


text:
Baumgartner RN, Koehler KM, Gallagher D, Romero L, Heymsfield SB, Ross RR, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 1998 Apr 15;147(8):755–763.
Evans WJ, Campbell WW. Sarcopenia and age-related changes in body composition and functional capacity. J Nutr 1993 Feb;123(2 Suppl):465–468.
Janssen I, Heymsfield SB, Ross R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 2002 May;50(5):889–896.
Ryall JG, Schertzer JD, Lynch GS. Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness. Biogerontology 2008 Aug;9(4):213–228.
Chevalier S, Gougeon R, Nayar K, Morais JA. Frailty amplifies the effects of aging on protein metabolism: role of protein intake. Am J Clin Nutr 2003 Sep;78(3):422–429.
Kamel HK, Maas D, Duthie EH, Jr. Role of hormones in the pathogenesis and management of sarcopenia. Drugs Aging 2002;19(11):865–877.
Larsson L, Yu F, Hook P, Ramamurthy B, Marx JO, Pircher P. Effects of aging on regulation of muscle contraction at the motor unit, muscle cell, and molecular levels. Int J Sport Nutr Exerc Metab 2001 Dec;11Suppl:S28–S43.
Morais JA, Chevalier S, Gougeon R. Protein turnover and requirements in the healthy and frail elderly. J Nutr Health Aging 2006 Jul;10(4):272–283.
Roth SM, Metter EJ, Ling S, Ferrucci L. Inflammatory factors in age-related muscle wasting. Curr Opin Rheumatol 2006 Nov;18(6):625–630.
Roubenoff R. Catabolism of aging: is it an inflammatory process? Curr Opin Clin Nutr Metab Care 2003 May;6(3):295–299.
Zadik Z, Chalew SA, McCarter RJ, Jr., Meistas M, Kowarski AA. The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J Clin Endocrinol Metab 1985 Mar;60(3):513–516.
Muscaritoli M, Anker SD, Argiles J, Aversa Z, Bauer JM, Biolo G, et al. Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”. Clin Nutr 2010 Apr;29; 1(2):154–159.
Doherty TJ. Invited review: Aging and sarcopenia. J Appl Physiol 2003 Oct;95(4):1717–1727.
Hughes VA, Frontera WR, Wood M, Evans WJ, Dallal GE, Roubenoff R, et al. Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health. J Gerontol A Biol Sci Med Sci 2001 May;56(5):B209–B217.
Wang C, Cunningham G, Dobs A, Iranmanesh A, Matsumoto AM, Snyder PJ, et al. Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. J Clin Endocrinol Metab 2004 May;89(5):2085–2098.
Dobs AS, Nguyen T, Pace C, Roberts CP. Differential effects of oral estrogen versus oral estrogen-androgen replacement therapy on body composition in postmenopausal women. J Clin Endocrinol Metab 2002 Apr;87(4):1509–1516.
Gelfand MM, Wiita B. Androgen and estrogen-androgen hormone replacement therapy: a review of the safety literature, 1941 to 1996. Clin Ther 1997 May;19(3):383–404.
Isidori AM, Giannetta E, Pozza C, Bonifacio V, Isidori A. Androgens, cardiovascular disease and osteoporosis. J Endocrinol Invest 2005;28(10 Suppl):73–79.
Davis SR. The therapeutic use of androgens in women. J Steroid Biochem Mol Biol 1999 Apr;69(1–6):177–184.
Miller KK. Androgen deficiency in women. J Clin Endocrinol Metab 2001 Jun;86(6):2395–2401.
Braunstein GD. Androgen insufficiency in women: summary of critical issues. Fertil Steril 2002 Apr;77Suppl 4:S94–S99.
Slayden SM. Risks of menopausal androgen supplementation. Semin Reprod Endocrinol 1998;16(2):145–152.
Shabsigh R, Katz M, Yan G, Makhsida N. Cardiovascular issues in hypogonadism and testosterone therapy. Am J Cardiol 2005 Dec 26;96(12B):67M–72M.
Kilbourne EJ, Moore WJ, Freedman LP, Nagpal S. Selective androgen receptor modulators for frailty and osteoporosis. Curr Opin Investig Drugs 2007 Oct;8(10):821–829.
Bhasin S, Jasuja R. Selective androgen receptor modulators as function promoting therapies. Curr Opin Clin Nutr Metab Care 2009 May;12(3):232–240.
