Walter Ricciardi, the Italian government’s scientific adviser, said that the UK should have learned the lessons of his country’s experience and gone into lockdown ten days ago. His warnings come as the UK reported 113 deaths from COVID-19 on Wednesday, the highest single daily jump in fatalities. Mr Ricciardi, who is also a World Health Organisation expert, told Sky News: "When we scientists put the evidence on your table, you should take action.
"When you take the decision late you pay a price in sick people and in deaths."
The Italian scientist drew parallels with scenes of overcrowding on London’s tube with a football match in Milan last month.
The match between Atlanta and Valencia at the San Siro stadium was attended by around 40,000 fans from Bergamo, the current epicentre of the COVID-19 contagion.
It is believed that this event ignited the coronavirus inferno, that subsequently tore through the northern Italian town.
BRITAIN is facing a worse coronavirus infection rate than Italy
Mr Ricciardi said: "When I looked at some images of the London Tube or some mass gatherings that happened when we already had the impression that this was dangerous, this was a kind of example that could have been avoided.
"Having had the example of Italy, the UK could have adopted its (lockdown) much earlier."
Italy is presently the country worst affected by the lethal virus, with over 8,000 deaths.
The high death toll is a combination of many factors, but it is mainly thought to be due to the large proportion of elderly people in its demographic profile.
The huge influx of cases in Lombardy put massive strain on the health service, which struggled to cope with the numbers of ill and dying people in what is a national tragedy.
The WHO expert thinks it will be months before there is any return to some resemblance of normality, suggesting that earliest people can expect to travel in Europe again will be the summer.
He cautioned that Britain’s delay in imposing a curfew could mean that UK residents have to endure these conditions for longer.
"I think at least one month but I guess it could be even longer," he said.
Coronavirus: Public Health England set to release home testing kits [Latest]
Coronavirus WAR: Canada urges Trump to keep troops away from border [Update]
BBC QT: Medical expert's shock blunder over virus 'national crisis' [Latest]
Meanwhile, in Italy the government has tightened its curfew measures.
Exercise is more restricted and fines have increased to €3,000 for anyone found outside with a valid reason and the right documents.
Mr Ricciardi is hopeful that Italians will not face a three month lockdown, as has been the case in Wuhan, China.
He is encouraging his government to introduce South Korean-style testing and tracking procedures to help contain future outbreaks.
These procedures include using mobile phone to monitor the movements of people and contact those who test positive for COVID-19.
Mr Ricciardi’s remarks come as a top NHS executive has said that London hospitals are facing a “tsunami” of new patients infected with the coronavirus.
Despite expanding their critical care capacities between five and sevenfold in recent weeks, Chris Hopson said that NHS executives had become alarmed at the speed at which beds are filling in the capital.
In an interview on BBC Radio 4’s Today programme, he said: “They are struggling with the explosion of demand in seriously ill patients.
“They are saying it’s the number arriving and the speed with which they are arriving and how ill they are.
“They talk about wave after wave after wave. The words that are used to me are that it’s a continuous tsunami."


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Despite currently leading the Tampa NFC South, the Tampa Bay Buccaneers have been one of the NFL’s most disappointing teams this season. Thanks in large part to the struggles of their offense, the Bucs are currently just 5-6 and are coming off of an overtime loss against a Cleveland Browns team that was well below .500 entering the game.
It has certainly not been the season the franchise would have hoped to have in the last year of Tom Brady’s contract.
Even with his stats dipping a bit this season and the team not living up to expectations, Brady will likely still garner plenty of attention if he hits free agency and decides to continue his NFL career.
Today, The Atheltic’s Jeff Howe discussed one interesting team that could be among those looking at Brady as their answer for next season. According to Howe, Brady could go back to the New England Patriots.
— Dov Kleiman (@NFL_DovKleiman) November 30, 2022
The Patriots could be one of the top contenders to land a big name to play under center during the offseason. They’ll have a ton of cap space for the 2023 season and Mac Jones hasn’t given them much reason to continue counting on him next season.
While they would be an interesting option for Brady, there are some factors that make the move somewhat unlikely. First of all, he seems to be happy in Florida. Second, Mac Jones isn’t the only person responsible for the Patriots’ offensive struggles.
When Josh McDaniels left for the Raiders, the Pats didn’t bring in an offensive coordinator to replace him dither committee of Matt Patricia and Joe Judge hasn’t gotten the job done.
The team also doesn’t have much in the way of weapons on offense with their major expenditure on tight ends not paying off and a lack of a true WR1.
At this point in his career, Brady will only be playing for teams he knows are built to compete and it’s not entirely clear if the New England Patriots will fit that description next season.

domain: news


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text: I do voice characterizations and I like to do improv (all "my" videos are improvised. Although I'm not an actor, I can take direction and develop characters. All the videos I have posted, that I did (except for Jack In The Box), are improvised-not written. Commercial voice work, narration, animation voice over work wanted! Judd or Matt (Groening and Stone)-hire me please. I'm located in Toronto,Ontario Canada It's amateur hour in the north country> Yeah I can get an agent.

domain: artistic


WEST MIDDLESEX – A borough business owner plagued with skyrocketing sewer bills got the relief he sought from council.
Last month, James Mims, owner of the Dairy Queen in West Middlesex, asked council for help with sewer bill he had received in 2019.
At the January meeting, he said his sewer bills began rising early last year because of a water line leak on his property. Mims said he hadn't known about the water leak.
As is common with sewer utilities, West Middlesex bases its billing on the amount of water a home or business uses in a month. Most of the water pumped into a borough household is eventually piped to the sewer plant before being treated and discharged back into the surface water systems.
But because of the leak in his pipe, Mims said most of the excess water never entered West Middlesex’s sewer system. Instead, it wound up in the ground under Dairy Queen’s parking lot.
Mims asked that the borough apply a $2,870 credit to his bill. The sum, he said, is far less than what Mims thinks he deserves because, even with the credit, the business still paid a figure based on double the amount of water it typically used before the leak.
The business paid the full water bill to Aqua Pennsylvania, because Mims said Dairy Queen used the water that leaked into its parking lot.
Council unanimously agreed to Mims' request on a "one-time only" credit.
Mims, who was not at the meeting, said later that he was OK with the result.
"I'm very pleased,'' he said.
Dairy Queen, 3498 Sharon Road, is closed during a renovation project. Mims said he has invested $750,000 in the shop during the renovation.
He expects to reopen by early- to mid-March.


