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Last Modified: May 5th, 2020
These Terms of Service and any terms expressly incorporated herein (these “Terms”) are entered into by and between you and Privacy Bee, LLC (Privacy Bee) and govern the terms of Privacy Bee’s affiliate program (Hive)
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You will receive commission for Qualified Referrals to Privacy Bee. The percentage of commission may change at any time and without notice.
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Neither these Terms of Service nor your participation in the Affiliate Program creates any employment, independent contractor, agency, partnership, or joint venture relationship between you and Privacy Bee.
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You are solely responsible for ensuring that your participation in the Affiliate Program complies with applicable law and does not violate the rights of any third party, including, without limitation, intellectual property rights. You assume all liability for any claims, suits or grievances filed against you, including, but not limited to, all damages related to participation in the Affiliate Program.
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In using the Services, you may view content provided by third parties (“Third-Party Content”). We do not control, endorse, or adopt any Third-Party Content and shall have no responsibility for ThirdParty Content, including without limitation material that may be misleading, incomplete, erroneous, offensive, indecent, or otherwise objectionable. In addition, your business dealings or correspondence with such third parties are solely between you and the third parties. We are not responsible or liable for any loss or damage of any sort incurred as the result of any such dealings, and you understand that your use of Third-Party Content, and your interactions with third parties, is at your own risk.
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YOU ACKNOWLEDGE THAT YOUR USER DATA MAY BECOME IRRETRIEVABLY LOST OR CORRUPTED OR TEMPORARILY UNAVAILABLE DUE TO A VARIETY OF CAUSES, INCLUDING SOFTWARE FAILURES, VIRUSES OR OTHER HARMFUL MATERIALS, PROTOCOL CHANGES BY THIRD PARTY PROVIDERS, INTERNET OUTAGES, FORCE MAJEURE EVENT OR OTHER DISASTERS, SCHEDULED OR UNSCHEDULED MAINTENANCE, OR OTHER CAUSES EITHER WITHIN OR OUTSIDE OUR CONTROL. YOU ARE SOLELY RESPONSIBLE FOR BACKING UP AND MAINTAINING DUPLICATE COPIES OF ANY INFORMATION YOU STORE OR TRANSFER THROUGH OUR SERVICES.
THE DISCLAIMER OF IMPLIED WARRANTIES CONTAINED HEREIN MAY NOT APPLY IF AND TO THE EXTENT IT IS PROHIBITED BY APPLICABLE LAW OF THE JURISDICTION IN WHICH YOU RESIDE.
You will defend, indemnify, and hold harmless us, our Affiliates, and their respective shareholders, members, directors, officers, employees, attorneys, agents, representatives, suppliers and contractors (collectively, “Indemnified Parties”) from any claim, demand, lawsuit, action, proceeding, investigation, liability, damage, loss, cost or expense, including without limitation reasonable attorneys’ fees, arising out or relating to (a) your use of, or conduct in connection with, the Services; (b) any Feedback or User Content you provide; (c) your violation of these Terms; or (d) your violation of any applicable law or the rights of any other person or entity. If you are obligated to indemnify any Indemnified Party, we (or, at our discretion, the applicable Indemnified Party) will have the right, in its sole discretion, to control any action or proceeding and to determine whether we wish to settle, and if so, on what terms.
11. Disclaimer of Damages.
IN NO EVENT WILL WE, OUR AFFILIATES AND THEIR RESPECTIVE SHAREHOLDERS, MEMBERS, DIRECTORS, OFFICERS, EMPLOYEES, ATTORNEYS, AGENTS, REPRESENTATIVES, SUPPLIERS OR CONTRACTORS BE LIABLE FOR ANY INCIDENTAL, INDIRECT, SPECIAL, PUNITIVE, CONSEQUENTIAL OR SIMILAR DAMAGES OR LIABILITIES WHATSOEVER (INCLUDING, WITHOUT LIMITATION, DAMAGES FOR LOSS OF DATA, INFORMATION, OR FINANCIAL BENEFIT) ARISING OUT OF OR IN CONNECTION WITH THE SITE, THE SERVICES, ANY PERFORMANCE OR NON-PERFORMANCE OF THE SERVICES, OR ANY OTHER PRODUCT, SERVICE OR OTHER ITEM PROVIDED BY OR ON BEHALF OF US, WHETHER UNDER CONTRACT, STATUTE, STRICT LIABILITY OR OTHER THEORY (INCLUDING, FOR AVOIDANCE OF DOUBT, ANY NEGLIGENCE OF OURS), EVEN IF WE HAVE BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES.
12. Limitation of Liability.
IN NO EVENT WILL OUR LIABILITY, OUR AFFILIATES AND THEIR RESPECTIVE SHAREHOLDERS, MEMBERS, DIRECTORS, OFFICERS, EMPLOYEES, ATTORNEYS, AGENTS, REPRESENTATIVES, SUPPLIERS OR CONTRACTORS ARISING OUT OF OR IN CONNECTION WITH SITE, THE SERVICES, ANY PERFORMANCE OR NON-PERFORMANCE OF THE SERVICES, OR ANY OTHER PRODUCT, SERVICE OR OTHER ITEM PROVIDED BY OR ON OUR BEHALF, WHETHER UNDER CONTRACT, STATUTE, STRICT LIABILITY OR OTHER THEORY (INCLUDING, FOR AVOIDANCE OF DOUBT, ANY NEGLIGENCE OF OURS) EXCEED THE AMOUNT OF THE FEES PAID BY YOU TO US UNDER THIS AGREEMENT IN THE ONE-MONTH PERIOD IMMEDIATELY PRECEDING THE EVENT GIVING RISE TO THE CLAIM FOR LIABILITY.
13. Changes; Suspension; Termination.
13.1 Changes to the Service. We may, at our discretion and without liability to you, with or without prior notice and at any time, modify or discontinue, temporarily or permanently, all or any portion of any the Services.
13.2Suspension or Termination of Services.
(a)We may, at our discretion and without liability to you, with or without prior notice and at any time, temporarily suspend or permanently terminate your access to all or a portion of any the Services. Such action would constitute a withdrawal from our representation, cancellation or annulment of any Power of Attorney, or any authorizations related thereto, that may have been granted during the provision of the Services.
(b)You have the right to terminate your Subscription and use of the Services at any time by providing notice to us of your intent to terminate (a “Termination Request”). You acknowledge that, on the effective date of your Termination Request (the “Termination Date”), your license to utilize the Services shall cease immediately, and you shall no longer have rights to use the same. If your Termination Request does not specify a Termination Date, then the Termination Request shall be deemed effective upon our receipt of the same. Following the Termination Date, you agree to immediately cease the use of all the Services. You acknowledge and agree that, following the Termination Date, we shall have no obligation to maintain, provide to you, or recover any of the data or content that you uploaded to your Account and/or the Services, and we may delete the same. In the event of a termination, pursuant to this Section 13(b), we shall have no obligation to provide you with a refund of any Fees that you have prepaid, as all Fees paid by you are final and non-refundable.
13.3 No liability. We will not be liable for any losses suffered by you resulting from any modification of any Services or from any suspension or termination of your access to all or a portion of any Services (whether pursuant to this Section 13 or for any other reason).
13.4 Effect of Termination. In the event of discontinuation of all Services or other termination of your right to access all Services: (a) all amounts payable by you to us will immediately become due; (b) we may delete or deactivate your Account and all related information and files in such Account without liability to you.
14. Contact Us.
All feedback, comments, requests for technical support and other communications relating to the Services should be directed to: [email protected].
15.1 Governing Law. The interpretation and enforcement of these Terms, and any dispute related to these Terms or the Services, will be governed by and construed and enforced in accordance with the laws of the State of Wyoming, without regard to conflict of law rules or principles (whether of California or any other jurisdiction) that would cause the application of the laws of any other jurisdiction. You agree that we may initiate a proceeding related to the enforcement or validity of our Intellectual Property Rights in any court having jurisdiction. With respect to any other proceeding that is not subject to arbitration under these Terms, the federal and state courts located in Wyoming will have exclusive jurisdiction. You waive any objection to venue in any such courts.
15.2 Assignment. These Terms are binding upon and inure to the benefit of the permitted successors and assigns of each party. You may not assign, subcontract, delegate or otherwise convey these Terms, or any of its rights and obligations hereunder. Notwithstanding anything to the contrary in these Terms, we may assign, transfer, and delegate this agreement (these Terms) and its obligations hereunder at any time, in its sole discretion.
15.3 Severability. If any provision of these Terms is held to be invalid, illegal, or unenforceable, the validity, legality, and enforceability of any such provision in every other respect and the remaining provisions of these Terms will be unimpaired and these Terms will continue in full force and effect, unless the provisions held invalid, illegal, or unenforceable will substantially impair the benefits of the remaining provisions hereof.
15.4 Waiver. The failure of either party to insist upon strict performance or to seek remedy for breach of any term of these Terms, or to exercise any right, remedy or election herein or permitted by law or equity, will not constitute nor be construed as a waiver or relinquishment in the future of such term, condition, right, remedy, or election. Any consent, waiver, or approval by either party of any act or matter will not be effective unless made in writing and signed by an authorized representative of the consenting, waiving, or approving party.
15.5 Force Majeure. We will not be responsible or liable to you or deemed in default or breach hereunder by reason of any failure or delay in the performance of its obligations hereunder (including the temporary unavailability or inaccessibility of the Services) where such failure is the result of Force Majeure. As defined herein, “Force Majeure” means any (a) acts of God, flood, fire, wind, storm, drought, earthquake, or other natural disaster; (b) epidemic or pandemic; (c) terrorist attack, civil war, civil commotion or riots, war, threat of or preparation for war, armed conflict, imposition of sanctions, embargo, or breaking off of diplomatic relations; (d) nuclear, chemical or biological contamination, or sonic boom; (e) any law or any action taken by a government or public authority; (f) collapse of buildings, breakdown of plant or machinery, fire, explosion, or accident; (g) any labor or trade dispute, materials or transport, strikes, industrial action or lockouts; (h) interruption or failure of utility service; or (i) or any other cause, whether similar or dissimilar to those enumerated, that is beyond our reasonable control and without our fault or negligence.
15.6 Survival. Termination of these Terms will not affect the provisions that, by their nature, are intended to survive the termination hereof, including without limitation, Section 5,6,7,8,9,10,11,12,13,14, and 15.
15.7 Entire Agreement; Order of Precedence. These Terms contain the entire agreement and supersede all prior and contemporaneous understandings between the parties regarding the Services. In the event of any conflict between these Terms and any other agreement you may have with us, these Terms will control unless the other agreement specifically identifies these Terms and declares that the other agreement supersedes these Terms.

