text:
It’s rare that you find an album that makes you hate the people who wrote it, while simultaneously wanting to be their best friend. This is exactly what Major League’s There’s Nothing Wrong With Me does. As a product of earlier years of pop-punk, I have high expectations for sophomore albums, and I am so glad to say this one doesn’t disappoint.
Major League is back with their original guitarist Brian Joyce taking over as lead vocalist, and still consisting of guitarist Matt Chila, bassist Kyle Bell, and drummer Luke Smartnick. These four boys came out with an album that not only tugs at the heartstrings, but follows up their debut album with a more advanced and mature sound, without straying too far from their roots.
“Wallflower” opens the album with a perfectly classic pop-punk feel. What’s so refreshing about it, and the rest of the album in general, is the lyrics. They’re all too powerful right from the start, and honestly, it’s everything you’ve been looking for from Major League. It goes directly into “Graves”, which is a perfect follow up. It has a gritty and rough feel that you can’t and don’t want to get out of your head. Between the intense drums, and Joyce’s powerful statements, it’s a fighting song, and one we won’t soon forget.
“Pillow Talk” opens with beautiful guitar riffs that are still buzzing in my brain. Joyce’s vocal style on this differs a bit to the two previous songs. It’s a bit cleaner, but still holds the intense emotional weight all the same. It’s probably the first song on the album that struck me as a bit weaker than the others, but with such strong songs surrounding it, “Pillow Talk” has its own hold on you all the same.
“Kaleidoscopes” goes back to the grittier vocals and it’s a definitive pop-punk song from beginning to end. With catchy lyrics and a flawless state of the band behind Joyce, it’s hard not to fall in love with this one. With the clear change up to “Just As I Am” Major League really shows the beginning of their diversity throughout this part of the album. It acts as a medium between the songs surrounding it, and Joyce’s voice is much softer and more calm. However, the upbeat yet relaxed music in the background keeps it the smoothest flowing song on the album.
“Montreal” is, hopefully, going to become an anthem for anyone who has been through depression. It honestly hit home so much for me, that I had a hard time objectively listening. It is truly a beautiful and honest song that is a perfect break in the album with the pairing of the acoustic guitar, Joyce’s voice, and the honest lyrics that you can’t escape. It is my personal favorite on the album.
“Little Eyes” is a heartbreaker, but it’s a perfect transition from “Montreal” into the rest of the album with the lighter guitar parts and easy going vocals throughout the beginning before getting into the heavier side of the song that sets up the remainder of the album. “Little Eyes” is able to take us back to that rough punk sound that Major League does so well, and leads us right into “Recovery.” This song has more of a change-up thrown in. It’s a bit mellower throughout the verses, but the chorus keeps that passion and raw vocals that make the album so great. The contrasts between the mellow and rough parts of the song probably make it the most diverse and different on the album.
“Devil’s Advocate” doesn’t disappoint either. It’s a high-energy song that propels the album into its final two songs. The lyrics are extremely addictive, and the high-strung guitar and drum parts match Joyce’s voice effortlessly. It does flow really well into “Bruiser.” Although, this one is a bit more of a generic pop-punk song. Lyrically, it’s fantastic, the words themselves are strong and easy to remember. The music is catchy, but it stands out the least to me on the album. It’s a great song, a good transition between the two around it, and it fits the album well, but it’s not a song I’d pick to stand alone.
“Rittenhouse” is another extremely personal song from Joyce, and it’s hard not to get addicted to it. With a bit of a relaxed feel to the beginning of the final song, it’s easily one of the best on the album. When the full band comes in, you really get a sense of the powerful emotions behind the song, and it wraps up the album beautifully.
The album itself is a great glance into the future to Major League with a sincere respect to their past. Pick up a copy of There’s Nothing Wrong With Me today here! Also, be sure to check them out on tour with Mayday Parade this fall, and Silverstein early 2015!
By: Shelby Chargin


text:
Three fishermen are feared dead after their boat capsized in the Indian Ocean in Lamu County.
A total of five fishermen had gone for their daily fishing activities in the Indian Ocean on Saturday evening.
According to Lamu County Coast Guard, following strong winds and tides that hit their boat at around midnight, the fishermen sensed danger, and two of them were forced to swim for about 3 hours to the Mpeketoni seashore to seek help.
“Following the distress call we joined the two frightened fishermen to where their boat with the other three colleagues was stuck, however, on reaching the destination neither the boat nor the fishermen were there,” said an official from the Coast Guard, Lamu County.
The five who come from the Ngomeni area in Malindi, Kilifi County had camped at Mpeketoni in Lamu where they have been indulging in fishing activities for months.
Lamu county Indian Ocean waters have in the past weeks experienced strong tides, with authorities warning all operators to be very vigilant.
Both fishermen and boat operators ferrying locals to various islands in the county have been cautioned against reckless operations.
Recently, Lamu County Kenya Maritime Authority (KMA) official Alexander Munga said the Indian Ocean, Lamu County was experiencing high tides, urging all operators to carry on with their activities, cautiously.
“We should not ignore any alert from the Metrological department since the current situation in the Indian Ocean is truly unpredictable,” said Mr. Munga.
The rescue operations involving the Lamu county government disaster management team, The Kenya Coast Guard, the Kenya Navy, the Kenya Red Cross Society, the Lamu County branch, and local fishermen are still underway.

domain: news


text:
‘We’ve reclaimed our voices. We’re optimistic about using them to continue this conversation': statement
Two women who signed non-disclosure agreements with the University of Prince Edward Island a decade ago have been permanently released from the threat of lawsuit for speaking out about their experiences, with the university's board of governors issuing an unequivocal apology.
Wendy Carroll and Erin Casey, who have asked that their names now be made public, filed complaints of sexual harassment in 2012 against the university's former president, Alaa Abd-El-Aziz. Eventually they took those complaints to the P.E.I. Human Rights Commission before being offered settlements and signing non-disclosure agreements (NDAs) with the university in 2013.
"After 11 years of silence, we feel heard," Carroll and Casey said in a written statement Thursday following the news that UPEI had permanently released them from the terms of their NDAs.
"We acknowledge UPEI's apology for the personal, professional, and reputational harms we've suffered in the past decade."
In early 2022, the university hired Rubin Thomlinson LLP — the same Toronto-based law firm that conducted a workplace investigation at CBC News after the firing of radio host Jian Ghomeshi — to conduct a review of harassment, discrimination and fair treatment processes at UPEI.
That was shortly after a fresh allegation of misconduct was brought forward against the former president in late 2021. Abd-El-Aziz announced his retirement that December, and the university says it no longer has any affiliation with him.
The two women were offered temporary releases from their NDAs to take part in the Rubin Thomlinson review, but Abd-El-Aziz was also a signatory to those agreements. In June, UPEI told CBC News that Abd-El-Aziz had not agreed to release the women from the requirement for confidentiality.
Casey and Carroll asked the university to offer indemnification to provide legal protection if Abd-El-Aziz chose to sue them. However, UPEI would not offer to indemnify the women on a permanent basis, only long enough to allow them to participate in the Rubin Thomlinson review.
As a result, neither Casey or Carroll participated in the review.
CBC News has repeatedly tried to reach Abd-El-Aziz for comment on the report and its aftermath, without success.
Later Thursday morning, the UPEI Faculty Association reiterated its request for an unredacted copy of the report, and requested an independent third-party review of redactions that were made before its release in June. The association suggested the cost be shared by the board of governors and the campus unions.
Report on 3rd-party review of UPEI allegations (PDF KB)
Report on 3rd-party review of UPEI allegations (Text KB)CBC is not responsible for 3rd party content
'We've reclaimed our voices'
In Thursday's statement, the women say they've finally been able to reclaim their voices thanks to the permanent release.
"Our goal has always been, and remains, to ensure that what happened to us never happens to anyone else," the statement reads.
"We also want to affirm our leadership roles on the issue of non-disclosure agreements (NDAs) and the harms they can cause in cases of harassment and discrimination.
"We've reclaimed our voices. We're optimistic about using them to continue this conversation."
Casey was a graduate student in UPEI's Faculty of Education and a full-time staff person in the office of UPEI's president at the time she and Carroll brought forward their complaints. Carroll was a professor with UPEI's School of Business. Both women moved away from P.E.I. after filing their complaints.
'A process of reconciliation'
Shannon MacDonald was appointed as UPEI Board of Governors chair earlier this summer after previous chair Pat Sinnott resigned. In Thursday's statement, she said the board is committed to following "every single recommendation" contained in the Rubin Thomlinson report.
"One of the ways that the university has accepted accountability since the release of the Rubin Thomlinson report has been by making amends to those who have been harmed," the statement reads.
"The university will not prevent them [Casey and Carroll] from having their voices heard and from sharing their stories, should they so choose."
MacDonald thanked the women for agreeing to meet with her and sharing their experiences over the last decade.
"Together, we have begun a process of reconciliation. We hope that this is a restorative path for them, and for the university community, as we work towards healing."
Earning back trust
MacDonald also offered an apology for the university's handling of the complaints.
"We are truly sorry that the university and the board failed to live up to our values when it comes to harassment and equality," reads the statement.
"We apologize for our past failures to meet the expectations of the UPEI community. We must do better, and we will. We will continue to work hard to create a safe, respectful, and positive environment for all members of the UPEI community."
MacDonald pointed to changes in the board's leadership, as well as the creation of a new vice-president responsible for people and culture at the university, as first steps.
We have much trust to earn, and we are at the beginning of that process. We want to take the time and do this right.
— Shannon MacDonald, chair of UPEI board of directors
She added that an action plan based on the report's recommendations is being developed.
"We have much trust to earn, and we are at the beginning of that process. We want to take the time and do this right," MacDonald said in the statement.
"We know we can learn and improve through this restorative process, and we believe that they [Casey and Carroll], along with others, can provide guidance so that something like this cannot easily, if ever, happen again to anyone at UPEI."
ABOUT THE AUTHOR
Digital senior producer, CBC P.E.I.
Devon Goodsell is a producer with CBC Prince Edward Island. She previously worked as a producer at the national CBCNews.ca desk in Toronto, and as a reporter at CBC Vancouver. The CBC P.E.I. team most recently took home two east region Radio Television Digital News Association Canada awards, including overall excellence in digital.
Credit belongs to : www.cbc.ca


