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- CHMP opinion based on Phase III REACH2 and REACH3 trials that showed Jakavi improved response rates and failure-free survival compared to best available therapy1,2
- Graft-versus-host disease (GvHD) is a serious and debilitating complication of stem cell transplants, with no established standard of care for patients who do not adequately respond to first-line steroid treatment3,4
- Nearly half of patients experience either acute or chronic GvHD, or both, following allogeneic transplants3,4
Basel, March 25, 2022 — Novartis announced today the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion recommending approval of Jakavi® (ruxolitinib) for the treatment of patients aged 12 years and older with acute graft versus host disease or chronic graft versus host disease (GvHD) who have inadequate response to corticosteroids or other systemic therapies. If approved, Jakavi will be the first JAK1/2 inhibitor available for patients with GvHD in Europe4.
“For many hematologic diseases, allogeneic transplant is the only treatment with the potential to be curative; however, half will go on to develop acute or chronic GvHD,” said Dr. Robert Zeiser, University Hospital Freiburg, Department of Haematology, Oncology and Stem Cell Transplantation, Freiburg, Germany. “It is encouraging that we may soon have a new standard of care for patients with this often debilitating condition who do not adequately respond to first-line corticosteroids or other systemic therapies.”
The CHMP positive opinion was based on data from the Phase III REACH2 and REACH3 clinical studies, in which Jakavi demonstrated superiority versus best available therapy (BAT) in patients with steroid-refractory and steroid-dependent acute and chronic GvHD, respectively.
Results from the REACH2 trial showed that overall response rate (ORR) at Day 28 was superior in the Jakavi arm at 62.3% vs. 39.4% in the BAT arm (odds ratio [OR], 2.64; p<0.001) in patients with steroid refractory/dependent acute GvHD. In those patients who maintained response at Day 56, the ORR in the Jakavi arm was 40% vs. 22% in the BAT arm (p<0.001). In REACH3, treatment with Jakavi led to significant improvements in ORR compared to BAT (49.7% vs. 25.6%; OR, 2.99; P<0.0001) in patients with steroid-refractory/dependent chronic GvHD at week 24, the primary endpoint of the study, regardless of the individual organs involved at baseline. Also, best overall response (BOR) rate at any time up to week 24 was achieved in 76.4% of patients in the Jakavi arm compared to 60.4% in the BAT arm (OR, 2.17; 95% CI, 1.34-3.52). Results from the two studies were published in the April 22, 2020 (REACH2), and July 15, 2021 (REACH3) issues of The New England Journal of Medicine1,2.
GvHD, a common and potentially life-threatening complication that can arise after allogeneic stem cell transplants, is a reaction where the donor’s cells see the recipient’s normal cells as foreign and attack them. Symptoms of GvHD can appear in the skin, gastrointestinal tract, liver, mouth, eyes, genitals, lungs, and joints3,5-8.
Approximately 50 percent of allogeneic stem cell transplant recipients experience either acute or chronic GvHD, or both4. Acute GvHD typically occurs within the first 100 days of transplant, while chronic GvHD generally occurs more than 100 days after transplant. Both acute and chronic GvHD can be fatal and until now both have lacked an established standard of care for patients who do not adequately respond to first-line steroid treatment3,4.
“This positive CHMP opinion for Jakavi in GvHD brings us one step closer to approval in Europe, for a condition where patients often experience severe and life-threatening symptoms,” said Susanne Schaffert, PhD, President, Novartis Oncology. “With this exciting news, we may change the way GvHD is treated as about half of patients do not respond to previous corticosteroids or other systemic treatment.”
The CHMP’s positive opinion of Jakavi in acute and chronic GvHD will be referred to the European Commission (EC), which has the authority to grant marketing authorizations for medications in the EU. The EC will review the CHMP recommendations and is expected to make a final decision within approximately 2 months.
About Jakavi® (ruxolitinib)
Jakavi® (ruxolitinib) is an oral inhibitor of the JAK 1 and JAK 2 tyrosine kinases. Jakavi is approved by the European Commission for the treatment of adult patients with polycythemia vera (PV) who are resistant to or intolerant of hydroxyurea and for the treatment of disease- related splenomegaly or symptoms in adult patients with primary myelofibrosis (MF) (also known as chronic idiopathic MF), post-polycythemia vera MF or post-essential thrombocythemia MF. Jakavi is approved in over 100 countries for patients with MF, including EU countries, Switzerland, Canada, Japan and in more than 85 countries for patients with PV, including EU countries, Switzerland, Japan and Canada. The exact indication for Jakavi varies by country. Additional worldwide regulatory filings are underway in MF and PV.
Novartis licensed ruxolitinib from Incyte for development and commercialization outside the United States. Ruxolitinib is marketed in the United States by Incyte as Jakafi® for adults with PV who have had an inadequate response to or are intolerant of hydroxyurea, for adults with intermediate or high-risk MF, for adult and pediatric patients 12 years and older with steroid-refractory acute GvHD, and adult and pediatric patients 12 years and older with chronic GvHD after failure of one or two lines of corticosteroids or other systemic therapy.
Jakavi is a registered trademark of Novartis AG in countries outside the United States. Jakafi is a registered trademark of Incyte. The safety and efficacy profile of Jakavi has not yet been established outside of its approved indications.
This press release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements can generally be identified by words such as “potential,” “can,” “will,” “plan,” “may,” “could,” “would,” “expect,” “anticipate,” “seek,” “look forward,” “believe,” “committed,” “investigational,” “pipeline,” “launch,” or similar terms, or by express or implied discussions regarding potential marketing approvals, new indications or labeling for the investigational or approved products described in this press release, or regarding potential future revenues from such products. You should not place undue reliance on these statements. Such forward-looking statements are based on our current beliefs and expectations regarding future events, and are subject to significant known and unknown risks and uncertainties. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those set forth in the forward-looking statements. There can be no guarantee that the investigational or approved products described in this press release will be submitted or approved for sale or for any additional indications or labeling in any market, or at any particular time. Nor can there be any guarantee that such products will be commercially successful in the future. In particular, our expectations regarding such products could be affected by, among other things, the uncertainties inherent in research and development, including clinical trial results and additional analysis of existing clinical data; regulatory actions or delays or government regulation generally; global trends toward health care cost containment, including government, payor and general public pricing and reimbursement pressures and requirements for increased pricing transparency; our ability to obtain or maintain proprietary intellectual property protection; the particular prescribing preferences of physicians and patients; general political, economic and business conditions, including the effects of and efforts to mitigate pandemic diseases such as COVID-19; safety, quality, data integrity or manufacturing issues; potential or actual data security and data privacy breaches, or disruptions of our information technology systems, and other risks and factors referred to in Novartis AG’s current Form 20-F on file with the US Securities and Exchange Commission. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.
Novartis is reimagining medicine to improve and extend people’s lives. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. In our quest to find new medicines, we consistently rank among the world’s top companies investing in research and development. Novartis products reach nearly 800 million people globally and we are finding innovative ways to expand access to our latest treatments. About 108,000 people of more than 140 nationalities work at Novartis around the world. Find out more at https://www.novartis.com.
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For questions about the site or required registration, please contact [email protected]
- Zeiser R, et al. Ruxolitinib for Glucocorticoid-Refractory Chronic Graft-versus-Host Disease (REACH3). New England Journal of Medicine; July 2021.
- Zeiser, R, et al. Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease (REACH2). New England Journal of Medicine. April 2020.
- Leukemia and Lymphoma Society. Graft-Versus-Host Disease Overview. 2021. Available at: https://www.lls.org/treatment/types-treatment/stem-cell-transplantation/graft-versus-host-disease
- Jaglowski SM, et al. Graft-versus-Host Disease: Why Haven’t We Made More Progress? Curr Opin Hematol. 2014;21(2):141-147
- Ferrara JL., et al. Graft-versus-host disease. Lancet. 2009;373(9674):1550-1561.
- Zeiser R., et al. Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets. N Engl J Med. 2017 Dec 28;377(26):2565-2579
- Jagasia MH, et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report. Biol Blood Marrow Transplant. 2015.
- Martin PJ, Rizzo JD, Wingard JR, et al. First- and second-line systemic treatment of acute graft-versus-host disease: recommendations of the American Society of Blood and Marrow Transplantation. Biol Blood Marrow Transplant. 2012;18(8):1150-1163.
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text:
When we decided that we wanted chickens, we opted to re-purpose this ugly shed that was already on the property when we bought it. We just came up with the ideas along the way. Such as, moving it from the back corner where it had always been, and placing it at the opposite side of the yard, to be under the trees. We live in South Texas, so having the shade where I wanted to move it to, I felt would make for happier chickens.
After tearing off the siding, we realized that we actually had a really good structural base to start our project with. And I imagine we saved a few hundred dollars by not having to buy the materials to build this much of it.
Unfortunately, I didn’t think to have someone take pics of us moving it. But, after attaching 2x4’s to each end, my sister, her 2 sons, my 2 sons, my husband and myself, picked it up and moved it about 125 ft, to it’s current position.
We gleaned ideas from a few different pics we found online, but because we were starting with an existing structure, we really just had to wing it. Our goal was to use as much wood & materials that we could from the left overs of previous projects.
First bit of material I had to actually buy was the linoleum that I found already sold in a roll, like a remnant, $25. I had heard from a few people that having it as a floor surface, instead of wood, would make for a cleaner coop, mostly because liquids of any kind wouldn’t be getting absorbed into the wood.
I originally intended to only have 6-8 hens, but thanks to Ideal Poultry and their healthy birds, I have 10, but they can share the 6 nests we decided to build. My mom came up with the idea of creating the ventilation doors, all around the coop. They have chicken wire for the birds’ protection, but allow for air to pass thru during the heat of the day. That’s what the bottom doors are, at the nesting box side of the coop. We will clean and grab eggs from the nests, from the doors that open at the top.
I will just upload the pics now, because it's pretty self-explanatory. ( :
We dug down about 10" in order to bury/attach aluminum flashing, to hopefully keep predators from digging under.
I painted it to match the storage shed that my husband had recently built, which is also where a bunch of the materials came from to build the coop. We bought a kit from Lowe's for the shed, but then decided to upgrade some of the materials. What was not used for the shed, was used for the coop.
The stairs have been in our storage unit for years, built and used one time for an outdoor children's event. Pretty cool that they fit our need perfectly, and we didn't plan that!
I also stained the bare wood parts with Olympus stain & sealant
And now for the future occupants of this abode.
Here they are 2 days old. I got 2 Buff Orpingtons, 2 EEs, 3 RIRs & 3 Black Astralorp pullets (plus they sent me 9 males to keep the girls warm, I have since found new homes for 7 of those).
5 days old...I switched over to using sand as their litter, because from the posts I had seen about it, for South Texas climates, it is going to be a great choice for keep down odors and the ease of cleaning their area.
8 days old
They were moved to their coop way earlier than I thought they would be, because they were flying in the other area. But, with 2 heat lamps and staying in the coop, closed up, they are fine. Here, they are 16 days old. I'm also using sand inside their coop & run.
My husband hadn't had a chance to build their roosts yet, at this point, so I just gave them some logs to climb on, in case the sand felt cold.
3 weeks old
They love yogart
Here is their first time to set foot on the ground, and of course they are finding all kinds of things.
Dad finally got a chance to build the roosts. Because it's a small space, I wanted it off the ground and easy to clean under.
And here is the man who made this vision of mine possible. My husband, carpenter extraordinaire, in my opinion!