Schmidt A, Kimmel DB, Bai C, Scafonas A, Rutledge S, Vogel RL, et al. Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology. J Biol Chem 2010 May 28;285(22):17054–17064.
Marcantonio E.E., Witter R.E., Ding Y., Xu Y., Klappenbach J., Wang Y., et al. A 12-Week pharmacokinetic and pharmacodynamic study of two selective androgen receptor modulators (SARMs) in postmenopausal subjects. Endocrine Reviews Supplement 1[31(3)], S872. 2010. Ref Type: Abstract
Fielding RA, LeBrasseur NK, Cuoco A, Bean J, Mizer K, Fiatarone Singh MA. High-velocity resistance training increases skeletal muscle peak power in older women. J Am Geriatr Soc 2002 Apr;50(4):655–662.
Bean JF, Kiely DK, LaRose S, Alian J, Frontera WR. Is stair climb power a clinically relevant measure of leg power impairments in at-risk older adults? Arch Phys Med Rehabil 2007 May;88(5):604–609.
Suzuki T, Bean JF, Fielding RA. Muscle power of the ankle flexors predicts functional performance in community-dwelling older women. J Am Geriatr Soc 2001 Sep;49(9):1161–1167.
Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994 Mar;49(2):M85–M94.
Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 1995 Mar 2;332(9):556–561.
Brach JS, Kriska AM, Newman AB, VanSwearingen JM. A new approach of measuring muscle impairment during a functional task: quadriceps muscle activity recorded during chair stand. J Gerontol A Biol Sci Med Sci 2001 Dec;56(12):M767–M770.
Abellan vK, Rolland Y, Andrieu S, Bauer J, Beauchet O, Bonnefoy M, et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging 2009 Dec;13(10):881–889.
Studenski S, Perera S, Patel K, Rosano C, Faulkner K, Inzitari M, et al. Gait speed and survival in older adults. JAMA 2011 Jan 5;305(1):50–58.
Haley SM, Coster WJ, Andres PL, Ludlow LH, Ni P, Bond TL, et al. Activity outcome measurement for postacute care. Med Care 2004 Jan;42(1 Suppl):I49–I61.
Haley SM, Coster WJ, Andres PL, Kosinski M, Ni P. Score comparability of short forms and computerized adaptive testing: Simulation study with the activity measure for post-acute care. Arch Phys Med Rehabil 2004 Apr;85(4):661–666.
Jette AM, Tao W, Norweg A, Haley S. Interpreting rehabilitation outcome measurements 1. J Rehabil Med 2007 Oct;39(8):585–590.
Sharkey JR. Diet and health outcomes in vulnerable populations. Ann N Y Acad Sci 2008;1136:210–217.
Dillon EL, Sheffield-Moore M, Paddon-Jones D, Gilkison C, Sanford AP, Casperson SL, et al. Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-I expression in older women. J Clin Endocrinol Metab 2009 May;94(5):1630–1637.
Paddon-Jones D, Sheffield-Moore M, Urban RJ, Sanford AP, Aarsland A, Wolfe RR, et al. Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest. J Clin Endocrinol Metab 2004 Sep;89(9):4351–4358.
Parise G, Yarasheski KE. The utility of resistance exercise training and amino acid supplementation for reversing age-associated decrements in muscle protein mass and function. Curr Opin Clin Nutr Metab Care 2000 Nov;3(6):489–495.
Solerte SB, Gazzaruso C, Schifino N, Locatelli E, Destro T, Ceresini G, et al. Metabolic effects of orally administered amino acid mixture in elderly subjects with poorly controlled type 2 diabetes mellitus. Am J Cardiol 2004 Apr 22;93(8A):23A–29A.
Janssen HC, Samson MM, Verhaar HJ. Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr 2002 Apr;75(4):611–615.
Parfitt AM, Gallagher JC, Heaney RP, Johnston CC, Neer R, Whedon GD. Vitamin D and bone health in the elderly. Am J Clin Nutr 1982 Nov;36(5 Suppl):1014–1031.
Sato Y, Iwamoto J, Kanoko T, Satoh K. Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial. Cerebrovasc Dis 2005;20(3):187–192.
Holick MF. Optimal vitamin D status for the prevention and treatment of osteoporosis. Drugs Aging 2007;24(12):1017–1029.


