Video Game Software Developer Unity is Partnering with HERE Technologies to Build 3D Maps for Vehicle Navigation Systems
【Summary】Mapping company HERE Technologies announced that it's partnering with San Francisco-based video game software developer Unity to add 3D graphics used for video game development to vehicle infotainment screens, including for maps and navigation. The 3D navigation represents the next-generation of in-vehicle human machine interfaces (HMI’s) for the auto industry.
Mapping company HERE Technologies announced that it's partnering with San Francisco-based video game software developer Unity to add 3D graphics used for video game development to vehicle infotainment screens, including for maps and navigation.
HERE is a leading provider of map content and location-based services to the global automotive industry. The company is owned by a consortium of German automakers, including Mercedes-Benz, BMW and Audi, as well as Tier-1 auto industry suppliers Bosch and Continental.
As part of the partnership, Unity and HERE Technologies will develop next-generation embedded automotive HMIs with state-of-the-art, real-time 3D (RT3D) graphics capabilities. The collaboration will also work on next-generation location technology for autonomous driving, simulations and city planning, the companies said.
The 3D navigation represents the next-generation of in-vehicle human machine interfaces (HMI's). The collaboration will combine automotive-grade map data with an advanced real-time 3D engine to offer a more dynamic automotive user-experience.
Using 3D maps for navigation can help drivers to better orient themselves, offering a detailed view of their surroundings and an easier way to visualize turn-by-turn driving directions while offering a more immersive experience for accessing in-vehicle infotainment options.
"Car buyers now care more about interactivity with their vehicle than horsepower or fuel-efficiency. Unity's work with HERE opens up the ability to meet consumer demand, providing a continuous user experience across all displays powered by Unity and our ecosystem," said Julien Faure, Vice President, Verticals at Unity. "By working with industry leaders like HERE, we feel that Unity has the potential to power dynamic infotainment, immersive augmentation, and geospatial and media experiences all integrated into a seamless user experience."
To showcase the capabilities of Unity's real-time 3D platform and HERE's mapping technology, the partners developed a proof-of-concept (PoC) application of an embedded in-vehicle-infotainment (IVI) system that demonstrates how the system might look to a driver navigating in the city of San Francisco.
The embedded system was built on Unity's platform and features HERE's 3D city data. The PoC showcases a futuristic, wide-screen navigation experience with a 3D map of San Francisco and demonstrates what developers can achieve with the addition of human machine interface (HMI) workflow design improvements.
HERE's 3D city data is highly detailed. In January the company announced that it created highly detailed 3D models of 80 major cities in the U.S., Europe and Asia. The models are called "HERE Premier 3D Cities" and are used to visualize cities in 3D. HERE said it will continue to add new cities to the list. The 3D city models can also integrate with HERE's standard navigation maps giving them an extra layer of detail.
As part of HERE's new partnership with Unity, the two companies are working to offer access to these 3D city models via a vehicle's navigation system, giving drivers a better visualization of their surroundings.
"The goal of our collaboration with Unity is to meet our customers' desire for an in-car navigation experience that's an engaging representation of reality," said Jorgen Behrens, Chief Product Officer, HERE Technologies. "Unity's robust 3D rendering engine makes HERE 3D city data, route guidance and navigation look impressive, providing a rich and immersive in-dash experience to the driver."
HERE Technologies built a 3D map of San Francisco and many other major city centers.
The HERE and Unity PoC application successfully runs on a Qualcomm Snapdragon central processing unit (CPU), which is designed for mobile devices. But In 2020, Unity announced collaborations with multiple hardware developers across the HMI ecosystem, including Continental AG subsidiary Elektrobit and NXP Semiconductors.
HERE Technologies is one of the world's biggest mapping companies. To date, the company has mapped 196 countries around the world. Each day, HERE said it collects more than 28 terabytes of celestial lidar data to keep its global maps up to date.
In addition to its 3D rendering for the video game industry, Unity operates a leading platform for creating and operating real-time 3D applications. The platform is used by architects, automotive designers, filmmakers. Now it's being used for the development dynamic automotive interfaces.
Originally hailing from New Jersey, Eric is a automotive & technology reporter covering the high-tech industry here in Silicon Valley. He has over 15 years of automotive experience and a bachelors degree in computer science. These skills, combined with technical writing and news reporting, allows him to fully understand and identify new and innovative technologies in the auto industry and beyond. He has worked at Uber on self-driving cars and as a technical writer, helping people to understand and work with technology.
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Espresso and Earl Grey
Society & Culture
Episode #9 Books, Books, Books!
This week we sit down and chat about books, books and more books! Grab your favourite cuppa and join us as we chat about reading and challenging ourselves to read.
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domain: literature


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Thank You Thank You Thank You
Giant Thanks go out to lindsay, she ran a contest for a superbowl recipe, in which her dh choose a winner. I won!!! I am so super excited to recieve the beautiful prize she is awarding. Shes sending me....
5 Heidi Grace patterned papers and a matching alpha (2 glittered papers, 1 embossed, paper, 2 double sided cardstock papers and a flocked cardstock alpha set).
I will be posting the finished pages here on my blog! hope I do the papers justice!! Thanks again lindsay!
Saturday, January 31, 2009
Posted by MoMo sprnany at 1:04 PM

domain: hobby


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Denver Mineral EngineersThe dimensions and weights of machines ... Sizes of conical mills are glven in diameter of the cylin- . APPROXIMATE CONICAL BALL MILL CAPACITIES.conical ball mill size and capacity,Size reduction and homogenization with ball mills - AB NinolabRETSCH ball mills are suitable for a wide range of applications. Depending on the model .. With their ability to process small . size reduction, mixing, homogenization, cell disruption. Feed material ... in anti-rotation device and conical.John Frank
. performance of a ball mill. The parameters studied in this work are particle size, number of balls, . Ball mills are cylindrical or conical shells rotating about a horizontal axis . number of balls not exceeding 50% of the mill capacity for proper.
mill products by means of particle size separation only, the advantages are numerous, . materials of construction, cone angles, vortex finder penetration and diameter, etc. .. SAG Mill (semi-autogenous) followed by Secondary Ball Mill.
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consumption, production capacity and cement quality are given. A case . size reduction and have high specific energy consumption kWh/t . . pre-grinder in cement grinding circuits operating with ball mills to reduce the specific energy . A cross section of a Loesche mill with a conical rotor-type classifier is shown in Figure .
mill, ball mill, cone mills or some other . significant narrowing of the particle size . improvements that further improve roller mill capabilities and efficiencies.
1927 First Loesche coal mill delivered for the Klingenberg power station in Berlin. . Unlimited spare parts delivery capability .. The feed material is reduced in size in a Loesche roller grinding mill .. of these coals in a laboratory ball mill (Hardgrove principle) is a .. able vanes and grit return cone, a rotor and a drive with.
to install and to operate and with a capacity range from. 50 up to 400 kg . a ball mill and a Thin-Film Evaporator (BLC), is designed .. Excellent particle-size distribution . A major advantage of the horizontal mill with conical grinding chamber.
includes a premixer and ball mill refiners for intermediate and/or fine . capacities, the Wiener CHOC lines or the F.B. Lehmann . Excellent particle size distribution .. The horizontal and conical grinding unit has a high flow rate design.
The grain size of the ball-milled solids are found to decrease with milling time down to a .. Nishin Giken (Tokyo, Japan) has developed the mill with the ability to control the temperature of ... a small chain forming a cone shape (Fig. 2.24a), the.
THE MIKRO® UMP ATTRITION MILL is a high speed cutting mill designed for the fine size reduction of plastics, polymers and fibrous . Capacities and fineness achieved is material .. Alpine SO – Ball Mill . Vrieco-Nauta Conical Screw Mixer.
capability enhancement) or alternatively reducing the part dimensions (Cost ... Ball milling is extensively used during the manufacture of ceramic powders .. Conical bottoms are used when mechanical handling of the powder should be.
requiring steel grinding media, and providing higher throughputs than cone crushers. .. throughout the orebody produces significant SAG capacity variation and thus .. declined, as larger diameter ball mills, accepting coarser feeds, became.
Feb 20, 2015 . led to reduction in particle size in case of the cone mill, for the same screen . In case of the cone mill, grated type screens exhibited higher milling capacity than ... P.T. Luckie, Process Engineering of Size Reduction: Ball Mill-.
DIAMETER. (D2) ... Ball end option for high performance contour milling in finishing operations. .. Having the ability to cut setup time and eliminate costly.
operational conditions, and allowed to evaluate the effect of ball size, rotation . mills. Finally, the final proposition of the model indicates its capability ... Figure IV-9 Dimensions for a conical end shaped SAG mill (Austin and Concha, 1994) 46.
May 6, 2004 . Key words: power draw, cement, dry grinding, ball mill . and later with minor revisions by Rowland, the mill size is determined (Rowland, . Power draw of conical section is calculated using Equation 4, and no-load power is.


