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Folic Acid: The Effect on Male and Female Fertility
If you’ve been researching fertility supplements, you’ve almost certainly come across suggestions for folic acid. Folate (folic acid, as it is called in supplement form) is a B vitamin required to create red blood cells and DNA synthesis, and Folate is also required for cell division. Low folate levels in the blood are connected with a specific kind of anemia.
Folic acid is unquestionably a necessary component of the body. However, may folic acid aid in conception? Should guys take folic acid as well? Should you use a supplement, or can you meet your nutritional requirements via food alone?
Common names for Folic Acid
Vitamin B9 is known by many different names worldwide, but the most common name the vitamin is referred to in Australia is Folic acid. Below are some of the other common names for folate you might come across
- Vitamin B9
- Vitamin M
- Tetrahydrofolic acid
Male Fertility and Folic Acid
Folic acid, or folate, is a well-known need for women of reproductive age. (See below for further information on female fertility and folate.) However, may folate help male fertility? We require an egg and sperm before we can create an embryo.
While women are born with all of their eggs, men’s bodies produce sperm daily. Indeed, every second, 1,500 new sperm cells are “born.”
The transformation of a germline stem cell into a sperm cell takes around 70 days. Folate is a necessary nutrient for cell division and DNA synthesis.
Folate levels in sperm have been linked to sperm count and sperm health. According to one research, reduced folate levels in the sperm were related to decreased sperm DNA stability. As a result of this, we may deduce that folate is critical for sperm health.
Sperm Count and Supplementation
Could supplementing with Vitamin B9 help you increase your sperm count?. According to one research, folic acid and zinc supplementation for 26 weeks boosted total sperm count in viable and subfertile males. Indeed, it raised the average total sperm count by 74%.
Additionally, this research discovered that, prior to supplementation, seminal folate and zinc levels were not substantially different between fertile and sub-fertile males. This may imply that supplementation was beneficial even when folate deficiency was not the cause of low sperm counts.
While the study is continuing, it seems as if there is a link between folic acid and sperm health. On the other hand, folic acid is not a “cure-all” for severe instances of male infertility.
Separate research examined the effects of folic acid and zinc supplementation in males with oligoasthenoteratozoospermia (OAT). OAT is characterised by low sperm counts, unusually poor motility (sperm movement), and a low fraction of properly shaped sperm.
This research discovered that supplementation with folate and zinc had no discernible effect on these men’s sperm health.
How much should you take if you opt to supplement?
How much folate do I need to improve my fertility?. To increase your sperm quality, the recommended dose of folic acid is 400mg either by supplement or by increasing folate in your diet. If you decide to take a supplement with Vitamin B9 either by a multivitamin or by taking a “male prenatal” vitamin
We recommend taking Conceive Plus Men’s Fertility Support as it is a well balanced male prenatal vitamin: This male prenatal has been designed with reproductive health at the forefront. This prenatal is highly recommended since it includes folic acid in addition to zinc, vitamin C, vitamin D, selenium, L-Arginine and L-Carnitine, all of which have been shown to promote male fertility.
Female Fertility and Folic Acid
Women who do not consume an adequate amount of folic acid are at an increased risk of having a baby with a neural tube abnormality. When we examine how a fetus begins—a single cell that divides endlessly—it seems reasonable that folic acid may assist in ensuring proper cell division and hence proper prenatal development.
Spina bifida, anencephaly, and encephalocele are all examples of neural tube abnormalities that occur in around 4.6 per 10,000 each year in Australia. At best, these congenital malformations may result in permanent incapacity; at worst, they can result in premature death.
If you have a family history of neural tube disorders, your chance of having a kid with one of these birth problems is increased even more.
While Vitamin B9 cannot completely prevent certain birth abnormalities, it has been observed that supplementing with folic acid before conception and during early pregnancy may reduce the risk of these congenital disabilities by up to 60%. (For further information on supplements, see below.) Additional potential advantages of folic acid supplementation include the following:
- A decrease in the likelihood of congenital heart abnormalities
- Reduced risk of preterm delivery and low-birth-weight newborns
- Increased progesterone levels and a decreased risk of infertility
There are several reasons why women who are attempting to conceive should ensure they are getting adequate folate.
Folic Acid-Rich Foods
Due to the link between folate deficiency and birth abnormalities, the majority of bread and cereals in Australia are fortified with folic acid, which has led to a 14% drop in Neural tube defects. Enriched cereals and pieces of bread are probably the simplest methods to increase your folic acid intake.
Daily Recommendation For your information, the recommended daily consumption of folic acid is as follows:
- 400 mcg for males and 400 mcg for women 14 years and older, 500 mcg for nursing mothers
- Pregnant women should take 600 mcg. 400 mcg to 1,000 mcg daily is advised for women who are attempting to conceive. If there is a family history of autism or developmental delays, your doctor may suggest a more significant dose of 2,000 mcg daily.
Apart from your daily bowl of fortified cereal, here are ten folic acid-rich foods:
- Four spears cooked asparagus: 89 mcg
- 0.5 cup raw avocado: 59 mcg
- 85 grams beef liver: 215 mcg
- Half a cup cooked black-eyed peas: 105 mcg
- 0.5 cooked broccoli: 52 mcg
- Half a cup boiling Brussels sprouts: 78 mcg
- 1.0 cup shredded Romaine lettuce: 64 mcg
- 0.5 cup boiling spinach: 131 mcg
- 1 cup raw spinach: 58 mcg
- 0.5 cup cooked white rice: 90 mcg
Supplements with Folic Acid
Despite cereal and bread fortification, the majority of women still do not consume enough folic acid. Due to the fact that many pregnancies occur unexpectedly and this vitamin must be there prior to conception, the Australian National Health and Medical Research Council (NHMRC) advises that all women of reproductive age take a daily supplement containing at least 400 micrograms of folate.
The recommended daily dose of Vitamin B9 is increased to 600 mcg when pregnant. Your doctor may prescribe taking a prenatal vitamin or a daily multivitamin while you are trying to conceive. Simply verify that the multivitamin includes at least 400 micrograms of folic acid.
If you have a family history of neural tube abnormalities, your doctor may prescribe that you take between 4,000 and 5,000 micrograms of folic acid daily. Due to the fact that these levels exceed the suggested maximum limits, you should only take this high dosage under the guidance of a physician.
Daily Consumption Is Critical
Folic acid is a water-soluble vitamin, which means that it must be replenished in the body on a regular basis. To get the finest benefits, take your supplement on a regular basis. According to one research, the effects of folic acid supplementation were not seen when taken twice a week or less.
Folic Acid Supplementation Risks
There is such a thing as too much of a good thing. Unless directed otherwise by a physician, your daily supplements should not include more than 1,000 mcg of folic acid.
Taking excessive amounts of Vitamin B9 may mask a vitamin B-12 deficiency, which may result in permanent harm if not detected early. Before starting you on high-dose folate pills, your doctor should check your B-12 levels.
Additionally, there is the worry that large amounts of folate may actually impair sperm DNA synthesis.
Folic acid may have an adverse effect when used with other drugs. Folic acid, for example, may impair the efficiency of the anti-seizure medication phenytoin. Additionally, several fertility mixes include herbs that may interfere with reproductive medications. Therefore, consult your physician before commencing any supplements.
Vitamin B9 is a critical nutrient for men and women alike. Consuming an adequate amount of folic acid may help reduce the chance of birth abnormalities and may boost men’s sperm count.
They manufacture fertility pills for men and women attempting to conceive, but not all of them are created equal. Some may include substances that are hazardous to your health, interfere with medications you are already taking, or even be dangerous. Before initiating supplementing, always see your doctor, and keep your health care team informed of any vitamins, herbs, or other supplements you are taking.
Folic acid studies have shown to increase sperm concentration significantly & when taking Folic acid lowers the risk of early miscarriage

domain: biology


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- Leininger, Theodor, et al. Show all 6 Authors
- Water, air, and soil pollution 2018 v.229 no.11 pp. 373
- dissolved oxygen; eutrophication; magnesium; nitrate nitrogen; pH; river deltas; rivers; sodium; spring; summer; surface water; total nitrogen; total phosphorus; water quality; watersheds; winter; Gulf of Mexico
- ... Assessment of surface water quality in the Mississippi Delta is essential to quantify the eutrophication of the Gulf of Mexico. This study estimated the characteristics and variations of surface water quality at three study sites in the Big Sunflower River Watershed (BSRW) within the Mississippi Delta using Kruskal-Wallis, Dunn, Mann-Kendall, and Pettitt tests. In general, contents of some water q ...
- Leininger, Theodor D., et al. Show all 6 Authors
- Journal of hydrology 2018 v.563 pp. 363-371
- General Circulation Models; United States Environmental Protection Agency; air temperature; climate; data collection; environmental assessment; environmental protection; hydrologic models; nitrate nitrogen; orthophosphates; pollution load; rain; rivers; summer; water quality; watersheds; Mississippi
- ... A vast amount of future climate scenario datasets, created by climate models such as general circulation models (GCMs), have been used in conjunction with watershed models to project future climate variability impact on hydrological processes and water quality. However, these low spatial-temporal resolution datasets are often difficult to downscale spatially and disaggregate temporarily, and they ...
- PubMed Central:

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Brampton Engineering Inc. (BE) today announced that they have sold their third Aquafrost® (water quenched) multi-layer blown film line in 2013. The company now has four customers, in four different regions of the world, with multiple AquaFrost® lines. This sale also represents the 17th sale of the AquaFrost® solution since its introduction to the market. Along with this latest sale, BE has also sold a number of its multi-layer AeroFrost® (air cooled) blown barrier film lines in 2013.
The commercially proven AquaFrost® blown film line rapidly quenches the blown film in a water bath, preventing the formation of crystalline structures. The resulting film has gloss and haze qualities that are superior to those achieved with a cast film process, making it ideal for retail packaging and medical applications. In tests undertaken in partnership with leading resin companies it was proven that this type of film has many advantages over both conventional blown and cast films; including excellent tensile strength, elongation characteristics and puncture resistance. BE pioneered this remarkable innovation in the industry, and continues to invest in the AquaFrost® solution, recently introducing a number of innovations that increase productivity, and therefore the return on investment on an AquaFrost® blown film line.
AquaFrost® blown film performs significantly better than cast film for thermoformed packaging; not only does the film have improved clarity and gloss, it also offers enhanced softness and higher puncture resistance. Furthermore, our customers see improved economics due to very low scrap rates and superior production rates. The high gloss finish and ease of conversion to bags and pouches makes the film highly attractive to the food industry.


