text:
These Mb21d1 (cGAS) knockout mice exhibit increased susceptibility to DNA viruses (murine gamma-herpesvirus 68 and vaccinia virus), and to West Nile virus. These mice may be useful in studies of host response to viral infection or the presence of DNA in the cytosol.
Herbert (Skip) Virgin, Washington University School of Medicine
The Mb21d1 gene encodes for a cytosolic DNA sensor cyclic GMP-AMP synthase that activates the TMEM173/STING pathway for type 1 interferon production. These mice carry a knock-out mutation for the Mb21d1 gene in which exon 2 (encoding the catalytic domain) has been excised. Reduced levels of gene product (mRNA) is detected by qRT–PCR analysis of spleen, lungs, and bone marrow-derived macrophages from homozygous animals. No cGAS protein is detected by immunoblot of skin fibroblasts isolated from knock-out mice. When challenged with DNA viruses, murine gamma-herpesvirus 68 and vaccinia virus, homozygotes exhibit higher viral titers and 100% mortality from vaccinia virus(compare to wildtype control 30% mortality). Homozygotes display increased susceptibility to West Nile virus infection.
To generate this knock-out strain C57BL/6NTac-Mb21d1tm1a(EUCOMM)Hmgu/IcsOrl mice were bred to mice expressing a nuclear localized FLPe recombinase under the control of the CAG, chicken beta-actin promoter and cytomegalovirus enhancer, (C57BL/6-Tg(CAG-FLPe)36Ito/ItoRbrc) to excise the lacZ and neomycin cassettes, leaving exon 2 floxed. The conditional mutant mice were then bred to B6.C-Tg(CMV-cre)1Cgn/J (Stock No. 006054) mice to excise exon 2. The resulting knock-out mice were bred to C57BL/6J mice to remove the Cre recombinase transgene.
Upon arrival at The Jackson Laboratory, the mice were crossed to C57BL/6J (Stock No. 000664) at least once to establish the colony.
|Allele Name||targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||cGAS; Mb21d1-|
|Gene Symbol and Name||Cgas, cyclic GMP-AMP synthase|
|Strain of Origin||C57BL/6N|
|Molecular Note||The L1L2_Bact_P cassette was inserted at position 78437955 of Chromosome 9 upstream of the critical exon 2 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 2 at position 78437075. The critical exon 2 is thus flanked by loxP sites. Flp-mediated recombination removed the beta-geo cassette and left exon 2 floxed. Cre-mediated recombination removed exon 2. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.|
When maintaining a live colony, these mice can be bred as homozygotes.
When using the cGAS KO mouse strain in a publication, please cite the originating article(s) and include JAX stock #026554 in your Materials and Methods section.


text:
IXD2 is an annual celebration that seeks to bring together individuals who share an interest in the digital craft, culture, and community. This event provides a platform for attendees to participate in a wide variety of workshops, talks, and networking sessions that are aimed at fostering collaboration and improving the skills of those who work in the digital realm.
During the event, participants will have the opportunity to attend workshops on various topics, such as user experience design (UX), customer experience(CX), and or anyone working in the digital space. The workshop and talks are designed to be interactive and engaging, providing attendees with practical skills and knowledge that they can apply in their work.
The speakers will discuss their experiences with cultivating community through craft and culture, celebrating community passions and influences, and how this has set them up for the future. The focus is on design and reimagining our legacy and embracing fresh faces for the future.
IXD2 is for anyone interested in the intersection of design, technology, and community building. Whether you are a seasoned professional or just starting out in your career, IXD2 has something to offer everyone who is passionate about the digital spaces. The opportunity to see peers in real life at IXD2 is an opportunity for attendees to connect with other like-minded individuals in the industry. You never know where these connections go next. You can reach out to exchange ideas, share experiences, and collaborate on projects.
The focus is on design and our legacy, to embrace fresh faces for the future. The speakers will discuss their experiences with cultivating community through craft and culture and how this has set them up to succeed.
About AIGA Detroit
AIGA Detroit has been a chapter of the national AIGA organization since 1986. The Detroit chapter has 325+ members with a network reaching out to the entire Michigan creative community including: designers, educators, art directors, web developers, printers, illustrators, photographers, artists and students. Through events, programs and initiatives, AIGA Detroit is demonstrating the value of design to businesses and the power of design in our culture. The Detroit Chapter is committed to the continued growth of an already vibrant, creative community and a rich design history here in Michigan.
About Jon Yablonski
Jon Yablonski is a multi-disciplinary designer, speaker, writer, and digital creator based in Detroit metro. His passion is for designing digital tools that empower people and augment their abilities in order to achieve their goals. He’s had the opportunity to learn and grow from a variety of challenges throughout my career — from e-commerce platforms, mobile apps and internal products to HMI systems within state-of-the-art vehicle platforms.
Reach out with questions, feedback, or just to say hello!

