A look inside the newly opened Harpeth Hotel in downtown Franklin
Kimberly Elder walked down the steps into the courtyard at the newly opened Harpeth Hotel.
The rooms above her looked out onto the vast area, which led into the lobby. Doors quietly opened on the first downtown hotel in late November.
"We want this to feel like you're walking into Franklin's living room," said Elder, the sales director of the hotel.
Artwork depicting scenes in Williamson County and downtown Franklin dotted the walls of the halls and library. Large windows opened up to Main Street in the Riverside and Maury boardrooms.
"Every little detail has been thought out inside our doors for this mix of contemporary yet traditional look," manager Justin Foster said.
Acting like bookends to the hotel, McGavock's Coffee Bar and Provisions offers a mix of bakery goods, breakfast items and a lunch menu. The 1799 Kitchen and Cocktails offers American cuisine with twists from chef Jay Swift. While the bar has a variety of spirits, the eatery also focuses on whiskey, with more than 35 small-batch and single-barrel offerings. During the weekend, the restaurant also hosts a Southern-inspired brunch.
Those wanting to stay in one of the 119 rooms have options of a king size bed or a room with two queens. Rooms cost $258 per night on average.
Encircling First and Second avenues, and Bridge and Main streets, the Harpeth Square development will include residential spaces, businesses and the Harpeth Hotel, which is part of Hilton’s brand of unique boutique hotels.
Developers have planned a 591-space parking garage beside it. Parking starts at $2 per hour for public spaces. Tenants in the residential spaces will start moving in mid-January. Other retailers in the building are expected to open in the first quarter of 2020. The Landmark Bank building — at 198 E. Main St. — has also started its renovation.
Crews broke ground on the project in October 2017.
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Reach Emily West at email@example.com or 615-613-1380 and on Twitter at @emwest22.


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Super-selective Intra-arterial Cerebral Infusion of Trastuzumab for the Treatment of Cerebral Metastases of HER2/Neu Positive Breast Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02571530|
Recruitment Status : Recruiting
First Posted : October 8, 2015
Last Update Posted : May 17, 2019
The purpose of this study is to evaluate the safety of administering a single dose of trastuzumab into the artery for the treatment of brain metastasis(es) from HER2/neu positive breast cancer.
This study will try to determine the best tolerated single dosage of trastuzumab administered into arteries by gradually increasing the dosage given to participants as the study progresses. Early participants will receive a dosage of 1 mg/kg. As more participants enroll into the study, this single dosage will be increased at designated levels up to 8 mg/kg, if it's determined to be safe to increase.
Trastuzumab is a type of antibody, which is a protein used by the body's immune system to fight against pathogens such as bacteria and viruses. This antibody binds to cell receptors known as the HER2/neu tyrosine kinase receptor. These receptors are expressed in certain cancer subtypes such as breast cancer. By blocking signaling through this HER2/neu receptor, trastuzumab can slow down or stop the over-expression of the HER2/neu protein. Over-expression of HER2/neu has been shown to play a role in the development and progression of certain types of breast cancer. Therefore, by slowing down or stopping the expression of HER2/neu, investigators hope to slow down or stop the growth of metastasis(es) and increase the responsiveness to therapy.
|Condition or disease||Intervention/treatment||Phase|
|Neoplasm Metastasis||Drug: Intra-arterial Cerebral Infusion of Trastuzumab||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||48 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Phase 1 Trial of Super-selective Intra-arterial Cerebral Infusion of Trastuzumab After Blood-Brain Barrier Disruption for the Treatment of Cerebral Metastases of HER2/Neu Positive Breast Cancer|
|Study Start Date :||September 2015|
|Estimated Primary Completion Date :||September 2021|
|Study Completion Date :||September 2021|
Experimental: Intra-arterial Cerebral Infusion of Trastuzumab
Super-selective Intra-arterial Cerebral Infusion of Trastuzumab After Blood-Brain Barrier Disruption
Drug: Intra-arterial Cerebral Infusion of Trastuzumab
- Maximum tolerated dose (MTD) [ Time Frame: 30 days ]Maximum tolerated dose (MTD) the highest dose at which there are no dose limiting toxicities.
- Adverse events and dose-limiting toxicities [ Time Frame: 30 days ]A dose-limiting toxicity (DLT) will be defined as any grade 3 or 4 NCI Common Toxicity Criteria adverse event (CTCAE V4.0).
- Response Evaluation Criteria in Solid Tumors (RECIST) [ Time Frame: 1 year ]RECIST Criteria
- Overall Survival (OS) [ Time Frame: 1 year ]
- Intracranial Time to Progression [ Time Frame: 1 year ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02571530
|Contact: John Boockvar, MD||212-434-3900|
|Contact: Tamika Wong, MPHemail@example.com|
|United States, New York|
|Lenox Hill Brain Tumor Center||Recruiting|
|New York, New York, United States, 10075|
|Contact: John Boockvar, MD 212-434-3900|
|Contact: Tamika Wong, MPH 212-434-4836 firstname.lastname@example.org|
|Principal Investigator: John Boockvar, MD|
|Sub-Investigator: Jonathan Knisely, MD|
|Sub-Investigator: David Langer, MD|
|Sub-Investigator: Rafael Ortiz, MD|
|Sub-Investigator: Sherese Fralin, NP|
|Sub-Investigator: Ashley Ray, NP|
|Sub-Investigator: Karissa Tan, NP|
|Sub-Investigator: Tamika Wong, MPH|