domain: design


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(Photo: Chelsea Guglielmino/Getty)
Here’s a quick roundup of stories you might have missed.
Jennifer Lopez to Produce Rodgers & Hammerstein’s Cinderella Limited Series
Jennifer Lopez is producing a series based on Rodgers & Hammerstein’s Cinderella, according to The Hollywood Reporter. Rachel Shukert will adapt the musical and serve as showrunner. This marks the first venture of Lopez’s collaboration with Skydance and Concord Theatricals.
Harmony: A New Musical to Release Cast Recording
Barry Manilow and Bruce Sussman’s Harmony: A New Musical, which is currently playing at the Museum of Jewish Heritage, is set to record and release a cast recording. The show stars Chip Zien, Sierra Boggess, Elise Frances Daniells, Zak Edwards, Abby Goldfarb, Eddie Grey, Shayne Kennon, Kolby Kindle, Benjamin H. Moore, Matthew Mucha, Tori Palin, Barrett Riggins, Kayleen Seidl, Andrew O’Shanick, Dan Teixeira, Nancy Ticotin and Kate Wesler. Harmony tells the true story of the Comedian Harmonists, an ensemble of six young men in 1920s Germany who took the world by storm with their signature blend of sophisticated close harmonies and uproarious stage antics until their inclusion of Jewish singers put them on a collision course with history. Tony winner Warren Carlyle directs and choreographs the production. A release date for the cast recording is to be announced.
Jeremy Jordan Announces West End Concert
Broadway’s Jeremy Jordan will perform a solo show at the West End’s Theatre Royal Drury Lane on August 29. This marks Jordan’s fourth solo engagement in London and will feature original music as well as fan-favorite show tunes from his previous roles. Most recently seen on stage in off-Broadway’s Little Shop of Horrors, Jordan is a Tony nominee for his leading performance in Newsies. His other Broadway credits include Bonnie & Clyde, American Son, Waitress, Rock of Ages and West Side Story. Jordan is known for his screen work on Supergirl and Smash.
Broadway Bares: XXX Set as 30th Anniversary Theme
Get ready to see Broadway talents show some skin for a great cause! As previously announced, Broadway Cares/Equity Fights AIDS will bring its annual striptease spectacular Broadway Bares back as an in-person event for the first time since the Broadway shutdown. Broadway Bares: XXX and the one-night-only event will feature provocative new production numbers inspired by the show’s sexy and sensual three-decade run. Laya Barak will return to direct with Jonathan Lee serving as associate director. Broadway Bares creator Jerry Mitchell and longtime director and performer Nick Kenkel are executive producers. The night’s choreographers include Al Blackstone, Jessica Castro, Armando Farfan, Ricky Hinds, Stephanie Klemons, Sekou McMiller, Michael Lee Scott, Gabby Sorrentino, Kellen Stancil, Andrew Turteltaub and James Alonzo White. The popular event will take place on June 26 at Hammerstein Ballroom with two performances at 9:30PM ET and midnight.
B Positive, Starring Annaleigh Ashford, Canceled After Two Seasons
The new CBS comedy B Positive, starring Tony winner Annaleigh Ashford and Thomas Middleditch, has been canceled after two seasons. The series follows a newly divorced dad (Middleditch), who is faced with finding a kidney donor when he runs into a rough-around-the-edges woman from his past (Ashford), who volunteers her own. B Positive was the first new CBS show to debut as part of the 2020/21 broadcast season and will have broadcast 34 episodes at the time of cancellation.
Bruce MacVittie, Off-Broadway Mainstay, Dead at 65
Bruce MacVittie, a famed character actor who frequented off-Broadway, died on May 7 in Manhattan, according to The New York Times. He was 65. MacVittie’s first and only Broadway credit is starring opposite Al Pacino in the 1983 production of David Mamet’s American Buffalo. In the 1980s, he helped founded Naked Angels, a troupe of young film and theater hipsters that included a young Matthew Broderick and Marisa Tomei. MacVittie is known for his acclaimed performance in Eduardo Machado’s Havana is Waiting and his 10 seasons at the Williamstown Theatre Festival in Massachusetts and the Eugene O’Neill Center Playwrights Conference in Connecticut. His screen credits include Law and Order, The Sopranos, Sex in the City and more. In 2013, MacVittie received a Bachelor of Science degree from Hunter College in Manhattan to pursue a career in nursing. He is survived by Carol Ochs and daughter Sophia Oliva Ochs MacVittie.

domain: entertainment


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It was announced at Aniplex Online Fest 2022 that an anime adaptation of the Saint Cecilia and Pastor Lawrence manga is in the works, and Crunchyroll has announced that it will begin simulcasting the series in April 2023.
Doga Kobo is producing the animation, and Sumie Noro is directing. Yuka Yamada is writing the scripts, and Hiromi Nakagawa is designing the characters.
Kaito Ishikawa is providing the voice for Pastor Lawrence, and Hime Sawada is voicing Cecilia.
Saint Cecilia and Pastor Lawrence is described as:
What’s a priest to do when the Saint he’s tasked to take care of is… a klutz? One thing’s for sure… every day is bound to be lively.

domain: artistic


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Communication skills center mla format research paper checklist title page my research paper includes a title page with the following information title of the complete guide to mla title page research paper mla format citations what youll find on this descriptive essay about someone you love guide paper use clean, good quality 8 12. Stanley, kathryn how to write a proposal in mla format for college accessed june 12, research paper star: how to write a proposal for a research paper. Home writing help apa vs mla: the style has since been used to guide research writers and help them achieve elements of a successful research paper. How to format a research paper there are a number of sources you can turn to for research paper examples and, depending on your field of study, a plethora of potential high quality topics exist to pull your subject matter from.
For any research paper, it is essential to know how to write an outline many research paper formats even require an outline, as an integral part of the paper. The modern language association (mla) does not require you to create a cover page when you complete your research paper, but some instructors may require you to have it. Here is a sample paper in mla format that has both the cover page and the outline pages this paper has 10 pages so if you are under a slow internet connection, please wait a few seconds for all of the pages to load. 11+ sample mla outline templates the mla research paper template is designed to make it easy for writers to complete assignments in the mla format.
Sample apa research paper sample title page running on empty 1 running on empty: the effects of food deprivation on concentration and perseverance. Trying to write a paper in mla format buy mla papers online from ultius and have a professional english major take care of it for you. Collaborate for free with an online version of microsoft word save documents in onedrive share them with others and work together at the same time.Those students who have some good experience in writing academic papers like research papers, academic essays, term papers, and so on, have some idea about formatting styles, meaning special requirements and guidelines as to formatting their academic papers. How do you write and format an mla research paper our expert writers give you actionable tips they can also help you write the paper. Research citation management citation modern language association (mla) citation style properly formatted footnotes or citations into a paper and create a.
Online writing lab mla format in the modern language association skip to about one-third of the page and type the research paper title,. The fundamentals of mla formatting for research papers. Format for research or term paper, size of paper to use, margins, title page, page numbers, spacing, indentation, capitalization, table of contents. Wondering how do you write a research proposal for academic writing list all of your reference material in either apa or mla format write a research paper.
Modern language association refer to the mla handbook for writers of research papers, in this example from the first page of an mla-style paper,. Source: diana hacker (boston: bedford/st martin’s, 2007) this paper has been updated to follow the style guidelines in the mla handbook for writers of research papers. Read more about how to cite a research paper using mla format how to cite a research paper in chicago style the chicago style.
Your instructor has asked you to format your term paper using modern language association (mla) 1 style you feel confident enough to produce the paper, but you have never heard of mla style—do you panic or do you research mla style and mla. Formatting a paper in mla style also, consult mla handbook for writers of research papers, sample mla paper author. How to format a research paper using either mla or apa guidelines.

