Eddy Current Tee Joint Weld Flaw Specimen-ECT (Metric Version)
Eddy Current Tee Joint Weld Flaw Specimen-ECT-ET
ET Weld Specimen Specially made for Surface Eddy Current Testing with embedded flaws & coated with primer, epoxy paint & Teflon, Tee Joint weld
Geometry: 300mm (L) X 200mm (W) X 100mm (H) X 15mm (T)
Flaws: 3 per specimen, randomly placed Specimen Tolerance: +/- 0.080"
Documentation: NDT Verification Reports, C of C, CAD Drawings and Test Sheets.
Material: Mild Steel


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- Episode 64
- Posted September 5, 2021
This is a Great Country
In this series of postcards and letters from June of 1928, HPL tells his aunts Lillian Clark and Annie Gamwell all about his wonderful summer vacation in Vermont with Vrest Orton. The trip inspired several elements that would later find their way into his classic story "The Whisperer in Darkness".
Music by Troy Sterling Nies. Thanks to Hippocampus Press for their Letters to Family and Family Friends. Special thanks to Donovan and Pamela Loucks for guiding Sean and Dave Robertson through some of these sites, and to Michael Weitzner and The Occupant Who Must Not Be Named for being such gracious hosts in Vermont.
All of the postcards and letters we discuss this month are viewable in the Brown Digital Repository, but you can see the fronts of some of them below. June 12th. June 14th.
Here are some of the many fun photos taken of Lovecraft while he was on this trip. He posed next to Vrest Orton with a yoke of milk pails over his shoulders. He posed in front of the Goodenough house with poet Arthur Goodenough (left) and publisher J. Paul Cook (right). And he posed with the Lee boys, Orton's summer neighbors, with whom he rounded up at least one stray cow.
On their recent trip to New England, Sean and Dave Robertson got to visit some of the very places HPL describes in these letters. Davey took these photos of the house where Orton and Lovecraft stayed, and of Arthur Goodenough's house, now being preserved as a historical site. As soon as we know more about how we can help with that effort, we'll be sure to post an update! Top row: the house where Lovecraft stayed with the Orton family, now made bigger in every direction. Bottom row: the exterior and interior of the home of Arthur Goodenough, where HPL convened with literary notables of Vermont.
Lovecraft's trip was mentioned in the local Vermont papers a couple of times. Vrest Orton wrote what HPL himself described as a "puff piece" that was published in Charles Crane's "Pen-Drift" column in the Brattleboro Reformer on Saturday, June 16. (The Pen-Drift column made an appearance in "The Whisperer in Darkness".) And on the 18th, on the same day Amelia Earhart landed in Wales, Lovecraft's name was (almost correctly) included in a brief unsigned item about the literary convention held at Goodenough's house.
Lovecraft met rustic painter Bert Akley, who inspired the character of Henry Akeley in "Whisperer". We stumbled across one of his paintings online!
Charles Crane, of the "Pen-Drift" column, also worked in advertising and gave HPL a number of advertising brochures as souvenirs of his trip. We don't know if any of them survive, but we did find this nifty travel brochure about Vermont in the 1920s published by the Vermont Bureau of Publicity.

domain: artistic


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24 April 2019
Audience and press reviews of Britten's grand opera, directed by Deborah Warner.
3 April 2019
Join the cast and creative team including Toby Spence, Deborah Warner and Ivor Bolton as they explore Britten's opera.
20 March 2018
The Royal Ballet and Royal Opera's programme for the coming Season include world premieres, major new productions and classic revivals.
25 May 2017
The ROH has been home to major opera premieres dating all the way back to our first resident composer Handel – as material from ROH Collections shows.
28 April 2017
From dastardly demons to boozy brothel owners – we give the low-down on opera’s best bass roles.
17 February 2015
Building a ship on stage might be a stage designer’s nightmare, but life on or by the sea has made ideal material for some of opera’s greatest stories.
22 November 2013
Music and life of one of the greatest composers of the 20th-century marked by live performances and broadcasts.
28 June 2013
A look over this troubled relationship – and the glorious operas it produced.
8 June 2013
The British tenor on the challenges and rewards of five of Britten's rarely performed gems.
29 April 2013
A look at five works created in parallel to the composer's iconic post-war operas.

domain: entertainment


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The Turkish Athletics Federation today banned Nevin Yanit, the former European 100m hurdles champion, for two years for a doping violation as the organisation continues its clean-up process in the wake of drugs scandals in the sport in the country.
The TAF said Yanit, who won the European hurdles title at both the 2010 and 2012 competitions, tested positive for a banned substances during a meet in Dusseldorf, Germany on February 8.
She was charged with the doping violation in May, along with Asli Cakir Alptekin, the winner of the women’s 1,500 metres at the 2012 Olympics. Alptekin's case is still being assessed, but she faces a lifetime ban having already served a two-year suspension for doping in 2004.
The TAF said in a statement today: "After her B sample also tested positive, the disciplinary board asked for Yanit's defense and decided to ban the athlete for two years following deliberations."
Ugur Erdener, president of the Turkish Olympic Committee, claimed today's sanction on Yanit "demonstrates that the new, more aggressive anti-doping policies being implemented by our national federations and the Turkish Anti-Doping Agency, actively supported by the NOC and the Turkish government, are rooting out drugs in Turkish sport."
He said: "While any evidence of cheating is a major disappointment for any country, the Turkish NOC nevertheless welcomes the action taken by the Turkish Athletics Federation today. The top-down approach is sending a clear message to cheats and would-be cheats in Turkey: you have nowhere left to hide. Turkey’s rigorous programme of testing and sanctions will be intensified further when the WADA-accredited anti-doping laboratory opens in Ankara later this year.
"Turkish sport is also redoubling its efforts in the bottom-up approach, putting a greater emphasis on education in schools, colleges and youth clubs nationwide. Our focus is on teaching young athletes, parents and coaches the dangers of doping, and making them better equipped than ever, through proper training and nutrition, to succeed the right way."
Erdener continued: "Our more aggressive approach will continue – and it may yet yield more positive tests and more sanctions. Our anti-doping programme is under the full glare of the global media spotlight and we welcome that. If we achieve our goal of more clean Turkish athletes winning more medals in more sports in the years to come, then our tough action today will have been worth it."
The Turkish NOC has been keen to show International Olympic Committee members that, with Istanbul hoping to be awarded the 2020 Olympic Games ahead of Madrid and Tokyo on September 7, action is being taken and that no stone will be left unturned in the fight to eradicate doping in the country.
Earlier this month, the TAF imposed two-year bans on 31 track and field athletes found guilty of doping violations just days after Mehmet Terzi resigned as head of the federation, a position he had held for nine years.
The group of 31 included three athletes who competed at London 2012, including hammer thrower Esref Apak, a silver medallist at the Athens 2004 Olympics.
The bans followed a wave of drugs tests conducted on Turkish athletes before and during the Mediterranean Games held on home soil in Mersin in June and the recent decision of the IAAF, track and field’s international governing body, to ban nine athletes, six of them women, including two teenagers, for two years each for taking anabolic steroids.

domain: news


No one formally complained, but the smirks—and a buzzing Reddit thread—spoke volumes.
A TTC map at Downsview Station of was taken down earlier this week following overwhelming public agreement that, yes, it looked rather like a penis.
The new map was erected in December as part of a signage switchover at the station but got a rise out of Redditors when posted online.
The TTC says the switchover of signgage was a bit of a rush job and thus a few steps of the process were skipped, which allowed the sign to be approved. According to the organization, a new map has already been designed and will replace the current one “ASAP.” Meanwhile, the TTC says it has identified the employee who designed the map—and, while it does not believe said employee made the map phallic on purpise, will nonetheless take a long, hard look at how designs get approved in the future.


Director and writer of Naughty Dog’s The Last of Us Neil Druckmann recently spoke to Eurogamer about his vision for the upcoming game. Druckmann emphasized the industry’s need to raise the standard for storytelling. He stated,
As critics we need to raise the bar, otherwise no-one’s going to change. We’re going to keep pushing ourselves, and kill ourselves to make this story happen – but hope that by doing it, the rest of the industry is going to take notice and try to do the same thing.
This is great news for the gaming industry as story usually takes a backseat to gameplay, and any genre of media needs these boosts to improve. He also stated that he felt core gamers might not respond well to the premise of The Last of Us, being “a love story about a father-daughter-like relationship.” But it may turn out to be a risk that launches gaming to a new level. The best titles are the most
2011 was generous year when it comes to fantastic titles that were released for the PS3. Here are the best games from a fruitful year in gaming!
Batman: Arkham City
Average Price: $59.99
Arkham city is a sequel to Batman: Arkham Asylum. The player controls the dark knight, in a third person action adventure game.
Batman’s goal is to rid Arkham of the proverbial villains who have escaped from the asylum and are wreaking havoc among the city’s denizens.
One of the top titles of the year, Batman: Arkham City is an appropriate gift for Christmas lists this holiday season.
Average Price: $59.99
Another big title for 2011 is EA’s Battlefield 3. Battlefield is a first person shooter in which the player controls a US Marine in single player and multiplayer combat that encompasses locales across the world.
Battlefield 3 has had quite the grudge match with Call of Duty when it comes to fans of both series. Battlefield supporters argue that it is more realistic and believable, and they are right.
With a mature rating, this game is certainly for hardcore gamers, so moms be warned!
Uncharted 3: Drake’s Deception is one of the most anticipated games of 2011. So does the release live up to its name, or will the hype that preceded Uncharted 3 be a deception itself?
This is where Uncharted 3 shines. There were moments during gameplay where I was completely sideswiped by the depth of the story and the development of all the characters. This installment of Uncharted dives into Nathan Drake’s characte Read the rest of this entry
If you are as excited about the PS Vita as I am, you should be aware of a few setbacks in the final release of the portable before you get the nerd giggles. For starters, the WiFi model is set to run at about $249.99 and the 3G/WiFi model will run at about $299.99, so you’ll be shelling out the price of a regular console. The 3G model doesn’t even include the price of a data plan. On top of that, it was just revealed that certain games such as Uncharted: Golden Abyss, Dream Club Zero, Disgaea 3, Hot Shots Golf 6, Monster Raider, and Ridge Racer will require the addition of a memory card. They will not be supported by the on board memory. The following memory cards will be available: 4GB memory card (US$29), 8GB memory card ($42), 16GB memory card ($72), and 32GB memory card ($124) (Kotaku). So if you want a hefty chunk of memory, and 3G speed for optimal online gaming, you could be spending about $425 plus a $15-$25 data plan. That’s a lot of dough, and if you ask me, other portables are better and more popular.
If the Vita comes built in with a nice os with an app store on par with Apple or Android, it could hold its own, but the popularity in the iPhone and Android phones are their accessibility and popularity among a huge demographic that conventional gaming consoles never dreamed of. iPhones are popular among young and old. I’ve seen many elderly addicted to Angry Birds, and my mother in law in particular (who is not into gaming at all) has several slot-machine and gambling-type games on her Android-run, T-Mobile myTouch. I thought this was a strength in the Xperia play, a playstation phone released by Sony, but it too seems to be missing something; it is as popular as Rebecca Black at a Metallica concert.
I’m not sure if I want a Vita anymore. Although I am a die hard Uncharted fan, I would be more interested in borrowing someone’s Vita for a weekend to play Golden Abyss, and invest my money in other console games. The Vita could turn out to be an outstanding piece of hardware, but that will have to be proven with its release. What are your thoughts on portable devices? Am I an utter imbecile? What innovation could make it for the PS Vita? Let me know in the comments.