text:
Varicella-zoster virus (VZV) can be fatal or induce severe complications in children with acute lymphoblastic leukemia (ALL). Untreated VZV infection has a mortality rate of 7%–10% in this group of patients.1 In about 30% of children who do not receive antiviral therapy, there is dissemination to lungs, liver and heart.2 The routine implementation of prompt prophylaxis with immunoglobulins and acyclovir, in particular at exposure to VZV, has significantly reduced the incidence of severe complications of VZV infection.3–5 However, in countries where the VZV vaccine is not part of the national vaccination program, the risk of VZV exposure still compromise the daily lives of many children with ALL during their 2–3 years of antileukemic treatment. Their families have to be alert to potential infection at all times, and are not always aware of an exposure, because the classic varicella presentation with a vesiculopapular rash is not always present.6,7 To minimize the risk of VZV exposure, Danish preschool children who have not had VZV are isolated from normal day care during their cancer treatment. Until recently it has been internationally approved practice to vaccinate children with ALL against VZV, and several studies have shown that the vaccine can be used safely and effectively in these patients.8–11 However, a recent study argued that the risks associated with vaccination may be greater than those associated with acquisition of the infection itself.12 The main concerns are of one reported case of death related to VZV vaccination and the possible increased risk of relapse of ALL due to discontinuation of maintenance therapy before, during and after vaccination.13 In most studies, maintenance therapy has been interrupted for 14 days around the time of the first vaccination to ensure a proper immune response to the vaccine. Only a few and relatively small studies describe vaccination of children with ALL without interruption of chemotherapy. In these studies, the children achieved a sufficient immune response toward the vaccine.14–16 Since 1997, VZV-seronegative children have been vaccinated against VZV without concomitant interruption of maintenance therapy at the Copenhagen University Hospital, Rigshospitalet, Denmark. In this retrospective analysis, we describe the mortality and morbidity related to VZV vaccination and infection among seronegative children with ALL.
MATERIALS AND METHODS
The analysis included all 223 children diagnosed with ALL from 1996 to 2011 at Copenhagen University Hospital. Of these, 78 (35%) were VZV seronegative at the time of diagnosis. Five children were excluded: 3 had moved to another part of the country and their files were not retrievable and 2 died within 2 weeks of diagnosis. Thus, altogether 21 VZV-seronegative girls and 52 boys, aged 0–16 years at the time of diagnosis (median: 3, range 11/12–16 5/12) were included in the analysis. Thirty patients had standard risk ALL, 29 had intermediate risk, 12 had high risk, 1 had infant ALL and 1 was diagnosed in Italy. Risk grouping criteria have been reported previously.17 The children were treated according to the ALL protocols 1992 (n = 25), 2000 (n = 28), 2008 (n = 18) and interfant 99 of the Nordic Society of Paediatric Haematology and Oncology and in 1 case mainly by the Italian protocol Italian Association of Pediatric Hematology and Oncology.18,19 All patients received maintenance therapy with 6-mercaptopurine (75 mg/m2/day) and methotrexate (MTX; 20 mg/m2/week) targeted to a white blood cell count of 1.5–3.5 x 109/L (ALL92/ALL2000) or 1.5–3.0 × 109/L (ALL2008). Furthermore, depending on the protocol, patients received high-dose MTX (HDM; 5 g/m2 with leukovorin rescue and intrathecal MTX), vincristin (2.0 mg/m2 × 1) with dexamethasone, or prednisolone for 5–7 days at alternating intervals. Seven children experienced relapse of ALL at a median time of 2 years and 9 months from diagnosis. Four of these children were immunized within a median time of 19 months (range: 17–45 months) before the time of recurrence, and only 1 of these had maintenance therapy discontinued for 3 days related to a VZV vaccine-induced rash.
The children fulfilled the following criteria at the time of VZV vaccination: (1) seronegative at the time of diagnosis, (2) in complete remission, (3) age ≥ 1.0 year, (4) lymphocyte count ≥ 0.6 × 109/L at time of vaccination (although ≥0.8 × 109/L during the first 6 months of 1997) and (5) receiving MTX/6-mercaptopurine maintenance therapy. The children were vaccinated with the live attenuated vaccine Varilrix (GSK) without discontinuation of chemotherapy before, during or after the vaccination (except from the routine criteria for pausing due to, eg, fever or cytopenia). If the children were seronegative after the first vaccination, they were vaccinated once more. In 2007, international guidelines changed and all children were vaccinated twice.20 However, the children who developed a rash after the first vaccination did not receive a second vaccination irrespective of the presence of VZV antibodies. From 1997 to 2011, the vaccinated children were only treated with acyclovir, if they developed a vaccine-induced rash after vaccination. To make sure they did not transmit VZV to seronegative children, they were isolated from the ward from day 7 to 40 after vaccination. In contrast, those children vaccinated between 2011 and 2013 (n = 11) received acyclovir prophylaxis (valacyclovir 20 mg/kg/dose twice a day) from day 7 to 40 after the time of vaccination to avoid this isolation. Day 7 was chosen to ensure that the primary viremia was completed.
The following data were retrieved from hospital files: dates of vaccine-induced rash, late chickenpox, reactivation of VZV and herpes zoster; lymphocyte count at the day of vaccination; number of days of acyclovir prophylaxis and treatment; number of days of interruption of maintenance therapy; number of days spent isolated from the ward; length in days of hospital admissions and administration of chemotherapy around the time of vaccination (HDM from 3 weeks before to 2 weeks after vaccination and dexamethasone from 2 weeks before until 40 days after vaccination). The number of chickenpox lesions was registered and divided into 3 groups: a small number (0–49), a moderate number (50–99) and multiple (>100).
The laboratory testing for the characterization of the varicella type as either vaccine or wild-type has not been consistent during the analysis period. Therefore, we defined chickenpox as vaccine-induced VZV if developed within 60 days of vaccination, whereas reactivations were defined as repeat incidences of rash within 60 days of vaccination. Chickenpox developed more than 60 days after vaccination was defined as late chickenpox. Day 60 was chosen to ensure that the rash was not vaccine induced because previous studies have shown that immunocompromised children are at risk of developing vaccine-induced rash for longer than healthy children.15 From 1997 to 2006, the parents of the vaccinated children were given a questionnaire at the day of vaccination. They were asked to register incidences of rash, fever, medical contacts, local reactions and other adverse effects associated with the vaccination. As part of this analysis, a questionnaire was sent to all parents, unless their child had died (n = 69), and 53 received a follow-up call to clarify their response. The children’s VZV titer was measured in 38 (84%) of the 45 immunized children after the first vaccination. The remaining 7 children all developed a vaccine-induced rash and were considered seropositive. Titers were not measured routinely after the second vaccination, and all children were regarded as being VZV protected irrespective of their antibody response. A follow-up titer was measured in both immunized (33/45) and nonimmunized children (13/29) during 2012 and 2013 to analyze their long-term seroconversion. There was a median follow-up time of 4 years and 6 months (2/12–15 7/12) from time of vaccination, and a median follow-up time of 7 years and 9 months (8/12–16 2/12) from time of late chickenpox. Seven children received a bone marrow transplant within a median time of 3 years and 3 months (range: 7/12–9 9/12 years) from diagnosis and were excluded from the follow-up blood tests. All vaccinated children were kept in isolation until their vaccine-induced rash had cleared or until they had had 2 vaccinations.
Frequencies were compared using Fisher exact test. Quantitative data are presented with medians and ranges. The association between explanatory variables (HDM, dexamethasone, acyclovir and lymphocyte count) and the risk of rash, as well as of getting late VZV, was assessed using survival analysis: that is, for each patient time-to-rash was determined, censoring patients at 60 days after vaccination (corresponding to the patients classified as no longer being at risk of developing vaccine-induced rash). Those patients who did not appear to develop a rash after the first vaccine received a second, that is, multiple survival times occur. The data were analyzed using an extension of the Cox regression model to multiple events and time-dependent explanatory variables. The model was stratified on vaccination (first or second) and the 2 baseline hazards were assumed identical (considering the time point of vaccination as time 0 for both vaccinations) using a Prentice-Williams-Peterson gap time model.21 Treatments given after vaccination (acyclovir and/or dexamethasone) were treated as time-dependent explanatory variables. The effects of the explanatory variables were further assumed equal for both vaccinations. Univariable and multivariable analyses were performed and, as the dataset is relatively small, a backward elimination procedure was applied to identify the most important explanatory variables. Analysis of time to late VZV was performed using years since diagnosis as underlying timescale and delayed entry at the time of first vaccination. Survival estimates were calculated by the Kaplan–Meier method and univariable Cox regression analyses with rash (yes/no), number of vaccinations (1 or 2) and acyclovir treatment (yes/no) as time-dependent explanatory variables were performed. The statistical analyses were performed using SAS version 9.4. P values less than 0.05 were considered significant.
Altogether 45 children were vaccinated. They received their first vaccination within a median time of 37 weeks (range: 3–102 weeks) from the beginning of maintenance therapy. Fifteen of these (33%) were vaccinated twice with a median time of 11 weeks (range: 5–22 weeks) between the 2 vaccinations. No child experienced serious adverse events such as local inflammation, VZV pneumonitis, visceral dissemination, secondary bacterial infection or death due to VZV vaccination.
Nine children, including 6 children still on maintenance therapy, developed late chickenpox despite their vaccination within a median time of 49 weeks (range: 11–86 weeks) from vaccination (Table 1). Thus, 78% (65; 92) of all vaccinated children were regarded as being protected by the vaccine. In the group vaccinated before 2011 that did not receive acyclovir prophylaxis, 86% were protected (73; 100). We found an association between acyclovir prophylaxis after vaccination and the risk of developing late chickenpox [hazard ratio (HR) 5.40 (1.43, 20.41), P = 0.01]. Furthermore, our data indicated that a vaccine-induced rash reduced the risk of late chickenpox [HR 0.08, (0.01, 0.66), P = 0.02; Table 1].
Twenty-five of all vaccinated children (56%) developed a vaccine-induced rash within a median time of 27 days (16–43), and of these, the majority (80%) developed fever at a median duration of 2 days (range: 1–5 days). Among the children that did not receive acyclovir prophylaxis, 65% (22/34) developed a rash (Table 2). Sixteen (64%) of all children with a rash had a small number of lesions, 5 (20%) had a moderate number of lesions and 4 (16%) had multiple lesions. Acyclovir prophylaxis was associated with a reduced risk of rash (P = 0.01; Table 2).
Four children experienced reactivation of their vaccine-induced rash at day 49–57 after vaccination of whom 2 cases were verified as vaccine type. Four children developed herpes zoster at day 64, 70, 78 and 442 from vaccination.
