text:
Movies, mountains and a Colorado summer evening sky. It doesn’t get much better. This summer movie series may not be the most convenient for families in Denver or Boulder. However, if you’re planning a summer weekend road trip, you might make this unique experience a stop for some family fun and memories. (Steamboat Springs is about 150 miles from Denver or roughly three hours. Pack some snacks, blare your favorite tunes and you’re ready to go!)
Grab a seat under the stars and stretch out for a featured film on the mountain side, thanks to Steamboat Springs’ Movies On The Mountain series. (By the way, the series is sponsored by Coca-Cola.)
Movies are shown Saturday nights beginning at sunset on the Steamboat Stage in Gondola Square. Bring your own lawn chairs and blankets. Snacks and beverages are available for purchase. Please, leave pets at home.
Here’s the schedule:
June 29 – Mamma Mia! Here We Go Again at 8:55 p.m.
July 6 – Smallfoot at 8:55 p.m.
July 13 – Indiana Jones and the Temple of Doom at 8:50 p.m.
July 20 – Ralph Breaks the Internet at 8:45 p.m.
August 3 – The Goonies at 8:35 p.m.
August 10 – Mary Poppins Returns at 8:25 p.m.
August 17 – Fantastic Beasts: The Crimes of Grindelwald at 8:15 p.m.
August 24 – Captain Marvel at 8:05 p.m.
August 31 – Dumbo at 7:55 p.m.

domain: travel


Product OverviewCloud Supply Chain Management is all about managing the supply chain cycle within an organization that is present in flexible locations, with cloud or Internet of Things (IoT) data, analytics, and decision-making all taking place. There is a need for data and computing to be focused on the cloud in this era of complex business and large coverage and globalization of trade and services, i.e. resources are present at a location and can be used when needed. In other words, computing on a wide scale is where utilities ar
Pudya.com is a popular social bookmarking site that absolutely free of use. Users can publish their blogging articles, business articles, corporate news, products offer, new products, jobs information, travel news, food news, entertainment news, and services they offer.


text:
Dr. Eric Ash, MD, practices Family Practice in Perry, IA at Mercy Family Care Perry. Dr. Ash received his medical degree from University of Iowa School of Medicine.
Specialty: Family Practice
View doctors who practice Family Practice in Perry
Years of Experience: 26
Dr. Eric Ash has been rated by his patients 3 times. His last rating was on April, 7, 2010. View ratings for Dr. Eric Ash.