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Bus service to Boston has been partially suspended and members of the Martha’s Vineyard Tactical Response Team have been called to report to Boston as much of the capital area remains on lockdown during a massive manhunt for one of the suspects in the deadly Boston Marathon bombing attack.
Members of the Island’s tactical team were first called to Boston on Wednesday afternoon for a 12-hour shift, from 6 p.m. to 6 a.m., Oak Bluffs Lt. Tim Williamson told the Gazette on Wednesday. The team returned Thursday morning, before being called back into service on Friday.
The tactical response team is a highly-trained group composed of members from Island police departments partially funded by Homeland Security money. Similar tactical response teams throughout the state, including at least two on Cape Cod, have been called this week to provide relief and assistance to Boston-area SWAT teams.
On Friday morning Peter Pan Bus issued an alert notifying that all service to and from South Station in Boston had been suspended. Limited service to and from Logan Airport to Woods Hole and Providence will continue and will bypass the South Station connection, a spokesperson for the bus company said. Logan Airport remains open to air traffic.
The news of the manhunt and accompanying travel restrictions comes as many Martha’s Vineyard students are making their way back to the Island at the end of school vacation week. Vineyard schools superintendent Dr. James H. Weiss said that two groups of students are scheduled to return from international trips today: the Minnesingers choral group, which was to return from Croatia today and take the 6:15 p.m. boat, as well as a group of German language students who traveled this past week to Germany.
Mr. Weiss said two busses from the school’s off-Island fleet have been dispatched to meet the students at the airport. The drivers “don’t know what they’re going to find as they get closer to Logan, but are on their way now so that they should have plenty of time to pick the kids up,” he said.
Martha’s Vineyard Airport manager Sean Flynn said in the wake of the bombings in Boston on Monday, the Island’s own airport has “increased our vigilance” of the “see something, say something” campaign. The airport has distributed flyers and posters around the airport and to tenants at the airport business park to report any unusual activity to law enforcement.
Mr. Flynn said the airport continues to have “routine” conversations with local, state and federal law enforcement.
“While the subject matter has changed, the only thing we’ve done differently is handed out the flyer,” he said.
Steamship Authority general manager Wayne C. Lamson said ferry operations are continuing as normal.


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"E! News" co-host Giuliana Rancic announced on Monday, October 17, that she has early stages of breast cancer.
The 37-year-old said during an appearance on "The Today Show," which can be seen below, that the cancer was discovered during a mammogram examination she had while she was undergoing a third round of in-vitro fertilization in an effort to get pregnant. Rancic has been open about her fertility problems and had a miscarriage in 2010.
Rancic said she will have surgery this week, followed by six and one-half weeks of radiation therapy.
The television host revealed that before she was set to undergo treatment her doctor advised her to get a mammogram to ensure that she did not have cancer before she went on hormone therapy. "He said, 'I don't care if you're 26 or 36, but I will not get you pregnant if possibly there's a small risk that you have cancer because the hormones will accelerate the cancer,'" Rancic said. "I wasn't prepared to get a mammogram until I was 40 years old, like I'd been told. I never in my wildest dreams expected anything to be wrong."
Rancic is married to Bill Rancic, winner of the first season of "The Apprentice." The couple married in 2007 and launched their own reality show, "Giuliana & Bill." "Bill is unbelievable," Rancic said about her husband and how the two have handled the news. "He lets me cry when I want to cry. He just lets me feel what I want to feel."
The television host also said she still wants to get pregnant because "this baby will have saved my life."
Rancic also had a message for other women about getting screened for breast cancer. "I think a lot of us think we're invincible. But we have to start putting ourselves on the to-do list," she said."I just want women out there to know if you can just find it early, you'll be OK. I found it early."

domain: celebrity


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OAKLAND — Waterville native Sean Doherty has returned to his home county as new Chef de Cuisine at Riverside Farm Restaurant and Wine Market. Most recently at The Corner Room and Boone's Fish House, Doherty said he's "working to bring a little bit of the collaborative spirit that exists in Portland to Central Maine," including guest chef and pop-up dinners. He plans to use the restaurant's 20+ acres of farm, onsite greenhouse, and vineyard to tailor his menu to what's in season. Owner Pamela Tyler said she's thrilled to have Doherty on board for the business' 25th year.
BELFAST — Ever a plant-friendly spot, The Gothic "is introducing an entirely vegetarian menu" this summer from new chef Matt Downes, per a press release. Almond gazpacho and curried sweet potato fritters with nettle chutney are a couple of the planned additions. Downes most recently cooked at famously locally-focused D.O.M., Brazil's first and only recipient of two Michelin stars. This is the fourth chef The Gothic has seen in the past year, following Jason Paul, Mike Mastronardi, and Ryan McKeown. Can Downes fill a more permanent role?
Update 5/28/15: A source noted, and a rep confirmed, that Ryan McKeown remains a sous chef at The Gothic, though he was in a leadership role before Matt Downes was hired.
PORTLAND — Tim Labonte has left his position as executive chef of The Westin's Congress Squared to return to Eve's at the Garden in a "newly created position as Regional Executive Chef for Hart Hotels," according to a release. The role will also include oversight of food service at the new Inn at Diamond Cove on Great Diamond Island, set to open in late June. Labonte will be joined by "Director of Food and Beverage" Eric Flynn, who comes to the Portland Harbor Hotel from the Harraseeket Inn in Freeport.


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Debbs Kitchen Adobo Seasoning is Salt Free!
Hand blended from cumin, paprika, coriander, fennel, yellow mustard, garlic, onion, ancho, pasilla, and Mexican oregano. Rub or sprinkle on seafood and meat before grilling or frying.
Good to use in chili, guacomole, black beans, red beans, tacos, stews and sauces.
All sales are final for food items including spices, spice blends, olive oil, and balsamic vinegar.

domain: food


text: A new breed of back-to-basics rock, Jack and Meg White have been a smash hit with critics and fans since their breakout album in 2002. Their use of lo-fi sound has single-handedly changed the face of rock and garnered them a spot in music history. But beyond their critical acclaim the group has been a media spectacle. Scandal first broke when they were exposed as actually ex-husband and wife, though they'd promoted themselves as brother and sister. Since then, lead singer Jack White has been a tabloid phenomenon, from his highly publicised romance with Renee Zellweger to his infamous tussle with the singer from the Von Bondies.


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Have you heard about GOTV? No, it's not a new television network. GOTV stands for the national "Get Out The Vote" effort.
Texas Secretary of State, Geoff Connor made a stop in Tyler today to push statewide get out the vote efforts, urging everyone to exercise what he calls an important civic responsibility. "We would really like for people in the Lone Star State to be excited about this year's election. We have the potential for record voter turnout," says Connor.
Connor says the state has set a new record high for registered voters. Right now, 13.1 million people are registered in Texas. That compares to 12.4 million in the 2000 election. Connor says the trick now is to get all those people to the polls and he would like to see more early voters.
The Smith County Elections Administrator says, through the first 9 days of early voting, 26,068 people have already cast ballots.

domain: sociology


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Shri Hardeep Singh Puri, Minister of State for Housing and Urban Affairs (I/C) has launched the Climate Smart Cities Assessment Framework (CSCAF) 2.0, along with the ‘Streets for People Challenge’ in a virtual event organized by the Smart Cities Mission, Ministry of Housing and Urban Affairs (MoHUA), here today. The objective of CSCAF is to provide a clear roadmap for cities towards combating Climate Change while planning and implementing their actions, including investments. In the last decade, an increasing frequency of cyclones, floods, heat waves, water scarcity and drought-like conditions have had adverse impacts on many of our cities. Such extreme events and risks cause loss of life as well as impact the economic growth. In this context, CSCAF initiative intends to inculcate a climate-sensitive approach to urban planning and development in India. Sh Durga Shanker Mishra, Secretary, MOHUA, senior officials of MOHUA and Ministry of Environment, Forest and Climate Change, Principal Secretaries (Urban Development) of State Government and UTs, State Mission Directors of Smart Cities Mission, Municipal Commissioners/CEOs of Smart Cities, representatives of partner agencies / Bilateral / Multilateral Institutions and other key stakeholders attended the function.
This assessment framework was developed after review of existing frameworks and assessment approaches adopted throughout the world followed by series of extensive consultative process with more than 26 organizations and 60 experts from different thematic areas. The framework has 28 indicators across five categories namely; (i) Energy and Green Buildings, (ii) Urban Planning, Green Cover & Biodiversity, (iii) Mobility and Air Quality, (iv) Water Management and (v) Waste Management. The Climate Centre for Cities under National Institute of Urban Affairs (NIUA) is supporting MoHUA in implementation of CSCAF.
As the lockdowns lift, cities face many challenges in providing safe, affordable, and equitable modes of transport that enable social distancing. Limited public transport options, narrow, crowded sidewalks particularly in market places and deterioration of mental health, are key issues that must be addressed on priority. Pedestrianisation of streets for walking and creating public spaces is a crucial step towards mitigating these issues. Cities around the world, such as Bogota, Berlin, and Milan have responded by transforming streets for walking and cycling, to ensure safe mobility during COVID-19.
The Streets for People Challenge is the response to the need for making our cities more walkable and pedestrian friendly. The Challenge builds on the advisory issued by MoHUA for the holistic planning for pedestrian-friendly market spaces, earlier this year. The Challenge will support cities across the country to develop a unified vision of streets for people in consultation with stakeholders and citizens. Adopting a participatory approach, cities will be guided to launch their own design competitions to gather innovative ideas from professionals for quick, innovative, and low-cost tactical solutions.
It aims to inspire cities to create walking-friendly and vibrant streets through quick, innovative, and low-cost measures. All cities participating in the challenge shall be encouraged to use the ‘test-learn-scale’ approach to initiate both, flagship and neighbourhood walking interventions. The interventions can include inter alia creating pedestrian-friendly streets in high footfall areas, re-imagining under-flyover spaces, re-vitalizing dead neighbourhood spaces, and creating walking links through parks and institutional areas. Fit India Mission, under Ministry of Youth Affairs and Sports, along with the India program of the Institute for Transport Development and Policy (ITDP) have partnered with the Smart Cities Mission to support the challenge.
For more information visit the site:


