|Publication number||US7660561 B2|
|Application number||US 10/769,690|
|Publication date||Feb 9, 2010|
|Filing date||Jan 2, 2004|
|Priority date||Mar 8, 2002|
|Also published as||CA2478312A1, CN1639988A, DE60313443D1, DE60313443T2, EP1488532A2, EP1488532A4, EP1488532B1, US6714769, US20030171099, US20040156458, WO2003077356A2, WO2003077356A3|
|Publication number||10769690, 769690, US 7660561 B2, US 7660561B2, US-B2-7660561, US7660561 B2, US7660561B2|
|Inventors||Leonid Kazakevich, Gerard Klahn, Fatih Ozluturk|
|Original Assignee||Interdigital Technology Corporation|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (17), Classifications (13), Legal Events (2)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This application is a divisional application of U.S. application Ser. No. 10/328,663 filed on Dec. 23, 2002, which claims priority from U.S. provisional application No. 60/363,051 filed on Mar. 8, 2002, which are incorporated by reference as if fully set forth.
The present invention relates to wireless technology. More particularly, the present invention relates to the field of smart antennas and diversity techniques for improving the quality of the transmitted and/or received communication to facilitate selection of the better quality signal.
Transmitters and receivers of wireless systems typically employ a single antenna which may be preferred from a cost viewpoint. However, multiple antenna arrays have also been employed which have been found to provide certain cost/benefit features. It is nevertheless highly desirable to provide a capability of selecting the antenna receiving (or in the alternative transmitting) the signal having the best quality.
The present invention is characterized by providing techniques and apparatus including a channel estimator for monitoring signals received by each antenna in a multi-antenna array to determine signal quality, and to select the better quality signal for processing. Monitoring of signal quality continues throughout the reception period in order to provide the capability of altering the selection of the signal chosen for processing whenever such a change is again warranted. Some of the techniques described herein are usable for both uplink and downlink applications.
The following figures are useful in describing the techniques and apparatus embodying the principles of the present invention in which like elements are designated by like numerals and, wherein:
In the example shown in
Circuits 24 and 26 respectively provide the support signals for the incoming signals and are driven by source 28 which in the example given, operates at 240 kHz. The signals from mixers 20, 22 are combined at 30 to provide the possible outputs as shown. The outputs are then sent to a single receiver for further processing.
It should be noted that the antennas employed may be similar to one another and placed at different locations or may be of different designs. The resulting signals are compared to determine their quality and selected to obtain the best quality signal. Also, more than two antennas may be employed.
As an initial operation, the output signal is coupled to monitoring device 36, shown in
Assuming that the frame or slot of each of the signals A and B being examined indicate that the quality of the signal A is superior to that of the signal B, as a result, the monitoring means 36 operates switch means 34 in such a manner as to receive three units (i.e. time slots, frames, etc.) of signal A in succession and thereafter switch to antenna 14 to receive one unit of signal B, and thereafter repeating this pattern. Throughout this signal selection, the monitoring circuit 36 continues to monitor the slots/frames of each signal A and B and, in the event that there is a change in signal quality, whereupon the quality of signal B is superior to that of signal A, monitoring means 36 operates switch means 34 so as to couple a greater number of consecutive units of signal B to the output utilization device and thereafter a lesser number of consecutive units of signal A, repeating this pattern until another change in signal quality occurs between the signals A and B. Again, it should be noted that monitoring of signals A and B continues throughout the reception period (or transmission) to continually ascertain the quality of the signals A and B and to alter the weighting of the intervals per antenna coupled to the receiver.
Although the example given shows a 3-to-1 ratio of signal reception intervals favoring signal A as shown by waveform 38 b or favoring signal B, shown by waveform 38 c, it should be understood that other weightings may be selected and such weightings may be selected as a function of relative quality. For example, one relative quality level may warrant a 4-to-1 ratio, a lower relative quality level may warrant a 3-to-1 ratio, a still lower quality level may warrant a 2-to-1 ratio, and so forth. The antennas 12 and 14 employed may be similar in design and distinguished merely by physical location; or may be antennas of different designs. For example, both antennas may be omni-directional, one antenna may be omni-directional and the other have a highly directional radiation pattern, and so forth. Each antenna may alternatively be an antenna array, the arrays having different directivity patterns, similar directivity patterns but with dissimilar orientations, and so forth.
The number of antennas switched may be greater in number than two. However, monitoring and comparison of the A and B signals and another signal or signals continues regardless of the priority given, whereupon a change in signal quality as between the signals monitored will cause an appropriate change in the priority. It should be noted that when signal quality as between the monitored signals is equal, an alternating pattern as shown by waveform 38 a is obtained. Equality may be provided employing other patterns as well. For example, two intervals or frames of signal A may alternate with two intervals or frames of signal B.
The arrangement of the embodiment shown in
The same technique may be used for uplink application, especially for time division duplex (TDD) systems. Since uplink and downlink channels are reciprocal in TDD, once signal quality is measured at each antenna, this information is utilized to decide which antenna is given priority and in a similar fashion to that of the reception application, a transmitter transmits multiple units from one antenna and another different number of units from the other antenna based on comparison of their signal qualities. The transmitter facility may provide a pilot signal to remote receivers, over each antenna
In TDD applications, the correlation between the first bit(s) energy and channel quality is determined, shown by waveform 40 a. (In case of frequency division duplex applications, the monitoring device learns the correlation between a short segment of the pilot energy or other parameters and the channel quality). As shown by waveform 40 b, one or two symbols of signal A are analyzed followed by an analysis of one or two symbols of signal B and, immediately thereafter, the remainder of the time slot or frame is derived from the selected antenna 12 or 14 in accordance with the quality levels of the signals A and B.
The first one or two signals utilized for quality measurements and comparisons may be reconstructed through the utilization of error correcting codes or the like.
In the embodiment 44 shown in
In still another embodiment of the present invention, in third generation (3G) systems of the TDD and FDD types, there is a need for single quality measurements in order to make decisions regarding various processes. In the present invention, one example is a selection of a signal from one of the antennas to process for receive and transmit diversity. The desired measurement is typically related to signal-to-noise ratio which may be inferred from signal measurements. The present concept provides the ability to make decisions based on noise level when nothing else is known about the signal. As one example, broadband signal level is measured from the multiple antennas to decide among the antennas, such as antennas 12, 14 of
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US4977616 *||Oct 26, 1989||Dec 11, 1990||Motorola, Inc.||Antenna selection control circuit|
|US6137785||Mar 17, 1998||Oct 24, 2000||New Jersey Institute Of Technology||Wireless mobile station receiver structure with smart antenna|
|US6175723||Aug 12, 1998||Jan 16, 2001||Board Of Trustees Operating Michigan State University||Self-structuring antenna system with a switchable antenna array and an optimizing controller|
|US6434375 *||Sep 13, 2000||Aug 13, 2002||Neoreach, Inc.||Smart antenna with no phase calibration for CDMA reverse link|
|US6801514||Feb 6, 2001||Oct 5, 2004||Benq Corporation||Non-SDMA system with an SDMA method|
|US20030016637||May 25, 2001||Jan 23, 2003||Khayrallah Ali S.||Time interval based channel estimation with transmit diversity|
|US20030027540||Jul 31, 2001||Feb 6, 2003||Da Torre Serge Barbosa||Diversity combiner and associated methods|
|US20030031236||Aug 7, 2001||Feb 13, 2003||Erik Dahlman||Method and apparatus for selective demodulation and decoding of communications signals|
|US20030043887||Mar 29, 2002||Mar 6, 2003||Hudson John E.||Communication system and methods of estimating channel impulse responses therein|
|US20030067895||May 14, 2002||Apr 10, 2003||Interdigital Technology Corporation||Subscriber RF telephone system for providing multiple speech and/or data signals simultaneously over either a single or a plurality of RF channels|
|GB2305088A||Title not available|
|JP2001057526A||Title not available|
|JP2001203527A||Title not available|
|JPH06188792A||Title not available|
|JPH11284555A||Title not available|
|TW465199B||Title not available|
|WO2000076162A1||Jun 2, 2000||Dec 14, 2000||Broadcom Homenetworking, Inc.||Method and apparatus for determination of channel and baud frequency offset estimate using a preamble with a repetitive sequence|
|U.S. Classification||455/101, 455/67.11, 455/522, 455/510, 375/347, 375/150|
|International Classification||H04B7/08, H03C7/02|
|Cooperative Classification||H04B7/0811, H04B7/0868, H04B7/0857|
|European Classification||H04B7/08B2C2, H04B7/08H|
|Nov 30, 2010||CC||Certificate of correction|
|Mar 13, 2013||FPAY||Fee payment|
Year of fee payment: 4


OLYMPIA, Wash. (AP) — Democratic U.S. Sen. Patty Murray of Washington will face Republican challenger Dino Rossi in November.
Murray and Rossi advanced Tuesday through Washington’s “top two” primary, an unusual system that lists all candidates on the same nonpartisan ballot and sends the two highest vote-getters to the fall ballot.
Murray is considered vulnerable in her bid for a fourth term. She welcomed a primary-day visit from President Barack Obama to boost her momentum and campaign checkbook.
Rossi is a former state lawmaker who lost two close bids for governor.


text:
Ever have someone spin in front of you? Perhaps you recall at some point it looks like the spinning kart has stopped...just to find out, as you attempt to go around, it did not stop. Check out this video starting around the 40 second mark. Notice the spinning kart appears to stop then it changes direction…Read more
Tag Archives: Spin
- Tag Archives: "Spin"
Round 7 - Central Valley Championship Race
Practice: 10/7/2023 Race: 10/8/2023

domain: hobby


text:
As part of measures to improve the welfare of police personnel, the Police administration has re-introduced the shuttle service.
By this system, police personnel will be transported to and from their duty post in the nation’s capital Accra.
Addressing the media ahead of the official launch, Director General in charge of Administration at the Police Headquarters, COP Rose Bio Atinga said the shuttle system will ease the transportation burden on personnel.
She bemoaned the difficulties police personnel encountered reporting to their duty post and back home, hence the decision to lessen the burden.
“The hustle and bustle that personnel of the service go through on a daily basis in their bid to report for duty is not lost on the police administration; there have been instances that policemen have lost their lives whilst riding motorbikes to work, others have been run over by vehicles in accidents when walking or footing to their duty post and it is therefore in response to this plight that this welfare service has been reintroduced.”
COP Rose Bio Atinga added that the shuttle service will soon take a national dimension.
The vehicles will shuttle through zones including Dansoman, Odorkor, Adenta Housing Down, Legon police station, Korle-bu, Mamprobi, Weija, Sakumono and Nungua.

