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text:
A unique and exciting introduction to the genre and craft of historical fiction, for curious students, aspiring authors--anyone with a passion for the past. Read classics of the genre, encounter bestselling writers of historical fiction, and discover your own historical archive while interacting with a global community of interested readers.
Les épidémies, les sorcières et la guerre : le monde de la fiction historiqueUniversité de Virginie
À propos de ce cours
Université de Virginie
A premier institution of higher education, The University of Virginia offers outstanding academics, world-class faculty, and an inspiring, supportive environment. Founded by Thomas Jefferson in 1819, the University is guided by his vision of discovery, innovation, and development of the full potential of students from all walks of life. Through these courses, global learners have an opportunity to study with renowned scholars and thought leaders.
- 5 stars70,83 %
- 4 stars21,21 %
- 3 stars4,54 %
- 2 stars2,08 %
- 1 star1,32 %
Meilleurs avis pour LES ÉPIDÉMIES, LES SORCIÈRES ET LA GUERRE : LE MONDE DE LA FICTION HISTORIQUE
An excellent presentation from the professor on historical fiction. Yet, I feel the title of his class
is alittle misleading.
Exceptional experience. I enjoyed the entire course. This was my first real sojourn into the genre and now I'm hooked. Thank you, very much, for sharing this quality education. Be Well.
Exceptional lead instructor and guest speakers. Added tremendously to my knowledge of the genre, even though I am an author of historical fiction with a PhD in History.
A very interesting course. Only negative thing is that some of the authors are not very good at leading a lecture, and seem to stumble in their words a lot.
Foire Aux Questions
Quand aurai-je accès aux vidéos de cours et aux devoirs ?
À quoi ai-je droit si j'achète le Certificat ?
Une aide financière est-elle possible ?
D'autres questions ? Visitez le Centre d'Aide pour les Étudiants.

domain: literature


text:
Bollywood actress Sonam Kapoor, who is currently occupied with the promotions of her upcoming film The Zoya Factor, recently opened about how the Hindi film industry still hasn't reached a point where she could lead a big-budget commercial film like Hunger Games.
Sharing that she is still struggling to find her own space in Bollywood, Sonam said that she was once having a similar discussion with her father and veteran actor Anil Kapoor who advised her to create her own roles. From then on, Sonam said that she has tried to take up roles and films where she could eventually in her “own small way, be able to open up a Friday”.
“We have not yet got to that point where I can ever end up doing a Hunger Games, where we have that kind of budgets. But like even with Neerja and Khoobsurat, I wanted to be able to do that, also with Veerey (Di Wedding). I know that the producers are happy putting money into a film like that and I worked. I really worked hard in the hope that one day I am at a point where I am not dependent on any man, to kind of make a film with me in my life. I think that is the only way forward because I anyway wasn’t getting those roles. I didn’t have big heroes wanting to work with me and so it was fine. I was fine, doing my own thing. Except for maybe few like Salman (Khan) and Akshay (Kumar),” explained Sonam in an interview with Zoom TV.
The actress then quipped that she doesn't think Akshay will ever cast her in a commercial film like Thank You. To explain her point, Sonam narrated an anecdote where Akshay once pointed out that Sonam was awkward on a certain film set, as she was confused as to what all was happening there.
She joked, “He mentioned to me about how awkward I was on that set and said, you just stood that in the set and looked around like “what’s going on here”, but he did say that Padman ke jaisi film tu kar sakti hai.”
Having last graced the big screen last year, Sonam was seen in Ek Ladki Ko Dekha Toh Aisa Laga, co-starring Juhi Chawla, Rajkummar Rao and Anil Kapoor in lead roles. The film opened to positive reviews and was appreciated by the audiences at large. Her next screen outing, The Zoya Factor, co-stars Malayalam heartthrob Dulquer Salmaan. Slated for a release on September 20, the film has already got the viewers excited.

domain: entertainment


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Traditionally viewed as a significant cost center for health systems, pharmacies experience substantial pressure to contribute to cost cutting mandates while not sacrificing service levels or compromising medication availability. Forward-thinking organizations are addressing these challenges by centralizing supply chain and pharmacy operations offsite at consolidated service centers (CSCs).
Consolidated service centers enable health systems to automate and centrally manage inventory and healthcare logistics for all supply chain and ancillary support services. This cost-disruptive model facilitates reduction of supply chain complexity to streamline operations and drive standardization.