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Holi, the vibrant festival of colors, transcends geographical boundaries and cultural divides. Every year, millions across the globe come together in a riotous explosion of colors, laughter, and revelry. But what exactly makes Holi so captivating? Why does this seemingly simple act of throwing colored powder resonate with people from all walks of life holi festival celebration?
A Tapestry of Traditions: The Many Meanings of Holi
Holi’s allure stems from its multifaceted nature, weaving together a rich tapestry of cultural and religious significance. Here are some of the reasons why people worldwide embrace this joyous holi festival celebration:
- Celebrating Spring’s Arrival: Holi marks the end of winter and the beginning of spring, symbolizing new beginnings, fertility, and the triumph of life over dormancy. In a world often grappling with change and uncertainty, Holi offers a welcome respite, a chance to embrace hope and renewal.
- A Triumph of Good Over Evil: Rooted in Hindu mythology, Holi commemorates the victory of good over evil. The legend of Prahlad, a devotee of Lord Vishnu who defied his evil father, King Hiranyakashyap, resonates with the universal yearning for justice and the ultimate victory of light over darkness.
- A Time for Forgiveness and Reconciliation: Holi fosters a spirit of forgiveness and reconciliation. The playful throwing of colors transcends social barriers and allows people to mend broken relationships, forget past transgressions, and start afresh. The phrase “Bura na Maano, Holi Hai” (Don’t get offended, it’s Holi) exemplifies this spirit of letting go and embracing harmony.
- A Celebration of Community and Unity: Holi transcends religious and cultural boundaries, bringing people together in a shared experience of joy and merriment. It’s a time for families, friends, and even strangers to connect, shed inhibitions, and celebrate the spirit of community.
- A Feast for the Senses: Holi is a sensory overload in the best way possible. The vibrant colors, the sweet delicacies like Gujiya and Thandai, the rhythmic beats of dhol drums, and the infectious laughter create an unforgettable experience that leaves a lasting impression.
Beyond Borders: Holi’s Global Appeal
While deeply rooted in Indian culture, Holi’s vibrant spirit has captivated hearts and minds across the globe. The festival is now celebrated in various countries, including the United States, Canada, the United Kingdom, Australia, and many more. This widespread popularity can be attribute to several factors:
- Universality of Themes: The core themes of Holi, such as celebrating new beginnings, fostering forgiveness, and rejoicing in community, resonate with people of all backgrounds and cultures.
- A Celebration of Diversity: Holi embraces inclusivity, welcoming people of all faiths and ethnicities to participate in the festivities. This inclusivity fosters a sense of belonging and acceptance, making it a celebration everyone can enjoy.
- A Gateway to Indian Culture: For many non-Indians, Holi serves as a window into the rich tapestry of Indian culture. The vibrant colors, lively music, and joyous spirit provide a unique opportunity to experience the essence of India.
The Enduring Legacy of Holi
More than just a festival, Holi is a powerful symbol of joy, unity, and hope. It serves as a reminder that even in the face of differences, we can come together to celebrate life in all its vibrant colors. As the world throws itself into the joyous chaos of Holi, it’s a beautiful testament to the human spirit’s ability to find joy, connect with others, and embrace the beauty of new beginnings.
What is Holi and why is it celebrated?
- Holi, also known as the Festival of Colors or the Festival of Love. Is a vibrant Hindu festival celebrated in India and by Hindu communities worldwide. It signifies the triumph of good over evil, the arrival of spring, and the end of winter. It’s a time for people to come together, forget differences, and celebrate with joy and color.
How is Holi celebrated?
- Holi is a two-day festival. On the first day, a bonfire is lit, symbolizing the burning of the demon Holika. The second day is the main day of celebration, where people throw colored powder (gulal) and water balloons at each other, creating a joyous and colorful atmosphere. Singing, dancing, and feasting are also common practices.
What is the significance of the colors in Holi?
- Each color in Holi has a specific meaning. Red symbolizes love and prosperity, yellow represents happiness and optimism, green signifies new beginnings and nature. Blue represents calmness and truth.
What are some things to keep in mind when participating in Holi celebrations?
- It’s important to be respectful of others’ traditions and boundaries. Use organic and natural colors whenever possible, as some synthetic colors can be harmful. Be mindful of water usage, especially in areas facing water scarcity.
Where can I learn more about Holi?
- You can learn more about Holi through various sources, such as online websites, libraries, or documentaries. Talking to people who celebrate Holi is another great way to gain firsthand knowledge and insights about the festival’s traditions and significance.

domain: sociology


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Upper Cook Inlet’s commercial fishing season has been relatively slow so far, but it will likely pick up speed soon.
The earliest commercial fishing in Upper Cook Inlet begins in May, with the northern district set gillnet fishermen. Drift gillnet fishermen in the Central District and some east side set gillnet fishermen started in late June, with the East Forelands and the Kenai sections opening for the first time on Monday. Up through July 12, all the commercial fishermen together had landed about 671,614 salmon, according to Alaska Department of Fish and Game harvest data.
The vast majority of that is sockeye salmon — about 587,452 sockeye had been landed as of July 12. However, one anomaly this year is a large number of chum salmon showing up in the drift gillnet catch — 50,786 fish, according to Fish and Game data.
There aren’t a lot of chum salmon caught in Cook Inlet in general, as compared to other areas of Alaska. This is the largest harvest of chums in the drift gillnet fleet since 1996, said area management biologist Pat Shields.
“It’s the highest catch since then,” he said. “We don’t have any stock assessment programs where we enumerate them, other than in Chinitna Bay … They are almost all chum salmon headed to the Susitna River or to the (Cook Inlet) west side drainages.”
Thursday was the first period that drift gillnet fishermen were out in Drift Area 1, an area in the middle of Cook Inlet between Kalgin Island and the Anchor Point Light. Shields said he’d gotten some early reports from fishermen that Thursday would be their best day of the season so far.
It’s still too early in the run to say whether the sockeye salmon forecast will be accurate, but so far, everything is looking normal, Shields said. Indications from the Anchor Point Offshore Test Fishery, an experimental Fish and Game-operated fishing boat that samples fish passing into Cook Inlet, marked several large days of passage, but it’s hard to say when those fish will reach the rivers, he said.
“We’re sitting in a good position right now, everything is about what you would expect right now,” he said. “Everything does appear normal with the projected size of the run.”
The Kenai River’s sockeye sonar has recorded about 115,605 fish as of July 12, with daily passage rates ranging widely between 5,000 fish and about 20,000 fish in the past week. The Kasilof River, which always has a smaller run than the Kenai, has seen about 120,157 sockeye past the sonar as of July 12, with daily passage rates ranging between about 2,500 fish and nearly 6,000 fish for the past week, according to Fish and Game data.
It’s still early in the season. Mark Powell, owner of Alaska Salmon Purchasers in Nikiski, a processor that works only with setnetters, said fishermen had brought in several drop-offs during the Thursday period and it was mostly sockeye, as it usually is. Catches will probably pick up relatively soon as the run swells, he said.
“It’s slow, but we’ve had good seasons that started this slow,” Powell said.
Prices started higher early in the season — ranging between $1.50 and $2 per pound for sockeye, depending on the processor — and have since fallen, as they usually do when more fish reach the market. Prices at the dock varied depending on how the fish were kept but hovered around $1.50 per pound for sockeye.
Shields said the managers were projecting the runs to both rivers to meet their escapement goals and possibly toward or over the upper ends, and were comfortable using the additional commercial fishing hours allowed in the east side setnet fishery this week. An emergency order issued Thursday extended drift gillnet fishing in the expanded Kenai, Kasilof and East Forelands sections, known commonly as the corridors, until 10 p.m. He said the commercial fishermen would likely have an additional fishing period Friday or Saturday as well.