domain: artistic


text:
Executive Chef at Rail House Café
What is the concept of Rail House Café?
A modern, all-day café with a menu of unique signature twists to international favourites in an artfully designed space. The globally-inspired menu offers healthy choices for everyday dining alongside weekend indulgences.
What’s the signature dish?
Breakfast and brunches have been a key focus for us, with a menu of nine different ways to enjoy your eggs including our unique hybrid eggs benedict and burger dish – the ‘Burgerdict’– a poached egg atop a beef patty with special hollandaise sauce, on an English muffin.
What do you like about being in Victoria?
Our location in Nova Food means we’re at the heart of this burgeoning foodie hotspot in the capital. It’s exciting to be a part of Victoria’s regeneration and growing reputation as a destination rather than a place people travel through!
When did you know that you wanted to be a chef?
I grew up on a farm as a child in South Africa and went to boarding school during the week. Whilst at home on the weekend, I spent as much time as possible in the kitchen cooking with my mum and weighing out ingredients. I suppose this is what encouraged my passion for cooking.
What’s the most important thing you’ve learned in your career?
The one thing I have learnt to truly appreciate is the value of working closely with great suppliers to get the best possible produce into our restaurants.
Whose cookbook do you turn to again and again?
There are so many but Culinaria France by Andre Domine and Essential Cuisine by Michel Bras top the list.
Rail House Café, 8 Sir Simon Milton Square SW1E 5DJ; railhouse.cafe

domain: food


text:
Best Restaurants in Hampton Roads AreaOur favorites include some of this destination's best restaurants—from fine dining to simple fare.
Find the Beach Pub just a few blocks inland from the Virginia Beach strip. This restaurant is a combination of casual dining fit for families and a crowded bar packed with locals (even in the middle of the day). The pub sports a retro theme—prints and photos from the resort city's past line the walls. Of course, the specialty here is fresh Atlantic seafood with such favorites as creamy crab dip or crab cakes, fried flounder, and boiled shrimp, but the burger and fries also are a popular choice. For those who like Southern eats, try the country-style vegetables. Before the rooster crows, get here for breakfast—the pub is open early. The staff is young and friendly, and the T-shirts are a popular souvenir.
Mary's Restaurant has been a Virginia Beach favorite for breakfast and lunch for more than 40 years, and you'll find yourself eating alongside executives, surfers and tourists. This cozy spot offers such down-home Southern favorites as country-fried steak, barbecue and homemade soup. In addition there's always a rotating selection of daily specials. Desserts include a mouthwatering array of cakes and pies sitting on the counter under glass cake domes. Try the all-day breakfast, which includes the “Old Virginia,” homemade biscuits, omelets and pancakes.
Many come by land; others come by sea, mooring their boats to one of the docks at Chick's Oyster Bar. Arrivals may differ, but this destination is a fun and casual spot on the Lynnhaven Inlet. The views of the water and million-dollar homes are spectacular, and the people watching on Chick's open-air deck can't be beat. The bar is well known for its fabulous fried butterfly shrimp and its oversized steamer platters, but other favorites include fried flounder, crab cakes and the grilled catch of the day.
Coastal Grill in Virginia Beach is more than just a great neighborhood bistro— it's a place with a menu that locals love. Try the lamb with eggplant puree, the spinach salad with chicken livers in a deglazed-pan vinaigrette, the pepper-crusted tuna or the soft-shell crabs (in season). The side dishes change seasonally—the restaurant serves grilled corn in the summer and brown sugar-glazed butternut squash during colder months. The decor is understated, punctuated by butcher's paper over green tablecloths, bistro curtains and handsome artwork. Coastal Grill does not accept reservations, so expect a wait at peak times.
Nearby Restaurants to Try
Steinhilber's Restaurant has been family-owned and operated since 1939. This former country club occupies a prime spot overlooking the Lynnhaven River and offers nostalgic charm with its mahogany paneling, vaulted ceiling and a portrait of the restaurant's founder hanging over a stone fireplace. The signature dish is the fried fantail jumbo shrimp, but the delicious she-crab soup, grilled fresh fish, back fin crab cakes and steaks are other wonderful choices. For dessert, order ice cream—made by a small, local dairy—or the pecan pie. The staff is warm and constantly attentive. There is a large patio overlooking the river, which is fun in warmer months.
The Doumar family has run its orange and white drive-in in Norfolk since 1915. This joint's all about good eats and nostalgia— Doumar's Cones & Barbecue still offers carhop service. Flash your headlights to prompt a carhop to approach your driver's side window. The drive-in sits between downtown and the trendy Ghent neighborhood and serves up traditional Southern barbecue, burgers, french fries and old-fashioned soda fountain favorites. Try their specialty, the banana milkshake.
Bolivian sisters run Luna Maya Cantina , a small and hip eatery in Norfolk where fresh ingredients and great tasting food prevail. The restaurant mixes Mexican and South American cuisine, and the menu includes chorizo corn casserole, fabulous sweet and spicy beef tamale and shrimp burritos. All meals start with chipotle salsa and fresh chips, and Luna Maya's made-to-order guacamole and white sangria are must-haves. Pale orange walls strike a warm tone contrasting with the cool and sleek chrome bar.
Crackers Little Bar Bistro in Norfolk serves numerous tasty dishes in equally small, appetizer-style portions. It's the perfect menu for those who like to sample many tastes. The offerings constantly change, but you can always expect to find the tomato mozzarella stack, the fried dumplings, the petite beef filet and the daily fondue special on the menu. The s'mores pu pu platter is a fun and sweet way to end a meal. Cracker's also offers a great wine and beer list—don't miss reading the humorous reviews.
A small, brightly decorated spot in Norfolk, the No Frill Bar & Grill has a cozy neighborhood feel and a heated patio for chilly winter evenings. Chalkboard specials shine with creativity and fresh seasonal influences, and the daily menu lists sandwiches, salads, burgers, local seafood and house specialties. Try the award-winning ribs, the famous chili, some barbecue, the grilled portabellas or the wonderful Spottswood spinach salad, piled high with crisp apples, blue cheese and caramelized onions. Desserts are excellent here, too—order the Carnegie deli cheesecake or the multilayered carrot cake.
Todd Jurich's Bistro is located in a new tower in Norfolk's increasingly sophisticated downtown. The seasonal menu presents unusual and delightful combinations of local products from the region. Cuisine influences range from Tuscan to Thai—try the grilled tuna with wasabi mashed potatoes or the sophisticated crab sauté over Johnnycakes. The wait staff is smooth and professional with excellent knowledge of the large stock of wines, which are stored in the restaurant's glass-walled wine room.
See all the restaurants for this destination.
Hampton Roads Area, VA
AAA’s in-person hotel evaluations are unscheduled to ensure the inspector has an experience similar to that of members. To pass inspection, all hotels must meet the same rigorous standards for cleanliness, comfort and hospitality. These hotels receive a AAA Diamond designation that tells members what type of experience to expect.
Members save up to 10% and earn Honors points when booking AAA/CAA rates!Hampton Inn & Suites
200 Vincents Crossing. Smithfield, VA 23430
Members save 5% or more and earn Marriott Bonvoy™ points when booking AAA/CAA rates!The Westin Virginia Beach Town Center
4535 Commerce St. Virginia Beach, VA 23462
Members save 5% or more and earn Marriott Bonvoy™ points when booking AAA/CAA rates!Norfolk Waterside Marriott
235 E Main St. Norfolk, VA 23510
Save 5% or more when booking AAA/CAA rates plus earn bonus points with the AAA Preferred™ BWR ProgramBest Western Plus Holiday Sands Inn & Suites
1330 E Ocean View Ave. Norfolk, VA 23503
As a AAA member, you'll save even more. Your AAA Travel Agent will check to see if AAA Vacations is combinable with other AAA member benefits, plus cruise and tour past passenger discounts and benefits.