domain: law


The Accuracy of Face ID on iPhone X
While it appears most might agree iPhone X’s Face ID has been effective and unproblematic, others unluckily seem to have struggled with a wide variety of issues that have prevented them from getting the only and correct reaction.
While Apple has promised earlier than that Face ID will best improve with time through ordinary software program updates, iPhone X customers who’re nevertheless experiencing problems with the effectiveness and accuracy in their Face ID systems don’t technically need to take a seat around and watch for the updates to begin rolling in.
Thankfully, our exact buddies over at 9to5Mac have drummed up a shortlist of no-nonsense techniques which may additionally assist enhance your experience using Face ID now. So use the Right Arrow to Learn 4 Pro Tips to Maximize the Accuracy of Face ID on iPhone X.
Apple announced a new and high-priced version of its popular phone – iPhone X – in September. The agency sooner or later made iPhone X to be had in more than 55 countries and territories. In addition to providing a facet-to-aspect OLED show, iPhone X also comes with several out-of-container features to venture the dominance of the Android platform.
At the equal time, the special iPhone model also comes with a one-of-a-kind facial reputation machine – Face ID. Face ID allows users to use their faces much like traditional passwords. The facial scanning device allows a user to release his iPhone X truly by searching in the direction of the smartphone along with his eyes open. He may even use Face ID to keep the statistics stored on his iPhone X secure and make cellular payments.
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However, Face ID in iPhone X takes some other sturdy hardware function covered inside the telephone – TrueDepth digicam. Many analysts believe that Apple will quickly make the modern facial scanning system available to different iPhone and iPad models. Hence, the iOS developers ought to apprehend crucial factors of Face ID in iPhone X to fulfill the rising mobile app development fashion.
Important Aspects of Face ID in iPhone X each iOS App Developer Must Know
Replaces Touch ID on iPhone X
Touch ID was a crucial part of several iPhone models. The authentication device allows customers to unlock their smartphones simply utilizing putting their palms on the sensor. A person can even use Touch ID to carry out numerous economic transactions and cell payments. iPhone X is designed with Face ID rather than Touch ID. Unlike Touch ID, Face ID does not require customers to touch their smartphones. A person can take benefit of Face ID to unencumber his device genuinely by using glancing on display. At the same time, iOS app developers can take advantage of the brand new facial popularity system with the aid of changing the Touch ID code with Face ID code.
Does now not make Passcodes Obsolete
Despite replacing Touch ID on iPhone X, Face ID is but to replace passcodes completely. Apple recommends iPhone X users to apply passcodes whilst restarting the device, the device has remained unlocked for greater than 48 hours, and the user has attempted wrong face healthy 5 times. Also, a consumer has to use a passcode to make his iPhone X handy to friends and own family participants.
Authenticates through TrueDepth Camera
Face ID authenticates customers thru every other new characteristic provided by the iPhone X – TrueDepth camera device. The advanced digicam gadget captures all features of a user’s face thru intensity mapping. Also, TrueDepth creates a unique facial map to take pictures of over 30000 invisible dots projected onto a person’s face. Each time a user unlocks his iPhone X, TrueDepth Camera reads the dot patterns thru an infrared digicam and captures an infrared photo. It subsequently sends the infrared photograph to Secure Enclave inside the A11 Bionic chip. Once the authenticity of the infrared photograph is showing, the iPhone gets unlocked.
Uses Machine Learning
A consumer’s look can also differ sometimes. Face ID uses machine getting to know algorithms to recognize the modifications in a person’s appearance. Hence, a person can liberate his iPhone X regardless of his modern-day appearance. He can benefit from Face ID in iPhone X to release and authenticate no matter wearing a hat, placing on glasses, and developing a beard. TrueDepth Camera, in addition, uses a flood illuminator to perceive a user’s face thru invisible infrared light while it is inadequate mild.
Despite identifying exclusive appearances of the equal person, Face ID in iPhone X still does not permit some other folks who unlock the cell phone. While unlocking the iPhone X, a user has to preserve his eyes open. If the user’s eyes are closed, the iPhone X will stay unlocked. The characteristic makes it hard for unauthorized customers to release the cellular device whilst the authentic user is snoozing or absent. However, Face ID in iPhone X lacks the capability to perceive identical twins. A user has to apply a passcode moreover to prevent his iPhone X from inaccessible to the twin.
No Option to Register Multiple Users
Apple, in addition, complements the safety of the iPhone X with the aid of permitting every user to sign up an unmarried face. No consumer has the choice to check in more than one face. Hence, the simplest one consumer can free up and authenticate thru the Face ID. However, a user can nevertheless make his iPhone X handy to more than one customer via sharing his passcode. Multiple users can get entry to the equal iPhone X by means of appearing authentication through passcode rather than Face ID.
Performs Multiple Tasks
In addition to keeping the iPhone X cozy, Face ID also improves a person’s enjoyment by performing some primary obligations. The interest-aware nature of the facial reputation machine, in addition, allows customers to carry out primary obligations sincerely by means of searching closer to the iPhone X. For instance, a person can take advantage of Face ID to check messages and notifications, the lesser extent of alarm or ringtone, and keep the display screen lit while analyzing.


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Post by doctorawesomesauce on Apr 9, 2016 21:36:21 GMT -7
I went shopping today, and they didn't have the book I needed, but I did find two wonderful clumps of dead tree particles bound together. I already had a couple of the Mars books, but this copy's better because it's one giant book.
One day I'll have a gigantic library of hardcover books. ;-;
Ah, hm, maybe some 'light novels' would be better for them, then? ^^
I do miss books, though. Had wayyyyy to many (and yeah, that can be a thing << ) donated a lot of them because they got in the way. Made some people happy, hopefully. Now I only have a handful left. Mostly Terry Pratchett novels and a few Christopher Moore books. All softcover XP. Probably went overboard with the donating, but it was the only way to prevent, uh. "Oh no, not this one, I still read that one ..." even though, if anything, that would only be true once every 1000 years when the planets aligned, and all that. Hehe.

domain: library


QUETTA: Commander of the Southern Command Lt Gen Asim Saleem Bajwa has said that the use and trade of narcotics have no place in Balochistan.
Speaking on the occasion of burning of narcotics in an official ceremony jointly organised by the Anti-Narcotics Force (ANF), Excise Department, Frontier Corps and Pakistan Railways in Quetta, Lt Gen Bajwa said that the use of narcotics by the youth was dangerous and could destroy their future.
Narcotics control: Senators urge stricter laws against drug smugglers
“We will not allow the use and trade of narcotics among the youth. The law enforcement agencies are following zero-tolerance policy in this regard,” he said.
He said that the security forces did a great service to the nation by seizing and destroying such a large quantity of narcotics. It was a great success on the part of the security forces, he added.
“The forces have saved scores of families from complete destruction,” said the commander, Southern Command.
The security forces recovered 110 tons of hashish, 55 tons of opium and nine tons of morphine, besides destroying poppy cultivation over 128 acres.For the first time after many years, poppy cultivation had been attacked and destroyed.


