text:
Bollywood couple Ali Fazal and Richa Chadha wedding has been one of the most awaited events of the industry. After dating for a long time now, the couple is all set to tie the knot in the first week of October 2022. Reportedly, the couple's wedding ceremony will be held at a South Mumbai hotel. With just a few days left to their wedding, the couple has been sending out invites. The picture of the same is going viral on social media platforms which is being loved by not just fans but also their Bollywood friends.
The actor duo got a friend to design their wedding save the date who custom sketched their faces into kitschy pop art design. The invite has a retro 90s feel made in a shape of a matchbox that reads- "Couple Matches" with a quirky sketch of Richa and Ali in a traditional garba outfit both riding a bicycle.
The picture was also shared by the paparazzo group on Instagram on Wednesday. Several fans reacted to the post including veteran actress Shabana Azmi. She commented, "It’s such a lovely card." A fan said, "It's so perfect." A user also wrote, "We love ittt."
Ali and Richa's wedding preparations are in full swing. According to a recent update, the bride-to-be's jewellery will be customised by a 175-old jeweller family from Bikaner. According to IANS, Richa Chadha's wedding jewellery will be made by the Khajanchi, who is a revered family of jewellers known for their statement heirloom pieces. They will be designing signature pieces for the bride. They are descendants of Moti Chand Khajanchi, one of the earliest art collectors in Rajasthan and the patrons of their jewelry include the royal family of Bikaner.
Richa Chadha-Ali Fazal's pre-wedding festivities
One of the places where the couple's pre-wedding celebrations will be taking place is one India’s oldest club. Established in 1913, the club is one of the country’s oldest and most exclusive venues in the National Capital, the Delhi Gymkhana Club. The venue will host one of the ceremonies. It is said to have a wait list of almost 37 years for membership. The couple will have their wedding festivities begin by end of September and will conclude in Mumbai in the first week of October. For the unversed, Richa and Ali first met on the sets of Fukrey in 2012 and soon fell in love. After dating for seven years, Ali proposed to Richa in 2019, and the couple was to get married in 2020.
Meanwhile, for the marriage, Richa will fly down to Delhi on September 27, and Ali will join her shortly after, in order to complete all the prep for their wedding celebrations as the festivities will start in Delhi first.


text:
Donald Trump surrogate Rudy Giuliani tried to deflect criticism of Trump’s claim that the presidential election could be “rigged” by claiming that the GOP nominee had actually been “talking about the unfair media coverage that Republicans get.” In fact, Trump has specifically said that he was referring to the myth that the absence of voter ID laws would lead to widespread voter fraud. In reality, in-person voter fraud is extremely rare. From the August 7 edition of ABC’s This Week:
MARTHA RADDATZ (HOST): Donald Trump has been raising questions about whether this election could be rigged. You've lost elections in the past and never really said anything like that. Is that an appropriate thing for him to be saying? Do you believe this election could be rigged?
RUDY GIULIANI: I think what he's talking about is the very unfair media coverage that Republicans get. I know all of those -- of you in the media don't believe this, but you really don't treat us the same way. The allegations by Mrs. Smith, a Gold Star mother about Hillary Clinton lying to her got about one-tenth of the coverage that the Khan situation got. Hillary's situation in which the FBI in an extraordinary memo found her to be extremely careless in handling top security information. My goodness, I wouldn't hire a person as an assistant U.S. Attorney if that was in their FBI background. We're going to make her president of the United States? Nobody raises that. Nobody makes a very big deal about that. That's not on the news for five days, six days. So I think what Donald Trump is reflecting is and know the media always discounts this, because you don't like to get criticized, but you don't treat us the same way that you treat Democrats.

domain: politics


text:
Sony and Will Smith‘s Overbrook Entertainment have hired screenwriting team Jeremiah Friedman and Nick Palmer to write Karate Kid 2, which now has an empty director’s chair as Breck Eisner has exited due to a scheduling conflict with his Vin Diesel pic The Last Witchhunter. The scribes follow Ethan Reiff and Cyrus Voris and Zak Penn, who previously had been tapped to write the sequel. Friedman and Palmer’s action comedy script Family Getaway made the 2010 Black List, and the pair was subsequently hired to script the Bodyguard remake for Warner Bros-based Lin Pictures. They earned more press in 2012 when they sold their Die Hard-esque pitch Speeding Bullet to Universal in a mid-six-figure deal. Sony’s Karate Kid sequel will return stars Jackie Chan and Jaden Smith for more martial arts action in the studio’s blockbuster franchise reboot. Harald Zwart directed the 2010 Karate Kid, which scored $343 million worldwide with a contemporary China-set take on the crane-kicking 1980s original.
Breck Eisner Out For ‘Karate Kid 2′ As Sony, Overbrook Hire New Scripting Duo
What's Hot on Deadline
More From Yamato
- Aaron Sorkin Still In Bed With John Edwards Exposé 'The Politician'
- 'American Sniper' Trailer: Bradley Cooper At His Best?
- Jim Carrey, 'Dumb And Dumber To' Producers Eye Reteam On 'Deep Cover'
- 'The Interview' Yanked By Regal, AMC & Other Major Chains
- Through a Lens Darkly

domain: entertainment


The average carpet is replaced every twelve years, even though it begins to show signs of poor care after only three to five years. The carpet industry refers to this as “Uglying Out”, note they don’t call it “Wearing Out”. This condition typically affects high traffic areas and in the front of furniture first, causing them to look dull and soiled. Today’s lighter colored carpets require regular professional care to keep them looking great until they truly wear out.
So Why Do They “Ugly Out” Before They “Wear Out”?
New carpets are coated with a protective fiber coating from the factory. This is what keeps spills from staining your carpet and makes vacuuming a much easier and effective task. Over time foot traffic causes soil to become ground in and trapped in your carpets fibers. To the naked eye dirt has a smooth look to it, but under a microscope you will find it has sharp, jagged edges causing it to be abrasive. The soil acts like tiny saws, cutting into the protective coating exposing your carpet fibers to damage. Now exposed, soil and spills can penetrate deep into your carpet fibers causing it to “Ugly Out” faster. Even worse, your carpet is now exposed to possible permanent staining leading to it “Wearing Out”.
The Solution—Renew Your Protection
Renewing carpet protection after each cleaning reinforces your carpets original factory protectant. Spills will become easier to remove, vacuuming will be more effective and most important your carpet will look better for much longer. That’s why most carpet manufacturers recommend renewing your protection after each cleaning. Live Cleaner with a cleaning from Safe-Dry Carpet Cleaning of Birmingham.
Tags: Carpet Cleaning, Rug Cleaning, Upholstery Cleaning, Pet Odor Removal, Safe Cleaning, Dry Cleaning, Green Cleaning


Rep. Darrell Issa said Sunday that Lois Lerner’s attorney has “outright lied” a number of times while defending the former head of the IRS tax-exempt division.
“Her attorney has said things that are not correct, or disingenuous or outright lied a number of times, it's been shown by email,” the House Oversight and Government Reform Committee chairman said on CNN’s “State of the Union.”
Lerner’s attorney, William Taylor III, has said that Lerner did not deliberately crash her hard drive in 2011, causing emails to be lost, and did not print her emails to paper as Issa asserts.
Issa said Taylor is “trying to get his client off the hook after flubbing and taking the Fifth.”
“Ultimately, what we know is the archivist said that the IRS failed to do what they were supposed to do with informing, failed to properly keep documents, and that has very little to do with the fundamental problem, which is [that] Lois Lerner's unit, headed by Lois Lerner and directed by Lois Lerner, unfairly targeted and abused conservative groups for what they believed,” Issa said.


text:
Submitted by Anonymous (not verified) on Tue, 05/29/2012 - 20:40
Product you want to review:
Where did you find out about Springfree?:
This is one awesome trampoline! Trick to install though - pull the white rods from underneath the matt, and have someone from the top click them into place. I (5'4" female, slight bulid) built this with the help of my 10 year old!

domain: hobby


text:
Sun, 16 February 2020
The gang discusses two papers about unique fossil preservation. One paper looks at how fossil root systems can inform our understanding of early Devonian forests, and the other paper shows how slime molds can be preserved in the fossil record. Meanwhile, Amanda is excited for questionable reasons, James prepares for the pain, and Curt learns his role in the friendship.
Up-Goer Five (Amanda Edition):
Today our friends talk about weird cool things that have only one piece but can get very big, and the tall green things with many pieces above and under ground, that is trees. Because trees is a word we can use. We focus on the pieces under ground. The weird cool things that have only one piece are found in old tree blood. The part of the weird cool things that have only one piece look kind of like things that are good to eat but might also kill you that grow on the ground. They are where the weird cool things that have only one piece make more of themselves. They are very very old but look just like pieces around today. The paper says maybe this is a sign that things stay the same for a very long time because the world around things makes it so, but it is important to remember that sometimes two things that are not close brothers and sisters can look very very much like close brothers and sisters. The tree paper finds very very old tree parts under ground and says that groups of trees a very very long time ago were even more like groups of trees today than maybe we thought. This would make the ground safer for things to live on.
Stein, William E., et al. "Mid-Devonian Archaeopteris Roots Signal Revolutionary Change in Earliest Fossil Forests." Current Biology (2019).
Rikkinen, Jouko, David A. Grimaldi, and Alexander R. Schmidt. "Morphological stasis in the first myxomycete from the Mesozoic, and the likely role of cryptobiosis." Scientific Reports 9.1 (2019): 1-8.
Direct download: Podcast_181_-_Before_the_Pain_The_Root_of_the_Problem.mp3
Category:general -- posted at: 3:00am EST
Sun, 2 February 2020
The gang returns back from their winter break to discuss two papers that look at the important information we can glean from soft-bodied organisms in the fossil record. First, we take a look at a paper that shows some incredible preservation of Cretaceous snails in amber and how we can use that exceptionally preserved material to infer important information about the evolutionary history of these groups. Second, we talk about a cool example where hypotheses pulled from trace fossils can inform the distribution of modern worm species. Meanwhile, Amanda was not content with being driven mad by just TWO cats, James somehow manages to complain about being good at things, Curt spills the secrets on his friends, the internet TOTALLY doesn’t mess up our recording, SpaceX should probably paint their satellites, and we completely stay on topic this entire time….. believe me…..
Up-Goer Five (Curt Edition)
The friends talk about two papers about things that have soft bodies. First, the friends talk about a paper where a soft animal who makes a hard home out of rock that it carries around with it was stuck in some stuff that comes off of trees. This stuff that comes off of trees made it so that things we usually do not see got saved in the rocks. This allows us to see all of these different soft things that don't show up in rocks. People used these bits of tree stuff with soft things in them to find out that some of the soft things we see today in these animals that make a home for themselves out of rock may have first showed up very very long ago. They use this to try to find out when these groups of animals may have first showed up.
Next, our friends look at the changes in broken up bits of rock that form from soft and long animals live in the ground. As these animals move through the ground, they leave behind remains of where they were that can be seen in the broken up bits of rock they live in. These remains are usually very much the same when they are made by soft and long animals which live in very much the same way. One type of remain is usually found in places that are cold, but some people think they have found some of these remains in places that are usually pretty hot. This might be because there are ways that water moves which can cause areas that are usually very hot to have very cold water in them. That might make it just right for these soft and long animals which form these remains to live and be happy. To figure out if this is true, people went to a very warm place where in one side of the land the water was very cold and on the other side it was very warm. What they found was that the cold side had these remains, but the warm side did not. This means that these animals can live in warm places if the changes in the water allow for places with cold water.
Hirano, Takahiro, et al. "Cretaceous amber fossils highlight the evolutionary history and morphological conservatism of land snails." Scientific reports 9.1 (2019): 1-16.
Quiroz, Luis I., et al. "the search for an elusive worm in the tropics, the past as a key to the present, and reverse uniformitarianism." Scientific Reports 9.1 (2019): 1-8.

