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We offer finance ranging from personal to business financing to interested persons and companies who are seeking financial assistance or growth. We offer large and small amounts of finance to our clients. We also offer Long and short term financial service with a reliable guarantee. contact us via Email: email@example.com
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domain: finance


Ever since their introduction into the automotive industry, lithium-ion batteries have proven to be an exemplary power source. They have even powered the development of the industry and the invention of superior and eco-friendly electric cars. For decades this battery has provided more than enough energy to sustain the evolution of technology as well as the automotive industry.
Is there a better car battery than lithium-ion?
There has been a never-ending debate on whether or not there could be a better battery than the lithium-ion cell. However, even with this ongoing debate, lithium-ion continues to widen its gap in the lead for the best battery technology available in the market. Scientists are also focusing on improving or upgrading this battery technology because they have shown renowned prowess as a power source and therefore, replacing them may not be an option just yet. Lithium-ion battery technology may not be disposed of just yet as we have merely tapped into the potential that its other versions have.
How do you choose a good lithium-ion car battery?
Choosing a good lithium-ion car battery isn’t as simple as one might think. It involves getting to know all the facts and features about the specific kind of battery that your car needs and making the right choice. Also, everyone works with a budget when it comes to buying a battery for their vehicles and this is no exception for lithium-ion cells because they tend to be expensive. Not only should you consider the needs hat your car and pocket can accommodate, but also those of the environment you drive in.
Furthermore, keep in mind that lithium-ion batteries designed for vehicles are not universal as seen in the way a truck with a bigger engine would need a bigger battery than a small saloon car. Proper research is required before making any purchase concerning these batteries and the following are a few ideas to help you get started.
1.Check on your budget for the battery
Lithium-ion batteries can be quite expensive. Therefore, to know the best battery that would fit your needs as well as those of your car; you need to figure out how much money you are capable of spending. Normally, a regular lead-acid battery would not be more than 100 – 200 $ price range. Some of these cells can even be bought at a lower price point and especially the low-grade batteries that only need to sustain your car for a short period.
However, if you’re interested in performance as well as higher energy densities and stronger resilience to environmental conditions, you will have to spend more. You cannot compare the performance of a lithium-ion battery to that of a low-cost lead-acid cell and even though you wouldn’t have to overspend, you may need to prepare yourself for a substantial price tag.
2.Pick the right capacity and size battery
Lithium-ion batteries come in various sizes and capacities. For you to choose the best battery for your car, you will need to keep track of the exact size and capacity that your vehicle uses. This will allow you to buy the most appropriate battery that will not bring about measurement issues during installation or provide a smaller energy density that what your car requires. You can look into your car owner manual for the details about such information.
Alternatively, you can extract the existing battery from your car and take the appropriate measurements. Once you got the data, you can look for the best retail store that provides the batteries at some of the most suitable offers in the market.
There are many lithium-ion batteries for cars designed by different battery manufacturers. The performance of the battery is one of the most significant factors one has to consider for their vehicle needs. You can check your owner’s manual for the minimum cranking amp value that the vehicle needs and get batteries with a higher cold cranking amp rating.
Lithium-ion batteries are far much better than the old lead-acid batteries and thus you may find than with their small sizes, they are capable of supplying large energy densities. Also, these cells have little to no maintenance allowing them to lower the cost of running your vehicle on the road.
There are also a few variables that you would need to consider before making your purchase. The environment in which you drive; and the magnitude as well as usage frequency of electronics in your vehicles will also help you make a better decision. A lithium-ion battery with a higher CCA rating will perform better in extremely cold places while that with a lower rating runs best in hot areas. For heavier vehicles, a higher CA rating is more suitable as they require more cranking amps.
How much is a lithium-ion car battery?
There is no fixed price for lithium-ion batteries because different manufacturers have different price tags for their batteries. Also, there are many overlying factors that determine the price of a lithium-ion car battery. Some of these factors include lifespan, capacity, warranty, and many others. You will have to be specific on the details of the desired lithium-ion battery to know the exact amount that it costs in the market.
However, researched analysis shows that the standard price of an entire automotive lithium-ion battery pack lies within 500 – 600 $ per kilowatt hour. However, the prices of batteries has generally declined and therefore, the price of lithium-ion car batteries today can fall up to about 200$ per kWh. As years go by, the prices of these batteries are expected to go even lower than normal due to increased supply levels. Generally, lithium-ion batteries are considered expensive and especially those designed for vehicles.
Some people are still convinced that there is a better technology than lithium-ion when it comes to vehicles. However, study and research has proven that lithium-ion batteries are capable of handling all the energy requirements needed for cars. At the moment further studies are being carried out to try and upgrade the battery rather than replace it therefore leaving lithium-ion to remain the most suitable vehicle battery in the market.
lithium-ion battery e-bike battery lithium battery


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A total of 15,229 candidates have passed the 43rd (Special) BCS preliminary examinations.
Bangladesh Public Service Commission (BPSC) published the results today on their website.
In the notification of 43rd BCS, it has been said that 1, 814 officers will be taken in public sectors. Of these, 300 will be appointed in administration cadre, 100 in police cadre, 25 in foreign cadre, 843 in education cadre, 35 in audit, 22 in information, 19 in tax, 14 in customs and 19 in cooperatives.
A source from PSC informed that the chairman had called for an emergency meeting at 3:30 pm today and decided to publish the results.
On 29 October 2021, the 43rd BCS Preliminary Examination was held in Dhaka, Chittagong, Rajshahi, Khulna, Barisal, Sylhet, Rangpur and Mymensingh.
The number of applications submitted was 4, 35,190 lakh.

domain: news


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US DoJ extradites alleged AirBit Club Ponzi operator from Panama
United States Department of Justice (DoJ) and the Southern District of New York (SDNY) extradited a member of an alleged AirBit Club ponzi scheme for “internationally coordinated fraud and money laundering ring” and being allegedly involved in defrauding individuals “through investments in AirBit Club.”
In a release published on Monday, 30 November DoJ identified one Gutemberg Dos Santos, a citizen of Brazil and the United States as one of six operators of AirBit Club. Dos Santos, who was arrested on 18 August 2020, in Panama City faced trial before the SDNY and now remains in US custody. Acting United States Attorney Audrey Strauss spoke on the matter and said:
As alleged, Gutemberg Dos Santos played a key role in an international investment scam that promised extraordinary rates of return on phantom investments in cryptocurrencies, defrauding victims of tens of millions of dollars.
DoJ alleged Dos Santos and another five operators hosted lavish events aimed at convincing victims to purchase AirBit Club memberships that promised guaranteed returns. According to the DoJ, after a victim invested, a Promoter provided them with access to an online AirBit Club portal to view the purported returns on memberships. The DoJ also alleged that while victims saw “profits” accumulate on their Online Portal, those representations were false:
No Bitcoin mining or trading on behalf of Victims in fact took place. Instead, Rodriguez, DOS SANTOS [and others] enriched themselves, and spent Victim money on cars, jewelry, and luxury homes, and financed more extravagant expos to recruit more victims.
The AirBit Club’s still-active website indicated some of the aforementioned events with the most recent taking place in Sao Paulo, Brazil, last year. In addition, among the six indicted was Scott Hughes, a California attorney who, the DoJ alleged, helped to “remove negative information about AirBit Club and Vizinova from the internet.”

domain: law


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Kwesi Slay - Seven ft. Kwesi ArthurBy KellyChi December 21, 2021, 09:28 am Comments
Are you here to Download Kwesi Slay - Seven ft. Kwesi Arthur mp3? then scroll below.
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Multi-Award winning artist, Kwesi Slay has introduce us with a brand new astonishing vibrant song titled ”Seven ft. Kwesi Arthur”
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More For You: Kwesi Slay ft. Kofi Mole - Work