domain: news


Dry Weather, High Winds Fuel Wildfires
Fire Officials Urge Residents To Be More Careful
Fire crews have been battling fast-spreading fires and difficult terrain from Dunbarton to Hill.
Experts said dry weather and high winds are helping to fuel the fires.
Fire officials said it is pretty much a worst case scenario when it comes to brush fire conditions. The only thing that has been helping is the cool temperatures the state has had over the week.
"It's very dry, and the potential for these brush fires is very high," said Concord Fire Department Battalion Chief Ken Folsom.
Fire officials said several massive brush fires have been burning across the state, including a fire in Hill that claimed more than 70 acres over the past two days.
Crews also battled a fire in Dunbarton on Thursday.
Firefighters said the dry winter and spring, combined with windy weather, is creating a perfect storm for brush fires.
"This time of year, the grass hasn't turned green. None of the foliage is out and it makes the potential for fires very high," Folsom said.
When these fires do get going, fire crews said they are oftentimes very difficult to put out.
"They move very rapidly, they travel in areas that are difficult to reach. In the Dunbarton fire, they had to use a boat to get to the fire," Folsom said.
The state, meanwhile, is not issuing burning permits because officials said the risk of fire is so high.
"Particularly with the wind, you take a pile of dry leaves, and it only takes one spark and the woods is littered with dry leaves, and it doesn't take anything at all to get the fires going," Folsom said.
Fire officials said something as simple as an improperly disposed cigarette can start a fire that destroys dozens of acres.
"Smoking or anything like that, we ask people to make sure they don't put their cigarette butts out the window of their car that they put them In a good receptacle," Folsom said.


text:
|Roaster Location:||Madison, Wisconsin|
|Coffee Origin:||Not disclosed.|
|Review Date:||February 2009|
Orange- and lemon-toned fruit, a hint of cedar in the aroma. Soft acidity, smoothly silky mouthfeel, very complex in the cup: pipe tobacco, cocoa, a hint of flowers, orange and lemon. Orange and lemon in particular saturate the sweetly pungent, slightly astringent finish.
Available in a 12-ounce valve bag at $11.95. This coffee is certified organically grown and Fair Trade, meaning it was purchased from small-holding farmers at a "fair" or economically sustainable price. JBC Coffee Roasters (formerly Johnson Brothers Coffee Roasters) is a distinguished small-batch roasting company. Visit www.jbccoffeeroasters.com or call 608-256-5282 for more information..
Who Should Drink It
The socially and environmentally committed who don't want to give up on elegance.
Explore Similar Coffees
Click here for more reviews from JBC Coffee Roasters
This review originally appeared in the February, 2009 tasting report: House Blends: Comfort Coffee and Beyond

domain: food


text:
Special Issue - Winter 2013/14
Get ready to create gifts that are stylish and personal, and remember that even making something small and simple for someone is a meaningful act. More that forty projects give you a choice between fast an fabulous to true keepsake items, and everything in between. Projects in this issue: 6 festive and stylish decorating projects that are sure to brighten and beautify your home during the holidays including jingle bell pillows, snowflake ornaments, stockings, modern table-runners, stuffed reindeer and festive napkins; 6 embellished gifts using fabric, beads, and embroidery to add sparkle to purses, totes, brooches and tea cozies; 6 fast and fabulous projects - when you need a present in a pinch - that are quick and easy to create and yield dazzling results are earrings, purses, scarves, and ornaments; 7 great gifts ranging from cute to couture, that will satisfy everyone on your list including a messenger bag, patchwork pouch, card wallet, inuit doll, faux fur vest, pencil pouch and a baby bib; a special section on how to wrap everything up into gorgeous packages with a handmade touch; plus 12 favorite projects from the Interweave archives! Interweave Stitch Gifts Magazine - 2013/14.

domain: design


text:
According to the U.S. Bureau of Labor Statistics, South Dakota’s unemployment rate is 2.9%, the lowest since March 2020. But with nearly 23,000 job openings across the state, there simply aren’t enough people to fill all those jobs.
That’s why members of South Dakota’s business and agriculture sectors met for a virtual round table Wednesday afternoon to discuss a hot button option that could fill those job openings and continue economic growth: urgent immigration reform.
Kari Karst, CEO of BX Civil and Construction, said that her Dell Rapids-based company relies on a seasonal workforce and hires upward of 130 construction workers during peak construction season.
“We need immigration reform to continue filling those essential jobs, those hard jobs, with documented workers who are willing to work,” Karst said during the round table.
Nathan Sanderson, the executive director for the South Dakota Retailers Association, noted the state’s tourism industry relies heavily on a seasonal workforce. Tom Peterson, executive director of the South Dakota Dairy Producers, said without a reliable pipeline of workers, the dairy industry can’t continue to grow.
About 35,600, or 4%, of South Dakotans are immigrants and have a near $679 million impact on the state’s economy, according to the New American Economy, a nonprofit organization focused on bipartisan immigration research and advocacy.
However, bringing more immigrant workers to the state isn’t as easy as passing out more visas.
David Owen, President and CEO of the South Dakota Chamber of Commerce and Industry, noted two bills, the American Dream and Promise Act of 2021 and the Farm Workforce Modernization Act of 2021, have both passed through the U.S. House of Representatives.
If signed into law, the first would provide a path to lawful permanent residency and citizenship for DACA recipients, while the latter would provide a path to citizenship for undocumented workers and a path to permanent resident status for H-2A workers.
By Rebekah Tuchscherer for SIOUX FALLS ARGUS LEADER
Read Full Article HERE


text:
easy creamy chicken pasta. We've curated a bunch of recipes & tips to make cooking easier for you during this time! This creamy chicken pasta casserole would be perfect for those nights when you don't have a lot of time, but need something filling to feed the family. This one-pot pasta meal is easy to make with ingredients that you have on hand.
Just follow these easy steps to make this creamy pasta sauce which can be added to any pasta. Add the gruyere and parmesan and continue simmering, stirring occasionally, until the. Easy One Pot Cajun Chicken & Pasta Recipe. You can cook easy creamy chicken pasta using 7 ingredients and 5 steps. Here is how you achieve it.
Ingredients of easy creamy chicken pasta
- Prepare of boneless chicken breast.
- You need of cream of chicken.
- You need of cream of mushroom.
- Prepare of onion.
- Prepare of can of mushrooms.
- You need of peas.
- It’s of rigatoni pasta.
There are several ways you can customize this super simple and delicious one How to Make Creamy Cajun Chicken Pasta – Step by Step Photos. This Creamy Tomato Chicken Pasta is loaded with chicken, tomatoes, deliciously cheesy and a creamy sauce. How to make Creamy Tomato Chicken Pasta. It's super easy and simple to make this pasta dish.
easy creamy chicken pasta step by step
- put your crockpot on high and start to cut your chicken breast into small bite sized pieces, cut your onion and add both to the crockpot.
- season your chicken with salt, pepper, and red pepper. mix the chicken and onions up so it can spread evenly over all the chicken.
- add the cans of cream of chicken and mushroom along with the peas and mushrooms. stir everything..
- while the chicken is cooking follow the directions on your pasta, drain when done, set aside..
- cook the chicken in high heat for 4 hours, add the pasta, stir to get sauce over the pasta, and ENJOY ..
The hardest part is just getting all your ingredients all chopped up. By The Good Housekeeping Test Kitchen. Add lemon juice to skillet and cook, scraping up any browned bits. This rich and creamy Chicken Pasta With Bell Peppers is loaded with Parmesan cheese and as easy as it is delicious. This easy chicken recipe tosses together the winning combinations of pasta, creamy mascarpone cheese, and chicken–yum!


text:
As you know, the battle to control pests and keep your crops healthy can be daunting. Bugs become resistant; diseases evolve; and new pests arrive. The Society of American Florists’ Pest Management Conference, taking place Feb. 28-March 1 in Atlanta, will keep growers abreast of the latest developments in pest and disease management. A press release cautions growers “not to rely on old science to protect plants and profits.”
The conference offers the following for participants:
The SAF Pest Management Conference promises to be an important opportunity to learn directly from the leading minds in pest management today.
For more information, contact Laura Weaver at (800) 336-4743.

domain: biology


text:
This bar was completely custom built from premium white pine, poplar, and maple. The inspiration of the bar was to be mobile enough so that it could be moved if the owner ever wanted to change its location or take it with them to a new home. The removable bar top allows for the bar to fit through any door way with ease. We designed this bar for not only its use as an entertainment piece but also as a work of art in itself. The bar comes ready to be plugged into any electrical outlet for use of refrigerator, lights, and an outlet for a blender, etc.
We kept the look modern with lots of intricate trim work that catches the eye along with the tile backsplash.
This bar is our baby and we can't wait to find it a good home.


text:
It's okay, it happens to all of us. Enter your e-mail address or username to recover your password.
Nom Nom Nom.
A fresh variation from readers Krista Painter and Amy French, friends who first met in cooking school. According to the recipe notes, â€œOn weekly trips to Pike Place Market, they gathered fresh ingredients for their experiments. One outcome is this rich, green pesto.â€? Prep Time: about 10 minutes. Notes: This pesto is wonderful on orecchiette (â€œlittle earsâ€?) pasta.
For more features, and a better overall experience,
Please upgrade to Internet Explorer 10.
Click here to download Internet Explorer 9.


text:
|11-09-2012, 12:24 PM||#1|
Join Date: May 19 2008
[Techpowerup.com] (PR) Steam Big Picture Beta Available Today
Valve announces a major update to the Steam gaming platform called Big Picture. Steam's new Big Picture mode lets gamers access all of their favorite Steam games on a television. With the press of a button, Steam displays a new full-screen user interface optimized for readability and interaction on TV. Big Picture has been designed to be used with a traditional game controller, while also fully supporting keyboard and mouse input.
Steam gamers can experience Big Picture by connecting their PC or Mac to a TV, typically with a single HDMI cable. Access to the complete Steam store is included, as is the Steam Community. In addition to their complete library of Steam games, each user's cloud files, Steam Workshop content, account information and preferences will be accessible automatically in the new mode.
|beta, big, picture, steam, techpowerupcom, today|
|Currently Active Users Viewing This Thread: 1 (0 members and 1 guests)|
|Similar Threads for: [Techpowerup.com] (PR) Steam Big Picture Beta Available Today|
|Thread||Thread Starter||Forum||Replies||Last Post|
|[Techpowerup.com] 3 Million Dirt 3 Steam Keys of AMD Radeon Promotion Leaked||News||Reviews & News Online||0||06-09-2011 11:00 PM|
|Memset v4.1 Beta 4 / CPU Tweaker v1.5 (P55/X58) - tweaking Intel chipset memory timings||eva2000||General Software||19||22-09-2009 02:22 AM|
|[Techpowerup.com] (PR) Braid Coming to Steam||News||Reviews & News Online||0||26-02-2009 08:00 AM|
|[Techpowerup.com] (PR) Square Enix Delivers Games to PC Users Via Steam||News||Reviews & News Online||0||25-02-2009 07:50 AM|
|[Techpowerup.com] (PR) Steam Launches Hit PC Games from EA||News||Reviews & News Online||0||21-12-2008 12:52 AM|
All times are GMT +11. The time now is 07:33 AM.