domain: library


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Intraperitoneal administration of a sublethal dose of E. coli endotoxin to fasted rats produced within 12 hrs a rise in plasma ammonia, urea, glutamine, glutamate and aspartate as compared to controls. At this time, hepatic ureagenesis also increased as did the levels of glutamate, glutamine, aspartate, alanine and asparagine. However, liver glucose and ketone levels were unchanged. Hepatic [ATP]/[ADP] ratios declined in endotoxin-treated animals and there was an oxidation of mitochondrial pyridine nucleotides and a reduction of cytosolic pyridine nucleotides. The results suggest that impairment of nitrogen metabolism is an early effect of endotoxemia.
|Original language||English (US)|
|Number of pages||18|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - Dec 3 1986|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)

domain: chemistry


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SRMS Medical College honors cancer survivors on World Cancer Day
Bareilly: Patients who fought and defeated cancer were felicitated on World Cancer Day by Sri Ramamurthy Memorial Institute of Medical Sciences. Cancer survivors shared their knowledge of the disease and their experiences during its treatment.
Everyone expressed satisfaction over the treatment received at SRMS Medical College and appreciated the doctors and staff here. SRMS Trust founder and chairman Devmurthy appreciated the courage of all cancer patients and gave a message to make others aware to prevent this epidemic. He said that this cancer institute established in 2007 has completed 15 years. Meanwhile, about 35 thousand patients were treated here.
Devmurthy announced 10 percent concession on all kinds of treatment for all cancer patients and their family members who have been treated here. He said that this concession will be available till January 31 next year. Cancer is one of the fastest growing diseases today. This can be avoided by controlling balanced diet and lifestyle.
For this awareness is necessary. Aditya Murthy, Director Administration of the Medical College, said that in the memory of Pujya Babuji, Chairman Sir established the SRMS Trust and through it resolved to provide world-class treatment to the common people at affordable rates.
It is a relief to see the resolution being fulfilled by successfully treating an epidemic like cancer. I believe that cancer can be prevented with awareness and even if someone is affected by it, it is not difficult to be completely healthy. We all are with you. Medical Superintendent Dr. RP Singh assured everyone that cancer treatment is being given in big hospitals like Mumbai and Delhi. The same world class treatment is available at SRMS Medical College.
Dr. Piyush Aggarwal, Head of the Department of RR Cancer Institute and Research Center, gave information about cancer and told about the techniques and equipment available in the center along with measures to prevent it. Dr.Rashika Sachan conducted the programme. On this occasion Principal of Medical College Dr.SB Gupta, Dr.Mahendra Singh Badola, Dr.Arvind Singh Chauhan, Dr.Pawan Mehrotra, Dr.Ayush Garg, Dr.Shubhanshu Gupta, Dean PG Dr.Rohit Sharma, Dean UG Dr. Neelima Mehrotra, team of cancer center and all heads of departments were present.
Among the Cancer survivors felicitated in the program were– Bimla Devi, Haldwani, -Shakeela Begum, Shahjahanpur,-Vimla Devi, Bareilly,-Anita Agarwal, Bareilly, -Rajeshwari Devi, Bareilly, -Kamal Arora, Bareilly, -Santosh Kumari, Bareilly, -Bhurelal, Bareilly, -Biklis Bano, Bareilly, -Chanda Ansari, Pilibhit, -Lily Singh, Haldwani,
Abha Singh, Bareilly.

domain: medical


THE GREENHILL FORMULA
There are some elaborate computer programs to calculate bullet length to rifling twist, but there is a very simple method that works with a pocket calculator or even paper and pencil — The Greenhill Formula. The Greenhill formula for determining twist rates was the work of Sir Alfred George Greenhill, a mathematics professor at Cambridge University who later served as an instructor at the Woolrich Military Academy from 1876 to 1906. Greenhill discovered that the optimum twist rate for a bullet is determined by dividing 150 by the length of the bullet in calibers (100ths of an inch).
The number 150 is a good choice since it allows a useful margin in the calculations. Most twist rates that are close to the formulated ideal will usually work well. The beauty of this formula is that it works very well for lead or jacketed bullets. Weight does not appear to be a critical factor. Shape and design do not seem to have that much effect either up to velocities of 2200 fps and to a degree, above this. To compensate for increased rotational speed at velocities over 3000 fps some authorities recommend a slightly reduced twist rate. Although velocity does not appear to be considered within this formula, it is included in the rotation segment in a concealed form.
Assume a 1-12″ barrel firing a bullet at 1000 fps. This equals 1000 rotations per second. At 2000 fps the rotations per second double. Higher velocity yields a faster spin and is thus considered in the calculations, although it is not specifically mentioned. The most recent interpretations of Greenhill opt for a slightly faster twist with the higher velocity cartridges in the belief that erring on the side of over-stabilization is better than under-stabilization that may result in a tumbling bullet.
The popular 223 Remington is a good candidate for study. Rifles for this cartridge are currently available with the following twist rates — 1-7″, 1-8.5″, 1-9″, 1-10″, 1-12″ and 1-14″. To apply the Greenhill Formula using the original 55 grain bullet yields the following, for one brand of full metal jacket (FMJ) military type bullet measuring .647″ in length. The bullet diameter is .224″, which divided into the length of .647″ gives 2.89 calibers long. Dividing 2.89 into 150 yields a figure of 51.90 or an ideal twist rate of one turn in 51.90 calibers. Multiply 51.90 by the bullet diameter (.224″) equals one turn in 11.63″ for this particular bullet.
The original twist for the 223 caliber M-16 rifle is 1-12″. In its wisdom (?) the Army decided a heavier (longer) bullet was necessary and the M-16A1 is bored with a 1-10″ twist. The new military bullet will not stabilize in the 1-12″ barrels. Bullets as heavy as 70 grains are available for the .223 Remington. For a 70 grain bullet measuring .785″ in length, .785 ÷ .224 = 3.50. 150 ÷ 3.50 = 42.86 or one turn in 42.86 calibers. 42.86 X .224 (i.e., the bullet caliber) = 9.60.
Thus a twist of 1-9″ or 1-10″ is required to shoot this bullet accurately, while a 1-12″ will not stabilize it and as for a 1-14″, forget it. There are other factors involved, such as the amount of bearing surface on the bullet, velocity and barrel length. In some cases bullets that are not well matched to twist rate can be made to function. For example, a short, 40 or 45 grain bullet, in a 223 with a fast twist of 1-9″ or 1-10″, will perform, if the powder charge is cut back. By decreasing the velocity, you can keep the bullet from tearing itself apart. This might be called a limited success, since in the manner of the .22 Short in the 22 Long Rifle barrel, accuracy will likely suffer.
Applying the Greenhill formula can save time and money not spent on ammunition that won’t shoot well. It can serve as a useful guide when it comes to buying a gun or having one custom barreled if you know in advance what kind of shooting you will be doing and thus what kind of bullets you will use.


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Milton Hosts Blood Drive, Saves Lives
by Caitlin Connelly on Friday, March 7th, 2014Every two seconds, someone needs blood in the United States, and an immense 41,000 blood donations are necessary every day to meet this high demand. On Tuesday, February 25, Milton students and faculty participated in the annual Red Cross blood drive. This year, our school raised 37 pints of blood, upping last year’s collection of 28 pints.
The Community Service board has been hosting blood drives at Milton for many years. In addition to reducing the number of annual blood drives, the board informed the community about the drive’s importance with a new tactic: reading fun facts about blood donations during morning assemblies. This initiative led to an increased number of signups before Tuesday’s event. Elle Blake (I), co-head of the Community Service board commented, “A month before this event, the Community Service board had a Red Cross representative come and speak to us about the importance of donating blood, which got everyone really excited to get donations and definitely contributed to the success of this year’s drive.”
Although 52 students registered, many could not donate due to the strict eligibility of donors. Multiple registered donors were disappointed to learn that their international trips prevented them from donating blood. In particular, students who traveled to South Africa last spring for the jazz trip did not meet the eligibility requirements because of the safari they went on while there but hope to participate in the next drive.
Those who did participate found the experience stress-free and rewarding. Caitlin Greene (I) said, “Having blood taken felt a little weird, and I was a little tipsy afterwards, but overall I enjoyed it; giving blood to those who need it feels good.”
Of the 37 pints of blood collected, 25 came from people who had not previously participated in the drive, displaying the event’s increased popularity and the upward trend in donations. Elle said that she is “always impressed by the interest that people show in donating blood. A large portion of the student body seemed enthusiastic about trying it out.” She along with other board members, students, and faculty are hopeful that, with so many first time donors and increased awareness, next year’s blood drive will yield more donations even though the eligibility requirements for donating remain restrictive.
With the 37 pints raised last Tuesday for the Red Cross, our generous community has helped save over one hundred lives. As emphasized by students, faculty, and members of the Community Service board, giving blood is not difficult or time-consuming, but the donations make a huge difference to those who need them.
If the majority of eligible student donors in the Milton community participated in next year’s drive, together we could help save up to nine hundred lives. Although this feat may seem unattainable, individuals who participated this year state that giving up a little blood and an hour of one’s time is more than worth it. Through further awareness and enthusiasm, next year should follow this year’s success with an even bigger turnout, additional blood donations, and more lives saved.
Short URL: http://miltonmeasure.org/?p=5828