domain: medical


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text:
LeeAnn Gaunt, chief of the SEC's Public Finance Abuse Unit
Paul Maco, partner with Bracewell in Washington, D.C.
Elaine Greenberg, shareholder with Greenberg Traurig in Washington, D.C.
Michael Decker, managing director and co-head of municipal securities for the Securities Industry and Financial Markets Association
Susan Gaffney, executive director of the National Association of Municipal Advisors
Ernesto Lanza, senior counsel with Clark Hill in Washington, D.C.
Emily Brock, director of the Government Finance Officers Association's federal liaison center
Leo Karwejna, chief compliance officer with The PFM Group

domain: economics


text:
LUCKNOW: Reviewing implementation of the second phase of Mission Shakti, Chief Minister Yogi Adityanath on Tuesday gave directions that registration of Gharauni, the document that will certify ownership of a residential accommodation in rural areas, will be issued in the name of a woman in the family.
The CM has also ordered setting up of an outpost under the Mahila Thana of the district for speedy redressal of complaints lodged by women. He also said that women self-help groups should be given the charge of maintaining community toilets in rural areas at the earliest.
The CM said that to celebrate International Women’s Day on March 8, government departments should start programmes under Mission Shakti from February 26.
The discussion also focused on the women cyber crime cell, cyberbullying and cyber stalking, setting up a woman safety committee under community policing, facility for first aid at women help desks, release of very old inmates from jail or those who are physically disabled, etc.
The CM directed district magistrates to prepare a road map for the next year to continue the programme even after April 2021.
“Women and girls still suffer discrimination and gender inequality. Effective communication helps overcome these situations,” said Manoj Kumar Rai, director, women welfare department and nodal officer, Mission Shakti. He said that a special social and behavioural change communication module has been prepared and public awareness programmes will be conducted through this in March.
Rai said women and children will be made aware of the role of effective communication in the fight for their rights. A training of departmental officers and employees will be conducted from March 1 to 10 on the basis of the communication module. One member each from the child protection unit of every district, one from each Mahila Shakti Kendra and four mukhya sevikas from each district will also be trained. Master trainers will then impart training to other departmental officers and employees between March 10 and 31.

domain: law


text:
HELSINKI – China's Changes 4 land and rover spacecraft successfully entered the moon shift Wednesday (December 12) after a four and a half day flight to the moon.
The spacecraft stepped into an elliptic moon's polar circuit with a danger of 62 miles (100 kilometers) at. 15:45 EST (0845 GMT) December 12 after a burnout of the end of the month.
The spacecraft's only major fire extinguisher fired 80 km (129 km) away from the moon following the release of a command from the Beijing Aerospace Command and Control Center (BACC) at. 3:39 AM EST (0839 GMT). [China’s Chang’e 4 Moon Far Side Mission in Pictures]
The China Lunar Exploration Project (CLEP) announced the success of the decisive brake maneuver within minutes, confirming that the spacecraft worked well and will begin preparations for relay satellite communication tests and refining its lane.
Chang 4 was launched by a March 3B portable rocket from Xichang Satellite Launch Center, southwest China, at 1:23. EST (1823 GMT) on December 7th for a 110 hour trip to the moon.
Three lane correction maneuvers were planned for the lane, but only one, performed December 9, was required, as the first and last maneuvers were considered unnecessary and thus canceled.
Comprising a lander and robber, spacecraft will try the first ever soft landing on the landing side – due to the tide of land never facing the ground – in early 2019.
Lander and rover are equipped with cameras and science to analyze the moon's surface geology and subsoil, solar wind interactions, and make low-frequency radio observations in the unique radio-calmed environment on the landing side.
Communication with spacecraft will be facilitated using the "Queqiao" relay satellite launched in May and then inserted in a halo around the Earth's Lagrange Point, about 40,000 to 53,000 miles (65,000 to 85,000km) beyond the moon.
Longer landing and science
The landing will target candidate landing sites in the South Pole-Aitken Basin (SPA), where the chosen place is understood, but not officially announced, to be the 116 kilometer long (186km) Von Kármán crater.
The South Pole-Aitken Basin is a 1,550 km wide (2,500 km), 7.5 km deep (12 km) old battlefields of intense scientific interest that could contain exposed material from the top of the moon and track the history and development of the Moon.
James Head, a planetary scientist at the Brown University's Department of Earth, Environment and Planetary Sciences in Providence, Rhode Island, told SpaceNews that instruments like Lunar Penetrating Radar also abandon China's former Chang's 3-moon mission will provide images of the structure of the Earth's soil and any underground low-flow units and any embedded soils and "help us understand the three-dimensional nature and extent of sub-soil units".
Head stated that the payload Visible and Near Infrared Imaging Spectrometer (VNIS) is also of very high interest and will allow comparisons between mineralogy in the South Pol Aitken Basin of nearby units and help answer questions such as: South Pole Aitken Basin Impact penetrates the mooncap?
No official date has been released for landing attempted drive descent, but China Aerospace Science and Technology Corporation (CASC), the main space contractor of the Chinese space program, announced shortly after launch that landing will take place in the first days of January 2019 after sunrise over the main candidate landing within the Von Kármán crater at the end of December.
Chang 4 was originally planned as a reserve for Chang's 3 lander and rover mission, which in December 2013 made China a third country to achieve a soft landing on the moon's surface and the first since the Soviet Union's Luna 24 in 1976th
The lander has a dry mass of 2,650 lbs. (1,200 kg) and carry 310 lb. (140 kg) rover. At launch when it was loaded with propellant, the spacecraft weighed about 8,380 lbs. (3,800 kg).
Chang's 4 mission is to be followed by China's first trial return mission, Chang 5, which could launch at the end of 2019 on a rocket in March 5.
This story was provided by SpaceNews, dedicated to covering all aspects of the space industry.

domain: geography