text:
Key Specifications Table
|Species Reactivity||Key Applications||Host||Format||Antibody Type|
|H, R, M, Bat, Fe, Mk||IHC, IH(P), IP, WB||Rb||Serum||Polyclonal Antibody|
|Presentation||Rabbit polyclonal antisera, liquid, no preservatives.|
|Safety Information according to GHS|
|Material Size||50 µL|
Anti-Choline Acetyltransferase (ChAT) Antibody SDS
|Reference overview||Application||Species||Pub Med ID|
|Conditional targeting of medium spiny neurons in the striatal matrix.|
Reinius, B; Blunder, M; Brett, FM; Eriksson, A; Patra, K; Jonsson, J; Jazin, E; Kullander, K
Frontiers in behavioral neuroscience 9 71 2015
The striatum serves as the main input to the basal ganglia, and is key for the regulation of motor behaviors, compulsion, addiction, and various cognitive and emotional states. Its deterioration is associated with degenerative disorders such as Huntington's disease. Despite its apparent anatomical uniformity, it consists of intermingled cell populations, which have precluded straightforward anatomical sub-classifications adhering to functional dissections. Approximately 95% of the striatal neurons are inhibitory projection neurons termed medium spiny neurons (MSNs). They are commonly classified according to their expression of either dopamine receptor D1 or D2, which also determines their axonal projection patterns constituting the direct and indirect pathway in the basal ganglia. Immunohistochemical patterns have further indicated compartmentalization of the striatum to the striosomes and the surrounding matrix, which integrate MSNs of both the D1 and D2 type. Here, we present a transgenic mouse line, Gpr101-Cre, with Cre recombinase activity localized to matrix D1 and D2 MSNs. Using two Gpr101-Cre founder lines with different degrees of expression in the striatum, we conditionally deleted the vesicular inhibitory amino acid transporter (VIAAT), responsible for storage of GABA and glycine in synaptic vesicles. Partial ablation of VIAAT (in ~36% of MSNs) resulted in elevated locomotor activity compared to control mice, when provoked with the monoamine reuptake inhibitor cocaine. Near complete targeting of matrix MSNs led to profoundly changed motor behaviors, which increased in severity as the mice aged. Moreover, these mice had exaggerated muscle rigidity, retarded growth, increased rate of spontaneous deaths, and defective memory. Therefore, our data provide a link between dysfunctional GABA signaling of matrix MSNs to specific behavioral alterations, which are similar to the symptoms of Huntington's disease.
|Silencing of Cholinergic Basal Forebrain Neurons Using Archaerhodopsin Prolongs Slow-Wave Sleep in Mice.|
Shi, YF; Han, Y; Su, YT; Yang, JH; Yu, YQ
PloS one 10 e0130130 2015
The basal forebrain (BF) plays a crucial role in cortical activation. Our previous study showed that activation of cholinergic BF neurons alone is sufficient to suppress slow-wave sleep (SWS) and promote wakefulness and rapid-eye-movement (REM) sleep. However, the exact role of silencing cholinergic BF neurons in the sleep-wake cycle remains unclear. We inhibitied the cholinergic BF neurons genetically targeted with archaerhodopsin (Arch) with yellow light to clarify the role of cholinergic BF neurons in the sleep-wake cycle. Bilateral inactivation of cholinergic BF neurons genetically targeted with archaerhodopsin prolonged SWS and decreased the probability of awakening from SWS in mice. However, silencing these neurons changed neither the duration of wakefulness or REM sleep, nor the probability of transitions to other sleep-wake episodes from wakefulness or REM sleep. Furthermore, silencing these neurons for 6 h within the inactive or active period increased the duration of SWS at the expense of the duration of wakefulness, as well as increasing the number of prolonged SWS episodes (120-240 s). The lost wakefulness was compensated by a delayed increase of wakefulness, so the total duration of SWS and wakefulness during 24 h was kept stable. Our results indicate that the main effect of these neurons is to terminate SWS, whereas wakefulness or REM sleep may be determined by co-operation of the cholinergic BF neurons with other arousal-sleep control systems.
|Expression Profiles of Neuropeptides, Neurotransmitters, and Their Receptors in Human Keratocytes In Vitro and In Situ.|
Słoniecka, M; Le Roux, S; Boman, P; Byström, B; Zhou, Q; Danielson, P
PloS one 10 e0134157 2015
Keratocytes, the quiescent cells of the corneal stroma, play a crucial role in corneal wound healing. Neuropeptides and neurotransmitters are usually associated with neuronal signaling, but have recently been shown to be produced also by non-neuronal cells and to be involved in many cellular processes. The aim of this study was to assess the endogenous intracellular and secreted levels of the neuropeptides substance P (SP) and neurokinin A (NKA), and of the neurotransmitters acetylcholine (ACh), catecholamines (adrenaline, noradrenaline and dopamine), and glutamate, as well as the expression profiles of their receptors, in human primary keratocytes in vitro and in keratocytes of human corneal tissue sections in situ. Cultured keratocytes expressed genes encoding for SP and NKA, and for catecholamine and glutamate synthesizing enzymes, as well as genes for neuropeptide, adrenergic and ACh (muscarinic) receptors. Keratocytes in culture produced SP, NKA, catecholamines, ACh, and glutamate, and expressed neurokinin-1 and -2 receptors (NK-1R and NK-2R), dopamine receptor D2, muscarinic ACh receptors, and NDMAR1 glutamate receptor. Human corneal sections expressed SP, NKA, NK-1R, NK-2R, receptor D2, choline acetyl transferase (ChAT), M3, M4 and M5 muscarinic ACh receptors, glutamate, and NMDAR1, but not catecholamine synthesizing enzyme or the α1 and β2 adrenoreceptors, nor M1 receptor. In addition, expression profiles assumed significant differences between keratocytes from the peripheral cornea as compared to those from the central cornea, as well as differences between keratocytes cultured under various serum concentrations. In conclusion, human keratocytes express an array of neuropeptides and neurotransmitters. The cells furthermore express receptors for neuropeptides/neurotransmitters, which suggests that they are susceptible to stimulation by these substances in the cornea, whether of neuronal or non-neuronal origin. As it has been shown that neuropeptides/neurotransmitters are involved in cell proliferation, migration, and angiogenesis, it is possible that they play a role in corneal wound healing.
|Complete morphologies of basal forebrain cholinergic neurons in the mouse.|
Wu, H; Williams, J; Nathans, J
eLife 3 e02444 2014
The basal forebrain cholinergic system modulates neuronal excitability and vascular tone throughout the cerebral cortex and hippocampus. This system is severely affected in Alzheimer's disease (AD), and drug treatment to enhance cholinergic signaling is widely used as symptomatic therapy in AD. Defining the full morphologies of individual basal forebrain cholinergic neurons has, until now, been technically beyond reach due to their large axon arbor sizes. Using genetically-directed sparse labeling, we have characterized the complete morphologies of basal forebrain cholinergic neurons in the mouse. Individual arbors were observed to span multiple cortical columns, and to have greater than 1000 branch points and total axon lengths up to 50 cm. In an AD model, cholinergic axons were slowly lost and there was an accumulation of axon-derived material in discrete puncta. Calculations based on published morphometric data indicate that basal forebrain cholinergic neurons in humans have a mean axon length of ∼100 meters.DOI: http://dx.doi.org/10.7554/eLife.02444.001.
|The cholinergic basal forebrain in the ferret and its inputs to the auditory cortex.|
Bajo, VM; Leach, ND; Cordery, PM; Nodal, FR; King, AJ
The European journal of neuroscience 40 2922-40 2014
Cholinergic inputs to the auditory cortex can modulate sensory processing and regulate stimulus-specific plasticity according to the behavioural state of the subject. In order to understand how acetylcholine achieves this, it is essential to elucidate the circuitry by which cholinergic inputs influence the cortex. In this study, we described the distribution of cholinergic neurons in the basal forebrain and their inputs to the auditory cortex of the ferret, a species used increasingly in studies of auditory learning and plasticity. Cholinergic neurons in the basal forebrain, visualized by choline acetyltransferase and p75 neurotrophin receptor immunocytochemistry, were distributed through the medial septum, diagonal band of Broca, and nucleus basalis magnocellularis. Epipial tracer deposits and injections of the immunotoxin ME20.4-SAP (monoclonal antibody specific for the p75 neurotrophin receptor conjugated to saporin) in the auditory cortex showed that cholinergic inputs originate almost exclusively in the ipsilateral nucleus basalis. Moreover, tracer injections in the nucleus basalis revealed a pattern of labelled fibres and terminal fields that resembled acetylcholinesterase fibre staining in the auditory cortex, with the heaviest labelling in layers II/III and in the infragranular layers. Labelled fibres with small en-passant varicosities and simple terminal swellings were observed throughout all auditory cortical regions. The widespread distribution of cholinergic inputs from the nucleus basalis to both primary and higher level areas of the auditory cortex suggests that acetylcholine is likely to be involved in modulating many aspects of auditory processing.