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Thursday, August 5, 2010
Hiroshima 1945, Hiroshima 2010
This is Hiroshima today.
By Alan Caruba
It was sixty-five years ago, August 6, 1945, and the anticipation of the end of the war in the Pacific swept across America when the news that an atomic bomb had been dropped on Hiroshima, Japan. Surely they would surrender, but there was no response from the Emperor or Japanese high command.
A second atomic bomb was dropped on Nagasaki six days later. And still we waited! Finally, on August 15, Japan announced its acceptance of an unconditional surrender. That avoided what military experts of the time estimated would be casualties in the hundreds of thousands if the U.S. had been forced to invade.
By May of 1945 the allies had defeated Nazi Germany and secured its surrender. What followed was the division of Europe as the Soviet Union seized control of its Eastern bloc nations. They would remain under its oppression until it finally collapsed in 1991.
Japan would be occupied by the United States and its allies until September 8, 1951. On April 28, 1952 Japan regained its status as an independent nation. Japan would go on to become an economic powerhouse.
History has been re-written since 1945 to depict the United States as the aggressor, as a wicked nation that used atomic bombs in war. The destruction of Hiroshima is depicted as evidence of some moral flaw in the American character. That is hogwash.
The United States had done everything it could to avoid going to war with Japan and only what it could to aid Great Britain that had already been at war with Nazi Germany from 1939 after the invasion of Poland began World War Two. At the time, the Soviet Union was an ally of Germany.
In Asia, Japan had invaded Manchuria in 1931 and China in 1937. On December 7, 1941, a sneak attack on Pearl Harbor launched America into a two theatre war, the Pacific against Japan and the Atlantic against the Axis powers.
The use of the atomic bombs ended World War II. By then much of Europe and much of Japan had been bombed to rubble. By then millions had died throughout the world as the conflict raged in various nations.
Since then, the awesome destructive power of nuclear weapons has deterred a global war, though America engaged in smaller deadly conflicts in Korea, in Vietnam, and in Iraq.
Until September 11, 2001, the American homeland had not been attacked since Pearl Harbor, sixty years earlier. The American response in Afghanistan was conventional warfare with no hint or suggestion of nuclear weapons. The wars conducted against the most aggressive nation in the Middle East, Iraq, were fought with conventional weaponry.
The generation that lived through and fought World War II is now passing from the scene. Those who fought in Korea are old timers and those who fought in Vietnam are men in their fifties and sixties.
Whatever else will be said at the ceremonies marking the bombing of Hiroshima, generations born since must be told they asked for it. The day they attacked America was one Franklin Roosevelt said “will live in infamy.”
August 6, 1945 was not infamous. It was necessary.
August 6, 1945 did not end the war with Japan. It took a second bomb to do that and, even then, the warmongers argued among themselves for several days whether to surrender. In the end, the destruction of Hiroshima and Nagasaki set Japan free to pursue peace.
A new generation of Americans must be reminded and must understand that America does not start wars. It ends them.
© Alan Caruba, 2010
Posted by Alan Caruba at 12:43 PM
Labels: Atomic bombs, Hiroshima, World War Two
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Interesting piece Alan, One small typo though - it was 1939 not 1938. Sorry, you lot didn't come in until 1941!
In March this year in Hiroshima I stood in front of the Peace Museum looking at the Atomic Dome and talked to an "official" tourist guide who was with us for nearly three weeks.
She told me with what I can only describe as a mixture of shyness embarrassment humility and sorrow that only as a result of having to answer questions from tourists when she took the job at the age of forty six did she learn why America dropped the bombs. Prior to that all she knew or had been told was that they had done so.
My questions about what is taught to Japanese school children had led us to this point.
She was visibly upset and I could think of nothing to say. My inadequate reaction was to briefly hold her hand.
Forgive but don't forget I understand. But not forgive and forget.
Evidently some of the earlier generations need to know that America ends wars, not starts them. I just had a horrid conversation with a man who thinks America is an imperialistic power, and that we maintain military presence in order to create an empire.
Looking at the ceremony from Hiroshima on CNN and BBC, today, and seeing all those serious faces, I feel little sympathy for Japan. All the hand-wringing and tears seem somehow misplaced.
Instead, I am reminded of the utter barbarity with which they conducted thier unprovoked invasions in Asia; the cruelty practiced by way of all manner of people-murdering systematic acts in China from December 1937, in a determination more than equal to Hitler's and Stalin's efforts and ending with the estimated death of 19 million non combat Chinese persons.
Eugenics on a grand scale
Where are the tears, hand-wringing and rememberance ceremonies for those poor Chinese souls and their survivors? Do we see any on CNN, BBC?
Let alone all the other nationalities that suffered so badly at the hands of the Japanese.
How they conducted their death-dealing can be well compared to a Medieval Islamic horde - only worse. At the time of WW2 the Japanese were of a medieval mindset. It took the 'Boys' to begin the true civilization into the 20th century of the Japanese and in the error of their ways.
The US should offer no apology for August 6th 1945 because it was fully justified and the deaths incurred in no way measure up to those incurred by the Japanese on their campaigns and what boodbath would ensue if the US invaded the Japanese mainland
The Japanese have yet to be seen to make their apologies to all those whose blood in which they are drenched, although they have gone a little way towards reparatins in some Asian countries.
To forgive is a human condition and should be exercised, but as we know, to forget is not possible and nor should it be. I mean, the Crusades are still a bone of contention within Islam as are the Armenians with Turkey. We should be joyful that the Japanese are now ex-medieval and were protected from Chinese wrath by a large US presence and allowed to develop and prosper and enter into the larger international brotherhood of nations. However, that the Japanese schooling is distorting the truth about their past should be exorcised and truth accepted by them.
In the meantime, constant reminders of all attrocities should be put before new generations to remind them of the ever-present capability of man's inhumanity to man.
Clive in the Philippines
"those who fought in Vietnam are men in their forties and fifties."
Alan, I don't mean to be picky, but you may have intended to say 'men in their fifties and sixties'. I doubt anyone who fought in Vietnam is under 50 at this time.
The corrections have been duly noted and made.
Thanks for this post, Alan.
If my dad was still alive today (he fought in WW II) and heard about Obama's apology tours and the awfully distorted history being spewed by the progressive left, he would be furious!
To those who left comments distorting history and blaming America for World War II, be advised this blog does not post idiots and ingrates.
Interesting article and pictures at Free Republic making the case that socialism American style causes more lasting damage to a city than the atomic bomb.
A TALE OF TWO CITIES HERE
I think Clive Graham Smale said most of what needed to be said. I will say this though...to see the horrors the people suffered is bound to touch the heart of every descent person, but the horrors that would have occurred if an invasion had taken place would have been far worse. It is hard to for many to accept this, but those two bombs saved millions and millions of civilian lives. Lives the Japanese hierarchy would have willing sacrificed. The Japanese elite were the monsters of Nagasaki and Hiroshima....and that is the real history.
The way I see it Mr. Caruba, is dropping those bombs ended the war. I don't like the fact that people got killed, but they had their own rulers who brought it upon them. I refuse to really play a blame game- the Emperor and Military leaders brought it on, and they realized painfully what happens when America "bites" back. It ended the war. If they hadn't have done what was necessary, how many millions of those on both sides would have died in more years of fighting? War stinks, and people die in war-we didn't ask for it, but we answered.
God Bless all the men and women who fought and are still fighting, and God bless our allies, which inculde Japan. God Bless you too Mr. Caruba
Certainly, the additional death toll for the Japanese would have been counted in the millions, had the US not utilized atomic bombs.
Gen. Douglas MacArthur said, "Have a good plan, execute it violently, and do it today." He was a brilliant general and was, without doubt, correct.
My observations of history tell me that when a nation not at war sues for peace, that nation soon finds itself at war. When a nation prepares for war vigorously, and makes it clear that it will go to war if necessary, peace breaks out all over.
At times, however dreadful war can be, it becomes time to give war a chance.
Si vis pacem, para bellum.
The Romans understood this simple principle.
If you want peace, plan for war.
Alan - speaking of "warning signs", do you have an authoritative source for that image? It appears in a hoax chain letter with other images, which according to a website which debunks these things, is in fact the wealthy port city of Yokohama (http://www.joewein.net/hoax/hoax-hiroshima-64-years-later.htm)
If it is Yokohama, then it is in error. I assume that Hiroshima, however, has been rebuilt since then.
It's not true. The U.S. has been using small nuclear weapons all over the middle east since the Gulf War. They call them nuclear "tipped" weapons, but they are solid uranium.
There are tons of reports outside of the U.S. media that chronicle our continued use of nuclear weapons whenever we invade another country.
There are lots of first hand descriptions of U.S. vehicles firing weapons in the distance and people instantly flying apart and melting. Leaving public buses wall-papered in human flesh, brains and blood.
We in the U.S. are in complete denial of the morons who continue to take turns running our country. Do most Americans play along with the fake, misinformed and uneducated people who lie, cheat and steal their way into power, just to feel normal about their lives?
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domain: history


text: Results 1–10 of 92 for "Review"X related to "APA Dissertation Research Awards and..." Refine Your Search Refine Your Search TopicTherapy (16)Children (7)Lesbian, gay, bisexual, transgender (5)Trauma (4)Parenting (3) 15 more... [+] Bullying (2)Pain (2)Sex (2)Sexual abuse (2)Women & men (2)Aging (1)Autism (1)Death & dying (1)Depression (1)Emotional health (1)Hypnosis (1)Race (1)Sport & exercise (1)Teens (1)Violence (1)Hide detailsDocument TypeReviewXYear2014 (1)2013 (2)2012 (7)2011 (16)Author/ContributorRothschild, Louis (4)Stafford, Mark (3)Tasso, Anthony F. (3)Auerbach, John S. (2)DeMattos, Susan (2) 68 more... [+] Pharis, Mary E. (2)Reynaga-Abiko, Geneva (2)Tessman, Lora Heims (2)Zelan, Karen (2)Ahbel-Rappe, Karin (1)Ainslie, Ricardo (1)Anastasi, Anne (1)Basseches, Harriet (1)Bernstein, Jeanne Wolff (1)Bishop-Towle, Wandajune (1)Bonanno, Shelley Galasso (1)Charles, Marilyn (1)Clements, Marcelle (1)Corn, Andrea (1)Corn, Andrea S. (1)Devinney, Helen (1)Downing, David L. (1)Eigen, Michael (1)Eisold, Barbara (1)Fine, Harold (1)Goldsmith, Marcella Tarozzi (1)Grand, Sue (1)Hall, Jane (1)Harris, Judith (1)Hartman, Stephen (1)Hegeman, Elizabeth (1)Helm, Fonya Lord (1)Himes, Mavis (1)Hollwitz, John (1)Kaley, Harriette (1)Kalish, Beth (1)Karen, Maroda (1)Kenner, Jane (1)Kimmel, Douglas (1)Knoblauch, Steven (1)Knowlton, Kathy (1)LaMothe, Ryan (1)Lewis, J. Scott (1)MacGillivray, William A. (1)Masling, Joseph (1)Mills, Jon (1)Moss, Donald (1)Naso, Ronald C. (1)Newman, Marilyn (1)Nierenberg, Ona (1)Novie, Gregory (1)Rabate, Jean-Michel (1)Raubolt, Richard (1)Reis, Bruce (1)Ridenour, Jeremy (1)Russell, Glenda M. (1)Ruth, Richard (1)Schulman, Martin A. (1)Silverstein, Charles (1)Stolorow, Robert D. (1)Strenger, Carlo (1)Suchet, Melanie (1)Tabin, Johanna Krout (1)Takooshian, Harold (1)Tasso, Anthon F. (1)Tejirian, Edward J. (1)Thurer, Shari (1)Waugaman, Richard M. (1)Waugman, Richard M. (1)Webster, Jamieson (1)White, Kathryn (1)Wilson, Jessica E. (1)Winn, Martin (1)Hide details Results 1–10 of 92 Previous 1 2 3 ... Next Relevance Title A-Z Title Z-A Newest First Oldest First Sort by: 1.Review of "Psychological Testing" by Anne AnastasiA 1954 review of this volume described it as a consideration of the principles of psychological testing, which employs examples of tests of general classification, aptitude and achievement, and ends with measures of personality characteristics ranging from inventories through projective techniques and situational tests. Review 2.Practice Procedures (Book Review)One of the books is geared toward helping early career psychotherapists develop a successful psychotherapy practice, and the other is thoroughly grounded in the analytic method to treat panic and anxiety.Review (January 2012)3.Our Emotional Makeup: Ethnopsychology and Selfhood (Book Review)In this work, we are taken on an historical and philosophical journey about how emotions have been theorized and researched in a way that is meant to control and maintain the status quo. Despret has written a convincing text about the exclusion of culture and the continued oppression of certain people throughout time.Review 4.Traumatic Bereavement, Attachment, and Thoughts on Prevention (Book Review)Barbara Gerson reviews a book edited by Beatrice Beebe, Phyllis Cohen, Mark Sossin, and Sara Markese that explores the selective prevention program known as the Project for Mothers, Infants, and Young Children of September 11, 2001.Review 5.The Brain That Changes Itself: Stories of Personal Triumph From the Frontiers of Science (Book Review)Doidge takes the reader by the hand and carefully explains that the brain can and does change throughout life. Contrary to the original belief that after childhood the brain begins a long process of decline, he shows us that our brains have the remarkable power to grow, change, overcome disabilities, learn, recover, and alter the very culture that has the potential to deeply affect human nature. Review (January 2011)6.Under the Skin (Book Review)This book is unique as an in depth psychoanalytic study of body modification, and needs to be recognized and commended for its insightfulness and the comprehensive integration of psychoanalysis with cultural studies, literature, art and film.Review (January 2011)7.Group Treatment of Adolescents in Context: Outpatient, Inpatient, And School (Book Review)This book described as being down-to-earth and user friendly for both the analyst and non-analyst, acknowledges the sad reality that most outpatient treatment centers have undergone significant internal changes as financial reimbursements have superceded patient needs.Review 8.The Collapse of the Self and its Therapeutic Restoration (Book Review)David Downing's review describes this book, which is organized into three related progressive dialogues, as one that is bound to become an important touchstone for those interested in theory as well as clinical practice.Review 9.Primary Process Thinking: Theory, Measurement, and Research, Volume I (Book Review)The author explores theories concerning primary and secondary process thought, and lays out a lucid empirical path to study issues long mired in the conceptual realm, from condensations to displacements.Review 10.Advanced Hypnotherapy: Hypnodynamic Techniques (Book Review)Anthony Tasso's review of John Watkins' and Arreed Barabasz's book. The book demonstrates the continuing strength of the relationship between hypnosis and psychoanalysis.Review Previous 1 2 3 ... Next Relevance Title A-Z Title Z-A Newest First Oldest First Sort by: ADVERTISEMENT Results 1–10 of 92 for "Review"X related to "APA Dissertation Research Awards and..."