domain: biology


Introducing the 70m/s Cordless Air Duster, a revolutionary tool for computer cleaning that replaces traditional compressed spray gas cans. This rechargeable cleaner blower is designed to provide a deep and thorough cleaning experience.
The Cordless Air Duster stands out in the market with its ability to generate a robust air thrust of nearly 70m/s, ensuring deep cleaning of microscopic dust particles. It’s perfect for cleaning a wide range of items, from printed circuit boards to computers, electronic instruments, medical devices, and more. This mini duster can reach places your traditional wiper or duster can’t.
The Air Duster is engineered for fast charging and speedy functionality. It’s designed to charge quickly with a 2A adapter (not included), and its motor can reach a maximum rotating speed of up to 45000 RPM.
The device features a handy design and simple operation. It has an extended full-palm gripping design and a withdrawable nozzle, ensuring comfortable and easy use.
This Air Duster is eco-friendly and energy-efficient. It supports our responsibility to save gas and water, as it allows for more than 5000 uses, saving a significant amount of energy. This mini duster is a perfect blend of cleanliness and eco-friendliness.
The device also features a lighting design, ensuring you can use it even in the dark. The warm heart lighting design illuminates dark areas, leaving no place for dust to hide.
Material: ABS PP
Voltage: DC 5V
Motor Speed: 45000 RPM
Wind Speed: 70m/s
Optional Battery Capacity: 6000mAh/15000mAh
Charging Interface: Type-C Interface
Charging Time: 4H/7H
1-Gear Using Time: 0.5H/1H
2-Gear Using Time: 0.35H/0.8H
Size: 20.5 x 7.5 x 13 cm/8.07″ x 2.95″ x 5.12″
1 x Cordless Air Duster
1 x Long Hair Brush
1 x Long Blowing Mouth
1 x USB Charging Cable
1 x User Manual


Wizkid is set to release the first single off his highly anticipated album “Made In Lagos”
Wizkid has finally let the cat out of the bag, he would be dropping the single with American singer, H.E.R by midnight which falls on his 30th birthday. Wizkid had his fans on their toes for the album after announcing the producers and artistes on the album. He listed the likes of London, Blaqjerzee, P2jmuisc, Julsbaby, Sarz, Kel P, Mut4y for the producers. The artistes include H.E.R, Damian Marley, Ella Mai, Tems, Starboy Terri, Skepta, Burna Boy, and others.
Wizkid actually hinted the name of the track “Smile” a few days ago in a simple tweet but many felt it was just one of his random happy tweets. In a new Instagram post, Wizkid confirmed that the track would indeed be dropping and right now, he is trending topic on all coil media platforms.
— Wizkid (@wizkidayo) July 11, 2020
View this post on Instagram


text:
The NAS team pulled out all the stops for the Virtual Reality Gaming Experience on Wednesday, 8 March, offering students an opportunity to try out the latest, and most advanced, Virtual Reality technology – the HTC Vive. To celebrate RMIT University’s new Student Portal on Level 7 of Building 10, eager participants were given VR headsets and a set of motion controllers to experience the new tech firsthand. Free NAS-branded lunchboxes and $1 coffees were on offer for all in attendance.
Three booths kitted out with motion capture cameras and HTC Vive headsets featured three different games. A cartoon archery simulator called Longbow had players protecting a castle from invaders by shooting them before they reached the drawbridge. Space Pirate was a fast-paced, futuristic shooter that focused on destroying oncoming spaceships in order to earn high scores. The most popular game was The Brookhaven Experiment, a survival shooter that involved fighting off hoards of zombies, armed with nothing but a handgun and flashlight.
Crowds of students waited in line for each booth as onlookers gathered around to watch the games, anticipating their turn. There was some healthy competition as players aimed for the high score and cheered each other on. Plenty of laughs were had when things didn’t go according to plan – one player ran out of bullets and yelped as the zombies approached.
VR technicians helped participants in and out of their gear efficiently and explained how to use the controls so even the inexperienced could feel confident.
Vince Turcarolo, a Bachelor of Engineering (Civil and Infrastructure) student, seemed thrilled as he walked away from the VR booth.
“This was my first time using VR and I’m really impressed. The space here has been set up really well and [the game] is really accurate to how you’re moving.”
Other students agreed, using the new facilities to study and socialise with peers.
Words by Christie McQualter

domain: news


text:
Guidelines for the Alice Tag Book Swap
For this swap, you will create 6 tags with the theme of "Alice". Your tags can be inspired by Wonderland or Looking Glass. Please use approximately 4-1/2" by 2-1/2" tags. You don't have to be exact, but do try to be in that ballpark so that your tags will fit well with the books. An inch or so either way will work, because variety is nice.
Also, feel free to cut your tag out of any material you want to use. You DO NOT have to use a pre-made shipping tag. You may fabricate your own from fabric, metal, chipboard, etc. You have the option of finishing both sides of the tags as elaborate as you'd like to. Or leaving the back plain, its up to you.
PLEASE SIGN YOUR TAG! If you have a blog, please include the address. But you DO NOT HAVE TO BE A BLOGGER TO JOIN IN.
Once the tags arrive at my cottage, I will sort them into piles that look cute together and assemble the books from 6 different tags, plus add a cover that I have made. You might receive your own tag back in the book you get.
Please have your 6 tags to me by March 10th. Along with your tags, please send $6 for postage and supplies. Also include your address written onto a label for the the package. It doesn't have to be a sticky label, a piece of paper I can tape down is fine.
If you have a blog, here is a button you can add.

domain: artistic


text:
Free shipping applies only to standard UPS ground shipping, within the forty-eight (48) contiguous United States. Orders shipping to HI, AK and PR will incur a $30 surcharge, per item, when order is placed.
Hang ten! After an awesome day at the beach, your little guy or gal is definitely going to enjoy these rad wave-inspired rugs! Catch a wave close to home with these cool ocean designs in your children's bedroom or playroom!

domain: geography


text:
“Oh the places you’ll go” features the amazing career paths of VACorps alumni. In this inaugural post, Nicole Beaudoin describes her steady rise within the international film industry that first started in South Africa. Nicole participated in a film and photography internship in January of 2007 and worked as a production assistant at Stillking Productions.
“After my internship in Cape Town, I graduated from UW and moved to Austin, TX to pursue a career in the film industry. I worked on some great projects, both smaller independent movies and larger movies such as Richard Linklater’s BERNIE and post-production on Terrance Malick’s TREE OF LIFE. I was able to work in various positions moving up the ladder in the production office, culminating in line producing a low budget feature film GROW UP TONY PHILLIPS, which premiered at SXSW 2013 was released Fall 2014.
“In 2013, I was a local hire for TRANSFORMERS 4 for the Austin portion of the shoot, and the production office team ended up bringing me along for the entire shoot to Michigan and Chicago. It was an incredible experience to work on such a “big” blockbuster type movie and see first-hand the craziness and the scale of something where they are closing down city blocks in a major metropolitan area, there are hundreds of extras, and constant explosions.
“I have since moved to Los Angeles, where I have been roughly a year and a half. The amazing line producer TRANSFORMERS 4 was offered a SVP position in Physical Production at Paramount Pictures and asked me to be her coordinator. I never thought I would work for a studio, and it really is a dream job and amazing learning experience to walk through the historic gates of Paramount every day and be a part of the moviemaking process on so many films.
“However, I will never forget my first time on a professional set, and what a wonderful peek into the world of production it was for me. That experience was during my internship at Stillking films in Cape Town. The whole experience of an internship in Cape Town was such a growing experience for me. I look back on my time there and see it as a period of exponential growth and a big booster to my confidence.”