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With all their talk of kings and queens, and their heavy themes of immorality and revenge, the works of Shakespeare often come off as highbrow. But "Shakespeare is dirty," assures Crystal Carter, director at Theatre 'd Art.
So while you might not initially expect to see one of the bard's works in a TdA season, Troilus and Cressida actually suits the avant-garde troupe just fine. A lesser-known and rarely produced Shakespeare play set during the Trojan War, it's "considered a problem show," the 29-year-old Carter adds. "Lots of people consider it impossible to stage."
"This is the bitter, nasty, human version of a lot of his plays. This is sort of the realist side of Shakespeare," says Carter of the tragedy, which follows the disintegration of Troilus and Cressida's passionate love affair.
Many people believe Shakespeare wrote it when he was heartbroken, and that's why he seems to sabotage the famous royal characters, depicting them as lazy, buffoonish and vain. Achilles is even portrayed as gay.
"What's the worst possible way [in that time period] they could sabotage the greatest warrior in the world in history? They make him ridiculously proud, and they make him gay," says Carter.
People might consider that portrayal outlandish or even offensive, but in Shakespeare's time, it was downright unheard of.
Other themes are more contemporary; for instance, the play addresses issues like idealism versus cynicism, gender issues, homosexuality and the futility of war.
"The outlook of the play is super-modern for what people might think Shakespeare would be," says Jonathan Margheim, the 30-year-old co-founder and co-artistic director of TdA.
It makes for a show challenging not only for audiences, but the actors as well. They're keeping the Shakespearean language, for one thing. But the plotline also poses a challenge.
Instead of a classic Romeo-and-Juliet romance, you get a love triangle and confusion. Instead of a hero's tale, you get an unfinished conquest.
"Most people just don't think it's very satisfying," says Carter. "You have a lot of these arcs that just don't end the way that they would normally."
That helps make this play perfect for TdA. "It's the Shakespeare that's written for entertainment," says Carter. It's ripe with crude humor and gore, which is also what makes it fit in with the rest of the season.
"I was looking at an interesting season of blood," says Margheim. When planning TdA's season, he chose plays that featured violence in its different forms, from exploitation, to psychic violence, to outright violence, to the futility of violence in war, as found in Troilus and Cressida.
Plus, he says, "Bloody shows are always fun and cool."

domain: entertainment


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This recording was made near the small town of Singleton in East Texas. The region is a pine forest and this breeding plumage male was singing from the top of a mature pine tree. There were many other males of this species singing in the area. The original recording is now archived at the Dudley T. Dougherty Natural Sounds Collection in Normanna, Texas.
Equipment was a Panasonic SV250 cassette recorder and a Sennheiser ME88 microphone.
Robert Benson, XC210725. Accessible at www.xeno-canto.org/210725.
|Location||Singleton, Grimes County, Texas|
|Sampling rate||48000 (Hz)|
|Bitrate of mp3||146172 (bps)|
|Number of notes||Not specified|

domain: geography


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A chimney fire that spread to a roof caused about $10,000 in structural damage to an area home on Thursday night. Freddie Taylor, the owner of 3212 Shady Valley Drive, was home on Thursday night burning wood in his fireplace. It wasn’t until a neighbor came
Junction City police on Wednesday arrested one of the victims in a Sunday shooting. Jackie Oliver, 42, Junction City, was arrested on the charge of aggravated battery in connection with a shooting incident on Sunday at 805 Grant Ave. He is currently confined on a $25,000 bond at
A man approached two 12-year-old students between 2:50 and 3 p.m. on Tuesday as they were taking items to the recycling trailer at St. George Elementary School. One of the students believes the man had questionable contact with him inside the trailer and may have been
The Kansas Department of Labor is investigating the death of a Manhattan city worker after a dirt trench collapsed on him on Friday. William Wiske, 30, of Wamego, died from the injuries he received after he was buried up to his waist in dirt and mud.
Riley County police identified the victim of a shooting death on Monday as 46-year-old Steven Hoard of Randolph, according to a press release issued on Tuesday afternoon. The RCPD responded to the 14000 block of Gardiner Road in Randolph around 1:20 a.m. and declared Hoard dead.
A suspicious tube that contained homemade fireworks was removed from the overpass of Seth Child Road over Kimball Avenue on Tuesday morning. The RCPD and Manhattan Fire Department responded around 8:40 a.m. after someone saw the package in the road and filed a complaint. The
Riley County police seized more than $171,000 worth of drug-related items and arrested four people last week while serving a series of search warrants. According to a press release issued by the Riley County Police Department, items seized include $51,000 in cash, 14 pounds of marijuana, 1/2 pound of
A search warrant on Thursday helped lead to the arrest of three people who vandalized buildings in Manhattan, Kansas State University and Pottawatomie County. Since October 2014, more than 25 buildings have been vandalized with spray paint. Riley County police estimate damage in excess of $15,000. The graffiti
Junction City police say they are investigating a Sunday morning shooting that sent two men to the hospital. Police responded to the parking lot of The KINGZ Motorcycle Club, 805 Grant Ave., shortly before 4 a.m. and discovered Jackie Oliver, 42, suffering from two gunshot wounds, according
A three-vehicle crash in Wabaunsee County caused injuries to three people on Sunday. According to the Kansas Highway Patrol, the crash happened at 4:12 p.m. when Ronald M. Stos, 64, of Great Bend, who was driving his 2011 Ford Taurus westbound on I-70 near mile marker 328, didn’
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The Department of Biochemistry Henry I. Russek Achievement Day Awards Committee is pleased to announce this year’s award winners. Nathan Kingston [Dr. Xaralabos (Bob) Varelas’s lab] is the first prize winner, and Joseph Kern [Dr. Xaralabos (Bob) Varelas’s lab] is the second prize winner. Our congratulations go out to the winners as well as their advisor! We look forward to hearing about their work on Henry I. Russek Achievement Day; remember it’s this week (Thursday, May 6th and Friday, May 7th) so mark your calendars for the virtual events.
The keynote address will be delivered on Thursday May 6th at 9:20 AM by Dr. Daniel Haber, Director of the MGH Cancer Center, “Circulating Tumor Cells: Insights into Cancer Metastasis”. Please go to the following site for updated information and to register so as to get the Zoom link:
A recently published study from the Varelas laboratory has identified new mechanisms contributing to the development of precancer lesions in lung airways. Precancer lesions that arise in airways are associated with chronic lung damage, such as that induced by cigarette smoke, and such lesions are predisposed to transitioning into lung squamous cell carcinoma, a poorly treatable subtype of non-small cell lung cancers.
The study shows that disrupted epithelial polarity leads to airway epithelial stem cell expansion, resulting in pathologies that resemble human precancer. Aberrant epithelial polarity was induced by the conditional deletion of the polarity regulator Crumbs3, which the group showed leads to activation of the transcriptional regulators YAP and TAZ. The study showed that YAP/TAZ-regulated gene expression drives a gene expression program that stimulates epithelial plasticity and stem cell growth, and associates with the progression of precancer lesions in human patients. Through analysis of YAP/TAZ-regulated genes, an important role was uncovered for the growth factor Neuregulin-1, which is directly induced by YAP/TAZ and stimulates signaling via the ERBB-receptors. Notably, the study showed that inhibition of ERBB receptors was capably of preventing and treating precancer lesions in polarity-defective animals.
The study, which was published on April 26, 2021 in PNAS, offers new knowledge into the etiology of lung precancer pathology, and provides directions for identifying and intercepting lung squamous cell carcinoma at the earliest stages.
The Center for Biomedical Mass Spectrometry (CBMS) has been awarded a grant by the Massachusetts Life Science Center to advance the ability to characterize spike protein glycosylation as respiratory viruses evolve. The CBMS applies mass spectrometry methods to meet the emerging needs in biomedicine. As part of this award, CBMS has just installed a new Waters SELECT SERIES Cyclic IMS system. The Cyclic system represents a breakthrough technology that will facilitate rapid and accurate characterization of virus spike protein glycosylation to support virus surveillance and vaccine development.
Respiratory viruses including influenza and coronaviruses evolve rapidly as they circulate in the human population. These proteins are coated with a spike protein that recognizes receptors in host airway cells. Spike proteins are decorated by sugar molecules known as glycans. These glycans enhance the structures and functions of proteins, including the virus spike proteins. Researchers track the genetic sequences of viruses as they evolve. The genetic sequences do not predict the manner in which glycans alter the structure and function of virus spike proteins.
The Garcia-Marcos laboratory has discovered that heterotrimeric G-proteins, which are critical molecular switches in cellular communication processes, can trigger different responses in cells depending on the type of protein that activates them.
Heterotrimeric G-proteins are typically activated by G-protein-coupled receptors (GPCRs), which are the target for over one-third of drugs approved for use in the clinic. But G-proteins can also be activated by other proteins that are not GPCRs, a mechanism with important implications for human physiology and disease. The Garcia-Marcos laboratory has used an innovative approach to dissect and compare the consequences of G-protein stimulation by different activators, including GPCRs and various non-GPCR proteins. The approach leveraged a recently developed type of biosensors capable of detecting different forms of active G-proteins in living cells in real time. These were combined with engineered G-protein activator constructs that could be turned on at will with an exogenous synthetic chemical.
The main conclusion is that, contrary to previous beliefs, GPCR and non-GPCR activators elicit different forms of G-protein activation in cells. These findings have important implications in our understanding of pharmacologically actionable signaling hubs in cells, which could be leveraged to envision and design new therapeutic agents.
You can read the article here:
Garcia-Marcos M. Complementary biosensors reveal different G-protein signaling modes triggered by GPCRs and non-receptor activators. Elife. 2021 Mar 31;10:e65620. PMID: 33787494 https://pubmed.ncbi.nlm.nih.gov/33787494/
Robert Mercer, a Postdoctoral Associate in the Harris Lab, was recently awarded a Discovery Award research grant funded by the Department of Defense. This two-year, $200,000 grant is entitled “ Identification of Receptors for TAR DNA-binding Protein 43 (TDP-43) That Mediate Cellular Uptake and Neurotoxicity ”. This project aims to identify the cellular receptors of the pathological TDP-43 assemblies found in the brains of patients with Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Lobar Degeneration (FTLD), and Chronic Traumatic Encephalopathy (CTE). The identification of these receptors will provide novel therapeutic targets to combat these devastating and currently untreatable diseases.
Dr. Alla Grishok, Associate Professor of Biochemistry has been awarded a 2021 Shipley Prostate Cancer Research Pilot Grant Award. She will act as coordinator of a multi-center, multi-PI initiative involving Dr. Christopher Heaphy (Department of Medicine), Dr. Joshua Campbell (Department of Medicine), and Dr. Rachel Flynn (Department of Pharmacology and Experimental Therapeutics, GSI) across Boston Medical Center (BMC) Pathology department, Shipley Prostate Cancer Research Center, BU-BMC Cancer Center, and Genome Science Institute (GSI) at BUSM.
The goals of this pilot research are: "to (1) identify coding and non-coding genomic alterations that are associated with more aggressive disease in Black men with prostate cancer and to (2) establish a pipeline that will integrate the genomic data with other biomarker measurements, such as the presence of circulating tumor DNA or alterations in the gut microbiome, and with the overall clinical outcomes in a large cohort of men". The success of this project may lead to better predictions of the severity of the disease in individual men and to informed selection of the appropriate treatment options in the future.
Most cell surface and extracellular matrix proteins are glycosylated as a mechanism driven by evolution that elaborates their adhesive interactions with binding partners. Such glycosylation occurs by biosynthetic reactions in the secretory pathway that gives rise to heterogeneity at each glycosylation site. This heterogeneity diversifies the range of interactions and therefore functions of glycoproteins. But, how can we understand the functional roles of glycoproteins if they are heterogeneous? Conventional proteomics methods have been adapted to quantify protein glycosylation heterogeneity, but understanding glycoprotein function requires improvements in sensitivity and selectivity. Chang and Zaia describe current methods of glycosylation quantification and show the promise of emerging glycoproteomics methods that employ data-independent analysis and ion mobility separations.
Ladan Amin an Instructor in the Harris laboratory was recently awarded a R03 research grant, funded by the National Institute on Aging (NIA). This two-year, $200,000 grant is entitled “Use of super-resolution microscopy to visualize the interaction between Alzheimer therapeutic antibodies and Aβ aggregates”. This project aims to identify the molecular mechanism of action of several different clinical antibodies by localizing them on single Aβ aggregates. This information will contribute significantly to understanding the basic biology of amyloid and its role in Alzheimer’s disease, and will provide a fuller picture of molecular mechanisms responsible for detoxifying oligomers and enhancing their clearance.
The Dr. and Mrs. Franzblau Travel Award Committee is pleased to announce the winners of this year’s Myrna and Carl Franzblau Student Travel Awards. We had many deserving applications this year and were able to provide awards to four PhD students and four Postdoctoral Associates within the Department. The recipients and their advisors are listed below:
- Joe Kern (Varelas)
- Addie Matschulat (Varelas)
- Jarrod Moore (Emili)
- Matt Lawton (Emili)
- Tara Liyanage, Ph.D. (Costello)
- Nachen Yang, Ph.D. (Lau)
- Robert Mercer, Ph.D. (Harris)
- Zheng Zhu, Ph.D. (Lau)
These awards are made possible by the generosity of Dr. and Ms. Franzblau and will provide funds to defer the costs of travel for these trainees to present their research at a national/international scientific conference. This year’s award selection committee was comprised of members of the Biochemistry Department Dr. and Mrs. Franzblau Travel Award Committee (Barbara Schreiber (chair), Alla Grishok, and Steve Farmer). The Department thanks the selection committee for their careful consideration of all the applicants.
A new review by first author Carlos Perea-Resa in the Blower lab was recently published in Trend in Cell Biology (Cohesin: Behind Dynamic Genome Topology and Gene Expression Reprogramming)
In spite of sharing the same DNA molecules, cells in our body show different shape and function as a consequence of differential gene expression. Studying how cells organize and read the instructions contained in the DNA is essential to fully understand organism development and the etiology of developmental diseases. A growing body of studies evidence the central role of the cohesin complex in both, organizing and reading genomic information. In this review published at Trends in Cell Biology, this article revises the most recent literature about how cohesin regulates gene expression. The article pays special attention to the role of cohesin in cell shifts across different stages of the cell cycle and during cell fate determination events in development. They also propose a scenario to explain the molecular etiology of Cornelia de Lange Syndrome, a developmental disease caused by cohesin disfunction on gene expression regulation.

