text:
SN has announced its Category Excellence Awards for a large number of suppliers who serve food retailers’ increasingly complex needs in a wide range of categories. Among those receiving top honors, General Mills was recognized in the cereal category, Bayer won for over-the-counter medications, and Dean Foods was cited for the dairy category. There were 56 winners overall in 28 categories. Winners were chosen by SN editors based largely on retailer feedback via a survey and interviews. SN identified the key attributes each supplier brings to the table, such as shopper insights, innovation, focus on costs and collaboration. Full details are available in the Oct. 6, 2008, issue of SN.
Read More of Today's Headlines


text:
Cryptocurrency lender Celsius Community was promoting yields of 17 per cent proper as much as mid-June when it froze withdrawals after which filed for chapter in New York one month later.
Advertising itself very similar to a financial institution however with out the identical rules, it attracted a worldwide buyer base — together with Australians — lots of whom had their belongings locked up as cryptocurrency costs collapsed and the corporate ran aground.
The plight of those retail buyers was spotlighted in latest weeks by software program engineer and frequent cryptocurrency critic Molly White, who started to tweet shifting excerpts from lots of of letters despatched to the New York chapter courtroom and shared in courtroom displays.
“The stereotype of people who find themselves placing cash into crypto is … younger, technologically savvy males,” Ms White informed the ABC.
“And that didn’t appear to be the demographic within the letters.
“There have been additionally lots of people who have been saying, ‘that is my life financial savings, my pension, I labored 10, 20, 30 years to save lots of this cash.'”
Ms White additionally shared letters from individuals who mentioned they have been based mostly in Australia, lots of whom described their utter desperation and even ideas of suicide after they have been blocked from accessing funds.
One girl mentioned the influence on her household had been extreme. She included an e mail she despatched to Celsius administration begging to be allowed to withdraw a few of her funds. The e-mail included an ultrasound image of her unborn baby.
Others wrote of their emotional turmoil:
“I’ve misplaced the whole lot. How can I clarify this to my son? I really feel ashamed at myself.”
“That was our life financial savings. It was our probability of getting a child, and funding medical bills. It was our probability of caring for our dad and mom as they age.”
A father of three in Australia wrote he had “his life financial savings in a Celsius earn account”, and that he’d additionally satisfied his father to deposit cryptocurrency belongings into Celsius as a “protected haven”.
In addition to placing a private face to the cryptocurrency crash, lots of the letters cite the web presence of Celsius chief government Alex Mashinsky as a key motive for investing.
They bring about up his common YouTube AMA or “ask me something” periods, during which he projected supreme confidence till the tip, and a willingness to name out what he noticed as “misinformation” about his firm on Twitter.
Ms White was additionally struck by what number of letters particularly cited Mr Mashinsky, and his on-line persona.
“These [AMA sessions] clearly labored very well to construct belief in him and within the platform,” she mentioned.
“And folks principally believed that Alex Mashinsky as an individual wouldn’t do that to them.”
‘We’re on the backside, and we’re attempting to be loud’
Claire* is among the Australians with belongings locked up in Celsius who wrote to the decide.
She returned to Australia in 2020 after greater than a decade dwelling in the USA, and was after a profession change. A college course in monetary expertise launched her to cryptocurrencies, and she or he took a shine to the business.
However Claire mentioned she struggled to discover a job within the discipline and when attempting to begin her personal companies, discovered that Australian banks would not lend to her attributable to a scarcity of native credit score historical past.
A US cousin launched her to bitcoin mining, and she or he ended up locking away round $US50,000 value of bitcoin as collateral for a mortgage from Celsius.
“I used to be very interested in their mortgage facility, as a result of I could not get a mortgage right here for something,” she mentioned.
“Cryptocurrency for an individual who’s in that scenario is … extra engaging.”
Whereas she will not be in as dire a scenario as another Celsius clients, Claire mentioned the purpose of writing her letter was to make sure the voices of smaller buyers have been heard as the corporate’s money owed are thought-about.
It is nonetheless unclear how the method will play out.
Celsius’s phrases and situations warn that an account with the corporate is “not a checking or financial savings account, and it isn’t coated by insurance coverage in opposition to losses” and that “any Eligible Digital Belongings … will not be recoverable” after chapter.
“The massive guys will get the attorneys and they are going to be loud,” she mentioned.
“We’re on the backside, and we’re attempting to be loud.”
Threat not over for Australian buyers
Celsius had roughly 300,000 energetic customers with balances of greater than $US100 ($144) as of July 2022, and a $US1.2 billion shortfall when it filed for Chapter 11 chapter within the Southern District of New York.
The corporate supplied various companies, together with the power to borrow in opposition to cryptocurrency belongings transferred to the corporate, or to earn excessive reward charges on these deposits.
However whereas its group offered a shiny image of giant yields, it appeared unimaginable to some critics that such numbers may very well be sustained with out making doubtlessly hazardous funding decisions with the funds of its worldwide depositors.
Campbell Harvey, a professor of finance at Duke College, mentioned the Celsius scenario was in the end easy: “It is a firm that principally took buyer deposits, if you wish to name them that, after which invested in very dangerous merchandise.”
Amongst different points, Dr Harvey mentioned, Celsius seems to have invested in cryptocurrency merchandise that have been extremely illiquid when the corporate wanted a reimbursement shortly.
“Any time you are promised an 18 per cent return that’s offered as danger free, that’s only a pink flag,” he mentioned.
Celsius’s chapter submitting continues a tough interval for cryptocurrencies, and different high-profile platforms together with Babel Finance, Vauld and Voyager have run into bother in latest weeks.
Celsius’s own bankruptcy documents admit it made “what, in hindsight, proved to make certain poor asset deployment selections”.
Mr Mashinsky’s declaration additionally cites the high-profile “implosion” of cryptocurrency Luna and its TerraUSD stablecoin as accelerating the onset of a “crypto winter” and prompting an uptick in clients attempting to get their cash out — akin to a financial institution run.
The Celsius scenario additionally makes the dangers clear for Australian cryptocurrency buyers: abroad firms are topic to abroad guidelines.
Aaron Lane, a lawyer and senior analysis fellow within the RMIT Blockchain Innovation Hub, mentioned how a lot native buyers in the end recovered from Celsius was now within the arms of US courts, the place cryptocurrency bankruptcies have been a comparatively new phenomenon.
“That is one thing that buyers want to contemplate on the entrance finish … doing all your analysis and actually contemplating who controls the cryptocurrency that you just’re placing in,” he mentioned.
Each Dr Lane and Dr Harvey recommended Celsius’s scenario, in addition to the litany of different cryptocurrency collapses, was more likely to spur authorities regulation of the business.
This may increasingly embody whether or not cryptocurrency lenders like Celsius shall be compelled in future to abide by guidelines set for extra conventional monetary establishments, comparable to capital necessities to guard depositors.
“How can customers know that in the event that they’re placing cash into considered one of these platforms that they will get it again, or not less than get a proportion again?” Dr Lane mentioned.
Ms White says there is a sample in how cryptocurrency initiatives are allowed to function that may’t proceed.
“Crypto initiatives do no matter they need, promote nevertheless they need, run their companies with principally no transparency and no necessities for the way they’re dealing with their belongings, after which [regulators] simply watch for them to blow up,” she mentioned.
“We won’t afford to have carried out it so long as we now have. Persons are persevering with to get harm.”
*Title has been modified for privateness.

domain: news


text:
Brought to you by Boompa Productions, the Vancouverites that call themselves “music geeks” bring you their 6th and most recent album “Grey Eyes” released October 2010.
Fresh off the press, this indie pop album embraces orchestral sounds and features: clarinet, bass clarinets, trumpets, baritones, flugelhorns, tenor sax, bari sax and tuba with flute as a vocal accompaniment and beautiful touch.
Scott Walker puts his Bachelors in Music to practice through singing, writing and producing a unique album. The tracks fuse pop liveliness with orchestral varities that mesh jazz rifts with symphonic harmonies accompanied by the traditional use of a snare. The best part about it is that unlike other indie albums I have encountered, the vocals are audible and the lyrics genuine. Plus the album includes slight electronic mash-ups that are just subtle enough to not distress the pop-lover ears.
If you appreciate the uplifting effect music can have on making a bad day seem a bit better then you will certainly appreciate ‘Grey Eyes’ by the Salteens.
Visit their website the Salteens