text:
They will be able to recover weapons and other objects that will facilitate their progress in equally hostile environments. Minecraft Dungeons tried to be so much like diablo 3 it even copied the launch issues.
In our community of millions someone is always ready with fresh inspiration and news of the latest creations and releases.
How big is minecraft dungeons on pc. With Minecraft Dungeons it seems that an assumption a poor one was made for users who install the app to a custom directory. The developers came up with this new succession called Minecraft. Not being able to see cutscenes unless youre the host sucks.
CDKeys GreenManGaming Minecraft Dungeons is part of Xbox Game Pass an ever. Minecraft Dungeons file size. As the millions of Minecraft fans descend upon their new campsite a common question has emerged how do you.
Battle new-and-nasty mobs across action packed levels in either single player or up to four-person co-op multiplayer in this epic quest to defeat the evil Arch-Illager. Windows 10 PC – 271 GB. Minecraft Dungeons is Mojangs hack-and-slash adventure set in the Minecraft universe where youll travel through levels cutting or spellcasting your.
And while cross-play is not available at launch developer Mojang has confirmed this will be coming in the future. Fight your way through an all-new action-adventure game inspired by classic dungeon crawlers and set in the Minecraft universe. Please help the Minecraft Wiki clean up this page if you can.
Lets cut right to the chase and look at the Minecraft Dungeon file size. If you purchase the Minecraft Dungeons Launcher version of the game you will have to access the game through the Minecraft Dungeons Launcher. The logic given to the app was to assume that the folder containing the game files had nothing else in it.
Find a new perspective. Minecraft Dungeons Download free game for PC now. Save on Xbox Game Pass PC at the following retailers.
It is a smashing blow to construction games. Battle new-and-nasty mobs across action-packed treasure-stuffed wildly varied levels all in an epic quest to defeat the evil Arch-Illager. Developed by a dedicated passionate team at Mojang Minecraft Dungeons is a brand-new action-adventure title set in the Minecraft universe inspired by classic dungeon crawlers.
Up to four friends can play together or you can brave the dungeons alone. If you buy Minecraft Dungeons on the Microsoft Store for Windows 10 you will also need to play through the Microsoft Store. The gameplay is OK but with a laggy host youre bound to have spots where you cant move and youre just made to watch yourself get bashed up.
Minecraft Dungeons is an action-adventure role-playing video game developed by Mojang Studios Xbox Game Studios and Double Eleven. Controls should be verified and new controls should be added once the game releases on all platforms. How to Get Minecraft Dungeons Free Key to Download Xbox One PS4 and PC.
Its the same great game either way you decide to purchase it. It is ideal to always create a separate folder for every game that you install and thats what led to the bug. Xbox One – 254 GB.
Heres what you need to do to enable cross-play for yourself. Minecraft Dungeons continues the Minecraft mantra of play anywhere with anyone by being available on Xbox PlayStation Switch PC and even Xbox Cloud Gaming Project xCloud as. No matter which platform you choose to play on the Minecraft Dungeons file size weighs in at under 4 GB.
The talk page may contain suggestions. This succession of Minecraft offers a new genre. The odd spin-off title Minecraft Dungeons has finally arrived bringing blocky dungeon crawling action to PC Xbox One PlayStation 4 and even the Nintendo Switch.
Minecraft Dungeons now has cross-play letting anyone on Xbox Windows Switch and PlayStation all play together in harmony. In addition the presentation of the page should be cleaned up. DLC for Minecraft Dungeons.
Besides that there is a good game somewhere in this. Minecraft Dungeons is also set to release on the PS4 on 26th May. Players will be guided to explore dungeons where they will meet face-to-face with their enemies but not only.
Challenge yourself and your crew with new missions mobs gear and more. The popularity of Minecraft today is massive. Fight your way through an all-new action-adventure game inspired by classic dungeon crawlers and set in the Minecraft universe.
Make sure youve got your keybindings and other settings as you like them before starting a mission because currently the game doesnt seem to pause even in offline. Please note that if you purchase the game on the Microsoft store you will also need to access and play your game through the Microsoft store. Up to four friends can play together or you can brave the dungeons alone.
Battle new-and-nasty mobs across. It was released on May 26 2020 for Windows Xbox One Nintendo Switch and PlayStation 4 and on November 10 2020 for the Xbox Series XS3 Originally conceived as a game for the Nintendo 3DS16 Minecraft Dungeons takes inspiration from classic dungeon. Minecraft Dungeons is part of Xbox Game Pass PC an ever-growing catalogue of over 100 games that is a great way to try a whole smorgasbord of games including day one access to all Microsoft first party titles for just a few dollars a month.
Venture deeper into Minecraft Dungeons with downloadable content. Nintendo Switch – 360 GB. Is a Action Adventure game developed by.

