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Archeologists have uncovered what is believed to be the world’s oldest erotic graffiti, and guess what? …It’s gay!
Dr. Andreas Vlachopoulos, a specialist in prehistoric archaeology, made the very sexy discovery on the Greek island of Astypalaia. The graffiti dates back to the 5th and 6th centuries B.C. and is described as “monumental in scale” and “tantalizingly clear” despite thousands of years of exposure to the erosive effects of the sun, wind, and sea.
“Few Greek islands have been properly explored or excavated,” Vlachopoulos to the Guardian. “These findings are testimony to why it is so important that they are.”
Two carvings have so far been discovered. Both are chiseled into slabs of dolomite limestone. The first features two penises beneath the name “Dion” and is believed to be from the 5th century B.C. The second is an inscription that reads: “Nikasitimos was here mounting Timiona.” It is believed to be from the 6th century B.C.
(Turns out gay men have been bragging about their bedroom conquests for longer than we ever imagined.)
“We know that in ancient Greece sexual desire between men was not a taboo,” Vlachopoulos said. “But this graffiti … is not just among the earliest ever discovered. By using the verb in the past continuous [tense], it clearly says that these two men were making love over a long period of time, emphasizing the sexual act in a way that is highly unusual in erotic artwork.”
Vlachopoulos says other rock art was found at the site, including carvings of oared ships, daggers, and spirals. But, honestly, we just care about the penises and men mounting one another.
Check out more erotic gay artwork from centuries ago below.
Niankhkhnum and Khnumhotep
In 1964, an Egyptian tomb from 2400 B.C. was discovered in the necropolis at Saqqara, Egypt. It belonged to Niankhkhnum and Khnumhotep, two men who had worked as royal manicurists in the palace of the king. The artwork decorating their tomb is believed to be some of the earliest portrayals of homosexual love, with pictures of the men holding hands, embracing, and even kissing.
Bi Yuan and Li Guiguan
This painting depicts Qing-dynasty scholar and bureaucrat Bi Yuan and his male lover Li Guiguan. Yuan was born in China in 1730. When he was still a struggling student, Bi Yuan met successful opera singer Li Guiguan. Li Guiguan supported Bi Yuan financially as he finished school and worked his way up in the government sector. The two men lived as a married couple for many years and were the basis for Chen Sen’s 1857 novel Precious Mirror for Ranking Flowers, the first gay novel in China.
These ancient Greek plates pretty much speak for themselves.
This ancient Roman coin, called a “spintria“, is from 22-37 A.D. and depicts a man with an erect penis lying on his belly while another man penetrates him behind. The two lovers stare passionately into one another’s eyes. Spintria were small bronze or brass tokens that typically featured sexy pictures and were used to pay prostitutes. We’re pretty sure a coin like this wouldn’t fly today.
Ancient phallus shaped “tool”
This 8-inch stone object was discovered in the famous Hohle Fels Cave in Swabian Alps in 2005. Scientists believe it is about 28,000 years old and may have been used as a “sex aide” during the Ice Age. Either that or a flint. You know, to start a fire. Or maybe both? You decide.
The Very Erotic Art of Pompeii
The eruption of Mount Vesuvius in 79 A.D. completely destroyed the Roman city of Pompeii. Residents were buried under 20 feet of ash and over time the ruins were preserved and turned to stone. That’s the story must of us know anyway. But few people know that underneath all that ash and dirt were loads of kinky erotic art featuring gay sex, straight sex, penises, threesomes, you name it. It was everywhere, which really isn’t all that surprising considering that Pompeii had a reputation for being a party town. (A prostitute there made three times more than the average laborer or worker in the city.) When the artwork was first discovered, people found it so scandalous that much of it was either destroyed or locked away in the National Museum of Naples, where it remained hidden from view for over 100 years. In 2000, the art was finally made viewable to the public, but minors must be accompanied by an adult.

domain: history


text:
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|ITV transmission date||17th April 1992 (Friday)|
|Story editor||Trevor Suthers|
|Story associates|| Graham Carlisle|
|Executive Producer||David Liddiment|
|Previous episode||15th April 1992|
|Next episode||20th April 1992|
Jim and Liz find that Andy has not slept on the sofa. Liz doesn't like the idea of him and Paula Maxwell sleeping together. Mike and Alma spend the night together. Rita urges Ted to find a specialist to talk about his tumour. He tells her that he's been to both Christie's and Guy's Hospital but no one can help him. She is distressed that he's going to die. He tells her that he wants to enjoy the rest of his life. Andy is worried what his parents will say about him sleeping with Paula. Ted explains to Rita how he feels about his illness. She tells him that she feels cheated; she thought she was going to be happy for the rest of her life but that was a trick. Liz and Jim tell Andy that they're disappointed in him. Liz feels that Paula can't have any self-respect. He apologises but assures them they took precautions. Mike announces his engagement in the Rovers.
- Rita Fairclough - Barbara Knox
- Gail Platt - Helen Worth
- Alma Sedgewick - Amanda Barrie
- Mike Baldwin - Johnny Briggs
- Mavis Wilton - Thelma Barlow
- Derek Wilton - Peter Baldwin
- Liz McDonald - Beverley Callard
- Jim McDonald - Charles Lawson
- Alec Gilroy - Roy Barraclough
- Betty Turpin - Betty Driver
- Percy Sugden - Bill Waddington
- Raquel Wolstenhulme - Sarah Lancashire
- Audrey Roberts - Sue Nicholls
- Andy McDonald - Nicholas Cochrane
- Martin Platt - Sean Wilson
- Des Barnes - Philip Middlemiss
- Victoria Arden - Chloe Newsome
- Phyllis Pearce - Jill Summers
- Alf Roberts - Bryan Mosley (Uncredited)
- Coronation Street exterior
- Rovers Return Inn - Public
- 10a Coronation Street - Living room
- 11 Coronation Street - Back room/kitchen and hallway
- The Kabin
- Jim's Cafe
- No. 4 Montreal House, Weatherfield Quays - Living room/kitchen
- TV Times synopsis: The champagne flows at the Rovers, but Rita feels she has nothing to celebrate. Liz and Jim find themselves facing a new challenge laid down by their children.
- Viewing Figures: UK broadcast - 16,320,000 viewers (11th place - combined figure including repeat).
|April 1992 episodes|
|Wed 1st • Fri 3rd • Mon 6th • Wed 8th • Fri 10th • Mon 13th • Wed 15th
Fri 17th • Mon 20th • Wed 22nd • Fri 24th • Mon 27th • Wed 29th

domain: entertainment


9 never Ways to ensure you fail an MOT
Your bike’s MOT test doesn’t have to be worse than a trip to the dentist
1 Is the chassis sweet?
Inspect your bike’s chassis well in advance of the MOT date. Check for clunks, creaks, loose parts and wobbles. Notchy bearings, loose bushes are easy to check for and you’ll feel them when you ride – if they’re shot, or on their way out, your MOT tester will find them, so don’t bank on getting away with it for another year. Better to get them fixed now than to have to rush the job to meet an MOT re-test.
2 Chains, sprockets and belts
If these advice pages haven’t beaten you in to taking proper care of your chain, now’s definitely the time. Degrease, clean and inspect. Stiff links, tight spots, insecure joining links will get picked up – if it’s at the end of adjustment or can be pulled off the sprocket, it’ll get failed. Check sprockets are secure and not worn out with hooked or missing teeth. Drive belt? Inspect for damage or degrading rubber.
3 Got enough tread?
Failing an MOT for defective tyres is plain embarrassing. The legal minimum tyre tread depth is 1mm, though most tyres are past their best way before that anyway. Inspect the tyre for cuts, cracks or foreign objects puncturing it. Valves must be secure, in good condition and suitable for bikes – long rubber types are meant for cars and pose a danger if they make it on to your bike.
Follow our tips and your beloved will pass first time, every time