domain: entertainment


text:
U.S. buyout firm Kohlberg Kravis Roberts & Co. had little trouble this week finding buyers for shares of a new fund that lets smaller investors participate in private equity.
But while the popularity of private equity IPOs could grow after KKR's $5 billion blowout offering, some say investors new to private equity should be careful, given the long-term nature of the investments and the fact the deals are coming as the returns on such funds are expected to drop.
There has been more and more money in the private world chasing fewer deals, and valuations have been bid up, warned Franklin Morton, a senior vice president of portfolio management at Ariel Capital Management in Chicago.
Private equity firms typically buy companies or controlling stakes, restructure the businesses, and sell them -- usually in three to five years -- for a premium. They pay for deals with a small wad of cash and use leverage, or debt, to pay for the rest. The firms keep a slice of the profit they make and give the rest back to their investors -- mostly large institutional entities such as pension funds, banks and endowments.
Another issue for smaller investors is access to information about fund performance.
If you are a large state pension manager who put up several hundred million dollars, they are going to take your call a lot faster than if you are a retail investor that buys a hundred shares, Morton said.
Returns for the top 25 percent of all funds have been huge in recent years -- exceeding 50 percent in several cases -- catching the eye of investors who have poured cash into the funds instead of the equities markets.
KKR's private equity unit made its debut on the Euronext Amsterdam exchange this week in a 200-million-share public offering. The deal was increased in size from the $1.5 billion the firm had initially hoped to raise.
KKR Private Equity Investors
The fund's quick success may spur others to market. The Blackstone Group and the Carlyle Group, two of the largest private equity firms, also are looking closely at their public market options, bankers say.
For now, a marquee name has gotten this into the collective unconscious, making investors more comfortable with the idea, said Edwin Pease, a partner with the law firm of Brown Rudnick in Boston.
Still, private equity is not for the faint of heart. Some say its best returns are behind the industry. The return of corporate buyers, competition within the buyout industry and frothy debt markets have prompted some private equity firms to pay high prices for companies. The more they pay, the less money they can give back to investors.
Historically, buyout firms have generally aimed to pay around five times a company's cash flow. But in the last year, buyout firms have consistently paid more than eight times cash flow -- in some cases, more than 10 times.
Given the lower returns expected going forward, the timing certainly raises a question, Morton said, speaking of the possibility of funds' selling shares to smaller investors.
Beyond that, private equity investing requires much more patience than owning stocks or bonds. In the private equity world, funds must be invested before returns dribble in several years down the road.
Private equity is a slow business -- don't expect miracles initially, points out Brian Rohman, managing director at Robeco Investment Management.
(Additional reporting by Michael Flaherty)


text:
Mavic HC Jersey - Short SleeveHigh performance race jersey. Update on our high end technical jersey offering both distinctive and refined styling, exceptional performance and fit Features:Hot Ride: Cycling softgoods designed for optimal thermo regulation at hot temperatures (> 25C/ 77F). Clima RideWick Matrix: Lightweight very breathable fabric with exceptional moisture transfer characteristics
The Mavic Cosmic Short Sleeve Jersey is a stylish jersey with all the features youd expect from a technical Mavic race top. First and foremost it performs incredibly well in the heat. Moisture management comes from our Ride Wick fabric, which is also really soft to the touch. And the air mesh inserts in the jersey sides provide great breathability. Meanwhile the look and style is full on Mavic,
The Cosmic jersey ensures comfort and breathability on every ride due to the use of Ride Wick ST fabric that offers excellent moisture transfer. Air mesh inserts on the sides allow for maximum ventilation on the hottest of days. The close fit construction eliminates fabric flapping while riding saving you precious energy particularly on longer days in the saddle. The ergonomic back pocket
The Raceline by Altura is a well insulated preshaped ergonomic fitted long sleeve jersey designed for comfort and warmth on those chilly winter rides.Super Roubaix fabric offering a high level of insulation and exceptional stretch propertiesFabric covered zipsHigh wickingStretch thermal brushed back fabricPreshaped ergonomic panel design for a perfect fit in the riding position3 rear pocketsDeep
Nalini Mantova Short Sleeve Jersey with its expertly tailored design gives you a comfortable advantage on your long rides. Using an ergonomic cut and 4-way stretch fabric for full range of motion, youll love how the jersey contours and moves with your body whether youre in the drops or on the hoods. This super soft warp-knit melange jersey self-regulates your body temperature and wicks away
Making a statement with your outfit has never been easier once you have this tropical print tunic by South in your casual collection. Bringing a touch of the tropics to your everyday wardrobe this tunic is a real head turner. The cartoon-esque print pops against the pastel pinks and bright whites while the lusciously lightweight fabric and boxy style keeps you cool and comfy all day no matter
Olympique de Marseille Away Shirt Short Sleeve 2014/15 SilverThis mens football jersey is a version of what lOM wear when they play outside of Stade Velodrome. Designed with climacool ventilation to keep you cool, this shirt features their proud team crest on the chest. Ventilated climacool keeps you cool and dry Contrast patch pocket on left chest Ribbed crewneck Olympique Marseille
The adidas Adizero short sleeve cycling jersey is a lightweight design for cycling in hot weather conditions. Made from lightweight fabric with an ergonomic cut, the cycling jersey features raglan sleeves for a full range of motion and mesh under the arms for increased ventilation. The jersey is constructed with a full zip closure, a low stand-up collar and easy access pockets on the back for
Make this navy-blue short-sleeve jersey shirt a part of your little one's wardrobe. Made of 100-percent cotton material, this shirt is comfortable to wear and pairs well with jeans or sweatpants. Made with cotton jersey material for comfort Machine wash for easy care Ribbed crewneck, tapered shoulders, and double-hemmed sleeves ensure durability Ash color is 99-percent cotton and
Order your normal Lacoste numeric size; US equivalent sizes have been updated. ; Look polished in an instant with this stylish polo. ; Breathable cotton jersey in a handsome stripe. ; Fold-over collar. ; Two-button placket. ; Hemmed short sleeves. ; Signature Croc appliqué featured at left chest. ; Straight hemline. ; 100% cotton. ; Machine wash warm. ; Made in Peru. Measurements: ;
Sentry HC Petromalt Hairball Relief contains a unique blend of ingredients, including lecithin and beeswax to emulsify and lubricate hairballs and aid in their passage without the use of petroleum. Your cat will love the highly palatable chicken taste! Symptoms of hairballs include constripation, straining during bowel movement, dry cough and vomiting after meals. If symptoms persist, consult a
Jon is checking his tyre pressures, hoovering his floor mats and putting an emergency packed lunch in the boot of his car, ready to hit the road again with a brand new tour Nidiot. The perennial singleton and misanthrope is determined to become a more easy-going person for the sake of his friends and his future health. Find out whether or not a leopard can change its spots, or if they are doomed
J. Cole 2014 Forest Hills Drive LP> Track listing:1. Intro2. January 28th3. Wet Dreamz4. 03 Adolescence5. A Tale of 2 Citiez6. Fire Squad7. St. Tropez8. G.O.M.D.9. No Role Modelz10. Hello11. Apparently12. Love Yourz13. Note to Self
A true Joules classic. Traditional and completely timeless with embroidery and the Joules signature to make this polo stand out from the crowd. Crafted from ever-reliable cotton pique to last season after season.
2 ball recommended only for small dogs. With extra wall thickness and bright two-tone colors these balls are great companions to the mini launcher and will help you excersize your small, high-energy dog!