According to a top researcher, it is time to rethink the entire way we approach preschool.
Dale Farran is a half-century old and has been studying early childhood education. Her most recent scientific publication made her question everything she believed she knew.
"It took a lot soul-searching and a lot reading the literature to find plausible explanations for it."
She refers to the results of a study that lasted over a decade. There were 2,990 children from low income families in Tennessee who applied for free prekindergarten programs. The lottery selected some, while others were denied. This is the closest thing to a controlled, randomized trial in real life -- the gold standard for scientific proof of causality.
The Tennessee Pre-K Debate: Spinach vs. Easter Grass
The Tennessee Pre-K Debate: Spinach vs. Easter Grass
Farran and her Vanderbilt University co-authors followed both sets of children through sixth grade. As expected, children who attended pre-K scored higher in school readiness at the end of their first academic year.
However, after third grade they did worse than the control group. They were even worse by the sixth grade. They scored lower on tests, were more likely be in special education and were more likely get in trouble at school, including suspensions. Farran says that while in third grade, we had negative effects on one of three state achievement tests. In sixth grade, we saw the same effect on all three -- math science and reading. "In the third grade, we saw effects on one type suspension, which was minor violations. But, in sixth grade, we see it on both major and minor suspensions."
That's right. This study found that a state-wide pre-K program taught by licensed teachers and housed in public schools had a statistically significant, measurable negative effect on the children.
Farran didn't expect it. She didn't like it. She didn't like it. However, her study design was so strong that she couldn’t explain it.
"This is the only randomized controlled trial of a pre-K in statewide. I know people are upset and don't want this to be true."
It's not a good time to share bad news
Early childhood advocates are in a difficult time when they hear bad news about public preschool. The federally funded prekindergarten program for children aged 3 and 4 years old was a key component of President Biden’s social agenda. Talks are being held to revive it from the deadlock over the "Build Back Better” plan. Preschool funding has increased in recent years. It is now funded in some degree in 46 states. Around 7 out 10 4-year-olds are now enrolled in some academic program. This enthusiasm is based in part on research dating back to the 1970s. James Heckman, an economist, was awarded the Nobel Prize for his research that showed substantial long-term returns for investment in carefully designed programs.
It's been said that experts and policymakers have known for decades that giving a 4-year old who is living in poverty a lot of story time and block playing will increase their chances of becoming a productive, high-earning citizen.
What went wrong with Tennessee?
One study does not necessarily mean the end. Pre-K research continues to be mixed. A working paper, not yet peer-reviewed, was published in May 2021 that examined Boston's preK program. Farran's study was similar in size, it used a quasi-experimental design that relied on random assignment and followed up with students for many years. The study showed that preschoolers had better disciplinary records, were more likely to graduate high school, take the SATs, and go to college. However, their test scores did not show any difference.
Farran believes that a citywide program offers more quality control opportunities than a statewide one. The program in Boston spent more per student and was also mixed-income, while the program in Tennessee is only for low-income children.
What went wrong in Tennessee? Farran's ideas are challenging in every way. How teachers are trained, funded and where they are located. Everything from where the bathrooms are to how they're prepared.
Farran is, in short, rethinking her preconceptions about quality pre-K.
Are children in poverty entitled to the same education as those who are wealthy?
"One of my biases that I didn't examine in myself was the idea that children from low-income families need a different kind of preparation than children from higher-income families.
She is talking about teaching children basic skills. Worksheets to trace letters and numbers. A teacher gives a 10-minute lecture to 25 students who must sit still and listen. Only five may be paying attention.
She explains that families with higher incomes aren't choosing this type of preparation. "And why would you assume that we should train children from lower-income families sooner?"
Farran points out the fact that families with a lot of money tend to choose play-based preschool programs that incorporate movement, art, and music. Open-ended questions are asked to children and they are listened too.
Farran says this is not the case in schools with many poor children. Farran believes that teachers talk a lot but rarely listen to their students. Farran believes that this is partly due to the fact that many teachers are licensed in teaching prekindergarten through fifth grade, and sometimes even prekindergarten to eighth grade. Their training is very limited and does not focus on the youngest learners.
Another bias she challenges is that teacher certification is synonymous with quality. "Three large studies, including one from 2018, have not shown any correlation between licensure and quality.
Put a bubble in the mouth
Farran published a study in 2016 based on her observations in Tennessee pre-K classrooms, similar to the ones included here. The largest portion of her day was spent in transition. This simply means that children are moved around the building.
This is partly an architectural problem. Private preschools and home-based daycares are often designed with small bodies in mind. Bathrooms are located just outside the classrooms. The classroom is also a great place to eat with your children. There is also an outdoor playground with equipment that can be used by short-sighted children.
These same programs can be made more difficult by being offered in public schools.
"So, if you're in an elementary school older than the one you are currently attending, the toilet will be down the hall. Farran says that you need to get your children out and line them up, then wait. The same goes if you need to use the cafeteria. It's a walk through the halls. "
Farran's most fascinating conjecture is that this need to control could be the reason for the additional discipline problems she observed in her latest study.
"I believe children aren't learning internal control. They are actually learning an almost allergic reaction to the external control they have at school.
This means that if you reprimand or suspend children for doing normal child stuff at four years old, it could backfire later on as the children view school as a place with unreasonable expectations.
Other research has shown that school discipline can have a disparate impact on racial relations. Studies have shown that Black children in preschool are disciplined less often than those in higher grades. Farran's study of 70% of the children was white and found that there were interactions between race, gender, discipline problems, and even attendance at preschool.
Preschool Suspensions Are Real and That's Not OK with Connecticut
From here, where to go
COVID-19 has highlighted and intensified the child care crisis in America. Progressive policymakers and advocates have been trying for years to increase public support for child-care by "pushing down" the existing public schools system using the teachers and buildings.
Farran is a fan of the alternative direction New York City has taken: a mixed-delivery program that offers slots for children aged 3 and 4. Some children attend public preschool for free in existing non-profit day care centers, others in Head Start programs, and some in traditional schools.
Farran's research reveals that the greatest lesson is that pre-K has been asking too much, based on early results of what were basically showcase pilot programs. She says, "We want a miracle cure."
"Who would have thought you could give a 4-year old from an impoverished home 5 1/2 hours per day, nine months of preschool and close the achievement gap to send them to college at higher rates?" She asks. "I mean, why? Why are we putting so much pressure on pre-K programs?
She believes that letting children play can actually lead to better results.


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A Bollywood actress has defended her decision to pose naked for Playboy after she was accused of shaming India by stripping off.
Sherlyn Chopra has sparked outrage by becoming the first Indian woman to appear on the cover of the men's magazine, which is banned in the conservative country.
The 28-year-old beauty has yet to tell her Muslim mother about the pictures, but insists she has no regrets.
Chopra tells the Bbc, "My sister is proud of my achievement. I haven't told anything to my mother but I think I will visit her and tell her that she has to accept me the way I am. People feel that I have brought shame to the country but some have encouraged me as well."
Chopra's spread will appear in the upcoming November (12) issue of Playboy.
Celine Dion barely cracks a smile and yet she's the greatest guest yet.
Phildel has gone back a step, in terms of her musical compositions, and returned to a style more reminiscent of her debut album with her latest...
To promote the release of her latest album 'Designer', Aldous Harding has undertaken an extensive European tour. On Wednesday night Harding played to...


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Prestatyn is one fo the best seaside towns around with a great selection of things to do all day. You can shop all day at Prestatyn with a selection of shops including a retail park. Spend the day on the beach or do some activity that all your family will love. And is close to Ty Mawr Holiday Park.
North Hoyle Offshore Wind Farm is just off shore has 30 turbines.
Knightly’s Fun Park - with a vast range of ride to suit all thrill seekers and your families. A comedy show case is also here with some great acts to keep you entertained. A bar and restaurant where you can enjoy delicious homemade meals that even the pickiest of eaters will love. Try the Dodgem Cars an old family favourite or try The Waltzer another old family favourite, plus lots more rides for all ages.
Rhyl Beach - in North Wales, has a long sandy beach that your kids will love running along, plus, there’s even sometimes donkey rides! A traditional day at the beach with bucket and spade for all the family and there’s even a lifeguard service during summer too.
Rhyl SeaQuarium - come and see sea life from around the world, see sea lions playing in the water. Journey through the under water tunnel and see sea creatures swimming around you. Fantastic Phobias - see if you can face your fears Rats, Spiders or worse.
Kinmel Bay - in North Wales, a great beach that’s perfect for your family, Bring your beach tent and stop all day building castles and whatever you can think off. Seals can sometimes be spotted bobbing up and down in the sea.
Llanddulas Beach - is a rock and pebble beach with an area of wet sand exposed at low tide. The beach has two car parks and there is a small picnic area. From the beach there are views over Colwyn Bay.
Prestatyn Market & Carboot
Prestatyn Market & Carboot - you can come along to the market and find a bargin. You never know what can be found.
The Roman Bath House
The Roman Bath House - situated in what is now Melyd Avenue, on the edge of the small North Wales resort town of Prestatyn, about 20 miles west of Chester. This bath-house was built in about AD 120, with further extensions around AD 150. . It had a cold plunge-bath at the far end which was fed by a local spring by means of a timber aqueduct.

