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In response to DNA damage eukaryotic cells activate a series of DNA damage-dependent pathways that serve to arrest cell cycle progression and remove DNA damage. where an ATR phosphorylation site (serine 196) is located. XPA-deficient cells complemented with XPA containing a point mutation of S196A displayed a reduced repair efficiency of cyclobutane pyrimidine dimers as compared with cells complemented with wild-type XPA although no effect was observed for repair of (6-4) photoproducts. This suggests that the ATR-dependent phosphorylation of XPA may promote NER repair of persistent DNA damage. In addition a K188A point mutation of XPA that disrupts the ATR-XPA interaction inhibits the nuclear import of XPA after UV irradiation and thus significantly reduced DNA repair efficiency. By contrast Rabbit polyclonal to CaMK2 alpha-beta-delta.CaMK2-alpha a protein kinase of the CAMK2 family.A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.. the S196A mutation has no effect on XPA nuclear translocation. Taken together our results suggest that the ATR-XPA interaction mediated by the helix-turn-helix motif of XPA plays an important role in DNA-damage responses to promote cell survival and genomic stability after UV irradiation. The genomes of all living cells are under constant attack from both endogenous and exogenous agents that may lead to genome instability. The nucleotide excision repair pathway (NER)3 is the primary mechanism in cells for the removal of bulky DNA lesions induced by exogenous agents such as UV radiation and a variety of genotoxic chemicals (1). In eukaryotic cells NER needs a lot more than 25 proteins to execute the DNA harm reputation excision and DNA synthesis measures necessary to take away the lesion and restore the integrity of DNA (2 3 In human beings problems in NER result in the medical disorder Xeroderma pigmentosum (XP) that’s characterized by improved level of sensitivity to UV light and a predisposition to advancement of skin tumor (4 5 Xeroderma pigmentosum group A proteins (XPA) is among eight factors discovered to be deficient in XP disorder (2 3 6 XPA is a 32-kDa zinc metalloprotein that Kenpaullone is believed to verify the damage site after initial recognition of the presence of Kenpaullone a lesion stabilize repair intermediates and play a role in recruiting other NER factors (7-13). XPA is an indispensable factor for both the transcription-coupled repair and global genome NER pathways. Given its central role in NER patients with XPA deficiency display the most severe XP phenotypes (2 3 In addition XPA has also been implicated to play a role in laminopathy-induced premature aging syndromes (14 15 The DNA damage checkpoint pathways serve to monitor genomic integrity and to coordinate multiple cellular pathways to ensure efficient repair of DNA damage (16). The ATM (ataxia-telangiectasia mutated) and ATR (ATM and RAD3-related)-mediated checkpoint pathways represent two major DNA damage-dependent checkpoints. Both ATM and ATR are protein kinases belonging to the phosphoinositide 3-kinase-like kinase family. These pathways are composed of a series of DNA damage sensors signal mediators and transducers and downstream effector molecules (1 16 17 The ATR-dependent checkpoint pathway serves to sense replication stress and responds primarily to DNA damage typically generated by UV irradiation (1 18 ATR is targeted to the sites of elongated RPA-coated single-strand DNA generated when DNA replication forks stall because of DNA Kenpaullone damage. This event is mediated Kenpaullone by interactions between RPA and the ATR interaction protein ATRIP (18). Upon sensing DNA damage ATR initiates a complex signaling cascade via phosphorylation of downstream protein substrates which ultimately leads to cell cycle arrest (20 21 Previous studies have implied a role for the ATR-mediated checkpoint pathway in regulation of the NER pathway (17 22 23 In particular ATR kinase activity may participate in the regulation of global genome NER uniquely during the S-phase of the cell cycle. Additionally XPA has been defined as a direct ATR target for phosphorylation and cytoplasm-to-nucleus redistribution in response to UV-C irradiation (22). XPA?/? cells complemented with recombinant phosphorylation-deficient XPA protein displayed an increased sensitivity to UV-C irradiation compared with cells complemented with wild-type XPA (22). In addition ATR directed the nuclear import of XPA in both a dose-dependent and time-dependent manner for regulation of NER activity (17). Although there is growing evidence that the ATR-dependent checkpoint pathway coordinates with NER via an ATR-XPA interaction to promote.
Background The outcomes of total knee arthroplasty (TKA) in patients with inherited bleeding disorders (IBDs) are poorer when compared with those in the general population with a notably higher risk of complications and higher revision rates. of the implant. However inferior results were found in cases with contamination. Volasertib All patients operated on for aseptic loosening required only single-stage TKA whereas patients with contamination underwent multiple interventions. Complications were observed only in cases with contamination. Conclusions Our study clearly outlined the differences in results based on failure mode with far inferior results obtained in cases with contamination. Given the lack of data in this area as well as the high specificity of this population further high-quality studies are needed. MeSH Keywords: Arthroplasty Replacement Knee; Blood Coagulation Disorders; Reoperation Background Inherited bleeding disorders (IBDs) constitute a group of rarely occurring coagulation disturbances caused by deficiency or improper function of blood clotting factors. The three most common IBDs are hemophilia Volasertib A hemophilia B (Christmas disease) and von Willebrand disease (VWD) which are triggered by the absence of coagulation factor VIII (FVIII) coagulation factor IX (FIX) and von Willebrand factor (VWF) respectively. The clinical course of IBD is usually dominated by spontaneous bleeding episodes leading to irreversible destruction of affected joints. Severe arthropathy remains the major cause of morbidity for hemophilia and the knee is the most commonly involved joint [1-6]. Total knee arthroplasty (TKA) is the only way to get rid Volasertib of the progressive discomfort and enhance the standard of living in end-stage arthropathy from the leg joint. Regarding to previously released reports it could offer satisfactory leads to most hemophilia sufferers with 10-season prosthetic survival price of 83-92% [7-13]. However the leads to this band of sufferers are poorer in comparison to those in the overall population using a notably higher threat of problems and higher revision prices [1 7 Because of this in the wake from the continuous upsurge in the amount of principal TKA in hemophilia sufferers revision procedures have become an evergrowing concern. The primary goal of the scholarly study was to judge the results of revision TKA in patients with IBD. Within this paper we talk about our knowledge and put together our method of the administration of failed TKA within this tough patient population. It ought to be emphasized that world-wide experience with this matter is quite limited also to the very best of our understanding this is actually the initial paper in the books specialized in this compelling issue. Material and Strategies This retrospective cohort research with longitudinal evaluation of hemophilia sufferers scheduled to get revision TKA was performed in the Section of Orthopedic Medical procedures and Traumatology from the Central Analysis Hospital from the Ministry from the Poor in Warsaw Volasertib an orthopedic middle for sufferers with IBD. Volasertib All hemophilia sufferers operated on due to TKA failing between January 2010 and Sept 2015 were examined in this scientific series. The analysis was accepted by the moral review plank and up to date consent for printing and digital publication of final results was supplied by all sufferers. The analysis group contains nine hemophilic guys aged 41 to 62 years (mean age group: 49.9 years). Eight sufferers had serious hemophilia A and one affected individual had been identified as having a severe type (type 3) of VWD. There have been no patients with clotting factor inhibitor in the scholarly study group. One patient needed treatment in both legs five sufferers underwent left-sided techniques seven from the sufferers signed up for this study had been primarily controlled on in various other clinics and two patients underwent main TKA in our department (cases 7 and 9). Four cases were operated on because of aseptic loosening of the implant whereas periprosthetic joint contamination was reported in five cases (six knees). In the study group none of the IKK-gamma (phospho-Ser85) antibody patients were seropositive for human immunodeficiency computer virus (HIV) eight of nine patients were seropositive for hepatitis C computer virus (HCV) and two patients were seropositive for hepatitis B computer virus. The mean body mass index (BMI) was 25.48 kg/m2 with three overweight (BMI: 25-29.9 kg/m2) patients one moderately obese (BMI: 30-34.9 kg/m2) individual and no underweight (BMI: <18.5) patients. Patient demographics and relevant co-morbidities are offered in Table 1. Table 1.