Wide-ranging weather across the Nation
Hot weather will continue indefinitely in the Northwest, but near- or below-normal temperatures should prevail in many other areas of the country. In fact, significantly below-normal temperatures can be expected across the Plains and Midwest. Meanwhile, a series of cold fronts will produce scattered showers across the northern Plains and Midwest before reaching deeper moisture and resulting in locally heavy downpours across the South and East. Five-day rainfall totals could reach 1 to 4 inches across the South, East, and lower Midwest. In the Four Corners States and environs, monsoon-related showers could total 1 to 3 inches or more. Mostly dry conditions will persist, however, in the Pacific Northwest.
Looking ahead, the 6- to 10-day outlook calls for the likelihood of below-normal temperatures across a large swath of the country, particularly between the Rockies and Appalachians. Hotter-than-normal conditions will be limited to the Far West, as well as Florida’s peninsula and Deep South Texas. Meanwhile, below-normal rainfall in Arizona and from the Pacific Northwest to the northern Plains should contrast with wetter-than-normal weather elsewhere, including the central and southern Plains and much of the South and East.
NOAA’s 6- to 10- Day Outlook
NOAA’s 8- to 14- Day Outlook
Your email address will not be published.
Subscribe for our newsletter today and receive relevant news straight to your inbox!


text:
News and Events – Madame Tussauds Hong Kong
News and Events
Displaying 31-40 of 50 results
Tuesday, 24 June 2014
Michael Jackson fans paid tribute to the King of Pop at Madame Tussauds Hong Kong, visiting his wax figure to mark the fifth anniversary of the superstar’s death tomorrow.
Friday, 20 June 2014
Summer is just around the corner! To welcome this season of fun and enjoyment, Madame Tussauds Hong Kong has prepared a host of surprises and new figures for guests when they visit the attraction.
Thursday, 08 May 2014
Indonesian founding father and one of Asia’s most important national and international leaders, President Soekarno, made his way to Madame Tussauds Hong Kong today.
Tuesday, 20 May 2014
2013 FIFA Ballon d’Or award winner and one of the most influential players in sports today, Portuguese footballer Cristiano Ronaldo is ready to tackle his way through Hong Kong football grounds and score goals before arriving at Madame Tussauds Hong Kong t
Thursday, 08 May 2014
Countdown to the 2014 FIFA World Cup with the launch of Cristiano Ronaldo's wax figure at Madame Tussauds Hong Kong at the end of May!
Tuesday, 04 March 2014
Ranked World No.5 by the Women’s Tennis Association and with 29 WTA singles championships, including four Grand Slam singles titles to become the top Russian female player, Maria Sharapova sets foot onto the tennis courts before she joins the other A-list
Monday, 13 January 2014
Madame Tussauds Hong Kong is set to welcome its second Korean star to the attraction.
Monday, 30 December 2013
December marks the 10th Anniversary since Anita Mui left us and Madame Tussauds Hong Kong and Mui Nation have co-organised the ‘Ever Changing New Style, Never Changing Memories’ unveiling ceremony for Anita Mui’s newly restyled wax figure. Each of Anita’s
Wednesday, 18 December 2013
Seven major tourist attractions in Hong Kong — Hong Kong Wetland Park, Madame Tussauds Hong Kong, Ngong Ping 360, Noah’s Ark Hong Kong, Ocean Park Hong Kong, The Peak Tram & Sky Terrace 428, and sky100 Hong Kong Observation Deck, are joining hands to prese
Monday, 23 December 2013
New World First Bus (“NWFB”), Citybus and Madame Tussauds Hong Kong jointly present the ‘Madame Tussauds Bus Pass’ package, tailored for Hong Kong travelers and visitors to enjoy the city's best entertainment activities and attractions.


text:
LEHIGH ACRES, Fla.- Three teenagers are under arrest in a string of vehicle burglaries in Lehigh Acres.
Kegan Boyle, 18, and Kelly Wells, 19, each face more than 30 counts of burglary, grand theft and dealing in stolen property.
The break-ins took place in the Sunshine Boulevard area and were stopped when one of the victims caught the thieves rummaging through her car. Family members of the victim chased after and caught one of the suspects, holding him until deputies arrived.
Christian Tezekjian, 19, the alleged lookout, is also charged with one count each of burglary and grand theft.
Detectives say the suspects were taking their stolen property to a couple of acquaintances and served a search warrant for a home on the 3200 block of 72nd Street West.
Authorities discovered stolen property from recent burglaries, including tools and a custom remote control racing boat. Detectives also found 38 grams of cocaine, 130 Xanax pills and 240 grams of marijuana. There was also a small amount of marijuana in a form called “shatter” which is an extremely potent type of THC. Two tactical rifles and $2,000 cash were also seized.
Jacob Kluch, 19, and Samuel Jones, 21, who were inside the home at the time, also face drug possession charges and could face additional charges as the investigation into the stolen property continues.


text:
📖Sahih al-Bukhari 7179
Narrated Abu Huraira: Allah’s Messenger (ﷺ)s said, “The worst of all mankind is the double-faced one, who comes to some people with one face and to others, with another face.
- This hadith refers to the behavior of hypocrites who pretend to have different beliefs, attitudes, or personalities when dealing with different people. They display one face in front of some people while concealing their true face and intentions from others. This behavior is considered the worst among all people because it involves deception, insincerity, and betrayal of trust. The hadith serves as a warning against hypocrisy and encourages Muslims to be honest and consistent in their behavior with all people.

domain: psychology


text:
Thirty-six parents of colicky infants participated in this randomized, placebo-controlled clinical trial conducted via the Internet. Parents recorded a baseline state-of-arousal diary for 3 days using their usual feeding methods, and then they used six study-provided bottles for 2 weeks while recording a second state-of-arousal diary. Infants being fed with placebo bottles significantly spent more time crying (ρ = .010) and fussing (ρ = .002) on average than infants using Dr. Brown's Natural Flow Baby Bottles. Because these bottles decreased the time the infants spent crying and fussing, use of these bottles may be recommended for colicky infants who receive any bottle feedings.
ASJC Scopus subject areas
- Advanced and Specialized Nursing

domain: medical


text:
My CAS Experience was about figuring out how to cook, cooking is a significant skill for survival. I know the essentials of cooking like cutting, chopping, frying and so forth from my AS classes. Yet, I couldn’t invest my time as a result of school and other extracurricular activities.
Learning Outcome 1 – Identify own strengths and develop areas for growth
I have always loved eating, and cooking was something that will help me embrace it. During the pandemic, I understand that cooking all alone is a significant ability when I don’t have anybody to make food for me. All through the process, I acquired a lot of new abilities and identified that I am acceptable at following guidelines and cleaning after the process. There were also things which I’m bad at such as I was impatient for cooking dishes that took a ton of time or which made the dishes not wonderful enough.
Learning Outcome 2- Demonstrate that challenges have been undertaken, developing new skills in the process.
The experience was itself a test, I challenged myself to figure out how to cook 10-15 dishes throughout the course of 14 days. I was pleased to reveal to you that I was able to effectively make 10 distinct dishes throughout the span of 12 days. Despite the fact that I had been successful to effectively finish it, that didn’t imply that it was a tough road. There were numerous challenges that I faced, for example, for one I was bad at multitasking, and I was having issues with controlling high temperatures. To overcome this I started managing more efficiently by completing the step and then moving on to the next and with respect to the high temperature I use safety measures so I don’t get burned. By undertaking the difficulties and challenges that were thrown at me makes me a better cook.
Learning Outcome 3-Demonstrate how to initiate and plan a CAS experience
I Used to plan on what dish I was going to make in the span of 10 days. The plan included the recipe for the dish, the ingredients, the apparatus and the utensil that I required for the dish. I am not an organized person but the plan helped me to be prepared so that while I am cooking I don’t forget something that is crucial in the process of making the dish. The plan also helped me to prepare beforehand for recipes like Noodles, you have to boil the noodles beforehand. During the planning process I developed Time management skills as there are things in cooking that need to be done before the process.
Learning Outcome 4 – Show commitment to and perseverance in CAS experiences
Commitment And Perseverance Is a Significant part of the experience. If you know me you would realize that I am the laziest person that you would have met, so it was difficult for me to be committed to cooking. The only thing all through the experience that motivated me to cook was the fun and the joy to eat after all the hard work. Committing to something brings the joy of accomplishing something, and its absence feels like a 9-5 job that one needs to accomplish for the money, not the pleasure.
Learning Outcome 7-Recognize and consider the ethics of choices and actions
As I was not an expert in cooking there were a ton of ingredients that were wasted for instance while making the batter you need to accomplish a specific consistency but if you can’t achieve that consistency everything is gone in drains. The other decision was if to cook healthy or not, in which I failed. Despite the fact that I made certain dishes that were health-conscious yet the greater part of them was for simply gaining me weight.

domain: food


text:
The southeast corner of Queensland has taken a battering from the weather during the day, and it’s only expected to get worse during the evening.
Up to 400mm of rain is expected in some areas before the low system and trough causing the problems move away.
Residents in low-lying areas are sandbagging their properties against flooding and preparing for gale force winds.
Roxanne Jeynes reports.
The weather bureau has been warning of foul and nasty weather, heavy rain and some flooding to increase during the day.
And the rough conditions hit the coastal areas first with choppy seas.
Most boaties, although apparently not this one, avoided the weather.
Residents in dozens of suburbs have been battening down for what could be gale force winds.
The council is providing sandbags in suburbs like Zillmere, Darra, Morningside, Lota and Newmarket, where local flooding is likely.
Rod Bernard, Local Resident: “This is the first time ever I’ve had to pick up sandbags, I think the intensity of the storm is what makes it particularly different this time.”
For most of the day, Brisbane had escaped any heavy rain, but by midday things had changed with the big wet setting in.
It’s predicted we will witness cyclone-like conditions with heavy rain affecting much of the south-east coast.
Forecasts suggest Brisbane could get between 200 and 400mm of rain, with wind gusts up to 90kph.
Popular Mt Coot-tha was empty today.
The tourists stayed away, except for this visitor from Sydney.
Shreyas Vimalkumar, Tourist: “Heard a lot about Mt Coot-tha, we’re here, but unfortunately we can’t see anything ’cause of the rain, unfortunately I think it’s following me, fingers crossed it doesn’t follow us to the Gold coast.”
Further down south, the Gold Coast did also experienced a relatively calm morning, but as the day progressed the weather deteriorated.
Minor flooding forced the closure of some roads in the hinterland.
The low is predicted to intensify throughout the evening.
Gold Coast beaches remained closed all day, battered by massive waves and high tides that could cause erosion along the Coast.
The wet weather, however, is seeing some happy retailers.
Andy Last, Shop Manager, Australia the Gift: “I think that probably 80-90% of sales so far have been umbrellas.”
And we are being warned to keep those umbrellas handy until conditions ease at 4am tomorrow morning.
Roxanne Jeynes, QUT News.