domain: entertainment


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As the President of the International Olympic Committee, Jacques Rogge, opened the envelope to reveal Tokyo, Japan's capital, had beaten Madrid and Istanbul to be given the opportunity to host the biggest sporting event on earth, there was always going to be jubilation with a hint of controversy. Tokyo showed both passion and determination to secure the vote which would make Japan the first ever Asian country to host the Olympics twice.
Their first time hosting the Olympics was in 1964, involving such athletes as British long jumper Mary Rand and race walker Ken Matthews. Great Britain only managed to win four gold medals compared to our incredible haul of 29 at London last year. Given the success of the 2012 games, I'm sure most Brits would happily have the Olympics here every four years. However, there are 199 capitals and several hundred more major cities in the world; all with varying levels of suitability.
So, the big question is, is Tokyo fit to host the Olympics?
You cannot doubt their credentials. Boasting one of the finest infrastructures in the world, including the renowned 'Bullet Train'. Their respected and charismatic president, Shinzo Abe, even claimed that Tokyo would be ready 'To host it tomorrow.' Japan has one of the most secure economies in the world and their GDP, which is the third highest in the world, looks far more attractive than what Spain or Turkey can currently offer.
Inside a large theatre in Argentinian capital Buenos Aires, Tokyo were clear favourites. However, there was one question regarding their suitability which stood out above all others. Will the athletes and spectators be safe from radiation, given the ongoing problems at the Fukushima nuclear power plant?
Shinzo Abe had a planned response. 'In 2020, seven years from now, there will be absolutely no problem. The radiation level in Tokyo is the same as London, New York and Paris. It's absolutely safe, 35 million people living there in very normal conditions. We have no worries.'
So there you have it. The president has made a clear promise that millions of tourists who descend onto Tokyo in 2020 will be perfectly safe from the catastrophe which occurred 150 miles away from the country's capital more than years ago.
Another interesting question regards whether Tokyo's bid was successful because of its strengths, or Madrid and Istanbul's weaknesses?
Madrid would have made an excellent city to host the Olympics. However, it is an unfortunate fact that they simply would not be able to afford it. A country which has a 27% unemployment rate and a youth unemployment rate of 56% would be better off investing the potential Olympics funding to help their country's economy, rather than attempt to inspire their next generation.
Barcelona's 1992 Olympics sadly failed to do just that, leaving stadia and facilities to rot inside Spain's second largest city. It is clear now that financial security is the base requirement for a city to host the Olympics. Madrid would certainly make great hosts, but not amid their financial crisis.
As for Istanbul, the bid couldn't recover the damage caused by the recent street protests, doping scandals and the sheer quantity of match-fixing allegations in their top-flight football league, the Super Lig. This scandal has left teams stripped of titles, European statuses and has most certainly destroyed reputations. This has raised concerns over the legitimacy of other sports in the country. If those concerns were to be raised during the Olympics, it could cause complete embarrassment for Turkey and their bid which vowed to 'Unite two continents – Europe and Asia.'
From two years of lobbying, Tokyo have overcome both the recent tsunami and the Fukushima disaster to create a sound presentation, fighting off fierce rivals who all had justified reasons to host the biggest sporting event. They showed resilience and a strong sense of direction regarding their plans if they were given the green light to host the games.
Although it is 7 years away, the world is excited to arrive at one of the biggest and most cultured cities on earth to watch their country strive for glory in an event which brings the whole world together.


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Meet Judy Isaacs, Tails of Joy’s sewing angel.
With a house full of kids and grandkids, and a heart as big as the Grand Canyon, Judy Isaacs has an endless supply of rescued cats (9) and dogs (4) enjoying safety and love in her home. Judy has paid out of pocket for years, to spay/neuter/save feral neighborhood cats, as well as helping every needy animal she and her family have come across. Judy teaches quilting and sewing in NYC, and now, hundreds more animals will be saved thanks to Judy’s amazing talent, kind heart and generosity, and incredible donation of her work to Tails of Joy. Everything Judy makes is unique and of the highest quality, yet we keep the prices low so everyone can enjoy this beautiful artisan work that saves lives.
Judy’s Fabulous Goodies for Tails of Joy
Click on item for details.

domain: artistic


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Homophobia & Transphobia
Content Warning: The following section contains content surrounding the history and current presence of homophobia, transphobia, biphobia, and other anti-LGBTQ+ rhetoric and prejudice. This content may be sensitive to people who identify as LGBTQ+.
Homophobia: hatred and aversion towards gay people, or people perceived as being gay. This can sometimes manifest in hateful humor and comments, rigid adherence to and policing of gender roles and expression, and social exclusionary processes. Homophobia also manifests in targeted physical, emotional, interpersonal, legal, and institutional violence.
Transphobia: hatred and aversion towards transgender (trans) people and/or any other gender expansive people regardless of identity. This can sometimes manifest in the subtle and/or overt denial of the gender identities of individuals, intrusive questions, comments and microaggressions, and fetishization of trans folx. Transphobia pervades all spaces: LGB+ spaces, the healthcare system, prisons, academic institutions, etc. Transphobia also manifests in the targeted physical and interpersonal violence, sexual violence, and murder of trans people.
Biphobia: hatred and aversion towards bisexual people as well as other folx who hold attraction to more than one gender. This can sometimes manifest in denying the existence of bisexuality, the endorsement of bisexual stereotypes, and the fetishization of bisexual people.
Due to experiencing homophobia, transphobia, biphobia, and other forms of hatred and oppression, queer people are exposed to greater mental health and physical health disparities than the general population. Keep reading for more specifics on these disparities.
Currently, folx who are part of the LGBTQ+ community face increased physical and mental health disparities due to discrimination, both structural and interpersonal. Queer folx as a community are exposed to additional harms that increase suicidality, depression and anxiety, substance use, homelessness, violence, and more. These harms exist within a range, from family rejection to hate crimes to legislative discrimination. Certain groups with intersectional identities experience increased harm and discrimination. For example, Black trans and non-binary folx are more likely to be incarcerated, homeless, assaulted, and murdered.
These issues do not solely exist outside of the Stanford bubble. Queer, trans, and non-binary students at Stanford face social, mental health, physical, and financial barriers in navigating prejudice from peers, faculty, staff, and family members. Navigating housing systems, administrative forms, athletic teams, mental and physical health systems can be extremely taxing for those who are not represented structurally and socially. Transgender and gender-nonconforming students are more likely to be targets of sexual violence on campus. Queer, trans, and non-binary faculty and staff also are exposed to prejudice and/or discrimination and may not disclose their identities, thus affecting their mental and emotional health and consequently work. Despite positive movement in terms of social awareness of LGBTQ+ issues, political and social systems continue to exclude, neglect, and harm those in the queer community.
In order to explain why this is currently happening, it’s important to retrace our steps and look at queerness through history. Despite current and widespread prejudice, queerness and gender diversity has existed and persisted across time and culture. From the highly respected gender diverse individuals in some Native American tribes to rituals of same-sex relationships in ancient Grecian cities and African tribes to the gender transformations and same-sex relationships of ancient Hindu gods, history has shown the diversity of love, attraction, and gender across cultures.
Multiple factors contributed to the oppression and erasure of these cultures. The rise of patriarchy and particular monotheistic institutions that condemned same-sex relationships and gender role fluidity was followed by early psychology’s pathologizing of same-sex attraction and science’s embrace of natural selection. With these belief systems being enforced throughout the world by European/white imperialism and colonialism, much of the world’s queer traditions, peoples, and cultures were eradicated and erased from both existence and historical narratives by white colonization. Though U.S. culture has continued to evolve, our ideas of gender, sex, and attraction still stay rooted in these prejudicial and oppressive forces.
While aspects of queer liberation in the U.S. has gained momentum over the past century thanks in large part to the civil rights movement and queer activists of color, we continue to find ourselves in a battle between queer freedom and oppression. While same-sex marriage has been legalized, protections for trans and non-binary individuals continue to be stripped away. While queer communities continue to reconnect and reclaim queer history and ancestry, U.S. mainstream culture and government continues to erase this existence in classrooms, history books, media coverage, and social structures (sometimes called straightwashing). The lives and experiences of queer folx, especially trans people of color, continue to be targeted by systems still impacted by religious prejudice, imperialist erasure, and social stigma.
It is imperative that these systems are changed, and even dismantled, in order to protect the lives and experiences of queer, trans, and gender non-conforming members of our U.S. communities. We can stop the discrimination and murders of LGBTQ+ individuals, protect those who do not fit into archaic binary conceptualizations of gender and attraction, and move towards a culture of care that celebrates diversity of connection and expression and the intersectionality of race, sex, class, and gender identities. In order to get there, we must work individually, interpersonally, socially, systemically, and legally.
Being in solidarity with a community against oppression requires both an intersectional lens and ongoing praxis. We know from the main anti-hate landing page that oppressions intersect. To fight one type of oppression would be incomplete without continuing to learn about and fight the other interlocking oppressions that target and magnify the harm experienced by individuals and communities. For example, to fight for queer rights would also include fighting for racial justice since those who are most impacted in the queer community by oppressive systems are queer and trans folx of color. Second, to fight against these systems takes continued learning and continued self-care; social justice work necessitates humility, ongoing education, and self-preservation. Taking care of ourselves ensures that we can continually and sustainably strive for liberation.
First and foremost, continue to educate yourself on aspects of identity around gender, sex, and attraction. Start with this Queer 101 video to learn about current conceptualizations of identity in the U.S. Follow queer educators and activists of all different disciplines and backgrounds in your social and traditional media. Learn about queerness through time and culture. Learn about the stories of queer people of multiple racial and spiritual communities. Diversify your media and entertainment so it includes a wide range of representations of love, sex, attraction, gender, race, ability, class, etc. Continue to learn, fight your own internalized prejudice, and be humble in your process.
Second, commit yourself to solidarity with all parts of the queer community. The queer community is expansive, permeating all cultures, nations, religions, and societies, and exists on a spectrum. Solidarity with the queer community entails being an active upstander when hearing prejudicial speech or witnessing discrimination towards any part of the queer community, not just those who are in our racial/ethnic, socioeconomic, etc. circles. It means having conversations with others so that queer folx don’t always have to be the ones to shoulder that burden. It means modeling appropriate and inclusive language and practices in your community, work, family, and faith.
Reallocate, center, and elevate
Third, help to reallocate attention, resources, and power. While being an ally is important, elevating and centering the voices and experiences of LGBTQ+ folx is key to shifting systems. Donate time, money, and energy to organizations and movements focusing on queer issues and communities. Make sure that the organizations and businesses you support with your money have diverse queer representation, initiatives, leadership and mentorship, inclusive language, etc. Fight for inclusive changes in the structures you’re a part of, like making bathrooms where you work accessible for all genders, changing language on forms and materials to be gender inclusive, advocating for initiatives highlighting queer issues and experiences, and seeing more clearly how heteronormativity and the gender binary system show up in your personal and professional spheres to exclude and invisibilize LGBTQ+ folx. Share news and entertainment centering queer folx of all backgrounds. Amplify the voices of queer folx, encouraging privileged folks to decenter their experiences and step back in conversation. Create spaces of visibility where folx can gather in community, protected from outside harm.
Finally, vote to change the legislative structures that harm the queer community. From the repeal of Don’t Ask, Don’t Tell to the passing of same-sex marriage, key legislative victories have shown that every single vote makes a difference. Listen to the policy suggestions from intersectional queer organizations and civil rights groups and vote accordingly. Vote in leaders who also listen to these policy suggestions. Put pressure on current leaders and systems by communicating via town halls, email and mail, op-eds, and through social media.