Children treated with dexamethasone within 15 days before and up to 40 days after vaccination tended to have a higher risk of rash (P = 0.01). We found no association between HDM 3 weeks before vaccination and a vaccine-induced rash (P = 0.05; Table 2). The vaccinated children with a rash had a median lymphocyte count of 0.96 × 109/L (range: 0.5–1.4 × 109/L) at the time of first vaccination and 1.13 × 109/L (range: 1.06–1.19 × 109/L) at the time of second vaccination. Three children had a lymphocyte count lower than 0.6 × 109/L, but were not excluded from the analysis (Table 3). A high lymphocyte count was associated with a reduced risk of vaccine-induced rash in the unadjusted analysis, but the association disappeared when adjusted for either dexamethasone (P = 0.10) or acyclovir (P = 0.11). No child had their maintenance therapy discontinued because of vaccination, but 6 children (13%) had an interruption of chemotherapy for other reasons around the time of vaccination, with a median duration of 6.5 days (range: 1–15 days). Fifteen children (33%) experienced discontinuation of maintenance therapy because of vaccine-induced rash for a median time of 4 days (range: 1–9 days).
More children with a rash were found to be seropositive after the first vaccination compared with children with no rash [14/16 (88%) vs. 6/22 (27%), P = 0.01; Table 3]. Additionally, more children not receiving acyclovir prophylaxis seroconverted after the first vaccination, compared with children receiving prophylaxis [8/28 (71%) vs. 0/10 (0%), P = 0.01]. Long-term seroconversion was found in 52% (17/33) of the children.
A total of 28 children were not vaccinated because of low lymphocyte count, poor general condition or their treating physician being unaware of the possibility of vaccination. Sixteen of these (57%) were exposed to VZV during maintenance therapy with a median of 2 exposures (range: 1–6), regardless of attempt to secure persistent isolation from exposed nonimmune healthy children. Despite the strict isolation regimen, 4 children developed clinically verified chickenpox during maintenance therapy and another 15 children developed chickenpox after completion of maintenance therapy. None of the children died of late chickenpox.
During a period of 15 years, 45 children with ALL have been vaccinated against VZV without concomitant interruption of chemotherapy. Despite most children being vaccinated early in maintenance therapy, rather than 3 months after cessation of maintenance therapy or a year from the time of remission as suggested in some guidelines,22,23 none of these children died because of VZV vaccination, and no child developed serious complications such as pneumonitis, visceral dissemination or secondary bacterial infection. Sixty-five percent of children not receiving acyclovir prophylaxis during vaccination developed a vaccine-induced rash, which is higher than previously reported in studies with suspension of maintenance therapy.8,24 The majority experienced only a mild rash and were all treated with acyclovir. There may be 2 reasons for the high number of vaccine-induced rashes in this cohort. Firstly, the children had a low lymphocyte count at the time of vaccination, because maintenance therapy was not discontinued, and our results indicate that a higher lymphocyte count might be protective against a vaccine-induced rash. We speculate that the low lymphocyte count gives the live attenuated vaccine a better opportunity to cause skin manifestations before being controlled by the immune system. Secondly, a high proportion of our cohort received dexamethasone around the time of vaccination, which was associated with vaccine-induced rash. Steroid treatment is a known risk factor for developing a vaccine-induced rash.25,26 Therefore, the timing of vaccination in relation to dexamethasone treatment is of great importance. In a recent study by Caniza et al,12 the concern surrounding VZV vaccine is centered on the death of a child related to the vaccine, as well as the interruption of chemotherapy that most ALL study groups advocate around the time of vaccination, which potentially increases the risk of recurrence of ALL. Although we did not completely avoid withholding chemotherapy, the length of time was considerably less. In previous studies, the VZV vaccine has been shown to be effective in children with ALL by protecting 85% of them against developing clinically verified chickenpox upon exposure and close to 100% protection against severe chickenpox.8 We found similar protection in our children not receiving acyclovir prophylaxis, with 86% experiencing long-term protection and 100% avoiding severe varicella. Those children who developed a vaccine-induced rash seemed to have better protection from the vaccine in terms of lower incidence of late chickenpox, which is in agreement with findings in other studies.9 It indicates that children developing clinical signs of chickenpox amount a better immune response. Until 2011, all children were isolated in their ward room if they needed admittance to the pediatric oncology department during the vaccination period because of the risk of exposing other immunosuppressed seronegative children. Acyclovir prophylaxis was introduced in 2011 to avoid this isolation. However, this prophylaxis seems to have resulted in significantly fewer children developing a vaccine-induced rash and hence being protected against late chickenpox. The negative effect of acyclovir prophylaxis on vaccine efficacy has not previously been reported.
Only 52% of all vaccinated children had long-term VZV seroconversion. However, only 9 children developed late chickenpox despite the high exposure risk to VZV. This indicates that cell-mediated immunity plays an important role regarding immunity in VZV, as described in other studies.27–29 One of the main concerns for parents of seronegative children with ALL in Denmark is the extensive isolation from an active social life, because the varicella vaccine is not part of the national vaccination program. It is impossible to avoid exposure to VZV completely, because there is a long incubation period and often the parents are not aware that their child has been exposed. In this cohort, 57% of the nonimmunized children were exposed to VZV, in spite of their isolation regimen, and 4 actually developed chickenpox during maintenance therapy. Accordingly, the majority of these nonimmunized children could have benefitted from VZV vaccination and lived a close to normal social life during maintenance therapy.
The weakness of our analysis is its relatively small size and retrospective design. However, it is still larger than previous reports of VZV vaccination without discontinuation of maintenance therapy.14–16
This analysis indicates that VZV vaccination without interruption of chemotherapy is feasible and justified in seronegative children with ALL in countries where VZV vaccination is not part of the national vaccination program. However, it is of great importance that the vaccination is administered by specialists and all adverse effects registered, because the vaccine is used off label.
Acyclovir should not be used as prophylaxis to avoid vaccine-induced rash, because it increases the risk of vaccine failure, although acyclovir treatment should be initiated as soon as the child shows signs of a rash.
The authors thank the staff of the Department of Paediatric Haematology and Oncology at Copenhagen University Hospital.
1. Feldman S, Hughes WT, Daniel CB. Varicella in children with cancer: seventy-seven cases. Pediatrics
2. Feldman S, Lott L. Varicella in children with cancer: impact of antiviral therapy and prophylaxis. Pediatrics
3. Shinjoh M, Takahashi T. Varicella zoster exposure on paediatric wards between 2000 and 2007: safe and effective post-exposure prophylaxis with oral aciclovir. J Hosp Infect. 2009;72(2):163–168.
4. Kumagai T, Kamada M, Igarashi C, et al. Varicella-zoster virus-specific cellular immunity in subjects given acyclovir after household chickenpox exposure. J Infect Dis. 1999;180:834–837.
5. Zaia JA, Levin MJ, Preblud SR, et al. Evaluation of varicella-zoster immune globulin: protection of immunosuppressed children after household exposure to varicella. J Infect Dis. 1983;147:737–743.
6. Rowland P, Wald ER, Mirro JR Jr., et al. Progressive varicella presenting with pain and minimal skin involvement in children with acute lymphoblastic leukemia
. J Clin Oncol. 1995;13:1697–1703.
7. Matsuzaki A, Suminoe A, Koga Y, et al. Fatal visceral varicella-zoster virus infection without skin involvement in a child with acute lymphoblastic leukemia
. Pediatr Hematol Oncol. 2008;25:237–242.
8. LaRussa P, Steinberg S, Gershon AA. Varicella vaccine for immunocompromised children: results of collaborative studies in the United States and Canada. J Infect Dis. 1996;174(suppl 3):S320–S323.
9. Gershon AA, Steinberg SP, Gelb L. Live attenuated varicella vaccine use in immunocompromised children and adults. Pediatrics
. 1986;78(4, pt 2):757–762.
10. Brunell PA, Shehab Z, Geiser C, et al. Administration of live varicella vaccine to children with leukaemia. Lancet. 1982;2:1069–1073.
11. Takahashi M, Kamiya H, Baba K, et al. Clinical experience with Oka live varicella vaccine in Japan. Postgrad Med J. 1985;61(suppl 4):61–67.
12. Caniza MA, Hunger SP, Schrauder A, et al; Members of International Study Group of Childhood ALL (“Ponte di Legno Working Group”). The controversy of varicella vaccination
in children with acute lymphoblastic leukemia
. Pediatr Blood Cancer. 2012;58:12–16.
13. Schrauder A, Henke-Gendo C, Seidemann K, et al. Varicella vaccination
in a child with acute lymphoblastic leukaemia. Lancet. 2007;369:1232.
14. Ha K, Baba K, Ikeda T, et al. Application of live varicella vaccine to children with acute leukemia or other malignancies without suspension of anticancer therapy. Pediatrics
15. Arbeter AM, Granowetter L, Starr SE, et al. Immunization of children with acute lymphoblastic leukemia
with live attenuated varicella vaccine without complete suspension of chemotherapy. Pediatrics
16. Sato Y, Miyano T, Kawauchi K, et al. Use of live varicella vaccine in children with acute leukemia and malignant lymphoma. Biken J. 1984;27:111–113.
17. Schmiegelow K, Forestier E, Hellebostad M, et al; Nordic Society of Paediatric Haematology and Oncology. Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia
. Leukemia. 2010;24:345–354.
18. Frandsen TL, Heyman M, Abrahamsson J, et al. Complying with the European Clinical Trials directive while surviving the administrative pressure – an alternative approach to toxicity registration in a cancer trial. Eur J Cancer. 2014;50:251–259.
19. Toft N, Birgens H, Abrahamsson J, et al. Risk group assignment differs for children and adults 1-45 yr with acute lymphoblastic leukemia
treated by the NOPHO ALL-2008 protocol. Eur J Haematol. 2013;90:404–412.
20. Committee on Infectious Diseases. Prevention of varicella: recommendations for use of varicella vaccines in children, including a recommendation for a routine 2-dose varicella immunization schedule. Pediatrics
21. Prentice RL, Williams BJ, Peterson AV. On the regression analysis of multivariate failure time data. Biometrika. 1981;68:373–379.
24. Gershon AA, Steinberg SP. Persistence of immunity to varicella in children with leukemia immunized with live attenuated varicella vaccine. N Engl J Med. 1989;320:892–897.
25. Hill G, Chauvenet AR, Lovato J, et al. Recent steroid therapy increases severity of varicella infections in children with acute lymphoblastic leukemia
26. Lydick E, Kuter BJ, Zajac BA, et al. Association of steroid therapy with vaccine-associated rashes in children with acute lymphocytic leukaemia who received Oka/Merck varicella vaccine. NIAID Varicella Vaccine Collaborative Study Group. Vaccine. 1989;7:549–553.
27. Gershon AA, Steinberg SP. Cellular and humoral immune responses to varicella-zoster virus in immunocompromised patients during and after varicella-zoster infections. Infect Immun. 1979;25:170–174.
28. Arvin AM, Koropchak CM, Williams BR, et al. Early immune response in healthy and immunocompromised subjects with primary varicella-zoster virus infection. J Infect Dis. 1986;154:422–429.
29. Weinberg A, Levin MJ. VZV T cell-mediated immunity. Curr Top Microbiol Immunol. 2010;342:341–357.
Keywords:Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
varicella zoster virus; vaccination; pediatrics; acute lymphoblastic leukemia; childhood leukemia