Erection dysfunction (ED) is the most common male sexual dysfunction and shares many risk factors with systemic conditions including cardiovascular disease (CVD) and the metabolic syndrome (MetS). of the relationship between ED the MetS and CV risk and how this effects the approach to the patient presenting with ED. assessed seven classic CVD risk factors in male subjects and consequently evaluated these males for ED 25 years later on. Mean age BMI cholesterol and triglycerides were all significantly associated with an increased risk of ED (5). A review of the Massachusetts Male Aging Study (MMAS) exposed that after modifying for age a higher probability of ED correlated with a history of prior heart disease hypertension and diabetes (6). A follow-up study revealed that cigarette smoking almost doubled the likelihood of moderate or total ED (7). In obese males with a sedentary lifestyle a significantly higher incidence of ED is definitely observed than in normal males (8). Obesity also increases the risk of ED like a function of BMI. A multivariate analysis performed inside a cohort study of 22 86 American males found that compared to males with BMI <25 kg/m2 those with a BMI of 25-26.9 kg/m2 had a 19% increased risk of developing ED while those with BMI 27-29.9 kg/m2 had a 33% increased risk of developing ED (9). The link between ED and another known CVD risk element diabetes mellitus is also strong. Males with both type 1 and type 2 diabetes are at increased PNU-120596 risk of ED when compared with nondiabetic males (10). The prevalence of ED in diabetic males ranges from 35-90% (11). Kalter-Leibovici observed severe ED in nearly one third of males with diabetes and mentioned that ED worsened in severity with both improving age and diabetes duration (12). Links to CVD A study of 300 males with angiographically recorded coronary artery disease (CAD) found that 49% suffered from ED. The study by Montorsi examined the incidence of asymptomatic CAD in individuals with non-psychogenic non-hormonal vasculogenic ED. Ultimately 19 of subjects were found to have angiographically-documented but clinically asymptomatic CAD (14). Both studies found that ED symptoms preceded CAD by a significant time period. PNU-120596 In the Vlachopoulos study onset of symptomatic ED occurred 25 months before the breakthrough of silent CAD (14). Montorsi’s topics experienced ED symptoms typically 39 months before the onset of CAD symptoms (13). Research such as for example these support the final outcome that sufferers with PNU-120596 ED could be suffering from a far more significant systemic procedure which ED could be a good predictor of CVD. The chance of most CV occasions myocardial infarction cerebrovascular occasions and all-cause mortality had been elevated in guys with ED in a number of meta-analyses (15 16 These research support the hypothesis that ED is normally a silent marker for CVD. Ponholzer computed the 10-calendar year threat of developing CVD in guys with ED using the Framingham Risk Rating (FRS) and reported that guys with moderate to serious ED PNU-120596 acquired a 43% and 65% elevated comparative risk for developing cardiovascular system disease or heart stroke respectively (17). One research evaluated ED’s function in disease prediction beyond the FRS. This year 2010 Araujo additional evaluated data in the MMAS and discovered that ED was certainly associated with an increased occurrence of CAD but it didn’t predict who develop upcoming CAD Rabbit Polyclonal to MRC1. much better than set up risk factors as well as the FRS (18). Unlike this the Princeton III Consensus Meeting recommended that ED itself can be an unbiased marker of elevated risk for CVD CAD heart stroke and all-cause mortality. This consensus -panel considered a guy with organic ED to become at elevated CVD risk until additional evaluation suggested usually and provided help with CV risk testing and stratification (19). A common pathophysiology for ED and CVD To raised understand the hyperlink between PNU-120596 ED and CVD a knowledge from the physiology of erection pays to. Erection outcomes from coordinated conversation of hormonal vascular and neural systems aswell seeing that psychological inputs. Sensory insight from receptors in your skin glans urethra and corporat cavernosa travel via the dorsal nerve from the male organ and afterwards the pudendal nerve to S2-S4 nerve root base. Interaction using the thalamus and sensory cortex network marketing leads to.
Background Pancreatic tumor includes a five-year success price of ~8% with feature molecular heterogeneity and restricted treatment plans. (mtDNA) and nuclear genes encoding mitochondrial elements and metabolic genes. Phenotypic characterization of PDCLs included dimension of cellular air consumption price (OCR) and extracellular acidification price (ECAR) utilizing a Seahorse XF extracellular flux analyser targeted metabolomics and pathway profiling and radiolabelled glutamine tracing. Outcomes We discovered 24 somatic mutations in XL-888 the mtDNA of 12 patient-derived pancreatic cancers cell lines (PDCLs). An additional 18 mutations had been identified within a targeted research of ~1000 nuclear genes very important to mitochondrial function and fat burning capacity. Comparison with guide datasets indicated a solid selection bias for non-synonymous mutants with forecasted functional results. Phenotypic analysis demonstrated metabolic changes in keeping with mitochondrial dysfunction including decreased oxygen intake and elevated glycolysis. Metabolomics and radiolabeled substrate tracing indicated the initiation of reductive glutamine rate of metabolism and lipid synthesis in tumours. Conclusions The heterogeneous genomic scenery of pancreatic tumours may converge on a common metabolic phenotype with individual tumours adapting to improved anabolic demands via different genetic mechanisms. Focusing on producing metabolic phenotypes may be a effective restorative strategy. Electronic XL-888 supplementary material The online version of this article (doi:10.1186/s40170-017-0164-1) contains supplementary material XL-888 which is available to authorized users. (ETC complex III) (Table?1). This effect is entirely consistent with disrupted CytB activity in these cells which would be expected to impede the conversion of succinate to fumarate. Mullen et al.  have previously observed high levels of succinate in cells with ETC complex III mutations using reductive carboxylation. The flux of metabolites through their respective pathways is key in understanding the part they perform in malignancy metabolism and the overall metabolic needs of the malignancy cell. To forecast which metabolic pathways were dysregulated in pancreatic tumour cells we performed Pathway Activity Profiling (PAPi) analysis of metabolomics data . Pathway activity scores calculated using this method have been shown XL-888 to be an accurate predictor for metabolic flux  even though there may be redundancy between metabolites with some Rabbit polyclonal to KLF4. becoming key in several pathways. Activity scores were compared between different cell lines and different growth media conditions and created the input for hierarchical clustering (Fig.?4). ANOVA was used to determine pathways with significantly different activity (copy number has also been shown to result in metabolic reprogramming in vivo inside a mouse model of lung malignancy with increased channelling of glucose-derived metabolites into the TCA cycle and glutathione biosynthesis . Understanding the mechanistic basis of these metabolic alterations and their part in tumourigenesis is the focus of intense interest. [6 11 Focusing on rate of metabolism as an effector of oncogenic transmission transduction pathways required for cell growth may be an effective way of treating cancers that are driven by genetic alterations that are not tractable as direct drug focuses on [11 19 Of direct interest to pancreatic cancers which have very high penetrance of KRAS mutations focusing on metabolic enzymes offers been shown to be effective in treatment of KRAS mutant tumours in pre-clinical models of lung malignancy . Mitochondria are the main site for energy generation within cells and are controlled by interplay between the nuclear and mitochondrial genomes. The mitochondrial genome (mtDNA) encodes 37 genes including 13 subunits of the mitochondrial electron transport chain (ETC). Mitochondrial dysfunction and/or mutations in mitochondrial genes may play a role in shifting cellular metabolism to a state more favourable for tumour proliferation [20 21 Build up of somatic mtDNA mutations has been observed in numerous tumour types [26 27 and a limited number of studies have shown a direct part for specific mtDNA mutations in tumourigenesis using.
History The mechanisms that maintain sterility in the urinary tract are incompletely understood. localized HD5 to the urothelium of the bladder and ureter. In the kidney HD5 was primarily produced in the distal nephron and collecting tubules. Using immunoblot and ELISA assays HD5 was not routinely detected in noninfected human urine samples while mean urinary HD5 production increased with urinary tract infection. Conclusions/Significance is usually expressed throughout the urinary tract in noninfected subjects. Specifically HD5 is usually expressed throughout the urothelium of the lower urinary tract and in the collecting tubules of the kidney. With contamination HD5 expression increases in the kidney and levels become detectable in the urine. To our knowledge our findings represent the first to quantitate HD5 expression and production in the human kidney. Moreover this is the first report to detect the presence of HD5 in infected urine samples. Our results suggest that HD5 may have an important role in maintaining urinary tract sterility. Launch The urinary system in addition to the urethral meatus is SB 525334 sterile despite its closeness with fecal flora generally. The precise systems where the urinary system keeps its sterility aren’t well grasped. Proposed mechanisms adding to defense from the urinary tract consist of urine flow modifications in urine pH and osmolarity regular bladder emptying chemical-defense the different parts of the uroepithelium and epithelial losing/influx of effector immune system cells with bacterial excitement . Furthermore antimicrobial peptides (AMPs) possess recently been proven to have a significant role in preserving urinary system sterility . AMPs which serve as organic antibiotics made by nearly all microorganisms certainly are a ubiquitous element of the innate immune system. AMPs are cationic molecules expressed by phagocytic white cells and epithelial cells. In humans and other mammals defensins certainly are a main category of AMPs. Defensins routinely have broad-spectrum antimicrobial activity against gram-positive and gram-negative bacterias infections fungi and protozoa  . Defensins are originally synthesized as preproproteins and go through processing to be mature biologically energetic peptides . In human beings defensins are categorized into 1 of 2 families based on their disulfide bridging design – the alpha-defensins or the beta-defensins . In the urinary system the beta-defensins SB 525334 are expressed through the entire uroepithelium. Epithelial cells coating the kidney’s loop of Henle distal tubule and collecting duct constitutively exhibit individual beta-defensin 1 (hBD1). Although urinary degrees of hBD1 are inadequate to eliminate invading bacterias hBD1 offers a fast-acting antimicrobial covering of tubular lumens and prevents illness by inhibiting bacterial attachment to the urothelium . Recent studies indicate the redox-state of hBD1 significantly affects antimicrobial potency such that the reduced peptide is much SB 525334 more potent the disulfide-linked oxidized form . The significance SB 525334 of this in the urothelial surface has not been identified. Another defensin human being beta-defensin 2 (hBD2) is not constitutively indicated in healthy kidney tissue; however hBD2 manifestation is definitely induced by illness . Unlike the beta-defensins the part of epithelial-derived alpha-defensins is not well explained in the urinary system. The appearance and function of alpha-defensin HD5 and HD6 possess mainly been reported in the tiny intestine where these are secreted by Paneth cells in to the intestinal crypts and donate to the total amount of intestinal microbiotica . HD5 in addition Mouse monoclonal to CD48.COB48 reacts with blast-1, a 45 kDa GPI linked cell surface molecule. CD48 is expressed on peripheral blood lymphocytes, monocytes, or macrophages, but not on granulocytes and platelets nor on non-hematopoietic cells. CD48 binds to CD2 and plays a role as an accessory molecule in g/d T cell recognition and a/b T cell antigen recognition. has been localized in the male and woman genital tracts with evidence suggesting SB 525334 that it is inducible and important in eradicating illness   . Urinary HD5 has been detected in individuals who have undergone ileal neobladder reconstruction and ileal conduit urinary diversion whereby the source of HD5 production was primarily credited to the ileal Paneth cells  . HD5 offers antibacterial activity against common uropathogenic gram-positive bacteria and gram-negative bacteria . SB 525334 HD5 also has antimicrobial activity against uropathogenic viruses like adenovirus and BK disease   . In this study we provide the initial description and quantification of HD5 manifestation in the human being kidney and further define its manifestation in the lower.