domain: game


text:
The Waterloo Community Center at 3 Oak St. will join the Macedon Public Library, Clifton Springs Library and other sites offering Finger Lakes Community College’s 14-week job training classes in manufacturing, residential electric and health care in January.
FLCC began building a network of community education sites a year ago as part of a national pilot project to overcome barriers to education in rural areas, such as lack of transportation and broadband.
Classes can be taken online at home or, for those who lack broadband or computer equipment, at seven community sites across Ontario, Seneca, Wayne and Yates counties.
Grant funding is available for most participants because the courses prepare people for jobs currently in high demand.
“Grant funding is key because people can use these programs to upgrade their skills without debt,” said Todd Sloane, FLCC director of workforce development.
FLCC was one of five colleges across the country to receive funding from a Washington, D.C.-based nonprofit, Education Design Lab, to develop and test models for delivering education and training in small towns and villages.
A national trade publication for the concert and live music industry has ranked the Constellation Brands-Marvin Sands Performing Arts Center (CMAC) one of the top-selling amphitheaters in the world.
CMAC ranked No. 1 on the Pollstar list for top-selling amphitheaters in the Northeast, No. 8 for amphitheaters in the United States and No. 10 in the world.
The rankings were based on ticket sales from Jan. 1 through Sept. 19.
Ringo Starr, Kenny Chesney, Luke Bryan, Journey, James Taylor, The Black Crowes and Jackson Browne were among the performers during CMAC’s 20-show season of 2022.
“I’ve performed at CMAC seven times, and each time I’m amazed by how they run their venue, the energy of the fans, and the hospitality from the team,” Bryan said in a CMAC news release. “I always look forward to playing there — they’re definitely doing something right.”
Finger Lakes Community College celebrated on Thursday the opening of the $7.2 million Sands Family Center for Allied Health, a renovation and expansion of its nursing wing on the main campus.
With the expansion, the college will accept new students in both the fall and spring semesters. The application for the spring 2023 semester is currently open through Oct. 15. FLCC will also launch a licensed practical nursing program, starting in fall 2023.
“The Sands Family Center for Allied Health reflects a true team effort among the Sands Family Foundation, Thompson Health, Ontario County and the college,” said FLCC President Robert Nye. “We were united in our mission to fill a critical community need for nurses at our hospitals, medical offices and skilled nursing facilities.”
Richard Sands, representing the Sands Family Foundation, joined college and community leaders for the ceremonial ribbon cutting. The Sands Family Foundation contributed $3 million to the project.
“As important as today’s ribbon-cutting is, I am already thinking about the impact this center will have on our community,” Sands said. “Five years from now, hundreds of students will have passed through these halls and taken their places in our medical facilities where their compassion and skills are so needed.”
In addition to the Sands Family Foundation donation, the FLCC Student Corp. contributed $250,000; the FLCC Association, $200,000 and the FLCC Foundation, $200,000. New York State provided $3.6 million in matching funds to all the private contributions. Thompson Health will contribute an instructor for the licensed practical nursing program.
The project began with a renovation of existing space to add enhanced simulation labs. The expansion added an additional simulation lab and more patient bays to serve an increasing student population.
The new facilities complement a revised curriculum that focuses on clinical judgment and critical thinking, college officials said.
After the work began, the college received a $1.5 million state workforce development grant to add an additional science lab by mid-2023.
Ontario County, the local government sponsor of FLCC, hired PLAN Architectural Studio of Rochester to provide architectural and engineering services and LeChase Construction Services of Rochester to provide construction management. The county awarded the general contracting bid to G.M. Crisalli & Associates of Syracuse, the electrical bid to Connors-Haas of Ontario and the plumbing bid to Postler & Jaeckle Corp of Rochester.
Clark recently retired as vice president for Constellation Brands, the global beverage company started by the Sands family. She had a 20-year career with Constellation, serving as vice president of corporate communications and of external affairs during her time there.
Working for Constellation, Clark spearheaded some of its philanthropic efforts, such as the loan of company corporate jets to bring workers from InterVol, a humanitarian organization, to Haiti after the 2010 earthquake, and a $5 million capital campaign for Mercy Flight Central. She also oversaw construction of the NY Kitchen, and the Constellation Brands Marvin Sands Performing Arts Center on the FLCC campus. She remains the president of the boards of directors for both those organizations.
Clark is a community college graduate, having earned an associate’s degree from Herkimer County Community College. She also holds bachelor’s and master’s degrees from Rochester Institute of Technology.
Star Cider started out in the basement of a young couple’s home. But their dream to turn hard cider-making into a family business quickly outgrew that house in Clifton Springs, Ontario County.
So Cortni and Adam Stahl traded their house for an Airstream trailer parked next to a garage-size building in Clifton Springs, where they’ve been making up to 5,000 gallons a cider a year.