May 3, 2012
MEMPHIS, Tenn. - Coming off a series victory against the highest-ranked opponent defeated in program history, No. 7 UCF, the Tigers host UAB at FedExPark in the final home series of the season. First pitch is slated for 6:30 p.m. Friday, 2:00 p.m. Saturday and 1:00 p.m. on Sunday.
Live stats are available on GoTigersGo.com and GoTigersGo.com provides live streaming video. You can also listen to the game on WUMR 91.7 FM. Follow Tiger Baseball on Twitter (@UofMBaseball) for in-game updates.
Weekend Full of Special Events
The Tiger baseball program has several special events planned around this weekend’s series with UAB. Saturday will serve as Senior Day for Patrick Bailey, Tyler Farley, Eli Hynes, Chase Joiner, Adam McClain, T.J. Rich and Jacob Wilson. The seven seniors will be honored in a pre-game ceremony at approximately 1:30. Prior to Sunday’s game, Head Coach Daron Schoenrock and the program will retire the jersey of the late Charlie Lea. Also, former pitcher Mark Bowlan will throw out the ceremonial first pitch. Pouncer’s Pals and one parent will receive free admission to Friday’s game. On Saturday, youth (8th grade and younger) wearing their team jersey will receive free admission to FedExPark.
The Tigers carry a 189-189 record in games played in May since the 1977 season. Memphis has had one season above .500 under Coach Schoenrock, a 9-7 record in 2006. Including postseason tournaments, the Tigers have been .500 or better in three of Schoenrock’s seven previous seasons. Memphis is 37-59 under Schoenrock in May.
Quality Starting Pitching
Memphis has 29 quality starts from its pitching staff in 44 games, 12 more than the staff posted all of last season. The Tigers have a 16-13 record in the 29 quality starts. In C-USA play, Langfield, Moll and Joiner have a combined 3.12 ERA with 92 strikeouts in 121.1 innings. Moll has a 1.81 ERA in league games and he has allowed nine earned runs in 44.2 innings of league play.
The Series With UAB
Memphis and UAB meet for the 80th time on Friday. UAB holds a narrow 40-39 edge in the series and the Tigers carry a four-game win streak against the Blazers into the series. Memphis swept UAB at Young Memorial Field last season and defeated the Blazers 5-4 at the C-USA Tournament. In the Bluff City, the Tigers are 20-15 against UAB with three sweeps.
The Inside Edge - UAB
The Blazers are coming off a three-game sweep of Houston over the weekend and sit at 26-20, 7-8 in C-USA, on the season. Michael Busby equaled the effort of Memphis’ Chase Joiner on Sunday as he tossed a complete-game shutout as well. Busby and the Blazer pitching staff have a 4.23 ERA and a very respectable strikeout/walk ratio of 2.3 (308/133) in 415.1 innings. At the plate, UAB is led by Jeff Schalk and his .319 average. As a club, the Blazers hit .267 with 19 homers and 229 runs scored. Ryan Ussery has a team-high four home runs and Patrick Palmeiro has 25 RBI.
The Tigers have recorded 77 doubles this season, but after averaging over two doubles per game the first 32 games this year, the squad has seven in the last 12 games. Adam McClain leads the team with 11 doubles on the year and Eli Hynes and Jacob Wilson have added 10. Memphis has recorded two or more doubles in 24 of 44 games, including the first 10 in a row.
Good Start, But What About Finish?
Last season, the Tigers pounced on opponents early, outscoring its opponents 156-81 in the first three innings. In the sixth through the final out, Memphis was outscored 156-115. So far in 2012, Memphis is outscoring opponents 71-64 in the first three, but opponents have outscored the Tigers 101-97 after the fifth.
Two Complete-Game Shutouts
Chase Joiner became the sixth pitcher in program history to record two or more complete-game shutouts in one season when he shutout No. 7 UCF on April 29. Joiner also shutout Siena on March 17. Joiner’s complete-game shutout against Siena was the first by a Tiger pitcher since Jarrett Grube achieved the feat on April 9, 2004. Joiner is first U of M hurler to post two or more complete-game shutouts since Collins Day recorded two in 1994.
Jacob Wilson and Adam McClain are in pursuit of top-10 positions in the record books for career numbers. McClain (240-4th) and Wilson (232-8th) are neck-and-neck as they ascend up the career hits list. Wilson has 57 career doubles which is third all-time. The two seniors are also climbing the charts in games played as Wilson (210-3rd) and McClain (206-5th) have eclipsed the top-five this season. Wilson recorded his 170th career RBI on April 28 to move to second place all time in career RBI. Wilson needs to score one more run to break the top-four in runs scored. Dan Langfield became the seventh pitcher with 200 career strikeouts and Langfield needs 38 punch outs to pass Lonnie Glass for second all-time.
Take Them How You Can Get Them
Memphis has scored 234 runs this season and the Tigers have produced those runs in 18 different ways. Singles (67), home runs (57) and doubles (35) account for most of the run producers this season. Sacrifice flies (14), triples (8), fielding errors (8), passed balls (8), throwing errors (8), groundout (5) , fielder’s choice (4), safety squeeze (3), infield single (3), bases loaded walk (3), double plays (3), wild pitches (3), hit batter (1), catcher’s interference (1) and balk (1) are the additional ways Memphis has put runs on the board.
Jacob Wilson hit a walk-off single with two outs in the ninth inning to give Memphis a 3-2 win over Austin Peay on March 13. The win was Memphis’ 15th when scoring three or fewer runs and first since March 26, 2011. Since 2006, Memphis is 18-106 in games where they score three runs or less. Last season, the Tigers were 1-15 with three or fewer runs scored. This season, Memphis is 2-15 when scoring three or fewer runs.
Looking For Production
Memphis is hitting .277 on the season, but a .202 average from the 8-9 spots in the order appears to be hampering the offense. The last two spots in the lineup have 59 hits and 39 runs scored, while the five hole in the lineup has 54 hits and 26 runs alone. In the three game set at No. 7 UCF, the 8-9 spots had seven hits and three runs scored to help Memphis to the series win.
No Need For Bullpen Today
Memphis starting pitching has combined to record five complete-game efforts this season. The five complete games are the most since the 1999 club posted six. This year’s pitching staff has the most complete-game shutouts since the 1999 season when Craig House and Josh Padgett each had complete-game gems.
Out of the Pen
Jonathan Van Eaton has six-straight outings without allowing a run (7.1 innings). Van Eaton has four saves in that span, allowed just one hit and struck out seven. In the last eight games, the Tiger bullpen has a respectable 2.61 ERA with Van Eaton, Patrick Bailey and Dylan Toscano not allowing an earned run in that span. Van Eaton’s six saves this season have him three saves away from the single-season record set by Matt Yokley in 2007.
Memphis vs. Ranked Opponents
Memphis has played 13 games against rank opponents this season. The Tigers are 5-8 in those games with wins over then-No. 7 Rice, then-No. 7 UCF (2), then-No. 18 Ole Miss and No. 24 East Carolina. Memphis has played 101 games against top-10 teams and the Tigers are 18-82-2 in those contests. Overall, Memphis is 80-232-2 against ranked opponents.
The Tigers played several nail bitters last season and in games decided by two runs or less, Memphis finished 9-14, 7-6 in league play. The Tigers had five come-from-behind wins and nine one run losses. The Tigers are 5-11, 2-5 in league play, in games decided by two runs or less this season. The Tigers are 48-48 all time in C-USA games decided by one run. In C-USA games decided by two or fewer runs, the Tigers sport a 72-80 record.
Strikeouts Adding Up For Langfield
Dan Langfield has ascended up the record books for career strikeouts he enters the weekend with 229 career strikeouts, third all-time. In just three seasons, Langfield has soared up the record books and if he continues his pace this season, he could finish in the top five for strikeouts in a season. Leading C-USA with 88 punch outs this season, Langfield is on pace for 111 strikeouts this season, which would put him fourth for single season strikeouts.
Memphis is hitting .248 (114-459) with two outs this season compared to .302 (148-490) at this point last season. The Tigers had 115 two out RBI and 304 runs scored through 44 games last year, but the U of M has mustered 67 two-out RBI so far this year with 234 runs scored.
The Tigers opened the 2012 schedule with nine of their first 11 games at FedExPark and went 4-5. The U of M carries a 49-36 home record since the stadium became FedExPark in 2010. Coach Daron Schoenrock has guided the Tigers to a 111-111 record at home since taking over the program in 2005. After a rough 4-20 home record in 2005, Memphis has a 107-91 mark at home.
Memphis is 97-143 under head coach Daron Schoenrock following a loss. After a 9-32 record in the 2005 season following a loss, the Tigers are 88-111 since. In the last three seasons, the U of M is 43-36 following a loss. This season, the Tigers are 13-11 following a loss.
Head Coach Daron Schoenrock has penned a lineup 44 times this season and each game has seen five or more underclassmen making starts. Memphis has had six underclassmen in the lineup in nine games and five underclassmen in 35 games.
Friday Night Lights
Memphis has struggled this season under the Friday night lights as the Tigers are 2-8 on Friday’s. Memphis is hitting .246 compared to .286 in the other 34 games. The Tigers average 3.90 runs per game on Friday and 5.74 in other games. On the mound, the Tigers have a 2.86 ERA on Friday, but a 4.31 ERA in other games.
The Tigers host Tennessee at FedExPark, the first visit the Volunteers will make to the Bluff City since the 1993 season. First pitch is scheduled for 6:30 p.m. on Wednesday.


text:
Over the past few years, Lankem have carried out research to develop a system that significantly reduces emissions from the combustion of diesel. To add validity to our findings an independent evaluation of our system was carried out by Manchester University to make direct comparisons of the emissions measured against standard diesel. The key finding was as follows:
41 % reduction of NOx at high load
34% reduction of CO2 at high load
Up to 69% reduction in particulate content
Reduction in high sooty particulates
Roughly 10% reduction in cost
For more please view the report
Also please contact firstname.lastname@example.org if you require any further information regarding the work carried out.

domain: chemistry


MULTI-TALENTED traditional and contemporary musician Japhet Mlauzi aka Hwabaraty, will release a collaborative music single titled Bavuma.
The Mqakezeleni hit maker better known as Dark Chocolate said he has set the date for the official release of the track alongside with its video on July 3.
Hwabaraty’s manager Ndabezinhle Ncube aka Bro Dash said the new track was an upbeat tempo meant to celebrate our richness in diversity as Africans.
“I am super excited to announce to all Hwabaraty fans and supporters that we will be dropping a power-packed single Bavuma featuring music producer and DJ Shirati.
“Bavuma is a song about acceptance. Only those that are brave enough to realise their purpose in life and go after their calling shall achieve greatness,” Bro Dash told the Daily News.
Hwabaraty said to him music comes from his inner heart. “My earnest desire is that everyone gets to connect with my soul through my music, I live and breathe music. This is my life and I want to touch lives through this God given gift,” Hwabaraty said.
The release of Bavuma shall be followed by a collaborative music video directed by creative producer and conceptual strategist Godwill Tasunga known in the arts fraternity as G-Factor.
The video collaborative act will feature some of the local creatives such as Mr Zimbabwe brand ambassador Ben Chest, second runner-up Miss Tourism Bulawayo Chipo Mandiudza and songstress Tynie Smart among others.
“We have already started to build hype over the release of the song following hashtag thread #Bavuma on all social media platforms. Hwabaraty also promised an online live performance upon the release of the song,” Bro Dash said.


text:
Jug of milk.
Royalty-Free Stock Photo
XS480x319px6.7" x 4.4" @72dpi230kB | jpg
S800x531px2.7" x 1.8" @300dpi583kB | jpg
M2500x1660px8.3" x 5.5" @300dpi3.4MB | jpg
L2744x1822px9.1" x 6.1" @300dpi4.4MB | jpg
XL3471x2304px11.6" x 7.7" @300dpi6.2MB | jpg
MAX4251x2822px14.2" x 9.4" @300dpi8.5MB | jpg
TIFF3536x2348px11.8" x 7.8" @300dpi23.7MB | tiff
Designers also selected these stock photos
More similar stock images
Jug of milk and a loaf of bread on a wooden boardCarrot waffles with powdered sugar on a wooden board with a glass of milk. Perfect healthy breakfastRelaxing time and happiness with cup of coffeeMilk jug. a glass of milk, cheese and eggsDifferent cheeses on table. Fresh dairy productsSomeone is pouring some milk out of a milk jug into a cup of coffee.Bowl with a whisk and dough for cake or pancakes, standing on a rustic wooden table. Near flour, rolling pin, milk in a jug, dropsHomemade chocolate dessert in kraft paper on a wooden table with a glass of milk and a clay jugandTop view to a cup of coffee and a jug of milk.
More stock photos from Astra490's portfolio


text:
- Lighthouse Lounge
- Our Location
Go paddling and explore Bruce Bay in Lake Huron.
Dip a paddle into Lake Huron and Bruce Bay and explore the shoreline of French & McKay Islands with the complimentary canoes, one man kayaks or row boats. Admire the different rock formations from Puddingstone to pink quartz…find the Kissing Rocks left by the glaciers many years ago.
Stop and enjoy the sandy beaches or the flat bluff rocks that make up the shoreline, look up at the rocky bluffs and watch the seagulls soar. Whether you choose to canoe or kayak along the shoreline you will find peace and relaxation as you calmly paddle.
On a calm morning or evening you could be able to paddle around both islands. Stop along the paddle at the many coves along the shoreline and observe the water fowl.
Complimentary life vests are found in the Recreational Lounge at Bruce Bay Cottages. Escape to Nature and just relax in your kayak and float along in the water and wait for nature to come to you…. just let nature revive you.