text:
Jawata Afnan (McGill University)
MEG estimation of resting state oscillations and functional connectivity: validation with an intracranial EEG atlas
Magnetoencephalography (MEG) is a widely used non-invasive tool to estimate brain activity with high temporal resolution. However, due to the ill-posed nature of the MEG source imaging (MSI) problem, the ability of MSI to identify accurately underlying brain sources along the cortical surface is uncertain and requires validation. We aimed to validate the ability of MSI to estimate the background resting state power spectra and connectivity profiles of 45 healthy participants by comparing MSI findings to in-situ measurements obtained from the intracranial EEG (iEEG) atlas (https://mni-open-ieegatlas.research.mcgill.ca/), at the population level.
We applied wavelet-based Maximum Entropy on the Mean (wMEM) as a MSI technique dedicated to localization oscillations. Next, we converted MEG source maps into intracranial space by applying a forward model to the MEG-reconstructed source maps, and estimated virtual iEEG (ViEEG) potentials on each iEEG channel location; we finally quantitatively compared ViEEG with actual iEEG signals from the same region in terms of spectral characteristics and connectivity profiles in the canonical frequency bands. For connectivity analysis, we calculated four widely used metrics- Amplitude Envelope Correlation (AEC), orthogonalized AEC (OAEC), Phase Locking Value (PLV) and corrected imaginary part of PLV (ciPLV) and compared the cross-modal spatial correlation between MEG and iEEG connectomes.
Spectral analysis: MEG spectra were more accurately estimated in the lateral regions compared to the deeper medial regions. Regions with higher amplitude in the ViEEG than in the iEEG were more accurately recovered. In the deep regions, MEG-estimated amplitudes were largely underestimated, and the spectra were poorly recovered. Moreover, MEG largely overestimated oscillatory peaks in the alpha band, especially in the anterior and deep regions. This is possibly due to higher phase synchronization of alpha oscillations over extended regions, exceeding the spatial sensitivity of iEEG but detected by MEG. Connectivity analysis: Preliminary results showed that the cross-modal correlation between MEG and iEEG connectomes was band-specific and the highest correlations were found for the beta band when connectivity measures considered zero-lag connectivity such as AEC and PLV. In contrast, the connectivity metrics that remove the zero-lag connectivity (such as OAEC and ciPLV) significantly decreased the cross-modal correlation. Compared to iEEG, MEG showed higher zero-lag connectivity, a well-known disadvantage of non-invasive source imaging resulting from source-leakage.
This study identifies brain regions, frequency bands, and connectivity metrics for which MEG source analysis is likely to be reliable, a promising step towards resolving the uncertainty in recovering intracerebral activity from non-invasive MEG studies.
Obai Bin Ka’B Ali (Concordia University)
Dialogue mechanisms between astrocytic and neuronal networks: a whole-brain biophysical modelling approach
Astrocytes, a major type of glia, possess assorted structural and functional properties making them inseparable from their neighbouring neurons. However, most published computational models of whole-brain activity, if not all, remain focused on neurons while ignoring astrocytes. We herewith introduce a biophysical model built upon neural network mass and compartmental modelling techniques, where large-scale astrocytic and neuronal networks couple their activity through glutamatergic and GABAergic transmission systems. We formulate a network scheme where neural dynamics are constrained by a two-layered structural network interconnecting either astrocytic or neuronal populations, and we ask how astrocytic networks contribute to whole-brain activity and emerging functional connectivity patterns. By developing a biologically plausible simulation approach based on bifurcation and multilayer network theories, we demonstrate that astrocytic and neuronal networks engage in a dialogue over fast and slow fluctuations or over phase-based and amplitude-based network connectivity. Our study is a step forward for more thoroughly investigating the role of glia alongside neurons in health or disease conditions.
Zhengchen Cai (McGill University)
Estimation of fMRI Responses Related to Epileptic Discharges Using Bayesian Hierarchical Modeling
Simultaneous electroencephalography–functional MRI (EEG-fMRI) is a unique and noninvasive method for epilepsy presurgical evaluation. When selecting voxels by null-hypothesis tests, the conventional analysis may overestimate fMRI response amplitudes related to interictal epileptic discharges (IEDs), especially when IEDs are rare.
Eighty-two epilepsy patients who underwent EEG-fMRI scans and surgeries at the MNI were included in this study. Surgical outcomes were classified with a follow-up of at least one year. IEDs were annotated by experienced neurophysiologists on processed EEGs in which scanner artifacts were removed. Anatomical and functional MRI preprocessing were performed using fMRIPrep. We proposed a hierarchical model involving local and global hemodynamic responses to IEDs using the Schaefer2018 atlas and Freesurfer subcortical parcellation as the prior. Hence, the fMRI response in each voxel was estimated not only by its own data, but also adjusted according to the local homogeneity of responses within each region of interest (ROI). ROI-level responses were further regularized to take into account the global homogeneity using the resting state networks to which they belong. The IED-related fMRI response was represented by the relative percentage change of the blood oxygen level dependent (BOLD) signal. A voxel-wise model was compared to ours from three perspectives: 1) the “type M(agnitude) error” of the estimated effect, as assessed by the ratio of BOLD percentage changes between two models; 2) the ability to differentiate BOLD percentage changes induced by brief (e.g., spike) and long-lasting (e.g., burst) IEDs; and 3) clinical utility in presurgical evaluation, as determined by the concordance between the cluster exhibiting the highest fMRI response and the surgical cavity. All parameters of the aforementioned models (e.g., effect, nuisance and autocorrelation) were solved simultaneously using a full Bayesian approach – Hamiltonian Monte Carlo in Stan platform.
The voxel-wise model overestimated fMRI responses compared to the hierarchical model, evidenced by a practically and statistically significant difference between the estimated BOLD percentage changes. Only the hierarchical model differentiated brief and long-lasting IEDs with significantly different BOLD percentage changes. Overall, the hierarchical model outperformed the voxel-wise model on presurgical evaluation, measured by higher prediction performance. When compared with a previous study, the hierarchical model showed higher performance metric values, but the same or lower sensitivity.
Our results demonstrated the capability of the hierarchical model of providing more physiologically reasonable and more accurate estimations of fMRI response amplitudes induced by IEDs. To enhance the sensitivity of EEG-fMRI for presurgical evaluation, it may be necessary to incorporate more appropriate spatial priors and bespoke decision strategies.
Dilanjan Diyabalanage (University of Western Ontario)
Physics-Informed Probabilistic Approach to Analyzing and Modeling Neuroimaging Data
In computational neuroscience, understanding the multifaceted dynamics within neural networks remains a pressing challenge, particularly in the context of the brain’s staggering complexity, comprising approximately 100 billion neurons. While traditional models have focused on local coupling and function, there is a growing consensus that a network-centric approach is indispensable for a comprehensive understanding of brain function. Against this backdrop, this study introduces a groundbreaking approach that leverages the mathematical principles of quantum mechanics to scrutinize neuroimaging data.
Our quantum-inspired model offers a novel framework for investigating network dynamics, complementing, and extending existing network science methodologies. It provides a nuanced perspective on neural information flow, enabling a deeper understanding of brain network topology. A significant feature of this model is its ability to integrate neuro-energetics, thereby enriching our understanding of metabolic processes within these intricate networks. Particularly salient is the model’s utility in examining the temporal dynamics of resting-state networks, which are key to understanding the brain’s baseline functional connectivity. Using predefined neural networks as a template, our model dynamically tracks network behavior, aligning with the focus on neural network inference from imaging data.
Significantly, this approach uses source-localized electroencephalography (EEG) data, allowing for a broader application in both clinical and research settings. A significant expansion of this research is the incorporation of Physics-Informed Neural Networks (PINNs) to extend the capabilities of the quantum-mechanical framework. PINNs serve as a computational bridge, facilitating the integration of physical laws into the modeling process, thus enhancing the model’s predictive accuracy and interpretability.
Adrien Dubois (Université de Montréal)
Normative modelling on large scale EEG
Neurodevelopmental disorders (NDDs) present a variety of symptoms and etiologies, which poses challenges for accurate diagnosis and personalized treatment. Although electrophysiology has demonstrated potential in revealing the neural basis of NDDs, inconsistent findings and methodological heterogeneity have impeded its practical applications. Furthermore, reproducibility and interpretability remain critical concerns in medical research. Our study aims to overcome these challenges by creating comprehensive models and integrating multiple databases into a single framework. We hypothesize that an enhanced approach to electrophysiology can identify reliable biomarkers of NDDs, enhance biological interpretability, and advance the development of actionable biomarkers and better understanding of biological mechanisms. To achieve this, we will establish standardized growth charts of electrophysiological measures using normative modeling on a large-scale dataset (N=5000) obtained from diverse cohorts. This approach will account for nonlinear age-related effects on EEG measures, gender and sex variations, and different cohorts, enabling rigorous statistical analyses of large-scale multi-site data. In addition to the psychiatric diagnosis, our databases include genetic conditions, which allows us to map the deviations and thus bridge the gap between genetic markers and neurophysiological outcomes. By leveraging advanced statistics techniques, including unsupervised and supervised learning, we intend to dissect the complex interplay between genotypic variability and phenotypic expression in NDDs. This multidimensional analysis aims to illuminate the underlying genetic contributions to observed electrophysiological patterns, paving the way for genotype-informed interventions and precision medicine in the realm of NDDs.
Maeva Gacoin (McGill University)
Effects of fluoxetine on macaque cortical functional connectivity following reward-based spatial learning
Despite the prevailing notion of stable synaptic connectivity in the adult brain, research indicates that residual plasticity can persist and be amplified through behavioral and pharmacological interventions. These interventions aim to heighten the brain’s responsiveness to environmental stimuli by manipulating the balance between excitation and inhibition, with glutamate as the excitatory agent and gamma-aminobutyric acid (GABA) serving as the inhibitory counterpart. Our study aimed to explore the network effects of re-establishing plasticity through intense reward-based spatial behavioral training, both with and without fluoxetine, a selective serotonin reuptake inhibitor known for reducing GABA levels. In a previous study (Gacoin and Ben Hamed 2022), we demonstrated that fluoxetine enhances reward selectivity when learning a spatial priority map. To investigate how serotonin availability impacts spatial priority maps and their interference with parieto-frontal and occipital function in visual decision-making, we conducted a longitudinal study with two conscious macaques. This study involved three distinct time points. First, a control baseline condition where we measured brain resting-state activity before any manipulations. Then, an assessment of resting-state brain activity after manipulating the spatial priority map through reward-based learning, effectively increasing the average reward in one visual hemifield compared to the other. Lastly, an evaluation of resting-state brain activity after reversing the reward-based spatial priority map manipulation while administering systemic fluoxetine injections, reversing the average rewards between hemifields.