Jockey® 3D-Innovations® White Brief
FREE SHIPPING ON ORDERS OVER RS. 2,500/-
CASH ON DELIVERY | VISA/MASTER | BANK TRANSFER.
The Jockey® 3D-Innovations® brief engineered cuts of fabric are combined at various angles allowing products to stretch in any direction. Unique process where the final stitch flat which avoids uncomfortable friction to your skin. Soft and smooth to the touch, offering added flexibility and stretch for ease of movement.
- Full coverage
- 47% Cotton | 47% Modal | 6% Spandex
- Added flexibility and stretch for ease of movement
- Machine Wash | Do Not Bleach | Machine Dry


text:
Being Turkey's "most crowded breakfast table," the Van breakfast has been licensed and will be promoted as a special brand with the initiatives of the Turkish Patent Institute (TPI).
Breakfast culture in the eastern province of Van is renowned across the country. A Van breakfast starts with traditional Turkish breakfast items, such as olives, omelets, menemen - scrambled eggs cooked with tomatoes, green pepper and spices - honey with kaymak (clotted cream), homemade jams, fresh cucumber and tomatoes, then an array of Van cheeses, herbs, the famous Van honey and pekmez - molasses made from the grapes of Van.
Faris Gül, a breakfast hall owner in Van, said the breakfast reflects the region's character. "What we serve in the Van breakfast is all our productions," he said, adding a breakfast table features at least 20 items and can be expanded to 30. Another breakfast hall owner in Van, Yusuf Konak said they are planning to have a breakfast festival in the near future. "We have another project to promote the Van Breakfast abroad. All preparations have been done for it. The first stage of it will take place in Germany and we will introduce and serve our breakfast culture there."
In 2014, Van set a world record for the most crowded table, surpassing the one belonging to the U.S. with 18,941 people. The record was broken with almost 52,000 people. In order to break the record, 25,000 chairs and 6,000 tables were set up in a field. Those who failed to find a table brought their own tablecloths to sit on the ground.
to read our informative text prepared pursuant to the Law on the Protection of Personal Data No. 6698 and to get information about the
used on our website in accordance with the relevant legislation.
6698 sayılı Kişisel Verilerin Korunması Kanunu uyarınca hazırlanmış aydınlatma metnimizi okumak ve sitemizde ilgili mevzuata uygun olarak kullanılan
ilgili bilgi almak için lütfen


text:
Flynn is a practising artist and architectural graduate based in Meanjin/Brisbane. A fascination with nostalgia is what drives his work across mediums; Architecture, Interior design and visual art.
Flynn values design and visual art that is creative, resourceful and timeless. His resourcefulness lends an artistic quality to his work, with Flynn being particularly interested in using project materials, at their raw and truest form, in sculptural ways. This expressive quality of his practice stems from his interest in architecture that’s more than a liveable building. Through this creative determination, he is striving to build a career that merges his two worlds of architecture and art.

domain: design


text:
When we hear the word Mexico, there are many things that pop in to our minds. Chilli is probably the first one we mention, followed by tequila, Margaritas, Mariachi,tacos and definitely Speedy Gonzalez.
Some people with a deeper cultural knowledge will mention the Aztecs, teotihuacan, the Mole sauce and Chespirito. Anyhow, Mexico is a culture that has many hidden, bizarre and curious facts within its history, indigenous background, legendary heritage and amazing cuisine.
Here are some of the most interesting fun facts about Mexico that we could find:
2. The word Mexico means ” moon’s belly button”, from the Náhuat “Metztli” (luna/moon) and “xictli” (belly button).
3. On November 2010 Mexican cuisine was added by UNESCO to its lists of the world’s “intangible cultural heritage”
4. Mexico is the country with the largest number of taxis: 60.000
5. Mexico city has the largest number of museums in the world.
6.Mexico has the world’s smallest volcano. The Cuexcomate, in the city of Puebla, is only… 43 feet tall!. It is considered to be inactive now, and it has a spiral staircase inside, just for tourists.
7. A Mexican tamale called the zacahuil is three feet long and weighs about 150 pounds.
8. If you stand by the pyramid Chichen Itza you will hear a bird singing.
9.The name “tomato” derives its etymology from the sacred Aztec language
10. The caesar salad was first created by Caesar Cardini in Tijuana, Mexico
Hope you enjoyed it!
Pretty intereseting right?


text:
Here’s the Bryan Connolly Trio playing Thelonious Monk’s “Ruby, My Dear,” first recorded in 1947.
If you play this through decent speakers, then Randall Pharr’s solo on bass, and David Roberts’ on guitar will resonate both your pericardial cavity AND your brainpan. Brian C’s drumming supplies quiet amperage, no distractions.
You probably told yourself, right away, that thanks to some semi-incompetent video work (mine), these guys look as if they’re playing within an animated oil painting from Northern Europe, around the 1600s. You figured, “It’s Johannes Vermeer’s The Concert,” and you’re right.
We can’t check the original. It was stolen in 1990, and it’s said to be worth $200,000,000 if they ever find it. But if you listen to live Richmond jazz you get that much value, maybe more. And they can’t steal this from you. Not even these days.


Ohio natives Mayfly call small label Voluminous Records home. They are amongst only three bands currently signed to their roster. While Voluminous may not be a well-known label at this point (founded in 2006), their commitment to the Christian faith and Christian artists is highly respectable. Their webpage states: "Although we don't require that the music be specifically Christian in theme, we do expect members of each band on the label to be Christian and act in a way consistent with a follower of Christ." It goes on from there, but that is a strong statement in and of itself. Mayfly themselves bring a sound with strong nu-metal elements mixed in with some more modern alternative metal elements. The band calls the sound "recycled nu-metal." Their sound has been compared to early era Deftones and they draw influence from the likes of bands such as Underoath, As Cities Burn, and Dead Poetic. Their newest EP, Vereor Deus Non Dogma, is a Latin phrase which translates to "Fear God, Not Dogma." Before you even get to the music the horrific album cover of a man in a gas mask holding a large knife to another man's throat will surely grab your attention.
The EP opens with a spoken word track entitled "Choice." The track won't give you much insight on the musical direction, but it does set the tone thematically. The words, "To fear is to separate; the fear of God, or a fear man made," as well as the remainder of the piece gives the basis for the album title's meaning. The guitars kick in full force to open "Infidel Castro" and it doesn't take long to figure out what these guys are all about musically. The rapid paced guitars throughout, coupled with the headbanging breakdown halfway through, make it a nice start. Folks like me, who miss the band Staple, will be pretty stoked by Darin Keim's guest appearance in "Jihad." A loud bomb raid siren fittingly opens the song about a holy war. While the term is not used in the exact Muslim context, it works well within the lyrics of the song. While "Eternal Respirations" definitely carries a darker Deftones/nu-metal vibe musically, its melodic chorus brightens it up a bit. "Skylights" is up next and goes back to the more rapid pace found earlier in "Infidel Castro." The track actually turns out to be one of best tracks on the album and features some more hardcore elements and even some Project-86 like moments vocally. "Fiasco" is the last actual song carries more of a Dead Poetic "Vices" sound. It's the softest tune on the EP and probably stands the biggest chance of radio success. After several solid tracks, unfortunately, the EP ends with a remix of "Eternal Respirations." This nu-metal jam gets turned into an industrial travesty. The electronic elements sound a bit cheesy overall and the song suffers greatly. This one should have been left off.
Mayfly have, in a sense, resurrected a style of music from years past. While there are some bands still using that old nu-metal sound, it's not nearly as prevalent today. Some people claim that nu-metal ruined rock music, while others will argue that nu-metal actually saved the genre. Whatever your opinion on the matter, Mayfly have done nothing short of putting themselves on the map as a band to watch in the future. Vereor Deus Non Dogma is nowhere close to perfect, but it does offer up quite a few enjoyable moments. While a direct comparison to the Deftones is a stretch for me (Chino's voice makes the Deftones sound in my opinion), the musicality of the EP is definitely leaning that way. The musicianship is respectable and the lyrics are good. If you're looking for something new that can also flash you back to the days when Korn and other nu-metal acts dominated the airwaves, Mayfly is probably a pretty good option. Keep your eyes peeled for what Mayfly and Voluminous Records do next.- Review date: 2/8/14, written by Michael Weaver of Jesusfreakhideout.com
|Amy Grant and Michael W. Smith Reunite for Seven Christmas Performances Across U.S.|
Mon, 15 Jul 2019 20:00:00 EST
|Elevation Worship Releases New Youth Worship Expression as ELEVATION RHYTHM|
Mon, 15 Jul 2019 12:20:00 EST
|Chris August Signs to BMG Music Publishing|
Sat, 13 Jul 2019 15:20:00 EST
|Sara Groves, Audrey Assad, Ellie Holcomb, Propaganda and Robbie Seay Band Unite for Recently Released "Behold"|
Fri, 12 Jul 2019 17:10:00 EST
|Royal Company Debuts New Single "Faithful Is Your Love" On DREAM|
Fri, 12 Jul 2019 17:00:00 EST
|NF Releases New Single and Video "Time" Ahead of Album Release|
Fri, 12 Jul 2019 16:10:00 EST


