it's hardware. The only thing you can do yourself (but it IS rather expensive) is to try a new battery. If it's not that, back to Dell.
If the battery is OK (you've got 2 then), and you don't like the repair scenario, see if you can buy another charger. Either a full Dell XPS (rather expensive also, you now have got 2 laptops and 3 batteries) or something like http://accessories.us.dell.com/sna/products/Power/productdetail.aspx?c=us&l=en&s=biz&cs=555&sku=A1214550 but than for YOUR type of laptop battery (this particular one is for some Inspirons and Latitudes).
I posted this problem in Dell Forum but got no response. Maybe some of you have idea on what steps I should take to eliminate this issue.
The notebook is
Dell XPS 13 Intel Core 2 Duo P8600
4GB DDR3 memory
Ok, forget about warranty because I bought it in US and it said that if I bring it outside US, the warranty is voided. I use it in other country.
The laptop if working fine and fast when it's either on battery OR if connected to adapter only (without battery). BUT when I plug both battery and adapter (basically using it while charging), after 30-60 seconds, it will act like in slow motion. It's really obvious especially when I switch between windows or opening a folder. It's like some huge process is going on in the background. BUT when I check the task manager, the CPU is not busy at all. I tried system restore, even clean install my Vista 64 with no help at all.
So, now I only use it without battery and this one becomes desktop replacement sittin on my desk.
Anyone has any idea on what I should check?


The All-New Drymax Trail Running socks are true to their storied trail heritage, combining the tried-and-true Drymax Dual Layer Sweat Removal System with sturdy construction for the toughest of conditions. This sock is a beefed-up version of the Lite Trail sock. Advancements of Drymax's knitting techniques have resulted in the Trail Running sock feeling even softer and yet more durable. Denser yarns and a seamless foot and toe envelop the foot in comfort and security. The 1/4 Crew features Drymax's protective double knit leg to reduce debris entering the shoe, while the Turn Down leg feature makes for a cooler run on a hot day.
These Drymax socks are engineered to provide three benefits: 1) a 3D advanced fit which includes up to five sizes; 2) seamlessly smooth fibers that provide an anti-blister system, and 3) fibers that contain MicroZap silver antimicrobial designed to fight odor-causing bacteria. Together, these benefits combine to make Drymax socks the #1 sock to keep feet dry.
65% Drymax Olefin, 20% Polyester, 8% Nylon, 7% Elastane


A Cornishman arrested in Bali for allegedly smuggling cannabis oil has said he has “never been so afraid” as he faces up to 15 years in an Indonesian prison or possibly even the death penalty.
Pip Holmes, a 45-year-old artist, was one of five foreigners paraded at a news conference last week in Denpasar, the capital of Bali province.
Mr Holmes had a hip replacement six years ago and suffers pain from arthritis. He uses medical marijuana to manage the pain as well as anxiety.
His family – who say he was arrested for possessing 31g of medicinal THC oil and not 31kg as originally reported by international media – have set up a crowdfunding-style page to help pay the $78,000 needed for his legal representation.
So far, almost $22,000 has been raised via the Get Pip Back Home website.
Mr Holmes, a keen surfer believed to be from the Falmouth area originally, is married to Michelle and has a young son and daughter.
He sent a personal message to those supporting him from an Indonesian rehab facility admitting he had “never been so afraid”.
“My family, friends and loved ones are constantly telling me that everything is going to be ok and that they’re going to get me the help I need. They keep on saying I’m the strongest person they know and I can get through this.
“But the truth is, I’m afraid. I’ve never been so afraid. It’s hard to be strong when you read the words ‘death penalty’ in the paper in relation to your story.
“I’m also afraid because I don’t know how long it’s going to be before I can hug my children again.”
Mr Holmes added: “For the last few days, each morning I have woken up in a terrible nightmare. I still can’t believe that I’m here and I feel sick with fear.”
He said he didn’t know if he is due to face a short sentence in rehabilitation or a lengthy sentence in Keroboka, “one of the toughest prisons on earth”.
The donation page states that Indonesian law does not discriminate between substances – a tiny amount of medical marijuana and a kilo of cocaine are viewed in exactly the same way.
And Mr Holmes’ friends and family argue it was a small amount – they say the THC oil was weighed in its bottles, which weigh 28g, making the "true amount" of cannabis oil about 3g.
Despite this, he admits to making a “stupid” mistake.
He wrote: “I’ve been in Bali for the last two months, exploring this beautiful island. It’s been an amazing trip and I’ve been creating some wonderful art.
“On Monday, December 3, however, it all went terribly wrong when I was arrested for possession of a tiny amount of medical marijuana oil. Stupid much? Yes very, very stupid.
“Right now I feel helpless and very alone.”
He asked for people to share the Get Pip Back Home Page in order for him to fund the legal representation needed.
“So far [my family and friends] have paid for my legal representation from their own limited funds, however we are not a rich family and funds are now massively depleted.
“As I’m writing this I’m reading it back and it sounds like one of those ridiculous African scams. I assure you it’s not, I’m really here and I’m really, really scared.
“This is Asia, it’s not like the west. I am guilty under Indonesian law of possession of narcotics, there’s no denying that. Even though medical marijuana is something so widely accepted elsewhere and it was such a small amount, I foolishly crossed the line in a very strict country and I am very, very sorry.
“The only possible way now to get a sentence that I can survive is to invest in the right legal representation and hope that they can get me a sentence in rehabilitation instead of prison.”
Admitting he was writing in tears, Mr Holmes added: “I just want to be able to see my kids again. To watch them grow up, to read them stories and squeeze them until they complain. I don’t want to miss another moment.
“I want to be able to play with my stupid dogs, and to hug my lady so hard and never ever let her go.”
If you would like to fund his legal fees or find out more then head to the Get Pip Back Home page.


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Photo via Talib Kweli's Instagram
On November 26, Talib Kweli performed at Pumpehuset in Copenhagen, Denmark. While in Copenhagen, he claims he was the victim of a racially-motivated attack, as he wrote in an Instagram post (via Pigeons and Planes).
"I was attacked by two bigots last night saying they "hate me" and they didn't even know who I was, they just didn't like the color of my skin," he wrote. "It wasn't an Internet attack, it was physical. I was hit and kicked."
Kweli says that he escaped the situation and went on to perform his show as scheduled. "It goes to show you that racism and hate doesn't stop for ppl with money or 'celebrity' whatever that means," he wrote.
Check out the Instagram post below.

domain: celebrity


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RB singerSuran released the highlight medley of her 1st mini album'Walkin'.
The album consists of 5 tracks titled 'Walking'', "1+1=0'', ''Wine'', and more. Singer DEAN, rapper Swings, and Changmohave taken part in some of the tracks while BTS' Sugaproduced the song ''Wine''.
SEE ALSO: [MVP OP:ED] Why do some people perceive male K-pop idols as being Gay?
Listen to Suran's highlight medley in the clip above. The full release coming on June 2.
Get K-POP Merch @ allkpop The Shop

domain: artistic


38 rows · Find album reviews, stream songs, credits and award information for 36 All-Time Greatest Hits – Jethro Tull on AllMusic
BOUREE (Stand Up, 1969) This was the instrumental track on Stand Up, and it reeks of classic …
21 rows · The Very Best Of (Jethro Tull album) The Very Best Of (2001) is a greatest hits album by …
Thick as a Brick. So much beauty in one song! 45 minutes the best song ever without a smidgen …
“Songs From The Wood” has long been my favorite of Jethro Tull’s albums primarily because it’s also one of their most musically interesting as well. Say what you will about Tull but Ian Anderson was always a restless creative spirit and, even when his material didn’t work, it still made for interesting listening.
Jethro Tull new songs, albums, biography, chart history, photos, videos, news, and more on Billboard, the go-to source for what’s hot in music. Billboard Subscribe
Apr 10, 2011 · 19 videos Play all Jethro Tull (Greatest Hits) Vanessa M Jefferson Starship – White Rabbit – 11/8/1975 – Winterland (Official) – Duration: 6:55. JeffersonAirplane on MV 3,704,644 views
Every Jethro Tull / Ian Anderson release in one place. Includes studio albums, live albums, compilation albums and solo albums.
Jethro Tull lyrics – 264 song lyrics sorted by album, including “Aqualung”, “Locomotive Breath”, “Witch’s Promise”.
Greatest Hits. Jethro Tull. September 27, 2010 2.8 out of 5 stars 4 customer reviews First, this is NOT Jethro Tull – this is an album from somewhere by Mick Abrahams (I can’t find it on any discography) or a compilation with him on it at the very least. Mick was Jethro Tulls first guitar player on This Was.