We employed both ROI-to-ROI data-driven and ROI-to-whole brain hypothesis-driven functional connectivity analyses to understand the specific interactions between reward-based prioritization and fluoxetine on brain functional connectivity. Our findings show that the effects of reward-based learning on brain functional connectivity depend on whether fluoxetine is administered during the learning phase. In the hemisphere associated with the high-reward hemifield, fluoxetine enhanced functional connectivity between the dorsal lateral prefrontal cortex and striate and extra-striate cortex. In contrast, in the hemisphere associated with the low-reward hemifield, fluoxetine increased functional connectivity between the dorsal lateral prefrontal cortex and the parietal cortex. Our seed-to-whole brain analyses also revealed that reward-based learning induced selective changes in functional connectivity within both dorsal and ventral visual networks.
This global reweighing of functional brain connectivity during reward-based learning likely contributes to the behavioral effects observed with fluoxetine, as reported in our previous study. In summary, our observations enhance our understanding of how fluoxetine, in the context of learning-based plasticity, impacts the adult brain.
Laetitia Jeancolas (Concordia University)
Memory and Connectivity: Episodic and Semantic Memory and Their Interdependence in Normal Aging and Alzheimer’s Disease
The existence of a relationship between episodic and semantic memory has long been debated and is even less understood in the context of Alzheimer’s disease (AD). Here, we investigated the interaction between semantic knowledge and episodic memory processes associated with faces in normal elderly and mild-stage AD subjects, through the spectrum of electrophysiological and connectivity analyses.
A total of 19 subjects [mean age 69 ± 4 yrs] were included in this study (HM-TC project, Pitié-Salpêtrière, Paris), composed of nine patients with probable AD and ten age-matched healthy controls. The subjects underwent a T1-weighted scan and MEG acquisition during memory tasks, consisting in faces’ recognition. They were composed of blocks of semantic tasks, during which the participants had to discriminate famous from unknown faces, and blocks of episodic tasks, during which they had to indicate whether they saw the faces (which could be famous or unknown) in the previous semantic task. These tasks involved three types of memory: pure semantic retrieval, pure episodic retrieval, and a mixed operation of episodic retrieval of semantic information. Continuous MEG signals were segmented into epochs time-locked to stimulus onset.
We performed source reconstructions, using SPM12b. To compute the forward gain matrix, we employed the local spheres model and constructed a canonical mesh including the cortex and the hippocampus. To solve the inverse problem, we assumed IID and distributed sources, and conducted a group inversion.
The effective connectivity analyses were conducted using Dynamic Causal Modelling. We performed Bayesian Model Selection to compare the connectivity models (ROIs were selected using the source reconstruction and the connections were chosen based on a connectivity atlas). Then we performed ANOVAs on the connectivity modulations to assess the changes due to the type of memory and AD.
The source activations and connectivity in the mixed condition differed from pure episodic condition and showed some similarity with the semantic task, depicting the interaction between episodic and semantic memories. Moreover, AD group showed a decreased hippocampus activity and connectivity, but also an increase in occipito-parietal region during episodic memory.
Our study characterized the active brain sources and the connectivity patterns involved in semantic and episodic memories and in their interaction. We also showed how these memory neural correlates were affected in AD. Analyses on larger databases are necessary to confirm these promising findings, for a comprehensive understanding of the memory underlying mechanisms in normal aging and AD.
Ahmed Khan (McGill University)
Individualized modeling of neurotransmitter receptor influence on multi-modal measures of Alzheimer’s disease progression
Neurodegenerative disorders such as Alzheimer’s disease (AD) can be clinically heterogeneous and involve multiple interacting physiological systems, from metabolic, vascular and functional dysregulation to misfolded protein accumulation and atrophy. To resolve potential disease mechanisms and treatment targets, the molecular features underlying macroscopic physiological and symptomatic variability must be identified. As critical mediators of cellular signalling and pharmacological response, multiple neurotransmitter receptors have been associated with AD and targeted for symptomatic therapy, but we lack a comprehensive understanding of their role in disease progression and symptom severity. In this work, we combined multi-modal imaging data (tau, amyloid-β and glucose PET, and structural, functional and arterial spin labelling MRI) with the healthy spatial distributions of 15 neurotransmitter receptors from autoradiography in individualized computational brains, to characterize receptor mediation of multi-factorial brain alterations in the AD spectrum. We demonstrated that receptor architecture helps explain long-term brain re-organization in a heterogeneous aged population (including healthy controls, MCI subjects and AD patients). Furthermore, we identified 2 distinct yet overlapping axes linking receptor-mediated physiological interactions in AD with i) executive dysfunction and ii) memory, language and visuospatial impairment. This data-driven modeling approach can be used to infer latent molecular involvement and guide personalized treatment design.
Lu Wen Da (McGill University)
Tract-specific g-ratio using COMMIT: comparison with conventional g-ratio tractometry
Introduction: By combining diffusion-weighted imaging and magnetization transfer, the myelination of white matter tracts can be estimated using an analysis pipeline known as tractometry , where quantitative MRI maps are projected onto reconstructed white matter tracts to investigate its mirostructural properties. There are limitations associated with this technique; 60-90% of image voxels in the white matter contain multi-fiber configurations , leading to partial volume effects that bias the measurements of each fiber and conceal potential fiber differences. The COMMIT framework has been used to minimizing the bias stemming from crossing fibers [3-5]. We build on this work to calculate tract-specific g-ratio, a ratio between the inner and outer radius of the myelin sheath, and will compare it to conventional tractometry.
Methods: 10 healthy subjects (6 males, 29.2± 6.29 years old) were scanned and rescanned (< 3 weeks inter-scan interval) on a 3 Tesla scanner. The data was preprocessed using micapipe . Tract-specific g-ratio connectivity matrices were calculated using the axonal and myelin volumes obtained from a three-stage COMMIT filtering pipeline [3-5] using the Schaefer-200 parcellation . The conventional g-ratio tractometry was computed using the same streamlines and a voxel-wise g-ratio map .
Results and Discussion: Tract-specific data, with a wider dynamic range than tractometry, reflects the removal of partial volume effects causing smoothing in tractometry. The repeatability is high for medium to large tracts; and the smaller caliber tracts are excluded from subsequent analysis using an 80th percentile tract cutoff across all subjects. The largest 20% of tracts show good repeatability (correlation coefficient: 0.651). It is important to note that tractometry is more repeatable but sacrifices anatomical specificity.
The differences between tract-specific and tractometry g-ratios are most significant in temporal and frontal regions. We observe a relationship between tract-specific g-ratio and tract length and caliber: g-ratio is higher for longer tracts and lower for tracts with larger caliber. These results imply that the longer and smaller caliber tracts are associated with thinner myelin sheaths relative to axon caliber. This relationship is not seen in the case of tractometry where g-ratio does not change with respect to both tract length and caliber.
Conclusion: Our novel processing pipeline produced tract-specific g-ratio connectivity matrices with a wider g-ratio dynamic range compared to conventional g-ratio tractometry. By disentangling the g-ratio of tracts crossing throughout the brain, we were able to detect relationships between g-ratio and tract length and caliber that were previously concealed.
 S Bells et al., presented at the Proc. ISMRM, (2011). B Jeurissen et al., Hum Brain Mapp 34 (11), 2747 (2013). S Schiavi et al., Neuroimage 249, 118922 (2022). A Daducci et al., IEEE Trans Med Imaging 34 (1), 246 (2015). S Schiavi et al., Science advances 6 (31), eaba8245 (2020). RR Cruces et al., Neuroimage 263, 119612 (2022). A Schaefer et al., Cerebral cortex 28 (9), 3095 (2018). N Stikov et al., Neuroimage 118, 397 (2015).
Arsalan Rahimabadi (Concordia University)
Extended fractional-polynomial generalizations of diffusion and Fisher–KPP equations to model misfolded proteins propagation in the brain
Many practical applications require the investigation of diffusion or reaction-diffusion processes over complex structures, such as brain networks that can be modeled as weighted undirected or directed graphs. An archetypal example of such applications is the progression of neurodegenerative diseases such as Alzheimer’s disease (AD) in the brain connectome. AD and more than 25 other identified tauopathies, including Pick disease (PiD), progressive supranuclear palsy (PSP), argyrophilic grain disease (AGD), corticobasal degeneration (CBD), and frontotemporal dementia with parkinsonism-17 (FTDP-17), are characterized by the aggregation of specific microtubule-associated proteins (MAPs) called tau proteins which have been extensively studied for their function in the assembly and stabilization of microtubules providing a structural backbone for axons and dendrites of neurons. Although this protein is natively unfolded and its propensity for aggregation is negligible, post-translational modifications, such as phosphorylation and truncation, can promote the aggregation of monomeric tau. Notwithstanding the fact that it has been confirmed that tau pathology alone is sufficient to induce neurodegeneration by the identification of tau mutants in patients with FTDP-17, extensive research is still underway to determine the pathways and mechanisms underlying tau aggregation in tauopathies and their effects on the spatiotemporal pattern of tau pathology progression in the brain. The celebrated Fisher-Kolmogorov-Petrovsky-Piskunov (Fisher-KPP) reaction-diffusion equation are becoming increasingly popular for use in graph frameworks by substituting the standard graph Laplacian operator for the continuous one to study the progression of tauopathy in AD. However, due to the porous structure of neuronal fibers, the spreading of toxic species can be governed by a nonlinear diffusion process, and if this is the case, the standard graph Laplacian cannot adequately describe the dynamics of the spreading process. To capture such more complicated dynamics, we have recently proposed a diffusion equation with a nonlinear Laplacian operator and a generalization of the Fisher-KPP reaction-diffusion equation on undirected and directed networks using extensions of fractional polynomial (FP) functions. A complete analysis has been also provided for the extended FP diffusion equations, including existence, uniqueness, and convergence of solutions, as well as stability of equilibria. Moreover, for the extended FP Fisher-KPP reaction-diffusion equations, we have derived a family of positively invariant sets allowing us to establish existence, uniqueness, and boundedness of solutions. To illustrate the potential applications of the proposed extended FP equations, we have examined nonlinear diffusion on a directed one-dimensional lattice and tauopathy progression in the mouse brain.