domain: travel


text:
Try These Awesome Games !
Another fun retro game! Choose your country and win all the other teams in this fun street soccer.
Love soccer? Love Zombies? Why not combine them? Choose your favorite teams and start blasting those darn creatures. Use mouse to ...
Choose your team and join the most prestigious soccer cup of them all, will your prevail or will you fail?
The innovative Penguin wants to fly and you're here to help! Learn the method and buy upgrades to help him on his mission.
A new updated version to the addictive zombie driving game. Slay all zombies using upgraded cars and weapons.
A crazed shooting game! Build your own warrior from various races and options and step into the war-zone, fighting countless e...
Will your survive the vexation? Jump, slide and try surviving in a world filled with platforms, traps and spikes!
Fight, loot, and upgrade in the sequel to Rogue Soul.
Potty racers are here, with more upgrades and LOTS more fun! Turn your potty into a plane and even a spaceship!
Ready to conquer space? Unlock multiple upgrades and try reaching your destination without crashing.


text:
Glaucoma and me – David’s story
David Scott was diagnosed with pigmentary glaucoma in his mid-30s, following a decade of living with ocular hypertension. Thanks to multiple surgeries, he has reached retirement age without the disease having a significant impact on his life.
In my experience, it’s best not to procrastinate about surgery if eye drops alone aren’t controlling pressures.
I was in my mid-20s when ocular hypertension (OHT) was first detected in 1987. I’d visited my GP on return from a skiing holiday (during which I’d accidentally headbutted a tree!), and she told me that the patterns at the back of my eye were unusual and ought to be investigated.
A decade later, my intraocular pressures (IOPs) could no longer be controlled by medication and I was diagnosed with pigmentary glaucoma.
I hadn’t been unduly concerned by the OHT but it did become worrisome when the pressures rose significantly and further action became necessary. I visited another consultant for a second opinion, and he confirmed the diagnosis. He said that laser treatment would be particularly appropriate in such a case, so I went on to have a laser iridotomy, which prevented pigment granules from being formed by the iris rubbing against the lens. This was followed 18 months later by an argon laser trabeculoplasty, which helped to clear old pigmentation blocking the trabecular meshwork.
After a long period of stability, my pressures began to rise again in 2013.
In 2015, I had XEN Gel Stents inserted into both eyes. These have been successful in improving drainage and lowering my IOPs (although I recently underwent a needling procedure to remove scar tissue that was partially obstructing the stent in my right eye). By 2021, pressures had once again risen sufficiently to justify additional selective laser trabeculoplasty (SLT).
Along with the surgery, over the years I’ve also tried several different medications. Most of them resulted in a degree of eye redness (probably caused as much by preservatives than the active ingredients). Since the stents were inserted it has been possible to avoid using drops entirely.
Although I had significant field loss in the period leading up to treatment starting, and experienced damage to the remaining nerve endings in my left eye around 2014, I can honestly say that glaucoma hasn’t significantly affected my life so far. Consequently, it hasn’t really impacted the lives of my loved ones either – apart from having to cope with listening to me talk about it! There is a family history of glaucoma: both my grandfather and father developed the disease. Indeed my father, who is 92, is now formally registered as sight impaired.
In my experience, it’s best not to procrastinate about surgery if eye drops alone aren’t controlling pressures. Most of the damage to my visual field occurred in a two-to-three-year period during the 1990s, and I can’t help but feel that this might have been avoided had the laser treatments been carried out more promptly.
When I think about the damage to my visual fields, I often find reassurance in the fact that when we ‘see’ something, it’s the brain that does most of the work. Interestingly, I read in Bill Bryson’s book The Body that it takes about a fifth of a second for information to travel along the optic nerves and into the brain, where it’s then processed and interpreted. To help us deal better with this fractional delay, the brain is continually forecasting what the world will be like one-fifth of a second from now. In other words, we spend our whole lives living in a world that doesn’t quite exist yet. How amazing is that?
I feel it’s important for people to know that glaucoma isn’t an older person’s disease, as my experience clearly highlights – I was only in my mid-20s when OHT was detected, and then in my mid-30s when glaucoma was diagnosed. The fact that it can cause irreparable damage to your vision without you even realising that there’s anything wrong shows why it’s so vital for people of all ages to get their eyes tested regularly.
Though my glaucoma was first identified by a GP, these days opticians can provide the first line of defence by measuring pressures and assessing visual fields as part of a standard eye test. And although it’s a lifelong condition, we thankfully live in an age where there are a range of treatment options available. So, with luck, it should be possible for me to continue keeping the disease under control for quite a few more years yet.