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UNILAG Graduate Killed Day He Received His First Salary
Dr Stephen Urueye received his first salary as a House Officer with Lagos State Teaching Hospital (LUTH) the same day he was stabbed to death, his colleagues have disclosed.
Urueye was among the 8,000 students that graduated at the 50th convocation ceremonies of the University of Lagos (UNILAG) on Wednesday. He died a day later.
Two persons were on Friday arrested as his colleagues protested his killing by armed robbers.
Lagos State Police Command Public Relations Officer (PPRO) Bala Elkana, a Deputy Superintendent (DSP), who described those arrested as “hoodlums,” said they were arrested at the spot where the late Urueye was stabbed.
According to his colleagues, he was the only child of his mother, who is a widow.
He was stabbed near the teaching hospital’s gate, Idi-Araba, Mushin while returning to LUTH by armed robbers, who wanted to rob him of his valuables.
With blood gushing out from his thigh, he ran into the LUTH compound where he was taken to the Accident and Emergency Centre (A&E). He was later transferred to the Intensive Care Unit (ICU).
There, his fellow House Officers and senior doctors battled all through the night to save him. Their efforts proved abortive when he gave up the ghost around 3am on Friday.
The late Urueye’s remains have been deposited at the mortuary.
Emotions ran high in LUTH, Idi-Araba on Friday as soon as news of his death broke with many medical students of LUTH embarking on a protest.
The protesters carried placards with various inscriptions, calling for justice for the victim. According to them, Idi-Araba has been overtaken by armed thugs. They called on the government and security agencies to beef up security in the area.
Some of his colleagues and other Nigerians took to Twitter to lament Urueye’s murder and also seek justice for him with the hashtag #JusticeForStephen.
They lamented that they have complained severally to the management of the hospital as regards incessant attacks of fellow students in Idi-Araba by armed hoodlums.
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Description and amenities
It is one bedroom apartment. It takes 1 minute walk from Opera theatre. There are museums, monuments, cathedrals, theatres, parks nearby. There are numerous cafes, restaurants and pizzerias near the house. There are minibuses and trams stops, manufactured goods and food, souvenir shops, Vernissage. The apartment is located on the 1 floor, with new modern furniture, big double bed with orthopedic mattress and a double sofa bed, central heating (gas boiler), floor heating, TV, satellite TV, Internet, microwave oven, electric kettle, hair dryer, iron, ironing board, cold/hot water, bed, towels, clean entrance. The apartment has armored doors and PVC windows.
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domain: travel


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VA director promises ongoing audits following report
Published: June 13,2014
JACKSON — The director of the G.V. “Sonny” Montgomery Veterans Administration Medical Center says while he’s pleased what VA audit had to say about his facility, the Jackson hospital will continue routine checks on patient care.
The Department of Veterans Affairs found in audit results released Monday patients seeking care through the Jackson medical center waited an average of 45 days for their first appointment with a primary care doctor. The audit found 97 percent of appointments were scheduled in under 30 days.
Jackson VA director Joe Battle says a shortage of doctors has contributed to scheduling delays. He says recruiting doctors is a challenge.
Battle spoke at news conference yesterday in Jackson.
The audit found the average wait time for new patients at the Gulfport VA was about 48 days.
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- Politics of paying for transportation: Hand wringing and a lot of talk
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- Ford Foundation gives to UM for new science building
- Kemper County plant will cost at least another $496M to complete


Le Tour Babe’s Lament
Lance Armstrong had the worst luck of his cycling career on Sunday when he crashed halfway through the 118-mile race over steep Alpine mountains to Morzine. He clipped a barricade while riding at about 40-miles-per-hour and slammed down on his back. The wind was knocked out of him. His teammates helped him up and they tried to catch the pack of main contenders. But it was not to be. The tough Texan bonked. It’s hard to recover from such a hard fall. In the end, Armstrong finished almost twelve minutes behind the big boys, and was left out of contention for an eighth Tour victory.
It was like watching Batman fall to the Joker. We want our super heroes to be invincible. In past years, a younger Armstrong could have regained super-human strength and caught up to the race leaders. But yesterday, he proved that he is only human, and a weakened one. I’m not foolish enough to think Armstrong, now almost 39-years-old, would win this Tour. But I didn’t expect to see him to retire from the world’s most prestigious cycling race in such a way. It isn’t fitting for a seven-time Tour de France champion to have such bad luck. But it happened. Before yesterday, Armstrong represented a rebellion to aging. He already conquered cancer. This year he was going to prove that somehow we can beat gravity and perhaps the inevitable. But reality has set in, and the road to glory has come to a dead end. Or has it? There are still two weeks left in the Tour. Armstrong has surprised us before. Perhaps he will win a stage or two. Bonne chance, Lance!


La Sagrada Familia In Barcelona Granted Building Permit After 137 Years
After 137 years, La Sagrada Familia basilica has finally been granted building permission by the city of Barcelona.
Work began on the Roman Catholic church, designed by Catalan architect Antoni Gaudi, in 1882, but it has never had official building approval.
City officials do not know why approval was never given. Records show a request was made in 1885 but there is no evidence of the permit being approved.
The Junta Constructora del Temple Expiatori de la Sagrada Família -- the foundation overseeing the building and preservation of the church -- agreed to pay €4.6 million (AU$7.45 million) in fees to negotiate the contract.
"This permission marks the conclusion of the proceedings initiated by the Junta Constructora with the goal of normalising the construction and finishing it in 2026," the foundation said in a statement.
The basilica, which was listed as a UNESCO World Heritage Site in 2005, has also been granted approval as a place of worship.
Janet Sanz, Barcelona's deputy mayor of urban planning said the agreement brings an end to "a historical anomaly in our city”.
"An income of €4.6 million to Barcelona, joining the €36 million agreed to compensate the impact it causes in its environment," Sanz said on Twitter.
"We are a brave government that does not allow privileges."
The building of La Sagrada Familia is funded by the 4.5 million people that visit it each year, as well as donations.
The building permit will cover construction until 2026 -- the year it is hoped to be finished, to coincide with the centenary of Gaudi's death.
Plaster models of Gaudi's plans are being used for the final stage of building, as the originals were destroyed in a fire in the 1930s.


Scientists Discover New Gentoo Penguin Colony in Antarctica
Photo: Arne Beruldsen
Scientists have discovered a newly established colony of 75 gentoo penguin chicks on little Andersson Island in Antarctica. It is the first documented gentoo migration to the archipelago, an unusually southern location for the breed.
Gentoo penguins are inclined to relatively temperate, ice-free zones. Until recently, conditions within Andersson Island’s latitudinal band were too icy for gentoo chicks. Similar migratory trends observed with other species suggest that the birds are responding to fast-rising global temperatures.
Antarctica and climate change
The Antarctic Peninsula is one of Earth’s most rapidly warming regions. Temps there have risen 3° C on average since the early 1970s. What may seem like a minor increase has already proven catastrophic for the area’s fauna and flora.
Elimination of livable terrain through industrial fishing, glacial calving, and rising sea levels, as well as the sweating-out of sensitive species, has resulted in monumental habitat losses and food chain disruptions. A recent expedition to Elephant Island found that chinstrap penguin colonies had collapsed by as much as 77% in 50 years.
Gentoo penguins as climate sentinels
Though research on Andersson Island’s fledgling penguin colony has just begun, experts say the reason for the bird’s uncharacteristic migration is apparent. The gentoo penguin was expelled from a region they’ve inhabited for millennia by a very sharp and fast uptick in atmospheric heat. The same warming effect also morphed an intractable polar region into a relatively hospitable landing for the flightless birds — at least for now.
The discovery has spurred renewed calls from the scientific community to establish a network for marine protected areas in Antarctica to help safeguard the region in the face of a rapidly changing climate.
“Penguins are a sentinel species and a great indicator of the health of the Antarctic ecosystem,” stated the expedition’s lead ecologist, Dr. Heather Lynch. “As expected, we’re finding gentoo penguins nearly everywhere we look –- more evidence that climate change is drastically changing the mix of species here on the Antarctic Peninsula.”


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What Music Video Is This Picture From?
There's not much more pathetic than a single man eating cold fried chicken from a tub, alone, in his kitchen. Believe it or not, the music video that this picture is from is a love song. The character shown here is acting out the role of what his life would be like as a single guy, had he not met the love of his life.
Don't think too far back to determine when you saw this music video. It was the first single from this singer's most recent album, and it turned into the biggest song of his career. Can you figure out which video this picture is from? Click the button below to find out and to see more country music video trivia questions.

domain: entertainment


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The neckbeard could be returning to Chicago.
Vaughn McClure of the Chicago Tribune reports that the Bears will attempt to claim Kyle Orton off waivers.
Actually, McClure said he was confirming Jay Glazer’s report. But Glazer never actually reported anything; he just said the Chiefs or Bears “could” claim Orton and it took a life of its own.
Let’s take McClure’s report at face value, though. We’re surprised Mike Martz would embrace the move, but it doesn’t mean the Bears will land Orton.
Waiver priority is decided by record, so the 7-3 Bears have to hope a lot of other teams pass. The Chiefs could claim Orton. Even teams like the Colts, Dolphins, or Redskins could try to kick the tires on Orton down the stretch.
We hope the Bears get him, if only because it’s a good story. Orton was never good enough for the Bears to fully get on board with, so they traded him in the Jay Cutler deal.
Now they want to ask Orton to help get the team back to the playoffs. So that Cutler can take over again.


Thornton Jr. Puts The Seal On Labor Day Weekend
Kevin Montgomery, PEORIA, Ariz. (September 5th, 2011) – Ricky Thornton Jr. made Labor Day seem effortless as he swept the holiday weekend double header by winning both 25-lap Total Seal Late Model feature events.
Thornton, aboard a second Joey Moriarty entry, started fourth in both Saturday and Sunday’s feature events making quick work to get the front and paced the remaining laps nearly unchallenged as he claimed his fourth Total Seal Late Model victory of the year matching the win total of Anthony Madrid.
Madrid would follow Thornton to the checker in Sunday nights feature while picking up a third place finish on Saturday and extending his point lead over Lonnie Parker Jr. while Thornton was able to gain ground on Parker. With the two wins Thornton tightens the chase for the championship which will be settled at Canyon Speedway’s Copper State 50 in mid November.
Jay Foster was among those with double feature wins this past weekend as he notched both days for IMCA Modified action and catapulted himself into the championship battle that will come down to the final race on September 17th.
Guy Norton, who picked up top three finishes both days, sits at the top of the standing with three points separating him and Jason Noll with Foster moving into position just six points behind Norton. A special race format will be announced for the championship season finale with the final round anticipated to be an astonishing finish to a very hard fought battle.
Matt Martinez also graced victory lane both nights has he swept the Western States Stock Car Series 20-lap features aboard Jesse Johnson’s ride. Both of Martinez’s wins came with a little controversy with late race contact with Jody Henderson for the lead on Saturday and a post race protest of Sunday’s win. The protest inspection requiring engine tear down exonerated Martinez and Johnson of any wrong doing giving the duo the Labor Day title.
George Fronsman and Daniel Romero continued the trend of back to back weekend wins as Fronsman took home the hardware for both Super Stock features with Romero sweeping Bomber Mania.
The PVR Mini Stocks made their first appearance at CSP with Bill Keeling and Bob Taylor picking up wins on Saturday and Sunday nights.
Full Results: http://www.canyonspeedwaypark.com/?page_id=8
The Super Fast ASCS Wing Sprint Cars will make their way back to Canyon Speedway Park for the first time in nearly two months. The ASCS2 Micors will join the field along with X-Mods and Dwarf Cars. The action kicks off Saturday night when general admission tickets go on sale at 5pm for only $15 for adults, Senior and Military $13 and CHILDREN 12 and UNDER are free. Racing will begin promptly at 7:30pm.
To keep up on all the latest news and happenings please sign up for Canyon Speedway E-News. The track update registration can be found at the top of the home page: www.canyonspeedwaypark.com
The full 2011 Canyon Speedway Schedule can be previewed online at: http://www.canyonspeedwaypark.com/?page_id=6
Canyon Speedway Park is located in North Peoria off Lake Pleasant Parkway, then 1.3 miles West on Carefree Highway. For more information please, contact the track at 602-258-RACE(7223) or additional information regarding Canyon Speedway Park can be found at www.canyonspeedwaypark.com


