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There are highs and lows in any relationship. Early stages are frequently characterized by solid and ardent feelings that eventually mellow with time. You can begin to worry that your relationship is becoming too stale or even dull as it becomes steadier and more comfortable. However, the distinction between boredom and comfort must always be kept in mind. After all, it’s crucial to feel at ease with your spouse. It considers that you have confidence in them and feel free to be who you are around them.
This article goes through several telltale indicators of a boring relationship and some reasons why the novelty quickly wears off. It also discusses dealing with relationship ennui and determining whether to end a relationship.
Is it normal to get bored in a relationship?
Relationships are no exception to the rule of people feeling bored constantly. However, feeling bored in a relationship may be particularly depressing since it can make you wonder whether you and your partner are compatible enough and have what it takes to have a long-lasting, meaningful relationship. Many couples experience the typical and common problem of becoming bored in their relationships. But that doesn’t imply you should do nothing to help the problem and let it play out naturally. No matter how common or frequent boredom in a relationship may be, it is something to be aware of and work to address.
Relationship boredom may indicate a more significant underlying issue, or it may result in serious relationship problems if left unattended. Because of this, it’s critical to comprehend the causes of your relationship’s dullness and to think about putting strategies into practice to deal with it in a healthy, productive approach.
Why relationships turn into boringness
You and your spouse likely had feelings of joy and a strong desire to spend time together in the early stages of your relationship. But with time, those first sentiments frequently become less intense. Instead of intense passion, your connection grows closer, more trusting, and more intimate. This is a typical indication that your relationship is transitioning from what is referred to as passionate love (which is typically more ephemeral) into what is referred to as compassionate love (which is more enduring).
Numerous factors can make a relationship uninteresting. Finding and identifying the sources of your boredom can help you and your partner have a much better connection. The following are some of the most significant causes for couples to have a time of stagnation:
1. Following the flow
In a partnership, it’s simple to overindulge in comfort, and that’s okay. However, if it results in protracted periods of indifference, it may cause issues. It needs you and your partner to go back to the beginning and recreate some of the activities you enjoyed when you first started dating if you and your partner have hit a rut. One weekly date might be a terrific opportunity for communication and reconnection. Concentrate on the emotions you experienced at the start of your relationship and try to imagine your spouse with a similar eagerness.
Some couples identify activities they enjoy doing together and then do those activities consistently. Occasionally changing things up in relationships can be extremely useful. You must show interest, attention, and affection to keep a relationship engaging. Boredom inevitably results from ignoring needs, avoiding each other’s company, and ignoring feelings.
3. Losing sight of oneself
Some people lose themselves in relationships, which may cause them to lose sight of their own life goals and result in personal boredom that permeates the whole partnership. You must remember that it won’t be long before you get tired of repressing your needs and wants if you’ve given up on your interests, goals, or aspirations in favor of someone else’s.
4. Failing to improve physical intimacy
In relationships, it’s simple for sexual interactions to become a means to an ecstatic end. This may result in an unsatisfying sexual life, only making you feel more bored. But it’s never too late to reconnect with your mate and rekindle the thrill and joy you previously experienced. Even if you find it challenging to accomplish it on your own, you can always seek the support of certified relationship coaches for expert emotional intimacy coaching that can aid you in rekindling connection and interest in your relationship.
5. Disregarding close emotional ties
Physical and emotional intimacy go hand in hand, and a partner’s incapacity or unwillingness to disclose their emotions can frequently lead to stagnation. It is necessary to understand each other’s emotions and support each other mentally. This will enhance your relationship to continue to be a passionate one.
Passionate love is characterized by ecstasy and ardor. It can be a nearly all-consuming kind of love that drives you to spend as much time as possible with the person you’re fascinated with. Everything you discover about them looks novel and exciting as you continue to get to know one another.
6. Having separate hobbies
Lack of shared hobbies can occasionally contribute to partner boredom in relationships. If you aren’t fundamentally compatible, your relationship could get tiresome. Finding common ground to keep you linked to one another can be difficult if your goals and interests differ.
It would help if you also emphasized engaging in interests apart from your relationship. By doing this, you will feel more enthusiastic about your life in general and have a topic of conversation and something to share with your partner.
7. Never getting into disputes
A relationship can suffer significantly from frequent bickering, as well as from complacency and constant caving in. Sharing opposing viewpoints occasionally and allowing yourself and your partner to express various points of view can be helpful.
As a result, to lead a healthy relationship, you need to depend on effective communication. Over time, you can notice that you start to drift away if you aren’t being severe while discussing your intentions, sentiments, opinions, and other matters.
Do couples become tired and bored of one another?
When you look around, it could be simple to see spouses and couples sick of one another and consider it an inevitable part of life. However, the emotional or psychological rule that all couples eventually get tired of one another and that there is nothing you can do about it other than wait for it to happen to you is untrue. The majority of couples do go through challenging times and encounter relationship issues. However, the cause of unpleasant or failing relationships is frequently a failure to act to address the issues that occur.
Therefore, even while relationship ennui may occasionally occur and some couples “grow tired of each other,” it doesn’t necessarily signal that your relationship is over. Many relationship problems call for active participation and not giving up.
However, you must be aware that sometimes getting bored will persist despite your best efforts and those of your companion. You might wish to think about getting expert emotional coaching at these times. Relationship experts can assist you in identifying the root cause of this issue and alter any problematic behavioral habits.
Relationships can get monotonous, particularly if both partners have started to work less complicatedly to appreciate one another and their shared hobbies. But while boredom may not seem like the most significant concern, it can develop into a severe problem. To maintain a healthy relationship, you need to identify the reason for getting bored and improve it.


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A new exhibition has opened at Causeway Hospital showcasing work completed with participants from Mental Health Community Outpatients as part of the Arts Care ‘Here and Now’ Project.
Helene Brynes, artist, facilitated five workshops in the Coleraine area including ‘Dream Hats’ where she worked closely with eight participants from the mental health service along with Occupational Therapist, Alice McKeown and Technical Instructor, Cindy Friers.
The participants made and decorated a hat using a place of their dreams as the inspiration.
The completed hats were given to the participants, but prior to this Helene took photographs of the completed hats and the entire project.
These photographs can be seen in the Causeway Hospital exhibition space of the first floor corridor.
The exhibition was opened last month by Eddie Aiken, the Chair of the Causeway Arts Care Group to the enjoyment of those in attendance who were suitably impressed by the quality of the work.
Arts Care organised the project across the key health and community care services for older people in all of the five Health and Social Care Trusts in Northern Ireland.

domain: news


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Kiran Musunuru, M.D., Ph.D.
This page shows the publications Kiran Musunuru has written about Multifactorial Inheritance.
Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T, Voight BF, Bonnycastle LL, Jackson AU, Crawford G, Surti A, Guiducci C, Burtt NP, Parish S, Clarke R, Zelenika D, Kubalanza KA, Morken MA, Scott LJ, Stringham HM, Galan P, Swift AJ, Kuusisto J, Bergman RN, Sundvall J, Laakso M, Ferrucci L, Scheet P, Sanna S, Uda M, Yang Q, Lunetta KL, Dupuis J, de Bakker PI, O'Donnell CJ, Chambers JC, Kooner JS, Hercberg S, Meneton P, Lakatta EG, Scuteri A, Schlessinger D, Tuomilehto J, Collins FS, Groop L, Altshuler D, Collins R, Lathrop GM, Melander O, Salomaa V, Peltonen L, Orho-Melander M, Ordovas JM, Boehnke M, Abecasis GR, Mohlke KL, Cupples LA. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009 Jan; 41(1):56-65.
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

domain: medical


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The clients for this piece of work had seen a front door glass design in a household paint brochure. They wanted their leaded light to be as close as possible to it. For the colours they were looking for something to compliment an external leaded lantern already hanging at their home.
The final design, seen below is very pleasing. A concentration of colours in the centre, echoing the outside lantern, was complimented by a narrow outer border of colour. The textured, clear glass set in a grid pattern maximised light into the hallway, whilst providing privacy.
Copyright Mel Price 2020
Design rights Mel Price and Armando Magnino 2001-2020
Photographs Mel Price, Armando Magnino

domain: artistic


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The first ever Women of the World (WOW) festival in Dhaka recently ended at the Bangla Academy premises with a concluding ceremony, followed by an energetic concert. Barbara Wickham, OBE, country director of the British Council in Bangladesh, Jude Kelly, Founder of WOW Foundation, Rafiath Rashid Mithila, Head of Early Childhood Development programme in BRAC International, and Captain Afsana Shahin, one of the speakers of WOW Dhaka Rajshahi Chapter, spoke at the concluding ceremony.
The concert put a befitting end to the festival. The theme of the concert, coordinated by Armeen Musa, was a fictional society, run by matriarchy.
The Kathmandu Killers, from Nepal, lifted everyone's mood in the beginning with their punk rock songs.
Armeen's project, The Ghaashphoring Choir, then enchanted the crowd with their fusion-filled renditions of popular Bangla tracks. F Minor, an all-girl band from the hill tracts, singer Sovvota and folk singer Baby Akhter, were equally impressive throughout the entire show. Elita Karim's song Urey Jetey Chai added an inspiring note to the concert, which ended with the choral performance of the theme song, Shurjo, by composed by Tinu Rashid. All of the performers in the wonderful concert got together to sing this uplifting song, which sent a clear message: impossible is nothing for women of the world.
Photo: Monon Muntaka