domain: entertainment


text:
Smooth until creamy and set to one side. The keto diet is definitely worth all the hard work in the end. Virta Health recently showing patients could rapidly improve glycemic control through reductions in fasting blood glucose, HbA1c, and medication use after 10 weeks of treatment. You can make it in the oven if you wish. Place 12 cupcake moulds onto a baking tray. You may question some of the ingredients.
Set in the fridge to cool down. A Sample Ketogenic Meal Plan For 1 Week To help get you started, here is a sample ketogenic diet meal plan for one week:. Leave for about 20 minutes, while you work on the other part. The remaining 5 percent or so should come from carbohydrates. You can create muffins with 4. Once cooked, add the rest of the ingredients and mix. Is It Really Going to Be Worth All This? Find support groups and alternative recipes to avoid these pitfalls and setbacks.
Research has demonstrated that ketones prevent muscle catabolism. If you want something a little lighter on the stomach, consider some turkey mince or pork mince instead. I saw results immediately, and once I gained momentum there was no stopping me. Remember to flip to prevent one side burning! Top with salsa and sour cream, and some shredded cheese. You should be able to get 8-10 patties. So how do you know if the diet is working? Add your cauliflower into a very hot pan.
This ultimate fat burning mode is known as ketosis. The reduction in puts your body into a metabolic state called. If an individual is following a ketogenic diet strictly for therapeutic reasons, one may consider trying to achieve a deeper level of ketosis, but even those with a strict regimen may see only slight elevations in ketones due to rapid uptake into tissues. Chicken Tikka Masala Curries are popular dishes, especially a tikka masala. You can add in some sweetener if you find you need it in your muffins.
This should already be something you are fitting into your , but, try to get some extra exercise and go for a walk each day to help generally improve flu symptoms. Now add in the eggs and blend again. Just put in the oven on a medium heat for around 15 minutes. For more details on the weight loss effects of a ketogenic diet, read this article:. A simple sauce of butter, lemon juice, chopped garlic, and some salt and pepper will go a long way to enhancing the natural flavor of the salmon. You just need to substitute your rice for some cauliflower rice—and that is really simple and delicious to make. Spread the cream cheese over the top.
My refusal to try anything different was driving my family crazy too. How Do I Know If I am in Ketosis? Which sweeteners are best on ketogenic diet? Try some tomatoes, pickles, and more! Take it easy on your body and mind. The former is natural, while the latter only occurs in uncontrolled diabetes. Be sure to avoid sugary liquors and beer as well as sugar-laden mixers. Use this stuff to season your food, drinks, hell, shoot it like vodka. This article and website will be added to my resource list. You can also season your sandwich to taste.
Preheat the oven to 350. Soon after, total body water and glycogen levels will balance out. Oils and Fats , , butter and bacon fat are great for cooking and consuming. Once one is adapted, these products are excellent for achieving higher blood-ketone levels, which, in turn, can be beneficial for athletic and cognitive performance, energy production, and perhaps more effective therapeutic treatment. There are so many fabulous foods on the keto diet and so many delicious ways to prepare them that you almost forget about bread. Season and place in the oven. Preheat the oven to 350.
This is a complete change in lifestyle. I believe that kindness is king! However, it should be noted that as the body keto-adapts, hunger and appetite should become suppressed. Or worse-end up gaining weight. Place onto the cookie sheet and put into the fridge to cool completely. Nearly 1 in 10 adults in the U.
To maximize your chances of success with the keto diet, you need to remove as many triggers as you can. Remove and allow to cool before serving. However, the opinions expressed in each post are my own. This article was republished with permission. If you need to eat more or fewer calories per day, you can adjust accordingly by simply taking out or adding a bit more of the ingredients already included in a recipe. The inability to secrete insulin prevents ingested carbohydrates glucose from entering our insulin-dependent cells i. Benefit 2: Control Blood Sugar Most carbs you consume are broken down into sugar that enters the bloodstream.

domain: food


text:
“If Abe Lincoln was Jewish, he could have been Bar Mitzvah’d in our synagogue!”
That’s right. We’re that old…
Built in 1832, our Franklin based historic building originally housed the First Particular Baptist Church. As the town of Franklin grew and developed, the population began to include Jewish immigrants from Russia and other European countries.
In 1909, seventeen of these immigrants purchased a Torah and formed the Congregation Sons of Israel. They met in each other’s homes looking forward to the time when a suitable building could be obtained. This came in the form of a “gift” from the First Presbyterian Church, when their new brick church was dedicated. On March 3, 1919, the congregation purchased the church for $100 and transformed it into an Orthodox synagogue, thus becoming the first synagogue in Sussex County.
In 1975, the Congregation Sons of Israel, merged with members of Temple Shalom of Sussex County and in 2015, after several years of discussion, Temple Shalom merged with The Jewish Center of Sussex County to create B’nai Shalom of Sussex County.
Today, our current membership reflects many people working hard to continue what was started nearly one hundred years ago. The B’nai Shalom Congregation is going strong and growing with a thriving school and 2 locations! We are a very active and viable part of the community. B’nai Shalom continues to proudly serve the growing Jewish community of Sussex County.
Isn’t it time for you and your family to become part of our growing history?

domain: history


text:
Party affiliation: Democrat
Personal book service Charles Scribners Sons, New York City, 1926-1927. Copywriter The MacMillian Company, 1928-1932, The Century Company, New York City, 1932-1934. Managing editor The American Girl Magazine, 1934-1942.
Publicity writer The Shelton Looms, 1934.
- Really RELAXING Colouring Book 5: Flights Of Fancy: A Winged Journey Through Pattern and Colour (Really RELAXING Colouring Books) (Volume 5)
- Really RELAXING Colouring Book 5: Flights Of Fancy - A Winged Journey Through Pattern and Colour is a beautiful and relaxing creative colouring book for all ages ! Switch off, unwind, and unleash your inner creativity as you lose yourself in the flow of colouring in these stunning patterns and designs.
- The Etruscans;: An unsolved mystery,
- Describes the civilization that flourished on the Italian peninsula some 500 years before Christ.
Born June 29, 1904
1926 - 1927
1928 - 1932
1932 - 1934
1934 - 1942

domain: hobby


text:
Lost in the first round in six games
Good news: you won more playoff games this season than the Pacers have won in the last four seasons games. Bad news: you only won two games in the first round and were unable to handle Giannis in a first-round series against the Milwaukee Bucks. You still feel pretty good about this group with so many young pieces but you wonder what their ceiling is.
Want to try again? Click here.

domain: game


text:
Chocolate Lab Puppies For Adoption In Illinois
Chocolate labrador retriever puppies for sale!the chocolate lab has a sweet nature and loves to play.
Chocolate lab puppies for adoption in illinois. With their patience, loyalty, and energy, labs are a. Chocolate lab dogs and puppies available for adoption near charlotte, jacksonville, and hickory! Born 4/4/2021 ready for his forever home memorial day weekend (8.
Because chocolate is a popular labrador retriever color but a recessive gene, some breeders use poor breeding and genetic practices to try and have more chocolate puppies. No cats please kid compatibility: We have 1 chocolate male lab puppy looking for his forever home.
Still available are chocolate males and females and one yellow female. We are a labrador retriever breeder in illinois and have black and yellow lab puppies for sale in illinois. Chocolate lab puppies for adoption 2021.
Will be ready for new homes around june 20th. We're looking for our adorable chocolate lab puppies a new families. All of our chocolate labrador puppies are vaccinated for their age and wormed several times prior to their new homes.
A complete list of all chocolate lab rescue groups located in north carolina and across the usa! Northwoods chocolate labs is located in northern illinois near rockford. We've got their parents on the location.
Silver lab rescue and labrador retriever adoption in 2021 silver lab rescue and its adoption procedure is very simple and easy. They're going out on a daily basis, and they were great at night when we kept them in our kitchen. Louis for sale are loved unconditionally from the minute they are born up until the day they join their new families.
- Clumber Spaniel Puppies For Sale Nc
- Cockapoo Puppies For Sale Virginia
- Clavamox For Cats Uti Dosage
- Chocolate Lab Puppies For Adoption In Michigan
- Cockapoo Puppies For Sale Virginia Water
- Clavamox For Cats Amazon
- Civet Cat Coffee Philippines
- Clumber Spaniel Puppies For Sale Ohio
- Chocolate Labrador Retriever Puppies For Sale In Pa
- Chinese New Year 2020 Holidays
- Cockapoo Dogs For Sale In Nj
- Clavamox For Cats Dosage
- Chocolate Lab Puppies For Adoption In Nc
- Civet Cat Meaning In Hindi
- Cockapoo Puppies For Sale Near Nj
- Christmas Stuffed Animals Walmart
- Chocolate Havanese Puppies Texas
- Cockapoo Puppies For Sale In South Jersey
- Chocolate Havanese Puppies For Sale Florida
- Chocolate Labrador Puppies For Sale In Southern California

domain: pet


Work by UMass Amherst physicists Andrea Pocar, Laura Cadonati and doctoral student Keith Otis, with other researchers on the Borexino experiment who reported this year that they accomplished the first detection of neutrinos from the main nuclear reaction powering the sun, has been named one of the “Top Ten Breakthroughs of 2014” by editors and reporters at Physics World magazine.
Three doctoral students at UMass Amherst have received Eugene M. Isenberg Scholar Awards. The students, Yueran Zhuo and David Agogo from the Isenberg School of Management’s operations and information management department, and Cole Fitzpatrick from the College of Engineering’s civil and environmental engineering department, each received $10,000.
The UMass Doo Wop Shop, a 10-member, male a cappella group, will perform at Radio City Music Hall in New York City on Thursday, Dec. 18. The group will perform a selection of holiday songs prior to the 8 p.m. performance of the Radio City Christmas Spectacular.
According to the group’s...
Students Allison Masley, Shayna Nolan, Curtis Owen, D’Andre Quinerly and Amanda Rutherford are the recipients of the fall 2014 Rising Researcher award. Rising Researchers are promising undergraduates whose leadership and accomplishments demonstrate excellence in their chosen field.
The New England Chapter of the American College of Sports Medicine (NEACSM) awarded kinesiology doctoral candidate Amanda Hickey its David N. Camaione doctoral student award during the group’s annual conference held Nov. 13-14 in Providence.
The criteria for the $1,000 award are academic...
Christo Brand, a former prison guard at South Africa’s Robben Island and author of “Mandela: My Prisoner, My Friend,” will speak at UMass Amherst on Tuesday, Dec. 2 at 1 p.m. at the Commonwealth Honors College Events Hall.
Barbara J. Love, professor emeritus of social justice education, will be the guest speaker at the closing reception for the community exhibit “Representations of Oppression and Liberation” on Friday, Nov. 21 from 3-5 p.m. in the Student Union Art Gallery.
A scholar on issues of...