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Argentina is now cracking down on the climate terrorist by cutting welfare for those who block the streets. Santos says congress is insider trading. Biden says the economy is good. Gold and silver are being reclassified in many states.

domain: economics


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Pope Francis has arrived in Canada to embark on what he describes as a “penitential” trip aimed at reconciliation with Indigenous people for the Catholic Church’s role in residential schools.
The Pope told reporters on a plane before it landed in Edmonton on Sunday that the six-day visit must be handled with care.
The pontiff is also set to travel to Quebec City and Iqaluit.
“I hope, with God’s grace, that my penitential pilgrimage might contribute to the journey of reconciliation already undertaken. Please accompany me with .prayer,” said a message on the Pope’s Twitter account.
Francis was to be greeted at the Edmonton airport by Prime Minister Justin Trudeau and Gov. Gen. Mary Simon, as well as other church, Indigenous and political dignitaries.
He was next to travel to the St. Joseph Seminary, where he will be staying during the Alberta portion of the trip.
The Pope plans to visit the former Ermineskin Indian Residential School in the community of Maskwacis, south of Edmonton, on Monday. That is where Francis is to deliver his first public statement in Canada and is expected to apologize to Indigenous Peoples for abuses they have suffered.
An estimated 150,000 Indigenous children were forced to attend residential schools in Canada, where neglect and physical and sexual abuse were rampant. More than 60 per cent of the schools were run by the Catholic Church.
Treaty 6 Grand Chief George Arcand Jr. said survivors have been carrying unimaginable trauma for many generations. The Pope’s acknowledgment of their pain is a crucial step, he said.
“This is an important historical moment for survivors of the residential school system and the harm caused by the Catholic Church,” Arcand Jr. said last week.
On April 1, after meetings over several days with First Nations, Inuit and Metis groups at the Vatican, Francis apologized for the deplorable conduct of church members involved in residential schools and promised to visit Canada.
Indigenous delegates had told the Pope they wanted an apology on Canadian soil.
First Nations leaders in Alberta said they expect the Pope’s presence to open old wounds for Indigenous people and mental health counsellors will be at the sites. But they also hope the visit will be a step toward reconciliation.
“We are here with you and we are supporting you,” Louis Bull Tribe Chief Desmond Bull told survivors last week.
The Ermineskin school was one of the largest of the institutions in Canada. Organizers of the papal visit have said they expect about 15,000 people will be at Maskwacis to see the 85-year-old pontiff.
Later Monday, Francis is to meet parishioners of an inner-city church in Edmonton. A large outdoor mass at the city’s football stadium is scheduled for Tuesday. The Pope then heads to nearby Lac Ste. Anne to take part in an annual pilgrimage.
Francis is to travel Wednesday to Quebec City and deliver a public address following meetings with Trudeau and Simon. The following day another large mass is scheduled in Sainte-Anne-de-Beaupre.
The visit is set to finish Friday in Iqaluit before Francis heads back to the Vatican.
Organizers have said that due to the Pope’s age and physical limitations he will take part in public events for about an hour and will use a wheelchair throughout the tour.
Shortly after departing from Rome, the Pope used a cane to help him move around the airplane as he greeted individual reporters.
“I believe I can make it,” he joked.
Thousands have travelled from different parts of the country to take part in the events.
Mabel Brown, a 77-year-old residential school survivor, journeyed to Edmonton from Inuvik to hear the Pope apologize and find forgiveness and healing with other survivors. She hopes it’s an opportunity to move forward in a good way.
“This is a very important time in history,” she said. “Better things are yet to come.”
The Indian Residential Schools Resolution Health Support Program has a hotline to help residential school survivors and their relatives suffering trauma invoked by the recall of past abuse. The number is 1-866-925-4419.
This report by The Canadian Press was first published July 24, 2022.
View original article here Source


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Natural killer (NK) cells are innate lymphocytes that play a critical role in early host defense against viruses. Through their cytolytic capacity and generation of cytokines and chemokines, NK cells modulate the activity of other components of the innate and adaptive immune systems and have been implicated in the initiation or maintenance of autoimmune responses. This review focuses on recent research elucidating a potential immunoregulatory role for NK cells in T-cell and B-cell-mediated autoimmune disorders in humans, with a particular focus on multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematous. A better understanding of the contributions of NK cells to the development of autoimmunity may lead to novel therapeutic targets in these diseases.
|Journal||Arthritis Research and Therapy|
|State||Published - Jul 11 2013|

