Talia Cotton departs Pentagram to launch Cotton, an agency specifically for coding and design
Spotting a “catch-22” around coding in design, Cotton Design is ushering in a dedicated space for the medium to illustrate its potential.
- Liz Gorny
- 16 February 2023
In Talia Cotton’s time at Pentagram, she lead on data-driven and algorithmic brand identities and websites, with a number of her projects hinged on pushing what was possible with design through coding. With access to such impactful projects, starting a new company “was never an option”, says the designer. Yet, at the same time, Talia was witnessing how coding was received in the industry. It's received with curiosity because of its “potential impact”, but frustration too, with many not knowing “how to get there or even what’s possible”. Cotton is Talia’s answer to this issue: a new agency situated at the intersection between design and code.
Talia hopes the company will work to close the gap between the two mediums at a few points. Firstly, the company will serve as a home for designers who love to code, in a time when “more and more designers are graduating with the basic knowledge – and passion – for how to code”. Secondly, Talia wants Cotton to be a collaborator for agencies who aren’t currently working with the medium, or at its fullest potential.
Talia says there is a catch-22 in the design industry’s uptake of technology like coding. Despite the increase in those with coding skills and the uptick in digital-first companies, agencies have been slower to embrace it. Talia explains why this might be: “Firstly and most importantly, their code-less processes work and have worked for decades. (And if it ain’t broke..!). But secondly, for those agencies and design leads who have that curiosity for the exciting potentials of coding, many design leaders simply don’t have the background to understand how to guide those projects; it’s a skill that takes years of exposure to become an expert at.”
Cotton launches with a new website and campaign which, of course, needed to demonstrate the goods, showing people “the infinite number of ways” coding can be used as a tool to enhance design. The identity also does something to counter the preconception that coding is intimidating and better off not bothered with as a result. It features interactive typographic treatments of Cotton, including a Tetris and balloon-based iteration. Talia tells us there are 20 treatments in all that will be released gradually. “We did this to firstly show off the many different ways a brand or design can successfully be made digital and, secondly, to show off,” she jokes.
When we ask Talia the kinds of projects Cotton hopes to welcome in its first year, she points towards branding: “that’s where my experience – and fascination – exists”. The capabilities of the agency also allows for new scope in the field, where coding offers untapped benefits.
For example, this could be applied when a brand is technology driven. “Instead of using the overused tropes of pixels and monospaced typefaces, you can use technology itself to illustrate technology,” Talia poses. Or, when the brand has a "complex abstract theme that is hard to represent with colour and typography alone”, technology might provide new ways address it, “resulting in design that is simply more authentic".
Talia Cotton: Cotton Design (Copyright © Cotton Design, 2023)
About the Author
Liz (she/they) joined It’s Nice That as news writer in December 2021. After graduating in Film from The University of Bristol, they worked freelance, writing for independent publications such as Little White Lies, INDIE magazine and design studio Evermade.