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Thailand giving whistles to female visitors to Phuket to sound in emergencies
BANGKOK, Thailand — Female tourists visiting the Thai island of Phuket are going to be given whistles to sound in case of an emergency.
The Thai Tourism Ministry announced the move Monday, two days after the murder of a Swedish woman in broad daylight.
The whistles are part of a campaign to increase security on Phuket, one of Thailand's most popular tourist destinations.
The Swedish woman, 27-year-old Hanna Charlotta Backlund, was stabbed to death Saturday while taking a walk on Mai Khao beach, on the northern tip of Phuket.
Her attacker remains at large.
Phuket police Maj. Sathabhorn Sangaunsuk says the whistles will be shaped like the symbol commonly used to designate women - a circle above a cross - and can be worn around the neck.
Meanwhile, the Tourism Ministry also plans to increase the presence of security guards around the island and publish safety manuals that will be distributed to tourists.
Authorities said the security plan has just been devised and they did not know when distribution of the whistles would begin. http://www.freerepublic.com/focus/f-news/1987245/posts


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Reviews and Problems with Yurbuds Ironman Inspire Talk
Showing 1-10 of 31
Excellent earbuds for fitness activities
31 July 2014
Excerpt: I was going to try the version with clips but opted for these. They don't fall out and sound great for cheap earbuds. I have tried a number of different brands and this is the only one that has met my expectations.
Summary: I already had the original Ironman Yurbuds for 3 years and loved them even though they were a little big for my ears. They do not fall out even when running or cycling. I have even accidently yanked on them and they still stay put. I use them everyday. I jumped at the chance to try the smaller version. I love them. I think they sound better than Beats buds and are much more reasonably priced.
The Yurbuds earbuds are the best for staying in your ear while running.
4 April 2014
Summary: I bought these headphones as a backup to my Inspire Duro Yurbuds. Here is a summary of the pros and cons: Pros: 1. The buds, the buds, the buds. Did I say the buds? 2. The music control button. 3. The sound is decent and you can still hear your surroundings. 4. The angled headphone jack. Cons: 1. The cord could be a little longer. 2. Not sure how long the plastic cord will last. The main reason I like these headphones is because of the earbuds.
Excerpt: The ear bugs are not that good and don't stand up to how it was described online and on the package...I wish I saved the box to reurn the item...the buds don't stay in my ear when moving and working out.
Excerpt: I got these because I was tired of having to change headphones every three months due to sweat damage. Well, these headphones claim to be for sports and sweat resistant. They might be, but they sound terrible. I really want to be able to have a clear sound when I am running a couple of miles and these do not do that. They sound like the old airplane headphones we used to get when I was a kid... But hey, at least they are comfortable. Wrong.
Summary: The sound was quite surprising to me to be honest. A lot better than the ones I was using before and any of the other ones I ever have used. I do LOVE and i mean absolutely LOVE how they fit in my ears!! They will not slip out or move even a tiny bit. If you get them in correctly you will not be able to feel them in your ear through the entire time of wearing them. The talk function is pretty great as well. The other person always can hear me pretty quickly.

domain: hobby


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Hexagon gemstone necklace
Hexagon stone necklace
This lovely hexagon gemstone necklace is the perfect way to add a touch of elegance to any outfit and to benefit from the power of stones. The necklace features a beautiful hexagon-shaped stone. This necklace will elevate your spirituality. This necklace would make a great gift for crystal lovers!
Hexagon necklace meaning
The meaning of the hexagon necklace will depend on the person who is wearing it. For some, the hexagon might represent good luck or prosperity. For others, the hexagon might be a reminder of their culture or heritage. No matter what the meaning is, the hexagon necklace is a beautiful piece of jewelry that can be enjoyed by everyone and will bring you all the benefits of natural stones.
- Materials: Natural stone, steel
- Length: 68 cm
- Size: 52*11
- Each stone is unique, the shades of color may vary
- Meticulous finish
Please note that due to COVID-19, our shipping times may have delay depending on your country. Your items will be delivered within:
|Country||AVERAGE DELIVERY TIME|
USA & Canada
Rest of the World
Feel free to reach our team if you have any question: firstname.lastname@example.org
Complete your pendant set and feel the power of natural stones with the Tourmaline necklace. You can also check our Healing crystal necklace, to find the stone you're looking for. Or simply opt for one of our Healing crystal jewelry to complete your collection of healing stone jewelry with many virtues.


As the world of manufacturing is evolving, China OEM CNC turning services have become more and more prevalent. Original Equipment Manufacturers (OEMs) in the Chinese market have made significant strides in improving their computer numerical control (CNC) machining capabilities. In this article, we will discuss the advancements being made by China's OEM CNC turning service providers, the industries they cater to, and the opportunities these services create for businesses.
Innovations in China OEM CNC Turning Services
China's aggressive investment in CNC machining technology, coupled with advancements in automation and CAD/CAM software, has led to the proliferation of CNC turning services:
1. Precision machining:Chinese OEMs have significantly improved their CNC turning capabilities, now offering precision-machined parts that meet or exceed international standards. Industry 4.0 advancements have increased accuracy and precision in manufacturing, thereby ensuring better quality products for customers around the globe.
2. Flexible production and customization:Modern CNC turning centers can handle various materials such as metals, plastics, and composites, increasing flexibility in production. Moreover, these centers are capable of producing an extensive range of customized parts, making it easier for businesses to get precisely what they need.
3. Reduced lead times and costs:With advancements in technology and efficient workflows, China OEM CNC turning service providers can deliver products to customers at reduced lead times. This combination of quality, speed, and cost-effectiveness has made them increasingly competitive in the global market.
4. Environmentally friendly solutions:Another development in China's CNC turning services is a greater emphasis on energy conservation and waste reduction. By focusing on sustainable methods, these service providers have reduced their environmental footprint, making them an attractive choice for businesses concerned with sustainability.
Industries Benefiting from China OEM CNC Turning Services
1. Aerospace:Aircraft components require high precision and accuracy, as well as the ability to withstand extreme stress and fatigue. Manufacturers in the aerospace industry have turned to China OEM CNC turning services for complex parts made of high-performance materials, including titanium and nickel-based alloys.
2. Automotive:The automotive industry heavily relies on CNC turning for manufacturing essential components, such as engine parts, brake systems, and suspension components. Chinese OEMs have been increasingly dominant in this sector, providing car manufacturers worldwide with high-quality, reliable, and affordable parts.
3. Medical devices:High precision and stringent quality standards are essential in the medical device industry. China OEM CNC turning services offer accurate machining for surgical equipment, dental devices, orthopedic implants, and more, meeting the strict requirements of the healthcare sector.
4. Electronics and telecom:China has been the world's largest telecommunications equipment market for years, and the electronics sector is also booming. OEM CNC turning services play a significant role in fabricating intricate components for electronic devices, including smartphones, tablets, and communication devices.
5. Oil and gas:China's CNC turning services have met the demand for robust and high-precision components in the oil and gas sector. Parts such as valve bodies, connectors, pump shafts, and seals, among others, can be efficiently produced in a cost-effective manner, giving the industry a reliable manufacturing partner.
Opportunities in China OEM CNC Turning Services
1. Business Expansion:Companies with custom design and engineering requirements can benefit from partnering with a Chinese OEM CNC turning service partner. These services allow businesses to focus on their core competencies, letting the Chinese OEM handle the complex manufacturing processes.
2. Cost Savings:By leveraging China OEM CNC turning services, companies can get better pricing for high-quality products, ultimately reducing production costs.
3. Scalability:You can get small or high-volume production runs with China OEM CNC turning services, facilitating your ability to scale your business up or down as needed.
4. Improved Efficiency:Incorporating CNC turning services into operations provides faster production cycles and reduced waste, improving efficiency and overall productivity.
5. Greater Access to Technology:By partnering with a Chinese OEM CNC turning service provider, businesses can access state-of-the-art technology without the need for substantial investment in equipment and training. This partnership allows businesses to improve their manufacturing processes by leveraging technology advancements.
In summary, China OEM CNC turning services offer a powerful solution to companies in various sectors, driving innovation and providing significant benefits in cost reduction, efficiency, and product quality. With China's ongoing advancements in CNC machining technology, the potential for growth and collaboration between businesses and China OEM CNC turning service providers is limitless, leading to a bright future for all involved parties.china oem cnc turning service