domain: medical


text:
by Jesse Sposato
Medically Reviewed by:
Francis Kuehnle, MSN, RN-BC
by Jesse Sposato
Medically Reviewed by:
Francis Kuehnle, MSN, RN-BC
The increased openness in talking about depression has mostly been positive — but is there a downside?
When Ashley Tully was in one of her deepest bouts of depression, she found it helpful to listen to others share their own stories of depression: why they got depressed, what their lowest point looked like, if and how they got better, and who was particularly supportive during the process.
“I think [that] common experience, it helps you feel less alone,” says Tully, an agriculture specialist and educator living in Livingston Manor, New York. She listened to these stories mostly on podcasts, which were easy to access but offered distance.
“Because it’s safe, right?” she explains. “In some ways, you’re still not ready to open up, but you can take in this information without being vulnerable or exposing yourself or risking your safety.”
The fact that these podcasts even exist to potentially make people feel less alone — Terrible, Thanks for Asking and Mental among them — is part of a greater awareness of depression and mental health that’s taken place in the last couple of years.
Depression, self-harm, and suicide is rising among American adolescents, in particular among LGBTQIA+ youth; and among adults, the national rate of suicidal ideation has increased every year since 2011.
So, if these issues are in the spotlight now more than ever, why is the state of people’s mental health worsening? And what does it mean for people who have been living with depression all along?
Having removed a lot of the protective factors that were keeping people afloat pre-pandemic (being in community, in-person services, and more), it’s easy to understand why mental health has worsened as a result of the pandemic. But it’s hard to say whether mental health was also worsening prior or people are just willing to be more open about it now.
“Has depression increased? I don’t know,” says Laryssa M. Creswell, a licensed clinical professional counselor based in Edgewater, Maryland. “I think that, because the light has been shined on it, we’re seeing it more and we’re just more aware of it.”
She likens it to police violence against Black people. “Has there been an increase in the way in which police officers have treated Black people? Not necessarily. It’s just that it’s been recorded,” she says.
Karina Solis, a licensed mental health counselor at Thriveworks in Somerville, Massachusetts, agrees. “I think it’s always been there,” she says. “It’s just now coming out to the open.”
I wish there was more discussion on failures … We always talk about the success and the thing that made you a millionaire. And I think that sets a bar that’s unrealistic and very unhelpful for one’s mental health.
— Rachael Lee Hyatt, LCSW
As to why we’re seeing such a high rate of depression right now, Rachael Lee Hyatt, a licensed clinical social worker based in Brooklyn, New York, points a figure to social media, for one.
She now sees Instagram as a curated platform largely used by professional influencers. But before that, it was more everyday people sharing their lives, and there was a lot of, “Let me show you what I’m doing, and how glorious and fantastic and perfect it is,” she says. “And I think that created this space of massive comparison and massive pressure to be better, to have this really fabulous and glamorous life that everyone was posting about.”
Hyatt started to observe her clients, who range in age from their 20s to their 40s, becoming increasingly self-conscious, caring more about what other people thought, and feeling like their lives weren’t as “fabulous” as they should be.
“That’s a really easy space to start feeling very depressed and feeling like, ‘I’m not good enough,’ ‘I can’t do this’ or, ‘My life doesn’t look like this, so I must not be enough,’” she says.
Creswell agrees that social media is a factor, but believes that it doesn’t stop there. She sees advances in technology across the board as having exacerbated the problem.
“What they have on their plates just didn’t exist … 30 years ago,” she says speaking about adolescents, in particular, a population she specializes in. She’s talking about having 24/7 access to information, whether via social media, smartphones, TV, or the news.
Creswell brings up bullying as an example of how constant access has altered the landscape for the worse. “[In the past], if you were being bullied at school,” she says, “it stopped once you left because they only had access to you while you were at school …[But now], it doesn’t stop. It’s a constant — they can continue to come for you all day, all night if they want to.”
She adds, “What teenagers are challenged with now is way different than what it was before. And so, while we are seemingly more connected, we are less connected in a sense.”
Another factor Hyatt thinks plays a role in fueling depression is societal pressure to be perfect.
“It can fuel really severe depression. If we feel like we have to be perfect, then nothing that we do is ever perfect [enough], and then we get very depressed,” she says. “And then with severe depression, you don’t do anything because it’s not going to be perfect.”
On a related note, she also thinks there’s a collective pressure right now to focus on end results rather than process, which helps contribute to the problem. She sees this as stemming all the way back to grade school — for example, the idea that “I don’t care how hard you studied for the test or how much you learned, I only care if you got an A.”
“I wish there was more discussion on failures. Failing is not a bad thing. I wish we could celebrate it a little bit more,” she says. “But we always talk about the success and the thing that made you a millionaire. And I think that sets a bar that’s unrealistic and very unhelpful for one’s mental health.”
You have so many celebrities talking about postpartum depression, experiences with depression during grief … There’s so much more room to just take up space and say, ‘My mental health is not great.’
— Imadé Nibokun
Almost everyone I spoke with agreed that, yes, they’ve definitely noticed more of an openness in talking about depression and a willingness to seek out therapy — and that, for the most part, it’s a good thing.
Creswell and Hyatt have both observed their clients being more casually open about therapy and depression with friends and even strangers.
“I have some teens, they’re like, ‘Yeah … I was talking to my therapist,’ and it’s like they’re just going out for coffee or something,” Creswell says, “whereas at least during my time, to say that you’re going to see a therapist was like, ‘Oh, you must be crazy.’”
Knowing that’s how people would respond was a major deterrent to saying anything, so people would often keep it to themselves, Creswell explains. “But the teens of today, they’re like, ‘I have a therapist, and you should get a therapist, too!’”
She thinks there’s still work to be done, but she says recent progress has been effective in getting people to be more open, which can only be good.
“That leads to us talking about it, right? Because otherwise, we’re working in silos,” she says. “I think the thing is to keep the atmosphere of that sense of safety where it is OK for me to be able to talk about it.”
Hyatt sees this increased openness almost as a permission slip for others to share their own stories and seek help themselves.
“If you feel like you’re the only one, it’s just gonna [drive] you further into feeling depressed. And so if it feels a little bit more normalized, like, I’m not the only one and there are other people that deal with it,” Hyatt says, “I think that’s really positive for individuals, and for our community as a whole.”
Solis has seen this play out in her own practice. “There are so many clients who will say, ‘I’ve always thought about this, but I never wanted to go to therapy because I didn’t want people to think that there was an issue with me,’” she says.
Now that they’ve seen the stigma dissipate, “people can seek the help that they need.”
She wishes this shift would have taken place 20 or 30 years ago, but she’s glad it’s happening at all. “For everything, we have to start somewhere,” she says.
Imadé Nibokun runs the nonprofit Depressed While Black (which donates Black-affirming personal care items to psychiatric patients), and she lives with major depressive disorder and borderline personality disorder. Nibokun thinks the fact that everyone is talking about it makes it “the easiest time to say that you deal with depression or anxiety as a Black person.”
Nibokun adds, “You have so many celebrities talking about postpartum depression, experiences with depression during grief … There’s so much more room to just take up space and say, ‘My mental health is not great.’”
That being said, Nibokun feels the narrative that’s being shared most prominently is a bit too one-note. It’s very much like, “I had depression for a short period of time — and now it’s over,” she says. “So, we do need more depictions of chronic mental illness, not just the ‘I overcame’ stories.”
Many people don’t “overcome” depression. Major depressive disorder affects more than 16 million adults in the United States in a given year, Nibokun included.
She does point to one exception, though, that she’s noticed: the show “Crazy Ex-Girlfriend.” Nibokun feels that, when it comes to telling stories about mental illness and depression, in addition to the “I overcame” narratives, it’s the “cute stories” that usually get centered, as opposed to the messier, more complicated stories.
“In ‘Crazy Ex-Girlfriend,’ she is difficult and she’s challenging to deal with,” she says, “and I thought it was such a game-changer, and it really humanized folks and normalized people who have severe mental health conditions outside of depression and anxiety.”
However, yet again, there’s social media. While Hyatt thinks it’s helpful to have social accounts where people talk about mental health — these accounts increase awareness and help people identify unprocessed emotions — she worries that some people may take what they read on these accounts as gospel, which could be problematic.
“Treating mental health is very much an individualized thing. We all suffer for very, very different reasons,” she says. “And so I think, if we try to say, ‘I can just read this stuff online,’ or, ‘I follow this one person on TikTok or Instagram and that’s my therapy,’ I think that’s the only space for it to not be helpful.”
Tully, who also agrees that the increased attention is positive overall, and has clearly benefited from it herself, admits that she can imagine people who are severely depressed feeling like the conversation isn’t about them.
“There’s always this learning curve of change,” she says, so that that may be true, “but that doesn’t mean this isn’t still the path towards progress, which is openness.”
The hope is that this is just the beginning.
“I want the conversation to be bigger … We can’t decide to only help one portion of society who needs help … and then call it a success.”
— Nicolette Lafonseca
Tully is onto something, though, in thinking that everyone may not feel included in the conversation. Nibokun, for instance, does not feel included. She feels like the “anti-mental health stigma movement” focuses only on people with mild mental health conditions, often the same people with the “I overcame” stories.
“It assumes that you’re mentally well enough to call 50 therapists to see if they’re taking new clients,” she says.
If you’re at an extremely low point, you might not be able to get out of bed, let alone try to seek help at a time when help is notoriously difficult to find.
Nicolette Lafonseca, who owns the sustainable concept shop Le Weekend and lives in Cornhole, Yorkshire, sees it this way, too.
“If we’re always shown success stories or stories of mental health where it …has a happy ending, then people who haven’t got a light at the end of the tunnel are going to feel like a failure,” says Lafonseca, who has been diagnosed with bipolar disorder with psychosis and schizophrenia.
She has spoken to others with long-term mental illnesses like herself who also feel like there’s no place for them in the conversation because the stories they have to share seem too dark and too scary for many.
“I think that mental health has become sanitized into something that we can manage, that marketing can get behind, that they can [use to] promote their mindfulness app or their scented candle,” she says. “I have psychosis. I’m not going to be fixed with a scented candle.”
Lafonseca explains this does not negate the suffering of anyone living with less severe conditions.
“We’re not grading on a curve. Your grief is your grief,” she says. “And it’s huge, and it’s yours, and you own it …We’re not playing ‘mine’s bigger than yours,’ because that doesn’t get anyone anywhere.”
She does, however, feel that people should do a better job of being inclusive. No matter if they’re talking about someone living with chronic depression or someone who experiences postnatal depression, which often comes with an end date, there shouldn’t be a hierarchy of which matters more.
“They’re all important,” Lafonseca says, “but there needs to be a place for everybody at the table.”
She adds, “I want the conversation to be bigger … We can’t decide to only help one portion of society who needs help … and then call it a success.”
It would be an understatement to say that the pandemic shifted people’s lives in many fundamental ways, and therapy is no exception. Nibokun, who found her current therapist, whom she loves, on Psychology Today, points out that the pandemic allowed her to open up her therapist search to the entire state. As someone looking for a Black therapist qualified to treat her specific diagnoses, this was huge for her.
“Having somebody who I can speak to virtually, beyond the limited number of therapists in my city,” she says, “it’s just a game-changer. And I hope that more people with severe mental health conditions take advantage of that.”
Online therapy, Hyatt adds, has also been incredibly helpful for people who don’t have the time to travel (maybe because of work or kids), or who live in more rural places and don’t have many therapists nearby. But, she says, the openness we’ve been talking about, plus the anxiety the pandemic has added, has naturally led to a “big increase of people saying, ‘Actually, I do want to talk about mental health.’”
This is great, but it has led to a shortage of sorts.
“I think it’s really good that … it’s more accessible. You can do it from your home, you can get [therapy] on your lunch break. But at the same time, there’s more demand,” she says. “It’s been really hard to even have space to accept new clients.”
Plus, Hyatt points to the elephant in the room: the financial piece of it. The unfortunate reality is that “it’s just too expensive for a lot of people to be able to prioritize it,” she says.
Creswell, who spent the majority of her career working in community mental health and at a psychiatric hospital, seconds this. “The population is just totally different in terms of being able to access the treatment,” she says.
She talks about lower-income families, who are more likely to have to depend on community mental health, “which is totally fine,” she says, “there are great clinicians working in that field,” but that’s not the only factor.
“You also run up against availability — do they have enough therapists in that particular facility? And then, can the clients make it there, or do they have to find transportation to get there?” she explains.
There are all these other barriers that can come into play. But with the population she currently sees in her private practice, “their ability financially to access the treatment is greater.”
The increase in demand has also led to the market being flooded with traditional therapy alternatives, which some say can’t possibly do what they claim, and others say they’re left out of entirely.
Before Nibokun found her current therapist, she tried one of the therapy apps. “The moment I said I deal with chronic suicidal ideation,” she says, “they were like, ‘Here’s your suicide prevention number.’” So Nibokun dropped her.
This brings us back to the people this increased awareness — and the increased services that have come out of it — includes and helps.
Nibokun is hopeful that this increased public awareness and acceptance of mental health issues will start to expand to her and others who deal with similar serious conditions. She feels like those with larger platforms can help move the needle forward.
“The more that celebrities disclose their schizophrenia, their bipolar, their mental health conditions … outside of [just] depression and anxiety,” she says, “I do think it will be a cultural shift.”
She also wishes for an expansion of peer respite centers, supportive environments where people can go to wait out their mental health crises, “where they have the ability to have agency and self-determination.”
Nibokun sees this as an improvement from being placed in facilities you can’t leave, which can be a real disruption to everyday life.
An increase in mental health first responders, too, when it comes to crises involving mental health conditions, addiction, and more, is key (essentially what the defund the police movement largely focuses on). This has been happening across the country in places like Denver and Oakland.
Nibokun points to the Cahoots program as a successful model in Oregon. We should “treat mental illness the way we treat heart attacks,” she says. “We don’t send the police when somebody has a heart attack. We send EMTs.”
Everyone I spoke with agreed that better funding and improved healthcare would be instrumental in creating a world in which patients didn’t have to choose a mere two sessions a month based on their budget, and therapists could take on any client, no matter their insurance reimbursement, while also being guaranteed a fair wage themselves.
“Those who are in the lower-income community should be able to receive the same type of treatment, as those who have million-dollar-and-above incomes,” Creswell says. “It should be the same across the board.”
And for the million-dollar question: How do we get there? Creswell suggests lobbying your congresspeople, and saying what you need, what you want, and what your community needs — and then holding them accountable. She talks about the importance of voting, not just every four years in presidential elections, but also in smaller elections in your community.
“It’s building, and getting the people in who you want,” she says, adding that reaching out to professional organizations such as the American Counseling Association and the American Psychiatric Association, and telling them what you need helps, too.
“They listen, they look for that,” she says, emphasizing the sheer importance of numbers. “The more people that are doing it and saying it, the greater likelihood [you have of] seeing what you want done.”
Creswell is also a firm believer of giving a voice to the voiceless, particularly when it comes to people of color and the LGBTQIA+ community, with whom she works closely. “The more that you can … find them and talk to them and print what they have to say, that’s huge,” she says.
Some who have lived with depression for a long time may be wondering why this is all so important now when it’s something that has been a priority to them for so many years.
Creswell’s response to that is: “Why not now?”
She continues, “At least in my years, that’s been the point.” She’s referring to all the calls she’s made to Congress members, the times she’s gone to Capitol Hill to advocate for patients, and all the things she and so many others like her have done to boost awareness about depression and mental health over the years.
“It finally caught fire,” she says, “so, now that it’s here, let’s embrace it, and let’s do all that we can, while we can.”
Medically reviewed on July 01, 2022
Have thoughts or suggestions about this article? Email us at email@example.com.
About the author
Jesse Sposato (she/her) is a journalist, essayist, and editor living in the Catskills. She likes to write and edit stories about social issues, feminism, health and wellness, culture, friendship, and grief. Jesse is currently the deputy editor of client projects at Narratively; she’s also working on a grief memoir and a collection of essays about coming of age in the suburbs. Her writing has appeared in InStyle, Shondaland, and Refinery29, among many others. You can learn more on her website.