domain: biology


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Dating rumours of BIGBANG’s G-Dragon and former f(x) member Sulli have been circulating on the net since the latter’s breakup with Choiza, but their labels have slammed them.
In press statements released today (Thursday, 16th March), the companies denied that the 2 are romantically involved.
YG Entertainment slammed the rumours as ridiculous, expressing, “G-Dragon is currently preparing for his solo album and is focusing solely on that. He hasn’t seen Sulli since they met each other at the amusement park.”
They continued, “Because of the recent rumors concerning G-Dragon and Sulli on the internet, we asked him personally. G-Dragon said it was ridiculous. The rings G-Dragon and Sulli have been pictured wearing were gifted by an acquaintance they both know.”
A source close to G-Dragon exclaimed that the singer laughed off the rumours when he heard it, saying that it was crazy and groundless.
Meanwhile, SM Entertainment also released a straightforward statement, explaining, “The dating rumours between G-Dragon and Sulli are not true.”
Earlier in February, the 2 were spotted hanging out together at Lotte World, an amusement park in Korea. Brown Eyed Girls’ Ga In and former KARA member Goo Hara were also present.
G-Dragon was initially linked to Hara, as Sulli was dating Choiza then and Ga In is in a relationship with actor Joo Ji Hoon. However, Hara’s side shot down the rumours immediately, reiterating that the 4 are close friends.
Netizens then began to suspect that the BIGBANG leader and Sulli was dating, citing their “couple ring”, similiar selfie angle, and art photos.


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The latest insights on the journey…
It's almost five o'clock. I want to sit in front of the TV and forget about how I feel. I want to avoid doing the things I know are worth even only five minutes of my time. Because it takes strength and willpower. Both of which feel like they're hitting new lows. New...read more
When I wake up in the morning and the living room is blue from a sun yet to rise over the tops of surrounding buildings I sit crossed legged and close my eyes. I take a few deep breaths and draw my attention over every inch of my body as my breath permeates each cell....read more
When the rock bends the road and the tall grasses reach to meet it Eons in time spill across space whose dark edge sinks to meet the horizon, whose stars and moons cast a light and deep shadows that go unnoticed this time. It’s the splattering of pebbles and stones...read more
At the top I see out across the landscape, a scene obscured. Deep clouds fog the view and yet - I know that great expanse. The endless horizon of my consciousness, infinite and unknown. I breathe in with great pause. In my chest I feel the rest as I settle in my...read more
Grieving for the Earth Today is the day I share with you my grief for the earth. If you don’t see it, then it’s time to. Take a look. See the trash that litters the highway. See the shredded plastic bags that cling to trees along creeks that run with oiled waters. See...read more
When You Change Relationships Change A few months ago I set out with the intention to write and share regularly on social media. This was big for me because I hadn’t ever posted regularly. And when I did post it was hardly ever anything of substance. It was mostly...read more
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domain: literature