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The Governor of Bauchi State, Bala Mohammed has shared his experiences while in isolation for the coronavirus (COVID-19) infection.
The Governor while addressing journalists at government house Bauchi, lamented that he went through ‘hell’ during the three weeks he spent in isolation.
While thanking those who reached out to him during the period and his loved one for standing by him, Mohammed noted that his stay in isolation has changed his life forever.
“This disease that I was infected with is a terrible experience. I went through hell while in isolation for treatment, I felt like I was alone but the love, affection and prayers shown to me by the people of Bauchi State really kept me going,” he said.
“I thank Allah that I have now been freed from the virus. I am sorry for the inconveniences it might have caused to anybody in Bauchi and Nigeria, it has never been my wishes to be infected.
“I have received best wishes and prayers from many people across the divide, some of whom I do not even know.
“This show of love has strengthened my spirit to work hard and deliver dividends of democracy to the people of Bauchi State, and I can assure the people of Bauchi State that I will do exactly that.”
Naija News recalls the governor was discharged on Thursday but was in the news again on Friday for ignoring social distancing at at a crowded Jumat service.
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domain: politics


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Most approaches to improve on short interfering RNAs (siRNAs) have focused on the ribose moiety of nucleotides. A largely unexplored but potentially significant route to modulate siRNA properties is the base itself, suggested Peter A. Beal, Ph.D., professor of chemistry, University of California-Davis.
“Modifying nucleobases within a sequence can exert profound effects on the chemical, biological, and physical properties and interactions of oligonucleotides. Immune stimulation mediated by RNA oligonucleotides harboring certain sequence motifs, such as GU-rich regions, is a significant hurdle to the development of safe and effective RNAi therapeutics.
“We addressed this challenge in a series of studies in which we employed novel nucleobases in an oligonucleotide mimic of microRNA-122 (miR-122). Because it is already known that modification of the ribose 2´-position can reduce immunostimulation, we constructed our study to also include these modifications for comparison.”
Dr. Beal and colleagues utilized analogues of adenosine and guanosine that contained cyclopentyl and propyl minor-groove projections. “siRNAs have an A-form helix structure that contains both a major groove and so-called minor groove. The latter is the site of binding for many RNA-interacting proteins. We synthesized guanosine analogs with base modifications that affected the minor groove. Further, we substituted these analogs at different positions within reported immunostimulatory motifs. To test for RNAi activity, we measured the knockdown of two native miR-122 targets (Necap2 and Slc7a1).”
The results were unanticipated. “To our surprise, we found single nucleotide positions throughout the guide strand of an miRNA-122 mimic acted as immunostimulatory hot spots of activity that did not correspond with putative motifs (e.g., GU-rich regions). We believe these hot spots are locations where RNA and Toll-like receptors interact. Thus, modification of nucleobases at specific positions can control immunostimulatory properties of siRNAs in ways not predicted with traditional immunostimulatory motifs.”
Successful RNAi-mediated knock-down requires efficient delivery of the payload. Traditional methods (e.g., lipid-based reagents) may not work well for certain cell types such as neurons and hematopoietic cells. Viral vectors offer an alternative system for delivery.
“Viral biology can be engineered to deliver genetic material into cells very effectively and modulate gene expression for both short- and long-term functional studies,” explained Devin Leake, Ph.D., global director of R&D genomics, Thermo Fisher Scientific.