text:
On numerous occasions, Moyes has said that he wants to take West Ham as high as possible but a challenge for continental football next season would be “a humongous step.” In the aftermath of his side’s most recent win, a 3-0 victory over Sheffield United,
David Moyes said: “Pearcey [Stuart Pearce] mentioned to me before the game that we have five games before the first of April. Obviously, we are still in February so at the end of those five games if we get into the last month or two of the season then it might hot up but we can’t really be talking this way. It nearly feels a bit uneasy. I don’t want to be negative in any way but the teams around us are super teams, so let’s be fair we are up against some top top talent, top teams and we are going to have to play incredibly well to be there.”
Donate to Premier League Museum
Marcus Rashford will put his feet up when England’s Euro 2020 adventure comes to...
Former West Ham striker and potential transfer target Marko Arnautovic has been handed a...
Aaron Ramsdale says Harry Kane and Jordan Henderson wasted no time in making him...
But he is “really encouraged” by progress made since the club stepped up their...
/ 18 hours ago
#PLStories- #BenWhite to Arsenal latest as Brighton reject £40m bid for England defender #BHAFC #ARSENALFC
With David Luiz leaving the club, the Gunners are eyeing a new centre-back and...
Leaderboard is empty


text:
The focus of this lesson is the Robert Gould Shaw and the Massachusetts 54th Regiment Memorial by Augustus Saint-Gaudens. Students will put themselves in the shoes of the men of the Massachusetts 54th Regiment as they read, write, pose, and then create a comic strip about these American heroes.
Through the use of maps and original documents, this lesson will focus on the key battles of the Civil War, Gettysburg and Vicksburg and show how the battles contributed to its outcome. It will also examine the "total war" strategy of General Sherman, and the role of naval warfare in bringing about a Union victory.
In this lesson students learn how Birth of a Nation reflected and influenced racial attitudes, and they analyze and evaluate the efforts of the NAACP to prohibit showing of the film.
The Red Badge of Courage’s success reflects the birth of a modern sensibility; today we feel something is true when it looks like the sort of thing we see in newspapers or on television news.
Students develop a foundation on which to understand the basic disagreements between North and South.
Clues to Walt Whitman's effort to create a new and distinctly American form of verse may be found in his Notebooks, now available online from the American Memory Collection. In an entry to be examined in this lesson, Whitman indicated that he wanted his poetry to explore important ideas of a universal scope (as in the European tradition), but in authentic American situations and settings using specific details with direct appeal to the senses.
Sometimes, people will fight to keep someone else from being treated poorly. Disagreement over slavery was central to the conflict between the North and the South. The nation was deeply divided.
Students demonstrate their knowledge of life before the Civil War, with an emphasis on differences between the North and South.
What was life like for women in the first half of the 19th century in America? What influence did women have in shaping the attitudes towards slavery? Towards women's suffrage?
In The Red Badge of Courage, Stephen Crane presents war through the eyes —and thoughts —of one soldier. The narrative’s altered point of view and stylistic innovations enable a heightened sense of realism while setting the work apart from war stories written essentially as tributes or propaganda.


Buzzing Nigerian singer, Ahmed Ololade, popularly known as Asake, has gotten tongues wagging with amusing reactions online after a trending video clip of a man who bares a semblance with him was spotted being prayed for by Islamic clerics.
In the clip, the man said to be Asake, is seen sitting in front of an Alfa who placed his hands on his head as he recited the Quran and prayed for him. Other Islamic clerics, who were also present in the room, prayed along with the lead Muslim cleric.
The video has sparked a myriad of reactions from netizens who shared their two cent on the secular singer’s decision to receive prayers from Islamic clerics.
While some expressed surprise that the ‘Sungba’ crooner is religious, others said they didn’t know he is a Muslim.
Some others opined that Asake was seeking spiritual help because of his new competition in the music game, Seyi Vibez.
It’s no news that Seyi Vibez is currently rocking the music industry. Even though he has been making music for years, he recently received huge acceptance from Nigerian music lovers after he released two albums in quick succession. Coincidentally, Seyi Vibez and Asake’s voice and style of music are painfully similar.
See video and some comments below:
Discussion about this post


text:
Critical Analysis: Aerie Pharmaceuticals (AERI) versus The Competition
Aerie Pharmaceuticals (NASDAQ: AERI) is one of 283 publicly-traded companies in the “Bio Therapeutic Drugs” industry, but how does it contrast to its competitors? We will compare Aerie Pharmaceuticals to related businesses based on the strength of its dividends, earnings, profitability, valuation, analyst recommendations, institutional ownership and risk.
Institutional & Insider Ownership
95.7% of Aerie Pharmaceuticals shares are owned by institutional investors. Comparatively, 49.9% of shares of all “Bio Therapeutic Drugs” companies are owned by institutional investors. 9.4% of Aerie Pharmaceuticals shares are owned by insiders. Comparatively, 17.2% of shares of all “Bio Therapeutic Drugs” companies are owned by insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock will outperform the market over the long term.
Risk & Volatility
Aerie Pharmaceuticals has a beta of 1.14, indicating that its stock price is 14% more volatile than the S&P 500. Comparatively, Aerie Pharmaceuticals’ competitors have a beta of 1.28, indicating that their average stock price is 28% more volatile than the S&P 500.
Valuation & Earnings
This table compares Aerie Pharmaceuticals and its competitors revenue, earnings per share (EPS) and valuation.
|Gross Revenue||NetIncome||Price/Earnings Ratio|
|Aerie Pharmaceuticals||N/A||-$99.05 million||-17.52|
|Aerie Pharmaceuticals Competitors||$286.20 million||$34.74 million||131.06|
Aerie Pharmaceuticals’ competitors have higher revenue and earnings than Aerie Pharmaceuticals. Aerie Pharmaceuticals is trading at a lower price-to-earnings ratio than its competitors, indicating that it is currently more affordable than other companies in its industry.
This table compares Aerie Pharmaceuticals and its competitors’ net margins, return on equity and return on assets.
|Net Margins||Return on Equity||Return on Assets|
|Aerie Pharmaceuticals Competitors||-5,616.95%||-481.94%||-40.11%|
This is a summary of recent ratings and target prices for Aerie Pharmaceuticals and its competitors, as provided by MarketBeat.
|Sell Ratings||Hold Ratings||Buy Ratings||Strong Buy Ratings||Rating Score|
|Aerie Pharmaceuticals Competitors||804||3164||11461||230||2.71|
Aerie Pharmaceuticals currently has a consensus target price of $71.85, suggesting a potential upside of 22.40%. As a group, “Bio Therapeutic Drugs” companies have a potential upside of 44.21%. Given Aerie Pharmaceuticals’ competitors higher probable upside, analysts clearly believe Aerie Pharmaceuticals has less favorable growth aspects than its competitors.
Aerie Pharmaceuticals competitors beat Aerie Pharmaceuticals on 7 of the 12 factors compared.
Aerie Pharmaceuticals Company Profile
Aerie Pharmaceuticals, Inc. is a clinical-stage pharmaceutical company. The Company is engaged in the discovery, development and commercialization of therapies for the treatment of patients with glaucoma and other diseases of the eye. The Company’s product candidates include Rhopressa (netarsudil ophthalmic solution) 0.02% (Rhopressa), and Roclatan (netarsudil/latanoprost ophthalmic solution) 0.02%/0.005% (Roclatan). The Company’s product candidates are designed to lower intraocular pressure (IOP) in patients with open-angle glaucoma and ocular hypertension. Its Rhopressa is a once-daily eye drop. Rhopressa inhibits Rho kinase (ROCK), and the norepinephrine transporter (NET), which are both biochemical targets for lowering IOP. Its Roclatan is a once-daily, fixed-dose combination of Rhopressa and latanoprost, which is a prescribed drug for the treatment of patients with open-angle glaucoma. The Company is engaged in conducting Phase III clinical trial for Roclatan.
Receive News & Stock Ratings for Aerie Pharmaceuticals Inc. Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Aerie Pharmaceuticals Inc. and related stocks with our FREE daily email newsletter.

domain: finance


text:
Generali People Strategy, GPeople 2021, was unveiled in 2018 to promote the diversity, talents and abilities of the employees. Generali Group invests in its people thru promoting healthy and safe working conditions, work-life balance, training and etc. 2020 has brought out of the ordinary challenges to companies as they struggle to survive the effects of the pandemic. However, in Generali, it has highlighted the ongoing efforts under the GPeople 2021.
Generali Philippines, thru its Chief Human Resources Officer Lorna Pabelico, was invited to tell its story on how it has adapted during the long days of community lockdown and work from home operations in the recently published book, The 50: HR Leaders Reimagining the Filipino Organization.
In this trying times, Generali Philippines remains committed to our people thru providing sustainable programs on Mental Health, Employee Engagement among others. We strongly believe that our people are an important foundation in changing our customers’ lives and stay true to becoming their Lifetime Partner.The 50 book is a compilation of best practices from different organizations, as told by Human Resources Leaders. Find inspiration on resiliency amidst the pandemic. You may purchase the book here: https://bit.ly/39fyxot.