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Medium Roast Option: Light bodied, with light acidity. Notes of nuttiness.
Dark Roast Option: Full bodied with well balanced acidity and notes of dark chocolate and toasted nuts.
Region: San Miguel, La Paz, Marcala
Farm: Cooperativa RAOS
Certification at Origin: Organic
Altitude: 1200–1700 meters above sea level
Background from our importer:
The Cooperativa ROAS has been a source of our women coffee producer coffees in the past. Currently, we are offering coffee from a variety of farmers from the cooperative.
One of the reasons the Cooperativa RAOS is determined to market its women members' coffee is that 60 percent of the women face gender-based legal issues with regards to the ownership of their land, as well as limitations to the credit they can receive to finance the harvest every year. In addition to the program premiums these women receive for this lot, Cooperativa RAOS has many very active educational support programs open to all members. Gender assemblies are held by female members in order to discuss the women's needs, as well as ways of increasing equity within the group and community.
"Gender equity means that women and men have the right to equal and fair access to the use, control, and benefits from the same goods and services of society, as well as to decision-making in the areas of social, economic, and social life, as well as politics." This is Cooperativa RAOS's mission statement with regards to gender, a philosophy that the organization supports through the development of training farms, as well as integrated farm-management programs, and in increasing access to these programs as well as organic-farming support to all members, including the female growers.
Photos from La Bodega & Cafe Imports

domain: sociology


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Rates & Rentals
Come stay for the day and enjoy our grounds. For those who are looking to stay longer, our campgrounds offer sites to throw a tent on or drive in with an RV. There are sites available with water and electric, as well as sites without for those who want to rough it. Or stay in one of our 8 rental units.
Come join us at Empire Haven and get away from it all. Your worries. Your cares...even your clothes. A relaxed, casual and friendly place where you can spend a lazy afternoon, a laid-back weekend, or as long as you like.
YOUR EVENTS COMMITTEE IS NOW PLANNING FOR THE 2024 SEASON!!!

domain: travel


3 Church Street
Cambridge, MA 02138
History, Lectures & Conferences, Meetup, Social Good
CAMBRIDGE FORUM invites you to join its latest event on Tuesday October 5 at 5 pm ET.
THE TRUTH AT THE HEART OF THE LIE
Hear James Carroll‘s deeply personal exploration of what has broken the modern Catholic Church as chronicled in The Truth At The Heart Of The Lie, the most recent in his canon of books critiquing the blessings and limitations of Catholic Christianity.
A former priest himself, Carroll peers into the shadows of deceit and corruption that have shaken his belief system, unearthing the awful truth hidden in the human failings, sins and betrayals of the Church’s hierarchy of bishops and priests. Carroll contends that the Catholic Church and its clergy are at a critical tipping point. Can it and they yet be saved?
Do you have experiences or opinions to express on this topic? Share info with your friends.
Sign up for this free event on Zoom.
James Carroll is author of 21 books, both fiction and non-fiction. His essays and articles have appeared in The New Yorker, Daedalus, The Daily Beast and other publications. His Boston Globe op-ed column ran for 23 years.


Fred Elser First Sunday Science at the Seaside Center
Year-round. Open on the first Sunday of each month.
Free. Family activities throughout the afternoon and talks by experts in the field. No pass required November - April. Complimentary admission for First Sunday programs May - October. For more information, contact Seaside Center Manager Cynthia Ehlinger at firstname.lastname@example.org
Special Event: June 25 Experience the Sound
Presented by the Greenwich Shellfish Comission in conjunction with the Seaside Center Grand Opening
July 2: Exploring the Long Island Sound from the Bottom
Captain Dennis Habza of SqualusMarine.com will give a video presentation on his expeditions to local shipwrecks, their history, and his underwater adventures. He also will talk about local marine life and the importance of marine environmental awareness. Fun, family activities and marine tank all afternoon.
August 6: All About Algae.
Dr. Craig Schneider, Trinity College, will talk about deep water algae from Bermuda collected by submersible and rebreather diving, and will show some underwater movies as part of the talk. Simona Augyte, PhD candidate will also speak about local algae and help identify local seaweeds specimens. Algae are photosynthetic organisms that come in many sizes and colors, produce more than 71% of the Earth's oxygen, and are used in hundreds of products. Learn why you should know more about them. Make your own seaweed pressing
September 3: Vermicomposting.
Greenwich Conservation Commission and Greenwich Community Gardens will introduce participants to composting with earthworms. Hands-on activities and demonstrations on how to set up a worm bin, which helps turn kitchen scraps into a valuable soil amendment. Learn about earthworm biology and how to care for their habitat. Activities for the entire family. Free vermicompost bins available while supplies last. One per family, Greenwich residents only.
Summer Season: Sunday, June 25 – Monday, September 4, 2017
Tuesday - Sunday, 11:00 am – 5:00 pm
The Seaside Center educates visitors about the ecology of Long Island Sound and features:
- Live-animal marine touch tank open year-round
- Four marine aquaria of local species open seasonally
- Seashore dioramas of summer and winter birds, fish, and other local species, and an underwater oyster reef
- Environmental activities and video presentations
- Helpful naturalists


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Natural Sisal with Winter Plaid Bird Ornament, 43/4", ST2433980_bird
- Mix Match Sale:
- See our Specials Page or Buri Main Page
Sitting on a Branch Plant Bristle Bird Christmas Ornament, 4 3/8 inches. Made of sisal and fabric.
Give this adorable bird decoration to a garden or country decor enthusiast. It is made with a mixture of natural and dyed lighter color tones bristles with other plant and pine cone parts used to create the wings and tail. It is attached to a real twig branch and includes a Dutch shape hat with three pom poms plus a matching bow tie under the chin area. All sides are finely detailed. (New 2018)
Matching items: If still available they will be displayed below under "You may also like".
Also see the links under related categories to view more from our country and bird themed Christmas tree ornaments collections.
* This item will also sit upright on a flat surface on the branch and tail leaning so the face is a little upward.
- 4 3/8" tall, 4 1/4" deep, 2 5/8" wide, 0.7 ounce.
alt id ST2433980 bird


“Courage is what it takes to stand up and speak; courage is also what it takes to sit down and listen.”
Calgary high school students are learning the power of these words spoken long ago by Sir Winston Churchill.
Annual debates sponsored by the Sir Winston Churchill Society of Calgary are helping build new generations of powerful orators, able to persuade and lead others as the former British prime minister did during the darkest days of the Second World War.
“Churchill’s use of the written and spoken word to persuade, encourage and comfort was a significant factor in what made him a great man,” said society president Steven Robertson. “We think that encouraging debate and teaching students how to debate is an important skill that is not, especially now, available in every school.
“It is also an appropriate way to preserve Churchill’s memory and make an important contribution to modern society.”
This year marks the 50th anniversary of the society, established in 1966 to celebrate the life of Churchill and nurture oratory skills in students. Each year, the society sponsors high school debates centred around an issue Churchill was involved with during his life. The winners will attend the black-tie dinner on Wednesday to receive their trophies, with the top two sponsored by the Calgary Herald since 1973.
In November 2015, various school teams debated whether Churchill’s idea to create the European Union was justified. Bryan Ma and Richard Li, both International Baccalaureate students at Western Canada High School, were the top award winners. Their school won three of the eight medals with the society’s namesake school, Sir Winston Churchill High School, garnering four. Webber Academy rounded out the list.
The guest speaker at the dinner event is Andre Gerolymatos, history professor and associate member of the School of Criminology at Simon Fraser University who has served on the Canadian Advisory Council on National Security. He is also director of the Stavros Niarchos Foundation Centre for Hellenic Studies, and it is in this area that he will be delivering his keynote speech — “Churchill and the Greeks.”
“He has an interesting background in that in addition to Hellenic Studies, he also has a significant interest in national security. I think part of the discussion will be on Churchill’s interaction, relationship with and creation of the secret service,” said Robertson.
Past speakers have included Lady Mary Soames, Churchill’s daughter, his granddaughter Emma Soames and the society’s patron, Randolph Churchill, his great-grandson.
The formal event is at the Ranchmen’s Club, starting at 6 p.m. Money raised from the event goes toward the society’s initiatives to sponsor high school students and post-secondary events that encourage advocacy debates and speeches.
The full list of winners:
Gold: Celena Gong and Hanbo Yu — Sir Winston Churchill High School
Silver: Anna Mouland and Noah Macdonald — Western Canada High School
Bronze: Nashid Islam and Jennah Motani — Sir Winston Churchill High School
Top Speaker: Anna Mouland — Western Canada High School (Principal’s Cup)
Senior Open (advanced):
Gold: Bryan Ma and Richard Li – Western Canada High School
Silver: Anahid Najafizadeh and Akash Uppal — Webber Academy
Bronze: Michael Xie and Sunand Kannappan — Sir Winston Churchill High School
Top Speaker: Navin Kariyawasam — Sir Winston Churchill High School