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domain: pet


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KABELO TSOAKO is convinced his neighbours hate him. Nothing screams conviction like two EPs, unambiguously titled My Neighbours Hate Me.
“I make a lot of noise wherever I live. I can imagine how my neighbours feel,” Tsoako tells me. I can’t imagine the annoyance one would have to live through, having a music producer right next door constantly making music, often in ungodly times.
But I doubt the same “loathing” neighbours imagine that, their noisemaking makhi is one of the country’s most slept on musicians.
Being slept on is,when not a lot of people have heard your material but once they do, they’ll admit that you’re dope. Being underrated on the other hand, is when your material is out there and everybody sees you, but no one considers you dope enough to be in the top five or whatever, said a friend of mine differentiating the two.
Young, gifted artists who put in the work, are rarely celebrated which can trigger mental issues in some creatives. But it’s fruitful for one’s mental state, to learn to define self, outside of their art. “I’m probably depressed three or four times a week [laughs]…but you gotta soldier on bro. I also think this mental health thing affects every artist differently.I know I make nicer music when I’m down and it’s all about trusting the process,” the producer also known as KaeB tells me.
With material that can sit well on most urban radio stations around the world, KaeB has consistently released music, under the radar for a couple of years now. The young man from Tembisa is currently pushing his single, Crown featuring Parley Wang also from the 1632. Crown is on KaeB’s six track EP My Neighbours Hate Me II that came out earlier this year.
He’s been making music since high school days, but ever since his #Cozyfridays where he dropped a track, at the end of each working week, he’s shown growth in his music and consistency.
“…I used these releases to challenge myself to make a song in a week, come up with an artwork and drop it on Friday sort of like a drill. This helped me understand how to rollout a release. The record label/agency transition happened when I had to release a compilation tape for all the #CozyFridays and I kinda just setup my own label/agency,” says KaeB.
The Stay Cozy Group is his brainchild, but he has an external management agency for bookings and his day to day management.
Slept one as the fella is, KaeB is beginning to reap the rewards of his sweat and consistency. His bouncy track Right Now with ECHLN and EMAMKAY has been receiving warm reception from those who’ve been fortunate to hear the re-released song which he first posted on his Soundcloud in Feb this year . While just over a year ago, a track he produced C&L by Melo B Jones, was on the Kaya FM playlist-still is.
“People do like what I’m putting out; I run into people who always have positive feedback about the music. I also think being more visible on social media this year helped a lot and that’s how I connected with ECHLN to redo Right Now and put it out.”
To date he’s released three projects since his first output, the Ruh Tape in 2012. His sound has grown with the pace of pubic hair in adolescence and with the graceful evolution of a caterpillar to a butterfly. When I first came across his music, he was a Hip Hop head who cut samples that would give Boom Bap rappers wet dreams. That was in 2012. In 2016 he produced a song that warranted him airplay on Joe Kay’s show on Soulection. It was a remix of Justine Bieber’s All That Matters. They also play his music on electro music label based in Singapore, Dakerthanwax.
The evolution of his sound is a result of his maturity as a listener of music, who constantly forces himself out of any box.
The Beat Makers Market took place last month in Joburg, which KaeB didn’t attend nor participate in. He never competes in beat making/producer competitions. “[Laughs] I peeped the ‘line-up’ and it was not my type of music. I’ve outgrown that style of music. I wouldn’t even enter such an event I’ll probably lose to someone who is currently making that type of style,” says KaeB.
Melodies and harmonies are a mainstay in all his music. Listening to the first My Neighbours Hate Me EP, I couldn’t shake off the feeling that dope lyrical rappers or any other artist could richly benefit from working with a producer like KaeB. Such collaborations would also dispel notions around beat making competitions which seem to be focus on just Boom-Bab beat makers.
On the same note, you will find that artists who get on these rich soulful, futuristic bouncy beats, do not do the music justice. The feeling of the song is often prioritised over its lyrical content. A balance is needed.
On his music making, KaeB says “The process varies with the mood but I always start with my drums and then I’ll add the melodies and harmonies. I’ve also made it a habit to add a hook, mostly me singing as an idea that I can build on later on.”
Hearing beautiful music come together is a joy. That’s the reason I don’t think KaeB’s neighbours hate him. In fact, the EPs probably should’ve been called I Think My Neighbours Hate Me, because quite frankly, no one from next door has complained to his face about the noise he makes.
· Apart from him, KaeB says these are some of the producers to keep an eye on in the near future. Sheeesh. Skinniez, Tsukudu, Ctea, Tweezy, Trust B1, Benny, Wichi1080 , Enkei, Sptmbr Yngstr, Daev Martian , ECHLN, Hi-Lux, Gina Jeanz, Ben Rasco, Broken Transient, Muzi, Vthevowel and Zuks.
JUST FOUR DAYS before he was to headline Rocking The Daises and In the City festivals, it was announced that US artist GoldLink won’t be performing in the country this weekend.
“Due to unforeseen personal health reasons, Goldlink will not be performing at this year’s Rocking the Daisies and In the City festivals in Cape Town and Johannesburg. Goldlink is extremely disappointed that he won’t be playing to his South African fans this weekend but promises to return soon,” read the statement from event organisers yesterday.
Last year Solange gave a similar reason for cancelling her performance at the inaugural Afro Punk Johannesburg just days before she was to headline the festival. But unlike Afro Punk, Rocking The Daises and In the City festivals were swift at finding a suitable replacement for the Washington D.C rap singer.
The statement included that Aminé will be GoldLink’s replacement at both events. Aminé is a suitable substitute, as the two do comparable music and have a similar fan base, although GoldLink’s music has more body than Caroline rap singer Aminé.
“I was sad but I mean with GoldLink after he plays Crew, what else are we finna listen to. Most of his songs are feel music anyways. Aminé at least we got both albums with sufficient amount of jams. We have Majid Jordan to put us in our feels, please I’m not there to cry,” said Clownish Gambino on Twitter.
But as much as the announcement that Aminé would be the plan B was welcomed by some, others weren’t happy at the news. “Bathong, GoldLink just cancelled on us??? Wow,” Okay Wasabi Tweeted. “Solange and GoldLink are the reasons I have trust issues,” said Szechuan.
Rocking the Daisies takes place this weekend where the likes of 6Lack, Soulection and Mura Masa will be present in Cape Town while In the City takes place on Sunday at Emmarentia Dam in Joburg with the same artists who will perform in the Western Cape.

domain: entertainment


Volunteers for International Youth DayThe International Cooperative Alliance Asia and Pacific Committee on...Read more
Volunteers for Go Green Campaign 3.0Youth are the fore front of any entity to excel its...Read more
Book Review: A Genealogy of the CooperativeA Genealogy of Cooperation” by Mohammad Bahiraee Published...Read more
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Written by Ronah Marie Kristine Funtilon Nillos, NATCCO Youth Representative, Philippines. , 2018-07-30 11:04:41
Look around your surroundings. Tell me what you see. You can’t because all you see is garbage everywhere and this creates all kinds of pollution to our Mother Earth. We were given the responsibility to take care of nature and all we do is destroy it. We can’t do anything if nature itself makes us pay the price of our irresponsibility. This will cost us the destruction of our properties or worse our lives. This is the raging storm brought by the nature to pay our debts.
As a youth, who are the future of our generation plays a vital role in our society and the coop’s future branding. Even if we are young, we’re responsible and can be the source of change for the better. We are not just for a display for the sake of being nothing in the modern society. Youth can make a significant and outstanding action for the 21st century society. We, the aspiring youths, never back down to any problems as long as we uphold our dreams to make it a reality and serves as an inspiration to other young people. That is an immense impact we, the millennial wanted and hoped to develop.
We created a big step ahead in doing a great deed for the environment. With these environmental issues and problems are rising each and everyday and one of the major cause of the earth’s destruction especially in the environmental, economic, and health concern trends is the Global Warming. Last July 07, 2018 at Maasin Watershed Forest Reserve (MWFR) in Barangay Daja, Maasin, Iloilo under the Province of Iloilo through the Provincial Government Environment and Natural Resources Office (PGENRO) conducted a Tree Planting Activity participated by hundreds of participants from different sectors of the government, students, teachers and employees from various places in the province of Iloilo to be as one in the action for the help of our environment. In line with the celebration of International Day of Cooperatives, the Iloilo City Public School Teachers and Employees Multi-Purpose Cooperative (ICPSTE-MPC) Laboratory Cooperative Staffs and Youth Officers and the Multiple Intelligence Sequence and the High School for the Gifted students and teachers of SPED-Integrated School For Exceptional Children spearheaded the said activity by Ronah Marie Kristine Funtilon Nillos, the chairperson of the ICPSTE-MPC Lab-Coop and the NATCCO Youth Representative to join the celebration of Philippine Environment Month 2018 with this year’s theme “Beat Plastic Pollution” to support for the action for Re-greening and Transformation for Climate Change Adaption (ART-CCA).
Youth can help reduce waste by giving appropriate attention to small details in their lives via planting and growing a tree, it can contribute to the environment by providing much oxygen, improving air quality, conserving water, preserving soil and supporting the habitat of wildlife. Protecting the environment starts within each and everyone of US. You and I, we can make a better change for the world.


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Today I sent a letter to New Orleans Mayor Mitch Landrieu urging him to unite our community by focusing on murders, not monuments. The letter is in response to a racially charged email blast by Mayor Landrieu this week.
A copy of the letter from today is below:
September 4, 2015
The Honorable Mitch Landrieu
1300 Perdido Street
New Orleans, LA 70112
A friend forwarded me your mass email, attached.
I have said many times, and I repeat again, that I think you should unite our community by focusing on murders, not monuments.
114 of our fellow citizens have been murdered in New Orleans already this year. Lester Johnson was gunned down in his driveway in New Orleans East on Wednesday morning.
Rather than taking strong, bold action on the out-of-control crime problem, however, you send out a hateful email to create a distraction and play the race card. It attacks and insults not just me, but countless concerned citizens who feel as I do. That’s not leadership, it’s pure political cynicism.
Wake up, Mitch. The monuments aren’t murdering our family members and neighbors. Focus. Lead. Unite. Track down those who are.