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You may have seen that internet dating is normally bad for folks. This is a great oversimplification, but there are several causes it certainly is not. Listed below are only a couple of reasons. Deciding on between too many options can be demotivating. For example , you might end up bypassing the quickly pull aisle entirely if perhaps there are a lot of flavors of quickly pull. Similarly, so many choices can cause you to feel raced and overcome.
The average male with an online dating website incorporates a profile that looks similar to this of the common straight man. In fact , 30-40% of profiles will be identical. Consequently, you might have helping put in some extra hard work if you want to get noticed. That means you simply must put in even more effort than most ladies. On the other hand, if you would like to get the right woman, you will have to commit to the whole procedure.
Featuring personal data is another common risk. In an study by Columbia Writing Investigations, a study of more than you, 200 women of all ages revealed that almost a third of these females had skilled sexual breach after interacting with someone that they met via the internet. It is critical to protect yourself and the information you provide to other people, particularly if it comes to photos. If an individual sees a photograph of you, they can use it to blackmail you.
Another reason as to why online dating is usually bad for fellas is that men use it to jump on the dating game when they are done with a relationship. However , even though these females are more assertive and outgoing than the average woman, they still have the power to condition the speed and termination of a romantic relationship. The risks will be high with regards to both parties. It may seem like an inconvenient truth to some, but these points will help you make an informed decision.
Online dating services is a amounts game. Research have shown that only 4% of on-line messages are actually responded to by simply women. Messages that read “Hey” aren’t effective. Men should send icebreakers or copy & substance to dozens of ladies to increase their chances of accomplishment. These methods may take a while, but they can pay off. The only problem with online dating is that women can get frustrated with the incapacity to contact you.
One more online dating is bad for fellas is the deficiency of attention they will receive. According to a recent survey by the Pew Research Center, men https://bestmailorderbrides.info/blog/places-to-find-wife/ are less satisfied with the attention they will get on seeing apps than women. The quantity of messages directed per week is also higher than women of all ages. And guys who are becoming the attention they want is also below what women acquire on off-line dating. A high level00 man and want to get yourself a woman on an online dating site, you should stop harassing her on the internet.
The worst thing someone can carry out to attract a girl is to own a boring account. Women will be drawn to https://www.spectrum-agency.com/ certain features, such as intellect, a readiness to take hazards, and so on. A boring profile is actually a kiss of fatality when it comes to online dating services. You must ensure that you portray these kinds of traits in your profile. https://pesticideinfo.blogactiv.eu/2019/08/20/no-fuss-advice-for-find-a-girl-uncovered/ If you want to draw women, be sure to demonstrate to them how you embody these attributes.

domain: sociology


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This title captures the spirit of this beloved story with his folk art inspired characters.
Noah may not have had detailed plans when he set out to build the Ark, but readers will learn how to carve a beautiful 19 piece Noah's Ark set with well-known carver Shawn Cipa.
At the heart of the book are projects beginning with detailed plans for building the Ark.
Step-by-step carving and painting instructions are included for Noah and the lion.
Detailed patterns followed by photographs and carving tips are included for Noah's wife and 15 types of animals.
Many animals featured in the book are presented in two positions (to create the pairs of animals aboard the Ark).
- Format: Paperback / softback
- Pages: 160 pages
- Publisher: Fox Chapel Publishing
- Publication Date: 01/09/2011
- Category: Carving & modelling, moulding & casting
- ISBN: 9781565234772


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The native PlayStation 5 version of Resident Evil 3 may not be too far away from release as it's been spotted the PS5 is recognising the free PS4 to PS5 upgrade path after inserting the disc. Spotted by Twitter user BSAAEurope, the console asks if you want to upgrade the PS4 version of the game to the PS5 one, but the link to the download isn't live just yet.
This may suggest the PS5 version of Resident Evil 3 will launch in the near future, with native versions for Resident Evil 2 and Resident Evil 7: Biohazard on Sony's latest system also set to follow this year. All three titles will be treated to visual enhancements on PS5.
While we considered it a "competent remake" at the time, it's hard not to look back on Resident Evil 3 as a disappointment. After cutting so many of the PS1 original's iconic locations, the PS4 remake amounted to a very quick trip through Raccoon City as Jill and Carlos. Maybe we can get that original experience back on PS Plus Premium? We'll have to wait and see. For now, we have this PS5 version to look forward to.

domain: game


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Cllr Jane Gracey
I have been co-opted to the Parish Council in 2016. My main motivation for joining stems from seeing and living with many changes in Keyworth over the years. I have experienced life here as a child, teenager and adult, now a parent myself. The village has grown in many ways and I would like to help develop continuing opportunities and facilities for younger/teenage residents as well as the older ones. It is important to me that Keyworth maintains enough community appeal for people to want to live here, without becoming a soulless commuter town.
I attended Crossdale Drive Primary school, followed by South Wolds Secondary as a child. My own three sons have done the same; one is still at Crossdale, one at South Wolds and one is now at University. Over the years I have had lots of input with the schooling and leisure activities around Keyworth, particularly the Keyworth Scouts where I have been a helper. I am keen on swimming and cycling and do these as often as I get chance.
For work, I help families to cope with their loved ones who have dementia. I work across Nottinghamshire and am helping to expand the services available.
I also work as a call handler for the ambulance service in my spare time.
I am available to contact by email : firstname.lastname@example.org


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Psalm 34:8 Taste and see that the Lord is good;
blessed is the man who takes refuge in him.
Virtually every verse of this Psalm is underlined, in both languages, in my bilingual Bible. I could write on any part of it! It strikes me that this Psalm is a personal testimony of David. The preface indicates that he wrote it after the Lord gave him the wisdom to escape a potentially very dangerous situation. Rather than take credit for that escape, David praises God and recommends Him to all who will listen. That is the essence of personal evangelism. There are all sorts of “canned presentations” for evangelism out there, but none are very effective even in countries with a Christianized culture, and far less so in places like Japan. Every believer needs to grow past the point in their faith of what’s in it for me, but in all honesty, that’s how most people make the first step. David is saying, “Have a taste. God is the best thing ever!” Actually, David used a specific framework for this testimony, starting each verse with the successive letters of the Hebrew alphabet, so that shows us the utility that things like The 4 Spiritual Laws tract can have. However, the framework by itself is nowhere near as effective as when it is backed up by personal experience. “God met my need, and He’ll meet yours too, if you will let Him.”
I well remember my frustration in Personal Evangelism class in seminary, realizing how ineffective what I was being taught would be in Japan. The professor was a marvelous man and a very effective evangelist in the American context, but I knew his techniques wouldn’t make the transition to the Japanese context. When we finally got to Omura, after graduation and serving in a church in Virginia for two years, I told people I wasn’t here to teach a religion, but to introduce a Savior. (There’s a pun in that in Japanese.) I grasped the reality that nothing would be as effective as sharing what God had done for me, but my background was totally different from those I was speaking to, despite my having been born and raised in Japan. Not only was I from a strongly Christian family, my schooling was American, having attended the dependents school of Itazuke Air Force Base. After seeing my own daughters’ experiences in Japanese schools, I have come to the conclusion that the major purpose of Japanese schools is to make people Japanese, instilling culture and even thought patterns into them. (America would be a more effective “melting pot” if US schools did more of that, but that’s a different discussion.) On top of that, I am Caucasian, which automatically makes me “other” to practically everyone I meet, so they don’t see my experiences with God as having any relationship to them. That makes me a far more effective Bible teacher than evangelist, which itself is fine with me, but I need to inspire the Japanese believers to share Christ with their family and friends, since they don’t have the barriers I do. That’s not easy either, because I can’t really teach by example. However, people do get saved, and it’s almost always from their seeing someone who is living out their faith in a personal relationship with their Lord. That is something to rejoice over!
Father, thank You for this reminder. I do pray for the sister who will be here next week from America, desiring to win her parents and sister to Christ while she is here. Thank You for the openness her mother has expressed. I pray that Your Holy Spirit would have free rein, that we may see a marvelous harvest in Your kingdom, for Your glory. Thank You. Hallelujah!