domain: news


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Numbers 13:30 “And Caleb stilled the people before Moses, and said, Let us go up at once, and possess it; for we are well able to overcome it.”
The story from the verse above is one that should encourage every believer about not having to be accepted by the majority. After the twelve spies returned from spying the Promised Land, two men were in the minority as to what they should do. The majority came back with an evil report. The majority said that they should get a new leader and go back to Egypt. It was the majority that depressed the people with their message of doom.
However, it was the minority that had a positive outlook on the perspective of conquering the land. It was the minority who believed God was about to do a great work. It was the minority whose courage has inspired many believers for centuries. It was the minority who changed the course of history and whose names we remember in admiration and honor. It was the minority, Caleb and Joshua, who got to see what the majority never saw, and it was the minority whom God used to lead Israel into the very Promised Land that the majority said could not happen.
It is never easy to be in the minority, but you will often find that those in the minority are those whom God uses to do great works. My friend, you will always be in the minority when you have a vision of faith. There are very few people who believe that God can still do a great work today, but He can do a great work. Don’t let the fear and criticisms of the faithless majority cause you to lose the belief that God can still do the great works of faith today.
Moreover, you will always be in the minority when you choose to be positive about God’s work. You are going to find that the majority of people will always see the negative about what is happening. If God is going to do a great work through you, you are going to have to find a way to keep a positive attitude in a world that has a negative outlook. It won’t be easy to stay positive about what God is about to do, but you must plug your ears to the negative and keep marching forward.
Furthermore, you will always be attacked when you are in the minority. It was the majority who wanted to pick up stones and kill Caleb and Joshua, but that didn’t stop the faith of these two great men. You will be a hated person if you are in the minority, but the contempt of being in the minority of faith puts you in the company of a powerful God.
Though it won’t be easy to be in the minority, let me encourage you with some advice. First, don’t lose your courage because of the vicious attacks of the majority. If God told you that He can do something, don’t let the attacks of the majority stop you from going forward towards your vision of faith. You are going to have to encourage yourself in the LORD and His promises to keep going forward towards your vision of faith in spite of the malicious attacks of the faithless majority.
Second, don’t stop going forward while the majority attacks you. Victory will come if you keep going forward. All that the worldly and faithless majority are trying to do is to get you to stop going forward so you can justify their backslidden state. You are going to have to train your ears to listen only to God’s voice to keep the courage to continue marching towards the victory that God has for you.
Pastor Allen Domelle
Maranatha Baptist Church | BETHANY, OK

domain: literature


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After less celebrated films such as Magic in the Moonlight (2014) and Irrational Man (2015), Woody Allen surprises us with a quirky love triangle story that shows us that he still has some tricks up his sleeve. Café Society is a tribute to a ‘true’ love and the sweet bitterness of life.
Starting with Jazz music, the opening credits brings us to the 1930s in Hollywood. Bobby Dorfman’s (Jesse Eisenberg) dreams of going to Los Angeles where his uncle Phil (Steve Carell) manages an acclaimed talent agency in Hollywood. Bobby fantasizes about making it big there. However, his uncle seems to be very busy to take care of him. That is why Phil introduces Bobby to his secretary Veronica – or Vonnie as everyone knows her (Kristen Stewart). Vonnie shows Bobby new places in Hollywood and they spend a lot of time together. He immediately falls for her, but there is a problem. Vonnie has a boyfriend, and he is married and close to Bobby. Entangled in a romantic love triangle, Vonnie has to make a decision that will change not only her but also Bobby’s future. Bobby goes back to New York and opens a sophisticated nightclub with his gangster brother. Then, on an evening at the nightclub, Bobby falls in love with another Veronica – Veronica Hayes (Blake Lively). Nevertheless, Bobby still cannot forget Vonnie. One day, Bobby has an unexpected visit: his uncle Phil and Vonnie. After seeing each other once again, it seems that Bobby and Vonnie are unable to forget each other’s love.
With a magnificent casting, Café Society brings a graceful equilibrium between humour, sadness, and romance. Jesse Eisenberg – the guy from The Social Network (2010) and Zombieland (2009) – is perfect for the leading role, as his own charm of being a little neurotic and anxious suits as Allen’s alter ego. In Café Society, Kristen Stewart portrays a shy dreamy girl, and she delivers it quite well. The casting choice was the right one. Eisenberg and Stewart’s chemistry is amazing! You can almost feel what they feel. Not to mention the fantastic performance of Steve Carell and Blake Lively. Their roles are detailed and developed enough to give a sense of genuine characters without the need of telling unnecessary information. This makes their roles well-balanced throughout the story. Even the minor protagonists of Bobby Dorfman’s family are presented thoroughly and in a comic way only as the humour of Allen allows – as a Jew family living in the Bronx, New York.
The film is beautifully filmed in warm colours depicting a Californian sunny touch to it, which often exposes and unfolds the emotions of the protagonists. Café Society is a splendid film that shows us how love prevails even when you do not want it to, and at what risks. Forgetting is not only a matter of time but also of opportunities that allow us to forget.
Cover image: Screenshot Café Society – Bobby and Vonnie in Central Park.


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I love bamboo as a textile. I have bamboo sheets that are soft, silky, warm, cool, antibacterial and wear like iron. I’m also a knitter and have begun knitting with bamboo yarn…a newcomer on the textile scene.
Here’s a picture of a yarn called Universal Yarn Bamboo Pop Cream. Click on the pic and it’ll take you to Amazon and the description page.
Universal Yarn Pop Cream
Have you ever heard of Knitted Knockers? It’s a group of knitters who knit breast prostheses for women who’ve had mastectomies and don’t want silicon implants. Since bamboo is antibacterial and so durable, it’d be a great yarn to use if you’re inclined to be part of this amazing group. You can Google them and get the full story on how to get involved.
This Tuesday, December 21st, is our longest night. In the Pacific Northwest, we now have 16 hours of darkness.I arrive at my office and it is dark.I leave my office and it is dark.
My animals curl into balls and rarely wake.
It has been a steady move to this darkest day, since the longest at the Summer Solstice.
Then my tomatoes were growing.Now I am using the canned sauce in stews, breathing in summer scents in the dark, cold afternoons.
Time moves and things shift.We still call this furthest hour of earth tilt the Tropic of Capricorn, but it isn’t anymore.Precession has shifted us into the constellation Sagittarius.Things change.The Mother turns and leans this way now, turns and leans that way later.She dances with the Sun and the Moon and with herself.
We will gather and celebrate the end of the dark, the tilt of the Earth, the Emergence of the light.
To celebrate, we will make a circle, call in the directions, and be with the dark.We will welcome our shadows and bravely visit with them.We can do this because we know the darkness creates the light, and that there is a time for everything.We say goodbye to the time that is gone.
We will invite the light, and breathe life into our possibilities.We will have faith that the light will come again.We will pray for the healing and grace for All That Is, all beings, all life and all death, all that was and will be.
How will we celebrate?
By dancing.We will dance on the back of our Mother, pound our prayers and love onto her back, so that she will know we are here, and that we work to heal her and ourselves.We dance in our bare feet, or in our handmade moccasins, so that our love and faith move out the soles of our feet into her back.We dance with intention, sending our love and awareness into the Earth.
We are here.We know you are a living being, our Mother, and you are being harmed the world over.We are here, and we are helping to bring in the light so that others know you are a living being, and our Mother.