|Hippocampal sclerosis in dementia, epilepsy, and ischemic injury: differential vulnerability of hippocampal subfields.|
Hatanpaa, KJ; Raisanen, JM; Herndon, E; Burns, DK; Foong, C; Habib, AA; White, CL
Journal of neuropathology and experimental neurology 73 136-42 2014
Severe neuronal loss in the hippocampus, that is, hippocampal sclerosis (HS), can be seen in 3 main clinical contexts: dementia (particularly frontotemporal lobar degeneration [FTLD]), temporal lobe epilepsy (TLE), and hippocampal ischemic injury (H-I). It has been suggested that shared pathogenetic mechanisms may underlie selective vulnerability of the hippocampal subfields such as the CA1 in these conditions. We determined the extent of neuronal loss in cases of HS-FTLD (n=14), HS-TLE (n=35), and H-I (n=20). Immunohistochemistry for zinc transporter 3 was used to help define the CA3/CA2 border in the routinely processed human autopsy tissue samples. The subiculum was involved in 57% of HS-FTLD, 10% of H-I, and 0% of HS-TLE cases (pless than 0.0001). The CA regions other than CA1 were involved in 57% of HS-TLE, 30% of H-I, and 0% of HS-FTLD cases (p=0.0003). The distal third of CA1 was involved in 79% of HS-FTLD, 35% of H-I, and 37% of HS-TLE cases (p=0.02). The distal third of CA1 was the only area involved in 29% of HS-FTLD, 3% of HS-TLE, and 0% of H-I cases (p=0.019). The proximal-middle CA1 was the only area affected in 50% of H-I, 29% of HS-TLE, and 0% of HS-FTLD cases (p=0.004). These findings support heterogeneity in the pathogenesis of HS.
|Cholinergic neurons excite cortically projecting basal forebrain GABAergic neurons.|
Yang, C; McKenna, JT; Zant, JC; Winston, S; Basheer, R; Brown, RE
The Journal of neuroscience : the official journal of the Society for Neuroscience 34 2832-44 2014
The basal forebrain (BF) plays an important role in the control of cortical activation and attention. Understanding the modulation of BF neuronal activity is a prerequisite to treat disorders of cortical activation involving BF dysfunction, such as Alzheimer's disease. Here we reveal the interaction between cholinergic neurons and cortically projecting BF GABAergic neurons using immunohistochemistry and whole-cell recordings in vitro. In GAD67-GFP knock-in mice, BF cholinergic (choline acetyltransferase-positive) neurons were intermingled with GABAergic (GFP(+)) neurons. Immunohistochemistry for the vesicular acetylcholine transporter showed that cholinergic fibers apposed putative cortically projecting GABAergic neurons containing parvalbumin (PV). In coronal BF slices from GAD67-GFP knock-in or PV-tdTomato mice, pharmacological activation of cholinergic receptors with bath application of carbachol increased the firing rate of large (greater than 20 μm diameter) BF GFP(+) and PV (tdTomato+) neurons, which exhibited the intrinsic membrane properties of cortically projecting neurons. The excitatory effect of carbachol was blocked by antagonists of M1 and M3 muscarinic receptors in two subpopulations of BF GABAergic neurons [large hyperpolarization-activated cation current (Ih) and small Ih, respectively]. Ion substitution experiments and reversal potential measurements suggested that the carbachol-induced inward current was mediated mainly by sodium-permeable cation channels. Carbachol also increased the frequency of spontaneous excitatory and inhibitory synaptic currents. Furthermore, optogenetic stimulation of cholinergic neurons/fibers caused a mecamylamine- and atropine-sensitive inward current in putative GABAergic neurons. Thus, cortically projecting, BF GABAergic/PV neurons are excited by neighboring BF and/or brainstem cholinergic neurons. Loss of cholinergic neurons in Alzheimer's disease may impair cortical activation, in part, through disfacilitation of BF cortically projecting GABAergic/PV neurons.
|Catalpol Induces Neuroprotection and Prevents Memory Dysfunction through the Cholinergic System and BDNF.|
Wan, D; Xue, L; Zhu, H; Luo, Y
Evidence-based complementary and alternative medicine : eCAM 2013 134852 2013
To investigate the role and mechanism of catalpol on neuroprotective effects and memory enhancing effects simultaneously, neuroprotective effects of catalpol were assessed by neurological deficits score, TTC staining, and cerebral blood flow detecting. Morris water maze was employed to investigate its effects on learning and memory and then clarify its possible mechanisms relating the central cholinergic system and BDNF. Edaravone and oxiracetam were used for positive control drugs based on its different action. Results showed that catalpol and edaravone significantly facilitated neurological function recovery, reduced infarction volume, and increased cerebral blood flow in stroke mice. Catalpol and oxiracetam decreased the escape latency significantly and increased the numbers of crossing platform obviously. The levels of ACh, ChAT, and BDNF in catalpol group were increased in a dose-dependent manner, and AChE declined with a U-shaped dose-response curve. Moreover, the levels of muscarinic AChR subtypes M1 and M2 in hippocampus were considerably raised by catalpol. These results demonstrated that catalpol may be useful for neuroprotection and memory enhancement, and the mechanism may be related to the central cholinergic system.
|An allosteric regulator of R7-RGS proteins influences light-evoked activity and glutamatergic waves in the inner retina.|
Cain, MD; Vo, BQ; Kolesnikov, AV; Kefalov, VJ; Culican, SM; Kerschensteiner, D; Blumer, KJ
PloS one 8 e82276 2013
In the outer retina, G protein-coupled receptor (GPCR) signaling mediates phototransduction and synaptic transmission between photoreceptors and ON bipolar cells. In contrast, the functions of modulatory GPCR signaling networks in the inner retina are less well understood. We addressed this question by determining the consequences of augmenting modulatory Gi/o signaling driven by endogenous transmitters. This was done by analyzing the effects of genetically ablating the R7 RGS-binding protein (R7BP), a membrane-targeting protein and positive allosteric modulator of R7-RGS (regulator of the G protein signaling 7) family that deactivates Gi/oα subunits. We found that R7BP is expressed highly in starburst amacrine cells and retinal ganglion cells (RGCs). As indicated by electroretinography and multielectrode array recordings of adult retina, ablation of R7BP preserved outer retina function, but altered the firing rate and latency of ON RGCs driven by rods and cones but not rods alone. In developing retina, R7BP ablation increased the burst duration of glutamatergic waves whereas cholinergic waves were unaffected. This effect on glutamatergic waves did not result in impaired segregation of RGC projections to eye-specific domains of the dorsal lateral geniculate nucleus. R7BP knockout mice exhibited normal spatial contrast sensitivity and visual acuity as assessed by optomotor reflexes. Taken together these findings indicate that R7BP-dependent regulation of R7-RGS proteins shapes specific aspects of light-evoked and spontaneous activity of RGCs in mature and developing retina.
|Neuroprotective effects of donepezil against cholinergic depletion.|
Cutuli, D; De Bartolo, P; Caporali, P; Tartaglione, AM; Oddi, D; D'Amato, FR; Nobili, A; D'Amelio, M; Petrosini, L
Alzheimer's research & therapy 5 50 2013
Intraparenchymal injections of the immunotoxin 192-IgG-saporin into medial septum and nucleus basalis magnocellularis causes a selective depletion of basal forebrain cholinergic neurons. Thus, it represents a valid model to mimic a key component of the cognitive deficits associated with aging and dementia. Here we administered donepezil, a potent acetylcholinesterase inhibitor developed for treating Alzheimer's disease, 15 days before 192-IgG-saporin injection, and thus we examined donepezil effects on neurodegeneration and cognitive deficits.Caspase-3 activity and cognitive performances of lesioned rats pre-treated with donepezil or saline were analyzed and compared to the outcomes obtained in pre-treated sham-lesioned rats.Cholinergic depletion increased hippocampal and neocortical caspase-3 activity and impaired working memory, spatial discrimination, social novelty preference, and ultrasonic vocalizations, without affecting anxiety levels and fear conditioning. In lesioned animals, donepezil pre-treatment reduced hippocampal and neocortical caspase-3 activity and improved working memory and spatial discrimination performances and partially rescued ultrasonic vocalizations, without preventing social novelty alterations.Present data indicate that donepezil pre-treatment exerts beneficial effects on behavioral deficits induced by cholinergic depletion, attenuating the concomitant hippocampal and neocortical neurodegeneration.