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Short Communication - International Research Journal of Microbiology ( 2022) Volume 11, Issue 5
Received: 30-Aug-2022, Manuscript No. IRJM-22-74107; Editor assigned: 01-Sep-2022, Pre QC No. IRJM-22-74107 ; Reviewed: 15-Sep-2022, QC No. IRJM-22-74107; Revised: 20-Sep-2022, Manuscript No. IRJM-22-74107; Published: 27-Sep-2022, DOI: 10.14303/2141-5463.2022.19
The pyrolysis of plant materials to produce bio-char has the potential to promote plant growth in soilless media. The effects of bio-char amendments on soilless growth media, the makeup of the microbial community, and the fate of chemical constituents in the media are all, however, poorly understood. This study used meta-genomics and gamma spectroscopy to investigate the chemical components of the microbial composition and soilless media after adding various quantities of bio-char to each (Barns SM et al., 2007).
Under ideal fertigation circumstances, the effects of additions (1–5% by weight) of a nutrient-poor, wood-derived bio-char on pepper (Capsicum annuum L.) and tomato (Lycopersicum esculentum Mill.) plant development and production were studied. When compared to the unaltered controls, pepper plant development in the bio-chartreated pots was significantly improved. Most measured plant metrics, including leaf area, canopy dry weight, number of nodes, and yields of buds, flowers, and fruit, all increased across the board as a result.
Along with the observed improvements in plant growth and production, pepper plants supplemented with biochar also had significantly larger abundances of culturable microorganisms from well-known soil-associated groups in their rhizospheres. Based on 16S rRNA gene analysis, phylogenetic analysis of unique bacterial isolates revealed that 16 of the 20 isolates from the char-amended growing mix's roots and bulk soil were connected to previously documented plant growth-promoting and/or bio-control agents.
Soilless media, Bio-char, Pepper, Plant growth promotion, Bio-char, radioactivity, Thermal stability, Pyrolysis
To minimise net greenhouse gas emissions and diversify energy sources, there is a global push to provide inexpensive energy from renewable resources. Due to its availability, high energy value, and adaptability, biomass outperforms many other renewable energy sources. However, due to substantial inputs of fossil fuels for agricultural production, much first generation biofuel production—i.e., ethanol from sugar and starch crops and biodiesel from oil crops— in temperate regions is nearly totally carbon positive. Therefore, there is ongoing interest in creating second and third generation biofuels that are at least carbon neutral and maybe even carbon negative (Suriya J et al., 2016).
Over the past 55 years, the use of soilless substrate as a plant growth medium has garnered significant interest on a global scale. Individually, in combination, and with additional ingredients like fertilisers, soilless substrates made of organic (peat, compost, coir, bark, and wood fibre) and inorganic (Rockwool volcanic rock, tuff, expanded clay granules, vermiculite, zeolite, and pumice) materials have been used. Peat has always been the main component of container agriculture. Recent worries about its financial burden and environmental effects, however, have led to the adoption of renewable organic materials as replacements (Kumar V et al., 2017).
A carbon-rich charred organic material called bio-char is produced by pyrolyzing waste biomass in the absence or with very little oxygen. A lot of research has been done on adding bio-char to conventional or mineral soil, including reviews and studies. The physicochemical characteristics of bio-char are influenced by the kind of biomass used, the pyrolysis temperature, and the storage conditions. By raising soil pH to enhance soil fertility, altering soil bulk density, and enhancing organic C and cation exchange capacity, biochar affects the physicochemical parameters of soil. Water retention in the soil, better nutrient retention to boost crop output, and changed microbial populations and activities in the soil are further advantages of bio-char. Bio-char's resistance to microbial decomposition has been noted; this controls the amount of carbon dioxide (CO2) that is released into the atmosphere to slow down climate change (Ventura M et al., 2007).
The amount and activity of microorganisms in soil are influenced by a variety of environmental conditions, including temperature, moisture content, and organic matter. The microbial populations in the soil are essential for the uptake of nutrients. Because of their sensitivity to abiotic changes, soil quality, and plant cover, microbial communities are regarded as key biological indicators of stress in terrestrial ecosystems. It's important to comprehend how microbial community diversity and composition relate to environmental factors. By adding bio-char to the soil, it is possible to change and improve the structure and activity of the vital microbial population (Lee SH et al., 2008).
The causes and implications of global population growth, fixed land area, and Agriculture land degradation has been discussed elsewhere. Anthropogenic activities are changing the natural land cover of the world into ecosystems that are controlled by people. According to reports, there were around 13 million hectares of natural land cover. Every year between 2000 and 2010 was changed to different land uses. Though as a Potential soilless-bio-char mitigating method for agricultural land degradation worldwide interest in agricultural amendment systems is growing.
Our findings reveal trends that characterise the microbial abundance of the Proteobacteria phylum in the bio-char modified growth medium, notwithstanding the complexity of ambient microbial ecosystems. Proteobacteria have been shown to be consistently abundant in several examined sites, and their relative abundance was high when compared to other bacterial phyla, independent of the amount of biochar added to the growth media. Proteobacteria are known to aid in nutrient uptake and disease defence while also encouraging plant development. Therefore, in an agricultural context, a low relative abundance of Proteobacteria can have a significant impact on the health of the medium and plant productivity. Proteobacteria have a significant part in the carbon cycle, which is compatible with their high abundance due of the high carbon content in bio-char (Lugtenberg B et al., 2009).
It is necessary to do additional study to comprehend how bio-char soil additions affect plant growth promotion. The majority of research to date has been on the direct or indirect effects of bio-char on plant nutrition. Here, we show that bio-char amendment has a favourable influence on plant response for two crops (pepper and tomato) in a well-structured soilless growing medium, with no function for bio-char in terms of direct or indirect impacts on nutrient content, soil physical characteristics, or water holding capacity. Therefore, it is clear that other mechanisms have a significant impact on the bio-char's reported stimulatory effect, sometimes known as the "charcoal effect." There are two potential explanations for this phenomenon: either the bio-char stimulated the growth of advantageous microorganisms that facilitated plant growth, or the chemicals in the bio-char directly induced beneficial plant responses. Studies are now being conducted to determine the possible role of isolated microorganisms and compounds found in bio-char in stimulating plant growth and inducing disease resistance in these settings.
Copyright: 2022 International Research Journals This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

domain: chemistry


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2021 DIG Research Project | “Heme Oxygenase-1 Regulation of Skeletal Muscle Inflammation and Mitochondrial Fitness in Sarcopenic Obesity”
Heath Gasier, PhD, RD, is a physiologist and assistant professor within Duke Anesthesiology’s Center for Hyperbaric Medicine and Environmental Physiology (CHMEP). His research interests include diving and altitude physiology, nutrition and bone health, and skeletal muscle mitochondrial dynamic regulation in stress. He is a member of the American College of Sports Medicine and the American Physiological Society, and has been a registered dietitian since 2001.
Gasier enlisted into the US Navy after graduating from high school in NE Ohio. He later earned a BSAS in nutrition from Youngstown State University and an MS in nutrition from Case Western Reserve University. In addition, he completed a dietetic internship from University Hospitals Cleveland Medical Center. As a commissioned US Air Force officer, he served as a clinical dietitian at Wilford Hall Medical Center. Heath was awarded a US Navy Health Services Collegiate Program Scholarship to complete a PhD in exercise physiology from Texas A&M University. His area of study was skeletal muscle biology with a focus on in vivo muscle protein synthesis. Upon graduation, he was assigned to the Naval Submarine Medical Research Laboratory as a naval research physiologist. During this time, he served as a principal investigator on research projects directed towards understanding the impact of prolonged submergence on bone and metabolic health, diving and oxidative stress, and the efficacy of nitrates on improving blood flow and muscular performance at high altitude. He also served as an assistant department head and vice chair of scientific review, and scientific integrity officer. Gasier was awarded an out-of-service fellowship in hyperbaric physiology at the Duke CHMEP under the direction of Dr. Claude Piantadosi. During this time, he conducted investigations with Dr. Ivan Demchenko that were focused on identifying the location and mechanisms of oxygen-induced seizures, and the use of antiepileptic drugs to delay seizure onset. He was then assigned to the Uniformed Services University of the Health Sciences as an assistant professor in the Department of Military and Emergency Medicine. There, he began a line of research that was aimed at understanding how heat stress and nutrient excess induced oxidant production influences skeletal muscle mitochondrial dynamic regulation and function. In addition, he performed investigations that were designed to test whether carbon monoxide could preserve bone and skeletal muscle mitochondrial fitness in diet-induced obesity. Gasier served as the director of animal research within the Consortium of Health and Military Performance (CHAMP), and course director of “Warfighter and the Environment” and “Military Field Practicum 101.” He also served as the Navy’s representative for the Department of Defense’s Military and Operational Medicine Nutrition and Dietary Supplement expert panel. In 2019, Gasier retired from military service and returned to the CHMEP with the goal of continuing his research under the mentorship of Drs. Piantadosi and Richard Moon.
Sarcopenia and obesity are conditions whereby oxidative damage and low-grade inflammation are linked to impaired mitochondrial quality control and function. Heme oxygenase-1 (HO-1) induction reduces skeletal muscle oxidant production and inflammation in diet-induce obesity and models of skeletal muscle atrophy. HO-1 is an enzyme system that catalyzes the breakdown of heme, an iron-containing porphyrin and prooxidant, to bilverdin, non-heme iron and carbon monoxide (CO). Bilverdin is rapidly reduced to bilirubin via biliverdin reductase (an antioxidant), and non-heme iron is either stored as ferritin or oxidized by hydrogen peroxide forming oxidants (Fenton reaction). CO is a gas signaling molecule that regulates activation of the transcription factors nuclear factor erythroid 2-related factor 2 (Nrf2), nuclear respiratory factor (NRF)-1 and NRF-2, which coordinately activate antioxidant and inflammatory gene transcription. In addition, HO-1/CO mediated activation of Nrf2 and NRF-1 regulates mitochondrial quality control, the integrated processes of mitochondrial dynamics, mitophagy and biogenesis. It remains unknown whether the skeletal muscle HO-1 enzyme system is impacted in sarcopenic obesity, and contributing to deterioration in mitochondrial population and muscle atrophy.
DREAM Innovation Grants (DIG) support innovative high-risk and potentially high-reward investigations to accelerate anesthesia and pain management research and are made possible through Duke Anesthesiology’s Duke DREAM Campaign. Gasier is excited to have received a 2021 DIG, and expects to generate preliminary data for a more focused, pre-clinical RO1 proposal that is directed towards understanding how the HO-1/CO system regulates cell stress in sarcopenic obesity during illness. This work is supportive of his long-term goal of discovering novel strategies for preserving skeletal muscle mass and metabolic health in obesity and aging.