Three years later, the Stahls and their dog are living in a house again — this time in Canandaigua, and selling their cider in approximately 35 bars, restaurants and breweries, mostly in the Finger Lakes area. And the couple is ramping up once more. Star Cider was recently accepted into the state’s Start-Up NY program, which provides tax incentives for startup companies that locate on or adjacent to the 64 public college campuses in New York.
In this case, the Stahls will keep their headquarters in Clifton Springs, but build a production facility on property next to Finger Lakes Community College in the town of Canandaigua.
Partnering with the college and being helpful to the economy on a larger scale attracted the Stahls to the program, said Adam Stahl. They also liked the tax incentives that come with being part of the Start-Up NY program — no income taxes for employees nor sales tax charged to customers.
The company currently consists of three people — the couple and Adam’s brother, Nathan — and all three have day jobs. Though the Stahl brothers grew up on a farm where cider-making was a tradition that survived the Prohibition era, it is Cortni who has the professional connection to their venture. She works for the Cornell Cooperative Extension, performing analysis of wine, cider and beer and spends about half her time leading workshops for producers.
The Stahls are involved in every part of the cider process for their business, “from apple to glass” as Cortni said.
“We have to have that connection,” she said of picking the apples. “We can’t remove ourselves from that part of the equation.” Most of the apples are picked at Seneca Orchards, also in Clifton Springs.
Finger Lakes Community College is hoping for the same hands-on experience for its students, said Kal Wysokowski, director of grants for FLCC.
“We’re looking at some hands-on workshops in things like apple grafting or apple pruning, research projects, internships, studying the composition of the cider, trying out new recipes and having students do new activities.” Wysokowski said.
“This is primarily an education and research operation in the startup program. Although there will be a tasting area at the cidery, she said, “it’s really about the manufacture of cider.” Star Cider will be the fourth Start-Up NY company attached to FLCC and the only one involved in food and beverage processing.
Currently 38 of the state’s 64 public colleges campuses participate in the program, said Jeff Boyce, director of economic development at SUNY Research Foundation.
“If you think about the program, it’s touted as a tax-incentive program. It’s meant to stimulate job creation and investment,” Boyce said. But the benefit to campuses is that faculty, staff and students work with companies in the areas of research and innovation.
Star Cider’s proximity, on the grounds of the former Lincoln Hill Inn, will provide easy access for students, Wysokowski noted.
“They have some big plans. We’re really pleased to be a part of it. I think the students at FLCC are really going to see a benefit here.”
The Stahls are looking forward to having more room to expand operations. They will be seeking financing to build on the leased property soon and are in the process of gaining the necessary town approvals to build a barn-like production facility. If the approvals go according to plan, they’ll start construction in the summer and hope to capture the harvest season so they can produce cider there in the fall, opening for tastings by year’s end.
“I think the Finger Lakes are perfect for cider making,” Cortni said. The wine industry has already led the way, Adam said. “We see this as planting the seed for what we could do for cider.”
Oh, and about that name, Star Cider? Cut open an apple horizontally and you’ll see its genesis.
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.

domain: news


MacGregor Partners, LLC formed a strategic partnership with Swisslog North America, Newport News, Va.
“We are excited to partner with an industry leader like Swisslog and share the combined vision of a strategic partnership, beyond the traditional staff augmentation models that have historically limited the value in implementation and consulting vendor partnerships within the supply chain industry,” says Jason Ziegler, president and managing partner of MacGregor Partners. “Combining MacGregor’s top-tier consulting resources and our extensive implementation experience with Swisslog’s existing solutions and capabilities, we created a strong partnership that is the foundation for future industry-leading collaborations that we see our clients demanding, as they look for full-service supply chain firms to partner with.”
Headquartered in Raleigh, N.C., with development and customer service teams in Milwaukee, Wis., MacGregor Partners provides solution consulting and implementation services in the warehouse management and warehouse execution space. MacGregor Partners also developed cloud-based software solutions, including analytics and document management software catered to the supply chain market.
Matt Toburen, vice president of distribution solutions and innovation, will head up the Swisslog partnership for MacGregor.
“This is an exciting partnership for MacGregor, as it expands our offerings across the distribution landscape and provides Swisslog with an implementation partner that possesses domain knowledge, software and development expertise and a track record of successful implementations,” adds Toburen. “We are excited to bring MacGregor’s supply chain and software expertise to the table to help support such a strong player in the industry, Swisslog, as they experience tremendous growth and success in their industry. As the industry continues to look for innovative ways to drive down cost and reliance on a shrinking labor market, this partnership positions MacGregor to help current and future customers leverage the automation technology and solutions that Swisslog has available.”


