text:
in the leadership of the university only their
The best place to get cheats, codes, cheat codes, walkthrough, guide, FAQ, unlockables, trophies, and secrets for Grand Theft Auto Online (GTA Online) for PlayStation 4 (PS4).Apr 25, 2018 If you want to tackle GTA Online with some sort of structured progression, this guide.Main article: Grand Theft Auto V Official Score#Grand Theft Auto Online A variety of soundtracks play during missions in GTA Online Some of these play during wanted levels and missions in GTA V , while some are entirely exclusive to jobs in GTA Online.The official home of Rockstar Games. To view this page, please enter your birthday.The easiest is simply living up to the game’s name: Grand Theft Auto, ie: steal cars. If you steal a car (other than the first one you get as your personal ride) you can sell it at the car customisation shops. The better condition it’s in when it arrives the more money you get, but different cars have different values. Typically you can get between 00-00.After weeks of anticipation, the online portion of Grand Theft Auto 5 has finally arrived, allowing players to jump into the world of Los Santos and experience it with their friends through a number of events.Levelling up in Grand Theft Auto Online can be a really tedious, frustrating grind, especially given the availability of uninteresting missions and the noticeable lack of the much-anticipated heists.Dec 17, 2018 Here then, we present the most complete guide to GTA 5 Online you'll find. From cheats and tips in the single-player game to advice for .
Nissan x-trail car repair guide
Welcome to Grand Theft Auto V! Rockstar North's latest masterpiece returns to the fictional state of San Andreas and gives the player their biggest open world yet, with the choice to explore it via a riveting single-player campaign featuring three unique and instantly switchable protagonists or a free-roam online multiplayer experience.The best place to get cheats, codes, cheat codes, walkthrough, guide, FAQ, unlockables, trophies, and secrets for Grand Theft Auto Online (GTA Online) for PlayStation 3 (PS3).'Grand Theft Auto' is a trademark and property of Take Two Interactive Software. GrandTheftAuto.net is an unofficial fan site and is not produced or maintained by Rockstar Games Inc. or Take Two Interactive Software.Grand Theft Auto V Properties Guide explains what buildings you should buy in Los Santos in order to make more money, and what properties you should avoid purchasing if you wish to save the money you have earned so far. Unlike stocks, the Grand Theft Auto 5 Properties are investments that become profitable in time; […].One of the interesting points in introducing Grand Theft Auto online is that it really is something new. It does not have the baggage or the relationships and links to virtually ANY of the previous.Get five times the action with the only official guide to the biggest Grand Theft Auto game ever! BradyGames has teamed up with Rockstar Games to bring you Grand Theft Auto V Signature Series Guide, a comprehensive guide to the biggest and most anticipated.GTA Series Videos is a dedicated fan-channel keeping you up to date with all the latest news, video walkthroughs and official trailers of the most successful video games published by Rockstar.GTA Online is a dynamic and persistent online world for sixteen players. The game will let you and friends team up to tackle missions, activities, and ambient events, as well as competing.
A lot of GTA V and GTA Online players will be seasoned veterans of the PS3 and Xbox 360 versions, but if you're just starting fresh on next-gen (Xbox One and .I think Grand Theft Auto V is an excellent game. To parents wondering what other games it is similar to, other than GTA IV, Just Cause 2 is very similar.Now that GTA Online has finally gone online after October 1, 2013, our Grand Theft Auto 5 Online walkthrough will guide you through the new gameplay with strategy tips for this open world action-adventure game’s online.GTA ONLINE - BEST BEGINNERS GUIDE TO GTA ONLINE (GTA FOR DUMMIES) HOW TO SUPPORT MY CHANNEL: Donations: https://www.paypal.me/Tylarious Merchandise.Jul 24, 2018 Top tips for players starting out in Los Santos' online wilds, plus our list of must-play GTA Online events and activities.There was a tool called GTA V Mod Manager or something that disables all your mods before you launch Online, look into that. A better place.For Grand Theft Auto V on the PlayStation 3, GameFAQs has 12 FAQs (game guides and walkthroughs).Grand Theft Auto Online Hints Tips. by Matt Stone 5 years ago 4 weeks ago. This page contains all our general GTA Online hints and tips. If you specifically want help making money though, check out this guide for all our tips, or this one for our top 3 best ways to make as much money as possible in GTA Online. And if you’re looking for a reliable team for online Heists then check.
Grand Theft Auto Online Game Guide It's time to meet with your friends in Los Santos! This guide to GTA Online answers all the most important questions regarding the first steps.Grand Theft Auto Online is an online multiplayer action-adventure video game developed by Rockstar North and published by Rockstar Games. It was released on 1 October 2013 for PlayStation 3 and Xbox 360, and was released on 18 November 2014 for PlayStation 4 and Xbox One, with a Microsoft Windows version on 14 April.For Grand Theft Auto Online on the PlayStation 3, a GameFAQs message board topic titled "GTA V Vehicle Sales Guide".Grand Theft Auto Online: The Doomsday Heist DLC Trophy Guide After 2 years, Heists have returned to GTA Online. Return to Los Santos in the Doomsday Heist to see if you can save the world from the apocalypse.Grand Theft Auto 5 - Free Guide Bookmark this page, you know you'll.Aug 20, 2018 GTA Online, the multiplayer component of GTA 5 launched October 1, 2013. GTA Online was free to play for everyone who purchased.Grand Theft Auto V Game Guide Welcome to Los Santos! This unofficial guide to Grand Theft Auto V is a complete guide to Los Santos. It will help you experience all of the attractions that the game has to offer and to help you achieve 100% completion.If you want to create, the process is a little more in depth. You are going to go to either a computer or your cellphone. Access the internet in-game and go to FORECLOSURE Maze Bank, which should be the sponsored advertisement in the middle or go to Money And Services, and it should be the top option.
Being dropped in a hostile world is scary. And Grand Theft Auto Online – the recently-launched multiplayer part of open-world action game Grand Theft Auto V – can be very hostile at times.PlaystationTrophies.org PS3 Games Disc-Based PS3 Games G (PS3) Grand Theft Auto V Grand Theft Auto Online: The Doomsday Heist Grand Theft Auto Online: The Doomsday Heist - Roadmap Trophy Guide.1. Genre. Grand Theft Auto V is an action game in which players can travel around one large location taking part in different criminal activities: pulling off heists, with lots of shooting and stealing and driving a variety of cars and other vehicles.Everything you need to beat Grand Theft Auto 5 on PS4, Xbox One, and PC, plus guides to get the most out of your time in GTA Online.This guide contains the best ways to increase each attribute. This will also help you to buff your stats and hopefully, become a better player in Grand Theft Auto Online.Grand Theft Auto GTA 5 Guides Vehicles This is a comprehensive list of all the vehicles available in Grand Theft Auto V. Rockstar has blessed us with some 464 vehicles (including DLC), so we have arranged them alphabetically and into categories which are easily accessible via the menu below.Buy Grand Theft Auto V Limited Edition Strategy Guide (Bradygames Strategy Guides) Limited by Bradygames (ISBN: 8601300415994) from Amazon's Book Store. Everyday low prices and free delivery on eligible orders.View by tag. Exclude. The /r/GTAOnline Mega Guide. Rockstar Server Status. Grand Theft Auto Online is a dynamic and persistent open world for up to 30 players that begins by sharing content and mechanics with Grand Theft Auto V, but continues to expand and evolve with content created by Rockstar and other players.
start highway operating manual
Grand Theft Auto V Signature Series Guide is the most comprehensive to date, GTA 5 Guide from BradyGames. Manual contains all information about.Grand Theft Auto Online is a multiplayer mode of Grand Theft Auto V which considered a stand-alone title by Rockstar Games. It was released on October 1, 2013, 14 days after the single player.deep and engaging. Make sure you read our guides to get the most out of each game. Most of our guides are focused on GTA 5 and Grand Theft Auto Online.Grand Theft Auto: Online - Frequently Asked Questions By Max and 1 collaborators This FAQ will cover the most frequently asked questions about GTA Online, a dynamic and persistent open world for up to 30 players.This Grand Theft Auto Online Warehouses Guide lists all of the warehouses introduced with the Further Adventures in Finance and Felony update as well as price ranges so you can find the cheapest warehouses with the most storage space.Grand Theft Auto V - Grand Theft Auto Online: The Doomsday Heist DLC Trophy Guide By Jiwan01 • Published 21st December 2017 • Updated 8th January.Grand Theft Auto 5 Online Heists Guide. For those that have played Grand Theft Auto 5 single player, you will be familiar with the heists that the characters.GTA BOOM delivers daily news, guides, features and cheat codes for all Grand Theft Auto games, including Grand Theft Auto 5 and GTA Online. Whether you're here for the latest updates on the world of GTA, or just looking for the most complete database of GTA 5 cheats and game guides, you've come to the right place.
This guide to GTA Online answers all the most important questions regarding the first steps in the game. It contains description of character creation along with .Find out the best tips and tricks for unlocking all the achievements for Grand Theft Auto V in the most comprehensive achievement guide on the internet.The Prison Break Guide Introduction. So you made it past the unofficial qualifying round of GTA Heists? Next up you get a taste of 4 player Heist, similar to the previous 2 man heist but with much more complications and complexities.Welcome to PlayStation LifeStyle's trophy guide for Grand Theft Auto Online! The other half of the guide for GTAV's single player can be found.Crime, violence, sex, drugs, and alcohol = not for kids. Read Common Sense Media's Grand Theft Auto V review, age rating, and parents guide.In our second 'Grand Theft Auto Online' Heists guide, we provide a walkthrough, along with tips and tricks, for the game's second heist: The Prison Break.Once you load online for GTA 5 Lester will call you up so you can start up your first heist. The first heist is called the Fleeca Job and it will have you robbing a small bank with one other person. This guide will help you get through the heist on hard so you can earn maximum.The definitive graphics and performance guide for the definitive version of Grand Theft Auto V. Discover the performance and visual impact of each game setting, and learn how you can tweak Rockstar's magnum opus to bolster image quality and frame rates.