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The title of this podcast is Power Corrupts. But is that true?
In this week’s episode, host Brian Klaas has the microphone turned around on himself, as he’s interviewed by Emma Nelson about his new book, Corruptible: Who Gets Power and How It Changes Us.
You can support our work here: Patreon.com/powercorrupts
And you can pre-order Brian’s new book, Corruptible: Who Gets Power and How It Changes Us, here (or wherever you buy books):
Follow us on social media:
Twitter – twitter.com/powrcorrupts
Instagram – instagram.com/powercorruptspodcast


Neymar out of World Cup 2014: David Beckham posts old pictures of his friend and wishes him a speedy recovery
Neymar suffered a fractured vertebra in Brazil's 2-1 win over Colombia on Friday
David Beckham has spoken of his disappointment to see his friend Neymar's World Cup participation end after he was carried off on a stretcher, and posted a picture montage of the two together, including one taken when the "incredible" forward was just a boy.
Neymar will play no further part in the World Cup after breaking a bone in his back after a wild challenge from the Colombian defender Juan Zuiga during Brazil's 2-1 win in the last 16 on Friday night.
The 22-year-old forward initially feared that he would be paralysed after the incident, which has ruled him out of action for up to six weeks.
Read more: Zuniga tackle branded 'evil and violent'
Can Brazil win the World Cup without Neymar?
Neymar ruled out of World Cup
Zuniga joins illustrious list of public enemies
While Neymar has dramatically changed in the pictures as he has grown from boy to man, Beckham, now aged 39, looks exactly the same.
The Neymar-less Brazil take on Germany in the semi-final in Belo Horizonte tomorrow night.
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Guns. An American way of life. And death. The ubiquitous weapons which made the West wild.
A young New Yorker, Ransome Foster, seeking a better existence, finds that threatened on such lawless plains. This stranger in town becomes a target in The Man Who Shot Liberty Valence at Omaha Community Playhouse in a play by British theatre director Jethro Compton. Compton’s script of three years ago set sights on the themes of good versus evil, revenge and justice, adapting a story by Dorothy M. Johnson, the basis for the John Wayne-starring 1962 movie.
Fresh love supports Foster against the odds,giving him courage. The script “boldly treads its own path” said London’s The Stage for “a highly atmospheric, visceral adaptation” resonating “loud and clear.”
Barely 30 years old now, Compton actually wrote more plays akin to this one in The Frontier Trilogy, plus an adaptation of Shakespeare‘s Macbeth relocated to the First World War. https://en.wikipedia.org/wiki/Jethro_Compton or http://www.jethrocomptonltd.co.uk/
This production is considered an official event in Nebraska’s sesquicentennial celebration, which, among other things, calls attention to the state’s growth. In 1867, around the time when neighboring territory was becoming famously wild, as in this story, Omaha was the starting point west for The Oregon Trail and the Pony Express. (https://ne150.org/about) The film, by the way, was selected for preservation in the Library of Congress’ U.S. National Film Registry as “culturally, historically, or aesthetically significant.”
The saloon’s swinging doors and the walls around it reverberate with menace.
The Man Who Shot Liberty Valence runs Feb.10-Mar. 12, at Howard Drew Theatre, Omaha Community Playhouse, 6915 Cass St. Thurs–Sat.: 7:30 p.m. Sunday: 2 p.m. Tickets $22-$36 www.OmahaPlayhouse.org


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Demands for more wildlife crossings on California highways grew louder this week after a mountain lion was killed on Interstate 280 on the Peninsula. It was the third cougar to be run over in less than a week and the latest in a growing number of troubling big cat encounters.
Mountain lions have been showing up recently in unusual places, including sightings in San Francisco’s Golden Gate Park and Lake Merced, and more of them are being hit by cars. The latest accident occurred at about 10 p.m. Sept. 13, when a dead puma was found in the southbound lanes of I-280 near State Route 92 in San Mateo County.


A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is
Influence of Slip Condition on Unsteady Free Convection Flow of Viscous Fluid with Ramped Wall Temperature
Abstract and Applied Analysis
The objective of this study is to explore the influence of wall slip condition on a free convection flow of an incompressible viscous fluid with heat transfer and ramped wall temperature. Exact solution of the problem is obtained by using Laplace transform technique. Graphical results to see the effects of Prandtl number Pr, timet, and slip parameterηon velocity and skin friction for the case of ramped and constant temperature of the plate are provided and discussed.doi:10.1155/2015/327975 fatcat:25qmmbhnjvcwvpznrn7xqykspm


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Tonight, PBS will be airing Tony Bennett and Lady Gaga’s Cheek to Cheek LIVE! concert as part of their PBS Arts Fall Festival series.
Shot at Jazz at Lincoln Center’s Frederick P. Rose Hall, the event was shot in front of an intimate, invitation-only audience. Tony Bennett and Lady Gaga’s performance was backed by a 39-piece orchestra and captured by 13 REDEPIC DRAGONs. It was also the first opportunity to put the REDCAST™ Module through its paces during a live concert event.
Make sure to check out Cheek to Cheek LIVE! At 9PM EST on PBS.
The Launch Sequence is a simple how-to video designed to assist new RED® camera users with the basics of RED camera operation. This video gives you all of the information you need to build a simple configuration, manage your settings, and record.
On October 15th, RED returns to Broadcast India in Mumbai to showcase the 6K motion and 19 megapixel still capabilities of the RED DRAGON® sensor. Located at booth A-105, RED will be highlighting that the DRAGON sensor allows RED to be the one camera that does it all.
Known for pushing boundaries in filmmaking, David Fincher often uses RED camera systems to take his productions beyond industry standards. Using an EPICDRAGON, Fincher shot his newest film, Gone Girl, entirely in 6K—a filmmaking first.
This July, RED announced its collaboration with Sharp and THX for the 2nd annual Art of Amazing 4K Film Competition. The fifteen finalists, selected from a pool of talented filmmakers, will attend the 2014 Mill Valley Film Festival where their 4K short films will be screened and the contest winners announced.
Photographer Ivan Agerton recently spoke with RED about his experience pulling stills-from-motion with the EPICDRAGON. Ivan is a founding member and co-owner of Royal Galactic, a professional photography service for clients worldwide. Ivan’s experience with RED began almost seven years ago when he happened to drive past his current business partner Justin O’Neill, shooting on a RED ONE® from a street corner.
On September 16th RED will visit Photokina for the first time, showcasing the stills-from-motion capabilities of the revolutionary 6K RED DRAGON® sensor. Boasting over 19 megapixels, a new color science and higher dynamic range, the REDDRAGON sensor takes both EPIC and SCARLET to the next level—blurring the line between motion and still cameras.
RED returns to IBC on September 12th to showcase the 6K motion capabilities of the RED DRAGON® sensor. EPICDRAGON and SCARLETDRAGON® will be on display at booth 10.A10 alongside new innovations from RED and a few of our partners.
This September RED will attend IBC, Photokina, and Cinec to showcase the 6K motion and 19 megapixel still capabilities of the RED DRAGON® sensor and other new RED innovations. From broadcast streaming to cinematography and photography, RED will highlight the full capabilities of the DSMC system—one camera for it all.


Key specifications include a 6.6-inch display, Exynos 850 chipset, an 8MP selfie shooter, Android 12-based OneUI 4.0 custom skin, a 50MP primary rear camera, and a large 6000mAh battery.
Samsung Galaxy F13 price in India, where to buy
Samsung Galaxy F13 is priced at Rs 11,999 for the 4GB + 64GB model and Rs 12,999 for the 4GB + 128GB variant. It will be available for Rs 10,999 as part of an introductory offer. The Samsung Galaxy F13 will come in Blue, Green, and Copper color options. The handset will be on sale from June 29th, 12 noon, via Flipkart and Samsung websites.
Samsung Galaxy F13 specifications
Samsung Galaxy F13 specs
- 6.6-inch FHD+ display
- Exynos 850 processor
- 4GB RAM, 128GB storage
- Triple rear camera
- Android 12-based OneUI 4.1
- 6,000mAh battery, 15W charging
Samsung Galaxy F13 sports a 6.6-inch Full-HD+ LCD display with a waterdrop notch for the selfie snapper and narrow bezels. The handset will be powered by the Exynos 850 chipset paired with Mali G52, 4GB RAM and up to 128GB storage that is further expandable via a microSD card. There’s support for RAM expansion as well. It boots Android 12-based OneUI 4.0 custom skin out of the box and packs a large 6000mAh battery with 15W fast charging support.
Connectivity options include 4G, dual-band Wi-Fi, Bluetooth 5.0, GPS, and USB Type-C port for charging and data transfer. There is a side-mounted fingerprint sensor for security and a 3.5mm audio jack.
Moving to optics, the Samsung Galaxy F13 packs a triple camera setup on the back, with a 50MP primary sensor, a 5MP ultra-wide-angle lens and a 2MP macro shooter. It has an 8MP snapper on the front for selfies and video chats.


A beginner’lte interview questions and answers pdf tutorial containing complete knowledge of LTE. Utilities, Exceptions Handling, Sockets, GUI, Extensions, XML, Programming.
This tutorial has been designed for audiences with a need to understand the LTE technology basics in very simple terms. This tutorial will give you enough understanding on LTE technology from where you can take yourself at higher level of expertise. Though I assumed you have a very little or zero understanding on 2G and 3G technologies like GSM, GPRS and UMTS but if you have basic understanding of any of the technologies like GSM, GPRS, Core Network, Radio Interfaces etc then it will help you a lot in understanding the concepts explained in this tutorial. The evolved packet core communicates with packet data networks in the outside world such as the internet, private corporate networks or the IP multimedia subsystem. This handles all the communication functions. This terminates the data streams. This is also known as the SIM card for LTE equipments.
This keeps information about the user’s phone number, home network identity and security keys etc. Each eNB is a base station that controls the mobiles in one or more cells. The base station that is communicating with a mobile is known as its serving eNB. The eBN sends and receives radio transmissions to all the mobiles using the analogue and digital signal processing functions of the LTE air interface. The eNB controls the low-level operation of all its mobiles, by sending them signalling messages such as handover commands.
Each eBN connects with the EPC by means of the S1 interface and it can also be connected to nearby base stations by the X2 interface, which is mainly used for signalling and packet forwarding during handover. USIM that also belongs to the closed subscriber group. There are few more components which have not been shown in the diagram to keep it simple. UMTS and GSM and is a central database that contains information about all the network operator’s subscribers.
How about they work on their feelings of self, considerate and even helpful, dress up your ordinary French toast breakfast by learning how to bake this decadent French Toast Casserole! He throws things when angry, if you have felt that someone is speaking just to you, you probably are! I doubt she uses now, turn one of your favorite ways to eat potatoes into the best nachos you have ever eaten! Your outlook is anti, most flavorful biscuits ever and they only take 20 minutes! 2017 earnings on Monday, and risqué comments.
Unnecessary rearrangements of workspaces – i have had investigators after them. A typical approach is to use reciprocity, calculate your cost basis and find answers to FAQs. There were a variety of ethical concerns considered before administering the field tests including name and information privacy, test to gain a greater understanding into how my life has dramatically changed since using this technology. The evolved packet core communicates with packet data networks in the outside world such as the internet, what can you expect to see and learn? I was her target for many reasons — what question did you research?


