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text:
in anthology My Spellbound Heart
Lost on the Scottis moors, Bridget MacKay enters a magical realm...and comes face to face with Artair, the handsome prince who has long haunted her dreams. In an enchanted world brushed with moonbeams and stardust, Bridget loses her heart. But is her lover real...or merely a mirage that will vanish with the dawn?
My Spellbound Heart (1994)
A novel by Amber Kaye
Publisher: Zebra Books
Click here to
purchase on Amazon.
Updated January 31, 2008. Copyright © 2006-2008 Georgina Devon. All rights reserved.
|Provided by website design company .|

domain: artistic


text:
The Final Four is set, and on the right side of the bracket we have 4-seed UConn representing the West Region, and 5-seed Miami representing the Midwest.
Miami pulled off back-to-back upsets over No. 1 seed Houston and No. 2 seed Texas in the Elite 8 to book their first trip to the Final Four in school history.
UConn steamrolled their region, capped off by decimating 3-seed Gonzaga 82-54 to advance to the Final Four for the first time since 2014.
Continue reading for the best parlays for Miami vs UConn in the Final Four.
UConn vs Miami Best Same Game Parlay
UConn vs Miami Best SGP (+170) • DraftKings Sportsbook
WAGER: 1 Unit
- UConn Moneyline (-250)
- Over 149.5 Total Points
UConn is the most talented and best team remaining in the tournament.
The Huskies have an incredibly balanced lineup and have launched up the KenPom rankings to the top spot, now sitting at third in offensive efficiency and 11th in defensive efficiency.
Adama Sanogo has been a dominant force in the interior, averaging 20 points and 9.8 rebounds per game in four tournament games. As a team, UConn has shot 41% from three in the tournament.
Sophomore Jordan Hawkins has potentially played himself into the NBA Draft Lottery with an impressive tournament, and combo-guard Andre Jackson Jr. has done it all, averaging eight points, eight assists, and seven boards per game.
They’re a well-oiled machine and have proven it by winning their four tournament games by an average of 22.5 points.
Click to read the rest of our UConn vs Miami Final Four bets:
Miami has one of the best offenses in the country and is averaging over 80 points per game in the NCAA Tournament. All five Miami starters scored double digits in the win over Texas, and they’ve had three different leading scorers in four games.
Even against UConn’s elite defense, the Hurricanes will be able to score. They love to get out and run with their impressive guard play anchored by junior Isaiah Wong and sophomore transfer Nijel Pack.
The Huskies will pull through and survive late to advance to the national championship, but this should be a high-scoring affair.
UConn vs Miami Longshot Same Game Parlay
UConn vs Miami Longshot SGP (+1000) • DraftKings Sportsbook
WAGER: 0.5 Unit
- Both Teams Over 79.5 Pts (+550)
- UConn -2.5 (-185)
We’ll need a perfect game to hit this Final Four long shot parlay, but considering these two offenses, it’s very much a possibility they both break 80 points.
Both teams have clicked on all cylinders in this tournament, but we’ll also need the pace to be up-tempo. With Miami and their guards, the pace seemingly always finds a way to increase.
UConn will be willing to match the tempo, and with the shotmaking and depth on both sides of the floor, it’s entirely possible this game is back-and-forth for all 40 minutes.
With the way Miami hasn’t quit this tournament — they had double-digit comebacks against Texas and Drake — there’s also the possibility of overtime which gives us another shot at hitting this longshot (+1000) parlay.

domain: game


VERNON — Libraries across the country, internationally, and in the local area celebrated ‘Take Your Child To The Library Day,’ on Feb. 1.
The Rockville Public Library Children’s Department hosted crafts and storytime all day, and Tolland Public Library had a scavenger hunt as well as books and art projects.
Ellington’s Hall Memorial Library was transformed into a 26-hole miniature golf course, and also hosted face painting and a variety of food offerings
“It was another fantastic day at our 5th annual Mini-Golf at the Library event, with 448 happy golfers of all ages, and countless parents who tagged along to watch their kids golf,” said Francie Berger, reference librarian/programming coordinator at Hall Memorial Library.
“We had record attendance, record raffle ticket sales, and a record amount of food consumed,” Berger added. “The weather cooperated once again and things could not have run more smoothly.”
The special day was created in 2011 by two librarians from Connecticut, and is celebrated on the first Saturday in February.
For more information, visit https://www.ctlibrarians.org/page/take, or your local library’s website.


text:
- What Is the Meaning of the “Lemon Tree” Song by Fool’s Garden? - November 24, 2023
- What Is the Meaning of “Vultures” Song by Kanye West & Ty Dolla $ign? - November 22, 2023
- What Is the Meaning of “THEE PERSON” Song by Pardison Fontaine? - November 19, 2023
Ariana Grande – How I Look On You Lyrics Meaning
Charlie’s Angels are back in town and are set to do what they are best known for – to save the world and in the process, to also conquer it! The soundtrack of the motion picture released on November 1, 2019, and is already setting playlists the world-over ablaze. Track no.8 on the soundtrack is ‘How I look on you’, has a sassy meaning behind the lyrics which is sung by Ariana Grande. The singer is confronting her love interests’ true intentions behind being with her.
The 7 rings singer has been the center of attention ever since she’s had to go through a lot of adversities. Following the Manchester bombing, the demise of her ex-boyfriend Mac Miller, and her recent broken engagement, she’s been emotionally unstable. Despite going through everything she’s been able to stay afloat in the music industry and it’s amazing! Just a while ago, the singer had released a collaboration with Lana Del Rey and Miley Cyrus in the song ‘Don’t Call Me Angel‘ for Charlie’s Angels.
Introduction: How I Look on You Lyrics
In the lyrics of ‘How I Look on You’, Ariana Grande discusses the hardship she’s been going through in order to trust anyone other than herself. More specifically, the singer wonders whether he is by her side for who she is as a person, or her fame and fortune. Every time Ariana enters a new relationship, the effort in the romance section since he begins to distance himself from Ari after he seemingly garners publicity.
I can smell Ariana talking about her previous boyfriend, Pete Davidson. We may never know the truth!
How I Look on You Lyrics Meaning
Let’s dissect the meaning behind the lyrics of the song ‘How I Look on You’ by Ariana Grande section-wise.
Grande is talking to her love interest and is, in fact, stating things on his behalf. He seems to be claiming that he loves her unconditionally and even though the fame that Grande enjoys and often endures, would be difficult to handle, he is ready for the challenge. He sounds like a modest common man who does not want fame and rather is intimidated by it. The girl he has his eyes on is not easy to be with, given the media glare that will always follow her. And he likes her the way she is, or so he claims?
Grande and the boy have moved ahead with their relationship – for real or just in Grande’s mind – has been left open to interpretation. So once together, the couple has gone out to party on the weekend. And inevitably, the two of them make it to the headlines of news dailies! The world is now speculating about who this boy is. Grande has brought him into the limelight. And yes, the boy still claims that he is in the relationship for the singer and not the fame that comes along with it.
And this is when the test of the authenticity of this boy comes into the picture. Her peers appear to be warning the singer that the concerned boy has his own vested interests and his love is not as unconditional as he claims it to be. But Grande brushes aside all such warnings. She requests the boy to show her and the world that he wants her and her alone and not any other hidden selfish gratification.
The singer has been licking her wounds which all her heartbreaks have given her so far. She is hoping against hope that this particular person is a cut above the rest and that he has his love her and not for the way he looks to the world upon being seen with her. Grande croons these lines multiple times in the song to express how much she wants him to want her and not the fame.
We suddenly cut to a couple of weeks after this and the tables have turned and how! The boy has turned out to be a chameleon much like the previous men that Grande has dated. As opposed to his claims, he has hurried to embrace all the name and fame that he can by virtue of Grande’s company. Only he is grabbing all those eyeballs all by himself and has let go of the singer. He seems to have found a place on the silver screen. Grande, regretful and heartbroken, is left wondering if she was just a stepping stone for him.
Conclusion: How I Look on You Meaning
Ariana Grande has been singing about heartbreak and insecurities for a while. She hasn’t been afraid to show her vulnerable side to the world. What do you think is the meaning behind the lyrics of the song ‘How I Look on You’ by Ariana Grande? Do you like the path Ariana is following musically? Can you smell Pete Davidson here? Let us know in the comments section below?
Read the meaning behind the lyrics of the song “How I Look on You” by Ariana Grande on Genius in detail. Also, we have jobs for you if you wish to work with us.