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Have you been experiencing pain or discomfort that has been affecting your daily life? Perhaps you have considered seeing a physical therapist, but you’re not sure if you need a referral from your doctor.
This is a question that many people face when seeking out physical therapy services. While some insurance plans require referrals for coverage, it’s important to know that in many cases, you can see a physical therapist without one.
“Physical therapists are experts in diagnosing and treating movement disorders,” says the American Physical Therapy Association. “They help individuals reduce pain, improve mobility, prevent injuries and impairments, and optimize overall health and well-being.”
Whether you’re recovering from an injury, managing a chronic condition, or simply looking to improve your quality of life, physical therapy could be just what you need. In this article, we will explore the circumstances under which you might need a referral to see a physical therapist, as well as common reasons for seeking out these services.
We’ll also discuss the benefits of physical therapy and what to expect during your first appointment. So why wait? Let’s dive in and discover how physical therapy could help you feel better today.
Yes, You Can: Direct Access
If you’re experiencing pain or discomfort in your body, it’s important to seek help from a medical professional. In many cases, people turn to physical therapists for assistance with joint or muscle pains, chronic conditions, and sports-related injuries. However, accessing this care can be difficult if you need a referral from a doctor. Fortunately, there is another option: direct access.
What is Direct Access?
Direct access allows patients to visit a physical therapist without first obtaining a referral from their primary care physician. This means that you don’t have to wait for an appointment with your doctor just to get the necessary paperwork to see a physical therapist. Instead, you can reach out directly to a licensed therapist and schedule a session based on your own needs and preferences.
It’s important to note, however, that direct access laws vary by state. Depending on where you live, you may only be able to see a physical therapist without a referral for a limited number of visits or for certain conditions. Additionally, some insurance plans may require a referral even if it isn’t mandated by state law. Before seeking out a physical therapist using direct access, be sure to research the laws in your area and check with your insurance company to understand your coverage.
What are the Benefits of Direct Access?
There are several benefits to using direct access to see a physical therapist:
- Quicker care: With direct access, you can bypass the time-consuming process of seeing your primary care doctor before being referred to a physical therapist. This means that you can get treatment faster and start managing your symptoms sooner.
- Fewer costs: By eliminating the need for a referral, you may also save money on copays and other expenses associated with primary care visits. This can be especially helpful if you need ongoing physical therapy sessions.
- Better outcomes: Seeing a physical therapist early on in the course of your condition or injury may lead to better results over time. By receiving preventative and rehabilitative care sooner rather than later, you may be able to speed up your recovery process and reduce the likelihood of complications later on.
How Do I Find a Physical Therapist for Direct Access?
If direct access is legal and beneficial in your state, the next step is to find a licensed physical therapist to work with. Here are some tips to help you get started:
- Check with your insurance company: Start by contacting your health insurance provider to see if they cover physical therapy without a referral. If so, they may have a directory of in-network providers that you can use as a starting point.
- Do some research: You can also search online for licensed physical therapists in your area who offer direct access services. Be sure to check reviews and testimonials from past clients to get an idea of their experience and success rate.
- Ask for recommendations: Consider reaching out to family members, friends, or coworkers who have sought out physical therapy in the past. They may be able to recommend someone they had a positive experience working with or warn you away from any negative experiences they’ve had.
Once you’ve identified a potential physical therapist to work with, call their office to verify that they offer direct access and schedule an appointment that works for you. During your first visit, be prepared to discuss your medical history, symptoms, and goals for treatment. From there, your therapist will create a personalized plan of care designed to help you overcome your concerns and achieve optimal wellness.
Direct access can be a helpful alternative to traditional referral-based physical therapy. If you’re experiencing pain or discomfort and want to explore your options for care, consider reaching out directly to a licensed physical therapist in your area.
What is Direct Access?
Direct Access is the ability to seek healthcare services without a referral from another healthcare provider. This means that patients can go directly to physical therapists for treatment of musculoskeletal problems. In the past, some insurance companies required patients to have a doctor’s referral before they would pay for physical therapy visits.
This has changed in recent years with most states allowing direct access to physical therapy services. Patients who do not have an established relationship with a primary care physician or specialist may find it easier and more cost-effective to see a physical therapist first.
Improved Patient Experience
The ability to access healthcare services quickly and easily is important to many people. With Direct Access, patients no longer have to wait weeks or months for a referral appointment. They can typically be seen by a physical therapist within a few days of calling to schedule an appointment.
Additionally, patients can choose which physical therapy practice they want to visit rather than being assigned to one by their healthcare provider. This allows them to select a practice that is convenient and meets their personal needs.
“Patients reported high satisfaction with direct access entry, citing increased control over health care decisions, ease of seeking care, timeliness, convenience, and saved time and money.” -National Center for Biotechnology Information (NCBI)
Reduced Healthcare Costs
Direct Access to physical therapy services can save patients money on healthcare costs. By eliminating the need for a referral, patients can avoid paying additional co-pays associated with seeing a primary care physician or specialist. Additionally, patients who are treated earlier with physical therapy may require fewer overall treatments, which reduces healthcare expenses.
“Physical therapists are equipped to diagnose and treat a range of conditions safely and effectively…This concludes that earlier physical therapy utilization by patients demonstrates significant costs savings when compared to those who are seen later in their episode of care.” -American Physical Therapy Association (APTA)
Increased Access to Care
Direct Access increases access to physical therapy services for patients. This is especially important for patients in rural or underserved areas who may have limited access to healthcare providers. Patients who live far from a physician’s office can still access physical therapy services close to home without traveling long distances.
“One reason that direct access laws were passed was due to studies showing many Americans live in counties without an adequate supply of primary care physicians and, thus, relying on referrals may prevent them from receiving necessary health care… Having fewer barriers to accessing outpatient therapy may help narrow this chasm.” -Rehabilitation Nursing Journal
Streamlined Referral Process
For patients who still prefer to see a doctor first, Direct Access can streamline the referral process. With Direct Access, patients can receive evaluation and treatment faster while having open communication between themselves, therapist, and physician. Some practices will refer patients back to their referring provider if they require medication management or additional interventions such as surgery after their evaluation.
“Previous studies indicate that eligible individuals underutilize recommended rehabilitation services…Results suggest that early initiation of targeted rehabilitative services should be considered a viable alternative to physician-directed care in select clinical populations.” -Journal of Occupational Rehabilitation
- It allows for improved patient experience, reduced healthcare costs, increased access to care, and a streamlined referral process.
- To take advantage of these benefits, it’s essential to check with your state board of physical therapy to determine any individual state regulations/regulations specific to your insurance, and if Direct Access is allowed in your area.
What are the Benefits of Direct Access?
One major benefit of direct access is that it allows patients to receive treatment more quickly. In traditional healthcare systems, patients often have to wait weeks or even months to see a specialist.
With direct access, patients can bypass this delay and schedule appointments directly with their physical therapist. This means they can get started with their treatment sooner rather than later, which can lead to faster recovery times and better overall outcomes.
“Direct access greatly improves patient satisfaction by allowing them to initiate care promptly.” -American Physical Therapy Association
Reduced Healthcare Costs
Another key advantage of direct access is that it can help reduce healthcare costs for both patients and providers. By skipping the referral step, patients save money on copays and other out-of-pocket expenses associated with doctor visits.
In addition, since physical therapists typically charge less per visit than medical doctors do, insurers may also be able to save money by covering therapy directly instead of through referrals. This ultimately benefits everyone involved in the healthcare system.
“Expanding direct access to physical therapy has the potential to lower healthcare costs while maintaining high-quality care.” -Health Affairs Blog
Increased Patient Autonomy
Lastly, direct access gives patients greater control over their own healthcare decisions. Instead of having to rely solely on their primary care physician’s recommendations, patients can choose to see a physical therapist whenever they feel it is necessary.
This allows patients to take a more proactive role in managing their health and wellness, which can lead to better long-term outcomes. It also ensures that patients always have access to the care they need, regardless of how busy their primary care provider may be.
“Direct access empowers patients with the ability to manage their own health and well-being.” -Cleveland ClinicOverall, direct access can provide a number of benefits for patients, including quicker treatment, reduced healthcare costs, and increased autonomy. By considering these advantages, patients may be able to make more informed decisions about their healthcare options and achieve better overall outcomes.
What Conditions Can Be Treated with Direct Access?
Back and Neck Pain
If you are experiencing back or neck pain, seeking help from a physical therapist through direct access can be incredibly beneficial. Physical therapists can provide non-invasive treatment options that may include manual therapy, stretching and strengthening exercises, and postural education.
Direct access to physical therapy for back and neck pain has been shown to have positive outcomes and reduce the need for more aggressive interventions such as surgery or opioid medications.
“Physical therapy is an effective option in many cases of acute or chronic back pain, particularly when paired with other treatments such as heat, ice, massage, and/or pain medication.” -Spine-Health
Athletes at all levels often experience injuries due to their athletic endeavors. Many times these injuries can benefit from early intervention through physical therapy.
Most PTs receive training in sports medicine, which means they are able to diagnose and treat a wide range of sport-related conditions. Some common sports injuries treated by physical therapists include sprains, strains, dislocations, and fractures.
Joint pain can severely impact your mobility and quality of life. If left untreated, it can lead to further complications and limitations.
Direct access to physical therapy provides individuals suffering from joint pain with a way to manage and alleviate symptoms. Treatment options may include exercise programs designed to increase strength and flexibility, joint mobilization techniques, and modalities like heat and cold therapy to decrease inflammation and pain.
“The benefits of physical therapy on joint pain likely stem from its ability to reduce inflammation, improve circulation and blood flow, and build strength in areas supporting damaged joints.” -Arthritis Foundation
If you have recently undergone surgery, physical therapy can be an integral part of your recovery process. Through direct access, you can begin working with a PT as soon as possible to regain mobility and prevent further complications.
Physical therapists are trained to work closely with many surgical specialties to help patients regain strength and function in the affected areas. Treatment may include exercise programs, manual techniques like stretching and massage, and modalities like electrical stimulation or ultrasound to improve healing times.
“Studies demonstrate that physical therapy following certain operations improves outcomes such as walking ability, climbing stairs, bending, and lifting.” -American Physical Therapy AssociationOverall, direct access to physical therapy offers individuals suffering from a variety of conditions the opportunity to seek out care without waiting for a referral from another provider. By seeking early intervention through direct access, patients can often shorten their recovery time and reduce the need for more invasive treatments down the line.
How Do I Find a Physical Therapist for Direct Access?
Ask Your Primary Care Physician
The first step to finding a physical therapist for direct access is by asking your primary care physician. Often, they can refer you to a trustworthy and reliable physical therapist in the area. Also, it’s essential to ask them if seeing a physical therapist is necessary and will help your condition.
Your primary care physician knows about your medical history, so they should be able to recommend a physical therapist based on your needs, goals, and any relevant information. If you’re looking to save more money or are unable to use direct access in your state, your primary doctor might not suggest seeing a physical therapist without a referral.
“Asking your primary care physician can give you peace of mind knowing you’ve received proper medical advice and referred to a qualified professional.”
Search Online Directories
You can find a physical therapist for direct access by searching online directories such as Healthgrades, ZocDoc, Medicare.gov, and Yelp. These websites allow patients to search and review healthcare providers’ profiles, including their credentials, experiences, locations, and specialties. It’s also important to check what kind of insurances they accept and what payment options are available.
To narrow down your search, consider filtering by location or specialty areas such as sports medicine, orthopedics, neurology, pediatrics, etc. This will ensure that the physical therapist you reach out to has experience with treating patients with similar conditions or injuries to yours.
“Online directories provide a convenient way for patients to research medical professionals and determine which one would best suit their needs.”
Check with Your Health Insurance Provider
If you have health insurance, checking with your provider can also help you find a physical therapist for direct access. Many insurers have online directories that list healthcare providers who accept their insurance plan. This is particularly helpful if your insurance covers most of the cost, or if they require pre-approval before paying for services.
Therapy coverage may vary by insurer, so it’s always best to check with them directly and ask about any out-of-pocket expenses you’ll be expected to pay.
“Your health insurance provider can tell you which therapists are in-network and what portion of treatment costs they will cover.”
Ask for Referrals from Friends and Family
Another way to find a physical therapist for direct access is by asking friends and family members for referrals. Chances are, someone you know has seen a physical therapist in the past and can recommend one based on their experience. You can ask for recommendations via phone call, text message, or social media platforms such as Facebook groups and Twitter chats.
If you’re comfortable doing so, share your condition, symptoms, and goals with your loved ones. They may have seen similar issues or had positive experiences with specific therapists that could benefit you.
“Word-of-mouth referrals can provide valuable insight into the quality of care provided by a physical therapist.”
Finding a physical therapist for direct access isn’t an impossible task. By following these steps, patients can identify qualified professionals at reasonable costs, avoid unnecessary referrals, get timely care, and see improvements in their overall health and well-being.
Frequently Asked Questions
Is a referral necessary to see a physical therapist?
It depends on your insurance plan and state laws. Some insurance plans require a referral from a doctor, while others do not. Some states allow patients to see a physical therapist without a referral, while others do not. It is best to check with your insurance provider and state laws to determine if a referral is necessary.
Can I schedule an appointment with a physical therapist without a referral?
It depends on your insurance plan and state laws. Some insurance plans allow patients to schedule appointments with a physical therapist without a referral, while others require a referral from a doctor. Some states allow patients to see a physical therapist without a referral, while others do not. It is best to check with your insurance provider and state laws to determine if a referral is necessary.
What are the requirements for seeing a physical therapist without a referral?
The requirements for seeing a physical therapist without a referral vary by insurance plan and state laws. Some insurance plans allow patients to see a physical therapist without a referral, while others require a referral from a doctor. Some states allow patients to see a physical therapist without a referral, while others do not. It is best to check with your insurance provider and state laws to determine the requirements for seeing a physical therapist without a referral.
Are there any limitations to seeing a physical therapist without a referral?
There may be limitations to seeing a physical therapist without a referral, depending on your insurance plan and state laws. Some insurance plans may limit the number of visits or services that can be received without a referral. Some states may require a diagnosis from a doctor before a physical therapist can provide treatment. It is best to check with your insurance provider and state laws to determine any limitations to seeing a physical therapist without a referral.
How can I find a physical therapist who accepts patients without referrals?
You can find a physical therapist who accepts patients without referrals by searching online or contacting your insurance provider. Many physical therapy clinics will list on their website whether they accept patients without referrals. You can also contact your insurance provider to get a list of physical therapists who accept patients without referrals. It is important to ensure that the physical therapist is licensed and has experience treating your specific condition.
Will my insurance cover physical therapy sessions without a referral?
It depends on your insurance plan. Some insurance plans cover physical therapy sessions without a referral, while others require a referral from a doctor. It is best to check with your insurance provider to determine if physical therapy sessions without a referral are covered. If they are not covered, you may be responsible for the full cost of the sessions.