domain: game


text:
MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC.
62 CHC patients, 29 patients with CHC and HCC and 19 healthy controls were prospectively enrolled. RNA was extracted from the sera and miR-21 as well as miR-16 levels were analyzed by quantitative real-time PCR; miR-21 levels (normalized by miR-16) were correlated with standard liver parameters, histological grading and staging of CHC. The data show that serum levels of miR-21 were elevated in patients with CHC compared to healthy controls (P<0.001); there was no difference between serum miR-21 in patients with CHC and CHC-associated HCC. Serum miR-21 levels correlated with histological activity index (HAI) in the liver (r = −0.494, P = 0.00002), alanine aminotransferase (ALT) (r = −0.309, P = 0.007), aspartate aminotransferase (r = −0.495, P = 0.000007), bilirubin (r = −0.362, P = 0.002), international normalized ratio (r = −0.338, P = 0.034) and γ-glutamyltransferase (r = −0.244, P = 0.034). Multivariate analysis revealed that ALT and miR-21 serum levels were independently associated with HAI. At a cut-off dCT of 1.96, miR-21 discriminated between minimal and mild-severe necroinflammation (AUC = 0.758) with a sensitivity of 53.3% and a specificity of 95.2%.
Citation: Bihrer V, Waidmann O, Friedrich-Rust M, Forestier N, Susser S, Haupenthal J, et al. (2011) Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma. PLoS ONE 6(10): e26971. https://doi.org/10.1371/journal.pone.0026971
Editor: Hana Algül, Technische Universität München, Germany
Received: May 13, 2011; Accepted: October 7, 2011; Published: October 31, 2011
Copyright: © 2011 Bihrer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: This work was supported by grants from the Else Kröner-Fresenius Foundation, the Deutsche Forschungsgemeinschaft (GRK 1172), and the foundations Dr. Paul und Ursula Klein, Marie Christine Held und Erika Hecker, the Scolari Foundation and the Heinrich und Erna Schaufler Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Hepatocellular carcinoma (HCC) is one of the most common solid tumors, rated third in mortality worldwide . Most HCCs develop in fibrotic or already cirrhotic liver which are a result of chronic infection with hepatitis B (HBV) or hepatitis C virus (HCV) . Currently, there are no biomarkers for the early detection of HCC, and most patients with HCC are diagnosed at advanced stages, which are associated with poor prognosis and low survival rates due to a lack of curative treatment options. α-Fetoprotein (AFP) has mainly been used for diagnosis of HCC; however, its sensitivity and specificity are not satisfying .
MicroRNAs (miRNAs) are small noncoding RNAs (18–24 nucleotides) that interact with their target mRNAs to inhibit translation by promoting mRNA degradation or to block translation by binding to complementary sequences in the 3′-untranslated region of mRNAs . An integral role of miRNAs in cancer pathogenesis has begun to emerge. MiRNA expression profiling reveals characteristic signatures for many tumor types . Importantly, miRNAs have also been detected in human serum and plasma, where they are remarkably stable , raising the possibility that unique miRNA patterns in serum and plasma might be used as non-invasive disease markers. In support of this, differences have been found between miRNA patterns in serum or plasma of patients with a number of malignancies and healthy controls .
Analysis of the miRNA signatures of a large number of tumor samples, including lung, breast, stomach, prostate, colon, and pancreatic cancer and their respective normal adjacent tissue, revealed that miR-21 is the only miRNA upregulated in all these tumors , including HCC –. Considerable evidence supports the hypothesis that miR-21 is a central oncomiR . miR-21 levels are also significantly elevated in serum/plasma of patients with diffuse large B-cell lymphoma, ovarian cancer, prostate cancer or breast cancer –, rendering it an interesting candidate as serum/plasma marker for malignancies.
miR-21 has also been linked to fibrosis in the lung , heart  and liver . In the liver the level of miR-21 correlates with hepatic fibrosis . A close link between miR-21 and hepatic fibrosis is supported by the findings that transforming growth factor β (TGF-β), a critical mediator of hepatic fibrogenesis , , promotes the expression of miR-21 , and that miR-21 decreases the expression of SMAD7 , a negative regulator of TGF-β signalling . A recent study has reported that circulating miR-21 might be useful as biomarker for HCC .
Alterations of the miR-21 concentration in serum or plasma of patients with HCV-induced chronic hepatitis C (CHC) have not yet been reported. Hypothesizing that miR-21 serum levels might be related to either malignancy, i. e. HCC, or liver fibrosis/cirrhosis or both, we here investigated the relation between miR-21 serum levels and clinical parameters in patients with CHC, CHC plus HCC, and healthy volunteers.
Patients with CHC (n = 62) as well as CHC plus HCC (n = 29), who had undergone liver biopsy for staging and grading of CHC at the Frankfurt University hospital, were prospectively enrolled in the present cohort study. An independent cohort of 47 CHC patients was used for validation. Inclusion criteria were detectable anti-HCV antibodies and HCV-RNA for at least six months. Exclusion criteria were decompensated liver disease, malignancy other than HCC, organ transplantation, co-infection with HIV or HBV, immunosuppression and autoimmune co-morbidities. Patients' characteristics are summarized in Table 1 and 2. The Ethics Committee of the University Hospital Frankfurt approved this study. From all enrolled patients and healthy subjects written informed consent was obtained according to the Declaration of Helsinki.
Hematoxylin-eosin stained sections of formalin-fixed, paraffin-embedded liver biopsies were reviewed by experienced pathologists for evaluation of fibrosis stages (F0 = no fibrosis - F6 = cirrhosis) and the histologic activity index (HAI) in the liver according to the Ishak criteria .
10 mL of peripheral blood was collected at the time of liver biopsy (serum tubes, Sarstedt, Nümbrecht, Germany). Cellular components were removed by two consecutive centrifugation steps (1500 g for 10 min at 4°C and 2000 g for 3 min at 4°C, respectively). Sera were stored at −80°C until use.
Detection of miRNAs by Quantitative Real-time Reverse-Transcription (RT)-PCR
RNA was isolated from 500 µL serum using Tri®ReagentLS (Sigma-Aldrich, St. Louis, MO), chloroform and the mirVana™ RNA isolation kit (Ambion-ABI, Austin, TX). Total RNA was eluted in 100 µL and stored at −20°C. 5 µL of RNA was reverse transcribed with the TaqMan® miRNA reverse transcription kit and the TaqMan® miRNA assay specific RT primers for miR-21 or miR-16 according to the instructions of the manufacturer (ABI). Real-time PCR was performed with 3 µL of each cDNA on a StepOne™Plus Real-Time PCR System (ABI) in duplicates. The cycle treshold (CT) defines the number of PCR cycles required for the fluorescent signal to cross the threshold.
Data were analyzed using the BiAS software for windows (version 9.07). Statistical significance for correlations was determined using Spearman's nonparametric rank test. Differences between two groups were evaluated using the Wilcoxon-Mann-Whitney-U test. P values<0.05 were considered to be significant. For the multivariate analysis a logistic regression with Wald's test was used to evaluate whether minimal (HAIA+B+C≤3) vs. mild to severe (HAIA+B+C>3) necroinflammation correlated independently with the parameters. The criterion for elimination in the stepwise model was P>0.1.
miR-21 as well as miR-16, a miRNA found at constant levels in sera from various diseases, including chronic hepatitis B , , were quantified by real-time RT-PCR in sera from patients with CHC, CHC plus HCC and healthy controls. The mean CT values (95% confidence interval (CI)) of miR-16 were 25.1 (24.5–25.6) in healthy donors and 25.2 (24.9–25.5), 25.0 (24.4–25.6) and 25.1 (24.2–26.0) in patients with CHC, in patients with CHC and normal alanine aminotransferase (ALT) and CHC plus HCC, respectively, showing that miR-16 in serum can be used as an internal control to normalize sampling variations in RT-qPCR in our collective of sera. The dCT (CT-miR-21 - CT-miR-16) value negatively correlates with the serum level of miR-21. dCT of miR-21 was higher in sera from healthy controls (3.4, CI: 3.0–3.8) than in sera from patients with CHC and elevated serum ALT activity (2.2, CI: 2.0–2.4) (P<0.001, Fig. 1A), a parameter reflecting liver damage. In contrast, the dCT value for miR-21 in sera from CHC patients with normal ALT values (3.0, CI: 2.7–3.3, P<0.05) only slightly differed from that of the control sera (Fig. 1A). ROC curve analysis was performed on the data from all CHC patients (without HCC) and controls. The area under the ROC curve (AUC) was 0.826 (CI: 0.711–0.942) (Fig. 1B), with a P value of 0.000018. The optimal cut-off value for miR-21 (normalized to miR-16) to discriminate between healthy controls and CHC patients was 3.16, with a sensitivity of 87.1%, specificity of 73.7% and false classification rate of 19.6%.
(A), dCT values of miR-21 of sera from healthy control individuals (n = 19), patients with CHC and elevated serum ALT levels (n = 44) and CHC patients with normal serum ALT levels (n = 18). Boxes represent range, median and quartiles of the number of threshold cycles (CT) required to detect miR-21 by real-time RT-qPCR normalized to CT of miR-16. Differences were calculated with Wilcoxon-Mann-Whitney-U-test. *P<.05, ***P<.001, compared with the healthy control group. +++P<.001 between CHC patients with normal or elevated ALT. (B), ROC curve analysis of serum miR-21 concentration for discriminating CHC patients and healthy controls. (C), dCT values of CHC patients with elevated ALT and HAI≥5 (n = 31) and patients with CHC and HCC (n = 29) showing no significant difference in miR-21 levels (Wilcoxon-Mann-Whitney-U-test: P>.3) between both groups, n. s. = not significant. (D) Relationship between serum miR-21 levels and the serum HCV RNA in patients with CHC. The relation is not significant (P = .29).
There was no significant difference between the dCT values of miR-21 in sera from patients with CHC plus HCC and those with CHC and matched HAI (Fig. 1C). Moreover, we investigated if there is a relation between the serum levels of miR-21 and serum HCV RNA. However, there was no correlation between the serum miR-21 and HCV RNA level (P = 0.29) (Fig. 1D).
To investigate the relation between the serum miR-21 level and standard liver function parameters, we correlated the relationship between the levels of miR-21 with the serum albumin concentration, international normalized ratio (INR), bilirubin and γ-glutamyl-transferase (γ-GT). There were positive correlations between the serum level of miR-21 and INR (r = −0.362, P = 0.002) (Fig. 2A), serum bilirubin concentration (r = −0.338, P = 0.003) (Fig. 2B) and γ-GT activity (r = −0.244, P = 0.034) (Fig. 2C). The correlation between the serum albumin concentration and the serum miR-21 level did not reach statistical significance (P = 0.0893) (Fig. 2D).
To examine if the levels of miR-21 in sera from patients with CHC as well as CHC plus HCC reflects necroinflammatory activity in the liver rather than HCC, we correlated the dCT values of serum miR-21 with ALT, aspartate aminotransferase (AST) as well as with the histologic activity index (HAI) score in the liver. The dCT value of miR-21 in the sera negatively correlated with serum levels of ALT (r = −0.309, P = 0.007) (Fig. 3A) and AST (r = −0.495, P = 0.000007) (Fig. 3B), i. e. the serum level of miR-21 positively correlated with ALT and AST activities. The dCT values of serum miR-21 also strongly correlated with the HAI score (r = −0.494, P = 0.00002) (Fig. 4A).
Points represent dCT values for miR-21 normalized to miR-16.
; (B), ROC curve analysis of serum miR-21 concentration for discriminating patients with minimal (HAIA+B+C≤3) vs. moderate to severe necroinflammatory activity (HAIA+B+C>3) using dCT of miR-21; (C), relationship between serum miR-21 and fibrosis index in patients with CHC.
In order to confirm the correlation between serum miR-21 levels and hepatic necroinflammation, we examined an independent validation cohort of 47 CHC patients. As illustrated in Fig. 5, the serum levels of miR-21 correlated with ALT (r = −0.352, P = 0.015588) and AST (r = −0.375, P = 0.010614). Histological classification according to Ishak was not available for these patients.