domain: sociology


[Linux4christians] Bandwidth Allocation on Router?
samuel.clough at trumpetsofzion.org
Mon Mar 16 17:52:08 EDT 2009
I'm currently using Tomato on my Linksys router and I know it has a traffic
prioritization feature. They recommend using it, for example, to prioritize
Vonage traffic to make sure it trumps any downloads. I've never had any
problems though so I don't currently use it.
On Mon, Mar 16, 2009 at 6:09 PM, Pastor David <pastordavid at bibleseven.com>wrote:
> Linksys WRT-300N
> Can I set bandwidth allocations on individual connections to my
> router, please?
> When the kids are streaming games or movies or my wife is downloading
> a large picture or video clip I have trouble getting enough bandwidth to
> accomplish tasks in the home office.
> Also, anyone used the access restrictions feature in this router to block
> porn and spam?
> Have an http://Ultrafidian.com Day! Pastor David
> Personal Site: http://bibleseven.com
> "Before the Beginning was God. At the Beginning was Wisdom.
> After the Beginning angels & man took a big dumb-pill." dmc
> 10 Acres & 2400SF Home For Sale in Florida - ask me.
> Linux4christians mailing list
> Linux4christians at thelinuxlink.net
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Mykonos & Island Cruising » Review by Explorer1258016
The Greek Islands are an absolute must-do! And Contiki was a great way to see them. The parties in Mykonos are so much fun and the cruise ship was a great way to see the other islands. A brilliant holiday and great friends!
Review written Sep 2011event 0.3

domain: travel


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Viduet helps you set up your patients’ care pathways as efficiently as possible. This way, you’ll gain a better understanding of your patient’s health, and you can spend your time as efficiently as possible. Together with your patient, you can create a personalized care program using different care modules. Care modules focused on exercise and weight loss can easily be combined with other care modules for diabetes, asthma, COPD and CVRM, for example. Learn more about the care modules that can be used to help patients lose weight and move more.
With the Viduet Waste and Move care module, physical therapists and other healthcare professionals can remotely coach their patients to get enough daily exercise. Special software on the Fitbit Versa smartwatch supports patients in meeting goals agreed upon with their practitioner. Informal caregivers are notified via text message when their family member needs a helping hand. See below the Waste and move care module.
If you would like to know more, please contact us.
When you want to guide patients to lose weight, you can choose to use the weight monitoring care module. Within this care module, the patient receives a scale linked to Viduet. Because all weight measurements are sent directly to Viduet, you get a reliable picture of the patient’s weight and BMI.
In addition, a questionnaire can be sent at desired times that can help the patient to actively work on their weight goals, stop smoking and/or stop drinking alcohol. That way you get a better picture of the process and can help the patient lose weight in a targeted way.
This care module combines well with the Activity Coach. This way, you not only gain insight into weight and BMI, but you can also coach the patient in a targeted way to exercise more.
Exercise is an important factor that can affect patients’ health. Using the Activity Coach care module, you will ensure that your patient is coached to adopt optimal movement patterns.
When you choose to deploy the Activity Coach, the patient will track their movement patterns through the smartwatch. Using our specially developed software for this smartwatch, patients will be coached throughout the day to move within the ranges set by their healthcare provider.
This care module can easily be combined with coaching by a physical therapist. In that case, the physical therapist can set the optimal bandwidths and adjust them as needed. Through a smart algorithm, Viduet recognizes when the patient moves out of bandwidth for an extended period of time. Viduet can then also inform the physical therapist in the desired manner so that the set bandwidths can be revised if necessary.
Many treatment programs have one or two treatment sessions per week.
The Activity Coach developed by Medicine Men helps patients exercise more, less or enough. The software for the Fitbit Versa smartwatch supports the patient throughout the day in meeting agreed-upon goals. Clinicians can adjust individual step goals interactively with the patient, as well as use a special A.I. algorithm that suggests adjustments to the patient based on the past period.
“We received the complaint from many physical therapists that patients seem to move little between weekly sessions, but have no idea how little. With the activity coach, we have now developed an elegant combination of greater insight into what a patient does during the week and an advanced coaching program that continues invisibly between sessions.”

domain: medical


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Rajkummar Rao’s Newton trailer released today and this Amit V Masurkar’s film looks quite intriguing. The film portrays Rajkummar as Newton, who is on an election duty in a jungle area of Chhattisgarh.
In the trailer, Rajkummar can be seen leaving no stone unturned to conduct a fair election despite the fear of Maoist attack in the jungle. The trailer is looking interesting and it begun at a serious note when Rajkummar along with his family went to see his prospective bride and refuse for the relation as he comes to know that the girl is below eighteen years.
At the end of the trailer, Rajkummar also revealed the mystery behind his name Newton, which is interesting.
The film is scheduled to release on September 22, 2017.


Gear Education at Gear Expo
Gear Expo provides an opportunity to learn from the industry's experts by walking the aisles and talking to exhibitors. Visitors to Gear Expo 2001 also can take advantage of some formal training and educational opportunities sponsored by AGMA and SME.
Gear Expo Trivia Challenge
You've attended Gear Expo so many times that you think you're an expert on it. Test your expertise with this quiz.
Detroit Trivia Challenge
You've been to Detroit several times for Gear Expo, so you think you know Motown pretty well. Prove it. Gear Technology has a quiz to test your knowledge of the Motor City.
The "Unofficial Guide" to Gear Expo 2001
We've contacted many of the companies that will be exhibiting at Gear Expo 2001 to compile the following directory of exhibits. Use this directory to help plan your visit to the show, or to stay up-to-date on the industry's suppliers and technology.
Museums, Casinos and Motown: The Detroit Outside Cobo Center
Besides Gear Expo 2001, Detroit is home to a museum with an 1896 Durya Motor Wagon, America's first production car; home to a casino in a building that use to be Internal Revenue Service offices; and home to the studio where Diana Ross and the Supremes recorded "Stop in the Name of Love."
What "Ease-Off" shows about Bevel and Hypoid Gears
The configuration of flank corrections on bevel gears is subject to relatively narrow restrictions. As far as the gear set is concerned, the requirement is for the greatest possible contact zone to minimize flank compression. However, sufficient reserves in tooth depth and longitudinal direction for tooth contact displacement should be present. From the machine - and particularly from the tool - point of view, there are restrictions as to the type and magnitude of crowning that can be realized. Crowning is a circular correction. Different kinds of crowning are distinguished by their direction. Length crowning, for example, is a circular (or 2nd order) material removal, starting at a reference point and extending in tooth length or face width.
Face Gears: An Interesting Alternative for Special Applications - Calculation, Production and Use
Crown gearings are not a new type of gear system. On the contrary, they have been in use since very early times for various tasks. Their earliest form is that of the driving sprocket, found in ancient Roman watermills or Dutch windmills. The first principles of gear geometry and simple methods of production (shaper cutting) were developed in the 1940s. In the 1950s, however, crown gears' importance declined. Their tasks were, for example, taken over by bevel gears, which were easier to manufacture and could transmit greater power. Current subject literature accordingly contains very little information on crown gears, directed mainly to pointing out their limitations (Ref. 1).
Gone Fishin' - Back After Gear Expo (Publishers Page)
It's summertime in the gear industry. Out my window, I see blue skies, green grass and trees swaying in the wind. In the background, I hear crickets chirping.
Letter to the Editor (Voices)
Current Letter to the Editor for September/October 2001.
Product News (Product News)
Complete Product News for September/October 2001.
Welcome to Revolutions, the column that brings you the latest, most up-to-date and easy-to-read information about the people and technology of the gear industry.
Hidden Runout (Q&A)
Q&A is an interactive gear forum. Send us your gear design, manufacturing, inspection or other related questions, and we will pass them to our panel of experts.
Technical Calendar (Events)
Complete Technical Calendar for September/October 2001.
Industry News (Industry News)
Complete Industry News for September/October 2001.
Puzzling Together A Gear Pioneer (Addendum)
The Dictionary of American Biography describes him as "one of the founders of the gear-cutting industry in the United State." He built the first hobbing machine for cutting spur gears. He founded the companies that are now Boston Gear and Philadelphia Gear Corp.