Thoughts on Jed Lowrie
It’s quite clear this season hasn’t gone the way Lowrie hoped. Entering last night’s game he owned an 87 wRC+ and a .235/.320/.343 line on the year with a .262 BABIP, nearly 30 points below his career average. Good things come to those who wait, at least that is something I was once told, and after three months of waiting, Lowrie has finally begun to reward his fantasy owners. Including last night, Lowrie has put together a seven game hitting streak with six multi-hit games. The brilliant and handsome Blake Murphy broke down what a great buy Lowrie could be in the second half and I agree. He is available in 30% of CBS formats as well as over 40% of Yahoo! and ESPN leagues.
Kevin Gausman to start tomorrow
The 23-year-old Gausman will face off against the visiting New York Yankees in what will be his seventh big league start of 2014. The Baltimore Orioles called him up in order to take Ubaldo Jimenez‘s slot in the rotation. Jimenez is hitting the 15-day disabled list due to a sprained ankle and Gausman figures to be up with the O’s until Jimenez is deemed fit to pitch. Baltimore manager Buck Showalter noted it was the same ankle Jimenez sprained back in 2012 and that the club will look at Jimenez’s injury history when evaluating him. Gausman is a solid match up guy tomorrow given the Yankees’ 20th ranked 91 wRC+ against right-handed pitchers. I don’t love Gausman’s control — 3.74 BB/9 this year in Triple-A — but a fastball with an average velocity of 95 mph allows you to miss a few spots here and there. For now I’d feel most comfortable streaming Gausman or maybe rostering him in deep leagues. One can grab Gausman in 90% of ESPN and Yahoo! formats as well as 60% of CBS leagues.
A pair of NL West outfielders return
The Colorado Rockies welcomed Carlos Gonzalez back to the field yesterday evening. Though he only recorded one hit on the day, CarGo did make a very impressive throw to gun down Brian Dozier at third base. Without retreading on the same “great-if-healthy” lines so many already have, I’ll just say that I love watching CarGo play. He has power, speed and when tested, his arm never fails to impress me. With a .292 BABIP a good 50 points below his career average, I’d love to buy low on him right now. Of course, any owner who has stuck with CarGo on the DL for over a month probably isn’t looking to sell, but it is worth a shot.
In a fight to avoid last place in the NL West with the Rockies, the Arizona Diamondbacks activated Mark Trumbo from the 15-day DL prior to yesterday’s game. The slugging outfielder has been out of action since April 22 due to a stress fracture. His rehab performance indicated he was ready to go, as five home runs and a .458 batting average in seven games is impressive. By now Trumbo is a pretty well known commodity: power and more power. Prior to his injury he was tied for the league lead in home runs and before the season started I was very high on him in a hitter friendly park like Chase Field. I still think he is capable of posting big numbers in the second half of the season and like CarGo, in the unlikely event that Trumbo’s owner is willing to sell, grab him.
The daily five
Starting pitcher: Mike Minor — $8,000
While the Chicago Cubs hit southpaws fairly well — their 103 wRC+ ranks 11th — they do own the highest strikeout rate against them at over 25%.
Starting pitcher: Adam Wainwright — $10,800
After going through options like Wade Miley against a San Francisco Giants team that blasts left-handed pitching or Jake Odorizzi squaring off versus the Toronto Blue Jays, going with Waino was more expensive, but worth the money.
Infielder: Juan Francisco — $3,500
The left-handed swinging corner infielder is up against a solid pitcher in Odorizzi, but Francisco punishes opposite-handed pitchers to the tune of a 149 wRC+.
Outfielder: Christian Yelich — $4,500
Yelich will hold the platoon advantage over Daisuke Matsuzaka. I’d look for Yelich to earn a walk or two and hopefully hit a dinger, as all seven of his long balls have come against right-handed pitchers.
Other hitter: Jose Abreu — $5,200
Wicked power, man. The right-handed swinging Abreu faces off against Zach McAllister today, also a righty. Thus far in his short career Abreu has actually hit same-handed pitchers better than southpaws, and I expect a big day from him today.
Remaining budget: $18,000
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The DTS Technology Advisory Board has recently awarded UGRC an innovation grant of $25,000 for the Digital Assistant Skill for Voting Project.
The goal of this project is to make voting information more accessible to Utah citizens and, ultimately, increase engagement in the voting and political process. This effort aligns with the Innovation Fund’s mission to support projects that promote a “greater efficiency in a government process or a cost saving in the delivery of a government service, or both” (2018 General Session, H.B. 395, Technology Innovation Amendments).
UGRC’s proposed voice-enabled digital assistant project can benefit several Utah entities, especially the Lieutenant Governor’s Office, the Department of Workforce Services, and county clerks’ offices. It will also provide an opportunity for cross-agency collaboration. But just as importantly, this service aims to increase Utah citizens’ engagement in the voting process.
Official voting information is currently available to Utah citizens through the vote.utah.gov website, but UGRC’s innovation fund proposal suggests that this information be made available through Amazon Alexa devices and Google Assistant devices. The new voice-enabled digital assistants will provide a voice-based user interface design and natural language processing, along with machine learning and artificial intelligence cloud services.
The voice assistants could also answer simple questions, as well as provide resources to answer more complex questions, more effectively and efficiently than users looking up information on their own. This will also help other agencies save time since they’d, hopefully, be fielding fewer calls about voting questions.
Work on this new project will begin immediately.

domain: news


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Dr. Russell Wm Simpson, MD
4896 Chambers Rd, Denver, CO 80239
No coupons available
08/04/2011Provided by Citysearch -
I was a long time patient of that office and I have seen office staff come and go doctors come and go now there is only Jennifer working there she is the only good one there. Kathy who claims to run the office yea what a fat joke she doesn't know the first thing about her job. I have heard her staff talk about her. I have also seen her previous staff at new jobs and they are much happier at their new postions. I have heard her talk to patients using cuss words in front of little children in the waiting room. You can no longer get a return phone call. I called for Jennifer one week straight everyday and never got a return call and then on my appt day, Jennifer told me she has never recieved any of my messages. Dr Nash did not even finish his two weeks he just left. So what does that tell you about this office. Get rid of Kathy and maybe you might have doctors and staff that want to stay just because you are married to the doctor/owner does not make you the office manager Kathy. Also because you you are married to the doctor does not give you the authorization to make the calls of doctors go to college and get your MD degree first.
03/06/2011Provided by Citysearch -
This is a great clinic who gets to the bottom of the patients well being and what maybe going on. Dr.Simpson has 3other awesome very skilled physicians who'll see and treat you in one visit for more then one problem/illness you may have had or have. They run tests, refer you out for x-rays, ultra sounds whatever it takes to get to the bottom of a patients health. They do the paperwork, they take care of their patients unlike some offices who don't want to deal with paperwork overload, in checking further in what they maybe missing that the patient is complaining of. Dr.Jennifer and John-Paul are pretty fast if you don't want to wait to long with Dr.Nash right behind them. The only reason Dr.Simpson maybe a bit of a wait is because he also works at PSL and is back and forth between locations. These patients have no idea how fortunate they are to have such a clinic, doctor's in there area as such! Behind the scenes, they really look into what can help their patients well being, their illnesses. Order is what this clinic definitely has and it all starts from great management, great employees. If you want to get in and out, Jennifer is pretty quick and still thorough, not that the others aren't as well.
01/03/2009Provided by Citysearch -
The wait in office can go into hours. It does'nt matter if you have an appointment you will be waiting a long time regardless.The appointment availibility is pretty tough. If you need an appointment soon don't count on it. The followup with its doctors is nonexistant.. Don't expect any such thing.

domain: medical


Apkmodsios.com Wistron could not produce high-end iPhones for the Indian market in spite of everything Wistron might not be shifting to provide Apple’s high-end iPhones in spite of everything, a report claims, suggesting that regardless of the elevated Apple-centric funding in its manufacturing amenities in India, it is going to be for a wider vary of system manufacturing as a substitute of the more-expensive iPhone fashions.
The iPhone 6s, certainly one of two iPhone fashions produced by Wistron in India
Latest reviews regarding Apple meeting companion Wistron indicated a rise in funding was underneath manner, with $340 million being poured into increasing crops within the nation, together with people who produce iPhones. The expansion in assets included an enlargement of manufacturing capability on the Narasapura plant, with the primary part anticipated to finish within the first half of 2019.
In early March, Indian IT minister Ravi Shankar Prasad confirmed a plan to spend 5,000 crore ($714.6 million) within the nation had been accepted by the data expertise ministry, with Prasad suggesting strongly it was to do with iPhone manufacturing. “Wistron will make the most recent iPhone fashions,” boasted Prasad in an interview, although on the time neither Wistron nor Apple confirmed this was the case.
Unidentified business insiders talking to the Enterprise Commonplace deny plans are underneath manner for Wistron to assemble the higher-end iPhones, which might have been a step up from its current actions making the iPhone SE and iPhone 6S for native sale. The brand new amenities being invested in by Wistron are touted to make Apple merchandise, however is seemingly going to provide a “wider array” of Apple units, and never gadgets just like the iPhone XS or iPhone XS Max.
The feedback by Prasad are dismissed within the report as “nothing however election-time rhetoric to showcase funding.”
Whatever the fashions being produced, the funding will assist Apple take care of a native sourcing subject, the place it requires to import a substantial variety of iPhones to the nation to satisfy demand that native manufacturing is not presently reaching.


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We are pleased to announce the launch of Roberts Wineware’s newly designed website: www.robertswineware.com.
Since our conceptualization, we have redefined the way wine is consumed. Wine is a sensual pursuit. Our wine glasses not only reflect this, they enhance it. We don’t mean to gloat, but that is no easy feat. We believe our website also should reflect the quality of our glassware: beautiful, elegant and easy to use.
Check out some of our favorite features:
Our glassware is more than a glass...it’s an experience. With our new Shop section, we are redefining your shopping experience, from start to end. Learn what goes into the design and technology of our glassware as you browse our products.
Our Supertaster wine glasses have Taste Stimulating Textures ™ on the outer glass to provoke the neural receptors on the tongue, encouraging saliva to flow, thus altering our bodies to register enhanced sensations associated with taste and flavor recognition. While this is a complex process, you can now explore our Technology tab to understand our trademarked technology responsible for transforming your experience.
At Roberts Wineware, we believe that glassware should not only be beautiful, but also heighten the perception and pleasure of each wine through the sense of touch. That is why we are devoted to crafting a timeless and superior design. Through texture, well-proportioned bowls and sensuous stems, we are able to achieve “a better wine glass.” Check out our Design tab to learn more.