domain: literature


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This year’s Society of North American Goldsmiths’ (SNAG) conference “Meta-Mosaic“ was held in May in Toronto, Canada. It was co-chaired by Paul McClure of George Brown College and Melanie Egan of the Harbourfront Centre, an “innovative not-for-profit cultural organization that creates events and activities of excellence.”[i] The Harbourfront Centre boasts a metals studio in its own craft department hosting “six to seven full-time artists-in-residence”[ii] and runs a program of beginner and intermediate jewelry courses. George Brown College, a Toronto-based tertiary training facility prides themselves on preparing “workplace-ready graduates,”[iii] and as such, their jewelry course, a part of their School of Fashion Studies, offers “Jewelry programs [that] prepare you to work in the fine jewelry industry.”[iv] With the focus of the conference shaped by these organizers and organizations, it was an interesting year to go into the conference with an investigation topic already mapped—namely, how do the conference attendees articulate their relationship with skill?
The responses I received to my question varied, but all were arrayed along a fairly well defined spectrum. One end was an argument for a level of material knowledge and technical skill so high that these, and not an overarching design or concept, defined the output of the maker. This stance was best exemplified by a presentation on day two in the conversation between well-known Canadian maker and teacher Charles Lewton-Brain and Alan C. Elder. The artisan that came through this question and answer discussion was one clearly committed to material investigations, one for whom the process of metalsmithing is prized as both the means of conceiving and creating works.
Michael Belmore, another local artist, neatly encapsulated the other end of the spectrum in his presentation. He was the first to speak in the PechaKucha-style, midcareer artist talks. Dispensing with all but the sparest introduction, Belmore launched straight into a chronological presentation and examination of some recent works. He spoke conceptually and thematically about his finished pieces, and the ideas he was expressing through them. In some cases, he even touched on their life cycle and the audience reactions they garnered as well as on the intended or unintended consequences of their installation on a site or in a gallery. He mentioned his processes in passing, and in a perfectly aimed nod to his audience, made a joke about his large-format chasing work, saying that he resorted to repoussé only when he made a mistake, wryly undercutting the undeniably high level of skill displayed in his works. After this introduction (and despite some makers even claiming the contrary during their presentations) the dominance of craft terminology in the subsequent presentations was immediately noticeable. Process, materiality, and the studio were highlighted and conceptual content was often only given a glance.
It was clear from his presentation that Belmore learned and leveraged skills in service to his conceptual intent. In conversations with him after the conference, I sought further insight into his perceptions of the significance of skill within his practice, in which he stated that, “Skill is important. When things are done well, they seem effortless to the eye. Skill offers the easiest and possibly the best way to speak to the viewer … Skill is about capturing your voice in the object so that it can be shared easily.”[v] His materials and processes are planned in detail, as “they all have meaning, and they all talk to whatever issue I wish to imbue the object with.”[vi]
Freedom through Skill, Freedom from Skill
At this conference, my conversations with other artists, jewelers, object makers, and designers evinced a multiplicity of responses to the question of each maker’s relation with skill. Most of these conversations naturally veered toward matters of process and materiality, thus highlighting their importance to practitioners. This tendency illustrated the pervasiveness of craft thought amongst those in attendance.
The general consensus amongst my interviewees was that a base level of metalsmithing knowledge and skill is deemed necessary to create jewelry work. When noting to artist and writer Jillian Moore that this bias toward metals expertise came up time and again in my conversations, she said that “Some kind of expertise is what we are all interested in, and we have a traditional idea of what that expertise should be. There is a traditional model for training that kind of expertise that a lot of people work in.” When starting out, she mentioned that she found these traditional skills seductive, as it is easy to dazzle, to amaze, and to create wonder, and to produce a certain sense of opulence through the works so produced. For her practice now, however, she says “I’m interested in a different kind of wonder, so I take the patience that came with the traditional skillset and try to apply it to different things that give me the results that I want.”[vii]
For many of the artisans that I spoke to, the underlying assumption was that this level of skill is important in order to know how or when to acquire more skills. Then beyond that, there was often a higher expectation, where being well versed in a diverse range of skills was particularly prized. To summarize the words of educator and metalsmith Sean Macmillan, conceptual content is lent more legitimacy through skillful execution, when an artist understands the rules that they are breaking. In the same vein, Brian Ferrell likened metalsmithing to jazz, in that performers need to have a great understanding and skill in order to take their works in different directions.”[viii]
Interestingly, much of the work Savineau wore and all of the pieces she shared through the traditional SNAG first night pin swap were 3D printed. As a second-career artist, Savineau mentioned that she did not grow up with computers, but “is now pretty comfortable with them,” and that she had been introduced to 3D printing through SNAG conference attendance. She noted that part of the blessing of knowing, yet not having complete mastery of, this tool is that she enjoys the surprises she gets from the process. She acknowledges that with her limitations in computing skills, she is often party to accidental creative happenings, ones that would not have occurred if the process were completely in her control.[x]
Many makers made a case for the opposite, however, arguing for complete mastery of the skills used in their practice. Diane Reilly said this “allows you to express yourself fluidly with the material.” Reilly was also quick to point out that “skill and material aptitude allow you to be more fluid,”[xi] and to be “uninhibited by process.”[xii] A loss of inhibition in an effort to engage the subconscious, creative brain is understandably highly prized. In essence, that speaks to requiring a very high skill level, so as to cause the least amount of friction against burgeoning ideas.
And Skill Begat Skill
In the same conversation, Brian Ferrell, who began in metals but also creates furniture as well as being an educator, contributed that the “process of metalsmithing is so tangible … it allows you to explore new materials without prior knowledge.”[xiii] This idea, brought up time and again in my conversations, implies that owning a specific skill brings with it an implicit understanding of the limits and benefits of that skill in that material, and by proxy, a general understanding of similar processes in other materials. In effect, it begets a depth of understanding that can be engaged when cultivating skills in another arenas or when designing away from the workshop. It is a concept singled out by Juhani Pallasmaa in his book The Thinking Hand: “Mastering one craft helps the designer and architect to grasp the nuances of other crafts.”[xiv] This craft transference is seen as another important benefit of having what was often, and rather nebulously, described as ‘a base level of skill’.
In our conversation, Grace Hilliard-Koshinsky explained that while she had developed a repertoire of material knowledge, her intention for each piece she makes dictates the materials to be used and skills to be learned in order to create that work. In the course of developing new objects, she traces diverse ideas and thus works with diverse materials, and so at each turn she takes up the techniques required to resolve each as they dictate.
Hilliard-Koshinsky acknowledged that at the moment she is “pursuing steel,”[xv] and while she took pains to point out that she does not fit ideas to steel, she now “thinks” in steel owing to her creative immersion. In her view, having developed a mastery over this material—with it she is able to create hollow forms through the inflation techniques developed by mentor Elizabeth Brim—she now believes that she understands the implications of working in that material in a technical sense, according to its working materiality and more specifically why it works the way that is does.
This comment on the implications of steel precipitated further discussion on the wider ramifications of Hilliard-Koshinsky’s chosen material, and connected with a story from my past that involved experiencing how the massive iron ore trains in Port Hedland, Western Australia, have shaped that town geographically. This digression cast a new light on our use of the word “materiality.” The assumption that materiality and the implications of certain materials refers to their technical aspects and not to their historical nor cultural connotations seems to have been implied by the discussion of skill, as this was the only time this aspect of materiality came up in my discussions. It is possible that the word “skill” itself is loaded, especially for the group being interviewed, so its use consistently took these conversations in a particular direction.
Hilliard-Koshinsky uses this knowledge to her advantage to “wield it against type,” making realistic reproductions of soft things such as backpacks, duffel bags, and more recently, garments. Having these skills in her hands involves not only knowing how to create the object itself, but also having the skills needed to make the special tools required to fabricate the object. In effect, she leverages what knowledge she already has in order to analyze a problem and synthesize an entirely new solution in the form of a tool that did not exist before,[xvi] which can only be the product of skills she has already acquired. She says that these skills have thus allowed her to “develop a predictive sense, at least some of the time.”[xvii]
Katja Toporsky neatly described the non-binary philosophy espoused by many makers, stating that skills are both an important starting point and acquirable on an as-needed basis. “It’s important to have a wide array of skills at your fingertips. It then becomes choice rather than necessity to choose one skill over another.”[xviii] And then, “My work is also very experimental, involving a vast array of materials I had to explore and acquire the skills to work with. Here, skill is more related to knowledge about the material’s properties, its history, and the meaning people associate with it.”[xix]
Tellingly, Toporsky is in agreement with Belmore and Macmillan, in that she, too, recognizes that skill is not an end in itself, but by the same token, “lack of skill is a distraction and diminishes the work, so I do make sure things are executed to a good standard.”[xx] She also admits to finding comfort in working with what she knows, saying “I prefer to employ skills that I feel at ease with—die forming, chasing and repoussé, fabrication—over certain others.”[xxi] But she is also self aware, avoiding the perils of virtuosity for its own sake. “I sometimes choose not to learn a skill to perfection,” says Toporsky. “For example, I use a lot of molds into which I cast a large variety of materials. While I know how a perfect mold is supposed to be made, I prefer the look of the imperfect. Pure virtuosity without thought plays no role in work, and maybe that’s the place where I veer off the trodden path of craft.”[xxii]
Leaning away from virtuosity for its own sake was also noted in the group conversation that took place between myself and Maria Eife, Brian Ferrell, Jera Rose Petal Lodge, and Sean Macmillan. It turned out to be a watershed moment for me, for it was on this fateful occasion that I learned the expression “technical vomit piece.”[xxiii] This is pretty much as it reads—a piece that uses a lot of difficult techniques purely for the challenge of being able to execute them in concert. The group dismissed such works, noting that when the primary function of a piece becomes to impress other makers—and the consensus was that this was the main function of such works—then the object’s primary (and dubious) claim to fame is to limit its audience to people who would be impressed by such displays. Thus, while the conversation pointed toward the idea that skill is very important, it did include design and conceptual skill. The conclusion was that if the work has no center, no reason for being, it would ultimately be a weaker work than one that has put this skill in service to an interesting idea.
Shorthands and Parochialism
Of course in that conversation, as well in many others I was party to during the conference, the point is that technical skills are present. The unspoken assumption underpinning all of the informal interviews I conducted, as well as many of the presentations I attended, was that in order to be a “good” maker, skills in metalsmithing are of primary importance. And hand-in-hand with that, in order for the work to be good, the technical skills of the maker had to be evident in the work itself in some fashion.
That the conversations I had about skill referred to hand skills and metals training as the basis from which all jewelry and object-making (conceptual or otherwise) arrives, while unsurprising in itself, is more telling in what it reveals about makers, and perhaps the dominant educational paradigm, in North America, and more specifically, what artisans here are comfortable talking about. Inferred by and revealed through these conversations, and aided in the way in which language, and particularly the language of craft, was used during the conference presentations, it is possible to conclude that the practice of making itself is the most important thing that the collective is attempting to communicate about, and not the concepts illustrated or the ideas communicated through it. It would seem that the main concern within the field is not what or why, but how an object is made.
There is dissatisfaction with this being the state of discourse, as evident in my conversation with Maria Eife and Jillian Moore, two artists whose works benefit from a broader definition of skill. Both of these artists acknowledged that excellence in traditional craft skills are of more importance to their sensibility and ethos than they are to the practical day-to-day of their practices. For them, a well-crafted object is still part of the desired outcome. However, because their jewelry uses new materials (laser-cut felt and 3D-printed nylon in the case of Eife and hand-painted layers of resin over polymer or foam in the case of Moore), they are often considered the outliers in what I have come to understand is a metal-skills-focused field in the US. Eife also suggested the lack of visible trace of her hand in her work somehow makes her practice less acceptable in certain circles. This perception sometimes changes, however, when people find out about her metalsmithing education. Both artists would like to see a shift in focus from technique or materiality toward greater acknowledgment of conceptual skill, as it is in concept that Eife and Moore wish to define their works. They have made specific skill and material choices, yes, but they have been made very deliberately in service to the ideas that they are trying to convey through their works.
Having been in discussion with students about their works at the conference, Moore called into question the thematic shorthand that has crept into American craft through a desire or need to engage in (while perhaps not acquiring the skills to develop) a suitable conceptual dialogue around their output. In this shorthand, the use of certain materials and processes are tied to specific thematic associations, making it easy to append a meaning to the result of specific skill or material engagement in a work. An example is using a patina and automatically aligning the outcome with a dialogue about aging and decay. Moore laments that the dialogue around art jewelry will be limited to well-hashed territory, while makers continue to claim that their works are about something that “still reflects back to a process”[xxiv] rather than being driven by a broader and more self-aware discussion about the maker’s intent. Acceptance of shorthand themes as a reasonable conceptual discussion does not challenge the maker to wholeheartedly participate in the discussion. It is then easy to see how, in turn, this results in a lack of makers who are equally confident in their technical and conceptual skills, since their technical decisions are the only ones discussed (albeit through a pre-established thematic overlay.)
Yet, I found some discontent from the opposite direction, from those who feel that at the furthest reaches, conceptual jewelry has lost the connection with making skill, which if properly harnessed, would have the potential to make such works more powerful. This is a compelling argument, yet it conceals a willingness to dismiss the importance of developing conceptual skills at all, a prejudice which may have its roots in the skepticism of the idea that there is equal worth in conceptual and technical skills. When correlating the “wearable, stable, permanent”[xxv] jewelry with the other “temporary, open ended, changeable, ephemeral, a work-in-process”[xxvi] investigations, the technical skill level in this nonmaterial work (produced by fewer idea-driven makers) is found wanting, regardless of conceptual intent or quality. As Liesbeth den Besten also admits of this work in her book On Jewellery, “These character traits do not make it very easy to appreciate this work” and so these artists “breach the borders of their trade, yet at the same time, their work is rooted in their craft, its history, usage, codes, conventions, and bigotry.”[xxvii] The fact that they don’t engage with their craft skill is not true—sometimes, a judicious use of conceptual skill makes it necessary to exhibit its technical opposite—it is just that they choose to engage with it by not exhibiting only it.
Finally, despite the conference coordinators’ roles as educators of market-ready jewelers and craft-consumers, their efforts as curators did not result in any references to presentation and selling skills in my conversations. This was in evidence especially from the Canadian contingent of the early career artists who took to the stage on day three of the conference. There was significant reference to addressing the market in the presentation by Eric Peterson and to the importance of presentation to the collaborative works between Erin Wahed and Janis Kerman in their Bande des Quatres jewelry line. The dialogue that evolved around skill could, and perhaps should, have been more equally spread between all of the skills required to maintain a successful jewelry practice. Presumably, these skills include commercial (such as administration, communication, or brief fulfillment), conceptual, design, historical, making, (into which I incorporate technique and material manipulation abilities), professional, and research. Yet, it was making, and to a lesser extent conceptual skills, that dominated my interviews and conversations.
That making and conceptual skills butt up against one another so often in an either/or position rather than a more inclusive and/both position is revealing, as it seems that makers are set up (or being set up) to favor technical over conceptual skill. Perhaps the bias of the organizers was evident in the presentations and so did affect the dialogue that surrounded this year’s event. If that is true, whomever the SNAG conference organizers choose to shine a spotlight on is privileged to set more than just the agenda in their own presentation. Then again, perhaps it’s the opposite scenario— when choosing each maker to profile, the organizers are staying loyal to the heritage of their organization and the tastes of those perceived as the traditional attendees. Either way, for those in attendance at SNAG this year, the ownership of craft skill was considered noble, thus the speakers, presentations, and resultant dialogue seemed destined to reflect that fact.
[i] “Harbourfront Centre—About Us,” accessed May 28, 2013, http://www.harbourfrontcentre.com/whoweare/aboutus.cfm.
[ii] Harbourfront Centre, “Studios & Equipment | The Craft Department,” accessed June 13, 2013, http://www.harbourfrontcentre.com/craft/about/studios/.
[iii] “Mission Statement,” George Brown College, accessed May 28, 2013, http://www.georgebrown.ca/george_brown_college_mission_statement.aspx.
[iv] “School of Fashion Studies,” George Brown College, accessed May 28, 2013, http://www.georgebrown.ca/fashionstudies/.
[v] Michael Belmore to Melissa Cameron, “RE: I Make Stuff,” May 24, 2013,
[vii] Jillian Moore, interview.
[viii] Sean Macmillan et al., interview by Melissa Cameron, May 16, 2013.
[ix] Linda Savineau, interview by Melissa Cameron, May 16, 2013.
[xi] Dianne Reilly, interview by Melissa Cameron, May 17, 2013.
[xiv] Juhani Pallasmaa, The Thinking Hand, 1st ed. (Wiley, 2009).
[xv] Grace Hilliard-Koshinsky, interview by Melissa Cameron, May 15, 2013.
[xviii] Katja Toporski to Melissa Cameron, “Snag—THE Question!,” May 23, 2013,
[xxiii] Sean Macmillan et al., interview.
[xxiv] Jillian Moore, interview.
[xxv] Liesbeth den Besten, On Jewellery: A Compendium of International Contemporary Art Jewellery (Arnoldsche Verlagsanstalt, 2011).