text:
There was no one to pump his flag outside the Port-of-Spain Magistrates Court yesterday after soca superstar Machel Montano was found guilty on four counts of assault and using obscene language. Equally, there was no "palancing" taking place as songwriter/producer Kernal Roberts was also found guilty on two counts of assault.
The two will know their fate when they reappear before magistrate Maureen Baboolal-Gafoor in the Seventh Court on January 17. Fellow artistes-Joel "Zan" Feveck and Rodney "Benjai" Le Blanc-who were jointly charged with Montano and Roberts, walked out of the court free men after they were acquitted on two counts and one count of assault respectively.
Leaving the court minutes after the decision was handed down Roberts and Montano and his entourage hurried along Duke Street to escape the cameras. Both refused to comment. Wearing a sombre expression, Montano's mother and manager Elizabeth Montano also refused to comment as she rushed to catch up with the group at the corner of Abercromby and Duke Streets.
Montano's bodyguard ensured the media kept a safe distance from the group. Montano, 37, created history when he captured the Road March, Power Soca Monarch and Groovy Soca Monarch titles earlier this year. The four men went on trial in 2008 and yesterday's decision was delivered after an adjournment on November 23. It was the fourth time that the matter had been listed for decision and was adjourned.
After delivering her ruling, Baboolal-Gafoor heard from Montano's attorney Dana Seetahal, SC, who provided a brief synopsis of the events that led up to yesterday's ruling. Seetahal said the offences occurred five years ago and arose out of one incident.
Petitioning the magistrate to take into account the length of time that had elapsed since the charge was laid and the outcome, Seetahal urged Baboolal-Gafoor to consider that Montano had no previous convictions or pending matters and up until five years ago had "had no brush with the law up to that time."
Machel Montano found guilty
Saying Montano's life was an open book and his artistic and musical ability were well known throughout the Caribbean and further afield, Seetahal referred to Montano as "an ambassador of T&T in music and singing and his whole life, as it were."
Pointing out that Montano had been celebrating his Road March win in 2007 when the incident occurred, Seetahal said Montano had not initiated it, as he had been "going about his business enjoying himself with friends and not bothering anyone" when he was approached by the victims, who began wining on him.
Seetahal said after Montano refused to indulge one of the victims a second time a drink was spilled, the fracas began inside and continued outside the club. She appealed to the magistrate to consider the gravity of the offences and ensure the punishment was commensurate with each offence.
Arriving in court out of breath after being summoned from the Appeal Court at the Hall of Justice, Roberts' attorney Keith Scotland appealed for his client to be given community service. "In the life of the second defendant (Roberts), this must be an aberration," Scotland said.
Telling the magistrate that Roberts, 31, was a dedicated father of three who lived at the Rain-O-Rama Palace, Diego Martin, Scotland said he had a clean record and was a "prolific producer" who had written hits, such as Band of the Year (2006), Jumbie (2007), Palance (2010), Advantage (2011) and Pump Your Flag (2012).
Urging Baboolal-Gafoor to consider the time, place and context of the events as they had unfolded five years ago, Scotland cited cases in similar circumstances where public figures had been before the court as he said: "This defendant has the opportunity to make a substantial contribution for the rest of his life."
Revealing that Roberts was a motivational speaker in the Diego Martin and Morvant communities and could not be counted as a "repeat offender," Scotland said Roberts' career often took him to the US, Canada and Europe, "sharing the culture of T&T." Telling Scotland she could not consider community service until a probation officer had completed reports on both men and their suitability to perform it, Baboolal-Gafoor ordered that reports be done.
She reserved sentencing until next year, when the reports will be submitted, after which Montano's and Roberts' sentences will be determined. Speaking to reporters, Le Blanc said: "I feel vindicated" while Feveck said: "This has been a long time in coming and it is now over for us."
Asked how they felt about the guilty verdict handed down in respect of Montano and Roberts, Le Blanc said: "We are supporting them 100 per cent throughout." Feveck was represented by Larry Williams while Rajiv Persad and John Heath appeared on Le Blanc's behalf. George Busby prosecuted the matter. The possible penalties:?
The assault charges were laid under Section 14 of the Offences Against the Person Act, which says: "Any person who unlawfully or maliciously wounds or inflicts any grievous bodily harm upon any other person either with or without a weapon or instrument is liable to imprisonment of five years."
Scotland said yesterday the magistrate had a wide spectrum of options available to her when sentencing, including imprisonment, a fine, bond, community service order and compensation. The obscene language charge carries a maximum fine of $200.
Why haven't they appealed??
Keith Scotland, Kernal Roberts' attorney, explained yesterday evening in a phone interview that attorneys must wait until sentencing before raising the question of an appeal.
Still no comment
Up to yesterday evening, Montano's phone was going straight to voice mail. Attorney Dana Seetahal, SC, could not be reached for comment. A woman who answered Elizabeth Montano's phone yesterday evening said Montano was on another line but she might return the call to the T&T Guardian later.
Assaulting Russell Pollonais:
Guilty:?Machel Montano and Kernal Roberts
Not guilty: Joel "Zan" Feveck and Rodney "Benjai" Le Blanc
Assaulting Brandis Brown:
Guilty: Machel Montano, Kernal Roberts
Not guilty: Joel "Zan" Feveck
Assaulting Gerard Bowrin, occasioning actual bodily harm:
Assaulting Janelle Lee Chee, occasioning actual bodily harm:
Guilty: Machel Montano
Using obscene language:
Date of the incident:
The four men were charged following a fracas outside the nightclub at Keate Street, Port-of-Spain, on April 26, 2007.

domain: news


text:
Baroness formed in 2003 in Savannah, GA, comprised of a group of friends who grew up together in Lexington, VA, a small town in the Blue Ridge Mountains.
Shortly after their formation, the band released two EPs and a split EP with Unpersons entitled respectively, First, Second andA Grey Sigh in a Flower Husk. From their origin right through the release of these EPs, Baroness toured non-stop throughout America and Europe, building up a steady underground fan base.
In late 2006, the band began working… Show more
Created by ZventsOSA | Claim this event
|$41 to $44||Buy Now|
279 Tremont St.
Boston, MA 02116

domain: artistic


text:
Washington, DC – During the COVID-19 Public Health Emergency (PHE), the Centers for Medicare & Medicaid Services (CMS) implemented flexibilities to help people across the country get on, and stay on, Medicaid. As these adjustments were primarily intended to address the effects of a rapidly evolving pandemic, many flexibilities were set to terminate at the end of the PHE. However, Congress recently passed the Consolidated Appropriations Act of 2023, which set the end date of the Medicaid continuous coverage requirement as March 31, 2023. As a result, state Medicaid agencies will begin the process of redetermining Medicaid eligibility as early as today. The first Medicaid terminations can happen as early as April 1, 2023.
“A significant component of the COVID-19 PHE was an enormous increase in state Medicaid funding on the condition that states could not kick people off of Medicaid until the end of the declared emergency,” said Alicia Emanuel, senior attorney at the National Health Law Program. “This guaranteed that no one lost access to health coverage during the pandemic, which was critical as intersecting inequities made low-income communities and communities of color more susceptible to the impacts of COVID-19. Now that the Medicaid continuous coverage requirement has been decoupled from the end of the PHE, states will move to redetermine eligibility of Medicaid enrollees, which has the potential to result in a massive loss of Medicaid coverage. Advocates must work with communities, state Medicaid agencies, and policymakers to ensure that the unwinding process does not exacerbate existing inequities in health care access.”
“Across the country, millions of eligible individuals and families could lose coverage, and many more will be forced to navigate complex and confusing re-enrollment processes,” said Sarah Somers, Legal Director at NHeLP. “The National Health Law Program and our state-based Health Law Partnerships have been preparing for the PHE unwinding and are ready if state Medicaid programs improperly terminate eligible people.”
The National Health Law Program and our partners are committed to supporting advocates on the ground as we work towards a smooth Medicaid unwinding process that preserves Medicaid coverage for all who remain eligible.
Learn more about the Medicaid unwinding process and find additional resources here.