According to Dr. Leake, a viral vector system needs to address three key parameters. “It must be able to effectively deliver genomic content, have a very broad tropism, and allow for the long-term expression of that content. This requires the careful design of the short hairpin RNA (shRNA), the vector backbone, and choosing the best promoter for the particular cell type utilized.”
In creating the Thermo Scientific SMARTvector2.0® Lentiviral shRNA platform, the company designed a microRNA-adapted expression scaffold to maximize accurate processing of the silencing sequence while minimizing the potential for off-target effects.
“We rigorously tested a panel of miRNAs and selected one that could consistently and efficiently be processed by the endogenous RNAi-silencing machinery. It is also necessary to have rationally designed highly functional gene targeting sequences. The SMARTvector2.0 algorithm selects optimal shRNA targeting sequences and includes seed-based filters to reduce toxicity.”
Another important feature of a lentiviral vector system is the promoter. Although the company initially included the promoter from cytomegalovirus (CMV), it will soon be releasing an a-la-carte series of promoters that investigators may choose.
“The CMV promoter may be too weak in some cell types. There is no universally optimal promoter, so we have developed a series of SMARTvector backbones with the option of seven different promoters, called the Thermo Scientific SMARTchoice system, which will provide researchers with greater flexibility and more choices for successful RNAi experiments.”
Thermo Fisher Scientific custom-builds the lentiviral system using the requested promoter and the appropriate sequence for the client’s target of interest. It plans to release the system in the first quarter of 2012.
RSV miRNA Tactics
Respiratory syncytial virus (RSV) infects many children by the age of 2 and causes >100,000 hospitalizations each year in the U.S. It also strikes the elderly resulting in more than 14,000 deaths. Currently there is no safe and effective vaccine against RSV. Further, antiviral drugs are limited. Clinical trials are currently being conducted using RNAi therapeutically against RSV. Additionally use of a humanized mAb (palivizumab) against another RSV protein provides an option for treating infants at risk.
Ralph A. Tripp, Ph.D., Georgia Research Alliance chair and professor of infectious diseases, is investigating how RSV modulates human miRNAs. “Studies are showing that many viruses like RSV dysregulate host miRNAs to alter host defenses, and that this process can be attributed to specific virally encoded proteins that assist infectious processes. Because single miRNAs are predicted to regulate multiple genes and affect hundreds of processes, a goal of my lab is to determine how RSV infection influences global gene expression in respiratory epithelial cells.”
Dr. Tripp’s group infected cultured cells with RSV and RSV mutant viruses deficient in single genes and utilized miRNA reporter assays to assess cellular dysfunctions. Next they employed computational algorithms to predict miRNA target genes and found and validated sets of genes targeted by the miRNAs.
“Our studies demonstrated that in epithelial cells, RSV infection induced five specific miRNAs and repressed two. The RSV-specific proteins modulated miRNAs that affected cell cycle and chemokine genes, and suppressed cytokine signaling genes that control antiviral cytokine responses.”
These findings may translate into improved therapeutics eventually. “We’ve spent over 35 years trying to produce a vaccine against RSV. Now that we better understand how it controls host immune responses, we have the opportunity to create a new vaccine using miRNAs to create a more robust immune response to RSV. Additionally, development of miRNA agonists or inhibitors could also be envisioned for inhibiting an active RSV infection. Understanding the mechanisms used by RSV to control the host’s response to infection will allow us to develop improved intervention strategies that are safe and effective.”