domain: medical


Facing the Australian in Saturday's title decider will be a favourite of the Milan crowd - 18-year-old wild card Sinner, who rallied from a set down to defeat Kecmanovic 2-4 4-1 4-2 4-2. "I didn't feel so well in the beginning and he was playing very good, very aggressive". He and Sinner have never played, but De Minaur has been impressed by the Italian's run.
"It's unbelievable", Sinner said. Sinner, after starting the year at No. 551, has climbed 456 spots in the ATP Rankings this season and beat Nitto ATP Finals alternate Gael Monfils last month en route to the semi-finals of the European Open, an ATP 250.
However, De Minaur ultimately had too much firepower and, after a victor teed up match point, a stray shot into the net from Tiafoe handed the 20-year-old a second successive final appearance. He sealed the victory on his first match point when his American opponent hit a forehand into the net. "He has enormous firepower and he's never going to give up", said De Minaur, who has lost just one of his nine matches at the Next Gen Finals. I see there being a big skill difference and that should result in an easy win for Alex de Minaur. It's easy because you know that no matter what happens on the court, you're still going to be the best of friends.
Alex de Minaur is the top seed in Milan, the highest-ranked player in the field (No. 18) and the 2018 Next Gen ATP Finals runner-up (l.to Tsitsipas). "I don't see it as I'm the favourite; I see it as it's just another tennis match", he said. It's a tennis match, and you're playing your opponent. This is expected to be a tough match for Jannik Sinner as he is playing against the top seed. "It's about whoever plays better on the day".
Rising Serbian star Miomir Kecmanovic has nothing but good to say of the Next Gen ATP Finals, which are taking place at the Allianz Cloud in Milan.


text:
Khalfani returns to Richmond in advocacy role
Jeremy M. Lazarus | 12/16/2021, 6 p.m.
The former executive director of the Virginia State Conference of the NAACP is the newest member of the lobbying team of the Richmond- based Virginia Interfaith Center for Public Policy, a coalition of 750 faith groups that advocates for economic, racial and social justice.
King Salim Khalfani, 62, who has spent four decades speaking out for civil and human rights in Virginia, has been tapped to be the center’s organizer on issues related to criminal justice reform, according to Kim Bobo, executive director of the interfaith policy group.
Abolition of solitary confinement in Virginia prisons will be one of the key issues Mr. Khalfani will be focusing on in the upcoming session, Ms. Bobo said. He already is pulling
together religious leaders for a news conference in January to highlight the issue at the start of the General Assembly.
“VICPP is thrilled to have someone with the wisdom, experience and stature that Mr. Khalfani brings to the team. He will help guide our criminal justice reform work by deepening our community connection,” Ms. Bobo said.
Mr. Khalfani expressed excitement about his new role.
“I have worked with VICPP much of the last two decades at the General Assembly on legislative issues, so I’m aware of the organization’s legislative victories and was attracted to that. I look forward to achieving more victories with them at the legislature.”
Mr. Khalfani replaces the Rev. Jamar Boyd II, who left to become senior manager for organizational impact for the Chicago-based Samuel Dewitt Proctor Conference Inc. that seeks to organize the faith community nationally to collaborate with civic, corporate and philanthropic leaders on social justice issues.
“The struggle has been my life,” said Mr. Khalfani, a Cleveland, Ohio, native, who is perhaps best known across the state for the 16 years he served as the outspoken leader and chief lobbyist for the Virginia State Conference of the NAACP.
He most recently served as policy and advocacy director for Nexus Services Inc. of Harrisonburg and operated a consulting firm to assist people seeking clemency and pardons.
A 1983 history and political science graduate of Virginia Union University, Mr. Khalfani began his career with the Richmond Peace Education Center and was among the early staff advocates for Virginians for Alternatives to the Death Penalty.
Mr. Khalfani joined the state NAACP in 1990 as director of branch and field activities and moved up to executive director in 1998.
Since leaving that post, he has been a Virginia Education Association UniServe director in Portsmouth and Hampton Roads and he founded and led Americans Resist- ing Minority and Ethnic Discrimination with Nexus Services.


text:
During my stay through the Persian Gulf there is something that really surprised me, and it is the mistreatment to the Asian immigrants, who are fifteen million people, what according someone explained me, it means more than half of the population of the area.
I met Raifed during my stay in Bahrain, and to talk with him was so interested, because he is one of the 5 millions Iraqis refugees, who told me about the situation in his country.
During my journey in the south of Italy, I knew Francesco, a Political Sciences student who carried out a work about the mafia in the high school. During my journey in the south of Italy, I knew Francesco, a Political Sciences student who carried out a work about the mafia in the high school. According to him the mafia is a historical phenomenon that goes back to the middle of the XIX century
More than 3000 years ago, the Queen of Ethiopia “Sheba” travelled to Israel to find Salomon. She had a child with him who was born on her return and was called Menelik, the first emperor of a new Salomonic Dinasty. Since then, the lineage of Menelik was kept in Ethiopia as in any other place of the world, till in 1930, Tafari, the new emperor, was crowned as the 225th descendent.

domain: geography


text:
I’ve always found Lamy pens to be really pleasurable to use, but I must admit that the design, the material and construction of my Lamy pens (Safari) don’t impress me much. I like TWSBI’s hard plastic but I really, really don’t like Lamy Safari’s lighter plastic. Safari is popular with a lot of people, though. It’s light, easy to maintain and it’s a great entry-level fountain pen.
The nibs of Lamy pens in general, however, are always really reliable and write very well. I’ve seen the Studio and 2000 in National Bookstore and I’ve always been curious about them since they look nothing like Safaris, but I never tried holding them or looking closer. I like the 2000’s design, but I’m not crazy about the hooded nib. I prefer open nibs.
So, my husband bought me a Lamy Studio a few days ago as a birthday gift and it was delivered to our house this morning. I’m pleased to say that it was actually love at first touch.
The pen feels much lighter than it looks. It’s not uncomfortably heavy to hold *cough*sheaffer300*cough* and I love its texture. The body is made of brushed stainless steel. I think it’s not a texture that a lot of people will like on their pen, but I personally love it. It makes the pen easy to hold and interesting to look at. Everything about the design of this pen speaks of excellent German product engineering. It’s utilitarian, clean, minimalist, and no-frills. It seems very harmonious and seamless, for the most part.
There are other Lamy Studios that come in different colors, but the section of those pens are made of a glossy metal finish. This stainless steel Studio has a section that is made of a hard rubberized finish. Again, a design choice that perhaps not many will like, but I do love it.
My reason for that is because of practicality. Unlike the glossy metal finish, this one’s easy to hold whether my hand is dry or damp. Glossy sections tend to become slippery when the temperature is cold and my hand becomes too dry. This one is pleasant to hold and helps me write for a long period of time without feeling discomfort from holding the pen. It sits securely between my fingers while writing and provides a comfortable grip. Yes, I did try writing with it for a long period of time (most of my day, actually). The hard, rubberized finish doesn’t attract too much fingerprints, doesn’t get grimy, and is easily wiped clean of ink when refilling.
Its clip looks like a duck bill or a small propeller. Again, this design choice may not be pleasing for all fountain pen enthusiasts because it’s quite unconventional-looking, but I like how it looks. I don’t use the clip to fasten the pen’s cap on my shirt or even in my pen wrap. I’m a little OCD with the clips so I just tuck it inside the pen wrap without slipping the fabric under the clip. From an aesthetic point of view, I like the unconventional design. It makes the otherwise very industrial-looking pen look more interesting.
As mentioned earlier, the pen is lighter than it looks. I believe it’s about 30g, cap and body. It balances really well. It’s neither too heavy on the top or the bottom. It’s pleasant to use posted or unposted. The cap snaps on and off and also posts with a snap. Below is a picture of the cap as it’s posted at the end of the barrel.
This is actually the only thing about the pen that I’m not entirely sold on. Everything about the design is seamless and flows fluidly together. Why they made the cap to have this tiny little wiggle room when posted is beyond me. It would have looked a lot prettier if it was made to friction fit onto the end of the barrel.
On the other hand, it does make sure that the cap doesn’t leave a scratch while posted. It’s one of my two pens that post with a click and does not friction fit with the barrel (the other one is the Waterman Expert II). It’s just a little niggling for me, design-wise. I don’t like the tiny gap but yeah, I can live with it. No biggie.
Lamy Studio stainless steel doesn’t usually come with a gold nib, but the beauty about Lamy pens is that you can always use other standard Lamy nibs. It’s pretty easy to switch. As predicted, the pen is a wet, reliable writer. It lays down a consistent, wet line that gorgeously shows off ink shading on fountain pen-friendly paper (I used Rhodia in the photo above). The ink flow is generous without being too wet. I tried it on my new Muji journal (the one with the hard, black cover which has paper that’s a bit thinner than the brown one with 5% recycled paper) and it doesn’t bleed through even a bit.
I’ve used several pens with gold nibs before and, truth be told, my personal preferences is really leaning more towards the stainless steel nibs. Yes I love the springiness and the consistent lines of this beautiful gold nib, but I soon swapped it out with a regular steel medium nib later in the evening, after I used it for almost the whole day.
Here is a video of my writing sample. I initially inked it with Noodler’s Burma Road Brown, completely forgetting that I meant to ink it up with Diamine Dark Olive.
As you can see, there’s no hard starting, no skipping, no railroading. I inked it up, wiped it off and it’s ready to go!
I truly enjoyed using this pen. It gave me a great writing experience. I’ll perhaps try to acquire another one next month, probably a blue one with the glossy metal section. If you’re looking for a great mid-level fountain pen that is beautifully designed, is a reliable writer, feels great in the hand (both in size and weight) and won’t break the bank, I would highly recommend this pen.