domain: medical


While supplies last! Kids can come make a commercial from scratch at the library! Don't wait! This may be your last chance for this one-of-a-kind opportunity! And at only 0% APR! Registration is requested. Click the "Register" button and complete the form, register at the Computer Training Center, or call the library. Registration opens two weeks before the event.
Financial assistance for this special project is made possible with Federal funds from the Institute of Museum and Library Services administered through the Oklahoma Department of Libraries.


text:
From THE COMICS TREADMILL:
“I hate Sundays. Sure, it’s a day off, but in the back of my head, a nagging voice kicks in around two o’clock that reminds me that my freedom ends in a few short hours. Moodiness and a general sense of malaise set in, making life difficult around the house for anyone who isn’t me. Some things can help dispel the cloud of doom: scotch, Manhattans, good ice cream, and steak grilled to perfection have been known to bring a sense of normalcy to stately Mag Manor. Today, however, a stack of comics from Boom! Studios‘ Ross Richie did the trick.”
ZOMBIE TALES: DEATH VALLEY #2:
“the creators dish out an excellent plate of zombies and high school angst. It’s typically good fare from Boom!.”
PLANETARY BRIGADE #1:
“My favorite line: would you like me to pour you a martini? Comics need more lines like that. Disturbingly, I may have to re-evaluate my opinion of the Giffen and DeMatteis Justice League if I keep enjoying their work so much.”
WAR OF THE WORLDS: SECOND WAVE #1:
“Boom!’s third bit o’ joy was War of the Worlds: Second Wave by Michael Alan Nelson, with art by Chee. I was going to simply say that this issue was pretty much set-up for the rest of the series, but then I realized that Nelson managed to summarize Wells’ well-known story without appearing stale. That’s not a bad piece of work. And, I’m looking forward to the second issue. The second wave of the Martian invasion has plenty of potential.”
From BEST SHOTS at NEWSARAMA:
“War of the Worlds: Second Wave #1 (Boom!; by Troy): Confession time: my favorite adaptation of WotW has always been the late â€˜80s syndicated TV series. Still, I think that the version related in this first issue holds up well. We see the story from the perspective of one man, separated from what matters most to him by bad luck, circumstance, and aliens. The art by Chee is solid, and the script by Michael Alan Nelson adequately captures the pain and numb anxiety one would feel in similar circumstance.”
“And the art by Chee is beautiful. It has a gorgeous painted style that fleshes out all the characters in a realistic fashion, and there are some terrific action layouts. The aliens look great, and the destruction is awesome in its aftermath; it could be still frames from a film. The coloring by Webb enhances the painted look of the art expertly.
Wow, was this so much better than I ever expected. An enjoyable story thatâ€™s slick without being shallow, and action intensive without skimping on the impact of violence, this is the type of impressive Boom! Studio comic Iâ€™m used to. A set up issue, but I canâ€™t wait for number two. Out this Wednesday.”
“At this point, I feel like I should say something hypercomplimentary about Ross Richie and Boom! Studios, as he’s been so kind to link to me twice in the past week. Thankfully, I’ll only need to add the smallest bit of superlative prose to any review of the second part of Zombie Tales: Death Valley, which went down quite nicely with my iced coffee.”
Boom! Studios, p.240
Again, this is a challenge to my four-dollar-comics rule, but I’m curious. I’m getting hints at a connection to Flight #93, the One that Fought Back. Could just be my post-9/11 shakes and shivers, though. What we know for sure is that “[w]hen Flight 654 goes down, it takes 148 souls with it. But not Nicholas Dane. How did the 34-year-old college professor survive – was it a miracle? Now Nicholas now finds that he has the memories and skills of one of the passengers from the flight – a boxer – and he’s got to use them to survive!” Interesting premise; I’ll take a look at this one.
Boom! is also putting out issue #3 of War of the Worlds: Second Wave, which I first spotted back in December. The solicit for issue #3 is on page 241 and the cover looks pretty smokin’. I’m waiting for this month’s first issue with baited breath.
Over the past five years, the number of exclusive creators signing with either DC Comics or Marvel has increased exponentially. Practically at every comics convention held across the country at least one exclusive ends up announced, with Peter David‘s announcement two weeks back at WonderCon being one of the most recent. And we’ll probably hear an exclusive announcement or two at this upcoming weekend’s New York Comic-Con. At times the sheer volume of exclusive announcements can take on an almost comedic tone, but the exclusive announcement we’re talking about right now is a very serious one indeed: Keith Giffen & J.M. DeMatteis are taking the Bwah-Ha-Ha exclusively to Boom! Studios.
Boom Studios!First it was zombies, now it’s the Lovecraftian mythos with the debut of Cthulu Tales where the usual people that show up for Boom! anthologies, including internet pal John Rogers. Also coming out from Ross Richie’s little publisher that could, can, and will is Talent #1, which seems to have a hook that I’ll appreciate, even if I’ve never seen the referenced-in-the-ad Lost due to only wanting to care about one TV show at a time and right now, Katee Sackhoff has my heart.
From COMICS SHOULD BE GOOD:
Different creators have different track records when reunited together for projects that evoke past works the creators have done together, so it is often a crap shoot. Therefore, Kieth Giffen and Alan Grant teaming up for a new series involving both an alien prison break (their L.E.G.I.O.N. series) and a hardass mercenary (their Lobo series) could go either way. Luckily for us, Jeremiah Harm falls in the camp of “good comic book.”
from THE SCOOP, on JEREMIAH HARM #1:
“As a whole, I really enjoyed this issue, in had plenty of dialog, so it wasn’t over in 2 minutes, and I am a sucker for cliffhanger endings, and I am very much looking forward to next issue. Boom! Studios recently got publisher of the year honors, and with books like this, it’s not difficult to see why.” — THE COMICS REVIEW
“Planetary Brigade is a glorious resurrection of all that made JLI so much fun, with the rapid-fire series of jokes bolstered by nonstop superhero action. It’s ridiculous. Finally.” – Shaun Manning at Silvebulletcomicbooks.com
“Missing your Justice League and Super-Buddies fix? Tired of the angst-ridden ICkie DC universe? Then plant your dollars on the counter of your friendly, neighborhood comic book store and buy Planet Brigade.” – Ray Tate of Silverbulletcomicbooks.com