To investigate if the serum miR-21 level might be useful to discriminate patients with minimal (HAIA+B+C≤3) and mild to severe necroinflammation in the liver (HAIA+B+C>3), we performed multivariate analysis to examine the independency of the different parameters. Multivariate analysis revealed that only the correlations between HAI and serum ALT as well as miR-21 were independent (Table 3).
To test the suitability of miR-21 to discriminate minimal from mild to severe necroinflammation, we performed a ROC curve analysis on the data. The AUC was 0.758 (P = 0.00021) (Fig. 4B). At the optimal cut-off value of 1.96, the sensitivity was 53.3%, the specificity 95.2% and false classification rate was 25.7%.
To investigate if the serum miR-21 level might be related to liver fibrosis, we correlated the dCT values of serum miR-21 and the histological fibrosis index in the liver. There was a trend towards a negative correlation between the Ishak fibrosis index and the dCT of miR-21 in the sera from CHC patients (r = −0.243, P = 0.054) (Fig. 4C).
Compared to the corresponding normal tissue miR-21 has been shown to be consistently elevated in malignant tumors, including HCC , . Importantly, this miRNA is not only upregulated in association with oncogenesis, but can act as oncogenic miRNA . It inhibits targets related to apoptosis and to transformation such as programmed cell death 4 and phosphatase and tensin homolog , . miR-21 is also elevated in sera from patients with prostate carcinoma , mamma carcinoma ,  and HBV-associated HCC , raising the possibility that it may serve as serum marker for malignant diseases. A recent study has suggested that circulating miR-21 is a marker for HCC . However, that study did not allow differentiation between patients with liver cirrhosis and HCC. We report here that the level of miR-21 in sera from patients with CHC-associated HCC was elevated compared to healthy controls. However, we also detected increased levels of miR-21 in sera from patients with CHC without HCC. Indeed, sera from patients with matched HAI score and CHC showed similar miR-21 levels than sera from patients with CHC-associated HCC. Thus, the elevation of serum miR-21 levels in our CHC patients appears to be mainly associated with chronic hepatitis rather than HCC. The link between the elevated levels of serum miR-21 and CHC is supported by our finding that miR-21 serum levels strongly correlated with ALT and AST activities in two independent cohorts of CHC patients, parameters of ongoing liver damage. Concordantly, elevated serum levels of miR-21 were found only in CHC patients showing elevated ALT levels, whereas sera from CHC patients with normal ALT levels also contain normal miR-21 serum concentrations. Moreover, the serum miR-21 levels also strongly correlated with the HAI score, supporting the suggestion that the serum miR-21 level is related to necroinflammatory activity in the liver in patients with CHC. Multivariate analysis of the data from patients with minimal or mild to severe necroinflammation in the liver revealed that only ALT and miR-21 correlated independently with necroinflammation in the liver. Thus, the serum miR-21 concentration might be a useful parameter to differentiate patients with minimal vs. mild to severe necroinflammation in the liver which is of clinical relevance.
Mechanistically, miR-21 may leak from damaged cells similar to ALT and AST, or may be actively exported from altered tissues as a mechanism of adaptation to alterations of the state of a cell . Recent evidence suggests that the majority of miRNAs in serum or plasma, including miR-21, is complexed to proteins such as Ago2, thereby explaining the high stability of endogenous miRNAs in serum/plasma .
There is clear evidence for a close relation between miR-21 and hepatic fibrosis. Thus, the hepatic level of miR-21 appears to correlate with the stage of liver fibrosis . miR-21 is strongly expressed in tumor cells, but also in tumor-associated fibroblasts . In the present study the miR-21 concentration in serum showed a strong correlation with the HAI score, whereas the relation between the serum miR-21 level and the fibrosis score did not reach statistical significance, which is in agreement with a study published during revision of the present manuscript . This suggests that serum miR-21 levels are related to liver damage activity rather than to liver fibrosis in patients with CHC.
There was no correlation between the concentrations of miR-21 and HCV RNA in serum. This can be reconciled with the lack of correlation of HCV serum level and disease activity in patients with CHC .
Similar to the data of the present study, it has recently been reported that sera from HBV-induced chronic hepatitis contain elevated levels of miR-21 in comparison to healthy controls . However, in another study with patients suffering from HBV-induced chronic hepatitis, no elevation of serum miR-21 levels was found despite strongly elevated ALT and HAI scores in these patients , leaving the role of serum miR-21 in HBV-induced chronic hepatitis unclear.
Recent studies reported differential levels of miR-16 in sera from patients with HCC, chronic hepatitis of different etiology and healthy controls , . In the present study, however, we did not find differences in the levels of miR-16 between sera from patients with CHC, CHC-associated HCC and healthy controls. Our data are in agreement with several other studies reporting invariant levels of miR-16 in sera from patients with several diseases , including HBV-induced chronic hepatitis and HCC, and healthy controls , , prompting utilization of this miRNA for normalization . The reasons for the different findings between the studies remain elusive.
Our recent data show that serum levels of the liver-specific miR-122 also correlate with the HAI score as well as serum AST and ALT levels . Thus, miR-21 and miR-122 may originate from the inflamed liver. However, miR-21 and miR-122 differ in that miR-21, but not miR-122, correlates with bilirubin, INR and γ-GT in CHC patients. Obviously, the serum levels of miR-21 and miR-122 reflect overlapping, but not identical disease parameters in CHC patients. This might be related to the different expression pattern of miR-21 and miR-122, miR-122 being highly selective for the liver, whereas miR-21 shows significant expression in other cells and tissues. For instance, miR-21 is strongly expressed in lymphocytes . Thus, release of miR-21 from several different cell types may contribute to the elevation of the serum miR-21 level in patients with chronic hepatitis. A drawback of the broader expression pattern of miR-21 compared to miR-122 is that co-morbidities are more likely to reduce the diagnostic power of the serum miR-21 level than that of miR-122.
The identification of non-invasive biomarkers for the diagnosis of diseases has become a rapidly growing area of clinical research . The discovery of miRNAs circulating in the peripheral blood has opened new directions of research to identify new non-invasive ways of diagnosis of disease. In summary, the data of the present study indicate that the level of serum miR-21 is suitable to detect necroinflammatory activity in the liver and not the presence of HCC. It appears likely that serum miRNAs can provide information on different aspects of chronic hepatitis not available from the presently used routine parameters of liver damage.
We thank Ursula Karey, Dany Perner and Yolanda Martinez for excellent technical assistance.
Conceived and designed the experiments: A. Piiper BK OW. Performed the experiments: VB JH. Analyzed the data: OW BK JP-O SZ A. Polta HHR. Contributed reagents/materials/analysis tools: MF-R NF MW YS JT CS MvW SS OW BK. Wrote the paper: A. Piiper.
- 1. El-Serag HB, Marrero JA, Rudolph L, Reddy KR (2008) Diagnosis and treatment of hepatocellular carcinoma. Gastroenterology 134: 1752–1763.
- 2. Zinkin NT, Grall F, Bhaskar K, Otu HH, Spentzos D, et al. (2008) Serum proteomics and biomarkers in hepatocellular carcinoma and chronic liver disease. Clin Cancer Res 14: 470–477.
- 3. Du T, Zamore PD (2005) microPrimer: the biogenesis and function of microRNA. Development 132: 4645–4652.
- 4. Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, et al. (2006) A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 103: 2257–2261.
- 5. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, et al. (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105: 10513–10518.
- 6. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, et al. (2007) MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133: 647–658.
- 7. Varnholt H (2008) The role of microRNAs in primary liver cancer. Ann Hepatol 7: 104–113.
- 8. Ladeiro Y, Couchy G, Balabaud C, Bioulac-Sage P, Pelletier L, et al. (2008) MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology 47: 1955–1963.
- 9. Marquez RT, Bandyopadhyay S, Wendlandt EB, Keck K, Hoffer BA, et al. (2010) Correlation between microRNA expression levels and clinical parameters associated with chronic hepatitis C viral infection in humans. Lab Invest 90: 1727–1736.
- 10. Medina PP, Nolde M, Slack FJ (2010) OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 467: 86–90.
- 11. Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, et al. (2008) Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol 141: 672–675.
- 12. Zhang HL, Yang LF, Zhu Y, Yao XD, Zhang SL, et al. (2011) Serum miRNA-21: Elevated levels in patients with metastatic hormone-refractory prostate cancer and potential predictive factor for the efficacy of docetaxel-based chemotherapy. Prostate 71: 326–331.
- 13. Asaga S, Kuo C, Nguyen T, Terpenning M, Giuliano AE, et al. (2011) Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer. Clin Chem 57: 84–91.
- 14. Liu G, Friggeri A, Yang Y, Milosevic J, Ding Q, et al. (2010) miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 207: 1589–1597.
- 15. Thum T, Gross C, Fiedler J, Fischer T, Kissler S, et al. (2008) MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456: 980–984.
- 16. Matsuzaki K, Murata M, Yoshida K, Sekimoto G, Uemura Y, et al. (2007) Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma. Hepatology 46: 48–57.
- 17. Dooley S, Hamzavi J, Ciuclan L, Godoy P, Ilkavets I, et al. (2008) Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage. Gastroenterology 135: 642–659.
- 18. Davis BN, Hilyard AC, Lagna G, Hata A (2008) SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454: 56–61.
- 19. Tomimaru Y, Eguchi H, Nagano H, Wada H, Kobayashi S, et al. (2011) Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma. J Hepatol.
- 20. Ishak K, Baptista A, Bianchi L, Callea F, Groote JD, et al. (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22: 696–699.
- 21. Iliopoulos D, Jaeger SA, Hirsch HA, Bulyk ML, Struhl K (2010) STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell 39: 493–506.
- 22. Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, et al. (2008) Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J Biol Chem 283: 1026–1033.
- 23. Xu J, Wu C, Che X, Wang L, Yu D, et al. (2011) Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis. Mol Carcinog 50: 136–142.
- 24. Wang K, Zhang S, Weber J, Baxter D, Galas DJ (2010) Export of microRNAs and microRNA-protective protein by mammalian cells. Nucl Acids Res 38: 7248–7259.
- 25. Arroyo JD, Chevilleta JR, Kroha EM, Rufa IK, Colin C, et al. (2011) Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA 108: 5003–5008.
- 26. Yamamichi N, Shimomura R, Inada K, Sakurai K, Haraguchi T, et al. (2009) Locked nucleic acid in situ hybridization analysis of miR-21 expression during colorectal cancer development. Clin Cancer Res 15: 4009–4016.
- 27. Cermelli S, Ruggieri A, Marrero JA, Ioannou GN, Beretta L (2011) Circulating MicroRNAs in Patients with Chronic Hepatitis C and Non-Alcoholic Fatty Liver Disease. PLoS One 6: e23937.
- 28. Poynard T, Bedossa P, Opolon P (1997) Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet 349: 825–832.
- 29. Zhang Y, Jia Y, Zheng R, Guo Y, Wang Y, et al. (2010) Plasma microRNA-122 as a biomarker for viral-, alcohol-, and chemical-related hepatic diseases. Clin Chem 56: 1830–1838.
- 30. Qu KZ, Zhang K, Li H, Afdhal NH, Albitar M (2011) Circulating microRNAs as biomarkers for hepatocellular carcinoma. J Clin Gastroenterol 45: 355–360.
- 31. Bihrer V, Friedrich-Rust M, Kronenberger B, Forestier N, Haupenthal J, et al. (2011) Serum miR-122 as a biomarker of necroinflammation in patients with chronic hepatitis C virus infection. Am J Gastroenterol 106: 1663–1669.
- 32. Wu H, Neilson JR, Kumar P, Manocha M, Shankar P, et al. (2007) miRNA profiling of naïve, effector and memory CD8 T cells. PLoS One 2: e1020.
- 33. Zen K, Zhang CY (2010) Circulating MicroRNAs: a novel class of biomarkers to diagnose and monitor human cancers. Med Res Rev. [Epub ahead of print].