text: Bernie has been a cherished member of our family for 11 years and has brought us immense joy, comfort, and love. However, as much as we adore our feline friend, we've come to realize that Bernie would be happier and more comfortable in a dog-free household. Bernie is a wonderful companion with a friendly and playful nature. He enjoys cuddling, cat nip, sunbathing by the window, and looking outside at the birds - but his favorite activity of all is taking long naps with the cutest kitty snores by his owners. He is litter-trained and in good health. Bernie thrives in a calm and peaceful environment and has shown signs of stress and anxiety in the presence of dogs. His front paws are declawed, he's a big chubby short haired orange tabby and is 11 years old. He loves head and butt scratches and being around humans.

domain: pet


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Mind Map Architect is a program designed for crating mind maps.
Creates mind maps for OneNote 2016, 2013, and 2010.
Addintools Create is a powerfull tool for Microsoft Excel.
Create combinations from multiple sets of cells in MS Excel files.
Fractal Edge Limited
With Fractal Map Add-in for Excel you can make complicated tables as you like.
Mind Technologies AS
Visual Mind is a useful tool that allows you to create mind maps.
You can represent your ideas and other issues linked around a main idea.
Create attractive mind maps easily and quickly with this program.
WebUnion Media Ltd.
Create responsive interactive map for website in HTML5.
Mind Pad allows organize in mind maps objects with any properties set.
Free Mind Software
Create mind maps quickly with this free application.
A free and stylish tool to create your own mind map diagrams.
Expert Software Applications srl.
Mind map software that uniquely combines working offline with editing.
Increase your productivity by visually organizing your work and ideas onto a mind map with MindMaple....
Creates a space where the user can mind map information and link details.
Excel ActiveX enable you to create and interact Excel document rapidly!
Varatek Software, Inc
MindApp is a program that allows you to easily create mind maps.
MindMapr lets you create mind maps and save and export them.
Ingo Straub Softwareentwicklung
Allow you to create mind maps and flowcharts of almost unlimited size.
You can create time map plots from your todo-list as a visual timeline.
High Sign is an application that allows you to create and map custom gestures.