domain: news


text:
Stay up to date
with our latest news!
Our Gazette is a virtual place of real news about what happens every day in Cantiere Galli, the latest new developments of our partners, the design projects that reflect our passions and interests. If you want to take part in our events, do not miss a single post, and follow us on the social networks.
“There is nothing deeper than what appears on the surface“! We gladly do ours the Hegelian philosophy because at best it expresses the importance of a material, whose essence lies precisely in its tangible, emotional being in its concreteness!
It is with this spirit and this irony that we present the last event that Cantiere Galli Design had the pleasure of hosting last February 28th.
First of a series of three events that will enrich our initiatives in 2019: VERY MATERIAL PEOPLE is the name of the format conceived and curated by Francesca Romana Straffi. Eclectic architect and creative with taste and passion, FRS deals with multiple scenarios in the field of lifestyle, interior design, fashion and communication. She is dedicated to the creation of projects – events that she defines as “experiences” that aim to consolidate the relationships between brand and audience. It is the involvement and the thrill of the secrets for the success of an event!
All Very Material People events will be dedicated to materials to celebrate the work of research, selection and consultancy in the world of interior that Cantiere Galli Design carries on with passion and constancy. The first of the three, “The Glass Night“, last February 28th was dedicated to glass, a noble protagonist and one of the most interesting materials for architecture and design, for its ability to be versatile, malleable, thin, resistant and fascinating and, last but not least, for its transparency.
Partner of the event, Mutaforma, which fits perfectly with the vocation of the evening. It is one of the companies of excellence that has been able to renew the capabilities of a material such as glass through the use of new technologies and strong research. Mutaforma creates a micro mosaic, thanks to the use of nanotechnologies, with a great personalization and an extraordinary aesthetic capacity.
An evening of Champagne, poured into the glasses of the fferrone, another partner chosen specifically for The glass night. An international brand based in Chicago, the fferrone produces elegant and extravagant objects (glasses in this case), alternating classic and opulent shapes with others that are more rigorous and minimalist, precisely of timeless objects-jewel for refinement and preciousness.
And to complete the whole could not miss the good food, a menu for the proposed occasion and prepared at Cantiere Galli Design by Chef Max Mariola.
What will be the next protagonist material? Waiting for Very Material People!
ph. credit Lorenzo Catena

domain: artistic


| Aug 5, 2013
| 5:14 PM
Despite the industrial train tracks about 100 feet beyond her back fence, Laurie Weishorn's neat, tree-lined backyard in Southwest Baltimore can seem like an oasis of suburban quiet on a low-humidity summer afternoon.
After 22 years in Morrell Park,...
| Aug 9, 2013
| 9:18 PM
The port of Baltimore logged a number of successes in recent days: a record-breaking year for the amount of cargo handled, state exports surging to $6 billion in the first half of this year and more federal funding to support shipbuilding jobs.
| Dec 27, 2013
| 7:19 AM
The Maryland Department of Transportation is reporting that a multi-vehicle accident on southbound I-95 in Harford County prior to Churchville Road this morning has been cleared. Elsewhere, there's roadwork being conducted on I-95 just prior to the...
| Dec 27, 2013
| 4:43 AM
The Maryland Department of Transportation is reporting that the JFX is cleared after accidents affected flow earlier this morning. One accident had closed all three southbound lanes near Northern Parkway, but everything is reportedly clear as of 7:45 a.m....
| Jan 3, 2014
| 5:47 AM
On a morning when many people woke up to three to six inches of snow, the Maryland Department of Transportation is reporting several incidents at 7:45 a.m., the most serious being a utility incident in the city on Washington Boulevard at Bush Street...
| Jan 6, 2014
| 4:30 PM
Officials in Maryland don't know how feasible it is to turn dredged muck from the bottom of Baltimore's shipping channels into a commercially viable construction material — but they are looking to find out.
The Maryland Department of Transportation...
| Nov 6, 2013
| 9:54 AM
The Board of Public Works gave its blessing Wednesday to an O'Malley administration plan to contract with a private sector partner to build, operate and help finance a $2.2 billion light rail line in the Washington suburbs.
The board action clears the...
| Nov 15, 2013
| 2:22 PM
Officials in Maryland want disadvantaged local residents to fill thousands of construction jobs as two major transit projects come online in Baltimore and the Washington suburbs in coming years, and are handing out grant money to get them trained.
| Nov 18, 2013
| 4:34 PM
Leaders of Maryland's transportation industry said Monday that the state's future depends on continued infrastructure investment, beyond the $4.4 billion already scheduled for highway and mass transit systems in the next six years.
| Nov 19, 2013
| 6:29 AM
At 9:30 a.m. the Maryland Department of Transportation is reporting that the accident involving three vehicles on I-895 south at the Harbor Tunnel has been cleared, but officials are warning commuters to use caution, and expect delays until the backup...
| Nov 25, 2013
| 11:33 AM
The Maryland Transportation Authority has named Bruce W. Gartner its executive secretary, effective Dec. 11, following seven months of his acting in the role.
Gartner, 48, temporarily filled the agency's top position in June for former executive...


text:
The Gujarat High Court today rejected a public interest litigation challenging the 'soft loan' given to Tatas for the Nano plant in Sanand in the district, as well as the land allocation.
The bench of Chief Justice Bhaskar Bhattacharya and Justice J B Pardiwala also sought replies from the state government and the Centre.
Guj HC today issued notices to the Govt of India, Fin Secy, IRDA including LIC, over a public interest litigation alleging 'corrupt practices'.
A division bench said the Commission refused to allow Bhatt to inspect the records without being aware of the High Court's October 2012 order.
Admitting a PIL alleging charging of unauthorised deposits from consumers with domestic PNG connection, the Guj HC issued notices to Adani Gas Ltd.
The High Court also directed the Commission to provide Bhat access to those documents by Friday.

domain: law


text:
A continued effort to legalize the unrestricted access and use of marijuana in the U.S., primarily through voter initiatives, continues in spite of clinical trial evidence of lack of efficacy, increasing teen use, and reports of serious consequences from accidents to mental illness.
As marijuana is currently viewed by the public as “safe until proven dangerous” rather than dangerous until proven safe and effective, by way of randomized double blind clinical trials for a specific medical problem, we cannot make any claims regarding its medical benefit.
Risk of Psychosis
Little is known about the long-term effects of marijuana use as concern rises regarding the impact on the developing brains of young initiates. The effect of the psychoactive ingredient in cannabis, Δ9- tetrahydrocannabinol (THC) on subcortical neuronal connectivity and function is the most recent concern as increased prevalence of psychiatric morbidity have been reported in the medical literature— including depression, suicidality, panic, paranoia, amotivation, increased risk for psychosis and now, a six-fold increase in the risk of schizophrenia among the youngest initiates.
These deleterious outcomes have been reported for those using easily attainable, high potency cannabis products. The aforementioned risk factors remain after controlling for confounding variables. Why or where or how persistent use produces these effects, and who might be the most vulnerable are under study, but the answers may be too late for children and teens who are already abusing marijuana. The functional organization of the brain’s subcortical regions that are modulated by dopamine (DA) is associated with psychiatric disease but the genetic contribution and mechanism by which psychiatric symptoms emerge is not well-understood.
The authors of this important research suggest that individuals with marijuana use disorder are more likely to have genetically derived variants that result in abnormalities in striatal DA, including transcription errors in the Dopamine Receptor Dopamine 2 (DRD2) alleles. These individuals are at greater risk for various psychiatric morbidities, including psychosis, when compared with marijuana abusing persons without these genetic variants. Accordingly, the authors suggest that regular marijuana use is associated with altered resting-state functional connectivity in the midbrain and striatal DA circuitry.
This novel research consisted of assessing resting-state activity of the subcortical brain regions in 441 young adults from the Human Connectome Project, including 30 marijuana addicted subjects and 30 matched controls.
As hypothesized, localized functional connectivity density was most prominent in the amygdala, hippocampus, ventral striatum, dorsal midbrain, and posterior-ventral brainstem. Among marijuana addicted subjects, increased hubs of functional DA connectivity density were observed, relative to control subjects. These hubs were discovered in nuclei associated with DA activity including the ventral striatum where the nucleus accumbens is located, the midbrain where substantia nigra and ventral tegmental nuclei, where both peripheral and central DA are produced respectively, but also in the brainstem and lateral thalamus. These effects were observed in the absence of significant differences in subcortical DA volumes and were most pronounced among individuals who initiated marijuana use during early adolescence and were associated with elevated negative emotional states.
Why Does This Matter?
Although there is much to learn regarding the role of marijuana use and concurrent psychopathology, these findings support the hypothesis that prevention and early intervention for children and adolescents, young adults, and pregnant females is essential and a highly worthy goal. Bottom line is clear. Early onset and persistent, long-term marijuana use is associated with changes in resting-state brain function in the same dopaminergic nuclei and regions associated with brain reward, habit formulation and psychiatric illness, including psychosis.
Peter Manza, Dardo Tomasi, and Nora D. Volkow. Subcortical Local Functional Hyperconnectivity in Cannabis Dependence. Biological Psychiatry, 2018 (In Press) https://doi.org/10.1016/j.bpsc.2017.11.004

domain: literature


text: New York, August 12, 2014--The Committee to Protect Journalists calls on Ukrainian authorities to clarify the status of Andrei Stenin, the Russian photojournalist for the state news agency Rossiya Segodnya (previously RIA Novosti) who was reported missing on August 5 in eastern Ukraine. According to Russian news reports, Anton Gerashchenko, adviser to the head of Ukraine's Ministry of Internal Affairs, said Stenin had likely been detained by Ukraine's security service, or the SBU. Earlier, the SBU had denied holding Stenin. Gerashchenko also said that Stenin may be accused of "aiding and glorification of terrorism," the reports said. A short time later, Gerashchenko told Rossiya Segodnya that his comments had been taken out of context and that he was unaware of Stenin's whereabouts.