domain: sociology


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Since our eyes are constantly peeled for fun wall art, we’re so excited to bring you this week’s giveaway from E.A.D Designs. If you are looking to personalize your space with a fabulous vinyl wall quote, than this week’s prize is right up your alley!
***This giveaway is complete & no longer accepting entries***
E.A.D Designs specializes in unique vinyl lettering designs, decals and decor for every area of your life: home, work and everything in between. Now you can add a unique design to one of your walls without picking up the paintbrush. Vinyl wall stickers give you the opportunity to add words, pictures, scenes or bold graphics to any clean, flat surface. These easy-to-apply bursts of creativity can turn walls, windows, furniture or the side of the fridge into a focal point for your room. Most importantly, they offer their vinyl lettering wall phrases and quotes at exceptionally affordable prices! So, great design is affordable and right at your fingertips!
As a fan of interior decorating on a budget, I love to find great deals that can really spice up a room. That’s why I was so excited to open my door to a package I received from my new friends at E.A.D Designs, who generously allowed us to select our very own wall quote for our humble abode…
So… we shot a video on our fun application to show you just how easy it is to apply and how great the results are!
And here it is…. so cute!
E.A.D Designs really has a wonderful assortment of options, colors and sizes and their site is so well labeled, that searching for the perfect design & wording is extremely easy. The only problem I had was picking a fave from so many great designs – it took me a really long time to pick a review item! Just look at some of their creative designs…
So, do you want to add a bit of personality to that blank wall of yours? Our winners this week will be scoring this exact wall quote from E.A.D Designs!
EAD Designs decals and designs make GREAT gifts for any holiday, weddings, baby showers, birthdays, housewarming or just because.
They also LOVE custom orders!
So here’s how you can enter for a shot at taking this week’s prize to the wall:
- Prize: A vinyl wall quote from E.A.D Designs (valued at $24)
- To Enter: Comment “Home is where my story begins” and tell us…
- Bonus Question: … Briefly… how that statement is true for you and where you plan to use the prize!
- Giveaway Closes: Thursday, April 14th at 8pm EST
- Number of Winners: Two lucky winners will score one of these fabulous quotes!
- Prize Ships: All over the U.S.
- Rules: One entry per e-mail address is permitted. For a Bonus Entry, become a fan of E.A.D. Designs on Facebook… Just click here! If you opt for the extra entry, please do that first & let us know on your comment. The winner will be selected using random.org and announced on Friday, April 16th. Good luck!
Are you a reader & want to know more about these things we call “Gracious Giveaways”? Click here. Or, are interested in hosting a giveaway right here on A Design Story? Click here. (We also offer excellent rates for Advertising… click here.)
Stay tuned for Wednesday’s Post for more fabulous information about E.A.D Designs… in the meantime, enter the contest & then visit E.A.D Designs Blog… click here! Or if you are ready to shop… click here!
Images are courtesy of E.A.D Designs & A Design Story, LLC. Video brought to you by us, A Design Story, LLC & Mark Weeks.

domain: design


text:
Opiate Pain Relievers for Cancer Pain
Why It Is Used
Opiate pain relievers are used to ease pain caused by surgery, accident or injury, or chronic illness such as cancer.
Methadone also is used to treat addiction to opiates, such as heroin.
Hydrocodone also is used to control coughing.
|By:||Reference Healthwise Staff||Last Revised: May 14, 2012|
|Medical Review:||Reference E. Gregory Thompson, MD - Internal Medicine
Reference Michael Seth Rabin, MD - Medical Oncology


Governor Simon Lalong of Plateau has said that he has great confidence in the Nigerian judiciary.
Lalong stated this on Wednesday in Jos when he interacted with some journalists after he attended the sitting of the election petition tribunal were the PDP candidate, Senator Jeremiah Useni, is challenging his reelection.
The governor said that he attended the tribunal’s proceedings because of the respect he has for the judges, the panel and the law profession.
He said that justice would be done to the cases and that anybody that was not satisfied had another opportunity to seek redress.
According to him, there are hierarchy of courts for people to take there cases to.
He said: “As a legal practitioner myself, I was in the court to learn, the legal profession keeps changing.
“I have obligation toward my people and the legal profession and I am a party to the case.
“Besides, after my tenure as governor, I will go back to the practice, so let me be abreast with what is happening before the tribunal.”
Lalong said that he would continue to attend the proceedings of the tribunal if time permitted.


Contact & Booking : https://www.facebook.com/acousmie/ or firstname.lastname@example.org
Acousmie is a swiss duo from Lausanne.
Friends from long date and music lovers, they've been enjoying music together since years berfore starting production after getting their fingers on a MPC.
Techno lovers but inspired by a lot of different styles. They've both started individually as hip-hop producers to finally go to their real goal and passion : Techno
They've started to play together when their two different styles have met in a mixer in 2014.
Live act specialists, music is their reason for living! Just freshly arrived on the music scene, they've been playing all over Switzerland and Europa in several festivals and venues like L'Usine, La Ruche, Le Weetamix, le MàD, le Baby Boa, the Shelter Club, le Ned, The Strobe Klub @ Montreux Jazz Festival(plus many more).
They have signed their first track on Intimist records in 2015 to finally achieve the dream of opening their own label "The Limbiic System Records" in 2016 with their friend Yann Detroit.
We like it RAVE style, we like it RAW!
The Limbiic System Records
Lethal Script Label
Physical Techno Recordings
The Red Skull
2018 Past & Upcoming Gigs:
18.02.2018 Stream Protocol @ Lausanne, CH
24.02.18 Bearl'in Station @ Le Cercle, Conthey, CH
02.03.18 4to8 @ secret spot, CH
16.03.18 Spektrum Pre-party @ Vinyl Club, Lausanne, CH
24.03.18 Tournée Générale @ Couleur 3, CH
31.03.18 Spektrum with Sleeparchive @ Halle W, Geneva, CH
06.04.18 Calm Before the Storm @ le Zoo/l'Usine, Geneva, CH
26.05.18 Necrose @ Le Cercle, Conthey, CH
20.07.18 Grosse Branlée @ Le Zoo/l'Usine, Geneva, CH
26.10.18 No Empty Floor @ Lausanne, CH
10.11.18 Erste Klasse Rave @ Neuchâtel CH
30.11.18 Globale Locale @ Le Zoo/L'Usine, Geneva, CH
2017 Gigs :
01.01.17 New Year's eve @ Starbeats Experience, Barcelona, SP
02.02.17 Environnement sonore @ Central Station, Geneva, CH
25.02.17 Carnaval de Fribourg @ El Diablo, CH
18.03.17 Warehouse Project @ MàD, Geneva, CH
25.03.17 PALP Festival on tour @ Caves du Manoir, Martigny, CH
30.03.17 Reloaded @ Mambo, Geneva, CH
08.04.17 Calm Before the Storm @ le Zoo, l'Usine, Geneva, CH
22.04.17 Secret Rave Party @ Geneva, CH
14.06.17 Bearlin Station @ ô box, Sierre, CH
07.07.17 OffGround night @ Strobe Klub, Montreux Jazz Festival, CH
26.07.17 The Booth @ Folklor, Lausanne, CH
08.08.17 Cirrus / Festival Electron Stage @ Fêtes de Genève, Geneva, CH
18.08.17 Fraxinus Excelsior @ Secret Place, Lausanne, CH
24.08.17 Les Jeudis Electro Festival @ Thonon, FR
29.09.17 BASMNT @ Baby Boa, Geneva, CH
07.10.17 Bi:Chromie @ Weetamix, Geneva, CH
13.10.17 Re-Born [Techno] @ Le Zoo, l'Usine, Geneva, CH
02.12.17 Bi:Chromie @ Void Club, Berlin, DE


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domain: chemistry


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Kitzhaber to attend Obama's State of the Union
Kitzhaber announced Tuesday morning that, thanks to an invite from the First Lady, he will be in attendance as President Barack Obama delivers his State of the Union address tonight beginning at 9 p.m. EST.
“The President understands the value of partnering with states to drive innovation, and it's gratifying for our efforts here in Oregon to be recognized," said Kitzhaber in a statement. "Working together with the Obama Administration, Oregon is scaling up innovative models that show how government can do more with less. These performance partnerships, which emphasize federal flexibility and local accountability, are key to achieving improved health care outcomes and efficiencies, creating better results for our students, and building the infrastructure we'll need to unleash the 21st century economy."
Oregon's coordinated care health care system, in particular, has garnered impressive federal support. The state landed $1.9 billion to support creation of coordinated care organizations to help unify treatment processes for patients.
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Inside Sales Daily Journal of Commerce | Portland, OR
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Chairman Wang Jianzhou said in an interview on Thursday that China Mobile has been in talks with Apple about producing a high-speed 4G iPhone, according to Bloomberg. The carrier has been working to launch its time-division long-term evolution, or TD-LTE, fourth-generation data network, and wants to see that Apple's iPhone is compatible.
"We discussed this issue with Apple," Wang reportedly said. "We hope Apple will produce a new iPhone with TD-LTE. We have already got a positive answer from Apple."
Currently, the iPhone is exclusive to China Unicom in the nation of over a billion people. But China Mobile is the largest prize, with more than 611 million subscribers.
The iPhone currently operates on 3G data speeds, but newer and faster 4G networks are spreading across the globe. Apple has publicly downplayed the prospect of embracing LTE technology in the iPhone in the near future, as first-generation LTE devices available on the market have been plagued with poor battery life, among other issues associated with the still-early technology.
In April, Apple Chief Operating Officer Tim Cook indicated his company is in no rush to adopt 4G technology in its products. He admitted that Apple has explored LTE, but the company wasn't ready to make the jump with the launch of a CDMA Verizon iPhone in February.
Before Apple creates a TD-LTE iPhone for China Mobile, it will likely first introduce a 3G-capable model compatible with its unique homegrown network. Wang revealed on Thursday that there are more than 8.5 million iPhone users on China Mobile, but those using unlocked phones are restricted to the carrier's much slower second-generation network. Apple is rumored to release the its fifth-generation iPhone for China Mobile this year.
In March, Wang went on record as saying that Apple Chief Executive Steve Jobs had "expressed interest in an LTE iPhone" and was willing to start development "at an early date." Wang also said in January that Apple has "made it clear" that future updates to the iPhone will support long-term evolution 4G technology.