domain: medical


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Norway shooting suspect thought to be Islamist with mental health issues – police
OSLO — The arrested suspected in a fatal shooting spree in Oslo is believed to be a radicalized Islamist who has a history of mental illness, Norway’s PST intelligence service said on Saturday.
The suspect, who was not named by police, has been known to security services since 2015, the PST added.
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A national bookmaker has assured customers it has “no current plans” to close any more stores in the city.
Ladbrokes on Dura Street closed its doors for “trading reasons” recently.
A number of customers said they were shocked to hear the branch had shut its doors for the final time.
Locals in Stobswell still have access to a Ladbrokes on Albert Street but there were fears more closures were set to follow.
A spokesman for Ladbrokes said the Dura Street closure had resulted in two redundancies while other staff were moved to other premises.
He added: “The shop concerned was closed for trading reasons as it was no longer commercially viable.
“We sought to redeploy colleagues in surrounding shops but there were two redundancies relating to the closure.
“There are no current plans to close other shops in the area.”

domain: economics


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Friday, May 19, 2006
A Thoughtful Day
I'm really angry with myself tonight. Not over anything I've done, but the fact that I allowed the actions of someone else to hurt my feelings. How childish is that! This will be a weekend of putting things into perspective.
This quilt was made for me at the Alex Anderson Retreat 2004 and signed by all the retreaters. I had to cancel my plans at the last minute because my shoulder surgery date was moved. Marlene spearheaded the project, Holly made the label, and Deb and I think even Alex worked on the binding. It was quilted at the retreat by the APQS rep who was there demonstrating long-arms. What joy to get this in the mail a week or so after retreat! And what wonderful friends I have made through the years at the retreat! I can't wait until this November to see them all again!
I have been invited to a sew-in tomorrow. It'll be good to be with other quilters. I think I'm going to work on my orange/yellow/pink string quilt. I've never made one before but have admired them for a long time. It should be a fun day.


|Smith & Wesson Folding Knife with Tactical Pen|
The SPREAD GOOD CHEER event is on at Public Safety Stores! The 2012 Gift Ideas have been:
- Sparta Pewter Keychains for Police, Fire and EMS
Today's Gift Idea : Smith & Wesson Folding Knife with Tactical Pen. It has:
- SW 423B black titanium coated folding knife
- 3.2" standard stainless steel blade
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- 4.3" black titanium coated stainless steel handles with liner lock safety
- 5.7" SW black tactical pen with replaceable Hauser cartridge
For less than $29 each.
The goal is to help you "Give back to those who give all year!"