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domain: food


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BABYMETAL just announced their biggest tour for the United States ever! 20 dates across the US from coast to coast, many revisits, many first timers. The venues are much larger than usual for BABYMETAL, with a total capacity of 72000!!For most of the tour they will have an opening act, Read more…
BABYMETAL plays on Sunday, August 4th on the Super Stage. This will be BABYMETAL’s second show Taiwan (pervious one was in 2014).
After being leaked yesterday, it’s now confirmed that BABYMETAL will play at the Aftershock festival in Sacramento, the same weekend as their The Forum show.
BABYMETAL announces first arena show in the US, plus a festival appearance leak, and they confirm Elevator Girl release
BABYMETAL will play their first arena show in the US in Los Angeles in October, with a festival in Sacramento following 2 days later. They also confirm the Elevator Girl single release.
Fox Day announcements! New album coming this year (no date yet), LEGEND M in July, a couple of shows at Yokohama Arena in June, and an interview with photos too!

domain: geography


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These heavy, no-pil, 100% acrylic cardigans offer classic styling or old-school charm, depending on which you choose. The solid cardigans feature elasticized cuffs and waist. The striped sleeve cardigan features folded cuffs and straight waist. Each is unisex-sized, and so run about a size large. Please order accordingly.
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domain: design


Lapu mayor wants to develop Olango Island into ecotourism hub
CEBU, Philippines — Lapu-Lapu City Mayor Junard Chan announced the city’s interest in developing Olango Island into an ecotourism hub.
Chan said developing an ecotourism hub will benefit the city as it would invite more tourists to stay in Lapu-Lapu.
“Instead ang mga langyaw nga mga bisita nato inig abot dinhi sa Lapu-Lapu City, instead nga molabang didto sa Bohol, they will stay here sa Lapu-Lapu and go to Olango kay atong developon ang Olango as an ecotourism [destination],” Chan said in his speech during the flag raising ceremony at the city hall grounds on Monday, January 6, 2020.
(The foreign tourists, instead of going to Bohol, they will stay here in Lapu-Lapu City and visit Olango Island instead because we will develop it into an ecotourism destination.)
Olango’s southern tip hosts the Olango Island Wildlife Sanctuar (OIWS), a major refuelling station for migratory birds from Siberia, northern China and Japan.
Around 40,000 migratory birds visit the island every year.
“Olango Wildlife Sanctuary supports the largest concentration of migratory birds found so far in the Philippines. There are 97 species of birds in Olango, 48 of which are migratory species, while the rest are resident birds of the island,” said the OIWS official website.
OIWS covers the coastal area of Olango’s Barangays San Vicente, Sta. Rosa, Sabang and Pangan-an.
OIWS is a declared protected landscape and is managed by the Department of Environment and Natural Resources (DENR).
Currently, OIWS offers bird watching and trekking activities. /bmjo
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Phil Babb is recognised as one of the UK’s leading children and baby photographers. Existing clients return year-on-year and his client base is constantly expanding - testimony to his unique skills as a genuine specialist in this field.
Phil combines gorgeous imagery with great service from his production team, exceeding clients' expectations and delivering successful shoots on time and on budget. He has had a great start to 2011 working with clients both old and new, and his images are used globally across packaging, POS, brochures and advertising.
Phil's website showcases six galleries including commissioned work and his full client list.
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As the Elliniko development on Athens’ southern coast gets on the road toward its implementation and more and more details come to light, the magnitude of this colossal endeavor is starting to become apparent. What it entails, in fact, is the construction on the plot of the old airport of a brand-new city, twice the size of the Principality of Monaco, covering an area of 2.7 million square meters.
You don’t need to get into the nitty-gritty to understand the cumulative impact on the Greek economy of what will possibly be the biggest urban development project in Europe.
For most Greeks, the news of the recent signing of the implementation agreement brought a sigh of relief. Finally, a vast expanse of land that has lain abandoned and unused since the 2004 Olympic Games, in one of the most privileged locations in the Greek capital, is being turned into an engine of growth, both for Attica and the country as a whole. At first glance, everything looks promising: massive economic benefits, hand-in-hand with a positive environmental impact, as the plot will also host the biggest metropolitan park in the country. But is it as rosy as it first appears?
If the focus of international investors turns to Elliniko, isn’t there a risk of interest in central Athens diminishing? If we suppose that the funds earmarked for investment in a specific country or metropolitan area are finite, is it possible that the Elliniko development will absorb millions of euros year after year, leaving Athens looking like the poor relative at the investment party? Could what we dreamed of with such certainty – that Athens would finally embrace its coastal zone – turn into an economic nightmare for the city center?
In theory at least, the capital being attracted by Elliniko right now is unlikely to have ever been destined for areas inside the boundaries of the City of Athens. In that regard, Elliniko is not taking away money that would otherwise go into the city center. That, however, is only half the truth, because the development will gradually acquire massive economic, social and tourism momentum that will inevitably draw indirect investments away from Athens.
This may not be such a bad thing, correcting distortions like paying 400 euros rent for a basement apartment in Pangrati. But in strictly economic terms, we may see a race unlike anything we’ve seen before and Athens needs to be in form to hold onto the gains it has made so far.


The Hollywood Reporter has confirmed that troubled starlet Lindsay Lohan is in talks to portray the late classic Hollywood legend Elizabeth Taylor in an upcoming Lifetime movie. [photogallerylink id=37468 align=left]
So now we want to know, do you think Lindsay Lohan could pull off playing a big screen legend of the classy caliber as Taylor, or is this a casting disaster waiting to happen?
The movie being overseen by independent producer Larry Thompson, is currently in development and is talks with Lohan to play the classic Hollywood actress who passed away last March.
Lohan, who just posed as another Hollywood legend in a Marilyn Monroe inspired Playboy spread, has mostly been in the news for her legal troubles in recent years, including the most recent jail sentencing, which she served only 4 1/2 hours before being released due to overcrowding. She’s currently working community service hours at the L.A. County Morgue and attending therapy.
So we want to know, do you think Lohan is a good match to portray Liz in a made-for-TV Lifetime movie, oris this a casting disaster?Vote below!