domain: medical


text:
Get Quality Accounting Services In Brooklyn NY | NASIR FAIZI CPA PLLC
Are you looking for professional accounting services in Brooklyn NY? Then you must go with one of the quality accounting service providers in Brooklyn, NY. Nasir faizi CPA PLLC is an excellent service provider in Brooklyn, NY. Our main goal is to provide the best accounting services to our clients so, that they can set the goals for their business growth or achieve new opportunities. For more information, visit our website or call us at (718) 510-6771.

domain: finance


Based on an actual outdoor tests conducted over a 10-year period it was proven that durability of a safety helmet is largely influenced by the material. The statement that durability of safety helmets of duroplastic materials will only be limited due to mechanical damage, has been proven wrong. Safety helmets manufactured among others of UV-stabilised polyethylene should therefore be replaced after four years, those of phenolic resin fabric after eight years and safety helmets of glass fibre reinforced polyester or polycarbonate after ten years (maximum time span).
VOSS helmets of polyethylene have fulfilled the artificial ageing as per Appendix B of EN 397, and after up to five years are still complying with the required standards.
This is proof of the high quality of our safety helmets. However, after a hard crack the safety helmet may no longer be used.


Perception's Plug & Play EZY Fit Wiring Harness is the ideal solution for easy fitment of your driving lights. The supplied H4 Adaptor trigger your driving lights from your high beam without cutting or soldering any wiring. Simply unplug your H4 connector at the back of your head lights bulb, plug in our adapter and you're done! Driving lights will only trigger from high beam, and the switch will act only as an isolator.
Contains everything you need to get your lights connected: ON/OFF Switch, 40A Relay, 30A Fuse, ribbed cable protectors, heat shrink wrapped relay.
Featuring a total 4.8 meters of wiring (full stretched out)
2.4m of cabling from Relay to Switch
2.0m of cabling from Driving Light connector to Relay
2.0m from H4 Adapter to Relay
Total cable length 6.4m
12vDC 30A Rated Fuse Kit
12vDC 40A Switching Relay
Push Button ON/OFF Switch
UV Rated Insulation
1 x DT connector to connect 1 Light Bar
H4 is the most common wiring connects found in most popular makes and models. In the event that your car does not use H4, this wiring harness can still be used to connect to high beam however you will need to cut and join the trigger wires.


The Aero Wind Vest | AeroForce | Fe226
Say goodbye to bulky windbreakers stealing your thunder on race day! The Aero Wind Vest is here to save the day with its ultra-lightweight and lightning-fast AeroForce fabric, tailored fit, and water-repellent powers! Put it on and unleash the AeroForce within! (It won’t slow ya down, promise.)
The Fe226 Aero Wind Vest is probably the fastest solution on earth. It is made from the super fast and ultra fast drying AeroForce fabrics, fits like a second skin, is water repellent and won't slow you down as other vests do.
Choose the AeroForce Aero Wind Vest and set a PB! Apart from roomy back pockets, bonded edges (minimum chafing), laser cut cooling holes and reflective tape, the Aero Wind Vest features our patented AeroForce fabric offering you 4-way dynamic stretch for compression yet effortless movement, 4-6 times faster drying, +35% weight-saving and cooling effect (ColdBlack®).
Our products are carefully crafted in European factories that uphold high social and environmental standards. We are committed to using top-quality, locally sourced materials and producing in limited runs. For more insight into our production approach, please refer to our product dogmas. While our prices may be higher than those of more well-known brands, keep in mind the significant value and benefits that come with our garments when considering cost.
By rinsing under running water and letting it air dry after each use, you can reduce the need for washing to 3-8 times, resulting in less bacterial growth and ultimately extending the lifespan of your clothing. This not only saves you money in the long run, but is also better for the environment. We understand this may require an adjustment, but we assure you that it is well worth it.
Train more, wash less!
Fe226 prides itself on exceptional quality, carefully selecting and crafting premium fabrics with expertise. With an ergonomic fit designed by and for athletes, our products provide top-notch performance. These innovative items require minimal washing thanks to their antibacterial and durable properties, making them environmentally friendly. Our focus on essential simplicity and subtle details, along with classic designs, ensure longevity and style. Sourced from ethical and sustainable partners, our European-made fabrics and productions exceed industry standards.


text:
[This post has already been read 1289 times!]
How do we consistently get the employees to say “I love my job, I trust my leader and I’m ready to rock today“?
If you’ve tried a variety of incentives but are still seeing the negative side effects of low motivation, you’re not alone. Sometimes even the best managers have to think outside the box to find creative and reliable ways to motivate their employees.
Since not all businesses can afford to hand out regular bonuses, you need to look for other ways to help employees stay motivated and productive.
Empowerment and motivation happen when people solve their own problems and create their own aspirations and expectations. That’s why the outcome motivation tool is powerful from the first step. It helps our employees to find out what they really want and how they know when they’ve got it. It generates clarity and insights. Helping our people focus on the outcome they want to create, not the problems in the way, activates their reward (pleasure) network.
If you want to know how to motivate your employees and get positive employee engagement, you have to make them feel passionate to go to work every day and want to spend time with you and their colleagues.
Motivating your employees does not have to be a challenge anymore. Try the course:
Lucubrate crash course is a rapid and intense course of study. This crash course is about motivating the employees. It is a short course in which you are taught basic facts and skills.
Lucubrate crash course is built on the model of 3x3x3. This means that one crash course has three lessons. Each lesson has three topics. Each Topic has three questions for reflection.
Lucubrate Magazine November 2019
The picture on the top of this article: Conceptual symbol of cooperation diverse hands making a circle. Photo: Adobe Stock

domain: psychology


Modified Polyamine Ceramic Epoxy
A 100% solids, abrasion-resistant lining specifically designed for wastewater immersion and fume environments and exposure to corrosive soils. Provides low permeation to H2S gas, protects against MIC and provides chemical resistance to steel, ductile iron pipe and fittings for severe wastewater or buried exposures. A coal-tar free, resin-rich formulation with low pigment volume concentration (PVC) for maximum performance.
Contains 20% ceramic microspheres for increased abrasion resistance. Compatible with high-velocity jet sewer cleaning (hydrocleaning) with 0-degree tips (Reference Technical Bulletin No. 11-86).
Meets the performance requirements of AWWA C 210 (not for potable water contact).
Product Data Sheets
Safety Data SheetsEmail this product
- 5024 Sewer Pipe Green
View Available Colors
View available colors in our Color Tool; you can also select and request color swatches.
Volatile Organic Compounds
EPA Method 24: 0.19 lbs/gallon (23 grams/litre)
Self-priming, Series 61 or N140. Note: Self-priming or Series 61 is recommended for use in mesophilic anaerobic digesters and other severe exposures. Note: Series 431 must be applied to the Series 61 or N140 within 7 days. Scarify the surface with fine abrasive before topcoating if this maximum recoat window is exceeded. Contact your Tnemec representative for more information.
|Temperature||Set to Touch||Max. Recoat||To Place in Service|
|90°F (32°C)||1-2 hours||7 days||24 hours|
|75°F (24°C)||2-3 hours||7 days||2 days|
|55°F (13°C)||8-9 hours||7 days||3 days|
Note: If more than 7 days have elapsed between coats, the Series 431 coated surface must be mechanically abraded (scarified) before topcoating. Curing time will vary with surface temperature, air movement, humidity and film thickness.
0.00 lbs/gal solids
1,604 mil sq ft/gal (39.4 m²/L at 25 microns). See APPLICATION section for coverage rates.
Carbon Steel: 30.0 to 50.0 mils (760 to 1270 microns) in one or more coats.
Ductile Iron: 40 mils (1015 microns) (nominal) in one or more coats.
Note: Number of coats and thickness requirements will vary with substrate, application method and exposure. Use Series 44-721 to increase film build. Amounts vary by kit size, refer to the Series 44-721 product data sheet. Contact your Tnemec representative for more information.
Number of Components
Two: Part A (amine) and Part B (epoxy)
Still have questions? Request the information you’re looking for:Request Info
How to Purchase
Tnemec coatings are sold through a select network of local independent sales representatives who can help you find the best product for your needs. Find a rep