text:
September 2016 | VOL. 15, NO. 9| www.McGowan.pitt.edu
The Clinical and Translational Science Institute (CTSI) sponsored the 4th Pitt Innovation Challenge. This year’s challenge was focused on bold solutions in health. CTSI aims to move health-related research projects along the translational spectrum, not just to commercialization. Ideas and solutions did not need to be products ready for commercialization—basic science projects were encouraged to apply. In addition, the program encouraged new connections within the academic community, and among universities and community organizations, to foster an ecosystem of innovation.
The following teams, including McGowan Institute for Regenerative Medicine affiliated faculty members and their trainees, were winners in this year’s competition:
Winners of $100,000 (each):
Team: Juan Diego Naranjo, Lindsey Saldin, and Stephen Badylak, DVM, PhD, MD
Description: Minimally invasive treatment for Barrett´s Esophagus causing disease regression and mitigation of cancer risk.
Team: Bryan Brown, PhD and Paul Gardner, MD
Description: For those seeking better ways to treat and recover from nerve injuries, NeuroGel is an injectable solution that provides a simple and effective method for enhancing nerve reconstruction.
Winner of $25,000:
Team: Jingyao Wu and Prashant Kumta, PhD
Description: VasoMag is a novel engineered biodegradable metallic vascular stent technology that provides superior mechanical support to open the narrowed vessels and maintain the needed patency while safely degrading in 6-12 months.
Videos of the award-winning technologies are available at www.pinch.pitt.edu
Congratulations to all!
RESOURCES AT THE MCGOWAN INSTITUTE
S100 is normally present in cells derived from the neural crest (Neural crest cells are a transient, multipotent, migratory cell population unique to vertebrates that gives rise to a diverse cell lineage including melanocytes, craniofacial cartilage and bone, smooth muscle, peripheral and enteric* neurons and glia), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, dendritic cells, and keratinocytes. It may be present in some breast epithelial cells.
* The enteric nervous system (ENS) or intrinsic nervous system is one of the main divisions of the nervous system and consists of a mesh-like system of neurons that governs the function of the gastrointestinal system.
Several members of the S-100 protein family are useful as markers for certain tumors and epidermal differentiation. It can be found in melanomas, 100% of schwannomas, 100% of neurofibromas (weaker than schwannomas), 50% of malignant peripheral nerve sheath tumors (may be weak and/or focal), paraganglioma stromal cells, histiocytoma and clear cell sarcomas. Further, S100 proteins are markers for inflammatory diseases and can mediate inflammation and act as antimicrobials.
The Histology Lab at The McGowan Institute offers competitive pricing for IHC staining, including “working up” new protocols for Paraffin and Frozen sections. We have S100 already up and running and will waive the work up fee for the month of October! Bring your slides, blocks, frozen or fixed tissue to the histology lab for S100 staining. You are guaranteed beautiful results.
Contact Lori at the McGowan Core Histology Lab by email or call 412-624-5265. As always, you will receive the highest quality histology in the quickest turn-around time.
Did you know the more samples you submit to the histology lab the less you pay per sample? Contact Lori to find out how!
Over the past months the work from several investigators utilizing the McGowan Institute Flow Cytometry Facility has been highlighted. Many of the researchers are from the McGowan Institute, but they also hail from many different departments within the University of Pittsburgh and UPMC including the Magee-Women’s Research Institute, Microbiology and Molecular Genetics, Cellular and Molecular Engineering, the Department of Physical Medicine and Rehabilitation, as well as the Medical Devices Laboratory.
Cell types range from the traditional immortal cell lines and white blood cells to small spiny neurons, spermatogonial stem cells, muscle stem cells, human fetal liver cells, human and mouse bone marrow cells, pericytes, astrocytes, tissue resident macrophages, and many others. Sample species include human, non-human primate, mouse, rat, pig, and even lizard! If species-specific, cell-specific monoclonal antibodies are available – your cells can be analyzed by flow cytometry.
And, flow applications are not limited to cell surface antigen characterization and cell purification. Other applications include apoptosis via caspase function, TUNEL assay and/or annexin staining, mitochondrial function, autophagy, DNA ploidy, proliferation, transcription factor analysis, cytotoxicity, screening for transfection efficiency, enzyme activation state, intracellular presence of cytokines, cytokine quantitation via bead-based assays, and many, many others.
Please stop by the McGowan Institute Flow Cytometry Facility, Suite 300, to discuss with Lynda Guzik, Facility Manager, how flow cytometry can enhance your research projects.
This symposium features renowned researchers and clinicians focused on regenerative rehabilitation treatments and therapies. This emerging field translates discoveries in tissue engineering and cellular therapies into treatments that benefit the functional outcomes of patients. These stimulating innovative approaches are explored with meeting attendees.
The symposium will be held on October 14-16, 2016 at Emory University in Atlanta, GA.
This symposium encourages participation of scientists, clinicians and physical therapists that are in the fields of regeneration and / or physical medicine and rehabilitation. This gathering is a platform for bridging these two areas of expertise in a setting that fosters discussion, interaction, cross discipline pollination intersection and networking.
For more information and to register, please click here.
The Pittsburgh Liver Research Center (PLRC) Grant Review Committee has selected the awardees for the 2016-2017 grants. Congratulations to the following McGowan Institute for Regenerative Medicine awardees of the 1-year PLRC Pilot and Feasibility Grants:
- PI Bryan Brown, PhD (Department of Bioengineering) and Elizabeth Stahl (Department of Pathology)Macrophage-Extracellular Matrix Interactions in the Aging Liver—The proposal investigates the role of the extracellular matrix in the changing of origin and functionality of macrophages which have been observed in the liver with age.
- PI Alex Soto-Gutierrez, MD, PhD (Department of Pathology), PI James Squires, MD, MS (Department of Pediatrics), and Co-PI Charleen Chu, MD, PhD (Department of Pathology)
Potential of Human Induced Pluripotent Stem Cells in Studies of Progressive Intrahepatic Cholestasis—The goal of the proposed research is to understand the mechanisms that govern the incapacity of hepatocytes to secrete bile in progressive familial intrahepatic cholestasis (PFIC) disorders. This research will improve the understanding of low-gamma glutamyltransferase (GGT) PFIC by providing an optimal platform for modeling and recapitulating key aspects of the disease ultimately providing an opportunity discover insight into mechanisms underlying low-GGT PFIC and serve as a potential to develop and test disease specific novel therapeutics.
Congratulations to all!
Combining ultrasound energy and microbubbles to poke holes in cells may prove to be a new tool in the fight against cardiovascular disease and cancer, according to researchers from the University of Pittsburgh and UPMC. A study on this gene therapy approach, called sonoporation, appears in the Proceedings of the National Academy of Sciences (PNAS). McGowan Institute for Regenerative Medicine affiliated faculty members Flordeliza Villanueva, MD, Professor of Medicine in the Division of Cardiology and Vice Chair for Pre-Clinical Research of the Department of Medicine, and Simon Watkins, PhD, Founder and Director of the Center for Biologic Imaging at the University of Pittsburgh, member of the Pittsburgh Cancer Institute, and also a Professor and Vice Chairman within the Department of Cell Biology, are co-authors on the study.
“We can use ultrasound energy in combination with small, gas-filled bubbles to selectively open up cells to allow the delivery of therapeutic agents,” said Brandon Helfield, PhD, lead author of the study and a postdoctoral fellow at the Center for Ultrasound Molecular Imaging and Therapeutics at UPMC. “With a focused ultrasound beam, this approach lets us tune this delivery to the precise location of disease while sparing healthy tissue. Our study looks at some of the biophysics at play and helps us get closer to refining this technique as a clinical tool.”
Current approaches to gene therapy often use viruses to gain access inside cells, which can cause severe side-effects, including inflammatory immune system reactions. To address this, researchers have developed gene-loaded intravascular microbubbles that can be targeted to release their payloads by direct navigation of focused ultrasound energy.
The Pitt researchers developed an ultrafast imaging camera capable of reaching speeds up to 25 million frames per second—the only one of its kind in North America. Using the camera, these researchers examined the biophysics of sonoporation. They determined that the oscillating bubbles need to generate a minimum amount of localized shear stress, beyond which cell membranes perforate and allow entry of a targeted therapeutic.
“By allowing us to actually see the microbubbles vibrating at millions of times per second, our unique camera enabled us to determine that microbubble-induced shear stress is the critical factor for sonoporation,” said Xucai Chen, PhD, research associate professor of medicine, Pitt Division of Cardiology, and Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, who co-developed the camera system. “This new information, in turn, will facilitate the intelligent design of treatment protocols and microbubble fabrication to preferentially cause the desired effect of opening nearby cells. It also gives us a starting point to investigate how cells cope with this treatment.”
Researchers believe the findings will help them understand how the process of sonoporation works, as well as how experts can tailor the approach, including ultrasound amplitude levels and microbubble designs, toward its eventual clinical use.
“It’s critical for us to understand the biophysical mechanisms of sonoporation in order to translate this approach into an effective gene or drug delivery tool for patients,” said Dr. Villanueva, the senior author of the investigation. “Building on the PNAS study, we are continuing to investigate how sonoporation affects the function of treated cells and to develop strategies to maximize its therapeutic effects.”
Illustration: Fluorescently labeled endothelial cell monolayer, pseudocolorized in blue/green, and imaged using spectral confocal microscopy. One cell has been selectively perforated via ultrasound-induced microbubble cavitation (simultaneously captured by ultrafast imaging, top panels), allowing the entrance of a model therapeutic (orange). UPMC.
Abstract (Biophysical insight into mechanisms of sonoporation. Brandon Helfield, Xucai Chen, Simon C. Watkins, and Flordeliza S. Villanueva. Proceedings of the National Academy of Sciences; August 22, 2016.)
The microenvironment that supports a cancerous tumor also starves the immune cells that the body sends in to destroy the cancer, University of Pittsburgh Cancer Institute (UPCI) scientists revealed in a discovery that holds the potential to significantly boost the performance of breakthrough immunotherapy drugs.
The UPCI team—including McGowan Institute for Regenerative Medicine affiliated faculty member Simon Watkins, PhD, Founder and Director of the Center for Biologic Imaging at the University of Pittsburgh, a member of the UPCI, and also a Professor (with tenure) and Vice Chairman within the Department of Cell Biology—showed that when immune T cells enter the tumor microenvironment, their mitochondria—which act as mini-factories inside cells, making energy and crucial reagents a cell needs to survive—begin to shrink and disappear, indicating that the T cell is out of fuel and can’t do its tumor-destroying job. The finding opens the door to several potential clinical approaches that could help keep T cells functioning and boost the body’s ability to fight cancer.
“Immunotherapy to stimulate the body’s immune system has increasingly become the way we treat people with aggressive cancers. It’s effective for a subset of patients, but the truth is that only about 20 to 40 percent of patients will respond to the treatment, and it is still unclear why,” said senior author Greg M. Delgoffe, PhD, assistant professor of immunology and member of the Tumor Microenvironment Center at UPCI, partner with UPMC CancerCenter. “It’s a huge question in the cancer immunotherapy field, and we think we’ve found a big part of the answer.”
As tumors grow, they build a microenvironment, which develops its own blood supply and keeps the tumor thriving, protected, and voraciously consuming all available nutrients.
When T cells enter the microenvironment, it’s as if they’re “automobiles that suddenly had the emergency brake applied; they can’t keep driving,” explained Dr. Delgoffe. Immunotherapies, like those that target negative regulators on the T cell surface, take these brakes off. “However, what we’re discovering in many cases is that even though the brakes have been taken off, there isn’t any fuel in the tank,” Dr. Delgoffe said. Or—in scientific terms—the lack of mitochondria in the tumor-infiltrating T cells keeps them from functioning.
“This is an exciting discovery because we already have various strategies to ‘fill the fuel tank’ and support T cell function in the tumor microenvironment,” said Dr. Delgoffe.
In laboratory experiments and tests with mice, Dr. Delgoffe and his team found that when they boosted the mitochondria in the T cells, they were better able to clear the tumor.
Dr. Delgoffe is partnering with other scientists to test various mitochondria-boosting strategies, including using drugs that already have proven safe in humans, such as those for type 2 diabetes, to stimulate T cell metabolism. He’s also working with existing immunotherapy studies to further modify the T cells so that their metabolism functions better in the tumor microenvironment.
Abstract (The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction. Nicole E. Scharping, Ashley V. Menk, Rebecca S. Moreci, Ryan D. Whetstone, Rebekah E. Dadey, Simon C. Watkins, Robert L. Ferris, Greg M. Delgoffe. Immunity; 08/02/16.)
The National Heart, Lung, and Blood Institute of the National Institutes of Health has awarded McGowan Institute for Regenerative Medicine affiliated faculty member Robert Parker, PhD, Professor in the University of Pittsburgh’s Department of Chemical and Petroleum Engineering, member of the Molecular Therapeutics/Drug Discovery Program at the University of Pittsburgh Cancer Institute, and a member of the Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center in the Department of Critical Care Medicine at the University of Pittsburgh, and, secondary Chemical and Petroleum Engineering faculty member Timothy Corcoran, PhD, a U01 Award. The Award work is entitled “Building Multilevel Models of Therapeutic Response in the Lungs.” The total amount funded will be $1.7M.
A U01 Award is a Research Project Cooperative Agreement. Details include:
- Supports discrete, specified, circumscribed projects to be performed by investigator(s) in an area representing their specific interests and competencies
- Used when substantial programmatic involvement is anticipated between the awarding Institute and Center