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Lookinfg for Best Sandals Resort In Barbados?….If you’ve been exploring sandals resorts and you’re questioning which is the best resort well you are in the best location hi i’m addison from reliant destinations and mycaribbeanluxury.com i’m so grateful you’re here as a certified shoe specialist who has visited all the sandals resorts i’m pleased to share with you today my top 5 Sandals resorts before i enter my leading five ranked sandals resorts i wish to motivate you to have a look in the description listed below there you will find links to the very best due online and also the present specials you will also find stunning digital brochures for the five resorts that i will list let’s begin number five sandals botego bay identified as the true beachfront resort where the celebration never ever stops See this is the original sandals resort back in the 1980s but you would not
recognize it today this resort has had many refurbishments that out of the present 15 sandals resorts it is one of the best resorts in the portfolio when staying at sandals motego bay you also have a special feature in the truth that you have remain and play advantages with sandals royal caribbean with this it Implies you have access to a standard high-end jamaican resort like sandals rural caribbean obviously with the extremely unique elements there like the over the water bungalows and after that sandals botego bay which is now very redefined high-end luxury obviously i ‘d be a sucker not to mention that my preferred restaurant exists at sandals store bay which is butch’s Chop home this is a great dining advanced steakhouse called after the recently passed creator of beaches and sandals resorts gordon bush stewart one unique feature about sandals shop bay is that for the majority of club and all butler suites at this resort you really get private bmw transfers from the airport so if you like to show up in style this Is the method to go number 4 sandals grand antigua recently voted the world’s primary the majority of
sandals resort beach in barbados
romantic resort this gorgeous resort located on dickinson bay is not to miss high-end and relaxation are at the heart of a stay at sandals grand antigua this resort is well-known for the butler sweet plunge pools that you’ll find across this resort Additionally sandals grand antigua features the eastern caribbean’s biggest pool 15 000 square feet of pure clear paradise number 3 sandals grand st lucian the tagline sandals has actually provided this resort fits it well grand views on its own peninsula from sea to shining sea this resort is near rodney bay in the magnificent saint lucia if you’re not aware st lucia is popular for The piton mountains which is a unesco world heritage site you’ll see this wonderful topography across the island making it perfect for regional expeditions even much better this resort is literally next door to pigeon island where you can do some very really cool checking out not to mention that sandals grand st lucian is actually one of three sandals resorts that includes Over the water cottages if you want to take a tour of among those cottages just take a look in the link above possibly the most attractive feature about santa’s grand st lucian is the stay and play privileges see there are two other sandals resorts also on the island when remaining at sandals grand salution you get complimentary access to sandals
richard sila talk And sandals halcyon beach with sandals houston beach using a small intimate paradise and sandals stiff sealant talk offering splendid cliffside views you are due to get 2 really unique experiences when you stay at sandals grand st lucian naturally i ‘d be a miss out on if i didn’t point out that the stay and play advantages here in st lucia means you have an overall of 27 various restaurants To pick from on any night of your selecting second sandals grenada if i must be truthful sandals grenada is actually tied for number one but might be available in hardly at number two see this resort has been rated the world’s most innovative extensive resort sandals grenada features a few of the most architecturally special and unique suites i would argue in the whole world This spice island resort also features 10 unique dining establishments of which it likewise has butch’s slice house my favorite can we take a moment and simply appreciate how gorgeous this pool is and all ideal ladies and gentlemen we are at top sandals royal barbados i believe the tagline for this resort states it
best all sweet all high-end all On a jet setter destination see at the time of this video sandals royal barbados is likewise the latest sandals resort sandals royal barbados was developed as a connected complex to the initial sandals barbados which is likewise a fantastic resort truly you will find some things here at sandals royal barbados that you just actually can’t get somewhere else yes sandals has taken the premium All-encompassing principle to a whole brand-new level at sandals royal barbados great dining donut shops craft beer sampling bars the caribbean’s only personal and consisted of bowling alley an enormous beachfront glass infinity swimming pool a nearby sky rooftop infinity pool with a bar right by it serving liquid nitrogen cocktails for me it really does not improve than this You likewise don’t need to convince me two times when you tell me there are 2 british leading houses here one situated in sandals barbados and one in sandals royal barbados as one substantial complex you have access to the stay and play opportunities of the facilities at both resorts so there you have it folks my rapid fire analysis of the leading 5 sandals resorts if you have Any concerns or if you would like me to hold a space totally free for you while you make your last choice simply let me understand all my details and links that you want to see are in the description listed below please remember to like this video and subscribe i will see you next time [Music] you Best Sandals Resort In Barbados
Restaurants within jamaica whilst on vacation in the caribbean, antigua and st. lucia
Minutes from the montego bay airport you have all sort of various dining establishments lounges bars an unbelievable beach some incredible beachfront vacation homes suites and rooms we’re going to reveal all of that to you today so follow along as we tour the resort let’s kick it off in the heart of the caribbean town you have this renowned spot here at sandals montego bay this beautiful Swimming pool and of course infinity edge hot tub i love sitting here and taking advantage of these extraordinary views and naturally every terrific all-inclusive needs an extraordinary swim up bar and this is one the bartenders are definitely fantastic it goes from in the morning all the way into the night this is a main hub celebration going on at various times of the day and what i like about this specific pool is it’s unlike any other Here on the residential or commercial property so it begins here however it really covers all the way around they have actually got bench seating set throughout the pool and you have actually got these channels that meander all the way around the back here and even wrap around the bar location now set simply behind the swim up bar you’re going to discover the piano bar this location truly gets going at night got the piano going sing-alongs having a Great time with friends and after that obviously you’re just a couple of steps off the beach below this gorgeous tree they have market lights established and you have actually got this terrific fire pit location as well where you can listen to the sounds of the ocean lapping in the distance fantastic location to unwind at night perhaps before dinner or after especially if you’re heading over To the piano bar set simply next to the piano bar and right here on the beach you have the jerk shack this is one of those traditional sandals choices where you get to explore a little bit more about jamaica the jerk chicken and pork i had here was the other day was definitely tasty and what i like is they have an extremely
simple and small menu but they get it precisely best set just in front of the bar and hot tub you have This narrow stretch of beach right here and one of the things that i love about this specific part of the beach is that you have actually got the loungers and palapas they’re right on the water you can head right out into it now we’re going to get to the much larger part of the beach too but this is completely situated beside the bar the jerk shack and then you got the latitudes bar simply behind me now if you wish to get a drink and head out And enjoy it in the water there’s some excellent choices here you see you have actually got these two hammocks i love being in them you’re simply a little bit in the water there you can dip your toes in and after that continuing along down you have actually got these swings naturally they’re.
spa grenada by the ocean dinin on negril in montego bay
iconic for photos maybe you need to discover that best instagram area however what locations better place to sit Relax and check out these gorgeous ocean views now if you’re looking for a change in mindset and naturally a change in latitude i extremely recommend you have a look at latitudes this is my preferred bar here on the whole resort and you can imagine why it’s an over the water bar they have these fantastic catamaran internet all the way around and for me personally there’s couple of places on the planet that Lower my blood pressure and make me delighted like a catamaranette you have great bartenders they were a lot fun last night had me cracking up and laughing this place was hopping and as you continue out onto the pier in addition to all the seating around the bar the couches the bar stools and then the bar stools facing out you likewise have these great nooks so you have actually got a fire pit right Here you’ve got actually comfortable chairs and loungers all around we do a lot of groups here a lot of weddings buddies groups and you can see there’s all of these wonderful spots tucked around and then naturally there’s some areas for 2 right on the internet you can sit and have a great romantic day now if you believe this specific area is lovely during the day I extremely suggest that you check it out in the evening they’ve got light set all the way around romantic and truly gorgeous and all around this extraordinary location last night we satisfied buddies we had a good time it’s just a fantastic choice whenever of the day now if your dream wedding event involves a little white wedding chapel and obviously an over the water bungalow this may be the perfect area for you They can fit several guests in here but the unique function is that in addition to the glass windows all the way around with the extraordinary views you also have a glass bottom flooring too now i enjoy all of the. Best Sandals Resort In Barbados
alternatives that they have here on website and no one does it quite like sandals particularly with the additions we’ll deal with all the information for you however i simply wished to mention this unbelievable spot Now for smaller sized and more intimate weddings or for a romantic supper they have these two gorgeous palapas you have actually got the first one over there to the left you can see it’s right on the edge of the home there and after that on the other side set simply in between the chapel and the over the water bar you have another lovely spot you can imagine candlelight at night or of course that lovely sunset wedding This might be the spot for you now after you get married you really get to head on out and discussing wedding bells they even have a substantial one [Music] [Applause] what an ideal method to begin your marriage another great alternative is you have this lovely structure stashed out at the very end of the pier this is another stunning renowned area To get wed have a vow renewal or a romantic supper in the evening so now we’re inside the stunning lobby here you have a high roofing they’ve got lights. it’s actually a terrific space during the day and in the evening you’ve got a lots of seating here where you can spread out they have actually got a present store back there and then naturally the commitment and travel desk our visitors come down here all the time And they love to come back we extremely advise that you rebook on website and then of course as soon as you get back you simply let us know and we’ll take care of all the details from there you’re likewise going to discover the island’s root desk in here also that’s the expedition desk where you can get all kinds of details however we’re going to prepare all of that for you prior to you get here so when you get here you do not need to Fret about anything now i love this indication here sandals montego bay where it all began established in 1981. there’s a factor that 40 years later this is such an amazing resort and you understand what the setting is absolutely gorgeous they put a lots of cash into upgrading this whole resort but it’s constantly about individuals the staff here have an amazing time one of my favorites is each time you Hear an airplane pass you get the little wave up there it’s actually rather amusing but i have been on my toes given that i’ve been here i have actually been chuckling chuckling it’s simply an amazing.
Beachfront plantation of scuba diving and golf
time here and now i know why my consumers come back time and again as an extension of the lobby you have the beautiful lobby bar you can begin right as soon as you get here Or of course you can come back anytime it’s specifically popular before and after supper among my preferred parts about that is obviously you’ve got the seating there at the bar however you likewise have this excellent lounge seating all around the lobby and you also have a more continuation of that lounge that heads all the way out to the beach front you have actually got a beautiful fire pit you have actually got the couch established huge comfortable Chairs ideal location to collect with a group this is such a popular destination for weddings and groups because individuals can come out they can collect either prior to or after any of the events and have an excellent location to meet up also now as continuing along you’re going to find the outside seating location for bayside now bayside is one of those sandals classics it’s a breakfast lunch and Dinner restaurant typically has a buffet and an a la carte alternative also however if you wish to sit outside here this is an incredible choice you have actually got all of the tables and chairs set up here with the umbrellas you can benefit from those. Best Sandals Resort In Barbados
stunning ocean views and you likewise can get that wonderful breeze coming off the ocean i find the atmosphere is especially Beautiful here at night so now i’m just within bayside this is a casual dining venue here there’s a ton of seating here inside in fact it is the biggest restaurant here on site now for breakfast this is established as a breakfast buffet you have actually got your made to order egg station over here had an actually great omelette today and after that throughout the space they’ve Got stunning seating here now for lunch you have a rotating menu so it’s just inside they really typically don’t have the outdoors open it’s nice and air conditioned in here imagine why you ‘d desire it for lunch however what i like about this is they do a turning menu so every day it’s a bit different the jamaican menu today was absolutely out of this world now they have supper.