Objective The objectives of this study was to clarify the relationship between kyphosis and Gastroesophageal reflux disease (GERD) by evaluation of spinal alignment obesity osteoporosis back muscle strength intake of oral drugs and smoking and alcohol history in screening of a community population to determine the factors related to GERD symptoms. of GERD but the relationship between kyphosis and GERD is unclear. Subjects and methods We examined 245 subjects (100 Ridaforolimus males and 145 females; average age 66.7?years old) in a health checkup that included evaluation of sagittal balance and spinal mobility with SpinalMouse? GERD symptoms using the Frequency Scale for Symptoms of GERD (FSSG) questionnaire body mass index osteoporosis back muscle strength number of oral drugs taken per day intake of nonsteroidal anti-inflammatory drugs (NSAIDs) intake of bisphosphonates and smoking and alcohol intake. Results Multivariate logistic regression analysis including all the variables showed that lumbar lordosis angle sagittal balance number of dental drugs taken each day and back again muscle strength got significant results on the current presence of GERD (OR 1.1 1.11 1.09 and 1.03; 95%CI 1.03 1.02 1.01 and 1.01-1.04; ensure that you Chi-square check was used to judge differences between your GERD(+) and GERD(?) organizations. Univariate and multivariate logistic regression analyses had been performed to judge the odds percentage (OR) with 95% self-confidence period (95%CI) for potential risk elements for GERD. Possibility values of significantly less than 0.05 were considered to be significant statistically. Outcomes The mean ideals of measured factors in the topics are detailed in Desk?1 and correlations between FSSG ratings and additional variables are Ridaforolimus shown in Desk?2. The FSSG score was correlated with the lumbar lordosis angle and back again muscle tissue strength negatively; and favorably correlated with the T/L percentage and the amount of dental drugs taken each day (Desk?2). The 245 individuals had been categorized into two organizations predicated on GERD symptoms with 60 (24.5%) in the GERD(+) group (Desk?3). The lumbar lordosis angle Ridaforolimus back again muscle power and sacral inclination angle had been Ridaforolimus significantly smaller as well as the Vwf T/L percentage and the amount of dental drugs taken each day had been significantly bigger in the GERD(+) group set alongside the particular ideals in the GERD(?) group. Gender age group BMI osteoporosis thoracic kyphosis position spinal ROM intake of oral NSAIDs oral bisphosphonates and smoking and alcohol history did not differ significantly between the GERD(+) and GERD(?) groups (Table?3). Univariate and multivariate logistic regression analyses were performed to evaluate the OR for risk factors for GERD. In univariate analysis the number of oral drugs taken per day lumbar lordosis position back again muscle power T/L percentage and sacral inclination position had been significantly from the existence of GERD (Desk?4). In multivariate logistic regression evaluation including all of the factors lumbar lordosis position T/L percentage amount of dental drugs taken each day and back again muscle strength got a substantial association with the current presence of GERD (OR 1.1 1.11 1.09 and 1.03; 95%CI 1.03 1.02 1.01 and 1.01-1.04; p?=?0.003 0.015 0.031 and 0.038 respectively) (Desk?5). These outcomes show a reduction in the lumbar lordosis position poor sagittal stability an increased amount of dental drugs each day and reduced back again muscle strength are essential risk elements for GERD. Desk?1 Clinical background from the subjects Table?2 Correlation between total FSSG score and other variables Table?3 Difference in variables between subjects with and without GERD Table?4 Results of univariate logistic regression analysis: odds ratio (OR) with 95% confidence interval (95% CI) for the risk of GERD Table?5 Results of multivariate logistic regression analysis: odds ratios (OR) with 95% confidence interval (95% CI) for the risk of GERD Discussion Regurgitation of gastric contents into the esophagus is prevented by the lower esophageal sphincter (LES). GERD is induced by decreased LES pressure and this may be caused by esophageal hiatal hernia which affects the function of the anti-reflux barrier at the gastroesophageal junction [26 27 The prevalence of hiatal hernia increases in elderly female patients  and the presence of hiatal hernia has been correlated with the incidence of GERD [28 29 This partly accounts for the increased prevalence of GERD with the aging of culture. Osteoporosis and kyphosis are also suggested to donate to the improved prevalence of GERD and hiatal hernia [12 13 Yamaguchi et al. discovered that the existence and amount of vertebral fractures had been significantly connected with hiatal hernia in 87 postmenopausal ladies  and Kusano et al. demonstrated that how big is hiatal.
Horm (2012) Environment: a potential source of animal and individual an infection with influenza A (H5N1) trojan. between Apr 2007 and Feb 2010 gathered following outbreaks of avian influenza in Cambodia. The methods utilized to concentrate H5N1 trojan from water examples were structured either on agglutination from the trojan with chicken crimson bloodstream cells or on adsorption on cup wool accompanied by an elution‐focus stage. An elution‐focus method was employed for dirt specimens. All examples that examined positive by true‐period RT‐PCRs (qRT‐PCRs) concentrating on the HA5 M and NA1 genes were inoculated into embryonated hen eggs for computer virus isolation. Results? Of a complete of 246 examples 46 (19%) examined positive for H5N1 by qRT‐PCRs. Viral RNA was PIK-93 often detected in dirt dirt and soil examples in the farms’ environment (respectively 46 31 and 15%). Examples gathered PIK-93 from ponds provided a lower percentage of positive examples (6%) when compared with those collected in the farms (24%). In mere one particular test infectious trojan contaminants were isolated successfully. Bottom line? During H5N1 trojan outbreaks many environmental samples encircling outbreak areas are polluted by the trojan and may become potential resources for individual and/or animal contaminants. Keywords: Cambodia environment H5N1 trojan influenza outbreaks transmitting risk Introduction Chicken contaminated with avian influenza infections (AIV) generally shed many viral particles within their faeces saliva and sinus release 1 PIK-93 2 that may result in the contaminants of environmental elements such as drinking water pond sediment dirt and earth as shown in a variety of experimental 3 4 5 and field research. 6 7 8 Previous research concentrating on live parrot markets also demonstrated that many AIV subtypes could possibly be isolated from environmental swabs gathered within such marketplaces. 9 10 In a single research disease isolation was made at actually higher rates in poultry drinking water than in bird droppings randomly collected in the markets. 11 The H5N1 highly pathogenic avian influenza (HPAI) disease is a major public health concern in Southeast Asia where it has widely spread since its first detection in 1997. 12 Despite numerous prophylactic processes carried out in several countries including poultry vaccination campaigns the disease has become enzootic in the region. In Cambodia since the 1st detection of the HPAI H5N1 disease in 2004 18 human being instances of illness (16 fatalities) MAD-3 and almost 30 outbreaks in poultry have been reported as of October 10th and 24th 2011 respectively. 13 14 The H5N1 disease has the ability to persist in different types of water 15 16 and H5N1 viral RNA was previously recognized in environmental specimens such PIK-93 as mud pond drinking water aquatic plant life and earth/dirt swabs 17 18 19 including within the environment of H5N1 outbreaks areas in Cambodia. 8 Within this nation individual situations of H5N1 HPAI happened mainly after immediate contact with contaminated chicken 20 although seroepidemiological research discovered bathing and going swimming in ponds as various other major risk elements for individual contaminants. 21 22 That is in keeping with data reported from neighbouring countries which also claim that contact with H5N1‐contaminated conditions (soiled water chicken‐slaughtering services faeces‐structured fertilizer litter) without immediate contact with contaminated poultry is PIK-93 connected with an increased threat of individual an infection. 23 24 25 26 27 The precise role of the surroundings in the transmitting of H5N1 trojan remains poorly known. Few authors have got described the success of H5N1 trojan in water earth or various areas in lab‐controlled circumstances with temperatures generally which range from 0 to 25°C 15 16 28 29 but hardly any is known concerning the persistence from the disease in natural configurations where outbreaks frequently occur for instance in exotic countries where typical temps can reach over 35°C in the color. The goal of this research was PIK-93 to research various environmental parts as potential reservoirs for H5N1 virus and thus as potential sources for human and animal contamination. Materials and methods Sample collection In response to the notification of confirmed cases of H5N1 infection in humans or poultry we conducted four investigations in the households of the index cases and in the surrounding vicinities. Environmental specimens were collected in five households of three Cambodian provinces between April 2007 and February 2010 (Figure?1). These.