domain: hobby


text:
I broke today -- after a morning coffee with the eldest child, I headed for the local nursery to pick up an early birthday present for me. Seedlings! I got two six packs of leeks (with 2-8 leeks per pot), two six packs of lettuce mixes, two six packs of asparagus, and a single potted artichoke. The front yard artichoke was split but the transplanted half thrived and the original half dwindled to almost nothing, so I figured a jump start was in order.
I've been so behind with the seedlings downstairs that I wonder if I'll ever see seed-started lettuce! It's just been a bad winter, garden-wise.
So the jump start seemed to be all I needed. In a break in the rain, I raked smooth the bed infested with potato scab, and put in, with many incantations to the spring goddesses, a dozen feathery asparagus babies.
It strikes me that planting asparagus is a really optimistic gardening move. It says that you're going to be around for at least the next few years, just to coax the plants along. Since these were seedlings, not large crowns, it may be up to four years before I get to eat anything. Oh well, it keeps me busy!
The leeks filled a small bed and half a large bed. Before the lettuce could be sited, the rain opened up again and I headed inside. There a flat waited, so I seeded two kinds of kale and about eight different kinds of lettuce. My version of succession planting -- nursery seedlings AND home-seeded ones! Whatever gets you eating, I suppose.
In distressing news, the garden kale is going to seed, and I didn't succession seed well enough to have more at the right point. So I may end up (gasp) buying kale to eat. Now I wish I'd frozen some!
Friday Unfavorite: Wild Turkeys
5 hours ago

domain: agronomy


text:
Difference between revisions of "Kombucha"
(Created page with "==Green Tea Kombucha== * https://www.thehealthymaven.com/2013/04/orange-green-tea-kombucha.html ===Ingredients=== * 3 green tea bags * 16 cups water * 1 cup of sugar * 1 SCOB...")
Revision as of 19:20, 10 June 2018
Green Tea Kombucha
- 3 green tea bags
- 16 cups water
- 1 cup of sugar
- 1 SCOBY
- 1/2 cup already brewed Kombucha (can use store bought)
- 2 large oranges
- Bring water to a boil. Turn off stove once the water has boiled. Add tea bags and sugar to water. It’s important to let it cool to room temperature.
- Add the SCOBY and the 1/2 cup of Kombucha starter Into a large jar.
- Add room temperature sweet tea into the jar. Cover jar with a dish cloth and secure with a rubber band.
- Leave in a cool, dark place for 7 to 14 days (depends on the temperature).
- Once you think your Kombucha is ready, wash your hands thoroughly and remove the SCOBY by hand.
Green Tea Kombucha v1
- Brewed for 14 days (weather in the 70s)
- Carbonated for 3-4 days
- I skipped adding the fresh squeezed orange juice
- Success: Unique green tea flavor. But should use spring water next time, not tap water.

domain: food


text:
“We’re proud of our many accomplishments and look forward to continuing the success of the Lottery as we generate revenue to educate the next 100,000 students,” said David Barden, New Mexico Lottery chief executive officer.
“Our 10th year is shaping up to be another record-breaking year,” said Alice Garland, executive director of the N.C. Education Lottery. “We know we are going to surpass our goal for the year. The question now is how far beyond $529 million will our earnings go. Every one of those extra dollars will help make a difference for education in North Carolina.”

domain: economics


text:
STARKE, Fla. — A group of atheists unveiled a monument to their nonbelief in God on Saturday to sit alongside a granite slab that lists the Ten Commandments in front of the Bradford County courthouse.
As a small group of protesters blasted Christian country music and waved “Honk for Jesus” signs, the atheists celebrated what they believe is the first atheist monument allowed on government property in the United States.
“When you look at this monument, the first thing you will notice is that it has a function . . . we selected to place this monument in the form of a bench,” said David Silverman, president of American Atheists.
It also serves another function: a counter to the religious monument that the New Jersey-based group wanted removed. It’s a case of if you can’t beat ’em, join ’em.
American Atheists sued to try to have the stone slab with the Ten Commandments removed from the courthouse lawn in this rural, conservative town in northern Florida. The Community Men’s Fellowship erected the monument in what is described as a free-speech zone. During mediation on the case, the atheist group was told that it could have its own monument, too.
“We’re not going to let them do it without a counterpoint,” Silverman said. “If we do . . . it’s going to appear very strongly that the government actually endorses one religion over another, or — I should say — religion in general over non-religion.”
About 200 people attended the unveiling. Most were supportive, although there were protesters, including a group from the Florida League of the South that had signs that said, “Yankees Go Home.”
“We reject outsiders coming to Florida . . . and trying to remake us in their own image,” said Michael Tubbs, state chairman of the Florida League of the South. “We do feel like it’s a stick in the eye to the Christian people of Florida to have these outsiders come down here with their money and their leadership and promote their outside values here.”
After the 1,500-pound granite bench was unveiled, people rushed to have their pictures taken on it. The bench bears quotes from Thomas Jefferson, Benjamin Franklin, John Adams and Madalyn Murray O’Hair, the founder of American Atheists. It also has a list of Old Testament punishments for violating the Ten Commandments, including death and stoning.
At one point, Eric Hovind, 35, of Pensacola, Fla., jumped atop the peak of the monument and shouted his thanks to the atheists for giving him a platform to declare that Jesus is real. Atheists shouted at him, and he stepped down after about a minute.
Hovind and Tubbs did say that they respect the right of the group to install the monument, even if they disagree with the message behind it.
And the atheists said they expected protesters.
“There always are,” said Rick Wingrove, director of a Washington, D.C., area office of American Atheists. “We protest their events, they protests our events. As long as everybody’s cordial and let people speak. This is our day, not theirs. We’re fine with them being here.”
— Associated Press