text: technical tips. Hubbard Glacier This tidewater glacier may be a bit of sleeping giant. Off the coast of Yakutat—200 miles NW of Juneau—Hubbard is certainly gigantic it s more than six miles. Ohio OH Luxury Exotic and Classic Car Rental Columbus. Ohio car rental, luxury, classic, exotic car rentals and limousine services. C & C towing Hubbard, C and C Towing at offers heavy to light duty towing and flatbed service in hubbard, boardman, youngstown, warren, niles, austintown, canfield, poland.


USAV FORT MCHENRY
Cargo ship, MMSI 368742000
The current position of USAV FORT MCHENRY is at North America West Coast (coordinates 37.79041 N / 122.28831 W) reported 63 days ago by AIS. The vessel is sailing at a speed of 0.1 knots.
The vessel USAV FORT MCHENRY ( MMSI 368742000) is a Cargo ship and currently sailing under the flag of United States (USA).
Position & Voyage Data
USAV FORT MCHENRY current position and history of port calls are received by AIS. Technical specifications, tonnages and management details are derived from VesselFinder database. The data is for informational purposes only and VesselFinder is not responsible for the accuracy and reliability of USAV FORT MCHENRY data.


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Grayson Joslin is a freshman political science major and writes “Soapbox” for The Daily News. He is also a senator for Ball State’s Student Government Association. His views do not necessarily reflect those of the newspaper.
Since fifth grade, I have wanted to be a leader.
What started as a letter to former President Barack Obama in late 2013 turned into my passion: to help people’s voices be heard and understood.
Wherever I was, I wanted to motivate my fellow peers and make meaningful change.
When I arrived at Ball State last fall and joined the Student Government Association (SGA), I ran into something that I had not come across before in my time as a student leader: stagnation inside student government and disinterest from students.
In previous years, there has been unspoken animosity between SGA and the Ball State students at large. One prominent example occurred in December 2019, when SGA considered a resolution calling on the University Senate to change the student conduct code to adopt a zero-tolerance policy to fraternity and sororities on campus. This policy would penalize Greek life organizations by suspending recognition of a chapter if they were found to have committed sexual assult or hazing.
The amendment was passed and sent to the University Senate for further review, but as of now, they have not adopted the guidelines into the code.
This is not just an organization despised due to the zero-tolerance amendment more than two years ago; this is also the same organization that had the president resign over derogatory tweets towards Chinese culture almost a decade ago. SGA has been on a decline due to these controversies and more that go back years.
This dissent has negatively affected both representatives and the represented, especially in regards to voter turnout in SGA elections.
Three of the past five elections, including the last two, have seen only one ticket run and win by default. The Elections Code states that if only one executive board ticket runs, then the option of no confidence is added. The no confidence choice states the student voting feels that the sole ticket is not qualified to lead SGA.
The no confidence option has never received more than 30 percent of the vote when available. Because of this, when one ticket runs, they are the only credible option.
The nadir came in 2021, when only 644 students voted in the SGA election, a single ticket affair. Using the fall 2020 enrollment figures —which counted 15,780 undergraduate students— only 4 percent of eligible students voted in the election.
The voting turnout didn’t improve significantly this year — only 724 students cast their votes in another single ticket election.
When students see the low voter turnout, they further lose faith in SGA. It feels like “Groundhog Day,” but this is not a laughing matter. In a democracy, it is healthy to have competition for elections. It allows the public to have choices and hold those in charge accountable.
Plain and simple, SGA is not a healthy democracy.
There may be many causes as to why SGA is distrusted, but the most pressing to me is the fact that, due to the increase in single-ticket elections, the choice on who to lead is already decided before the election season begins.
The SGA constitution states the purpose of this organization is “be the voice of the student body.” However, when I have asked people across Ball State throughout this year about SGA, the most common response is, “We have a student government?”
That alone should be overly concerning.
However, SGA is not the only group at fault. The student body does not understand the functions of SGA or the limits of their powers. The student body’s lack of dedication into learning about SGA has also added to this issue. Each side needs to take blame and accept responsibility for the shortcomings that have happened in previous years.
I recognize why most students are oblivious to our student government. Most of what SGA has considered in the past few years have been amendments micromanaging its own governing documents, rather than resolutions calling on the University Senate for considerable change for students on campus.
Amendments establish changes in the governing documents for any number of reasons while a resolution voices SGA’s opinion or calls to action matters occurring at Ball State outside of SGA’s jurisdiction. An example of a resolution that actually works for SGA’s constituents came in December 2021, when the Student Senate passed a resolution calling on the University Senate to raise the minimum wage to at least $9 an hour.
Over the past two academic years, there have been 53 amendments considered in the Student Senate. On the contrary, only six resolutions were considered during the same period.
This is unacceptable when SGA’s flagship goal is to “advocate and bring attention to issues of concern on behalf of the Student Body,” per the SGA Constitution.
Worse, SGA’s leadership has reaped rewards while the campus remains underserved by its representatives.
The five executive officers of SGA — the president, vice president, chief administrator, treasurer and president pro tempore — receive stipends equal to two-thirds of current in-state tuition. The fact the executive board is being reimbursed for what some students might say is not enough done to help the student body might turn people away from SGA.
The fact that we have allowed SGA’s reputation to sink this low is embarrassing, disappointing and infuriating. Other Indiana schools such as Purdue and Butler have seen some of their highest election turnouts in recent memory the past two years, so what is stopping us from having these impressive turnout numbers too?
You, the students, have a voice. Be compelled to use it. SGA needs to listen to the student body’s concerns, and the student body needs to press SGA at every turn.
I propose to you this — be an outsider and run for SGA office.
Outsiders running in the SGA election is not a novel concept. In the 2020 SGA election, one slate stood out from the rest: Alliance.
The ticket consisted of students who did not have experience in SGA, and their approach to campaigning has influenced the previous two elections, as shown by executive tickets shifting from platform points to platform focuses. Alliance did not win, however, placing second in the runoff elections as the more experienced Bold slate took victory.
I do not want to stick with the status quo. It is not working, and we must try something different to change student leadership for the better at Ball State.
I see a future for SGA, a bright outlook where we are the model student government organization, where other colleges want to be like us. There is a lot of work to be done to build back up the prominence of SGA at Ball State, but I am confident in the student body’s willingness to shape this university into a better place for all.
Contact Grayson Joslin with comments at email@example.com or on Twitter @GraysonMJoslin.