domain: library


If most of us had our way of doing things, we’d have home-cinema-wide screens in our houses to sit back and relax as we watch them. But sadly, reality is often far from fantasy.
Many of us cannot afford the space nor the price to have an ultra-gigantic screen to mount on the wall. But that doesn’t necessarily mean that we can’t enjoy vibrant colors, immersive sounds, and cinematic experiences otherwise.
We’re here to tell you that you can have an astonishingly stunning experience with nothing more than 46 inches of screen width.
Top 4 Best 46 Inch TVs
1. Sony BRAVIA KDL46EX720 46-Inch 1080p 3D LED HDTV
First up on our list is the Sony BRAVIA KDL46EX720 46-Inch 1080p 3D LED HDTV. This bad boy has so much to offer in its small case. It delivers an amazing 3D experience thanks to the full HD, sharp, and vivid pictures produced by Sony’s unique X-Reality Engine.
The TV also features Motion Flow XR 240 for a unique experience when watching action-filled movies and shows. Add all that to the 120Hz refresh rate, and you’re bound to get a smooth and flawless watching experience.
To make things even better, whenever you get fed up with cable TV, you can switch to the World Wide Web as Sony’s BRAVIA KDL46EX720 allows access via Wi-Fi to multiple apps from the likes of YouTube, Hulu, and Netflix besides the ability to surf the net through a built-in browser. The Skype video call compatibility feature is just the cherry on top.
The input ports are versatile enough to connect both old and new devices. From composite and component ports to several HDMI and USB ports, this 46-inch TV is ready for anything you may throw at it.
Relatively lower price? Sure, but you can take advantage of that spare cash to treat yourself to some movies and games and experience them in the way they should be experienced, on a screen of this caliber.
- Classy design
- 3D experience
- Affordable price
- Many connectivity options
- Clear, sharp, and vivid pictures
- Several settings to adjust the TV to your preferences
- The browser isn’t that great
- The sound, although good, isn’t up to the pictures’ quality
2. Sharp AQUOS LC46LE700UN 46-Inch 1080p 120Hz LED HDTV
Of course, at least one entry on the list has to be from Shark. And although Shark is known for being one of the top dogs on the TV market, that doesn’t mean that they don’t produce quality screens at reasonable prices. One example is the Sharp AQUOS LC46LE700UN.
Although it’s not a smart TV nor an internet one, the Sharp AQUOS LC46LE700UN delivers excellent value as it comes with Sharp’s best LCD technologies, including the infamous Full Array LED backlight and the Ultra Brilliant LED system that ensure longevity, lightweight, and low power consumption. And the XGen LCD Panel tech delivers deep dark and clear bright colors.
As for the speed, this TV can deliver a 4ms response time, classifying it among the fastest in this category.
Now, as great as this would be as a TV on its own, you may be having other ideas in mind, like using it as an oversized PC monitor because, why not? Yes, this screen comes with a PC input port alongside the four HDMI slots.
So if you’ve ever wondered how it would feel like to take the power of a gaming rig and hook it up to a relatively big 46-inch monitor, now’s the time to answer that question. Besides that, you also get a USB Photo Viewer, AQUOS Net, and RS-232C Input.
Of course, you can place this TV however you want, in an entertainment center or hung up on the wall. At the end of the day your eyes will be pleased and your wallet too.
- Affordable price
- Excellent pictures and rich colors
- Full Array LED and Ultra Brilliant LED System
- The built-in speakers aren’t that great
3. Sony KDL-46HX729 46″ LED HX729 Internet TV
Yeah, this is the second Sony TV that we have to recommend, no surprise there. But this one is particularly aimed at movie buffs. And for a 46-inch screen TV, a movie buff won’t find anything to top it.
First of all, the TV set packs an ambient sensor and two digital video processors for adjusting the quality of the image according to the ambient light. So, whether you’re into classics or the hottest blockbusters, this TV will deliver the quality no matter what.
This is another affordable TV, so know that you’re getting all the apps and the internet goodies, including Netflix, Amazon, and Hulu. Besides that, we’ve got crisp image quality and vibrant colors thanks to the Dynamic Edge LED backlight, which is complemented by the smoothness of the Motion flow XR 480 technology.
What we dig about this TV is that it can double as a gaming monitor. Just connect your console, and you’ll get an unbeatable experience when it comes to 3D gaming. A TV that fits movies and gaming enthusiasts and that comes at an affordable price. What else could you ask for?
- Affordable price
- Great for movies, games, and internet browsing
- Motion flow XR 480 technology for crisp pictures
- The sound is not the best on the market
4. Sony BRAVIA KDL46EX640 46-Inch 1080p LED Internet TV
Another great model from Sony. The KDL46EX640 46-INCH 1080p Internet TV comes with support for Dolby Digital, Digital Noise Reduction, and not two, not three, but four HDMI ports. Talk about connectivity, huh?
Besides that and the slick and slim design, this TV set stands out because of the Motionflow XR 240 Technology and the Clear Resolution Enhancer, both of which guarantee a crisp image no matter what you’re using the TV for.
Needless to say, this is a Wi-Fi-ready, Internet TV, so you’ll get access to all the online fun such as YouTube, Netflix, and Hulu.
- Affordable price
- Multiple connectivity options
- Fantastic display with vivid pictures
- Internet-ready, and loaded with online apps such as Netflix
- The remote can be annoying
For 46-inch TVs, all of the TVs listed here are winner picks. Whichever you decide to go with, you’ll be very pleased and satisfied with what each has to offer.
At the end of the day, it all comes down to how much you’re willing to pay and what you want exactly out of your screen. So, make your choice and have no worries.


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Mains Cables R Us have developed an external audio grade power supply for the Cambridge Audio DACmagic D/A converter. Available in silver or black the power supply is made in the UK and is not a mass produced chinese box of tricks. The casing has an IEC inlet on the rear to accpet a mains lead (one is provided) and a captive DC lead to connect to your DAC.
The design will filter out any mains noise and provide your DAC with a clean supply thus improving performance, proven by existing customer feedback. The dacmagic is powered by 12V AC so does not require a regulated linear PSU, just a good filtering system and a steady voltage stream.
Our power supply’s have been awarded 5 stars by Hi-Fi Choice in a recent review (squeezebox touch linear psu).
Customer Review below..
I have spent the last 2 weeks listening to the new Dac Magic power supply and I have to say it is brilliant. More detailed, greater space, sweeter at the frequency extremes and a pleasure to listen to. Nicely put together as well and one of the most cost-effective upgrades I have made.
Top notch service too – thanks very much.