School districts are getting the word out on a new state vaccination rule that, if not followed, would bar Pennsylvania children from classes more quickly.
Under new regulations, parents will have to make sure their children have all required shots within the first five days of school. Before, they had eight months to get their children in compliance.
The Pennsylvania Department of Health issued the timetable change along with new rules requiring a fourth dose of the polio vaccine and a second dose of the rubella vaccine.
For children who are not vaccinated within five days, parents must provide a medical plan explaining when they will be. If they don't, the child will be barred from school.
The changes mostly impact incoming kindergarteners, but seventh- and 12th-grade will also see new requirements. Parents will still be able to opt out of vaccinations for moral, medical and religious reasons.
The changes are being implemented to ensure more accurate reporting of who is vaccinated to the national Centers for Disease Control and Prevention and to reduce the potential for outbreaks, according to the state health department.
School nurses across the state have been working to get the word out to parents. Southern Lehigh, for example, posted a reminder about the changes on its website and sent information home with children.
"We certainly do not want to exclude any student, so we are committed to work with all families to support them in ensuring requirements are met," the district said on its website. "Please work with your child's physicians to ensure all immunizations have been given."
In Bethlehem Area, nurses have been working long hours combing through students' data to determine who still needs shots, said Kathy Halkins, supervisor of health services.
For seventh- and 12th-graders, a child's birthday and last shot will used to determine if he or she needs a new vaccine.
High school seniors, for example, will need a second meningococcal conjugate vaccine (for meningitis) under the new regulations, unless their first one was given on or after their 16th birthday, Harris said.
For seventh-graders, they'll need another dose of tetanus, diphtheria, acellular pertussis (Tdap) and meningococcal conjugate vaccine by the first day.
Bethlehem Area schools are sending flyers home with parents about the changes, Halkins said. The back-to-school newsletter will be delivered to parents in early August, rather than later in the month, to remind parents about the vaccines.
Additionally, the school district is teaming up with the Bethlehem Health Bureau for a health clinic on May 23 and Aug. 31 for uninsured and underinsured children. There, the district will be giving parents additional information on how to get their children the vaccines they need.
"We don't want to exclude a kid because they don't have enough shots," she said. "We're really working hard to make sure kids don't miss school."


President Donald Trump declared a reprieve today for Rod Rosenstein, saying he has no plans to fire his deputy attorney general whose future has been the source of intense speculation for two weeks.
The stop-and-frisk policy in New York City is a practice of temporarily detaining and questioning and sometimes searching people for weapons or contraband. The crime spree is a bad blight on that city and we'll do everything possible to get it done.
What Trump failed to note, and what The Associated Press reported, is that Chicago's homicide rate and number of shooting victims are down compared to this time previous year. He said returning to an era of rampant and unrestricted stop-and-frisk, the kind that was ruled unconstitutional in New York City, would be "antithetical" to the "strong, pro-active, professional police department" the city is building.
Trump said in 2016, a law enforcement officer was assaulted on an average of every nine minutes in the United States.
"I think we'll be treated very fairly".
Chicago police said last week that there have been 102 fewer homicides and almost 500 fewer shooting victims in the city this year, compared to the first nine months of 2017.
Kelly was present for Monday's conversation between Rosenstein and Trump, the White House said, as was Rosenstein's top deputy at the Justice Department, Ed O'Callaghan.
Boarding Marine One Monday morning, the President told members of the press that he and Rosenstein will be "talking on the plane" and noted that they "actually have a very good relationship".
Conor McGregor Has Already Called Dana White Asking For Rematch
McGregor (21-4) suffered a fourth-round submission loss to Nurmagomedov (27-0) at UFC 229 last weekend in Las Vegas . Tukhugov was a participant in Saturday night's fracas.
Windows 10 update suspended after it started deleting people's files
On Saturday Microsoft decided that the tide of consumer reports complaining about the latest Windows Update was high enough to pause the software rollout .
Storm Michael Expected to Hit Florida as a Hurricane Midweek
The Hurricane Center also issued a Storm Surge Watch from Navarre, in the Florida Panhandle, to Anna Maria Island. This is a map showing the forecast cone for Hurricane Michael , which strengthened from a tropical storm.
In a statement to the Chicago Sun-Times, Chicago Mayor Rahm Emanuel sought to shoot down the president's idea as out of touch with the city's real needs. This year, with nearly three months to go, 419 people were murdered in Chicago, according to the Chicago Tribune's homicide database.
Patrol Officer Mark Dallas of the Dixon, Illinois, Police Department stopped an active shooter in a high school before the suspect could harm any of the students.
Emanuel, a former White House chief of staff to President Barack Obama who became mayor in 2011, said on September 4 he would not seek re-election next year.
Translation: increasing street stops, which many blacks view as mere harassment, would harm police relations the city's working to rebuild in the wake of the Laquan McDonald murder and Jason Van Dyke's conviction.
Johnson blamed gang violence, soft punishment for offenders, and an epidemic of illegal guns. McDonald, 17, was killed while armed with a knife.
'Politicians who spread this unsafe anti-police sentiment make life easier for criminals and more risky for law-abiding citizens, and they also make it more unsafe for police, and it must stop, and it must stop now, ' he said. Whether it's law enforcement or military. "You'd be the first to know", he said, reports The Hill.
Trump also heralded recent declines in unemployment as a positive step toward lower crime rates.
Tarm reported from Chicago.


text:
Golf is a game of skill that can take years, if not decades, to master. Many golfers find their time on the golf course both rewarding and relaxing, even on those days when the fairways seem impossible to find.
Though many players never swing a golf club until they reach adulthood, it's never too early to hit the links. Some of the world's most accomplished golfers, including four-time Masters champion Tiger Woods, began playing as toddlers, and many feel that getting an early start can lead to a more successful game down the road.
To read more please log in or subscribe to the digital edition https://www.etypeservices.com/Kerens%20TribuneID366/

domain: sports


Two Senators Blame State Department in Sept. 11 Attacks
AP Website Requires Payment
to View Article
Free Copy Given Below
This is one of the documents on the 9/11 summary for which the media website requires payment. You must pay a small fee by credit card on line in order to be able to download this document from the Associated Press website. Go to:
Click on "advanced search". Type "Two senators blame." Then select the date as 12/18/02 in both date boxes and click on the Search button. We provide a free copy of the article below.
Two senators blame State Department in
Sept. 11 attacks
KEN GUGGENHEIM; Associated Press Writer
WASHINGTON (AP) - The Sept. 11
attacks would not have happened if the State Department had followed
its own guidelines and denied visas to the hijackers, two top
Republican senators said in a report issued Wednesday.
Sens. Jon Kyl and Pat Roberts said in a report that "the answer to the question—could 9/11 have been prevented—is yes, if State Department personnel had merely followed the law and not granted non-immigrant visas to 15 of the 19 hijackers in Saudi Arabia."
If U.S. laws had been followed, "most of the hijackers would not have been able to obtain visas and 9/11 would not have happened," they said.
They said the hijackers should have been denied visas as single young men with no visible means of support.
Many lawmakers have criticized the State Department's handling of visas for the hijackers. But the criticism by Kyl and Roberts was among the most blunt in tying the issuance of the visas to the failure to stop the attacks.
There was no immediate comment from the State Department. State Department officials have said previously they had no reason to believe the men were terrorists and that their visa policies have been improved since the attacks.
Roberts and Kyl are members of the Senate Intelligence Committee, which along with its House counterparts, conducted the inquiry into intelligence failures leading up to the attacks. Roberts, of Kansas, will likely be the committee's chairman next year; Kyl, of Arizona, will have a top position in the Senate leadership.
Their comments were included in a supplemental report to the inquiry's findings, which were completed last week. The committees found that intelligence agencies were poorly organized and slow to pursue clues that might have led to the attacks. They recommended creating a Cabinet-level national intelligence director to improve communications among agencies.
In a separate supplemental report, Rep. Mike Castle, R-Del., also criticized the State Department, saying most of the hijackers were wrongly admitted "as a result of decisions made and errors committed by responsible State Department and Justice Department officers."
Roberts, Kyl and Castle all noted that State Department's actions was not part of the inquiry, which was limited to intelligence issues. A newly formed commission headed by former New Jersey Gov. Thomas Kean will examine immigration and other issues related to the attacks.
Kyl and Roberts also criticized the recently completed congressional investigation of the Sept. 11 attacks, saying it didn't dig deeply enough into intelligence problems. They said intelligence committee leaders excluded lawmakers from key decisions during the investigation.
KEN GUGGENHEIM; Associated Press Writer
Two senators blame State Department in Sept. 11 attacks, 12-18-2002
FAIR USE NOTICE: This site contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available in our efforts to advance understanding of criminal justice, political, human rights, economic, democracy, scientific, and social justice issues, etc. We believe this constitutes a 'fair use' of any such copyrighted material as provided for in section 107 of the US Copyright Law. In accordance with Title 17 U.S.C. Section 107, the material on this site is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes. For more information go to: http://www.law.cornell.edu/uscode/17/107.shtml. If you wish to use copyrighted material from this site for purposes of your own that go beyond 'fair use', you must obtain permission from the copyright owner.
See our exceptional archive of revealing news articles.
Please support this important work: Donate here.
www.momentoflove.org - Every person in the world has a heart
www.personalgrowthcourses.net - Dynamic online courses powerfully expand your horizons
www.WantToKnow.info - Reliable, verifiable information on major cover-ups
www.weboflove.org - Strengthening the Web of Love that interconnects us all
Subscribe here to the WantToKnow.info email list (two messages a week)
Two senators blame State Department in Sept. 11 attacks


text:
Insights: News Releases
Kilpatrick Townsend’s Kimberlynn Davis Named to The Atlanta Intellectual Property Inn of Court
ATLANTA (September 11) -- Kilpatrick Townsend & Stockton announced today that attorney Kimberlynn Davis has been named to the Atlanta Intellectual Property Inn of Court.
Established in 2010, the Atlanta IP Inn of Court serves as a forum for advancing professionalism, civility, ethics and legal excellence in the Atlanta IP legal community. The Atlanta IP Inn of Court fosters collegiality between its members and the judiciary. The Atlanta IP Inn of Court is a member of the American Inns of Court and the Linn Inn Alliance of National Intellectual Property Inns. For more information, please click here.
Dr. Davis focuses her practice on prosecuting foreign and domestic patent applications in the chemical arts, due diligence and freedom to operate analysis, and client counseling and portfolio strategy for companies, universities and research institutions. While attending graduate school, she designed and synthesized nucleoside analogues as HIV-1 reverse transcriptase inhibitors and also focused on developing methodology to improve the regioselectivity of nucleoside base couplings under advisor Dr. Dennis Liotta. Dr. Davis also served as an intern in the Emory University Office of Technology Transfer, where she assessed the marketability and patentability of technologies. While attending Xavier University of Louisiana, Dr. Davis worked as a summer intern in medicinal chemistry at Eli Lilly and Company.
For more information about Kilpatrick Townsend, please visit: www.kilpatricktownsend.com.
Follow the firm on Twitter: @KTS_Law.
Kimberlynn B. Davis, Ph.D.