domain: artistic


Women, especially younger women, are more likely than men to show up at the hospital with no chest pain or discomfort after having a heart attack, a new study suggests.
Those symptoms, or lack of symptoms, can result in delayed medical care and differences in treatment that might in turn help explain why women in the study were also more likely to die of their heart attacks, according to researchers.
"They might not even know they're having a heart … full story
Women who drank two large glasses of milk daily after their weight-lifting routine gained more muscle and lost more fat compared to women who drank sugar-based energy drinks, says a new study.
“Resistance training is not a typical choice of exercise for women,” says Stu Phillips, professor in kinesiology (study of human movement) at McMaster University.
“But the health benefits of resistance training are enormous: It boosts strength, bone, muscular … full story
Australian scientists claim to have discovered a gene responsible for baldness in women which may lead to an effective treatment for hair loss.
Researchers at the University of Melbourne and St Vincent’s Hospital studied the DNA of almost 500 women who had lost at least 50 percent of hair on their scalp. Aged between 18 and 65, all the women who participated in the study, suffered severe hair loss, a condition that will affect up to 55 percent … full story
Women who use common painkillers like ibuprofen and naproxen early in pregnancy may have an increased risk of miscarriage, a study published Tuesday suggests.
Researchers found that of nearly 52,000 Quebec women who had been pregnant, those who'd used a non-steroidal anti-inflammatory drug (NSAID) after conceiving were more than twice as likely to suffer a miscarriage.
The researchers looked at NSAIDs other than aspirin -- which includes such common … full story
Drinking coffee boosts women’s brainpower but addles that of men.
While sipping a cappuccino or quaffing an espresso boosts women’s performance, the same drink impairs men’s memories and slows down their decision-making.
And given that Britons alone down 70 million cups of coffee a day, the implications are significant, reports the Journal of Applied Social Psychology.
Psychologist Lindsay St. Claire, Bristol University, who led the study, said: … full story
Women whose mothers are victims of stroke are at a far higher risk of a heart attack.
Women may be more at risk of inherited forms of heart disease. In men, it tends to be triggered by lifestyle factors such as diet, drinking and smoking.
Oxford University researchers looked at more than 2,200 female patients who had suffered a stroke, heart attack or angina, the journal Circulation: Cardiovascular Genetics reports.
They found that a far higher … full story
Having a baby may make a woman more intelligent. Research shows that a woman’s grey matter – brain cells that crunch information – grows in the weeks and months after she has given birth.
And it’s the most doting mothers who experience the biggest burst of brain cells. Such changes usually only occur after intense periods of learning or a brain injury or illness.
It is thought that the hormonal changes associated with having a baby ‘supercharge’ … full story
More than three million women have received medical attention or been rushed to hospital because of their passion for killer heels.
Researchers say that a fifth of women have gone to such extreme lengths to wear trendy shoes that they have ended up twisting their ankle or tearing a tendon.
And a third have fallen flat on their face as a result of their heels, with many damaging their teeth and breaking their wrists.
The poll of 3,000 women, published … full story
Acne is an inflammatory skin disease, caused by changes in skin structures consisting of a hair follicle and its associated sebaceous gland. Acne usually appears during adolescence in its most common form known as "acne vulgaris", which means common acne. The revolutionary Acne-n-pimple cream, the natural acne treatment product on the market to help you solve the never-ending problem of acne.
Excess secretions of oil glands combine with naturally … full story
About 43% of women experience some form of sexual dysfunction. Sexual dysfunction in women is described by a lack of desire, stimulation, or orgasm. Lack of desire is considered to be the most frequent illness among women. Approximately 20% of these women report having troubles with lubrication, which can be helped by Viagra Feminine a drug that may amplify blood flow to the genitals.
Some common factors that reduce women’s sexual health include: … full story
Most Popular health
- cardiovascular disease
- conditions and diseases
- daily mail
- heart attack
- heart disease
- high blood pressure
- physical exercise
- the daily mail
- united states
- weight loss


text:
Complete tips for pet parents of canines, cats and horses. Paul Navin, DVM, founded All Pets Hospital in 1993 and has over 30 years of scientific veterinary expertise. Dr. Navin in addition to basic veterinary practice and surgery can also be a distinguished English Bulldog specialist. Working with Dr. Navin are Dr. Matthew Harres and Dr. Stephen Little who’re workers veterinarians of All Pets Hospital.
Come work with our employees and dogs on enhancing adoptability. We are going to show you techniques to help our canines overcome their issues to assist them get adopted! Must attend a basic orientation previous to taking part. Class meets periodically and dates are posted on our Fb web page – or you’ll be able to contact volunteer@ for data on when the next class will be held.
View a listing of misplaced animals found throughout the final 5 days, together with the place they were discovered and which shelter they’re at now. Contact our Buyer Service staff on 131 872, Monday to Friday eight.30am – 5pm to ask if an animal matching your description could have been dropped at the Animal Administration Centre.
Cats have totally different personalities. Some prefer to be held and snuggled; others are more aloof and do not like to be picked up. So, be prepared to adapt to your new cat’s particular person personality traits. If you go to a shelter or contact a neighborhood rescue group to undertake a cat, they’ll be capable of advise you on the personalities of the cats in their care and enable you choose just the right cat for you.

domain: pet


text:
Port of Algeciras
This article needs additional citations for verification. (April 2021)
|Port of Algeciras|
|Location||Strait of Gibraltar|
|Annual cargo tonnage||107.30 million ( 1.70%) (2020)|
|Annual container volume||5.1 million TEUs ( 0.40%) (2020)|
The Port of Algeciras is the port and harbour of Algeciras, a city located in the province of Cádiz in the autonomous community of Andalusia, Spain. It is a commercial, fishing and passenger port. Primarily a transshipment port, its position near the Strait of Gibraltar and key east–west shipping routes establishes it as one of the busiest transshipment hubs in the world. It competes with Tanger-Med for the local transshipment market. It consists of numerous maritime infrastructures scattered throughout the Bay of Gibraltar. Although only the town of Algeciras and La Línea de la Concepción overlook the bay, there are port facilities in the rest of the bank, also belonging to the municipalities of San Roque and Los Barrios. It is managed along the port of Tarifa by the Port Authority of Algeciras Bay.
It is the largest port in Spain with almost 100 million tons in 2015  and largest in the Mediterranean Sea, and in 2018 was the 31st in the world in container shipping, and 33rd overall in 2019. In 2010 it exceeded 70 million tons in total traffic and more than 2.8 million containers. The port totals over 10 km of quays in different basins, which manage all types of passenger and freight traffic.
It is 7th busiest container port in the continent of Europe and 28th in the world with a trade volume of 2.81 million TEUs in 2010 (World Shipping Council) and 9th busiest port by cargo in Europe and 57th in the world with a cargo volume of 69,572,000 tons in 2008.
Unlike other major European ports, the present port is rather young. In ancient times the maritime shipping focused on Carteia, which was abandoned in the Middle Ages. During the Muslim presence in the Iberian Peninsula, Algeciras became the crossing point for crossing the Strait of Gibraltar. In the Reconquista the border area became the Moorish Kingdom of Granada, which caused it to be destroyed and abandoned in 1379. The population became concentrated in Gibraltar.
With the conquest of Gibraltar in 1704, the population fled and was distributed mainly along the bay. Several settlements were established, of which the only one on the banks of the sea was the repopulation of Algeciras. In the new distribution of the bay a port facility was not created until 1894, when a wooden jetty was created at the mouth of the Río de la Miel.
- Ceuta by Balearia, FRS and Trasmediterranea
- Tangier by Balearia, FRS, Inter Shipping and Trasmediterranea
- "UNLOCODE (ES) - SPAIN". service.unece.org. Retrieved 28 April 2020.
- "The Port of Algeciras closes 2020 with 107 Million Tonnes". www.apba.es. Retrieved 8 February 2022.
- Ministerio de Fomento-Puertos del Estado, «Récord histórico en los puertos, 501,8 millones de toneladas de mercancías.»
- C de Comunicación, «Estos resultados sitúan a los puertos españoles entre los cien primeros del mundo y los veinte más importantes de Europa. Así, Valencia se situó como 26º del mundo y 5º de Europa, Algeciras 42º y 8º, Barcelona 63º y 12º y Las Palmas 95º y 18º, respectivamente.»
- "Top 50 World Container Ports | World Shipping Council". www.worldshipping.org. Retrieved 22 September 2020.
- "One Hundred Container Ports 2019 :: Lloyd's List". Lloyds List. 26 August 2019. Archived from the original on 2019-08-26. Retrieved 22 September 2020.
- "Port of Algeciras Handbook". Global South European Maritime Hub. Archived from the original on 20 April 2012. Retrieved 24 May 2012.
- AAPA World Port Rankings 2008


text:
This function can be launched on a single sub-contracting order or on a selection of sub-contracting orders (EO), using the filters.
It is used to calculate the various costs corresponding to the various stages of the sub-contracting order in order to analyze the variances and the valuation choices in the production reporting. A single subcontracting order can be launched with this function, or an EO list of subcontracting orders that have been filtered can be launched with this function.
The different types of cost are as follows,
Expected theoretical cost :
In this case, the standard cost is calculated for the expected production quantity. When the standard data is used as the Variance calculation source, this cost is also included in the Production cost detail in the Planned column.
Provisional release cost:
As a provisional cost, it is based on the subcontract order data. If WO data is chosen as the Variance calculation source, it is equivalent to what appears in the Production cost detail in the Planned column. The Provisional theoretical cost and the Provisional releasecost are used to value the stock input of the sub-contracted product (according to the general setup CSTEORORD – EO receipt provisional cost). They are calculated either on demand or automatically during the creation and/or modification of the EO (according to the CLCWOCAUT – Auto provisional costs setup). The Provisional production cost can only be calculated for a closed EO.
Provisional sub-contracting cost:
The actual production quantity is used to calculate this cost, which is the same as the provisional release cost.
The “Calculate expected subcontract cost” is present in “Subcontract costs” under “Costing” menu.
All >> Costing >> Subcontract costs >> Calculate expected subcontract cost
A site, a filter criteria (EO closed or not) and a sub-contracting order must be specified.
There are three options in the Order number field as listed below,
Selection: It displays the sub-contracting order list corresponding to the filter criteria.
Released product filter: It displays a window used to do a selection using a filter on the table of released products.
EO filter: It displays a window used to do a selection using a filter on SCOHEAD table about sub-contracting order header.
After a filter selection is made, a calculation is launched for the work orders that meet the filter criteria. The filter box is checked for these work orders.
Cost type: An appropriate cost type must be specified for the calculation to be performed.
Overhead column choice: This type of overhead cost used depends on the column selected. By default, the choice displayed corresponds to that specified by the setup OVECOLSCO – PCP Calc Overheads Column.Calc. PRF
Update: This checkbox is activated to indicate that the provisional cost calculated upon release must be updated in the tables. Otherwise, it is simply a simulation.
Hope this helps!