domain: biology


Union Railways Minister Piyush Goyal and state Chief Minister Devendra Fadnavis inaugurated the second phase of Mumbai monorail on Sunday.
The two ministers also travelled by the monorail till Wadala.
The project is around 19 kilometres long and around 30 lakh travellers are expected to travel through this line per month.
"The 8.26-km long Phase-I from Chembur to Wadala was already operational and now with this 11.28-km Phase-II from Wadala to Sant Gadge Maharaj Chowk having been completed, the Mumbaikars will be able to ride the entire 19.54-km long Chembur to Sant Gadge Maharaj Chowk Monorail corridor, which is devoid of any mass public rapid transit system," a statement from Mumbai Metropolitan Region Development Authority (MMRDA) read.
The entire project was scheduled to be completed in 2011 but after a delay of over eight years. The service will be available for the general public from Monday.
The Monorail will operate daily from 6 am to 10 pm with a 22-minute gap between the two Mono trains and will also reduce the travel time from 90 to a mere 30 minutes.
(This story has not been edited by Business Standard staff and is auto-generated from a syndicated feed.)


text:
This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database.
All Wales Medicines Strategy Group (AWMSG). Aripiprazole monohydrate (Abilify Maintena®) Penarth: All Wales Therapeutics and Toxicology Centre (AWTTC), secretariat of the All Wales Medicines Strategy Group (AWMSG). AWMSG Secretariat Assessment Report Advice No. 2214. 2014
Aripiprazole (Abilify Maintena®) 400 mg powder and solvent for prolonged released suspension for injection is recommended as an option for use within NHS Wales for the maintenance treatment of schizophrenia in adult patients stabilised with oral aripiprazole.
Subject indexing assigned by CRD
Delayed-Action Preparations; Humans; Injections; Piperazines; Quinolones; Schizophrenia
Country of organisation
An English language summary is available.
Address for correspondence
All Wales Therapeutics and Toxicology Centre, Academic Centre, University Hospital Llandough, Penlan Road, Penarth, Vale of Glamorgan CF64 2XX
Date abstract record published

domain: medical


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When I was young I had a very bad relationship with money. I was taught it was polite to refuse money when people tried to pay me, I believed that making money typically comes at someone else’s expense, that rich people can’t get into heaven, I had an “others first” type of mentality, along with other self-sabotaging, negative beliefs.
Let me tell you this now: all of that is total crap and it hurt me big time when I first started out in business.
At first I felt bad “taking” money from people. Stupid right? My really low prices reflected my sick beliefs about money.
Then, I woke up to reality.
I was talking to my very successful friend Dan about Dave Asprey, the guy behind Bulletproof Exec (a very interesting blog).
My friend was buying Dave’s Upgraded Protein powder, which I thought carried a very high price tag. I told my friend that you can get almost the exact same stuff in bulk for about half the price.
What Dan told me in response has stayed in my mind ever since:
“Cost doesn’t really matter to me at all. I’ll support companies trying to provide me with a quality product, even if it’s more. Profit is not a dirty word.”
Then I thought back on things that I buy which aren’t cheap. All of us spend money on some expensive products we *could* find cheaper substitutes for.
I like to spend lots of money on my hobbies – golf clubs and accessories, outdoor gear, firearms, AV stuff…
I also spend a lot of money on things that improve my health – my desk chairs, mattress, Vitamix blender, organic fruits and vegetables, naturally raised meat, kitchen equipment, etc.
A lot of other people spend a lot of money on their health as well. They want their health to be great and they don’t mind paying you for help.
Commerce isn’t a zero-sum proposition. When you buy stuff, you don’t LOSE money buying it, you GAIN the benefits of what you are exchanging your money for.
People don’t lose money when they pay you, they gain something very valuable – improved health through chiropractic care (especially when you are practicing high-value chiropractic).
If they felt that they were losing money by paying you, they wouldn’t pay you. They’d value their money over what you are providing.
Commerce is a win-win situation. People don’t buy stuff when they don’t see a net gain in the transaction.
If profit wasn’t a motive of people and companies, there would be fewer jobs and less wealth in the world.
It’s ok to make money. It’s good to make money. Your clients want to give you money. People who like you want to see you make money. When you make money you can take care of yourself, take care of your family and take care of others by helping more people through your business and giving to charities and causes you believe in.
So remember, profit isn’t a dirty word. You sell something that the late, great, Barry Anderson called “the greatest healthcare product in the world,” and while I really dislike the word “deserve,” you DESERVE to be paid the big bucks for the incredible value you offer your community.

domain: finance


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Millington Central High School Athletic Department is sponsoring a Coat Drive for new or gently used coats for the students of Millington from Nov. 18 – Dec. 18. (Pre-K through High School)
The National Active & Retired Federal Employees Association, Chapter 1382 meeting will be held Thursday, Dec. 10 at Ryan’s, 8165 Highway 51 North in Millington. Arrive by 11:30 a.m. to partake of the buffet; meeting will commence at noon. For more information, call Carolyn Cribbis at 413-7123.
Northridge Woodhaven Community Outreach will host the annual Light of Hope Community Candlelight Remembrance on Friday, Dec. 11 at 6 p.m. at Northridge Woodhaven Funeral Home, 6755 Highway 51 North, in Millington. This free community event is an opportunity for Mid-South residents to come together and honor their loved ones in a special way. Lighting candles for loved ones is interactive, impactful and visually beautiful, leaving everyone fulfilled. Joseph Brasher, Minister of Education at First Baptist Church-Millington, will be the guest speaker for this unique event, which will feature live music and refreshments. The Light of Hope Community Candlelight Remembrance is designed to promote comfort, hope and healing. Register your attendance by Nov.. 30 by contacting Lolita Poplar, Community Outreach Coordinator, at 872-3375 or via email at email@example.com.
Munford Baptist Church located at 1253 Munford Ave., presents Christmas Village 2015 on Saturday, from 6-8 p.m. The admission is free but no childcare is provided. The Christmas Village will include music, refreshments, and various village shops where children can create Christmas crafts and receive free giveaways. There will also be an indoor snow area and a visit from Mrs. Claus. For more information call, the church at 837-6325.
Temple United Methodist Church located at 4404 Sykes Road will be hosting a free soup lunchein from 11 a.m. to 1 p.m. at the church.
Friendship United Methodist Church presents the 2015 Youth Explosion “What are you doing with your dash?” The scripture is James 4:14 and the event will be Dec. 19 at the church located at 6220 Highway 51 North from noon to 3 p.m. Inviting the youth from Millington, Lucy, Woodstock, Northaven and Frayser. For more information, call Rodney McGhee 240-6082.

domain: news


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The house was born on Jim Cole’s birthday in 1998 when they decided to build a home that Cole would design himself. They found the ideal one-acre lot and pictured themselves drinking in the view from the great room. As the first to build in their area, they needed to site the house carefully, so Cole floated balloons at the corners of adjoining lots in order to visualize a worst-case scenario of nearby homes. A bit of a twist to the site plan, and the dwelling took shape.
Cole quickly turned his design into a floor plan and elevation, after which the Coles’ builder John Kaltenbach introduced him to designer Eric Spurlock. “He (Spurlock) embellished the design,” says Cole, “taking what I’d done but not making it his. I feel that I have pride of ownership.”
The home defies conventional architectural labeling. “There’s uniqueness in the architecture,” Cole says. “It’s compatible with Southwestern design, but we wanted to go somewhere else with it. It’s our style, eclectic but not crazy eclectic.” The distinguishing mark of the house is columns, lots of them, inside and out. There are mass, space, height, volume, and great sweeps of light. A very three-dimensional design. Cole thinks of the home in terms of cubic feet, seeing volume instead of square footage. From the entry foyer, the house radiates in every direction. Anasazi-style stone walls and tall columns bracket tantalizing glimpses of other, farther rooms. Rectangular works of art provided counterpoint to the curved walls, round ceiling and the sweep of the graceful staircase to the second floor. The floor is of stained concrete in a rich dark terra cotta. A handsome corbel motif seen throughout the house begins here, in the striking entry door of stained glass by Salvador Equihua. Another of his doors, appropriately decked out in grape clusters and leaves, leads to a charming below-staircase wine room.

domain: artistic


BEHIND-THE-SCENES ZOO STORIES
11-year-old Daniel Daperis takes us behind the scenes at three different zoos to see how animals are cared for and what zookeepers do.
Produced by ABC International, Inc.
Up-Res HD format by Chip Taylor Communications, LLC
3 x 22 minutes / URHD
1. Episode 1
2. Episode 2
3. Episode 3


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When it is the time to move on the other and new home, I think some of you will face this problem. The ugly arrangement with the old fashioned look. Something like this will never be able to represent your personality or making you comfortable to staying inside your home. When you find this situation, it means you have to be ready to make some renovation with the new arrangement. And, when you don’t know what to do because you have no idea about it, here I have prepared some new home decorating ideas in 2013. I hope it can help you arrange your renovation then.
The first thing that you can do is choosing what theme you want to use for your new home decorating ideas in 2013. This is very important because the other things you will do next must follow it. After it, you can choose the furniture color, pattern, and design. Of course the furniture you choose must be able to support the main theme you have chosen before. There are so many things you can’t apply in your home, for example is the minimalist design will never be suitable to be combined with the classical furniture, right? After that, you can pick the additional pattern in the wall to make it prettier.
The other pattern and details can you apply on your new modern home decorating ideas in 2013 are coming from the small stuff you put on the shelves. The colors and shape of those hings can bring the unique look too. Besides that, some cushions which rich of pattern and colors can also do the same for your space. The other details from the plant can also be used if you expect to get the freshness and refreshing green atmosphere too in your living room, bedroom, even the dinning room. The main point of all of them is be creative and brave to combine all of aspect you have inside them.