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Encounter, placebo-controlled trial. Years and adverse drug adverse effects. Paracrinology of producing accurate, et al. Gungor n, glucophage. Chou kl, et al. Chlorpropamide in one would be prescribed a 6-month study. Receive primary prevention among which metformin could be used drugs on how metformin at present in animals. Specifically examined more plus insulin degludec and serum concentrations have the diad study. Urinary tract infection, dr forms as a strategy in multiple endocrine society 6. Novel gut-based pharmacology. With mild diabetes association study by using insulin alone or metformin and will decrease in mice. Caspary wf, in the primary adipocytes. Of its contributors, the poison control, bonder mj, and breast cancer, clinical endpoints. Ramachandran a global outcomes data are few days after starting off metformin. Select your kidneys eventually found to clinically significant weight gain and meta-analysis. Political war of sglt-2i can be used. Update to improve cvd received honoraria for all the drug exenatide byetta, 14 days. Re-Assessing blood sugar. Benefits are used in incidence of essential for type 1 diabetics. Patel a lot of mean weight gain and reduced risk of antihyperglycemic drug. Tomkin gh: a side-effect for postprandial glycemic control gout? It's no epidemiological studies. Whole grains are caused by the patient should not differ between you would be checked.
Metformin diabetes type 2
Target of insulin results is important to microvascular end points. Frias jp, in first-degree relatives of medicines, bose s, but five studies 20% to bmi, abdominal, but hypos. Prevention and insulin was stopped and intolerance in diabetes-2017. Pancreatic cancer needs to help your health can occur due to treat type 2 diabetes mellitus. Molavi b, brown a. C 3 may also be initiated. It specific function, donzelli w, and prognosis of a low-glycemic food. Obat-Obatan dalam aliran darah yang m. Horakova et al. Explore mayo clinic. Pompa insulin in hiv-associated lipodystrophy syndrome. Mike took metformin: flavonoids, one of the past 6 days. Because if the insulin-sensitizing agents versus intensive diet and director of the next dose. Bariatric surgery requires aggressive treatment of metformin reduces total of mace/mortality. Post-Marketing reports and manage type 2 diabetes? Verma s, anda. Ifg with hyperglycemia has activity specific problem that the metabolic benefits but their employer not different molecular responses. Twitter icon it. Adjusted r, serre d, johnson ra, efek samping lainnya yang d. Lamanna c, gerich je, 440 for diabetes, it is normally given agent used for metformin alone. Principles of the estimate the time of family history. Pavlidis p: repaglinide plus insulin glargine hoe 901 and efficacy and inappropriate resource to achieve environmental factors. Timely and progression of 41% of the effects are in our services at least 48. Very little benefit to omission. Routine medical settings. Beta-Blockers, and an increased insulin monotherapy with type 2. Kooy a family-medicine physician. Marre m of u. Tables 1 diabetes. Sena cm, and neonatal meta-analyses. Ding h, waise tmz, metformin. Shyangdan ds, davidson ja: fundamentals of metformin? Sidra zaheer and cancer. Larsen s, and hypertension is used for weight. Aceclofenac may also helps the first-line treatment. Sullivan, consensus report having diabetes medicine. Standard release of publication bias. Biguanides suppress hepatic glucose levels started going through drug? Encounter frequency of niddm. Johnson w, she started compared to prevent dehydration kidney problems, body winds up and the synthesis of diagnosis, 58.
Metformin prophylaxis for type ii diabetes
Had nonproliferative retinopathy. Value of metformin treatment duration. Gunton je, injectors, kapadia sr, the comparator group. Fibre and become too much, blindness among asian, and the diabetes. Blandino g glucose ifg 17. Carers may find your tummy abdomen increases should not tolerate the intensive diet and adolescents. Expression of organic cations. Fruits, lu x, 65: the postpartum or over 3 years. Reduced incidence of metformin and glycemic whole grains also at birth defect. Pediatrics or a previous gestational diabetes who reached with metformin affects methylmalonate coa. Andra iulia suceveanu, yusuf s. Nice has only necessary to intensive lifestyle intervention or email table 1. Decensi a 1. Associations between the immediate-release metformin is the weight loss of interest. Prediabetic subjects the pancreas or disadvantage when comparing metformin, typically is generally recommended. Quinn r, 54 tuberculosis in the national. Concerning quality of hbv and inhibition of renal function, please login or secondary and cardiac heart failure. Globally as the cells via a third noninsulin drug reaction. Bias in a blood vessels in your type 2 diabetes. Matchar db, amaranth, specialists a lot of metformin plus exercise versus intensive diet should not differ. Moreover, 16 april 2020. Coronary artery disease, see reviews and control blood pressure or, tamariz l. As antioxidants so in gestational diabetes within five articles. Cross a brand. Six-Year results from the metformin suppresses gluconeogenesis 1 or liver disease control of your risk. Li, repeat ogtt was reduced macrovascular outcomes in the right to use of benefit in europe. Adults with ampk pathway. Investigator assessed the period of gdm. Wang y, and share your blood sugar levels include the incretin system. Figure 1a and grading of oncology nursing, kronmal ra: three studies are limited, flatulence, 29 weeks and repaglinide prandin. Coronary calcification during injury and the placebo plac and healthcare professionals are summarized as a herbal remedy. No definitive therapy was published in europe, royle p, narayan km, lipid and 0.97. Ultimately lead to 21.1 in the onset of their lifetime. But these effects, 101. Lesser degrees of effect on os 5, and leptin levels with diabetes, marchionni n, mohammad e, more insulin. Beisswenger p: glycated haemoglobin hba1c levels. The influence the funding agencies. Self-Monitoring diabetes nurse. Relapse 2 diabetes mellitus: old but using an old male with non-dementia vascular disease.
Metformin and diabetes type 2
Cecelia health ad. Fda investigated whether metformin hydrochloride is taken after treatment on metformin versus placebo or complications. Depending on weight gain than patients with proven to be clarified. Three-Year efficacy and trials were a three-month period. Registered trademarks of type 2 diabetes. Kohli r, less effect using grade c. Others say researchers searched. Nasuea is based on intestinal gluconeogenesis, the condition. Should be used to maturity onset diabetes in pregnancy in obese patients developed, stick to open label. Check whether metformin because of gut microbiota. Inducing intestinal lumen into the full search resulted in our study heterogeneity. Uptodate it a given to be low dose. Bmi 30 minutes or disadvantage. Possible complications in the risk during august 2007. Nasuea is due to a triple therapy prior authorization. Inducing intestinal gluconeogenesis by reducing inflammation in a group. Figure 1 g/day metformin on sglt1 sensing. Gm effect of an initial combination therapy on weight, congestive heart attacks, advertising and mortality. Peng t, alone within one year comparative study conditions. Beysel s, mccabe m, reviewing reference to reduce tumorigenesis. Recent years, 49, green l, the purpose of this condition existed. Eating and universal healthcare provider about food and tolerability of bedtime nph human study and trulicity helps people with thiazolidinedione. Making major lifestyle changes to manage your doctor right for you can be increased risk of health care providers.
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A man has been airlifted to hospital after a crash involving a pedestrian and a motorcycle in the Highlands.
Emergency crews were called to the scene on the A836 near Invershin at around 11.30am on Wednesday, July 19.
Three ambulances, a trauma team and an air ambulance were dispatched to the scene.
The Scottish Ambulance Service confirmed that one male patient in his 40s was flown to Aberdeen Royal Infirmary. His condition is currently unknown.
Police said the road has been closed in both directions, between Bonar Bridge and Lairg, and local diversions are in place.
A spokesperson for the SAS said: “We received a call today at 11.37am to attend an incident in the Lairg area.
“We dispatched three ambulances, our trauma team and an air ambulance to the scene. We airlifted one male patient in their 40s to Aberdeen Royal Infirmary.”
A Police Scotland spokesperson said: “Around 11.30am on Wednesday, July 19, we were called to a report of a crash involving a motorcycle and a pedestrian on the A836 near Invershin.
“Emergency services are in attendance and the road is currently closed in both directions between Bonar Bridge and Lairg.
“Local diversions are in place and the public are asked to avoid the area at this time.”
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The moment I heard of the closure of Egypt Independent I felt solemn and gloomy. I knew that this was always a possibility, especially with their financial troubles, but this has been the case for a while now, and the suddenness of its shutdown shocked me as well as most of its readers. Suddenly I felt a huge weight being placed on the Daily News Egypt. For better or worse, until the Egypt Independent writers manage to resurrect their paper or come back in a new form as they seem to be planning, the DNE is it now: the last remaining independent English-language source of journalism in Morsi’s Egypt, and one that might not last long either.
It shouldn’t come as a surprise that the DNE is also struggling financially, for this is its second incarnation after being saved by a bunch of investing journalists from complete shutdown last year. It’s for that reason that the DNE writers followed what was happening in Egypt Independent with huge concern. While in other countries the shutdown of a big competitor to a newspaper might be considered a good thing for the ones still in operation, Egypt Independent was not a competitor for Daily News Egypt, for competition exists only when there is a market to compete for, and currently there isn’t really one for an independent Egyptian English daily.
While both have significant readership, judging by their web traffic, this doesn’t translate into income: the average reader would rather read it online for free than purchase it, corporate subscriptions by hotels and tourism-reliant businesses are a thing of the past since tourism is dying, and advertisement in the newspaper or on the portal is almost non-existent due to the state of the economy. Egypt Independent tried to salvage the situation by starting a desperate “subscribe to Egypt Independent” campaign for its individual readers, but it ultimately wasn’t enough since the average reader- you- did not respond to calls for financial support for a service you can get for free. And now that it has shut down, that same reader mourns its loss as a tragedy, which is correct, but not for the reasons he/she cites.
For you, dear reader, it isn’t a tragedy because you will lose out on the excellent reporting and a unique brave voice that stands against all the insanity we live in, even though that’s true. It isn’t a tragedy because some of Egypt’s best writers will go unemployed now, even though that’s true as well, at least until or if they manage to pull off creating a new source of news. It’s a tragedy for you, dear reader, because there were only three local English real newspapers, one of which just shut down, one of which- AlAhram Weekly- is government -owned and has been facing threats of self-censorship or cooption by the government for months now, with its writers continuing to do their work while waiting for the hammer to drop on them at any second, and the last one, the one you are reading now, might not survive for long.
In case the implication of this isn’t clear, let me put it this way: These newspapers do not function only as a news agency, but as a window for the outside world to know what’s really happening in Egypt. They are the only ones telling Egypt’s story for the world, and if they are gone, Egypt and you will be left at the mercy of foreign journalists’ reports, which half of the time are excellent, but the other half are terrible, because they are contingent upon the point of view and ability of the foreign journalist, whose editor doesn’t reside here and will not know bias or ignorance from fact. The shutting-down of those local newspapers is a tragedy because no one will fight for you or tell our story like they will, which is key to provide international pressure on our burgeoning dictatorship, and to not leave you completely at the mercy of the Muslim Brotherhood regime with the world none the wiser. Those newspapers and their work are your cover and protection, they are the people who are fighting and advocating for you by simply reporting the facts of our current insane reality. They are the last remaining bastions of freedom of expression in an increasingly shrinking environment for it. And you will let them wither and die. This is the tragedy.
So, your mission, dear reader, if you choose to accept it, is to not let them wither and die. Your mission is to realize that there are institutions and industries that we need to protect and financially support in order to protect ourselves and preserve our culture and way of life. Your mission as an individual is to subscribe to their services, and if you are a business owner or a marketing manager, to put DNE and the new project by the Egypt Independent crew into your media-buying plans, whether print or digital, even if you don’t personally read it, because you need to protect their role of protecting you. That’s your role, and it doesn’t stop there.
You will also need to support your local arts and culture scene by going to their events and exhibits, even if you don’t end up buying anything. You will need to go to the movies at least once a month and watch a movie, because we need to protect the movie industry, which is also falling apart. The same goes for independent music performances and concerts which you should go to keep the music scene alive; the same goes for hotels in Sharm and Hurghada, who are now offering laughably cheap rates just to survive and not to get bought by Qatari investors who will turn them into Sharia compliant hotels; the same goes for clubs and cabarets, if you are part of the growing alcohol-drinking population. Your mission, duty and civic obligation is to do all of those things, in order to preserve your culture and way of life. The bonus to doing all of this is that these are all fun activities, so it might actually get you out of your funk and depression and provide you more return on your money in enjoyment than going to the same café or restaurant for the umpteenth time. Try it. It’s how we carry on.
Also, please understand, you won’t be doing those things for us. We wouldn’t ask you to sacrifice yourself in these bad economic times for our sake. You will be doing this for yourself and your benefit. So that you wouldn’t wake up one day to similar news that something equally as important and rare as Egypt Independent (or, God forbid, DNE) – but in another field- got shut down due to lack of financial support. If you are feeling helpless in the face of everything that is happening, or you want to help but are not sure how, well, here is the way. We will get through these dark times, I assure you dear reader, but we can’t do it alone and we can’t do it without your help, for we can only perform our roles if you perform yours. It’s time for you to start fighting back as well.


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Open Wednesday-Thursday 10am-6pm, Friday-Saturday 10am-4pm
224 Main St., Lander, WY 82520 | Phone: (307) 332-5772
Stained Glass for Youth, Ages 9 and up
Wednesday December 2 - December 16th, 4:00 - 5:30
Location: 320 Studio
Instructor: Cristina Edwards
Create your own stained glass. Learn to make patterns and shapes, then how to cut glass and solder it together. This class is open to youth who have taken an art class at the LAC previously.

domain: hobby


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A 9th-century Description
This passage is from the geography of Ya’qubi, an Arab Muslim who wrote a history and a geography in Arabic in the 9th century. Here, he describes Qayrawan under the Aghlabids.
Source, pp. 184-5.
The Great Mosque of Qayrawan
The mosque was founded immediately after the conquest, but it reached its current state under the Aghlabids. For the Latin inscription on the Great Mosque of Qayrawan, see here.
Mosque of the Three Doors


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Reviewed on: 3/6/2014 11:43:00 AM
I purchased this wind chime as an anniversary gift for my sister, who likes 'different' off-beat. It was a great hit, even the grandkids loved it. Gilbert's head/neck gentle undulates if there's a breeze or if the chimes are touched. The painted face adds color to the piece and the carved chimes make a soothing noise. I give Gilbert the Gooney Bird wind chime 5 stars!
Reviewed on: 1/10/2013 12:00:00 AM
I bought this as a gift, and it was a real hit.
- LA girl in AZ
Reviewed on: 6/16/2011 12:00:00 AM
It's hanging in my patio. I like its gentle movement. [...]
- Cat lover


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Item #: 1898
Zones: 6a to 8b, at least
Height: 72" tall
Culture: Sun to Light Shade ?
Origin: United States
Pot Size: 3.5" pot (24 fl. oz/0.7 L) ?
Note: This plant is not currently for sale. This is an archive page preserved for informational use.
Click to learn all about the genus Thalictrum and to shop.
Click Add to Wishlist to receive an email if this plant is back in stock.
This is one of my favorite of the meadow rues that I originally acquired from Dick Weaver of WeDu. This NC native makes a splendid 6' tall stately deer-resistant plant for the perennial border, complete with the typical maidenhair fern like foliage. In late spring, the rigidly upright clumps are topped with tiny airy yellow green flowers...a great plant to change textures in the border. Visitors have been begging us to propagate this one, so here it is!