Thanks, that was my impression of the boats. Glad to hear a contrarian view on the BMW; some of what I had read were negative. Not overly so, but complaints.
I looked at an S2 8.0A years ago with a BMW diesel. I ran away. Don't be fooled...the marinized BMW engines of 25 years ago ought not be deemed to have quality equivalence to a new 700 series BMW auto (in fact, most Germans I know, and I know a lot
, scoff at BMW quality anyway, relative to MB and Audi.)
No, repeat no, real support for these engines in the US right now. It might run like a champ for the next 20 years, who knows?...if it craps out, good luck with service, and a replacement might cost more than you paid for the boat. Parts might be hard to come by.
Ya pays yer money and ya takes yer chances.
My $0.02 worth. I'd run.
PS. Never heard that thing about the Sovereigns...interesting.


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I don't know if you're still interested in the Port Orange city data. I answered your question 2 years ago, but I just deleted my answer, since the links have changed. The ones I provided at that time are now dead. So here is a fantastic link to Port Orange statistics: http://www.zillow.com/local-info/FL-Port-Orange/r_33498/
Also, I live and work in Port Orange, and I'm a Daytona Beach native. I've sold real estate in every city in east Volusia County. If you're still interested, I'd love to help.
Lisa C. Hill. "The Smart Choice" for all your real estate needs
Adams Cameron & Co., REALTORSÂ®
The site below is to one page in my web site, strictly for Port Orange. If you click the "home" button, you can start from the beginning, and view the front page. You can also view my listings, and video tours of some of them. Our market is improving! So far, for every city I've checked this year, we have increased sales. You can view those charts on my blog at http://www.RealEstateBlogConnect.com. Here's the link directly to the Port Orange blog =)

domain: geography


WO/2016/080822 DEVICE FOR BUCKLE ASSEMBLY WITH A HOOK||WO||26.05.2016|
||PCT/MD2015/000007||PANCENCO, Vitalie ||PANCENCO, Vitalie |
The invention relates to mechanical engineering, namely to assembly units of the light industry. Summary of the invention consists in the use of a quick-change rotor, covering a wide range of sizes of hooks (25) and buckles (24), as well as the use of a universal rotating hook feeding hopper-drum placed on bearing rollers, and an assembly for hook orientation and feeding into the area of the rotor wheel. The device for buckle assembly with hook, according to the proposed invention, comprises a frame (1) with the installed thereon a drive motor (2) with gear unit (3), a hook feeding hopper- drum (7) with radial blades attached to its inner surface, a feed vibroplate (8) with vibratory motor, an incorrectly oriented hook discharge mechanism, a hook feeding mechanism with control cam (14), a mechanism for hook loading in the rotor wheel (20), and a rotor wheel connected to a drive shaft, a hook lug bending mechanism and a mechanism for removal of the assembled buckles with hooks from the rotor wheel (20). The technical result of the present invention is the simplification of the design of the device, providing a wide range of types and sizes of buckles and hooks corresponding to the needs for small-batch and single-piece production.
WO/2016/076693 POWER UNIT WITH DISCRETE ROTARY JET ENGINE||WO||19.05.2016|
||PCT/MD2015/000005||SCIGOREV, Iuri ЩИГОРЕВ, Юрий||SCIGOREV, Iuri ЩИГОРЕВ, Юрий|
The invention relates to mechanical engineering. A discrete-action rotary jet engine of a power unit has at least two combustion chambers. Combustion chamber covers are provided with automatic shutting devices which open the covers when the pressure in the combustion chambers is high; the covers are closed using return pushers. The combustion chambers are connected to a drive shaft via driving levers. An exhaust-gas propulsive force, which occurs when the covers are opened, rotates the drive shaft and an impeller, which impeller interacts with a guide casing to expel the exhaust gases and cool the engine. The impeller is equipped with a drive pulley for performing useful work. The invention allows for increasing efficiency.
WO/2016/056881 SAFETY SYSTEM FOR PREVENTING A LAND-BASED VEHICLE FROM SUBMERGING||WO||14.04.2016|
||PCT/MD2015/000004||VALCOV, Victor||VALCOV, Victor|
The invention relates to the field of transport engineering. A safety system for preventing a land-based vehicle from submerging comprises the following, arranged under the bottom of the vehicle: pneumatic cushions and a compressed gas cylinder which is connected to a gas distribution pipe via a regulator. The gas pipe is equipped with an electro-pneumatic valve to which an electric pneumatic pump is connected. Electro-pneumatic valves and nonreturn valves are mounted on gas-pipe connecting pieces connecting each pneumatic cushion to the gas pipe. Each cushion is equipped with a gas pressure sensor. The system comprises water sensors which are arranged under a cowl and in the vehicle passenger compartment. The water sensors are connected to the electro-pneumatic valve of the gas pipe. The gas pressure sensor in the gas pipe is electrically connected to the drive of the electric pneumatic pump. An increase in the reliability of operation of the system for preventing a vehicle from submerging is achieved.
WO/2015/133883 DEVICE FOR MANUALLY CONTROLLING AUTOMOBILE||WO||11.09.2015|
||PCT/MD2014/000002||ROZOVEL, Pavel РОЗОВЕЛ, Павел||ROZOVEL, Pavel РОЗОВЕЛ, Павел|
The invention relates to any type of vehicle devices which are intended for being controlled by people with limited physical capabilities. A device consists of a support, which is rigidly secured under the steering wheel of an automobile, on which are installed an assembly node and a bent operating lever; telescoping adjustment pulls are articulated to the lever, and the pulls are connected to the clutch and brake pedals and to the accelerator pedal by means of a sheathed metal cable. The invention is novel in that the assembly node of the bent operating lever allows for actuating the clutch pedals by means of pulling the bent operating lever vertically toward oneself and allows for actuating the brakes by means of pressing the bent operating lever horizontally away from oneself (in the direction of motion of the automobile), and in that all actions, including the actuation of the accelerator pedal, are carried out by a driver by means of manipulating the bent operating lever using only one hand.
WO/2015/069094 REINFORCING ASSEMBLY FOR HORIZONTAL REINFORCEMENT OF STONE MASONRY||WO||14.05.2015|
||PCT/MD2014/000003||BOGUSLAVSCHI, Nicolai БОГУСЛАВСКИЙ, Николай||BOGUSLAVSCHI, Nicolai БОГУСЛАВСКИЙ, Николай|
The invention relates to construction materials, in particular to a reinforcing assembly for the horizontal reinforcement of stone masonry consisting of such materials as, for example, brick, blocks of heavy or lightweight concrete, and also natural stone, and can be used in the construction of buildings for various uses, inter alia in seismic risk areas. The reinforcing assembly for the horizontal reinforcement of stone masonry in each stage is in the form of two separate mesh strips. Each of these strips comprises a straight rod and a bent rod of identical cross section, which rods are connected to one another and are situated in the same plane. A cell formed between the straight rod and the bent rod can be any shape, for example rectangular or segment-shaped. Meshes are arranged in pairs, with their straight rods towards the outside, in each stage of the masonry, wherein the distance between the straight rod and the corresponding edge of the wall is 20 - 40 mm. If the distance is less than 20 mm, in the event of seismic activity the reinforcing assembly may displace the mortar and the wall will be destroyed. If the distance is greater than 40 mm, the effectiveness of the reinforcing assembly will be reduced owing to the proximity of said reinforcing assembly to the non-working central zone.
WO/2014/196848 METHOD OF OPERATING A BOILER UNIT AND THE BOILER UNIT||WO||11.12.2014|
||PCT/MD2014/000001||PANFIL, Iurie ||PANFIL, Iurie |
The present invention relates to field of heat power engineering in particular to methods of conducting the process of fuel combustion and may be used in boiler units for burning different types of fuel. The proposed method of operation of the boiler unit by recovering heat from the flue gases by substituting of the excess part of the cold air, containing oxygen that is not participate in chemical reaction of fuel combustion with an equal part by mass of the cooled gases which allows to maintain in the flue gases content of oxygen less than 1% in the absence of carbon monoxide, by controlling supply of the cold air and the cooled gases to obtain a mixture of depending on the kind, properties, and / or the amount of combusted fuel in according to the load of the boiler unit.
WO/2013/112035 DEVICE AND PROCESS FOR WORKING OF CASTING MOLDS WITH POWDERED LUBRICANT||WO||01.08.2013|
||PCT/MD2013/000001||PANCENCO, Vitalie||PANCENCO, Vitalie|
The invention relates to foundry, particulary to devices and methods for working of casting molds. The device for working of casting molds with powder lubricant consists of a body (1) with a worktable (2) and a flap cover (3), under which, on a frame (11) by means of springs (12) are mounted brushes (6), (6'). In the body (1) is mounted a main electric motor (4), coupled with a brush (6), (6') driving mechanism (5) and a disk (8), (8') swinging mechanism (7), on which are placed the casting molds with the cavity open upwards; a suction fan (9) with a storage tank (10), placed in the body (1) under the worktable (2); installed on bearings (14), (15), a crank shaft (13), on which are fixed the brushes (6), (6'), and joined with the brush driving mechanism (5) by detachable half-couplings (16), (17); a vibromechanism for feeding the powder lubricant on the inner surface of the molds, containing an additional electric motor (18) with disbalance and a pull rod (19) joined with several tanks (20), (21) with powder lubricant, placed above the disks (8), (8'), as well as contains a device duty cycle control unit. In the method for working of casting molds with powder lubricant is carried out dusting of casting molds in a closed space with concomitant lapping with moving brushes of the inner mold surface with powder lubricant, at the same timer the casting molds are in rotation; is carried out the metered flow of the lubricant, is collected the excess lubricant, and the duty cycle, comprising dusting of casting molds with lubricant and its feed, is automated and controlled.
WO/2013/073927 PROTECTIVE SUBSTANCE AGAINST NON-IONIZING RADIATION, METHOD FOR ITS PRODUCTION AND PROTECTIVE DEVICE USING IT||WO||23.05.2013|
||PCT/MD2011/000003||IVANOV, Veniamin ||IVANOV, Veniamin |
The invention relates to substances protecting people from non-ionizing radiation of various types, in particular, of non-ionizing radiation resulting from the operation of industrial and household equipment, radioactive, geopathogenic and cosmic radiation, to methods for producing the protective substance, as well as protective devices using it. The protective substance against non-ionizing radiation, according to the invention, comprises water with a modified structure, ions of rare-earth elements such as cerium, in the amount of 0.0012...0.0080 mole/L and formic acid in an amount of (1...5) g/L. The method for producing a protective substance consists in the fact that in a capacity, made of dielectric material, is placed water and metallic silver in the mass ratio of 1000:1 and is treated with a magnetic field of an induction of (10...12) mT for three days, it is passed through an electromagnetic separator for 5 minutes and is carried out the electrolysis using on a metal cathode a powdery rare-earth metal such as cerium, in an amount of 0,002...0,005 g/L at a current density of 1,5 A/dm2 during (5...10) minutes, and after electrolysis is added formic acid in an amount of (1...5) g/L. The protective device is made in the form of a plate, including a substrate made of natural cellulose fibers, for example cotton fibers, on one side of which is applied a thin layer of a protective substance, and placed between two layers of moisture-proof material. The result is the almost complete damping of the negative radiation and creation of a user-friendly protective device.
WO/2012/165933 HYDRAULIC DRIVE WITH CLOSED WORKING FLUID CIRCULATION SYSTEM AND CORRESPONDING HYDRAULIC DISTRIBUTOR||WO||06.12.2012|
||PCT/MD2011/000002||YURKIN, Vladimir ||YURKIN, Vladimir |
The invention relates to engineering hydraulics, in particular to hydraulic drives with closed working fluid circulation system used, for example, in mechanical engineering, shipbuilding, machine-tool and aircraft building. The hydraulic drive with closed working fluid circulation system contains a hydraulic accumulator (1) connected through a pipeline with an unregulated single-rotating hydraulic pump (2) with a drive motor. The hydraulic pump (2) is connected through pressure (4) and drainage (5) pipelines to a hydraulic distributor (6) with a control lever (7), at the same time the hydraulic distributor (6) is connected through pressure-drainage pipelines (8, 9) to the chambers of a double- acting hydraulic motor (12) with a piston (13) and rods(14, 15). Between the pressure and drainage pipelines is connected a check valve (16). The hydraulic flow distributor, according to the invention, is made crane-type, three-position, six-way, consisting of a cylindrical body, in which is installed by means of seals and bearings a shaft, which is closed on one side with a cover, on the other side with a pressure washer, on the shaft is mounted a control lever. In the cylindrical body and the shaft are made in two levels: pressure and drainage, three holes ands three flow passages, correspondingly, in the same plane, which when switching the control lever create alternately pressure and drainage flow passages. The technical result of the invention consists in that the hydraulic drive has a wide range of manufacturing and operating capabilities, large capacity and speed, positional accuracy of the actuators, compactness, low weight and high reliability.
WO/2012/154017 METHOD FOR VERIFYING THE AUTHENTICITY OF SECURITIES AND DEVICE FOR ITS REALIZATION||WO||15.11.2012|
||PCT/MD2012/000003||VASILIEV, Serghei ||VASILIEV, Serghei |
The present invention relates to methods and devices for verifying the authenticity of various securities and may be used for determining the authenticity of banknotes, financial documents, identity cards and other important documents. The method consists in that the security is transilluminated with a light flux passing from a light source to a receiver, is registered the feature of paper, is compared the registration result with the reference feature, obtained during the control test and stored in a database of reference features, the coincidence of signs confirming the authenticity of the security. As a protective element is used an image in the form of a projection on the receiver of patterns, formed by its nearest 1-6 layers of fibers inside the texture of paper, of the preselected control site, the dimensions of which exceed the transverse dimensions of the paper fibers at least twice. It is carried out the identification of security with the ability to locate the control area defined by the coordinates and/or typographical feature, the security is transilluminated with a light flux on the control area, is registered the control area image with a resolution of at least 1200 pixels per inch. In the alternative embodiment of the device for realization of the method for verifying the authenticity of securities, which is a mobile phone, the light source and the receiver being aligned in different parts of the body, the receiver is made in the form of a flat photosensor having a resolution of at least 1200 pixels per inch. In another alternative ambodiment the light source is located by the circuit of the photosensor, at the same time the device is equipped with a means for security pressing to the photosensor, reflecting the luminous flux, emitted by the source, on the photosensor. At the same time in both alternative embodiments of the device the protective layer of the photosensor is made in the form of a light-guiding plate with photoconductive elements, which transmit the luminous flux to the surface of the photosensitive layer. The result, achieved at the realization of the present invention, consists in providing the simplicity, high reliability and validity of authentification of securities.