domain: design


BURNEY, Calif. — A pair of wildfires burning without restraint about 8 miles apart in northeast California became the focus of state and federal firefighters Sunday as authorities reported that one of the blazes had destroyed eight homes and prompted the precautionary evacuation of a small long-term care hospital.
The two fires, among 14 burning in the state, started within a day of each other in Lassen National Forest and had expanded into private property and scorched 90 square miles as of Sunday morning, up from 39 square miles a day earlier.
The more destructive of the two was threatening the town of Burney, where officials at Mayer Memorial Hospital decided to evacuate their 49-bed annex for patients with dementia and other conditions requiring skilled nursing. The patients were transferred to a hospital in Redding, about 55 miles away, the hospital reported on its website.
The Shasta County sheriff had Burney on an evacuation watch after ordering residents of three small neighboring communities to leave on Saturday night. Sgt. John Greene said the area is sparsely populated and that authorities did not yet know how many residents were affected or if the destroyed homes were vacation houses or permanent dwellings.
Evacuations also remained in effect for a community on the edge of the second fire, which was sparked by lightning Wednesday.
The two blazes were among 14 that federal, state and local fire crews were tackling on Sunday in central and Northern California, state Department of Forestry and Fire Protection spokesman Dennis Mathisen said. Together, they have consumed more than 183 square miles of timber and brush left parched by the state’s extended drought, Mathisen said, adding that the coming week promises not to be any easier.
“Today we are looking at slightly cooler temperatures, but Northern California continues to be hot and dry and breezy in some areas, and in fact we are looking at a fire weather watch going into effect Monday morning for a large portion of Northern and northeast California and possible thunderstorms, which could mean more lightning,” he said.
The number of fires led California Gov. Jerry Brown to declare a state of emergency Saturday. His proclamation said the circumstances and magnitude of the wildfires are beyond the control of any single local government and will require the combined forces of regions to combat.
Siskiyou County, which borders Oregon, also was contending with two major fires, both started by lightning last week. One of them, which began in Oregon, threatened hundreds of structures and charred 51 square miles in both states, including 14 square miles on the California side. It burned three homes and other structures, and evacuations remained in place for several neighborhoods in both states.
Federal fire officials said that along with working to protect homes, one of their priorities was to safeguard a water station that supplies the city of Yreka. Brown secured a federal grant to cover 75 percent of the cost to fight the blaze.
Meanwhile, federal officials asked residents in two communities southwest of Yreka to start preparing to evacuate because of advancing flames from a cluster of blazes that had charred 8.6 square miles by Sunday afternoon.
An additional 150 structures remained threatened and subject to evacuation orders in Modoc County near the community of Day, where a lightning-sparked blaze that started Wednesday had torched 20 square miles.
In Washington state, a wildfire that started during a lightning storm Saturday night burned several structures, authorities said. North of that blaze, firefighters contained another wildfire that started Friday and burned six to eight homes.
GAZETTE COVERAGEEnsure access to everything we do, today and every day, check out our subscribe page at DailyGazette.com/Subscribe
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Take a disturbing and violent trip though 80s Miami
Hotline Miami is a retro, top-down arcade game, where you play an unnamed character who is sent on murderous missions in 80s Miami. It's very challenging, and while it's extremely violent and disturbing, it's one of those rare games that makes players question what they are doing.
- Excellent sound and graphics
- Compelling and addictive gameplay
- Great storyline
- Occasional glitches
Best Hotline Miami downloads

domain: game


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NNkeka, born to a Nigerian father and a German mother and managed by Neverland Music & Martin Schuhmacher has a new album coming out.
Concrete Jungle is her third album, but her first US release. Her first US release, Concrete Jungle is a collection of songs that put the singer/songwriter at the forefront. Every year since her musical career took off in 2005, this Afro-German warrior princess has built on her successes, stretched her muscles, and widened her range. Her debut album Victim of Truth (released in the UK in 2007), an inspirational mix of hot loops, black consciousness and 21st-century soul music – was garlanded with praise by the British media. ‘As good as The Miseducation of Lauryn Hill,’ said UK’s The Sunday Times.
Nneka Egbuna was born in Warri, Oil City in the Delta region of Nigeria at the height of its new found wealth in the mid 70s.
For nineteen years she soaked up the sounds and rhythms of one of the most musical nations on the planet, a country where expressing yourself through song is just a part of everyday life, a country that has music in its very DNA, where the influence of giants like Afrobeat revolutionary Fela Kuti is never far away.
But at the age of 19 this modest and hard-working young girl made the big decision to leave behind the African way of life. To further her education, she moved not just to Europe but to Northern Europe, to the industrial seaport of Hamburg in Germany. For the young Nneka, it was a dramatic change, and there remains an intangible quality in her voice that speaks of being a long, long way from home.
“The cultural differences between Germany and Nigeria were extreme,” she says. “The way they dress, the way they carry themselves, their religion. So many things that were important to me are not important to them. For two years I was overwhelmed.”
For all its innate musicality, Nigerian culture perhaps prizes education higher than any other achievement, and while Nneka was making her first demos and beginning to make waves as a performer, she was determined not to waste the stack of A-levels that she already had under her belt. Enrolled at Hamburg University, she continued to study for a degree in anthropology – no mean feat when you’re in demand at clubs and festivals from Paris to Lisbon, from Vienna to Madrid.

domain: artistic


text:
Get Your Game Room Ready with a Donkey Kong Neon Sign
— Get Your Donkey Kong On with a LED Neon Sign for Your Gaming Room
Elevate your gaming room decor with a Donkey Kong Neon Sign! Our high-quality neon sign will add a retro touch to your space while showcasing your love for classic video games. Crafted with attention to detail, our neon sign will add a vibrant glow and nostalgic flair to your space.


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An affordance is a quality of an object, or an environment, that allows an individual to perform an action. The term is used in a variety of fields: perceptual psychology, cognitive psychology, environmental psychology, industrial design, human–computer interaction (HCI), interaction design and artificial intelligence.
As explained below, two different definitions have developed. The original definition describes all action possibilities that are physically possible; a refinement to that definition describes action possibilities of which the actor is aware.
Affordances as action possibilities
Psychologist James J. Gibson
originally introduced the term in his 1977 article The Theory of Affordances
and explored it more fully in his book The Ecological Approach to Visual Perception
in 1979. He defined affordances as all "action possibilities" latent in the environment, objectively measurable and independent of the individual's ability to recognize them, but always in relation to the actor and therefore dependent on their capabilities. For instance, a set of steps which rises four feet high does not afford the act of climbing if the actor is a crawling infant. Gibson's is the prevalent definition in cognitive psychology.
Jakob von Uexküll had already discussed the concept in the early twentieth century, calling it the "functional colouring" (funktionale Tönung) of objects.
Affordances as perceived action possibilities
In 1988, Donald Norman
appropriated the term affordances
in the context of human–machine interaction
to refer to just those action possibilities which are readily perceivable by an actor. Through his book The Design of Everyday Things
, this interpretation was popularized within the fields of HCI
and interaction design
. It makes the concept dependent not only on the physical capabilities of the actor, but also their goals, plans, values, beliefs and past experience. If an actor steps into a room with an armchair and a softball
, Gibson's original definition of affordances allows that the actor may throw the recliner and sit on the softball, because that is objectively possible. Norman's definition of (perceived) affordances captures the likelihood that the actor will sit on the recliner and throw the softball. Effectively, Norman's affordances "suggest" how an object may be interacted with. For example, the size and shape of a softball obviously fits nicely in the average human hand, and its density and texture make it perfect for throwing. The user may also bring past experience with similar objects (baseballs, perhaps) to bear when evaluating a new affordance.
Norman's 1988 definition makes the concept of affordance relational, rather than subjective or intrinsic. This he deemed an "ecological approach," which is related to systems-theoretic approaches in the natural and social sciences. The focus on perceived affordances is much more pertinent to practical design problems from a human-factors approach, which may explain its widespread adoption.
Norman later explained that this adaptation of the term had been unintended. However, the definition from his book has become established enough in HCI that both uses have to be accepted as convention in this field.
Consequences of the duality of the term
Norman's adaptation of the concept has brought about the use of affordance
as an uncountable noun, referring to the property of an object or system having easily discoverable action possibilities, as in "this web page has good affordance," or "this button needs more affordance."
It has also caused many to use the verb afford, which Gibson's original term was derived from, in a way that is not consistent with its dictionary definition. Rather than "to provide" or "to make available", designers and those in the field of HCI often use afford as meaning "to suggest" or "to invite".
The different meanings now associated with the word, although closely related, can be a source of confusion in writing and conversation if the intended meaning is not made explicit and if it is not used consistently. Even authoritative textbooks can be inconsistent in their use of the term.


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Download Platters Ringtones


Mysuru, Aug 8 (IANS): Congress leader and leader of opposition in Karnataka Assembly Siddaramaiah on Monday slammed the RSS and BJP, and dubbed the ambitious flagship programme of the ruling BJP 'Har Ghar Tiranga' campaign a farce.
Veer Savarkar, the icon of BJP had opposed the tricolor flag. Savarkar is being worshipped by RSS. The magazine "Organizer" known as the mouthpiece of BJP had opposed the national flag in the present form. When they had opposed the tricolor then, how are they coming up with 'Har Ghar Tiranga' campaign now? Is it not a farce? Siddaramaiah stated.
BJP does not respect the constitution, national anthem and national flag. The celebration of the 75th year of Independence is being turned into a political event, he said.
"The Congress is celebrating the occasion with respect and honour as it is the Congress which brought independence to India," he said.
The BJP in Karnataka is scared. Even one week after my birthday celebrations they have not stopped talking about it. The party has decided to take up 75 kilometers of padayatra in all districts and taluk centers to mark the occasion, he said.
He further stated that it is the Congress which had fought for the country. Jan Sangh took birth in 1951. Do they (BJP and RSS) know about the freedom struggle? he wondered.
Did any RSS leader go to prison for their struggle for Independence? Were Sangh founders Hedgewar and Golwalkar jailed for freedom movement? Siddaramaiah asked.
After the BJP came to power, the imports from China have gone up and exports have come down. The Make in India initiative should have increased exports from the country. There is no meaning for the initiative if everything is brought to India from other countries, Siddaramaiah stated.