domain: sociology


The Context widget displays the currently active:
- filters (selected facet values)
- sort criterion (afs:sort)
- feed (afs:feed)
- virtual fields
- search keywords (configurable)
In order to work, this widget requires the Facets widget to be present.
Use the pinsMode configuration parameter to configure what happens when a search form is submitted? Are the previously visible/selected facets removed or kept?
- makes all the facets persistent (default). That is they are said to be persistent because they persist across searches. They still apply from one search to another as long as you do not remove them. Considering the above snapshot, when submitting the search form all previously selected facets are kept and still filter the new search results.
- Makes no facet persistent. When you search all previously selected facets are un-selected and do not apply to the new search results. Considering the above snapshot, all the facets except the feed are removed when submitting the search form.
- Makes only the pinned facets persistent. When in this mode a pushpin button is displayed, next to the facet label in order to for you to choose the facet(s) you want to make persistent:
- pin a facet to make a visible facet (aka. active filter) persistent across searches.
- unpin a previously pinned facet, making it no longer persistent.
Considering the above snapshot, the only facet removed when submitting the search form is the "Categorie: Soldes" because it is not thumb tacked. The feed facet is a special case and the pushpin does not apply to it.
The above values are case-sensitive.
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Dan Girardi will return to the Rangers' blue line for Sunday's match with Arizona.
Dan Girardi (groin) felt good after participating in Friday's practice.
Dan Girardi (groin) remains questionable for this weekend.
Dan Girardi (groin) might skate on his own Thursday, according to coach Alain Vigneault.
Dan Girardi has been ruled out of Monday's game against San Jose due to a groin strain.
Dan Girardi suffered a hip flexor in the second period Saturday and did not return.
Dan Girardi doesn't feel he needs to enter the season with a "chip on his shoulder."
The New York Rangers will reportedly not buy out Dan Girardi's contract.
Dan Girardi is confident that he can bounce back from his less than ideal 2015-16 campaign.
Dan Girardi said that he experienced concussion symptoms during Game 1 against Pittsburgh.
Dan Girardi will be on the Rangers' third pairing during Saturday's Game 5 against Pittsburgh.
Dan Girardi is on the ice Saturday afternoon ahead of Game 5 against Pittsburgh.
Dan Girardi (undisclosed) participated in Friday's practice.
Dan Girardi (undisclosed) has been ruled out for Game 4 on Thursday.


ONE of the world's biggest cycling races could come to Ireland next year.
The Giro d'Italia -- won by Dublin cyclist Stephen Roche in 1987 -- is the subject of a bid by the Northern Irish Tourism Board as well Transport Minister Leo Varadkar's department and Failte Ireland.
The proposal is to start the three-week race in Belfast, with one of the first stages going to Dublin. If successful, it could mean a €7m windfall.
It would also give the public here to get up close to names such as Tour de France winner Bradley Wiggins.
In 1998, the Tour de France came to Ireland, but was tainted by a doping scandal. Days before the start, an assistant with the Festina team was caught with steroids and EPO.
The 1998 tour began in Dublin with an individual time trial and was followed by stages in Dublin and from Enniscorthy to Cork.
The French newspaper L'Equipe has reported that Belfast was set to be the start city for the 2014 Giro. The race was then expected to head south of the border, with a stage to Dublin.
Belfast city council is understood to be putting in £400,000 (€466,000).
It is expected that the Giro's start, known as the Grande Partenza, would take place over the bank holiday weekend of May 2 to 4.
The official start usually takes in six days, with a three-day festival followed by the first three stages of the race proper.


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At least two dealers are interested in buying stores from the bankrupt Chevrolet dealership group Bill Heard Enterprises Inc., the companys lawyer said today.
In addition, the dealership group is getting more help from another of its floorplan financing companies to pay for the wind-down and liquidation of its dealerships.
Alphera Financial Services, a division of BMW Financial Service North America, has agreed to lend Heard Enterprises $1.25 million for the three Chevrolet dealerships whose vehicle inventory it financed. The dealerships are in Plant City, Fla.; Union City, Ga.; and Sugar Land, Texas.
Judge Jack Caddell of the U.S. Bankruptcy Court approved the agreement between Alphera and Heard Enterprises today in an emergency hearing teleconferenced from Caddells Decatur, Ala., courtroom.
Robert Rubin, an attorney representing Heard Enterprises, said the agreement is almost identical to the one between Heard Enterprises and GMAC LLC that the judge approved Monday, Sept. 29. Rubin is with the Birmingham, Ala., law firm Burr & Forman.
GMAC has agreed to lend Heard Enterprises as much as $5.4 million to wind down and liquidate the 10 dealerships where it provided floorplan financing.
On Monday, attorneys for Heard Enterprises said they expected to reach agreements with all three floorplan financing companies this week. The only one remaining is JPMorgan Chase Bank, which provided floorplanning to Heards Scottsdale, Ariz., dealership. An attorney representing JPMorgan Chase participated in the teleconferenced hearing today but did not say when an agreement might be coming.
The Scottsdale dealership closed Sept. 12. The 13 other stores closed Sept. 24. Heard Enterprises filed for Chapter 11 bankruptcy Sunday, Sept. 28.
Rubin told the judge that Heard Enterprises would be unable to wind down and liquidate the three dealerships without the money being provided by Alphera.
Over the last two days, I have gotten a substantial number of calls from a substantial number of dealers across the country who have expressed interest in buying these dealerships, he said. I just got off the phone with two this morning.
As part of its agreement, GMAC said it is willing to give Bill Heard Enterprises a $1.58 million advance to pay outstanding medical claims for the portion of the 2,700 employees who had their insurance through the dealership company. But to get the money, Bill Heard Enterprises must agree to sell eight of its stores by Oct. 14 and have the judges approval for those sales.
Turnaround consultant hired
The dismantling of the bankrupt dealership group will be headed largely by a consultant who once helped liquidate the assets of convicted WorldCom Inc. founder Bernard J. Ebbers.
Fred Caruso, 53, vice president of the Chicago turnaround consulting firm Development Specialists Inc., will lead the wind-down and sale of Heards 14 Chevrolet dealerships in seven states.
According to documents filed this week the case, Bill Heard Enterprises hired Caruso on Aug. 25 to help with the financial restructuring of the company and its subsidiaries. Four days earlier, GMAC had suspended its floorplanning line of credit to the 10 Heard dealerships for which it financed inventory.
Robert Rubin, Heard Enterprises attorney, said it was Caruso who discovered the distress that precipitated the closing of Heards Scottsdale, Ariz., dealership on Sept. 12 and his 13 remaining stores Sept. 24.
Caruso, a certified public accountant, originally joined Development Specialists in 1982. Over the years, he has assumed day-to-day management control of 12 companies. He also has consulted debtors and creditors in a variety of businesses, including original-equipment and aftermarket automotive suppliers.
In 1997, Caruso was hired as COO of Mercury Finance Co., a 285-branch subprime auto lender, after the discovery of fraud at the Lake Forest, Ill., company. Caruso reduced the companys debt by $400 million by closing branches and selling noncore assets, according to his resume. An internal reorganization plan paying off all creditors in full was confirmed in early 1999.
Later, Caruso was chief restructuring officer at auto supplier Breed Technologies Inc., a maker of airbags, seat belts and steering wheels. He crafted a plan that canceled outstanding debt from the companys largest creditors -- a group of about 40 banks -- and gave those lenders stock worth 100 percent of a new Breed.
Caruso is technically an employee of Bill Heard Enterprises, which continues to exist as a debtor in possession under the U.S. Bankruptcy Code. His salary is being paid from $815,000 set aside for senior managers who are assisting in the wind-down and for security to guard the dealerships remaining inventory.