domain: medical


Authors: Maura Francis, Cory Boone, Jaclyn Wycoff
Multiphoton, or non-linear, microscopy, is ideal for capturing high-resolution three-dimensional (3D) images with reduced photobleaching and phototoxicity compared to traditional confocal microscopy techniques. This is the preferred method for analyzing thick samples of living tissue because of the technique’s advanced optical sectioning without out-of-focus absorption.
Multiphoton microscopy is a subset of fluorescence microscopy that uses similar imaging techniques of conventional widefield fluorescence microscopy to differentiate structures in living cells or tissues with various fluorescent tags known as fluorophores. Laser wavelengths of sufficient energy will excite the fluorophores to emit light that generates an image. Only one photon is needed to excite a fluorophore in conventional techniques. Out-of-focus fluorescence is often an issue in standard fluorescence microscopy due to fluorescence from other planes interfering with the focal plane. Traditional confocal microscopy combats this issue by blocking any out-of-focus light with a pinhole in front of the detector. However, this technique is not ideal for imaging thick specimens because of scattering and absorption. The image quality starts to deteriorate at thicknesses of around 100µm, but in certain samples image quality can be maintained as far as 700µm.1
As its name implies, multiple photons are absorbed simultaneously to excite fluorophores in multiphoton microscopy. The excitation light is confined to a very small three-dimensional volume (Figure 1), so this technique experiences lower levels of scatter compared to traditional confocal microscopy. The amount of light scattered is also inversely proportional to the fourth power of the light’s wavelength. Traditional techniques use ultraviolet (UV) or visible lights, which scatter considerably more than infrared light. The reduced scatter and absorption of the infrared wavelengths typically used in multiphoton microscopy allow for deeper penetration within a sample.2
Figure 1: The excitation light resulting from multiphoton microscopy is confined to a much smaller region of the sample than that resulting from single photon techniques.
Multiphoton and confocal microscopy are almost identical in terms of instrumentation, but multiphoton microscopy uses ultrafast lasers, such as femtosecond lasers. Ultrafast lasers have high peak power and short pulse duration, both of which are needed to excite the fluorophores. Many of these lasers emit in the NIR to IR regions and have high repetition rates, which has shown to be beneficial in biological, living samples.3 The high peaks in power allow for a higher resolution in imaging and contribute to the reduction in scattering. Unlike confocal microscopy, multiphoton microscopy does not require a pinhole because the out-of-focus fluorescence is significantly reduced due to the three-dimensionally confined excitation volume.
How It Works
A window is sometimes implanted into the subject being examined for maximum tissue penetration. Light penetration is typically limited to 1-2mm through the tissue itself. By using an infrared (IR) laser such as a Ti:Sapphire laser, less light is scattered and penetration depth increases.4 Longer wavelength photons have less energy than shorter wavelength photons and so, multiple IR photons are then needed to excite one fluorophore to a higher energy state (Figure 2). If a fluorophore typically gets excited with a photon wavelength of 350nm, then in two-photon microscopy that same fluorophore can get excited by two photons each with a wavelength of 700nm. The same concept applies to three-photon microscopy, except that three photons with triple the wavelength required for single-photon absorption are needed to excite the fluorophore. For multiple photons to contribute to a single excitation, the time lapse between them needs to be extremely short. This is why ultrafast lasers with short pulse durations and high repetition rates are needed.
Additional benefits of using the NIR wavelengths are that they allow for repetitive imaging and less scatter than UV wavelengths, which may also cause extensive photobleaching. Multiphoton microscopy circumvents several of the drawbacks of techniques based around UV excitation and allows users to image further into a specimen.4 UV wavelengths also cause more photodamage in biological samples.
Figure 2: In single-photon absorption (A), a single ultraviolet (UV) photon is absorbed to produce fluorescence. Multiphoton microscopy utilizes either two-photon (B) or three-photon (C) absorption, in which multiple photons are absorbed to produce fluorescence.
Multiphoton excitation will occur when the energies of multiple photons incident at the fluorophore simultaneously match the transition energy required to excite it from its ground state. The fluorophore will absorb two or three photons at once, depending on the technique (two- or three-photon microscopy). Absorption depends on the square of the intensity of excitation, so two- or three-photon absorption will only occur at the system’s focal point, where the photon density is the highest. This prevents any out-of-focus fluorescence from obscuring the image and eliminates the need for a pinhole, differentiating multiphoton microscopy from traditional confocal microscopy. Quick continuous pulses are sent into the system to increase the probability of simultaneous absorption.2 When such a laser is focused, the photons become more crowded, thus spatial density will increase.4 This also will increase the overall probability of fluorophores interacting at the same instant. Laser pulses with high peak powers and pulse durations on the order of femtoseconds are required for multiphoton excitation.
Since all fluorescence comes from a small volume at the point of focus, multiphoton microscopy collects the intensity of all the emitted light that comes from the specimen.5 The excitation laser is scanned across the sample to trigger fluorescence and generate the full field of view of the image. Because multiphoton absorption does not occur outside the focal volume, high-resolution images at different depths in the sample can be obtained. Due to the localized excitation causing no out-of-focus light to obscure the image, two-photon microscopy has the same resolution in the x- and y-axes as traditional confocal microscopy.5 Two- and three-photon microscopy techniques have a better z-axis resolution due to the fact that out-of-focus fluorescence is minimized in three-dimensions.5 This causes smaller cross-sectional areas to be collected, allowing for finer details to be distinguished, as seen in Figure 3.
In most configurations of multiphoton microscopy systems, photomultiplier tubes are used to detect signals with high sensitivity. This setup allows for fast data acquisition, which would be beneficial in applications that require near instantaneous feedback. Machine vision cameras with either charged couple device (CCD) or complementary metal-oxide semiconductor (CMOS) detectors can also be used in additional pathways to acquire a widefield image of the sample.2
Figure 3: An image of a mouse tumor captured using multiphoton microscopy, courtesy of the Laboratory for Optical and Computational Instrumentation (LOCI) at the University of Wisconsin, Madison.6
Figure 4 depicts the typical layout of a multiphoton microscope. A multitude of optics are present in a multiphoton system. The typical components that make up a multiphoton system are:
- IR Laser Excitation Source: IR source, such as a Ti:Sapphire or ultrafast fiber laser, emits a laser beam with femtosecond pulse durations and a high enough peak irradiance to induce multiphoton absorption in the sample. The high cost of Ti:sapphire lasers previously made this technique cost-prohibitive for certain situations, but newer and less expensive fiber laser sources now make multiphoton microscopy more accessible.
- Low group delay dispersion (GDD) Mirrors: their low GDD helps minimize chromatic dispersion and pulse spreading. These mirrors feature dielectric coatings optimized to provide high reflectance for the laser wavelength for which they are designed and to minimize GDD. Dichroic low GDD mirrors are used to separate emission signals at different fluorescence wavelengths, while low GDD scanning mirrors are used to pass emitted fluorescence to a detector.
- Bandpass, shortpass, longpass, and dichroic filters: different types of filters, typically bandpass or shortpass, are used to clean up excitation laser wavelengths and then to select particular wavelengths for detection.7 The filters allow for the nonlinear signals to be passed. Dichroic filters are often used to separate excitation and emission wavelengths.
- Objective: often a water or oil immersion infinity corrected objective, this component focuses the excitation source onto the sample, inducing multiphoton absorption at the focal point. Fluorescence is then collimated back through the objective and passed along to the detector. Objectives for multiphoton microscopy typically have a high numerical aperture (NA), high magnification, chromatic correction over a wide waveband, and a long working distance.
- Tube lens: placed behind the objective to focus the collimated fluorescence to obtain a primary image.
- Detector: a photomultiplier tube (PMT), imaging lens and camera, or other detector setup collects the fluorescence emitted from the focal plane, resulting in high-resolution images. 3D images can be generated by scanning through different planes of focus and stitching the images together.
Figure 4: Typical schematic of a multiphoton microscopy system.
Applications of Multiphoton Microscopy
Application 1: Brain Imaging
Multiphoton microscopy has allowed researchers to image deep into brain tissue in a way that they have not been able to do before. By employing a three-photon technique, researchers are able to image down into the hippocampus, which provides insight into how neurons are generated in the brain.8 Scientists are able to image in vivo, which can be extremely beneficial for diagnosing different pathologies. A study performed in mice employed multiphoton imaging to explore the functional effects of neurons and astrocytes in the progression of Alzheimer’s disease. Using in vivo imaging to see these structures can give scientists a greater understanding to the pathogenesis of the disease. By being able to see the brain via multiphoton microscopy, scientists and researchers can delve into how the disease progresses and develop better methods for treatment and diagnosis.9
Application 2: Retina Imaging
Multiphoton microscopy has also been successful in imaging the retina of the eye. Traditional methods of retina imaging prevent the observation of subcellular structures due to the optical aberrations the eye presents.7 Retina imaging can diagnose certain eye diseases and also identify degenerative brain diseases because of the retina’s role in the central nervous system. This can provide clues to onsets of diseases like Alzheimer’s or multiple sclerosis. Using multiphoton microscopy is especially beneficial in imaging the eye because the NIR lasers do not interfere with visible stimulation and the eye is optically transparent to longer wavelengths.7 The high spatial density of multiphoton microscopy provides excellent capabilities to evaluate the structures within the eye and gain insights into disease mechanisms.
Comparison to Other Microscopy Techniques6
|Light Sheet Fluorescence Microscopy
Multiphoton Microscopy at Edmund Optics®
Edmund Optics® supplies a wide range of optics for multiphoton microscopy applications including low group delay dispersion (GDD) mirrors, filters, objectives, polarizers, and gratings. More components ideal for these systems are continuously added as the multiphoton microscopy application space continues to grow.
Low GDD Mirrors
- Designed with High Reflectivity for Ultrafast Beam Steering
- Ion-Beam Sputtered Coated Options for Low Scatter and Absorption
- High Laser Damage Threshold Options
- GDD Down to 0±20fs2 at Design Wavelength Range
Ultrafast-Enhanced Silver Laser Mirrors
- Reflectivity >99% at 600 – 1000nm or 800 – 1150nm
- Low Group Delay Dispersion as Low as 0 ±20fs2
- Ideal for Ti:sapphire and Yb:doped Lasers
- Standard Imperial Sizes Available
UltraFast Innovations Pulse Compression Mirrors
- Highly-Negative Group Delay Dispersion
- Ideal for Ultrafast Pulse Compression
- Variety of Coatings for Common Wavelengths
- Industry-Leading Laser Optics from UltraFast Innovations
Low GDD Dichroic Shortpass Ultrafast Filters
- Reduced Thickness for Limited GDD
- Broad Transmission and Reflection Ranges
- Ideal for Ultrafast Laser Applications
- Controlled GDD Specification Using In-House Metrology
Ultrafast Thin Film Polarizers
- Ideal for Ti:sapphire and Yb:doped Ultrafast Lasers
- Optimized for Separation of S- and P-Polarizations at 45° AOI
- High Extinction Ratio of 1000:1 @ DWL
Olympus Water Immersion Objectives
- Water Immersion Objectives with Magnification Ranges from 10 to 40X
- Displays Flat Images from High Transmission Factors up to the Near-Infrared Region of the Spectrum
- Ideal for Fluorescence Imaging of Tissue and Specimens, such as Brain Tissue
Olympus X-Line Extended Apochromat Objectives
- High Numerical Aperture (NA) up to 1.45
- Chromatic Aberration Correction from 400 - 1000nm
- Uniform Image Flatness over Large FOVs
Mitutoyo Infinity Corrected Long Working Distance Objectives
- Long Working Distances
- Bright Field Inspection
- High Quality Plan Apochromat Design
- Flat Image Surface over Entire Field of View
- Long Working Distance for Simple System Integration
- Actively Aligned for Optimal Performance
- Ultra-Wide Spectral Band from 190nm to 11μm with No Chromatic Aberration
- Diffraction-Limited Options with Transmitted Wavefront of λ/14 RMS
- Wide Variety of Ruled and Holographic Designs
- High-Precision Options with Groove Spacing Tolerance <0.05%
- Custom Sizes Available of Many Grating Types
- Allen, John R. “Light Sheet Fluorescence Microscopy.” Nikon, https://www.microscopyu.com/techniques/light-sheet/light-sheet-fluorescence-microscopy
- Piston, David W., et al. “Multiphoton Microscopy.” Nikon, https://www.microscopyu.com/techniques/multi-photon/multiphoton-microscopy.
- “Two-Photon Microscopy.” Laser Quantum, https://www.laserquantum.com/applications/detail.cfm?id=24#:~:text=The%20laser%20used%20for%20two,interested%20in%20imaging%20living%20cells.
- Larson, Adam M. “Multiphoton Microscopy.” Nature, 22 Dec. 2010, https://www.nature.com/articles/nphoton.an.2010.2.
- Davidson, Michael W., and David W. Piston. “Introduction to Multiphoton Fluorescence Microscopy.” Olympus Scientific Solutions Americas Corp., https://www.olympus-lifescience.com/en/microscope-resource/primer/techniques/fluorescence/multiphoton/multiphotonintro/
- Wendt, Kristy. “Multiphoton Microscopy and Second Harmonic Generation.” Laboratory for Optical and Computational Instrumentation, University of Wisconsin, Madison, https://loci.wisc.edu/research/two-photon.
- Qin, Zhongya, et al. “Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo.” Light: Sciences Applications, https://www.nature.com/articles/s41377-020-0317-9
- May, Mike. “Shedding light on deep tissue: Multiphoton microscopy.” Science Magazine, https://www.sciencemag.org/features/2019/03/shedding-light-deep-tissue-multiphoton-microscopy.
- Kelly, Patricia et al. “In Vivo two photon imaging of astrocytic structures and function in Alzheimer’s disease.” Aging Neurosci, https://www.frontiersin.org/articles/10.3389/fnagi.2018.00219/full
- Santi, P. A. (2011). Light Sheet Fluorescence Microscopy. J Histochem Cytochem, 59(2), 129-138. doi: 10.1369/0022155410394857.
- Brightfield Illumination Microscopy
- Darkfield Illumination Microscopy
- Confocal Microscopy
- Differential Interference Contrast Microscopy
- Fluorescence Microscopy
- Light Sheet Microscopy
- Phase Contrast Microscopy
- Digital Microscope Objective Setups
- Understanding Microscopes and Objectives
- Ultrafast Dispersion
- Ultrafast Optics: Challenges and Solutions
- Highly-Dispersive Mirrors
- Ultrafast Lasers – The Basic Principles of Ultrafast Coherence


text:
The children and educators at ENCC have been working tirelessly preparing for our ENCC 2018 Art Exhibition
The Kinder 3-5 children have been experimenting with Paper Mache and paper clay, they have been creating some amazing pieces.
Being creative with Paper Mache is different to normal expressive arts and crafts as it requires children to plan ahead, it requires patience, persistence and forward thinking – Ruby has been working on her Giraffe for nearly 2 weeks now, quite impressive we think!!!
Another benefit of paper Mache is that it is an excellent way to reduce, reuse and recycle, the children have been using old newspaper, left over office paper and paper cut offs to create their masterpieces.
We can’t wait to show you the end result at our ENCC 2018 Art Exhibition on Wednesday 25th July.