It was weird being with the same five people for so long and only seeing others through a screen.With the return of this exciting event format, attendees will have more opportunities to interact with the entire Lightning roster, while still maintaining the competitive spirit of a traditional golf tournament.4 ‘Super Bowl LIX TBD Feb.
I love SpongeBob because he is a hero, and who does”t want to be a hero.Javier Báez, Chicago Cubs 9.Kris Bryant, Chicago Cubs 16.I just hope it continues.
‘NFL: It was learned Sunday morning that a Patriots player tested positive for COVID-19 during Saturday’s round of testing, which caused their facility to be shut down as a precaution.The ten-episode, one-hour series is set to premiere in July, according to VH1.’NFL: It was learned Sunday morning that a Patriots player tested positive for COVID-19 during Saturday’s round of testing, which caused their facility to be shut down as a precaution.Aaron Judge, New York Yankees 3.
15 Baltimore Ravens at New England Patriots ‘Nov.Fan-cestry will be supported by POP and social media.Coaches receive training and everyone has fun while learning the game of football.Real Madrid soccer $4B 7.
According to Mary-Ann Somers, chief growth officer for Intuit’s Consumer Group, Americans work hard for their money and at Intuit we want to help them find and save more of it.Los Angeles Rams NFL $3B 12.With one player having this was the right thing to do.
New York Jets at Los Angeles Chargers moves from Week 6 to Week 11 Sunday, Nov.27 Tennessee Titans at Green Bay Packers ‘Jan.22 Kansas City Chiefs at Las Vegas Raiders ‘Thursday Nov.The guy that we saw late in the year can be an NFL starter, and Haskins himself needs to remember that.Los Angeles Dodgers MLB $3B 14.
When teams in the smaller markets are winning, that becomes a big factor.This is really just the beginning for me.New stadia can help propel this driver, and sometimes a new manager.Cristiano Ronaldo $105 million $60 million $45 million Soccer 3.Anthony Rizzo, Chicago Cubs 14.
Several members of the community whom Simmons has impacted surprised him with the nomination after sharing why he had such a great impact on them.And we have worked with Patrick Kane, among other NHL players.3 TBD Highest-Paid Athletes 1.Missing and making shots is a part of the game, but I’ve got to do a better job, and that’s on me.Jacksonville Jaguars at Los Angeles Chargers moves from Week 8 to Week 7 on Sunday, Oct.
He is the highest-paid actor in Hollywood, earning $64 million over the past year from his recent movie roles, according to , including and ., an animated film from Disney in which he voices Maui, one of the lead characters, hit theaters in late November at No.I’m sure that’s going to be motivation for her, not liking to see another name up there.Los Angeles Dodgers MLB $3B 14.Roger Federer $106 million $6 million salary winnings $100 million endorsements Tennis 2.In addition, Ito Ham will sponsor the Fighting Spirit Award.It’s yet another instance of the obvious choice being the correct one.
Manchester United soccer $3B 11.


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The Colossus of Akhenaten, in a combination of trapunto quilting and goldwork, is now finished.
I added a few extra details, to sculpt the face a bit more – tiny stitches in silk, broadening and deepening the eye sockets, altering the shape around the nose, adding more stitches attaching the face.
In fact, to make sure the silk was fine enough, I twisted it myself from a spool of Japanese silk bought for the purpose. I think I ended up with three twisted threads from one length.
The gold kid of the headdress now has an upper edge trim as well. That would have been much easier to do if I could have done it before attaching the kid to the head!
As I was looking over the whole thing, it occurred to me that Akhenaten’s hands weren’t convincingly grasping his crook and flail. Fixing that wasn’t hard in theory – new hands cut from the edge of the silk, padded with padding from the edge of the piece, and attached with more hand-twisted silk thread.
In practice, it took several attempts before I was at all happy with the result, and I could be seen contemplating my own closed fist thoughtfully at various points in the process. Which doesn’t always help as much as you might think, when the aim is something slightly different to a realistic representation….!
However, I now think he’s probably as finished as I can make him. As I wrote to a friend: I may have doubts about detail, but I think Akhenaten is now as good as my current level of skill will allow. I hope someone will take him off my hands before I get good enough to shudder every time I look at him!
I feel as though I’ve spent as much time on Akhenaten’s accessories as I did on the silver purl loincloth, and tied myself in as many knots as I did when I was doing his wig!
I do hope he starts to approve of my efforts again soon…
When last seen, I was content with the crook, done in alternating blue and gold wire rope, strung on a former made of fuse wire, but I was expressing doubt about the flail.
The gold purl and silk wrapped purl was too frail, and this version, using gold wire rope, was visually too heavy, and much too springy. So I knew that something else would have to be devised, and racked my brains repeatedly for ideas.
The ideas finally came late one night, and – too drowsy to wake up properly and write notes – I fell asleep hoping I wouldn’t have forgotten in the morning.
Fortunately, I hadn’t!
I’m assured that the word for the parts of a flail that flail is “swipple”, which sounds too outrageously appropriate not to make use of.
The various turquoise beads came from a friend on Instagram, who saw my wrestlings with the armlets and offered some treasures from her stash to assist. After several trials, I settled on a combination of gold and coloured beads, and a particular length of loop.
The finished flail has a handle of gold wire rope, a head of gold pearl purl, and four strung bead swipples. In fact, the inner two swipples have different coloured beads to the outer two. This is part of the layering of detail I’m trying to develop with Akhenaten, to help with the impression of rich gorgeousness I want to convey. It might be barely noticeable (although more so in real life), but it will break up what might otherwise look a bit monolithic.
I’ve taken the same approach with the wristlet, which uses silver rough purl (leftover from the loincloth) in combination with a pale pinkish rough purl. Anything single-coloured was too obvious and argumentative, especially as it’s placed right in the centre of his chest, but when I left it out entirely, that looked worse!
You may recall that I had some trouble with the armlets the first time I was working on them. Now, as I’ve come back to Akhenaten again, I’ve decided that the gold kid I’d settled on isn’t at all right. Off it came, and after some puzzling, I attached the brass mesh instead.
Only to decide that no, that looks dull, doesn’t capture the effect I’m after, and even edged with a flattened gold spiral, doesn’t stand out enough against the silk.
My next thought was to do some patterned chipwork. I chose a rather gorgeous, very ancient-Egyptian-looking blue, and a sort of diagonal basketweave pattern which is not a million miles removed from some of the patterns I have seen on ancient pieces.
The blue did at least help the silk to show something like true colour, but when I looked at the whole piece, I found the blue too bright, and the pattern altogether too much of a good thing.
I thought that was strange. The alternating directions should have echoed the beard and helped the two sit nicely together, and there is so much personality in the silver purl loincloth that you would have thought nothing could have been too much!
Then I had a thought – the kit for the Stuart Silk Purl Flower contained some bonus silk-wrapped wires and purls, and fortuitously, when slightly overstretched, there was just enough of one of the turquoise ones to do top and bottom on each armlet.
At this point I decided, somewhat tentatively, that maybe I’d got this bit right, or at least right enough to move on.
The small leaf was rather “meta”, in a way, because long “stitches” of silk purl were couched down with shorter ones. I’ve likened it to Burden Stitch, or even the couching form used in some opus anglicanum, and it includes colour changes as well.
All of these techniques have been simple enough in concept, but the execution isn’t simple at all. Spacing, angles, and cutting the lengths are all, as The Australian would say, non-trivial (mathematician-speak for “quite tricky”) and practice may make perfect in the end, but it hasn’t done so yet!
The final leaf was worked by alternating the hummocks and simple couched techniques of earlier months. In a way this shows that it is possible to create new textures by “layering” or “overlaying” techniques, so the only limits are in the stitcher’s imagination.
It creates an interesting ribbed effect, although with all my care, the raised hummocks aren’t all raised to the same degree. That said, I defy anyone looking casually at the real thing to notice the fact – at only about three inches by five, that would be a lot of detail to be able to distinguish!
And there are other dazzlements in store…
The final detail is to add spangles, which are reliably confusing and dazzling to the eye.
Just imagine all that flickering in the candlelight and shadows of the silk purl textures casting mysteries over each other!
I’ve thoroughly enjoyed this Online University course. Now I only need the time to sit down and read the extra information and watch the videos!
Having decided that all those delicious manipulations of brass mesh weren’t going to help in this case, I cut out the shape of the cobra’s hood from the brass mesh, (not getting too close, in case I cut the thread attaching it!).
At this point I realised it wasn’t quite strong enough, and attached the bent piece of pearl purl from the first attempt to the back in order to provide more support.
Bending back the brass mesh helped to conceal the supporting pearl purl – although whether anyone will be able to notice it is a moot point!
The final stage of the cobra was to attach the same piece of silver spiral with gold band to take the place of the snake himself, in front of the hood and to a new piece of gold kid. This time I looked again at some pictures of cobras, and made sure the hood was set back a little from where the mouth would be.
I used the same “vulture’s head” as last time, but helped it to stand out slightly by winding some blue wire from a tiny bit of blue purl around the large gold rope I used for the vulture’s neck. You can see how small it is, but it’s surprising how much difference it makes to the final effect!
Once I’d attached the gold kid, I could cover the bottom edge with gold spiral, and then trim the upper edge to create the shape I wanted. This is the stage you see here. However, I then decided that the upper edge needed a trim, so at some point I must tie myself in knots to attach some sort of trimming to a curved shape stretched over a padded base.
Wish me luck!
Of course, I had to take off the gold headdress when I decided to make another attempt (and another, and another!) at the face. Then, when I looked at it again, with my new version of the face in place, and still more new ideas swirling around in my head, I decided that it wasn’t quite right, either in shape or in conception, and needed a little more help…
First of all, I think the first piece of gold kid I cut was the wrong shape, but secondly, and more interestingly, the cobra doesn’t really stand out against the gold kid, so I decided to try again.
So I began by folding a piece of brass mesh and attaching to it a loop of the same blue twist I used to emphasize the edging of the belt. I had thought that this might be rather tricky, but the brass mesh is fine enough to take stitching without too much trouble.
At this point I should probably say that from the base to the top of the loop here is no more than a centimetre. This is all very small and very fiddly indeed!
I also experimented with some pleating and crinkling of the brass mesh. I like the various effects, and I’d love to fit them in somewhere, but unfortunately I couldn’t quite work out how to make them work in this context.
The whole piece is so striking that I am finding it particularly difficult with the last little details, because they need to have enough personality not to be overwhelmed, but I don’t want the final piece to feel “spotty”. The eye needs somewhere to rest occasionally, rather than zooming frantically in all directions!
There was quite a lot to do in the second month, learning new ways to wrangle silk-wrapped purl.
The first element was composed of the loops of purple, short lengths bent in two and controlled by an extra small couching stitch to hold them in place.
This is a technique I’m sure I’ve seen before, and I must say I rather like the effect, although I found it rather worrying to do. The purl is small and fragile, and I think that at the moment I still don’t quite have the headspace to do as well as I would like.
I do think, however, that the time for just not doing it is passed. If I want my skill to come back to me, I will have to use it! Who was it who said, “the more I practise, the luckier I get”? I would like my embroidery to be good because I have worked at it, not because I “just got lucky”!
The next was chipwork, which is just like chipwork in ordinary purl except for the added terror in case the silk wrapping comes off..
And then I got more practice with those nested loops, with the added adventure of adding shading as I went along.
Finally, there was more chipwork, and some little raised humps. These are made of purls stitched on like beads, but with a stitch slightly shorter than the length of purl chosen.
Again, these are not quite as consistent as I would like them to be, although I carefully used the ruler provided in the instructions to cut the lengths.
More practice needed!
I’ve felt the face was rather weak, so I decided to try again.
This time I needlefelted the padding underneath, to try to get the nose, the heavy brows, and the mouth in place.
Then I covered the padding that seemed the better with silk, and stitched the features again. In some ways, this is better than the first attempt, but it still looks a bit twisted. The eyes are certainly staring, but the nose isn’t straight.
In my defense, it became harder and harder to stitch, even though I began to feel that the shaped padding wasn’t shaped enough. Or even padded enough!
I think that before I attempt another version, I need to work out a way of keeping the silk under control while I add the features, without actually attaching it all the way around
In spite of that, I decided to attach this face in place of the last, and see whether I felt that a face “stuck on afterwards” would be a problem.
Well, no, I don’t think it is, although it’s hard to be sure. Not least, it involved removing still more of his headdress. That will need more padding to sit well with a more padded face.
I am sure that I need a new version, though. At present he looks like an apoplectic trumpeter, and that is not a good look for the Heretic Pharoah!
I’ve not written about the Colossus of Akhenaten for a while, but that isn’t to say I’ve stopped thinking about it. Unfortunately Akhenaten is proving obstreperous (as in life, so in embroidery…!)
I decided to try to sneak up on him by playing with details such as the crook and flail regalia.
I don’t want these to be couched to the fabric in bits, I want them to seem like miniaturised regalia, so I’m planning to thread various coloured purls onto wire and then poke the end of the wire through the fabric to the back.
This heavy purl – called “Rope” on the Golden Hinde website – seems to work perfectly for the crook, but single wire wasn’t strong enough to support it, so much of the experimentation was to get the right number of strands. I’m so glad I have proper goldwork scissors – the rope is tough and springy stuff.
You may recognise the materials in some of these experiments for the flail!
The two on the left use silk-covered purls in blue, with heavy gold pearl purl. The two on the right are coloured and gold purls, some of those used in the chipwork on the belt.
The potential handle is a gloriously stiff, over-the-top purled pearl purl in blue and silver, named something like “winter spiral”. I have my doubts about it in this context, because it’s silver rather than gold, but we’ll see…
I couldn’t resist trying the crook and flail trials in place.
I’m happy with the crook, but the flailing bits of the flail are giving trouble. None of the options really looks the right scale – the purls are too small, the pearl purl may be a bit too heavy, and the “winter spiral” handle doesn’t look quite right, either.
So I have some more thinking to do. Again…