domain: health


Interest in big data in healthcare is expanding rapidly with the explosion in genomic data and adoption of electronic health records (EHR) resulting from the Affordable Care Act.
This data holds the promise of improved insights into patient outcomes, treatment effectiveness, patient satisfaction and population risk, which is why it is receiving so much attention.
Considerable focus is on how to integrate structured data within your organization, for example, to gain insights from lab data and disease coding, but this is just the first step.
A large proportion of healthcare data is still in an unstructured format represented as documents, reports and images that hold significant levels of detailed data on patients that is not captured, or is poorly captured in structured data. This unstructured text from pathology, radiology and patient narratives captures the entire patient journey and is critical to understanding patient populations, assessing clinical risk and providing a better understanding of disease.
However, the format of the data poses significant challenges to its application and often results in laborious manual extraction to turn it into structured disease codes or specific data sets such as cancer registries. These manual processes are not scalable for the level of discrete data required for analytics and outcomes analysis, but how can this be addressed?
Natural Language Processing, or NLP, enables unstructured text to be translated into discrete data fields by identifying the key concepts and their relationships in healthcare documentation. It enables concepts such as TNM cancer stage, patient ambulatory status and social support network, and ejection fraction to be identified in text and provided as structured fields.
The use of NLP in clinical IT has so far been oriented towards disease coding and clinical document improvement, but these need to be extended into new areas to provide the fuel for big data analytics and population health. We no longer need to limit our analytics to data that is already structured, but can use NLP to provide the data we need, making it possible to test new hypotheses much faster.
To be effective in analysing clinical and other patient related data, simply seeing e.g. a disease name is not enough. NLP establishes the context, whether the disease was ruled out, or whether the mention is in the context of a family history of the disease rather than a diagnosis for this patient. Semantic normalization is also key when analyzing unstructured text.
Knowing Crestor is the brand name of rosuvastatin calcium, which is an HMG CoA Reductase Inhibitor or Statin is vital. Such normalization ensures there is sufficient consistent data for analytics to be applied, avoiding sparsity of data. New sources of unstructured data are also becoming available from patient reported outcomes and social media. This information can also be monitored to see if it can help predict risk or outcomes. Therefore, NLP in the big data age needs above all to be flexible to handle the variety of sources that now make up the patient experience. Effective use of big data will be dramatically improved by making the best use of unstructured data as part of a wider strategy.
NLP plays a key role in turning unstructured text into usable insights and will need to be better incorporated into big data architectures in the future to deliver on its potential.
Find out more about the significance of unstructured data within big data analytics in healthcare.


Mepis is # 5 in Distrowatch. Great reviews
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December 19, 2020
Mexican politicians saw NAFTA as an opportunity to accelerate and block these hard-hit reforms in the Mexican economy. In addition to trade liberalization, Mexican leaders have reduced public debt, introduced a balanced budget rule, stabilized inflation and built up the country`s foreign exchange reserves. Although Mexico was hit hard by the 2008 financial crisis because of its dependence on exports to the U.S. market – the following year, Mexican exports to the United States fell by 17% and its economy fell by more than 6% – its economy rebounded fairly quickly and returned to growth in 2010. Authorization decisions should take into account the overall objectives of NAFTA, which are designed to facilitate trade between Canada, the United States and Mexico. The North American Free Trade Agreement (NAFTA), signed by Prime Minister Brian Mulroney, Mexican President Carlos Salinas and U.S. President George H.W. Bush, came into force on January 1, 1994. NAFTA has created economic growth and a rising standard of living for the people of the three member countries.
By strengthening trade and investment rules and procedures across the continent, Nafta has proven to be a solid foundation for building Canada`s prosperity. NAFTA replaced Canada-U.S. Free Trade Agreement (CUFTA). Negotiations on CUFTA began in 1986 and the agreement entered into force on 1 January 1989. The two nations agreed on a landmark agreement that put Canada and the United States at the forefront of trade liberalization. For more information, visit the Canada-U.S. Free Trade Agreement information page. It was also the first Canadian election to use a lot of negative publicity; Anti-free trade advertising showed that negotiators were “moving away” from the free trade agreement, which turned out to be the Canada-U.S. border at the end of advertising.
Although some opinion polls showed that there were slightly more Canadians against the deal than for him, the Mulroney Progressive Conservatives took advantage of being the only party in favour of the deal, while the Liberals and the NDP divided the vote on free trade. In addition, future Quebec premiers Jacques Parizeau and Bernard Landry supported the agreement, which was seen as a factor in supporting the PC party in Quebec.  Mulroney won a government majority and the agreement was introduced into law, even though a majority of voters had voted for parties opposed to free trade.   The agreement between the United States of America, the United States of Mexico and Canada is a free trade agreement between Canada, Mexico and the United States in lieu of the North American Free Trade Agreement (NAFTA).    The agreement has been referred to as NAFTA 2.0 or “New ALEFTA, since many nafta provisions have been introduced and its amendments have been found to be largely incremental.
© 2021 Zoe Tennesen . Creative Director | Theme by Eleven Themes


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The feature image is a juvenile Brown Pelican learning to fish and practicing taking off & landing. Watching this bird was a lot of fun. The momentum got better with each time this bird took off & landed. In the beginning, this pelican was quite clumsy, but he always left a trail of droplets from the St. Johns River in his wake.
This post is in response to TERRI WEBSTER SCHRANDT Sunday Stills challenge. The theme this week is Water Droplets.
and for Cee’s Flower of the Day – keep scrolling!
Our front yard fountain that my hubby made from an old turkey roasting pan and pieces of slate & granite. I was able to capture a droplet from the flow of the water.
Two different hibiscus in our gardens a few years ago.
The last 5 photos were taken today. It was still raining when I went out there to get some shots. How lucky am I that it rained today when we haven’t seen any precipitation in over a week? Woohoo!

domain: hobby


Annick D'Auteuil is an associate research officer at the NRC, and is the NRC's sports aerodynamics expert.
"My motivation to pursue a career in engineering is the challenge to resolve problems that will help our society to live better together."
Annick's passion for this area dates back to her days as an engineering student at Laval University. As an undergrad, she gravitated towards classes in aerodynamics because the applied examples used in the classroom often related to sport, one of her main interests. Doctoral studies pursued a few years later gave her the opportunity to combine both passions – science and sport – and launched her career.
From lugers to Paralympian skiers, Annick has worked with Canadian athletes for close to 15 years, using the NRC's wind tunnels to help them gain a competitive edge. The results of her work were on display during the recent 2018 Winter Olympics in PyeongChang, South Korea.
When not helping Olympic athletes reach the podium, Annick is busy analyzing the aerodynamic properties of "anything that doesn't fly." Currently, Annick and her colleagues are investigating how freezing rain can affect the aerodynamic behaviour of cables used for cable-stayed bridges.
You can find out more about Annick in this video feature: Meet Annick D'Auteuil – the NRC's sports aerodynamics expert.


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NVIDIA has reported their Q3 2022 earnings today and it was good news to say the least. The company’s quarterly report was stellar with products like NVIDIA AI and RTX GPUs out the door, for which demand is astronomically high in both areas. If NVIDIA is having issues with semiconductor resources, it also didn’t show up here. The company is booming and it lead to the report that it had achieved record revenue and a solid earnings-per-share (EPS) this last quarter, beating consensus estimates on both.
The NVIDIA (NVDA) company released its Q3 2022 earnings report on its investor relations website on November 17, 2021. According to the report, NVIDIA pulled in $7.1 billion USD in Non-GAAP revenue - reportedly a record quarter for the company. This was also a win versus the consensus estimate of $6.83 billion, and a pretty hefty win at that. Its non-GAAP EPS was also a winning stat. The company achieved a non-GAAP EPS of $1.17 per share versus consensus estimate of $1.1. Both numbers made for a pretty stellar Q3 report for NVIDIA.
Company CEO and founder Jensen Huang attributed NVIDIA’s massively strong quarter towards its currently running and high-demand products, including NVIDIA’s latest RTX graphics products and its AI services, as described in the accompanying press release.
NVIDIA’s powerful performance is unique in Q3 in a world affected by issues of supply in terms of the semiconductor famine and shipping ports being congested, as noted by Tesla. With the absolute difficulty of obtaining an NVIDIA RTX GPU right now, it at least looks like demand is in NVIDIA’s favor for the foreseeable future. Stay tuned to Shacknews as we cover further Q3 earnings reporting from throughout the gaming and tech industry.