text:
The Nigerian National Petroleum Corporation, NNPC, has disclosed that petrol subsidy regime is still in place.
This disclosure was made on Monday by the Group General Manager, Crude Oil Marketing, NNPC, Mr. Mele Kyari, at this year’s Oil Trading and Logistics Expo, OTL, taking place in Lagos.
Kyari said that the current petrol price was unrealistic. However, he opined that attempt to increase it would be met with stiff opposition by the public.
He said: “I also know today that it is impossible for this government to announce tomorrow that petrol is about N150. This government cannot sustain it. That is the truth. The people will not accept that figure.
“Today, we are in subsidy regime, absolutely. There is no way you bring product today and sell at N145 and get back your money, and make profit. That is not possible. You can see some marketers saying that fuel is N138.
‘’It is because they did not import. Somebody has taken the heat off the price. Because we (NNPC) have taken the heat, and you buy from us; you can afford to go to the market and then put a ridiculous price. It is not possible, because they did not import it.”

domain: economics


John Francisconi, the general manager of Bank Square Books in Mystic, Conn. Is finishing up a three-week residency at Otherwise Bookshop in Rome. The residency was made possible by Bookselling Without Borders (BWB), the collaborative program between 13 independent publishers that organizes fellowships for booksellers to attend international book fairs around the world.
Otherwise Bookshop is a tiny English-language bookstore that is a collaboration between Roman bookstore Altroquando and the Italian publisher Edizioni E/O, the owner of Europa Editions in the U.S. Reflecting on his experience, Francisconi said, “Generally speaking, it doesn’t feel a whole lot different from, say, moving from one bookstore to another in the U.S. There’s a till that needs counting, books that need to be received and shelved, phone calls to be answered.”
Despite the similarities in the day-to-day, Francisconi said “the difference in culture/place is, unsurprisingly, profound,” and added that there’s a constant feeling of “dislocation, the rug constantly being pulled from under my feet, and all the unpredictable amazements of everything in this city — it’s hard to put words to, but it’s already been one of the greatest gifts of my life.”
As for his impression of Italian bookselling, he said that the Italians too have to deal with low profit margins and difficult terms and discounts— 40% from the distributor Bertrams and 35% from Penguin UK. And fellow booksellers confirmed to Francisconi that developing a career in bookselling was itself a challenge, much as it can be in the United States.
Amazon, unlike in the U.S., was seen as less of a threat to bricks-and-mortar stores; In Italy, Amazon is limited to offering a maximum discount of 15% and legislation is being considered to limit that to 5%, as it is in France. He added that there is also a larger diversity of voices available to Italian readers. “Walk into a place like Altroquando, or Feltrinelli, and [you] see so many kinds of writers, from all over the world, in their original languages or in translation. It’s a completely different approach to bookselling.”
Still, one thing remains very much the same: handselling. “Yesterday, I handsold a copy of Sing to It by Amy Hempel,” said Francisconi, “[I] was thrilled to share with the customer stories about seeing Amy read and speak in Cambridge, when I was a student there. We also talked about her editor, Gordon Lish, a postcard pen-pal of mine. The customer had studied with Amy in the 1990s, and adored her teaching style. It could’ve so easily happened in Mystic, if he was passing through there, but how much better here in Rome!”
The next Bookselling Without Borders program will take three booksellers to the Frankfurt Book Fair in October. These are Jonathan Woollen from Politics and Prose in Washington, D.C.; Lesley Rains from City of Asylum Bookstore in Pittsburgh; and Chris McDonald from Bear Pond Books, Montpelier, Vt. In January 2020, Arsen Kashkashian of the Boulder Book Store in Boulder, Co.,will start a residency with Seagull Books in Kolkata, India.