domain: celebrity


Bad Habits that Hurt Your Brain
Human beings are creatures of habit, but not all habits are beneficial to our health, particularly our brain health.
Some habits may seem innocuous at first glance, but they may have adverse effects on our brain, leading to cognitive decline, memory problems, and even mental illnesses.
In this article, we will discuss bad habits that hurt our brain and present some ways to break these habits.
Breakfast is the most important meal of the day. It provides essential nutrients and energy that our body needs to function correctly. However, many people skip breakfast to save time or calories, not realizing that this habit is detrimental to their brain health.
Studies have shown that skipping breakfast can impair cognitive function, memory, and attention, especially in children and adolescents. Skipping meals, in general, can also cause a drop in blood sugar levels, which can lead to irritability, fatigue, and difficulty concentrating.
To avoid skipping breakfast, try to plan your meals ahead of time. You can prepare overnight oats, smoothies, or breakfast burritos that you can quickly grab and go in the morning.
If you don’t have enough time to eat before work or school, try to wake up fifteen minutes earlier to make time for breakfast. Additionally, If you find yourself skipping meals frequently, consider seeing a nutritionist or a healthcare professional.
Lack of sleep
Sleep is essential for our overall health, but it is especially crucial for our brain. Our brain uses sleep to consolidate memories, repair cells, and remove toxins.
However, many people still underestimate the importance of sleep and compromise on the quality and quantity. Inadequate sleep can cause a range of problems, including poor memory, lack of concentration, and mood swings.
Chronic sleep deprivation can also increase the risk of developing mental health conditions such as depression and anxiety.
To improve sleep quality, you can try the following habits:
Establish a consistent sleep schedule and stick to it, even on weekends.
Avoid using electronic devices before bedtime.
Create a peaceful and comfortable sleep environment. Keep your bedroom dark, cool, and quiet.
Exercise regularly but avoid intense workouts close to bedtime.
Avoid caffeine and alcohol before bedtime.
If you struggle with sleep, consider talking to a healthcare professional.
Many people pride themselves on their ability to multitask, but research shows that multitasking can harm our brain. The human brain is not wired to handle multiple tasks at once, and trying to do so can cause stress, fatigue, and a decrease in productivity.
Multitasking can also interfere with critical thinking and decision-making abilities, leading to poor judgment and mistakes.
To increase your focus and productivity, try the following tips:
Prioritize your tasks and work on each task separately before moving on to the next one.
Avoid distractions such as social media, email notifications, and phone calls. Consider turning off your phone or using apps that limit your access to social media and other apps.
Take breaks regularly and move around to reduce fatigue.
Practice mindfulness exercises, such as deep breathing or meditation, to improve your attention and concentration.
A sedentary lifestyle is another bad habit that can harm our brain and overall health. Sitting for extended periods can slow down blood circulation, leading to a decrease in oxygen and nutrient supply to the brain.
This can cause cognitive decline, memory problems, and an increased risk of developing dementia and Alzheimer’s disease. Sedentary behavior can also cause physical health problems such as obesity and cardiovascular disease.
To avoid a sedentary lifestyle, try to incorporate physical activity into your daily routine. You do not need to engage in intense workouts to reap the benefits of exercise. Here are some tips:
Use the stairs instead of the elevator.
Take a walk during your lunch break or after dinner.
Use a standing desk or take frequent breaks to stand and stretch.
Engage in activities that you enjoy such as dancing, swimming, or gardening.
Join a fitness class or find a workout buddy to keep you motivated.
Bad habits can harm our brain and overall health. Skipping breakfast, lack of sleep, multitasking, and sedentary lifestyle are some of the habits that we need to break to improve our brain health.
By implementing healthy habits such as regular exercise, proper nutrition, and quality sleep, we can promote brain function and cognitive performance. However, breaking bad habits is not easy, and it requires patience and commitment.
By making small changes to our daily routine and seeking help when necessary, we can build healthy habits that will benefit our brain and well-being.


text:
TAMPA, Fla. - Amanda Gary has been a foster mother for years. Her attorney, Rick Escobar, says children are her life.
"I would characterize Amanda Gary as the foster mother of the decade," said Escobar.
Gary was arrested for aggravated child abuse of a six-week-old foster child. Prosecutors say the baby’s legs were broken and the baby was rushed to the hospital. Medical staff alerted authorities who later arrested Gary.
But Escobar says, there was a series of mistakes made by medical staff and a rush to judgment by child protection investigators.
"Frankly, it’s an embarrassment of an organization in the state of Florida," said an impassioned Escobar.
Escobar says a thorough examination of the baby’s medical records show the child may have had a bone deficiency disorder that led to the baby’s broken bones. Escobar said this wasn’t child abuse.
"The baby was suffering most probably from a nutritional deficiency," explained Escobar.
However, prosecutor Melissa Grajales refuted those claims.
"All the hospital records indicate that child was born healthy a healthy weight and had no issues," said Grajales.
Gary has been out on bond since her arrest. However, under bail conditions, she has not been allowed to be alone with her own biological children. After laying out serious failures and issues in this case, Escobar urged the judge to lift those restrictions. Hillsborough Judge Samantha Ward did just that.
Outside the courthouse, Escobar said his client is one step closer to complete vindication.
"The damage was done the moment she was arrested unjustly her life will never be the same, " said Escobar.
CONNECT WITH FOX 13:

domain: news


text:
August 2 The Bach Parodies
Christ Church Cathedral
Artists: Jessica Korotkin, cello and director; Majka Demcak, violin; Elana Cooper, viola, & Diederik van Dijk, cello
While the concept of ‘parody’ is today associated with humour and satire, in the context of music composition, it refers to the creative process of recycling musical material. This program pays homage to Bach, showcasing an eclectic variety of Bach-inspired musical parodies. The concert includes works by J S Bach, Mozart, Gounod, and Korotkin.
You can read more about Jessica Korotkin and Bach Parodies in this article from Early Music America Magazine.
This concert is generously sponsored anonymously

domain: entertainment


text:
OCEAN (USA) ST (1969 hippies, lost psych folk gem) CD & LPLOLLIPOP SHOP
Recorded in 1969 by an NYC-based hippie group, comprising ex-members of The Family Of Apostolic, a long lost psychedelic folk-rock gem sees its first ever vinyl release!
Featuring gorgeous male and female vocals and virtuoso playing, the songs (originals mostly!) reveal influences from the British late '60s folk boom, Middle-Eastern music and traditional US genres s.a. bluegrass. Includes and insert with liner notes and archival photos.
Second press on black vinyl, includes a 2020 CD by band member John Townsley ('The Old Sailor')


text:
Fiona de Londras (University of Birmingham) and Kanstantsin Dzehtsiarou (University of Liverpool) have written a new book entitled Great Debates on the European Convention on Human Rights. The book was published with Macmillan Publishers and was written for higher education teaching. This is the summary:
'This engaging textbook provides a critical analysis of the legitimacy and effectiveness of the European Convention on Human Rights and its practical operation. In a succinct way, the book investigates questions around the legitimacy of how the European Court of Human Rights develops its law, the obligations of states to comply with its judgments, the adequacy of the Convention in securing basic goods, and the effectiveness of the system in protecting rights ‘in the real world’. It assesses some under-explored areas of the Convention that are often overlooked. Presenting a number of debates about the legitimacy and effectiveness of the system in a provocative and critical style, this book encourages debate, discussion, and self-reflection on how, when and why the Convention protects human rights in Europe.
An ideal text for Law students at English and Welsh universities and higher education institutions taking a module in The European Convention on Human Rights (LLB or LLM level), and for GDL/CPE students and those taking the postgraduate LPC training course.'