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Who you gonna call? Lots of people are excited about the new Ghostbusters, starring an all-new cast of arguably the best comedians out there. But who stars alongside Leslie Jones, Melissa McCarthy, Kate McKinnon, and Kristen Wiig? A Cadillac!
That’s right. Just like in the classic 1984 version, the Cadillac is once again a star of the film. The original Ghostbusters features a classic 1959 Cadillac ambulance, lovingly called the Ecto-1. The director of the new movie, Paul Feig, wanted to keep that element of the original vehicle.
The new Ecto-1, aka “ectoplasm” (fictional ghost blood), definitely gives a nod to its predecessor. It’s a 1980’s Cadillac Fleetwood hearse, straight out of the Reagan-era!
“The minute I saw this mid-‘80’s Cadillac Fleetwood hearse, I thought, that’s it. I love the straight lines of those cars,” director Paul Feig said,” It looked cool and modern, while still old.”
It’ll keep the Ecto-1 name and bear the classic Ghostbusters symbol on the driver’s door. The car bears a fake New York license plate titled “Ecto-1” (because the real Ecto-1 plate is already on a Lexus in Long Island!) and an awesome ghost hood ornament.
There’s plenty more to love about it, just wait for the movie!


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Poe Statement On Capture Of Benghazi Terrorist--Ahmed Abu Khattala
Our elite Special Operations forces have located and captured one of the suspected ringleaders of the terrorist attack in Benghazi. Ahmed Abu Khattala was able to roam free for far too long, even conducting interviews with an American news outlet at a café in Benghazi. The failure to bring any of the killers to justice until now has made the United States appear weak and helped to advance the narrative that attacks against the United States will go unpunished.
Khattala’s capture and interrogation should shed light on what happened that night in Benghazi, as there is still much we don’t know. There are still other terrorists at large and they should also be brought to justice as soon as possible. Justice demands that we capture all of the outlaws, because justice is what we do in this country.


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New Year, 2001
I would like to govern my actions to benefit the quality of my life.
As loving and courteous at work I can be, I would like to become more of that at home. Once home, I sometimes shut down, feeling I’ve given my all to the day. I think I need more balance.
I would like to have a better relationship with my mother, and go on a trip with my daughter. I would like to attract a partner who is more attuned to some of the beliefs I hold dear to my heart.
Doing my Forever Biography has given me the opportunity to pay tribute to my past, and also to let it go. By letting go, I feel free to grow, trust, be, love. All the things that you need to create the life you would like to have. I had known that doing my biography would touch my life in some way, but I never dreamed to what extent. Some of it is joyful, some painful, but just stay with it. Trust the process. Release. This is truly a new year for me.

domain: literature


Stimulus Bill Funding, Congressional Recesses
Stimulus Bill Includes Billions for Natural Resource Agencies
Today the House and Senate are expected to pass an $789 billion economic stimulus package. The Land Trust Alliance has been engaged in this process from the very beginning, but clear Congressional and Administration guidelines from the outset made significant new funding for land conservation unlikely. That said, the final package does include over $15 billion for federal natural resource agencies, some of which may be of help to your land trust--if you act fast!
The Alliance worked with partners to support conservation funding in general, and we hope that land trusts will benefit from some of these programs:
$145 million to the Natural Resources Conservation Service for the purchase of easements on and restoration of flood-prone farmland--the clearest opportunity for land trusts to fund acquisition with this bill.
$230 million to the National Oceanic and Atmospheric Administration, $1 billion to the Bureau of Reclamation, $5 billion to the Corps of Engineers and another $195 million to NRCS, all available, at least in part, for watershed restoration, including projects like dam removal, wetlands restoration and fish ladders on private lands.
$250 million to the U.S. Forest Service for cooperative projects to benefit state and private lands, primarily hazardous fuels reduction and post-fire restoration.
$290 million to the U.S. Fish and Wildlife Service, $905 million to the National Park Service, $320 million to the Bureau of Land Management and another $950 million to the Forest Service, all nominally for projects on federal lands, but if your organization has properties adjacent to federal lands, there could be opportunities for partnerships on projects like habitat restoration and trail building.
At least 3% of the $27.5 billion in state transportation funding will go to Transportation Enhancement projects which can include acquisition of scenic or historic easements, trail building and environmental mitigation.
At least 20% of EPA's $6 billion in Safe Drinking Water Act funding will be available for unconventional water quality projects which have included land conservation in the past.
In every case, speed is of the essence! If you hope to benefit from this funding, you should call your local offices of these agencies today and get on their radar screen. Agencies are required to detail their plans within 30 days and obligate funds to specific projects within 90 days, so it's important to sell them on your priorities today.
Congressional Recesses: Town Halls Now, Site Visits in April
Between now and their adjournment in the fall, Members of Congress will spend ten weeks, and almost every weekend, back in their districts meeting with constituents like you. An in-district meeting is a great chance to meet with your Representative in a more casual environment and plant the seeds of a truly lasting relationship.
Next week is the President's Day recess, and while it may be too late to schedule an event, it's almost certain your Representative will be hosting several public events such as town hall meetings and pancake breakfasts. These are great opportunities to meet your Representative and ask him or her to become an original cosponsor of easement incentive legislation. To find out what events they're hosting, simply visit their page at www.house.gov, call your nearest district office, and ask.
The single best way to develop lasting relationships with your Members of Congress is to invite them out into the field to see the special places you're conserving and meet landowners benefiting from the easement incentive. Now is the time to invite them to a site visit over the Spring District Work Period, April 4-19. Visit our site visits webpage for step-by-step advice, a sample meeting request, media templates and a photo gallery of successful events.
Please don't hesitate to ask for advice, and please send photos of your event to firstname.lastname@example.org so we can add you to the gallery.
Thanks for helping! ...and a special thanks to the National Fish and Wildlife Foundation and America Bikes for these late-breaking stimulus numbers.