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Listen to Chillin Wit Yo Girl (Prod by Skin and Bones), the latest track from YG, featuring Ty$. The cut dropped on Thursday, July 29th, 2010. YG's future brightens with every new release, and Chillin Wit Yo Girl (Prod by Skin and Bones) certainly isn't an exception. It's a fitting addition to a solid catalogue that YG has been developing since stepping foot in the game. We're excited to hear more.
Who else would you like to have seen on the track? Let us know what you think, folks.


The Oscar-winning actress asked her favorite reality star all the questions fans, including herself, have been dying to know. From farting in front of Kanye to OJ Simpson’s release from prison, the pair covered it all, but the first query was probably the biggest hurdle.
Straightaway asking, “do you think it’s a coincidence that Reggie Bush’s wife looks just like you?”
The night was filled with shockers, and amusing stories about their friendship.
At one point JLaw and Kim reminisce over their first encounter, where the actress screamed out “I love your show” to Kim across the lobby, as she was entering an elevator with Kanye. Later, the stand-in host recounted a more recent time where she had dinner with the reality star’s family at mom Kris Jenner’s home.
The dinner, “was everything [she] could’ve ever dreamed of” and she was five martinis in, when she wound up naked in the momager’s closet.
The reality star elaborates on the night saying: “So Jennifer came over for dinner two weeks ago, I’ve never seen my mom more drink in our lives. It was so funny. They had a few too many drinks for my taste.”
“I remember getting naked in your mom’s closet and ordering you to dress me. You dressed me fabulously, I looked amazing,” Jennifer added.
But just when rapper and fashion designer, Kanye West was about to add his expert touch, Jennifer took everything off.
“You said, I’m not joking I really want Kanye to style me and so I said, ‘Okay.’ I come back in and you’re fully butt naked,” the soon-to-be mom-of-three said.
Watch the video and let us know what you think about Kim's hilarious revelations!


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Drivers in Maryland now have two new reasons to opt for a plug-in electric vehicle
the next time go new car
shopping. Governor Martin O'Malley (above) has reportedly signed bills this week
that provide for car pool lane access for plug-in vehicles and a new $2,000 tax break. The High Occupancy Vehicle lane access is valid for three years starting this October for "qualified" vehicles equipped with a special permit. Buyers will also receive an instant $2,000 break on excise taxes at the time of purchase. Remember, the tax break is in addition to the Fed's existing $7,500 credit, so the cash is piling up for interested parties.
What remains unclear at this time is which vehicles will actually qualify for these new incentive programs. Presumably, all battery electric vehicles like the Tesla Roadster
, Nissan Leaf
, Ford Focus Electric
and ER-EVs like the Chevrolet Volt
qualify. It isn't yet known if plug-in hybrids
will qualify for these benefits, however.
| Image: Gail Burton/AP/Getty]


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NON-VIRAL GENE THERAPY FOR MUSCLE DISEASES
Myosana Therapeutics, Inc. is leading the efforts in developing new gene therapies that will slow skeletal muscle degeneration and heart failure to improve the quality of life, increase longevity and reduce the disease burden of Duchenne muscular dystrophy (DMD) and other neuromuscular diseases.
Duchenne muscular dystrophy (DMD) is a severe genetic disorder characterized by progressive muscle degeneration and consequent muscle weakness. As a recessive, X-linked condition, it almost exclusively affects males – with approximately 200,000 individuals affected worldwide. DMD starts to show its effects during early childhood. The boy’s motor functions rapidly deteriorate with disease progression and, by only 10 to 15 years of age, many boys with DMD are wheelchair-bound. Eventually the heart and breathing muscles are compromised, leading to a premature death from heart or respiratory failure.
Limitations of Viral Vectors
Currently, Gene Therapy for muscle diseases (skeletal & cardiac) has Significant Limitations;
Adeno-Associated Virus (AAV) is a common virus used to deliver "fragments" of healthy genes to the cells that contain unhealthy (mutated) genes.
AAV has a limited gene size capacity of 5 kilobases (kb), precluding its use for many larger genes. As an example, Dystrophin, the gene responsible for Duchenne muscular dystrophy (DMD) is 14 kb, meaning that only one-third of the dystrophin gene can be "packaged" into AAV. These ‘micro-dystrophins’ might provide only partial improvement of muscle function.
AAV is most often restricted to a single administration due to the likelihood of an immune response to the virus. Also, many people already have preexisting immunity to AAV, which may prevent them from ever receiving this gene therapy.
AAV is not specifically targeted to muscle, so high doses are required to achieve delivery throughout the body. This may lead to dangerous side effects.
It is difficult and costly to manufacture large quantities of AAV.
A Non-Viral Gene Delivery Platform
We have developed a Platform Technology with key features to address the problems posed by AAV administration;
Our technology does not use viruses to deliver genes to the cells.
A Non-Viral delivery method is much less likely to elicit an immune response, enabling repeated dosing over months or years.
We are able to directly target the muscle cells.
We have developed antibodies to a specific muscle protein, which binds to the cell and delivers the appropriate gene into skeletal & cardiac muscle. This unique technology has application to a wide range of genetic diseases affecting skeletal and/or cardiac muscle.
Importantly, our platform is Not Restricted By Gene Size.
Muscle-Targeted, Non-Viral Gene Delivery
Our Platform Technology consists of proprietary components that are designed to stabilize and effectively deliver full-length genes into muscles.
We have developed several monoclonal antibodies against a specific muscle target protein that is present in both skeletal and cardiac muscle.
We have developed other critical functions to ensure proper gene delivery. One component condenses the DNA of the gene and protects it from degradation. Another component provides stability in the circulation and assists in movement from blood vessels to the muscle. A third component provides a linking role that helps to deliver the DNA to the nucleus of the muscle cells.
MYOSANA THERAPEUTICS LEADERSHIP TEAM
Chief Executive Officer
Prof. of Neurology
University of Washington
NICK WHITEHEAD, Ph.D.
Founder & Chief Science Officer
Nick trained as a muscle physiologist and has more than 20 years experience in DMD muscle research. He is currently a Research Associate Professor in the Department of Physiology and Biophysics at the University of Washington. His innovative Muscle-Targeted, Non-Viral platform has the potential to provide a novel gene therapy treatment for DMD a wide-range of other neuromuscular and cardiac disorders.
Justin has decades of neuromuscular disease research & developed Biglycan as a potential therapy for DMD. He is currently the Scientific Founder and SAB Chairman of Bolden Therapeutics.
MONKEL LEK, Ph.D.
Assistant Prof. of Genetics
STAN FROEHNER, Ph.D.
James is an expert in CMC drug development, with decades of experience in the Pharmaceutical industry. He is currently providing CMC advice for Myosana.
Monkel is an established researcher in the neuromuscular disease field and his research has led to novel gene discoveries for previously undiagnosed rare muscle diseases.
MATTHEW LUMLEY, M.D, Ph.D.
Matthew is a trained Cardiologist with a Ph.D. in cardiovascular physiology. He has extensive experience in the Bio-pharmaceutical field, with positions at Pfizer, as Medical Director of Rare Diseases and, more recently Moderna, where he was responsible for taking the first mRNA therapeutics for rare diseases into the clinic. Currently, Matthew is a Venture Partner at Medicxi.
Founder & Chairman
Stan has decades of experience in muscle research and discovered the Syntrophin proteins, members of the Dystrophin complex in muscle. He has extensive research experience in DMD. He is currently a Professor of Physiology and Biophysics at the University of Washington. Stan was elected to the Washington State Academy of Sciences in 2013 and selected as a Fellow of the American Association for the Advancement of Sciences in 2017.
JEFF CHAMBERLAIN, Ph.D.
JAMES THOMPSON, Ph.D.
Head of CMC
Moderna Therapeutics (Retired)
SCIENTIFIC ADVISORY BOARD
Jeff is an internationally recognized leader in the gene therapy and muscular dystrophy fields and has been a pioneer in AAV micro-Dystrophin gene therapy research and clinical development for DMD.
Prof. of Medical Science