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The Department of Energy Solar Energy Technologies Office announced it selected the University of Arizona to develop a new method for identifying defects in perovskite solar cell development during the manufacturing process.
Perovskites are actively being researched worldwide for their ability to be manufactured at scale as readily printable materials that can be deposited as paper-thin solar cells. The flexible, lightweight cells are hailed for their numerous uses, like on low-load roofs, in aviation, wearables, and rapid delivery and rollout in disaster situations. Perovskites are naturally occurring minerals, but they also represent lab-made crystalline structured materials that imitate the natural minerals’ shape.
Perovskites have made leaps and bounds in their efficiency, growing from 3% in 2009 to over 25% today. However, the material currently struggles with stability, in part because temperature sensitivity causes them to degrade relatively rapidly. The earliest perovskites worked for only a few minutes or hours, but today they have a lifespan of several months. Improving this lifecycle is the focus of the grant-funded research at the University of Arizona, which is led by associate professor of chemical and environmental engineering Erin Ratcliff.
“Perovskites are the highest-performing printable solar cell technology,” said Ratcliff. “But the operating hypothesis in the field is that defects are contributing to instability.”
Ratcliff is developing a method to detect the creation of defects not after the perovskites are made, which is the traditional operation, but rather during the manufacturing process.
“What our project is about is trying to develop an in-line characterization tool to get you a quality control assessment to tell you how good the layers are in the exact moments you’re making them,” said Ratcliff. “This quality control method is also an indication for the long-term stability of the materials you’re making.”
Ratcliff is developing an electrochemical method to achieve this goal. The method can offer a more nuanced look at the potential presence of defects. It will involve using a robotic arm to apply a thin material about the thickness of plastic kitchen wrap to the solar panel being manufactured.
“You stick it on there and you apply an electric field on [the manufacturing] line, and you can figure out how it works under operation, without having to make the whole device first,” she said.
The research is supported by the Department of Energy, the Office of Naval Research, and Tech Launch Arizona, the University of Arizona’s office that commercializes research projects.
“Large-scale manufacturing of these robust, high-quality perovskite-based photovoltaics will require low-cost and practical quality control methods that can be integrated into an operating line,” said Laura Silva, senior licensing manager for the College of Science at Tech Launch Arizona. “Ratcliff’s approach is overcoming these challenges and making the technology much more attractive in a marketplace that’s demanding higher and higher performance.”
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domain: chemistry


text: I see amnesty as possible if this time around it can successfully address the issue of illegal immigration. The mistake with the 1986 Reagan amnesty legislation is that it failed to stem the flow of illegals at the border. But if we support a new American Birthright Amendment, that establishing an Art. II, §1, cl. 4 natural born Citizen as a person born of two US parents, as the ONLY means of acquiring US Citizenship at birth, and treat all those covered under this amnesty plan as permanent residents, meaning: they can only vote once they become naturalized US citizens, five year hence...there might be a way.