text:
Making macarons has become a little bit of free therapy for me. Methodically measuring out ingredients, piping, baking, filling… it is comforting and relaxing. I find the same type of satisfaction when making lemon curd. Sure, you can buy it already made at the store. But making it at home means you can probably make a lot of it very cheaply. And there is something about separating egg yolks and whisking that mixture until it thickens and becomes unctuous and delicious that simply makes me happy. All for the price of sugar, eggs, butter, and lemons. And lemon curd is versatile, you can make lemon meringue tarts, lemon ice cream, cookies filled with lemon curd, serve it along some pound cake, fill cupcakes with it, and of course, fill macarons with it.
I haven’t made macarons for the blog since October, so I was excited to participate in the MacAttack 15 Challenge. Jamie & Deeba of Mactweets challenged us to enjoy the comfort of a favorite dessert, something that would inspire us to create a macaron. So my comforting dessert definitely is lemon curd. The best part about making lemon curd is that you have egg whites left to make macarons.
Right now it is still cold, and there are snow flakes falling every other week. I wanted to make something with tropical flavors, that reminded me of the beach and the sun. Finally the idea came to me: passion fruit curd. I easily found passion fruit concentrate at a grocery store that carries a lot of Latin American products. If you find all natural frozen concentrate, that is best. But you can also use the bottled kind (sadly not all natural) but it works equally well here. Just make sure you pick up concentrate and not juice or nectar.
Recipe for macaron shells here.
Passion Fruit Filling
8 oz white chocolate
3 ounces heavy cream
4 oz passion fruit curd
1 to 2 tablespoons passion fruit concentrate
1. In a small saucepan, bring heavy cream to a boil.
2. Melt chocolate over a double boiler.
3. Pour cream in two additions over the white chocolate. Whisk until well incorporated.
4. Whisk in passion fruit curd. Whisk in 1 tablespoon passion fruit concentrate. Taste and add 1 more tablespoon if desired.
5. Refrigerate until ready to use.
Passion Fruit Curd
(recipe from Martha Stewart)
• 1 cup sugar
• ½ cup passion fruit concentrate
• 6 large egg yolks
• 4 tablespoons unsalted butter, diced
1. In a medium saucepan, place the sugar, passion fruit concentrate and egg yolks. Cook over medium heat, whisking constantly until the mixture thickens. This should take about 15 minutes. Turn heat off, and add the butter pieces one by one until all the butter is incorporated. Let cool and refrigerate until ready to use it. Makes about 2 cups.
Finally, I have some news to share with you. The lovely Mayi from the beautiful and inspiring Heartmade Blog asked me to write a special recipe blog post for her readers. Heartmade is all about creativity and inspiration. I was extremely flattered that she would ask me and wanted to create something extra special. Hopefully I will be working with Heartmade throughout the year, contributing fun and delicious kitchen projects. So here is a little preview of the yummy passion fruit meringue cupcakes I made.
Please stop by Heartmade and check it out. After all, if you decide to make the passion fruit curd, you will have enough for macarons and cupcakes and I have no doubt that you will love all the inspirational content at Heartmade!
Hola check La Prensa site en los suplementos A LA MESA y salen los Macarons de un restaurante francés la verdad
las fotos y la receta (explicaciones etc.) no le llegan a los tuyos. Vuelvo y repito los tuyos son fabulosos!
I love your pictures!
Very cool to see another DC-area MacTweeter! I love macaron fillings that lean towards tart; they’re such a good contrast to the sweet shells. Your pictures are beautiful and the feet are perfect.
Your macarons are brilliant. I find them entirely charming, perfect in every frame, and very inspired. congratulations on being invited to write for Mayi. That does look like a wonderful recipe to contribute. Thank you for joining us at MacTweets Cecilia.
What beautiful yellow macarons. Just looking at them puts me in a sunny mood. The cupcakes are lovely as well.
those cookies look very good. hopefully i will taste them someday.
If this is a beauty pageant, your macaron wins Miss Universe. I’ve never said that to any macaron. Ever.
These passion fruit macarons really look amazing and I love the photos that are displayed. Very nice post.
Your macarons are flawless and beautiful. Where would I find something like passion fruit concentrate? Is that a refrigerated item? A canned item? Please let me know. I LOVE passionfruit but don’t know what section of the store I would find that in.
Gio–Mil gracias por tus lindas palabras. Besos!
Laura–Thank you for stopping by!
Victoria–Yeah, I always lean toward tart fillings. Love the contrast!
Deeba–Thank you so much for your kind comments. You are such a sweetheart!
Lora–I was really going for sunny yellow! You can’t really see it in the picture but the passion fruit curd was such a vibrant yellow color.
Annapet–Thanks! Yay, I will have to rename these Miss Universe macarons!
Babygirl–Thank you hon!
Fifteenspatulas–It depends, you can find it in the freezer section, or in the Latin American food section. This time the one I bought came in a bottle. It will say Maracuya or Parcha.
That macaroons look perfect, Yummy!
Oh dear these look just amazing! I should really get myself together and make my own macarons once! As much as i was spoiled with them in Brussels, now in Budapest they are impossible to buy:(
Passionfruit is also one of my favourites, these i guess just taste delicious!
Such a happy-looking, delicious-tasting macaron! Love the passion fruit flavoring all around.
Pretty and perfect Cecilia! I love making my own curd too, and would vouch for the yumminess of passionfruit. I’m lucky that passionfruit grows quite easily in Australia, in fact I have a vine in my tiny garden but so far no fruit yet 🙂
These look delightful, I so love passionfruit flavoured things. Lovely looking macs!
stunning. love the first photo and the one w/the brown & pink napkin.
Your macarons look perfect and just like the ones I enjoyed in when I vacationed in Paris.


text:
Alexia Lalande is an all-purpose artist living in Hartford, Connecticut. She obtained her BFA in Studio Art at the University of Connecticut, and her MAT at the Massachusetts College of Art & Design. She currently teaches graphic design and screen-printing in the Hartford Public School system. Her artistic pursuits include a variety of media, mainly mixed media illustration, printmaking and animation. She is a resident artist at The Dirt Salon in Hartford.
Studio a-lala values a distinctly rough edge. Every design involves a lot of research and experimentation to the end of creating something unique and fresh for every client.
...but super sensitive to client's needs and priorities. Contact me today for a free consultation!

domain: artistic


text:
If you’ve never tried beef chorizo before, then place an order for our “Guerra’s Brand” Inc. beef option! Carefully packed with savory ingredients and succulent beef, you’ll be wanting more after each serving!
*Contains 100% natural ingredients, no additives, no preservatives, and no artificial colors.
|Dimensions||2 × 2 × 2 in|
Only logged in customers who have purchased this product may leave a review.


text:
Many politicians, activists and academics have long characterized the criminal justice system as biased against Black and Brown people, with the catchall term “Brown” usually referring to Hispanics. But the latest data shows that Hispanics’ experience of criminal justice and law enforcement is becoming increasingly similar to that of Whites, not Blacks. This little-noticed trend has major implications for the future of criminal justice reform.
The Hispanic experience in jail looks more like the White one now
March 10, 2023

domain: sociology


text:
Lockheed Martin Corp. called an end to its year-long effort to acquire Aerojet Rocketdyne Holdings in a $4.4-billion deal, after the U.S. Federal Trade Commission sued to block the transaction in late January. FTC claimed that Lockheed would use its control of Aerojet – a supplier of advanced power, propulsion, and armament systems that are critical components of missile systems – to undercut the competitiveness of other defense contractors (e.g., Boeing, Northrop Grumman, Raytheon Technologies), and consolidate several national defense/security markets.
"Our planned acquisition of Aerojet Rocketdyne would have benefitted the entire industry through greater efficiency, speed, and significant cost reductions for the U.S. government," said Lockheed chairman James Taiclet maintained in a statement. "However, we determined that in light of the FTC's actions, terminating the transaction is in the best interest of our stakeholders.”
When Lockheed announced a takeover agreement with Aerojet Rocketdyne in December 2020 analysts described it as an effort by Lockheed to remain competitive with SpaceX and others for U.S. government contracts.
Later, it was suggested that Aerojet would provide propulsion and power systems that would be critical to Lockheed’s hypersonic weapons developments.
"Moving forward, we will maintain our focus on the most effective use of capital with the highest return on investment, including our ongoing commitment to return value to shareholders,” Taiclet pledged. “We remain confident in our company's strong foundation and growth potential as several exciting projects enter production. hy


Hach Ultra says that the development of the Orbisphere A1100, capable for use in either process monitoring or laboratory analysis, can reduce sensor cleaning and maintenance time to less than three minutes. Accurately measuring oxygen during production is critical for taste and shelf life, with the latest development particularly suited for high output manufacturing where the downtime required for cleaning can prove costly. Rapid sensor refurbishment is made possible due to the inclusion of the group's patented recharge cartridge, which the company claims helps ensure that no technical experience or additional chemicals are needed for cleaning. Once maintenance has been completed, the technology's design makes use of a smart chip, which stores calibration parameters that once set in a laboratory, can allow the sensor to be plugged back into a production line, according to Hach Ultra. The sensor is made from a robust stainless steel material, designed to protect the device during extremely demanding applications, including high pressure cleaning in place (CIP) of up to 100 bar, says the manufacturer. Hach Ultra claims that the latest development in its Orbisphere sensor range can ensure an accurate and swift detection of any changes in oxygen during processing.


text:
Jerry Falwell, the brimstone-and-treacle preacher who died this week , occupied an especially honoured place in the demonology of America’s critics.
He was, let’s be honest, an easy target, the very avatar of almost everything that alarms people about the modern United States. The received version of recent American history will attest that Falwell played a central part in the nation’s rightward lurch towards intolerance and bigotry in the past 30 years, that he was one of the cross-and-microphone-wielding revolutionaries behind the theocratic overthrow of liberal, tolerant American government.
He played his assigned role brilliantly. He could inspire contempt and fear


text:
- Subscribe NowLimited Time Offer
Charlotte City Council approves Mecklenburg Mill project funding
Send this to a friend
(Page 2 of 2)
And Nixon noted that NoDa, unlike other neighborhoods, wants affordable housing. Residents behind her as she spoke waived signs reading "YIMBY" -- meaning, "Yes In My Back Yard."
The added mill funding will be paid with carried-over funds from a federal Community Development Block Grant program. The city has about $4.6 million available because of savings on projects from the past year.
Mayfield noted that the city’s contribution of $1.25 million is essentially returning the amount the developer paid the city to acquire the property.
And Councilman Michael Barnes added that the RFP put out by the city to solicit buyers would have been very different had council known the property would be given away for free. However, Barnes joined eight other council members in support of the project, most of whom voiced concerns over historic preservation.
Mayor Anthony Foxx started the conservation conversation, calling on council to support the project out of concern that the city has lost so much historic property. Foxx says he had "a moment" after watching the demolition of the Virginia Paper Co. plant, which was torn down to make way for an uptown ballpark.
Councilwoman Beth Pickering, in her support of the Mecklenburg Mill project, issued a challenge to the council, calling for a vow that the Virginia Paper property be the last historic building town down in Charlotte.
Susan Stabley covers growth, the environment and residential real estate for the Charlotte Business Journal.
- Most popular
- Here’s where Charlotte’s wealth is (INTERACTIVE MAP)
- Faith groups line up in opposition to Bank of America's CEO/chairman
- Sonic Automotive's bold shift to the future
- Charlotte Checkers eye return to Bojangles' Coliseum
- 7 things you must know about Sonic Automotive's bold transformation
- Crescent, Levine both plan apartment-hotel combos, a first for city
- New stores open in Charlotte's SouthPark mall
- Charlotte-based Tresata CEO: 'We can be a billion-dollar company'
- Protests planned in Charlotte after Ferguson decision
- American Airlines CEO talks bag fees, possible HQ move, labor talks
Sign up to receive Charlotte Business Journal's Morning Edition and Afternoon Edition newsletters and breaking news alerts.
Work For: ChannelAdvisor ChannelAdvisor | Morrisville, NC
Audience Development Director Charlotte Business Journal | Charlotte, NC
Local Account Manager The Business Journals | Charlotte, NC
Full-Time Teller Piedmont Advantage Credit Union | Charlotte, NC
Talent Acquisition Business Partner WESTMED Practice Partners | Charlotte, NC