domain: health


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Update to RIA Library reading room services25 February 2022
Extension of opening hours beginning Monday, 28 February.
From Monday, 28 February the Library will open Monday-Thursday between 10am-1pm ; 2pm-5pm with up to eight readers per appointment slot. Readers will be required to wear face coverings in the library.
For more information please visit out Library Booking page.
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Penman for Monday, September 28, 2015
WE’VE BEEN talking about poetry in my Literature and Society class this past month, and it’s been an interesting journey, taking us everywhere from the Japanese haiku master Issa Kobayashi to the American modernist e. e. cummings and the Filipino early feminist Angela Manalang Gloria, with a bit of Sylvia Plath and Ricky de Ungria thrown in. There are many more important poets we could have taken up—in another class I might have discussed TS Eliot, Jose Garcia Villa, Denise Levertov, Edith Tiempo, and Pablo Neruda, among others—but this course is just a peek into poetry for non-Literature majors, so we’re taking examples that are sufficiently challenging and instructive but also fairly accessible, pieces that speak to common experience wherever in the world the poem may come from.
A few meetings ago we took up one of my personal favorites, a poem titled “The Blessing” (originally “A Blessing”) written by the late American poet James Wright in 1963. It’s not a very long poem, and pretty easy to visualize. As it opens, the persona (what we call the speaker in the poem, the “I”) is traveling on the road with a companion, bound for a city in Minnesota.
The mood is set with the descriptive line “Twilight bounds softly forth on the grass.” Two ponies emerge from the woods and greet the visitors. “They ripple tensely, they can hardly contain their happiness / That we have come. / They bow shyly as wet swans.” The persona feels a strong and strange attraction between himself and one of the ponies. “I would like to hold the slenderer one in my arms, / For she has walked over to me / And nuzzled my left hand.” The contact is electric, and the poem ends with the persona achieving a kind of apotheosis (a word I don’t use in class—let’s just say a climactic moment): “Suddenly I realize / That if I stepped out of my body I would break / Into blossom.”
It’s a lovely poem because of its consistency of tone and of its return to a Romanticism that seemed lost in an age of machines and pragmatism. (By Romanticism with the big R, we mean here an embrace of Nature as the source of all good things, and of the imagination over reason as the way to wisdom.) Indeed there’s a poignant optimism if not innocence in the poem that’s about to be shattered; in 1963, America stood on the verge of the Kennedy assassination and the escalation of the Vietnam War; the civil rights movement was rising to a crescendo. A darkening of the national mood—eventually affecting us half the world away—was imminent, if not inevitable.
That’s what I guide my students toward in the poem. It’s good to appreciate that glorious burst of ecstasy in the end, when the persona feels so in communion with Nature that he sees himself as a flower, but a couple of references earlier in the poem hint at another world—the “highway to Rochester, Minnesota” in the first line, and the “barbed wire” that the persona steps over to meet the ponies. Whatever “Rochester, Minnesota” might be (I’ve been to Minnesota but never to Rochester), it’s a city at the end of a long cross-country journey.
It’s the persona’s and his companion’s real destination, and the roadside encounter with the horses—as pleasant and as ennobling as it it—is just a stop. When the magical moment fades, the travelers will have to hit the road again, and lose themselves in the maw of the city.
At this point I pause to introduce a big word to my students, one of the few they’ll learn from me over the semester (as a rule, I hate big, showy words, and urge my students to do as much as they can with short, simple ones, but sometimes there’s nothing like a polysyllabic monster to wake people up). In this case, my word for the day was “prelapsarian,” referring to “the human state or time before the Fall,” in Christian belief.
The Christianity’s beside the point (we’re in UP, after all), but what’s important is the idea of a place of innocence we sometimes find ourselves wishing to go back to, especially when we feel overcome by the grime and the corruption of the modern world. We talk about the relationship (“dichotomy” would be another big word) between city and country, between a place we associate with sin and guile, and one we like to imagine as a refuge, a haven of peace and purity.
We then spend a bit of time on the image of the fence, which separates the road from the pasture. What are fences for, I ask? They keep some things out, and some things in, they’ll say. If Nature is as benign as the poem suggests, shouldn’t we knock all fences down? Let’s not be naïve, someone will say—not everything in Nature is so kind, and neither are many humans; we need to protect ourselves from each other. I bring in a quote from Robert Frost’s “Mending Wall”: “Good fences make good neighbors.” Do they, really?
We talk about the Pinoy penchant for building tall walls, topped by bubog and barbed wire, to ward off the presumptive manunungkit. Whatever happened to neighborly trust? We’re laughing, but when we go back to James Wright’s poem, everyone now understands why he gave it the title he did. Class is over, and we all step out to another late afrernoon in Diliman, finding our way home beneath the acacias and the bamboo.
PS / I don’t bring this up in class, because I don’t want “what really happened” muddling up anyone’s interpretation, but it’s interesting from a writing point of view to read what the poet Robert Bly noted down about a trip he took with his friend James (from the book James Wright: A Profile, quoted in english.illinois.edu):
“One day James and I were driving back to Minneapolis from a visit with Christina and Bill Duffy at their farm in Pine Island, Minnesota. Christina loved horses, had been a rider in Sweden, and continued to keep horses here. So horses were very much on both our minds. Just south of Rochester [Minnesota], James saw two ponies off to the left and said, “Let’s stop.” So we did, and climbed over the fence toward them. We stayed only a few minutes, but they glowed in the dusk, and we could see it. On the way to Minneapolis James wrote in his small spiral notebook the poem he later called ‘A Blessing.’”
[Image from mcleodcreek.farm.com]


Italian architect Renzo Piano has unveiled its high-rise glass tower named ”555 Howard” in San Francisco developed in collaboration with local design firm Mark Cavagnero Associates.
The project will be the first US tower from Piano outside of New York and features vegetation on its top level.
It takes the form of a clear glass tower featuring a hotel, along with residential space, meeting rooms, a ballroom, a gym, a restaurant and a public cafe on the ground floor, with an open rooftop terrace situated atop 36 floors.
In the flying terrace, a penthouse restaurant and lounge are shaded by trees and framed by a 20-foot-high glass wall.
A 12-metre-tall tower uses double layers of glass along the south and west side to lower heat inside the building, while solar panels could also be integrated.
The project was presented at the city’s Planning Commission last week and it is expected to be approved within a month.
Renzo Piano is also one of the finalists for the Qatar Art Mill regeneration project, a competition to transform a former flour mill in Doha into an art gallery.


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The Student Attitude Survey
Full Metadata Record
AbstractPolitical attitudes and college political conduct of American students. Topics: Attributes of an ideal professor and image of the professorsat the college; contacts and communication with college instructors;self-image of students; evaluation of study conditions, education,research, instruction, mass operation and academic freedom at theuniversity; most important goals of university education; reasons forthe choice of the university city; assessment of the need for reform ofAmerican society; most important problems of the university; promotionof creative and critical thinking of students by professors; evaluationof appropriate methods of student protest; sympathy for the studentdemonstrations at the Berkeley University; personal politicalactivities and willingness to participate in demonstrations; attitudeto the civil rights movement, the Vietnam war, sexuality, the churchand the government; judgement on the effect of political protestagainst the Vietnam war; perceived deceptions among students; diversescales: among others satisfaction with studies, dogmatism anddemocracy; judgement on the student newspaper; length of studies; dailystudy time; performance certificates; average grade; occupational goal;working student; political orientation and change in attitude sincestart of studies; membership in college political groups; socialorigins and influence of parents on the decision for studies; contactwith parents and political discussions; party preference of parents;media usage. Demography: age (classified); sex; race; marital status; familycomposition; number of children; religious denomination; religiousness;household income; housing situation; regional origins; military service.
Allerbeck, Klaus R.: Soziale Bedingungen für studentischen Radikalismus: Eine vergleichende Untersuchung in der Bundesrepublik Deutschland und den Vereinigten Staaten. Köln, Wirtschafts- und Sozialwissenschaftliche Fakultät, Diss. 1971.
Allerbeck, Klaus R.: Soziologie radikaler Studentenbewegungen: Eine vergleichende Untersuchung in der Bundesrepublik und den Vereinigten Staaten. München: Oldenbourg 1973.
Update Metadata: 2022-05-17 | Issue Number: 102 | Registration Date: 2010-07-21

domain: politics


text:
Sometimes, chart authors get creative. Maybe they think their chart needs more visual interest. Or maybe they think extra colors will appeal to the audience. This can be misleading. So use color carefully.
Important: Don't use different colors for different bars unless there's a good reason to.
Color, like bar length, can provide some information about the data. If you want to highlight a trend in one category, you can color that bar and make it stand out. But don't make the mistake of thinking that color is decoration. Bar color can be read as information.
You can add visual appeal by choosing one pleasant color for the columns, but there's no need for each bar to have its own color. The category axis will describe each variable by name; you don't need to describe it with a color.
Nevertheless, when you want to point out interesting or untypical categories, go ahead and use another color. Use color like you would highlight text in a document.