domain: news


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Vici for Sylvestre Bonnet: new light on cancer therapy
Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.
Chemo with light
‘Ordinary chemotherapy makes too little distinction between good and bad cells', Bonnet explains. 'It kills not only cancer but also healthy cells.' Together with his group he, therefore, works on molecules that do not pose a danger to the body, because they only become active under the influence of visible light. During treatment, a patient takes these medicines and lets them spread throughout the body. Then, by illuminating just the tumour, the drug only becomes active there and only the bad cells are attacked. 'Our molecules are naturally toxic but are protected by a light-sensitive group. If you irradiate them, this group disappears and the molecule can react with the target: the cancer cells.
Light therapy against cancer already exists and is called photodynamic therapy. The problem with the current therapy, however, is that it works only with oxygen. 'These molecules use the energy of light to activate the oxygen in the irradiated cancer tissue,' Bonnet says. As a result, it becomes more reactive and then destroys the cancer cells.' However, some tumours are poorly perfused and therefore low in oxygen. In these so-called hypoxic tumours, regular phototherapy does not work. Other therapies, such as radiation and regular chemotherapy, are also less effective against these type of tumours. That is why Bonnet focuses on this group. 'We make molecules that under the influence of light split into two toxic parts, without the influence of oxygen. These molecules can therefore also attack tumours with little oxygen. For this purpose, Bonnet uses metal complexes with the metal ruthenium
With his Vici grant Bonnet wants to solve a second problem. 'The current light therapy focuses on DNA. An active molecule binds to a DNA molecule and destroys it, causing the entire cell to break down. The problem, however, is that DNA is not cancer-specific, because it is in every cell. Furthermore, hypoxic cancer cells are often resistant to DNA attacking molecules. That is why we want to make molecules that are more selective, that work on a protein that is specific to cancer'. But that is quite difficult, according to Bonnet. Whereas it was still relatively easy to bind metal to DNA, binding to a protein is a lot more complicated. 'If you want to block a protein with a molecule, that molecule must fit very specifically in the protein. That is quite tricky, because you have to deal with many criteria: the charge of the molecule, the hydrophobicity, the shape... it all determines whether it fits or not.'
Veni, vidi, vici
After a Veni grant in 2008 and a Vidi grant in 2012, the triptych for Bonnet is now complete. He started out as a photochemist, but during his career biology more and more became part of his research. 'During my Vidi research, I didn't know anything about the whole oxygen issue. I now have a team with biologists around me and keep learning new things. Together we are now really working on the clinical relevance of these molecules. It's great to develop things oncologists can use to treat patients!'
The Vici grant of Sylvestre Bonnet is not the only one for the Leiden Institute for Chemical Research (LIC). Jeroen Codée also received a Vici: his goal is to unravel the mechanism behind the synthesis of sugars. This year 72 scientists submitted a proposal for a Vici grant within the framework of Exact Sciences and Natural Sciences, the NWO honoured 12. A sixth of this was awarded to the LIC. Vici is one of the largest personal scientific grants in the Netherlands and is intended for highly experienced researchers who have demonstrated that they can successfully develop their own innovative research line and who can act as a coach for young researchers. The grant is awarded by the NWO: The Netherlands Organisation for Scientific Research.

domain: medical


With Kansas coming to play a four-game series at Miller Park, BYU’s baseball team knows “there’s no place like home.”
The Cougars (9-11) have a 2-1 mark at Larry H. Miller Field and play Kansas (13-6) starting Wednesday and Thursday at 6 p.m. Game time for Friday has been moved from 6 p.m. to 3 p.m. because of weather. Saturday’s game remains at 1 p.m.
“We are looking forward to finally being back on our own field,” BYU coach Mike Littlewood said. “Kansas is having a great year, so we know they will be a challenge.”
Wednesday’s starting pitcher for BYU is Desmond Poulson (2-0, 2.29), followed by Adam Miller (1-4, 4.45 on Thursday evening. The Cougar starter in Friday’s modified starting time is Jeff Barker (2-2, 4.33). The BYU starter for Saturday’s game is yet to be named.
BYU is the nation’s No. 1 team in turning double plays, but the Cougars have struggled in other areas as they got off to an 0-3 start on the road in the West Coast Conference. BYU had a 2-1 record in games earlier this year at Miller Park against No. 21 UC Irvine.
Kansas has a 2-1 record in the Big 12 Conference.
BYUtv and KOVO Radio 960 AM are scheduled to broadcast the last three tilts of the four-game series between BYU and Kansas.
Ralph R. Zobell has worked for BYU Athletic Media Relations in various capacities for over 30 years. You can view his bio at http://byucougars.com/staff/athletics/ralph-zobell or contact him at email@example.com.
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text:
Whenever I hear that Greek Fire has a show, I make it a point to shoot it whenever possible. These guys just put on a show that’s incredibly thrilling for their fans and fantastic for photographers. This show was all the more so a must-see because it marked the long-awaited return of drummer Johnny Venus. [...]
Brookroyal always puts on a great show, and their ever-intense performance at the Point’s Ho Ho show with Greek Fire was no exception. Lots of searing hot white light from the back of the stage made this a challenge in terms of photography, but one that had some rewarding results as well.
Sometimes, you’re on assignment for a small gig without a pit. And sometimes, during said gig, they light the entire show with yellow-orange front-lighting. What do you do?
It can be hard to gauge how a band’s touring production can translate from one venue to the next. Having seen a handful of images from Awolnation’s 2012 tour, I knew that the band was coming with a big lightup logo and a few LED arrays at the back of the stage, but beyond that, [...]
Quick preview from last night’s epic set with Greek Fire at Pop’s for 105.7 The Point’s HOHO show. If you haven’t heard of Greek Fire before – trust me, you’ll be seeing some big things from these guys.
The Dillinger Escape Plan are one of my favorite bands to photograph. Show after show, they prove themselves on the stage as one of the best live acts on the planet. And not through an elaborate stage production, but seemingly through a force of will to pretty much annihilate themselves on stage every single night. [...]
Opening for Motörhead, Clutch brought their blues-tinged hard rock down like a sledgehammer on an extremely sold-out crowd. Somewhat surprisingly, Clutch also had the most photogenic lighting of the night with just the right amount of haze and big, bold splashes of backlighting.
Suicide Silence was the last band up before Megadeth on the Endgame tour and they brought a crushing set of deathcore under equally brutal red lights.
June 13, 2009 – Led by the ever vehement Tim McIlrath, Rise Against closed down the night with a fiery set after stellar sets by Rancid and the Riverboat Gamblers.
April 15, 2009 – Headlining the AP Tour 2009, Atlanat’s crunkcore kings Family Force 5 brought a raucous dose of crushing riffs, danceable beats, and charged chorus lines that had the pit heaving.
Alternative Press, #249, January 2009, page 38 – Alternative Press is running a half-page shot of Cobra Starship that I made back in October in their current issue.
Just one shot for today, from Tyga’s performance in support of Metro Station. I set up one SB-600 speedlight camera left on a speaker stack and triggered it with the Nikon SB-900.
August 12, 2008 – Filter frontman Richard Patrick brought the sonic napalm, his signature high range, and a pair of primed lungs to the stage in the band’s high-energy performance at Pop’s.
From the opening bars of “Fall Back Down,” the pit is a seething, frothing mass of bodies, metal studs, and spiked hair. By the second song, crowd surfers are coming toward the stage faster as security can catch them, crashing in waves across the barricade at the front of the pit.

domain: artistic


text:
We don't know exactly how things will go down at Wednesday's closed-door, secret-ballot House Republican Conference meeting. But we expect rank-and-file Republicans to vote late morning or midday to boot GOP Conference Chairwoman Liz Cheney, R-Wyo., from her leadership post.
The meeting begins at 9 a.m. ET.
But there are two wild cards.
Fox News is told the House Republican Conference probably won't move right away to install Rep. Elise Stefanik, R-N.Y., as Cheney's successor. Expect a candidate's forum for those interested in the job Thursday and another vote on the leadership slot Friday.
"I think it will be a few days," said one senior House Republican leadership source.
But Fox News is told Stefanik shouldn't have a problem eventually becoming the conference chairwoman.
Rep. Chip Roy, R-Texas, and other Freedom Caucus members are making noise about whether Stefanik is in fact conservative enough. It's possible the GOP could leave the seat vacant through the end of the week – or even longer – if enough Republicans aren’t ready to vote in Stefanik as Cheney’s replacement. Moreover, this could all go sideways because of the first meeting President Biden is slated to have with the bicameral, bipartisan congressional leaders. That meeting is slated for late morning. The GOP Conference meeting about Cheney and Stefanik could run headlong into the White House session. That causes another headache for House Minority Leader Kevin McCarthy, R-Calif.
But Fox is told the vote to remove Cheney "should be straightforward."
Here is the "by the book" process:
Members can present a petition or resolution to remove Cheney. It must be signed by 50 members. By rule, two-thirds of the conference needs to call for an immediate vote on the resolution. Otherwise, the conference might move the issue to the Steering Committee, which decides committee assignments, et al. The Steering Committee would have to then decide whether to move the issue to remove Cheney to a conference vote. The vote would likely be conducted via secret ballot.
It takes a simple majority to remove Cheney.
That said, House Republican Conference rules give McCarthy great latitude. The rules allow him to make a motion on his own. And McCarthy is clearly willing to ditch Cheney.
In February, only one member signed the petition to get rid of Cheney: Rep. Dan Bishop, R-N.C. Cheney said she wanted a vote. It was McCarthy who moved the vote of no confidence right away. Cheney prevailed in that vote, 145-61.
Fox has spoken with multiple House Republicans, both rank and file, and in leadership, who believe that McCarthy is moving too fast. Fox is told that McCarthy would like to wrap this up quickly. But he is getting an earful from some Republicans who would prefer to take their time in selecting a successor to Cheney – even if McCarthy handpicked Stefanik and cleared the field. That’s to say nothing of the endorsement of Stefanik by former President Trump.
Remember, McCarthy is trying to thread the needle here – especially if he wants to be speaker in 2023 if Republicans win the House. Some Republicans Fox News spoke with indicate that McCarthy erred in moving too decisively with Stefanik.
Also, here is the worst-kept secret in the Capitol: Yes. Lots of Republicans don’t appreciate what Cheney has said about Trump, the election and the Jan. 6 riot. But frankly, here is one of the key reasons Republicans are ready to abandon Cheney now:
"No one actually likes her," said one Republican. "No one is there to defend her."