domain: economics


text:
Located in the Adler City District of Sochi, Imeretinsky Valley, on the Black Sea, the Olympic Park houses the main Olympic Stadium used for the Games' ceremonies, and venues for indoor sports such as hockey, figure skating, curling, and speed skating. It also houses training facilities, the Olympic Village, the international broadcasting centre, and other amenities. The park is designed so that all of the venues are accessible within walking distance of each other. The venues are situated around a water basin containing a fountain known as "The Waters of the Olympic Park"; designed by California-based WET (which also designed the cauldron for the 2002 Winter Olympics in Salt Lake City), the fountain measures 5.3 meters in diameter with a capacity of about 700,000 gallons of water, featuring more than 250 nozzles and jet systems that can create fog and choreographed water displays set to music.
The Olympic Village is built in the Olympic Park, on the shores of the Black Sea. It was built by Basic Element. It consists of 47 buildings and is designed for three thousand people. Athletes, journalists and members of the Olympic family will live there. After the competition, the Olympic Village will be an off-season resort complex Sochnoye or "Juicy".
Coastal Cluster concept with all venues gathered around the Medals Plaza
Environmental protection measures are being used in venue construction. These include being climate-neutral, games in harmony with nature, zero waste, and raising environmental awareness in preparing and hosting the 2014 Games. The 100th environmental protection measure was completed in October 2010. Slopes at the Rosa Khutor Alpine Resort were completed on 26 November 2010. A European Ski competition will take place in early 2011 while a World cup event will take place in 2012.
In October 2010, it was announced that the area around the Coastal Cluster will be used as part of a Formula 1 racing circuit that will hold its first race in 2014. The Winter Games were completed with no problems and the first Grand Prix at the Sochi Autodrom took place on the 12th October 2014, which was won by Lewis Hamilton and the fastest lap was set by Valteri Bottas.
On 2 December 2010, FIFA (International Federation of Association Football) awarded their 2018 World Cup to Russia. Among the venues to be used will be Central Stadium (known as Sochi Olympic Stadium in Russia's bid package to FIFA), which will be expanded to seat 47,659 after the Games.


text:
We don't have a wiki here yet...
Black is the colour
Czarny kot (Black cat)
Maid on the Shore
Lord Galway's Lamentation
Leave a comment. Log in to Last.fm or sign up.
Discovery of the Week
11 Songs To Scrobble This Week
Watch Alex Winston Perform a Stripped Down Pop Session
Win Tickets To Laibach - Live In London!

domain: entertainment


text:
Medical Writers’ Circle
The Caring Ambassadors Lung Cancer Writers’ Circle provides information to help you and your loved ones make informed decisions about your health and are written by experts in the field of lung cancer from throughout the Country.
The Caring Ambassadors Lung Cancer Program provides the Caring Ambassadors Lung Cancer Medical Writers’ Circle to the lung cancer community as a primary means of fulfilling our mission of enhancing the information available to people affected by lung cancer.
Blood-based biomarker testing aid in the early diagnosis of lung cancer
James Jett, MD & Steven Springmeyer, MD, FCCP
Caring for One’s Self During the COVID-19 Crisis
Susan Hedlund, LCSW, OSW-c, FAOSW
Use of cannabinoids in cancer care: palliative care
S.K. Aggarwal, MD PhD
Lung Cancer and Social Security Disability Benefits
Social Security Disability Help
Breathing_Strong Muscles Can Decrease Shortness of Breath
Donna Wilson, RN, MSN, RRT
Emma Patrick and Jessica Steinberg
Comparative Effectiveness in Lung Cancer Management Time for Change
Frederic W. Grannis Jr. M.D.
Complementary and Alternative Medicine Focus on Chinese Traditional Medicine
Misha Ruth Cohen, OMD, L.Ac.
Detecting Lung Cancer with Chest Xrays
The Diagnosis and Staging of Lung Cancer
Tze-Ming Chen, MD, George Horng, MD, Kevin Knopf, MD, Stephen Bunker, MD, Jacqueline Duffy, RN, and Peter Anastassiou, MD
Early Detection of Lung Cancer
William C. “Bud” Pierce, MD, PhD
EML4-ALK: Newly Discovered Mutation Brings New Insights and New Potential Treatment
Howard “Jack” West, MD
Emotional Effects of Lung Cancer on Survivors and Their Spouses
Cindy L. Carmack, Ph.D., Associate Professor, The University of Texas M. D. Anderson Cancer Center
Epigenetic Therapy for Lung Cancer
John M. Wrangle MD, MPH
Facing Existential Issues Following a New Diagnosis of Lung Cancer
Rebecca Lehto, PhD, RN
How to Apply for Social Security Disability with Lung Cancer
Mollie Clarke, Writer for Social Security Disability Help.
It is Never Too Late to Quit Smoking – Lung Cancer Diagnosis Withstanding!
By Carol Southard, RN, MSN
Lung Cancer in Never-Smokers
Heather Wakelee, MD, Assistant Professor of Medicine, Division of Medical Oncology Stanford, University Stanford Cancer Center
Lung Cancer Workshop – Progress Toward Translation
Contributed by: Evi Bachrach Makovsky, Merel Grey Mountain, Kim Norris, Christie Pratt, Elda Railey and Deb Violette
The MAGRIT: (MAGE-A3 as Adjuvant Non-Small Cell LunG Cancer Immunotherapy)
Mathew Ninan, MD, FACS, FRCS(C/Th), FETCS, MSCI. Midsouth Regional Thoracic Center Memphis, Tennessee
Physical Activity and Lung Cancer Survivorship
Dr. Lee W. Jones is an Associate Professor in the Department of Radiation Oncology and Research Director of Cancer Survivorship at Duke University Medical Center.
Practical Implications Of The New Lung Cancer Staging System
Rodolfo E. Bordoni, MD
Smoking Cessation An Integral Part of Lung Cancer Treatment
Janine Cataldo, PhD, RN, as Assistant Professor, Department of Physiological Nursing at the University of California, San Francisco
Some observations and recommendations on the management of lung cancer patients with more than one tumor..
Frederic W. Grannis Jr. M.D., Clinical Professor of Thoracic Surgery, City of Hope National Medical Center
Stacked Stigma in the Lung Cancer Experience
Annemarie Conlon, MBA, LCSW
Tailoring Mindfulness-Based Therapies During Lung Cancer Treatment
Rebecca Lehto, PhD, RN
Targeting the Immune System to Treat Small Cell Lung Cancer
Alberto A. Chiappori, MD
The Truth About Lung Cancer, A Surgeon’s Perspective and Commentary
Jonathan Kiev, MD, Sibley Memorial Hospital, John Hopkins Medicine
Twice Betrayed Living with Lung Cancer and Dealing with Stigma
Susan Hedlund, MSW, LCSW
Light in the Darkness, The Role of the Patient Navigator
Brenda Wilcox, RN, BSN, OCN
Lung Cancer, Again
The information provided in the Caring Ambassadors Lung Cancer Medical Writers Circle is not medical advice and is not intended to replace or supersede any information your doctor may have given you.
All health care decisions should be made with your doctor. No changes in your health care treatment, management, or medications should be undertaken without first discussing the safety and probable outcomes of such changes with your doctor.


text:
Ask an Expert
free call 1300 720 000
9am - 5:30pm Monday - Friday
What an absolutely wonderful time we had on the Annapurna Trek ...The WE staff and especially Dilli the tour leader were great. I canít speak highly enough of them. Dilli was very knowledgeable, helpful and nothing was too much trouble. The cook did a great job. The food was plentiful and tasty.
From the time we left home until the time we got back everything ran smoothly. Even the weather was good. I thoroughly enjoyed my time in Nepal and hope to get back there in the future...I have no hesitation in recommending WE to friends.
Adventure Travel Information Nights
World Expeditions invites you to attend our inspiring Adventure Travel Info Nights. These special evenings are designed to inform and entertain and are hosted by our most experienced and passionate adventure travellers and mountaineers.

domain: travel


text:
Long Owl of Hookland
Add to Cart
This linocut was inspired by the Long Owl of Hookland, a chalk figure carved into the hills of Hookland, thought to be lost by many for a long time.
'When the giant eyes of the Lost Owl blinked open for the first time in more than two hundred years, I was one of those climbed the hill and held hands with 20 others inside the oval shapes they made. We trod carefully, we came in reverence. Offerings were left. My heart called out the words folkore has gifted us: 'Hail to the Queen of Owls! Grant me a feather of your wisdom! Grant me three drops of your talon-blood to cure or curse!'
Emily Banting's 'Cunning County'; published in Issue 1 of ‘Rituals and Declarations’ zine, reproduced with permission of David Southwall of the Hookland Folklore Society.
Limited edition of 17 numbered linocut prints, printed with water-based relief printing ink (black) on acid-free cartridge paper, 190gsm
300mm x 210mm approx. / 11.6 inches x 8.2 inches approx.
200mm x 113mm approx./ 7.7 inches x 4.5 inches approx.
Note: Your print may vary slightly from the picture shown, as each is individually printed by hand and is unique.
10% of every sale of this print go to @HooklandGuide
Updating Order Details
Please do not refresh or navigate away from the page!
No Reviews Posted Yet - be the first!
Product Added to your Cart
proceed to checkout
-------- OR --------
Modal Dialog Title
Modal Dialog Content
Create a free online store
Powered by freewebstore.com
Get your free online store today - Be your own boss!
Got a great business idea?
Get a free online store just like this one!
What do I get?
Hosted online store
Domain & SSL
650k stores created
No card required
Easy to create
What's the catch?
Feature upgrades available


text:
Speeding fines to increase to £2500 maximum penalty
As if you don't already keep your eyes peeled for speed cameras, there's now even more incentive thanks to a change in the law which could see motorists hit with a new £2500 penalty.
The updated law, which comes into effect as of April 24th, is the result of a consultation in 2016, which came to the conclusion that previous guidelines don't reflect the harm and damage speeding can cause. Of course, points on your license are still a thing.
“The magistrates' courts deal with the vast majority of offenders in England and Wales, so it is essential that the guidelines they use are up to date and help ensure that sentences are applied consistently and effectively,” said district judge Richard Williams, a sentencing council member.
The new £2500 max penalty is a significant increase over the previous £1000.
According to the Sentencing Council, the change has been brought in to create a “clear increase in penalty as the seriousness of offending increases,” the Mirror reports.
There are three bands which determine how heavily a driver will be fined:
Band A a motorist will be charged half their weekly income.
Band B will be a full week’s earnings.
Band C is set for 150 per cent.
The government hope an increase in fines will combat the reduction in the number of dedicated road traffic police officers.
According to the RAC, excessively breaking the speed limit puts lives at risk and causes danger to every other road user.
“Hopefully, hitting these offenders harder in the pocket will make them think twice before doing it again in the future,” spokesman Pete Williams said.