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Inherited Parcels Trump Law
Question: After our father passed away recently we learned that he had created a revocable living trust with myself and my six brothers and sisters as equal beneficiaries. One of the assets in this RLT is an 80-acre agricultural parcel of land near Buckeye. My understanding is that, if a parcel of land is split into six or more parcels, the Arizona Department of Real Estate will require compliance with the subdivision laws, including a public report. Can this 80-acre agricultural parcel be divided equally into parcels of approximately 11.4 acres each among the seven children without a public report?
Answer: Yes. You are correct that, if a parcel of land is split into six or more parcels, there generally must be compliance with Arizona subdivision laws, including the filing of a public report. This public report can be expensive and must disclose to potential owners such facts as access to utilities, ingress and egress to the property and water rights. An exception to this requirement of a public report, however, is any split into six or more parcels by “operation of law.” An example of this exception is the dissolution of a corporation with more than six shareholders that owns a parcel of land. Another example is a transfer upon death, e.g., your father passing away with his seven children as beneficiaries of his revocable living trust. Therefore, each of your father’s seven children should be able to receive a parcel of approximately 11.4 acres without any public report. Finally, each of the seven children could then split the parcel that they receive into up to five parcels to be offered for sale to buyers without a public report.

domain: law


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It’s on! The Cleveland Cavaliers are taking on the LA Clippers at Staples Center and both teams are hungry for a win. We’ve got your way to catch the big game Mar. 18 via live stream.
It’s go time for both the Cleveland Cavaliers and Los Angeles Clippers, as each team has been faltering with losses as the playoffs loom just a month away. The Cavs are still atop the Eastern Conference, but not by much and their 45 wins would put them in fourth place if they were playing in the much more competitive Western Conference. The once red-hot Clippers are sputtering as well, dropping their last three games. Still, these are two NBA powerhouses and they’re getting the big Saturday night prime time treatment Mar. 18, so scroll down for live stream details.
The only other time these teams have met up this season was back on Dec. 1. 2016, where the Clippers stomped the Cavs on their home turf 133-94. Now they’re squaring off in LA at Staples Center and the Cavs are starting off a four game road trip, as they’ll stick around LA to play the Lakers Mar. 19 then head on to Denver and Charlotte before returning home again.
Cleveland is having one of the worst months of any team in the league, going 4-9 in March. The good news for the Cavs is that Kevin Love finally returned to the lineup Mar. 16 in a win against the Jazz after suffering undergoing knee injury Feb. 14. The team has gone 8-6 in their last 14 games without the four-time All-Star starting for the team. He practiced in 3 and 3’s earlier in the week and told the Cleveland media Mar. 15 that, “I’m 28 years old, I feel like I’m just coming into the league again because I’m so antsy to get back. It’s good,” he said. “You’ve got to trust the process, respect the process and give that leg time to heal, give injuries time to heal. But it’s not for lack of wanting to be out there.” We’re sure his teammates are glad to have him back in the mix!
HollywoodLifers, who are you rooting for in this game? Tell us in the comments.