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Walking interventions focused on increasing step counts are typically associated with salutary effects on glycemia, fasting insulin, insulin resistance and blood lipids which may be in turn associated with improvements in cardiorespiratory fitness (peak oxygen uptake – VO2peak) and vascular stiffness. We hypothesized that a novel 4-month, behavioral economics-based walking intervention would have favorable effects on glucose homeostasis and blood lipids and that these in turn would be related to VO2peak and vascular stiffness (carotid femoral pulse wave velocity – cfPWV).
We carried out secondary analyses on a subsample of sedentary, overweight/obese adults who participated in a 4-month, 2x2, randomized-controlled walking intervention examining the effects of goal setting (static v. adaptive goals) and rewards (immediate v. delayed) on steps/day (N=96). Fasting blood samples (n=58) were collected from participants before and after the intervention. Premenopausal females were in the follicular phase of their menstrual cycles. Lipid and glucose levels were measured using an automated chemistry analyzer, while insulin was measured using radio-immunoassay. Homeostatic model of insulin resistance (HOMA-IR) was calculated using the following formula (HOMA-IR=glucose x insulin / 405). We examined associations [partial correlations (adjusted for age)] between changes in blood biomarkers and VO2peak and cfPWV, irrespective of group, and we used linear mixed models to examine between-group differences in levels of and change in biomarker outcomes.
Groups did not differ in overall levels of, or degree of change in, biomarker outcomes (all p>0.05). Mean changes, irrespective of group, in biomarkers were as follows: glucose Δ= 0.74± 4.5mg/dl; insulin Δ= 0.09 ± 4.1 µU/ml; total cholesterol Δ= 0.24 ± 20.6 mg/dl; HDL-C Δ= 0.27 ± 5.1 mg/dl; LDL-C Δ= 1.3 ± 19.9 mg/dl; triglycerides Δ= 1.7 ± 27.2 mg/dl; HOMA-IR Δ = -.0548 ± 1.05). We found no significant associations between change in biomarker levels and change in VO2peak or change in cfPWV (all correlation coefficients < 0.15; p > 0.05).
A 4-month, behavioral economics-based mHealth intervention focused on increasing steps/day did not bring about favorable changes on markers of glycemia, insulin resistance and blood lipids.
- Changes in Glycemia and Serum Lipids Following a 4-Month mHealth Walking Intervention