- One of many types of cooperative agreements
- No specific dollar limit unless specified in FOA
Congratulations, Drs. Parker and Corcoran!
As additive manufacturing, or 3D printing, continues to advance in industry and academia, knowledge gaps can appear as researchers push the technology to new limits. To solve some of industry’s most difficult additive manufacturing problems, Oberg Industries and the University of Pittsburgh’s Swanson School of Engineering have partnered to combine Oberg expertise in manufacturing complex tooling and precision machined or stamped metal components with Pitt’s ANSYS Additive Manufacturing Research Laboratory (AMRL). McGowan Institute for Regenerative Medicine faculty member David Vorp, PhD, Associate Dean for Research, Swanson School of Engineering, William Kepler Whiteford Professor of Bioengineering, Director of the Center for Vascular Remodeling and Regeneration, Co-Director of the Center for Medical Innovation, and Director of the Vascular Bioengineering Laboratory, is a member of the Pitt team.
Through the partnership with the Swanson School, for the next 2 years Oberg will have full-time employees on-site to manage technical excellence at the ANSYS AMRL. Dedicated in June 2016 at the Swanson School, the ANSYS AMRL is an additive manufacturing lab equipped with some of the most advanced additive manufacturing devices that utilize metals, alloys, polymers, and other materials to print components for nearly every industry. Oberg will promote the partnership to its customer partners to broaden corporate activity at Pitt while maintaining priority industrial access for its education, training, prototyping, testing, design, and production uses.
“This collaboration will link Pitt researchers in engineering, especially biomedical and aerospace, with Oberg’s remarkable fabrication expertise in medical, aerospace, energy, and industrial production,” said Mark Redfern, PhD, Pitt’s Vice Provost for Research. “We look forward to wider engagement of faculty experts and students through the collaboration and with Oberg.”
Oberg and Pitt’s collaborative work in this area was initiated with funding from the federal government via America Makes (the National Additive Manufacturing Innovation Institute). Pitt’s research includes the development and testing of new tools to optimize the design and construction of manufactured parts to improve strength, lower weight, reduce overall costs, and improve sustainability of production.
“The industry is rapidly changing as the technology advances, and customers are increasingly viewing Oberg as a partner to capture the advantages,” said David L. Bonvenuto, President and CEO of Oberg. “Through this partnership we’re connecting our customers to Pitt’s expertise in additive manufacturing and a state-of-the-art additive research facility. Together we ask better questions, we discover and learn more, which ultimately advances Oberg’s value to its customers in this new era of additive manufacturing.”
“The ANSYS AMRL is strengthened by this partnership with Oberg,” noted Albert To, PhD, associate professor of mechanical engineering and materials science and one of Pitt’s AM researchers. “The value we gain from Oberg who will manage the machines, help students advance their skills, and interact with industry to advance this technology, is phenomenal.”
Since 2014, additive manufacturing researchers at the Swanson School have attracted more than $6 million in grants from America Makes, the National Energy Technology Laboratory, the National Science Foundation, and Research for Advanced Manufacturing in Pennsylvania.
University of Pittsburgh School of Medicine researchers—including McGowan Institute for Regenerative Medicine affiliated faculty members Timothy Billiar, MD, George Vance Foster Endowed Professor and Chair in the Department of Surgery, and Derek Angus, MD, MPH, Distinguished Professor and the Mitchell P. Fink Endowed Chair of Critical Care Medicine—have demonstrated for the first time that changes over time in the volume of patients seen by trauma centers influence the likelihood of seriously injured patients living or dying.
The findings, reported online and scheduled for an upcoming issue of the journal Annals of Surgery, mean that changes in patient volume across all affected centers should be considered when designating a new trauma center in a region.
“It takes about three years for the impact of increased patient volume to translate into improved patient outcomes,” said lead author Joshua Brown, MD, MS, a research fellow in the Division of Trauma and General Surgery in the Pitt School of Medicine’s Department of Surgery. “Siphoning of patients through unregulated growth of unnecessary trauma centers can have a profound detrimental impact on patients that isn’t immediately obvious. Before designating a new trauma center, serious consideration should be given to how that designation will affect patient volumes over time at trauma centers throughout the region.”
Dr. Brown and his colleagues examined records of nearly 840,000 seriously injured patients seen at 287 trauma centers between 2000 and 2012. The centers averaged 247 severely injured patients per year, and 90 percent of the cases involved blunt injury. The researchers compared the expected death rate for each center if everything involving each trauma patient’s care had gone perfectly to the center’s actual death rate.
Each 1 percent increase in patient volume at a trauma center was associated with 73 percent better odds of a patient surviving. Conversely, each 1 percent decrease in volume was linked to a two-fold worsening in the odds of a patient surviving.
“So, the study suggests the negative impact of declining patient volume is significantly greater than that of the positive impact of increasing patient volume,” said senior author Jason Sperry, MD, MPH, associate professor in the Pitt School of Medicine Departments of Surgery and Critical Care Medicine. “Granting unnecessary designation to a trauma center in a region that doesn’t have the patient volume to support it not only hurts patient outcomes at that new center, but it will likely lead to a decline in patient outcomes at other nearby centers.”
Follow-up study will be needed to determine why patient volume is linked to patient outcomes, but the researchers suspect that as centers increase their number of patients, they also increase their resources, infrastructure, and experience. Although advances in care and diagnostics may be more readily adopted at higher-volume trauma centers, this alone did not explain the influence of trauma center volume changes on patient outcomes over time.
Abstract (Impact of volume change over time on trauma mortality in the United States. Brown, Joshua B. MD, MSc; Rosengart, Matthew R. MD, MPH; Kahn, Jeremy M. MD, MS; Mohan, Deepika MD, MPH; Zuckerbraun, Brian S. MD; Billiar, Timothy R. MD; Peitzman, Andrew B. MD; Angus, Derek C. MD, MPH; Sperry, Jason L. MD, MPH. Annals of Surgery; June 15, 2016.)
The National Institutes of Health (NIH) appointed Anne M. Robertson, PhD, William Kepler Whiteford Professor of Engineering, Director of the Center for Faculty Excellence in the Department of Mechanical Engineering and Material Science at the University of Pittsburgh, and McGowan Institute for Regenerative Medicine affiliated faculty member, to the Neuroscience and Ophthalmic Imaging Technologies Study Section at the Center for Scientific Review.
Dr. Robertson will serve a 4-year term as a NIH Reviewer from July 1, 2016 until June 30, 2020.
Dr. Robertson’s research is focused on cerebral vascular disease and mechanobiology, and she directs a multi-institution program on cerebral aneurysm research. She is principal investigator on a current R01 and two multi PI R21 grants from the National Institutes of Health and has held visiting research professorships at universities, including the Polictecnico di Milano (Italy), the Bernouilli Center at the Swiss Federal Institute of Technology (EPFL, Switzerland), and RWTH University of Aachen (Germany). Dr. Robertson is Director and Founder of the newly formed Center for Faculty Excellence in the Swanson School of Engineering (SSOE).
Congratulations, Dr. Robertson!
AWARDS AND RECOGNITION
Congratulations to Luai Huleihel, PhD, who won the Stimulating Pittsburgh Research in Geroscience (SPRIG) Scholar’s Pilot Project Award for his project entitled, “The Role of Matrix-Bound Nanovesicles from Old and Young ECM Scaffolds upon Macrophage Polarization.” This Award is in the amount of $10,000/year for 2 years. Dr. Huleihel works in the laboratory of McGowan Institute for Regenerative Medicine Deputy Director Stephen Badylak, DVM, PhD, MD, Professor in the Department of Surgery and Director of the Center for Pre-Clinical Tissue Engineering within the Institute.
Dr. Huleihel’s project is to identify MBVs embedded within old and young ECM scaffolds and their effect upon macrophage polarization, as well as to evaluate the effect of young and old ECM-microvesicles on the in vivo host response and remodeling potential in a rodent model of acute traumatic muscle injury.
The objective of the SPRIG Scholars Program is to provide multi-faceted support for graduate students and post-doctoral fellows through the establishment of four activities. The specific immediate goals of this program are to increase attendance at monthly seminars, build stronger collaborative research teams, and provide an exceptional environment of training and mentoring with an eventual goal to procure a T32 training grant in the biology of aging.
Congratulations, Dr. Huleihel!
The Regenerative Medicine Podcasts remain a popular web destination. Informative and entertaining, these are the most recent interviews:
#163 –– Dr. Marie Billaud is a Research Assistant Professor in the Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, and in the Thoracic Aortic Disease Research Lab of the McGowan Institute. Dr. Billaud discusses her research on thoracic aortic disease.
Visit www.regenerativemedicinetoday.com to keep abreast of the new interviews.
The Picture of the Month is a compliment to the longstanding features Grant of the Month and Publication of the Month. Each of these features highlights the achievements of McGowan affiliated faculty and their trainees. As we have always welcomed suggestions for grants and publications, please also consider submitting images that can highlight your pioneering work.
This is a 3D reconstruction of muscle bundles (green) and collagen fibers (red) done on the multiphoton scope. This sample is from Dr. Fabrisia Ambrosio.
Author: Hoffman B, Martin M, Brown BN, Bonassar LJ, Cheetham J
Title: Biomechanical and biochemical characterization of porcine tracheal cartilage
OBJECTIVES/HYPOTHESIS: The trachea is essential to respiratory function and is a mechanically and biochemically complex composite tissue. Tissue-engineering approaches to treat tracheal diseases require detailed knowledge of the native mechanical and biochemical properties of the trachea. Although the porcine trachea represents an excellent preclinical model, relevant mechanical and biochemical composition are incompletely characterized.
STUDY DESIGN: Experimental. The mechanical and biochemical properties of 12 intact porcine tracheas were determined to characterize their compliance, as well as the aggregate modulus, bidirectional elastic modulus, hydraulic permeability, and biochemical characteristics of individual cartilage rings.
RESULTS: Data demonstrate the glycosaminoglycan content of tracheal rings was (mean ± standard deviation) 190 ± 49 μg/mg. Hydroxyproline content was 8.2 ± 3.2 μg/mg, and DNA content was 1.3 ± 0.27 μg/mg, a four-fold difference between circumferential elastic modulus (5.6 ± 2.0 megapascal [MPa]) and longitudinal composite elastic modulus (1.1 ± 0.7 MPa, P < 0.0001) was also observed. Aggregate modulus (stiffness) of porcine tracheal rings was 1.30 ± 0.28 MPa, and inflationary compliance was 0.00472 ± 0.00188 cmH2 O(-1) .
CONCLUSION: This study presents a comprehensive characterization of the relevant biochemical and mechanical properties of porcine tracheal cartilage, which is considered an excellent candidate for xenogenic tracheal graft and a source for tissue-engineered tracheal reconstruction. The range of parameters characterized in this study agrees with those reported for hyaline cartilage of the airway in other species. These characteristics can be used as quantitative benchmarks for tissue-engineering approaches to treat tracheal disease.
Source: Laryngoscope. 2016 Oct;126(10):E325-31. doi: 10.1002/lary.25861. Epub 2016 Jan 30.
PI: Timothy Corcoran and Robert Parker
Title: Building Multilevel Models of Therapeutic Response in the Lungs
The goal of this research is to develop a series of interconnected models of therapeutic response in the diseased lung, focused primarily on cystic fibrosis (CF), that will ultimately provide a means for predicting in vivo response based on patient-specific in vitro testing, allowing for the optimization and personalization of therapies. Our center has an extensive history with the use of human bronchial epithelial (HBE) and more recently human nasal epithelial (HNE) cell cultures to study CF pathophysiology. We have also developed functional imaging biomarkers in the lung that provide organ level quantification of CF lung physiology (mucociliary clearance and airway liquid absorption). More recently we have developed in silico systems models of lung physiology at both the cell and organ level. The in silico models provide a framework of differential equations that describe how basic physiological processes interact and contribute to experimental outcomes. Their use allows these mechanisms to be more specifically differentiated. Here we propose to link in vitro and in vivo response by sampling and culturing human nasal epithelial (HNE) cell cultures from both non-CF and CF subjects who will also perform a series of physiological assessments, including functional imaging scans. Our in silico models will facilitate this linking of these models. We wil also retrospectively and prospectively survey clinical data from donors to determine which measures of cell and organ level physiology will predict the clinical course of CF lung disease.
PUBLIC HEALTH RELEVANCE: When developing new medications for lung diseases like cystic fibrosis, we depend on lab experiments using cells from the airways, physiology studies of how the lungs change when a drug is given and clinical studies that determine how drugs affect overall health. We want to develop computer models that will let us link the results of these different kinds of studies so that we can better predict how patients will respond to drugs by just doing lab studies on cell samples from their noses. This will allow us to develop medications more raTimothy pidly for all patients and also to personalize treatments for individual patients as well. I order to develop these computer models we will perform a series of tests on patients who have CF. This will include sampling cells from the nose and measuring their lung physiology using a combination of different imaging, breathing, and other studies performed both before and after they take a therapy. We will perform similar tests on people who do not have CF, and also studies on the parents of our CF patients who carry a single CF gene because this will provide us with information on how specific genes might affect CF lung disease. We will also look at the long term health of the CF patients and see what measured values predicted whether they became sick of stayed healthy. We will use the first half of our data to produce the computer models and the second half of our data to test their predictive accuracy.
Source: National Heart, Lung, and Blood Institute
Term: 09/01/16 – 06/30/20
Source: $457,382 per year