domain: literature


All Rights Reserved. by OR Department of Fish & Wildlife Staff of the Alsea River. The closure will be for new construction and maintenance at the boat ramp and adjacent facilities. 2016 Alsea River Fishing Report. Low and clear conditions combined with sunny blue skies have created tough conditions. The earlier returning left maxillary clipped fish are past peak and numbers will continue to decrease for the rest of the season. Fall Chinook fishing on the Nestucca has been fair to good this season. Siletz River Fish Report Lincoln City Or. This is still a great time of year to catch some cutthroat trout before it closes for the winter. AZGFD; Reports ... Arizona Fish Report Alsea River Fish Report for 3-13-2019. I was wondering with the rains last week how distributed they would be in the system by now. The first few weeks in September is typically when the fishing improves and it will continue to get better as the season progresses. All Rights Reserved. Applegate River is Open for Trout Fishing, Middle Fork WIllamette River Fishing Report, Smith Reservoir Under Construction Until 2021. Alsea River Fishing Access Reports. A beautiful morning on Mile 202. Online pricing may vary from in-store pricing. Trout fishing in streams is open until Oct. 31. Expect more fish to show up with each rise in the river level from now through April. No wildlife of note, just a few crows, a dozen or so gulls sitting on the bank near the people fishing, and one concentrated group of a few dozen crab molts. The bag limit for the Alsea River is 1 wild Chinook per day and 5 per year for the 2020 season. Excellent Destination For Kids Out on Spring Break, Winter Steelhead in The Applegate Run Later Than Most Streams, First Stocking to Receive 20,000 Legal Rainbows This Week, Winter Steelhead Fishing Conditions Continued to Improve. Although the numbers of fish entering the Alsea hatchery trap remain low anglers are still catching fish throughout the system, primarily on the North Fork around the hatchery. The Alsea still gets a good amount of the early returning stock that peaks in December and January, as well as a later stock that peaks in February and March. That’s better than several nationally-known rivers did that year, although the Alsea’s typical catches in a decent season are a still very good 2,000 or more hatchery-marked steelhead. Get Special Offers Delivered Right to Your Inbox. by OR Department of Fish & Wildlife Staff 10-2-2019 Website. Learn More, 11/01/2020 All Metro Parks and boat ramps are now open, but may have modified operations. Nehalem River Fish Report Nehalm Or. The warmer weather is warming up the water temperatures and making the fish more active and they are starting to move around in the basin. ... Summer steelhead fishing is still slow but conditions are good right now to catch a late summer steelhead. Was last stocked the week of Aug. 17 with 3,000 rainbow trout. Rain is in the forecast for later in the week and this should improve the fishing. Alsea River Fishing Report Alsea River - Alsea, OR. River Fish Reports. All Rights Reserved. The popular NF Alsea fishery is very low and clear and has been slow. Website. by OR Department of Fish & Wildlife Staff 3-13-2019 Website. Website. On this visit, I noted evidence of sand dumping from the bluff onto the beach, which I had seen on my initial exploratory visit on 12/23/2019, when I observed a front end loader dumping sand over the edge of a steep sand bluff. Fall Chinook fishing on the Alsea River continues to be fair to good. Expect more fish to show up with each rise in the river level from now through April. Cutthroat trout fishing is open on the Alsea River until Oct. 31. ***Reminder*** The deadline for salmon fishing on the Alsea River is River Edge boat ramp located at river mile 28. The lower river has been in good shape and the drift boaters have been catching a few fish every day. Website. After finishing my walk on 12/23/2019, I later drove down Oceania Drive, which parallels the beach, and saw the origin of this sand, a front end loader clearing sand from the driveway of a house on Oceania. The river shot up on Sunday and is now dropping into shape and should fish well for the rest of the week and into the weekend. Bobber fishing with jigs/bait, drift fishing, and casting lures are all effective ways to catch these hard fighting fish. by OR Department of Fish & Wildlife Staff Winter steelhead fishing has been slow on the Alsea River. Warmer weather and some rain will warm up the water temperatures, which should get fish moving and increase their activity. of the Alsea River. The bag limit for the Alsea River is 1 wild Chinook per day and 5 per year for the 2020 season.Cutthroat trout fishing closes this Saturday, Oct. 31, on the Alsea River as well as all of the other mid-coast streams. Arizona.FishReports.com © 2020. Although the numbers of fish entering the Alsea hatchery trap remain low anglers are still catching fish throughout the system, primarily on the North Fork around the hatchery. The Alsea still gets a good number of the early returning fish that peaks in December and January, as well as a later stock that peaks in February and March. Nothing of note, just a few crows, a dozen or so gulls sitting near the people fishing, and one concentrated area of approximately three dozen crab molts (see photo), Sand dumping on on steep sand bluff -- see below. Any reports on the Alsea river? The only evidence of unusual human activity I saw were two areas of sand dumping over the edge of the steep sand bluffs towards the southern edge of the spit, which I had seen occuring on my previous visit on 12/23/2019, when I photographed a front end loader dumping sand over the edge of the bluff onto the beach. The earlier returning left maxillary clipped fish are past peak and will continue to decrease for the rest of the season. Due to low forecasted fall Chinook returns, this year’s daily bag limit has been reduced to 1 wild Chinook per day and 5 per year for the mid-coast aggregate (Siletz River to Siuslaw River).
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30 Minutes with Aurora Cannabis (TSE:ACB) (NYSE:ACB) CCO Cam Battley
Aurora Cannabis Inc (TSE:ACB) (OTCMKTS:ACBFF) (FRA:21P) CCO Cam Battley joins Midas Letter for a long-form interview diving into the latest developments inside one of the world’s largest and leading cannabis companies. The CCO states Aurora has “achieved a level of scale and discipline that sets us apart” [from the competition] which should see the company separate from the concerns in the cannabis market as a whole. Based on Aurora’s guidance, the company is anticipating between 90 and 95 million in cannabis revenues, which would put Aurora at the top of the cannabis pile in respect to revenue. James quizzes Mr. Battley with some ‘tough question’ such as when the company will be profitable, competing with low-cost, outdoor cannabis and extracts on the global stage and when Aurora’s relationship with Nelson Pelz is going to result in value for shareholders. Recent press releases are also discussed such as Aurora’s credit facility upsizing to USD$280 Million and their partnership with UFC® for clinical research of hemp-derived CBD products for MMA athletes.
James West: Hey, I’m joined by Cam Battley, now. He’s the Chief Corporate Officer of Aurora Cannabis – you all know where that trades. Cam, welcome back.
Cam Battley: Nice to see you again.
James West: Cam, it’s good to have you back. How’s your summer going?
Cam Battley: Very good, other than the obvious, with respect to the markets being red in the sector.
James West: You know, to me it strikes me as a healthy evolution of the market that it goes down as well as going up.
Cam Battley: I’m glad you think it’s healthy, because our shareholders are not using that particular word.
James West: Hmm. I can just imagine. Frustrating as it may be for markets to aspirate, but being a living organism, as most markets are, they do have to breathe out as well as in.
Cam Battley: Look, you’re absolutely right. And I would say, first of all, a couple of things. One, Aurora has been distant from the drama and the convulsions and the difficulties that we have seen in this sector, and I find that sometimes a little frustrating that we keep quietly keeping our nose to the grindstone and executing consistently, continued growth across all of our distribution channels, and we’re doing what we promised to do, not just this year, but over several years. And I would honestly like to see, over time, something that I’d like to achieve, is a bit of a decoupling of Aurora from the sector.
Bundling us in with every other company in the sector, I don’t think, is appropriate anymore. I think we’ve achieved a level of scale and discipline that sets us apart. But, let me add this: I know that there’s a lot of concern about the cannabis sector as a whole, and I think that there’s perhaps more concern than warranted. This sector is going to be okay, and sometimes, you know, in a market that is so heavily retail, as cannabis is right now, overwhelmingly so; we know that retail markets tend to trade on emotion and on news, and that’s why you see a lot of the, you know, the volatility that you don’t see in mature industries.
I think it’s probably worthwhile for investors in the sector to take a deep breath, take a look at what they liked about those companies in the first place, take a look at what they like about the opportunity of being early movers in a brand-new global industry, and reassess whether things are really so bad. I don’t think they are. I think the sector is going to be all right.
James West: Sure. Well, it should be easy enough to differentiate yourself with the rest of the industry, would be, just turning a profit.
Cam Battley: Yes.
James West: And your recent projections suggest that, the guidance suggests that, you are getting very close to that and some serious revenue.
Cam Battley: Well, so, yeah. We put out guidance, you know, a little over a week ago, and I think it was pretty important. We’ve seen some kind of weak earnings reports from some companies; we wanted it to be clear that we’re not experiencing some of the challenges that some of the others are, temporary or otherwise. And so based on our guidance, we’re anticipating in excess of 100 million in net revenues – over 90 million, between 90 and 95 million, in cannabis revenues, and that makes Aurora the global revenue leader in the cannabis sector, which is gratifying, because it’s something that we anticipated quite some time ago, and I think a lot of people found – I think they had a hard time believing that we’d be able to achieve it.
But we have, and you know, if you just take a look at the last 18 months, Aurora’s production has gone from about 5,000 kilograms per year to over 150,000 kilograms per year. So it’s a, you know, 30 times increase in a very short period of time. And beyond that, we’ve established what we believe is the global benchmark for cannabis production: no lost crops, very high quality, yields that I don’t think anybody’s ever seen at scale before. And we’ve found the markets, globally, to be able to distribute that. So we’re the leaders in medical cannabis in Canada. We’re the leaders in medical cannabis internationally. And we’re the leaders now, apparently, according to third party reports, in the Canadian adult consumer market, as well.
So it’s continued growth. It’s a lack of drama, a lack of crisis, and that’s based on solid production techniques. It’s based on a very strong management team with a few people that I do want to make shout-outs to. And also, I think it’s a validation of our overall business model, and that’s a testament to Terry Booth, our CEO and co-founder.
James West: Okay. So you’re reporting your Q4 and year-end for fiscal 2018, correct? Now, how is your net number going to look relative to analysts’ consensus?
Cam Battley: We’re going to be pretty darn close. We, you know, obviously maintain close relationships with the analysts; we give them access to all the information that they need. So we’re going to be pretty close to where analysts have anticipated that we would be. It’s one of the reasons that we put out this guidance; we want there to be no surprises. We want to lead this sector in transparency as well as in other things, and we want to have clarity, and we want to let people know what to expect.
So that’s why we put out the guidance. We are continuing to track towards positive EBITDA, as indicated earlier in the year, and I’m very, very pleased with that. And I’ll tell you why: we, by putting a stake in the ground that we were taking profitability and that that path to profitability, seriously, it applied a whole new level of discipline to our operations. We’re not pushing out the promise of profitability, you know, year after year after year. And while we do believe that it’s critical to establish infrastructure globally while this window of opportunity exists, we don’t think that that conflicts with the opportunity to achieve profitability.
So, I’m very, very pleased with the way we’re doing. I’m very pleased with the way we’ve disciplined our operations, and managed our resources. But once again, you know, you’ve heard me say before, and I think I mentioned it on our last earnings call, that in my view, over the next couple of years, the critical success factor in this sector will be producing and selling via multiple distribution channels, a hell of a lot of cannabis. And we’re doing that like nobody else right now. So I wouldn’t want to be any other cannabis company other than Aurora today.