domain: politics


text:
Tumor relapse and acquired chemotherapy resistance are two major factors leading to the high mortality of epithelial ovarian cancer (EOC) patients. It has become increasingly evident that ovarian cancers contain subpopulations of cancer stem cells (CSCs) with enhanced tumorigenicity and chemoresistance. These CSCs are believed to be responsible for treatment failure and tumor relapse. However, it is still unclear how CSCs survive DNA-damaging agent treatment, and how the tumor regenerated by the surviving CSCs develops chemoresistance. Error-prone translesion DNA synthesis (TLS), a DNA damage tolerance mechanism that bypasses DNA damage during replication, has been suggested to mediate acquired chemoresistance. Our recent studies have revealed that ovarian CSCs show elevated expression of TLS polymerase ? (Pol?); we also demonstrated that Pol? is critical to the survival of ovarian CSCs following cisplatin treatment. Based on this scientific premise, we generate a hypothesis that enhanced Pol?-mediated TLS in CSCs contributes to tumor relapse and the development of acquired cisplatin-resistance after initial cisplatin treatment, by facilitating CSC survival and increasing CSC mutagenesis. The main objective of this proposal is to determine a novel mechanism that contributes to EOC relapse and chemotherapeutic resistance following initial cisplatin treatment.
Two specific aims are proposed to test this hypothesis and achieve our goal.
In specific aim 1, we will determine the contribution of Pol?-mediated TLS to EOC relapse after cisplatin treatment.
In specific aim 2, we will delineate the contribution of Pol?-mediated TLS to the development of acquired cisplatin resistance in the EOC and cisplatin-induced mutations in ovarian CSCs. The rationale under this proposal is that understanding the mechanism underlying tumor relapse and chemotherapy resistance would facilitate the development of new therapy strategies to improve the outcome of patients with EOC. It is our expectation that at the conclusion of this project, we will have provided solid evidence showing that enhanced expression of Pol? in ovarian CSCs contributes to the tumor regrowth, mutagenesis in CSCs, and the development of cisplatin resistance after initial cisplatin treatment. Downregulation of Pol? would significantly inhibit tumor relapse and prevent the development of cisplatin resistance, and thus, can be exploited for a new therapy strategy for EOCs.
Ovarian cancer is the fifth leading cause of cancer-related deaths in women in the United States. Most of the tumors are initially responsive to platinum-based chemotherapy, and the majority of signs and symptoms of cancer are gone. However, cancer can come back and become resistant to the drug. Indeed, 90% of the deaths from ovarian cancer are due to tumor return and drug resistance. Poor understanding of this drug resistance is a critical cancer research challenge. In this project, we plan to determine the role of cancer stem cells and their genomic instability in the tumor recurrence and the subsequent development of cisplatin resistance. Ultimately, we hope to identify new ways to increase the longevity of cancer patients.
|Rhodes, Curran A; Dougherty, Patrick G; Cooper, Jahan K et al. (2018) Cell-Permeable Bicyclic Peptidyl Inhibitors against NEMO-I?B Kinase Interaction Directly from a Combinatorial Library. J Am Chem Soc 140:12102-12110|
|Wang, Jin-Ting; Xie, Wen-Quan; Liu, Fa-Quan et al. (2018) NADH protect against radiation enteritis by enhancing autophagy and inhibiting inflammation through PI3K/AKT pathway. Am J Transl Res 10:1713-1721|
|Zeng, Rong; Liu, Yi; Jiang, Zhao-Jing et al. (2018) EPB41L3 is a potential tumor suppressor gene and prognostic indicator in esophageal squamous cell carcinoma. Int J Oncol :|
|Cui, Tiantian; Srivastava, Amit Kumar; Han, Chunhua et al. (2018) DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1. Cell Death Dis 9:561|
|Chen, Zhong; Wu, Dayong; Thomas-Ahner, Jennifer M et al. (2018) Diverse AR-V7 cistromes in castration-resistant prostate cancer are governed by HoxB13. Proc Natl Acad Sci U S A 115:6810-6815|
|Zhang, Tianyu; Xu, Jielin; Deng, Siyuan et al. (2018) Core signaling pathways in ovarian cancer stem cell revealed by integrative analysis of multi-marker genomics data. PLoS One 13:e0196351|
|Srivastava, Amit Kumar; Rizvi, Asim; Cui, Tiantian et al. (2018) Depleting ovarian cancer stem cells with calcitriol. Oncotarget 9:14481-14491|


text:
Looking at the Coronavirus pandemic continuously escalating, we all wonder exactly what measures should we take to protect ourselves. Social distancing, washing hands, disinfecting; is that all enough? The virus is increasing like a wildfire. Nevertheless, people are trying their best to think up the techniques for preventing the spread of COVID-19.
HEPA AIR PURIFIERS FOR COVID-19
Just like masks and gloves, people are now turning towards purifying the air to reduce the risk of COVID-19. When an isolation room air cleaner can remove dust and smoke, it can certainly remove the virus. Isn’t it? So, the question here crops up: can HEPA air purifiers keep us safe from the coronavirus? The answer to this question is complicated, looking at so many things connected with the epidemic.
LET’S FIRST-OF-ALL LEARN HOW IT SPREADS
It is not confirmed that COVID-19 is an airborne virus. Nevertheless, it is confirmed that it spreads through contact factors and respiratory droplets. As an infected person often goes around their day with no symptoms, their hands may carry viral particles that can stay on any object they touch. If a person holds these objects and then touches areas like their eyes, nose, lips, etc. the virus can enter the body and start using its cells and replicate.
COVID-19 also spreads through droplets. Sneezing or coughing discharges droplets of fluid into the atmosphere that contain mucus, water, and viral particles. People breathe in these droplets and get infected.
You may here consider that COVID-19 is an airborne virus. But no, it is not. There is a vital difference between the droplet and airborne transmission. It is essential to understand the difference before we talk about the HEPA air cleaner.
DIFFERENCE BETWEEN DROPLET AND AIRBORNE TRANSMISSION
The major difference between both is the suspension time, size of the particle, and composition.
Droplets are far bigger than airborne viruses. When viruses float around 0.1 um in diameter, respiratory droplets tend to be more than 5 um or even more upto 10 um in diameter. Furthermore, the droplets are full of the virus and mucus, saliva, water, including various other bodily fluids. That makes them far bigger and heavier than airborne viral particles. For being heavy, droplets will relatively quickly fall from the air on the surfaces where we touch and come into contact with the virus. Above all, we can sanitize the viral particles with the help of good virus disinfectant agents available in the market.
When droplet viruses like COVID-19 end their journey once the droplets fall, airborne viruses stay in the atmosphere, perhaps riding on the dust particles present in the air. Since airborne viruses are light weighted, they remain in the air for hours. However, they are particularly contagious because of this. We all have heard about measles and tuberculosis. Both are airborne viruses.
We have purposely treated both paths of virus transmission. Since droplet transmission is consentaneously confirmed, our major focus will be on respiratory droplets. So, can an air purification system aids to remove respiratory droplets?
DOES HEPA AIR PURIFIERS ELIMINATE RESPIRATORY DROPLETS?
A HEPA air cleaner can deal with particle pollution. The machine blows air through a filter and removes any contaminants present in the atmosphere. If there are virus droplets in the atmosphere surrounding you, the filter can strain them out.
Nevertheless, the air purifiers also come up with a drawback. Even though the cleaners clean out the respiratory droplets, the process will not happen instantaneously. The air purifier will take some time to cycle through the entire room. Meanwhile, the droplets will settle down on the flat surfaces in the area.
In the odds, your HEPA air cleaner may not eradicate the droplets at the speed that you need to steer clear of infection at least, not as quickly as the normal settling speed of the droplets. However, if COVID-19 is an airborne virus, the filter would have the ability to eradicate the larger chunk of viruses. Nevertheless, you would still be insecure. Regardless of what type of virus COVID-19 is, you cannot just rely on an air cleaner to protect yourself.
Also read: COVID-19 and Isolation Room Air Cleaners
Nevertheless, the usage of HEPA air purifiers is still advised during the COVID pandemic. Though they will not eradicate the virus droplets, the air purifiers are still handy bits of technology for getting rid of particles and fine dust and improving the indoor air quality of your space and your health on the whole. HEPA air cleaner installation will not harm but will certainly keep your indoor air quality in better shape.
To fight the spread of COVID-19, staying home, using a disinfectant, and washing hands regularly are two of the right and more effective ways to stay safe. Indeed, HEPA air purifiers are not the substitute for disinfectant or social distancing. In some places, there are indications that the epidemic is easing, but we should not stop. Till the new coronavirus is not under control, keep social distancing, and make sure to pay your attention to only the trusted resources for the most updated and precise information regarding the outbreak.

domain: biology


text:
The Ghana Grid Company is blaming “power swings” for Tuesday’s widespread power outage in the country.
The company in a statement, said the problem arose from the Cote d’Ivoire interconnection with Ghana leaving several parts of the country in darkness.
Ghana Grid Company Limited (GRIDCo) wishes to inform the public that at 2:37 PM, there was a major system disturbance following power swings from the Cote d’Ivoire interconnection with Ghana, leading to outages in parts of the country.”
Some parts of the country begun getting power after 6pm on Tuesday but GRIDCo said most parts of the country that were affected have had their power restored.
It added that, power is being restored to areas that are still without power.
“Power supply has been restored to most parts of the country and efforts are currently underway to restore the remaining affected areas.”
“GRIDCo apologizes for any inconvenience caused, and remains committed to its mandate of delivering reliable power supply,” the company added in the statement.