domain: travel


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RADIO GRAVEYARD ORBIT
July 2019, English, 4.25 x 9 in, 62 pages + 18 inserts, black & white, softcover, spiral bound
Edition of 150
Design: Sming Sming Books
Available Online @ Sming Sming and Printed Matter
RADIO GRAVEYARD ORBIT is a hybrid transmission—part text, part listening score—created in collaboration between installation/sound artist Andrea Steves and poet/dancer Laressa Dickey. Space Junk circles overhead. Literally, overhead, the global circulation of waste, commodities, and global extraction, in their own time. This waste extends beyond our physical boundaries, beyond the seen, beyond the speed and scale at which we can understand it. The text provides the atmosphere for the listening. The listening provides pause and interruption. RADIO GRAVEYARD ORBIT is designed to engender a sense of curiosity and connection, as well as specific instructions for ways of observing space/place around us. It seeks to grapple with the effects of capitalism, colonialism, bureaucracy on the literal space of the universe.
We are grateful for the support we received from Dickinson House, Olsene, Belgium, where this project began during a 2015 residency.

domain: design


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Tags » Greeks
READ THE INTERVIEW IN GREEK VERSION – HERE
William Shakespeare once said very aptly that “some are born great, some achieve greatness and some have greatness thrust upon them”; that phrase can describe perfectly our next interviewee, who has the ability to set goals and carry them out by just having natural gift. 1,735 more words
Answer me when I call to you, my righteous God. Give me relief from my distress; have mercy on me and hear my prayer.
How long will you people turn my glory into shame? 797 more words
1,305 more words
Now among those who went up to worship at the festival were some Greeks. 21 They came to Philip, who was from Bethsaida in Galilee, and said to him, “Sir, we wish to see Jesus.” 22 Philip went and told Andrew; then Andrew and Philip went and told Jesus.

domain: literature


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The Centre on Friday started registration for the Pradhan Mantri Kisan Maan-Dhan Yojana (PM-KMY), a pension scheme for farmers announced in the Union Budget. Under the PM-KMY, which was announced during the Budget 2019-20, a monthly pension of Rs 3,000 will be provided to eligible farmers on attaining the age of 60.
“Today, the PM-KMY registration process has commenced across the country. Till noon, 418 farmers have registered and I request more farmers to join the scheme,” Agriculture Minister Narendra Singh Tomar said announcing the launch of the scheme. The scheme will be implemented across the country, including Jammu and Kashmir and Ladakh, he said.
“Despite working hard, farmers do not earn enough. Therefore, ensuring social security is important. We have taken several measures to ensure better income and the PM-KMY is yet another effort towards this direction,” Tomar said.
The minister further said the government is aiming to double farmers’ income in the next five years. The Centre is in constant touch with states and making efforts to ensure all key schemes reach the farmers, he said.
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domain: economics


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December 12th, 2020
What is Vidalista?
Vidalista (tadalafil) is an oral erectogenic factor used for helping men with the negotiated erectile ability to obtain and maintain erections in a physical connection. Vidalista results set in 30 minutes following treatment and last during the ensuing 36 hours or for the weekend. While the result of Vidalista last, the user can perform as many erections as is excellent under the circumstances.
Erectile dysfunction (ED) is prevalent comorbidity in people living with diabetes. As many as 75% of diabetic men will be faced at some time in their lives with a chronic or recurrent failure to achieve and maintain an erection sufficient for sexual performance, typically at a more advanced age than their equals with normal glycemic control.
Not only does diabetes raise the chance of ED nearly twofold, but ED may also be the first sign of diabetes and was significantly ominous of neuropathic signs and poor glycemic control in 5-year prospective research. ED and diabetes affect >150 million people worldwide, and this cost is projected to increase by the year 2025.
What is Vidalista 20 used for?
Vidalista is applied to restore the capacity to respond with a hard and enduring erection towards sensual stimulation. In the case of intimate stimulation, the body reacts by providing a substance, the cyclic guanosine monophosphate (cGMP), which increases blood supply to the penis and creates an erection.
The greater the strength of this substance, the greater the intensity and duration of the erection. However, the body also naturally gives another reason, phosphodiesterase 5 (PDE5), which runs cyclic guanosine monophosphate. Consequently, if high levels of phosphodiesterase 5 are already in the body, the levels of cyclic guanine monophosphate are diminished and, even in the case of physical stimulation, an erection is not obtained or is negligible or not very enduring.
Who manufactures Vidalista?
Vidalista is manufactured by Centurion Laboratories Pvt Ltd. Aurochem Pharmaceuticals Pvt Ltd is based in India with multiple selling offices throughout the world, giving pharmaceutical products internationally. The company’s specialization is the manufacture of generic medications, which the organization is certified according to ISO 9000:2001 patterns.
Results of vidalista Tadalafil on Erectile Dysfunction in Men with Diabetes
Men with type 1 or type 2 diabetes and at least a 3-month history of ED were randomly assigned to one of three groups: tadalafil 20 mg, or tadalafil 60mg. 20 mg taken up to once every day for 12 weeks. Differences from baseline in mean rates on the erectile function field of the International Index of Erectile Function (IIEF) and differences from baseline in the balance of “yes” responses to question 2, “Were you ready to penetrate?,” and 3, “Were you ready to perform intercourse
Do vardenafil and tadalafil vidalista 60 have advantages?
Erectile dysfunction (ED) changes up to 50% of men within the ages of 40 and 70. Sildenafil, vardenafil, and tadalista 40 tadalafil have all been revealed to be likewise effective in managing men with ED of various etiologies, having related unfavorable effects profiles, and improving quality-of-life by equal amounts. As these phosphodiesterase 5 (PDE5) inhibitors all enhance the hypotensive results of nitrates, they are not proper for use in sufferers taking nitrates for the treatment of ischaemic heart disease.
All three inhibitors must be applied with caution in patients receiving α1-adrenoceptors competitors for benign prostatic hyperplasia. Although nonarteritic anterior ischaemic neuropathy has been described in some users of the PDE5 inhibitors, there is no convincing proof that PDE5 inhibitors cause this unique effect.
Over fildena sildenafil in the treatment of erectile dysfunction?
vidalista 40 Tadalafil has a longer half-life than sildenafil or vardenafil and a more prolonged activity duration than sildenafil and vardenafil. Most preference searches have shown vidalista tadalafil to be favored, but there are important limitations to some of these problems. One treatment program gives each patient a short- and long-acting factor and for people to decide their choice.
What is a reliable dosage of Vidalista?
The protection of tadalafil dose is managed individually by the attending doctor, andrologist, sexologist, urologist, or any other healthcare professional – a choice that is based on the patient’s general status of health, the appearance of comorbidity states, the degree of an erectile problem provided by the subject, response towards the body, sensitivity towards tadalista tadalafil, and other factors as decided by the doctor.
The first doses of Vidalista range between 10mg and 20mg; it is suggested to use the more under dosage color pills at the beginning of the treatment on several individual events before moving up the dose towards Vidalista 40 mg or Vidalista 60 mg. The improvement in health goods is not achieved with the rise in the dose in patients with a sufficient response towards lower doses of tadalafil.
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domain: medical


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Trading in financial markets promised excitement, financial freedom, and the allure of making it big. However, my reality has been quite different. I’ve been a loss-making trader during my earlier days, and I want to share my story to shed light on the harsh realities that many traders face.
The Early Optimism:
Like many newcomers to the trading world, I began with high hopes and dreams of financial success. Armed with a basic understanding of charts and indicators, I thought I was ready to conquer the markets. The initial wins fueled my optimism, and I believed that I had a natural knack for trading.
The First Signs of Trouble:
It didn’t take long for the first signs of trouble to appear. As I dived deeper into the world of trading, I quickly realized that there was so much more to it than I had initially thought. The market’s unpredictability and the psychological toll it takes on traders became evident as my losses piled up.
Overtrading and Emotional Rollercoaster:
One of my biggest mistakes was overtrading. Fueled by the desire to recoup my losses, I often found myself making impulsive trades without proper analysis. Emotions like fear and greed played a significant role in my decision-making, leading to more losses than gains. It was a never-ending rollercoaster of emotions, from euphoria after a win to despair after a loss.
Lack of Proper Risk Management:
Another critical aspect I failed to grasp initially was risk management. I didn’t set stop-loss orders, and I often traded with larger positions than I should have. This lack of discipline only exacerbated my losses, and I found myself in a cycle of chasing the market and hoping for a miracle.
The Costly Learning Curve:
Trading, I soon realized, is not a get-rich-quick scheme. It’s a craft that requires discipline, knowledge, and a deep understanding of risk. I invested both time and money into learning from my mistakes, attending trading courses, reading books, and seeking advice from experienced traders. But the learning curve was steep, and losses continued to mount.
Seeking Professional Help:
As my losses became more significant, I realized that I needed professional guidance. I sought help from trading mentors and psychologists to address my emotional struggles. While this helped me gain some control over my emotions, it didn’t magically turn my losses into profits.
Being a loss-making trader has been a humbling and challenging experience. It’s a path filled with frustration, self-doubt, and financial setbacks. However, it’s also been a valuable learning experience that has taught me important life lessons about discipline, patience, and perseverance.
I want to emphasize that trading is not for everyone. It requires a deep commitment and an understanding of the risks involved. If you’re considering entering the world of trading, my advice is to approach it with caution, be prepared for losses, and never stop learning from your mistakes.
In the end, trading is not just about making money; it’s about self-discovery and personal growth. It’s about understanding your own strengths and weaknesses

domain: finance


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MONTGOMERY VILLAGE, Md. (WDVM) — Detectives from the Montgomery County Police Department need your help in identifying a suspect who robbed a Metro PCS cell phone store in Montgomery Village.
Police say it happened on November 6 and have released a surveillance video of the suspect shown entering the store on the 9900 block of Montgomery Village Avenue. The suspect approached the employee who was working behind the counter, with a knife. The suspect then threatened the employee and demanded cash from the register before running off.
“Were not sure from the video if the suspect was wearing a mask or not, it’s kind of hard to tell from the video so were just asking if anybody may have been in the area and has seen anything or may recognize the clothing or recognize the suspects movements to please give our detectives a call,” said Rick Goodale, Montgomery County Police Department.
The department’s major crimes division contact 240-773-5100.