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Assistant Professor, Rama University, Kanpur
Expand for Article Information
Author: Parul Nigam
Journal: Pexacy International Journal of Pharmaceutical Science
Volume/Issue: Volume 2, Issue 5
Page Range: 12-23
Publication Date: 12/05/2023
Abstract- The limited solubility of Rebamipide, a therapeutic agent used for treating gastrointestinal disorders such as peptic ulcers, often restricts its bioavailability. This study focuses on enhancing the solubility of Rebamipide through the development of solid dispersions using polyethylene glycol 4000 (PEG-4000) and polyvinylpyrrolidone K-30 (PVP K-30) as hydrophilic carriers. Various formulation techniques, including solvent evaporation, co-precipitation, and melt extrusion, were employed to prepare these solid dispersions. Comprehensive physicochemical characterization was performed to assess the properties of the formulated dispersions. The study found a marked increase in the solubility and dissolution rate of Rebamipide in the solid dispersions compared to its pure form. The optimized solid dispersion formulation, particularly with PEG-4000 and PVP K-30, exhibited enhanced bioavailability in pharmacokinetic evaluations. These findings suggest that the use of PEG-4000 and PVP K-30 in the formulation of solid dispersions for Rebamipide can significantly improve its solubility, thereby offering a promising avenue for more effective treatment of gastrointestinal disorders.
Keywords- Rebamipide, Solid Dispersion, PEG-4000, PVP K-30, Solubility Enhancement, Bioavailability, Gastrointestinal Disorders, Solvent Evaporation, Co-precipitation, Melt Extrusion.
Article can be accessed online on: PEXACY International Journal of Pharmaceutical Science
*Corresponding Author- firstname.lastname@example.org
Update: Received on 04/05/2023; Accepted; 09/05/2023, Published on; 12/05/2023
In present scenario, tablet is considered as one of the best solid dosage forms due to its easy preparation method and administration1. From all the types of tablet, the oral disintegration form is the most acceptable and suitable for all the age-group of patients. With the help of saliva in the mouth these can easily be disintegrate and dissolved2. This class is also useful for sustained action treatments, for example in case of dysphagia. If the solubility of such class of drug has been increased, it will be more useful and acts more rapidly3. To increase the disintegration and pharmacokinetics of this class of drugs, solid dispersion technique has been used. By performing this technique, not only the dissolution rate of drug increases but also the chances of toxicity will get reduced4.
Solid dispersion has been defined as “Dispersion of one or more active substances in a hydrophilic transport or substrate generated by fusion, solvent, or melting solvent technique in a solid state.” Solid dispersion increases porosity of the drug and hence, solubility also increases. It is also responsible for transforming insoluble drugs into an amorphous state, which allows for greater solubility5. Enhancing the wetting properties of the substances surface, as well as particle size reduction and improving the interfacial area accessible for drug dissolution, can help increase drug dissolution rates from a solid dispersion6.
Materials and Methods
Rebamipide was purchased from Global Scholar Scientific Solutions, (Lucknow); Polyvinyl Pyrrolidone K-30 from Yarren Chem Products, (Mumbai); Poly-ethylene glycol 4000 from S.D. Fine-Chem, Ltd, (Mumbai); Potassium dihydrogen phosphate from Merck Ltd., (Mumbai); Ethanol from Changshu Hongsheng Fine Chemical co. Ltd.; Sodium hydroxide pellets and Hydrochloric acid from Thermo Fisher Scientific Pvt. Ltd. (Mumbai).
The methodology comprises of following steps-
- Preparation of Calibration Curve-
- Preparation of std. curve in phosphate buffer
- Preparation of std. curve in 0.1N Hcl
- Preparation of Solid dispersion by solvent evaporation method
Preparation of Calibration curve
The preparation of calibration curve of pure drug was performed with the help of UV spectroscopy.
- Preparation of standard curve in phosphate buffer (pH 6.8)
10 mg of drug Rebamipide was accurately weighed and placed in a100 ml volumetric flask containing some amount of solvent then made the volume up to 100ml with phosphate buffer. The standard stock solution thus obtained was then serially diluted with phosphate buffer to get 2,4,6,8,10μg/ml.The absorbance of the solution was determined using phosphate buffer as blank,at 226nm.The absorbance value was plotted against concentration to obtain the calibration curve.
- Preparation of standard curve in 0.1 N HCl
10 mg of drug Rebamipide was accurately weighed and placed in a100 ml volumetric flask containing some amount of solvent then madethe volume up to 100ml.The standard stock solution thus obtained was then serially diluted with 0.1 N HCl to get 2,4,6,8,10μg/ml.The absorbance of the solution was determined using 0.1N HCl as blank,at 224nm.The absorbance value was plotted against concentration to obtain the calibration curve.
Preparation of solid dispersion by solvent evaporation method
Rebamipide solid dispersion were prepared by solvent evaporation method. Different carriers(PVP K-30, PEG-4000) used in different ratio as shown in table (1). The drug and carrier were taken separately in different ratio(1:1, 1:2, 1:3) wt:wt and transferred into motar pestle and triturate to form a mixture. Add 25 ml of ethanol and mix properly. The content transfer into a beaker and heat for 5-10min at 30-40˚C.The solvent was removed by leaving it for 24 hr .The dried solidifing mass were scraped,crushed and grinded in mortar and pestle and pass through sieve no 60 and store in closed container.
|Formulation code||Drug(Rebamipide)||PEG-4000||PVP K-30|
Characterization of solid dispersion
(a) Partical size determination
The particle sizewas determined using optical microscopy. A tleast 100 particles of solid dispersion were counted for precise size distribution.
(b) Determination of production yield
The production yield of solid dispersion of various batches were calculated using the weight of final product with respect to the initial total weight of the drug and polymer used and percent production yield were calculated as per the formula mentioned below-
Percentage yield = Practical yield/ Theoretical yield*100
(c) Determination of drug content
A sample of dried 10 mg of solid dispersion was taken in a 10 ml volumetric flask containing some amount of phosphate buffer pH6.8 and made up volume up to 10 ml with phosphate buffer.Filter it through the whatman filter paper.Drug content was determined by UV spectrophotometer at 226nm.
(d) Solubility studies
An excess amount of pure drug and prepared solid dispersion were placed in contact with 10 ml of 0.1 N HCl and phosphate buffer in a closed container. The suspension were sonicated for 15 min and kept at constant temperature (37±0.5˚C) in a water bath. After 72hr. the suspension were filtered and diluted appropriately and quantified by UV spectroscopy at 226nm.
Standard solution of Rebamipide was prepared by dissolving 10 mg of drug in 100ml of 0.1 N HCl .The final concentration after dilution was 10μg/ml.The λ-max of Rebamipide was to be found 224nm.
Figure 1- UV analysis of Rebamipide
Calibration curve of Rebamipide in 0.1N HCl
STOCK SOLUTION (1) – 10 mg of Rebamipide dissolve in 100 ml of 0.1 N HCl to get the solution of 100μg/ml.
STOCK SOLUTION (2) – From stock solution (1),we take 10 ml and dilute up to 100ml with 0.1 N HCl to get the solution 10 μg/ml. From stock (2) we take 2,4,6,8,10ml and transfer to the 10 ml volumetric flask and final volume made with same solvent, then we get drug concentration 2,4,6,8,10μg/ml. The absorbance value of respective concentration at the wave length 224nm and plot the calibration curve.
Calibration curve of Rebamipide in Phosphate buffer pH6.8
STOCK SOLUTION (1) – 10 mg of Rebamipide dissolve in 100 ml of phosphate buffer to get the solution of 100μg/ml.
STOCK SOLUTION (2) – From stock solution (1),we take 10 ml and dilute up to 100ml with phosphate buffer to get the solution 10 μg/ml. From stock (2) we take 2,4,6,8,10ml and transfer to the 10 ml volumetric flask and final volume made with same solvent,then we get drug concentration 2,4,6,8,10μg/ml.The absorbance value of respective concentration at the wave leanth 224nm and plot the calibration curve.
Figure 2- Standard plot of Rebamipide in phosphate buffer
Particle size analysis
Particle size was determined using optical microscope. At least100 particles of solid dispersion were counted for precise size distributation. The particle size distribution of solid dispersion of F1 to F6 was found to be 70μm, 65μm, 45μm, 67μm, 63μm, 37μm respectively.
Production yield of solid dispersion determined for all formulation F1 to F6 70.1% to 85%.It was indicated that the formulation F4 has higher production yield.(shown in below table)
Drug content studies
The drug content studies was determined in phosphate buffer through UV-spectometer at λ-max 224 nm. The percentage drug content shown in below table:
The solubility studies of Rebamipide and all the formulation was studied in both solvent (i.e. 0.1 N HCl and Phosphate buffer pH 6.8).
In 0.1 N HCl the formulation F3 shown good solubility while in solvent phosphate buffer the formulation F5 show good solubility.
Solubility data in 0.1N HCl :
Solubility data in Phosphate buffer (pH 6.8):
IR spectra are important record which gives sufficient information about the structure of a compound. FTIR spectra of solid dispersion (Rebamipide and poly ethylene glycol 4000) were obtain using FTIR spectrometer.
FTIR Spectral data of solid dispersion
|3269||O-H stretching carboxylic acid|
|2881||N-H stretching amine|
|1725||C=O stretching aldehyde|
|1643||C=C stretching alkene|
|1540||N-O stretching nitro compound|
|1466||C-H bending alkane|
|1422||O-H bending carboxylic acid|
|1279||C-O stretching aromatic ester|
Scanning electron microscopy (SEM)
SEM pictures of selected formulation (F5) was presented in below figure. It showed irregular shaped glassy appearance in addition to size reduction. The smaller particle size lead to great the wetted area, and hence the better solubility.
The drug (Rebamipide) have potent anti-ulcer property but fails to show the desired action due to less oral bioavailability.
The physiochemical evaluation of drug concludes that it belong to BCS-IV system i.e. low solubility low permeability and among the present conventional drug delivery system the solid dispersion was found as one of the best carrier system for the delivery of drug through oral route.
As per the data obtain from the evaluation study it was found that among the prepared set of formulations F1, F2 ,F3, F4, F5, F6 the formulation F5 possess best result in reference to estimation of drug content, formulation F3 possess good solubility in .1N HCL, Formulation f 5 showed better solubility in PBS (6.8) as compare to pure drug.
The above experiment conclude that the incorporation of drug within the system enhances the solubility of drug molecule.
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