James West: Sure, of course. All right, let’s talk a bit about your upsizing of your traditional banking facility from 200 million to 360 million. Obviously, lots more firepower in the bank account to do the things that you guys are doing; what is the implications of that come August 2021? Under what circumstances would you not be in a position to pay that back according to the schedule required?
Cam Battley: Look, according to our projections, we’re not going to have any difficulty paying back debt. The most important things to take away from the upsizing of the credit facility is, I think, it’s about confidence. It’s about the consistency of our operations and our execution, and it’s about the credibility of the company. Our assets are valuable, and we validated those assets, such as our Aurora Sky facility at Edmonton International Airport – and by the way, we have additional Sky-class facilities under construction in Medicine Hat and, you know, Denmark – but it speaks to the credibility of the company.
This is the largest amount of traditional debt that any cannabis company has been able to access thus far, and you know, I’ve said this before: I think that this is, you know, very important for Aurora in that it puts us apart from the rest, but, Aurora is at the leading edge of this industry. And so I think a broader takeaway would be that this is good for the industry at large. That Schedule One banks, and we’ve actually added additional Schedule One banks to the syndicate that is providing this credit facility – Schedule One banks are now leading in. They’re getting involved. They’re accepting and believing and banking on the fact that this is going to be a successful long-term industry, and it’s a good risk.
James West: So for shareholders, you’ve slowed down on the acquisition trail which –
Cam Battley: You noticed.
James West: Well, as a shareholder, who wouldn’t notice that? And that is comforting to shareholders, because every acquisition, while it does build the footprint of the company on the global stage, it makes one a little bit uncomfortable with the idea of earnings per share in the future. So –
Cam Battley: Well, this goes back to what I said about the guidance that we put out in January of this year. We signaled a shift in our strategy – an evolution, I guess, in our strategy. And what we said at the time is that we believe that we had substantially assembled the assets and capabilities in Canada that we needed to be a, or the, leader going forward, and that our future focus for M&A would be a on global scale, opening up new markets. And we’ve done that successfully, too; now, we’re operating in 25 global markets, 25 countries, and that’s by far the biggest global footprint in the industry.
But along with that, and along with the new discipline and that focus on that pathway to profitability, we also indicated we would be slowing down some of the M&A. It’s not that we regret anything we’ve done in the past, it’s just we felt we had reached a point where we had those assets and capabilities, and now we were able to shift gears. And it happened at a very good time, because what I’ve been hearing and what we’ve been hearing from the institutions is that they’re looking for a greater focus on that pathway to profitability, that we can’t keep operating, keep raising money, keep expanding, without caring about and putting a schedule on when we’re going to get to profitability.
So I’m pleased that I think we got the timing right with the major institutions, and I think that that will pay off for Aurora very well, because I think probably relative to most of our peers, we’re going to be ahead of them in terms of the timeline to profitability.
James West: That’s super intriguing. Now, the whole industry is suffering from a discounting process over the course of the summer, largely because investors sell in May and go away when they’ve made a lot of good money. But also, the earnings have been disappointing from the industry at large, primarily at the point of sale. And what is clearly emerging is that the influence of the black market on the ability of companies to generate significant revenue is not just present, but expanding, as evidenced by Colorado’s release recently of a chart showing that each year they seize more plants from illegal operations because these non-licensed entities are able to hide behind the licensed industry and do a better business.
To what extent is that going to impact Aurora’s ability to generate profit from significant sales in jurisdictions where a black market is still persistent?
Cam Battley: You know, there was something really interesting in the most recent StatsCanada report that showed that the attitudes of purchasers of cannabis, both legal and black market, the number one driver was safety and quality. 75 percent of people put that as the number one consideration.
This is where Aurora kills it, obviously. We don’t use pesticides at our Aurora facilities; we produce exceedingly high-quality cannabis that is done very, very well. We’ve got the leading brands in the industry, and I think, you know, as I say, third party reports are indicating that we’ve taken over the lead now in the Canadian adult consumer market.
So if you’ve got that on your side, and you also have the ability to, you know, to supply multiple jurisdictions across the country – and we’re in every jurisdiction across the country – and you have the ability to expand into markets that other companies simply don’t have the scale or the production to enter, it puts us in a very favourable position.
So, you know, where is the black market? You know, the indications that we’ve seen from what data exists – and let’s admit that it’s imperfect – is that the legal market is gradually but steadily replacing the illegal market. There will always be some people who will look for the lowest price; fair enough. But where we’re going is to a normalized market. You know, I often say, when was the last time you bought bathtub gin?
James West: [laughter] Bathtub gin? That’s a good one!
Cam Battley: Right? Well, so this was what was big during Prohibition – people literally making liquor in their bathtubs. And that doesn’t exist anymore.
What we’re also seeing is a lot of talent who previously have come from the gray and black markets, moving into the legal and regulated market. That’s a normal course of affairs. And so, over the course of the next few years, I would anticipate in Canada, in the US consumer legal states, and in other future jurisdictions that do legalize cannabis for consumer use, you’ll see normalized markets develop, and the black market will get smaller and smaller and smaller. And we’re already seeing that phenomenon in the consumer legal states in the US, where the overwhelming majority of cannabis sold is via the legal market. So, we’ll get there.
James West: Fantastic. Okay, tough question number one: when is Aurora going to be profitable?
Cam Battley: What we said in our most recent guidance is that we remain on-track towards EBITDA positive, and particularly EBITDA positive on cannabis operations. So I don’t want to be incarcerating for violating securities regulations, and I’ll wait until we report before September 15th, with our year-end. But if you’re asking me if I’m confident that we are on track, we’re still on track towards EBITDA positive and on that pathway to profitability, yes. And I think we are ahead of most of our peers, as well.
James West: Okay. Tough question number two: how is Aurora going to compete with low-cost, equatorial-grown, outdoor cannabis and their extracts, on the global stage, competing from a place where the cost of sales must be higher given the fact that these are ultra-high-tech, purpose built facilities of significant scale and with huge CapEx?
Cam Battley: This is one of your patented, really interesting, long, multi-level questions. [laughter]
James West: I should patent those, shouldn’t I?
Cam Battley: You really should. So, let’s break it down: first of all, we’re involved in outdoor grow, as well, in Latin America.
James West: The largest one in Canada, I understand.
Cam Battley: The largest one in Canada, in British Columbia, in Westwold in British Columbia, as well as another –
James West: Did you say Westwold?
Cam Battley: Yes.
James West: Is that my wold?
Cam Battley: Not Westworld, Westwold.
James West: Damn.
Cam Battley: And also, in Quebec. And what we’re doing right now, we’re essentially in the research phase with our outdoor grow. But you’ve heard me say before that we’ve got a lot of science talent in our company, including one of the cofounders of Anandia Labs, who is now our Chief Science Officer, and that’s Dr. Jonathan Page, who led the team that first sequenced the cannabis genome.
And through our plant science, separate from our human science, which is the clinical trials – through our plant science, and through a new breeding facility that we’re building in British Columbia, in Comox – we’re identifying strains that can be optimized for growth in any condition. Indoor, outdoor, greenhouse, northern latitudes, equatorial, and so on.
We do anticipate that outdoor grow will be a piece of the puzzle, and that’s why we’re investing in it. At the same time, we are thinking globally. We’re thinking like a global enterprise. And the challenge with outdoor grow is that there’s too much risk associated with it in order to build a global enterprise solely on that basis, because if you think about it, outdoor plants are, they’re vulnerable. This is why we started to, you know, use greenhouses and other facilities for, you know, growing plants of all kinds.
If there’s a big wind, you can lose a crop. If there’s a major rainstorm or hailstorm, it can wash the trichomes – the crystals of cannabinoids – right off the outside of the flower, because it wears its medicine on the outside, right? You have the risk of disease, you have the risk of pests, you have risk from pesticides from nearby agricultural facilities, because it’s all in the wind.
So, we believe in outdoor growing; we think it’s part of the puzzle. We are going to be engaging in it, and we think we’re going to do it better than others because we’re going to have the science backing the strains that are the hardiest, that are the most disease-resistant. We’re going to be selectively breeding for those characteristics. So, there’s that.
Now, the other thing to bear in mind is, think about any other industry. You will see in manufacturing, for example, that it’s coming to make a choice between producing in a developing country, for example, that has low labour costs, or producing in a developed country and using high technology. Does that sound familiar?
James West: Mm-hmm.
Cam Battley: So this is why we are hedging our bets. We are going to be producing low-cost cannabis, mostly for extraction, on an outdoor basis. But we’ve also, we have completely validated this concept of our Sky-class facilities, these mass-scale indoor facilities with a glass roof, with 100 percent control over the critical environmental variables. And I think we’ve seen by, you know, some of the performance of some of our peers that being able to produce without crop loss, being able to produce that really high quality product in a controlled indoor environment, being able to deliver extremely high yields and improving yields, and those high levels of cannabinoids or active pharmaceutical ingredients, that’s something that completely differentiates us from everybody else. There’s nobody in the industry who’s developed this kind of technology.
And one of the other characteristics of these high-tech, highly automated indoor grows using robotics is, it’s low-cost. And this is where we get our high gross margins. So we’re setting the pace for the entire industry in terms of margins, and that’s gratifying, but it’s based on a couple things. First of all, we think we will be able to command a very good price for our products, whether it be dried cannabis or derivatives. And we also know that we’re going to be able to produce for a lower cost than virtually anybody.
And I think ultimately you’re going to see the cost of our highly automated facilities’ production and the cost of outdoor grow – the real cost, including QA costs and including, you know, being able to access markets – I think you’re going to find those costs converging.
James West: Okay. Let’s take some of the questions that our audience has so thoughtfully come up with. Simon Cherette (phon) says, please ask Cam about possible new markets in Thailand, Mexico, and how much market share Aurora has taken from Canopy/competitors over the last quarter.
Cam Battley: So, let’s start with the last first: I’m not really 100 percent confident in the sketchy data that we’re able to get thus far in terms of the consumer market, but there are third party reports that indicate that Aurora has moved into first place in the Canadian adult consumer market, which is gratifying. We know that we’re putting out great products; we know that our brands are in demand, and we know that we’ve got the production to meet the demand and, you know, recently, we’ve seen, you know, one of the companies in this space get hit by Health Canada.