Background Survival is increasing after early breast malignancy revealing frequent relapses and possibility of developing secondary malignancies. therapy and hormonal therapy by tamoxifen. After completion of 5 PIK3C2G years of tamoxifen our patient reported asthenia; a physical examination found hepatomegaly massive splenomegaly measuring 21 cm and supraclavicular lymphadenopathy. The staging showed lung and liver metastases. Morphology and immunohistochemical profile of this metastasis identified an adenocarcinoma of mammary origin. In parallel the diagnosis of chronic myeloid leukemia was suspected because of the presence of a leukocytosis at 355 × 109/L with circulating blasts of 4%. Chronic myeloid leukemia was confirmed by a bone marrow biopsy with the presence of Ph chromosome on cytogenetical analysis. Daily imatinib was ordered concurrently with chemotherapy-type docetaxel. The metastases were stable after nine courses of chemotherapy. Due to breast cancer progression 4 months later bevacizumab and capecitabine were introduced. A major molecular response was achieved after 12 and 18 months. She has now completed 2 years of follow-up still on a major molecular response and is undergoing imatinib and capecitabine treatment. Conclusions Leukocytosis in breast cancer patients can reveal chronic Barasertib myeloid leukemia. It may warrant a workup Barasertib to find the underlying etiology which could include a secondary hematological malignancy. Keywords: Relapse Breast cancer Chronic myeloid leukemia Management Background Breast cancer is the most frequently diagnosed cancer among women . Due to early detection of breast cancer and effective therapeutic regimens survival is usually increasing but it is associated with frequent relapses and the possibility of developing secondary malignancies . The concomitant occurrence of these two events is usually exceptionally disastrous and lethal in this population. Though a rare occurrence it is possible Barasertib to see secondary leukemias in breast cancer survivors. Data around the risks of chronic myelogenous in breast cancers survivors after adjuvant therapy are sparse. We report a case of a Moroccan woman who presented with recurrent breast cancer concurrently diagnosed with chronic myelogenous leukemia (CML). Case presentation A 42-year-old Moroccan woman was diagnosed with breast cancer in 2008 and underwent right modified radical mastectomy. The tumor was infiltrating ductal carcinoma pT2N1M0 with 2 out of 12 lymph nodes Barasertib positive. The tumor expressed hormone receptors (estrogen receptor was 90% and progesterone receptor was 70%) and the HercepTest result was unfavorable. Her complete blood count showed a hemoglobin level of 13.7 g/dL (normal range: 12-16 g/dL) a platelet count of 250 × 109/L (normal range: 150-400 × 109/L) a leukocytes count of 7.3 × 109/L (normal range: 4-10 × 109/L) and a neutrophils count of 5.1 × 109/L (normal range: 1.5-7 × 109/L). She received six cycles of adjuvant 5-fluorouracil (500 mg/m2) epirubicin (100 mg/m2) and cyclophosphamide (500 mg/m2) (FEC100). The total dose was 960 mg of epirubicin and 4800 mg of cyclophosphamide. Adjuvant chemotherapy was followed by radiation therapy to her chest wall and ipsilateral axillary lymph node metastasis. She was placed on tamoxifen for 5 years. After completion of 5 years of tamoxifen our patient reported asthenia; a physical examination found hepatomegaly splenomegaly extending into the umbilicus measuring 21 cm and supraclavicular lymphadenopathy measuring 2 cm painless and mobile. Her cancer antigen 15-3 (CA15-3) level was 80 UI/mL (normal value less than 25 UI/mL). A thoracoabdominal computed tomography scan showed lung metastases with a hypodense nodule in segment VII of the liver characterized as a metastasis on a magnetic resonance imaging (MRI) scan (Fig.?1). A biopsy of this nodule was performed. Morphology and an immunohistochemical profile of this metastasis reveal an adenocarcinoma of mammary origin expressing cytokeratin 7 and mammaglobin (Fig.?2). The tumor was triple unfavorable (TN). Fig. 1 An abdominal magnetic resonance imaging scan showing a nodule in liver segment VII hypointense on T1 measuring 37 mm × 32 mm Fig. 2 Moderately differentiated adenocarcinomatous proliferation: a: hematoxylin and eosin staining ×400 Barasertib b Intense expression of mammaglobin by tumor cells Concurrently our patient’s blood count showed a hyperleukocytosis at 355 × 109/L with a neutrophil count of 152 × 109/L her hemoglobin level was 10.6 g/dL.
Hepatitis B pathogen (HBV) produces large levels of subviral surface area antigen contaminants (HBsAg) which circulate in the bloodstream outnumbering virions around 1\103-6 times. had been isolated from sera of 11 HBsAg companies by selective immunoprecipitation with monoclonal anti-HBs-IgG total RNA was extracted and human being miRNAs had been screened by TaqMan real-time quantitative PCR Arrays. Thirty-nine human being miRNAs had been found to become significantly from the immunoprecipitated HBsAg as dependant on both comparative DDCT evaluation and nonparametric testing (Mann-Whitney p<0.05) regarding controls. Furthermore immunoprecipitated HBsAg contaminants contained Ago2 proteins BRL-15572 that may be exposed in ELISA just after 0.5% NP40. HBsAg connected miRNAs had been liver-specific (most typical?=?miR-27a miR-30b miR-122 miR-126 and miR-145) aswell as immune system regulatory (most frequent?=?miR-106b and miR-223). Computationally predicted target genes of HBsAg-associated miRNAs highlighted molecular pathways dealing with host-pathogen The finding that HBsAg particles Rabbit polyclonal to SelectinE. carry selective pools of hepatocellular miRNAs opens new avenues of research to disentangle the complex interactions between host and HBV and provides a non invasive tool to study the physiopathology of liver epigenetics. Introduction Hepatitis B virus (HBV) is a non-cytopathic hepatotropic virus with complex interactions using the host’s immune system -. HBV engages the cellular machinery of infected hepatocytes for the assembly and release of double-shelled 42 nm complete virions and 20 nm subviral particles . HBV produces extremely high quantities of hepatitis B surface antigen (HBsAg) the coating structure of both virions and defective particles which outnumber virions 103-106 occasions . Moreover in individuals coinfected with the defective hepatitis delta computer virus (HDV) the small HDV-RNA genomes borrow subviral HBsAg particles as outer coats to form the 36 nm circulating HDV virions -. Upon replication mediated by human RNA polymerase II (Pol II) HDV-RNA is usually released from hepacytes together with delta antigen (HDAg) as ribonucleoprotein complex (RNP) within the HBsAg envelope. The same human Pol II is usually involved into the synthetic pathway of microRNAs (miRNAs) a class of important regulatory elements of cellular epigenetics which are incorporated into specific RNP RNA-induced silencing complex (RISC) . MiRNAs have been increasingly implicated also into intercellular communications as they were detected in serum either as free circulating RNA-induced silencing complexes (RISC) or in association with cell-derived particulate forms BRL-15572 including exosomes and microvescicles -. Such a similarity of the RNP-related biological pathways in both HBV/HDV system and host cells prompted us to research whether HBsAg contaminants could provide casing to hepatocellular miRNAs because of their discharge from HBV contaminated cells and blood flow into the bloodstream. In this research we record the isolation from the circulating HBsAg small fraction from sera of 11 HBV companies for full individual miRNA profiling by real-time quantitative PCR. Particular repertoires of hepatocellular miRNAs were discovered to become connected with immunoprecipitated HBsAg significantly. Materials and Strategies Isolation of circulating HBsAg contaminants HBsAg contaminants had been immunoprecipitated with anti-HBs-IgG from 11 sera of HBsAg companies (stage of HBV infections and disease was categorized as previously reported  and 2 HBsAg harmful handles) whose features are referred to in Desk 1. Sera had been pre-cleared by incubation with BRL-15572 sepharose-protein G slurry (GE Health care UK; 120 min at area temperature) retrieved by centrifugation and incubated immediately at 4°C with preformed sepharose-protein G-IgG complex for either a) HBsAg immunoprecipitation (where IgG?=?mouse monoclonal anti-HBs antibody Santa-Cruz Biotechnologies clone 1023) or b) control immunoprecipitation (where IgG?=?mouse monoclonal anti-human c-myc antibody Invitrogen clone 9E10.3) (Physique 1). After centrifugation we obtained leftover sera or flowthroughs and immunoprecipitated fractions for BRL-15572 both HBsAg positive (n?=?11) and HBsAg negative (n?=?2) samples. In parallel a control immunoprecipitation was performed on precleared.
The promyelocytic leukemia protein (PML) is the main organizer of stress-responsive subnuclear structures called PML nuclear bodies. activity of the toxin listeriolysin O (LLO). These events trigger an antibacterial response that is not observed during infection by an LLO-defective mutant but which can be phenocopied by specific induction of PML de-SUMOylation. Using transcriptomic and proteomic microarrays we also characterized a network of immunity genes and cytokines which are controlled by PML in response to disease but independently through the listeriolysin O toxin. Our research thus shows two mechanistically specific complementary jobs of PML in sponsor responses against infection. IMPORTANCE The promyelocytic leukemia proteins (PML) can be a eukaryotic proteins that may polymerize in discrete nuclear assemblies referred to as PML nuclear physiques (NBs) and takes on essential roles in lots of different cellular procedures. Essential to its function PML could be modified by SUMO a ubiquitin-like modifier posttranslationally. Identification from the part of PML in antiviral defenses continues to be deeply documented. On the other hand the part of PML in antibacterial defenses continues to be elusive. Right here we determine two mechanistically specific complementary jobs of PML in antibacterial reactions against pathogens such as for example and retinoic acidity receptor alpha genes in severe promyelocytic leukemia (APL) individuals AZ-960 (1 -5). In regular cells PML exists both like a diffuse type in the nucleoplasm and cytoplasm and polymerized in discrete subnuclear constructions referred to as PML nuclear physiques (NBs). PML protein define the limitations of the NBs which constitute non-membrane-bound compartments in the nucleoplasm (6 -8). PML NBs are powerful stress-responsive constructions that constitutively or transiently AZ-960 be capable of recruit a lot of proteins. Research investigating the foundation for arsenic trioxide-initiated APL get rid of have recommended that oxidative tension promotes PML multimerization and PML NB development (6 7 9 -12). PML NBs could also regulate the posttranslational adjustments of recruited proteins therefore managing their sequestration activation or balance (11 -13). In contract with its huge and varied repertoire of interacting companions PML is involved with many different mobile processes such as for example senescence apoptosis or antiviral AZ-960 protection (6 7 14 -17). The part of PML in antiviral protection can be illustrated by the bigger level of sensitivity of PML knockout mice to different infections (evaluated in research 16). Many infections counteract this PML antiviral activity by reducing PML manifestation or stability or by altering PML NB integrity (16 17 is a Gram-positive bacterium that is responsible for the foodborne disease listeriosis. Although well adapted to survive extracellularly this pathogen can also infect survive and replicate in the cytoplasm of both macrophages and nonprofessional phagocytic cells such as epithelial cells (18). The numerous strategies employed by to interfere with host processes have raised this bacterium as one of the best model organisms for the study of bacterial pathogenesis and pathophysiology. Among the different Rabbit Polyclonal to SMUG1. cellular pathways subverted by SUMOylations. De-SUMOylation reactions catalyzed by the different SUMO isopeptidases of the host cell then result in a rapid loss of SUMO conjugates. Several nuclear factors including transcription factors are de-SUMOylated in response to infection explaining how host SUMOylome alteration during infection leads to host transcription modifications (21). Interestingly other bacterial pathogens were shown to manipulate host SUMOylation machinery during infection. Infection of HeLa cells with infection (23). In addition SUMOylation was reported to restrain production of inflammatory cytokines by silencing expression (24). Alteration of SUMOylation may thus contribute to the AZ-960 inflammatory response associated with serovar Typhimurium a bacterium responsible for gastroenteritis in humans was also shown to decrease the Ubc9 level during infection and to alter the host SUMOylome during infection (25). Together these studies unveiled the role of SUMOylation in the regulation of key host factors controlling infection by different classes of pathogens. Interestingly SUMOylation plays a critical role in the function of PML and PML NBs. PML can indeed be SUMOylated on several lysine residues and.