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What will you write in your Thanksgiving card
The Thanksgiving holiday season is a time to give thanks. And, sharing your thoughts with friends, family, and loved ones is the perfect way to let them know the many reasons why you`re grateful.
Forget ghosts and goblins—plenty of eerie creatures live under the sea. Answer these questions about some of the ocean’s weirdest oddities in this oceanic quiz game.
What does your necklace style says about you
What Mardi Gras‘s Color Matches Your Personality
Which Downton Abbey Character Are You
What Will Your Relationship Status Be On Valentine's Day？
Which Bible Character Are You
What Will Santa Put In Your Stocking This Year
Which Disney Movie Defines Your Childhood
What's Your Cool Girl Quote
What Outfit Should You Wear On New Year's Eve
What does Dark Phoenix want to say to you
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Disclaimer:All content is provided for fun purposes only


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How to clean sofa? One Hygienic provides professional sofa cleaning and sanitising service to residential and commercial properties in Malaysia. We can clean and protect your upholstery, cushion, fabric, leather and suede couch.
The highlight of One Hygienic’s cleaning system is the ability to refresh brightness and details of upholstery, that have been aged due to accumulation of dust, dirt and stains. Our revolutionary cleaning system have surpassed many conventional sofa cleaning systems.
Advantages of Upholstery Hygiene Treatment
- Cleaning can be done at home, office & business premises
- Almost no drying time. Note: Heavily stained fabric would require slight drying time
Service Quality Assurance
- Refresh brightness of fabric colour
- No shrinkage of fabric
- Removal of different types of spots & stains. Note: Result depends on the nature of stains
No Chemical Residue
- No chemical residue on fabric
- Safe for the baby, adolescence & elderly
Not Only Cleaned, Also Sanitised!
- Eliminate bacteria, fungi and other micro-organisms
- Delay re-infestation of dust mites
A special high-speed rotating brush will infuse shampoo foam onto the upholstery for effective cleaning.
The foam traps the dirt through crystallizing process.
3. Brush off
Once the foam crystallized and dried, the crystal-form residues are brushed off and removed easily.
Finally, the application of the internationally patented Potema® Sanitising Spray would protect the upholstery set against bacteria and viruses and delay the re-infestation of dust mites and allergens.


News hotlines: 08111813019, 08025868561
Email: firstname.lastname@example.org, email@example.com
Investigations by Business Hilights Intelligence Unit (BHIU) have shown that illegal logging for endangered species are ongoing in forest parts of Ogun Edo and Ondo states in Nigeria for export to China in containers.
Also in Ghana, since the uncontrolled logging of rosewood for export mostly to China began in the Upper West Region of Ghana some three years ago, the impact is being felt in the mostly farming communities. Communities have started reporting erratic rainfall patterns, storms, poor harvests and bushfires.
In Ghana, timber resource allocation and harvesting are regulated by the Timber Resources Management Act, Act 547 of 1998 and the related Regulation LI 1649 of 1999.
For Rosewood, however, the issuance of permit to contractors prior to exploitation and monitoring exploitation once the permit has been issued has been the main regulatory mechanism since the surge in its export, the Forestry Commission says.
Checks in parts of Ore, Sagamu and Ijebu-Ode axis in the South West show that illegal logging and containerization are now on a daily basis on suspicious collaboration with locals and even relevant law enforcement officials.
Some of the operators who spoke to our undercover reporter revealed that the woods are containerized and illegally smuggled to China and other South-East Asia where they are used for wood works.
In an interview with Ogun Customs Command and a top official at Federal Operations Unit (FOU), Ikeja, they confirmed steady seizure of containerized woods billed for exports and assured that they will continue to track the perpetrators until zero logging is attained.
Giving a chilling analysis of the scenario in Ghana, Michael Asante a small-scale timber harvester operating in the Upper West Region of Ghana, said “Here we don’t have the rules that govern concessions, where one can only harvest wood from allocated concessions like in other parts of Ghana where timber is harvested. In this area, people harvest whatever, and wherever they can find rosewood.”
He averred that “Here, while the local people don’t know the value of the rosewood, no company operating in the area has permit to cut down trees; they only have permits to collect.”
Business Hilights Ghana Bureau chief recalls that even though there is currently a ban on felling rosewood trees in the region, there is evidence the law is being violated – fresh trees are being cut, and not many offenders are facing the law.
However, Asante who says he has been in the timber business for more than 10 years, believes that at the current rate of harvesting, rosewood will be gone from the region in three years, and he has a plan ‘B’.
It was discovered that whereas there are no official figures, the number of Chinese citizens in Ghana’s Upper West Region at any point in time is estimated around 150. Local people say they are financing and supplying chainsaw machines and other wood processing equipment for local tree hunters.
Currently, China’s lust for rosewood is growing in West African rainforest region and the illegal exploitation had been captured at a Briefing for the 66th meeting of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) standing committee in January 2016.
The report revealed through a year-by-year comparison of Chinese import data indicates that West Africa has experienced a wave of boom-and bust Hongmu (rare and valuable “red wood” used primarily for antique-style furniture in China) trade cycles. The first country affected by increased rosewood exploitation was Gambia (2011-12), followed by Benin (2012-13) and Côte d’Ivoire (2013-14), Ghana (2013-14) and Nigeria (2014-15).
Also, Hongmu exports from West Africa have grown more than 1,000 fold between 2010 and 2015. West Africa is now the world’s leading hongmu-producing region by volume. The main species is Pterocarpus erinaceus, known as “Kosso,” found in the dry forests of West Africa, where the unsustainable harvest increases the risk of desertification. In Senegal’s Casamance region, the rosewood trade has fueled rebel activities through the smuggling of Kosso to neighboring Gambia.
Business Hilights is an online news channel conceptualized and structured to report and track on a daily basis; latest developments in critical business sectors to serve as a one stop news gateway for governments, foreign and indigenous investors.


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Exosomes, the smallest sized extracellular vesicles (∽30-150 nm) packaged with lipids, proteins, functional messenger RNAs and microRNAs, and double-stranded DNA from their cells of origin, have emerged as key players in intercellular communication. Their presence in bodily fluids, where they protect their cargo from degradation, makes them attractive candidates for clinical application as innovative diagnostic and therapeutic tools. But routine isolation and analysis of high purity exosomes in clinical settings is challenging, with conventional methods facing a number of drawbacks including low yield and/or purity, long processing times, high cost, and difficulties in standardization. Researchers from Texas A&M University discuss a promising solution, microfluidic-based technologies that have incorporated a host of separation and sensing capabilities for exosome isolation, detection, and analysis, with emphasis on point-of-care and clinical applications. These new capabilities promise to advance fundamental research while paving the way toward routine exosome-based liquid biopsy for personalized medicine.
Microfluidics for exosome isolation and analysis – enabling liquid biopsy for personalized medicine
Contreras-Naranjo JC, Wu HJ, Ugaz VM. (2017) Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine. Lab Chip [Epub ahead of print]. [abstract]


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We already proposed and shall scream more about the solution, eliminate T fare. Otherwise, the only debate available is how can we make the T profitable. It's the wrong discussion.
Sort of apology: This is off topic. The only marriage here would be of reason and government -- always an uncomfortable and unlikely couple. As a state and nation, we continue to pay many billions annually to subsidize the commutes, goods transfer and other highway costs of car and truck drivers. Let's be fair about fares.
No Surprises YesterdayThe first public hearing produced exactly what we should expect. Commuters and others say that raising the fare will repel riders when the T needs more.
Read accounts in the Metro, in the Herald, and in the Globe. They are very similar.
Ex-Governor Mike Dukakis -- a big mass-transit supporter and regular Green Line rider -- seemed the most sensible. He started by pointing out that $3 gas is a great motivator for riders, and as a result, this is exactly the wrong time to raise fares or reduce services.
He suggested that the commonwealth needs to stop pretending that the T is just some business. He wants legislators to reduce the MBTA's $5 billion-plus debt.
We suggest that the debt helps illustrate one aspect of the problem. If we treat mass transit as a public good, like highways, we gain the perspective. It should not scratch for a share of public money. Its funds should got to providing more and better transit, not to weaseling around the inane forward funding that the General Court imposed seven years ago, prohibiting even asking for fuel-increase adjustments. Dumb and punitive.
Meanwhile, T Deputy General Manager Dennis DiZoglio predicts a 6% drop in riders if the fare goes up. He also is looking at reducing bus and subway frequency to cut costs.
Again, this illustrates that the present funding and business model does not work and cannot work. Don't pretend that we can make money on the T; reap the benefits from a free mass-transit, and then expand it.
There are more hearings over the next month. Check the schedule, attend one, be vocal, free the T.
Tags: massmarrier, Massachusetts, Boston, MBTA, fare hike