malinky: flower & iron
Flower & Iron
An old story, a new melody, a change of wording here and there to make the tale of a lovers’ conversation clear in the twenty first century -- those all set the scene in Pad the Road wi’ Me, the opening track on the Malinky’s latest album, Flower & Iron. It’s a fair representation of what they do as a group, as well --listen well to older songs, hear the melody and words clearly, and sing and play them in ways that stay completely true to the Celtic traditions from which they spring while being as fresh and conversational as a conversation with friends over the morning paper. The Scotland based group has been at this, with some line up changes, for ten years now, and this latest release finds them bidding fair for even better things as they start out on their second decade. Steve Byrne and Fiona Hunter hold the conversation in Pad the Road wi’ Me, and in addition to singing each brings creative instrumental skills to the group as well. Hunter is a cellist, and Byrne, one of the founding members, plays guitar, bouzouki, and several other instruments. Mark Dunlop, also a founder of the band, plays bodhran, whistles, and flute, and also sings, as do the the two newer members of the group, Mike Vass who plays fiddle and guitar, and Dave Wood who plays guitar and bouzouki.
That sounds like a lot of strings, you might think, and that’s indeed so -- the creative interweaving of all that is part of Malinky’s distinctive sound. Their song selection and arrangement here is creative, edgy, and thought provoking, too, all while in service to the tradition. There’s a lively instrumental set called Cows and Cottongrass, and a striking anti war song told from the view of a soldier’s children, called When Margaret was Eleven. Irish songwriter Liam Weldon is the source for Dark Horse on the Wind, which considers the human cost of politics from another perspective. It’s not all politics by any means, though, it’s just politics as a part of lives lived out. Those songs stand among twelve tracks next to that opener, where a man tries to persuade a reluctant woman to join her life with his. They all make a path to the closing cut, a gentle and very Scottish sounding song called The Road to Drumleman, which is a poem by Willie Mitchell set to to music by Tony Cuffe. The project was recorded by Jamie and Julia MacLean, and their dad, Dougie, writer of Caledonia among other songs, adds digeridoo to one track.
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I know my soul keens for the fun times and excellent dancing that abounds at our convivial and unique little show in the mysterious and tastefully appointed basement of everyone’s favorite jazz club.
Does your soul keen for such things as well, Gentle Portlander?
If so, then you’re in luck! Join us this Friday for the July edition of Offbeat! Woooo!
Our lineup features sparkling and dynamic returning champions:
We shall also be joined by two of my favorite local dancers:
And we are thrilled to announce a marvelous Offbeat debut performance (verily, Incisive Portlander, we are thrilled and glittering at the very thought of it)!
Join us this Friday for the Offbeat Belly Dance debut of:
Perhaps you’ve taken the belly dance basics class she teaches with Lisa Vavrek of Scarlet Thistle at 6pm on Sundays at Znama Dance?
If not, then you should definitely check them out, and join us this Friday to check out her enchanting Offbeat debut!
And we are beyond delighted to share the stage with a marvelously talented Portlander who currently hangs her hat in the faraway land of Boston – our very special guest:
Bevin Victoria Solmon aka Hybrid!
Yaaaaaaay! So excited to share the stage with this lineup, and to share the evening with you, charismatic patron of Portland’s underground belly dance scene 😀
Can you feel it, Zesty Portlander?
The sparkling anticipation of a night of amazing dancing?
The effervescent promise of the Blue Monk’s fine food and drink, the merry fellowship, the vivacious allskates?
The electric current of excitement that crackles in the very air that we breathe?
That’s the undeniable pull of Offbeat, beckoning you to come be a part of the magic, this Friday at the Blue Monk!
As always, the show is early (so convenient!)
As always, the show is free (a very good price!)
And as always, the show will be faaaaabulous (and will be rendered infinitely more so by your presence!)
Join us this Friday for good times and great dancing at Portland’s favorite monthly showcase of off-kilter awesomeness!
Viva Offbeat! Wooooo!
Hugz and sparklez,
Ringleader, Offbeat Belly Dance

domain: hobby


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Costa Rica has a lot to offer travellers looking for some adventure. The country boasts beautiful beaches, volcanoes, and plenty of other exciting attractions.
One of the best places to visit in Costa Rica is Tortuga Island, a tropical paradise that’s home to an amazing community of turtles. It’s a great place to relax and enjoy nature without the crowds.
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The northern Guanacaste region of Costa Rica is renowned for its sun-splashed beaches and Pacific surf. It also offers a diverse landscape with fascinating national parks, caldera volcanoes and hot springs.
With its beautiful beaches, a wealth of resorts and activities for all tastes, it’s no surprise that Guanacaste is one of the most popular places to visit in Costa Rica. It’s a popular choice for those who want to escape the cold of winter, but it’s also an ideal destination for travelers who are interested in exploring the area’s pristine nature.
There are a few great ways to experience the natural beauty of this region:
Hiking in the rainforest at Rincon de la Vieja Volcano National Park is an unforgettable experience, as is enjoying a relaxing mud bath at a local spa. If you’re looking for something a little different, the Llanos de Cortes waterfall near Liberia is an incredible experience that feels like a tropical oasis in the middle of the desert.
Another great option is Playa Hermosa, a secluded beach surrounded by palm trees and tranquil waters. Located on the Nicoya Peninsula, this beach is known for its world class yoga retreats and is one of the best places to see Olive Ridley sea turtles nesting in the area.
A dreamy paradise of turquoise water, sandy beaches and just the right balance between relaxation and a party vibe, Tortuga Island is one of Costa Rica’s top destinations. It can be reached by boat from Puntarenas, Montezuma and Jaco, and despite being smaller than its name suggests, it packs in a lot of fun and adventure into a single day.
The best way to visit Isla Tortuga is to take an organized tour. These offer a full day of everything from snorkeling to swimming, hiking, sunbathing and even some scuba diving!
There’s also plenty of wildlife to spot on Isla Tortuga, including red-backed squirrel monkeys, harpy eagles and white-lipped peccaries. Hiking trails wind through the forest, giving visitors a chance to get up close and personal with nature.
If you’re feeling hungry, most tours include a BBQ-style lunch. It’s a great way to sample some Costa Rican food and enjoy a delicious meal while on the island! You can even pick up some souvenirs along the way from tented shops scattered along the shore.
If you are looking for a beach vacation that offers a little bit of everything, Jaco is the place to go. You can spend your days relaxing on the pristine beaches and exploring the fascinating wildlife around town.
If you’re into adventure, there are lots of tours to do here, including a day trip to the amazing Carara National Park. This stunning rainforest is the most northern Pacific coastal national park in Costa Rica and is a great way to get out into nature and spot some wild animals while on your Costa Rican vacation!
Another popular option is a tour to Tortuga Island. It’s a popular spot for snorkeling and there are plenty of sea turtles and dolphins to see.
It’s easy to get wrapped up in the resort experience in Jaco, so make sure to sign up for some tours that take you outside of your hotel to enjoy some of this amazing area’s highlights. For example, you can take a short 25-minute drive north to the famous crocodile bridge over the Tarcoles River. Or check out the local surf competitions that are held in the area throughout the year!
One of Costa Rica’s most popular beach towns, Tamarindo has a lot to offer visitors looking for a short vacation. From surfing, snorkeling, deep sea fishing, and sunset catamaran tours to turtle excursions, there are plenty of activities in the area.
A 3km stretch of white sand with warm blue water, exquisite nature and stunning sunsets, Tamarindo Beach is a dream for those looking to unwind and soak up some sun. This picture-perfect location also provides a great backdrop for couples to enjoy a romantic dinner while watching the sun go down on the beach.
If you’re interested in animal conservation, the Monkey Park Foundation is a great way to spend a day learning about how these animals are protected and helping to keep Costa Rica wildlife thriving. This non-profit is a great place to visit on a day trip from Tamarindo and helps to keep Costa Rica’s most endangered species in the wild.
If you’re looking for more adventure, take a short drive to Las Baulas National Park, which is home to mangroves and a variety of wildlife including howler monkeys. Or try a horseback, zip line, or river boat tour from the many operators nearby.
Located in the north of Guanacaste, Islas Murcielagos are considered to be one of the best places in the world for diving. Their location in the Ocean Pacific and their proximity to the Santa Rosa National Park make them an incredible scuba site where you can see Bull Sharks, Manta Rays and a variety of other species.
A trip to Islas Murcielagos is a must-do for any scuba fanatic. The visibility is excellent, the marine life is abundant and there are many dive sites that will leave you wishing you were underwater more often.
Another reason why Islas Murcielagos should be on your bucket list is the opportunity to see a wide variety of sharks, including Hammerhead Sharks, Tiger Sharks and Bull Sharks. It’s also home to a lot of eels and other species that will leave you in awe!
You’ll also be able to enjoy the beautiful beaches that make this place so famous. The best way to experience Islas Murcielagos, however, is by boat. There are tours that depart from Playa Herradura and Playa Conchal.
San José is a bustling metropolis full of interesting places, faces, and colors. With a population of more than half a million, it is a city that rewards explorers with lively markets, must-see museums, and unforgettable volcanos close by.
A thriving culinary scene is also a must here. Whether you’re looking to sample modern coffee culture at cafes like Cabra Negra, the open-air Franco, or Nueve Specialty Coffee or are after a beer-focused addition to a country that mainly drinks Imperial, Pilsen, or Bavaria brands, there’s something here for everyone.
Costa Rica’s capital is a major hub for travelers and has world-class museums, parks, hotels, theaters, and historic buildings spread throughout the Central Valley. It’s also a great base for adventures into surrounding mountains and volcanoes or exploring the famed coffee country that makes Costa Rica famous.
One of the top day trips from San Jose is the Poas Volcano National Park & La Paz Waterfall Gardens, which is home to 100 rescued species of animals and houses some of the most spectacular waterfalls in Costa Rica. On a clear day, you can see both the Atlantic and Pacific coasts from the top of the volcano.
If you are looking for a place to get away from it all, Cahuita is the perfect destination. This quaint village is nestled among tropical rainforests and wildlife refuges. It also offers postcard-perfect beaches and one of the most impressive national parks in Costa Rica.
The best way to explore Cahuita is by taking a tour. You can book a guided trip that includes transportation, snacks and drinks, and a nature walk in the park.
You can also choose to visit the Jaguar Rescue Center, which is a sanctuary for rescued animals in the region. Here, you can see gorgeous jaguars and other wildlife rescued from the wild or natural disasters.
Another great option is to go horseback riding on a local ranch. You can enjoy the beautiful scenery and feel the wind blowing as you ride through the countryside.
8.Chirripo National Park.
Nestled along the heart of Costa Rica’s Talamanca Mountains, Chirripo National Park offers one of the most challenging hiking experiences in the country. The park’s highest peak, Cerro Chirripo at 12,533 feet (3,820 meters), offers sweeping 360-degree views of the surrounding mountains and valleys.
This 123,923-acre (50,150-hectare) park is home to various sculpted glacial formations such as U-shaped valleys, lakes and terraces. It also has numerous natural viewpoints.
Hikers can choose from a variety of trails in this national park, with most gaining altitude and allowing hikers to see the vast landscape of the area. Some of the most popular hikes include those that lead to Cerro Ventisqueros, Costa Rica’s second-highest peak at 12,507 feet; Los Crestones, a collection of rock spires that jut out of the ridge above the base camp; and a route to the summit of Chirripo.
Before you start your hike, it is recommended to make a reservation with the park’s office in San Gerardo de Rivas. This will ensure that you are allowed to enter the park and avoid long lines on your day of arrival.