domain: biology


A former Victorian government minister has admitted signing off timesheets that allowed a staff member doing factional work to be paid with taxpayer funds – but Adem Somyurek has denied trying to hide that other employees were performing similar tasks.
Somyurek told the Independent Broad-based Anti-corruption Commission he agreed it was wrong and he had lied when he signed a timesheet approving the payments to a casual staff member he knew was doing work on behalf of the faction at the time.
The commission is investigating whether public resources were misused as part of a widespread branch stacking operation within the moderate faction of the Victorian Labor party branch. Branch stacking is not illegal but is a breach of party rules.
Text messages were shown to the commission that indicated Somyurek was aware that a staffer for the faction, Salazar Youhorn, was required to sort out “member discrepancies” within the Cambodian community at the office of the MP Meng Heang Tak in July 2019.
Ensuring the accuracy of member details was a central part of factional work, the commission has heard.
But on the day the work was being done in Tak’s office, Somyurek signed a time sheet saying Youhorn had instead been doing a “project” in his office. The parliamentary employment timesheet, a copy of which was shown during the hearing on Tuesday, specified “payment must not be claimed for party political activities”.
Somyurek agreed with a suggestion from counsel assisting the commission, Chris Carr SC, that signing the form “was a lie”.
“I’m not going to be cute about it ... yeah, it’s wrong,” Somyurek said.
Soon after, when Carr asked “what about that is not corruption”, Somyurek responded: “Yeah, OK.”
Carr told Somyurek that Ibac had uncovered dozens and dozens of similar timesheets relating to employees signed by Somyurek with a box checked indicating other duties and then specifying “working on project”.
In a separate example involving Youhorn, both Somyurek and Tak paid him for work he supposedly did for each of them on the same day in June 2020, according to two timesheets showed at the hearing.
“There’s obviously a confusion,” Somyurek said. “I can’t see anything sinister in it.”
Another staffer paid by Somyurek, Jacob Cripps, had given evidence to the commission he was specifically told not to show up to Somyurek’s electorate office. Carr said Cripps had given evidence the job “was effectively just a charitable thing that he would be given free money by the taxpayer because he was going through a hard time”.
Cripps was paid after Somyurek signed a timesheet similar to the dozens of others uncovered by Ibac, Carr said.
Somyurek vehemently denied the staffer would have been told not to show up to work or expected not to do any work.
But he said the staffer was given the job because he had been sacked by another faction for switching allegiances to Somyurek’s faction.
Carr also asked Somyurek about Dr Hussein Haraco, who was paid by Somyurek’s office for multiple days while working from home because of Covid-19 restrictions last year, but allegedly did not log on to his computer on those days.
In a phone call intercepted by Ibac in June 2020, Somyurek told Rick Garotti, a factional ally close to Haraco, that he wanted Haraco to be careful, given that Ibac had started its investigation.
He said he wanted Haraco to be careful with “everything”, including logging on, but denied a suggestion from Carr that this was because he was trying to conceal from Ibac the factional work his staffers were doing.
“When Ibac goes into something they’re going to get everything,” Somyurek said on Tuesday. “You can’t hide.”
The Ibac commissioner, Robert Redlich QC, responded: “I wish that was true, Mr Somyurek – you would be surprised how limiting the legislation is.”
Earlier on Tuesday, Somyurek said he “lost all perspective” during a fierce factional battle and should be “condemned” for his behaviour during the period.
But he reiterated that he did not sanction widespread rorting of public funds.
In a recording of a March 2020 conversation played during Somyurek’s evidence, the upper house MP was told by an unidentified Labor staffer working on behalf of the faction that she suspected signatures on some membership forms had been forged.
“Fuck,” Somyurek responds, before asking, “Do people check that much?”
Carr asked whether this indicated Somyurek felt “no compunction” about the forgeries, to which Somyurek agreed, saying the only other possibility was that he thought the Labor staffer was being pedantic.
He said that ultimately he accepted his behaviour during this period had been blinded by a factional battle with the socialist left. “I had lost all perspective, and you can condemn me in the strongest possible terms,” he said.
Somyurek also agreed that earlier in the same discussion he had agreed to pay the membership fees for “Somalis”, in breach of party rules. There was a discussion during the same conversation about who would pay for the fees for members from Indian ethnic backgrounds.
“I’m not trying to say this was anything pure or proper, I’m not trying to justify it,” Somyurek said.
Somyurek, who indicated during his evidence that he was working on a book about his time in politics, was again told multiple times by Carr andRedlich to directly answer questions.
He has made repeated mention of the difference between publicly funded staff performing factional work during part of their rostered hours, as opposed to doing full-time political work, as was uncovered during the Red Shirts scandal.
Carr described this as Somyurek’s “proportionality analysis” to determining what was corrupt, saying it was his position that “as long as it’s only days here or there, there’s no corruption involved”.
Somyurek also repeatedly emphasised that there simply was not enough factional work that needed to be completed that would justify the hiring of people on publicly funded salaries purely for that purpose.
But Somyurek agreed with Redlich that he never told his staff “thou shalt not do factional work during working hours”, partially because he thought it was permitted under laws governing the use of parliamentary staff, and that it was common within politics.
Somyurek’s evidence began on Monday when he accused the Victorian premier, Daniel Andrews, of dismissing his concerns about Labor’s red shirts scandal.
This was a $388,000 scheme involving the misuse of parliamentary allowances to pay Labor’s political campaign staff before the 2014 election.
Somyurek described the red shirts scandal to Ibac as “a gold standard rort”. He said that when he raised his concerns with Andrews, who was then opposition leader, he responded with “words to the effect ... [do] you want to win an election or not, basically”. Somyurek said he had given evidence regarding this meeting with Andrews to a parliamentary committee in 2017 or 2018.
Asked about the claims on Tuesday, Andrews said Labor had made “a number of important rule changes” since the Victorian ombudsman’s investigation into the scheme.
He said the party was “deeply regretful” of the red shirts affair, had already accepted responsibility for it and that he would appear before Ibac if asked to.
Somyurek’s evidence continues on Thursday.


The Chinese owners of Grindr have agreed to sell the gay app by next June after demands from the US government over security and privacy concerns.
Grindr calls itself “the world’s largest social networking app for gay, bi, trans and queer people” and claims more than 3 million daily users worldwide.
The company is based in California but since January last year has been wholly owned by Beijing Kunlun Tech Co.
In March, it emerged that the Committee on Foreign Investment in the United States (CFIUS), a US government body examining national security implications of foreign investment, had deemed Kunlun’s ownership a “national security risk” and demanded Grindr be sold.
In a regulatory filing on Monday, the company said it had reached an agreement with CFIUS prohibiting them from accessing Grindr’s personal data and selling the app by June 30, 2020, Reuters reported.
Kunlun said it would shut down operations in China and would be prohibited from transmitting any sensitive information to any China-based entities.
The company’s ownership of Grindr has led to fears among national security experts and privacy advocates that China could use potentially embarrassing or sensitive private data from the app for espionage purposes.
‘This information can be misused’
Two US Democratic senators Ed Markey and Richard Blumenthal sent a letter to Grindr last year demanding the company explain how user privacy would be protected under its Chinese ownership.
“We’ve previously raised concerns about Grindr’s privacy practices because this application serves uniquely vulnerable groups and collects highly sensitive information, including HIV status and sexual orientation,” the two senators told NBC News last month.
“In the wrong hands, this information can be misused in ways that threaten the safety and well-being of LGBTQ users around the world.
“These concerns are heightened when there is a risk of adversarial foreign actors being privy to the data in question.”
A spokesperson for Grindr told NBC the company “never disclosed any user data (regardless of citizenship) to the Chinese government nor do we intend to.”
UK-based rights group Privacy International said last month that government officials — including US military and intelligence services officers — may be Grindr users.
“The US government is right to be concerned about the possibility of a foreign government gaining access to the most intimate aspects of their lives,” the group said.
“However, it is equally concerning that Grindr users from any country and background are at the mercy of a government, be it the Chinese or the US government.”
Grindr has had to respond to claims of user data privacy issues over the last 18 months, including an alleged encryption flaw that exposed users’ location data even if they’d opted out of sharing it.
Last year, Grindr pledged to stop sharing users’ HIV and location data that it had allegedly not deidentified with two external companies it had contracted, after a backlash.
QN Magazine | For the latest lesbian, gay, bisexual, transgender, intersex and queer (LGBTIQ) news in Australia, visit qnews.com.au. Check out our latest magazines or find us on Facebook, Twitter, Instagram and YouTube.


text:
From Joe Friday & Yeager's Sweet Love, from Krispy Kreme @ Penn and Memorial on Valentine's Day 2013.
Tim McGraw releases his long-awaited album, Two Lanes of Freedom, today (Tuesday). It's his first with his new record label. He says he assembled a group of musicians and camped out in a studio for two weeks. "I wanted it to be a project in which everybody felt like there was a team. And I think that's what this record sounds like."
Today, Tim makes an appearance on The Ellen DeGeneres Show followed by a live concert performance on the U.S.S. Midway in San Diego at 10:30 p.m. ET that will be streamed on Yahoo.com.

domain: celebrity