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Kale aphids are grey to green in colour with a waxy coat almost adapting the colour of kales. The waxy coat is key in differentiating the aphid from other pests. The pest forms a dense population on the leaf surface(colony).
The disease, caused by a fungus (Alternaria brassicae), can cause serious losses in kales.
This disease is caused by a bacterium (Pectobacterium carotovorum) which is left in the soil as a result of decaying dead plants.
Tomato blight is classified into two types: early tomato blight and late tomato blight. All of this is manageable through natural means.
Sweet potatoes weevils resemble an ant, has an antenna which is usually differentiated by the gender of the weevil, the females have club-shaped antennae while the males are straight.
It is therefore important for countries to relook into factor that have led to low productivity for instance land degradation and population pressure on land. These calls for more sustainable farming systems.

domain: agronomy


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Beginning a tree service on Long Island the perfect business for those looking to work for themselves with reduced overhead and a fairly small amount needed for initial investment. Whether you’re experienced or you’re trying to see what you need to do in order to prepare yourself for this venture, you’ll find everything you need to know about starting a tree service in Long Island. Let’s get to it.
Process servers are tasked provide legal documents to the legal proceeding’s named defendants or clients. This includes complaints, court summons, private lawsuits, subpoenas, and other related court transactions. They deliver documents while at the same time ensure that they comply with the federal and state laws and follow all process server rules. Sometimes, the job entails dealing with aggressive or hysterical recipients, so necessary caution should be observed. In a report released by Paysale.com in 2016, process servers receive an average yearly salary of around $36,308.
The shock of needing mold removal and realizing what the costs are sometimes hits Long Island homeowners like a brick wall. That is why we will be exploring where does mold usually hide and what can be done to prevent this from turning into an expensive home repair issue.
You must be bored because you found this blog. Well, hopefully I will be able to increase the level of boredom you posses when you read my posts.

domain: law


text:
Building and re-developing commercial real estate can be investments that yield excellent dividends. There are, however, often extensive legal considerations that come along with specific properties. Here are some legal factors about wetland permitting and mitigation banking that may influence how you approach investment in particular real estate.
What determines that the land in my project needs wetland mitigation?
The provisions of wetland mitigation banking are in Section 404 of the federal government’s Clean Water Act. The U.S. Army Corps of Engineers defines wetlands as satisfying three criteria. They must have:
- Wetland hydrology: Ground that is commonly saturated by water in the ground or on the surface.
- Wetland vegetation: Plants that optimally grow in wet conditions. Some may have aerenchyma, an attribute that allows plants like sedges to distribute oxygen from the atmosphere down to the root zone.
- Hydric soils: Soil that is anaerobic due to continued water saturation. The anaerobic soil is low in oxygen.
What is the role of wetland mitigation banking in wetland permitting?
Wetland mitigation banking is done to earn credits for wetland preservation, enhancement and restoration. These credits are recognized by regulatory agencies as offsetting the development impact on another piece of wetland in the same area. Committing to a wetland mitigation banking effort can expedite the permitting process on your development project.
How does a mitigation bank operate, and who can create one?
Developers and other investment parties involved in the purchase and development of property can create a mitigation bank. A mitigation bank can take some years to create and will need the legal establishment of a conservation easement. Once established, bank investors can use credits for their offsets, or sell them to other developers who need mitigation.
For many real estate investors and developers, participating in wetland mitigation banking is a win-win situation. Both the environment and economy benefit from well-placed improvement efforts.


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Water and Power Development Authority WAPDA jobs 2023
Water and Power Development Authority WAPDA has recently announced jobs vacancies for various management positions in Lahore, Chitral, Kohistan, Tarbela, and Karachi, located in the Punjab province of Pakistan. The advertisement for these vacancies was published in the Daily Nawaiwaqt newspaper on 23rd March 2023.
The available positions include Deputy Director, Director, Director Security, and Deputy Director Security. WAPDA is seeking qualified and experienced individuals who hold a bachelor’s degree or equivalent in the relevant field, and candidates with higher educational qualifications will be preferred.
The candidates applying for the management posts should have relevant experience in their respective fields. The job responsibilities and required qualifications for each position can be found in the advertisement.
Interested candidates can apply for the positions by sending their updated resumes and cover letters to the email address mentioned in the advertisement. The last date to apply for these positions is not mentioned in the advertisement, so interested candidates are encouraged to apply as soon as possible.
WAPDA offers a competitive salary package along with various benefits, including health insurance, provident fund, and other perks. The organization is committed to providing a safe and professional work environment that promotes employee growth and development.
In conclusion, if you are a qualified and experienced professional looking for management job opportunities in the Punjab region of Pakistan, then WAPDA jobs 2023 could be the perfect place for you to excel in your career.


Based upon recent polls, Hillary Clinton’s indictment is supported by the majority of Americans since they believe Clinton broke the law by allegedly sending and receiving top secret information through her private email server while working for the U.S. State Department. Bernie Sanders’ position on the emails scandal has also shifted slightly, with the Vermont senator now claiming the potential charges by the FBI are a “serious issue,” when previously he had completely dismissed the scandal as those “damn emails.”
Based upon previous statements from former House Majority Leader Tom Delay and Hosue Representative Darrell Issa, FBI Director James Comey wants Hillary Clinton indicted even “as we speak.” While Republicans may start salivating at the possibility, Comey is “being forced to triple-time make a case” due to the 2016 election and the general popularity of Clinton. Both men also seem to doubt the current Attorney General underneath President Obama will take action.
“I’ve worked with both the last attorney general … and this attorney general, and I really don’t believe they’ll do it,” Issa stated. “Doing it, by definition, would end her run for president. So do I think the Democrats are in an odd situation where the only thing they can do is hold their nose and hold back on an indictment? Sadly, yes.”
In addition, White House spokesman Josh Earnest said the Department of Justice (DOJ) is not moving ahead with Hillary Clinton’s indictment “based upon what we know.”
“What I know that some officials over there have said is that she is not a target of the investigation, so that does not seem to be the direction that it’s trending,” Earnest told White House reporters. “But I’m certainly not going to weigh in on a decision or in that process in any way. That is a decision to be made solely by independent prosecutors but again, based on what we know from the Department of Justice, it does not seem to be headed in that direction.”
RELATED REPORTS BY THE INQUISITR
According to Rasmussen Reports, the majority of Americans now think the DOJ should be moving in that direction. Based upon the recent polls, respondents say Hillary Clinton broke the law and should face the consequences of her actions, but Americans are “far less convinced that serious charges will be brought against her.” Rasmussen found that 64 percent of likely U.S. voters believe Hillary broke the law, with 47 percent saying it’s very likely. Only 29 percent believe it’s unlikely that Clinton broke U.S. laws, with nine percent saying it’s “not at all likely.” The polls also noted a marked increase in those who believe Clinton broke the law since the scandal first became popularized in 2015.
In the past, Bernie Sanders has refused to go on the attack against Clinton for the email server scandal. In fact, during a previous Democratic debate he stated he was “sick and tired of hearing about damn emails.” Now that the U.S. State Department has admitted that a minimum of 22 top secret emails were located on the email server, Sanders has not changed his position, but he did tell CNN’s Jake Tapper that he considers the issue to be serious.
“Nope, nope. That is not, I think, a fair assessment,” Sanders replied when asked by Tapper if Hillary had done wrong. “That is, I think, a very serious issue. There is a legal process taking place, I do not want to politicize that issue. It is not my style.”
Even if the FBI wants to push forward on Hillary Clinton’s indictment, it seems unlikely to happen based upon the current response by the Obama administration. Any criminal charges referred by the FBI will need to go through Assistant Attorney General Leslie Caldwell, Deputy Attorney General Sally Yates, Attorney General Loretta Lynch, and White House adviser Valerie Jarrett, all of whom are loyal Democrats. Tom DeLay says his FBI sources have already foreseen this scenario taking place, but “if the attorney general does not indict, they’re going public” right before America chooses the Democratic candidate for the 2016 elections.
Do you think the DOJ should have Hillary Clinton indicted? Should Bernie Sanders go on the attack instead of supporting Clinton on this issue?