domain: finance


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Music Gear News
The Script 'more accomplished' for fresh LP
Speaking with the Gigwise website, the singer also suggested that the stories told by album #3's tunes – as well as the themes that are worked into them - will be familiar to those who have heard the band's earlier work.
"I guess they're a little closer to home," he added. "On the last few albums there was one or two songs where we had a kind of out-of-body experience when we were writing, but with this album it was very much personal as there was lots going on in all our personal lives to draw on."
The Script are planning some American gigs in the likes of St Louis, LA, New York and Houston next month.
They have enjoyed success with songs such as The Man Who Can't Be Moved and current Single Hall of Fame, while O'Donoghue himself has appeared as a coach on the BBC talent programme The Voice.
#3 contains numbers such as Broken Arrow, Moon Boots and No Words.
Published by AW.Posted on 17 Sep 2012 16:20 to category : Band / Celebrity News
Related Music News
Former Skid Row frontman Sebastian Bach Spills the Beans On His Less Than Complimentary Thoughts Towards Today's Rock Musicians and Their Work Ethic In the Studio
The prestigious Rock and Roll Hall of Fame induction will be honouring several artists this year, including prog legends Yes. Rick Wakeman has stated that he will not be attending.
Laying the foundations for generations of artists to follow, the legendary musician Leonard Cohen has passed away from unspecified causes.
Stating it as more of a necessity for the band, M. Shadows highlights the importance of not stagnating and keeping things exciting
Cancelling his remaining shows in December due to ill health, fears arise over the guitar legends health
Verified by the guitarist himself, Slash's B.C Rich played a pivotal role in Guns N' Roses rise to fame
Recent Music News
With various different entries, Ibanez unleash a spectacular array of signature models to their NAMM 2017 line up
With extensive research conducted into how to make a kit that truly caters to the player and their specific needs, Pearl hit a home run with these one of a kind custom kits
A revamp of one of Ludwig's most popular snares, the Ludwig Black Beauty 14x8 projects classic tone and looks as good as the original
Mackie's Big Knob Studio Interface continues the legacy of its predecessors, championing various new features and exciting tech to reiterate its triumphant return.
Line 6's first ever artist designed guitar, the Shuriken personifies the aggressive and technical playing styles of metal enthusiasts around the world.
Building on the foundations of its predecessor the Prophet 08, the REV2 features a whole array of interesting and innovative additions to its format.


Sarajevo Canton Prosecutor's Office has launched an investigation into the death of a woman who posthumously tested positive for the novel coronavirus, according to the prosecutor's spokesperson.
The women died on Tuesday, and the coronavirus infection was confirmed after her death, which sparked comments and reactions about her treatment in healthcare institutions.
Spokesperson Azra Bavcic said the authorities will review the circumstances of the death and that no more details could be unveiled at this point of the investigation.
According to Mehmed Kulic, the Head of the Sarajevo Canton Healthcare Centre, it was not possible to determine a link between the patient's health issues and coronavirus, and that she was treated as a patient with respiratory problems.
Also, he stressed, the health workers were not familiarised with the patient's possible contact with someone coming from the countries severely affected by the virus.
“Such cases can happen in our communities and that we learn exceptionally important information afterwards,” said Kulic.