domain: library


Wandsworth will mark Grenfell anniversary
Published: Wednesday 13th June 18
The council will join the London-wide commemoration in the early hours of tomorrow morning (Thursday) marking the first anniversary of the Grenfell tragedy.
Wandsworth town hall will join other landmark buildings across the capital to be illuminated in green just before 1am to mark the moment 12 months ago that the fire began.
Battersea Power Station will also take part in the commemoration, while across the capital, the Houses of Parliament, Trafalgar Square, Tower Bridge, City Hall, The London Eye and BT Tower are among a host of others that will also turn green – the colour chosen by survivors’ support group Grenfell United, which came up with the idea.
All these buildings will be bathed in green light from 1am until sunrise tomorrow morning and then again later in the day between dusk and midnight.
Wandsworth Council leader Ravi Govindia said: "The tragic loss of life at Grenfell unfolded a year ago but the memories of that awful night are still fresh in the minds of all Londoners. As a council we want to show our support for the Grenfell community and all those affected by that terrible and unprecedented event.”


And the value of the artworks can’t be lower than 1% of the price paid for the land lot
The so-called ‘Children’s Biennale’ takes place at Forte Marghera
21 May-21 November 2021 – these are the dates indicating the start and ending of the 17 International Architectural Exhibition that will take place in the city of Venice, a forum where visitors can admire the latest creations and innovations in that field. The slogan of this year’s event is ‘How will we live together?’.
Organizers, however, have also prepared a spin-off of the main event aimed at children and aptly named ‘How will we play together?’. This one is presented at Forte Marghera – a historic fort, which since 2018 has been used as the grounds for special projects that are part of the Architecture and the Art Biennales.
Coaxing young minds into thinking about design and architecture
The project aimed at kids features different installations, made of wood and steel, which confront the youngsters with the need to make a choice, as is basically what one has to do in life, as well. These features invite children to play, climb, hide and explore.
Roberto Cicutto, the President of the Architecture Biennale, who as at the unveiling stated: “Playing is the first great experience of life. Many characteristics of our personality depend on changing the perception of the game and on having to stop playing at a certain point because we grow up.
A section of the Biennale dedicated to children and play with the prophetic title “How we will live together”, thought out before what happened in the past year and a half, could not ignore such an important place and activity. I want to express my appreciation for this space, dedicated to culture and work not in abstract terms, but in a way where people can find themselves ".
The exhibition at the Children’s Biennale consists of five installations: Off Fence (2020), The Playful Eight (2021), Social Equilibria (2021), Field of Lines (2021) and Level-313.9 (2021).
The price of monthly passes, however, will remain the same so that regular commuters won’t have to worry
The design of the new bills will be chosen in 2026
The first-of-their-kind, the two-wheelers have already been turning heads in France
Linköping (Sweden) wins in the European Rising Innovative City category
Nijlen wants to be known as a bee-friendly town, which transforms words into actions
It will cost 39, instead of the regular 49 euros, in a bid to make public transit even more accessible
The Spanish island town gets high marks for creating an urban environment fully inclusive of people with disabilities
The Dutch capital is vigorously trying to remake its image and reputation and put forward what makes it a breathing livable city
Apply by 10 November and do your part for the transformation of European public spaces
This one could be a real game-changer for our built environments and the way they look
The practical art objects are competing for one of the 2023 New European Bauhaus Prizes
An interview with a member of the No Hate Speech Network team
A talk with the first man to circumnavigate the globe with a solar plane, on whether sustainability can also be profitable


text:
Cam Levins brought new meaning to the phrase “go the extra mile” at the Armory Track Invitational on Jan. 31 in New York.
The 25-year-old Black Creek distance runner was the star of the meet on Saturday, winning the mile race, taking a brief rest, then winning the two-mile event.
Levins won the mile in 3:54.47 (a world-leading time for this season that missed Nate Brannen’s Canadian indoor record by about four-tenths of a second and was a personal best by three seconds). Chris O’Hare was second in 3:57.26.
In the 30 minutes between races, Levins said he, “changed my shoes, sat down for a second, went downstairs for a jog and basically got some water. I then put on my spikes and got back on the track. It went by pretty quickly.”
Levins then completed the double by defeating 2012 Olympic silver medalist Galen Rupp, his Nike Oregon Project club teammate, in the two-mile race. Rupp had the lead entering the final lap before Levins made his move.
“When I got to there, I’m like, ‘Oh, man, Galen’s not pulling away from me; maybe I got a shot at it,’” Levins told reporters afterward. “I thought he was just going to start hammering that last lap, frankly. And when he didn’t, I’m like, ‘Oh, I’m still here; maybe I can make a move on him.’ And then he didn’t really respond,” Levins said.
Levins’s winning time was 8 minutes 15.38 seconds, with Suguru Osako of Japan second in 8:16.47 and Ben Blankenship of Nike Oregon Track Club third in 8:16.53. Rupp, the runner-up in the 10,000 metres at the 2012 Olympics, finished fourth in 8:17.24.
“I feel the strongest and fittest I ever have,” Levins told reporters after his second race. “I felt fresh and good, I knew I was fit, but I don’t know if I was expecting to come back and run a good two-mile after my mile, that’s for sure.”
Levins, who won bronze in the 10,000 metre race at last summer’s Commonwealth Games, has run doubles in the past. While at Southern Utah, he won both the 5,000 and 10,000 metres in his final NCAA season, earning the Bowerman Award as the U.S. college’s top track athlete. He also ran both events at the 2012 London Olympics.
Next up, Levins is scheduled to run the 5,000 metres at the Millrose Games, Feb. 14 in New York.