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Five suspects were paraded on Wednesday 10 November after being arrested for alleged theft and destruction of property in the eastern port of Port Harcourt, the state capital of Rivers.
The suspects were paraded by Tami Peterside, the Police Commissioner, CP Eastern Port Command at the Nigerian Port Authority (NPA) premises in Port Harcourt.
The suspects are said to have operated in the port for several months before being followed and captured during an operation in the Bua area of the state.
It was revealed that the stolen items were worth N20 million.
However, the suspects denied the allegation and claimed they were on the waterways for entirely different reasons.
Recovered from the suspects were canoe, three gas cylinders, two wrenches, rusty iron fillings and grain.
The commissioner said the suspects would be prosecuted to serve as a warning to other criminals.
See more photos below:

domain: news


Our price estimate of $ 170 for Tesla Motors (NYSE:TSLA) is around 20% lower than the current market price. We expect 50% of Tesla’s value to come from its Gen III model and Model X, which are to be launched in September this year. While Model S, which constitutes more than 40% of our price estimate, is performing in line with our estimates, a large portion of the company’s valuation depends on the success of Gen III and Model X. Electric vehicles (EV) are a new market and Tesla has ambitious growth plans. It does have a competitive edge in terms of lower battery cost and a supercharger network, but its success will only be achieved through a significant number of milestones in the future.
EV Market Currently Driven By Government Incentives
In 2013, the EV market constituted about 2% of the total passenger vehicle market. We expect this figure to reach around 6% at the end of our forecast period.
Our forecast of the EV market is in line with Navigant research’s 2013-2020 Electric Vehicle Market Forecast, since this is a niche market with some uncertainties around its growth. The growth in this market is primarily driven by government incentives. Norway has the highest number of EV’s registered as a percent of total registered vehicles (33%)  This can be attributed to the absence of import tax on EV’s making them a viable alternative. In countries where these incentives are not provided, high costs of EVs make them less popular. Even in the U.S., EV cars are more popular in California where huge tax credits are offered. We expect these government incentives to increase in future with more focus on green vehicles, thus accelerating the growth in the EV market.
Tesla Has Competitive Advantage, But Is The Market Betting Too Much On The Future?
Tesla has strong innovative edge. Its battery costs are known to be much lower than most of its competitors and its battery performance is roughly 50% better than industry standards.((www.torquenews.com))
Given Tesla’s advantageous position, Gen III’s pricing could be somewhat more competitive and can improve Tesla’s market share.
Tesla’s strong supercharger network is another huge competitive edge. It boasts of 527 supercharger stations with 2983 superchargers. A 30 minute charge provides 170 miles of range compared to 10 miles in a 30A public charging station. Tesla claims that after at 30 minute charge, the car has enough range to reach the next charging station. . The charging cost is included in the price of the car providing the users a free lifetime supercharging. No other EV manufacturer has currently replicated Tesla’s supercharger model. Tesla’s target market of luxury buyers allows it to price the models higher to recover the costs of charging stations.
With increasing government incentives and a focus on low emission vehicles, we expect electric vehicles (EVs) to see tremendous growth. Tesla’s models are eagerly awaited and its technology provides it with a competitive edge. However, the stock price currently factors a huge growth in future, which is likely to primarily come from its yet to be launched models. Also, its distribution model of selling directly to customers is causing obstacles in several states in the U.S. Whether Tesla will be the success it is projected to be, is yet to be seen. Tesla’s valuation appears to be a huge bet on this future.Notes:


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The Heritage Handprints environmental group is composed of staff and students seeking to educate and act for a sustainable future at Heritage College. Students take on the environmental goals that they choose as a club, and staff and faculty continue to work on improving our footprint as a school community. The Heritage Handprints student club hosts regular student awareness initiatives such as clothing swap, smoothie day, harvest festival, Earth day fair, and waste audits. Heritage has a vibrant vegetable garden that is collectively maintained and enjoyed by staff and students.
On May 6, 2021 Heritage Handprints and volunteer faculty were able to safely come together and build 6 raised garden boxes, weed and fill boxes with soil and enjoy each other’s company(from a distance)! Great community event.
A group of volunteer students and staff, and a few classes began the garden project in May 2018. Typically seeds are planted indoors in March and continue planting in the garden directly in the spring. The food is harvested in the fall and is distributed amongst volunteers, classes and the Heritage community. Staff and students volunteer their time throughout the summer to water, weed, plant and harvest.

domain: agronomy


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Mrs. Kovacs is a nurse practitioner who joined Bergen Neurology Consultants in June of 2014. In 1987, she earned her nursing degree at Ewha University in Seoul, Korea. After moving to the United States in 1996, she graduated with a master’s degree in nursing, completing the adult acute care nurse practitioner program at the University of Medicine and Dentistry of NJ School of Nursing. Her clinical experience as a nurse practitioner(NP) positions include Pain Management at the Columbia Presbyterian Medical Center, and Spine Care at the Orthopedic surgery Department at NYU Langone Medical Center. She also has administrative experiences, working as a clinical nursing supervisor for a private duty nursing care company.
Mrs. Kovacs’ extensive experience in managing spine care patients has been a welcome addition to our practice.

domain: medical


The DoD’s FY24 Budget: Intel and Insights from the Latest Request
It’s March again, and that means the madness of the tournament, or rather the federal budget process, has begun. It’s the time of year when the federal government places its bets on priorities and initiatives that will require funding in the coming year(s). We’ll take a look at the Department of Defense’s (DoD’s) specific call-outs, what to watch for, and where you might place your own technologies across the complex landscape of agencies.
Readiness, R&D, and Dominance
The total $842 billion request breaks down to $185B for Army, $255B for the Navy, $259B dedicated to the Air Force, and approximately $141B Defense-wide.
This latest budget request notes an overall stance of global competition among adversaries, with particular focus on the People’s Republic of China (PRC) and Russia as it relates to the US’ need to maintain both its readiness and bolster dominance across research and development (R&D) and deterrence initiatives. Readiness, or strategically building and maintaining warfighting forces and capabilities, is a key component woven across number of elements. Requests for funding targeted to this objective across each DoD agency include:
- Army readiness - $28.8 billion
- Navy readiness - $52.8 billion
- Marine Corps readiness - $4.4 billion
- Air Force readiness - $39.9 billion
- Space Force readiness - $3.3 billion
- U.S. Special Operations Command readiness - $9.7 billion
- Joint Capabilities - $7.1 billion
Vendors looking to capture dollars associated with readiness objectives will find information technology needs attached for example to the Army’s ground and aviation training strategies to train and prepare soldiers, leaders, and units to support current and future operations. The Air Force also calls out the request for IT upgrades, specifically to modernize its network infrastructure and strengthen their cybersecurity posture, enabling worldwide training and exercises to field an agile combat force.
Research and Development will also see an uptick in importance in FY24, as it’s tagged to receive $145B. There’s further frank and elaborate discussion of the need to maintain dominance, while jointly activating and empowering the men and women in military with an ample pay raise. In addition to the more sweeping objectives, the DoD is also keenly aware of its investments, and enhancing and improving its procurement processes with an estimated $170B set aside for acquisitions alone. This is the largest chunk of change for procurement in history.
While the budget request is heavy on building and maintaining tactical equipment and upgrades, it certainly doesn’t fall short in noting IT investments as they relate to securing the Defense Industrial Base (DIB). As a vendor in technology, you will find plenty of opportunities in the coming fiscal year.
Notably, the artificial intelligence (AI) space is set to receive $1.8 billion, encompassing a number of technology products and services designed to aid in more efficient problem-solving and decision-making across agencies.
Anyone following the progress of the Joint All-Domain Command and Control (JADC2) effort will be pleased to see $1.4 billion “to transform warfighting capability by delivering information advantage at the speed of relevance across all domains and partners.” JADC2 is the joint effort to provide interoperable technologies, sensors, IT and communications equipment within and between DoD agencies.
Blending the need for function with IT security, $3.7 billion is also marked for installation resilience and adaptation, including cyber-secure microgrids with backup power and battery storage, and electrical transmission and distribution improvements. As with many of the equipment and infrastructure investments across the request, most include a need for information technology and cyber-resilient security.
The DoD has continued to bolster its cyber security needs, as directives related to building its zero trust architecture as well as the more recently released National Cybersecurity Strategy in March of 2023 have published guidance and deadlines for securing IT networks and infrastructure. The budget request builds on these objectives, adding in another $13.5 billion for cyberspace activities as well, representing a notable 20% increase from FY23 levels.
Targeting the Right Space in FY24
It’s clear the Department of Defense is focused primarily on enhancing the existing forces with secure, resilient and dominant initiatives. Opportunity abounds for those in the IT space, as it is keenly baked-in across nearly every investment, from weapons systems to the more tactical AI capability needs. Another fiscal year of requested funding has yet again surpassed the previous. There’s no shortage of dollars available; it’s simply a matter of approaching agencies with the technologies capable of effectively addressing these requested FY24 budget objectives.
To get more TD SYNNEX Public Sector Market Insight content, please visit our Market Intelligence microsite.
About the Author:
Susanna Patten is a senior analyst on the TD SYNNEX Public Sector Market Insights team covering tech domain centric trends across the Public Sector.