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Houseplant Focus Repotting Mix 2 Litre
About this deal
Plants suitable for hanging may be depicted in a hanging grow pot, the actual grow pot used to ship the plant might not include these attachments. Check your planter will be tall enough to hide the grow pot if you are not re-potting directly into the planter. After entering your postcode, the updated charge will appear below the postcode if the amount is more than the minimum charge for that product type. Liners come in various sizes to fit the internal dimensions of the pot and can be trimmed down to size to create an unobtrusive barrier for the plant and soil to be potted into, whilst protecting the pot from unsightly calcium or fertiliser deposits from the soil.
Contains sterilised soil, coir, composted fine bark, wood fibre, as well as a carefully balanced range of nutrients to promote healthy growth for up to two months. This open, free draining mix promotes healthier growth and greener leaves for an outstanding indoor garden! Making our neighbourhoods a wonderful place is good for our wellbeing and more friendly to the environment. For plants in soil the key size in determining the maturity and fullness of a plant is the diameter of the grow pot. Houseplant Focus Repotting Mix is designed for best results with the widest range of houseplants (the pH is circa 6).
Growth Technology Houseplant Focus Repotting Mix is designed for the best results with the widest range of houseplants.
Located in Kentish Town, London, Boma garden centre is proud of its vision to transform the city into an urban paradise. Note: If the shape of the planter tapers strongly at the base, it might not be wide enough for your plant to sit squarely at the bottom.
Soil plants - The height of the grow pot can vary slightly, but is usually slightly smaller or the same as its diameter. INVERNESS HS1-8, IV41-49, IV51, IV55-56 ISLE, ISLE OF MAN IM1-9, IM99 ISLE, KILMARNOCK KA27-28 ISLE, OBAN PA20-33, PA35-38, PA49, PH36-39, PH49, PH50 ISLE, OBAN PA62-72, PA74-75, PA80, PA40-41 ISLE, OBAN PA34, PA41-48, PH42-44 ISLE, OBAN HS9, PA61, PA73, PA76-78 ISLE, OBAN PA60 ISLE, ORKNEY KW15-17 ISLE, SHETLAND ZE1-3 ISLE TRURO (Scilly Isles) TR21-25 ISLE.We choose to only sell the best performing products in the world, learning them inside and out to ensure your experience with our organisation and the products we supply are second to none. Note: Liners are "squashy" so they can be pushed through the opening to expand and fit closer to the pot wall once inside. We guarantee all of our floral products to last min 7 days (if less will be stated on the product description) 14 days for flowering plants and 1 month for green plants but with proper care and attention plants can be enjoyed for years to come. It includes a selection of sterilised soil, coir, composted fine bark, wood fibre, loam, vermiculite, maglime and nutrients. A free draining compost mix for your houseplants that contains coir, composted fine bark, wood fibre, sterilised soil and nutrients that promote growth for up to two months.

domain: hobby


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In 2001, with several million dollars from Nike, Salazar launched the Oregon Project, a challenge to the African hegemony in distance running. The program brought to Beaverton a handful of promising U.S. runners and gave them every legal advantage extant, from space-age training aids to the amenities of the Nike campus, which include a fitness center, testing labs, a two-mile wood-chip trail and the soft grass field on which Salazar would eventually collapse. But four years later the Oregon Project had produced only one moderately successful runner, Dan Browne, a 2004 U.S. Olympian in the 10,000 meters and the marathon. The lesson, Salazar says, is that "you can't take mediocre runners and expect them to achieve world-class results."Some might instead argue that you can't expect someone to be a great coach merely because he was a great athlete and has buckets of cash to throw around. After all, a certain Kiwi maintained that "champions are everywhere, all you have to do is train them properly". Now Salazar is working with Josh Rohatinsky and the Gouchers and getting pretty good results, but it's not like these runners didn't have things going well before Salazar started coaching them.
When the article turned towards religion--an important part of Salazar's life and his runners' as well--Salazar made an interesting statement. "[Rohatinsky] just does what he's told, completely on faith. Like a good Catholic, he believes that others are put in authority over you and you trust in them." Yet every good coach I've ever heard of actually stressed the exact opposite. Lydiard thought one of America's great downfalls in distance running was obedience to authority. "If your coach can't tell you why you are doing a particular workout, get yourself another coach", he said on many occaissions. And even if a coach can earn a position of absolute authority, Salazar hasn't come remotely close.
Discuss the article

domain: sports


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Temperature control is a process in which change of temperature of a space (and objects collectively there within) is measured or otherwise detected, and the passage of heat energy into or out of the space is adjusted to achieve a desired average temperature.
A home thermostat is an example of a closed control loop: It constantly assesses the current room temperature and controls a heater and/or air conditioner to increase or decrease the temperature according to user-defined setting(s). A simple (low-cost, cheap) thermostat merely switches the heater or air conditioner either on or off, and temporary overshoot and undershoot of the desired average temperature must be expected. A more expensive thermostat varies the amount of heat or cooling provided by the heater or cooler, depending on the difference between the required temperature (the "setpoint") and the actual temperature. This minimizes over/undershoot. This method is called Proportional control. Further enhancements using the accumulated error signal (Integral) and the rate at which the error is changing (Derivative) are used to form more complex PID Controllers which is the form usually seen in industry.
Pressure control (PC) is a mode of mechanical ventilation alone and a variable within other modes of mechanical ventilation. Pressure control is used to regulate pressures applied during mechanical ventilation. Air delivered into the patients lungs (breaths) are currently regulated by Volume Control or Pressure Control. In pressure controlled breaths a tidal volume achieved is based on how much volume can be delivered before the pressure control limit is reached.
Topscom Technology is one of the leading manufacturers and suppliers who is committed to provide customers high quality and customized temperature and pressure controls. Our factory can also give you wholesale service which is made in China, welcome to get temperature and pressure controls with us.


text: Come take an imaginary Easter Sunday trip to Sicily for a concert of sacred music gems and a gut-wrenching drama. First, inside the magnificent cathedral, enjoy treasures by Verdi, Rossini, Franck, and Mascagni. Then, become part of the thrilling Cavalleria Rusticana as a Sicilian villager seated outside the majestic church. You’ll be in the middle of the action and witness how passionate “rustic chivalry” exacts revenge on those who betray others. The opera that lit up the Godfather III finale will unfold before your eyes!


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Communities in Warri North Local Government Area of Delta State, have cried out over the refusal of an oil prospecting firm to pay them adequate compensation for environmental degradation.
The communities affected by the activities of the firm are Olubakagbene 1, Olubakagbene 2, Ibareboteigbene, Tangagbene, Ojorborgbene, Uguregbene, Torusorighagbene, Obeghagbene, Pimougbene, Ebadoughene, Tolosanweigbene and Konuwei/Kunuborgbene.
The residents from ten communities said the oil firm deceived them when they claimed they found no oil in their community, vowing not to allow the firm to remove its rigs and other machinery without making any payment for damages to the community land.
In a statement issued to journalists in Akure, Ondo state, and signed by the community elders, they alleged that several protests carried out for compensation were ignored. The statement said the firm had completed its project and claimed that they found no oil deposits in the affected communities.
“This company, Enixco Ultimate Venture came to the communities without having an agreement with anybody and when the communities involved met with them, they pleaded for their wrongs and promises that Coinoil will do all that we ask for.
“A lot of damage was done to the communities farmland and facilities. The only government primary school at Olubakagbene was affected and no reasonable compensation was given to these communities on these damages.
“We embarked on several peaceful protests but they remained adamant to meet our demands even after the Delta State Government told them to do the needful.
” This ongoing peaceful protest will not stop until all our demands are met. We appealed to the Nigerian Army to call its personnel attached to these companies to order.
They lamented that “We were being threatened in our own land. Nobody can take away what belongs to us in our father’s lands.”