domain: design


text:
Lanzarote is a novella by the French author Michel Houellebecq, published in France in from a draft written at an unspecified earlier time. Pedro Blas Gonzalez Lanzarote – Michel Houellebecq See all books by Michel Houellebecq at | Lanzarote is a. A review, and links to other information about and reviews of Lanzarote by Michel Houellebecq.
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Apr 18, Lee rated it liked it. His lsnzarote on supposed national lanazrote of European holidaymakers is funny, but since then the Euro has been created and doing well despite several crises and several EU enlargements some questionable have taken place.
This is a very short book – barely even novella length. Houellebecq took this as a positive sign, believing the emphasis these guides place on “intelligent” and eco-friendly tourism “have succeeded in redefining international standards of stupidity”.
Dust to dust
On Lanzarote, one can meet some fascinating human specimens, notably Pam lanzarotee Barbara kanzarote ‘non-exclusive’ German lesbians – who can give rise to some interesting combinations. Realising that his New Year is probably going to be a disaster, as usual, our narrator, on impulse, walks into a travel agency to book a week in the sun. In short, he offers nothing very different to, say, the late Auberon Waugh.
Houellebecq counters airy intellectualism with a mordant common sense.
Aug lanzafote, Carlos rated it really liked it. Then there are also the Azraelians, a cult that believes humans were created in a laboratory by an alien i.
Lanzarote is a compact little novella which has it all. Lovecraft, he brought out his first novel Extension du domaine de la lutte in The silence was absolute. Aug 01, Sergio D.
On Lanzarote, one can meet some fascinating h Realising that his New Year is probably going to be a disaster, as usual, our narrator, on impulse, walks into a travel agency to book a week in the sun.
Oct 29, Anna rated it liked it Shelves: Amazon Advertising Find, attract, and houeloebecq customers. This desolate landscape most of the eight colour photographs included with the text look like they lanzaarote have been taken on the moon or Mars attracts a “nebulous variety of tourists”, and it’s as lanzarpte a place as any for him.
I came because I came here last year. Lanzarote is an odd little exotic-trip account. Published June 3rd by Vintage first published It’s not until Rudi’s letter and the subsequent news of the Azraelites that the book’s point seems to take form.
Lanzarote (novel) – Wikipedia
Stories of a houellebecs, sexual escapades and unfulfilled characters abound. Like Telegraph Books on Facebook. Paperback87 pages. There’s some sight-seeing, some frolicking on the beach, some sex-play. I swear… Houellebecq is respected in France but not loved. Sep 17, Doroti rated it liked it. It’s still worth a read since I couldn’t have spent more than an hour reading it. Books by Michel Houellebecq.
Or will he join the ‘azraelian’ sect, as they houellebeecq for humanity to be regenerated by extra-terrestrials? This is a short novella from87 pages in the edition I had by Houellebecq written before The Possibility of an Islandbut which is very much linked to the later book.
Jun 30, Robert rated it it was ok.
Lanzarote – Michel Houellebecq
Will they succeed in seducing Rudi, the police inspector from Luxembourg, currently living in exile in Brussels. If you are a seller for this product, would you like to suggest updates through seller support?
English Choose a language for shopping. Sep 06, Caterina Pierre rated it it was amazing. There seemed to be certain syntactical and grammatical errors in the text which really bothered me. In the early evening, after a short trip to the beach, he is to be found drinking bizarre cocktails.
Lanarote narrative is fully developed, funny as hell, and poignant houwllebecq its examination of a man searching for some sense in his own experience. Reads entirely unlike fiction, but a google search for “Azraelian” made me feel like a duped fool.
The Englishman goes to a particular tourist destination purely because he certain that the will meet other Englishmen there.
As for our narrator, will he consider his week’s holiday on the island a success? Houellebecq is more extreme because he is further out on a limb, and further along the road of self-hatred and despair.
Fiction Michel Houellebecq reviews. Houellebecq’s three novels to date have delighted in ridiculing this dream, arguing that a world that liberates human desires is far too complex to be understood by the human mind.
In between he manages to add in some Islamophobia and stuff about the Hoellebecq paedophile scandal of the late nineties for good measure.
After a disastrous publicity tour for this book, which led to his being taken to court for inciting racial hatred, he went hhouellebecq Ireland to write. The mermaid alludes to the pair of female German bisexual nudists with whom the French narrator flatly describes, lick-by-suck-by-groan, his wishful-seeming orgy on a beach – yes, Houellebecq once again pays his dues to medium porn and to Bergman’s Persona.
Follow the Author
As usual, disturbing but great. He opposes the wilder forms of permissiveness with his own honest, self-deprecating libertarianism. I would still say that I enjoyed most of this and it is a worthwhile read, but it does read like it has been rushed and unfinished. The Azraelian sect is presumably based on the real-life Raelians whose claim to have cloned a human being was the subject of much heated debate earlier this year. Un libro muy divertido de Houellebecq, como si a Plataforma le quitaran mucha de la paja que le sobra.


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Hello there, Christine here with a shaped shaker card using the Summertime Sips die set to create a super fruity lemon strawberry smoothie. I used the Slimline Space Swirl 6×9 3 piece stencil to create the fruity concoction and a cute little unicorn from the Let The Good Times Roll stamp & die set to finish it off!
Let’s start with the shaped card base. I folded an 11 inch by 4.25 inch of heavy cardstock (Neenah solar white 110 lb cardstock) in half and placed the top part of the drink container slightly off the top of the card as seen below (teal arrow). I did partial die cutting and cut only up to the bottom edge.
Then I placed the bottom part of the drink container and only die cut up to the teal arrow (again do partial die cutting). I had to fussy cut part of the card base so it fit with the actual pieces of the drink that I glued on top.
Then I die cut one large drink piece out of light yellow vellum and ink blended kitsch flamingo and spun sugar distress oxide inks onto it with the Slimline Space Swirl stencil as shown below. You have to go over the areas multiple times to make it smooth and seemless.
I die cut a straw and the drink components multiple times out of acetate, blue vellum and cardstock to create the shaker component of the card. I added a few strawberry embellishments and some ice cubes die cut out of regular vellum and then closed up the shaker component with a large acetate piece.
Finally I added the unicorn that I die cut from the Let The Good Times Roll stamp & die (colored with W0, W3, R20, BG11 and Y23 copics) with a little glitter paste on the horn at the top and a hello die cut from the Hello Bootiful die set (also painted with glitter on top) to finish the card off.
Thank you so much for stopping by!


Regional Technical Committee
1. Call to Order – Chairman’s Comments
2. Deputy Executive Director’s Report
3. Public Comments on Agenda and Non-Agenda Items
4. Highlights of the September 7, 2021 RTC Meeting
5. Proposed Calendar Year 2022 Regional Technical Committee (RTC) Meeting Dates
6. All Aboard Atlantic Avenue
Staff will share details and photos from DVRPC's Expo: Experimental Pop-up project in Collingswood, NJ. This summer DVRPC, Collingwood Borough, Camden County and Cross County Connections TMA teamed up to design and execute a pop-up streetscape project along Atlantic Avenue in Collingswood. The project included the region's first Advisory Bicycle lane as well as pedestrian improvements at several intersections aimed at improving bicycle and pedestrian connections to the Collingswood PATCO station, the Collingswood farmers market, and many other nearby destinations.
7. Updates and call to actions from the Public Participation Task Force (PPTF)
The mission of the Task Force is to provide ongoing access to the region’s planning process and empower resident involvement. Members are given a platform to learn more about upcoming projects, provide feedback on planning practices, and test out public outreach strategies. This presentation will cover the PPTF's recent activities, including the ideas generated at the Work Program workshop, and provide resources for planning partners to aid in application outreach. Applications are due by December 19th, 2021 and can be found online here: http://www.dvrpc.org/GetInvolved/PPTFApplication/.
8. NJDCA Statewide Model Municipal EV Ordinance
The NJDCA Statewide Model Municipal EV Ordinance was released by NJDCA on September 1 in compliance with P.L. 2021, c. 171, which Governor Phil Murphy signed into law on July 9, 2021, and requires that Electric Vehicle Supply/Service Equipment (EVSE) and Make-Ready parking spaces be designated as a permitted accessory use in all zoning or use districts and establishes associated installation and parking requirements related to EVSE in New Jersey’s 565 municipalities.
9. What’s In Store: Exploring the Future of Shopping Malls in Greater Philadelphia
Increased online competition, evolving consumer preferences, and, more recently, the COVID-19 pandemic have contributed to the decline of enclosed shopping malls. Although many of these properties may no longer support a traditional mall, they are often strong candidates for redevelopment. This report summarizes research designed to help communities throughout Greater Philadelphia better understand the challenges and opportunities created by struggling or vacant mall properties special event planning, and more.
10. Sidewalk Priorities in Montgomery County
Aaron Fraint and Logan Axelson (DVRPC) along with Anne Leavitt-Gruberger (MCPC), will introduce a new map tool that helps communities in Montgomery County analyze their sidewalk networks and prioritize the most important gaps for pedestrians. The tool allows local planners to learn how to evaluate the sidewalk connectivity of key destinations in their communities—like schools, health care facilities, libraries, and more—and identify which sidewalk gaps would most improve pedestrian connectivity.
11. Water Table
The Water Table initiative was funded by the William Penn Foundation with the goal to bring nonprofit conservation organizations, the water-user community, and government agencies together to build relationships and collaborative initiatives for better alignment of efforts, new projects, and possibly new sources of funding. DVRPC staff will report on this 15 month project.
12. Work Program Development Update
13. One Minute Reports
RTC Members and guests will be invited to provide updates on the activities of their agencies.
14. Old Business and New Business
15. Meeting Adjournment
The next scheduled meeting of the RTC is Tuesday, November 9, 2021.