text:
New language discovered in Australia, only spoken by 350 people
From: Daily Telegraph News
It’s spoken only by a few hundred people living in a tiny desert community, and almost exclusively by those under the age of 35.
But the discovery of a new language in remote Australia is causing a ripple of excitement among linguists around the world.
Lajamanu, with a population of around 850, lies on the northern fringe of the Tanami Desert, 870 kilometres south of Darwin and 560kms southwest of Katherine by road.
It is one of the Northern Territory’s most westerly communities and its original language, Warlpiri, is spoken by about 6000 people in the region.
Carmel O’Shannesssy, a linguist from the University of Michigan, began visiting the town to study local young people’s speech more than a decade ago.
Lajamanu has no entirely paved roads and during the wet season it can be cut off.
A community-managed airline lands a plane on the town’s dirt airstrip twice a week carrying mail, and once a week a truck brings in supplies to stock Lajamanu’s one village store.
All residents speak traditional "strong" Warlpiri and some speak "Kriol", an English-based creole developed in the late 19th century and widely spoken by indigenous Australians in the Northern Territory and Western Australia.
Around 350 young locals speak the new language documented by Ms O’Shannessy, called "Light Warlpiri".
The language is a complex mix of English, Kriol and Warlpiri, but has a verbal system closer to Kriol and English.
Documented in the journal Language, Light Warlpiri differs from its indigenous origins by mixing in English sentence structure.
"The striking thing about Light Warlpiri is that most of the verbs come from English or Kriol, but most of the other grammatical elements in the sentence come from Warlpiri," Ms O’Shannessy told LiveScience.
In English, the order of words in a sentence generally indicates the grammatical relationship between the subjects and objects of a verb.
In traditional Warlpiri, words can be placed in any order, and grammatical interpretations are based on suffixes that are attached to the nouns.
"In Light Warlpiri, you have one part of the language that mostly comes from English and Kriol, but the other grammatical part, the suffixing, comes from Warlpiri," Ms O’Shannessy said.
Read the full article at: dailytelegraph.com.au
Social Media Images Form a New Language Online
Fossil words and how language changes
Prairie dogs’ language decoded by scientists
Elephants Communicate in Sophisticated Sign Language
Before Babel: In search of the first language
For 40 Years, This Russian Family Was Cut Off From All Human Contact, Unaware of World War II
Coober Pedy – Australia’s Underground Town
Religious sect found after living underground in Russia for nearly a decade
African Coins Found in Australia Thought to Be 1,000 Years Old: May Rewrite History
Latest News from our Front Page
British scientists granted permission to genetically modify human embryos
The Francis Crick institute will genetically edit the leftover embryos from from IVF clinics
British scientists have been granted permission to genetically modify human embryos by the fertility regulator.
The scientists want to deactivate genes in leftover embryos from IVF clinics to see if it hinders development.
It will only be the second time in the world that such a procedure has ...
Conspiracy Guy - Flat Earth
The Conspiracy Guy takes on some ballers.
Source: Joy Camp
Nonwhite Invasion Crashes Swedish IQ
More than one-third of all school pupils in Sweden are unable to complete the most basic of academic standards or pass any exams, a new report has revealed—the direct result of the mass nonwhite invasion of that country and the subsequent flooding of its school system by hordes of low IQ Third Worlders.
According to a report in the educationist’s Lärarnas ...
German left-wing politician gang-raped by immigrants is "unbelievably sorry" for being raped and for "racist society"
A 24-year-old woman, and speaker for the German “Left Youth” party was gang-raped by 3 immigrants on January the 27th, in the city of Mannheim.
German police are still carrying out their investigation, but on January the 30th, the woman, wrote an apology on Facebook, addressed to the immigrants who allegedly raped her. Here’s a few excerpts from the now-deleted post:
Russia warns of 'new world war' starting in Syria
Foreign and defence ministers of the leading international states are meeting in Munich and Brussels following the collapse of the latest round of peace talks
Foreign and defence ministers of the leading international states backing different factions in the war-torn country met in separate meetings in Munich and Brussels following the collapse of the latest round of peace talks.
Both Russia and ...
|More News » |


text:
Lafayette Weather – Santa Should Be Gone Before Storms Arrive
A lot of us will be keeping our eyes on the sky tonight, Dave Baker and Rob Perillo will be watching the skies for a different reason. While we are looking for a sleigh and reindeer, Rob and Dave will be watching for severe weather approaching the Lafayette area.
The storms prediction center has given much of Acadiana a slight risk of severe weather. The area between Alexandria, Louisiana and Jackson, Mississippi has a moderate risk of heavy storms. This means the probability is quite high that the will be under at least a severe thunderstorm watch for tomorrow morning. This might be upgraded to a tornado watch if conditions change.
Travelers can expect mostly dry conditions for travel today. Those heading west on Christmas Day might run into some rain, thunderstorms, and the potential of flooding.
Rains will be in the Acadiana area from mid morning Christmas Day through mid afternoon tomorrow.


text:
Taking the iconic melody of the theme music of THE NFL ON CBS, the 2012 Grammy Award-winning ReBirth Brass Band added its signature Touch of heavy funk to record and create new music to be featured in various bumpers, billboards and animation beds throughout the day of CBS Sports' coverage of Super Bowl XLVII on Sunday, Feb. 3.
Upon recording the music in New Orleans, VonLichten from ES Posthumus remixed the track to embrace Rebirth's Style of upholding the tradition of brass bands while at the same time incorporating THE NFL on CBS theme.
In addition, CBS Sports Network is using the track for their shows Super Bowl LIVE and INSIDE THE Super Bowl throughout its coverage during Super Bowl week. CBSSports.com is also using it for their EYE ON FOOTBALL LIVE AT JACKSON SQUARE packaging and other shows.
More Articles by This Author...
Photo Flash: Saturday Intermission Pics, May 25 - Cast of KINKY BOOTS Braves the Rain, Holland Taylor, & More!
VIDEO: Joss Whedon Chats THE AVENGERS 2 on LATE NIGHT WITH JIMMY FALLON
Rihanna for River Island Summer Collection Lands May 25th
Exclusive InDepth InterView Audra McDonald Talks GO BACK HOME Album & PBS Special, MARLENE DIETRICH'S ABC, Upcoming Projects & More
Donkey Kong Country Returns is Back and Optimized for Portable Play
BWW Blog: Leah Edwards - Practice. Perform. Repeat
BWW Reviews: Millepied, Wheeldon and Martins - A Mixed Bag for City Ballet
Jay Leno Hosts Magical Evening to Celebrate Partnership for Cancer Care


text:
- Shopping Bag ( 0 items )
From Barnes & NobleDiscover Great New Writers
Haunted by his childhood memories, an aging Anglican priest shares magical tales of life in the Canadian wilds.
The woods surrounding the fictional town of Sawgamet in the cold, snowy upper reaches of Canada hold many secrets. It is where shape-shifters, giant golden caribou, singing dogs, and all manner of mythical beings like "adlets," "wehtikos," and "qallupilluits" roam freely in the densely packed forests. To this landscape, Stephen, an Anglican minister, returns with his family during World War II to his childhood birthplace, once a prosperous gold rush and lumber town now fallen on hard times. He arrives to take over the parish and to see his dying mother. As he settles in and keeps vigil by his mother's bedside, he remembers his early years and the stories about his family's history, of his pioneering grandparents, of the bitter winters that try men's souls, and of the love that outlives death. If he wants to pass on the stories to his children, he has to come to terms with a past that is haunted by encounters with ghostly visions of loved ones, terrifying monsters, and ethereal creatures.
Zentner's luminous prose successfully conjures magical realism in the wilderness of northern Canada, at once evoking a harsh and unforgiving environment while spinning a soul-stirring tale about loss, love, and the power of believing in miracles. With its seamless blending of the natural and supernatural that is reminiscent of South American writers Borges and García Márquez, Touch is storytelling at its spellbinding best.

domain: library


text:
Slightly over 25% of the season has already been cancelled. When they craft a new CBA it better be for longer than 7 years because this is getting fucking ridiculous. If these two babies would have began this process with honest discussions and started the process during the summer, then fans wouldn't have to suffer through cancellations. Oh, but they are trying to do this for the fans. Fuck you all.
Here are some of Bill Daly's bullshit comments about this latest cancellations.
"We acknowledge and accept that there is joint responsibility in collective bargaining and, though we are profoundly disappointed that a new agreement has not been attained to this point, we remain committed to achieving an agreement that is fair for the Players and the Clubs -- one that will be good for the game and our fans."
I hope both sides remember these cancellations when the revenues drop significantly due to decreased casual fan support. Don't go raising ticket prices and blaming us for your dickshit actions.


text:
THE ANNUAL MASS to celebrate the foundation of Celtic Football Club and to commemorate Brother Walfrid will take place in St Mary’s Church, Abercromy Street in Glasgow on Sunday 6 November at 3:00PM.
Celtic were founded in St Mary’s Church Hall on September 6, 1887 as part of a charitable drive to put food into the bellies of hungry children in the East End of Glasgow. Brother Walfrid stated that “a football club will be formed for the maintenance of dinner tables for the children and unemployed.”
That was the beginning of the road to Lisbon and has led us to where we are today with such a great club to support. We are Celtic Football Club.
In the late 19th century the money raised went to provide thousands of meals for the hungry children of the East End of Glasgow.
Those who could afford it paid 1d (one old penny); if the child brought their own bread, the meal cost 1/2d; if family couldn’t afford anything, the meal was free.
This was a massive logistical task to provide the meals, but it also brought the children into education.
Yet now, 129 years later, the Celtic Family are still proud of their charitable roots; yesterday Celtic Football Club donated £10,000 to kick off the Celtic Foundation’s 2016 Christmas Appeal; recently the Green Brigade helped raise over £170,000 for charities in Palestine.
CQN itself recently continued that self-same founding principle by donating over £6,900 to Mary’s Meals who are providing food and education for poor, hungry children all over the world.
As with our great Club, the Mass is open to people of all faiths and none.
The Mass is a celebration of the spiritual, charitable and cultural foundation of Celtic Football Club. It is a great occasion and an opportunity to get together and celebrate the birth of a wonderful institution.
There is also the chance to see Peter Howison’s magnificent portrait of Brother Walfrid (which some of you will recall was proudly displayed at CQN 11 at the Kerrydale Suite last year) and the mosaic commissioned for the 125th anniversary of the Club.
Refreshments will be served after the Mass which celebrates the foundation of Celtic Football Club and commemorates Brother Walfrid. We hope to see you there at St Mary’s Church, Abercromy Street in Glasgow on Sunday 6 November at 3:00PM.
For more reading on the foundation of Celtic Football Club we strongly recommend the brilliant book, Celtic The Early Years by Brendan Sweeney which is available from www.cqnbookstore.com