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Almond Butter & Cacao Recovery Smoothie RecipeNovember 6th, 2018
Reward your muscles after a tough workout with a delicious smoothie to help you refuel and recover. The short ingredient list (think dates, cacao, spirulina, and powdered almond butter) means a stocked pantry is all you need to make this drink on repeat.
Almond Butter & Cacao Recovery Smoothie
Yield: 1 serving
Active Time: 5 minutes
Place all ingredients a blender and purée until smooth. Pour into a glass and serve.
Recipe credit: Angela Gaines

domain: health


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Hello crafty friends! Today I have a card created for reminder post at Magnolia challenges. The first one is Magnolia Forever with the theme
And Marvelous Magnolia challenge with the theme
I have created a Halloween themed step card. I love the design of step card that it allows to add layers on each step so you can create dimension and perspective view on your card.
I decorated the card with die cuts and sentiment. The farthest is from Cottage Cutz Halloween Night Scene. The Little Ghost die cuts are from Yvonne Creations. Tree and pumpkin die cuts are from Doohickey Old Oak, and Volume 6. The sentiment is the stamp from LDRS.
This cute Tilda is from Magnolia “Hear No Evil Tilda” stamp from Pink & Blue Ribbon 2014 collection. I colored the image with distress ink. It looks like she is scared of something. I think she is perfect for Halloween card.
To add some fun on the card, I applied glow in the dark embossing powder on some die cuts. When the light is turned off, these die cuts will glow green and create haunting feeling.
I would like to enter this card to these challenges.
- All About Magnolia Challenge #27 – All About Fall/ Halloween
- Cards Und More Shop Challenge #17 - Anything Goes with Pumpkin
- Creative Inspirations Challenge #282 - Autumn/ Halloween
- Deep Ocean Challenge #166 – Halloween
- Magnolia-licious Challenge #14 – Anything Goes w/ the optionof Halloween
- Midweek Magnolias Challenge #175 – Anything Goes
- Noor Design October Challenge – Fall Colors
- Paradise of Magnolia Challenge #58 - Fall/ Halloween
- The Ribbon Girl October Image Challenge
- Scrapy Land Challenge #76 – Anything Goes
Hope you like my card today. Thank you for stopping by and have a nice day.


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Does a modern woman need to arm herself — sartorially speaking, that is — to survive unknowns, economic and otherwise? According to Rodriguez, absolutely.
Camouflage prints and militaristic shaping — sharp cap sleeves, tight high collars — told a warrior story, mostly one of winning moments. Rodriguez’s muse has always been body-conscious, and he constructs curve-hugging silhouettes that at their best eschew overt sizzle for streamlined sensuality, a theme that started out superbly here: chic skinny gabardine riding pants and taupe twill jackets, cut narrow with crisscross paneling. The daywear was followed with silk crepe dresses in white and acid green and lean knit sheaths, some with attached fluttering scarves and hooded bodysuits, calling to mind a lean and groovy Amelia Earhart. The jackets, too, in jacquard, mohair and wool tweed, offered up excellent cool-weather coverage, which by contrast made those Lite-Brite bandage dresses seem derivative and loud.
And while there may be only so much utility in this statement print, the black-and-white camouflage motif — worked into lace dresses and chine coats and pants and paired with Albertus Swanepoel’s terrifically spooky bucket hats — lent a clever take-no-prisoners vibe.

domain: design


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Weight-loss blog.hu may likewise imply having additional energy throughout the day. By eating far healthier and also much more healthy meals you will definitely keep your body operating better and aid you deal with illness and experience far better. When you are actually consuming a balanced diet regimen that features a lot of fruits, vegetables, whole surfaces, and slim healthy proteins, your body system will definitely have the fuel it needs to have to keep strong and functionality well.
You should be actually aware that when you lose body weight you will definitely observe numerous various other improvements in your appeal. You will definitely possess a much more determined and also slimmer look, and you are going to observe a decrease in tiredness and also tension levels.
As you reduce weight, you will certainly likewise notice that you possess a better harmony between your bodily and also mental being. You will certainly possess boosted strength as well as power, you will certainly experience better general, and also you will possess extra self-esteem. If you have been struggling along with a low self-image or even anxiety for some time, this is really necessary.
If you intend to learn how to reduce weight, ensure you look for specialist assistance and do your own research prior to you begin a plan of action. There are actually many different choices accessible, yet you require to select the one that best accommodates your specific targets. for weight management.
Weight management is a method that calls for effort and determination. There are going to be times when it does not work out properly, yet it won’t take lengthy just before you find end results. Bear in mind that a good mindset is actually key to the entire process as well as to your general health and wellness.
Inexplicable body weight increase of more than 5 per-cent or even much more than 10 pounds can also be actually a sign of a major health care health condition in several much older grownups. Therefore what are the triggers for sudden unexplained weight gain?
In such situations, extreme body weight gain, or even excess body system weight can easily show the necessity for immediate clinical interest. Numerous other illness and also conditions can lead in quick unexpected weight gain such as cancer cells, liver, cancer as well as diabetes mellitus health condition.
Medical professionals usually deal with unexpected weight gain as the end result of sudden clinical concern or illness. Thus, the root cause of quick weight increase might certainly not be actually as serious as in severe conditions like heart problem, kidney failing, or even cancer, yet it is consistently most ideal to seek prompt medical attention if you discover the signs and symptoms.
In some cases, abrupt weight increase may be as a result of psychological concerns like anxiety and stress and anxiety. In such scenarios, the person is provided medicine to soothe the symptoms as well as lower the degree of stress and anxiety in his lifestyle.
A major health ailment like cancer cells may additionally lead to abrupt body weight gain and weight loss. Some researches have revealed that body weight increase after cancer procedure is significantly lesser matched up to body weight gain after the very same procedures in healthy people.
A few other reasons for quick weight increase include hormonal inequalities, mental disease, and certain medicines. In women, quick body weight increase has actually been attributed to high amounts of oestrogen. Females might experience uncommonly exhausted during the course of menopause, so they may gain weight given that their body’s metabolic process reduces.
In severe scenarios of psychological ailment like schizophrenia, quick weight increase might be triggered by stress. In this situation, a physician will definitely be spoken to for proper treatment.
Weight-loss may aid a whole lot in reducing the signs and symptoms of anxiety and also depression. If the reason of sudden weight gain is psychological, counseling is regularly wise.
Some individuals feel that sudden weight increase is actually triggered by overeating or even the consumption of excessive quantities of caffeine. However, this is actually certainly not the case considering that much of the meals that people think of as being “bad” actually contain body fat. People that are already struggling with weight concerns may lean to eat way too much on those foods they already eat.
A lot of the quick weight gain may be credited to harmful consuming behaviors or inadequate dietary behaviors. If a person desires to drop weight quick, at that point he or she should always stay clear of consuming fast food, junk food as well as processed meals to acquire the desired results.
Fat loss should regularly start along with the best meals choices. One must always make sure that the food items that is being consumed is actually clean as well as healthy. It is essential to learn to consume the appropriate amount of calories. of food daily for the physical body to work effectively.
In fact, when one goes on a diet, one need to be sure to maintain a record of the meals that were actually eaten. Because the body adjusts to the change progressively, this is essential. As a basic regulation, individuals who want to reduce weight must consume regarding 500 fats less every day than they will ordinarily eat in a full week.
One of the primary causes of quick body weight gain can easily also be due to a bad way of life. Individuals who carry out certainly not exercise properly ought to consider working out. This is actually particularly accurate for people that have bad blood sugar level amounts.


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[Versailles, Maison Close, Petit Place, Mars 1921 (Brothel, Versailles, Petit Place, March 1921)]
Eugène Atget (French, 1857 - 1927)
Paris, France (Place Created)
Gelatin silver chloride printing-out paper print
21.8 × 16.4 cm (8 9/16 × 6 7/16 in.)
In 1921 the painter André Dignimont (1891-1965) commissioned Eugène Atget to make a series of photographs of prostitutes for a possible publication. About a dozen pictures resulted, taken between March and May. Some, like this one, were created in the town of Versailles, where this woman lingers in the doorway of a brothel, indicated by the size of the street number over the door. Prohibited from identifying their bordellos with signs, proprietors resorted to posting larger than ordinary numerals—some more conspicuous than this example—so that customers could recognize the true nature of the establishments.
Despite her self-protectively crossed arms, the prostitute who poses in front of this scarred facade does not seem averse to being photographed. A friendly, if not particularly alluring, smile is fixed on her heavily made-up face, and clearly she wears her working costume. Her skirt is extremely short for the time, like those of some of the other prostitutes that Atget photographed. Its abbreviated length is intended to attract customers by displaying her legs. Similarly, her high-laced boots can be assumed to have a sexual connotation, which is perhaps somewhat at odds with her bright white socks. The fox fur that hangs limply from her shoulders presumably is meant to add a touch of class to her appearance. It would be interesting to know how Atget explained his objective to this woman and if he paid to photograph her. His even-handed treatment of her is parallel to his images of tradespeople (see 94.XM.108.4, 90.XM.127.4, and 90.XM.64.26). Of all of Atget's pictures, only this series and three nudes, probably made in a brothel in 1925, deal with sexuality.
Originally published in Eugène Atget, In Focus: Photographs from the J. Paul Getty Museum by Gordon Baldwin (Los Angeles: J. Paul Getty Museum, 2000), 66. ©2000, J. Paul Getty Trust.
Daniel Wolf, Inc. New York, NY, USA
Persistent Themes: Notable Photography Acquisitions, 1985-1990 (June 5 to September 2, 1990)
- The J. Paul Getty Museum (Malibu), June 5 to September 2, 1990
Atget's Magical Analysis: Photographs 1915-1927 (October 29, 1991 to January 5, 1992)
- The J. Paul Getty Museum (Malibu), October 29, 1991 to January 5, 1992
Arrows of Time: Photographs from the J. Paul Getty Museum (January 24 to April 2, 1995)
- Armand Hammer Museum of Art and Cultural Center at UCLA (Los Angeles), January 24 to April 2, 1995
Lifson, Ben. Eugéne Atget (New York: Hacker Art Books, 1980), pl. 51.
Szarkowski, John and Maria Morris Hambourg. The Work of Atget. 4 vols. (New York: Museum of Modern Art; Boston: Distributed by New York Graphic Society, 1981-1985) vol. 4, pl. 67.
Naef, Weston. Atget's Magical Analysis: Photographs 1915-1927, exh. brochure (Los Angeles: J. Paul Getty Museum, 1991), fig. 1.
Baldwin, Gordon. In Focus: Eugène Atget: Photographs from the J. Paul Getty Museum (Los Angeles: J. Paul Getty Museum, 2000), pl. 30.