domain: geography


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Apr 4, 2011; Houston, TX, USA; Butler Bulldogs forward Matt Howard (54) walks off the court after the championship game of the Final Four of the 2011 NCAA men’s college basketball tournament against the Connecticut Huskies at Reliant Stadium. Connecticut won 53-41. Mandatory Credit: Bob Donnan-USA TODAY Sports
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McConnell dropped Williams with a slow, innocuous hesi-dribble.
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Days after announcing his retirement in the form of a poem, “Dear Basketball,” Kobe Bryant laced up to play his final (…)
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Allegedly, President Mohamed Ould Abdel Aziz got bored and ended the Super Cup final early.
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Taking money away from star players would only give more of it to billionaire owners.
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Happy Rajon Rondo is happy and here to sell you Kings merchandise.


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Taylor and I are addicted to succulents. Our tiny porch hardly has room to sit anymore. Some of our interesting little plants have grown into legitimate monsters. Look at the growth in our “cactus farm” from April to September:
This wall is an old pallet we stole and turned into a vertical farm. The plants really seemed to like this one! Check out the burro’s tail about halfway up. The sempervivums on the bottom two rows went from dead to taking over. And the four potted plants are officially out of control.
These two stumps were plants that got to tall and we had to behead. However, we kept the stumps and new rosettes sprouted. After four months, they’ve pretty much fully recovered.
More comparisons after the jump!
There are three varieties of sedum in this planter, plus some leafy bulb things we tried to rescue in April. The rescue worked – they are devouring everything else.
We built this planter from some of our original succulents (the tall green and the blue in front). But the purple grapetopetalums (also original) are doing the best here! It’s amazing what a summer outside does for some house plants.
We didn’t have as much success on this wall. Another repurposed pallet, it was difficult to keep watered, even for succulents. Well, all except the top row. Holy. Shit. On the left, the tall echeveria is so big it can’t hold it’s own weight. For reference, it’s currently a bit bigger than my head. Also, the mother of thousands (center-right) may literally have 1,000 new plants growing on its leaves.
Basically it’s been a hot, wet summer.
We got some help from Succulents Simplified, especially on identifying different varieties, propagating, pest control, and seasonal care.
Now we just have to figure out how to get it all inside for the winter.

domain: agronomy


Eric Anders and Mark O’Bitz are a prolific indie folk/americana duo who have produced some of the most interesting and beautiful work the genre has seen in the past four years. With the harmonizing talent of Fleet Foxes and the like, but the post-punk core of Tom Waits, these two artists are well known to those of us at YEDM who follow such circles, but we never thought they would end up on YEDM would be seen. We should never underestimate the innovation of a good artist, and the newly remixed versions of their haunting 2020 album American Bardo feature Anders and O’Bitz as the latest artists to prove the point.
Now that we’re hearing them, American Bardo’s remixes, renamed Bardo Hauntings for the occasion and split in two, sound like they were done electronically all along. So much so that the original songs almost sound a bit minimal now. Quite often with folk and Americana works that have been rewritten or remixed into electronica or pop, there’s a moment of “hmm, that’s weird” in your head, followed by a yes or no vote. That’s not the case at all with Bardo Hauntings, and the reason these remixes turn out so well is definitely due to remixers Mike Butler and Steven Jess Borth II (CHLLNGR).
Bardo Hauntings I, The Butler Hauntings contains remixes of half of American Bardo created by recording engineer and producer Mike Butler. Aside from his engineering accomplishments on Phoebe Bridgers, Norah Jones, The Shins, and The Predenders (among countless others), Butler has long worked with Anders and O’Bitz. Thorough knowledge of an artist’s work certainly helps with a project like this, and Butler probably has the best knowledge of those artists besides the artists themselves. He self-produced and mixed American Bardo, along with every Anders/O’Bitz release since then, with the exception of 2021’s True September Songs, including the Bardo Hauntings EPs.
For EDM fans who are also familiar with the world of jazz, folk and ska, Steve Borth should already be a household name. Part of a musical dynasty started by his father, Steven Jess Borth I, Borth II had an early talent for music and was recognized as a saxophone prodigy by the age of 10. Borth has utilized his multi-instrumental talents in ensembles and ska bands around the world, but EDMers may know him better for his ska/reggae/soul/electronica crossover project CHLLLNGR. Fusing all of these genres with breaks, future bass, dubstep, house and techno, Borth’s CHLLLNGR project garnered quite a bit of attention in the EDM world in the early 2010s. His aptitude for such merging also made him the perfect choice for bardo hauntings.
The 12 remixes on American Bardo are split evenly between Butler and Borth to do the two Bardo Hauntings, but it seems the two artists picked whichever they wanted as the track order doesn’t follow the original LP. That way, each producer could tell their own story with the tracks they chose. Apparently Anders and O’Bitz gave them carte blanche.
The title “Bardo Hauntings” is based on the idea that remixes haunt the original songs. In this case, the original songs are American Bardo’s, so these remixes are “bardo spook”. As with ghosts, the original is present and absent at the same time
Butler flexed some compositional muscles that few other than his laundry list of famous clients have heard before. From the startling yet emotional industrial/ambient mix of the “Won’t Live It Down” remix to the heady, theatrical and largely analog remix of “Matterbloomlight” (btw this is now a third version of this achingly beautiful song) . ) to the minimal-hour mix of “Holding Will,” Butler incorporates a range of styles and genres without overdoing it. This is the key to such a fine sonic palette as in the original Anders and O’Bitz discography.
Borth’s remixes are both more down-to-earth and gushing than Butler’s approach. In most of the tracks he remixes, Borth keeps almost all of the original stems, including the instrumentals and general pop/rock structure, as more and more electronica creeps into the melodies as they and the EP progress. The first track “Haunting Abraham”, for example, starts out almost entirely acoustic and then grows in production complexity until Borth adds a subtly analog masked house beat. In the end, the track has a full complement of strings and cannot easily be identified as a pop or folk EDM track. Talk about delicate handling; It’s almost like we’re fooled into rave tracks on Borth’s EP, and each track is a surprise in how it’s going to unfold.
Butler and Borth had very different approaches to this remix project, but they both brought out the best of Anders and O’Bitz’s work and hopefully brought it to a whole new circle of fans. The idea that these are American Bardo electronic “hauntings” is brilliant, as The Bardo Hauntings not only harks back to the original album, but also to George Saunders’ 2017 Pulitzer-winning book, Lincoln In the Bardo based on the American Bardo. It’s an example of how great art makes great art and makes great art, and it can spread across media, generations, and genres. Now all that remains is to take full advantage of Bardo’s creation and let Butler and Borth remix each other’s remixes. In the meantime, a beautiful complete work is here for folk, literature, and EDM fans to enjoy The Hauntings.
Bardo Hauntings I and II are both available now and available to stream on Spotify or buy on Bandcamp. Check the links in this article to learn more about Mike Butler and Stebe Borth II (CHLLNGR).