James West: Oh, right, okay.
Cam Battley: And what that means is, there’s a very large amount of product that won’t be there. So, you know, we’ve heard predictions as to when there’s going to be oversupply in the Canadian market and it keeps getting pushed back, and this has just simply done that again.
So we’re, you know, we’re more than prepared with the production, I think more production than anybody else, to fill that gap, as well as on the medical side. So that’s the first part.
The other part is with respect to new markets, and we’re seeing enormous interest. I actually just had a delegation from Thailand into Aurora Sky in Edmonton this week, led by the Thai ambassador to Canada and involving a number of Thai government officials and researchers from different universities. There is enormous interest, and I love this – there’s enormous interest in learning from Canada’s experience.
The same goes for a number of countries on different continents around the world, that they want to learn from what Canada has done with respect to establishing our medical cannabis system, and replicate those successes.
I would gently suggest that there are some things that Canada could have done better, and perhaps I’m a broken record, but it won’t surprise you to say that I don’t think that it’s right to tax medical cannabis. In Canada, that’s the only prescription product for which any tax applies, and we have both excise tax and GST/HST on medical cannabis in Canada, and if you think this is a preview of something that I’d like to talk about ahead of the Federal election, you would be right.
James West: [laughter] Okay.
Cam Battley: But, you know, let’s give Canada a lot of credit, and particularly the public servants at Health Canada. They put together a medical cannabis system in a hurry, under orders by the Supreme Court of Canada, and they did it exceedingly well, and they did it to the point where other countries are coming to visit us to learn how it’s done. We’re the leaders. That pleases me. Makes me patriotically proud.
James West: Sure. I’m with you, there. Okay, John Doe says, what is your plan –
Cam Battley: John Doe?
James West: John Doe.
Cam Battley: I don’t think that’s a real person.
James West: Oh, it could be John Doo. Well, that’s just their screen name. But his question is, What is your plan for the US hemp market.
Cam Battley: To enter it.
James West: [laughter] I like that. Short, and to the point. Matt Barone (phon) says, James, please ask Cam some tough questions: whether or not they will be EBITDA positive – we just covered that. Latin America and their plan to enter the US market – we kind of just covered that.
Cam Battley: I’ll go into a bit more detail about that. So Latin America, you know, we’ve established very strong infrastructure there. It is performing well. It’s taking a long. We do have to wait for the markets to actually launch in some countries. Brazil is a good example. You know, there’s limited opportunities right now, but there are going to be very major opportunities, and that’s a very large population. In fact, the key reason for our investments in ICC Labs and elsewhere in Latin America is because we know there’s going to be a strong market there, and we want to get in first. We want to get in early, establish the relationships, build that infrastructure, so that we’re ready as the markets switch on. Initially medical, and we anticipate in certain countries, ultimately consumer. There have been some noises about consumer legalization in a number of countries in Latin America.
So that’s a population of 600 million people, and you want to be early. You want to have those relationships; you want to have the infrastructure prepared, and you want to be able to take advantage as those markets start to grow. So we’re very, very pleased with that. What was the other part of the question? Oh, entering the US.
So as I’ve said before, our US strategy is multiple points of entry, and we’ve been in the US now for some time, since, oh, I guess about a year ago, with Australis Capital, which is assembling this lovely suite of assets and capabilities in the US, and for which we have a back-in right, and that was our first step into the US market.
We’ve also entered the US market through our partnership with UFC. Are you a fan of mixed martial arts?
James West: I am a mixed martial arts fighter.
Cam Battley: Holy cow. We’re going to have to get a beer.
James West: [laughter] I’m just kidding. I am not a mixed martial arts fighter in the UFC sense, but I have fought with every aspect of my body over time in various situations, so…
Cam Battley: You must need some CBD.
James West: I definitely need to be a CBD consumer.
Cam Battley: Because so do the fighters. And so we have a research partnership with the UFC, a multi-year partnership.
James West: We had a UFC fighter on as a guest recently.
Cam Battley: Really?
James West: I can’t remember his name; he’s a Canadian contender, I’m going to say championship, but we’ll – I’ll show you that segment in an email, but –
Cam Battley: Lovely.
James West: Now that I know that Aurora is actually UFC connected, I’m going to reach out to more of those guys.
Cam Battley: So, we are, and in fact, a couple months ago, I was with our team, our extended team, in Las Vegas and I got to see my first live UFC fight, which was astonishing. It’s really intense, and these athletes, they really are incredible, because they train year-round, right? So they don’t have an off-season. They train and fight year-round, and the performance institute established by the UFC to help these athletes be in absolutely optimal shape, is incredibly impressive. In fact, the entire UFC operation is massively impressive, and we’re delighted to be partners with them.
But what we’re going to be doing is researching together the therapeutic utility of CBD for things such as injury recovery, exercise recovery, and even injury prevention. This is a very significant entry and a long term partnership, so a very significant entry into the US market.
And then of course, you know, people are wondering when are we going to make a move with respect to hemp-derived CBD. When are we going to make additional moves into the US? And obviously, I can’t reveal that right now; once again, we have to be worried about selective disclosure every time we talk about it. But we do anticipate moving into the US via different points of entry, and I’ve said it before, and I’ll say it again: if you want to be a global leader, you have to be a leader in the United States, and we will be.
James West: Okay. Everybody – there’s actually several instances of people wanting to know, and I’m just going to qualify their questions into a more linear sort of topic: When is the relationship with Nelson Pelz going to result in some value for shareholders of Aurora?
Cam Battley: You know what? I would actually say that the relationship with Nelson Pelz is already paying off. You haven’t seen us announce yet partnerships with companies in mature industries, but you’ve heard what our strategy is, and that is to optimally enter multiple verticals. And also, not give away control.
So we’ve seen the experience of a couple of companies in our sector who’ve given up control. They’ve given up control of their Boards and significant equity to a single company in a single vertical, and that’s not the way we want to go. We think that we know best how to open up cannabis markets, both medical and consumer, on a global basis, and it’s not being arrogant. It’s simply that in a sector that is brand-new, for which there’s no blueprint, and there’s no map forward, we think that we’ve made more right moves than anybody else, and we don’t think that another company in some other mature industry can easily come in and tell us how to grow the global cannabis business better than we can.
So, maintaining our independence is key. Partnering with multiple companies in different verticals is our objective. Nelson is the most, not just connected, but wise advisor we could possibly have. And so that is moving forward. I know that people would like us to have announced, you know, some partnerships by yesterday, but the reality is, it takes time. The negotiation happens on both sides, and we want to get it right. You know, you’ve heard me say, let’s measure twice and cut once. Because once you establish these long-term, significant, multi-year partnerships, it’s very hard to modify them. So you really want to get it right the first time.
James West: You bet. Okay, Lost in Boston wants to know: I wish I could get some Aurora swag to wear in spirit of the call. Can we order –
Cam Battley: Is that lost in Boston, or lost in Bolton?
James West: Bolton! Sorry, Lost in Bolton.
Cam Battley: Who’s a Twitter follower.
James West: Right!
Cam Battley: Shout out to Lost in Bolton.
James West: Okay, so says, I wish I could get some Aurora swag to wear in spirit of the call. Can we order swag in the US yet?
Cam Battley: You know what? I actually checked up on that when I saw that Tweet, I think it was in an airport, and according to our current regulatory guidelines, we are not able to sell in the US. But, it’s under review, and I do hope that through our Aurora gift shop, we will be able to sell, obviously non-product swag.
James West: Right.
Cam Battley: And we’ve got enormous demand for it. People love the T-shirts and the hats and the hoodies and all the other swag that we’ve got.
James West: Okay, and that leads me to Tough Question Number Four, we’ll call it. To what extent does the Canadian rules governing the advertising and promotion of cannabis products handcuff companies like Aurora from generating a robust profit?
Cam Battley: Okay. There’s two questions there: Does it constrain us from generating a robust profit? No. No. And the evidence of that is our leadership in, you know, all of the different segments: Canadian medical, global medical, and Canadian consumer, and the attractiveness of our brands. Even in a marketing-constrained situation, our marketing department has done a very, very good job, and we are differentiated.
And a big part of that, I’ll add, is based on quality. Quality is king, you know? And if you don’t produce quality products that people actually want to consume, you’re not going to be there.
So, does it constrain us from generating profit? No. Does it constrain us in another way? Yes. And this is a conversation that I do want to have with the Federal parties. They need to understand that the current regulations that govern packaging, branding and marketing on cannabis are both scientifically not valid in that there’s ample evidence to show that cannabis is a more benign substance than alcohol on both an individual health impact basis and on a societal impact basis. I feel very strongly about this. And you know, we’ve constrained the packaging, branding and marketing of cannabis, I would say, excessively.
And it should be, and I’ve said this before the law was even passed: it should be harmonized with beer, wine and liquor. If you can advertise in appropriate ways to appropriate audiences on an age-gated basis, beer, wine, and liquor, well, by God, you should be able to do the same thing with cannabis products, which scientifically are more benign.
Now, why does this matter? Because on a longer term basis, we have got to let these leading Canadian companies establish brand equity. We’ve got to be able to build brands. Right now, you know, I’ve been very clear: I think that the number one critical success factor in this sector globally over the next couple of years is being able to produce and sell a lot of cannabis, and being able to open up new markets and do that as much on a global basis as you possibly can. And we’re killing it that way.
But I want the opportunity for Aurora and other leading Canadian companies to be able to establish long-term global leadership by letting us build brands. Every company, in every industry, needs to be able to build brands to differentiate from everybody else and to compete with global companies, right? And so this is something that needs to be revisited. It’s understandable that we had to start with tight regulation with the advent of this market, but now, let’s have that conversation again. Let’s focus on a shared objective, which is continued Canadian leadership in this new global industry.
Wouldn’t it be a damn shame if Canada was the leader in establishing a national medical cannabis system, in establishing consumer legalization and a properly regulated system at that, that’s going to work very well – wouldn’t it be a shame if we set that leadership up, and then let it drift away because we wouldn’t let these companies be grown-up companies?
So I think it’s a great question from your listener, and it’s something I’m going to be talking about, and I think the industry is going to be talking about, a lot more in the lead-up to the election and for some time after that. We’ve got to be real. We’ve got to understand that establishing global leadership means a certain amount of give and take with government.
James West: You bet. Cam, that is a plethora of input, and thank you very much. As usual, you have been an educational source for so long; thanks for joining me again today.
Cam Battley: Always nice to see you.