domain: law


Reforms that would force newspapers to pay legal costs in court cases even if they win pose a potential threat to press freedom, Holyrood’s Culture Secretary has warned.
Fiona Hyslop called on the UK Government to “carefully consider” the impact its Section 40 proposals would have on both the media and democracy.
She confirmed the Scottish Government has no plans to bring in the changes north of the Border, pointing out Scotland has its own distinct legal system and that press regulation is devolved.
Despite this, she said the changes, contained within Section 40 of the Crime and Courts Act 2013, could damage Scottish local and national media if they are brought in by Westminster.
Ms Hyslop said: “Despite press regulation being devolved, Scottish local and national media could be impacted by any decision to enact section 40 in England and Wales, and it is my view that the measures consulted on by the UK Government would put at risk the viability of much of our independent media, particularly local newspapers, and pose a potential threat to freedom of the press.”
She stressed “Section 40 of the Crime and Courts Act does not apply under Scots Law” and added: “We have not introduced statutory measures to incentivise participation in the regulatory system, as has happened in Westminster, and I can confirm we have no plans to do so.”
She made the comments after Scottish First Minister Nicola Sturgeon said she did not support the implementation of Section 40 – which could see newspapers not signed up to an officially-recognised regulator pay the legal costs of both sides in libel and privacy actions brought against them.
But the SNP Westminster group stopped short of fully endorsing Ms Hyslop’s approach saying party MPs would “consider carefully” proposals on press regulation that come forward from the UK Government.
“While press regulation and the operation of the courts is devolved to the Scottish Government and Section 40 will not be introduced in Scotland, the UK government consulted on a range of options and SNP MPs will look at any proposals that come forward based on a balance of proper redress for victims and protection of the freedom of the press,” said a statement from the SNP Westminster group.
Newspapers that are part of a recognised regulator would be exempt from the measures.
The proposals have divided opinion between those who believe the measures are ‘’fair’’ and those who fear they will severely limit the scope for newspapers to conduct investigative reporting to expose corruption and wrongdoing.
Most newspapers have signed up to the Independent Press Standards Organisation, the press-funded body which has not sought official recognition, and would therefore be faced with paying plaintiffs’ costs under the Section 40 provisions.
The UK Government has carried out a consultation into the measures.


text:
Plum Village - Lower Hamlet
- Address: Meyrac, 47120 Loubès-Bernac, France
- Phone: +33-553947540
- Ticket Price: Free
- Tags: Religious Site, Temple, Family And Kids, Point Of Interest
A famous Buddhist Temple in Loubes-Bernac, Plum Village is situated bang in the middle of a beautiful province in Southern France. Founded by Vietnamese monks, it was established in the year 1982. There are various retreats that take place here. It is in the vicinity of Bordeaux and you can definitely consider this attraction if you visit the wine city of France. Remember to follow the dress code as they are quite strict with it. If you are looking for tranquillity and serenity, then this attraction should definitely be considered.
More about LoubÃÃƒÂ¨s-bernac
Personalize your visit to the city by chalking out a plan using LoubÃÃƒÂ¨s-bernac trip planner.
Your worry of where to stay in LoubÃÃƒÂ¨s-bernac is sufficed by bunch of interesting and comfortable lodging options in the LoubÃÃƒÂ¨s-bernac like La Villa Saint Laurent, Relais Des Vigiers and ChÃÃƒÂ¢teau Des Vigiers.
- Walk or drive to this attraction.
Love this? Explore the entire list of things to do in Loubès-bernac before you plan your trip.
Fancy a good night's sleep after a tiring day? Check out where to stay in Loubès-bernac and book an accommodation of your choice.
It was very good to come here for a week and rest and build up our capacity for mindfulness and compassion. It feels like I can communicate with more compassion and listen more attentive after being here. The nuns who live here really makes an effort to meet everyone lovingly, and the food is awesome! :)
A wonderful place to be and practise mindful living. Feels like home every time I go.
Having just reserved a return visit to lower hamlet ( I attended for two weeks last year ) I find myself glowing in anticipation, just the thought of being there once more . As my five star rating implies , I love the joy & teachings from all there .
Honestly the best time I ever had in all my life was in the only week I went to this incredible place. Its everything that's good about the world in one place, and makes sense of when people say heaven is on earth! Who ever you just go!
it is very very spectacular! Thay Nhat Hanh is my teacher forever!

domain: geography


text:
The company's portfolio was expanded by another international oil and gas summit in Iran, which, like its Dubai
predecessor, brought together representatives from many countries, and Russia was represented by the largest
delegation. Also this year, we expanded our portfolio with the Russian Energy Summit and the inter-industry Summit "Digital Plant".
At the end of the year, they were included in the list of leaders among organizations of industry conferences in the Russian
market according to an independent study by the inside conference agency.

domain: news


text:
NelsonArtists.co.nz for fine art paintings, sculpture, ceramics, contemporary new zealand jewellery direct to you by Nelson and New Zealand artists.
Nelson, Susan *
Nelson, Susan. Susan Nelson
Susan Nelson, painter, was born in Canada and now lives in Auckland.
Newby, Kate *
Newby. Kate. Kate Newby
The Auckland Art Gallery
The Adam Art Gallery
NZ Art Guild
The NZ Art Guild is a nationwide group of New Zealand artists. The members are diverse in genres, styles, mediums and career stages, ranging from full-time accomplished artists to part-time emerging ones.
Nicholas, Darcy *
International Art Centre, Auckland.
Nigro, Jan *
Nigro, Jan. Jan Nigro
Auckland City Art Gallery collection.
Article in The New Zealand Herald.
Remuera Gallery, Auckland
Jane Sanders, Art Agent
Novak, Brad *
Novak, Brad. Brad Novak
Brad Novak is a self-taught professional artist exploring the relationship between colour, shape, and contrast. His broad choice of subject, ranging from the culture and landscape of Aotearoa, to sea animals and more recently human anatomy, reflects his love of the natural world. Brad’s original paintings on canvas are created through purposeful over-layering of designated masked areas with repeated layers of paint.
Novak, Caz *
Novak, Caz. Caz Novak
New Zealand artist Caz Novak paints vibrant contemporary landscapes featuring coastal New Zealand and lush gardenscapes. Her abstract paintings utilise both impasto paint and transparent washes of colour and can be found in international collections. As a colourist, Caz’s works are in demand with interior designers.

domain: artistic


text:
So…this weekend Gossip Girl actress Blake Lively was spotted out and about in New York City in some pretty fab looks. Many fashion outlets (US Weekly, Harper’s Bazaar, Cosmopolitan) are declaring her the most fashionable pregnant celebrity ever….
|collage courtesy US Weekly|
Blake Lively puts all other pregnant women to shame: http://t.co/rjpZBDClZU
— Us Weekly (@usweekly) November 10, 2014
This stunning new photo of Blake Lively’s baby bump is so perfect you will CRY TEARS OF JOY: http://t.co/qRh9oDiTij pic.twitter.com/ZX1PwtGSG8
— Cosmopolitan (@Cosmopolitan) November 9, 2014
*eye roll* Cry? Really, Cosmo??
Anyway, not so fast!
Lively, who is expecting her first child with husband Ryan Reynolds, did look fab in her Michael Kors cropped top and white flare embroidered daisy skirt, topped with a Thomas Sires coat and accented in vintage Christian Louboutin pumps and a bold turquoise statement necklace.
But I’m not gonna cry tears of joy over it.
As a matter of fact, I still maintain that Miroslava Duma former editor of Harper’s Bazaar Russia was the most stylish pregnant “celebrity” ever.
And I also maintain Instagrammer Up Close and Stylish who boasts over 1 million followers was the most stylish social media celebrity when pregnant and is still unseated.
That’s my opinion. Anyone beg to differ or have proof otherwise they’d like to share? Hit me up in the comment section.

domain: celebrity


Lamb & Hayward Masterworks
Berlioz Overture ‘Le Carnaval Romain’ — Saint-Saëns Piano Concerto No. 5, Op.103, F major (Egyptian) — Dvořák Symphony No. 7, Op.70, D minor
Luke Dollman Conductor — Somi Kim Piano
A pre-concert talk is available to all ticket holders on the night of the concert at 6.40pm in the Ron Ball Studio, Christchurch Town Hall.
The Roman Carnival Overture is one of Hector Berlioz’s most popular works and is considered one of the greatest showpieces in the orchestral repertoire.
Saint-Saëns enjoyed escaping the unappealing Parisian winters and traveling to warmer climes including Egypt, where he completed his fifth Piano Concerto in Cairo in 1896. This refreshingly cheerful work will be performed by Somi Kim, who has established herself as one of today’s most highly regarded young pianists with a string of competition successes and an extensive concert experience.
Arguably Dvořák’s finest symphony, the D minor symphony represents a mastery of form equal to that of Schubert or Brahms but explores a deeper meaning than audiences had come to envisage from the writer of popular Slavonic dances. This work is typically full of wonderfully spacious melodies and a wealth of thematic ideas.
For each concert in our Lamb & Hayward Masterworks series, we have a pre-concert talk available to all ticket holders at 6.40pm in the Ron Ball Studio on the night of the performance.
We’re keen to keep our musicians safe and the music playing in 2022, so we strongly encourage mask wearing at all concerts.