domain: design


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Why there are so many COVID-19 cases, hospitalizations in the Northeast
The Northeast has the highest proportion of estimated cases linked to XBB.1.5.
As COVID-19 cases and hospitalizations rise across the United States, the Northeast is being hit much harder than other regions of the country.
States including Connecticut, Massachusetts, New Jersey, New York and Rhode Island have some of the highest weekly case rates per 100,000 in the nation, according to data from the Centers for Disease Control and Prevention.
What's more, while seniors across the U.S. are being hospitalized at a rate three times higher than other age groups, it's five times higher in the Northeast, CDC data shows.
Public health experts said the reason for the rise is multi-factorial and includes the spread of more transmissible variants, a higher proportion of elderly people and not many Americans receiving the updated bivalent booster.
Spread of XBB.1.5
Not much is known about XBB.1.5. What we do know is that it is an offshoot of the omicron subvariant, which caused a surge of infections during the winter 2021-2022 season.
Early research suggests it may be better at evading immune responses and, recently, the World Health Organization said it was the most transmissible COVID variant to date.
"I think that the primary thing right now that's driving higher rates, perhaps, in the Northeast is the higher proportion of XBB.1.5," Dr. Shira Doron, chief infection control officer for Tufts Medicine Health System, told ABC News. "That's the number one detectable difference between the Northeast and the rest of the country."
CDC data shows that in the U.S. Department of Health and Human Services' Region 1 -- including Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island and Vermont -- XBB.1.5 accounts for an estimated 71.6% of new COVID infections.
In Region 2 -- made up of New York, New Jersey and the U.S. territories in the Caribbean -- it's an estimated 72.7%.
Comparatively, XBB.1.5 makes up an estimated 7.3% of new cases in the Midwest and about an estimated 6% of new cases in the Great Plains region.
Low booster rates
As of Jan. 5, 2022, six of the 10 states with the highest percentage of residents who have received an updated bivalent booster dose live in the Northeast, according to CDC data.
Vermont leads the pack with 31.3% followed by Maine, Massachusetts, Connecticut, Rhode Island and New Hampshire, respectively.
The shot was developed to specifically target the BA.4 and BA.5 variants. It is currently unclear how well the booster protects against XBB.1.5.
"This XBB.1.5, it is an omicron offshoot so there is hopefully some cross reactivity in our antibody and immune responses in those who got the BA.4/BA.5 bivalent booster," Dr. Scott Roberts, an assistant professor and the associate medical director of infection prevention at Yale School of Medicine, told ABC News. "It probably won't be as good as BA.4/BA.5, but it's certainly the next best thing."
Even though the rates are higher in the Northeast than elsewhere in the country, they are still lower than experts would like to see and having less than half the population vaccinated is only so helpful.
"My suspicion is that the transmissibility of XBB.1.5 most likely far outweighs the proportion of people who have gotten the booster," Roberts said. "Even though we are a higher vaccinated region than many other regions of the country, it is still the minority of people in our region who have gotten the bivalent booster."
Higher proportion of older adults
Another reason for the increase in cases and hospitalization could be that the Northeast has a higher proportion of elderly people who are more prone to infection, severe disease and death from COVID-19, experts suggest.
Although the majority of seniors aged 65 and older are fully vaccinated at 94.1%, just 38.1% have received an updated bivalent booster dose, according to CDC data.
Age is a known risk factor and the immune system wanes as a person ages, making them more vulnerable to infection.
"What I think is fascinating is if you look at the top 15 states in each of the 50 states, five of them are in New England," Dr. Leonard Mermel, an infectious diseases expert at Rhode Island Hospital, told ABC News. "Five of the top 15 states with the greatest proportion of the population 65 years of age or older are in New England: Maine, Vermont, New Hampshire, Rhode Island, Connecticut."
"And so, for older folks, you take their waning function their immune system, and not enough Americans getting boosted, and that's problematic," he added.


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Start out 720x90 bnr Draw
Comprehending Asthma attack Medicines (cont.)
On this page
Precisely what are Asthma Drugs in addition to Treatments?
Affected person Thoughts Study a single Opinion
The main aims within asthma attack treatment method are to stop all about asthma episodes as well as control the sickness. Preventing activates that induce or perhaps irritate symptoms of asthma strikes is a vital part of elimination. Medicinal drugs accustomed to keep symptoms of asthma assaults (accountant remedies) target minimizing the respiratory tract redness that triggers assaults. Saving drugs enable wide open your neck muscles and are generally useful for rapid comfort while asthma signs and symptoms appear in spite of the make use of accountant medications.
Many of the inhaler treatments have been improved recently with the federal mandate to clear out chlorofluorocarbons (CFCs) from your devices to try to prevent further more trouble for the environment'ohydrates ozonosphere. These types of inhalers include improved to some brand-new propellent, hydrofluoroalkane (HFA), or powdered units. The following change in distribution program lead unwittingly with removing most general inhalers on the marketplace and only exclusive (brand) options ended up offered right up until recently. The actual FDA accepted levalbuterol like a commonly used for any attempt inhalator named Xopenex. Moreover, medicines is also accessible like a generic with nebulized style together with the taken in steroid budesonide (Entocort, Uceris, Pulmicort).
Corticosteroid Inhalers to get Asthma: Make use of, Adverse reactions, in addition to Affairs
Beclomethasone (Qvar), budesonide (Pulmicort), flunisolide (AeroBid), fluticasone (Flovent, Arnuity), mometasone (Asmanex), in addition to Aristocort (Azmacort, that was ended towards the end involving '09) are being used as first-collection asthma treatments. A bit of inhaling corticosteroids will be swallowed together with every single dosage, however itixl;azines much less compared to which found in by mouth adrenal cortical steroids. As a result, puffed adrenal cortical steroids minimize the probability of adverse reactions out of extended-phrase utilization of given.
Precisely how corticosteroid inhalers function
Consumed corticosteroids are sometimes the first style of relief medication given to master all about asthma. Simply by inhaling and exhaling the particular prescription medication, all these prescription drugs behave in your area to decrease redness within the air passage, thus keeping away from the medial side outcomes associated with lengthy-term utilization of oral adrenal cortical steroids.
Whom should not use these kind of medicinal drugs
Make use of
Corticosteroids for allergies are normally offered while instant inhalers comprising liquefied and also natural powder. Lots of breathed in merchandise currently have specific units, and you will often be completely advised concerning how to utilize inhalator prescribed by doctors for you. Consistency associated with management (the frequency of which you employ the inhaler) depends on the unique merchandise.
Medicine or perhaps meal connections
Because pill is local towards the respiratory tract, absolutely no pharmaceutical communications have been claimed.
Do not use for an severe asthma. Inhaled adrenal cortical steroids work so that you can slowly and gradually cut down throat infection and usually are of confined profit in the course of a serious episode with asthma attack. That's the reason these kind of prescription drugs will be upkeep or controlled medicine. It isn't intended for utilize to help remedy a serious assault. Inhaling adrenal cortical steroids may possibly minimize development in little ones, hence operate the cheapest measure achievable. Inhaled corticosteroids can also boost the chance of significant or terminal illness with folks already familiar with serious viral infections for instance varicella or even measles. Lengthy-term employ might cause cataracts and also glaucoma (higher force around the little brown eyes). These types of medications could raise the chance regarding pneumonia.
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Two Kindred Spirits: Neil Sedaka and Jim Van Slyke
“The Sedaka Show”
Jim Van Slyke
Directed and conceived by Brian Lane Green
Music direction and arrangements by Tim Di Pasqua
Laurie Beechman Theatre
At the West Bank Café,
407 West 42nd Street
March 5 at 7 p.m., 7 at 8 p.m., 14 at 4 p.m. and 15 at 7 p.m.
$15 cover, plus $15 food and/or beverage minimum, (212) 695-6909
Reviewed by Paulanne Simmons March 5, 2009
Jim Van Slyke
Jim Van Slyke, whose Sedaka show will be at the Laure Beechman Theater March 5, 7, 14 and 15, says that as long as he can remember he’s shared “striking similarities with Sedaka.” These similarities include the sound of their voices, the ability to play the piano and classical training. All of this is appealingly evident in Van Slyke’s show.
“The Sedaka Show” features many of the singer/composer’s hits: “Breaking Up Is Hard To Do,” “Laughter in the Rain” and a Doo Wop Medley that begins with “Oh Carol,” written for Carole Klein (a.k.a. Carole King) and ends with a tune made famous in a film starring Connie Francis, “Where the Boys Are.”
The show also includes “treasures that we dug up” and “unexpected collaborations” that reveal “a whole other side of Neil Sedaka.” Among these collaborations are “Bad Blood,” written with Phil Cody and interpreted by Elton John (“before he was sir”) and “Turning Back the Hands of Time,” with music by Giacomo Puccini and lyrics by Neil Sedaka.
One of the most delightful segments of the show is when Van Slyke sings songs from Sedaka’s children’s CD, songs with lyrics such as “where the toys are” and “waking up is hard to do.”
But for Van Slyke, Sedaka is at his best as a balladeer. And Van Slyke certainly does the composer justice with his warm and rich interpretations of songs like “The Hungry Years,” “Should’ve Never Let You Go” and “Solitaire.”
Except when Van Slyke takes over at the piano for “Solitaire,” he is accompanied by his musical director and arranger, Tim Di Pasqua, who occasionally adds his subtle, harmonic voice.
Directed and conceived by Brian Lane Green, “The Sedaka Show” is a captivating tribute to an artist who has been entertaining and thrilling audiences for five decades.
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Global Innovation Fund for Mission Aligned Development Organizations in the UK is now accepting applications for the year 2022.
The Global Innovation Fund, or GIF, is an investment instrument that prioritizes social impact. It finds and funds evidence-based innovations in collaboration with mission-aligned development agencies, charities, and other donors. These are innovations that have the potential to improve the lives of millions of the poorest people on the planet.
It complements conventional development aid by taking calculated risks that governmental agencies cannot take using a variety of financing instruments.
Worth of Award:
Pilot: Funding of up to USD 230,000 is available to test core assumptions around operational, social, and financial viability.
Test and transition: Funding of up to USD 2.3 million is available to support further growth and generate additional evidence on whether the innovation can achieve social impact and market viability, for commercial innovations.
Scale: Funding of up to USD 15 million is available to expand the reach of innovations with a view to reaching millions of people in the long term if successful.
Global Innovation Fund Eligibility
- Any form of organization is eligible to apply.
- In every country, this comprises social enterprises, for-profit businesses, non-profit organizations, government agencies, international organizations, and research institutes.
- Individual inventors, entrepreneurs, and researchers are encouraged to apply via an associated organization.
How to Apply for Global Innovation Fund
To start your application, simply click here.
Deadline: GIF accepts applications on a rolling basis – our window is always open with no deadlines or rounds of funding.
Visit the official website for more information.
Recommended for you