domain: artistic


Shenzhen will begin to build the world's first 5G-led intelligent networked transportation test base
With the continuous development of intelligent networked vehicles, there are more and more intelligent networked transportation test projects in China. According to a report on Shenzhen’s official Weibo account, recently, the second phase of the main area civil works in the planning of the Shenzhen Intelligent Networked Transportation Test Platform in Pingshan District, Shenzhen was officially launched.
According to reports, the project is expected to be completed and put into use in 2023. At the same time, the project will build the world's first three-dimensional future urban transportation system and a 5G-led intelligent networked transportation test base. The "Shenzhen Action Plan for Cultivating and Developing Intelligent Connected Automobile Industry Clusters (2022-2025)" released this year clearly states that the intelligent networked automobile industry will be laid out in Pingshan District, Nanshan District, and Shenzhen-Shantou Special Cooperation Zone, among which Pingshan District It has both R&D design and manufacturing functions.
After completion, the demonstration platform will realize the country's first 5G scenario-based and virtual city-based cloud simulation, and will be the first in the world to implement advanced prediction technology for real-time prediction of driving trajectories, complete the V2X (vehicle wireless communication) interconnection application demonstration activity, and become an intelligent network. The key supporting infrastructure for the development of the automotive industry.
On August 23, the Shenzhen Municipal Bureau of Transportation announced on its official Weibo that at present, Shenzhen has opened a total of about 201.37 kilometers of test roads for intelligent networked vehicles, and 187 test roads have been opened. Among them, the first batch of open roads is 124 kilometers, with 105 open roads, and the second batch of 20.69 kilometers, with 29 open roads.


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Arizona law designates the following dangerous operating practices as illegal.
Overloading is loading the vessel beyond its safe carrying capacity or the recommended capacity shown on the capacity plate. Take into consideration the weather and other operating conditions when determining if the vessel is overloaded.
Riding on the Bow or Gunwales is allowing passengers to ride where there may be a chance of falling overboard while underway at greater than “no wake speed” (or “wakeless speed”) on a powerboat. Specifically, this means allowing passengers to ride on the covered bow, transom, swim step, or gunwales unless these are designed for carrying passengers at all speeds.

domain: law


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Rising up from the Long Island Music Scene, A Place To Hide is comprised of Nick Rigali, Nick Valero, and Ryan Mastrelli.
The three met in 2014 at a local music shop, where they fulfilled their craving to play in a band, and they’re now known for bringing the energy to the stage; from syncopated rhythms, exciting choruses, and an authentic live feel.
The music of A Place To Hide combines all the problematic issues, hardships, and journeys the members went through to find their place to hide; where you know you’re not alone in your struggles. Through an amplified essence of passion, the Post Hardcore soundscapes of A Place To Hide are electrifyingly illuminated in “So Wrong.” Being a trio, there’s a certain connection that allows the musicality of each instrument to shine in its own environment as the band is seamlessly glued together in syncopation.
Delivering a surge of hard-hitting relief in an impactful universe of belonging, the words that are passionately performed collide with the tightly knit drum patterns, resonated bassline, and propelling guitar riffs that drive this composition forward. Carrying dark connotations in the melodic spirits lurking, everything about “So Wrong,” is intensified with the edge factor being elevated to a newfound dimension. Capturing the stand-out moment glistening in the spotlight, we digest the entirety of unique self-reflection that dangles from the songwriting techniques as it is backed with empowerment from the bolstering percussion hits.
Transitioning through time signatures as we reach the final moments of “So Wrong,” A Place To Hide gently eases us into the culmination of the arrangement. Tiptoeing in realms that spark a sense of intriguing creativity, A Place To Hide continues to deliver the cutting-edge atmospheres that we gratifyingly thrive in.
We love the rollercoaster of intensity that you tour us through in “So Wrong.” Could you please share the inspiration behind this song?
The inspiration behind "So Wrong" was to create a high-energy song that would be fun for us to play live and for fans at shows to move to We set out to write the best APTH song that we have written so far.
What does this song mean to you as a band? Does it hold the same meaning to everyone across the board or do you find its meaning can shift in an authentic way?
For the band, "So Wrong" has a shared meaning. We see it as the acclimation of our struggles, going away to college, and being in different places physically and mentally while maintaining a commitment to the band. For others that are listening to the song, we feel the meaning can morph based on the situation that person is in.
We would love for you to share a glimpse of the creative process that brought this track to life. What did that process look like? Was there anyone to help you achieve the desired sound we hear and love?
"So Wrong" started with the intro guitar/bass riff written by Nick Valero. He then brought it to the guitarist, Nick Rigiali and they collaborated to bring it to the next level. The two kept developing the song, recording it into Rigali’s computer in his bedroom eventually turning it into a demo with computer drums and rough vocals. They brought it to Ryan and he finalized the drum part, giving it high energy with a touch of pop-punk influence. Once the band rehearsed the song, the group reached out to their producer Ryan Schumer, who helped them shape the song in the studio harnessing the staple APTH sound. The band recorded at VuDu studios in January 2021 and "So Wrong" has a scheduled release date of April 30th, 2021.
How do you find “So Wrong,” compares to other songs heard in your music catalog?
"So Wrong" is the next step in A Place To Hide's sound. We bring our signature sound from our past, but it is an indicator of how our sound is to evolve in the future. We’ve really found our voice with this new track but it is always changing as our musical tastes and influences evolve. We don’t know where we’ll go but we know we are going to keep improving.