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Previous studies have shown that alterations in the mechanical properties of cells may be associated with the onset and progression of some forms of pathology. In this paper, an experimental study of two types of cells, renal (cancer) and bladder (cancer) cells, is described which used acoustic radiation force (ARF) generated by a high-frequency ultrasound focusing transducer and performed on the operating platform of an inverted light microscope. Comparing images of cancer cells with those of normal cells of the same kind, we find that the cancer cells are more prone to deform than normal cells of the same kind under the same ARF. In addition, cancer cells with higher malignancy are more deformable than those with lower malignancy. This means that the deformability of cells may be used to distinguish diseased cells from normal ones, and more aggressive cells from less aggressive ones, which may provide a more rapid and accurate method for clinical diagnosis of urological disease in the future.
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Ashkin A, Dziedzic JM, Bjorkholm JE (1986) Observation of a single-beam gradient force optical trap for dielectric particles. Opt Lett 11: 288–290. https://doi.org/10.1364/OL.11.000288
Bausch AR, Moller W, Sackmann E (1999) Measurement of local viscoelasticity and forces in living cells by magnetic tweezers. Biophys J 76:573–579. https://doi.org/10.1016/S0006-3495(99)77225-5
Binnig G, Quate CF, Gerber C (1986) Atomic force microscope. Phys Rev Lett 56: 930–933. https://doi.org/10.1002/9780471729259.mc02c02s8
Brodaczewska KK, Szczylik C, Fiedorowicz M, Porta C, Czarneck AM (2016) Choosing the right cell line for renal cell cancer research. Mol Cancer 15(83):1–15. https://doi.org/10.1186/s12943-016-0565-8
Chahine NO, Blanchette C, Thomas CB (2013) Effect of age and cytoskeletal elements on the indentation-dependent mechanical properties of chondrocytes. PLoS ONE 8(E61651):1–14. https://doi.org/10.1371/journal.pone.0061651
Chen JB, Zhang M, Zhang XL (2018) Glucocorticoid-inducible kinase 2 promotes bladder cancer cell proliferation, migration and invasion by enhancing beta-catenin/c-myc signaling pathway. J Cancer 9: 774–4782. https://doi.org/10.7150/jca.25811
Dao M, Lim CT (2013) Mechanics of the human red blood cell deformed by optical tweezers. J Mech Phys Solinds 51:2259–2280. https://doi.org/10.1016/j.jmps.2003.09.019
Darling EM, Zauscher S, Guilak F (2006) Viscoelastic properties of zonal articular chondrocytes measured by atomic force microscopy. Osteoarthr Cartil 14:571–579. https://doi.org/10.1016/j.joca.2005.12.003
Drury JL, Dembo M (1999) Hydrodynamics of micropipette aspiration. Biophys J 76:110–128. https://doi.org/10.1016/S0006-3495(99)77183-3
Evans EA (1973) A new material concept for the red cell membrane. Biophys J 13:926–940. https://doi.org/10.1016/S0006-3495(73)86035-7
Evans EA, Hochmuth RM (1976) Membrane viscoelasticity. Biophys J 16:1–11. https://doi.org/10.1016/S0006-3495(76)85658-5
Henon S (1999) A new determination of the shear modulus of the human erythrocyte membrane using optical tweezers. Biophys J 76:1145–1151. https://doi.org/10.1016/S0006-3495(99)77279-6
Hochmuth RM (2000) Micropipette aspiration of living cells. J Biomech 33:15–22. https://doi.org/10.1016/S0021-9290(99)00175-X
Horimizu M, Kawase T, Tanaka T (2013) Biomechanical evaluation by AFM of cultured human cell-multilayered periosteal sheets. Micron 48:1–10. https://doi.org/10.1016/j.micron.2013.02.001
Hu S, Tan Y, Sun D (2013) Cell Manipulation with Robot-Aided Optical Tweezers Technology. In: Guo Y. (eds) Selected Topics in Micro/Nano-robotics for Biomedical Applications. Springer, New York, NY, pp 159–174. https://doi.org/10.1007/978-1-4419-8411-1_9
Hwang JY, Lee C, Lam KH (2014) Cell Membrane Deformation Induced by a Fibronectin-Coated Polystyrene Microbead in a 200-MHz Acoustic Trap. IEEE Trans Ultrason. Ferroelectr Freq Control 61: 399–406. https://doi.org/10.1109/TUFFC.2014.2925
Hwang JY, Kim J, Park JM (2016) Cell Deformation by single-beam acoustic trapping: a promising tool for measurements of cell mechanics. Sci Rep 6(27238):1–8. https://doi.org/10.1038/srep27238
Jauffred L, Callisen TH, Oddershede LB (2007) Visco-elastic membrane tethers extracted from Escherichia coli by optical tweezers. Biophys J 93:4068–4075. https://doi.org/10.1529/biophysj.107.103861
Kim H (2003) Quantification of cell adhesion force with AFM: distribution of vitronectin receptors on a living MC3T3-EI cell. Ultramicroscopy 97:359–363. https://doi.org/10.1016/s0304-3991(03)00061-5
Lam KH, Li Y, Li Y, Lim HG, Zhou Q, Shung KK (2016) Multifunctional single beam acoustic tweezer for noninvasive cell/organism manipulation and tissue imaging. Sci Rep 6:37554. https://doi.org/10.1038/srep37554
Lekka M, Laidler P, Gil D, Lekki J, Stachura Z, Hrynkiewicz AZ (1999) Elasticity of normal and cancerous human bladder cells studied by scanning force microscopy. Eur Biophys J 28:312–316. https://doi.org/10.1007/s002490050213
Li QS, Lee GYH, Ong CN, Lim CT (2008) AFM indentation study of breast cancer cells. Biochem Bioph Res Co 374:609–613. https://doi.org/10.1016/j.bbrc.2008.07.078
Lim CT, Dao M, Suresh S (2004) Large deformation of living cells using laser traps. Acta Mater 52:1837–1845. https://doi.org/10.1016/j.actamat.2003.12.028
Lim CT, Zhou EH, Li A (2006) Experimental techniques for single cell and single molecule biomechanics. Mat Sci Eng C 26:1278–1288. https://doi.org/10.1016/j.msec.2005.08.022
Liu HC, Gang EJ, Kim HN, Lim HG, Jung H, Chen R, Kim YM (2018) Characterizing deformability of drug resistant patient-derived acute lymphoblastic leukemia (ALL) cells using acoustic tweezers. Sci Rep 8(15708):1–10. https://doi.org/10.1038/s41598-018-34024-3
Puig-de-Morales-Marinkovic M, Turner KT, Butler JP (2007) Viscoelasticity of the human red blood cells. Am J Physiol-Cell Ph 293: C597-C605. https://doi.org/10.1152/ajpcell.00562.2006
Siegel RL, Miller KD, Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66:7–30. https://doi.org/10.3322/caac.21332
Sleep J (1999) Elasticity of the red cell membrance and its relation to hemolytic disorders: an optical tweezers study. Biophys J 77:3085–3095. https://doi.org/10.1016/S0006-3495(99)77139-0
Sundvik M, Nieminen HJ, Salmi A, Panula P, Hæggström E (2015) Effects of acoustic levitation on the development of zebrafish, Danio rerio, embryos. Sci Rep 5:13596. https://doi.org/10.1038/srep13596
Tan Y, Sun D (2010) Mechanical characterization of human red blood cells under different osmotic conditions by robotic manipulation with optical tweezers. IEEE Trans Biomed Eng 57:1816–1825. https://doi.org/10.1109/TBME.2010.2042448
Tan SCM, Pan WX, Ma G (2008) Viscoelastic behavior of human mesenchymal stem cells. BMC Cell Biol 9:40–46. https://doi.org/10.1186/1471-2121-9-40
Tan Y, Sun D, Huang W (2010) Characterizing mechanical properties of biological cells by microinjection. IEEE T Nanobiosci 9:171–180. https://doi.org/10.1109/TNB.2010.2050598
Tan Y, Sun D, Cheng SH, Han S, Li RA (2011) Robotic cell manipulation with optical tweezers for biomechanical characterization. IEEE Int Conf Robot Autom. https://doi.org/10.1109/ICRA.2011.5979577
Titushkin L, Cho M (2006) Distinct membrane mechanical properties of human mesenchymal stem cells determined using laser optical tweezers. Biophys J 90:2582–2591. https://doi.org/10.1529/biophysj.105.073775
Trickey WR, Lee GM, Guilak F (2000) Viscoelastic properties of chondrocytes from normal and osteoarthritic human cartilage. J Orthop Res 18:891–898. https://doi.org/10.1002/jor.1100180607
Wang N, Ingber DE (1995) Probing transmembrane mechanical coupling and cytomechanics using magnetic twisting cytometry. Biochem cell Biol 73:327–335. https://doi.org/10.1139/o95-041
Williams RD, Elliott AY, Stein N, Fraley EE (1976) In vitro cultivation of human renal cell cancer. I Establishment of Cell in Culture. Vitro 12:623–627. https://doi.org/10.1007/bf02797460
Zhang X, Chen A (2004) Atomic force microscopy measurement of leukocyte-endothelial interaction. Am J Physiol-Heart C 286:H359–H367. https://doi.org/10.1152/ajpheart.00491.2003
Zhong J, Chen Y, Liao X (2016) Testis expressed 19 is a novel cancer-testis antigen expressed in bladder cancer. Tumor Biol 37:7757–7765. https://doi.org/10.1007/s13277-015-4567-8
This work was supported by National key R & D program (No. 2016YFF0203000), State Key Program of National Natural Science of China (No. 11834008), the National Natural Science Foundation of China (No. 11774167), State Key Laboratory of Acoustics, Chinese Academy of Science (No. SKLA201809), Key Laboratory of Underwater Acoustic Environment, Chinese Academy of Sciences (No. SSHJ-KFKT-1701), and AQSIQ technology R&D program (No. 2017QK125).
Conflicts of interest
The authors declare that they have no conflicts of interest.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Wang, H., Qiao, Y., Liu, J. et al. Experimental study of the difference in deformation between normal and pathological, renal and bladder, cells induced by acoustic radiation force. Eur Biophys J (2020). https://doi.org/10.1007/s00249-020-01422-3
- Acoustic radiation force
- Deformability of cells
- Ultrasound focusing transducer
- Renal cells
- Bladder cells