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The AveXis announcement ushers in a new and exciting era of clinical trials that attack the root cause of Rett Syndrome. Without a lot of precedent with gene therapy just yet, it’s hard to know what FDA will require and what the development timelines will look like. In my last blog we discussed the road to FDA approval. In this blog let’s focus on how pharmaceutical and biotech companies plan a development program and design that first clinical trial in patients, something AveXis is working on right now.
Drug development is expensive and risky. Traditionally, it also takes a long time. Not to be a downer but overall less than 10% of new drugs make it all the way from their first human study to FDA approval; a journey that typically takes 10-15 years. Gene therapies are expected to provide much greater therapeutic benefit and therefore improve these statistics.
What else do we know about traditional drug development? We know that it costs many millions of dollars to conduct clinical trials in a drug development program. In fact, depending on the number of studies, the number of patients, the number of sites and their location, it can cost many, many, many millions of dollars.
Let’s do a thought exercise about starting a clinical development program. Put on your traditional drug development hat and let me ask: how would you proceed in designing your first patient clinical trial?
A few decisions have to be made right off the bat, with little to no human data to back it up. Before you dose a single patient, you have already selected what characteristics your trial patients should have and the number of patients to be enrolled. You have determined what scales and measures you will use to detect an improvement in the disease state. You have also decided on the doses to be used as well as the frequency and duration of dosing in the trial. That’s a lot of decisions, and all of these decisions are made before you know if they were based on the right assumptions.
And just to up the stakes a bit, you have to select in advance the “primary endpoint”, which is the key efficacy measurement designed to show the effect of your product, and upon which your study will be considered to succeed or fail. Your study can show statistically significant changes in all of the other secondary endpoints you’ve chosen, but if it fails on the primary endpoint, the study fails.
Ready to spend those millions? What if you didn’t choose your patient characteristics right, or you went too low on the dose and didn’t see enough change, or went too high on the dose and saw troublesome side effects? What if your endpoint measure wasn’t good at picking up changes in the disease? It’s rare for companies to hit all of these parameters on the nose the first time.
Many of these questions for traditional development will be easier, faster, and more straightforward for gene therapy programs. Luckily for us, AveXis can lean significantly on what they learned in their SMA program to jump start and accelerate their Rett program. Whether a traditional treatment or a gene therapy, the first patient study is challenging. Gene therapy trials should require fewer patients and fewer trials, which means faster development. Since it is only administered one time, identifying the optimal dose should also be easier.
Therapeutic development, whether gene therapy or drugs, is a huge, risky commitment for companies and not all of their decisions are easy or straightforward. Nonetheless, therapeutic development continues to the benefit of patients worldwide. We are glad for the decisions companies make and the risk they take when starting a new clinical development program, and we are excited to see how gene therapy will change that development approach.

domain: medical


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The nominations have been done. At least three of the films deal with current political conflicts (these ones):
“The Act of Killing”, Cutie and the Boxer, The Square, Dirty Wars and 20 Feet from Stardom compete for the Best Documentary Feature prize at the 86th Academy Awards on March 2…”
I have seen them all (see below) except for “20 Feet from Stardom” (Photo). “The film has this synopsis description on the Oscar site (link below): Background singers heard on many of the 20th century’s greatest songs have made a crucial contribution to the world of pop music while remaining unknown to listeners. The singers take center stage for an in-depth look at their role as supporting figures in the complex process involved in creating the finished recordings.” From watching Youtube clips and the trailer it is obvious that this is a film with wonderful music and women, based on interviews with them and people like Bruce Springsteen, Mick Jagger and Betty Midler. A classic tv language film.
So… who are my favourites having seen all five, one in excerpts? “The Act of Killing” and “The Square” stand out. No doubt about that. In film language, actuality and storytelling. Important films they are. If it comes to approach to theme, innovation and originality “The Act of Killing” is unique. It would get my vote if I was a member of the Academy. I am not.
If you want to read more about what is considered to be the two favourites, not only by me, go to the websites of the films, links below. Or get hold of the magazine DOX 100, where Joshua Oppenheimer and Werner Herzog talk “The Act of Killing” and Jehane Noujaim is interviewed by BBC-editor Nick Fraser about “The Square”. Fraser, who has called “The Act of Killing” “porn for liberals” thinks that “The Square” is “the best film I have seen this year”.

domain: politics


"No enemy will dare to give a dirty look to Iran due to the extent of the Iranian Armed Forces' readiness," Admiral Sayyari said, addressing the Navy personnel in the Southern city of Sirjan in Kerman province on Wednesday.
The Iranian Navy commander underlined the full preparedness of his forces to confront and defeat all types of enemies and under any type of condition.
Last week, Iranian Defense Minister Brigadier General Hossein Dehqan underlined the Armed Forces' capability to give a rapid and crushing response to any enemy threat.
"The Iranian Armed Forces are able to control and repel threats decisively and swiftly in accordance with their level and type," Dehqan said, addressing a gathering Iran's diplomatic corps abroad.
He also underscored the country's huge progress in the past few years in building different weapons and military equipment to defend itself.
The General Staff of the Iranian Armed Forces in a statement in May underlined intelligence superiority over enemies' moves in the region, and warned that any hostile act against the country will face a crushing response.
Using the invaluable experiences of the 8-year Iraqi-imposed war against Iran (1980-1988) and the commandership of Supreme Leader of the Islamic Revolution Ayatollah Seyed Ali Khamenei, the Iranian Armed Forces "will give a proper and crushing response to any threat, given their intelligence superiority over the enemy front's situation and moves", the statement said on Saturday.
It also described developing capacity for the country's growing defensive production and development of Iran's deterrence power as the Armed Forces' main goal.
The statement said under such conditions that the country is facing a sensitive situation, there is no doubt that the key weapon of unity and sympathy between the government and the nation would yield valuable and decisive results.


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- Steps from Madonie Regional Natural Park
This vacation home places you next to Madonie Regional Natural Park and The Madonita Ambientalistic Museum of Polizzi Generosa. The vacation home includes a kitchen, a balcony, and a living room.
The vacation home features a kitchen and a balcony. There's space to spread out with a separate bedroom, a living room, and a dining area. The vacation home also includes a coffee maker.
This vacation home is a smoke-free vacation home.

domain: travel


text:
Beauty and the Beast was my favorite Disney animated film that was produced during my lifetime. The animation, story, music, all of it was perfection. I audibly gasped when I heard that Beauty and Beast was the next in line to become re-imagined in live action. I have anxiously awaited the first peeks at what I could only hope would be just as spectacular.
These first photographs did not disappoint. Let’s just take a little picture walk shall we?
Belle and Maurice have always been #FatherDaughterGoals for me.
Lefou and Gaston are my favorite lovable villains. Fun fact – Lefou is played by Josh Gad, who just happened to voice a little known character named Olaf in a little known film called Frozen….. you may have heard of it.
Emma Watson in that iconic gold ball gown. This is the shot fans have been waiting for.
Belle in the castle, it’s just perfection.
Everybody with me….. “Noooo one fights like Gaston, Douses lights like Gaston……”
The gang is all here! Look at the adorable enchanted castle staff! Cogsworth, Mrs. Potts, Lumiere, and Babette!
And last but not least, a little peek behind the scenes. Emma Watson taking direction as they film. This movie is sure to be pure magic.
As if these first images were not enough, I also have a trailer. It’s OK to cry…..
Disney’s “Beauty and the Beast” is a live-action re-telling of the studio’s animated classic which refashions the classic characters from the tale as old as time for a contemporary audience, staying true to the original music while updating the score with several new songs.
Beauty and the Beast opens in theaters on March 17, 2017. I promise to share more as it becomes available!
All images are by Disney and used with permission.

domain: entertainment


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The Last of the Human Freedoms
As you may know I often speak to groups on how to shift their focus and way of thinking so they can live a happier existence, regardless of their circumstances. We are all aware that there are people on this planet who live in horrific conditions and experience oppression of all kinds. To suggest to any such person that they could be happier simply by choosing to shift their focus and way of thinking to the things that bring them joy might seem insensitive or ludicrous. Yet, the truth is, even amidst the most devastating of circumstances, people can make courageous choices that will allow them some degree of relief from their suffering. Let me offer up the real-life example of Viktor Frankl.
In his book, Man’s Search for Meaning, Viktor shares what he learned from his experiences as a prisoner in Auschwitz during World War II.
“Everything can be taken from a man, but one thing, the last of the human freedoms, to choose one’s attitude in any set of circumstances, to choose one’s own way.” Read that again, and consider his situation as you do. Physical and mental torture and a life seemingly with no choices.
Surrounded by total despair and devastation, Viktor chose to embrace an attitude that enabled him to, at the very least, feel better and, at times was able to experience some degree of happiness that would be unimaginable considering his personal circumstances. The actions he took to help a friend to develop his sense of humor amidst their shared tragedy resulted in providing both of them relief from their daily reality. Here’s what they did: Viktor and his friend promised to imagine and tell each other every day some amusing incident that would happen after they were liberated. This simple act of story telling developed into a sort of Cabaret improvised by other prisoners who joined in from time to time. They sang shared poems, told jokes and developed a keen appreciation for the power of satire. Many prisoners attended, despite their fatigue and the fact that they missed their daily food rations. Their participation was effective in helping them to forget, if briefly, their dire situation.
To my mind, this shows that sometimes nourishment of the soul is more important than nourishment of the body. Humor was used as a weapon in the fight for soul preservation. It is well documented that humor, more than anything else within the human ambit of understanding, can help an individual to rise above any situation, if only for a few moments.
Even if only for a few moments at a time, Victor Frankl did whatever he could to shift his focus on the things that would help lift his spirits. This simple act gave him an infallible attitude, the courage to dare to be at least happier than his circumstances dictated, and in the end was responsible for his survival.
It is my belief that we all intuitively know what Viktor understood and acted upon, that happiness is our right to choose and even our destiny. It is a calling and a yearning for a higher part of ourselves, challenging us to experience a sacred “time-out” for peace and joy, even under the most severe circumstances. Even if only for a few moments at a time. Sometimes, my friend, a few moments of that happiness is all you need to keep you from giving up.