domain: law


text:
WINDY CITY TIMES
||2nd Ward Race a Dogfight
This article shared 4080 times since Wed Apr 11, 2007
It's a fight to the finish in the race involving incumbent 2nd Ward Alderman Madeline Haithcock and challenger Bob Fioretti, with everything from name-calling to stalking charges being bandied about.
Last month, Haithcock sent out 13,000 mailings that had the word 'stalker' on them—and that featured Fioretti's picture on them, CBS-2 reported. Fioretti followed up by filing a lawsuit, claiming libel. The mailings referred to a restraining order filed four years ago against Fioretti.
However, that restraining order led the National Organization for Women ( NOW ) to rescind its support for Fioretti—for a second time. Initially, NOW supported Fioretti, but then changed its mind and took back its endorsement days before the primary election on Feb. 27, citing the order. In late March, the organization again decided to back Fioretti, but then again took back its endorsement after feeling that he was misleading regarding his relationship with the woman who filed the order.
This article shared 4080 times since Wed Apr 11, 2007
| ARTICLES YOU MIGHT LIKE|
|Treasurer Frerichs honors Illinois leaders during Women's History Month 2021-03-01|
--From a press release - SPRINGFIELD — In honor of Women's History Month, Illinois State Treasurer Michael Frerichs today kicked off a virtual campaign to highlight and celebrate the achievements of women in Illinois. This year's national theme for Women's Histo ...
|WORLD Ghana turmoil, Malaysia case, Copenhagen 2021, Brazil churches 2021-02-28|
- Anti-gay outcry has forced Ghana's first LGBT+ community center to temporarily close to protect its staff and visitors three weeks after it opened, Reuters reported. Church groups, politicians and anti-gay rights groups have called on the ...
|Equality Act would provide federal civil rights protections to 13M LGBTs 2021-02-26|
--From a press release - Today, the U.S. House of Representatives passed the Equality Act, federal legislation that would expressly prohibit discrimination based on sexual orientation and gender identity under existing civil rights laws. LGBT ...
|ELECTIONS Chicago alderman exploring secretary of state run 2021-02-26|
- According to Politico Playbook, Chicago Ald. Pat Dowell (3rd Ward) is exploring the possibility of running for secretary of state. I know I can build on the work that Secretary [of State Jesse] White has done ...
|Harris reveals legislative agenda for 2021 2021-02-26|
--From a press release - With remote committee hearings starting next week, the Spring Session is now truly underway. I wanted to share my legislative agenda for this year with you. In addition to my duties as chief budget negotiator for ...
|Mike Madigan picks second successor
- On Feb. 25, Angelica Guerrero-Cuellar was sworn in as the new 22nd District state representative, media outlets reported. Guerrero-Cuellar is the second person to succeed now-former Illinois House Speaker Mike Madigan in less than a week. ...
|House passes Equality Act, LGBTQ Victory Institute demands Senate vote 2021-02-25|
--From a press release - Washington, DC — Today LGBTQ Victory Institute — the only national organization dedicated to supporting LGBTQ elected officials — applauded the U.S. House for passing the Equality Act and called on U.S. senators not to filibuster ...
|Vaccine eligibility opens to Illinoisans with serious medical conditions 2021-02-25|
--From a press release - CHICAGO — Building on efforts to equitably distribute the COVID-19 vaccine, Governor Pritzker and the Illinois Department of Health today announced that Illinoisans with serious medical conditions can be vaccinated ...
|Dr. Rachel Levine confirmation hearing today, to be first trans Senate-confirmed appointee 2021-02-25|
--From a press release - Washington, DC — Today Dr. Rachel Levine will testify before the U.S. Senate Committee on Health, Education, Labor and Pensions about her experience and qualifications to be the next U.S. Assistant Secretary of Health. If moved ...
|Victory Institute condemns Rand Paul attack on
Dr. Rachel Levine, trans youth 2021-02-25|
--From a press release - Washington, DC — Today LGBTQ Victory Institute condemned Senator Rand Paul's transphobic attack on Dr. Rachel Levine during her confirmation hearing before the U.S. Senate Committee on Health, Education, Labor and Pensions. He attacked trans you ...
|Advocates, legislators introduce bill to
decriminalize HIV in Illinois 2021-02-25|
--From a press release - SPRINGFIELD, IL - Legislation was introduced in Springfield this week to end criminal penalties against people living with HIV (PLWH), which serve only to stigmatize and discriminate against PLWH. Current Illinois law makes legal behavior — ...
|Three Illinoisans among Victory Fund's latest endorsed candidates
- On Feb. 24, LGBTQ Victory Fund—the only national organization dedicated to electing LGBTQ leaders to public office—issued a press release announcing its endorsement of 30 more LGBTQ candidates for 2021 races. Illinois candidates in the group ...
|Daniel Biss wins Evanston mayoral race
- Former Illinois state Sen. Daniel Biss, a Democrat, won the Evanston mayoral race on Feb. 23, media outlets reported. An hour after polls closed, Biss had collected more than 73 percent of the votes counted and ...
|Mike Madigan now wants successor to step down
- Just two days after appointing Edward Guerra Kodatt as his successor, former Illinois House Speaker Mike Madigan has asked him to step down, according to various media outlets. Marty Quinn, alderman of Chicago's 13th Ward, joined ...
|1.3 million adult immigrants in the US identify as LGBT
--From a press release - LGBT immigrants are more often male and younger compared to all immigrants in the country An estimated 1,274,500 LGBT foreign-born adults live in the U.S., including 289,700 who are undocumented and 984,800 who are documented, according ...

domain: politics


text:
Heartbroken Poems Can Help You Heal A Broken Heart
Writing heartbroken poems is a good way to get over a break up with a person you love. Perhaps you have written sad poems before after you lost someone special – a pet, a friend, or maybe you had some changes in your life, like moving away or other sad events.
It is so easy to allow slights and small mis-communications create distance between you and your mate. Read this from a woman’s point of view how to avoid the pitfalls.
Growing Up in a Polygamous Home – Challenges and Conflicts
I grew up in a polygamous home. There were competitions all the time between the two families. As a young girl, I never understood why my father was never home and when he did, it was very briefly. My mother and her children lived close to my grandmother’s home. My stepmother lived about five miles away. All of us children attended the same primary school.
How to Make Love to Him in a Way That He Will Never Forget? Here Are the Tips You Need to Know
Imagination and creativity are keys to setting the stage if you want to make love to him in a way that he will never forget. So indulge in the few tips given here.
Love in the Bible Stories of Creation (Adam and Eve)
Love in the Bible stories can be found in the genesis Old Testament bible creation and life story of Adam and Eve. This online short article stories will give you one important relationship tip that you can not go without.

domain: literature


It's the middle of the week and as always Wednesday sees Lammo welcome another New Favourite Band into the studio. This week its London duo Friendship. Wednesday also sees Steve chatting with another Good Day Bad Day Caller to find out about their musical history. They'll be another National Anthem, the final Lost 45 of the week and, as it's the programmes 5th Birthday some special live guests in the studio with Steve! Plus, music from the likes of Embrace, Grandmaster Flash and We Are Scientists.


text:
Villa on the fjord (Villa)
Villa on the fjord (Villa). The wonderful House on the Fjord is situated on the island of Bomlo, a beautiful rural area off the west coast of Norway, connected to the Norwegian mainland by a tunnel. Built on the shores of the Adnanes Fjord overlooking the sea, mountains, and islands and surrounded by green meadows, lush forests, and fjords, this house offers a truly unique experience of Scandinavian living.
This is a place for nature lovers and for those looking for peace and quiet along with outdoor activities, pampering and gourmet food. The weather is unpredictable and can include rain and wind as well as beautiful sunshine, clear skies, and velvet evenings. Summer temperatures (from mid-May) rise to 25C with the sun rising at 4 am and setting around 11 pm.
The villa is spacious and airy. A terrace runs the length of the house and is furnished with deck chairs and a Jacuzzi, heated to 39C all year round. Contemporary in design and décor with modern, marble bathrooms, the house offers easy, laid-back living along with professional staff and a gourmet chef. More