St. Paul’s Adult Choir is comprised of approximately 40 members, both professional and volunteer, who come from a variety of musical backgrounds. Membership is open to adults and high school youth. The full choir, or a schola (small group) sings at the 11:00 a.m. Holy Eucharist during the program year, in addition to once or twice monthly Choral Evensong. Two-hour rehearsals take place on Thursday evenings from September through May.
In recent years the Adult Choir has completed choral residencies at the Cathedral of St. John the Divine in New York (2010), Washington National Cathedral (2014), and St. Paul’s Cathedral in London (2017). In 2022 the choir traveled to England and sang services at Exeter, St. Alban’s, and Southwark Cathedrals (read about the trip).
2023-24 Choral Auditions. Requirements to join the choir are a strong commitment to the choir schedule, a basic knowledge of music, and a good ear. You do not have to be a member of St. Paul’s or the Episcopal Church to join.
Adult Choir schedule
Rehearsals and service appearances are occasionally rescheduled at short notice.


text:
Mere hours after of his announcing of his retirement, Yeo “TrAce” Chang-dong will be starting as a coach.
Samsung made the announcement on Facebook on Friday, that TrAce will be added to Samsung’s coaching staff. The post asked the fans to cheer him and encourage his new career.
Previously the top laner to the Jin Air Green Wings, TrAce made a name for himself inventive and unexpected picks in the top lane, also called the ‘Edison of LoL’ in Korea. Also one of the oldest at age 27, he still managed to stand up to younger talent on other teams.
TrAce did mention previously in his retirement post that he will be able to meet the fans in a different position, perhaps hinting of the appointment.


ANZAPLAN has uploaded two vanadium white papers to its website to help the mining community in understanding and build further knowledge on vanadium.
Vanadium is a specialty commodity that has a significant role in the steel alloys industry because of its ability to reduce weight, improve toughness, ductility, and strength to the metal. It is mostly consumed as vanadium pentoxide. Today, vanadium is a hot topic because of its use in the energy storage industry. Vanadium Redox Flow Batteries (VRFB) provides efficient, reliable and cost-effective energy storage.
There are several sources of vanadium in the world with vanadiferous titanomagnetite deposits being the most prominent followed by sandstone-hosted vanadium deposits. Other more unconventional vanadium deposits such as vanadium graphite schists/gneisses are under investigation to extract vanadium from the V bearing mica roscoelite.
Vanadium recovery processes will depend on the vanadium ore deposit. Several processes can be used to extract vanadium starting from physical processing to hydrometallurgical processing. Further refinement of vanadium pentoxide is an important step to achieve high purity vanadium pentoxide to be used in different applications.
Vanadium is mostly used in the steel and iron industry. It is also used in high value applications such as catalysts, aerospace and energy storage. The main use of vanadium in the growing energy storage industry is for vanadium redox flow batteries (VRFB).
Two vanadium white papers are now available for download. The first white paper covers vanadium’s occurrence, production, deposits and markets. The second white paper covers the different aspects of vanadium processing.
Please contact us, we will be happy to schedule a meeting with you to discuss opportunities of possible collaboration.