RTCA Tennis At State
Courtesy of RTCA
Robert Toombs Christian Academy's tennis teams ended their season last Tuesday in Macon at the GISA Team Tennis Finals. Both the Varsity Boys and Girls teams competed and were one of five schools competing for the State title. Overall on the season, both girls and boys finished GISA 2-AA Region Runners-Up with the boy’s doubles team of Jackson Newton (Sr.) and Tucker Heath (Jr.) 1st in the Region.
Head Coach Glen Birkheimer had this to say about this year’s season, “There was a lot of growth from the start of the season to now from all players. We will be losing four seniors from our team, but we have a solid group that is ready to move up and fill in those spots next year. I am proud of how all of our players improved on the court this year and look forward to seeing even more growth from them in future seasons.”


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With such a wide selection of great replacement Vapor Canister Filter parts for your GMC online, you can stop taking trips to the dealership and get parts to fix your ride fast, easy, and for less money at www.carpartsdiscount.com. Since our staff of sales and customer support professionals are both knowledgeable and courteous, CarPartsDiscount.com has the expertise to make it your last stop online for the best replacement Vapor Canister Filter parts. Is there any reason to pay double or triple the prices when we have OEM and quality replacement parts at a fraction of the price for your GMC? To find the applicable Vapor Canister Filter parts for GMC C1500, C1500 Suburban, C2500, C2500 Suburban, C3500, Envoy, Envoy XL, G25, G35, Jimmy, K1500, K1500 Suburban, K2500, K2500 Suburban, K3500, Savana 1500, Savana 2500, Savana 3500, Sierra 1500, Sierra 1500 HD, Sierra 2500, Sierra 2500 HD, Sierra 3500, Sierra 3500 HD, Sonoma, Yukon, Yukon XL 1500, Yukon XL 2500 and more, pick your model from the list below.


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Timeless Treasures. GAIL – CD8895. Black.
These lovely mini dinosaurs by Gail Cadden for Timeless Treasures are part of the ‘Small World’ collection – perfect for patchwork, quilting, home decor and dressmaking.
100% Cotton. 112cm wide.
Please select 0.25 for a fat quarter.
Out of stock


Shopify is the leading cloud-based, multi-channel commerce platform designed for small and medium-sized businesses. It includes a huge selection of tools for anyone looking to start an eCommerce business.
Loyverse is a POS solution that uses a single dashboard to allow bars, restaurants, retail stores, cafes, and other businesses to check stock levels, print barcode labels, issue receipts, visualize sales metrics, and more.
Want to explore Shopify + Loyverse quick connects for faster integration? Here’s our list of the best Shopify + Loyverse quick connects.Explore quick connects
Looking for the Loyverse Alternatives? Here is the list of top Loyverse Alternatives
It's easy to connect Shopify + Loyverse without coding knowledge. Start creating your own business flow.
Triggers when a new entry is added to a blog in your Shopify store.
Triggers whenever a order is "cancelled" (with line item support).
Triggers when a new customer is added to your Shopify account.
Triggers when a new purchase is made (only open orders) (with line item support).
Triggers when a new purchase is made (of any order status).
Triggers whenever a new purchase is "paid". You can choose a different order status like pending or refunded (with line item support).
Triggers when a new product is added to your Shopify store.
Triggers when an order is updated (with line item support).
Updates existing customer
Trigger when a new customer is added
Triggers when a new employee is created
Triggers when inventory levels change.
Triggers when a new item is created
Triggers when a new receipt is added
Triggers when a new store is created
Triggers when a new tax is created
Creates a custom collection.
Creates a new customer.
Creates a new order (with line item support).
Creates a new product.
Update a existing order.
Create a customer.
Creates an Item
Creates a new receipt.
Creates a new customer or updates an existing one.
Edit Inventory Levels.
Gets a single item by ID
Updates a Single Item.
Shopify is a leading eCommerce platform for merchants and developers, powering more than 600,000 businesses in 150 different countries to date. It offers an easy-to-use, feature-rich spution for online stores and provides powerful apps and tops that help businesses process payments and integrate with social media sites. Shopify helps to get more traffic, manage inventory, run promotions, handle shipping and more. The best part about Shopify is it can be used by both small businesses and large ones.
Loyverse is the first pure-play, full-service, white label eCommerce spution provider in China. Loyverse provides its customers with white-labelled sputions for mobile commerce (m-commerce), which means the eCommerce system’s brand is hidden from the consumer. This is different from other eCommerce providers’ spution, where the brands are displayed prominently to consumers. Loyverse also offers a social networking service for its customers. This service allows consumers to create their own virtual storefront and sell products on social networking sites such as Weibo and WeChat.
Shopify’s integration with Loyverse will allow merchants to run their online stores using Shopify’s technpogy and Loyverse’s social networking services. This will reduce the burden on merchants by allowing them to focus on what they do best – selling products. It will also allow them to use Loyverse’s social networking services to attract new customers. This will allow merchants to not only create a mini-version of their online store on social networking sites but also attract potential customers through this free channel. In short, it will enable them to market their products through a different channel and potentially increase sales.
Merchants will have an added advantage of having a well-known brand to market their products through. Loyverse already has over 100 million registered users and has attracted some big brands such as Apple, Nike and Samsung. With this integration, merchants will also be able to add these big brands’ products to their virtual storefronts on social networking sites. This will again help them increase sales as it will allow them to tap into these big brands’ loyal fan bases. Additionally, this integration will benefit both companies invpved as it will allow them to expand their user bases. Merchants who are not familiar with social networking can now create mini-versions of their online stores on social networking sites. They can also benefit from the existing social network users by attracting users through their mini-online stores and converting them into paying customers. For example, if a merchant wanted to sell on Facebook but was unfamiliar with the site, he would now be able to create his own mini-store on Facebook that is powered by Loyverse. This would allow him to easily sell his products without having to learn about Facebook’s user interface or its processes. More importantly, it would allow him to tap into Facebook’s existing user base of over 1 billion people. Therefore, both merchants and Loyverse would be able to gain new customers through this integration, resulting in increased sales for both companies.
In conclusion, merchants can benefit from the new integration between Shopify and Loyverse as it will allow them to market their products through a different channel which could result in increased sales due to new customer acquisition from this free channel. Since both parties invpved stand to gain from this integration, this deal should be mutually beneficial for all parties invpved and should be beneficial for sharehpders of both companies due to increased sales vpume.
The process to integrate Shopify and Loyverse may seem complicated and intimidating. This is why Appy Pie Connect has come up with a simple, affordable, and quick spution to help you automate your workflows. Click on the button below to begin.
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|Birth name||Justin Wayne Tubb|
|Born||August 20, 1935|
San Antonio, Texas
|Died||January 24, 1998 (aged 62)|
Goodlettsville, Tennessee , U.S.
|Labels||Decca, Groove, RCA|
|Associated acts||Ernest Tubb, Goldie Hill, Lorene Mann|
Justin Wayne Tubb (August 20, 1935 – January 24, 1998) was an American country music singer and songwriter. Born in San Antonio, Texas, he was the oldest son of country singer Ernest Tubb, known for popular songs like "Walking the Floor Over You".
By 1954 Tubb made it on the country chart with two duets with Goldie Hill—("Looking Back to See" and "Sure Fire Kisses"). A year later, at age 20, he was made a member of the Grand Ole Opry. Tubb had a few recordings of his own that enjoyed success, including "I Gotta Go Get My Baby" and "Take a Letter Miss Gray", but he was more successful as a songwriter. He penned many hit songs for other performers, including "Keeping Up with the Joneses", "Love Is No Excuse", and "Lonesome 7-7203", a hit for Hawkshaw Hawkins. Ultimately, six of his songs won awards. In the late 1950s he roomed with a young, up-and-coming songwriter named Roger Miller.
During the 1960s, Tubb worked with his father on various business projects. Toward the end of his own life, he completed an album of duets with his father, using recordings Ernest had made before his death. The album, Just You and Me Daddy (1999), was released after Justin Tubb died in Nashville on January 24, 1998. He was survived by his wife, Carolyn McPherson Tubb.
Both of his sons (two of Ernest's grandsons)—Cary Tubb (died November 27, 2008, survived by older son Bryce and younger son Codee) and his younger brother Zachary Tubb—became musicians. Cary performed around the U.S. and in England. Zachary has released one album.
|1954||"Looking Back to See" (with Goldie Hill)||4|
|1955||"Sure Fire Kisses" (with Goldie Hill)||11|
|"I Gotta Go Get My Baby"||8|
|1963||"Take a Letter, Miss Gray"||6|
|1965||"Hurry, Mr. Peters" (with Lorene Mann)||23|
|1966||"We've Gone Too Far, Again" (with Lorene Mann)||44|
|1967||"But Wait There's More"||63|
|This article about a country musician from the United States is a stub. You can help Wikipedia by expanding it.|