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Welcome to our blog
Insights from our team, partnered clinicians, and leaders in the field.
This report adds detail to existing findings in wider tech sector studies that workforce diversity has stagnated, now on-par with the 1990s in relative terms within AI. We discussed the findings with Mihaela Van Der Schaar, the most-cited female AI researcher in the UK from the data set.
I dream of the day we no longer need to discuss inequalities in STEM between men and women, because they will simply not exist. That day is still too far away, resulting in a huge waste of talent and a loss to society. I want to tell you why I’m passionate about changing this situation.
The Cambridge Centre for AI in Medicine develops pioneering AI and machine learning technologies with the goal of transforming biomedical science, medicine and healthcare. Another of our goals is to bring you the very latest advances in ML for medicine, directly from the pioneers making it happen. To this end, we are excited to announce…
CCAIM Director, Professor Mihaela van der Schaar, explores the potential impacts of automated machine learning on medicine and healthcare delivery, with a message of empowerment for clinicians. Read the full story.
At the end of April 2020, CCAIM Director, Professor Mihaela van der Schaar, gave a keynote (Zoom) presentation at ICLR 2020, a key deep learning conference that draws an impressively diverse crowd of participants and speakers. She discusses key aspects of her presentation. Read the full story.
CCAIM Director, Professor Mihaela van der Schaar, explains that using AI and machine learning in medicine isn’t just about developing accurate models and rolling them out because, on their own, they are “black boxes” that are hard for their intended users to apply, understand, and trust. Professor van der Schaar presents a solution to this…
CCAIM Director, Professor Mihaela van der Schaar, calls on governments and healthcare authorities to use proven AI and machine learning techniques and existing data to coordinate a response to the covid-19 pandemic. Read the full story.


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Patricia Vargas, regional director of the SOS Children's Village, where the children are being cared for, told the AFP news agency that officials at the Haitian Institute of Social Welfare told her "most of the kids have family".
Miss Vargas said some of the older children of the group had confirmed the officials' words. Children over the age of seven said that "their parents are alive, and some of them gave us an address and phone numbers," she said.
The children are being cared for at the centre in Croix des Bouquets, a town west of the capital Port-au-Prince, which was devastated by a 7.0 magnitude earthquake on Jan 12 that left up to 200,000 dead.
The US embassy in Haiti said on Sunday that ten US citizens were being held for "alleged violations of Haitian laws related to immigration."
Earlier, Yves Christallin, the Haitian social affairs minister, said police had arrested five men and five women with US passports in a case that centres on an Idaho-based church group.
The Americans said they wanted to take the quake victims to an orphanage in the Domincan Republic.
Laura Silsby, the head of the group from the New Life Children's Refuge, said the arrests were the result of a mistake.
But Mr Christallin said: "This is an abduction, not an adoption."
The Haitian government has tightened its travel restrictions for children in the country, and said the prime minister will for the time being have to sign off on every minor's departure abroad.
SOS describes itself as the world's largest charity dedicated to orphaned and abandoned children, and has been working in Haiti for seven years.


Hello good people,
I’ve just installed cubase elements 8. I want te record my electric guitar. I’m using a m-audio fast track audio interface. Windows 10.
Allthough I set up the vst-connections (mono input, device ‘fast track’) and the ASIO-driver (fast track driver), i can see no input when adding an audio track. And I have checked that the input bus is selected (the fast track).
But no signal vissible let alone audible. In Audacity i can record my guitar using the same setup. The signal gets lost somewhere in between my audio-interface and cubase.
Anyone got suggestions? Thanks!


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Founded in 2006, iNDiViDUALS is AMFI's design-driven fashion label. Third and fourth-year students from each of three graduation specialisations work together for six months on designing, producing a collection which is communicated and marketed in collaboration with the fashion industry. Each collection is presented to the outside world and sold at selected stores in the Netherlands. iNDiViDUALS is a unique minor, no other Fashion Education programme anywhere offers this experience.
In this minor students work together to come up with and launch new fashion media brands. Students create everything: from concepts to the production of content – using writing, photo styling and art direction to translate a topic to multiple media channels. This excellence minor introduces students to every aspect of the publishing business; from brainstorming to production; from design to publication; from website to launch event. In the second half of the programme students become part of one of the newly created companies and work to share this new fashion media brand with the world. All products made are required to stand the test of the professional world of fashion publishing.
In the first phase of this minor students create new fashion photos based on inspiration by their favourite designer. In the next phase, students learn to make short fashion films. These films take as their inspiration young Dutch designers. At the end of the minor the photos will be exhibited in the byAMFI Statement Store and the films will be shown in Bioscoop Het Ketelhuis.
This 20-week minor programme offers third and fourth-year students from Design, Management and Branding the ability to focus on the world of denim. Bridging education and business, the activities build skills in craftsmanship as well as an understanding of innovation in the industry. Students should have a real interest in and passion for denim. They should see themselves progressing to work in denim development in the industry.
byAMFI is the Statement Store of Amsterdam Fashion Institute. It offers a platform to showcase the beautiful work that is made by our students, teachers and alumni. A team of second year students from all three departments designs inspiring concepts for the interior and organises events.
byAMFI is literally AMFI’s shop window in the heart of Amsterdam city centre and a place favourably visited by professionals and fashion lovers from the creative and commercial industry.


Sterlco manufactures hot oil type and hot water type mold and die temperature control units (also known as hot water, hot oil or heated oil application process control units). Commonly available are single zone, dual zone and three zone units, including 6 kw, 12 kw, 24 kw, 36 kw and 48 kw per zone. These units are also commonly used as process boiler units outside the die casting industry.
Die Cast Machinery, LLC is a dealer that specializes in second hand Sterlco temperature control units; we buy and sell Sterlco hot oil and hot water units daily. We commonly stock and can supply Sterlco temperature control units, both hot oil and hot water units in the following sizes: 6 kw, 9 kw, 12 kw, 18 kw, 24 kw, 36 kw and 48 kw. All of these sizes are available in single, dual and three zone configurations. Sterling hot oil and hot water temperature control units are commonly used in injection molded plastics, extruded plastics, extrusion, blow molding, plastic film, foundry and die casting applications for preheating and maintaining correct tooling temperature; they are extensively used by die casters to maintain die temperatures. They are also used in process industries including food processing, chemical, petroleum and pharmaceutical industries.
Inventory ID: 5561
Model M2B2012-F 12 kw Single Zone Hot Water Temperature Control UnitView Details
Inventory ID: 5584
Sterlco 24 kw (12 kw per zone) Dual Zone Hot Oil Temperature Control UnitView Details
Inventory ID: 5578
Sterlco 48 kw (24 kw per zone) Dual Zone Hot Oil Temperature Control UnitView Details
Common options and features available on temperature control units include single zone, dual zone and three zone configurations; auxiliary cooling circuits using a process water cooled heat exchanger, drain valves, hour meters, visual and audio fault alarms, low level alarm, auto-venting sequences, pressure switch for low pump pressure, process pressure gauges and reversing pumps. Voltage options include: 200, 208, 230 volt, 380, 415, 440, 460, 480 volt and 575 volt (600 volt) three phase primary power in either 50 hertz or 60 hertz.


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TO THE HONORABLE MEMBERS OF THE SENATE: I am vetoing Senate Bill 8. The bill creates an exemption from the open records requirement for security system plans for utilities. These plans could relate to physical or electronic security of utility facilities, telecommunications or information technology systems. The exemption requires a determination that the facility or system is so vital to the state that the incapacity or destruction of the facility or system would have a debilitating impact on the physical or economic security of the state or on public health, safety or welfare.
I recognize that the state's utility systems are vital to Wisconsin's security and that the intent of this bill is to ensure that security. However, current law already provides for the protection of these records without creating another exemption to the Open Records Law. The Open Records Law anticipates the need for protection of certain records and provides for an exception based on a case-by-case determination of whether a record should be disclosed, a process commonly called the balancing test. Under the balancing test, if the public's interest in not disclosing the information outweighs the public's interest in disclosure, then release of the record is not required.
The public scrutiny of government action provided by the Open Records Law is vital to maintaining the integrity of state government. During a time when national, state and local resources are focused on maintaining public security, it remains equally imperative for a democratic society to safeguard access to public records so that the public's right to know and ability to evaluate the actions of its government is not unduly hindered. I object to setting another exemption of certain records when an alternate means of protection is already in place and functioning well. Access to these records should be subject to the balancing test on a case-by-case basis to ensure that the public interest is upheld. Respectfully submitted, JIM DOYLE Governor


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“Twilight’s” Ashley Greene appears to be dating again. Greene has split from Joe Jonas due to clashing schedules. It is hard to keep a relationship going with two diverse schedules; however, all is not lost for the “Twilight” Actress.
Her representatives deny reports that Ashley has jumped ship on Joe to move some waves with Jared Followill. It did not take this beauty much time to find a replacement for Joe Jonas. According to Wonderwall, “Greene was spotted out with the Kings of Leon star the same day her spokesperson confirmed she had broken up with the Jonas Brothers hunk, prompting speculation the pair is romantically involved.” So are they just friends? The timing is at best poor.
Also, the rumor mill is busy with the gossip, but talk is that Miley may have eyes for Jared Followill, as well. Reports are that Jared received some flirtatious glances from Miley Cyrus after her “SNL” skit. So what is it? Everyone denies the gossip, but the fact is both Ashley Greene and Jared Followill have been quite cozy of late, so although Ashley’s representatives deny the relationship, the rumor mill is rarely wrong.

domain: celebrity


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Brno Female Stripper
We offer you a professional show by a beautiful stripper anywhere in Brno. We just some some private space, where show can by done (apartment, lounge, limousine etc.).
We have the best girls in Brno!
You can have more than one stripper at a time and, if you prefer, the striptease can be performed as a contactless one. Possibility to choose a costume.
- Private Strip show for 15 minutes;
- Strip show anywhere in Brno;
- Possibility to choose a costume for the lady.