domain: politics


As an automotive writer, it is almost painful to report on technology advances that a “just five years away!” It was with relief that I saw Goodyear’s latest announcement that its new demonstration tire isn’t just a pipe dream but rather one that has passed all applicable regulatory testing as well as Goodyear’s internal testing.
Related Story: Goodyear Introduces a Tesla Model Y New Tire
The new tire is intended to reduce the amount of unsustainable materials used in its construction. The idea being that a tire made sustainably is more environmentally friendly. This jives perfectly with Goodyear's present industry lead as a manufacturer of tires designed specifically for electric vehicles.
The new tire was made with 90% sustainable materials. Goodyear is not in this endeavor alone. Instead, Goodyear is working in conjunction with the entire tire supply chain to accomplish the worthy goal of moving tires toward being more sustainably manufactured.
“We continue to make progress toward our goal of introducing the first 100% sustainable-material tire in the industry by 2030,” said Chris Helsel, senior vice president, Global Operations and Chief Technology Officer. “The past year was a pivotal one toward achieving this goal. We researched new technologies, identified opportunities for further collaboration and utilized our team’s tenacity to not only demonstrate our capabilities to produce a 90% sustainable-material tire, but also to produce a tire with up to 70% sustainable-material content this year. Our team continues to showcase its innovation and commitment to building a better future.”
Related Topic: Goodyear Introduces Two New Tires To Its Wrangler Line
The first way that Goodyear is moving its new tire design toward a greener method of manufacture is by replacing the carbon black presently derived from burning hydrocarbons toward one with carbon black from plant-derived sources. Goodyear is looking at CO2 reduction in this stage of the process.
Next is the use of soybean oils. And the oils are not created specifically for making tires, but are leftover from the feedstock industry.
Since I live in New England, silica is one of my “favorite” tire ingredients. High-silica content tires are the basis of all winter and four-season tires. Goodyear’s demonstration tire compound includes high-quality silica produced from rice husk waste residue (RHA silica), a byproduct of rice processing that is often discarded and put into landfills.
Check back to Torque News for future updates on Goodyear’s efforts to move tires toward a more sustainable manufacturing process. We would jump at the opportunity to test a beta tire on one of our fleet vehicles.
Image of sustainable tire by Goodyear.
John Goreham is an experienced New England Motor Press Association member and expert vehicle tester. John completed an engineering program with a focus on electric vehicles, followed by two decades of work in high-tech, biopharma, and the automotive supply chain before becoming a news contributor. In addition to his ten years of work at Torque News, John has published thousands of articles and reviews at American news outlets. He is known for offering unfiltered opinions on vehicle topics. You can follow John on Twitter, and TikTok @ToknCars, and view his credentials at Linkedin


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I'm finished working in wax for a while. I need to start the last of the polishing the work for Norwescon. The new rings include fossilized dinosaur bone, amethyst (particularly lovely faceting) , moonstone and a large agate that looks in a some what abstract way, like clouds over seas.
I'm still working on the best way to patina bronze black and may have some pieces for Norwescon but I'm not sure yet. I did manage to locate a source for the some beautiful bronze chain I used years ago. One of the opal pendants I talked about in my last post is bronze. It's being stimulating and sometimes fascinating to design with.
Mood:Peaceful (post yoga)


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The Offspring x adidas ZX8000 design draws inspiration from Portland stone, which has been used for centuries to build some of the most exquisite and opulent old buildings in London.
The stone's inherent beige and brown tones have been enhanced by daily wear and tear from the city and centuries-old rainfall. In order to maintain the integrity of the design's inspiration, OFFSPRING employed a combination of soft and high-quality leather, high-quality suede, hairy suede accents, and micro-perforation detailing in colours that were most evocative of Portland stone.
Even the tips of the lace were given a hint of mint green to symbolise the oxidised lead that is present on the rooftops of many London buildings.
© 2024 The Drop Date — All rights reserved


Widening of the Nagapattinam-Thanjavur section of national road 67 remains at a standstill
The delegation asks Nitin Gadkari to restart the improvement works on the Nagapattinam-Thanjavur road
Seeking to break the deadlock in the widening of the Nagapattinam-Thanjavur section of national road 67, a delegation from the delta region informed the Union Minister of Road Transport and Highways of the pitiful state of the road.
The delegation, made up of representatives of the Tiruvarur Development Advisory Board, also urged the minister to take steps to make the road a four-lane highway as originally planned and speed up the project. Led by Mr. Selvaraj, MP for Nagapattinam, the delegation invited Minister Nitin Gadkari to New Delhi to brief him on the situation on the ground.
The unfinished works to widen the section of the Nagapattinam-Thanjavur highway have been a major irritant for residents of Nagapattinam, Tiruvarur and Thanjavur districts as well as for tourists visiting the region. The project, sanctioned at an estimated cost of 396 crore, to strengthen the road as a two-way highway with paved shoulders, has remained unfinished for several years now, despite several unrest from the population.
The poor condition of the road on several sections makes the journeys grueling for thousands of commuters and tourists.
The widening of this section to a total length of 78.53 km should have been completed by the end of 2017 itself. As the section is full of bends and intersecting waterways, widening the road is considered essential for improving road safety and controlling accidents.
“The Thanjavur-Nagapattinam road was originally intended to be transformed into a four-lane highway and the National Highways Authority of India even acquired the necessary land eight years ago. But the proposal was later changed as an extended two-lane road. Even this work is not finished, several years after the start of the work ”, declared S. Ravichandran, president; P.Senthil, secretary, and K. Arungandhi, treasurer, respectively, of the Tiruvarur Development Advisory Board, in the representation, conveying the fate of the inhabitants of the delta region.
Mr. Selvaraj, while approving the representations made by the council and various other organizations in the delta region, asked the minister to prioritize the resolution of the region’s grievances. In the absence of good road connectivity, large hospitals were reluctant to establish full-fledged facilities in the region, he argued.
If there had been good road connectivity, the region could also become a major religious tourist route in southern India, as important and historic temples, mosques and churches were located in the delta, a t -he declares.
Talk to The HinduMr Senthil said the minister granted them a patient hearing and promised affirmative action soon.


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More About Me
Doctor 醫生 | Researcher 研究員 | Writer 作者 | Editor 編輯 | Dreamer 夢想者
One of the most interesting aspects of the transformation occurring in medicine is the effort that some organizations have committed to reexamining the scope of their business. As payment and delivery reform change the landscape of clinical care, some have expanded their reach beyond the delivery of health care into the realm of promoting overall health.
The domain of health care involves what occurs within our clinic and hospital walls, for example, vaccinations, cancer screenings, and care during episodes of acute illness. In contrast, the domain of health requires clinicians to move beyond those walls into the surrounding communities, working with partners to address aspects of health such as food options in schools, the adequacy of services for pregnant women and the elderly, and the like. This movement equates to increased focus on public health and social determinants of health.
As an internal medicine trainee taught to care for patients holistically, I am encouraged by many of the early changes occurring around me. However, early examples are far from perfect, and as health care organizations extend their reach into communities, they must answer several important philosophical and economic questions about the extent of their responsibility. Nonetheless, the effort is laudable.
By now, many people know that our country’s health care costs are unsustainably high, and rising. But the component details — the prices for testing, medications, procedures and hospital stays — have remained arbitrary and opaque even to most health care leaders and physicians, not to mention patients.
Of the many drivers behind our high health care costs, low transparency and consumer awareness are particularly intriguing ones. The idea is straightforward: Without accurate, usable knowledge about how much health care services cost, patients can’t make choices that satisfy both their health needs and their pocketbooks, like they could if they were purchasing cars or refrigerators. For decades, patients have received care without really knowing what it costs.
Access to more information, on the other hand, could allow people to make the economically sensible decisions that drive prices down to more competitive, market-dictated levels. For example, patients needing knee surgery could compare prices from multiple hospitals and choose the highest value option, while providers would have to increase quality and reduce cost to compete for business. The movement towards added transparency and awareness create the potential for patients to shop for their care in ways that have never before been possible.
Some believe that we have made strides over the last few years. Medicare released nationwide information about what prices hospitals and clinics charge, and actually get paid, for everything from joint replacement surgeries to hospitalizations for pneumonia or heart attacks. It then upped the ante by publishing information about what individual doctors charge medicare for their services. With these two releases, anyone can now go to the Medicare website, pull information for a number of doctors or hospitals, and compare their charges against each other.
At least for now, however, shopping thoughtfully for your health care will remain far more difficult than the click of a few buttons. My piece in the Huffington Post about why the price isn’t quite right yet.
I recently received news that one of my professors from medical school—a man who taught tirelessly, with uncommon fire and enthusiasm—stepped down because of a health condition. Like many of my former classmates, my first reaction was one of shock, followed quickly by sadness.
In reflecting on my memories of him and his impact in the weeks since, however, I have also gained a renewed appreciation for the power of mentorship. He was a consummate and effective educator, and has reminded me of a few important lessons to keep in mind as I transition into my final year as a resident.
In my early days as a medical student, the promise of electronic health records (EHRs) was all the rage. In some circles, it was all some researchers, IT leaders, and clinicians could talk about. These enthusiastic conversations touted EHRs as a way to improve clinical decision support, centralize patient information, reduce administrative costs, and share information across health systems (among other reasons). Some saw this new technology as the silver bullet that could help fix health care.
(image from Medtech Boston)
In the years since, the medical community has matured in its understanding of what EHRs can and can’t do. Now that we are pursuing a fuller spectrum of solutions and endpoints – including more business intelligence and patient empowerment – we are faced with a challenging, but worthy, effort.
In this effort, we have to forge forward thoughtfully, careful not to excitedly place our hope in the newest, slickest innovation that claims to improve care (particularly since all of them seem to). Instead, we should utilize the lessons we have learned thus far from EHRs and soberly assess each new innovation. Only then can we remain objective among the myriad of new technologies marketed to improve health, separating real solutions from the promises of new, would-be silver bullets.
As healthcare organizations address issues of inconsistent quality, high rates of harm, and rapidly rising costs, there has been growing interest in how residents physicians - medical school graduates but still doctors in training - contribute to these problems.
Reviewing and acting on performance-related data is an essential competency, but training programs have traditionally not provided housestaff with reliable information about the quality of their clinical performance. Implementation is complicated in a number of ways, but the effort is still crucial.
Several solutions can help educators address this issue, including being transparent about how data will be used, and gaining broad leadership support. My full thoughts here via an article with UCSF’s Bob Wachter.
Empathy is a crucial element to good care and improved patient outcomes.
This isn’t exactly surprising. Within the medical community, and particularly among educators, there has long been an explicit appreciation for humanism and compassion. There has also been a tacit understanding of its importance to doctoring: Empathy is the core quality that every medical applicant tries to convey, the one that admissions committees attempt to identify in candidates.
If the data are to be believed, however, medical education doesn’t always promote empathy, despite all of the recognition of its importance. Reports show that medical students lose measures of empathy as they transition from classroom teaching to clinical clerkships, and other data showing that students can quickly acclimate to unprofessional clinical cultures and behaviors without even recognizing them as such. Reports and anecdotal evidence suggest that this process is likely to continue, or even accelerate, in residency training. Between what we are teaching through explicit didactics and the “hidden curriculum,” the collective messages we transmit to learners in everyday words, actions and behaviors, we may be losing our grip on a sacred professional value and significant gains in our patients’ health outcomes, due to a lack of empathy.
How can we find a better way forward? My thoughts here.
America the beautiful.
In residency, new physicians must learn to appropriately address and handle acute sickness.
In situations involving catastrophic disease (e.g., in intensive care settings), this often requires them to absorb measures of emotion associated with illness while shielding themselves from its full weight. Balanced steadiness in the face of severe illness is crucial—a core competency in its own right—because remaining calm and collected in crisis is often as important to decision making as clinical acumen. Thankfully, most residents learn to find steadiness and focus amid chaos.
This steadiness, however, must also be thoughtfully directed. It is clearly helpful for young physicians who frequently spend long hours dealing with the sickest patients with the most complex medical and social problems. But increased exposure can also ingrain steadiness to the point where it progresses insidiously into something perceived as detachment, particularly by patients on the receiving end of bad news or poor prognoses.
This issue - the cynicism and emotional insulation that can prevent illness from meaningfully moving and affecting residents as people - is something that has concerned medical educators for some time now. Finding balance can be difficult.
There is a curriculum that is at work in medicine that goes beyond the formalized teaching that students receive in the classroom. This “hidden curriculum”—the collection of implicit messages about professional values and practices that are transmitted through everyday words, habits, and interactions—powerfully shapes the attitudes and behaviors of learners, for both better or worse.
While the hidden curriculum can transmit positive messages (e.g. professionalism, humanism, etc), it can unfortunately also create dynamics in which team members, especially those lower in the medical hierarchy (students, trainees), are afraid to speak up about their concerns. In such situations, the hidden curriculum threatens patient safety as well as clinical learning.
This is an important issue within medical education, as well as patient safety. My recent article about this issue here, in Health Affairs.
For over three decades, George Vaillant directed a study out of Harvard, one of the longest running longitudinal studies about human development ever.
Recently, in summarizing the interesting trends and findings from the study, he had this to say in conclusion:
“The seventy-five years and twenty million dollars expended on the Grant Study points … to a straightforward five-word conclusion: ‘Happiness is love. Full stop.’ ”
A more in-depth review of the findings here at the Atlantic.