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domain: food


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CDC director says 75% of COVID-19 deaths ‘had four or more comorbidities’
(Worthy News) – Dr. Rochelle Walensky, the director of the Centers for Disease Control and Prevention, said 75% of people who died of COVID-19 had at least four comorbidities, sparking an outpouring of commentary from people surprised by her statement and others saying, “I told you so.”
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JAMES NANCE: THE RIGHT MAN ARRIVES TOO LATE
James Nance would become Packard’s president on May 1, 1952.
By then, the image of Cadillac as the prestige American automobile was cemented in public perception. On November 5, 1953, a new Broadway production opened at the Belasco Theatre in New York City: “The Solid Gold Cadillac.” It would run for 526 consecutive performances, closing on February 12, 1955, and become a hit movie the following year. The title came from the gift given the hero and heroine at the end of the play – the most prestigious gift conceivable: a solid gold Cadillac. In the public mind, though, the ‘solid gold’ was almost superfluous. Everyone knew Cadillac was the best.
The new model Packard had introduced for 1951 did not have a V-8 engine. It did not have an automatic transmission capable of shifting gears. The bodies were produced by Briggs, not by Packard. It did not reposition Packard as a luxury, rather than mid-priced, brand.
It was, however, with that new model that James Nance was hired to rescue Packard.
Nance came aboard with some of the work already done. The president who replaced Christopher at Packard, Hugh Ferry, had taken several steps in the ‘better late than never’ category, decisions that should have been made by Macauley and Christopher. In January of 1952, he’d secured approval for development of a Packard V-8 engine and construction of a new plant to manufacture it (though the costs were not actually budgeted until after Nance became president). He introduced Packard’s own two door hardtop, the Mayfair, in February of that year. It was Ferry who bought the rights to the torsion bar suspension system that would be introduced while Nance was company president.
Yet the legacy of Alvan Macauley and the perpetually capital starved Packard Motor Company he left to his successors influenced even Ferry, though Ferry fully understood the necessity of Packard catching up to its competition to survive.
Ferry had become Packard’s president because someone had to do it and Christopher’s forced departure had occurred suddenly, leaving no time to plan for succession. Ferry, from the outset, regarded finding his replacement as his top priority. In the meantime, however, he needed to keep the company alive. His background was in finance – he’d started as a cost accountant, risen through the ranks to become corporate Secretary and Treasurer, then Vice-President. He knew as well as anyone the financial condition of the company, the impact of its dismal sales, and the capital expenditures required in the next few years to manufacture new models with modern features.
In short, he knew he needed money.
Ferry took advantage of the government’s need for manufacturing capacity to fight the Korean War and contracted with the United States government to produce diesel engines and the General Electric J-47 turbojet engine. He expected profits from the government contracts would underwrite the costs of modernizing Packard’s automobile line. The contracts would potentially generate income (i.e., gross sales, not net profit) of $200,000,000 a year. A steady flow of profits from those contracts would buy Packard time, financing the ongoing costs of new models and new features and giving Packard the lifeline it needed to keep going until the sales of those new models could sustain it.
Unfortunately, these contracts required that Packard make the investment necessary to produce the products contracted, including building a new manufacturing plant. This meant Packard was spending its capital – $17,000,000 of it in total – now and up front. Ferry viewed that as a down payment on a much larger stream of future revenue. But it was also meant depriving the automobile business of that same money – to the detriment of the product line the defense business was intended to succor.
In this decision, we see the ghost of Alvan Macauley still haunting Packard.
As he likely saw it, Ferry had two choices. He could commit the money for capital expenditures needed to fulfill the contracts. Or he could put that money into the development of new models, powertrains, and features for Packards that would be introduced in the coming years. The later choice gambled that the company could keep going until it could catch up. The former promised a revenue stream that would buy the time needed to catch up.
He chose the former.
But there was a third choice.
To raise additional capital to finance the investment needed for the defense contracts, Ferry could have borrowed the money or he could have issued new stock in the company.
He should have done one or the other, or even both.
Borrowing to finance the defense contract investment should have been easy. Packard was debt-free, reported profits in its annual reports, and the contracts themselves promised a guaranteed revenue stream that would easily repay the principal and interest of the loan. Issuing stock might have presented more complicated issues, as it would have been viewed as diluting the value of currently issued shares. But there was a clear rationale for a new issue of stock to finance entry into a new business that promised to increase overall corporate profits to the benefit of all shareholders.
By the early 1950’s, the automobile industry – led by General Motors – was evolving into a three-year model replacement cycle. A new model would be introduced, slightly face lifted the second year, dramatically face-lifted in the third, and replaced with a completely new model the next year – and the cycle would start again. That completely new model might carry over the same engines and transmissions, but new tooling would be required for the rest of the car.
From a 2.5 percent share of the United States automobile market in 1948, Packard’s share fell to 2.1 percent in 1949, and dropped again to 1.7 percent in 1950. In 1951, Packard had a 1.43 percent share. The effect of this low volume impacted every aspect of its automobile business. Although it advertised much less, Packard’s advertising cost per vehicle sold was twice that of Cadillac. Having forsaken its own production facilities to subcontract body production to Briggs, its component costs for bodies were higher than its those of its competitors and it had less control over those costs. Its deal with Briggs still required it to pay for tooling, and that meant the cost of tooling per vehicle was higher, as well.
This was the point at which Packard needed to invest in its automotive operations. To do that, it needed all the capital it could muster. Ferry was probably correct in his belief that Packard needed the profits from the defense contracts to keep the company afloat while the company developed and introduced new models. But that process also required that Packard make a large investment now in the next generation of Packards that would be introduced. It needed to use the capital it had to develop new automobiles, not divert it to a government contract.
There is no indication that either borrowing or issuing stock were seriously entertained as options for funding the defense contract investment. Apart from War years, when Packard had incurred debt offset by receivables, Packard management financed development and production internally and avoided long-term debt. That culture, dating from Macauley’s years of control, appears to have limited Ferry’s perception of his options. He understood that he needed to consider the long-term. He appears not to have understood that there is an opportunity cost to financing internally and that it is sometimes better to rent other people’s money rather than risk your own.
Despite its competitive short-comings, the new Packard body design for the 1951 model year turned a loss in the first three quarters of the year into a $5,200,000 profit for the full year.
But it was a middle-priced car, not a luxury market automobile. The lowest priced model, the 200, accounted for 71,362 of the 100,713 automobiles produced. The top line Patrician 400 was almost indistinguishable in outward appearance from the 200 – and available only as a sedan. The car continued a straight eight engine and the Ultramatic transmission.
It was carried over with only minor trim changes as the 1952 and 1953 models.
In remarks delivered to a group of Packard executives shortly after his election as President, Nance made it clear that he understood where Packard stood and what it ought to do. He criticized outsourcing production, explaining it created a “vicious circle” of increased costs. He challenged a system in which design of parts did not consider cost – advocating “planning for costs.” He insisted that if parts were to be outsourced, the manufacturers of those parts needed to deliver the most advanced technology available.
He then turned to the public perception of the brand and what to do about it:
“To the man in his forties or over, Packard stands for quality. He still thinks of it as a quality car, an impression he got as a young man. But to the younger person of say thirty-five, Packard doesn’t stand for anything. Now, you ask the man on the street today, whether he is twenty-five, fifty, or seventy-five, what Buick stands for and you’ll get a pretty universal answer: it’s a good solid automobile in the upper middle price class. You ask what Cadillac stands for and every kid on the curbstone can tell you, ‘That’s the best, mister.’ Now we’re supposed to be in three of the five price classes, competing in the top bracket, for example, against Cadillac, the big Buick, and the two Chryslers, and we’re getting a miserable 3 ½ percent of that business. Packard! Three and a half percent.
“Now we must make a decision, gentlemen. And whatever that decision is, I’ll be damned if I’m going to be in a horse race and get left at the quarter pole. Let’s get in or get out. If we are going to make a quality car, then let’s get in the race, and if we’re going to abandon the field, then by God let’s do it with honor. Not by default.”
Nance’s remarks were somewhat self-contradictory. He acknowledged that Cadillac, not Packard, was perceived as “the best,” but professed to consider Packard still a competitor of Cadillac. He posited that Packard should not abandon the luxury field by default when his predecessors had already done precisely that. He was now faced with attempting a return to the luxury market with an automobile plainly produced for the mid-priced market.
The problem Nance faced was one that could only be solved with time. At best, the existing model dating from 1951 could be dressed up and efforts made to distinguish the Patrician version from the plebian one. But these could not fundamentally alter the product itself and, consequently, could only lay the groundwork for more dramatic differentiation in new models to come. Ferry had understood this. It was the reason he had invested in defense contracts that promised to bring Packard a constant cash flow to buy that time.
Nance immediately started the process of moving back into the luxury automobile market. He attempted to separate the premium models from those in the mid-price range, renaming the latter Clippers. To add glamour to the new premium line, he added the Caribbean convertible – at over $5,000 it was squarely in the Cadillac price range (though more directly competitive with the Buick Skylark). In an effort to match Cadillac’s most premium models, Packard introduced the Packard Derham – a custom formal sedan with an interior divider window separating driver and passenger compartments and padded leather top covering that was based on the Patrician – and contracted with Henny for production of long wheelbase sedans and limousines. (Derham was an established custom body builder dating to the classic car era of the thirties; Henney was the company that manufactured ambulances and hearses on Packard commercial chassis.) These were baby steps, but essential to reestablishing the name “Packard” as synonymous with “luxury car.”
Yet, to assuage dealer complaints, the distinction Nance was attempting to create was blurred. The company’s own consumer surveys had determined that the Packard name was important to retaining owners as repeat buyers. Understandably, dealers did not want the lower-priced line divorced from that name. Hence, the Clipper became the “Packard Clipper” in advertising.
The concession was probably considered of little consequence at the time. The 1953 Clipper and Packard shared the same body – they were obviously the same basic car.
In 1953, Cadillac sold 109,651 automobiles. Packard sold 90,252. Though that superficially suggests Packard was competitive, the raw numbers don’t tell the full story. Cadillacs were sold only in the luxury car market. Most of Packard’s sales were in the mid-price market. In that market, Packard competed against Buick with 468,755 automobiles sold in 1953 and Oldsmobile with sales of 344,462 in 1953. It also competed with Chrysler, DeSoto, and Hudson. Even Lincoln, with sales of 40,473 automobiles in 1953, outsold Packard in the luxury market.
Seen in this light, it is obvious that Packard was uncompetitive in both luxury and mid-priced ranges. That is why Nance wanted to move the Packard brand fully into the luxury market and separate its identity from that of the Clipper. The luxury market was the smaller pond, where prices and profits were higher and where, though the competition with Cadillac would be challenging, at least there were fewer brands competing.
Separating the Packard and Clipper model lines was simply the first step in a plan, initiated under Ferry but revised and accelerated by Nance, to introduce fully new models with V-8 engines. As adopted by Packard’s executive committee in November of 1952, the 1954 Packard line would receive an entirely new body. The 1954 Clipper would be a facelift. In 1955, the V-8 would be introduced, the Packard would receive a facelift, and the Clipper would be all new. As the plan’s implementation progressed, the 1954 target became 1955. It was all part of a plan Nance envisioned that spread over five years and aimed at fully reestablishing Packard in the luxury automobile field by 1958.
Cadillac, however, had established itself. If it were not the “Standard of the World” as it claimed, certainly it was the standard against which any luxury automobile would be compared. It had the best styling, the best technology, and – as Nance’s “kid at the curbstone already knew – was considered “the best.”
And Cadillac would not be standing still while Packard tried to catch up.
Moreover, even Nance’s plan did not truly change the company’s dependence on selling middle-priced models. Though it envisioned Packard as again a true competitor in the luxury market against Cadillac, the company itself would still be competing against Buick, Oldsmobile, Chrysler, and others in the middle price market. Packard’s dealers were too dependent on selling in that market for the company to become exclusively a luxury brand manufacturer.
The rescue plan ended almost before it began.
In early 1953, the Defense Department reduced the jet engine contract from $392 million to $218 million, which equated to a $42 million decrease in 1953 contract revenue.
Then Briggs fell short of production targets, by 5,000 vehicles in the first quarter of 1953.
Packard was still making an operating profit, but the supply of unsold cars was building to 55 days, as the sales of the more expensive models were declining. This compared to an industry average supply of 31 days. The backlog of unsold models meant cutting production numbers below break-even to avoid a glut. The company was still reported a profit for the year, but the drop in sales would continue into 1954, as the models introduced in 1952 entered their third year of production. Plans to begin production of the 1954 models in October were modified to begin production in January of 1954.
Then the government further cut back on the jet engine contract, reducing the rate of production but extending the duration of the production run. That again reduced annual contract income.
On January 17, 1952, Walter O. Brigg died. To pay federal estate taxes, the heirs sold the company to Chrysler Corporation, for whom Briggs had also been manufacturing bodies. That would ultimately force Packard to again produce bodies itself.
It was then, on March 1, 1954, that company treasurer Walter Grant wrote Nance that “the company is rapidly approaching bankruptcy.” “Substantial expenditures” were needed to complete the new engine plant (for the V-8) and lease the Connor Avenue body assembly plant from Briggs. (The lease was $758,568 per year for five years. Cost of setting up production was projected at $3,000,000.) At the existing rate of expense, working capital would be exhausted by June 30, 1955. An $11,000,000 pre-tax loss was expected for the year, and current inventories of unsold models at dealers and Packard inventory exceeded 90 days’ supply.
It was these circumstances that led to the decision to hire investment banking firm Lehman Brothers to evaluate combining with Studebaker. Their report unequivocally recommended doing so. The financial press, as well, encouraged the companies to join. In its August 30, 1954, issue, Time magazine summed up the prevailing view:
“For its part, Packard will get the advantages of the slick styling that has made Studebaker a pacesetter in postwar auto trends, will also get the benefits of Studebaker’s strong dealer organization around the U.S. Packard, which has long had trouble getting dealers to take on its big cars in fringe markets, will start off by doubling up with Studebaker to sell Packards in 1,000 towns too small to support a full-time Packard agency. In turn, Studebaker will profit from Packard’s solid engineering and its strong financial position.”
Packard, however, had no such “strong financial position.” It merely had cash in the bank.
Packard’s acquisition of Studebaker was completed on October 1, 1954. Studebaker’s board chairman, Paul G. Hoffman – a business luminary who had served as director of the Marshall Plan in Europe for five years before returning to Studebaker – was given the same role at Studebaker-Packard. Packard executives later maintained that Studebaker falsified information provided to Packard, including its production break-even volume. That may be so, but it is equally true that Packard’s board of directors and officers, including Nance, made no effort to have the Studebaker books independently audited before proceeding with the acquisition.
The truth is that none of that mattered. The acquisition of Studebaker was born of desperation. It was Packard’s only chance. With it, the combination might still fail. It did not matter. Packard was doomed. If it did not combine with Studebaker, Packard would be bankrupt – probably within the year.
Studebaker would post a $12 million loss for 1954, while Packard’s loss was $2 million.
James Nance did not save the Packard brand.
That was not his job. It was not what he was hired to do.
He was hired to save the company.
He did that.
Though saving the Packard brand was one way to save the company, that way would turn out to be impossible.
Yet, Nance still did his job. He did save the company.
Studebaker-Packard would struggle into the 1960’s manufacturing automobiles and incurring losses throughout, except for the few bright years in which it was able to rebody an obsolete model as the Lark and sell it to a public as an economy car. Yet, those accumulated losses allowed Studebaker to avoid income taxation as it reorganized itself into a mini conglomerate of divisions, including Onan generators, STP, Gravely commercial grade lawn mowers, Clarke floor machines, that were profitable. Ultimately, it would exit the automobile business entirely, and – now known only as Studebaker Corporation – be acquired by Worthington Corporation.
In a recent column in the British publication Octane, Jay Leno cites Packard as “a precursor to what happened to the American automobile industry.” He states, “And one of the final nails in the coffin was bringing in James Nance – a man with absolutely no experience of automobiles who came from a background in selling appliances.”
Leno’s wrong about that.
James Nance did not kill Packard. That was done by others.
He saved the company.