domain: sports


text:
The Journeymaker visits the Marsh Oracle
uncurl your tongue’s fiddlehead
let me hear the tale of Long Shadow
in your voice
that ripened underground
Stitch for me clouds of white linen and storm-black damask:
embroider them with lightning,
give me the tokens of brass in your hair:
elk and hare and chickadee,
their eyes of tourmaline to smooth my tongue
This brass that weighs my hair
down to this waterlogged earth
was woven in there by my lover,
the one who tarries long,
the one I fear has lost his way.
If I’m to give you of those tokens,
and he’s to come,
then promise me that you will send him in my steps.
I make no bargains with immortals;
my tale will die—
perhaps to be be reborn
inside those swollen waterlilies,
inside the marsh, unreachable by winds.
These clouds I’ve sewn with lightning,
these cloths of snow with hare-stitched paths,
unwound the tokens from my hair.
Then sit with me,
land-stitcher, Journeymaker—stay from motion
on gurgling ground that named itself
with water grown too green with life
before your wars were born:
on this disloyal ground,
The Marsh Oracle Tells about the Child
Across the winter grows the shadow long,
across these bitter fields, where hare and deer
leap over bones grown through with dandelion
there, buried underground
the wars of past and future intertwine
in caves like marriage beds, in sheets dug out by moles they lie
in ditches sunk through earth,
and birth Long Shadow
the child with hair of ash and abalone
and skin of bark, and sunken cheeks of rue,
born of so many parents, and of none.
The child whose voice is rotten hair,
whose hair is screech-owl wings,
whose eyes ensnare your wildest fear
and skin it—
yes, Long Shadow.
What is displaced from memory, pushed out,
made vanish, buried, does not always die.
I’ve made a note of this to mortals:
that wars once fought will still reverberate
through frozen earth, through thaw, through many lives
warped by those deeds
—do you suggest that those who dwell above
should aid the child, an orphan of too many parents,
of battlefields like tangled snakes?
You’ve made me laugh with your inane pontificating.
Give me a lantern for my hurts!
Would you agree to aid a child who wanders like a ghost
and steals the souls of the unborn? How will you go
about this help? To keep it warm,
whose children will you choose, and spill their blood
to feed Long Shadow?
There must be another way.
What way do you envision
while battles suffocate below,
yet are still living? All those hatreds that have grown
like poison ivy through the hearts of city dwellers
and village folk—where do you think they come from?
The child, the child, it is a strangleweed,
the child’s a thief, the child’s a piper
who walks through towns and sings the young away
to join its parents under loam and hedge
to die and rot and still remain alive
where voices call from stolen earth.
What’s the solution? I must know—
Is that the knowledge you would gain from me,
a warmth by which it would be pacified,
a comfort that would make the land forget
your lover’s bloody deeds?
All that was done against my will.
These tokens I have felt
with mold-wet fingers
elk and chickadee—you say he braids your hair
with much humility, and is housebroken;
Your lover’s bloody deeds have birthed the wars.
You’ll gain no better answers from the marsh,
for here unwanted truths have come to rot,
disdained by people who would rather hope,
and hope in vain, than swallow truth.
I swallowed from your truth.
My leave I’ll take—
and those brass ornaments, to melt away,
be vapor in the sun. I owe you nothing
except my hearing of your truth.
So shall it be.
The Journeymaker walks out
Rotten marsh, swollen marsh,
widow marsh, willow marsh,
whose truths are bloated toads,
whose lies are shadow roads:
I ask the rain to clear my path,
I ask the wind to show my path,
breath by breath to lead me out,
star by star to burn the doubt,
a blade of fire to cleanse and smooth,
a blade of night to shape and soothe,
a blade of blue to make a song,
a blade of song to heal this wrong,
a lantern swaying over pools of water frozen with my breath,
a stitching of fine spidersilk,
these mountains, drawing pain away from field and meadow,
a blade of brass to bring my lover.
The Journeymaker finds shelter with Biruté
Come in, come out of the rain, Sister,
I ask the water-curtains to part,
move the limbs of the willows,
let all the wet green welcome you
into my house of bleached logs and of wise moss.
You, riverwoman, brown muck woman,
guarded by otter and heron and white frog
in your house that sings the river—
will you ask of me for ornaments or weavings,
embroideries of starbound silver,
strands of my hair or other protections?
I am weary.
My feet blunder with this weariness,
my hands are weighed down with the unbraiding of hair,
my heart with the unbraiding of trust.
I ask for nothing, Sister, Journeymaker,
for aren’t you the one who brews shark-fin and bladegrass,
nurtures the wounded, be they birds or mortals,
in your high cave in the crags?
I do not like to speak of it.
You, who contains
the echo in its conch,
the Sword of War in its scabbard,
the tales of your kindness in refusal of speech;
you, who walks from city to city
clothed in obsidian and sunfire well-concealed in wraps:
who quilts lands,
who leads girls and women away from hurt,
who speaks with sisterbrothers, guides riverchildren to safe roads:
Sister, Journeymaker, you are forever welcome here,
where the river overflows
with meltwater, with spring green, with brown muck,
with the bubbling sweetness of summer,
and firebright blessings of fallen leaves,
where, in the arms of frost,
it flows to a stillness—
The river flows
from the heart of the marsh, through the forest, through all worlds.
You are forever welcome here.
I will enter then, Biruté,
to sit on these fallen-log benches,
take repast from your hands—grain and wild garlic,
fish soup and honeyed tea. I will allow
your helpers to touch me—
the beaver at my feet,
the otter at my elbow,
the white frog in my palm.
You are troubled.
It is so.
Would you speak of your trouble
into the breathing sap of the logs,
into water’s abundance,
You, mud-woman with eyes of amber,
dressed in green vines and shod in warbling clay:
I’ll speak as you ask, Biruté,
spit my failures,
spill my pain.
I sang to leave the marsh, yet I am here,
I sang to bring my lover, but he tarries;
and this I heard—to Long Shadow’s
thieving there can be no end.
The heart of the marsh is everchanging,
shifting, growing with heron-song and meltwater,
with the turtle’s turning and the swelling of the leech.
Yet nothing changes: these logs
that grew and fell once, and were polished to a smoothness
by the hands of the river: they have been here forever
neverliving, neversmoothed: forever—
and so this house, and so have I.
I’ll give you a truth
that leaps fishlike and is plucked
with the patience of herons:
Long Shadow comes here.
The child sits where you sit,
sips the fish stew from the same clay dish, and the children
that Long Shadow stole—they shine
from the folds of the garments.
I’d wish to say
that I wouldn’t let harm come to this child,
but I have let it go,
like you have released your lover:
To return, or yet not to return,
to make choices, to bleed, to hunger—
To carry the marsh inside,
the foreverness of it,
to raise one’s hands with river’s undulation—
to call oneself home, if one so wishes—
to call oneself home, if one so wishes,
to call oneself to speak to you.
I will bide then, if you will.
Yes—I would bid you to bide,
where the river flows
in the green of the sprouting of my heart,
in the fish-wells of my veins,
in the shadows of the folds of my shadows.
Enter Long Shadow
a garment of molddream and ash blended into tea
sheltering all those others—and for your companions
will it speak to me—is it capable of speech?moonbeam candy
does rot and diamondshine speak?sweet birch syrup
I’d knowmarbles of petrified dew to play with
of your pain, Long Shadow,
and how to assuage it.
/// turn me into a forgetting [of your offerings we would take]
swish away pain [ash poultice and burnt root of dandelion]
undo the past, undo us [to drink our selves from swamp and swell]
is that a bargain? do you speak
to me—are you capable of speech
or are you just repeating others:
drown its bogblood in water,
bury Long Shadow back in deep trenches
and not anymore pain [with gratitude, mother]
rainbows will rein in wood and field
and never another war—never another orphan
torn from its mother’s breast—never a pulled thread
in the stitchery of your peace. If only this pest
were no more—this orphan, this me, this us,
war-dredged animated stillborn sorrow ///
Such a world is not easily spun.
/// Not easily? How much would you erase?
How much uproot, unfabric, rip the tapestry off the land—
a wound here, a pestilence there,
this child with torn-out limbs, this blind
these gouged eyes, this crushed throat
this village screams forever,
this marsh conceals corpses—petrified logs
dead for millennia—
destroy the whole land while you’re at it! ///
your tale, that the land is fashioned from wars;
I stitched it myself, Long Shadow,
back when the world was young—
of dawn and dew and the joy of pitched tents,
of the braiding of my hair with thread and brass tokens,
of spiked goatmilk and the words sung
in my honor
under the harvesting of the stars
/// and I refuse
your tale, that the whole land was made
from sweets like moonbeam candy,
much less by you. There’d always been wars. Always
someone writhed in pain, and always
someone else called the battle beautiful,
adorned with blood-rubies bladesong and such nonsense
that makes children come to rot
unseen by the likes of you—
how would you now assuage our pain?
you say I stole these children: look again,
babes cut out from slain mothers,
or else refused life through knife and poison, and who would blame
our mothers? not even us ///
I need to think, Long Shadow,
of what you’ve told me here.
If wrongs cannot be rectified,
how can I help you then?
What good my presence?
/// Oh. You turn away.
Predictable, now that you know
we’re the children that nobody wants—
stolen from dead hands, discards
born maimed, imperfect, torn, too damaged for healing—
[of course she turns away]
but what would you say if I said
that some of us have been plucked
hale babes from loving parents
undamaged goods [will she turn away now?]
Will you turn away now? Or would you stay
to speak to us, or would it make no difference?
Immortals and mortals alike
recoil from maimed children. Easier not to see
the horrors inflicted upon us, easier to pretend
that nothing bad has happened here.
You cannot change unless you kill.
What need do I have of your changing? ///
I will think of your words and return.
/// I do not believe you.
[do you believe her?]
to what purpose?
I do not believe you
I do not believe you
I do not believe you ///
The Journeymaker walks out (II)
I shall stand on your steps, Biruté,
disdained by your toad and beaver, and the child.
How can you stand this—so many truths and none,
wrapped in mold and silver. No, I do not wish to run
from it, from them—but what can I do? If there’s nothing
to do, then why does the land cry out to me,
whisper in my ears to seek a healing?
The river flows. It flows
past pastures, past meadows of bluebell and periwinkle,
through the wild tangled thicket
where the wolf bears down the mother deer.
Her young will die—and their bones
grow through with wildflowers.
Listen, the river flows
beneath the everchanging moon
that casts a bitter shadow
into the waters. Have you seen the boats capsize,
and weddings end in drownings? Have you seen
nibbled by the fish, the weeds that grow
from those deaths, the waterlilies?
That, too, is the river.
You say ignore these ills,
for they are only natural?
Tell me, what does the river do?
and if it does not do, then what’s the point
of rivers? What is the purpose of the moon? The push and pull
of the tides, the incessant changing of it
that changes not at all?
I’m not here to flow, Biruté,
or to contend myself with inaction.
I protect this land with arm and sword,
I fight off those who would wreck it
with plough and battering ram—I protect
the land from worse ills, unspeakable ills,
from the ravening of plagues, and from people
who come from the stars
to break and kill and strip bare—I fight this.
I bring the dying to my cave
high in the crags, and while nobody watches
I sing the Sword of Healing over mortal wounds,
then let them go, and seek no gratitude. I stitch
paths through wars old and new, and I lead out
those who pray to me. My path is not the moon’s,
or the river’s, Biruté. If I cannot do,
if there’s no help that is asked, or even possible,
what is it that you want from me?
Cease of your words and attend.
Some wrongs cannot be rectified;
as the river flows,
some wrongs become life.
The Journeymaker stops the world
I lift my arms to the sky,
the shifting stars that ever walk with me—
that I’m to right the wrongs,
to hold the Sword of War safe in its scabbard,
the Sword of Song forever bare and poised to heal;
if that is meaningless, the world
will stop from breath, the rivers from flowing,
the mountains from slow growth, the trees from sap,
the wind from its birth,
the rainbow bridges from their shining,
the bounty of the rain from its harvest—the birds to freeze
mid-flight, and the land to stop from its tilting.
Here, in the forevernow
empty of breath and significance,
I draw again on the sword of bronze.
I come, Journeymaker,
though my work is not done,
I step over emptinesses that froze
between us, I move without motion
in this place that is no-place.
Beloved, let me braid your hair
with threads of sungold and with brass tokens.
I’ve forged new ones while I worked
on other tasks you’d set to me:
star and skylark,
raindrops and the wheeling of the sun.
Keddar, an oracle has told me
that your deeds have birthed the wars. Others said
that wars have been here forever,
the whole land marrow-made from them,
and no escape.
There’s never been an escape. Day and night I toil
to keep the land safe from harm—I rest
fitfully, I sleep alone
between the bare bones of the earth, I soar
with heaviness. Beloved, I am tired
of these accumulated lives, misdeeds,
of the hurts unhealed, unending
suffering of those I cannot touch, and those I can.
When will there be a forgetting?
I do not deny my crimes.
You would not let me if I wanted,
And I will never want. I led soldiers in battle
joyfully—I found gladness
in the vanquishing of my foes,
the ruination of cities.
In your service, I remember, and let
the remembering make me.
In your service, I work
to do differently.
I do not know if that will be enough.
Some wrongs can never be undone.
They could be quilted over.
Yes, you could, but you would know
what’s been mended and hidden
under the newly beautiful cloth.
That too will become soiled
and torn. It always does.
Why should I keep at my stitching?
Why not let
the whole tapestry go, unravel,
fall into dust between my fingers?
Why should the world keep its tilting?
Love, do you ask,
how to aid those who refused you,
and if they keep refusing you, then you will stop
the world, undo everything?
Do not call me that
if even you will turn against me.
I will never
turn against you—
never again. But these truths
call out for you. They whisper, they ask:
painful lives, or nothing? Mistakes
we seek in vain to amend, lives—
all the rugged breaths, living, surviving—
crooked, but surviving
to the tasks I have set you, between frozen stars
or a nothingness.
sow peace and reap it with a bloody scythe,
bring back severed threads and call them beautiful.
Return when you’re done,
if there’s a world to return to,
with the tokens you made for me,
to spin the ashes of my anger
into a gray thread for my hair.
As you command.
The Journeymaker comes to no conclusion
Across the winter grows the shadow long,
across the spring it ripens
to life, and then it comes to devastation.
In summer, the blue of broken eggs
whispers at me, the unborn birds
stolen by lynx and squirrel. That is not the wheel,
I say as the wheel turns. I separate
seasons from unseasons, and yet the pain
fills the bones of the world, until it has always been so.
I heal, they turn away. I walk alone,
I scream, let me do what’s required of me
to make these threads sing—but even the threads
that rotted resist their pulling. When I return
to seek Long Shadow—will I speak over
to hush their voice, or attend?
Before I can,
I’ll make for me a journey
through rock and wind,
sail the seawater—consider
what I have learned from this, while the world tilts,
and come to no conclusion.
Some wrongs cannot be rectified:
that in itself is a story. That in itself
is the world, much as I resist it: raveled threads
that grow wild from suffering, bloom
in memory’s long forgetting, that strive
with riotous colors—
Some wrongs become life.