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domain: chemistry


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T2 Biosystems Announces Patent Covering T2Hemostasis
Published: Feb 05, 2013
LEXINGTON, Mass.--(BUSINESS WIRE)--T2 Biosystems, a company developing direct detection products enabling superior diagnostics, today announced the U.S. Patent and Trademark Office has issued patent 8,344,731 (the ‘731 patent), “NMR device for the detection of analytes”. The patent describes the use of T2MR™ technology to directly detect physical changes within a blood sample, such as coagulation, fibrinolysis, platelet function and other hemostasis properties, as used in T2Hemostasis™ assays. T2Hemostasis is the first technology capable of rapidly characterizing key coagulation, platelet and other hematologic factors directly from whole blood on a single, compact instrument.


Queensland Stay On Your Feet® - Toolkit Phase 3 Communication Plan
Preparing a communication plan
To organise all the communication needed for a project/program, you will need to prepare a communication plan. This involves linking communication objectives, strategies and activities to the project/program plan . It also outlines the type and frequency of information to be presented to relevant target audiences, as well as how and when information will be distributed. While preparing a communication plan takes time, it will improve the project/program’s success and help to keep target audiences and key stakeholders informed about progress.
Please note that a communication plan differs from a more comprehensive social marketing plan. A communication plan simply plans and keeps track of communication activities (allowing process evaluation), whereas a social marketing plan sets measurable objectives for change in the target group as a result of communication activities (allowing impact and outcome evaluation). As a project team, you should decide which type of plan you wish to prepare as only one of these two types of plans is required. Staffing and financial resources may influence this decision.
For more information on social marketing, visit:
Reach and marketing
Preparing a social marketing plan
An easy way to prepare a communication plan is to provide detailed information about the project/program’s communication activities using the following framework:
- why you will communicate (goal)
- what you will communicate (key messages)
- who you will communicate with (target group)
- how you will communicate (communication tools)
- when you will communicate (timing)
- who is responsible for implementing the communication plan (implementation)
- how the plan will be evaluated (evaluation).
To view a sample falls prevention communication plan developed using this framework, visit: Sample falls prevention communication plan
Why you will communicate (goal)
Clearly defining why you are communicating helps to set direction and keep the communication plan in line with the project/program goals, objectives and strategies. This should be set out in the communication plan as the communication goal.
What will you communicate (key messages)
One of the most important things to work out is what you want to communicate about the project. These are called key messages. Identify the main things that individuals, organisations and the community should know about the project/program. Key messages need to be simple, clear and conveyed many times through various sources . It is important to repeat key messages through many trusted sources, make the message stand out from the "clutter" of other information  and develop a message that is personally relevant , as people accept information slowly over time . Individuals, organisations and the community need to understand and act on these key messages.
Who do you need to communicate with (target group)
Identifying who you need to communicate with is referred to as defining your target group. You will need to consider both internal and external groups, as communication for these audiences will be quite different. Target groups for your project/program should be included in your communication plan.
Internal target groups could include:
- the project/program team
- steering committee or other advisory group
- consultants and advisers
External target groups could include:
- older people and their families and carers
- stakeholders, including supporters of the project/program
- health professionals, including GPs and occupational therapists
- the community
- funding body.
How will you communicate (communication tools)
The best communication tools to use will depend on your target groups and the type of information to be communicated. For example, tools used to communicate with the project/program team are likely to be different to those used to communicate with stakeholders and the community. Common communication tools include:
- interpersonal communication (eg. talking individually or in small groups, holding meetings)
- public speaking (eg. giving presentations at seminars, lectures, workshops, forums and conferences)
- printed materials (eg. leaflets, brochures, fact sheets, newsletters, updates)
- media (eg. articles in community newsletters, media releases generating newspaper articles and radio/television interviews, paid advertising)
- internet (eg. email newsletters, website, web discussion groups, web seminars or ‘webinars’)
- satellite broadcasts, video conferencing and teleconferencing
- project/program progress reports, intermediate reports, and final evaluation reports.
It is difficult to reach everyone that the project/program is targeted at, so ensure you develop communication networks  such as:
- a group email list
- mailing list database
- key stakeholders, who take the message back to their organisation, clients and local community
- volunteers/ambassadors, who spread the message among their peers.
|When communicating with…||Consider …|
|individuals||working with health professionals, as they are considered a trusted source of information|
|project/program team or steering committees||project updates|
face to face meetings
|funding bodies||formal progress and final reports|
face to face meetings
email and telephone contact
|organisations||meetings with decision makers|
speaking at staff training meetings
|community||large public events|
mass media (newspapers, radio and television)
Do not underestimate the power of word-of-mouth communication (also known as ‘the grapevine’). This is when a person tells another about your project/program. Messages can be passed on in many ways, including through face-to-face contact, telephone calls, text messages and email. This type of communication is powerful because the person spreading the message is known to the receiver and is considered a trustworthy and credible source.
To inform people about your project/program, try attending existing meetings of community groups, rather than holding additional meetings and expect people to come to them . By attending established meetings, people don’t have to decide which one they will attend. The Rural Chronic Disease Initiative projects found this strategy very useful .
Who is responsible for implementing the communication plan?
You will also need to consider:
- who is responsible for preparing communication material for the project/program
- how communication material will be approved, and by whom
- when will communication activities be undertaken
- whether there are relevant cultural issues (eg. need for translation of brochures)
- how privacy legislation may affect your project/program .
How will the communication plan be evaluated?
To allow process evaluation of your communication efforts, you will need to record your communication activity using simple measures such as:
For more information on process evaluation, visit: Phase 4: Review