domain: literature


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Although in-person Pride marches originally planned for this summer are now postponed or re-envisioned online due to the pandemic, there are lots of alternative ways to support the movement. This week, we are highlighting two titles for your LGBTQ+ and ally reading lists.
Crisis by Karin Boye
Karin Boye’s Crisis is a queer modernist masterpiece. Recently published in a translation by Amanda Doxtater, it defies stylistic conventions through its innovative use of voice and has even had a love letter written to it! You can find an extract here, and order the full book while supporting your friendly local bookshop via Hive here.
Bang: A Novel about the Danish Writer by Dorrit Willumsen
Bang by Dorrit Willumsen, translated by Marina Allemano and a Nordic Council Literature Prize awardee, re-works the life story of the pioneering journalist, author and dramatist Herman Bang in a series of compelling flashbacks that unfold during his last fateful reading tour across the USA. Bang (1857–1912) was a key figure in Scandinavia’s Modern Breakthrough. Having fled his birthplace on the island of Als ahead of the Prussian advance of 1864, he was later hounded out of Copenhagen, Berlin, Vienna, and Prague by homophobic laws and hostility to his uncompromising social critique. You can read an extract from the first chapter detailing Bang’s memories of his childhood here or order the book through Hive here.
Norvik Press brought one of Denmark’s greatest writers, Dorrit Willumsen, author of the novel Bang, over the North Sea for a chat with her translator, Professor Marina Allemano, about their love of the nineteenth-century author Herman Bang, and walking over cracks in the ground. The event took place high above the ground on the tenth floor in the Arena Centre in Bloomsbury. With an amazing view of the London skyline, the city itself made a poetic backdrop to the literary conversation.
The idea of the book originated when Willumsen was asked to write about one of her heroes. She had two subjects in mind, one being her grandfather, and the other Herman Bang – her favourite Danish writer. Known for re-imagining historical figures using the first person, Willumsen used the same technique for the protagonist in Bang. The work was originally commissioned by her publisher as a biography. Willumsen, however, discovered this was problematic, as there were so many biographies about Bang already in print. She read them all, and as she progressed in her research, it became increasingly difficult for her to hold her creativeness at bay. Eventually, the book turned out to be a novel about the last days of the eccentric, flamboyant writer and inspiring actor. The story unfolds through a series of flashbacks as we follow Bang on his final book tour through America. He is ill, dependent on help from others and on his morphine to get to sleep. But the reader also gets to know the younger, livelier man through his reminiscing.
A household name in Denmark, Dorrit Willumsen started out as a writer in 1965, although sadly not much of her work is translated into English. This translation of Bang goes some way towards remedying that. And that task was undertaken by Allemano, who has always had a great admiration for Willumsen and published a biography about her in Danish in 2015. When asked where she positions herself as a translator, Allemano humbly defined herself as a servant to the original work, a technician; a problem solver. She described the translating process with an analogy: imagine walking on an Earth full of cracks. When you look down between the cracks, you can vaguely distinguish the real, more beautiful world underneath, but you can never fully get to it. However, this modest depiction of her own efforts was quickly modified by voices in the audience. Translation is also a rewriting of the script and demands a great deal of artistic imagination.
Throughout the evening Willumsen lapsed into several entertaining anecdotes of the writing process and how Bang lived his life. The audience learnt that he was a man with a love of spending money when he had it and reduced to borrowing when he did not. He even went so far as borrowing from his doctor and then from his doctor’s wife, with a plea that she would not tell her husband … Willumsen also described what it was like working on a project like Bang, saying it took her five years to write the book; when she had finally finished, her son was relieved that Bang had moved out after living in their home for so long.
Rounding off the evening, as the darkness had settled – creating the perfect storytelling ambience – Dorrit and Marina delighted the audience with the opening passage of Bang in both Danish and English. Herman Bang’s brusque meeting with the big city of New York made a stark contrast to the romantic twinkling of the skyline in the background.
We’ve come to that time of the year where the only sensible thing to do is to snuggle up under a blanket in the biggest, comfiest chair you can find, and get yourself something hot to drink and a good book. Well, we don’t do blankets, but we can help with the book part! At Norvik, we’ve put together a seasonal recommended reading list of our treasures fit for winter. These are perfect as stocking fillers for friends and family, or why not treat yourself for a few hours in that comfy chair during what the Swedes call mellandagarna (the days between Christmas and New Year)? Click on the link in each title below to visit our website for more information on the books, and how to buy.
This spirited and at times sinister novel ensnares the reader in a tangled encounter between modern-day Scandinavia and the ancient world of myth. In the 1980s, a hardworking Icelandic businesswoman and her teenage daughter Dís, who has been arrested for apparently committing a strange and senseless robbery, are unwittingly drawn into a ritual-bound world of goddesses, sacrificial priests, golden thrones and kings-in-waiting. It is said that Gunnlöth was seduced by Odin so he could win the ‘mead’ of poetry from her, but is that really true, and why was Dís summoned to their world?
Wilfred – alias Little Lord – is a privileged young man growing up in upper-class society in Kristiania (now Oslo) during the halcyon days before the First World War. Beneath the strikingly well-adjusted surface, however, runs a darker current; he is haunted by the sudden death of his father and driven to escape the stifling care of his mother for risky adventures in Kristiania’s criminal underworld. The two sides of his personality must be kept separate, but the strain of living a double life threatens breakdown and catastrophe. This best-selling novel by Johan Borgen, one of Norway’s most talented twentieth-century writers, is also an evocative study of a vanished age of biplanes, variety shows, and Viennese psychiatry.
29 January 1912. In a train compartment in Ogden, Utah, a Danish author was found unconscious. The 54-year-old Herman Bang was en route from New York to San Francisco as part of a round-the-world reading tour. It was a poignant end for a man whose life had been spent on the move. Having fled his birthplace on the island of Als ahead of the Prussian advance of 1864, he was later hounded out of Copenhagen, Berlin, Vienna and Prague by homophobic laws and hostility to his uncompromising social critique as journalist, novelist, actor and dramaturge. Dorrit Willumsen re-works Bang’s life story in a series of compelling flashbacks that unfold during his last fateful train ride across the USA. Along the way, we are transported to an audience in St Petersburg with the Dowager Empress Maria Feodorovna, to a lovers’ nest in a flea-ridden Prague boarding house, to the newsrooms and variety theatres of fin-de-siècle Copenhagen, and to a Norwegian mountainside, where Claude Monet has come to paint snow and lauds Bang’s writing as literary impressionism.
A richly-illustrated one-volume hardback edition of Selma Lagerlöf’s classic tale. This novel started out as a commissioned school reader designed to present the geography of Sweden to nine-year-olds, but Lagerlöf’s work quickly won international fame and popularity, which it still enjoys over a century later. It is a fantastic story of a naughty boy who climbs on the back of a gander and is then carried the length of the country, learning both geography and good behaviour as he goes. It is a story of Sweden, where every province has its tale and out of the many fantasies, a diverse country emerges; a country of the great and the grand, majestic nature and lords and ladies, but also a country of farmers and fishers, goose-herds and Sami, miners and loggers, and of animals – rats and eagles and elk, foxes and geese and all the other creatures who are part of the life cycle of the land.
A House in Norway tells the story of Alma, a divorced textile artist who makes a living from weaving standards for trade unions and marching bands. She lives alone in an old villa, and rents out an apartment in her house to supplement her income. She is overjoyed to be given a more creative assignment, to design a tapestry for an exhibition to celebrate the centenary of women’s suffrage in Norway, but soon finds that it is a much more daunting task than she had anticipated. Meanwhile, a Polish family moves into her apartment, and their activities become a challenge to her unconscious assumptions and her self-image as a good feminist and an open-minded liberal. Is it possible to reconcile the desire to be tolerant and altruistic with the imperative need for creative and personal space?
Kerstin Ekman’s wonderful poem Childhood is presented here as a dual language English/Swedish publication illustrated with original photographs provided by the author. Kerstin Ekman is primarily known as a novelist, but she has occasionally turned to free verse, especially when the subject is autobiographical. In 1993-1994, Swedish TV 1 conducted a series of talks with prominent writers under the rubric ‘Seven Boys and Seven Girls’. In place of an ordinary interview, Kerstin Ekman read aloud Barndom (Childhood). The prose passages are quotations from Ekman’s 1988 novel Rövarna i Skuleskogen (The Forest of Hours).
Also by Kerstin Ekman is the novel The Angel House, in which Ekman provides an alternative, subversive history of the community in which she grew up. It is a story that stretches through a century, told through the perspective of the generation of women living in those times:
A giant had a washbowl which he set down in the forest at the base of a moraine. It was made of granite and deeply indented, and he filled it with clear, amber water which looked like solidified resin when the sun shone on it on a summer’s afternoon.