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[[[[VVRSSNN]]]] (Adam of Yume Bitsu): s/t
This record is called [[[[VVRSSNN]]]] and you pronounce it like "version". Like the b-side dub remix on a reggae 45; like a version of something that happened before; an improvement, a change, a re-vision, an edit. Adam Forkner, aka [[[[VVRSSNN]]]], is a founding member of the bands Yume Bitsu and Surface of Eceon. He's also known for recording and engineering all sorts of bands at K Records' Dub Narcotic Studio, including, among others, Calvin Johnson, Little Wings, Wolf Colonel, Greg Weeks, and Kinski. [[[[VVRSSNN]]]] makes music on his computer, by himself and with his friends. Its like: guitars, sequencers, BEATS, glitches, singing. Lots of singing: songs, weird vocal loops, yeah, there's some voice on this record. It’s a little dark at times, but you won’t get too scared. It’s 21st century feel good all over music. Autumnal in all the right ways. Curl up on a couch. Drive around at dusk in the rain. Go to a dance party and feel alienated. The [[[[VVRSSNN]]]] CD/LP is for these times. [[[[VVRSSNN]]]] (KLP145) features contributions and collaborations with: Dave Longstreth, Jeremiah Green and Eric Judy of Modest Mouse, Phil Elvrum of The Microphones, Calvin Johnson, Rob Kieswetter (aka Bobby Birdman), Franz Prichard of Yume Bitsu, 9078686 (aka Y.A.C.H.T.) of The Badger King. As they say in Portland these days, “get in”.
Artwork of note: the CD version has 8 different covers and the LP covers are hand-decorated by Mr. Forkner and Friends. Bella!
Yume Bitsu: The Golden Vessel of Sound, Part 4
An official announcement from Yume Bitsu: "There are no song titles for this record. Each composition was created as improvised or barely structured music throughout their development as recordings and it feels wrong and contrived to think of words to fit them now. We have chosen to let them stand nude as sonic experiences without, and beyond, the boundaries of the written word. We suggest that you address the songs as you would if you never knew the title. The first song, therefore would be 'Song One', the second 'Song Two' and so on." Sonically, Yume Bitsu has always been a hard band to pin down. Traversing across celestial landscapes imbued with drifting, lilting sheets of ambient guitars, keyboard driven astral landscapes, in-your-face wall of fuzz and occasional harmonious soaring voice, Yume Bitsu effortlessly shift from one end of the psychedelic musical spectrum to the other, with surprisingly successful effect. Yume Bitsu's process of creation, as it has developed over the last 7 years, is as intriguing as the music it creates. They claim that they play forth from "the vessyl" a channel of energy whose output is greater than that of the individual members combined. Accordingly, their approach to creating sound has been more uniform than their output ever has. Nowhere in their ever-growing catalog is that more apparent than on their remarkable fourth full length, The Golden Vessyl of Sound.
Yume Bitsu: Auspicious Winds
Yume Bitsu: spiritual bedroom music. This is their third album, capturing the feel of the dream beats from which they draw their name. Auspicious Winds documents their latest journey through sonic time holes and hazy alter-universes. Four extended epic compositions and one yearning psyche-pop jewel (“Sharp, Twisted”) map out introspective territories, cascading through the subtle nuances of mind, body and soul. Take it and saturate the textures?


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NJ bans students from probing naked sleeping patients without consent
It could have happened to you but you might not ever know it.
Unbeknownst to most of us, medical students for years have been brought into New Jersey hospitals to conduct invasive examinations on unconscious patients without their consent or knowledge, but that’s not happening any longer.
Legislation sponsored by Assemblyman Paul Moriarty, D-Gloucester, has been signed into law that prohibits gynecologic, rectal or other exams if a patient is out cold and hasn’t given permission for this kind of procedure to take place.
They're doing what?
“I mean we’re talking about pelvic exams, invasive touching of a human body when the person is unconscious and has not consented to having multiple people use them as a human prop,” he said.
He said medical school students have given testimony admitting “they’ve been asked to practice things like pelvic exams on patients when they’re unconscious, and that’s unconscionable, and shouldn’t be allowed.”
Med students feel funny
Moriarty said he was once told by a medical student “I was asked to do a pelvic exam after the presiding doctor had already done that and then asked me to do that as well as a teaching aid, and I just felt very uncomfortable.”
He said the new law specifies “if someone is going to be poking and prodding you other than the doctor that you expect to be doing the procedure, that you have to consent to that beforehand unless it’s an emergency.”
Moriarty stressed “I don’t believe that anyone that’s unconscious wants to be used as a human prop for medical students to poke and prod them and practice their skills, I think that’s wrong and shouldn’t be allowed and thankfully this bill now prohibits that.”
Some people might not mind
He also noted “some people might want to consent to allowing students to do this in a limited capacity, because obviously medical students do need to learn, there are some places that actually hire people to come in, and pay them to let medical students poke and prod them and do exams, but nobody should have to undergo this if they’re not even conscious or aware of what is happening.”
Under the new law,A-1489 andS-1771 health care practitioners will be required to obtain informed consent prior to performing any inspection of a patient’s reproductive organs, breasts or rectum if anyone other than the doctor will be involved in the exam. The law’s consent requirements do not apply to circumstances in which the practitioner must conduct an invasive exam in order to provide necessary emergency care.
You can contact reporter David Matthau at email@example.com.


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PG Score: 7.5/10
Dark Waters is a well-made film about a disturbing true story. It centers on Robert Bilott, a corporate defense attorney (played by Mark Ruffalo) who heads up an environmental lawsuit against the DuPont chemical company. It examines the extensive history of pollution the company exposes a small town in West Virginia to, as well as the rest of the nation. It covers a timeline that spans decades of corruption, negligence, malpractice and flat out deceit by the corporate behemoth that is DuPont. Dark Waters has a lot of information to cover over a period that spans decades. As a result, it gets right into it from the start. I appreciated the fact that the film dives right into the material and builds the characters as it goes, rather than having unnecessary character development before getting into the real meat and potatoes, so to speak. This approach benefits both the viewer and the film itself. Rob Bilott is a successful attorney that specializes in corporate defense. As such, his career is based upon defending large companies such as DuPont. The fact that he ends up going after them to hold them accountable is not only noble but also makes for a very interesting dynamic to witness onscreen. Much of the film has the classic “David vs. Goliath” feel, in that Bilott is tasked with defending the “little guy” against the big, bad bully. His gradual shift from apprehension towards looking into a farmer’s claims of DuPont poisoning the water, to devoting his life to the case, is fascinating. Ruffalo does a great job of portraying the toll it takes on his character from both a career and moral standpoint. This is some of his best work and showcases his ability as a lead actor. Anne Hathaway does an impressive job as his wife, Sarah. She expertly conveys the damage the case causes her and her family and she is involved in a few of the film’s more powerful scenes. Her prowess in a serious role is on full display here. Tim Robbins plays Tom Terp, who is Rob’s boss caught in an awkward position of doing the right thing and maintaining his relations with the corporations his firm defends. Robbins delivers a strong performance and, as always, is a delight to watch work onscreen. Bill Camp’s performance as the farmer, Wilbur Tennant, is also worth noting. I really felt his pain after having his life destroyed by DuPont. This is one of the finest performances I’ve seen from him. The pacing for the first half Dark Waters is spot on. It gets right into it and really doesn’t slow down. Once we get into the later acts, things drag quite a bit. It gets pretty slow in the second act and although it doesn’t ruin the movie by any means, it definitely hurts it. Thankfully, the final act picks up quite a bit and goes a long way towards filling the void left by the slower middle portion. Dark Waters is a very good take on a very unsettling true story. While it does lose some steam in the middle, the rest of the film makes it worthy of my recommendation.


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Is organic dairy making you sick?
The FDA has recently announced the acceptance of Carrageenan in organically labeled food. Carrageenan is additive used as thickening and stabilizing agent typically found in organic dairy. Carrageenan is a polysaccharide that induces and causes inflammation in the body. For those of us with an autoimmune disease, this is bad news.
Another great reason to buy raw dairy or simply put a dairy cow in your backyard, ok, just kidding, kind of…
If you’re freaked out and need a little peace of mind about the use of raw dairy, try pasteurizing it at home yourself. It is super simple and you can choose your depth of pasteurization.
Pour raw milk into a nonreactive, non-aluminum pot and place over medium heat. Slowly heat milk to 145° stirring occasionally to make sure it is evenly heated. Hold the temperature at 145° for exactly 30 minutes. Keeping it longer than 30 minutes could result in destroying the milks protein and keeping it less than 30 minutes may not destroy any potential pathogens.
After 30 minutes, careful pour the milk into a separate pot and set it in a sink full ice water, stirring occasionally until the milks temperature drops down to 40°.
Did you know… 145° will ensure any potential pathogenic bacteria is destroyed, however, commercial dairies heat their milk to 191° which kills every organism in the milk, including the beneficial ones. If you do not care about the beneficial flora or making any home dairy products, such as, yogurt, cheese or sour cream, then you may too pasteurize it to 191° as well.
Even though I am a big advocate for Raw milk, as it contains natural beneficial flora and enzymes, sometimes having peace of mind in food consumption has a greater impact.
TIP.. Find a reputable local farmer near you to buy raw milk. Some Farmer’s will allow you to inspect their milking facilities however; others practice high bio-security and do not let visitors on the premises, as potential bacteria can be spread by foot.

domain: food


The coupling system can only be disconnected after its closure, and it is not possible to disconnect during the transfer of fluid, which increases safety and prevents failures during the process.
The existing models allow use in the most varied uses and applications such as transferring, loading or unloading vapors, petroleum products, acids, solvents and pressurized gases in pressure classes up to # 300lbs.
API couplers for liquid transfer, marketed by Redlands, are manufactured according to the strictest quality standards, incorporate the most modern in terms of technology and security in connections and meet and / or exceed the practical recommendations of API RP1004 .
Steam couplers are also manufactured in accordance with API RP1004 and are responsible for the recovery of vapors on Bottom Loading loading platforms. The use of this system for the transfer of liquids and gases reduces the emission of vapors at the terminal and contributes to the improvement of health and environmental conditions.
Dry Disconnect Couplings
Wide application in transfer and handling operations of dangerous liquids and gases, mainly in the chemical and petrochemical segments. Also available for LPG, aviation market and cryogenic products. The system consists of a coupler (female) and an adapter (male) in the same dimension for quick and secure coupling. It allows opening and flow only when coupled and its release is dry and without splashing or emitting vapors into the atmosphere. They are manufactured in the most diverse materials and seals and are available in diameters from 1 ”to 8”. Installation can be done by means of flanges or threaded connections to allow greater flexibility and meet the most diverse specifications.
Breakaway safety couplings are used to protect terminals and equipment in loading / unloading operation. In cases of accidental pulls on the equipment, reaching the predetermined breaking point, these couplings will separate and the internal valves will automatically close on both sides, eliminating the unwanted release of the product. They act as a fuse in your production line. We have several models and diameters for land and marine applications.