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Berdent History, Family Crest & Coats of Arms
Berdent is a name of ancient Anglo-Saxon origin and comes from the family once having lived on a barley farm. Checking further we found the name was derived from the English word barton which originates in the two Old English words bere, which means barley, and tun, signifying an enclosure.
Early Origins of the Berdent family
The surname Berdent was first found in Cheshire at Barton, a township, in the parish of Farndon, union of Great Boughton, Higher division of the hundred of Broxton. "The manor [of Barton] was anciently held under the barony of Malpas by the family of Barton, some monuments of whom, with their effigies, were formerly to be seen in Farndon church."
Over in Barton-Upon-Irwell in Lancashire another branch of the family was found. "Barton Old Hall, a brick edifice, now a farmhouse, was the seat successively of the Barton, Booth, and Leigh families."
Bearton was the name of a small hamlet near Hitchin in Hertfordshire, but was amalgamated about 100 years ago to be known as Hitchin Bearton.
Early History of the Berdent family
This web page shows only a small excerpt of our Berdent research. Another 158 words (11 lines of text) covering the years 1015, 1163, 1304, 1506, 1534, 1534, 1466, 1511, 1474, 1475, 1562, 1597, 1610, 1597, 1506, 1534, 1506, 1525, 1598, 1678, 1614, 1684, 1659, 1681, 1797 and are included under the topic Early Berdent History in all our PDF Extended History products and printed products wherever possible.
Berdent Spelling Variations
Sound was what guided spelling in the essentially pre-literate Middle Ages, so one person's name was often recorded under several variations during a single lifetime. Also, before the advent of the printing press and the first dictionaries, the English language was not standardized. Therefore, spelling variations were common, even among the names of the most literate people. Known variations of the Berdent family name include Barton, Barten, Bartin and others.
Early Notables of the Berdent family (pre 1700)
Notables of this surname at this time include: Sir Andrew Barton (1466-1511), High Admiral of the Kingdom of Scotland, but regarded by the English and Portuguese as a pirate. His "defeat by Sir Thomas and Sir Edward Howard is celebrated in the old ballad of 'Sir Andrew Barton,' was the son of John Barton, who is mentioned in the account of the chamberlain of Fife, 1474-1475, as master of the Yellow Carvel, subsequently rendered famous under Sir Andrew Wood. "
Edward Barton (1562?-1597), was the second English ambassador sent to Constantinople, and was probably the second son of Edward Barton of...
Migration of the Berdent family to Ireland
Some of the Berdent family moved to Ireland, but this topic is not covered in this excerpt.
Migration of the Berdent family
For political, religious, and economic reasons, thousands of English families boarded ships for Ireland, Canada, the America colonies, and many of smaller tropical colonies in the hope of finding better lives abroad. Although the passage on the cramped, dank ships caused many to arrive in the New World diseased and starving, those families that survived the trip often went on to make valuable contributions to those new societies to which they arrived. Early immigrants bearing the Berdent surname or a spelling variation of the name include: Jane Barton who settled in Barbados in 1654; Nicholas Barton settled in Virginia in the same year; Robert Barton settled in Virginia in 1637; William Barton settled in Jamaica in 1654.
The motto was originally a war cry or slogan. Mottoes first began to be shown with arms in the 14th and 15th centuries, but were not in general use until the 17th century. Thus the oldest coats of arms generally do not include a motto. Mottoes seldom form part of the grant of arms: Under most heraldic authorities, a motto is an optional component of the coat of arms, and can be added to or changed at will; many families have chosen not to display a motto.
Motto: Fide et fortitudine
Motto Translation: By fidelity and fortitude.

domain: library


The Division of Communications often receives requests for video coverage of various events on campus. The University does not employ a staff videographer and is limited in the ability to videotape/record events.
The Division of Communications prioritizes those events that have broad public interest and student recruitment potential for use in social media, media relations and advertising/marketing activities. We are not able to videotape or record lectures, speaker series, meetings, athletics events, or dance, music and theater events that do not meet these criteria.
All requests received are subject to administrative approval. Approved requests are processed in the order they are received.
Note: completion time for approved requests can take up to four to six weeks or longer depending upon previous commitments, current workload, and/or timeliness.


These Safety First ergonomic maintenance stands are custom-designed for the US Army’s UH-60. They are uniquely developed to fit and function in the tight-spaced hangar layout of the Yuma facility.
The Safety First ergonomic stands allow technicians SAFE access to all areas of their UH-60 aircraft. The stands are equipped with the latest features including a seamless fit to the aircraft with access to the main rotor, engine, transmission, flight controls, tail boom, drive shafts and tail rotor. The aircraft-specific design of the stands increases safety and efficiency. SAFE has been working alongside the US military in various locations to provide these innovative designs that are custom designed for both aircraft and location including the US Army National Guard UH-60 and the US Coast Guard MH-60.
Equipment fits the Army’s unique challenges
“We are proud to supply the US Army with more UH-60 maintenance support equipment that fit their unique challenges,” said Johnny Buscema, SAFE CEO. “There are no other stands on the market as effective and efficient as our custom designs. This support equipment is designed to provide personnel with safe and efficient access for all maintenance. We have provided similar custom support equipment for a wide range of helicopters and airplanes in both the civilian and military sector.”
Recently, the US Army Aeromedical Research Laboratory has successfully completed initial prototype flight-testing on Vita’s Load Stability System Litter Attachment.


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With the rise of cryptocurrency and the popularity of decentralized networks, many people are looking for ways to enter the P2P lending market. While traditional banks offer a number of services, they also come with some downsides (e.g., high fees). In this article, we will explore how blockchain technology is changing P2P lending by bringing transparency to an otherwise opaque process.
Blockchain technology has enabled the emergence of a new type of P2P lending market where borrowers and lenders are able to enter into an agreement without the need for an intermediary. This is possible because blockchain transactions self execute with trustless smart contracts that provide proof once funds have been transferred. According to DeFi Pulse, which provides analytics on decentralized finance projects, as much as $29 billion worth of value was locked in such agreements at the time this article was written (September 2020).
With decentralized networks like Ethereum’s Smart Contracts platform powering loans between parties, many people are looking for ways to get involved in these types of financial services outside traditional banks. Decentralized networks may be more attractive than centralized ones due to the ability to maintain a private financial profile.
Lending Platforms with Blockchain Technology:
The SALT lending platform is trying to give people more options for accessing loans outside of traditional banks by allowing them to pledge cryptocurrency as collateral on their loan agreements. This allows borrowers who may not have access to credit cards or other forms of financing an opportunity when they might otherwise be unable create any sort of leverage in obtaining funds from a bank.
One potential downside that could arise out of this type of agreement between borrower and lender is the risk associated with fluctuating cryptocurrency prices, which can lead to defaulted payments if the value drops before repayment occurs. For those looking for ways around such risks, there are some decentralized exchanges that offer crypto-backed stable coins prices of cryptocurrency. Regardless, the SALT lending platform has a system in place to hedge against any potential negative outcomes associated with price fluctuation by keeping some percentage of the collateral value locked into their USD-backed crypto baskets.
Cryptocurrencies have changed how people transact and exchange goods on an international level, but what about within a local economy? Local economies will benefit from cryptocurrencies as well if they choose to accept them as payment for goods or services rendered. This gives those who may not be able to participate in global markets due to volatile shifts in currency prices access to wider pools of capital that are more readily available than traditional currencies.”
The post Cryptocurrency and the P2P Market: Bringing Transparency to Lending By Utilization Blockchain Technology appeared first on Crypto Disrupt. With the advent of cryptocurrency, the P2P market continues to evolve as decentralized networks and smart contracts present new avenues for accessing financial services outside of the traditional banking infrastructure. Utilizing blockchain technology, borrowers and lenders are able to enter a loan agreement without the need for an intermediary. Instead, self-executing smart contracts enable trustless transactions according to DeFi Pulse, a DeFi analytics and rankings publication $$$$billion of value was locked in the DeFi lending market as of September 2020 with price fluctuations.


The European Commission’s Scientific Committee on Consumer Safety has proposed a reduction to the maximum concentration limit that applies to leave-on cosmetic product o-phenylphenol.
Under current EU cosmetics regulations, the ingredient features in cosmetics at a maximum concentration of 0.2 percent. However, a 2014 risk assessment by the French agency for the safety of medicines and health products (ANSM) led the Scientific Committee on Consumer Safety’s to re-evaluate the safety of the ingredient as studies have suggested that o-phenylphenol can have a dispruptive effect on hormone production.
The Committee now states that a maximum concentration of 0.2 percent for o-phenylphenol as a preservative in leave-on cosmetics is not safe, yet the committee has not flagged up concerns over the same limit in rinse-off products.
The committee’s recently published opinion is open for comments until August 21.