My dad recently got a new lease for a car which replaces his tried-and-true, 20-year-old truck. As soon as he gets a new toy he always enjoys pressing all the buttons and seeing what kind of weird things he can do. Recently, he’s been playing with the changing the speaker output for any kind of music or sound and messing with his passengers. It reminds me of playing with the equalizer on an old analog stereo system. Those knobs back then were connected to a filter circuit.
Of the various types of filters, low pass filters are very important for producing clean signals in a number of systems. So what is the easiest way to see examine the behavior of a particular low pass filter? This is low pass filter transfer functions come in handy.
Low Pass Filters and their Transfer Functions
As its name implies, a low pass filter is an electronic device that allows low frequency AC signals to pass a current through the filter circuit. The output from the filter circuit will be attenuated, depending on the frequency of the input signal. A number of different active and passive components can be used to construct filter circuits with various characteristics. Some filters include low pass, high pass, bandpass, all-pass elliptical, Chebyeshev, and Butterworth filters.
The easiest way to summarize the behavior of a filter is to define a transfer function. The transfer function tells you how the output signal is related to the input signal at various frequencies. If you are designing a filter circuit, you can easily determine the transfer function from a graph of the output signal at various frequencies. You can also calculate the transfer function using Kirchoff’s laws to derive the differential equation that governs the circuit.
Definition of a transfer function, its magnitude, and phase for a sinusoidal signal
As a signal passes through a filter, the filter will apply some phase shift to the output signal with respect to the input signal. This means that a transfer function for a filter is a complex function of frequency, and the transfer function contains all the information you need to determine the magnitude of the output signal and its phase. The general definition of a transfer function, its magnitude, and its phase are shown in the image above. Once you know the transfer function for a filter, you can convert this to a Bode plot to get a view of the transfer function in dB.
If this idea of a transfer function that defines the behavior of a filter is unfamiliar, it is convenient to think of the transfer function in terms of impedance. Just like impedance is a complex number that defines frequency-dependent resistance, a transfer function defines frequency dependent attenuation or gain. Instead of relating the output current and input voltage as you would with Ohm’s law, you are simply changing the value of the input voltage to some other value. Low pass filter transfer functions essentially have increased attenuation as frequency increases.
Higher Order Low Pass Filter Transfer Functions
In particular applications, you might find that the roll-off in the transfer function of a low pass filter is not steep enough. This means that there is still some high frequency content that is allowed through the filter and appears in the output signal. If you need better filtration of these higher frequencies, you can create a higher order filter by cascading multiple filters together in series. In general, a simple filter constructed from an RLC or similar circuit is called a first order filter. Two first order filters that are connected in series is called a second order filter, and so on...
A higher order filter is like a stack of coffee filters
If you look at higher order low pass filter transfer functions, you’ll find that the transfer function has a steeper roll-off at higher frequencies. This is very useful for suppressing noise with high frequency content. One example involves gathering a signal from a sensor array that may be sensitive to RF frequencies. If you pass the signal through a low pass filter, you can significantly suppress RF signals at higher frequencies. Mid-range and high frequencies will be suppressed to a greater extent when you use a higher order filter.
More General Transfer Functions
Note that a transfer function is often defined in terms of the Laplace transform for the differential equation describing a circuit. However, you can write the transfer function in terms of the frequency of a sinusoidal source using the equation shown above. This is done by substituting s=iω into a typical transfer function. This gives you a convenient view of the transfer function for individual frequencies.
In the case of a harmonically driven circuit that is not driven away from equilibrium, the transfer function can be easily determined by simply taking the Fourier transform of the differential equation describing the circuit. Using the Laplace transform to derive the transfer function is normally preferable in systems that include feedback, thus you would need to determine whether the system is stable. Unless you are designing a low pass filter with active feedback (e.g., a Butterworth filter), there is no element of stability to be considered under sinusoidal driving, thus the Fourier approach is suitable for most applications.
If you use an AC frequency sweep with a SPICE package and measure the output voltage from your low pass filter, you can determine the magnitude and phase at each driving frequency and construct a plot of the transfer function in the frequency domain. Determining the transient response of a circuit requires using looking in the time domain under impulse driving or step function driving.
Operational amplifiers appear in a number of filter circuits
Finally, when working with active components, you can use a time domain analysis for the circuit at different frequencies if you want to examine stability. This is somewhat time consuming because you are examining the effects of two parameters. If you perform a frequency sweep, you may see a peak in the transfer function near the circuit’s natural frequency, corresponding to gain in the system near cutoff.
Determining the transfer function and creating a bode plot for any circuit and with any type of source is much easier when you use a powerful SPICE package that simplifies frequency domain analysis of complex circuits. The OrCAD PSpice Simulator package from Cadence allows you to perform frequency sweeps, transient analysis, and many other tasks that are important for designing and analyzing analog circuits for any application.
This unique package is adapted to complex PCB designs, interfaces directly with your design data and helps you generate transfer functions for your filter circuits.
If you’re looking to learn more about the solutions Cadence has for you, talk to us and our team of experts.


Overturned trailer shuts down large portion of EB Basin Bridge
PORT ALLEN - An overturned trailer shut down a large portion of the eastbound Atchafalaya Basin Bridge for several hours.
According to DOTD, the trailer overturned in the I-10 median before 2 a.m. Wednesday morning. Crews shut down the Interstate from the North Lobdell Highway exit to the Whiskey Bay exit to expedite clearing.
Officials reported the crash resulted in minor injuries.
Traffic was diverted at I-49 in Lafayette. All lanes were reopened shortly after 6 a.m..
Desktop NewsClick to open Continuous News in a sidebar that updates in real-time.
Proposed Louisiana bill could eliminate parole for offenders in the future
'No room!' - More than 30 Southern University students forced out of...
Springfield Road in Watson still under construction, completion expected in May
Insurance Commissioner Tim Temple discusses approach to insurance crisis
Plans for LSU entertainment and sports arena moving forward


text:
Nintendo has revealed more about the virtual reality experiences that you can build and interact with in the Nintendo Labo VR Kit.
These experiences have all been designed to be shareable, fun, and social, with each Toy-Con once again looking to combine tactile feedback in the real world with virtual adventures.
The Toy-Con Wind Pedal, for example, produces a blast of air to recreate the feeling of flying, whereas players can charge the Toy-Con Blaster before launching a volley of lasers (or fruit).
The games and experiences that you can expect to play with the different Toy-Con creations include:
- Bird: Soar through the sky on a bird’s back, collecting items and helping baby birds hatch along the way. When using the Toy-Con Bird, players can flap its wings. But a tap of the Toy-Con Wind Pedal delivers a surprisingly strong puff of air to the player as the bird in the game gets an extra boost of speed.
- Bird Dash: Compete in timed challenges by racing through checkpoints as you fly through the sky.
- Blaster: Battle an alien invasion and giant bosses in an on-rails experience that requires sharp reflexes and a keen eye.
- Kablasta: Challenge a friend to competitive hippo feeding! Fling different types of fruit toward the hippos to lure them toward your side of the pool and score the most points.
- House Camera: Interact with the strange creature living in the house – which some people may recognize from the Nintendo Labo: Variety Kit! – and complete missions by taking photos in its mysterious home.
- Ocean Camera: Dive into the deep blue virtual sea and complete objectives like taking photos of sea life. The ocean is full of surprises.
- Doodle: Create colorful 3D artwork by moving the trunk of the Toy-Con Elephant through the air, using various in-game tools and styles to bring your creations to life. Once finished, show off your masterpieces on the TV by docking your Nintendo Switch. An additional multiplayer game lets players take turns drawing and guessing each other’s drawings.
- Marble Run: Try to complete physics-based puzzles by using various objects to guide marbles through rings. You can even create puzzles of your own to challenge friends and family.
Toy-Con Wind Pedal
- Hop Dodge: As a frog, jump as high as you can on an ever-growing stack of colorful balls while avoiding obstacles and heading soccer balls. The wind resistance from the Wind Pedal will make you feel as though you’re actually experiencing a breeze.
- VR Plaza: Enjoy 64 bite-sized games and experiences in VR Plaza, including platformers and puzzlers. Many of these experiences can be enjoyed using only the Toy-Con VR Goggles and Nintendo Switch system.
You can then use Toy-Con Garage as well as the new Toy-Con Garage VR to create your own VR games and experiences, which the development team used to create the 64 bite-sized games and experiences for VR Plaza.
When the Nintendo Labo VR Kit releases next month, it will be available in two configurations – one that contains all the Toy-Con creations, and another with a few for you to get started with.
The Nintendo Labo VR Kit ($79.99) will include the software and materials to build all six Toy-Con projects – the Toy-Con VR Goggles, Toy-Con Blaster, Toy-Con Camera, Toy-Con Bird, Toy-Con Wind Pedal and Toy-Con Elephant – as well as a Screen Holder and Safety Cap.
Whereas the Nintendo Labo VR Kit Starter Set + Blaster ($39.99) will have the software and components to build the Toy-Con VR Goggles and Toy-Con Blaster, as well as the Screen Holder and Safety Cap.
And then, for those that choose the Starter Set, you can expand your experience with the Nintendo Labo VR Kit Expansion Set 1 ($19.99) and Nintendo Labo VR Kit Expansion Set 2 ($19.99) – which come with the Toy-Con Elephant and Toy-Con Camera or Toy-Con Wind Pedal and Toy-Con Bird, respectively.
The Nintendo Labo VR Kit Starter Set + Blaster, complete Nintendo Labo VR Kit, and Expansion Sets will release at retail worldwide on April 12th.


There have been about 500 lawsuits filed against Johnson & Johnson (J&J), regarding their popular antipsychotic drug Risperdal for bipolar disorders, schizophrenia and autism. Many patients are facing a new diagnosis – diabetes, in addition to gynecomastic (abnormal breast growth in children and adults). It is anticipated that thousands more cases could be filed in the coming year, leading to a widespread settlement.
According to Bloomberg (January 2012), a witness testified that J&J, the maker of Risperdal, hid three studies from the U.S. Food and Drug Administration (FDA) showing some patients using Risperdal developed diabetes, while at the same time saying the antipsychotic drug did not cause the disease. The first study in 1999 had researchers at J&J’s Janssen unit reporting about 50 percent of patients taking Risperdal in a study developed diabetes after one year on the drug.
That study determined Risperdal caused “medically serious weight gain” that led study subjects to develop diabetes.
Dr. Joseph Glenmullen, psychiatrist and Harvard Medical School instructor, testified on behalf of the state of Texas that filed a lawsuit over Janssen’s marketing of the drug. During the trial, Glenmullen said that Janssen salespeople were telling doctors that researchers concluded the drug did not cause diabetes. In 2011, a South Carolina judge ordered Janssen to pay more than $327 million in damages over its Risperdal marketing practices in that state.
Last month a judge in the Philadelphia Court of Common Pleas ruled that plaintiffs in the current Risperdal lawsuits could not be awarded punitive damages. And in another blow for plaintiffs, J&J has asked the judge to rule that the statute of limitations has run out on hundreds of claims filed against the Risperdal maker.
In its May 19 motion for summary judgment, Janssen Pharmaceuticals argued that plaintiffs were filing cases years and sometimes decades after they were aware of problems with the drug, and even long after they were aware of their own injuries.
Researchers have reported this year that Risperdal can cause children to develop type II diabetes at three times the normal rate. This puts them at risk for a lifetime of vision, hearing, skin and blood pressure issues.
“Based on the undisputed facts, Janssen respectfully requests that the court find that, for purposes of the statute of limitations, all plaintiffs were on inquiry notice of a potential connection between Risperdal use and gynecomastic no later than October 31, 2006,” Janssen wrote.
J&J has been fined more than $1.2 billion for alleged false marketing of Risperdal for uses not approved by the FDA and for failing to warn consumers that the drug was defective and dangerous.
However, Janssen has already settled approximately 80 lawsuits in Philadelphia and trials in a new set of cases are expected to begin in July, according to court records.
If you or a loved one has taken Risperdal and is now diagnosed with diabetes, you may be entitled to compensation for your damages. For more information, contact one of our Gacovino Lake attorneys at 1-800-246-HURT (4878).