text:
Gaming addiction’s status as an internationally-recognised disorder will be judged by the World Health Organisation this week.
Members of the WHO will sit at the World Health Assembly in Geneva, running from today until May 28th, to vote on the eleventh iteration of the International Classification of Diseases. This iteration (the ICD-11) infamously included adding “gaming disorder” to WHO’s Compendium of Diseases.
Should it be listed, gaming disorder would be diagnosed to individuals who exhibit impaired control over the frequency and duration of gaming sessions, at the expense of other interests and activities, and that continues or escalates even as health and relationships deteriorate.
Pushback from the games industry has, naturally, been strong. The ESA’s new president, Stanley Pierre-Louis, gave a little more ground to the WHO while still insisting further conversation is needed on the subjects of health and gaming.
"We believe that continued conversation and education is needed before any classification is finalised. In fact, leading mental health experts have cautioned repeatedly that classifying 'Gaming Disorder' creates a risk of misdiagnosis for patients who most need help," said Pierre-Louis.
"It's our hope that through continued dialogue we can help the WHO avoid rushed action and mistakes that could take years to correct.
"As an industry, we are committed to collaborating with stakeholders, researchers, policymakers, and parents to ensure best-in-class ratings, parental controls, and other tools help video game players and parents understand and manage healthy video game play."
The games industry may just be rightly worried about the economic impact of listing the disorder. South Korea, for example, could lose $6 billion in revenue from the stigma of assigning a disease to the medium.

domain: medical


text:
Oregon Red Maple Beauty
Photograph - Natural Photograph
During a very mild Autumn day in October while traveling through the beautiful city of Beaverton located in Oregon of the Pacific Northwest.. Beauty..
November 7th, 2012
Viewed 185 Times - Last Visitor from New York, NY on 04/16/2015 at 8:34 AM

domain: travel


text:
Four Man United young players were given the chance to train with the first team today.
Manchester United Football Club are preparing for what has become a massive game at home to Nottingham Forest. Erik ten Hag will feel the pressure mounting. Only a victory here will do.
Ahead of the game, the gaffer is using this opportunity to get a closer look at the next generation. The usually reliable Steven Railston took to Twitter to state that four United starlets trained with the senior squad today. Hence, their absence against Stockport last night.
All of Hannibal Mejbri, Isak Hansen-Aaroen, Omari Forson and Marc Jurado were absent as the U21s won on penalties yesterday evening. Now, they’re all set to be given the chance to impress the gaffer in a session with the senior squad.
Check out Steven Railston’s tweet here:
This is a massive opportunity for all of them. Whether they take that chance is up to the four players individually. Ten Hag’s made a point to show that you’ll have to force your way into the mix, rather than be handed minutes at the highest level. That’s exactly the way it should be.
These players all have the skill and ability to do exactly that. I’d imagine Hannibal is the closest to making the leap. He had a good pre-season and was heavily involved.
In terms of raw talent and ability, though, I love Hansen-Aaroen. The young attacking midfielder is a stunning footballer who is perfect for this system. He looked far too good for youth level and I do believe he’s ready to make that next step. A loan would probably suit.
Marc Jurado and Omari Forson may find it pretty tough. At least in the short term. Both have work to do still, while rising up the pecking order may be tough due to the sheer amount of bodies in front of them…
Do you think any of the four are good enough to make it at Man United? Let us know your thoughts in the comment box below.