(Single reed with cylindrical bore with fingerholes)
|Inventor(s)||Brian L. Wittman|
A xaphoon (pronounced "za-foon"), is a chromatic "Bamboo Sax" or single-reed instrument/woodwind instrument. It has a straight cylindrical tube with cylindrical bore and a very slightly flared bell. The xaphoon plays a fully chromatic scale somewhat beyond two octaves, and overblows at the 12th, like a clarinet.
The first xaphoon, made out of bamboo in 1972, was a spontaneous effort by Brian Wittman (a Hawaiian saxophonist and multi-instrumentalist) to create an instrument for a young child who liked the sound of the saxophone. Wittman was impressed by the sound of the simple instrument and by demand started to manufacture and sell it.
The design of the xaphoon is patented.
The range of the xaphoon happens to be comparable to the chalumeau, a European keyless single-reed instrument that was the ancestor of the clarinet; therefore the Xaphoon can be used to play written chalumeau music, as well as music in any other style associated with the saxophone or clarinet. In addition to the chalumeau, similar instruments bearing other names exist in other regions. These include the Heping Flute 和平笛 and the Ebi (from Yunnan), both of which use the design of putting a single reed on a Dongxiao, a vertical flute. Other variations include various bamboo/pocket/mini saxes that include an actual saxophone mouthpiece (sometimes connected at a curve.)
Due to its abbreviated length and large finger-hole size, the pitch of individual notes can be raised and lowered easily, making the xaphoon equally well-suited to play Turkish, Middle Eastern, and other musical scales outside the European tradition. The xaphoon has been made commercially available by Brian Wittman since 1975; Wittman still makes approximately 1500 bamboo instruments per year by hand at his home on the island of Maui, Hawaii, using local bamboo selected from the forests of the eastern end of the island.
Use and availability
The xaphoon is available from Maui Xaphoon (Brian Wittman's company) in the keys of C, B♭, D, and G (as well as any other key via special order). It uses a standard tenor saxophone reed. Its body is 12.5 inches / 32 cm long (for the instrument pitched in C) and has nine holes (eight holes in front, and one hole in back for the left thumb) that resemble those of a recorder. The xaphoon's fingerings, however, are significantly different from those of either a saxophone or recorder.
Plastic issue "Pocket Sax"
In the spring of 2000, a molded ABS version of the xaphoon following Wittman's patented design was introduced. These instruments are made under license by Indiana Plastics of Elkhart, Indiana, and are marketed under the trade name Xaphoon Pocket Sax. Currently, it is available in the key of C, with its lowest tone being C below middle C. The instrument is sturdy, and the reed can be protected by a cap when not played.
In the spring of 2012, Wittman began a collaboration with Francesc Sans Sastre, a long-established luthier in Sant Jaume de Lleirca, Girona, Spain to produce hand-made wooden xaphoons in strict accordance with the original xaphoon design. A limited number of these collector instruments will be made available in coming years under the name "Xaphoon de Catalunya".
While the popularity of the xaphoon has led to frequent use of the word "xaphoon" to denote any type of small single-reed keyless woodwind instrument, the term remains a registered trade name. Only those instruments produced by Brian Wittman (Maui Xaphoon), Indiana Plastics (Xaphoon Pocket Sax), and Sans Luthier (Xaphoon de Catalunya) are allowed to be called xaphoons.
Trademark and patent
"Xaphoon" is a registered trademark (Trade Name – Hawaii File Number 116995D1,Trade Mark – Hawaii File Number 50914ZZ), owned by Brian Wittman under the Hawaii-based sole-proprietorship "Maui Xaphoon". The instrument is patented under US Patent D262035.
- Video of all the xaphoon sounds (flute, sax, bruitism)
- xaphoon sound panorama
- xaphoon sound
- Xaphoon Sound Example: Bei Mir Bist Du Schon
- Video – Nobody Knows The Trouble I've Seen


text:
Monkfish wrapped in Kadaïf noodles, with cauliflower and hazelnut purée and a coconut milk broth
A recipe that takes you on a journey and delights you with its oriental flavours. This recipe is brought to you by Chef Basile Arnaud, head chef at Le Mas Candille’s restaurants: Le Bistrot du Mas and Le Candille *.
A note from Chef Basile Arnaud
I love this dish, a total oriental journey with the kadaïf noodles and various spices. You will also find some fantastic Asian notes with ginger and coconut, not to mention the Indian touch by the curry. It is a beautiful way to escape and feast your taste buds with flavours that I particularly love… I enjoy putting them front and centre from time to time in my cuisine.
Recipe for 2 people
- 300g monkfish
- 1 egg yolk
- 40g madras curry powder
- 40g ras el hanout
- 10g honey
- 10g olive oil
- 400g kadaïf or Turkish noodles
- 4 pieces of cauliflower
- 20g hazelnuts
- 2l coconut milk
- 2 lemongrass sticks
- 2 pieces of ginger
- 2 pieces of purple cauliflower
- 2 pieces of romanesco
- 2 pieces of yellow cauliflower
- 2 packets of shiso
- 2 packets of edible flowers
- fleur de sel and pepper
- 2 pinches of Espelette pepper
- a deep fryer
- a brush
- a good knife
- a skimmer
- a pipette (optional)
Time to make
Prepare the monkfish, cut it into 150g servings. With a brush, coat the portions with the spices, honey and olive oil mixture and season with a pinch of fleur de sel.
Coat the monkfish with the egg yolk, gently surround the monkfish with kadaïf noodles (uncooked). Then wrap the portions with cling film, set in the fridge for at least 30 minutes.
Meanwhile, boil the cauliflower for 20 minutes to make a purée. When mixing, add roasted hazelnuts and set aside.
Cut small multicoloured cauliflower heads and cook in boiling water for 6 minutes.
Make a coconut milk broth with lemongrass, ginger, raz el hanout and a pinch of chilli. Mix everything together and cook for 30 minutes. Once the broth is well infused, put everything in a colander to recover only the liquid from the broth.
Remove the monkfish from the fridge and gently remove the film – make sure the kadaif noodles stay on the fish.
Fry your fish at 180 degrees for 2 to 3 minutes in a deep fryer. If you don’t have one, fill a deep saucepan with special frying oil and cook over low heat. Season with fleur de sel, pepper and a pinch of chilli and it’s ready!
Take a plain plate. Cut the cooked monkfish in half and place it in the middle of the plate. Put the cauliflower purée in a pipette and make dots of cauliflower puree around the plate. Place the cooked coloured cauliflowers around the plate. Finally, decorate with small flowers and shiso. Serve the broth separately.
Read Chef Basile’s second recipe here!
Read Chef Basile’s first recipe here!

domain: food


text:
WILSON v. DAVIS.†
Defendant appeals from a judgment entered in favor of plaintiff for the sum of $10,000 upon the return of a jury's verdict. This litigation originated in the negotiations of the parties relative to their efforts to have probated two wills of the late Emma H. Wilson, who died on October 5, 1934. Plaintiff filed for probate a will dated May 17, 1933, in which he was named a beneficiary and the executor. Defendant filed for probate a will dated October 24, 1933, in which she was made the principal beneficiary and was named executrix. Plaintiff was not mentioned in this will. A third will was executed by Emma H. Wilson under date of August 22, 1933. There is a conflict in the testimony regarding the contents of this third will. Plaintiff testified that he was named therein as a beneficiary and defendant testified that she was the sole beneficiary. The will, however, became lost or was destroyed and was not offered for probate.
In his complaint plaintiff sets forth an instrument directed to himself and signed by defendant under date of January 20, 1934, as follows: “Dear Bob, I feel that you and I should settle our affairs between us without Lawyers so I trust you will not say anything to your Lawyers as well as myself. I will give you the equivalent of $10,000 upon the consideration that you will tell the truth about my Dear Sister Will of Aug. 22, 1933, as you know this will left everything to me. Bob you know I worked and put my money into everything Emma bought and we both agreed that it should go to me if any thing happens to her. Lots of love to you and Margatet.” In his complaint plaintiff alleged that defendant had promised to pay to him the sum of $10,000, upon consideration “that plaintiff withdraw his contest to the probate of said holographic will under which said defendant was the principal beneficiary, and his objection to the appointment of defendant as executrix thereunder, and upon the further consideration that plaintiff would withdraw his petition to probate the will of Emma H. Wilson dated May 17, 1933, under which will plaintiff was a beneficiary, and his request to be appointed executor thereunder.” By her answer defendant alleged that there was no valid consideration for the promise to pay the sum of $10,000. She asserts that the sole consideration was an agreement on the part of plaintiff to “tell the truth about the will dated August 22, 1933.”
The defendant contends that the court erred in refusing to give to the jury the following instruction: “The Court instructs the jury that in this case the defendant has alleged that there was no consideration for the claims of plaintiff. If you find from the evidence that the paper sued upon herein, to–wit, the one bearing the date of January 20, 1935, was given only in consideration as therein stated, that Robert Wilson tell the truth about the will of the sister of Mrs. Davis bearing date of August 22, 1933, then I charge you that there is no consideration for the reason that everyone is always required or at least expected to tell the truth of and concerning matters and things.” This instruction should have been given. The principle of law set forth therein is not covered by any of the instructions given by the court. The making of a promise to do that which the promisor is legally bound to do does not furnish a valid consideration for the promise of another. Marinovich v. Kilburn, 153 Cal. 638, 96 P. 303; Sullivan v. Sullivan, 99 Cal. 187, 33 P. 862. “This is merely the converse of the rule stated in section 1605 of the Civil Code to the effect that any benefit to the promisor to which he is not legally entitled, or a detriment to the promisee which he is not lawfully bound to suffer, is a good consideration.” 6 Cal.Jur. § 122, p. 179. The evidence is in sharp conflict on the question of the true consideration for the agreement sued upon. Defendant was entitled to have the jury instructed as to the principle of law applicable in case the jury should find the facts in accordance with her contention.
The judgment is reversed. The purported appeal from the order denying a new trial is dismissed.
We concur: CRAIL, P. J.; McCOMB, J.