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Note: If you have more than two planets in a sign or house then perhaps reading the Venus for that would be more accurate as well as the actual placement.
Venus is so important in your chart, I really can’t stress this enough. What is Venus in your chart? You probably think about Venus as being the planet of love, beauty and money- and you are right. But in human development Venus is a little more than that. When you are born you are born as your Sun sign- you ego, your father and your true self. Your Moon is your home and mother, your nurturing and your emotional learning in childhood. Mercury is our skill set in later years- when you learn to speak and make connections with others that are called friendships. All this is your base- what made you who you are very early in life. Venus is the love you are able to give and receive based on all the other experiences and connections you have had- because Venus rules your values and they developed as a result of the nurturing from parents ,friends ,brothers sisters and the community and country at large. There are only 12 signs for your Venus to reside, so what makes your Venus your own is so much more: The house and the aspects and the whole chart have to be taken into consideration. Nevertheless, here is a simple but true break down of Venus placements according to what makes you feel good and what can help you when you don’t feel love.
Venus in Aries: Love needs to be open, based on honesty and without heavy restrictions. Your learned to give others affection and physical connection without limits. You are very warm and giving without thought and because of that you expect others to give the same in return. They may have called you selfish for wanting to get your own way, never realizing you are more than happy to return affection in return. Like a child you play with fire and you get burned, so you must learn that not everyone is worthy of you. You grow up and develop pride that hides behind it the hurt and burns of your past. To heal you must let go and open tis flood of passion to the world- your will suffer less being able to be yourself.
Venus in Taurus: Your love needs to be real, something that cannot be taken away from you. Empty promises force you to turn cold to others. You are fully capable of loving yourself as you are in the flesh- misgivings, shortcomings and sensual cravings. You can offer the same gift to others- not unconditional love but accepting love. You learned that your touch is healing magic, that friends run to you for sweet comfort and that the simple things in life can save a heart from breaking. You give your body and only then your soul and when you don you don’t know how to take it back. If you are forced to take your broken heart from another- you will feel empty and in return would try to fill up the space with sensual comfort. But yours is a loving nature and living without expressing it isn’t worth it at all for you true values are based on love.
Venus in Gemini: Your love is learned through mirroring others, if they were good mirrors in childhood then you would be the easy- going of them all, and if not then you will choose to go it alone. In fact, you are easy going either way- just not happy. Your true need is that of a partner in crime, always someone to be there for you. That someone can be of any age, race or gender but they must treat you with acceptance. Through them you will learn your gifts of fun and self-expression, until you are older. When you are older this need would turn into a passion and secret quest: to find your soulmate. At heart you are a romantic, and your soulmate is always right around the corner. To be happy you should not make promises you can’t keep. Don’t love those who ask that of you for that would be your defeat. Instead, live day by day, inventing your soulmate in your dreams and finding pieces of this ideal friend in your reality.
Venus in Cancer: Your love is endless; you have the true ability to lose yourself in the emotion of love. You only knew this type of love towards either in childhood or before you were born and either way it’s not a very secure knowing. Therefore, you feel secure in your emotions only when you give them to others- you can trust yourself but not others. Learning to receive caring and nurture from others is your early task. You may shy away from it in many ways, in private you wonder why love like yours cannot be found. It can be of course. but only if you learn that you are strong. Stronger than others for you love is endless and can survive anything. In early adulthood you masked your emotions in order to get by perhaps by staying a child and not growing up, perhaps by growing up too fast. Your fear is all that is stopping you and once you let go- your ability to give and receive love is beyond compare.
Venus in Leo: Love is for those who are worth it, is what you have learned. One must win love before they have any entitlement for it. And so you made sure as a child that you are worth it, that you are the best- and only then were you allowed to enjoy others affection. For you love is always conditional and dangerous. Being loved unconditionally by someone who doesn’t recognize your worth, is the outmost of failures- you rather have no love at all. And so you develop your own fantasy: where someone wins your heart. They must slay the dragon and kill the witch, and of course you are the prize. When this does not happen, you are secretly sure this is your fault- that you are not good enough. If you only open your eyes you will see how everyone in your path is more than ready to slay the dragon- they just think they are not good enough for you. Love is drama and song for you. Your greatest gift is turning the grayest of stories into a fairytale- by making anyone feel like they are the best.
Venus in Virgo: You don’t need much, just a little of that one very particular something, right? When you were young affection wasn’t given easily. Not that you weren’t loved but circumstances may have required various rules and limits on that affection. As you grew up you developed you system of right and wrong times to express love- probably as a reaction to you upbringing and sometimes in an opposite direction. If affection was cold, you may have no boundaries at all and if you were smothered then you set strict lines in your relationships. As a result you allow yourself to express love through service or in a situation that has its own rules of the game: working relations, marriage and yes even affairs that have their own rules, don’t they? For you to find true love and be happy you must respect your partner and the values they hold and you must know they need you. You may fall into the trap of analyzing until all emotion is gone- for you must know it is the right time for you to open your heart and how will you know this if not through the mind? But nevertheless you will keep to the rules, loyally giving more and more- even if no respect or love is received. For you to be happy you must make your number one rule that of receiving it in return.
Venus in Libra: Love is about harmony. For you it is the space where balance is reached and conclusions stay in place. You are always in two places at once, trying to decide what road to choose next. Your heart loves everyone without reserve and yet you realize early on that this state of affairs isn’t ok with other people. They ask you to choose; maybe it was your family maybe just life. You had to make a choice you could not make and so you never did. You grew up, and made the easy choice- love what is beautiful for beautiful is always good. Beauty was the answer for the unbalance between mind, body and heart. Your hate of conflict meant you would seek where you belong- that group that would not require you to make difficult choices and that would be easily affectionate towards you. As you grow up, this isn’t going to be enough. You will seek partners that challenge you, forcing you to develop a strong sense of individual identity. When that happens, you will find a partner in the true sense of the word. Someone who is amazing, who will join you according to your beliefs and goals in life, maybe an intellectual kind of love? For the best analogy for you kind is that ancient Greek idea where from physical love you learn to know the spiritual kind.
Venus in Scorpio: Your love isn’t open for all to see, only for the privileged. When very young you were much protected, some sad truth was concealed from you. You learned that nothing is as it seems- including love. Being the way you are you promised yourself to protect others from the frightening emotions that you have, emotions born from the disclosure of the difficult truth, that same one that was concealed from you by your caregivers. Love in your heart wasn’t something you could express and so you let it grow within, becoming deeper and deeper- more complicated as the years went by.
By the time you grew up all you knew was that it wasn’t simple for you to become involved with people. Nevertheless you wanted to protect and fight for them, your early romantic involvement may have been with someone weaker or in need of your help. That someone may not have been able to let you have your own weak spots and so it ended. You perceived this as betrayal and closed off your brave heart. You came into your power, not much later and learned that sex is your tool for expressing the depth, the void the need. And yet you wanted something pure and true, something that is based on deep trust that needs not words. Secret affaires are just a mockery of that, but it takes time to figure out. I you do figure it out- yours if the kind of love where one is ready to die for the other.

domain: psychology


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Monte Video (aka Murray Grindley) ex member of The Underdogs, was made commercially famous for his 1982 number two catchy single mouthful, "Shoop Shoop Diddy Wop Cumma Cumma Wang Dang", which made it to number 2 in NZ and also made it to number 11 on the Australian national charts the same year. The song was later re-released in 1983 in the UK on Geffen Records. Later in 1983 he released the single, "Who’s calling?" backed with "All Night Long" and the ultra catchy Egyptian love single "Sheba (She Sha Shoo)"
The album hit the charts late 1983 simply titled "Monte Video" and was recorded at Auckland's Mandrill Studios, mixed in Sydney Australia and released by Mushroom Records and had the previously distributed tracks plus three others, "Hypnosis" and "You Can’t Stop Me Now”. Murray Grindley joined the legendary Underdogs in 1966 and stayed there until around 1972. Here to download is the mini LP "Monte Video" (GHSP-4015). As an added bonus we have put the B side of "Shoop Shoop" 'Don't Mention My Name" (MX60134) which was not on the mini LP.


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I was scrolling through all of the terrific Choir! Choir! Choir! offerings the other night (seriously, their work is so good!) and stumbled across this heartbreaking rendition of Daniel Johnston's True Love Will Find You In the End, which I had to share. It was recorded on September 22, 2019, shortly after Johnston's death, as a tribute to his truly remarkable life. Choir! Choir! Choir! explains:
Daniel Johnston died last week at 58 years old, a singular voice in music and art that inspired so many. Famous acts covered his songs, art dealers sold his paintings, and fans were drawn to his raw sincerity. We were lucky to have him for the time that we did. But his legacy will live on. This past Tuesday, we dedicated our night to him, with proceeds going to Art With Impact, a charity that uses art to help people working through mental illness. Rest In Peace, Daniel Johnston.
If you want to hear some more of Johnston's work, check out this great Tiny Desk Concert from June, 2012. NPR Music describes the artist and the set, which includes "Mean Girls Give Pleasure," "Hold on Mama," and "American Dream":
A troubled soul with a talent for writing honest, disarmingly direct songs, Johnston performs in the NPR Music offices. His short set closes with one of his classics: "True Love Will Find You in the End."


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Upper Playground announced yesterday that they, in association with ASTRO Gaming, would soon be launching the Artist Series Speaker Tags for A40 audio system. The three-piece gaming headset collection will feature interchangeable tags by Sam Flores and Munk One alongside the original Upper Playground ‘Walrus’ logo. The Upper Playground Artist Series Speaker Tags are available as part of the Upper Playground Edition A40 Audio Systems and standalone Speaker Tag sets in limited quantities sold exclusively online at www.astrogaming.com.
If you head over to www.upperplayground.com right now, you stand a chance to score this dope audio system, complete with all three tags, for free. Do it!