domain: artistic


Electoral College gives rural states unfair edge
A recent letter commends the Founding Fathers for creating the Electoral College. Otherwise, the writer says, “At best, the choice of president would always be decided by the largest, most populous states with little regard for the smaller ones.” Ridiculous. States don’t vote. Citizens vote. Isn’t this a representational democracy based on the number of humans and not on the physical size of the states? Each election year the two presidential candidates have been determined long before the actual election in primaries by a small handful of rural ideologues. When the few on their vast acreage tell the many in the cities how the country will be run, that’s called an oligarchy.
Today nine rural states – Montana, Idaho, Utah, Arizona, Wyoming, North and South Dakota, Nebraska and Kansas (all reliably Republican) – between them have 42 electors in the Electoral College, not to mention 18 U.S. senators. Those nine states combined have fewer residents than New York State, which has only 29 electors and two U.S. senators. If “the founders wanted every voter in each state to have an equal voice” that makes you wonder why it isn’t New Yorkers whining about not being represented fairly. Add to that the fact that urban areas pay more taxes and get fewer taxes back than rural areas, and you begin to wonder how fair it is that this last election was “decided by the [smallest], [least] populous states with little regard for the [larger] ones.”
When you combine the lauded Electoral College with the current level of gerrymandering (another shameful practice begun in 1812 in the era of the founders) you can end up with a boorish billionaire president who has convinced gullible, mostly rural and Southern voters that he could somehow relate to, let alone solve, the problems facing the unemployed or the poor, even as he chooses more billionaires for his Cabinet and other appointments.
Stay tuned for the disastrous policies that soon will unfold from a president force-fed to all Americans – even those of us who live in states with actual people, rather than acreage.


text:
My August TU column. Read it here, or text is below.
I come to you on an August afternoon, fresh from vacation. Work and re-entry into real life is still a few days away, so I’m in post-vacation mode: laundry, catching up on email and stocking the refrigerator with real food, not booze or junk. I do all of these things happily because I have the glow, the zen, the relaxed vibe that can only come from a week by the shore. There is very little that can bother me today.
I am lazing about, basking in memories of a fine week spent lolling on the beach, playing cards and eating every bit of seafood that I could get my hands on. We kicked off our vacation with a late-afternoon visit to the beach. Parents were packing up small children and the sun was low in the sky as we dropped towels and ran to the waves. Oh, the joy in feeling the cold surf! After awhile, I sent Lucy to the snack bar and she came back with a big paper tray, fried clams overflowing. She forgot napkins, so we ate the salty strips and licked our fingers clean, then jumped in the ocean. It’s good to get to know the ocean again, after so many months away. I miss it, and its many gifts, when I am not there.
One of our collective vacation goals was to eat fresh seafood each and every day. Sure, we wanted to spend quality family time together and exercise and relax, but eating seafood was pretty high up on the list of importance, too. So we ate oysters (this was done sitting in big chairs at the ocean’s edge, with a cold glass of rosé), swordfish in tacos, salmon from the grill, lobster salad in greasy, toasted buns and rich, creamy chowder, studded with tender cod. One night, we bought a bag of clams, the small and sweet kind that the fishmonger recommended (he said, “They’re the best ones, sweetheart” and boy, was he right). I set them to boil in a pot with a stick of butter, plenty of white wine and handfuls of herbs. We plunked the pot in the center of the table and ate them up, dunking bread in the flavorful broth. They were the sweetest, most flavorful clams I’ve ever had.
But vacation is over. We’re back to work soon. School looms ahead; words I’m forbidden from saying in my house. There are no lobster rolls for lunch, no greasy clam strips late in the day. Instead I’m making salads with grilled chicken and noodles with cheese and vegetables. We’re back to a routine. What to do, though, when in the midst of all this day-to-day doldrums, a person wants a little taste of vacation? A tiny remembrance, a hat tip to the short but oh-so-sweet days we spent at the ocean? Cook up a little fish dinner, that’s what.
Fish has a reputation for being hard to cook, something saved for special occasions or eating out. But really, it can be quite simple. Preparing packets of fish — one for each diner — is easy, and it feels a little fancy, getting your own little package of fresh seafood. This method involves layering vegetables, then fish and topping with a few herbs. Make a few folds in the foil, grill or roast, and voila! Delicious, flavorful fish. And I didn’t even call you sweetheart.
The simplest recipe here is the classic grilled fish packet. It’s a great way to prepare the freshest of fish. Fresh seafood is mild, briny and sweet and a bit of lemon, a handful of herbs and a few vegetables is enough to complement it. One bite of this and I’m back at the ocean, if only for a moment.
These packets can rock bold flavors, too. Shrimp, scallops and cod are good backdrops for the flavors of Morocco and the tastes of Spain. Each recipe calls for small slices of lemon, tossed right in and cooked with the seafood and vegetables. I like the visual appeal of the lemon, and I’ll also eat the whole cooked slice. You could just squeeze the juice from half a lemon, if you like.
The Spanish seafood packet contains a bed of sweet peppers, plenty of garlic and a dusting of both sweet and smoked paprika. Green olives are salty and add color and long, wispy strands of thyme add a gentle taste that is good balance to the paprika. My family especially likes this preparation. A bed of rice makes a great partner to the smoky-sweet juices that come from the finished product here.
The Moroccan recipe is a version of chermoula — what I like to think of as Moroccan pesto. It’s a bright green sauce, similar in style to pesto, but made with pistachios, cilantro and parsley. Go easy with salt if you buy salted pistachios. You probably won’t need any at all, so wait until you’ve opened a packet and tasted the fish to add any salt.
What to serve with any of these seafood recipes? I like crusty bread with the classic fish packet and rice with the Spanish flavors. You could serve either flatbread or couscous with the Moroccan version.
Food — any type of food — holds memories for each of us. Seafood is that way for me: one bite of flaky cod, a tender mussel or a chewy bit of calamari, it all brings up summery feelings and memories. It’s the crash of waves and long, sunny days, the kind when you have nothing to do except plan where the next bite of fresh fish is coming from. Now, there’s no guarantee that you’ll suddenly feel like you’ve been lazing by the ocean all day when you dig into a grilled seafood packet. But maybe, just maybe, you’ll catch a tiny scent of the ocean and remember just how sweet life by the sea really is.


Saturday, September 12, 2009
Discovery's Return Wraps a Busy Space Week
Space Shuttle Discovery landed Friday evening, a day late and in California instead of Florida, but after a successful mission to carry supplies, including valuable scientific equipment to the International Space Station (ISS) and to implement an ISS crewmember swap.
Meanwhile, Thursday saw the launch of Japan,s first HTV cargo ship to the ISS and the static test in Utah of a 5-segment booster designed for the Ares rockets planned for future exploration.
All this on top of the release of spectacular post-servicing Hubble images and the release of the Augustine Committee summary report on future human spaceflight options earlier in the week.


text:
AC Milan head coach Stefano Pioli is likely to make two changes from the team that played Napoli ahead of Sunday’s trip to Parma, a report claims.
According to MilanNews.it, Milan left for Parma on Saturday afternoon after finishing training in the morning, and Lucas Paquetà will not be part of the plans due to a muscular problem.
Mattia Caldara meanwhile played in the Primavera on today, meaning Matteo Musacchio and Alessio Romagnoli will almost certainly be the centre-back pairing, while Mattia Gabbia will be on the bench.
On the right side Andrea Conti looks set to start, while Theo Hernandez is a certainty on the left.
In the midfield, Pioli will deploy Ismael Bennacer after his suspension, so Lucas Biglia will start from the bench. There is a battle meanwhile between Franck Kessie and Rade Krunic, with the Ivorian set to start. Hakan Calhanoglu is expected to start too given Paqueta’s injury.
In the attack, Krzysztof Piatek will still be favoured as the centre-forward over Rafael Leao , while Suso and Giacomo Bonaventura will flank the Pole.
Probable Milan XI (4-3-3): Donnarumma, Conti, Musacchio, Romagnoli, Hernandez; Kessie, Bennacer, Calhanoglu; Suso, Piatek, Bonaventura.


text:
Much talk has been generated about how fiber can help lower serum cholesterol levels. So much that some products with it are even “stamped” by the American Heart Association with a label saying: “Can Help Lower Cholesterol”. First of all there are two types of fiber: soluble and insoluble. They are both necessary, but it’s the soluble fiber that CAN contribute to lowering cholesterol.
OK, let’s discuss how fiber helps. There are in fact three theories as to why this works. And all three may in fact be true. The precise mechanism doesn’t really matter as much as the information I’m going to give you about it at the end of this article.
First, soluble fiber dissolves in water and then becomes gelatinous in consistency. It is in this form that it becomes able to literally bind to substances in the intestinal tract. When these substances are bound, they are then excreted from the body as part of human waste. First, one theory says the fiber is able to bind to bile (which contains cholesterol) in the intestines so that it does not get reabsorbed into the bloodstream.
Second, another theory says that it binds to bile acids in the intestines; again in order to prevent reabsorption. This mechanism would eventually cause a decrease in the amount of bile acids in the liver. As a result, the liver gets a “signal” to make more (whole) bile. The liver will then take up cholesterol from the blood in order to create more bile, as cholesterol is one of its components. So bile contains cholesterol and bile acids (in addition to other biochemicals). By the way, toxins are often bound to bile as well, so it becomes a route for detoxification. Hence, you’ll get lower blood cholesterol levels as it is pulled from the blood to make bile.
The third, more complicated theory basically says that soluble fiber shifts “bile acid pools” which leads to a decrease in the enzyme the liver uses to make cholesterol in the first place. Less production of cholesterol, means less serum cholesterol levels. You can read more technical information about that here, but I’ve covered the gist of it. The other two theories are “common” knowledge.
OK, what’s the common denominator in all three theories? Bile, of course. By the way, in case you didn’t know, bile’s function is to be released into the gut when fats are available to emulsify them in order for proper absorption of those fats (and fat-soluble vitamins).
Here is where the information stops! My question is: What is going to determine if you have bile in the intestines in the first place? As I stated above, fats must be available in the intestines. So now you go ahead and have a healthy “cholesterol-lowering” breakfast: some oatmeal and some added fruit, maybe you add psyllium to really increase the soluble fiber. More sources can be found here. And don’t forget the skim milk, you certainly wouldn’t want any added fat. Nah, you’re vegan or sensitive to dairy, you use water. Here’s another million-dollar question. Where’s the fat in this meal to stimulate the flow of bile in order for it to get bound by the fiber? As you know, the answer is nowhere. Now what? Well, your good intentions just got flushed down the toilet. No pun intended, but now that I think of it, pun intended.
The take home message is to include fat in the meal. So you can use whole milk and the vegan can use a grain-based milk. Nuts may be sufficient as well, if you’re not sensitive (and CHEW them properly). But if there is no other added fat, don’t use water or skim milk (I wouldn’t even use 2%). If you want to, use added coconut oil, then you’d really be doing yourself a favor. Oh wait, there’s saturated fat in it. So what? This notion of fat (even saturated fat) being bad for you is utter nonsense and terrible misinformation! And avoiding it to lower cholesterol is even worse information. Even if you avoid cholesterol itself, a negative-feedback loop will cause your body to make more cholesterol as your body senses the absence of it. If avoiding cholesterol was key, how could a vegan have high cholesterol? And believe me, some do. That’s all for another time. If you still won’t use any of these “oatmeal” combinations, eat it for dinner in hopes that there’s some bile left over in your gut from breakfast or lunch. Now, there may be a slight amount of bile released into the intestines with any meal, however that amount will be very poor without fat in the meal.
One last thing. Take a look at these foods (excuse me, name-brand products) with the stamp from the American Heart Association. Many of them, especially the breakfast cereals, breads, and desserts are not a good idea if you ask me. Read all the ingredients. It’s kind of like an investment banker showing you a document stamped with a seal that says “guaranteed 10% return on your investment”. Please don’t miss the print in the rest of the document stating that the fees equal 80%. You have to go the extra mile these days. Good luck everyone!
Dr. Robert D’Aquila – NYC Chiropractor – Applied Kinesiology