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Annexin A1 (ANXA1) protein is involved in the regulation of cell apoptosis.OBJECTIVE:
To construct a short hairpin RNA (shRNA) lentiviral vector targeting rabbit ANXA1 gene and to detect its efficiency of gene silence in osteoblasts.METHODS:
Targeting rabbit ANXA1 gene sequences, a pair of complementary small hairpin RNA (shRNA) oligonucleotides were designed, synthesized, annealed and cloned into pGLV/H1/GFP plasmid digested by BamHI and EcoRI to construct a vector named pGLV-shANXA1. The recombinant plasmid was identified by PCR and DNA sequencing. 293FT cells were co-transfected with pGLV-shANXA1, pGLV/helper-1,pGLV/helper-2 and pGLV/helper-3 to package into lentivirus particles named LV-shANXA1.The titer of virus was tested according to the expression level of GFP. The lentivirus particles were then transmitted into rabbit osteoblasts and its infection efficiency was assessed by flow cytometry.RESULTS AND CONCLUSION:
The PCR identification and DNA sequencing showed that the fragment and nucleotides were in accordance with the target sequence and the shRNA sequence was successfully inserted into the pGLV/H1/GFP vector. The titer of concentrated LV-shANXA1 was 3.8×108 TU/L. The infection efficiency of lentiviral particles was 80% at multiplicity of infection (MOI) of 50 and 95% at MOI of 100 in osteoblasts after puromycin selection. Real-time PCR and Western blot results showed that the expression of ANXA1 in LV-shANXA1-901 infected osteoblasts were lower than that in the blank control, negative control, and other LV-shANXA1 infected cells (P < 0.05), it could achieve 71.2% interference efficiency at MOI of 50. The results demonstrate a lentiviral shRNA expression vector targeting the ANXA1 gene is successfully constructed and it can knockdown the expression of ANXA1 in osteoblasts.RESULTS AND CONCLUSION:
Liang BW, Pan XY, Zhao JM, Yin GQ, Hu F. Construction of short hairpin RNA lentiviral vector targeting rabbit Annexin A1 gene and identification of RNA interference efficiency. Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(11): 1954-1958.


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Deaths in Wealden where Covid-19 was a factor were at their lowest level since late November, according to data published yesterday (March 30).
The figures show that in the seven days to March 19, one person died in hospital.
The last time there was only one death in a seven-day period was in the week ending November 27.
Since then more than 280 Wealden people have died where Covid-19 was mentioned on the death certificate.
These figures show the number of deaths involving coronavirus (Covid-19), based on any mention of Covid-19 on the death certificate.
The Wealden deaths occurred up to March 19 but were registered up to March 27.
UckfieldNews.com maintains its own datasets relating to Covid-19 in Wealden and Uckfield. They are built using published sources, generally the Office for National Statistics (ONS) and the UK Government.
Cases (infections) are of people with at least one positive Covid-19 test result (either lab-reported or lateral flow device)
We generally report Wealden case numbers on a Monday and deaths on a Wednesday


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Surface aquarium plants are particularly useful: They leach nitrates (fish waste) directly from the water column via their beautiful trailing root systems, and they provide a sense of safety and shelter for your fish. But beware placing them in aquariums
Setting up a freshwater aquarium is not as hard as you might think! Need some helpful advice? Are you new to this hobby but need a few starter tips? Whether you’re a beginner or an aquarium enthusiast, you’ve come to the right place!