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Hepcidin, a 25 amino acid polypeptide hormone, synthesized in the liver, regulates iron balance by systemic iron metabolism in the body. It is synthesized by hepatocytes and decreases iron absorption in the duodenum and release of iron from macrophages, through binding to ferroportin consequently controlling the plasmatic concentration of the iron and its storage. Therefore, testing for hepcidin can be used as an indicator of bioavailability of iron. Hepcidin can be detected either by mass spectrometry or by immunological methods. Detection by mass spectrometry is technically challenging and provides information about different isoforms of hepcidin. The immunological methods are more common and currently in practice for detection although hepcidin is not usually done as a routine diagnostic parameter. Frequently used parameters to detect the iron status are serum ferritin, iron, transferring, total iron-binding capacity (TIBC), transferrin saturation (iron/TIBC), and C-reactive protein levels, but each one of these has constraint, hence to initiate this marker as a routine diagnostic parameter establishment of normal reference range is essential.
Globally, reference range values for hepcidin have been established in different communities; Pasricha et al. reported it as a diagnostic test in healthy premenopausal women in Australia with reference range values of 5.4 ng/mL–174.6 ng/mL; similarly, Galesloot et al. also established normal reference ranges for hepcidin according to gender and age in echelon of 5 years each in the general population of The Netherlands.
Sdogou et al. have reported it from Greece pediatric populace and established serum hepcidin reference range measurements in healthy children and evaluated differences among age groups with the help of immunoassay-based technique. The more recent hepcidin reference range was reported by Gonzo et al. in the year 2017 in Namibian blood donor populace. The values established in their study were 17.186–91.237 ng/mL for females and 18.227–81.541 for males. Emphasis on criteria for the selection of blood donors and management of donation-induced iron depletion is a major concern for clinicians. As blood donors are found to be at high risk of iron deficiency, hence, this populace is apt to assess novel tests of iron deficiency, and for prognosis and accurate diagnosis of any disease, appropriate reference range values are essential.
The present study was carried out to establish normal reference range values of serum hepcidin in Indian blood donors which might be supportive to figure out the baseline and reference point of hepcidin and to compare them with previously established reference values elsewhere which will help to explore its quantitative characteristics.
Materials and Methods
The study was conducted at the Department of Transfusion Medicine, in a tertiary care hospital, North India. The study was approved by the Institutional Ethics Committee. Ninety normal healthy voluntary blood donors of either sex, given consent to participate in the study, were recruited to establish reference ranges. Healthy individuals were defined according to the donation criteria as set out by the Ministry of Health and Family Welfare, Government of India, in the year 2017. The major criteria for donation include.
- First-time blood donors (because serum hepcidin is inversely proportional to number of blood donations)
- Donor shall be in good health, mentally and physically fit
- Donor should be between the age of 18 and 65 years
- Weight of the donor should be ≥45 kg with hemoglobin (Hb) ≥12.5 g/dL
- Donation interval should be more than 90 days for males and 120 days for females
- Donor shall be free from any disease which can be transmitted by blood transfusion
- Physiological status of women for blood donation should be:
- Defer for 12 months after delivery and 6 months after abortion
- Defer for total period of lactation and period of menstruation.
We have examined the participant's health and medical history by using standard donor questionnaire, comparable to Gonzo et al. They have also used a questionnaire to carry out the physical evaluations of their study participants to assist in determining their health status and lifestyle. Earlier, Galesloot et al. in their study in a large, well-phenotyped sample of the general population to determine the reference range of hepcidin have asked all the participants to fill a questionnaire to establish their health status, lifestyle, and medical history.
The standard donor questionnaire consists of different physical examination measures that include examining imperative signs such as blood pressure, weight, body mass index (BMI) as well as query about general health status of the donor including history of anemia and chronic illness. The purpose of donor questionnaire is to assess participants’ general health and medical history on the day of collection of blood to allow them to donate. They should meet certain criteria as mentioned by the Ministry of Health and Family Welfare, Government of India, in the year 2017 to qualify to donate blood.
Sample size calculation
Sample size at 90% power for females
Sample size is calculated on the basis of variation in hepcidin level among the study cases using the formula:
where σ = 17.19, the standard deviation (SD) of the hepcidin level in females among the study cases:
- d = 15% of mean hepcidin level, the difference considered to be statistically significant
- Type I error α =5% corresponding to 95% confidence level
- Type II error β =10% for detecting results with 90% power of the study.
Hence, the required sample size was calculated to be:
n = 62.
Sample size at 80% power for males
Because of less availability of first-time male donors, sample size was calculated at 80% power on the basis of variation in hepcidin level among the study cases using the formula:
where σ = 16.49, the SD of the hepcidin level in males among the study cases
- d = 20% of mean hepcidin level, the difference considered to be statistically significant
- Type I error α = 5% corresponding to 95% confidence level
- Type II error β = 20% for detecting results with 80% power of the study.
Hence, the required sample size was calculated to be:
n = 28.
After filling the questionnaire and obtaining the participants’ weight and vital signs such as blood pressure, blood samples (venous) were collected from healthy blood donors after obtaining consent. Samples collected were used to execute Hb, serum ferritin, and hepcidin assays. The samples for these assays were collected simultaneously along with blood donation in order to evade deviation in the concentration of hepcidin. After the blood donation, hepcidin concentration might get affected due to decrease in blood volumes which causes subsequent decline in iron content.
Hepcidin is reported to be the major iron-regulatory hormone which undergoes diurnal variation; considering this, all blood samples were collected between 08.00 a.m. and 9.00 a.m.
Serum hepcidin-25 was diagnosed according to the manufacturer's instructions by using a commercially available competitive enzyme-linked immunosorbent assay (ELISA) kit (Hepcidin-25 (bioactive) HS ELISA; DRG Instruments GmbH, Marburg, Germany). This ELISA kit is a solid-phase ELISA, based on the principle of competitive binding with a dynamic range of 0.135–81 ng/mL, mean intra-assay precision: 5.5%, mean inter-assay precision: 12.5%, and analytical sensitivity: 0.135 ng/mL.
ELISA plates containing 96 μl wells were precoated with a monoclonal (mouse) antibody directed toward the antigenic site of the bioactive hepcidin-25 molecule. Endogenous hepcidin-25 of a subject sample contends with the added hepcidin-25 biotin conjugate (enzyme conjugate) for binding to the precoated antibody. After incubation, the unbounded conjugate is washed off. Binding of the enzyme conjugate is detected by the streptavidin peroxidase enzyme complex. Color is developed by the addition of substrate solution and is stopped up after a short incubation. The intensity of color developed is inversely proportional to the concentration of hepcidin-25 present in the serum sample.
The other two hematological parameters, Hb and ferritin, were evaluated by Medonic M20 (Boule Medical AB, Sweden) and COBAS e 411 (Roche Diagnostics GmbH, Germany), respectively. Donors having Hb concentration <12.5 g/dL and ferritin level <12 ng/ml were excluded from the study.
The results were analyzed by descriptive statistics. Categorical data were summarized in proportions and percentages (%) while discrete as mean and SD.
The different statistics methods employed in the present analysis were:
The arithmetic mean
The most widely used measure of central tendency is arithmetic mean, usually referred to simply as the mean, calculated as:
The standard deviation (σ)
It is calculated by using the formula:
Prediction and confidence interval
Prediction intervals predict the value of an individual which lies inside the group. The key element is that the prediction interval describes about the distribution of values, not the unpredictability in establishing the population mean.
The 95% prediction range of biochemical parameter is calculated by using the formula:
The 95% confidence range of biochemical parameter is calculated by using the formula:
where x (bar) is the sample mean, s is the sample SD, and n is the sample size.
The P value was taken significant when < 0.05 (P < 0.05) and confidence interval of 95% was taken.
A total of 90 donors were recruited for the study after the stratification according to their eligibility to donate blood. It consists of 28 males and 62 females. The mean age of study subjects was 31.87 ± 9.01 years. The mean age of males was 29.86 ± 7.12 years while the mean age of females was 32.77 ± 9.66 years. Table 1 depicts the donor profile and their iron parameters. The mean ± SD of Hb level in male donors was 14.62 ± 1.34 g/dL and female donors was 13.33 ± 0.76 g/dL. The mean ± SD of ferritin level in total population was 78.37 ± 51.72 ng/mL; in male donors, it was 113 ± 56.12 ng/mL; and in female donors, it was 62.65 ± 40.8 ng/mL. Similarly, the mean ± SD of hepcidin level in total population was 14.44 ± 9.9 ng/mL; in male donors, it was 22.18 ± 12.17 ng/mL; and in female donors, it was 10.95 ± 6.06 ng/mL.
Data were analyzed and reference range was estimated using prediction interval method. Table 2 shows the descriptive summary and reference range estimation of hepcidin level among males and females; the mean hepcidin level of study subjects was 22.18 ± 12.39 ng/mL. This provides the 95% confidence range for mean hepcidin level as lower bound 17.59 ng/mL and upper bound 26.77 ng/mL, and the 95% prediction range which can be taken as reference range is estimated to be lower bound 0.00 and upper bound 46.89 ng/mL. Hepcidin distribution was with skewness index of 1.10 and kurtosis index of 0.82 which might be due to the comparatively small number of study participants. While, among females, the mean hepcidin level of study subjects was 10.94 ± 6.11 ng/mL. This provides the 95% confidence range for mean hepcidin level as lower bound 8.68 ng/mL and upper bound 13.21 ng/mL, and the 95% prediction range which can be taken as reference range is estimated to be lower bound 0.00 and upper bound 23.02 ng/mL. Hepcidin distribution was with skewness index of 1.10 and kurtosis index of 0.82 which again might be due to the comparatively small number of study participants.
Reference range of hepcidin level was also estimated using percentile method [Table 3]. Among males, the 5th and 95th percentiles of hepcidin level were found to be 6.32 units and 46.06 units, respectively, which provides the 90% percentile range for hepcidin level as 6.32–46.06 and can be taken as a reference range. While, among females, the 5th and 95th percentiles of hepcidin level were found to be 3.44 units and 24.78 units, respectively, which provides the 90% percentile range for hepcidin level as of 3.44–24.78 and can be taken as a reference range.
Table 4 shows the comparison between prediction interval and percentile method. The PI method provides larger range as a reference range as compared to percentile method and so includes more normal cases than the percentile method. Total 28 male, 27 (96.4%) were within the range and among female out of total 62, 58 (96.7%) were within the range. Whereas in percentile method only 92.9 % male and 93.3 % female were within the range.
In this study, reference ranges of serum hepcidin concentration were established for the healthy, nonanemic Indian blood donor. We demonstrated sex-specific reference ranges of serum hepcidin, and for its calculation, the participants having characteristics which manifestly manipulates the concentration of hepcidin, namely anemia and low ferritin concentration, were excluded; as a result, unambiguously affirmed precise serum hepcidin reference ranges were established, and these findings are consistent with those reported earlier. Study participants have not reported any restriction in their dietary behavior and BMI of all the subjects whether males or females were within normal values. The serum hepcidin reference ranges in our study are in accordance with hepcidin concentrations in healthy controls previously reported. The variance in absolute hepcidin level evident globally is due to the different assay methods; a comparative study on different assay methods for hepcidin concentration established that although there is a significant difference in the absolute value for results at all laboratories, when compared, the results for samples are showing good correlation and low analytical variation which obviously exemplify the necessity for coordination. Ganz et al. found a significant difference in serum hepcidin level between men and women; in our study, we also observed a considerable difference among both sexes.
In our study, we found a correlation between hepcidin and ferritin levels; in males, the mean hepcidin level was higher as compared to females so as with ferritin level also; the mean level of ferritin was higher in males as compared to females, indicating an association between serum ferritin and serum hepcidin levels, and these findings are consistently been reported previously. In a very recent study on blood donors from India, researchers have reported that serum hepcidin levels are moderately correlated with serum ferritin levels and stated the effectiveness of hepcidin as a diagnostic marker for iron deficiency. They suggested that large multicenter studies are required to attain the final conclusion.
Our study provides sex-specific reference ranges of serum hepcidin concentration in Indian blood donors. In iron-deficient conditions like anemia, usefulness of these ranges is helpful as baseline information for the exposition of the properties of hepcidin-25. In the present study, the established reference range values were 6.32–46.06 ng/mL for males and 3.44–24.78 for females. Development of this index of hepcidin reference range would be helpful in interpretation of clinical samples and facilitate interlaboratory collaborations. The use of an authentic commercial kit assures the consistent outcome. These findings propose further studies with larger groups of donors would be required to produce reference values of hepcidin that can be specified to the entire populace in India.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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Santa. #creepy, cause Creepy Santa Claus, creeping on me... knowing all that stuff. He doesn't know jack! He still gives me presents but then again I'm a good guy. At least I want to think I am good. I'm one of Santa's little helpers that puts in tons of overtime.
- 100% pre-shrunk cotton (heather gray color is 90% cotton/10% polyester, light heather gray is 98% cotton/2% polyester, heather black is 50% cotton/50% polyester) | Fabric Weight: 5.0 oz (mid-weight)
- Double-stitched seams at shoulder, sleeve, collar and waist
- Special Note: Mineral Wash colors have a slight yellow tint and not one is the same due to the special dye process
- Imported; processed and printed in the U.S.A.


The January 1st, 2005 START Treaty exchange data released in April 2005 show the changes in the composition of the Russian strategic forces. As a result of these changes Russia currently has a total 830 strategic delivery platforms, which can carry up to 3494 nuclear warheads.
The total number of intercontinental ballistic missiles now stands at 560. These missiles can carry 1970 warheads. With the closure of the base in Kartaly, which is almost completed by now, the number of the heavy SS-18 (R-36MUTTH/R-36M2) missiles has reached 85. This number will be reduced even further – to 40 R-36M2 missiles – after the Strategic Rocket Forces complete decommissioning of older R-36MUTTH missiles.
The number of deployed SS-25 (Topol) road-mobile missiles has reached 306, continuing the process of gradual decommissioning of this missiles at a rate of about 15 a year, which began in 2002. This trend is expected to continue.
The Kostroma missile division, which included 15 SS-24 (RT-23UTTH) rail-mobile missiles, is at the last stages of liquidation, so we no longer count these missiles as operational. Russia no longer has missiles of this type in its force.
A summary of the current status of the Russian strategic forces can be found here.