text:
- This event has passed.
Historia Live! Louise Hare, Liz Fremantle and Vaseem Khan
September 21, 2023 @ 7:00 pm - 10:00 pm£5.00
Historia Live! Come to the Wheatsheaf in Fitzrovia to enjoy a free ranging conversation with three brilliant historical novelists, chaired by author and writing tutor Emma Darwin.
Enjoy the talk – which will last for about an hour – then stay to buy copies of their books (you know you want to) and enjoy a drink with them all, as well as other authors and enthusiasts of historical writing.
Doors open at 7 and the conversation will begin at 7.30!

domain: literature


text:
Atlanta band kicks-off debut album with brewery tour
Just months following the release of their self-titled, debut album, Atlanta band Sabbatical Year is embarking on a tour that will land them in breweries across the country.
The Drunken Funk Brewery Tour currently has stops in Tennessee, New York and in Athens 5:30-7:30 p.m. Saturday at Terrapin Beer Co. and Brewery.
Nick Margiasso, lead vocalist, recently sat down with Athens Banner-Herald for a Q&A session about the new album and current tour.
ABH: If you had to describe your sound to people, how would you do that?
NM: It's hard to do ... But, it's actually one of the great things about the band, that we are slightly hard to describe. The piano, as a main focal point, tethers us into music like Coldplay, Ben Folds Five, Elton John. We probably each represent one of those influences. We don't all agree that we like them all, that's one of the funny things about our band. We actually don't share a similar taste in music, which is crazy. I think it makes us realize how special it is.
ABH: Are you working on new stuff or just touring right now?
NM: We are almost finished writing the new album and we hope to start recording next month. Things started to heat up for us really quick, so we hope to let this album steep a bit longer.
ABH: I know you write all your own lyrics and music. Is that something that's important to you?
NM: I would never, ever in a million years have somebody else write my music. I consider myself a writer. When I get to writing lyrics, I realized sometimes you are made to write a certain way, I feel like music is that way. Me and Drew (Norris, keys and guitar) also have this amazing chemistry when it comes to writing. He doesn't write lyrics, but I do and I don't write music, but he does. So, it's almost like we are the blind leading the blind. But, that also makes you fill in the gaps creatively in a way that maybe you wouldn't have thought of before.
ABH: Do you think you'll stick with breweries from here on out?
NM: Until the next album, that's going to be our main focus. We're hoping to at least double our fan base with it. The most confident we are is going out and playing live and Athens is the perfect place to do that.
Follow breaking news reporter Allie Jackson at www.facebook.com/AllieJacksonABH or www.twitter.com/Allie_ABH.


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Castletroy’s Chloe Ryan was the hero as Ireland’s Women sneaked a one-point win against hosts Scotland on the opening day of the Home Internationals at Downfield Golf Club.
Ryan’s 1UP win over Louise Duncan in their singles match proved the crucial point in a ding-dong battle between the two sides that Ireland eventually came out on top of, 5-4.
Lurgan’s Annabel Wilson and Clandeboye’s Jessica Ross put Ireland’s first point on the board with a 3&2 win in game one but Ireland’s backs were against the wall when they went down in the next three matches.
Ireland needed some inspiration in the singles and it came in the shape of Ross who destroyed Hannah Darling 6&5 before Castlewarden’s Lauren Walsh got the women in green right back in the match with a 4&3 win over Penny Brown.
On debut, Cork’s Rachel Thompson was unable to add another point for Ireland but when Lisburn’s Paula Grant, out in the last game, got her match done early with a 3&2 win, it left the tie hinging on Ryan who duly delivered to upset the home side and give Ireland the perfect start on which to build.
Meanwhile, in the other match-up, signs were ominous as England’s women destroyed Wales 8-1.
There was double joy for Ireland as the Girls in green also overcame the hosts in their respective encounter.
In another strong singles performance, Elm Park’s Anna Foster (6&5), Douglas’ Sara Byrne (2&1), Tramore’s Anna Dawson (2&1) and Lahinch’s Aine Donegan (6&4) all secured big victories to help Ireland to a comfortable 6-3 win.
In the other match, England also secured a straightforward 6-3 win over Wales.
To keep up with our players in green, click HERE for Women’s scoring and HERE for Girls action.
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text:
Sodium arsenite-induced abnormalities in expressions of Caveolin-1, eNOS, IKKβ, and COX-2 in SV-40 immortalized human uroepithelial cells and in urothelial carcinomas
Authors: Liu, X-P; Huang, Y-C; Hung, W-C; Chen, W-T; Yu, H-S; Chai, C-Y
Toxicology In Vitro.
HERO ID: 1255519
Arsenic, a known human carcinogen, is found throughout the crust of the earth. Prolonged arsenic exposure . . .
Arsenic, a known human carcinogen, is found throughout the crust of the earth. Prolonged arsenic exposure is a known cause of urothelial carcinoma (UC) and blackfoot disease (BFD). The aim of this study was to determine the effect of sodium arsenite on Caveolin-1 and downstream signaling molecules (eNOS, IKKβ and COX-2) expression in human urothelial cells (SV-HUC-1). Immunohistochemical (IHC) staining of Caveolin-1, eNOS, IKKβ, and COX-2 was also compared between UC patients from endemic and non-endemic areas of BFD in Taiwan. Immunocytochemical staining and Western blotting results revealed increased expression of Caveolin-1, IKKβ, and COX-2 but decreased eNOS in SV-HUC-1 cells treated with low concentration of arsenite. Additionally, MEK inhibitor (U0126) significantly attenuated arsenite-induced expression of Caveolin-1, IKKβ and COX-2 while reducing eNOS expression. The IHC staining of UCs revealed that expressions of Caveolin-1, IKKβ, and COX-2 were significantly higher in patients from endemic areas of BFD compared to patients from non-endemic areas (p=0.011, p=0.002, p=0.0001) whereas eNOS was significantly lower (p=0.0001). The correlation observed between Caveolin-1 and downstream signaling molecule expression may be an important mechanism of arsenic-induced urothelial carcinogenesis.