In winter, the top layer of the water froze into a lid and the entire bowl went very still, just like the forest around it. Then, down at its deepest point, a pattern of stripes and dashes would move. A pike, if there had been one, would have seen that it was not broken lengths of hollow reed swaying there but thousands of his brothers the perch, sluggishly and cautiously changing positions.
Across the top of the lid spun a rope-covered ball and after it, heavy but fast, skated men with clubs in their hands. They were dressed in black knee breeches and grey woollen sweaters. About half of them had black, peaked caps with both earflaps turned up and kept in place with two thin shoelaces knotted on top of their heads.
Half had red knitted hats with tassels. Sometimes one of the ones in peaked caps went whizzing off with long blade strokes, feet inclining inwards, guiding the ball in front of him with his club. If a tassel-hat got in his way, both of them would go crashing onto the rough ice near the shore, flattening the broken reeds and sending ice and coarse snow spraying round their metal blades.
Round the edge of the Giant’s Washbowl, people stood watching, virtually all men, coming so far out of town. But Ingrid Eriksson was standing there too. She stood there every winter Sunday, whenever there was a match on.
For further reading in the New Year, watch out for the brilliant Pobeda, coming very soon.
Finally, we’d like to wish all our readers a very Happy Christmas!
The celebrations of Kirsten Thorup and this year’s Nordic Council Literature Prize are still not over, and in the light of this, we would like to announce that another winner of this prestigious award is joining our ranks. Our latest novel, fresh from the press, is by Dorrit Willumsen, who in 1997 was awarded the Nordic Council Literature Prize for Bang: En roman om Herman Bang. Marina Allemano’s English translation of Bang, generously supported by the Danish Arts Foundation, is now ready for an English-speaking readership.
Bang relates the life story of the notorious author Herman Bang. The title of Willumsen’s novel might be a play on both his extravagant life and his sortie, as Bang’s life came to a sudden end while he was doing a reading tour across the USA. His last days form the back-story of Willumsen’s novel, a novel that weaves fiction and fact together in a touching and exciting portrait of an extraordinary man leading an extraordinary life (read an extract from the novel here).
Willumsen was at first supposed to write a traditional biography about Bang, and she did months of reading and researching previous biographies, his literary works and journalism and his thousands of letters, but the story fired her imagination to the extent that the book became a fictional biography, which describes Bang’s life from the inside rather than the outside. We first encounter Bang in New York, where he is starting out on his USA tour. The city is a grim, grey and loud place, according to Bang, and he is happy to board the train to escape from it, although he seems to want to escape the tour altogether. Unfortunately for Bang, the tour must go ahead, but he does find a way to escape – into his dreams. He dreams of his life, starting with his childhood: his mentally ill father and his beloved mother. Good, bad, sweet and sore memories are mixed and presented to the reader through young Herman’s eyes. As the story progresses we follow him throughout the USA, and in his flashbacks throughout his life. We get to know his youthful infatuations with young men and women, his bohemian life full of wonders but also scandals, his travels and life in different cities in Europe – from Copenhagen to St. Petersburg to Prague, and we discover the hardships he suffered as a well-known writer and a homosexual.
As well as a novelist Bang was a journalist, critic and playwright, as well as an actor and a theatre director. Because of this, he was omnipresent in Danish cultural life. He often wore eccentric clothes that shocked the conservative public, and of course, his homosexuality shocked them even more. His first novel was banned for immorality, as much for its content as for the writer himself.
But although Herman Bang was viewed as what we might now call an attention-seeking drama queen, his novels often focus on quiet, downtrodden people who do not raise their voices; people with a lack of agency; people who seem to accept the fate that society has in store for them. These stories of Stille eksistenser (Quiet Lives) are what made him a celebrated and loved author in Denmark. One example is the novel Tine from 1889. This novel interweaves the Prussian invasion of Denmark with male invasion of female innocence. Tine is a young girl who takes up the housekeeping chores at the neighbouring farm, owned by the charming and handsome Henrik Berg, who has just seen his wife and son shipped off to Copenhagen because of the war. Henrik and Tine become intimate, despite her being much younger and far below him in class – although Henrik is a decent man. Tine is inexperienced and mistakes desire for true love. This is her downfall, and when she realises that Henrik in fact never loved her, she drowns herself.
It seems that the love Bang always wrote about, was the kind of love that fails or the kind of love that cannot be fulfilled. Maybe he saw parallels with his own life, or maybe not – the kind of love that cannot be fulfilled is always novel material. He did write an essay, published in 1922, after his death, where his thoughts on his own kind of love seem rather grim. He writes that homosexuality is a harmless mistake in nature, and he expresses the hope that future medicine will not only cure homosexuality, but prevent it altogether. This tragic conclusion, in which Bang converts the hostility of his own times into a form of self-abnegation, is contextualised by an Afterword by Dag Heede, a leading Danish queer theorist.


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2 edition of book of the winter found in the catalog.
book of the winter
Sitwell, Edith Dame
|Statement||compiled by Edith Sitwell.|
|The Physical Object|
|Pagination||, 114 p.|
|Number of Pages||114|
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Follett’s new, magnificent historical epic, the Century Trilogy, includes the bestselling Fall of Giants, Winter of the World, and Edge of Eternity. He lives in England with his wife, Barbara/5(K).
After reviewing hundreds of books that swept their way into ESSENCE offices over the last few months, we’ve paired down the 24 books we’re really excited to read this winter.
These are books that he has read and thinks I also would enjoy so if he recommends a book, I will read that book. The Winter Room is a Newberry Medal Honor Book from It is the story of a family living on a farm in rural Minnesota and is told by the youngest member of that family, an 11 year old boy named Eldon/5.
In Book Lists, Books & Reading. Winter is historically not my favorite season, but there’s plenty to love about winter reading: the cold, grey days are the perfect excuse to stay inside and read.
The Danish concept of hygge is still having its moment, and for good reason: it encourages us to indulge in the seasonal aspects of life by being. The Winter of the Witch plunges us back to fourteenth-century Moscow, where old gods and new vie for the soul of Russia and fate rests on a witch girl’s slender shoulders.
Prepare to have your heart ripped out, loaned back to you full of snow and magic, and ripped out some more.”—/5(5K). 19 of the Best Books to Read This Winter. This book is one for those who need a prod from destiny, but also those who don't believe in such lofty promises.
(January 9, G.P. Putnam's Sons) Occupation: Senior Editor. In The Little Winter Book of Gnomes, Sevig invites readers into a cozy wonderland of her own prolific imagination. With recipes for holiday favorites like mulled cider and gingerbread, this book is the perfect gift to inspire readers to take joy in all of winter’s little happy-makers/5(34).
Winter is the fourth and final book in The Lunar Chronicles by Marissa Meyer. This book features Winter (loosely based on Snow White), and takes place on Luna. It was released on Novem Audio length: 23 hrs and 30 mins. Spend more time reading and less time figuring out what to read.
Choose from five monthly reads, vetted by cool people with great taste. Start reading today. Buzzy novels, compulsively readable non-fiction, and a few guilty pleasures for every reader in winter — the best books of the year.
The Complete Book of the Winter Olympics: Edition [Wallechinsky, David, Loucky, Jaime] on *FREE* shipping on qualifying offers.
The Complete Book of the Winter Olympics: EditionCited by: 9. About Winter. The second volume in his autobiographical quartet based on the seasons, Winter is an achingly beautiful collection of daily meditations and letters addressed directly to Knaugsaard’s unborn daughter 2 December – It is strange that you exist, but that you don’t know anything about what the world looks like.
Part mystery, part war story, part romance, The Winter Soldier is a dream of a novel - impeccably researched and totally immersive. The unsinkable Margarete is a mesmerizing character, and the book's investigation into the psychiatric toll of war on its combatants could not be more timely.
This novel convinces you with every sentence. Winter of the World picks up right where the first book left off, as its five interrelated families - American, German, Russian, English, Welsh - enter a time of enormous social, political, and economic turmoil, beginning with the rise of the Third Reich, through the Spanish Civil War and the great dramas of World War II, up to the explosions.
The Thirteenth Tale by Diane Setterfield is one of my favorite books. With a Gothic, timeless feel and a mystery that will keep you guessing until the end, The Thirteenth Tale is perfect reading for cool fall and winter nights.
In fact, the protagonist mentions drinking hot cocoa while reading several times throughout the book — it warms her during her mid-winter nights on the English Author: Erin Collazo Miller. The final book in the #1 New York Times- and USA Today-Bestselling Lunar Chronicles series by Marissa Meyer like you’ve never seen it before, now with new cover art!As the story draws to a close, our team of fairytale heroines must join forces with wicked Levana's own stepdaughter to stop the evil space queen once and for all—or lose everything/5().
ISBN: Visitors from the Other Side. The Secret Diary of Sara Harrison Shea. Janu The first time I saw a sleeper, I was nine years old. It was the spring before Papa sent Auntie away--before we lost my brother, Jacob.
My sister, Constance, had married the fall before and moved to : Knopf Doubleday Publishing Group. Winter solstice books for kids serve as a gentle reminder of the cyclical nature of the changing seasons. This collection of Children's winter solstice books contain illustrations, stories, information, and/or tales about the winter solstice for children of all religious backgrounds.
From award-winning author Eva Stachniak comes this passionate novel that illuminates, as only fiction can, the early life of one of history's boldest women. The Winter Palace tells the epic story of Catherine the Great's improbable rise to power - as seen through the ever-watchful eyes of an all-but-invisible servant close to the throne.