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Figurine Introduction: Comic Ansurium 014 Cover Illustration “Koinobori”
We had the chance to be the first ones to see the new Koinobori figure by Daikikougyou!
Koinobori by Daikikougyou is based on a popular illustration from Pixiv, which was featured on the cover of Comic Ansurium 014.
Feast your eyes on these sensational promotional pictures!
Find the figure on amiami
Check out Daikikougyou’s social media channels:
Twitter (JP): https://twitter.com/DAIKIkougyou

domain: hobby


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Here is a Free Retina Icon Set, which will help each iPhone or iPad application developer make high resolution GUI for Retina displays. The icons from this set can be used in navigation, tab bars and toolbars, as they specifically meet the icon guidelines for iOS application design.
A wide range of image sizes is included into this collection. It allows to use them with iPhone 4 and iPhone 5 retina displays. All the images have a transparent background and are available in two colors: black and white.
Technically, there are unique app icons created in matching style in a PNG format. The sizes for navigation bars of the following devices are available: 20x20 and 40x40 pixels (high resolution) for iPhone and iPod touch, 20x20 pixels for iPad. The tab bar sizes include a 30x30 pixels icons for iPad and 30x30 and 60x60 pixels icons for iPhone and iPod touch.
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Other Windows Software of Developer «Aha-soft»:
Delicious Love Icons Speed up development of dating products and enhance online dating Web sites and software with ready-made Delicious Love Icon Set. The collection contains more than sixty love icons in a variety of sizes, resolutions, file and color formats, and represents
Black Toolbar Icons Sometimes, the best icons can seem to go unnoticed by users, as their intuitive connection with a certain function or option makes for a fluid user experience. Our generic toolbar icon set easily achieves these goals, yet the smooth styling and modern feel
Arm Whois Arm Whois is an efficient utility, designed for network administrators and computer security professionals. Arm Whois provides correct and fast retrieval of all country information for an IP-address or hostname, allocated IP-address blocks and other networ
48x48 Free Object Icons Having the perfect icon for the function or option at hand can add significant ease to your development process, but it's also a great way to ensure your users have the best experience possible. Finding a standard icon set for a basic program is often a fa
iPhone Style Toolbar Icons iPhone Style Toolbar Icons closely mimic the original Apple iPhone icons, allowing Windows developers to produce applications and Web sites that look and feel authentic to all Apple fans. The unique iPhone look and feel is easily within reach! iPhone Style
Free Business Desktop Icons Free Business Desktop Icons is a collection of 10 free icons for use in commercial and personal products, including software applications, websites, blogs, and presentations. This icon collection will give an up to date look to all your products without ma
Large Buffet Icons Large Buffet Icons is a collection of royalty-free icons that includes a wide variety of images related to cooking and restaurant and hospitality business. It includes icons representing various meals, drinks as well as images of restaurant staff. Each ima
Blue Toolbar Icons Sometimes, the best icons can seem to go unnoticed by users, as their intuitive connection with a certain function or option makes for a fluid user experience. Our generic toolbar icon set easily achieves these goals, yet the smooth styling and modern feel
Standard Christmas Icons Do you have to stay in the office for most of the day and therefore just can't feel Christmas coming? Don't worry, now you can get Christmas right into your computer! Standard Christmas Icons represent everything that is typically associated with Holiday S
32x32 Music Icons 32x32 Music Icons collection is a set of royalty-free icons which had been specially designed to breathe a new life into toolbar of any music editing or musical device control application. All icons are developed by professional designers and present the b
Transport Icons for Vista Transport Icons for Vista is a set of first-grade icons dedicated to traveling, the globe and different types of vehicles. In this collection, you will find plenty of fine icons related to tourism, as well as icons for all sorts of transport, including big
Free WP8 Icons Free WP8 Icons is a pack of over 130 royalty-free icons for Windows Phone 8 systems. Produced to match and exceed the design guidelines for Microsoft Windows systems, this collection of application bar icons includes 48x48 pixels images with a transparent
Large Time Icons Large Time Icons set contains icons for all the types of clock, wrist watches, and time measuring devices you can imagine. This set had been professionally designed to provide bright colored matching icons for any software or Web project. Large Time Icons
App Tab Bar Icons for iPhone Here is an App Tab Bar Icons for iPhone collection, which will help each iPhone or iPad application developer get his graphic user interface in order. The icons from this set can be used in navigation, tab bars and toolbars, as they specifically meet the i
Free Red Button Icons The Free Red Button Icons is a huge collection of high-quality menu icons created by professional artists. The range of topics covered by the collection is extremely wide: file operations, disk browsing, document editing and processing, data management, im
Icons for Windows and Web Icons for Windows and Web is an ultimately comprehensive collection of top-quality interface icons that will be a perfect fit for any modern website, online service, mobile or desktop application. The set covers a number of common topics: basic OS operatio
USA-IC Icon Set USA-IC is a smooth icon set, containing 93 icons for Windows (.ICO format). It comes with 6 sizes, 1616, 3232, 4848, 6464, 128128 and 256256 pixels. There are 256-color icons (for old Windows versions) and full-color transparent icons (for Windows XP and V
Android Status Bar Icons A great Android apps should be complemented with icons that help users enjoy app functionality while presenting an attractive, uniform appearance. Android status bar icons can be some of the most difficult to find or create when development standards are h
Toolbar Icons Pack Get Professionally Styled Toolbar with Toolbar Icons Pack.
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Supported Operating Systems:
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Windows Software - Free Windows Downloads, Apps, Games, Freeware, Skype, Media Player, Antivirus, Gimp, Live, Starter for Windows XP, Vista, 7, 8, 10

domain: design


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In the 1820s, London was filling up with dead people. Graveyards were full. Corpses were breaking through the topsoil, literally. Something had to be done – and life would have been very different for the Beautiful People of Primrose Hill had Thomas Willson's vision been realised. They'd have had to find another chi-chi corner of the capital to colonise.
As the architecture writer Jonathan Glancey discovered in Tuesday's instalment of the fascinating Unbuilt Britain, a five-part look at construction schemes that never got off the ground, Willson's grand design was a pyramid-shaped mausoleum occupying 18 acres of Primrose Hill, 94 storeys high and final resting place of five million. As Catherine Arnold, who's written about it, told Glancey: "I don't think he'd studied structural engineering to any great depth."
It keyed into the Egyptomania that was trending at the time, but public response killed it off. Instead we got garden cemeteries like Highgate and Nunhead, for which we weekend city walkers are truly thankful.
In Evita's Odyssey, BBC reporter Linda Pressly focused on one cadaver in particular. After a state funeral, Eva Peron's embalmed body was spirited away by the military and hidden for a few years, fetching up in a Milan cemetery before being laid to rest back home in the 1970s. Even in death Eva had an iconic power (for once "iconic" isn't being misused), revered by Peronists and feared by the military rulers. Before Italy, her body was stashed in various locations round Buenos Aires, including behind a cinema screen – and according to legend, wherever she was moved to, however secret, flowers and candles would mysteriously appear.
The stories were fantastical: one Colonel Morricone reportedly kept her in his office to show to visitors, but became erotically obsessed and went bonkers. And when Juan Peron received her body from Italy, his third wife Isabel supposedly slept next to it to absorb the energy. It seemed to work: when Juan, restored to power, died, Isabel – a former nightclub dancer – became president of Argentina. Perhaps David Cameron should spend a few nights in the graveyard of St Martin's Church in Bladon. It's where Winston Churchill's buried.


NA 2010: Repair damaged rack without unloading product
Capable of fitting any manufacturer's rack system, a turnkey rack repair kit fixes damage to uprights and columns from forklifts and other materials handling equipment.
in the NewsState of Logistics 2016: Pursue mutual benefit California’s ports may face new political pressures during “Peak Season” CEMA forecasts 7.5% growth in conveyor industry for 2017 Schneider National officially rolls out IPO U.S.-NAFTA freight up again in January, reports BTS More News
NA 2010, slated for April 26-29, will showcase more than 500 exhibits and include a comprehensive educational conference. The event, held at the I-X Center in Cleveland, will offer an array of products to help improve productivity at your company.
Capable of fitting any manufacturer’s rack system, a turnkey rack repair kit fixes damage to uprights and columns from forklifts and other materials handling equipment. The kits come in three versions: straight leg, slant-back and set-back. They may be used to replace damaged frames and weakened columns without unloading the rack. Universal frame repair kits feature double-boxed horizontal and diagonal bracing and a full-length, heavy-gauge rear channel that completely engages the rear column. Column repair kits incorporate standard double-column construction and optional internal reinforcing structures.
Ridg-U-Rak, 866-479-7225, http://www.ridgurak.com, Booth 2605.
Subscribe to Modern Materials Handling Magazine!Subscribe today. It's FREE!
Find out what the world’s most innovative companies are doing to improve productivity in their plants and distribution centers.
Start your FREE subscription today!
Lawson Products: Automation that fits Lawson’s multi-purpose distribution center View More From this Issue