domain: entertainment


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Mental Health Advocate Answers the Call to Public Service
Dr. Leanne McBurney Truehart has built her career on caring for the mentally ill in the community. In addition to the over 20 years as a practicing psychiatrist and serving on mental health boards and organizations, Dr. Truehart also serves as deputy coroner, handling over 2,600 psychiatric commitments in St. Tammany Parish over the last two years.
The increasing numbers of homicides, suicides and fatal accidents has raised awareness of the role that coroners play in death investigations and autopsies. However, in the state of Louisiana, involuntary psychiatric commitments are a huge part of coroners’ responsibilities. In fact, commitments in St. Tammany occur at a proportionally higher rate than death investigations.
Access to adequate treatment and service has always been a concern. Yet, the problem has been exacerbated in the aftermath of Hurricane Katrina. It has become extremely difficult for people to get the mental health services they need quickly and appropriately—regardless of insurance coverage or ability to pay.
As Mental Health Director at the St. Tammany Coroner’s Office, Dr. Truehart has gone beyond the act of psychiatric commitments. She has worked to address the issues and challenges the mentally ill face on a daily basis. In fact, providing access to quality mental heath care is one of her greatest passions.
“One of the first things we need to do, is to remove the stigma surrounding mental illness,” she said. “Most everyone in the community knows someone, or has been impacted by someone with a mental illness. We need to look for opportunities to treat not just the patients, but to provide help for families and loved ones as well.”
According to Dr. Truehart, when mental illness is left undiagnosed or untreated, the consequences can be far reaching. Impacts range from drug and alcohol abuse, family dysfunction, unemployment, violence and suicide.
“For me, performing involuntary psychiatric commitments is more than a job requirement, it is part of a much larger societal issue. It is only one step in a very long, arduous process of recovery,” she said. “When we work in partnership with health professionals in our community, we can improve the chances for recovery tremendously.”
Dr. Truehart is involved with the Behavioral Task Force set up by
Parish President Pat Brister to address mental health issues in St. Tammany and the Northshore. The group consists of representatives from the Coroner’s Office, 22nd Judicial District Court, Florida Parishes Human Services Authority, and other notable agencies and organizations that have a vested interest in improving access to quality mental health care in St.Tammany. Together with important work she does for non-profit groups such as NAMI (National Alliance on Mental Illness) and STOPS (St. Tammany Outreach for the Prevention of Suicide (STOPS), Dr. Truehart welcomes the busy schedule because she knows that real lives are being helped. “I am fortunate to work with extremely dedicated agencies and colleagues. Together we have reached a pivotal point where we are raising awareness about mental illness and suicide prevention, especially among the young people in our community,” she said.
Dr. Truehart will be the first to tell you that the position as Mental Health Director is a dream job for her. It encompasses her professional goals, her leadership skills and her passion for bringing mental health resources to the community. So why is this wife and mother walking away from her dream job to run for the position of St. Tammany Coroner?
“I never thought I would be running for office,” she said. “But there was no one I knew or trusted to step up to the plate. Being in the Coroner’s Office, and being a concerned citizen, I know what is at stake. I am in a position to restore public trust—to bring professionalism, quality and transparency to the position.”
Noting that death investigations are also an important part of the Coroner’s Office, Dr. Truehart said she is committed to utilizing the best investigative practices to assist the law enforcement professionals in St. Tammany. To that end, in addition, communications and cooperation with the Sheriff’s Office are also a priority.
“My dad, who is one of the smartest people I know, is convinced that the vast majority of the world’s problems are from miscommunication,” she said. “I understand how vital it is that there is a clear and open line of communication and can use my leadership skills and psychiatric training to help make that happen.”
Because of her work in the judicial system and with law enforcement, Dr. Truehart said she has a unique perspective on the collaborative roles the offices play. “Just as we work together with regard to mental health issues, we need to work together with death investigations.”
While her experience, training and unique perspective are a perfect fit for the Coroner’s Office, Dr. Truehart admits the decision to run was not an easy one. She and her husband, David, an international airline pilot, made the decision together after “long conversations and prayerful consideration.” Because of his flight schedule, the couple wanted to maintain a sense of normalcy for their eight-year-old son Matthew.
“My mom (well-known Slidell dermatologist Dr. Elizabeth McBurney), was a great role model. Not only did she teach me to be a kind and compassionate physician, she showed me how to successfully manage career and family. Every decision I make is in the best interest of my family,” she said.
I want people to know not just about my qualifications, but about who I am as a person—a person of integrity and honesty, a good mother, wife and friend.
Paid for by Leanne Truehart campaign. For more information visit

domain: sociology


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The drive to become more efficient in a post-GFC-world, has meant developers of technology have made pointed efforts to ensure products they bring to market have tangible return on investments when it comes to operational excellence. Virtualisation would have to be the most obvious example. Consolidation of resources and scale out architectures enabled by virtualisation literally mean the sky is the limit, however, with the roof removed and an increasingly data hungry population of seven billion people across the globe who already account for 45GB each, it is clear information sprawl has changed our world forever.
For those who are employed to manage this new ecosystem, the challenges are equally as vast, but according to the recent report from Enterprise Strategy Group (ESG), the number one data protection challenge is the need to reduce backup and recovery times.
False faith in Tape
In the face of the big data explosion, 55 per cent of organisations are today focused on optimising their hybrid physical/virtual computing environments; the issue being the management of legacy systems, like tape, in concert with newer technologies, like deduplicating appliances. The stress point of course comes from the fact today’s backup teams are simply under-resourced and without the headcount, technology needs to plug the gap. And it is no small gap. This conundrum is wide spread. In spite of faster, more secure disk, many organisations still use tape believing it to be cheaper.
Alarmingly, on average, four backup solutions are used in each organisation for physical systems, while another three are used for virtual. ESG’s 2011 study highlighted the resulting dilemma, reporting 62 per cent of respondents were using separate applications for each operation, each requiring unique policies, management tools and techniques. It is little wonder then that even as virtualisation projects come with so many benefits they are also posing some tough questions to CIOs and administrators when contemplating their best practice integration. In fact more than 80 per cent of respondents to the ESG research study said virtual backup was a top IT challenge.
Virtualised data is still real data
Organisations are quickly realising that agility is the most important characteristic when it comes to IT doing the best by the business, so it’s good to know whether it’s virtual or not, there are some simple steps organisations can take to centralise backup and recovery of both physical and virtual server environments that give them this dexterity.
- Unify Physical and Virtual: A common software platform enables organisations to centrally schedule backup jobs, manage recoveries, monitor the success and failure of backup jobs and provide a common console that backup administrators can use to administer all backup jobs.
- Leverage the Backup Team to Protect VMs: Help keep the virtualisation project humming by engaging the existing storage and backup teams to support your goals. In doing so, the goal of 50 per cent or more virtualisation can be achieved faster.
- Implement automated and centralised monitoring and reporting: The creation of a virtual machine can now occur in as quickly as a few minutes by an individual and their creation can be automated through the use of scripting.
- Choose a platform with deep API integration: Integration with leading virtual server platform features such as the vStorage API in VMware vSphere should be viewed as a prerequisite in order for them to successfully protect and recover these platforms.
- Dedupe Everywhere: Organisations should implement deduplication on all backup data at all levels across the enterprise’s physical and virtual environments.
- Get Granular on Granular Recovery: Granular recovery is where the rubber meets the road when it comes to integration with VMware and Hyper-V. Those that have done it well can recover the single file they want, when they want, without the VM or backup administrator being forced to traverse the directories and files.
By implementing a data protection strategy that provides improved virtualisation visibility, and setting up the right processes, organisations can not only realise the initial benefits that server virtualisation delivers but successfully avoid some of the challenges that can accompany it.
Paul Lancaster is the Director of systems engineering for Symantec's Pacific region.


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Is Alaska still under a tsunami warning?
A Tsunami Warning Has Been Lifted For Parts Of Alaska After An 8.2 Quake. PERRYVILLE, Alaska — A powerful earthquake that struck just off Alaska’s southern coast caused prolonged shaking and prompted tsunami warnings that sent people scrambling for shelters.
What was the most recent tsunami in 2021?
2021 Fukushima earthquake
|UTC time||2021-02-13 14:07:49|
|Tsunami||0.2 m (0.66 ft)|
|Aftershocks||Multiple. The largest is an Mw 6.0.|
|Casualties||1 dead, 186 injured, 16 serious|
When was the last time there was a tsunami in Alaska?
The impact was heard 50 miles (80 km) away, and the sudden displacement of water resulted in a megatsunami that washed out trees to a maximum elevation of 1,720 feet (524 meters) at the entrance of Gilbert Inlet.
1958 Lituya Bay earthquake and megatsunami.
|UTC time||1958-07-10 06:15:58|
|Local date||July 10, 1958|
|Local time||22:15 PST|
Was there a tsunami in 2020?
On 30 October 2020, a significant tsunami triggered by an earthquake of magnitude 7.0 Mw hit the island of Samos (Greece) and the Aegean coast of the Izmir region (Turkey).
Is Hawaii still under tsunami warning?
The Pacific Tsunami Warning Center says after evaluation and based on all available data, there is no tsunami threat to Hawaiʻi.
Will there be any tsunamis in 2021?
The 2021 Los Angeles Mega-Tsunami was the worst natural disaster in the history of the United States. Triggered by a massive unknown underwater volcano near Hawaii, the tsunami was eighty feet in height upon making landfall in southwestern California on April 1, 2021.
What disasters will happen in 2021?
- 2021 North American Wildfire Season. October 19, 2021.
- 2021 Atlantic Hurricane Season. October 5, 2021.
- 2021 Haiti Earthquake and Tropical Storm Grace. …
- 2021 International Wildfires. …
- 2021 North Indian Ocean Cyclone Season. …
- 2021 Winter Storms. …
- 2020 North American Wildfire Season. …
- 2020 Atlantic Hurricane Season.
Did Alaska have an earthquake 2020?
In July 2020, the Aleutian Subduction Zone was the source of an Mw 7.8 earthquake which struck the same region south of the Alaska Peninsula.
|UTC time||2020-10-19 20:54:38|
|Local date||October 20, 2020|
|Depth||28.4 km (17.6 mi)|
Has a mega tsunami ever happened?
– No such event – a mega tsunami – has occurred in either the Atlantic or Pacific oceans in recorded history. NONE. – The colossal collapses of Krakatau or Santorin (the two most similar known happenings) generated catastrophic waves in the immediate area but hazardous waves did not propagate to distant shores.
How far away was the 1964 Alaska earthquake felt?
The earthquake was felt throughout most of mainland Alaska, as far west as Dutch Harbor in the Aleutian Islands some 480 miles away, and at Seattle, Washington, more than 1,200 miles to the southeast of the fault rupture, where the Space Needle swayed perceptibly.