Price: 0.0009758 BTC
* Product Type: Keyboard Coiled Cable
* Color: Rainbow / Pink&Blue / Black / White / Red / Purple
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* Interface Port: Type-C to USB
* Cable Length: 2.2m
1. Gold plating plug shell, high quality
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As today’s devastating Brexit defeat for Theresa May in the British Parliament proves, fact can be as much of a drama as fiction.
In fact, it is reality of sorts that makes up most of the cream of the small screen crop for the latest the show to watch this week. For instance, there is the January 19 debuting Benedict Cumberbatch starring Brexit movie on HBO about the man behind the campaign that has brought political chaos to the UK.
The same day, BBC America hosts the premiere of the endangered animal kingdom-based Dynasties while on January 20, Don Cheadle returns to Showtime with the 1987 set comedy Black Monday. In pure Marvel mode, Jon Berthnal led The Punisher returns for a second bloody season on Netflix on January 18.
You’ll have to check out the video above to see exactly which one of the four shows is the one you have to watch this week.
Having already played on the other side of the pond last week, the Toby Haynes directed and James Graham penned Brexit may be a bit too frothy in part, but it is literally timeliness personified. Also starring Cumberbatch’s fellow The Imitation Game alum Rory Kinnear as well as The Crown’s Oliver Maltman, the premium cabler movie probes into the mind and methods of Vote Leave strategist Dominic Cummings, played with full eccentricity and follicle challenges by the Emmy winning Sherlock actor.
As one of only two Marvel series now on Netflix following the cancelations of Iron Fist, Luke Cage and Daredevil and launching the same day as Season 5 of Grace & Frankie, The Punisher has its finger relentless on the trigger for its second season. Even with a now scarred Ben Barnes back and new additions in the forms of Giorgia Whigham as a mysterious teen sidekick of sorts for the ex-Walking Dead actor’s often ruthless Frank Castle, L.A. Law and American Gods’ Corbin Bersen and a fundamentally cold new villain in Josh Stewart, the sheer vigilantism and body count never wavers.
Wavering is the ability of several species to survive, as the perpetually passionate David Attenborough hosted Dynasties makes very clear in its five-part series that starts on Saturday. The exquisitely depicted BBC Studios Natural History Unit production, co-produced with BBC America, Tencent Penguin Pictures, CCTV9 and France Télévisions will mark a big leap for BBC America as it simulcasts with AMC, IFC and Sundance TV for each episode.
A big leap or fall is but one of many moves in the Seth Rogen and Evan Goldberg executive produced Showtime series Black Money featuring House of Lies lead Don Cheadle back on the premium cabler. Having already previewed the pilot online, the Jordan Cahan and David Caspe created comedy aims to reveal the supposed real reason behind the sudden and harsh Wall Street crash of October 19, 1987. In that effort, Black Monday takes a number of leaps of faith, financial and otherwise with Avengers alum and Oscar nominee Cheadle as the Lamborghini limousine riding head of a rogue trading firm and Regina Hall and Book of Mormon star Drew Rannells as his high funded lieutenants.
So, place your bets and click on the video above to see who is the show you just can’t miss this week – and that’s a fact.
Subscribe to Deadline Breaking News Alerts and keep your inbox happy.


text:
Teveel bedrijven om op de kaart weer te geven. Verfijn de zoekopdracht.
Dutch Tec Source BV (DTS) is a machine manufacturer that has specialized itself in particular in building screw- blanchers, coolers and cookers for a.o. potato flakes and french fry productions lines
Dale and Thomas gourmet snacks go beyond chocolate popcorn and cheese popcorn. Some of their customer favorites include peanut butter popcorn, caramel popcorn and world-famous kettle corn popcorn.
The Daly’s have been growing potatoes on the pristine South-East Coast of Tasmania for over 30 years. Overlooking Marion Bay, the farm enjoys perfect conditions – sandy soils, rain, and sunshine.


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Twelve Bar Collection
The Art of Chocolate Twelve Bar Full Collection is curated with one bar from each of the core COCO range. This is the ultimate gift, a real luxurious chocolate treat.
Each bar is hand-crafted and wrapped in original, unique and contemporary designs. Our chocolate is both ethically sourced and sustainable.


Sandvik HX900 cast-in carbide is a unique wear material that combines the wear resistance of cemented carbide with the shock resistance, malleability and forming capability of nodular cast iron. This ideal combination provides a wear-resistant material that withstands tough environments and has a long wear life in many extreme applications.
Hard, durable and flexible
HX900 has a wear resistance that is comparable with cemented carbide and a strength that is 80–90% of the strength of pure nodular iron. This makes HX900 a unique, high-performing wear protection material for applications with high abrasive wear as well as for applications with heavy impact, or a combination of both.