Road construction in Spain is driven by the Royal Decree of June 10, 1761 by Carlos III, noting that at that time the lack of roads was one of the main obstacles to national progress, as reported Jovellanos in his report on the Land Law.
[:]In the nineteenth century laws abound public roads, as are the Laws of crossings and roads, 1849 or the General Act of 1877 road, which was in force until the Roads Act 1974, in turn repealed by Law existing roads in 1988.
Following these laws are implemented successive road master plans, as approved in 1860. In the mid-eighties, the Spanish roads had a significant delay compared with the countries of our environment and they were unable to absorb the increase in traffic brought about by economic recovery, others suffer from serious security problems for their poorly laid and conservation status. For this starts the general plan of roads in 1984-1991, with a budget of 2.8 trillion pesetas, of which 12% came from the ERDF. It is as a result of this plan as drawn up and approved the current law of highways, 1988, with a view to increasing safety requirements and quality of the roads planned and future.


text:
Despite the unique challenges of 2020, Altoona continued to grow and flourish. The year saw a climb to 20,000 residents, a 37.5% INCREASE since 2010. Also, the City issued 223 new single-family residential building permits valued at $53,573,855.
Even amid the challenges of the pandemic, Altoona continued to welcome new businesses, families and developers to Iowa's Rising Star. Now, with our community positioned for further growth, the future looks brighter than ever.
Keep scrolling to learn more about Altoona's continued growth in 2020.


text:
Mindfulness and Coping with Dysphoric Mood: Contrasts with Rumination and Distraction
Cognitive Therapy and Research
Format: Journal Article
Publication Year: 2005
Source ID: shanti-sources-22389
Zotero Collections: Contemplation by Applied Subject, Psychology and Contemplation, Science and Contemplation
Abstract: Past research has shown that rumination exacerbates dysphoric mood whereas distraction attenuates it. This research examined whether the practice of mindfulness meditation could reduce dysphoric mood even more effectively than distraction. A dysphoric mood was induced in 139 female and 38 male participants who were then randomly assigned to a rumination, distraction, or meditation condition. As predicted, participants instructed to meditate reported significantly lower levels of negative mood than those in either of the two other conditions. Distraction was associated with a lessening of dysphoric mood when compared to rumination but was not as effective as mindfulness meditation. The implications of these findings are discussed.

domain: psychology


text:
Hi everyone and Happy Mother’s Day.
Welcome to our May Really Reasonable Ribbon Blog Hop.
We have a really fun Hot Pink and Black May Ribbon Club Assortment to show you this month. Isn’t it HOT, HOT, HOT?? What a fun way to build your ribbon stash so you’ll always have the color you need on hand. Looking for a gift for a crafty friend? There are gift subscriptions available for 3, 6, 9 or 12 months available.
Since today is Mother’s Day, I have two Mother’s Day cards to show you.
For my first card I used the black sheer organza with satin center for the ruched strip down the middle and the hot pink with black satin swiss dots which I tied in a knot and v-cut the ends for a little different look. So easy too!

domain: design


Waste water management in TSMC, Taiwan
Making good use of water resource is of paramount importance for any industry. Taiwan Semiconductor Manufacturing Company (TSMC), the world leading wafer foundry, began to work on waste water recycling in 1995, and has developed a brand new waste water recycling system. The rate of recycled waste water can now reach nearly 90%, which is an unmatched level.
According to a climate study by Research Center for Environmental Changes, Academia Sinica, Taiwan in 2011, Taiwan's rainfall situations becomes increasingly polarized, in that rainfall occurs less frequently in the dry season but more in the wet season. Although the average amount of rainfall in Taiwan reaches 2,500 mm, which is 2.6 times the amount of the global average, but 70% of the rainfall has flown into the ocean. The actual available and usable amount accounts for 26% of the annual rainfall amount. Taiwan has been decreed as the 18th country suffering from water shortage.
In this context, TSMC has committed to making efforts in order to reduce its huge water consumption. To achieve this task, TSMC has developed new technologies towards recycling waste water. Instead of being satisfied with meeting the minimum standard of water and wastewater treatment, TSMC has kept taking proactive measures for a promising future. Moreover, as TSMC is committed in carrying out a Corporate Social Responsibility approach, the company has no choice but to take into account the waste water treatment.
TSMC’s major water-consuming process consists in cleaning chemical residue on wafer surfaces through an ultra-pure water system. The strategic planning is a three-step approach based on (i) controlling water pollution by reducing pollutants, (ii) recycling these pollutants and (iii) recovering these pollutants. In order to reduce the global water consumption, the effluent water from ultra-pure water systems and process tools are rated (depending on their purity), using a strict classification. The purest water is reused in the production scheduling process whereas the poorest grade goes to secondary uses (human contact is avoided) such as water for cooling towers and wet scrubbers, cleaning water for sludge dewatering filters, and toilet water. Wastewater that cannot be recycled is discharged to treatment facilities for final wastewater treatment.
Why did it work?
The wastewater under the chemical separation and physical separation can be split into fluoride, copper, general acid, and various polishing wastewaters. Every type of wastewater is strictly classified at process tools, and directed to wastewater treatment facilities through distinct piping devices. More than 20 categories of drainage types are used, carefully operated and maintained to meet the standards of the Science Park Administration.
Also, TSMC works in partnership with industries and universities to improve discharge quality in fields like Chemical Oxygen Demand (COD), Tetra-methyl ammonium hydroxide (TMAH) and NH3-N reduction in order to reduce hazards towards water bodies. As a result, it has led to 62.5% of the COD discharge reduction in 12-inch fabs.
Based on an internal study in TSMC in 2013, the entire recycling rate of process water accounted for 86.5% in 2012, which also economically generated 40 million EUROs profit and attested the invlovment of TSMC in water savings.
As a renowned international company, TSMC has not adopted a minimum process water recycling rate of 85% but has also selected low water consumption process tools, implemented process water drainage segregation, set up processes with reclaimed water systems in several new factories, and has continued promoting water saving measures for mass production. The purpose of such an approach is to reduce the fresh water demand.
TSMC’s overarching goal is to be a leading global company in water resource management. This objective is based on water savings in daily operations and on implementing the developed separating measures in the supply chain. Based on its achievement so far, its maturity is estimated to be 9 on TRL scale.


text:
Easy Sauteed Mushrooms
Ready for a delicious side dish for many meals like steaks, chicken, prime rib, filet mignon... these easy sauteed mushrooms is going to add a delicious level of flavor to so many meals. Quick and easy to prepare.
Prep Time 5 minutes
Cook Time 15 minutes
Total Time 20 minutes
Servings 4 servings
- 1 teaspoon unsalted butter, split into 2 1/2 pieces
- 1 teaspoon olive oil
- 2 cloves garlic, minced
- 1 small shallot, peeled and minced
- 1 pound button mushrooms, cleaned and sliced thin can use crimini or baby Bella
- 1/3 cup white wine
- 2 splashes Worcestershire Sauce
- salt and pepper, to taste
- 1 Tablespoon fresh parsley, chopped can use 1 teaspoon dried parsley
In a medium saute pan, over medium heat add 1/2 teaspoon unsalted butter and olive oil to melt and hot enough that the butter is beginning to bubble. Add to the pan the garlic and shallot. Saute and stir for about 1 minute.
Add the other 1/2 teaspoon unsalted butter to the saute pan. Add the sliced mushrooms and season with salt and pepper. Saute for about 1 minute. Add the white wine and Worcestershire Sauce, increase heat to medium-high. Cover the saute pan and let the flavors blend and the wine reduces about 5 minutes.
Remove from the heat and add the fresh parsley. Check seasoning, re-season if necessary. Add the chopped parsley and serve as a side dish.
- Any nutritional value used is an estimate. These figures can change based on ingredients and portion size
Serving: 1serving | Calories: 61kcal | Carbohydrates: 4g | Protein: 3g | Fat: 2g | Saturated Fat: 0g | Cholesterol: 2mg | Sodium: 7mg | Potassium: 374mg | Fiber: 1g | Sugar: 2g | Vitamin A: 115IU | Vitamin C: 4.2mg | Calcium: 6mg | Iron: 0.7mg


text:
Our lab primarily studies neural oscillations—or “brain waves”. Despite them being one of the first-ever signals observed in the human brain back in 1929, we know surprisingly little about where neural oscillations come from, what they do, or even if they’re functional or “accidental”.
Neural oscillations are correlated with nearly every aspect of healthy brain function and neurological/psychiatric disease, ranging from memory, attention, and motor control to depression, Alzheimer’s disease, and ADHD. Despite this, our lab steps back, beginning from two very simple questions:
We do this from two complementary angles. From the experimental side, we conduct human cognitive experiments while recording either non-invasive electrical brain activity using EEG, or invasively by working with patients undergoing brain surgery (usually for epilepsy). We also collaborate extensively with researchers in a variety or other domains, and make considerable use of publicly available brain data (which we help catalog here).
We combine these experimental approaches with large scale data-mining, data science approaches, and machine-learning techniques to discover neural features—oscillatory and otherwise—that are informative of cognitive states.
From the computational side, we develop new methods for measuring and quantifying neural oscillations in both the time- and frequency domains (see our publications for our latest research). We also build models of neural circuitry to probe the computational capabilities of neural populations to investigate how oscillations impact computation and communication. Additionally, we model how these circuits contribute to the electrical brain signals we record. We validate these models by comparing to a wide range of electrophysiological data, including single-unit recordings and intracranial field potentials from humans and animals.
Ultimately, our research goal is to bridge these two approaches and construct an understanding of cognition built on the first principles of neurophysiology. Rather than asking, “What brain regions correlate with working memory or attentional load?” we ask, “Given what we know about the computational properties of neurons and neural systems, how can neural systems interact to give rise to cognitive phenomena we equate with ‘attention’ and ‘working memory’, and what are the behavioral and cognitive limitations and consequences of these biological constraints?”
In collaboration with his wife, Jessica Bolger Voytek, Voytek built and published brainSCANr, an algorithmic approach to aggregating information from more than 2 million peer-reviewed neuroscience articles. This project was his first attempt at automated science: using machine-learning tools to algorithmically generate novel hypotheses. Our philosophy with regards to the role of data-driven approaches to neuroscience is that large scale data analytics can complement and guide in-lab experimental research, but should not replace it.