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Thyrotropin-releasing hormone (TRH) and its receptor subtype TRH receptor-1 (TRHR1) are found in pancreatic β-cells, and it has been shown that TRH might have potential for autocrine/paracrine regulation through the TRHR1 receptor. In this paper, TRHR1 is studied to find whether it can initiate multiple signal transduction pathways to activate the epidermal growth factor (EGF) receptor in pancreatic β-cells. By initiating TRHR1 G protein-coupled receptor (GPCR) and dissociated αβγ-complex, TRH (200 nM) activates tyrosine residues at Tyr845 (a known target for Src) and Tyr1068 in the EGF receptor complex of an immortalized mouse β-cell line, βTC-6. Through manipulating the activation of Src, PKC, and heparin-binding EGF-like growth factor (HB-EGF), with corresponding individual inhibitors and activators, multiple signal transduction pathways linking TRH to EGF receptors in βTC-6 cell line have been revealed. The pathways include the activation of Src kinase and the release of HB-EGF as a consequence of matrix metalloproteinase (MMP)-3 activation. Alternatively, TRH inhibited PKC activity by reducing the EGF receptor serine/threonine phosphorylation, thereby enhancing tyrosine phosphorylation. TRH receptor activation of Src may have a central role in mediating the effects of TRH on the EGF receptor. The activation of the EGF receptor by TRH in multiple circumstances may have important implications for pancreatic β-cell biology.
- heparin-binding epidermal growth factor-like growth factor
- protein kinase C
- G protein
- signal transduction
type 1 and type 2 diabetes both result from an inadequate amount of functioning β-cells, even though type 2 diabetes is characterized by insulin resistance (23). Unveiling the mechanism of growth regulation in β-cells has been an issue of great interest in both the clinical and experimental arenas. Pancreatic β-cells have been characterized as part of the neuronal diathesis, possessing various neuronal derivative peptides and hormones that relate them closely with other neuronal derivatives, sharing a developmental process similar to the cells in the nervous system (19). Thyrotropin-releasing hormone (TRH) (1), first characterized and extensively studied as a hypothalamic factor with a key role in the thyroid axis, has been shown to be synthesized in the pancreas (5, 22) but not strictly limited to the central nervous system (12, 14, 38). Although TRH has been shown to be a neurotrophic factor in protecting neuronal function, aside from regulating thyroid hormone function, the primary role of TRH in pancreas is unclear (29). TRH receptor-1 (TRHR1) was found in the mouse pancreas and HIT-T15 cells (a hamster-immortalized β-cell line). TRHR1 activated by physiological levels of TRH modulates intracellular calcium (40). The TRH knockout mouse model (39) developed hypothyroidism, which could be reversed by thyroid hormone treatment. These animals also developed hyperglycemia; the diabetic state could not be prevented or reversed by treatment with thyroid hormone and was thus attributed to the loss of TRH's effects on β-cells rather than the indirect effects of thyroid deficiency. The impaired insulin secretion in response to glucose from these β-cells could be the cause of hyperglycemia. The lack of morphological changes reported in the pancreas of these mice suggests pancreatic β-cell dysfunction.
TRH has been reported to stimulate TRHR1 and dissociate the G protein-coupled receptor (GPCR) complex, activating protein kinase C (PKC) (6) and mitogen-activated protein kinase (MAPK) (6) in both a PKC-dependent and a PKC-independent manner in neuronal cell lines (34). These effects may involve activation of tyrosine kinase, which leads to the activation of Ras and MAPK cascade. The signaling pathways initiating from G protein-coupled TRH receptor in activating MAPK may overlap with the receptor tyrosine kinases activating the Ras-MAPK cascade (25, 26).
There is evidence that TRH and EGF have overlapping activities (2) that lead to the stimulation of tyrosine phosphorylation of EGF receptors in GH3 cells, a pituitary cell line (37). TRH-induced EGF receptor phosphorylation led to the recruitment of adapter proteins Grb2 and Shc in GH3 cells. TRH activates EGF receptors in pancreatic β-cells, which may play a role in β-cell development because EGF receptor expression was found to have a high activation level during the embryonic developmental period in the pancreas (5, 9).
The hypothesis of whether TRH activates EGF receptors in β-cells through multiple pathways is evaluated in this study. Our findings indicate that TRH transactivates EGF receptors through several intra- and extracellular pathways, which are distinct from pituitary-derived cell lines. These diversities might imply the significance and dependability of the biological role of TRH in pancreatic β-cells under varying physiological situations.
The mouse βTC-6 and hamster HIT-T15 pancreatic β-cell lines were purchased from American Type Culture Collection (Manassas, VA). Cell culture medium and all supplements were from GIBCO Life Technologies (Gaithersburg, MD). Anti-EGF receptor phosphospecific antibodies (pY1068 and pY845) and anti-Src pan- and phosphospecific antibodies were purchased from BioSource International (Camarillo, CA). Anti-EGF receptor antibody sc1005, anti-actin antibody, anti-phosphotyrosine antibody (pY20), anti-phosphothreonine antibody, and horseradish peroxidase (HRP)-conjugated anti-rabbit IgG second antibody were from Santa Cruz Biotechnology (Santa Cruz, CA). The kit for G protein β-subunit assay and 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2) were from Calbiochem-Novabiochem (San Diego, CA). Anti-HB-EGF polyclonal antibody was from Oncogene Research Products (7), anti-matrix metalloproteinase (MMP)-3 antibody from Chemicon International (Temecula, CA), and anti-phospho-PKC (1) antibody from Cell Signaling Technology (Beverly, MA). Bisindolylmaleimide (Bis) and 4-α-phorbol 12-myristate 13 acetate (PMA) (7) were from Sigma (St. Louis, MO).
Cells were grown in Dulbecco's modified Eagle's medium supplemented with 15% fetal bovine serum for βTC-6 at 37°C in a humidified 5% CO2 atmosphere. Cell monolayer (passages 10–35) at 80–90% confluence in cell culture dishes was used for the experiments. The medium was changed to serum-free medium ≤30 h before hormone stimulation (no 15% FBS added).
As reported previously (20), briefly, after hormone treatment with or without various inhibitors, cells were washed once with ice-cold Hanks' balanced salt solution and lysed in lysis buffer containing phosphatase inhibitors (50 mM Tris·HCl, pH 7.5, 0.2% Sigma Phosphatase Inhibitor Cocktail II, 0.1% Nonidet P-40). Cell lysates were shaken on ice for 2 h and centrifuged at 12,000 rpm for 30 min at 4°C. Protein content in the supernatants was determined with a spectrophotometric protein assay kit (Pierce, Rockford, IL). Cell extracts were resolved on polyacrylamide mini gels (typically 50 μg/lane). After transfer to nitrocellulose, membranes were blocked overnight at 4°C in a solution of 5% milk and 0.5% Tween 20 in TBS and incubated with specific antibodies followed by HRP-conjugated second antibody. After a wash, protein bands were identified by enhanced chemiluminescence (Super Signal Pierce) and BioMax MS highly sensitive X-ray film (Eastman Kodak, Rochester, NY).
RT-PCR and direct sequencing.
TRIzol reagent (Invitrogen, Carlsbad, CA) was used to prepare total RNA from cultured βTC-6 cells, and then cDNA was made using M-MLV reverse transcriptase (Promega, Madison, WI). As described previously (41), cDNA (20 μl) was produced from total RNA (3 μl), and cDNA (1.25 μl) was subjected to 30 cycles of PCR using the following primers: β-actin sense, 5′-TGA TGA CGC AGA TAA TGT TTG-3′; β-actin antisense, ATG ATG GAG TTG AGG TGG TC-3′; TRHR1 sense, 5′-GCC CTC GAG TAC CAG GTG GTT ACC ATC-3′; TRHR1 antisense, 5′-AGT AGT AGT TCC TGG AGA TCT TGT AGC CA-3′. cDNA prepared from rat pituitary was served as positive control. Each cycle consisted of 94°C for 1 min, 70°C for 2 min, and 72°C for 2 min. The PCR product was run on 2% agarose gel stained with ethidium bromide and then photographed. The band was extracted and reconstituted in Tris-EDTA buffer for direct sequencing by the Taq DNA polymerase cycle sequence method as described before (42). Briefly, the sense primer that was used for RT-PCR was used as a primer for the sequencing. Each sequencing cycle consisted of 15 s at 94°C, 45 s at 64°C, and 60 s at 70°C. After 30 cycles of the reaction, alkaline-heat denatured samples were loaded onto the sequencing gel. Analysis was performed using automated DNA sequencer (model ABI PRISM 377; PerkinElmer, Foster City, CA) in the Brown University Automated DNA Sequencing Facility.
Cell lysates were mixed with agarose-conjugated antibody and incubated overnight at 4°C with gentle rotation. The lysate-antibody mixture was washed three times with radioimmunoprecipitation assay buffer (20 mM Tris·HCl, pH 7.4, 0.1% SDS, 1% Triton X-100, 1% sodium deoxycholate). Pellets were dissolved in 50 μl 2× SDS protein sample buffer that was cleared by centrifugation, run on polyacrylamide gels of appropriate concentration, transferred to nitrocellulose, and analyzed by the Western blotting procedure described above.
Densitometry analysis was performed using Scion Image for Windows (Scion, Frederick, MD).
All data are presented as means ± SE and were analyzed by analysis of variance followed by Student's t-test unless otherwise indicated. Sigma Plot (SPSS, Chicago, IL) was used to draw charts. All data represent the results of three independent experiments unless otherwise indicated.
Time course of two EGF receptor phosphorylation residues in response to EGF and TRH.
In an initial series of experiments, the effects of TRH at a concentration expected to yield the maximum TRH receptor binding (18) on EGF receptor tyrosine phosphorylation was studied in three different cultured β-cell lines HIT-T15, βTC-6, and INS-1, derived from rats (a gift from Dr. Claes Wollheim, Centre Médical Universitaire, Geneva, Switzerland). Before this study, all three cell lines were shown to tolerate incubation in serum-free medium for 30 h without vacuolization or other morphological changes that were evident by phase-contrast microscopy (data not shown). After incubation in serum-free medium for 16 h, EGF receptor tyrosine phosphorylation was increased after the addition of TRH for 10 min (determined by immunoprecipitation with EGF receptor antibody and sequential immunoblotting with phosphorylation antibodies). Identification of the EGF receptor was performed by stripping and reblotting the membranes with EGF receptor antibody (6). The 175-kD band stimulated by TRH was confirmed as the EGF receptor. Although TRH increased EGF receptor tyrosine phosphorylation in each β-cell line, it was weaker than achieved with EGF itself. The greatest EGF receptor phosphorylation in response to TRH was the βTC-6 cell line, which was generated from three individual experiments (data not shown). Thus the βTC-6 cell line was selected in this study.
Because there are various domains of EGF receptor phosphorylation in response to different stimulus, the use of the specific antibody that corresponds to EGF receptor phosphorylation sites would be a useful tool in pinpointing the specific domain of the EGF receptor in response to TRH. We are able to show that TRH activates phosphorylation of the EGF receptor cytoplasmic domain Tyr1068 at 10 min in βTC-6, HIT-T15, and INS-1 cells using anti-pY1068 antibody (26).