domain: law


text:
Beat Saber has been updated to version 1.35 on PS4 and PC. Here are the full patch notes that are available for this new update.
This is a small hotfix update for the game that resolves a minor crash issue. It is available to download now for PS4 and PC. If you were experiencing this issue, download the update to fix it.
Beat Saber Update 1.35 Patch Notes
- Fixed crashes when playing with Insta Fail or Battery Energy modifier.

domain: game


"My entire life people have told me my sexuality," the "High School Musical: The Musical: The Series" star, 20, wrote in a lengthy letter on Twitter.
In an unprompted review of "Law & Order: SVU" on Instagram, Mickey Rourke, 68, took a jab at Marvel Studios, hinting he's still mad about "Iron Man 2."
The “Thor” actress was seen touring a bucolic Australian house outside Sydney recently, The Post has exclusively learned.
First listed on Friday, the home is made up of five bedrooms and six bathrooms and was purchased in 2018 for $1.62 million
"She wouldn't just publicly tweet about wanting me to take 'a dirt nap' but would privately DM me and tell me to kill myself."
The "drop-dead gorgeous" bovine is described as having "striking eyes and long, dark eyelashes" — just like her 40-year-old celebrity namesake.
Porsha Williams and Falynn Guobadia appeared as "friends" on "Real Housewives of Atlanta" in Season 13.
The actor raved about Louis Farrakhan, blamed "the pharmaceutical industry" for his nutty public image and offered a lecture on Scientology.
Is Bennifer coming back stronger than a 2000s trend? Here, take a look back at the best fashion moments from their two-year romance — from "Gigli" to the Oscars red...
The “Hills: New Beginnings” star is looking for love again.


Photos: Giants Best Cardinals In Game 6 Of NLCS
Galen Nathanson Posted by Galen on 2012-10-21 21:05:17 tags: photo
SAN FRANCISCO—Ryan Vogelsong and the San Francisco Giants saved their season once more, pushing St. Louis to a winner-take-all Game 7 in the NL championship series.
Turns out the defending champion Cardinals aren’t the only team that’s tough to put away in October.
Vogelsong struck out a career-best nine in another postseason gem, and the Giants held off elimination for a second straight game by beating St. Louis 6-1 on Sunday night.
[insertSlideshowjava xml="http://director.denverpost.com/images.php?album=2020" api="dpmc"]
Photos: Seattle Seahawk Garry Gilliam visits Milton Hershey School
Photos: Joey Logano wins 2015 Daytona 500
PHOTOS: NASCAR at Lincoln, Williams Grove 50-plus years ago
PHOTOS: NBA All-Star Game in New York City - Feb. 15, 2015
Photos: Snedecker wins the AT&T Pro-Am
PHOTOS: Final day of the 2015 FIS Alpine World Ski Championships


text:
The Most Generous Master Ever - Chapter 692
[Chapter 692: Curse of the Demon Seed]
When Jiang Ming saw clearly that the person who came in was not Jiang Linger, but Jiang Yaya, his eyes flashed with disappointment.
He thought that it was his aunt who came back this time, but he didn’t expect that it was Yaya who came back.
The great sadness after the great joy made the atmosphere of the scene very depressing for a while.
Yaya could also feel that they were very disappointed, but there was nothing they could do about it. After all, in their hearts, she was just a little girl who hadn’t grown up yet.
“Yaya, why are you back! I remember that I didn’t send anyone to the Holy Land of Butian to send you news.”
Looking at Yaya who was looking at the closed door with concern, Jiang Ming asked suspiciously.
Yaya looked back at him, her eyes were already red from crying, she probably guessed that the father who loved her the most was in danger at this moment.
“Why didn’t you tell me, why didn’t you tell me, if I didn’t get this news from someone else, are you planning to keep it from me for the rest of your life…”
Yaya lost control of her emotions, and she accused her brother in front of her, His Highness the current Crown Prince of Huo Kingdom.
“Yaya, you misunderstood brother, it’s just that this incident happened too hastily, and brother was afraid of affecting your cultivation on the mountain, so he didn’t plan to tell you so soon, and wanted to tell you after all the turmoil passed.”
Remember https:// in one second.
The second prince Jiang Yue on the side explained for Jiang Ming, but Yaya didn’t buy it at all.
Looking at the people arguing in front of them, Ye Qiu and Bai Junlin looked at each other, relatively speechless.
While waiting silently, Bai Junlin moved his nose, as if he smelled something strange.
Quickly asked: “Brother, do you feel a very evil breath?”
Ye Qiu was taken aback when he heard the words, and quickly calmed down to feel it carefully.
Sure enough, after sinking into it, Ye Qiu quickly caught this breath, and its source was precisely the closed door.
After feeling this breath, Ye Qiu’s expression changed instantly.
“Curse of the demon seed! Good guy…you are so ruthless.”
Ye Qiu understood the real reason why the Fire Emperor was tortured so much that life was worse than death, and that he was still lying in the Tai’an Hall and couldn’t get up.
It turned out that he was cursed by a demon seed, and a demon root was planted in his body, which constantly devoured his essence, causing him to die slowly in painful torment.
Thinking of this, Ye Qiu’s heart shuddered, who the hell is this, with such vicious thoughts, making such a murderous move.
The eyes of the sky opened slowly, and Ye Qiu silently inspected everyone around him, but found nothing unusual.
However, he felt that there were a few faint auras in the hall, presumably they were some strong men in the palace, healing the fire emperor.
While Ye Qiu was still in doubt, the closed door slowly opened.
A white-haired old man came out from inside, with a haggard face, shook his head, and sighed.
Seeing this scene, everyone present panicked. Jiang Ming hurried up and asked, “Mr. Qi, how is my father’s injury? Has it improved?”
Upon hearing this, Mr. Qi looked at everyone with a haggard face, shook his head, and said, “Old man… tried my best.”
“The fire emperor’s injuries are very strange. With the old man’s cultivation, there is nothing he can do about it. You…you should hire another expert.”
Mr. Qi, whose real name is Qi Daolin, is a hermit in the Yaowang Valley in the northern part of the Fire Region. His cultivation level is not high, and he only has the realm of a real fairy, but his medical skills are extremely superb, and he is known as the rejuvenation of the hand.
Over the years, in a radius of hundreds of miles, famous families have respected him very much, and he can be regarded as a highly respected sage.
However, after several days of painstaking treatment, he still had no results, so he had no choice but to give up.
The Huo Huang suffered injuries beyond his expectation, even if Qi Daolin wanted to save him, there was nothing he could do.
When everyone heard Mr. Qi’s words, their mood fell to the bottom in an instant.
“Can’t even Mr. Qi cure the father’s illness?”
At this moment, Jiang Ming lost his mind, his eyes were dim, grief and indignation welled up in his heart, and it was difficult to accept this reality.
“Even Mr. Qi can’t cure Father’s illness, who else in the world can cure him?”
“Could it be that our country of fire is doomed to decline here?”
Everyone was depressed and fell into dead silence for a while.
Now outside the imperial palace, the situation is changing and undercurrents are surging, and inside the imperial palace, there are also earth-shaking changes and huge changes taking place.
If the Fire Emperor dies, there will definitely be a mutiny in the next scene, and the power will be out of balance. If the crown prince can’t control the scene.
Then, those dependent forces under the Fire Nation will take advantage of the chaos and start to seize power.
Looking at the depressed people, Mr. Qi couldn’t bear it. How could he not understand the situation that Huo Nation is going through now.
Shaking his head, Mr. Qi said: “If there is one person in this world who can save your father, then it may be the only one left.”
Hearing this, Yaya woke up like a dream, as if she saw hope.
Mr. Qi’s eyes were empty, and he said: “In this world, the only person who can have such great supernatural powers is the one in Butian Pavilion, old man Meng…”
As soon as these words came out, Yaya’s heart trembled instantly, and everyone present trembled even more, and fell into a daze for a while.
“Old man Meng?”
Yes, they all know about Meng Tianzheng, nine days and ten places, almost no one does not know Meng Tianzheng’s reputation.
However, such a respected senior as Meng Tianzheng has been closed for many years and does not care about the world of mortals.
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How could it be possible to go down the mountain specially for a small fire country.
This is almost unrealistic, the Fire Nation doesn’t have such a big face yet.
Seeing their despondent expressions, Mr. Qi comforted him and said, “You don’t have to worry. I have heard that old man Meng has a beloved disciple who has the ability to save all living beings from difficulties. Maybe… if you can invite With his words, your royal father can still be saved.”
As soon as these words came out, everyone instantly ignited hope again.
“Is it Senior Meng’s beloved disciple? Who is it…”
At this moment, everyone was stunned. Why haven’t they heard that there is another apprentice under Meng Tian’s main gate?
Not only were they dumbfounded, but even Yaya herself was dumbfounded.
She is a disciple of Butian Pavilion, even she has never heard of this matter.
Compared to their bewilderment, Ye Qiu looked astonished, and Bai Junlin showed a proud expression after hearing about it.
“Hey, let me just say, hang out with the big brother, as long as you have a face, it’s easy to use anywhere.”
Bai Junlin chuckled, he had probably guessed who Mr. Qi was talking about.
Who else could it be, isn’t it the one next to him, the Son of God.
Sure enough, seeing that everyone was so confused, Mr. Qi continued: “I have heard that a few years ago, there was a fierce battle in the Chilong Mountain Range.”
“During that great battle, hundreds of Tianjiao from nine heavens and ten places besieged the devil Qi Wuhui, and all of them were buried under the sword of the devil, and their bones were buried in Qingshan.”
“Later, a person passed by. He couldn’t bear the misery in the world. He used the magic method of rejuvenation to save thousands of lonely souls and wild ghosts, and save all living beings.”
[End of this Chapter]
***Commenting is only available on the Novel Description Page.