For those who aren’t accustomed to blog writing, it is an easy text style in which distinct diary-style entries are published. Blogs are generally displayed backwards chronological order, with one of the most current article showing up at the top of the web page. While the material of a blog is totally as much as the owner, there are lots of benefits to maintaining a blog site. Along with tracking topics of rate of interest, blog owners can gain a lot of money.
The first advantage of blogging is that it is an easy method to share details with others. It is easy to establish and calls for little to no technical knowledge, as well as is excellent for developing a sense of area. A blog will permit you to share your ideas and concepts with the globe. It is not just an exceptional method to showcase your expertise, but will additionally help you produce a link with others. There are numerous kinds of blog sites, which can be very helpful.
There are various sorts of blog sites, consisting of personal and also organization blog sites, online diaries, and also also social and political ones. People from all walks of life can produce a blog, as blogs typically integrate text, digital photos, as well as web links. Some blogs can serve as an abundant source of details, while others can function as an on-line diary or brand advertising and marketing. A blog is a way to share your ideas and opinions with others as well as is a great method to network.
One popular kind of blogging is wikis. It is a collaborative room where a single person can edit web content and also share it with others. The blog will certainly work as a primary resource of web content. It is additionally utilized for opinion-forming, which assists a company end up being an expert in their industry. A blog will improve customer fulfillment. It will certainly raise your site’s exposure in internet search engine. This will certainly also raise brand understanding. It is easy to use.
A blog site can boost your internet site’s visibility in search engine results. A blog site permits you to boost your web website traffic. In the past, numerous businesses didn’t use blogs to increase their earnings. They viewed the benefits of having a blog as a beneficial tool for marketing a services or product. However, the appeal of blogging has actually grown over the last few years, and now several business owners are establishing a blog in order to boost their on the internet visibility.
As the appeal of blogging boosts, the threats connected with it have boosted. Boosting your blog site’s visibility is a terrific method to generate income. A successful blog will certainly have a high level of traffic, as well as an excellent SEO position. Utilizing blog sites to advertise an organization is a great way to improve sales. The Web is a fantastic means to promote products and services. The appeal of a blog is very associated with its readership.
Not just is blogging a terrific way to market a services or product, however it likewise allows you to reach a larger target market. It is additionally a good ways to express one’s concepts. With the growing appeal of blog writing, it has ended up being progressively important to watch on the success of a blog site. This means that it has the prospective to be successful. It is the best means to attract visitors. It can help you expand your organization.
It’s a wonderful way to influence the general public’s point of view. It’s not just a fantastic way to market a product, but it’s a wonderful device for developing a brand name. It provides people the chance to share their sights on a variety of subjects as well as items. A blog site can be utilized to promote a service or product. So many companies are currently implementing this technology. It’s important to comprehend that the importance of a blog can not be undervalued.
It can be a reliable method to connect with many individuals. It permits writers to reveal their enthusiasm by connecting with many readers. Whether it’s a personal or service blog site, a blog site can get to millions of viewers. Hundreds of countless blog sites are currently online. So, if you wish to increase your audience, blogging can be a terrific means to do it. Actually, it is a fantastic method to reach an international target market.
Some people utilize a blog site to promote essential concerns. As an example, a blog can raise awareness about a condition or raise funds for a charity company. Some individuals likewise use it to review their favorite topics. It is necessary to comprehend the purpose of a blog. There are several ways to obtain publicity. There are some blog owners that use a blog for personal factors. A company owner can also make use of a blog site to spread recognition about a topic.
While a blog can be a wonderful resource of info, some individuals find it bothersome when they need to read their very own blog sites. A blog site can be a powerful tool to help them promote a particular item. In addition to this, a blog can be an effective means to share concepts with customers. The blog site is a beneficial tool for promoting an organization. On top of that, it can help an organization advertise a brand name as well as increase income.
For service functions, a blog can be extremely important. Regardless of its advantages, a blog site can be a superb marketing tool. As an example, a business can utilize the blog to advertise a services or product. If an employer can market a service or product with a blog, it will certainly show up to consumers and also will enhance sales. However, a blog site can additionally be an effective means to advertise a company’s brand. It will certainly help a business gain much more direct exposure.
A blog can be an useful source for advertising and marketing. It can assist a service increase its visibility and boost web traffic. The benefits of blog writing are lots of and include a series of various chances for business owners. The blog can likewise be used to market services or products to a specific target audience. The blog owner can produce the material for his/her blog site and also promote the service or products through the blog. As an example, an effective online service needs to offer an effective blog. Visit this page
A blog site is a fantastic means to promote an organization. A blog site can attract customers to your service. Most of the moment, a blog site will include web links to other websites as well as organizations. This will assist companies promote their products or services. When a brand succeeds, it will take advantage of the blog’s traffic. This will certainly raise sales. The company will have the ability to increase its exposure. It will be able to broaden their brand’s reach.


Cassie Mitchell competes in the discus throw at the U.S. Paralympic Trials in June. The biomedical engineering assistant professor is headed to her third Paralympic Games this year, where she hopes to complete her medal set with a long-sought-after gold in discus or club throw. (Photo Courtesy: Mark Reis/U.S. Paralympics Track & Field)
It’s pretty much gold medal or bust for Cassie Mitchell at the 2021 Paralympics.
The biomedical engineering assistant professor brought home a silver and a bronze medal from Rio in 2016 after a few fourth-place finishes in the 2012 London Games, but you never know when it may be your last chance to compete on the world’s stage. So, on this third trip to the elite Paralympic Games, Mitchell has her eyes on the top of the podium.
“I have World Championships gold medals, world titles, world records, and Paralympic medals. But I don't have the Paralympic gold medal,” Mitchell said. “And it's not just the gold medal, itself. I want to see the American flag raised; I want to hear our national anthem. It's the process and what it means to ‘never, never, never give up’ to reach the top, and to compete with honor for the USA. I'm sentimental and very patriotic when it comes to competing for Team USA.”
Mitchell will compete in two events in Tokyo during the Paralympic Games Aug. 24-Sept. 5, the club throw and the discus throw. Already, she’s having quite a year: she’s No. 1 in the world in both events for her F51 classification, and, in May, she set a new world record in the women’s F51 discus.
Maybe things are shaping up just right for her to hear “The Star-Spangled Banner” in Japan.
“I have to hedge: I'm currently No. 1 in the world this year in club throw, but the F51 club throw world record holder is Zoia Ovsii, and she has thrown 2 meters farther. She hasn't done it in competition this year, but that doesn't mean she won't. It also doesn't mean that I won't go and have a breakout performance in Japan,” Mitchell said. “As an athlete, I've learned that you have to control what you can control. I can control my attitude, my work ethic, my choices.”
Mitchell won a bronze medal in club throw in 2016 and a silver in discus. She suspects her best shot at gold this year will be in F51 club throw.
Paralympic athletes are grouped into classifications according to their disability. Mitchell is classified as a 51 athlete; they are the most severely disabled athletes who have impairments in all four limbs. (The "F" refers to field athletes.) However, unlike F51 club throw, several classifications have been combined for the discus event. That means Mitchell will face other athletes who are less disabled: “It probably will take a F51 world record to get a medal in the combined F51-53 discus event, based on current world ranking performances. I would likely need to throw another F51 world record to get into bronze. But you never know.”
Mitchell is a faculty member in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, where her research focuses on harnessing the power of big data and machine learning to forecast disease, identify new therapeutics, and optimize treatments. Her work is at the intersection of engineering, data science, and pathophysiology — she calls herself a “pathology forecaster.”
Left: Assistant Professor Cassie Mitchell prepares for her discus throw at the Paralympic Trials in June, where she secured a spot on Team USA for the 2020 Paralympic Games in Tokyo. Mitchell will compete in discus and club throw, events where she’s currently ranked No. 1 in the world in her classification.
Above: Mitchell says club throw is perhaps her best shot at a gold medal at the 2020 Games. Gold would complete Mitchell’s medal set after she won bronze in club throw and silver in discus in 2016. Here, Mitchell competes in the club throw at the U.S. Paralympic Track & Field Trials in June.
(Photos Courtesy: Mark Reis/U.S. Paralympics Track & Field)
Mitchell has always been a talented athlete, even before an autoimmune disorder left her paralyzed at age 18. Instead of gymnastics, track, and equestrian events, Mitchell was forced to shift to wheelchair sports — and it turned out, she was very good. Over the years, as her disease progressed and the landscape of Paralympic sports shifted for quadriplegic athletes with Mitchell’s level of disability, she found herself switching from cycling to track events and finally to throwing.
Along the way (just before the Rio Games, in fact), Mitchell was diagnosed with leukemia. Like everything else, though, she hasn’t let that stop her. In fact, competing has helped her quality of life as she fights the cancer, she said.
“Oncologists have said most people in my condition, even now as I do treatment, struggle to get out of bed, much less go and train at an elite level. I think that the act of training and competing — it's not just about the medals, but how it helps you in other ways mentally and physically as well,” Mitchell said.
For many athletes, the coronavirus pandemic disrupted a fairly regimented four-year rhythm of trying to make it to the Olympics or Paralympics. Mitchell said she surely would’ve preferred to skip the pandemic and the havoc it has wreaked on people’s lives and families. But the extra year has given her a chance to reflect on why she competes and stoked her competitive fire.
“I've always been one to push myself, but I find I have a really exceptional desire to push forward this time, even maybe greater than I would have had last year,” Mitchell said. “I think that's [the result] of losing one of the things that you love to do: You remember, I didn't start competing just to get a medal; I started doing it because it was fun.”
The extra year of practice has Mitchell set up well. She mostly was able to continue training since her events are a naturally socially distanced individual sport. She trains outside with the aid of a trusted personal care assistant. It’s also given her a chance to apply her engineer’s mind to her athletic endeavors.
“I am not a research expert in biomechanics, but I do specialize in biomedical data science. I definitely use analytics to tweak my technique,” she said. “I do an engineering analysis on all my throws. I have pages of math and simulation. Sometimes the engineering analysis is spot on, and sometimes what is mathematically optimal is not physiologically possible for me. But, overall, I do think my engineering perspective has made me a better thrower.”
In the meantime, she’ll continue to balance the demanding world of academia with the demanding world of elite international athletics — even when it means teaching bioengineering statistics from her car at the U.S. Paralympic trials. She said sometimes she wishes she could isolate the two worlds — academics and sports — and focus on one at a time. Mostly, though, she finds them to be a synergistic combination.
“The athletic endeavors keep me from getting overly consumed with the often fiercely competitive academic environment, and vice versa. It gives me balance in my life."