domain: law


Poland Euro Cup: A story of determination and ambition
The Euro Cup, a festivity of European football brilliance, has witnessed the rise of countless legends and the crafting of remarkable tales. Poland's trip through this admired competition is a testament to their firm determination and desire to etch their mark on the footballing world. As Euro Cup 2024 approaches, with the difficult Germany team as contenders, it's a suitable time to probe into Poland's team history.
Euro Cup: Germany hopes to fix repute before hosting Euro 2024
With the European Championship pending next year, host Germany hopes this week to start fixing the ragged reputation of its men’s national soccer side. Two World Cup flops and a poor viewing in between have taken their toll on what was a proud legacy for Germany. The four-time World Cup winner no longer raids fear among rivals. The German soccer alliance wants to change that before the nation hosts Euro Cup 2024.
Euro Cup 2024: UEFA inspires Euro Cup teams to avoid flying to reduce carbon impact
Euro Cup 2024: UEFA inspires Euro Cup teams to avoid flying to reduce carbon impact Teams at Euro 2024 will be likely to travel to group-stage games by coach or train in its place of flying, to reduce their carbon effect. European football leading body Uefa says it wants next summer's event in Germany to be the most workable European Contest of all time. Group games have been regionalised to help travel by land. Admirers will also be offered the sale of long-distance train tickets and free entree to local public passage.
Euro Cup: Best team to win Euro Cup 2024
The first two rounds of European Competition qualifying are over and four wins for World Cup finalists France have seen their chances. With Qatar in the rear-view mirror, national squads across the land have turned their attention to qualifying for the next big competition: Euro 2024, to be held in Germany. France front-runner as England joined with Germany.
Euro Cup: Germany set for the joy of Euro Cup 2024
Euro Cup: Germany set for the joy of Euro Cup 2024 Europe's best is to battle it out across 10 German arenas in summer 2024 with thrills on the pitch, sunshine in the stands and football fever certified. European football arranging body UEFA holds a European competition opposed by national teams every four years. The next edition will be held in Germany in the summer of 2024 and is called Euro 2024.
France Rugby World Cup 2023: Rugby gossip and transfers before RWC
It’s been another busy week with Rugby World Cup gossip, and we bring you top stories ahead of the weekend. New teachers in Edinburgh, Queensland, Pretoria and Suzuka. A busy week on the coaches’ front, with three places being filled. In Australia, the Queensland Reds announced that ex-London Irish head coach Les Kiss would take over from Brad Thorn at the Super Rugby side.
France Vs Namibia: France hit by injury fears ahead of RWC 2023 warm-ups
France’s planning for the upcoming Rugby World Cup has hit a hitch as flanker Francois Cros will be sidelined for their World Cup warm-up game against Scotland next month. The 29-year-old ached a mole injury during exercise in training for the game at Murrayfield on August 5. The damage has raised worries, but France’s head of performance, Thibault Giroud, is certain that it’s not a long-term issue, though Cros will be out of action for a few weeks.
Australia Vs Fiji: Same glitches as Australia faces another defeat before RWC
Finally, any affectation was made to look rather silly because Australia was second-best by some distance. A 31-point triumph did not praise New Zealand, who counted six tries without really leaving third gear and appeared to be timing their France Rugby World Cup run gorgeously. Before this Bledisloe Cup opener, played out in front of 83,994 fans, Eddie Jones suggested that the New Zealand budget would tank if the hosts won at the Melbourne Cricket Ground.
Rugby World Cup: The Latest Kits for the RWC 2023
As we move ever closer to the France Rugby World Cup and the following season, clubs and nations are releasing the latest kits. Now is the perfect time to run down the new sport shirt, for the World Cup. Some of these kits have fixed to a tried and tested design proving if it isn’t broken, don’t fix it, whereas others have pushed the limits with some splitting designs.
New Zealand Vs Uruguay: All Blacks are still not upright to win the RWC 2023
New Zealand Vs Uruguay: All Blacks are still not upright to win the RWC 2023 New Zealand rugby legend Murray Mexted is not getting passed away with New Zealand’s form and trusts they are not yet good enough to win the France Rugby World Cup. Ian Foster’s cares face off against Australia in the final round of the Rugby Championship next weekend, needing just two table points to seal the title. The All Blacks claimed a 35-20 win over the Springboks last weekend, taking their undefeated streak to nine games.
France Vs Italy: Sir Bill Beaumont approves Rugby World Cup Draw adjusts
France Vs Italy: Sir Bill Beaumont approves Rugby World Cup Draw adjusts World Rugby chairman Sir Bill Beaumont has described why the Rugby World Cup 2023 draw was made so early and that they are looking for answers for the next men’s contest in 2027. The pools were proclaimed for the 2023 contest on 14 December 2020, just under three years out from the start of the World Cup in France. World Rugby was widely criticised for holding it then, with so much time to go until the event began, and it has since proven to be an error.
England Vs Japan: Sweet stuff is banned at England RWC 2023 training camp
England players are including a self-imposed cake ban during their France Rugby World Cup exercise camp, with Lewis Ludlam saying the cost will pay off at the competition in France. Steve Borthwick’s team recently repaid from an exhausting week of heat training in 40C temperatures in Verona and are continuing to fine-tune their groundwork at their outdated Bagshot base. Borthwick will cut his 39-man group to 33 on 7 August, two days after England’s first warmup game, against Wales.


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The 2nd S3 Singapore Healthcare Simulation Conference (October 22nd-25th in Academia, Singapore) will provide Clinical Simulation Champions from across Asia and the world to network with world leaders and fellow industry insiders in the healthcare simulation industry, experience the latest in healthcare simulation technology and advanced simulation procedures, and transform the way your teams develop [...]
The 2019 SimGHOSTS USA: Miami healthcare simulation technology and operation annual event has just launched early-bird registration! Every year this event sells out of spots, so register early to take advantage of discounted pricing and first-come first-served access to the entire 60+ session agenda. Taking place July 30th through August 2nd at Florida International University’s [...]
One of Asia’s most successful medical simulation conferences, the 2019 2nd S3 Healthcare Simulation Conference takes place October 22-25th in Academia, Singapore. The co-organized leadership team has extended their call for abstracts and proposals extending the deadline just one week to April 30th! Don’t miss your chance to be part of Asia’s leading healthcare simulation [...]
More than 20 members of Jump Simulation, a part of OSF Innovation and a collaboration between OSF HealthCare and the University of Illinois College of Medicine Peoria (UICOMP), were chosen to make presentations at the 2019 International Meeting on Simulation in Healthcare (IMSH), January 26 – 30. The annual conference is the largest gathering of [...]
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domain: health