Can growing energy demands be met safely and efficiently?
My talk today is about energy especially about energy demands. What is energy? In physics, energy is defined as the capacity to do work. This capacity is very important to our daily lives, business, and education and even for the national security. This is why it is so important for world to meet the growing demands of the energy. According to Global future studies & research stated that there are 1.3 billion people are living without electricity today, which is 20% of total population and that 2 billion of population, is expected to be added to world population between now and 2050. Moreover, countries like BRICS (Brazil, Russia, Indonesia, China, South Africa) under rapid growth of economic conditions raise the apprehension of that world might not able to meet the growth of the energy demands. This has been proven by the statement from International Energy Agency “The center of gravity of global energy demand moves decisively towards emerging economies – they account for more than 90% of net energy demand growth to 2035.” (IEA) This led us to a conclusion that it is a fact that world is going to face the complex challenges in energy sector, especially developing countries that experiencing expand of population this will demand another billions of population and moreover as country developed their living standard will be improve which will more intensify the problem of the lack of energy demands. On top of that, meanwhile the supplies of conventional oil and conventional gas are expecting to be declined in near future (OECD) Meeting those challenges might require changes in fundamental issues such as changing patterns of energy production, consumption, policies and son. From now I will going to discuss about whether it is possible to meet the growing energy demands or not.
For the purpose of this paper I will define two key terms to develop this paper.
• Energy demands: the total energy used by all of human civilization.
• Safely and efficiently: to expand energy supplies in a way that is safe, secure, affordable and environmentally responsible.
Yes, it is possible to meet growing energy demands in safely and efficiently.
Firstly, the world has to focusing on public private partnership to meet the growing demands of the energy. IEA calculated that it will cost $38 trillion to meet all energy demands for the world between now and 2035. (Lananh Nguyen & Tara Patel, 2011) This article suggested that order to meet the growing of the energy demands the $16.9 trillion will need to be spent on power-generation infrastructure through 2035. This is the place where the importance of private sector’s participation coming through. The private sector is the main engine for economic growth and development. Though PPP, it can bring additional funds to the on infrastructure it need it as well was technical and managerial experiences from the private sectors. Therefore, the partnership between private...


text:
Can the Yankees avoid the missteps of the Red Sox and Mariners?
Sometimes, The Runner Stumbles
But, what were the M’s to do? They had already invested heavily in King Felix, Robinson Cano and Nelson Cruz, all through at least the 2018 season. That was their original window, and it is now closing.
And that is partially because they faced a two-headed monster the last two seasons: As their offense has struggled to find an identity, their pitching has continued to regress.
Their King has continued his rapid and unexpected decline, last year pitching to a 4.36 ERA; he is no longer one of the best pitchers in baseball.
And even though James Paxton blossomed into a dominant pitcher, and is now Seattle’s worthy candidate as best pitcher in the AL, his 2.98 ERA performance was sandwiched between those of two much worse pitchers.
Ariel Miranda and Yovani Gallardo, along with Paxton, led the team in games started. But Miranda posted a 5.12 while Yovani threw up a 5.72. And with all due respect to Willie Nelson, one night of love don’t make up for two nights of hate.
No, the answer should have been to go all in.

domain: sports


text:
Last year’s auction raised R772 000, with artist Kirsten Sims’s board having fetched the highest price at R130 000, which is still the auction record for an individual artist’s work.
The auction is part of the 15th annual Wavescape Surf and Oceans Festival, which is showcasing a bumper line-up of ocean-conscious events at some city beaches and venues until Sunday.
Up to 250 surfing and art community patrons attended the auction, where artist Andrew Sutherland’s double-sided board, depicting a night sky, went for R105 000 on Thursday.
The second-highest-priced board was Kirsten Beets's artwork, which went for R102 000 and depicted minutely-detailed people swimming and wading in the ocean.
The third-highest priced board, at R100 000, was Lionel Smit’s sketchy profile of a large female face.
Other artists and their sold artworks include Ruby Swinney (R85 000), who created a bright turquoise board, which showed a shark caught in the tendrils of a jellyfish and a turtle painted in the likeness of Yoshi - a rehabilitated turtle recently released from the Two Oceans Aquarium after 20 years.
After Swinney came Brett Murray (R70 000), 9 Miles Project youths (R70 000), Paul Senyol (R65 000), Sue Williamson and Chris Slabber (both R46 000) and Rwandan refugee and former car-guard Eric Karangwa (R33 000).
Then came Chris Soal (R36 000) and Swain Hoggervorst (R24 000). All proceeds from the auction will benefit ocean organisations.


text:
LIFE TTGG Partner: OrIGin
The LIFE TTGG project “The tough get going” was co-funded by the European Environment and Climate Action Programme (Life 2014-2020). The objective of the project is to orient the development of the dairy sector towards an improvement in the production process efficiency, in order to guarantee its growth and preserve quality in the perspective of environmental sustainability.
In order to achieve the objective of improving the efficiency of the whole European PDO hard and semi-hard cheese production chain, the project involves 7 highly qualified partners: Consorzio tutela Grana Padano, Politecnico di Milano, Università Cattolica del Sacro Cuore di Piacenza, Fondazione Qualivita, oriGIn, Enersem and CNIEL.
Among these, oriGIn is the global alliance of Geographical Indications</strong> (GIs) from a large variety of sectors, representing today some 600 associations of producers and other GI-related institutions from 50 countries. oriGIn advocates for the effective legal protection and enforcement of GIs at the national, regional and international level, through campaigns aimed at decision-makers, the media and the public at large. oriGIn promotes GIs as a tool for sustainable development for producers and communities and facilitate the exchange of best practices.
Thanks to its international network, oriGIn participation in the LIFE TTGG project will facilitate the transfer of results to GI Groups and contribute to raise public awareness on the project outcomes to improve the supply chain efficiency and use of resources to respond to the challenges associated with sustainability. In particular oriGIn will:
• Facilitate data collection on production processes and environmental strategies
• Organize meetings with GIs producers and stakeholders at national and EU level
• Carry out communication and dissemination activities, including online events

domain: geography


Evangelist Angela Johnson and Minister VaShaun Mosby have partnered their ministeries to create, Private Conversations of a Mother & Daughter which is a real life glimpse of what happens behind the scenes of ministry. Stay tuned for updates concerning the broadcast on blogtalkradio.com/vashaunmosby.
Sorry we couldn't complete your registration. Please try again.
Please enter your email to finish creating your account.
Receive a personalized list of podcasts based on your preferences.


text:
Jump to navigation Jump to search
09.30.11 build 2100.201109290250.1
In addition to the patch notes below, a number of changes were made to address stability issues.
- Updated the error messaging for players who are unable to run the City of Heroes client due to missing OpenGL drivers.
- Addressed a Supergroup base editing issue in the Mac client.
Praetorian Level Restriction
- Praetorian characters on Free To Play Accounts should no longer have a chance to run into a level cap after level 14.