domain: literature


Date of Award
Doctor of Philosophy (PhD)
Human Centered Computing
Dr. Juan E. Gilber, Committee Chair
Dr. Damon L. Woodard, Committee Co-Chair
Dr. Shaundra B. Daily
Dr. Sekou L. Remy
The use of touchscreen interfaces for in-vehicle information, entertainment, and for the control of comfort settings is proliferating. Moreover, using these interfaces requires the same visual and manual resources needed for safe driving. Guided by much of the prevalent research in the areas of the human visual system, attention, and multimodal redundancy the Hues and Cues design paradigm was developed to make touchscreen automotive user interfaces more suitable to use while driving. This paradigm was applied to a prototype of an automotive user interface and evaluated with respects to driver performance using the dual-task, Lane Change Test (LCT). Each level of the design paradigm was evaluated in light of possible gender differences. The results of the repeated measures experiment suggests that when compared to interfaces without both the Hues and the Cues paradigm applied, the Hues and Cues interface requires less mental effort to operate, is more usable, and is more preferred. However, the results differ in the degradation in driver performance with interfaces that only have visual feedback resulting in better task times and significant gender differences in the driving task with interfaces that only have auditory feedback. Overall, the results reported show that the presentation of multimodal feedback can be useful in design automotive interfaces, but must be flexible enough to account for individual differences.
Ekandem, Joshua Ime Asukwo, "Ambient hues and audible cues: An approach to automotive user interface design using multi-modal feedback" (2017). All Dissertations. 1893.


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Pharmacy Guild Queensland branch president Trent Twomey accepts nomination for national president role
Professor Trent Twomey is the single nominee for the presidency of the Pharmacy Guild of Australia, with nominations for the role now closed.
The official Australian Electoral Commission results are expected to be released on Friday.
“I am deeply honoured and humbled by the prospect of serving as the Guild’s National President,” said Prof Twomey in a statement released on Wednesday.
“While I am very excited to serve in this capacity, it is not something that I do lightly. We all know how challenging pharmacy can be, especially over the last 12 months and into the next few years,” he said.
“As a pharmacist living and working over 1600 kilometres from a State capital city [in Cairns, in Far North Queensland], I understand the tyranny of distance and the importance of our community pharmacy network right across the country.”
Prof Twomey has served as Queensland branch president and senior national vice president of the Guild since 2017, and as a Guild national councillor since 2011.
He has also previously served as president of the Australian College of Pharmacy (now the Australasian College of Pharmacy) and president of NAPSA.
He currently holds the role of Adjunct Professor at James Cook University, his alma mater.
“Over my 10 years on the [Guild] national council, I’ve collegiately dedicated my time and effort to ensure our members are fully supported,” he said.
“I’m most proud of those areas where we have been able to deliver more services to our patients and customers and seen off dangerous and unnecessary regulatory changes like 60-day dispensing.
“This election is not about me; it does represent a generational changing of the guard but, more importantly, a continuation of the support, advocacy for and love of community pharmacy.”
Chris Owen, vice president of the Guild Queensland branch, is set to take over as acting president once Prof Twomey steps up to the national presidency, with elections to be held for the state presidency.
“I look forward to working together with community pharmacies across Australia, advocating on their behalf, and together delivering better health outcomes to our patients,” said Prof Twomey.


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domain: entertainment


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My boss has been listening to books for a while and is slowing dragging me into her fascination with audiobooks. I am on my second audiobook and I am really enjoying listening to it. I have a 30-40 commute each way, which gives me ample time to catch up on the book. It is inherently more exciting than listening to traffic reports on KFWB.
The book currentky being played on my iPod is "The Ivy Chronicles" by Karen Quinn. It is a cute story, not too involved for short drives.
I have also downloaded a few of the Disney's Storyteller's Series for the kids:
The Real Story of Winnie the Pooh
The Emperor's New Groove
Who Framed Roger Rabbit?
Am I alone in my listening to books? Are there others here on MiceChat that share my newfound fondness for audiobooks?


text:
Shocking footage has emerged of what appears to be a Russian ambulance crew beating a patient.
This CCTV footage shows two people not dressed in uniform dragging an unconscious patient down a flight of stairs in the early hours of the morning.
After a couple of minutes of struggling to bundle the male patient into an ambulance, the pair resort to violence beating the man.
They finally manage to get him in the vehicle, when as the doors close he can be seen on the floor.
According to local media reports, health bosses have demanded an investigation into the incident which happened on February 27.
The man is believed to have suffered brain injuries before paramedics were called, reports say.
He was transferred from intensive care to a ward but cannot remember much about how he suffered his injuries, relatives said.
Last year a paramedic was banned from working in the profession after abandoning a patient in his ambulance because his shift had ended.


Minsk Arms Exhibition showcases modernized Belarusian armored vehicle
At the 11th International Exhibition of Arms and Military Equipment MILEX-2023, which ended last week in the Belarusian capital of Minsk, another model of the Volat V2 armored car, also known as MZKT 690003, was presented.
To protect the new model, a reinforcement process was carried out, for which an additional armored element was attached to its body, which increased its resistance to bullet wounds from various small arms.
The mass of the armored vehicle after modernization increased by 2400 kg and reached 24500 kg. At this point, the armored vehicle retained the ability to overcome water barriers. However, the fuel range of his new model has decreased by 300 km and reached 900 km.
Its armament can vary, as it can be equipped with two 7.52 mm or 12.7 mm machine guns, or a 30 mm automatic grenade launcher (AGS).
The car moves on paved roads at a speed of 110 km/h and on water at a speed of 8 km/h.
The armored vehicle was developed on the basis of the Soviet-made BRDM armored car for reconnaissance and patrolling.
Source: Russian newspaper
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FORT MYERS, Fla. — In tonight’s Positively Southwest Florida, we’re celebrating a big win concerning one of my favorite things…pizza!
Earl Norris from Fine Folk Pizza in Fort Myers just won the 2019 Caputo Cup for non-traditional pizza in Atlantic City.
His pie placed 1st amongst some of the biggest names in the pizza industry across the country.
His pizza had a creamy base of blended cream cheese and sour cream, topped with mozzarella cheese, sliced zucchini, sliced almonds, and ricotta-filled squash blossoms.
This is the second year Fine Folk Pizza has brought home the Caputo Cup to Fort Myers.


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Manchester City boss Pep Guardiola, has not ruled out the return of Joe Hart in the squad during the summer.
Manchester City boss Pep Guardiola last summer removed Joe Hart from the team, he was loaned to Torino. But, instead of the English goalkeeper he transferred Claudio Bravo from Barcelona.
But it seems that the Spanish tactician was wrong with this decision, because Bravo has ended on the bench after his poor performances this season.
Former Barcelona and Bayern Munich coach has not ruled out the return of Joe Hart in the squad this summer.
“At the end of the season we will talk to players who are on loan. We follow all players who are playing. We also follow Joe Hart every weekend,” Guardiola said.