Our Blog - Insights and Impulses
The best mouse in the house or how to automate my washing machine?
We let our minds bubble for things that are close to our hearts and write about ideas and tinkering, insights and views from our digital world.
A new phase awaits The Schittigs. This spotlight traces the journey of the digital product agency from its inception to its current focus on digital strategies, complex technical challenges, and web applications with exceptional user experiences.
Who are my users? And what parameters do I need to consider when developing my product in order to perfectly match it to my target group?
Successful digital products require user-centricity. But how can we align the needs of our customers with the expectations of end users to create the ultimate customer experience?
"How are you?" "Good, thank you! And you?" might seem banal, but it's a phrase that is spoken without much thought day after day. No one expects an honest answer, at least not in a business setting. The "Thank you, I'm good" also implies that in the workplace, performance is expected regardless of how one feels. Personal matters often have no place in the job. Or do they?
It's a bit like magic when code interacts in the "real world". A perfect example of this is the transformation of an ordinary garage into a smart gate that can be controlled with a smartphone. With a few inexpensive electronic components and an ESP8622 developer board, anyone can create their own smart home project.
Nothing is more dynamic than the digital business world. Framework conditions and requirements can change over the course of the project, and we want to respond to this individually. That's why it's important to us that we no longer work with fixed-price offers. But how can we do it differently?
... or: How I learned to love the bomb. My personal journey into the wondrous world of machine learning-generated AIs. From fascinated immersion in a world full of new possibilities to worrying moments and the question: Who actually wrote this blog article?
A lot has changed in the last few years. Above all, most Schittigs work no longer in the office at all. Home offices, self-determined working hours and the odd office working day are now the norm. This presents us as an agency with some challenges. In this article, we will focus on one of them: the organization of the workplace.
The Schittigs not only have something to say, they have a lot to say. We take a stand on issues, problems and news that are whirring through the digital cosmos.


text:
Skip to comments.Poll: Millennials Leaving Democratic Party, Less Likely to Vote in Midterms
Posted on 04/29/2014 2:32:45 PM PDT by Kaslin
Is it really true that young progressives are leaving the Democratic Party and joining the ranks of the GOP? In a sense, yes, according to a newly published survey conducted by the Harvard University Institute of Politics, but that rightward shift isnt as significant as one might hope.
The Washington Examiner puts things into perspective:
It found that [the] youngest sector of the group, those 18-24, are becoming less Democratic and more Republican. In 2010, 38 percent called themselves Democrats. That has dropped to 35 percent. And those identifying as Republicans has edged up from 23 percent to 25 percent.
These statistics arent meaningless, of course, but are they earth-shattering? No. Far more interesting, I think, is the fact that the nations youngest voting bloc is politically disengaged, and unlikely to turn out in droves in 2014. From the actual survey:
Less than one-in-four (23%) young Americans under the age of 30 say that they will definitely be voting in the fall, a sharp decrease of 11 percentage points since November 2013 IOP polling (34%) and eight percentage points lower than seen during a similar time period prior to the 2010 midterm elections (31%: Feb. 2010). In addition, traditional Republican constituencies seem to be showing more enthusiasm than Democratic ones for participating in the upcoming midterm elections and are statistically more likely to say they will definitely be voting. For example, 44 percent of those who voted for Mitt Romney in 2012 say they will definitely be voting, a statistically significant difference compared to the 35 percent of 2012 Barack Obama voters who say the same. Additionally, self-identified conservatives (32%) are 10 points more likely to vote than liberals (22%); men (28%) are 9 points more likely to vote than women (19%); and young Whites (27%) are more likely to vote than African Americans (19%) and Hispanics (19%).
So while young Americans overall are less inclined to cast ballots in 2014 for obvious reasons, Republican-leaning constituencies are very much fired up. That's significant. Weve written extensively about how important the millennial vote can and will be in future election cycles. Thus, if millennials stay home in November, this could spell electoral doom for many incumbent Democrats, many of whom traditionally court young voters to help them win re-election.
Its also worth pointing out that while the presidents job approval rating has risen markedly since the survey was last conducted, it is largely African-Americans and Hispanics who are keeping his numbers afloat. For example, white millennials have all but abandoned him, or so it seems:
President Obamas job approval rating has improved six-percentage points since fall 2013 IOP polling, going from a previous low-water mark of 41 percent five months ago to 47 percent today. Since November, the president has seen steady gains across most of the major 18- to 29- year-old subgroups analyzed, although in most every case his job approval rating remained below 50 percent including on his handling of health care (39%: April 2014; 34%: Nov. 2013). President Obamas approval rating is buoyed by the steady support of the African American community (83% approve) and the solid support of a volatile (i.e., nine-point swing in one year, 21-point swing in five years) Hispanic community (60%); among Whites between 18- and 29- years-old, the presidents approval rating is 33 percent. Compared to the first IOP poll conducted during the 2010 midterm election cycle, the presidents approval rating during this midterm cycle is down nine percentage points overall, down 12 points among young Whites and nine points among young Hispanics and Latinos however, among African American voters there has been no change in approval over the same period.
Even if President Obamas core young constituencies give him positive marks overall, what good will they do for the party if they stay home in November? Not a whole lot, obviously. Unfortunately for Democrats, however, that's a real possibility.
The only excited and motivated voters are the conservative ones who have a distaste for RINO’s. The rest are demoralized or indifferent.
In a recent special election in my area, less than 20 percent turnout with 48 percent going to the Tea Party write-in, 27 percent to the GOP candidate who was a RINO, 25 percent to the Democrat.
They’ll be replaced by illegals.
When our demographics change enough, there will be U.S. polling places in Mexico, Honduras, Panama, Nicaragua, etc.
time to Bring Out The Dead!
2014 Midterms in a nutshell. The Angry Vote always wins!
They have seen the ‘fruits’ of their support for Obama........................
So more don’t like either party than do. Just shows that millennials are not as stupid as people would have you believe.
I don’t think they are going Republican, they are simply through with voting now that Obama magic mouth has done nothing to change things, which was what they assumed what happen.
They elected him, showed the world they are cool, and now it’s over.
As long as our culture is rotting, election victories are futile.
in 2008,what percentage of college students were either incompetent or had an IQ under 50? who in their right mind votes for a presidential candidate who obviously wanted to collapse the economy?
According to Reason magazine, libertarian millennials voted for Barack Obama.
“Young Libertarians Voted For Obama”
Emily Ekins|Dec. 11, 2012
We can and probably will win the midterms but I think we’re done winning the presidency without taking a long hard look at reality and correcting some things.
The GOP is busy kicking conservatives in the teeth and conservatives are busy kicking libertarians in the teeth. There’s simply no hope of winning like that.
Too bad these morons have already screwed this country badly with there previous voting.
“Theyll be replaced by illegals.”
For her entire life, my grandmother was a staunch Republican. But since she died she’s voted the straight Democratic ticket.
odds are these babies will have more important things to do on election night.just like the 20% of the lazy uneducated voters who dont have time to stand in line to vote being they will be pre-occupied with all of their “Free Stuff”.
there should be their
If Republicans would get some conservative backbone, they would win it all, but they are browbeaten by the baby killers, amnesty pimps, Obamacaring frauds, globalist warmers and aggrieved minorities, all the people who will never vote for them.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

domain: sociology


text:
PrairieFest Restaurant Week, brought to you by the Oswegoland Park District, Village of Oswego, and the Oswego Area Chamber of Commerce creates the same unity as the community’s beloved festival through shared culinary experiences. This delicious week highlights the wide-ranging and delicious dining options of our local restaurants. Whether around your kitchen table or a dining room in Oswegoland, we are all invited to enjoy a week of amazing meals at top-tier restaurants and neighborhood favorites. All of these specials are available to you all week. So, map out your eating route, and have a delicious week around town!
Showcase Your Restaurant February 19 – 26, 2022
Oswegoland dining guests are taking a culinary adventure around town this February. We want your establishment to be a part of it. The earlier you give us your information, the more we can share about your business with the community. Participation is complimentary. Restaurants can submit information through this form until February 1. After that point, PrairieFestRestaurantWeek.com will be used to promote your details to our interested guests.
For any questions, contact Kristie Vest, Oswegoland Park District at firstname.lastname@example.org.


text:
Hey everyone, it’s Eric Su. I wanted to share with you a quick workout solution for anyone who is super busy like some of my clients. You will learn the squat challenge and the 5 to 20 minute workout routine. So much that you can do with this workout plan you will be amazed. Also,..
Awsome interview with Ruari Fairbairns. The founder of One Year No Beer. Ruari is an Entrepreneur, Senior Oil Broker running the number 1 JET desk & Co-Founder of the OYNB movement. He gave up drinking in the face of incredible peer pressure, thinking he would lose his edge as one of the Top brokers in..

domain: health


text:
You are reading His Majesty Secret Heroine (Official) manga, one of the most popular manga covering in Manhwa, Webtoon, Josei, Mature, Adventure, Comedy, Crossdressing, Drama, Fantasy, Full Color, Gender Bender, Historical, Martial Arts, Romance, Supernatural genres, written by Han soo young,Lee do kyung at ManhuaScan, a top manga site to offering for read manga online free. His Majesty Secret Heroine (Official) has 155 translated chapters and translations of other chapters are in progress. Lets enjoy.
If you want to get the updates about latest chapters, lets create an account and add His Majesty Secret Heroine (Official) to your bookmark.
Lokheun’s name means "happy morning," but her life takes a tragic turn when her mother is murdered and her father becomes a fugitive after exacting revenge. To save him, Lokheun devotes her life to Garyun, the dashing emperor who’s committed to right the wrongs of his father. Believing Lokheun to be a boy, Garyun is determined to mold her into an unsurpassed martial artist, even if it means sending her to hell. Their strained relationship turns into something more as Lokheun searches for the one thing she’s never had: a life befitting her name.

domain: literature