Two tyrosine residues (pY1068 and pY845) of the EGF receptor that responded to EGF and TRH were evaluated by immunoblotting. This was performed using corresponding phosphorylated specific antibodies for various times. The results indicate that maximum EGF receptor tyrosine phosphorylation occurred within 2 min and lasted until at least 30 min for the Tyr1068 (Fig. 1A) and the Tyr845 (Fig. 1B). For Tyr1068, the maximum EGF receptor tyrosine phosphorylation stimulated by TRH occurred at 10 min and lasted until 30 min (Fig. 2A). For Tyr845, although phosphorylation was weaker than for Tyr1068, it reached a maximum at 5 min and lasted longer (Fig. 2B). These results show that there exists a delay for the EGF receptor in response to TRH, as well as a weaker signal, compared with the response to EGF.
TRHR1 gene expression in βTC-6 cells.
The delay in the EGF receptor phosphorylation response to TRH compared with EGF indicates that there are several different mechanisms between TRH and EGF for EGF receptor activation. It is unclear whether TRH phosphorylates the EGF receptor through TRHR1 (21) or -R2 (37). TRHR1 has been found in the mouse pancreas, but no references were reported as to whether the TRH receptor is present in mouse β-cells. To verify the expression of the TRH receptor in βTC cells, we prepared cDNA from the βTC cell line and performed RT-PCR by using specific primer pairs of TRHR1 and -R2 genes. As shown in Fig. 3A, only TRHR1 showed one single distinct band of expected size (507 bp by RT-PCR) in βTC-6 cells as well as in rat pituitary tissue. No expression of TRHR2 was detected. The band detected from PCR was a direct sequence, showing 98% homology (469/477) to the mouse TRHR1 sequence from the National Center for Biotechnology Information database (NM 013696) (Fig. 3B).
TRH enhanced G protein βγ subunit dissociation.
The TRH receptor is a G protein-coupled binding receptor (2). TRH may activate the EGF receptor phosphorylation through its own receptor, a G-protein complex αβγ activation. A rabbit anti-G protein β-subunit internal sequence (127–139) was used to detect the βγ subunit dissociated from the TRH-activated αβγ-complex. The antibody can detect the βγ subunit in concentrations as low as 3.125 ng/ml. The results indicate that TRH stimulates dissociation of βγ subunits from the αβγ complex in 5–15 min (Fig. 4). This result is consistent with the TRH activation of its own GPCRs in βTC-6 cells (32).
TRH-induced EGF receptor phosphorylation by Src activation.
Tyr845 in the EGF receptor is a known Src phosphorylation target (31). TRH should activate Src phosphorylation if Src is involved in the TRH activation of EGF receptor phosphorylation. The stimulation and inhibition at Tyr845 by TRH and PP2, an Src family kinase inhibitor, would provide evidence supporting Src as a mediator in the TRH activation of EGF receptor phosphorylation. As expected, TRH stimulates Src phosphorylation (Fig. 5A) as well as EGF receptor Tyr845 phosphorylation (Fig. 5B, top right) in βTC-6 cells. PP2 blocked TRH-stimulated phosphorylation of Src (Fig. 5A) and Tyr845 (Fig. 5B, top). However, no effects of PP2 on TRH-stimulated Tyr1068 phosphorylation (Fig. 5B, bottom right) were observed.
Activation of Src-PKC pathway is involved in the TRH mediation of EGF receptor phosphorylation.
On the basis of data shown in Fig. 5, the Src inhibitor PP2 (50 μM) reduced the effect of TRH on EGF receptor Tyr845. The reduced effect at Tyr1068 (Fig. 5B) suggests that multiple mechanisms are involved. We suspect there is a PKC mechanism involved between TRH and EGF receptor activation. Suppression of Src by PP2 significantly enhances TRH during PKC phosphorylation (Fig. 6A), which indicates the Src inhibition of PKC activation, presenting evidence for PKC involvement. We propose that Src-PKC activation plays an important role in EGF receptor phosphorylation. When combining PP2 (50 μM), Bis (10 μM, a PKC inhibitor), and PMA (10ng/ml, a PKC stimulator) with TRH (18) in βTC-6 cell lines, PP2 suppressed TRH-induced EGF receptor phosphorylation at Tyr845, Bis enhanced TRH activation of EGF receptor tyrosine phosphorylation, and PMA (10 ng/ml) inhibited EGF receptor phosphorylation (Fig. 6B). Furthermore, by using anti-phosphorylated threonine antibody in an immunoprecipitation study, both PP2 and PMA were enhanced, but Bis significantly inhibited threonine phosphorylation of the EGF receptor (Fig. 6C). This indicates that there is Src-PKC activating threonine phosphorylation, which indirectly inhibits EGF receptor tyrosine phosphorylation in the TRH regulation of the EGF receptor.
The role of HB-EGF in TRH activation of EGF receptor.
HB-EGF binds to the cell surface heparin sulphate proteoglycan matrix and is proteolytically converted to a soluble form that can bind to the EGF receptor (30). Several intrinsic proteinases cleave the cell surface binding of HB-EGF, including MMP-3 (32, 35). HB-EGF activation induced by GPCR signal transduction (13) suggests the possibility that HB-EGF may be involved in the TRH cross talk with the EGF receptor. We explored this issue by using a specific anti-HB-EGF antibody to block the release of soluble HB-EGF by TRH in culture medium. The antibody dramatically suppressed the activity of TRH on EGF receptor phosphorylation (32). Meanwhile, TRH increased the amount of MMP-3, which may cleave the outer cell membrane portion of HB-EGF off into the culture medium (Fig. 7). The inhibition of Src by PP2 significantly neutralized this effect (Fig. 8).
In this paper, it has been demonstrated that TRH induced EGF receptor tyrosine phosphorylation by activating intracellular signal transductions in pancreatic β-cell lines (Fig. 1–2). The concentrations of TRH (200 nM) and EGF (20 nM) were selected according to our preliminary dose response studies (data not shown) and those of other investigators (17). The dosages of TRH and EGF used in this project and the cells' response to the stimulation were considered physiological. Multiple steps of intervening processes involved in EGF receptor phosphorylation in response to TRH resulting in the delayed and prolonged EGF receptor activation suggest the unique biological role of TRH regulation of EGF receptor function in β-cells (Fig. 3).
TRHR1 expression in β-cell lines (βTC-6 cells derived from mice; Fig. 3) and in the rat pancreas (21) are consistent with previous reports (40). A high-affinity (Kd) value for TRHR1 (determined by radioreceptor assay with H3-Met-TRH) (40) indicated that TRHR1 has a significant function in pancreatic β-cells and may be involved in the mechanisms related to paracrine and/or autocrine effects. TRH is not able to bind to the EGF receptor directly. TRH initiated EGF receptor phosphorylation, which may be through the TRHR1 receptor paracrine effect in β-cells. A higher-affinity MT-TRH (TRH analog) induced stronger EGF receptor phosphorylation than native TRH (21), which fits the notion that the TRH stimulation of EGF phosphorylation depends on TRH receptor-activation. TRH binds to its receptor, causing dissociation of the α- and βγ-G protein subunit and thus triggering signal cascades after GPCR activation (Fig. 4) (2).
Cytoplasmic tyrosine kinases may play a role as downstream components of GPCR's pathways (2, 10, 11). Recent studies have indicated that several types of GPCR activation and inhibitive regulation of the Src family kinase (2) suggest that the Src family plays a critical role in GPCR growth factor receptor's transactivation (15).
Many growth factors that signal via tyrosine phosphorylation mechanisms such as EGF affect islet development and maturation (33). Transient upregulation of both EGF and EGF receptors has been observed during islet proliferation and regeneration (3). In pancreatic β-cells, our studies show that there are multiple pathways involved in TRH activation of EGF receptor phosphorylation distinctly from pituitary cells (37). A series of our own experiments using the Src inhibitor PP2 verified the involvement of the tyrosine kinase in TRH-induced EGF receptor tyrosine phosphorylation. PP2 partially inhibits TRH-induced Src activation (Fig. 5A), indicating that Src is a critical link between TRH and EGF receptors in β-cells. This is similar to Src in vasopressin-mediated mitogenic signaling in intestinal epithelial cells (8). However, Src does not completely inhibit the effects of TRH on the EGF receptor, which suggests that there are other factors involved.
PKC has been found to activate TRH in the neuronal system, which regulates pituitary function (27, 34, 36). Expression of various PKC subtypes in pancreatic β-cells is involved in multiple functions from insulin secretion to cell differentiation (6, 17). However, the role of PKC in TRH stimulation of EGF receptor in β-cells is unclear. We found that PMA (a stimulator of PKC) suppresses TRH-induced EGF receptor tyrosine phosphorylation (Fig. 6B). The participation of PKC in TRH activation of EGF receptor phosphorylation is linked to Src activation, wheras the inhibition of Src enhances the reaction of PKC. Therefore, we proposed that Src can activate EGF receptor phosphorylation indirectly by suppressing PKC (Fig. 6B), which is known to initiate a serine/threonine phosphorylation, thus inhibiting the phosphorylation of the tyrosine residue in the EGF receptor (8). As expected, both PP2 and PMA induce threonine phosphorylation in the EGF receptor (Fig. 6C), consequently inhibiting tyrosine phosphorylation. Integrating all these findings, we propose that there is an Src-PKC pathway in the TRH activation of EGF receptor phosphorylation.
GPCR-EGF receptor transactivation through HB-EGF has been reported (4, 16, 28, 30). HB-EGF, a member of the EGF family, has the ability to bind to cell surface heparin sulphate proteoglycans; this prevents the immediate release of the growth factor and increases the local growth factor concentration within the cellular microenvironment (24). Previous reports (13, 30) implicate the involvement of HB-EGF in EGF receptor transactivation in GPCR's stimulation and HB-EGF-cleaving metalloproteinase, which is rapidly induced by GPCR-ligand interaction. HB-EGF binds to the cell surface heparin sulphate proteoglycan matrix and is proteolytically released into a soluble form that can bind to the EGF receptor (30). Several intrinsic proteinases cleave the cell surface binding of HB-EGF, including MMP-3 (32, 35). In this study, TRH-induced tyrosine phosphorylation of the EGF receptor is partially inhibited by neutralizing HB-EGF through the use of a specific antibody (Fig. 7). The stimulation of TRH in MMP-3 activation in βTC-6 cells was suppressed significantly by PP2 (Fig. 8), suggesting that TRH activation of the proteinase for MMP-3 may be through activation of Src. This mechanism may represent an alternate pathway for GPCR-EGF receptor transactivation. The use of immortalized cell lines in this study overcomes the replicative senescence of primary β-cell culture. However, the biological characteristics of immortalized cell lines may differ from normal β-cells. Therefore, caution should be used when extrapolating our results to normal β-cells.
In summary, the TRHR1 (but not the TRHR2) receptor found in β-cells supports receptor cross talk mechanisms for TRH-stimulated EGF receptor activation. TRH binds to its receptor, activating multiple pathways including 1) GPCR-dissociated αβγ-complex, 2) activation of the Src kinase resulting in phosphorylation of EGF receptor Tyr845, 3) release of HB-EGF as a consequence of MMP-3 activation, and 4) inhibition of PKC activity resulting in reducing inhibitory EGF receptor serine/threonine phosphorylation. Because the Src inhibitor PP2 blocks TRH-induced MMP-3 activation and PKC inhibition, TRH receptor activation of Src may play a central role in mediating the effects of TRH on the EGF receptor (Fig. 9). The TRH activation of EGF receptor phosphorylation indicates that TRH could regulate pancreatic β-cell development and maturation by mediating phosphorylation of the EGF receptor, leading to a model involving the peptide regulation of development and function in the pancreas.
This work was partially supported by the Roger Williams Hospital Research Foundation and the NIH Center of Biomedical Research Excellence program led by Dr. Peter Quesenberry.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2006 by American Physiological Society