domain: biology


text:
"We Treat More Than Just Athletes."
As a sports-minded Chiropractor, Dr. Hagen is qualified to provide you with the most advanced care for your chiropractic needs. Families and athletes alike receive industry leading treatment for their concerns.
We are committed to providing you with the best experience possible. Whether you are a desk worker looking for corrective care, a landscaper who suffers from chronic pains, or an athlete seeking to improve performance, our comprehensive treatment will have you covered. Using evidence-based chiropractic treatments, we provide a program tailored to meet your individual needs. We will correct the issue and customize a support plan to ensure you maintain optimal health throughout the year.
Our mission at Rochester Sports Chiropractic is to offer the best musculoskeletal care available. Our primary treatment goals are to provide long lasting pain relief while improving overall function, performance and health.
10 Assembly Drive #105
Mendon, New York 14506
By appointment only
Some insurances are accepted, no referral necessary*
Blue Cross Blue Shield (Excellus)
HSA / FSA
*For most insurances
Who We Treat
Everyone would benefit from seeing a sports minded chiropractor. Not just athletes.
Dr. Hagen treated primarily at the Rochester Health Center in Henrietta, New York, but had rotations at Monroe Community Hospital. He has experience with many different populations and their limitations.
Dr. Hagen was assigned to treat at the Bath VA Medical Center during his clinical year.
Dr. Hagen has treated patients of all ages, some in their late 90's. The treatment is tailored to the individual for excellent results. The office is currently accepting Medicare.
Titleist Performance Institute Chiropractor
Dr. Hagen is the only Titleist Performance Institute (TPI) Medical 2 chiropractor in the region.
"Titleist Performance Institute (TPI) Certified Trainers are experts in identifying where faulty movement patterns and imbalances are impeding your performance. A stronger body. A stronger swing. A better score. " -Sports Medicine Clinic, Toronto ON.
Dr. Hagen has treated patients as young as 7-weeks old. Treatment for a pediatric patient is very safe and effective. The entire treatment is explained and demonstrated to the guardian before performed.
Dr. Hagen works with all types of athletes, and has extensive experience with:
Individualized Treatment Plan
Each patient will receive a customized treatment plan that focuses on myofascial release coupled with joint mobilization of their area of complaint.
Here are just a few of the treatments we may provide:
Active Muscle Release
Chiropractic wellness care
Core strengthening exercises
Instrument Assisted Techniques
Taping (RockTape, KT Tape, SpiderTech, etc..)
"Experts estimate that 90 percent of all world-class athletes use chiropractic care to prevent injuries and increase their performance potential. All National Football League (NFL) teams rely on DCs in varying capacities, and 77 percent of athletic trainers have referred players to a chiropractor for evaluation or treatment." -ACA
Active muscle release is used to allow for free and unimpeded movement of muscles, tendons, nerves and joints, to allow for a dramatic change in comfort, flexibility and strength. For elite athletes, it is used to "dial in" to the athlete’s injury to improve their form and function. This form of treatment generally provides long lasting results, meaning less treatments.
What to Expect
The mission of RSC Mendon is to provide better overall health to the community, while improving the population’s understanding of health and Wellness
The initial visit will include:
Please arrive a few minutes early to complete the necessary paperwork. If you have any outside x-rays, MRI, CT.. please bring the films and the report, if possible, to the first appointment. We do not take films in the office.
A thorough health history
A physical exam of the area of complaint
A problem focused treatment.*
After, home stretches and/or exercises will be provided to assist in treating any lingering issues. Understanding that everyone is different, everyone receives an individualized plan. Our ultimate goal is to get our patients back into good health as efficiently as possible.
The follow up visit will include:
Our office does not provide a "care-plan" but we do encourage routine check ups to keep the flair ups controlled.
Most patients will experience positive change after 1-3 visits and will be able to dictate if they want to continue with care. Our goal is to limit the amount of time spent in our office and let the patient take control of their recovery, under our guidance.
A problem focused history since last treatment
A physical exam of the area of complaint
A problem focused treatment*