domain: biology


The DEWALT 20V MAX lithium ion 3/8-inch right angle drill/driver has dual speed ranges (0-500/0-2000 rpm) for increased user flexibility.
Compact front to back length (only 4 inches) allowing users to fit it into hard to reach spaces
Multi-grip trigger provides comfort and convenience allowing the user to get into tighter spaces
Kit includes drill belt hook and 2 Phillips bit. Batteries not included
Dual speed ranges (0-650/0-2000) rpm for increased user flexibility


text:
SANTA BARBARA COUNTY, Calif. (KABC) -- Santa Barbara County firefighters rescued a dog who was in a bit off a ruff spot after it got stuck in a kitchen sink.
The fire department shared the photos online of the rescue last week.
A woman called for help after her dog, named Sugar, got stuck in the sink while she was giving it a bath.
A medic engine responded and was able to free the dog in about 10 minutes. The firefighters also put the drain back together when they were done.


text:
In the bustling market of today’s economy, small business owners, retailers, and e-commerce entrepreneurs stand at a crossroads of consumer expectations and technological advancement. The ability to accept credit card payments is no longer a luxury but a necessity for businesses of all sizes. Yet, some common misconceptions linger, holding back businesses from embracing this pivotal element of modern commerce. Here, we unravel the immense benefits of credit card payments and debunk prevalent myths.
The evolution of payment methods is in full swing, with credit cards at the helm driving convenience, security, and efficiency. Accepting credit card payments is indispensable in enhancing the customer experience and propelling business growth. This blog post aims to demystify credit card processing and illustrate why it’s an invaluable asset for your business.
Benefits for Small Business Owners
Increased Sales and Revenue
Accepting credit cards can significantly widen your customer base. It opens doors to those who prefer cashless transactions, leading to an uptick in sales and potentially higher revenue. By facilitating easy payment, you tap into a larger segment of the consumer market.
Improved Customer Convenience
The comfort of your customers is paramount, and nothing spells convenience like the ease of a credit card swipe or tap. Offering a variety of payment options caters to different customer preferences, contributing to positive buying experiences and return business.
Enhanced Credibility and Professionalism
Displaying credit card logos at your point of sale or website enhances your professional image. It signals to customers that your business is reputable and trustworthy, leading to increased consumer confidence in your brand.
Benefits for Retailers
Higher Average Transaction Value
Studies show that customers are likely to spend more when using credit cards over cash. For retailers, this means an opportunity to boost the average transaction value, enhancing overall profitability.
Reduced Risk of Fraud
Credit card companies invest in sophisticated anti-fraud technologies to protect cardholders and merchants alike. By utilizing merchant services with built-in security features, retailers can mitigate the risk of fraud, providing peace of mind for both the business and its patrons.
Streamlined Payment Processes
Digital transactions enable a sleeker payment process. With credit cards, the hassle of handling cash is significantly reduced, allowing for a more efficient checkout experience that customers appreciate.
Benefits for E-commerce Entrepreneurs
Global Reach and Expansion Opportunities
Credit card acceptance is a ticket to international markets. It eliminates geographical barriers, enabling e-commerce entrepreneurs to sell to customers around the globe without the complications of currency exchange.
Increased Conversion Rates
A smooth checkout process augmented by credit card payment options can decrease cart abandonment rates. With frictionless transactions, businesses can witness improved conversion rates and customer retention.
Access to Valuable Customer Data
Credit card transactions provide a wealth of analytical data. This information can be leveraged to refine marketing strategies, tailor customer experiences, and drive informed business decisions.
Addressing Common Misconceptions
“Credit card payments are only for big businesses”
Small and medium-sized enterprises stand to gain substantially from credit card acceptance, breaking the myth that plastic is for corporate giants only.
“High processing fees make credit cards an expensive option”
While there are associated processing fees, the increase in sales volume and efficiency often justifies the cost, offering a net-positive outcome.
“Credit card payments are unsafe”
Robust encryption and security protocols make credit card payments among the safest options available, protecting against data breaches and unauthorized transactions.
Embracing credit card payments could very well be the catalyst for your business to reach new heights. With the potential for increased revenue, expanded customer base, enhanced security, and deeper market insights, the question is not if you should accept credit cards but when you will start.
Transform your business and cater to the modern consumer by embracing the power of credit card payments today. Don’t let misconceptions deter you from the path to success. Welcome the future, and watch your business thrive.
Are you ready to elevate your payment methodology and take your business upward and onward? Embrace the Power of Credit Card Payments Today by implementing this seamless transaction method to bolster your growth and satisfy customer demands.


Harbor Springs plans for spring, summer activities
HARBOR SPRINGS — A variety of outdoor spring and summer activities in downtown Harbor Springs were approved by the city council on Monday.
Following a year in which many traditional events were either canceled or modified in response to the COVID-19 pandemic, council members voiced their approval for activities both new and old to take place in 2021.
First up on the calendar is Bowling Down Main Street. This event has taken place for many years during the quiet spring break period, when it’s said the town is so quiet you could bowl down Main Street.
“The staff supports this event and we see no issues with it going forward as planned, so long as the organizers adhere to any change in COVID-19 rules and gatherings and social distancing,” said city manager Victor Sinadinoski.
The event is scheduled from noon to 2 p.m. on Saturday, April 3. Currently, Johan’s is set to provide hot chocolate and doughnuts, and the Rocking Horse Toy Company will also have a grab-gift for children.
Another longstanding tradition, the Harbor Springs Farmers Market, also received council approval on Monday.
“They are planning to come back from May 29 through Oct. 16 on Saturdays, and then as well as on Wednesdays starting June 2 through Aug. 25,” Sinadinoski said.
Last year, the farmers market was able to safely open with several changes made to abide by state regulations. Vendors were more spread out, face masks were required while at the market and capacity was limited.
Two new events organized by the chamber of commerce were also approved by council on Monday.
Tuesday Night Movies at the Park is set to show two movies from 9:30 to 11:30 p.m. on July 6 and July 20 at Zorn Park.
“They are showing movies I think that are PG … but the titles aren’t known yet,” Sinadinoski said. “They’re still working on setup and orientation of the screen.”
Sinadinoski added that the chamber is working with the Department of Public Works to ensure there is power for the movies, and also asked that the chamber run any titles past city staff to make sure they are appropriate choices.
Council member Al Dika expressed concern about whether the noise from the park would disturb neighbors, and chamber of commerce director Bonnie Kulp said she would be flexible to any changes that were needed.
The chamber is also organizing Friday Night Music in the Park. This is scheduled to take place at Marina Park on July 16, July 23, Aug. 6 and Aug. 13. The free performances would be between 6:30 and 8:30 p.m.
“Staff again supports this event, and of course the same goes with all events this year, is to ensure that the organizers adhere to COVID-19 rules and restrictions on gathering limits and social distancing,” Sinadinoski said.
The council unanimously approved all four of the events as presented.
Monday’s full city council meeting is available to view at www.youtube.com/watch?v=nwsqkb_VXI0.


text:
Send this profile to a friend
News from The Business Journals
May 1, 2013, 2:52 pm EDT
A subsidiary of The Home Depot Inc. that distributes contracting supplies and materials has leased all of a 92,699-square-foot warehouse in Capitol He ...
Jan 27, 2012, 6:00 am EST
A new rule has cost Atlanta’s three largest banks a combined $700 million in fee income, the banks’ quarterly financial reports show.
Jun 20, 2011, 11:54 am EDT
If Sears Holdings Inc. does decide to relocate its headquarters to the D.C. area, it would be unusual for an area lacking in major retailers based her ...
Jun 13, 2011, 1:49 pm EDT
One of the most recognizable names in household cleansers is looking to expand its car washing business and is eyeing Baltimore for growth.
May 9, 2011, 2:56 pm EDT
DeWalt is ramping up its marketing game by stepping back into the boxing ring.
Apr 11, 2011, 11:06 am EDT
Austin-based mobile website developer Digby Inc. has teamed with telecommunications giant AT&T Inc. to launch a new service for retailers.
Mar 22, 2011, 4:20 pm EDT
When it comes to growth in 2011, American retailers’ expansion plans have increased 40 percent, according to ChainLinks' Retail Advisors Spring 2011 N ...
Mar 15, 2011, 6:52 am EDT
A University of Georgia professor is leading research with scientists in South Korea to determine if certain plants can be developed to create super-e ...
Mar 4, 2011, 6:00 am EST
Tyra Johnson wanted to be an entrepreneur for a long time. And working the last eight years in the construction industry opened her eyes to an opportu ...