domain: biology


text:
BWW Review: AN AMERICAN IN PARIS and Pittsburgh
With the fighting over and the French Tricolour waving high, Paris finds itself beginning to stand straight again after a battering war. Adam Hochberg (Etai Benson) and Jerry Mulligan (McGee Maddox), two former United States soldiers who fought in the war, stake their claim in the City of Lights in 1945, both for varying reasons. Add on top of this a beautiful young dancer who has caught the eyes of more than her dance instructors, and An American in Paris is born.
The show is unsurprisingly heavily focused on dancing, though not out of context; the premise follows Lise Dassin (Sara Esty), a young ballerina who finds herself the star of a new ballet commissioned by a rich American patroness, Milo Davenport (Emily Ferranti). The audience soon learns of a love rectangle that begins to form between Adam, Jerry, Henri, and Lise.
Adam narrates the show and is the pianist and composer of Lise's ballet, Jerry is the designer for Lise's piece, and Henri Baurel (Nick Spangler) is son of highly influential ballet patrons.
Ms. Ferranti and Mr. Spangler steal the show with their vocal abilities; resonating vibrato fills the space, while Mr. Maddox's dancing shows why he was cast in the lead role. Ms. Esty, who has been with the show since its inception, demonstrates her comfortability in the role as she moves across the stage with grace and ease. If you find yourself questioning the lack of dancing in the second act, just wait. George Gershwin's 17-minute musical suite "An American in Paris" will soon greet you.
Although the musical debuted in 2014, its origins can be traced far back into the twentieth century. The show follows a similar plot to the 1951 MGM Film of the same name and stars Pittsburgh-born Gene Kelly. With some dated material, the new stage version seems to unintentionally illuminate mid-twentieth century sexism with the helpless dancer, Lise, being overpowered by the dominant male archetype that is Jerry.
Still, the show received much critical acclaim. An American in Paris won the 2015 Tony Award for Best Scenic Design of a Musical, though I have to question the competition that year, based on what is presented in the touring version of the show. The design relies heavily on the use of projections and moving panels that can be projected onto. This concept makes for a nice appearance, sometimes, but it raises questions in my head as to whether or not these designs were used to lower production costs of this show. Surely, a show of this scale deserves the grandeur that comes along with an old-time MGM musical.
The true winner of this show was the orchestrations. With music and lyrics by George Gershwin and Ira Gershwin and orchestrations by Christopher Austin and Bill Elliott, it is no wonder the show garnered the 2015 Tony Award for Best Orchestrations. In addition, the show received two other Tony Awards (Choreography and Lighting Design) out of its whopping 12 Tony Award nominations.
An American in Paris strikes a balance between ballet and musical, between elaborate and tawdry, and between progress and tradition. At times these scales should have been tipped in one direction or another, but the nearly three-hour show that resulted is a nice night out in the steel city, of lights.
An American in Paris is presented as part of Pittsburgh CLO's 2017 Summer Season and the PNC Broadway in Pittsburgh 2016-2017 series.
To see or not to see score: 5/9; Approved Show
Photo Credit: Matthew Murphy


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There’s no denying that some of the dishes coming out of the UK’s Michelin-starred restaurants these days are like little edible works of art. Plonking a bit of gold leaf on some food just doesn’t cut it anymore; we live in a world of micro-herbs, dry ice, blowtorches and bespoke ceramics, all utilised to present a dish in the best possible way.
But there’s always the risk that in the quest for beauty, chefs can prune their dishes to such an extent that there’s hardly anything on the plate (remember the extremes of the Nouvelle Cuisine movement in the 1980s?), leaving diners wondering why they’ve forked out so much for something they can eat in two bites. The aesthetics of a dish are obviously important, but some would argue that if a plate of food doesn’t leave you satisfyingly full afterwards, it hasn’t done its job.
Of course, that’s not to say that giant plates of food are always slopped on the plate without any thought going into the presentation. But how important are looks? Do we eat with our eyes as much as our mouths? Some of the recipes over on Great Italian Chefs certainly prove presentation is at the very heart of some dishes.


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One in ten UK workers have paused their pension contributions during the Covid-19 pandemic with their absence from the defined contribution (DC) space bringing serious implications for the retirement landscape.
Canada Life surveyed 2,000 UK adults through August and find a further 13% had considered pausing contributions. The biggest reason (37%) cited among those who had was to use the money for essential...
Aviva Investors’ fully ESG-integrated ‘My Future Focus’ investment strategy has been adopted by the Aviva Master Trust as its standard default.
Phoenix Group will launch an ESG defined contribution (DC) default solution for pension fund clients of its Standard Life Assurance business and their scheme members.
Newton’s Curt Custard considers the investment outlook for 2021 and the implications for DC schemes
Master trusts’ investment strategies have grown and become more sophisticated over the last three years, but “growing pains” are hindering progress, according to the Defined Contribution Investment Forum (DCIF).
More than half of BlackRock’s flagship UK defined contribution (DC) default fund’s assets will be invested in ESG strategies by June 2021.


Generasi Biru: Difference between revisions
(→Chicken Pox: CE (remove trivia))
Slank has made a breakthrough in Indonesian music in the 90's. Before Slank, Indonesian music was dominated by the so-called 'pop cengeng' and Creative Pop genre. The various musical influences within Slank personnels has made a difference in their music. This difference was found out by a graphic designer, Boedi Soesatio, who was also a family friend of Indra Q. This was the man who land the deal to the band for the first three albums.
After the first three-album contract discontinued from Boedi Soesatio, Slank decided to produce the next album themselves. Slank tried to make another breakthrough by recording the album outside a recording studio. They use three units of [[ADAT]], a [[Super VHS]] format recording units owned by Indra Q, the keyboardist.
Six songs were recorded at '''Pondok Nurul''' a villa at Cipayung, West Java. Two songs were recorded at Bunda Emma's place at Cibubur, West Java. The rest was taken at their home base in Jalan Potlot. These recording process was drawn as sketch inside the album sleeve.<ref>Generasi Biru album sleeve</ref>


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DJ Tira, this year celebrates 21 years of being in the Mzansi music industry and the hitmaker himself has admitted that staying relevant for so long does, however, come at a price.
Following TNS’s emotional Instagram Live on Friday, where he begged for his life and alleged that there is a group by the name of ‘Durban United’ who are allegedly scheming for his demise.
The music producer went on to allege that there is also a WhatsApp group which consists of a lot of Durban artists who want to take all of his music. He reiterated that he did not know the group existed and that he is also not part of it.
Somehow, many people have come to the conclusion that the DJ Tira is the person who wants to see the Banomoya hitmaker down, with some insinuating that Tira is involved in the so-called “WhatsApp groups”.
Whatever he did to TNS, he must explain himself #DjTiramustfall
— THE SQUAD (@UnitySquadz) April 17, 2020
— Cheng musanda (@RotshidzwaChri1) April 17, 2020
— Bantu Bhungane💎 (@BantuPS) April 17, 2020
So tomorrow its #DJTiramustfall…😂
— PhistoMshini (@phisto_mshini) April 17, 2020
Taking to Twitter, DJ Tira shared a post from TNS from December 2019, in which the music producer praises Tira for helping him open his record label Tns Music Records when he was crying for help in Mzansi.
Tira captioned the post with a thinking face emoji that left many wondering what could be mean and the comment section definitely went wild with many conclusions.
— Thank You Mr DJ (@DJTira) April 17, 2020
On Friday, Makoya Bearings dropped a new single, Superhero featuring Naakmusiq and DJ Clock and in a separate post about the single, the DJ definitely let his feelings known about the allegations.
I guess being relevant for 21 Years comes at a price. Always being blamed for things you don’t know. But how do you do it Malume, how do you stay focused? I STAY BLIND TO THE BS ✌🏽#SuperHero in stores #Nguwe out in August my birthday month. Hello Ladiessssss 😁 pic.twitter.com/IcJdcP7yYk
— Thank You Mr DJ (@DJTira) April 18, 2020
Do you think fans are reaching with the allegations against Tira or is this just the price for success?


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For a lifetime of good health . . .
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Our team has served the women of Carteret County and the surrounding areas since 1977. Over the years, we’ve built a reputation for excellence in women’s medicine. Our board-certified women’s health specialists are committed to staying current with the latest advances and technology, so you can feel confident that you’re getting the highest level of care available. Today, we offer virtually every women’s health service you may need, including many in-office tests and treatments. At Carteret Ob-Gyn Associates, we believe that how you’re treated is just as important as the medical care we provide. Our physicians are easy to talk to and our entire staff is friendly and attentive to your needs. We are dedicated to providing the highest quality obstetrics and gynecology with warmth and compassion. Like the thousands of women who have placed their trust in us over the years, it’s a level of care you’re sure to appreciate.
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Better health for all your life stages. Call Carteret Ob-Gyn Associates at 252.247.4297 today to schedule your appointment. We look forward to caring for you! For your convenience, you can also fill out our online Request an Appointment form.


text:
Image 1 of 43
Mt. Fuji sunrise,
Sunrise at Hada Port on the Izu Peninsula, Mt. Fuji towers over the bay. The Torii Gate captures the morning sun. Torii Gate most commonly found at the entrance of a Shinto shrine, where it symbolically marks the transition from the profane to the sacred.
- © Daryl L. Hunter - The Hole Picture
- Image Size
- 5760x3840 / 6.8MB

domain: geography