Prince Harry told to 'drop titles' and 'become US citizen' if he wants to voice opinions
By Mirror | January 31st 2021
Prince Harry should "drop all his titles" and become a US citizen if he wishes to have the "freedom" to voice political opinions, a royal expert has said.
The Duke of Sussex spoke out against the Capitol riots in Washington, which took place just two weeks before Donald Trump conceded to Joe Biden.
He called out for reforming social media after the deadly events and described the storming of "a literal attack on democracy."
The Royal added that there is "no way" to "downplay" organised "violent extremism" on social media.Royal author Angela Levin said Prince Harry should "droll all his titles and take American citizenship" if he wishes to have the "sort of freedom" that allows him to speak on political matters.
She told Express.co.uk : "If he wants this sort of freedom he should drop all his titles and take American citizenship.
"Of course having his titles has enabled him to do various lucrative deals but he can’t or shouldn’t have it both ways.
"I think Harry’s decision to lecture anyone on how to live, what to do and who to vote for is a misjudgement.
"And even more so in the United States."
Ms Levin added that Prince Harry should especially not speak out as "a member of the Royal Family" who is still "using" his Royal titles.
The idea of members of the British Monarchy not speaking out stems from the long-upheld tradition of staying non-partisan while carrying out their duties.
Rumours over whether the Duke of Sussex will take up American have swirled since he moved to California with his wife Meghan Markle in March 2020.
Meghan reportedly cancelled her plans to become a UK citizen after the move, as there is "no reason" to pursue the application.
A source reportedly told the Daily Telegraph the process was "quietly" dropped after the move.
It has been over a year since the couple made the decision to remove themselves from the Royal agenda and seek a new life.
The Queen gave Prince Harry and Meghan a year-long grace period that would have seen them back in the UK if it were not for the coronavirus pandemic.
Jubilee’s Joseph Githinji wins Muguga ward by-election
- Fugitive cop Caroline Kangogo found dead at her parents’ home
- We believe in God and the hustler nation, says UDA's Njuguna Wanjiku
By Too Jared
- The tight contest that was Kiambaa
By Brian Okoth
- President Uhuru condemns killing of environmentalist Joanna Stuchburry
- Kiambaa contest between Jubilee and UDA tight as results stream in
By Brian Okoth


text:
Careers in Behavior Analysis
We take our commitment to students seriously, honoring the Simmons promise to put you first. The Career Education Center (CEC) helps graduate students assess your skills and interests and explore your professional options and provides a full range of services to assist you in doing so.
Among these services, the CEC provides tailored career coaching to help you launch your career. Your career coach will help you clarify your career goals and help with developing the skills and strategies to attain them upon graduation from your CAS program. In preparation for your job search, we will assist you with analyzing, articulating and packaging your academic and work experience to effectively market yourself to employers. In addition, you will receive support in planning and implementing your job search strategy to make informed, effective decisions for your next step as well as future career transitions.
Career Programs and Events
In addition to individual career coaching and the other services outlined above, the CEC provides both on- and off-campus recruiting events and career fairs during the academic year. In addition, the CEC offers skill-building workshops on a range of career development topics such as "Getting Started on LinkedIn," "Professional Networking 2.0," and many more. Check out the CEC Events Calendar for the latest workshops and recruiting events.
- Beatley Library Art & Music Careers Guide
- Beatley Library Communications, Media, and Journalism Careers Guide
- Beatley Library Education Careers Guide
- Beatley Library Literature & Writing Careers Guide
- Beatley Library History Careers Guide
- Beatley Library Library & Information Science, Archives Careers Guide
- Beatley Library Women's & Gender Studies Careers
CEC Career Toolkit
- CEC Career Toolkit - visit the Career Toolkit for in-depth information across all the developmental career steps, including self-assessment, career exploration, resumes and cover letters, networking, interviewing, and managing your job search
- The Simmons Network is exclusive to Simmons University alumnae/i and students.
- LinkedIn - create your own account on the leading site for professional networking. Once registered you can join the Simmons LinkedIn Group
Resumes and Cover Letters
From CEC Career Planning & Resources
Job Search and Postings
- Handshake - Simmons' online job board, with approximately 1,000 active listings and 50 new listings each week
Our Students Go On To:
- Boston Public Schools
- The May Center - Randolph, MA
- Maynard Public Schools - Maynard, MA
- Nashoba Learning Group - Bedford, MA
- RCS - Natick, MA
- Simmons University
- Tufts University
- University of Massachusetts, Amherst

domain: library