Bio-Logic distributes the first CD microplate reader on the market
Hinds Instruments names Bio-Logic Science Instruments Exclusive Worldwide Distributor for new CD MicroPlate Reader product
Hinds develops circular dichroism instrument for high throughput screening of chiral pharmaceuticals and strikes distribution deal with Bio-Logic Science Instruments.
Hillsboro, Oregon, July 20, 2017 – Hinds Instruments, a leading global supplier of photoelastic modulators (PEMs) and PEM-based instrumentation, and Bio-Logic Science Instruments today announced that they have entered into an exclusive marketing and sales distribution agreement covering Hinds’ new CD Microplate Reader product. This multi-year agreement combines Hinds’ strength in polarization, chiral technology, and systems development with Bio-Logic’s global distribution reach in the fields of CD spectroscopy and rapid kinetics.
Leveraging more than 40 years of experience designing PEMs for the CD and VCD spectroscopy market, Hinds scientists and engineers developed the product in response to a broad market demand for a CD spectroscopy system capable of reading circular dichroism directly from standard lab micro wellplates. The first commercially-available system of its kind, Hinds’ CD MicroPlate Reader truly delivers on the promise of high-throughput screening for chiral pharmaceuticals.
According to Hinds’ marketing manager Linda Hirschy, “The pharmaceutical industry is experiencing a change in requirements for drugs that exhibit chirality. Chirality is a property of many organic molecules that exist in at least two forms that are mirror images (enantiomers) of each other. Drug interactions for the two enantiomers in biological systems can be thought of as a left and right hand both trying to fit into a left glove. The left hand will be much more successful. In this way, usually only one of the two chiral enantiomers of a drug is therapeutically active. The other may be ineffective or even harmful.”
In nature only the active one of the enantiomers is produced, but in a laboratory or chemical plant it is likely that a mixture of the two will form. As more is understood about the importance of the chiral properties of drugs, the FDA and other agencies have increasingly required that drug companies fully separate, characterize and control the enantiomers they sell. But differences between the two enantiomers are chemically subtle, so separation and characterization are difficult. This has led to a requirement for more analytical methods that can differentiate between enantiomers and help pharmaceutical companies to provide quality control.
While CD instruments have been available for many years, they are all designed to measure the CD of a single reaction product at a time. Hinds’ customers Professor Bart Kahr, New York University and Professor Eric Anslyn, University of Texas at Austin saw the need for a circular dichroism (CD) instrument that could rapidly assess chiral reaction products. In a 2014 article published in The Royal Society of Chemistry, they described a system that would read all 96 wells in a microplate. Kahr and Anslyn then contacted Hinds Senior Scientist Bob Wang about submitting a joint NSF grant application to build such a system. Finally, Anslyn contracted with Hinds to build a system for Anslyn’s lab at the University of Texas. The Hinds CD Microplate Reader is revolutionary in its ability to rapidly “read” the enantiomeric composition of 96 reaction products in a standard laboratory micro wellplate. It can measure the enantiomeric excess of 96 reaction products in less than 2 minutes.
According to Hinds’ senior scientist Bob Wang, “This CD reader eliminates the time-consuming process of transferring the contents from each well of the micro-well plate into a cuvette, and cleaning between each measurement, as is necessary when using conventional CD spectrometers. Furthermore, by avoiding chromatography completely, this instrument is well suited to identifying ‘hits’ quickly using high throughput screening.”
“With this new global distribution agreement, we are very pleased to combine Hinds Instruments’ strength in polarization and chiral technology with our worldwide market reach in the pharmaceutical research industry. We are teaming up with a very strong partner for the global launch of this product. We are looking forward to working together to introduce this exciting new product to researchers around the world who need high throughput CD measurements for chiral pharmaceuticals”, says François Goy, President and Owner of Bio-Logic Science Instruments, Seyssinet, France. Bio-Logic will be the sole distributor for Hinds’ CD Microplate reader worldwide.
Hinds Instruments, Inc. is the world leader in developing and supplying polarization modulation technology for a broad range of applications. With 40+ years of polarization modulation experience, Hinds Instruments PEM-based solutions are proven tools for laboratory and research applications. Hinds’ family of products includes modulators, Stokes polarimeters, Mueller matrix polarimeters, MOKE measurement systems, Exicor® birefringence measurement systems and now circular dichroism measurement systems. For more information, contact www.hindsinstruments.com .
Bio-Logic Science Instruments is a leading designer and manufacturer of high performance laboratory research instrumentation and software. 30+ years of experience in the development and distribution of rapid kinetics and spectroscopy research instrumentation provides Bio-Logic with deep market insights as well as product and application knowledge. Today, that commitment continues through the market leading MOS-500 Circular Dichroism spectrometer and the latest advances in micro-volume stopped-flow mixers. Product-lines from Bio-Logic also include electrochemistry research potentiostats with built-in Electrochemical Impedance Spectroscopy (EIS), Frequency Response Analyzers for materials analysis, Battery Cyclers and Scanning Electrochemical Microscopes. For more information, contact www.bio-logic.net.


Samsung has recently launched the convertible 2-in-1 laptop, the Notebook 7 Spin in US. The notebook is available in two screen size variants, 13.3 inches and 15.6 inches respectively. Both the variants are sold in enterprise and as well as consumer editions.
The notebooks offer Windows 10 Pro out of the box (consumer version comes with Windows 10 Home). The 13.3-inch model is powered by a 2.30 GHz Core i5 6200U CPU. The 13.3-inch variant has a Full HD display, Intel HD Graphics 520, 8 GB RAM at 2133 MHz, and a 500 GB mechanical HDD.
On the other hand, the 15.6-inch version is powered by the 2.50 GHz Core i7 6500U CPU. The 15.6-inch model also has a Full HD display and 8 GB RAM at 2133 MHz, along with a 1 TB HDD and a 128 GB SSD and an NVIDIA GeForce 940MX video card with 2 GB DDR3L memory.
Both variants offer stereo speakers, backlit keyboards, one HDMI out, two USB 2.0 ports, one USB 3.0 port, and a USB Type-C port. The 13.3-inch Notebook 7 spin is now available for $899 (INR 60,380) and the 15.6-inch for $1,299 (INR 87,250) from Samsung’s business site. Consumer variants of both notebooks are up for pre-order on Samsung’s website, with deliveries going out from end of July.
Source: Windows Central


Automatic Channel Allocation
The best allocation of channels to the various networks is determined automatically by the control system during the installation process.
The WiFi built into the Raspberry Pi is used to automatically scan the signal strength of each WiFi channel, which also covers most of the ZigBee channels. On this basis, the control system determines the optimum channels for use by the Raspberry Pi WiFi and the ZigBee networks automatically. In most home, there should only be one main WiFi network, so an algorithm determines the channel allocations for the networks to be used by the control system.
If there is more than one home WiFi channel, such that the system is unable to locate a sufficient number of channels with low radio noise levels, then this is reported back to the user.
Once the channels have been allocated in this way, and devices have been attached to the networks, these can be changed only by repeating the installation process. This entails re-joining every device to their networks, which is when they scan the channels automatically for their network.
In theory, it should be possible for the hub software to instruct the devices attached to a network to search for a new channel, and for the hub to switch to that channel. This enables the channel to be moved, when the current channel cease to have the lowest background radio noise.
In practice, the procedure is too complicated for most users, so the preferred approach is to disconnect all of the devices, create a new network, and then re-attach the devices. This should be a very rare event, and, when the need does arise, the control system alerts the user accordingly.


Morgan Freeman intones in a movie trailer: A family of castaways is swept out to sea, to land on a mysterious island.
What happens next on the island of Madagascar, in the Indian Ocean, takes millions of years.
The family of “proto-lemurs,” washed out to sea from Africa aboard a floating raft of vegetation, evolved into hundreds of species.
A documentary opening Friday at the Riverfront Park Imax Theatre tells the story of the animals’ survival – and decline. After humans arrived on Madagascar 2,000 years ago, some lemurs became extinct. That included all the giant lemurs, some of which were as big as gorillas, according to a press release from Warner Bros. Pictures and Imax.
“Island of Lemurs: Madagascar” follows primatologist Patricia Wright, whose mission is to help lemurs avoid extinction. But lemurs – which can be as tiny as the pygmy mouse lemurs and as big as the 3-foot-tall indris – are the stars.
They leap, hop, gallop, dance and sing on the screen in what director David Douglas has called the primates’ “come-from-behind survival story.”
When: The 39-minute film will run through August. Friday to April 13, it starts at 2:30 p.m. daily; check http://spokane riverfrontpark.com for later showtimes.
Where: The Riverfront Park Imax Theatre is in the U.S. Pavilion area of the downtown park.
Tickets: Available at the theater. $8.50 for adults, with $1 discounts for seniors and members of the military; $6 ages 12 and younger; free for children 2 and younger. Group discounts available; book in advance by calling (509) 625-6746.
Online: Download children’s activities and educational materials at http://islandoflemurs.imax.com.
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NEWSPAPER TITAN: THE INFAMOUS LIFE AND MONUMENTAL TIMES OF CISSY PATTERSON
By Amanda Smith
Alfred A. Knopf, $37.50 696 pages
A serious biography of Eleanor Medill “Cissy” Patterson was long overdue. During the 1940s, she was part of the “royal family of American journalism.” A descandent of abolitionistJoseph Medill, owner of the Chicago Tribune, sister of Joe Medill Patterson of the New York Daily News and cousin to Col. Robert R. McCormick of the Chicago Tribune, she outshone them all with her flamboyance, grit and intelligence.
As Amanda Smith writes in this handsomely produced door-stopper of a book, the course of Cissy Patterson’s early life might have been lifted from the pages of Henry James or Edith Wharton. Beautiful, rich and headstrong, against the objections of her family she married Josef Gizycki, a Polish count with connections to the Austro-Hungarian and Russian courts. Four years later, she had to flee from him, still bleeding from another of his beatings. It took the intercession of President William Howard Taft and Tsar Nicholas II to gain her freedom, along with that of her daughter, whom the count had kidnapped. The melodramatic divorce made the news.
Her second marriage to Elmer Schlesinger, a Chicago lawyer, proved unhappy, but his death left her even richer. Such lavish wealth might have settled Cissy for a life of play. Instead, in her roles as heiress, countess, actress, divorcee, dude rancher, big-game hunter, novelist and champion equestrian, she found real happiness in her work as a newspaper publisher. In 1930, she took over William Randolph Hearst’s foundering Washington Herald.
Arriving at the office refreshed from galloping her horse through Rock Creek Park, she was a hands-on editor. She built up the paper with improved typography, cartoons, layout and writing by encouraging women reporters and raiding the staff from the rival Washington Post.
Then she bought Hearst’s evening paper, the Washington Times [Editor’s note: The paper is not connected to the current paper of the same name.], and merged the two, becoming the first woman editor, publisher and sole proprietor of a major metropolitan daily newspaper. By 1945, the Washington Times-Herald, with its round-the-clock daily editions (a precursor of the 24-hour news cycle) was clearing more than $1 million in profit annually.
Isolationist and conservative, she agreed with titans Hearst and McCormick that the United States must forget Europe’s troubles and concentrate on America. Few members of the New Deal escaped the lashing of her tart tongue. For their own part, writes Ms. Smith, many cherished their Times-Herald epithets as badges of honor.
In a stunt reminiscent of another reporter, Nellie Bly, during the depths of the Depression, Cissy once left the luxury of her Dupont Circle mansion and disguised herself as a destitute beggar, eating handouts. Her reporting gig introduced her and her readers to the widening gap of rich and poor. Her feature series, “Suffer Little Children,” examined conditions in the District of Columbia’s schools, resulting in the initiation of a hot lunch program. She also pushed for the clean-up of the Potomac River and the protection of the watershed’s fish and wildlife.
In 1941, she charged that President Franklin Roosevelt “had lied us into war.” Like many of her contemporaries, including the journalist H.L. Mencken, who had experienced the propaganda of atrocities of World War I, she initially thought the Holocaust was another instance of the same. When photos of the liberated German concentration camps appeared in 1945, the horrified publisher burst into “unaccustomed tears.”
Cissy adored animals - more than people, groused daughter Felicia. She traveled everywhere with her horse, Exclusive. In old age, when those closest to her were dead or estranged, Cissy’s poodles and horses provided friendship and love. Even after her death in 1948, she still made the news as relatives contested her will.
Amanda Smith has done a herculean job of researching the primary and secondary sources. Unfortunately, there is not a factoid the author does not offer. Too often, characters are introduced with a resume of years and dates that clutter the text. We do not need to know (as on Page 351) what said the masthead of “Editor and Publisher” magazine - another instance of the biographer cramming meticulous archival detail into a narrative that threatens to tangle the reader from its flow. While accuracy and atmosphere are paramount to any biography, selection is essential.
Nonetheless, for those who wish to acquaint themselves with (or remember) the personalities and flare of Washington’s past, “Newspaper Titan” takes you on that journey. Alice Roosevelt Longworth, another society powerhouse, summed up her contemporary best: “I said a lot of things, but Cissy DID them.” They were amazing women, these: tough, witty, smart, rich, well read, well dressed. Spending time with them in this absorbing and fascinating book is well worth the effort.
• Marion Elizabeth Rodgers is the author of “Mencken: The American Iconoclast.”