domain: health


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Hematopoietic stem cell (HSC) attrition is considered the key event underlying progressive bone marrow failure (BMF) in Fanconi anemia (FA), the most frequent inherited BMF disorder in humans. However, despite major advances, how the cellular, biochemical and molecular alterations reported in FA lead to HSC exhaustion remains poorly understood. Here, we demonstrated in human and mouse cells that loss-of-function of FANCA or FANCC, products of two genes affecting more than 80% of FA patients worldwide, is associated with constitutive expression of the transcription factor Microphthalmia (MiTF) through the cooperative, unscheduled activation of several stress signaling pathways, including the SMAD2/3, p38MAPK, NF-kB and AKT cascades. We validated the unrestrained Mitf expression downstream of p38 in Fanca-/- mice, which display hallmarks of hematopoietic stress, including loss of HSC quiescence, DNA damage accumulation in HSCs and reduced HSC repopulation capacity. Importantly, we demonstrated that shRNA-mediated downregulation of Mitf expression or inhibition of p38 signaling rescued HSC quiescence and prevented DNA damage accumulation. Our data support the hypothesis that HSC attrition in FA is the consequence of defects in the DNA damage response combined with chronic activation of otherwise transiently activated signaling pathways, which jointly prevent the recovery of HSC quiescence.
Alessia Oppezzo, Julie Bourseguin, Emilie Renaud, Patrycja Pawlikowska, Filippo Rosselli
Genomics of primary prostate cancer differs from that of metastatic castration-resistant prostate cancer (mCRPC). We studied genomic aberrations in primary prostate cancer biopsies from patients who developed mCRPC, also studying matching, same patient, diagnostic and mCRPC biopsies following treatment. We profiled 470 treatment-naïve, prostate cancer diagnostic biopsies and for 61 cases, mCRPC biopsies using targeted and low-pass whole genome sequencing (n = 52). Descriptive statistics were used to summarize mutation and copy number profile. Prevalence was compared using Fisher's exact test. Survival correlations were studied using log-rank test. TP53 (27%) and PTEN (12%) and DDR gene defects (BRCA2 7%; CDK12 5%; ATM 4%) were commonly detected. TP53, BRCA2, and CDK12 mutations were significantly commoner than described in the TCGA cohort. Patients with RB1 loss in the primary tumour had a worse prognosis. Among 61 men with matched hormone-naïve and mCRPC biopsies, differences were identified in AR, TP53, RB1, and PI3K/AKT mutational status between same-patient samples. In conclusion, the genomics of diagnostic prostatic biopsies acquired from men who develop mCRPC differs to that of the primary prostatic cancers. RB1/TP53/AR aberrations are enriched in later stages, but the prevalence of DDR defects in diagnostic samples is similar to mCRPC.
Joaquin Mateo, George Seed, Claudia Bertan, Pasquale Rescigno, David Dolling, Ines Figueiredo, Susana Miranda, Daniel Nava Rodrigues, Bora Gurel, Matthew Clarke, Mark Atkin, Rob Chandler, Carlo Messina, Semini Sumanasuriya, Diletta Bianchini, Maialen Barrero, Antonella Petremolo, Zafeiris Zafeiriou, Mariane Sousa Fontes, Raquel Perez-Lopez, Nina Tunariu, Ben A. Fulton, Robert Jones, Ursula B. McGovern, Christy Ralph, Mohini Varughese, Omi Parikh, Suneil Jain, Tony Elliott, Shahneen Sandhu, Nuria Porta, Emma Hall, Wei Yuan, Suzanne Carreira, Johann S. de Bono
Aberrant Tau inclusions in the locus coeruleus (LC) are the earliest detectable Alzheimer’s disease–like (AD-like) neuropathology in the human brain. However, why LC neurons are selectively vulnerable to developing early Tau pathology and degenerating later in disease and whether the LC might seed the stereotypical spread of Tau pathology to the rest of the brain remain unclear. Here, we show that 3,4-dihydroxyphenylglycolaldehyde, which is produced exclusively in noradrenergic neurons by monoamine oxidase A metabolism of norepinephrine, activated asparagine endopeptidase that cleaved Tau at residue N368 into aggregation- and propagation-prone forms, thus leading to LC degeneration and the spread of Tau pathology. Activation of asparagine endopeptidase–cleaved Tau aggregation in vitro and in intact cells was triggered by 3,4-dihydroxyphenylglycolaldehyde, resulting in LC neurotoxicity and propagation of pathology to the forebrain. Thus, our findings reveal that norepinephrine metabolism and Tau cleavage represent the specific molecular mechanism underlying the selective vulnerability of LC neurons in AD.
Seong Su Kang, Xia Liu, Eun Hee Ahn, Jie Xiang, Fredric P. Manfredsson, Xifei Yang, Hongbo R. Luo, L. Cameron Liles, David Weinshenker, Keqiang Ye
The c-MYC (MYC) oncoprotein is often overexpressed in human breast cancer; however, its role in driving disease phenotypes is poorly understood. Here, we investigate the role of MYC in HER2+ disease, examining the relationship between HER2 expression and MYC phosphorylation in HER2+ patient tumors and characterizing the functional effects of deregulating MYC expression in the murine NeuNT model of amplified-HER2 breast cancer. Deregulated MYC alone was not tumorigenic, but coexpression with NeuNT resulted in increased MYC Ser62 phosphorylation and accelerated tumorigenesis. The resulting tumors were metastatic and associated with decreased survival compared with NeuNT alone. MYC;NeuNT tumors had increased intertumoral heterogeneity including a subtype of tumors not observed in NeuNT tumors, which showed distinct metaplastic histology and worse survival. The distinct subtypes of MYC;NeuNT tumors match existing subtypes of amplified-HER2, estrogen receptor–negative human tumors by molecular expression, identifying the preclinical utility of this murine model to interrogate subtype-specific differences in amplified-HER2 breast cancer. We show that these subtypes have differential sensitivity to clinical HER2/EGFR–targeted therapeutics, but small-molecule activators of PP2A, the phosphatase that regulates MYC Ser62 phosphorylation, circumvents these subtype-specific differences and ubiquitously suppresses tumor growth, demonstrating the therapeutic utility of this approach in targeting deregulated MYC breast cancers.
Tyler Risom, Xiaoyan Wang, Juan Liang, Xiaoli Zhang, Carl Pelz, Lydia G. Campbell, Jenny Eng, Koei Chin, Caroline Farrington, Goutham Narla, Ellen M. Langer, Xiao-Xin Sun, Yulong Su, Colin J. Daniel, Mu-Shui Dai, Christiane V. Löhr, Rosalie C. Sears
Neuronal hyperexcitability and cytoplasmic mislocalization of the nuclear RNA binding proteinTDP43 are universal features in amyotrophic lateral sclerosis (ALS), but the relationship between these phenomena remains poorly defined. Here, we show that neuronal hyperexcitability drives TDP43 pathology by upregulating shortened (s)TDP43 splice variants missing the canonical C-terminus. sTDP43 isoforms preferentially accumulate in the cytoplasm,forming insoluble inclusions that sequester full-length TDP43 via preserved N-terminal interactions. Consistent with these findings, sTDP43 overexpression is highly toxic to mammalian neurons, suggesting that neurodegeneration results from complementary gain- and loss-of-function mechanisms. In humans and mice, sTDP43 transcripts are significantly enriched in vulnerable motor neurons, and we observed a striking accumulation of sTDP43 protein within neurons and glia of ALS patients. These studies uncover a hitherto unknown role of alternative TDP43 splice isoforms in ALS, and indicate that sTDP43 production may be a key contributor to the susceptibility of motor neurons in ALS.
Kaitlin Weskamp, Elizabeth M. Tank, Roberto Miguez, Jonathon P. McBride, Nicolás B. Gómez, Matthew White, Ziqiang Lin, Carmen Moreno Gonzalez, Andrea Serio, Jemeen Sreedharan, Sami J. Barmada
CD8 cytotoxic T lymphocytes (CTLs) rely on rapid reorganization of the branched F-actin network to drive the polarized secretion of lytic granules, initiating target cell death during the adaptive immune response. Branched F-actin is generated by the nucleation factor actin-related protein 2/3 (Arp2/3) complex. Patients with mutations in the actin-related protein complex 1B (ARPC1B) subunit of Arp2/3 show combined immunodeficiency, with symptoms of immune dysregulation, including recurrent viral infections and reduced CD8+ T cell count. Here, we show that loss of ARPC1B led to loss of CTL cytotoxicity, with the defect arising at 2 different levels. First, ARPC1B is required for lamellipodia formation, cell migration, and actin reorganization across the immune synapse. Second, we found that ARPC1B is indispensable for the maintenance of TCR, CD8, and GLUT1 membrane proteins at the plasma membrane of CTLs, as recycling via the retromer and WASH complexes was impaired in the absence of ARPC1B. Loss of TCR, CD8, and GLUT1 gave rise to defects in T cell signaling and proliferation upon antigen stimulation of ARPC1B-deficient CTLs, leading to a progressive loss of CD8+ T cells. This triggered an activation-induced immunodeficiency of CTL activity in ARPC1B-deficient patients, which could explain the susceptibility to severe and prolonged viral infections.
Lyra O. Randzavola, Katharina Strege, Marie Juzans, Yukako Asano, Jane C. Stinchcombe, Christian M. Gawden-Bone, Matthew N.J. Seaman, Taco W. Kuijpers, Gillian M. Griffiths
Hereditary hemorrhagic telangiectasia (HHT), a genetic bleeding disorder leading to systemic arteriovenous malformations (AVMs), is caused by loss-of-function mutations in the ALK1-ENG-Smad1/5/8 pathway. Evidence suggests that HHT pathogenesis strongly relies on overactivated PI3K-Akt-mTOR and VEGFR2 pathways in endothelial cells (ECs). In the BMP9/10-immunoblocked (BMP9/10ib) neonatal mouse model of HHT, we report here that the mTOR inhibitor, sirolimus, and the receptor tyrosine-kinase inhibitor, nintedanib, could synergistically fully block, but also reversed, retinal AVMs to avert retinal bleeding and anemia. Sirolimus plus nintedanib prevented vascular pathology in the oral mucosa, lungs, and liver of the BMP9/10ib mice, as well as significantly reduced gastrointestinal bleeding and anemia in inducible ALK1-deficient adult mice. Mechanistically, in vivo in BMP9/10ib mouse ECs, sirolimus and nintedanib blocked the overactivation of mTOR and VEGFR2, respectively. Furthermore, we found that sirolimus activated ALK2-mediated Smad1/5/8 signaling in primary ECs—including in HHT patient blood outgrowth ECs—and partially rescued Smad1/5/8 activity in vivo in BMP9/10ib mouse ECs. These data demonstrate that the combined correction of endothelial Smad1/5/8, mTOR, and VEGFR2 pathways opposes HHT pathogenesis. Repurposing of sirolimus plus nintedanib might provide therapeutic benefit in HHT patients.
Santiago Ruiz, Haitian Zhao, Pallavi Chandakkar, Julien Papoin, Hyunwoo Choi, Aya Nomura-Kitabayashi, Radhika Patel, Matthew Gillen, Li Diao, Prodyot K. Chatterjee, Mingzhu He, Yousef Al-Abed, Ping Wang, Christine N. Metz, S. Paul Oh, Lionel Blanc, Fabien Campagne, Philippe Marambaud
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR), with approximately 90% of patients harboring at least one copy of the disease-associated variant F508del. We utilized a yeast phenomic system to identify genetic modifiers of F508del-CFTR biogenesis, from which ribosomal protein L12 (RPL12/uL11) emerged as a molecular target. In the present study, we investigated mechanism(s) by which suppression of RPL12 rescues F508del protein synthesis and activity. Using ribosome profiling, we found that rates of translation initiation and elongation were markedly slowed by RPL12 silencing. However, proteolytic stability and patch-clamp assays revealed RPL12 depletion significantly increased F508del-CFTR steady-state expression, interdomain assembly, and baseline open-channel probability. We next evaluated whether Rpl12-corrected F508del-CFTR could be further enhanced with concomitant pharmacologic repair (e.g., using clinically approved modulators lumacaftor and tezacaftor) and demonstrated additivity of these treatments. Rpl12 knockdown also partially restored maturation of specific CFTR variants in addition to F508del, and WT Cftr biogenesis was enhanced in the pancreas, colon, and ileum of Rpl12 haplosufficient mice. Modulation of ribosome velocity therefore represents a robust method for understanding both CF pathogenesis and therapeutic response.
Kathryn E. Oliver, Robert Rauscher, Marjolein Mijnders, Wei Wang, Matthew J. Wolpert, Jessica Maya, Carleen M. Sabusap, Robert A. Kesterson, Kevin L. Kirk, Andras Rab, Ineke Braakman, Jeong S. Hong, John L. Hartman IV, Zoya Ignatova, Eric J. Sorscher
Fibronectin in the vascular wall promotes inflammatory activation of the endothelium during vascular remodeling and atherosclerosis. These effects are mediated in part by fibronectin binding to integrin α5, which recruits and activates phosphodiesterase 4D5 (PDE4D5) by inducing its dephosphorylation on an inhibitory site Ser651. Active PDE then hydrolyzes anti-inflammatory cAMP to facilitate inflammatory signaling. To test this model in vivo, we mutated the integrin binding site in PDE4D5 in mice. This mutation reduced endothelial inflammatory activation in athero-prone regions of arteries, and, in a hyperlipidemia model, reduced atherosclerotic plaque size while increasing markers of plaque stability. We then investigated the mechanism of PDE4D5 activation. Proteomics identified the PP2A regulatory subunit B55α as the factor recruiting PP2A to PDE4D5. The B55α-PP2A complex localized to adhesions and directly dephosphorylated PDE4D5. This interaction also unexpectedly stabilized the PP2A-B55α complex. The integrin-regulated, pro-atherosclerotic transcription factor Yap is also dephosphorylated and activated through this pathway. PDE4D5 therefore mediates matrix-specific regulation of EC phenotype via an unconventional adapter role, assembling and anchoring a multifunctional PP2A complex with other targets. These results are likely to have widespread consequences for control of cell function by integrins.
Sanguk Yun, Rui Hu, Melanie E. Schwaemmle, Alexander N. Scherer, Zhenwu Zhuang, Anthony J. Koleske, David C. Pallas, Martin A. Schwartz
Deciphering novel pathways regulating liver lipid content has profound implications for understanding the pathophysiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Recent evidence suggests that the nuclear envelope is a site of regulation of lipid metabolism but there is limited appreciation of the responsible mechanisms and molecular components within this organelle. We showed that conditional hepatocyte deletion of the inner nuclear membrane protein lamina-associated polypeptide 1 (LAP1) caused defective VLDL secretion and steatosis, including intranuclear lipid accumulation. LAP1 binds to and activates torsinA, an AAA+ ATPase that resides in the perinuclear space and continuous main ER. Deletion of torsinA from mouse hepatocytes caused even greater reductions in VLDL secretion and profound steatosis. Both of these mutant mouse lines developed hepatic steatosis and subsequent steatohepatitis on a regular chow diet in the absence of whole-body insulin resistance or obesity. Our results establish an essential role for the nuclear envelope-localized torsinA-LAP1 complex in hepatic VLDL secretion and suggest that the torsinA pathway participates in the pathophysiology of nonalcoholic fatty liver disease.
Ji-Yeon Shin, Antonio Hernandez-Ono, Tatyana Fedotova, Cecilia Östlund, Michael J. Lee, Sarah B. Gibeley, Chun-Chi Liang, William T. Dauer, Henry N. Ginsberg, Howard J. Worman
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text:
share all Heaven's eternal joys,
And be forever blessed.
Passing the Gate.
Lines on leaving the house of a dear friend where I had
pleasantly spent several weeks.
Down deep in the heart is a fountain of tears,
Though seldom it flows to the eye;
'Tis not that I have not true interest and love,
That I say not the sad words, Good bye.
The gate must be opened, and opened for me,
For me to go out of the place,
Where I have enjoyed the best bounties of earth,
Where in love face has answered to face.
As I passed through the gate, language fails to express
My deep-felt emotions of heart;
'Twas leaving a home where was freedom and rest;
And who else can such favors impart?
Not that I was homeless; another dear place
Was all ready and waiting me, where
Again I should mingle with children and friends;
But oh! there's life's burden and care.
'Tis not that I'd shun them, and useless remain,
That I felt thus whi
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domain: library