domain: finance


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Top 10 Timeshare Holiday DestinationsJuly 27, 2016
Get A Remarkable Experience From Classic Holidays ServicesAugust 10, 2016
Investing in timeshare is not a viable choice for those seeking to relax poolside at a resort. Many travellers and holiday makers are chasing holiday experiences that take them out of their comfort zone, stretching across the world to new and exciting locations.
A membership with Classic Holidays can provide just that. Classic Holidays has been making holidays happen for Australian and New Zealand families for over three decades, covering the globe with the best timeshare destinations for adventure-seeking travelers.
- Queens town, New Zealand: Whether it is bungee jumping or canyon swinging, white water rafting or jet boating, Queens town has got you covered when it comes to heart pumping action. With an array of Classic Holidays managed resorts located throughout the town, there is an option for everyone to enjoy a holiday in the adventure capital.
- Mount Buller, Victoria: Boarders and skiers can’t get enough of the slopes in this winter wonderland. Not only offering some of Australia’s best snow, the ski resort is easily accessible from the Classic Holiday managed resort in Mansfield.
- Canadian Rockies: Let Classic Holidays be responsible for your next adventurous getaway and jet off to the Canadian Rockies. This adventure hot spot boasts dog sledding, glacier hikes, snow mobile tours, caving and ice climbing to get the blood really pumping.It’s a fantastic location to visit all year round, with plenty of activities and scenery to make it one of the most sought after destinations in the world.
- Gold Coast, Australia: From thrilling theme parks, to skydiving over spectacular beaches, the Gold Coast is Australia’s fun capital. With theme parks, wildlife attractions, aerobatic adventures and natural wonders on the line-up, thrill seekers will be spoil for choice. The best part is, it’s all located just a stone’s throw from an extensive range of Classic Holiday resorts on the Gold Coast.
- Taupo, New Zealand: Home to the country’s best one day trek, the Tongariro Alpine Crossing leads hikers throughsteaming volcanic terrain, hot springs and craters, topped with views of a landscape like no other.There are a variety of timeshare resorts to choose from in the Taupo region, providing Classic Holidays members with access to a great range of accommodation.
- Antarctica: A membership with Classic Holidays will open the door to the most exciting destinations from across the globe. Cruising through this vast and isolated landscape will leave members in awe (and a thumping heart) as they pass through the maze of glacial scenery, wildlife and towering ice shelves.
- Machu Picchu, Peru: Turn your bucket list into a reality as you venture more than 2400 meters above sea level to this 15th century Incan citadel. This wonder of the world needs to be seen to be believed and offers a stretching view that will excite travelers from all walks of life.
- Tasmania, Australia: For those who love to adventure on foot, the apple isle is as good as it gets. There’s a trek to suit all fitness levels and you will uncover hidden treasures through some of the most pristine, untouched landscapes. There is no better place to relax and unwind after a long day on foot than with all the creature comforts of a Classic Holiday resort.
- Bargara, Queensland: An adventure for all the family can be found at the sleepy seaside town of Mon Repos, and all on the doorstep of Classic Holidays’ Don Pancho Beach Resort. Follow the Loggerhead Turtle on its journey to lay her eggs and the hatching of the young 6-8 weeks later as they venture back to the ocean, every year from November through to January.
- Kenya, Africa: It doesn’t get much more adventurous than a tented safariout on the open Kenyan plains. You will not only stay in the midst of the African wilderness, but experience the native wildlife in their natural habitat with your very own eyes.Kenya is a true adventurer’s paradise.

domain: travel


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We Help Companies Find New Sales Opportunities
TK Maxx is to open a 20,000 sq ft fashion store at Phoenix Park in Stoke-on-Trent by 2017, with the creation of 50 jobs.
TK Maxx is to set up a 635,000 sq ft regional distribution centre at Knottingley in Wakefield by January 2017.
TK Maxx is to set up a 30,000 sq ft fashion store at the St Andrews Square development in Edinburgh.
TK Maxx is reported to be seeking a suitable site in West Yorkshire for a 500,000 sq ft fashion distribution centre.
TK Maxx, the clothing and homewares retailer, is seeking a suitable location within the northern part of the M25 for a new headquarters of up to 350,000 sq ft.
TK Maxx is to create 80 jobs at a new fashion store due to open in Orpington in September.
TK Maxx is looking to recruit 100 new staff at its fashion distribution centre in Chesterton, Staffordshire.
TK Maxx is to create 45 jobs at a new 20,000 sq ft fashion store due to open at the Grand Junction Retail Park in Crewe this spring.
TK Maxx is to create 30 jobs at a new 16,000 sq ft store due to open at the Mell Square Centre in Solihull next spring.
TK Maxx is looking to recruit a further 100 staff at its fashion distribution centre in Chesterton, Staffordshire.
TK Maxx is to create 35 jobs at a new HomeSense homewares store due to open at the Forbury Retail Park in Reading in April.
TK Maxx is looking to recruit 100 staff at its fashion distribution centre in Chesterton.
TK Maxx is recruiting 200 seasonal staff to work at its fashion distribution warehouse in Chesterton, Staffordshire, from September.
TK Maxx is planning to expand its chain of 225 discount fashion stores to 275, while sister company HomeSense aims to expand its chain of eight homewares stores to more than 100.
TK Maxx is planning to open five HomeSense home furnishings stores of up to 15,000 sq ft in the South East next year.
TK Maxx is looking to increase the average size of its 200 fashion stores to 40,000 sq ft, by relocating to larger sites and expanding existing sites.
TK Maxx is looking to expand its chain of 154 discount fashion stores to about 300, and 30 sites will be refurbished this year.
TK Maxx, the clothing retailer, is said to be planning to transfer its warehousing and distribution operation to Walsall's Green Lane, with the creation of 850 jobs.
TK Maxx is planning to open 30 discount fashion stores in the UK this year.
TK Maxx is planning to expand its chain of 100 fashion stores with 35 new outlets a year, and believes there is potential for up to 250 in the UK.
TK Maxx has launched a recruitment drive for 800 staff to work at its new clothing distribution centre in North Staffordshire, which is due to open in January.
TK Maxx is seeking permission to build a distribution centre for its discount clothing business in Newcastle-under-Lyme, which would create 870 jobs.
TK Maxx is to set up a discount clothing store at the former C&A building in Worthing, with the creation of up to 70 jobs.
TK Maxx has announced plans to open a new store in Craigavon, with the creation of 50 jobs.
TK Maxx is opening a new fashion outlet in St Albans this month with the creation of 50 jobs.
TK Maxx is in negotiations to set up a discount clothes store in Hereford, with the creation of 50 jobs.
TK Maxx is to open a discount fashion store in York, with the creation of 50 jobs.
TK Maxx is planning to open a fashion store in the Captain Cook Square complex in Middlesbrough later this year, with the creation of 50 jobs.
TK Maxx is to set up a 27,000 sq ft fashion store at the £50m Kingsgate shopping scheme in Huddersfield, creating 30 jobs.

domain: economics


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The Coronavirus Business Interruption Loan Scheme (CBILS), managed by the British Business Bank, is one of the initiatives put in place to provide financial support to SMEs across the UK that are seeing a disruption to their cashflows as a direct result of COVID-19.
Other British Business Bank loan guarantee schemes designed to support businesses during the coronavirus outbreak are the Bounce Back Loan Scheme (BBLS), which enables businesses to access smaller loans more quickly, and the Coronavirus Large Business Interruption Loan Scheme for larger businesses with more significant funding requirements.
More recently, the new Future Fund which opened for applications on the 20th May 2020 will support innovative UK companies with good potential, that are essential in ensuring the country retains its world-leading position in science, innovation and technology.
NPIF Debt Fund Managers, Mercia and FW Capital, were recently accredited to the CBILS. Both can now provide CBILS loans using NPIF funding ranging between £100,000 and £750,000 to businesses that have been adversely affected by the impact of COVID-19.
They follow NPIF’s Microfinance Fund Managers, which have previously been accredited and can provide loans ranging from £25,000 to £100,00. GC Business Finance and MSIF provide support to businesses in the North West.
Click here for the full article.