Alternative migraine cures
by DR JOHN BRIFFA, Daily Mail
Migraines affect almost one in five women and six per cent of men. Some attacks may lead to severe symptoms such as intense, throbbing pain, nausea, vomiting and diarrhoea.
Migraines clearly represent a significant public health problem, and it comes as no surprise that painkilling medication, both over-the-counter and prescribed, are the mainstay of treatment.
But addressing the likely underlying causes, while gradually withdrawing from medication, is usually the key to controlling migraine.
Natural medicine offers a number of strategies which can be very effective in controlling and even eradicating migraine attacks. A major cause of migraine is food sensitivity. Certain foods are known to trigger migraine.
Sometimes referred to as 'the five Cs', these are: chocolate, cheese, claret (and other red wines), coffee (and other sources of caffeine) and citrus fruits.
Other research suggests the most common food trigger is actually wheat and that milk and eggs are other tiggers.
Migraine can sometimes be triggered if the level of sugar in the bloodstream gets too low. This may be the cause in individuals who can wake up with a headache or be prone to an attack if they skip a meal.
To ensure a stable level of blood sugar, regular meals and snacks should be eaten, and the diet should be based around fresh fruits and vegetables, meat, fish, and whole-grain starches such as wholemeal bread, wholewheat pasta and brown rice.
A common and often overlooked cause of migraine and other headaches is dehydration. Many people find that just drinking from one-and-half to two litres of water a day can lead to a substantial improvement.
Migraines can sometimes also be related to nutritional deficiency. One of the most important nutrients in this respect is magnesium. I generally recommend that migraine sufferers take 200-250mg of magnesium once or twice a day.
Another natural remedy which can often be effective in the prevention and treatment of migraine is the herb fever-few (tanacetum parthenium).The daily recommended dose of parthenolide is 250mg a day.
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text:
Coffee makes people crave baked goods, just as baked goods make people crave justice. Take a bite out of sweet, crumbly crime with this Groupon.
- $12 for three Groupons, each good for $7 worth of cafe fare on separate visits ($21 value)
The Weekday Cafe
Who said Saturday and Sunday are the best days of the week? The Weekday Cafe may just change a few opinions where that's concerned—its doors are only open Monday through Friday, from 7:30 a.m. to 2:30 p.m. But the schedule restrictions ends there: breakfast is served from open to close, so guests can start their mornings or afternoons with options ranging from egg and cheese burritos to quiche du jour.
As lunchtime rolls around, the menu expands to include myriad salad and sandwich options, such as romaine lettuce tossed with apple chips and walnuts or a hot kaiser roll stuffed with seasoned chicken, and topped with cheddar cheese and house-made BBQ sauce. Steamy cups of New England Coffee complement the cuisine, which visitors can savor as they enjoy free Wi-Fi in the cozy lounge or watch for UFOs on the outside patio.

domain: food


text:
The influence of scald water pH on the death rates of Salmonella typhimurium and other bacteria attached to chicken skin.
- Published Article
The Journal of applied bacteriology
- Publication Date
Oct 01, 1984
Factory trials where scald tank water was maintained at pH 9.0 +/- 0.2 showed that compared with the usual system of scalding when the water is at pH 6.0 for much of the working day the bacterial counts on carcases post scalding and plucking were significantly lower. In laboratory experiments, attached Salmonella typhimurium and the naturally occurring skin flora were found to be killed significantly more quickly in water at pH 9.0 +/- 0.2.
Report this publication
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
This record was last updated on 07/01/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/6389467


text:
At a time of year when Prince Edward Island farmers would normally be flat-out busy, most of their equipment is sitting idle as they wait for a break in the weather.
Harris Callaghan, a potato grower from Miminegash, estimated spring planting in western P.E.I. is already at least a week behind schedule, and if the weather doesn’t soon turn, they’ll be two weeks behind. He’s already eyeing a sunny forecast for Thursday; hopeful of getting on some of his drier fields before the end of the week.
Production is already lagging a little behind 2018, Callaghan said, pointing out farmers contended with a late spring last year, too. “It’s a risky business. You take chances. Sometimes you win and sometimes you lose. That’s the way it is, and there’s no point complaining about it."
“It’s getting frustrating,” said P.E.I. Potato Board general manager Greg Donald, who is all too familiar with last year’s growing season which got off to a late start and then felt the effects of drought-like conditions, followed by an extremely soggy harvesting period and early frost. As a result, Donald said, over 7,000 acres out of a total P.E.I. crop of 86,000 acres, went unharvested. That’s in addition to a high cull rate for small and mis-shaped potatoes.
“The stakes are high,” Donald said, pointing out the production cost is more than $3,000 per acre. “There’s lots of hardship after last year.”
While conditions looked favourable at the start of the month, with optimism for a normal planting season, conditions have turned wet and cold. Donald estimates fewer than five per cent of the 2019 crop is in the ground, and he said fewer than 100 acres have been planted west of Portage.
The rainy and cool weather has also been bad for Nova Scotia farmers. The lack of sun and warmth and the excess of rain is causing havoc for farmers who need to get crops in the ground as well as those who have already sown the fields. Some say the weather has set them back up to four weeks.
Philip Keddy, of Charles Keddy Farms in Kings County, who is also president of Horticulture Nova Scotia, said he has two or three days left to get strawberry plants in the ground for them to be ready to be dug up and shipped to Florida on Sept. 20.
“Normally we’d be done two weeks ago,” he said. “I don’t have time to wait. They have to grow every single day until they’re harvested,” he said Tuesday. “Every day like today I’m losing yield. I have a window [for harvesting to ship south] that I have to follow no matter what.”
He said he harrowed a piece of land Saturday night until 11 p.m. to get it ready for planting the next day, “and by Sunday night when they were finishing, it was raining again. We’re just getting these short little windows of opportunity.”

domain: agronomy


VIDEO: Woody Harrelson and Kevin Costner Take on Bonnie and Clyde in ‘The Highwayman’ Trailer
Actors star as two real-life Texas Rangers in Netflix’s 1930s-set crime dramaFebruary 21, 2019
“True Detective” star and repeat Stern Show guest Woody Harrelson partners up with Kevin Costner to catch a different kind of criminal in Netflix’s upcoming crime drama “The Highwaymen.”
The actors play Maney Gault (Harrelson) and Frank Hamer (Costner), the real-life Texas Rangers who teamed up to take down Bonnie Parker and Clyde Barrow in the 1930s.
The film is set at the height of the notorious duo’s violent crime spree. The public has demanded answers and Texas’s first female governor, Miriam “Ma” Ferguson (Kathy Bates), promises them her best and brightest cops are on the case. “We will capture them,” she tells a reporter. “Write that down and underline it twice.”
That proves easier said than done, however, and the only men capable of tracking down the outlaws are Costner and Harrelson’s Rangers, portrayed as old-school cowboys a bit out of their element in a world of gangsters and machine guns. The trailer (above) shows them following a trail of fresh corpses as they zero in on Bonnie and Clyde’s whereabouts, but the bad guys grow more popular with each passing crime and soon it’s hard to tell who the public is rooting for.
“You’ve come to the wrong place mister,” one man tells them. “Around here, Clyde is king.”
“Clyde might be king, but I’m a Texas Ranger you little shit,” Woody responds.
“The Highwaymen” debuts March 29 on Netflix.


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text:
In 2023, the United Arab Emirates’ real estate market saw a remarkable surge, reaching a total of AED 455.7 billion in sales, significantly driven by Dubai’s dynamic off-plan sector. This sector has shown continuous growth over the past four years and is expected to fuel the market’s expansion in 2024 and beyond.
Madhav Dhar, COO and co-founder of Zazen Properties, highlights that despite the introduction of over 60,000 new units, demand in Dubai still surpasses supply. This is attributed to the rapid population growth, placing Dubai among the top globally in this respect.
Dubai’s thriving tourism industry played a crucial role in 2023, boosting housing demand. The city saw a sales value of AED 160.46 billion, marking a 72.3% increase from the previous year. Additionally, off-plan sales transactions reached a record high of 68,783 in 2023, a 59.4% increase from 2022.
Dhar also pointed out the significant impact of the UAE’s decision to remove the AED 1 million down payment requirement for the golden visa programme. This change is expected to attract more investors, enhancing Dubai’s real estate landscape by making it more accessible as a secondary or primary residence. This policy is seen as a testament to the UAE’s commitment to fostering a resilient and innovative real estate sector, paving the way for sustainable growth and new opportunities.
Experts in the industry have noted the potential influx of investors due to the eased requirements for obtaining a golden visa. This move is anticipated to not only boost the UAE’s economy but also significantly enhance the value of its real estate sector, encouraging developers to accelerate their project construction.
In the third quarter of 2023, off-plan properties dominated Dubai’s property sales, accounting for 65% of the total sales value, which stood at AED 13.62 billion. Analysts attribute this rebound in the off-plan market to strong government initiatives and increasing investor interest, with new technologies like virtual reality tours and blockchain enhancing transparency and efficiency.
The current trend of rising mortgage rates has shifted the focus towards off-plan investments. Higher rental yields offset the increasing costs of mortgages, making off-plan properties a more favorable economic choice. These investments allow for original pricing and flexible payment plans, making them more adaptable financially. Dubai’s population growth further bolsters this demand, making it an opportune time for investment in the off-plan market.
Original article reference: Zawya.

domain: geography


text:
Another study from van Campen, Rowe, and Visser!
Compression Stockings Improve Cardiac Output and Cerebral Blood Flow during Tilt Testing in ME/CFS (van Campen et al., 2021)
Without compression stockings, patients experienced a 25% drop...
Background and Objectives: Symptoms and hemodynamic findings during orthostatic stress have been reported in both long-haul COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), but little work has directly compared patients from these two groups. To investigate the...
Orthostatic intolerance: POTS, hypotension and more. Webinar with professor Peter Rowe 19.10.21
Peter Rowe talks about the different types of orthostatic intolerance, and about how to manage and treat OI.
Authors: Sarah K Vogel, Isabelle R Primavera, Colleen L Marden, Samantha E Jasion, Erica M Cranston, Marissa A K Flaherty, Richard L Violand, Peter C Rowe
Published: September 16, 2021
The Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients with Joint Hypermobility Show Larger Cerebral Blood Flow Reductions during Orthostatic Stress Testing Than Patients without Hypermobility: A Case Control Study
Hypermobility in ME/CFS: effect on cerebral blood flow (van Campen...
Deconditioning does not explain orthostatic intolerance in ME/CFS (van Campen, Rowe, and Visser, 2021)
I thought the title statement should have been obvious to people by now, but apparently not...
A new publication from Van Campen, Rowe, and Visser on the effect of sitting up in severe ME:
Earlier this year they published a similar study on the effect of tilting the head in severe ME...
Cerebral Blood Flow Is Reduced in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients During Mild Orthostatic Stress Testing: An Exploratory Study at 20 Degrees of Head-Up Tilt Testing
C Linda M C van Campen 1 , Peter C Rowe...

domain: medical