FlexTrade Systems has announced the incorporation of artificial intelligence (AI) technology into its multi-asset solution, FlexTRADER EMS. FlexA, a voice-activated application created by FlexTrade’s data science team, is designed to revolutionise the interaction between traders and their technology platform by applying natural language to parse and control the solution through voice commands or a text-based chat interface.
This innovative application allows traders to easily handle vast amounts of information beyond the traditional 2D grid visualisation and input devices. FlexA enables users to gain an in-depth understanding of orders, request tailored reports on historical trading with specific visual formats, and automate actions to accelerate workflow. This launch signifies one of the first practical applications of AI technology directly within an OEMS solution, according to the company.
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text:
I made this ant using a few balloons, last year. It stayed inflated for two days, and lost lot of weight on the third day. I am not sure what happened after that as I could not find it on my table where I had left it before I left for school.
- Lamp kolam
- Valentine rangoli
- Butterfly - Perler beads
- Rangoli windows
- Clay creations - grandma and grandpa
Dotted rangoli. Dots: 8x8. My rangoli has hearts in it. I have used color pencils to color the rangoli.
I had made this dotted kolam at my grandpa's house in Sirkazhi, up on the terrace during the winter holidays. There are 6 rows of dots, and each row has 6 dots.
I made my valentine card with a heart in the center. I used red rangoli powder to color it in, and drew two hearts on either sides. I used pink sugar crystals to color my pink hearts!
Last year, I had made some butterflies using a Perler bead kit. I had also made a couple of dogs. Perler bead kits come with a plastic base, in many shapes, and colorful bead kits. There is a piece of special paper included in the kit. We arrange the beads on the plastic base, and the beads are fused into place by placing the piece of paper on top and ironing it for a few seconds. The shape is then left to cool, undisturbed, and is then ready to be displayed.
Here are two of my rangoli windows that I made using paper. I save my paper-windows in books, so they don't get crumpled.
Last year, I made these faces of grandma and grandpa, using clay.
This is the rangoli I made for Krishnajayanthi. I finished it at about 7:30 pm and it was a sunny evening. While taking a picture, we could not avoid the shadow of a banner falling in the middle of my rangoli. Yellow is my favorite color. I hope you like my small rangoli.

domain: design


text:
The Rightly-Guided Caliphs by Tughra Books at Cmc Schools. Hurry! Limited time offer. Offer valid only while supplies last. This book explores for the children the life of the first four Caliphs after Prophet Muhammad. Each one of the Rightly-Guided Caliphs was a paragon of virtue. What made them great as not their political power but the power of their faith. Every anecdote in their lives tells a different parable. This book features selections from their lives both during the life of the Prophet and during their subsequent caliphate..
Have questions about this item, or would like to inquire about a custom or bulk order?
If you have any questions about this product, contact us by completing and submitting the form below. If you are looking for a specif part number, please include it with your message.
By Rummana Publishing Inc
mpn: 43241-1293, ean: 9780999061008, isbn: 0999061003,
By Religious and Moral Education Press
ean: 9781851752065, isbn: 1851752064,


text:
A man in Incheon, South Korea, who tricked fans into handing over their money in exchange for Wanna One concert tickets has recently been arrested by authorities.
He was sentenced to a two-year prison sentence on probation along with 120 hours of community service.
According to police reports, the culprit has been scamming Wanna One fans since last year September. But the most shocking part of the whole crime was how easily it was done.
The culprit simply tweeted on Twitter saying that he would give tickets to a Wanna One concert if payment was transferred into a designated bank account. A total of 45 people fell for the scam. Two of the victims lost nearly $1500 each.


text:
Lauren feels their business is only as strong as the communities they serve. Her purpose is to have a constructive impact on the communities in which they live and do business. Lauren Forbes Group contributes continually to various charities and organizations in the South Bay. Charities we have recently provided donations to include Manhattan Beach Education Foundation, American Martyrs, Pacific School, Robinson School, Grandview School, Hermosa Beach Little League, and more. Our focus charities/foundations are NextStep Fitness, Freedom 4 U and P.S. I Love You. Lauren serve on the boards of these respective foundations and are committed to making a difference there.
NEXT STEP FITNESS
NextStep Fitness is a nonprofit that provides people living with paralysis the opportunity for health and recovery through affordable and progressive community fitness and wellness facilities. NextStep has paved the way with the first community facility in the U.S. to offer Locomotor and activity based training at its state of the art facility in Los Angeles, and it continues its vision to expand across the United States. The organization’s other initiatives are participation in cutting edge research, education, and awareness programs that are focused on enhancing the lives of the 6 million people in the U.S. living with paralysis. In addition to being a general supporter of the cause, Lauren is an acting board member of NextStep and avid participant in fundraising activities.
FREEDOM 4 U
Freedom 4 U was founded in 2000 by Greg Allen when he started to think about teens’ social needs – their need to gather and express themselves with their peers. He looked at his community and noticed that teens were meeting at house parties where in many instances there was drinking, drugs and other risky behaviors. As Greg interacted with several parents, school personnel and law enforcement; it became clear that the community needed safe, supervised gatherings. It was also clear that it needed to be youth driven in terms of ideas and implementation. To further validate his assumptions, he created a survey that went out to several teens in the community. He discovered that the first thing teens want is to be with their friends and that music and art was something they would gather around as a focus. Greg realized he needed to create something that teens would buy into through attendance and participation. He wanted to reduce the risky behaviors of as many teens as possible and develop their talent and abilities through safe, creative, supervised, group activities.
P.S. I LOVE YOU
P.S. I Love You was founded in 1998 by Patricia Scelza-Jones, an associate with Lauren Forbes Group. The creation of this foundation was inspired by Patricia’s compassion and empathy to make a difference in the lives of others in need. She realized that the contribution she could make was as simple as sharing the spirit of giving. There are many obstacles facing children today -- especially children in low-income communities. These include poverty, low self esteem, loss of self-control and focus, alcohol and drug abuse, gang violence, lack of quality nutrition, obesity, and single parent/broken families. These, and many other types of hurdles, can prevent a child from reaching his or her full potential.
We, at P.S. I Love You Foundation, believe if children develop strong emotional, physical and social well-being skills early in life, this can reduce the chances of - and perhaps prevent – these children from growing up depressed, violent, turning to gangs for support, dropping out of school, or using drugs to cope. P.S. I Love You’s goal is to empower and inspire these children by teaching skills to help them in their everyday lives, to reduce stress, to influence successful individuals and help them develop healthy minds, positive attitudes and strong bodies. A portion of every real estate deal Patricia participates in is contributed to the P.S. I Love You Foundation.
We provide the highest level of sales expertise, exceptional service and experience to the luxury and multi-unit South Bay residential marketplace. Lauren Forbes Group is the leading real estate team in the South Bay with over 60 years of combined experience and a team well versed in executing complex real estate transactions.Contact Us


Jomarie Wasik was sworn in by Mayor Jackson in April of 2006 as the Director of Public Service. In January of 2011, as a result of reorganization, she now holds the position of Director of the newly formed Mayor’s Office of Capital Projects. She provides oversight of major public improvement projects with an annual capital budget of $110 million. It is her job to assure that the city’s major projects are delivered with high quality, on time and within budget.
Director Wasik extends a prolific civic career with the City of Cleveland. The first woman to control the Department of Public Service, Wasik has worked for the city since 1988. She began her work with the City of Cleveland that year as a Surveyor and was promoted to Chief Surveyor in 1991. In 1998, she was appointed Acting Commissioner of Engineering and Construction where she provided oversight of major road and bridge construction, prepared designs, plans, and specifications, and provided estimates of capital improvement costs and related services.
The following year, Wasik was named Administrator of Engineering and Planning, maintaining many of the duties she had while Acting Commissioner. In 2002, she was named Assistant Director of the Department of Public Service and assumed additional oversight and management responsibilities.
Before entering the public sector, Wasik was a Civil Designer with URS Consultants. As such, she prepared construction documents and site plans, performed related computations, drafted survey plats, and prepared legal descriptions for a variety of architectural and engineering projects.
Wasik is a board member of the American Public Works Association, a Past President of the Cleveland Chapter of Professional Land Surveyors of Ohio and was named the 2002 Surveyor of the Year. She is a 2001 graduate of the Cleveland State University Leadership Academy.
Wasik received her A.A.S. degrees in drafting and design technology, as well as in construction technology, from Stark Technical College in Canton, Ohio. She has been a registered land surveyor since 1985.
We are committed to improving the quality of life in the City of Cleveland by strengthening our neighborhoods, delivering superior services, embracing the diversity of our citizens, and making Cleveland a desirable, safe city in which to live, work, raise a family, shop, study, play and grow old.