About Winter. Shortlisted for the British Book Award – Fiction Book of the Year and the Orwell Prize for Political Writing One of the Best Books of the Year: New York Public Library, Kirkus Reviews The second novel in the Man Booker Prize–nominated author’s Seasonal cycle; the much-anticipated follow-up to Autumn (a New York Times, Washington Post, NPR, Financial.
E-BOOK. Kindle Nook Apple Books Google Play Kobo. AUDIOBOOK (Download) Audible Apple Books. Winter Garden. Description. From the author of acclaimed national bestseller Firefly Lanecomes a haunting, heartbreakingly beautiful novel that illuminates the intricate mother-daughter bond and explores the enduring links between past and present.
The Winds of Winter is the planned sixth novel in the epic fantasy series A Song of Ice and Fire by American writer George R. Martin. Martin believes the last two volumes of the series will total over 3, manuscript pages.
They will take readers farther north than any of the previous books, and the first of the two will feature the Others. Martin has refrained from making hard Author: George R. Martin.
"This book is truly epic The reader will probably wish there was a thousand more pages." —The Huffington Post Picking up where Fall of Giants, the first novel in the extraordinary Century Trilogy, left off, Winter of the World follows its five interrelated families—American, German, Russian, English, and Welsh—through a time of enormous /5().
“In the midst of winter, I finally found there was within me an invincible summer.” Why do you think Isabel Allende chose to include this quote from Albert Camus in the book’s epigraph, title, and final scene.
Most of the story literally takes place during the winter.4/4(9). Winds of Winter chapters: Ever since A Dance with Dragons was released, fans have been wondering when the next book will be published.
While the pressure hasn't sped up his writing, GRRM had Author: Caitlin Petrakovitz. Pre-publication book reviews and features keeping readers and industry influencers in the know since Gertie, dies in during a harsh and unforgiving winter in which her mother and father, Martin, struggle to keep food on the table.
Gertie isn’t the first child Sara has lost, but her death is the one she has the most difficult. From the very first sequence here (a white milk-cart horse bounds over the newly-built Brooklyn Bridge in a bid for freedom), Helprin makes it clear that he's out to conquer the Latin-American-style genre of magic realism—with splendid worlds of the impossible-made-possible, with concentrated storytelling designed to vibrate and shine on each page.
The white horse. I've really liked all of A.G. Riddle's other books. The premise of the book was quite good, but the execution was a bit weak. The Long Winter, Doesn't focus enough on the “winter apocalypse" and its effects on mankind.
It is used mostly for set up to a space combat story/5(1K). Winter of the World is a historical novel written by the Welsh-born author Ken Follett, published in It is the second book in the Century ing about a family saga that covers the interrelated experiences of American, Russian, German and British families during the 20th century.
The novel follows the second generation of those families, born to the main Author: Ken Follett. Enhance Your Book Club Meeting for Winter Garden.
If you usually go out to dinner before your meeting—or eat during it–why not prepare one of the featured recipes. Or if life is too hectic for you to spend time in the kitchen, stop by your local store and pick up some frozen pierogies.
What really matters is the company and the laughter. The Winter Soldier Book is a book with the information regarding the Winter Soldier Program like how to open the HYDRA Siberian Facility and the trigger words to activate the Winter Soldier.
During HYDRA's mental reconditioning of Winter Soldier, a string of code phrases were implanted into his mind: "Longing, rusted, seventeen, daybreak, furnace, nine, benign, homecoming, Comic: Spider-Man: Homecoming Prelude.
Critic, Book World September 4, at PM EDT The beauty of Daniel Mason’s new novel, “The Winter Soldier,” persists even through scenes of unspeakable agony. Parents need to know that The Dogs of Winter, based on a true story, is a harrowing account of 5-year-old Mishka, who's left to fend for himself on the streets of Moscow in the years after the Communist regime fell.
It's a violent, harsh story with frequent descriptions of punching, hitting, kicking, scratching, and biting.5/5. The NOOK Book (eBook) of the The Red Winter (The Tapestry Series #5) by Henry H. Neff at Barnes & Noble. FREE Shipping on Brand: Random House Children's Books.
His books broke new ground in political science, emphasizing politicians’ interactions not in Washington but in their home districts. By Neil Genzlinger ‘The Arab Winter,’ by Noah Feldman. Pre-publication book reviews and features keeping readers and industry influencers in the know since her habit of hoarding food despite the family’s prosperity and the significance of her “winter garden” with its odd Cyrillic-inscribed columns.
The only thawing in Anya’s mien occurs when she relates a fairy tale about a.My Book of Winter Words Students copy the winter word on each page and associate it with the image on the page. On the final page, they draw a picture and write the word that describes it.
THE WINTER FORTRESS The fire raged “for more than seven hours and reached temperatures of degrees more than one million books were burned or damaged.” Though nobody was killed, 22 people were injured, and it took more than 3 million gallons of water to put it out.
One of the firefighters on the scene said, “We thought we were.


U.S. President Joe Biden is ordering more intel investigation into the origin of COVID-19.
On Wednesday, Biden ordered U.S. intelligence officials to strengthen their efforts to investigate where the virus originated, including any possibility that COVID-19 may have been manufactured inside a Chinese laboratory.
The Biden administration is joining worldwide scrutiny of China for their lack of transparency surrounding the outbreak. The GOP has complained that Biden has not pushed China hard enough on the matter.
The president is requesting that U.S. intelligence agencies provide their findings within 90 days. Biden has asked U.S. national laboratories to assist with the investigation and the intelligence community to give a list of specific questions for the Chinese government. He is also asking for China’s full cooperation with the international probes.
Many Republicans, including former President Donald Trump, have pushed the theory that the coronavirus was created by a laboratory accident as opposed to human contact with an infected animal in Wuhan, China.
In a statement, Biden said that most of the intelligence community had landed on two scenarios about how the virus originated but “do not believe there is sufficient information to assess one to be more likely than the other.” He confirmed that two agencies believe the animal link theory, while one is convinced that a lab event is the true source.
However, Chinese officials accused the U.S. of politicizing the pandemic and said that international experts had “repeatedly praised China’s open and transparent attitude” to Covid-19’s origins.
“Some people in the United States completely ignore facts and science,” Chinese Foreign Ministry spokesman Zhao Lijian told reporters on Thursday.
He added that a World Health Organization probe had already ruled out the probability of a lab leak.
China’s ruling Communist Party has been criticized by some world leaders and scientists for not raising the international alarm quickly enough over the coronavirus outbreak and for reprimanding Wuhan doctors who did so, among them Dr. Li Wenliang, an ophthalmologist who later died of the virus.
Zhao also disparaged the U.S. intelligence community — charged by Biden with looking deeper into Covid’s origins — as “unreliable.”
“The world is familiar with the dark past of the U.S. intelligence agencies,” he said, listing U.S. involvement in wars in Iraq and Syria.


BMW 5 Series Carbon Edition launched, prices start from Rs 66.3 lakh
BMW has added a new variant to the 5 Series lineup in India at a slight price hike over the standard 5 Series. The BMW 5 Series Carbon Edition receives changes to the design elements, but it remains identical to the standard 530i in terms of mechanicals, which means it will be offered solely with the 2-litre turbo-petrol engine. It will also receive similar levels of equipment as the standard 5 Series.
BMW 5 Series Carbon Edition Design
The 5 Series was always a gorgeous looking car, and the BMW 5 Series Carbon Edition continues the same theme. It receives a new Alpine White shade, along with certain elements finished in carbonfibre, such as the kidney grille, front splitter, rear spoiler, and the rearview mirrors. Additionally, the 18-inch wheels are also finished in Jet Black, and it sports Pirelli Sport 4 ZP tyres. The sleek headlights are all-LED units, as are the tail lamps with an L-shaped pattern.
BMW 5 Series Carbon Edition Powertrain
The BMW 5 Series Carbon Edition is powered by a 2-litre four-cylinder turbo-petrol engine which produces 248bhp at 5200-6500rpm and 350Nm of torque at 1450-4800rpm. This powerplant is mated to an eight-speed automatic transmission, the 5 Series Carbon Edition is capable of doing a 0-100kmph run in 6.1 seconds, maxing out at a top speed of 250kmph.
BMW 5 Series Carbon Edition Interiors and Equipment
The interiors of the BMW 5 Series Carbon Edition follow the dark theme as seen on the exterior elements, and receive the perforated Sensatec trim now finished in a combination of Cognac and Black. In terms of equipment and features, the Carbon Edition is nearly identical to the regular 530i M Sport. The Carbon Edition gets BMW Live Cockpit Professional equipped with BMW Operating System 7 and a 12.3-inch digital display. Additionally, it also receives 3D Navigation, a 12.3-inch touchscreen infotainment system, BMW Gesture Control, BMW Virtual Assistant, and a 16 speaker Harman Kardon surround system among many others. The driver assistance system includes Parking Assist with Surround View Camera, Reverse Assist, and Remote-Control Park function.
There’s also the BMW Safety Suite which includes six airbags attentiveness assist, dynamic stability control, dynamic traction control, electronic differential lock control, cornering brake control, and auto-hold electronic handbrake among others.
BMW 5 Series Prices and Rivals
The BMW 5 Series Carbon Edition commands a premium of Rs 2.9 lakh over the standard 5 Series, and is priced at Rs 66.3 lakh. Though the Carbon Edition itself does not have any direct rivals, the 5 Series generally goes up against the Mercedes-Benz E-Class, Audi A6, and the Volvo S90 that just received an upgrade recently. You can read more about it here.


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Editor’s notice: Discover the newest COVID-19 information and steerage in Medscape’s Coronavirus Useful resource Heart.