Proposed Laws in Brazil would Imprison you for Vaccine Refusal
English language media sources covering Brazil report that the South American nation’s Congress has developed six bills to criminalize various behaviors associated with the COVID-19 vaccines, from cutting in line to get a vaccine to propagating so-called “fake news” or news perhaps that may even be true but serves as inconvenient to various governmental authorities under the new left-leaning government. Senator Angelo Coronel (PSD-BA) has authored PL 555/2020, which anticipates criminal charges for one to three years for people who omit or even stand in opposition to mandatory COVID-19 vaccination of children or adolescents during a declared “public health authority.” What? Do Brazilian politicians want to criminalize people that simply have concerns about specific vaccines? This goes too far.
But it gets worse. The proposed law would penalize a person that refuses to take the mandatory jab with up to eight years in prison!
You can support this ministry and keep us on the internet using the links below. Patreon is gone so now we havePayPal, Cash App and Buy me a Coffee as our online options. The new buy me a coffee link is below.
Cash App ID: $jstorm212


A chieftain of the All Progressives Congress, APC, Joe Igbokwe has criticised the former Deputy Senate President, Ike Ekweremadu’s son, Lloyd, for having an elaborate wedding event in the absence of his parents, who are currently in prison in the United Kingdom.
Lloyd got married to Tiffany Adaobi Obinna-Uzor at the Basilica of Grace, Anglican Communion, Gudu District, Abuja, on Saturday.
In his reaction to Lloyd’s wedding, Igbokwe wrote on his Facebook page, saying it was an elaborate event, adding that the former Senator’s son was insensitive to the plight of his parents that are in jail.
The APC chieftain said Lloyd should have organised a very low-budget wedding and celebrated an elaborate one when his parents return from prison.
Ekweremadu and his wife, Beatrice, are serving in a UK prison after they were convicted of organ trafficking by a London court in May, in their an attempt to help their ailing daughter, Sonia.
They were sentenced alongside a middleman, Dr Obinna Obeta, who wanted to carry out the organ harvest operation on David Ukpo Nwamini, the boy trafficked from Lagos to London.
Ekweremadu was served nine years and eight months, while his wife was handed four years and six months. The doctor was sentenced to 10 years in prison.
Recalling their ordeal in relation to their son’s wedding ceremony, Igbokwe said: “If I were to be Ekweremmadu’s son I would not have staged this elaborate wedding ceremony with my father and mother in prison.
“I would have done a low-key marriage ceremony and waited till my parents are free. This generation scares me stiff,” he added.


text:
(5α,7β,9α,10β,13α)-7,9,10,13-tetrakis(acetyloxy)taxa-4(20),11-dien-5-yl (2E)-3-phenylprop-2-enoate/2-Propenoic acid, 3-phenyl-, (1S,3S,4aR,6R,8S,11R,12R,12aS)-1,8,11,12-tetrakis(acetyloxy)-1,2,3,4,4a,5,6,7,8,11,12,12a-dodecahydro-9,12a,13,13-tetramethyl-4-methylene-6,10-methanobenzocyclodecen-3-yl ester, (2E)-/(5α,7β,9α,10β,13α)-7,9,10,13-Tetraacetoxytaxa-4(20),11-dien-5-yl (2E)-3-phenylacrylate
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
673.8±55.0 °C at 760 mmHg
HS Code Reference
Personal Projective Equipment
For Reference Standard and R&D, Not for Human Use Directly.
provides coniferyl ferulate(CAS#:119347-14-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of coniferyl ferulate are included as well.>> amp version: coniferyl ferulate
To examine factors associated with 0? to 7?day admission after outpatient surgery in high?volume specialties: general surgery, orthopedics, urology, ear/nose/throat, and podiatry.
We calculated rates and assessed diagnosis codes for 0? to 7?day admission after outpatient surgery for Centers for Medicare and Medicaid Services (CMS) and Veterans Health Administration (VA) dually enrolled patients age 65 and older. We also estimated separate multilevel logistic regression models to compare patient, procedure, and facility characteristics associated with postoperative admission.
2011-2013 surgical encounter data from the VA Corporate Data Warehouse; geographic data from the Area Health Resources File; CMS enrollment and hospital admission data.
Among 63,585 outpatient surgeries in 124 facilities, 0? to 7?day admission rates ranged from 5 percent (podiatry) to 28 percent (urology); nearly 66 percent of the admissions occurred on the day of surgery. Only 97 admissions were detected in the CMS data (1 percent). Surgical complications were diagnosed in 4 percent of admissions. Procedure complexity, measured by relative value units or anesthesia risk score, was associated with admission across all specialties.
As many as 20 percent of VA outpatient surgeries result in an admission. Complex procedures are more likely to be followed by admission, but more evidence is required to determine how many of these reflect potential safety or quality problems.
Ambulatory surgery, adverse event detection, readmissions, health services research, Veterans Health Administration
Factors Associated with Hospital Admission after Outpatient Surgery in the Veterans Health Administration
Hillary J. Mull, Ph.D., M.P.P.,corresponding author 1 , 2 Amy K. Rosen, Ph.D., 1 , 2 William J. O'Brien, M.S., 1 Nathalie McIntosh, Ph.D., 3 Aaron Legler, M.P.H., 4 Mary T. Hawn, M.D., M.P.H., 5 , 6 Kamal M. F. Itani, M.D., 2 , 7 , 8 and Steven D. Pizer, Ph.D. 4 , 9
Beginning with precursor lesions, aberrant DNA methylation marks the entire spectrum of prostate cancer progression. We mapped the global DNA methylation patterns in select prostate tissues and cell lines using MethylPlex-next-generation sequencing (M-NGS). Hidden Markov model-based next-generation sequence analysis identified ∼68,000 methylated regions per sample. While global CpG island (CGI) methylation was not differential between benign adjacent and cancer samples, overall promoter CGI methylation significantly increased from ∼12.6% in benign samples to 19.3% and 21.8% in localized and metastatic cancer tissues, respectively (P-value < 2 × 10?16). We found distinct patterns of promoter methylation around transcription start sites, where methylation occurred not only on the CGIs, but also on flanking regions and CGI sparse promoters. Among the 6691 methylated promoters in prostate tissues, 2481 differentially methylated regions (DMRs) are cancer-specific, including numerous novel DMRs. A novel cancer-specific DMR in the WFDC2 promoter showed frequent methylation in cancer (17/22 tissues, 6/6 cell lines), but not in the benign tissues (0/10) and normal PrEC cells. Integration of LNCaP DNA methylation and H3K4me3 data suggested an epigenetic mechanism for alternate transcription start site utilization, and these modifications segregated into distinct regions when present on the same promoter. Finally, we observed differences in repeat element methylation, particularly LINE-1, between ERG gene fusion-positive and -negative cancers, and we confirmed this observation using pyrosequencing on a tissue panel. This comprehensive methylome map will further our understanding of epigenetic regulation in prostate cancer progression.
Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer
Jung H. Kim,1,11 Saravana M. Dhanasekaran,1,2,11 John R. Prensner,1 Xuhong Cao,1 Daniel Robinson,1 Shanker Kalyana-Sundaram,1,3 Christina Huang,1 Sunita Shankar,1 Xiaojun Jing,1 Matthew Iyer,1 Ming Hu,4,12 Lee Sam,1,2 Catherine Grasso,1 Christopher A. Maher,1,2,5 Nallasivam Palanisamy,1 Rohit Mehra,1 Hal D. Kominsky,1 Javed Siddiqui,1 Jindan Yu,6 Zhaohui S. Qin,7 and Arul M. Chinnaiyan1,2,5,8,9,10,13
The epidemiology and risk factors for hepatitis C virus (HCV) infection in Rwanda are not well known; however, this information is crucial to shaping the country’s public health approach to hepatitis C control.
A HCV screening campaign was conducted in the general population in 24 districts previously identified to have a high HCV disease burden. At the time of sample collection, sociodemographic information and self-reported risk factors were collected. Bivariate and multivariate logistic regressions were conducted to assess risk factors independently associated with hepatitis C antibodies (HCVAb) seroprevalence.
Out of a total of 326,263 individuals screened for HCVAb, 22,183 (6.8%) were positive. In multivariate analysis, risk factors identified as statistically associated with HCVAb Seroprevalence include history of traditional operation or scarification (OR = 1.09, 95% CI: 1.05-1.14), presence of viral hepatitis in the family (OR = 1.27, 95% CI: 1.15-1.40), widowed or separated/divorced (OR = 1.36, 95% CI: 1.26-1.47), Southern province (OR = 1.98, 95% CI: 1.88-2.08) and aged 65 years and older (OR = 4.86, 95% CI: 4.62-5.11). Ubudehe category 3 (OR = 0.97, 95% CI: 0.93-1.01) and participants using RAMA (Health insurances for employees of public and private sectors) insurance (OR = 0.76, 95% CI: 0.70-0.85) had lower odds of HCV seroprevalence.
Our findings provide important information for Rwanda’s strategy on prevention and case-finding. Future prevention interventions should aim to reduce transmission through targeted messaging around traditional healing practices and case-finding targeting individuals with a history of exposure or advanced age.
Viral hepatitis C, Risk factors, Rwanda
Risk factors for viral hepatitis C infection in Rwanda: results from a nationwide screening program
Jean Damascene Makuza,corresponding author1 Carol Y. Liu,2 Corneille Killy Ntihabose,1 Donatha Dushimiyimana,1 Sabine Umuraza,2 Marie Paul Nisingizwe,3 Justine Umutesi,1 Janvier Serumondo,1 Soline Dusabeyesu Mugeni,2 Muhamed Semakula,1 Neil Gupta,4 Margaret Hellard,5 and Sabin Nsanzimana1

domain: medical


Folks far and high are either quitting or staying off the microblogging platform to protest the Tesla CEO's leadership. This includes some of our favorite celebrities. Keep scrolling to see which A-listers have officially decided to part ways with the social media app below.
Amber Heard, who previously dated Elon, quietly deactivated her account. While she never gave a reason, her exit seemed intentional as it was just days after Elon took over.
Singer Sara Bareilles publicly announced her departure from the platform. "Welp. It’s been fun Twitter. I’m out. See you on other platforms, peeps. Sorry, this one’s just not for me," she wrote in her final tweet.
Model Gigi Hadid pulled the plug on her account, too. She shared the news alongside a tweet from a former member of Twitter's human rights team who discussed the recent layoffs.
"I deactivated my Twitter account today. For a long time, but especially with its new leadership, it's becoming more and more of a cesspool of hate and bigotry, and it's not a place I want to be a part of," Gigi wrote.
Thirtysomething star Ken Olin went out with a poem. He encouraged his followers to keep fighting for democracy, to be kinder and more generous, and to help save the planet.
Singer Toni Braxton has up and left. In her final tweet, she claimed that since Elon took over, she's seen some "free speech" on the platform that sounded a lot like hate speech. "I am choosing to stay off Twitter as it is no longer a safe space for myself, my sons, and other POC," she wrote.
To further back her point, the social media research group Network Contagion Research Institute actually reported that within a 12-hour period in the early days of Elon's tenure, the use of the N-word on the platform had increased nearly 500 percent.
Actor and ex-pro wrestler Mick Foley shared the news on Facebook that he would be taking a break from Twitter. "I decided I needed a Twitter break, since the new ownership — and the misinformation and hate it seems to be encouraging — has my stomach in a knot," he wrote in his post.