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20 Feb 2020 Newcastle rapper Simba Shore releases debut single ‘Exposing Me’
Simba Shore has just released his first-ever music video called ‘Exposing Me’.
The Newcastle artist took to GRM Daily with a laid-back set of visuals to showcase his fast-moving and silky flow. The bars are easy to digest and by the end, a wheel-up only feels like a natural conclusion.
It would seem the track was already well-received among his hometown of Newcastle. He posted a video of himself performing the song live at Jungle in Newcastle, and the crowd were singing along passionately. The track also received radio play at BBC Music Introducing, a station aimed at profiling the best new artists of the moment.
Look out for Simba Shore and what’s got coming next, because if ‘Exposing Me’ is anything to go by, it will definitely be worth the wait.
Watch Simba Shore – ‘Exposing Me’ below:

domain: celebrity


To hire a PR firm or not to hire a PR firm? An age-old question. Companies, large and small, rely on having good reputations. PR firms promise you exactly that. They advocate on your behalf through paid, earned, and owned media. PR firms help businesses spread the word about themselves, but they are not a great fit for everyone. Here are five reasons why start-ups should seek alternatives to PR firms.
1) It is expensive
It can be very, very expensive to hire a PR firm. One of the reasons the price tag is so high is that PR firms charge retainers. Retainers are fees that PR firms charge every month for a set period of time. Retainers are not project-specific, they could stretch out over long periods of time, and PR agencies charge them even if they are not actively doing anything. They can range from $1,200 up to $20,000 per month. Even though PR agencies that charge by the hour or by the project (e.g. a press release, local TV coverage, radio coverage) do exist, they can get pricey as well. For example, $500 for a press release might not be much for a large firm but could quickly overwhelm a bootstrapped or early-stage start-up.
2) Traditional media is not as influential anymore
Many PR firms have now expanded to encompass social media in their arsenal of PR tools. However, not all PR firms have adapted to the shift in people’s media preferences. With social media coming center stage, it is time for brands to become more critical of where and how they want to be noticed. If the app that you created is meant to improve the mental health of teenagers, do you really need a spot on TV? Or radio coverage? Or would it be best to focus on TikTok or Instagram, and appear as a guest on relevant podcasts?
3) Inefficient use of time
As mentioned above, PR firms often charge retainers, even for the months when no actual work gets done. They are human-intensive and rely on people to do all the work, with little to no automation. This sets them up for slow, inefficient work. Larger firms have the luxury of being able to wait out these draughts of no publicity, but start-ups cannot afford to do this. Startups need to move quickly and a month of inaction can have dreadful consequences. The pace of PR firms simply does not match up to the pace of start-ups.
4) PR could be done in-house
No one knows your start-up, your industry or your clients, better than you do. Start-ups often have granular audiences, which outsiders simply cannot wrap their heads around. People that work at your start-up are the experts on your audiences and are more likely to come up with content that resonates with them. Therefore, startups should consider having a team member manage their PR, or purchase a PR tool, such as EllisX.
5) Use PR tools instead
In 2021, we are incredibly lucky to not be limited to just two options of either doing PR in-house or hiring a PR firm. Various tools and technologies that bridge the gap between pure outsourcing of PR and having full control of it in-house have sprung up over the last couple of years. For example, we at EllisX have built a software that displays available speaking and media opportunities and allows start-ups to connect directly with journalists, podcasters, and event organizers. It is a great tool to have in your arsenal, if you do not want to be tied to a PR firm.
It is important to remember that PR firms could be a great option for some companies, but they might not suit others. They are not a one size fits all, and that’s why we at EllisX believe that startups could benefit from having more control over their exposure with PR tools, that help bring PR in-house.


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Eat. Play. Love.
On Saturday Aug. 18, 2018, animal shelters across the country are teaming up with NBC and Telemundo stations for the fourth annual Clear the Shelters event, a nationwide pet adoption initiative.
Anxiety issues can be detrimental to your dog’s health. A holistic treatment plan utilizing CBD oil has been shown to be a beneficial for dogs with anxiety.
Raw dog food has been gaining in popularity, but is till a hotly debated topic. There is no doubt that there are numerous benefits to raw feeding for both you and your dog. Learn how to best create a raw feeding plan and where to get the best ingredients.
Hiking is a great form exercise for you and your dog. Dog boots are a worthwhile investment to protect your dog’s feet from rough terrain.
We are excited to launch a new product called the Adventure Leash Ultralight! Weighing in at only 2.5 oz, this is our lightest leash ever.
CBD oil for dogs has been shown to be a safe and effective treatment for a variety of ailments. Find out more about the benefits of CBD and where to buy it.
Hiking is an amazing activity which almost anyone can engage in with the correct timing, place and gear. These 3 tips will help you and your dog master the trails off-leash.
Choosing the right dog food for your pup can be a daunting task. With so many different brands, formulas and types of dog food on the market today, it can be hard to select the optimal choice to suit both your dog’s needs and your own.
Every one loves a good wiener pic, right? Keep your pants on… we’re talking about Dachshunds here! Follow these awesome Dachshund Instagram accounts for your daily dose of #dachshundlove and cuteness overload.
Petoji is now on Etsy! Celebrate our Grand opening with 30% savings!

domain: pet


A domestic dispute ended in charges against the involved man and woman.
Chatham-Kent police responded to a disturbance at an apartment in Wallaceburg early Tuesday morning.
tap here to see other videos from our team.
Police allege a 34-year-old man of no fixed address threatened his ex-girlfriend, a 34-year-old Wallaceburg woman.
The man also reportedly threw items over the balcony, damaging cars in the parking lot below, police said.
An investigation revealed the woman was bound by conditions not to communicate with the man and to notify police of any change in address.
Police said the man was charged with uttering threats, as well as break and enter and mischief over $5,000.
The woman was charged with two counts of failing to comply with her release conditions.
Both were taken into custody pending a bail hearing, police said.
A 30-year-old Tilbury man is facing two counts of uttering threats in connection to an incident on Monday night.
Chatham-Kent police said the accused went to a Tilbury home and threatened two acquaintances.
Police were called, and the man was arrested a short time later. He was later released with an Oct. 9 court date.
A 24-year-old Chatham man was taken hospital with injuries that were not life threatening after being involved in a single-vehicle crash early Monday night.
Emergency crews responded to the collision around 6:30 p.m. on River Line between Communication Road and Harwich Road.
Chatham-Kent police said the crash occurred when the man lost control of his vehicle and left the roadway striking a hydro pole. The man was taken to the Chatham-Kent Health Alliance to be treated for his injuries.
Police said the damage is estimated at $4,000 and the crash remains under investigation.


A huge turnout is expected for the funeral of a popular Doncaster doorman who took his own life in Cambodia.
Carl Kendall, 39, died last month and his funeral will take place on Friday after a massive fundraising campaign to pay for the cost of bringing his body back to the UK.
The bodybuilder was a well-known face as a doorman on the doors of Doncaster's pubs and clubs but had endured a long battle with mental health and depression and was found dead in a hotel bedroom on the Cambodian island of Koh Rong on May 30.
READ MORE: Tributes after Doncaster dad who battled depression found dead in Cambodia
The service will take place on Friday from 4pm at Rose Hill Crematorium followed by drinks afterwards at The Salutation pub on South Parade.
Last weekend, two memorial events are were staged to Carl who leaves a teenage daughter and a four month old grandson he had never seen.
READ MORE: Memorial events held for Doncaster dad found dead in Cambodia
More than 20 doormen took part in the Doncaster's Strongest Doorman contest with money raised going towards the £16,000 cost of Carl's repatriation flight and funeral.
And a music night was also held at Carter's Bar on Cleveland Street featuring X-Factor finalists Carla May Wainwright and Samantha Atkinson.
Carl had battled with mental health issues and depression for nearly 20 years following the death of his mum in 1997.


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Did you stay up to watch the Olympics last night JUST to catch the new Star Wars: Rogue One trailer? You bet, I did! Lucasfilm’s Rogue One, takes place before the vents of Star Wars: A New Hope and tells the story of unlikely heros who have united to steal plans to the dreaded Death Star! Check out the new trailer:
The cast includes Felicity Jones, Diego Luna, Ben Mendelsohn, Donnie Yen, Jiang Wen, Mads Mikkelsen, Alan Tudyk, Riz Ahmed, and Forest Whitaker. ROGUE ONE is directed by Gareth Edwards, produced by Kathleen Kennedy, Allison Shearmur, and Simon Emanuel, executive produced by John Knoll and Jason McGatlin, and co-produced by John Swartz and Kiri Hart.
Visit the official ROGUE ONE: A STAR WARS STORY website
ROGUE ONE: A STAR WARS STORY arrives in theaters everywhere on December 16th!


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Anyone looking to become an Radiology Technician know that Pulse Radiology is the best school for Online CT Programs in Bernardston Massachusetts. All of our programs are board approved so trust that at Pulse Radiology you can strive to boost your job from a radiology technician to an MRI technologist in 14 weeks. We offer all our online training in New York, New Jersey, Rochester, Arizona, and Maryland, now, we have grown to include Massachusetts. Any of the path you pick, whether it is MRI training or CT training, they are all great programs, which can lead to a successful career. Selecting the best school where you will to take your Online CT Program is the first move; here is where your actual journey begins. We all know that the possibility of success in your job search rests on your skills but more significantly your education. This is why you must choose a trustworthy and approved school to begin your MRI technology class.
The mayor job of a Radiologic Technologist is to prepare the patient through the imaging process. The patient reclines inside the large duct of the MRI machine then radio waves create soft hints that makes cross-sectional imagings which are then used by general practitioners to diagnose medical conditions. Occupations like this, MRI Technologist, are generally found at hospitals. But now, as these diagnostic equipment become more affordably priced, other jobs like these will be offered at hospitals and imaging places. So, before you run to Yahoo.com in search of MRI courses keep in mind that PulseRadiology.com is making these options available to Everyone everywhere, through their Online MRI Technologist Programs in Bernardston Massachusetts. Complete their online courses and advance your career options. If you have questions about how to sign-up visit our website today.
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domain: medical


I have a Smitadin, and I have to say, The Gnasher is NOT the best smiting weapon. At least, imo. It's too slow. I'd have to say it's all about + skills. Getting about +6-8 skills (4 from weapon/shield, 2 from ammy, other +'s tarn and/or SoJ(s)) will achieve you 1.1k to about 1.3k Smite damage. Not too shabby. Look around for a +2 (Insert fast weapon here) 40% IAS. Although the Gnasher looks sexy at first sight, it really insn't. Also, going vs barbs is damn hard. I've never beaten a WWer.