text:
As we settle into the new normal, it becomes more and more easier to buy weights online and to have the best home gym setup for your budget. You might still have to look a bit harder to find the best Bowflex deals, but as opposed to how things were in April, the availability of the best home weights and best kettlebells look much better nowadays.
That said, although price drops might happen on Amazon Prime Day, Black Friday and Cyber Monday, you are better off buying weights sooner rather than later, considering some governments are toying with an idea of a second lockdown and we all know what happened to weight-availability when that happened last time.
Many sought-after models, including the Bowflex Selecttech 1090i dumbbells and the equally versatile Bowflex SelectTech 840 kettlebell, are still on short supply, but if you're vigilant – and quick – enough, you can still find excellent home weight deals at selected retailers, with Fitness Superstore, Argos and JTX Fitness leading the charge. Even Amazon has some great home weight deals on sometimes!
• Buy treadmills online: the best exercise bike, rowing machine and fitness equipment deals with home delivery
Buy weights online: the best online retailers
We already knew JTX Fitness had a range of cardio machines but as it turned out, they stock resistance training equipment, such as suspension trainers and dumbbells too! They have just recently restocked so you'd better head over and buy some dumbbells and kettlebells while you can.
FitKit has a range of free weight and home gym accessories in stock, including the best barbells from Jordan Fitness and Ziva completion dumbbells.
Mirafit is one of the best home gym equipment providers in UK and most usually has plenty of stock too, but due to the sky-high demand for such stuff nowadays, they are just as out of stock of home weights and best weight benches as everyone else. Nevertheless, the Mirafit website gets updated frequently so it is worth having a look every now and then.
Fitness Superstore has the most comprehensive supplier network and therefore this store is most likely to receive stock before other outlets. At the moment, delivery time frames are up to seven working days and most of the brick-and-mortar Fitness Superstore shops are open for business.
Having a look around for anything at Amazon is always a good idea. Granted, the online retail giant is not too famous for stocking quality gym equipment, but you can still find good deals on the best pull up bars or best ab rollers if you look hard enough.
Argos' website is particularly painful to browse, items will appear as 'in stock' when in fact most usually there is only one left in a remote store in Northern Scotland. Nevertheless, Argos sells decent quality cheap multi gyms and who knows, you might get lucky.
Now, it is not often we say this, but have you considered shopping at Sports Direct? They don't just sell Lonsdale tracksuits, contrary to popular belief, and have a surprising amount of home gym equipment, such as the best resistance bands, left to buy, with free delivery on orders over £50.
We recommend always checking delivery times and T&Cs before you make a purchase at any of the above shops. Avoid disappointment and read the small print before you hit the "Buy now" button.
- Under Armour SPORTSMASK review: face mask for exercise and running outpaces normal coverings
- ASICS Runners Face Cover review: the BEST face mask for runners in 2020 so far
- UA SPORTSMASK vs ASICS Runners Face Cover: which is the better face mask for runners?
Best cheap kettlebell deals
Build functional muscles using kettlebells. Should you need some inspiration where to start you can try the best kettlebell workout for beginners or this six-step kettlebell arm workout, maybe even this full-body kettlebell workout from a Master Trainer or best kettlebell workout from senior kettlebell specialist Eric Leija.
- Shop kettlebells at the Fitness Superstore
- Shop the JTX Fitness kettlebell range here
- Shop kettlebells at Onnit (US)
- Shop kettlebells at House of Fraser
- Buy kettlebells at Ebay
- Shop kettlebells at Amazon
AmazonBasics Cast-Iron Kettlebell | Prices from £12.46 at Amazon
It doesn't get more basic than AmazonBasics but since kettlebells are basically just a lump of iron with a handle, you can't really go wrong with getting AmazonBasics cast-iron kettlebell. The most popular 16-kilo variety is only £30 which is dirty cheap, but even the heaviest 20kg version is only £45. That's a bargain if I ever saw one in my life.View Deal
JTX Neoprene Covered Kettlebell | Prices from £29 at JTX Fitness
16-kilo kettlebells disappeared from the face of the earth in April. Seeing them in stock again is like Christmas came early for anyone interested in home resistance training. Using just one kettlebell, you can get fit and lose weight at the same time with this 4-week kettlebell workout. Get fit now!View Deal
ONNIT Primal Kettlebells | Prices from $42.95 at Onnit
Get primal with the ONNIT Primal Kettlebells. You won't have time for monkeying around too much as these capable kettlebells not only look good but are also highly-functional: made of chip-resistant iron, ONNIT Primal Kettlebells will stand the test of time. Nad, I mean, they just look awesome too.View Deal
Mirafit Cast Iron Kettlebell | Prices from £14.95 at Mirafit
What not to like in these cast iron kettlebells from Mirafit? It has a powder coated finish and a nice fat grip so you can strengthen your grip as well as all the muscles in your body. Flat non-wobble base ensures this 'bell won't roll away when placed down. Available in a range of weights from 4kg to 32kg.View Deal
Jordan Fitness Chrome/Rubber Kettlebell | Price from £17.99 at FitKit
Want to go heavy? This 20-kilo Jordan kettlebell will provide enough resistance for your functional training sessions. This kettlebell has a smooth chrome handle which is great to grip (might be slippery when wet/sweaty though), a gravity cast iron core and balanced bottom so it can be set down easily. The rubber outer shell is hard floor- and neighbour-friendly.View Deal
Mirafit 3pc Kettlebell Weight Set with Stand (2.2kg, 4.5kg & 6.8 kg) | Buy it for £47.99 at Amazon
Can't go wrong with Mirafit! This kettlebell set is on the light side so ideal for beginners, muscle toning and one-handed exercises. Included in the price is the storage stand so you can put your kettlebells on display in the living room for when your friends can finally visit you again, subtly hinting that you have been working out hard in the last three months.View Deal
Eleiko Training Kettlebell | Prices from £24 at Eleiko
If it's good enough for Olympic competitions, it's good enough for us. The Eleiko brand has been trusted by official weightlifting associations all over the world for a number of years by now for its quality and reliability. This cast-iron training kettlebell does what it says on the box: use it for any manners of functional training and rest assured that the double moulded will provide a consistent texture across the entire surface that holds chalk well and ensures a good grip. More sizes available at Eleiko (not all, though).View Deal
- JaxJox KettlebellConnect review: a rack of weights in one smart unit
- Bowflex SelectTech 840 kettlebell review: your new hom
- Get big arms FAST with this 3-move kettlebell arm workout that also improves grip strengthe gym staple weight
Best cheap dumbbell deals
Dumbbells are super versatile home gym equipment and with just a pair, you can essentially train your whole body. How about trying the best home dumbbell exercises for beginners or this dumbbell workout for fat loss and muscle building, maybe the best biceps and triceps workout for home gyms?
- Shop dumbbells at Amazon UK
- Shop dumbbells at Fitness Superstore
- Shop the JTX Fitness dumbbell range here
- Shop dumbbells at Argos
JTX 10 kg Dumbbells (Pair) | Buy it for £64 at JTX Fitness
At the same time kettlebells were removed from existence, they took all the decent sized dumbbells with them too. Getting quality 10-kilo dumbbell pairs for a reasonable price was almost as impossible to get toilet paper in April. Not anymore, though, as JTX Fitness has restocked its dumbbell selection including the coveted 10 kg pair which can be bought for £64 now. Not for long, probably.View Deal
METIS Hex Dumbbells | Prices from £19.99 at Amazon
What a find at Amazon! The METIS hex dumbbells are available to buy or pre-order in a range of actually useful sizes. the 10-kilo variety is £99.95 and can be delivered by Saturday 13 June. Not sure if these are pairs or individual dumbbells, you'd better double check this with the seller first.View Deal
- Bowflex Selecttech 1090i dumbbells review: the Rolls Royce of dumbbells
- Men's Health Cast Iron Adjustable Dumbbell Review: Bowflex just got a problem
Best multi gym and suspension trainer deals
TRX PRO 4 Suspension Training Set | Buy it for £199.95 at TRX
A step up from the excellent TRX HOME2 set, the TRX PRO 4 has it all TRX has to offer for home gyms: adjustable foot cradles, rubbed-rubber handles, theft-resistant carabiner, industrial-grade reinforced stitching and comes complete with a suspension- and door-anchor attachment.View Deal
Rhinosport Sling Trainer Set | Buy it for £43.23 at Amazon UK
Here is suspension trainer set from Rhinosport for a mere £43; although we haven't tried it yet, it is reviewed well at Amazon so there is hope it won't snap after one use. Suspension trainers are the cheapest way to introduce some variety to your indoor bodyweight training and they are especially good for a core workout blast.View Deal
Best cheap weight bench deals
Bowflex Xtreme 2 SE Home Gym | On sale for £899 | Was £1,349 | You save £450 at Fitness Superstore
Using Bowflex's trademark Power Rod, the Bowflex Xtreme 2 SE Home Gym is more quiet than a 'regular' multi-gym yet provides a decent workout nevertheless. Not only it is more quiet but the Xtreme 2 SE is also has a space-saving construction too. It is still rather large, mind, but not quite as big as some models with leg presses and such.View Deal
Body-Solid PowerCentre Combo Bench | On sale for £359 | Was £495 | You save £136 at Fitness Superstore
There is a lot going on here: the PowerCenter Combo Bench is a squat rack, flat bench, incline bench, decline bench, 90° shoulder press bench, and seated leg developer (pictured Olympic adaptor sleeve optional) all in one. You will need a bit more floor space to house this unit but by buying this, you can have a full gym with just one equipment and some some weights.View Deal
Other notable resistance training and fitness equipment deals
- Amazon Prime Day 2020: date and best deals to expect
- Best Black Friday deals: shop the best Black Friday 2020 sales


text:
Looking back on a few highlights from the past year that I didn't post at the time included an early Summer visit to a couple of Sussex heathlands hoping to catch up with some Dartford Warblers. This species seemed to have done quite well over the past few years in Sussex and walking around both of the heaths several birds were seen. All apart from one were quite long distance and the photos are a little more cropped than I would have liked, but they still show what a beautiful species they are. The final bird that I photographed was a bit nearer. This one I found as I was walking along a path when I heard the bird calling loudly. Creeping into an area of Gorse it became clear why it was calling so loudly, as it was having a heated argument with a Willow Warbler!!
Dartford Warbler on Gorse.
Dartford Warbler having an argument with a Willow Warbler.

domain: biology