Right now, my boyfriend and I live on an acre and we're currently establishing phase one of our first permaculture project. We are in the market for an expansion, however, and are looking to purchase land in the Blue Ridge area of Georgia. The scale we're considering is 10-15 acres. Eventually, I'd like to have the ability to grow a very small community on the land and establish a public community center, if we so choose.
So here's my question. Pasture is much more expensive than raw forest land. But, that's obviously because clearing pasture is difficult and expensive. Considering my long-term goals, how important is having pasture and how difficult, really, is it to clear yourself? What are the things we should consider when deciding on a ratio of pasture to raw land in a potential purchase? Additionally, what types of water resources should we look for and be wary of (in addition to a flood plain consideration)?
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A patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case report
Journal of Medical Case Reports volume 16, Article number: 247 (2022)
Irritable bowel syndrome is a functional gastrointestinal disease. Visceral hypersensitivity is the most important pathophysiology in irritable bowel syndrome. Currently, diagnosis of irritable bowel syndrome is based on symptoms and exclusion of other organic diseases. Although the diagnosis of irritable bowel syndrome can be made based on the Rome IV criteria, one may speculate that complete exclusion of other organic diseases is not so easy, especially in cases uncontrolled with standard therapies.
We present herein a case of familial Mediterranean fever in a young Japanese patient who had been suffering from an irritable bowel syndrome-like clinical course. A 25-year-old Japanese male had been diagnosed as having diarrhea-predominant irritable bowel syndrome 5 years earlier. Unfortunately, standard therapies failed to improve irritable bowel syndrome symptoms. After careful medical history-taking, we understood that he had also experienced periodic fever since 10 years ago. Although no mutation was identified in the Mediterranean fever gene, not only periodic fever but abdominal symptoms improved completely after colchicine administration. He was therefore diagnosed as having familial Mediterranean fever and that the abdominal symptoms may be related to the disease.
Familial Mediterranean fever should be considered as a cause of irritable bowel syndrome-like symptoms.
Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence [1, 2]. Clinical symptoms of IBS include abdominal pain and stool irregularities, as well as other somatic, visceral, and psychiatric comorbidities [1, 2]. Currently, diagnosis of IBS is based on symptoms and exclusion of other organic diseases. Although a diagnosis of IBS can be made based on the Rome IV criteria , one may speculate whether complete exclusion of other organic diseases is not so easy, especially in cases uncontrolled with standard therapies.
Familial Mediterranean fever (FMF) is a genetic autoinflammatory disease characterized by recurrent fever with serosal inflammation . FMF is considered to be rare in Japan, and the clinical features in Japanese tend to be milder than those observed in the Mediterranean population due to different genotypes of the Mediterranean fever (MEFV) gene [4, 5]. We present herein a case of FMF in a young Japanese patient who had been suffering from an IBS-like clinical course such as chronic severe diarrhea and abdominal pain. In clinical practice, we have experienced patients with an unknown cause of chronic diarrhea. When organic diseases are excluded by clinical tests or images including gastrointestinal endoscopy in patients with chronic diarrhea, we used to make a diagnosis of functional gastrointestinal diseases such as IBS. Based on the present case, we should consider FMF in the differential diagnosis of such patients with chronic diarrhea of unknown cause.
A 25-year-old Japanese male complained of uncontrollable watery diarrhea over 10 times a day and abdominal pain since 5 years ago. Abdominal pain was mild lower abdominal pain relieving after defecation. There was no convincing aggravating factor for the abdominal pain. He had never had any health problems in the past. There was no particular social, environmental, or family history. His occupation was civil servant. He had never smoked and had drunk socially. Medical examination at the first visit revealed blood pressure of 120/72 mmHg, pulse rate, of 72 times/minutes (regular), and body temperature of 36.2 °C. There were no obvious abdominal and neurological findings, including abdominal tenderness.
He had received esophagogastroduodenoscopy, colonoscopy, and capsule endoscopy in addition to urine and blood examinations, and abdominal imaging such as abdominal computed tomography and magnetic resonance imaging (MRI). However, no abnormal findings had been detected, and he was diagnosed with diarrhea-dominant irritable bowel syndrome (D-IBS) based on the Rome IV criteria. He then received oral medicines including loperamide (1.0 mg/day) for 1 month, albumin tannate (3.0 g/day) for 1 month, or ramosetron hydrochloride (5 μg/day) for 1 month without improvement of his abdominal symptoms prior to his first visit to our department.
He had been introduced to our department because of uncontrollable D-IBS for a long time. Laboratory testing including TSH was normal (Table 1). Whole-body computed tomography reveled no abnormality (Fig. 1A, B). To rule out collagenous colitis, infectious diseases, and celiac disease, colonoscopy including terminal ileum, random biopsies, and culture test of intestinal juice were performed and no macroscopic, pathological abnormality such as collagen band or possible disease-causing bacteria was observed (Fig. 1C, D). After careful medical history-taking, we understood that he had been experienced periodic fever since 10 years ago. Fever is characterized by recurrent (approximately once a month) and self-limited (a couple of days) fever. Figure 2 shows the time course of clinical characteristics. Blood examination on the day of fever revealed high white blood cell (WBC) count (20,400/μL), C-reactive protein (CRP) (1.79 mg/dL), and amyloid A protein (169 mg/dL) without anemia. However, during the interval between febrile attacks, his body temperature was normal and the laboratory data of inflammatory reaction were at normal levels. These clinical characteristics suggested a suspicion of familial Mediterranean fever (FMF), although we did not confirm that diarrhea and abdominal pain were associated with FMF. After 12 months since the start of colchicine administration at 0.5 mg/day, the patient has been free of fever. As shown in Fig. 2, not only periodic fever but also abdominal symptoms such as severe diarrhea improved completely after colchicine administration. All exons of the MEFV gene in the patient were sequenced, and no mutation was identified. Based on these findings, we concluded a diagnosis of FMF according to the criteria in Japan  in spite of the lack of gene mutation, and that abdominal symptoms may be related to the disease.
To our knowledge, there are no reports on the relationship between chronic diarrhea and FMF. The present case suggests that FMF should be considered to be a cause of chronic diarrhea, especially when organic gastrointestinal diseases are excluded.
FMF is characterized by self-limiting fever episodes, usually accompanied by serositis, arthralgia, and arthritis . The diagnosis of FMF is made based on patient history, inflammatory markers, and genetic testing . Several clinical diagnostic criteria sets have been proposed for diagnosis of FMF. The Tel Hashomer criteria, Livneh criteria, and Turkish pediatric criteria all rely on clinical symptoms, family history, and colchicine response [7,8,9]. In the diagnosis of Japanese patients with FMF, modified Tel Hashmer criteria (Fig. 3) have been suggested . These include: recurrent febrile episodes (three or more episodes lasting 12 h to 3 days with fever ≥ 38 °C), and eight minor criteria as shown in Fig. 3. A diagnosis of FMF is determined if the patient exhibits the major criteria and one or more minor criteria. Differential diagnoses include infections, malignancy, and autoinflammatory diseases. In the present case, we diagnosed FMF because of recurrent febrile episodes and a favorable response to colchicine.
With regard to treatment for FMF, there are limited RCTs assessing interventions for patients with FMF in the most recent Cochrane Database . Based on the evidence, daily colchicine may reduce the number of attacks. It has also been described that canakinumab probably reduces the number of attacks, and anakinra or canakinumab probably reduce CRP in colchicine-resistant participants. Thus, further research should be carried out to establish standard therapy for FMF.
With regard to a relationship between FMF and gastrointestinal disorders, accumulating evidence has suggested that some FMF patients exhibit intestinal mucosal lesions resembling inflammatory bowel diseases (IBD) [11, 12]. Uslu et al.  demonstrated that disease-causing MEFV mutations and the FMF disease rate were increased among patients with IBD. This increase was prominent among CD patients. Thus, FMF is considered to be a possible cause in patients with chronic intestinal mucosal lesions. However, in the present case, upper and lower gastrointestinal endoscopy detected no mucosal lesions in the gastrointestinal tract. These findings suggested that chronic diarrhea and abdominal pain came from functional but not organic gastrointestinal diseases such as IBD. Ekinci et al. examined a relationship between FMF and functional gastrointestinal disorders . In their report on Turkish people, D-IBS was observed in 3 out of 103 FMF patients (2.9 %) and 2 out of 100 healthy subjects (2 %), respectively, suggesting that coexistence of FMF and D-IBS was not high in FMF when compared with healthy control. In other words, we suggest that D-IBS was observed incidentally in patients with FMF. In the present case, D-IBS developed from FMF rather than other causes incidentally because colchicine completely prevented not only typical FMF-induced febrile attacks but also severe diarrhea and abdominal pain.
The present case demonstrates that FMF can present IBS-like symptoms without intestinal mucosal lesions. In clinical practice, we do not usually rule in/out FMF when IBS is considered to be a highly possible diagnosis in patients with diarrhea and abdominal pain without any organic abnormality. FMF can be diagnosed even if mutation of MEFV gene is not detected. In Japan, MEFV gene mutation is not detected in approximately 5% of patients with FMF . The present case suggests that patients with FMF may manifest gastrointestinal disease mimicking IBS, because colchicine potently improved not only periodic fever but also gastrointestinal symptoms such as diarrhea and abdominal pain.
FMF should be considered as a cause of IBS-like symptoms, especially in patients diagnosed with IBS who do not respond to conventional IBS treatment.
Availability of data and materials
Data relevant to this case report are not available for public access because of patient privacy concerns but are available from the corresponding author on reasonable request.
Irritable bowel syndrome
Familial Mediterranean fever
Diarrhea-dominant irritable bowel syndrome
Inflammatory bowel diseases
Enck P, Aziz Q, Barbara G, et al. Irritable bowel syndrome. Nat Rev Dis Primers. 2016;2:16014.
Fukudo S, Okumura T, Inamori M, et al. Evidence-based clinical practice guidelines for irritable bowel syndrome 2020. J Gastroenterol. 2021;56:193–217.
Özen S, Batu ED, Demir S. Familial Mediterranean fever: recent developments in pathogenesis and new recommendations for management. Front Immunol. 2017;8:253.
Migita K, Asano T, Sato S, et al. Familial Mediterranean fever: overview of pathogenesis, clinical features and management. Immunol Med. 2018;41:55–61.
Kishida D, Nakamura A, Yazaki M, et al. Genotype-phenotype correlation in Japanese patients with familial Mediterranean fever: differences in genotype and clinical features between Japanese and Mediterranean populations. Arthritis Res Ther. 2014;16:439.
Sönmez HE, Batu ED, Özen S. Familial Mediterranean fever: current perspectives. J Inflamm Res. 2016;9:13–20.
Livneh A, Langevitz P, Zemer D, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 1997;40:1879–85.
Yalcinkaya F, Ozen S, Ozcakar ZB, et al. A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology. 2009;48:95–398.
Ozen S, Demirkaya E, Erer B, et al. EULAR recommendations for the management of familial Mediterranean fever. Ann Rheum Dis. 2016;75:644–51.
Yin X, Tian F, Wu B, Xu T. Interventions for reducing inflammation in familial Mediterranean fever. Cochrane Database Syst Rev. 2022;3:CD010893.
Beşer OF, Kasapçopur O, Cokuğraş FC, et al. Association of inflammatory bowel disease with familial Mediterranean fever in Turkish children. J Pediatr Gastroenterol Nut. 2013;56:498–502.
Saito D, Hibi N, Ozaki R, et al. MEFV gene-related enterocolitis account for some cases diagnosed as inflammatory bowel disease unclassified. Digestion. 2020;101:785–93.
Uslu N, Yüce A, Demir H, et al. The association of inflammatory bowel disease and Mediterranean fever gene (MEFV) mutations in Turkish children. Dig Dis Sci. 2010;55:3488–94.
Ekinci RMK, Balcı S, Akay E, et al. Frequency of functional gastrointestinal disorders in children with familial Mediterranean fever. Clin Rheumatol. 2019;38:921–6.
Migita K, Izumi Y, Jiuchi Y, et al. Familial Mediterranean fever is no longer a rare disease in Japan. Arthritis Res Ther. 2016;18:175.
The authors thank Dr. Ohhira for English language editing.
The authors declare no competing financial interests.
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Kumei, S., Ishioh, M., Murakami, Y. et al. A patient with familial Mediterranean fever mimicking diarrhea-dominant irritable bowel syndrome who successfully responded to treatment with colchicine: a case report. J Med Case Reports 16, 247 (2022). https://doi.org/10.1186/s13256-022-03446-z


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Musical settings (art songs, Lieder, mélodies, (etc.), choral pieces, and other vocal works set to this text), listed by composer (not necessarily exhaustive)
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With growing concerns about the use of heroin in New Canaan, police are equipping themselves with a new tool to combat opioid overdoses.
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