text:
Book us now for India Driver Tours and make traveling a pleasurable affair. We are dedicated to being the #1 Source for your whole transportation wants. It takes just one journey for you to experience the way in which all private transportation must be. Want to see St. Louis like a St. Louisian see’s it ? Call to e-book a tour of the town and we show you St. Louis like it was meant to be seen from the large points of interest to the most effective kept secrets and techniques. If your journey wants require a protected, private, and discreet driver tell us and will deal with your whole transportation needs.
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While I actually have made the booking types to only take a deposit, with the remaining amount payable in cash to the motive force, I’m considering this makes issues complicated. I think I would want personal cab+ driver only for Day 2 & Day four. The in a single day fee is IDR 300k, which incorporates the driver’s lodging and meals. That method you possibly can e-book a driver for a number of days and keep anyplace in Bali.
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Maybe he’s already headed in direction of where he thought you wanted to go and turning around now takes another 30 minutes. They will await you when you are there — that’s not a problem — however the secret is communication. No sweat, simply text your driver that you will be staying a bit longer.
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Even higher than an e-mail, I’ve made a booking kind particularly for transfers from South Bali to Lovina – and one other for transfers from Lovina to South Bali. Hi Michael, I would love a driver to drive from Seminak to Lovina after which three days later Lovina to Legian.
You discovered 15 private driver web site templates from $12. All created by our Global Community of impartial Web Designers and Developers. After lunch Massi will drive you into the center of Siena, he will give you a brief tour in the van of the top sights together with the main Piazza called Piazza del Campo in addition to our beautiful Duomo. Then you will have 1 hour of free time to explore the town store or take photographs. Not only can we get you from one part of Tuscany to another, we will craft your custom transfer to incorporate wine tastings, city excursions and other fun locations along your route. Some drivers include as much as 10 hours in their every day fee. I actually have a really trustworthy driver that I use regularly.
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Just tell your driver firstly of the journey so he can plan on getting you there in time, and be mindful if you go over 10 hours or half thereof to pay the additional IDR100k per hour in cash. You can e-book a driver for the day on-line for tomorrow if you e-book in the next hour. I’m in bali now and we want to e-book a driver with you for this sunday the fifteenth if possible.


Asus 8Z India launch confirmed FINALLY! No signs of ZenFone 8 Flip though
Asus 8Z has been confirmed to launch in India on February 28. The Asus 8Z was the company's 2021 flagship.
Asus 8Z is coming to India FINALLY! One of the most awaited Android phones of 2021 is making its way to India after almost a year. Asus had originally wanted to launch the Asus ZenFone 8 Flip under the Asus 8Z series in India around April 2021 but the COVID-19 second wave saw the company out it on hold at the time. Asus never revealed the reasons why the launch was delayed but the 8Z is finally making it to our markets. Asus is yet to speak about the Asus 8Z Flip, the proper Asus flagship that features the Flip Camera arrangement.
The Asus 8Z will be announced via a livestream event on February 28 at 12 pm on YouTube. The teasers only show the Asus 8Z, which is the more conventional variant of the Asus ZenFone 8 Flip. Asus is yet to hint at the prices of the Asus 8Z. Given that the phone is based on the Snapdragon 888 platform, we expect the phone to be presented as the rival to the likes of the Xiaomi 11T Pro, Realme GT, and iQOO 9.
Asus 8Z launching soon in India
The Asus 8Z is expected to be a renamed version of the Asus ZenFone 8 from last year. That means we can expect the phone to have the same Snapdragon 888 chip underneath. Buyers can spec it up internationally with up to 16GB of RAM and 256GB of internal storage, although India could get the reserved 8GB variants to keep the prices low.
The Asus 8Z will also get the same 5.92-inch Full HD+ AMOLED display with a 20:9 aspect ratio. The display has a Gorilla Glass Victus protection and a refresh rate of 120Hz, peak brightness of 1100 nits and a 240Hz touch sampling rate.
The ZenFone 8 drew attention for its smaller 4000mAh battery with 30W fast charging support and it remains to be seen how it holds up in the real world. At it launch, it ran on Android 11-based ZenUI 8 but Asus could launch it with Android 12 in India.
Lastly, for the cameras, the Asus 8Z will have a 64MP Sony IMX686 primary camera sensor with OIS and a 12MP ultrawide camera, which can also take macro photos. With no Flip Camera arrangement, the front 12MP camera sits in the hole-punch cutout.
Other miscellaneous features includes an IP68 certification for water and dust resistance, 3.5mm headphone jack, Wi-Fi 6E, Bluetooth 5.2, and more.
Catch all the Latest Tech News, Mobile News, Laptop News, Gaming news, Wearables News , How To News, also keep up with us on Whatsapp channel,Twitter, Facebook, Google News, and Instagram. For our latest videos, subscribe to our YouTube channel.