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Does your commercial establishment rely on an ice maker? Complete Air Conditioning & Refrigeration, Inc. will help you make sure this installation remains functional, clean and safe at all times. We frequently work with restaurants to keep their ice machines working flawlessly.
Installation and Repairs
As the leading local provider of commercial ice maker repair in Panama City, FL, you don’t have to look far to get the service you need for your machine. We deal with everything from jammed ice machines to contaminated water lines and beyond. Whatever the nature of the problem, count on us to get to the bottom of it, fixing it to restore long-term functionality to your investment.
In addition to repairing existing ice machines, we also offer commercial ice maker installation in Panama City, FL. We’re familiar with the requirements of most models and can help you to install a brand-new one in your facilities, or retrofit an old one. We facilitate all parts of the installation and ensure the machine is working perfectly before leaving the site.
Not sure why your ice machine has stopped producing cubes? Worried about contamination in your water lines? Problems with a machine overheating? Troubleshooting is important when it comes to determining the right solution. Our team takes the time to go over all of the issues your machine is experiencing. Once we know what we’re dealing with, we can provide parts and service that remedy it properly. The result is a functioning machine and a sound investment.
Get Service Today
If your ice maker is showing signs or symptoms of an internal issue, let our team get to the bottom of it quickly. Give us a call today at 850-785-8346. We’ll be happy to inspect and service your machine, so you and your customers can get back to using it as it was meant to be enjoyed.


First unveiled earlier this year at the 2019 Geneva Motor Show, SsangYong Berjaya Motor Philippines has finally unveiled the all-new Korando alongside the refreshed Tivoli. The Korando is SsangYong’s challenger to the compact (C-segment) crossover SUV segment and it brings to the table an all-turbocharged powertrain to challenge class stalwarts such as the Honda CR-V, Subaru Forester, Hyundai Tucson, just to name a few.
Redesigned from the ground up, the all-new Korando’s exterior is a huge departure from its rounded predecessor. It emphasizes its robust character through a new grille and headlight treatment. The contemporary exterior design features sharp LED headlamps with LED daytime running lights for the Diesel Premium variant as well as slick alloy wheels that give the Korando an extremely handsome look. Meanwhile, LED foglights are equipped as standard on all diesel variants.
Likewise, the interior is also vastly improved from its predecessor, featuring a host of premium soft-touch materials and interesting design details. As for features, all variants get cruise control and heated power-folding mirrors. Diesel variants get upgraded to an 8-inch touch screen infotainment system with Apple CarPlay and Android Auto functionality as well as a reverse camera. The top-of-the-line Diesel Premium variant gets all the bells and whistles including a highly-configurable 10.25-inch fully digital instrument cluster, passive entry with push-button start, and 8-way power-adjustable driver and front passenger seats.
Under the hood of the all-new Korando are two turbocharged engines. The entry-level variant is powered by a 1.5-liter inline-4 turbocharged and direct-injected petrol engine that produces 163 hp and 280 Nm of torque. The more expensive diesel variants have a 1.6-liter inline-4 turbo diesel engine that produces 136 hp and 324 Nm of torque. Both engines are solely mated to a 6-speed automatic transmission driving the front wheels.
As for safety, all Korando variants are equipped with dual SRS airbags and ABS with EBD, while higher variants get a reverse camera and front & rear parking sensors.
“The Korando was developed with two goals in mind,” shares Mr. Japeth Castillo, President of Ssangyong Berjaya Motor Philippines. “First, we wanted an SUV with improved fuel efficiency. Second, we wanted to give our customers even better power delivery than before. The fourth-generation Korando is the result of years of research, development, and refinement.”
“We wanted to deliver a vehicle that had a premium fit and finish, but at a more affordable price compared to the competition,” Castillo adds.
The SsangYong Korando is now on sale at Auto Asia Sta. Rosa and SsangYong Otis, Manila with the following prices:
1.5T Sport AT: P1,290,000
1.6 Diesel Sport AT: P1,578,000
1.6 Diesel Premium AT: P1,770,000


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Posted: Jun 27, 2012 6:49 AM CT
Last Updated: Jun 27, 2012 6:48 AM CT
Saskatchewan residents braved the elements Tuesday night to capture dramatic photos of lightning and swirling clouds.
Young Saskatchewan Roughriders fans weigh in on 0-8 start
Meet Christy Climenhaga, CBC Saskatchewan's meteorologist.
Waning days of summer
Smoke prompts air quality statements for half of Saskatchewan
SUV strikes, kills 15-year-old near Borden, Sask.
Fringe parties fight to spread message, sway swing ridings
Heinz Pear Green Bean Mango baby food recalled
New wildfire policy in the works after Brad Wall's trip to northern Saskatchewan
Hoping to see party leaders in your town? Only if they have something to gain
Foster children in hotels: Advocate stunned
Summer Invasion festival underway in Regina
Cheat bidders beware: U of R research aims to sniff out online auction fraud
School fundraisers: Are you ready for bake sales?
Childhood memories lost to Hurricane Katrina: Korey Williams
Saskatoon police investigate death of driver after 911 delay
Chris Kelades celebrates UFC win, aims for third fight in 2015
Building with opera theatre, jail cells for sale in Sask.
Truck driver charged in crash that killed 3 Saskatchewan teens


Since the Air Force retired its EF-111 platforms in the 1990s, the service has not flown a dedicated standoff/escort electronic attack aircraft. But at NAS Whidbey Island, Wash., a group of electronic warfare officers continues flying the mission, partnering with the Navy to carry out EA-6B Prowler and now EA-18 Growler operations. “We’re the only tactical [Air Force electronic warfare] game in town here,” said Lt. Col. Karl Fischbach, 390th Electronic Combat Squadron commander at Whidbey Island, in a late June interview. The unit places Air Force EWOs in the back of Navy Prowlers and Growlers and serves as the Air Force component of the US military’s joint electronic attack program. While at one time Air Force pilots used to fly in the exchange program, since 2005, the Air Force supplies only EWOs. Currently the 390th ECS has 13 EWOs supporting six squadrons at Whidbey Island, but the numbers are in flux as the two-seat Growlers come online, replacing the four-seat Prowlers. After input from theater commanders, the Navy decided to stand up its first three Growler squadrons as land-based expeditionary units and not as part of carrier air wings, noted Fischbach.
The U.S. supports “a stronger and more capable” European defense, Defense Secretary Lloyd J. Austin III said during an Oct. 22 press conference in Brussels—but that defense should not duplicate the functions and capabilities of the NATO alliance.