Outpatient COVID-19 remedy with monoclonal antibodies or antiretroviral medicines akin to nirmatrelvir-ritonavir (Paxlovid) administered to sufferers with systemic autoimmune rheumatic illness led to decrease odds of getting extreme outcomes when put next with related sufferers who acquired no outpatient remedy in a real-world, retrospective evaluation of circumstances.
Investigators discovered that there have been 9 hospitalizations or deaths (2.1%) amongst 426 sufferers who acquired outpatient remedy in contrast with 49 (17.6%) amongst 278 who didn’t obtain outpatient remedy, yielding an odds ratio of 0.12 (95% confidence interval, 0.05 – 0.25), after adjusting for age, intercourse, race, comorbidities, and kidney operate. The research was printed in Lancet Rheumatology.
“Throughout the board, there was a very sturdy affiliation with receiving outpatient remedy and decrease danger of extreme COVID-19,” senior writer Jeffrey A. Sparks MD, MMSc, assistant professor of drugs, Harvard Medical College and Brigham and Girls’s Hospital, Boston, Massachusetts, instructed Medscape Medical Information. “It’s fairly highly effective proof that on this high-risk group, that remedy nonetheless issues associated to stopping extreme COVID. We discovered nearly all sufferers who had extreme COVID-19, both hospitalized or who had died, have been within the untreated group.”
Early Outpatient Therapy an Necessary Device in Sufferers With Rheumatic Illness
Sparks famous that he and coinvestigators carried out the research as a result of the good thing about outpatient COVID-19 remedies in people with systemic autoimmune rheumatic illness was not adequately decided in scientific trials as a result of that they had rare enrollment of such sufferers.
The evaluation included 704 sufferers with a imply age of 58.4 years who have been seen at Mass Common Brigham Built-in Well being Care System, a multicenter healthcare system that features 14 hospitals and first care or specialty outpatient facilities within the Boston, Massachusetts, space. A majority have been feminine (76%) and White (84%). Almost half had rheumatoid arthritis. Of the 704, 426 (61%) acquired outpatient remedy, which included nirmatrelvir-ritonavir (n = 307), monoclonal antibodies (n = 105), molnupiravir (n = 5), remdesivir (n = 3), and mixture remedy (n = 6).
The findings underline the necessity to individualize approaches to outpatient remedy in those that take a look at constructive for SARS-CoV-2 to fend off extreme COVID-19, in keeping with Sparks. “It appears if you’re vaccinated and within the normal inhabitants that you’re means much less prone to have extreme COVID-19 within the present surroundings, however that does not essentially apply to some high-risk teams like sufferers on immunosuppression,” he mentioned. “There are nonetheless sufferers susceptible to extreme COVID-19, and a few of them are on this group of rheumatic sufferers. This needs to be a part of the dialogue associated to deciding whether or not or to not deal with.”
Sparks famous that vaccination towards COVID-19 confers safety towards creating extreme COVID-19 in sufferers with rheumatic illness because it does within the normal inhabitants, however sufferers with rheumatic illnesses stay at elevated danger for extreme presentation. “Actually, the vaccines actually assist our sufferers too, however there’s nonetheless a little bit of a spot between the chance for our sufferers with rheumatic illnesses and the final inhabitants” in creating extreme COVID-19, he mentioned.
Sparks mentioned he hopes the outcomes signify a “name to motion” that even amongst vaccinated sufferers there are nonetheless some who’ve poor outcomes, and that early outpatient remedy seems to be an necessary software within the struggle towards poor outcomes from SARS-CoV-2 an infection.
The research additionally reported on the phenomenon of COVID-19 rebound (recurrence of signs and take a look at positivity after routine completion) after oral outpatient SARS-CoV-2 remedy. “This [COVID-19 rebound] is a draw back to remedy,” he mentioned. COVID rebound was not rare: A complete of 25 (8%) of 318 sufferers who acquired oral outpatient remedy had documented COVID-19 rebound.
“It was reassuring as a result of we discovered nobody who had rebound progressed to have extreme COVID-19,” Sparks mentioned. “Alternatively, [rebound] occurred fairly steadily in our knowledge, as 8% of sufferers are documented to have it.”
Sparks mentioned he and coinvestigators speculate that extra sufferers within the cohort could have skilled COVID-19 rebound however didn’t talk this to their healthcare suppliers, and, as such, it was not documented within the medical file. The potential improvement of COVID-19 rebound “is one thing to counsel your sufferers about,” he mentioned. COVID-19 rebound is a phenomenon that’s being mostly noticed with nirmatrelvir-ritonavir as outpatient remedy.
Doable Confounding Components in Examine
Katie Bechman, MBChB, scientific lecturer in rheumatology at King’s Faculty London in the UK, who coauthored an accompanying editorial concerning the research and its findings, identified that the research is proscribed by its observational design.
“With any research that appears on the efficacy of remedy, particularly in an observational cohort, you are going to have to contemplate the unmeasured confounding and the distinction between these two teams,” Bechman mentioned. “I do know that they did attempt to alter for that on this research, however there’s all the time going to be elements that we won’t [control for]. That’s one thing that must be thought-about. I believe that is all the time one thing we have to take into account once we’re taking a look at observational knowledge.”
In lieu of a randomized, managed trial, Bechman famous that the research and its related findings function “one of the best knowledge now we have,” and he or she described the outcomes as “very informative and constructive.”
She added that the massive variety of sufferers represents a energy of the research, as does the sturdy methodology employed for figuring out which sufferers had COVID-19.
The learnings from this research with respect to outpatient remedy may be utilized to extra widespread diseases that sufferers with rheumatic illness could develop, such because the flu, in keeping with Bechman.
“One of many constructive features from this pandemic is that we have realized an enormous quantity about how greatest to deal with sure viruses and forestall them in sufferers,” she mentioned. “It will be value considering in the direction of the longer term, what we will do for diseases that we see very generally in these populations. There could also be remedy regimens that we have not actually thought-about till now. You would hypothesize that within the subsequent couple of years, if now we have an influenza breakout, that we needs to be offering some prehospital antiviral remedy to sufferers, particularly those which might be at excessive danger.”
Lancet Rheumatol. Revealed on-line January 23, 2023. Full textual content, Editorial
The research was carried out with out exterior funding. Sparks has acquired analysis help from Bristol-Myers Squibb and consulted for AbbVie, Amgen, Boehringer Ingelheim, Bristol-Myers Squibb, Gilead, Inova Diagnostics, Janssen, Optum, and Pfizer unrelated to this work. Bechman reported no related monetary relationships.
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domain: medical


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Excruciating pain leads to double hip replacement for young mom
For years Morgan Phillips and her doctors assumed strained muscles and ligaments surrounding her hip joint caused her chronic hip pain.
A soccer and field hockey player, she tried massages and physical therapy, but her hip pain that started in high school never went away. The Chesapeake native continued to play soccer into her 30s despite the discomfort.
"The pain never really went away," says Morgan, 35, a project manager for a nationwide payroll and human resources company. "I just began to tolerate and figure this is how things would be."
Pregnancy and hip pain
Morgan's hips became excruciatingly painful during her pregnancy. With her tiny frame, Morgan and her doctor chalked it up to pregnancy issues and the baby's weight.
"The pain didn't go away even after I had my daughter," notes Morgan, who, with her husband, John, became increasingly concerned. "By the time Ava was six months old, everything was so difficult, I knew I had to see an orthopedist."
Neighbors in Virginia Beach recommended Sentara orthopedic surgeon Dr. Joseph Gondusky. X-rays showed that Morgan had a collapsed femoral head on her right hip.
This condition, called osteonecrosis, occurs when the blood supply to the head of the femur is disrupted. The top of the femur makes up the "ball" of the ball and socket hip joint. Because bone cells need a steady supply of blood to stay healthy, osteonecrosis can ultimately lead to the destruction of the hip joint and severe arthritis, according to the American Academy of Orthopaedic Surgeons (AAOS).
"Getting the news that I would need a hip replacement at such a young age took me a good week to process," Morgan recalls. "It was mentally challenging thinking that this is how the rest of my life will be, and they said it was just a matter of time before the other hip bone collapsed."
The average age for hip replacement surgery is 65 years, according to an AAOS study. However, younger patients are becoming more interested in joint replacement surgery due to less invasive procedures and surgical advances that allow for quicker recoveries.
Surgery, recovery and another surgery
Dr. Gondusky performed Morgan's first hip replacement surgery at Sentara Leigh Hospital. He used the anterior approach, which means the surgeon reaches the hip joint from the front rather than the side or back of the thigh. With this approach, surgeons avoid cutting through muscles, speeding up patients' recoveries.
An orthopedic surgeon replaces the damaged ball-and-socket joint with a metal ball-and-socket during hip replacement surgery. A plastic or ceramic spacer inserted between the new ball and the socket creates a smoother gliding surface.
Morgan was out of bed a few hours after surgery, walking down the hall with a therapist.
"I dropped off my daughter at daycare in the morning with my husband, had surgery, and we were able to pick up my daughter in time for dinner," Morgan says.
Her recovery advice? Listen to your body and keep up with physical therapy.
"I tried different ways to exercise but walking was the number one activity that helped with my recovery," Morgan explains. "I got up every 30 or 40 minutes. Movement was the key."
Second surgery needed
A few months after her first surgery, Morgan could feel her left hip giving away. So again, in excruciating pain, she visited Dr. Gondusky, and they planned her second hip replacement.
Morgan underwent the same procedure at Sentara Leigh. Her recovery went even faster this time because she had a healthy, healed right hip to lean on.
Like many other patients, Morgan suffered in silence for a long time before her pain became unbearable. She wishes she had looked for answers sooner.
"This surgery has given my life back to me," she emphasizes. "I can go on long walks, pick up my daughter without cringing and even get out of bed without pain. Before this, I could never get comfortable. These surgeries have improved every aspect of my life. I feel like a teenager again."