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Super Mario Odyssey has given Switch the sales boost it needed to pass the two million consoles sold marker in its native Japan.
Last week, Switch sold 133,094 units, with the bulk of that figure apparently thanks to the Super Mario Odyssey Switch bundle. Last week also marked the biggest delivery of Switch stock Nintendo had issued to retailers in the last four months, meaning there were more consoles on offer than normal.
According to Famitsu, Super Mario Odyssey sold 511,625 copies during its first three days on sale in Japan. These sales include game-specific download cards and the Switch Super Mario Odyssey bundle, but not copies purchased directly from the Switch eShop.
It would appear that the entire shipment of physical copies sold during the first three days on sale, so the total figure could well have been even higher.

domain: hobby


text:
We spotted Laneia on the map, had heard good things about it, and decided to go see for ourselves. We turned off the main road onto a road that got smaller and smaller...and smaller...as we drove into town. Laneia is not for faint hearted drivers. The road is barely larger than a single car in some spots and once you 'commit' to going into town, there's no turning back. Fortunately for me, it was quite quiet and I made it through without damaging the car.
We parked in a lot lined with amazing flowers.
Check them out close up - spectacular.
We explored a few quaint, cobbled alleys, before heading back to the car for our journey back to Lemesos.
Along the highway just outside town, we made a detour into Katerina where they made and sell a variety of sweets.
Samples of candied 'spoon fruit' were on offer.


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text:
I worked with her at the Orlando Sentinel several years ago.
President Donald Trump is "absolutely" planning to sign a resolution condemning hate groups, the White House said Wednesday, after both the Senate and the House passed a resolution in the wake of a white nationalist rally in Charlottesville, Virginia. "We have addressed this with Jemele and she recognizes her actions were inappropriate", the ESPN statement said.
That really isn't surprising as they are a business and having their employee bash the president may be bad for business (though with Trump's approval rating so low, it might actually be good to support Hill).
"Trump is the most ignorant, offensive president of my lifetime".
And what's even worse is Hill is pretty much painting anybody who voted for Trump as a white supremacist.
Others criticized Kaepernick for supporting Hill. As part of the protest, Kaepernick chose not to stand during the national anthem last season.
"I'm not going to speak for that individual, but I know that the president has met, again, with people like Sen". While Hill is taking the brunt of the backlash, ESPN is walking the tightrope of racism, sports and politics, and the network is deciding when boundaries have been pushed.
"Sports have always been political", she said.
Hill was on ESPN's SC6 as normal Tuesday.
ESPN fired baseball analyst Curt Schilling, who has strong conservative opinions, in 2016 for a Facebook post about transgender people. The bill would have required transgender persons to use public restrooms that corresponded to the sex they were assigned at birth. Glad you could live with voting for him. I wouldn't go so far as to say that her response was full-on authoritarianism, but - as with so many things in the Trump administration - it's skirting dangerously close. Now you need laws telling us differently?


text:
Historic Maps and Views of New York is a unique and fascinating collection of twenty-four New York maps and views dating from the 1600s through the present. Included with each map is the original printing information and brief text that places it in historic context and further illuminates its qualities.
Put together by a map expert based at the Library of Congress, the selections include one of the earliest maps of Manhattan by Johannes Vingboons; views of New York Harbor in the early 1700s; an elaborately detailed map of Central Park; a complete topographical map of the island of Manhattan; an early subway map; overviews of Brooklyn and Queens; and much more. Each unique and stunning representation of New York is exquisitely reproduced to show off its color and detail, making it ready for display in any home, office, dorm room, or classroom.
- 56 pages
- 11.25 x 0.5 x 14.25 inches
- by Vincent Virga