“Follow Your Passion.”
It’s either a mantra of success you’ve heard all of your life, or is a line that you’ve ingrained in your children and grandchildren for all of theirs.
Unfortunately, if you have told this to your children all their lives, you may have set them up for unhappiness due to forming unrealistic expectations of life in their heads, according to this article in the Huffington post titled “Why Generation Y Yuppies are Unhappy” by Wait But Why.
This article breaks down the mathematics of happiness in poignant, quirky illustrations, and shows us why many Generation Y Yuppies seem perpetually dissatisfied with their life circumstances. It argues that during the baby boomer era, young people weren’t promised much, but found themselves in a time of prosperity as they entered the career world – this is a scenario in which reality beats expectations, and people were consequently satisfied and happy. Today, Gen Y young professionals have been told all their lives that the world is their oyster, and that they can have anything they want if they really try for it, but instead are facing a much harsher and more mediocre reality than they expected.
Of particular interest to our current focus on social media depression is the section that discusses how this dichotomy between reality and expectations is further exacerbated by the “internet images” that are carefully crafted by friends, classmates, and acquaintances on Facebook and other social networks. The effect of social media image crafting is that people start to believe that everyone else’s reality is meeting their expectations except theirs, when in reality everyone else is on the same level of “normal” as the looker. This kind of constant social comparison can lead to self-criticism, anxiety, and FOMO effects, particularly in young adults and teens.
Here is an excerpt from the article below:
“Social media creates a world for Lucy where A) what everyone else is doing is very out in the open, B) most people present an inflated version of their own existence, and C) the people who chime in the most about their careers are usually those whose careers (or relationships) are going the best, while struggling people tend not to broadcast their situation. This leaves Lucy feeling, incorrectly, like everyone else is doing really well, only adding to her misery…”
Click here to read the rest of the article.
Parents, do you feel you painted an unrealistic picture of the “real world” to your kids? And Gen-Yers, do you feel that the world was not quite what you had hoped for as you enter adulthood? Tweet @birminghammaple or reply in the comments below!


text:
Ariel Sharon the Traitor
Ariel Sharon, the bulldozer general, prime minister and hero of Israel's Wars, has turned an about-face, becoming Israel's worst traitor. Sharon is now a modern day Benidict Arnold. Sharon, his sons and his political allies have given up some of MY inheritence in the land of Israel, and MY children's inheritence in their land of Israel. May Sharon rot in jail for his treason to the Jewish people of Israel.
In the United States, treason is punished often by long jail sentences. In the case of Jonathan Pollard, passing classified US gov. information on Iran's nuclear program to Israel got Pollard a life sentence. For Sharon's treason of uprooting 21 Jewish Gaza towns and ruining thousands of Jewish lives and thriving farm businesses, Sharon got President Bush's handshake and invitation to bbq at Bush's Crawford Texas ranch. So much for fighting terrorists in Israel. Giving Arab terrorists Israeli land is the biggest reward yet for Arabs who only know how to kill Jews.
On the 9th of Av we now have a new mourning and saddness. We Jews have a new kick in the head, for Sharon has kicked all Jews with a cheap shot. Ariel Sharon has given up on Jewish Gaza and parts of northern Sameria, in an effort to force a settlement of the Arab/Israeli war. Going against Israeli and Lukid party voters, Sharon, the bulldozer, is trying to give up large parts of Israel by destroying Jewish settlements and Jewish towns with intentions to do more 'painful withdrawals'. Withdrawal under fire from the ancient Jewish heartland of Judea and Samaria goes against millions of Israelis wishes and democratic votes. The nagging thought of Sharon doing all this to avoid jail time and stay in power keeps me wondering who is pulling Sharon's strings.
Sharon lied to everyone to get out of Gaza fast. Sharon's "No Retreat Under Fire" became exactly the opposite. With motars, kassam rockets, roadside bombs, shootings, and bomber belts found all coming from the 'peaceful Arabs' in Khan Yunis and other refugee camps, "Retreat Under Fire" became the nightmare reality, or the joke, depending on what side your on. Thanks to Sharon & Bush, the modern day Laurel and Hardey; in one week, Jewish Gaza has been turned from a paradise to a hell on earth.
Ariel Sharon's son, Omri, looks to do jail time soon, as Israel's Attorney General, Menachem Mazuz has said. "Omri Sharon is expected to be indicted on Sunday, facing charges of illegal election fundraising (bribes) in Ariel Sharon's 1999 Likud primary race for the party leadership. Efforts to reach a plea-bargain agreement with Omri failed when Attorney General Mazuz insisted the deal include jail time." Omri Sharon wants to take his chances with a criminal trial. Omri knows he can bribe judges and lawyers and he has a decent chance at beating the charges. The evidence shows that Omri was deeply involved in illegal campaign contributions, bribes, corruption, and illegal offshore business and real estate deals in the Greek islands.
Now that Sharon's retreat has finished pulling 10,000 Jews out of 21 beautiful, prosperous Jewish towns in Gaza and 4 Jewish towns in northern Sameria, the dogs of politics are calling for early elections. Peres, Beilin, Lapid and Sarid and others are calling for elections. Binyamin Netanyahu very much wants to become Prime Minister again. If I was a betting man, I'd bet Netanyahu will be our next Prime Minister. Sharon seems to be heading for early retirement to count Sheep on his farm, and it can't come too soon!!
I offer my heart felt sympathy and support to all my Jewish brothers and sisters of former Jewish Gaza and northern Samaria who have been illegally thrown out of their homes. This is a violation of thier human rights. The world would never tolerate evictions for Arabs, but evictions for Jews is OK. The world's silence is deafening.
The 'Wandering Jew' is now a reality again in 2005/5765. I never thought I would see the day that the 'Wandering Jew' would be played out again. It hurts even more that Sharon, whose whole life's work was to defend and build up Israel, did this to Torah loving Jews of Gaza and Samaria. Now the flood gates have been opened. The world's appetite has been whetted, and enemies of Israel now have a taste for more Jewish land to be given up. World leaders can heardly contain their glee at congrats to Ariel Sharon and his evil expulsion actions. Once again, its 'open season' on Jews.
Sharon's unilateral retreat from Gaza has made Jewish ownership of land, houses and property less secure all over the world. In the US, my hold on real estate I own here feels less secure. I feel it in the eyes of Jews I meet all over Chicago. I feel less secure in ownership when I visit my real estate in Florida as well. It's on the mind of more then a few people. I heard similiar thoughts echoed in services in a miami shul. Jews feel more threatened and less secure. Do gentiles think I as a Jewish landlord have less right to own real estate now? If Jews can be driven off land in Israel, do Jews still have a right to own our own land anywhere?
I pray to G-d that soon a real leader of Israel, a lover of Torah, be it Jewish man or woman, will be elected, such as Nadia Matar, Daniella Weiss, Beni Elon, Effie Etam or Moshe Feiglin to be prime minister of Israel. We need a real Jewish leader who knows our great history and our attachment to the land, and will lead our Jewish nation to G-d's destiny that Torah tells us we Jews will become. We must reclaim all Jewish real estate and own it directly and with honor and pride of ownerhship. We Jews must reclaim our holy Temple Mount which is the key to all of Jerusalem and Israel. To rebuild our holy Temple and be a light onto the nations for the power and honor of G-d.
Today Gaza has been abandoned to enemy terrorist Arabs. Tomorrow Sharon will be aiming for Judea and Jerusalem to be given up next. We must stop Sharon, as he has turned into an evil traitor. WE ALL must stop Sharon before he gives away the land of Israel that I love and I dream of making aliyah to soon.
"For Jerusalem's sake I will not be silent."


VMware unveils vCloud for NFV with Integrated OpenStack to accelerate service innovation
VMware, the global leader in virtualisation and cloud infrastructure, today debuted VMware vCloud for NFV, an integrated Network Functions Virtualization (NFV) platform that will combine VMware’s production-proven virtualised compute, networking, storage and management solutions with integrated OpenStack support. With support for more than 40 different virtual network functions (VNFs) from more than 30 vendors, VMware vCloud for NFV is the only platform available today that runs different VNFs from different vendors side by side on the same unified platform for the cloud. With vCloud for NFV, communication service providers (CSPs) can deploy NFV solutions into production on a proven platform to achieve faster time to market for new and differentiated services while driving sustainable cost reductions.
At Mobile World Congress, VMware CEO Pat Gelsinger will deliver a keynote address titled, “The New Mobile Identity” on Wednesday, March 4, 2015 from 9:15 – 10:45 a.m. CET in Hall 4, Auditorium 1.
Faced with declining margins and the need to accelerate service innovation, CSPs globally are embracing NFV to make their core network more agile and cost-effective. As the pioneer in virtualisation and cloud, VMware is engaging with CSPs to deliver NFV solutions today. The VMware vCloud NFV Platform features VMware vSphere, the industry-defining compute virtualisation solution for the cloud; VMware NSX, a full network virtualisation platform that delivers the entire networking and security model from L2-L7 in software; VMware Virtual SAN, software-defined storage that reduces storage CapEx and OpEx; and VMware vRealize Operations, an extensible cloud management solution which will deliver purpose-built management packs to meet the unique requirements of CSPs. The platform will include full OpenStack compatibility through VMware Integrated OpenStack.
“Vodafone chose VMware’s virtualisation infrastructure for our initial Telco Cloud services, and we have successfully been in production with several services,” said Kevin Salvadori, Director of Group Technology Strategy and Operations, Vodafone Group. “VMware was the solution for NFV that is ready for production across the different workloads we care about. As a result, we have been able to accelerate our time to market for new capabilities.”
“By moving Network Functions Virtualization into production today, our communications service provider customers, such as Vodafone, are accelerating their own transformation into next-generation cloud providers, building the operational expertise needed to succeed in the cloud era ahead of their competition,” said Shekar Ayyar, recently appointed corporate senior vice president, Strategy and Corporate Development and General Manager, Telco NFV Group, VMware. “Today, CSPs can deploy virtual network functions on VMware vCloud APIs, building valuable production cloud DNA into their operations and support teams. At the same time, they can begin to test OpenStack-based VNFs on the same infrastructure and deploy to production as OpenStack’s suitability for NFV use cases improves in future releases.”
VMware to offer fast and simple path to OpenStack
VMware vCloud for NFV will include VMware Integrated OpenStack, VMware’s fully-tested and supported OpenStack distribution. VMware Integrated OpenStack will offer a fast route to service innovation by combining the agility of OpenStack with the resiliency and maturity of VMware’s proven portfolio of best-in-class compute, networking, storage and management components. With VMware vCloud for NFV, CSPs will be able to take a phased approach to adopting OpenStack, and VMware will help CSPs drive increasingly greater value from OpenStack as the framework evolves to help them accelerate service innovation and reduce costs. The vCloud for NFV platform is available today, with VMware Integrated OpenStack scheduled to be available in the platform Q1 2015.
“We are seeing OpenStack momentum continue to grow across the CSP market as our customers seek to achieve greater agility, and to leverage Open APIs to support true multi-vendor NFV. OpenStack also supports the NFV objective of dramatically reducing infrastructure costs to address continued margin erosion,” continued Ayyar. “CSPs need an OpenStack distribution that is optimised for a mature NVFI platform that helps them get started today and carries them through tomorrow, and VMware will meet this need by offering customers a fast and simple path to OpenStack adoption.”