text:
The following post is this author’s opinion and does not reflect the thoughts and feelings of Fextralife as a whole nor the individual content creators associated with the site. Any link that goes outside of Fextralife are owned by their respective authors.
Dark. Bloody. Unforgiving. Guilt. All words that having meaning within Blasphemous. Do you have what it takes as the sole survivor of your order to explore the lands of Cvstodia? Perhaps, but this dark and cryptic action platformer will test your faith.
Genre: Action Platformer
Developed by: The Game Kitchen
Published by: Team 17
Release date: September 10, 2019
Platforms: PC (Reviewed), PS4, Xbox One, Switch
Price at time of review: $24.99
- Explore a Non-Linear World
- Brutal Combat and Executions
- Customize your Build
- Intense Boss Battles
- Unlock the Secrets of Cvstodia
Story and Setting
This is a dismal land, filled with fear of the divine. Filled with devotion to the Divine, fear of the Divine, and the absolute knowledge of their failures. The people of Cvstodia are held in the mercurial grip of the Miracle. While sometimes wondrous, more often than not the Miracle manifests itself in cruel and gruesome ways to the satisfaction of many.
Rarely do I come across a game that feels so utterly unique in it’s story and setting, and yet here we are. The land of Cvstodia and the story behind your actions as the Penitent One is quite unlike anything I’ve encountered before in a game. The land of Cvstodia is at once a divine and horrifying place, perhaps made all the more horrifying by how…proper…the suffering on display feels. Nothing really comes off as needless indulgence in suffering, rather it feels like it all belongs in a twisted fashion. This is helped greatly by the few NPCs you encounter not really displaying any despair or revulsion at the horrors that surround them.
To go into depth on the story would do both it and any potential players a great disservice. While I typically don’t jump aboard the anti-spoiler train, this is one instance where I do. Part of the appeal of this game is slowly watching the story unfold and trying figure out puzzle-like level design, cryptic conversations, and even more cryptic item descriptions that just make question what the heck is going on here. If one were to call this game a souls-like, then I feel it is should be for this reason. There’s a requirement to study, read and think, to decipher the story beyond a simple and basic level.
Audio and Visual
Oh my word is this game a work of art. A horrifying, bloody filled-with-suffering work of art to be fair, but still a work of art. If you have an appreciation for pixel art then you owe it to yourself to checkout this game. This was not an attempt to pander to pixel-nostalgia, but rather a deliberate artistic choice. The grittyness of the pixels helps to amplify the gritty nature of this world you find yourself exploring.
Every area of the game has such a unique appearance to it that after playing through the game once I could show you a screenshot, and you’d instantly recognize the area. In addition to the beautifully rendered background all the enemies are very all animated and (mostly) unique throughout the game. While I have my quibbles with the mechanics of some of the boss fights, all of the monstrous ones are quite the menace to behold. Even the humanoid ones are very well animated, though I must profess a preference for the more monstrous foes.
As for the audio, it is solid, the sound track is good and adds to the experience. I’m actually listening to the soundtrack as I work on this review, which is something I don’t do for every game. Most certainly not the best soundtrack I’ve ever heard, but it like the visuals it is unique and sounds like it belongs here. The sound effects are solid and well done with not much else to say on that front.
Now I come to the point where I stop proclaiming the game’s virtues and start lamenting its flaws. This is not to say the game is bad, but like the citizens of Cvstodia the gameplay carries the guilt of sins. The greatest of these sins, and the one most likely to induce controller-throwing rage, is the platforming. Oh, the freaking platforming.
Now since this game is billed as an action platformer saying the platforming is bad is a bit of a problem, a rather large one, actually. Thankfully I think it something that can be fixed with patches. Scattered through the world are instant death pits and spike traps. The pits have a solution late in the game, the spikes do not. The main issue is with the spikes is that sometimes the spikes are so close to the floor you can’t do a last-second ledge grab to save yourself. Sometimes there’s other traps that will trigger a massive knockback if they so much as clip you. Sometimes there’s enemies that will trigger massive knockbacks if they so much as clip you. From time to time the jumps are just so freaking precise that if you jump a fraction of a second to late or to early, and you die. The vast majority of my frustration came from dealing with the freaking spikes.
Other than the instant death parts and some quibbles with boss design, the gameplay on display is rock-solid action platformer in the vein of the Castlevania series. Enemy design is quite varied and their attacks well telegraphed so most of the time when I died I knew it was my fault. There were a few occasions where the enemy placement was such that I got juggled for obscene amounts of damage before I could recover, but these unfair deaths didn’t happen too often.
Boss fights is another area where the game shoulders the guilt of poor mechanics in the form of inconsistency. Some bosses are well balanced, taking a few tries to get a feel for their mechanics before you can beat them. Some bosses are on the hard side, feeling like they take a bit too much luck to beat. And then there’s the bosses that I despise because of either extremely poor arena design or seemingly excessive randomness. Nothing insurmountable, but it does feel like a shame that I can’t really look forward to the promised boss-rush mode since it means I’ll have to fight those two again. Bleh.
Replayability is a hard one to address as at the moment there isn’t much reason to play more than once. You can get both endings in one play through if you’re careful and regardless of the path you take on some of the sidequests, you can still get all the items in the game. Assuming your game doesn’t bug out on you, which is a problem at the moment. There is a small speedrun achievement, of course with a gameplay timer you can try and speedrun the whole game, but beyond that there’s not much. A New Game+ mode and harder difficulties are promised, but they do not exist yet.
On my main game file I have 16 hours and 99% completion. Depending on skill and how much your explore you could probably complete the game in 10 hours. At a $25 USD price-point, I think this is well worth the money assuming you are into platformers. The $38 USD Digital Deluxe edition is a bit iffier, while the sound track is good, I’ve never been a fan of digital art books and the comic is rather short so I’m not sure it’s worth the extra money.
This is a dark, challenging game. Death, violence, even self-harm is front and center here, but nothing feels gratuitous, this is simply how the world is. Combine this with beautiful yet grotesque art, some excellent level design (with the exception of the spikes, and no, I will not shut-up about the spikes.) and solid gameplay, you have a good game. So assuage your guilt and seek to understand the land of Cvstodia and The Miracle.
Blasphemous is available to play on Steam, on Xbox One and Playstation 4.
Summary: Blasphemous is a mostly solid action platformer. Beautiful yet grotesque artwork and fun moment-to-moment gameplay is held back by a few instances of badly flawed level design and some questionable boss mechanics. If you can get past the flaws there's a lot to enjoy here for fans of platformers and for lore hounds that enjoy teasing out meaning from a cryptic story
Story and Setting
Audio and Visual

domain: game


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It was the president of MCA (Geffen) Records who first noticed Ametria Dock's unique vocal talent as an Atlanta-based high school student. After signing her first record deal, Dock kicked off her music career with the release of a national debut album entitled, "It's Not About Me." By the age of 18, Ametria had already worked with some of the music industry’s heavy-hitters, like Mary J. Blige, Montel Jordan, K-Ci & Jojo, and Boyz II Mens’ Wanya Morris.
In 2003, Ametria was reintroduced to audiences as an impressive part of the vocal backdrop of multi Grammy Award winning artist, India.Arie. Her international attention has earned her an even bigger buzz among live music fans. Ametria's distinct, alto sound consistently stands out across the world on stages in Australia, Japan, London, Paris, Germany, Norway, Sweden, Denmark, and South Africa. Ametria’s vocal expertise has kept her sharing the stage with super-icons like Stevie Wonder, John Legend, Robin Thicke, Musiq Soulchild, Laura Izibor, Estelle, Wynonna Judd, and most recently, President Barack Obama. She has also lent her vocal talents to country legend Lyle Lovett (on tour), and has worked with super-producer Shannon Sanders and The Band of Horses.
Over the years, Ametria’s experience as a major artist and backup vocalist for international artists has tucked her in the background on national television programs such as, Good Morning America, The Oprah Winfrey Show, David Letterman, Jay Leno, Bobby Jones Gospel, Regis and Kelly, The Monique Show, and The Tyra Show. In addition, Dock has earned writing credits on projects for Angie Stone and vocal arrangements for India.Arie. Working with blues singer Jonny Lang and Reggae artist Gramps Morgan of Morgan Heritage, Ametria has developed an ear for singing and teaching a broad span of genres ranging from Bluegrass, to Pop, R&B, Country, Rock and Reggae.
As a professional vocal coach, Ametria has served as a reliable musical consultant for several commercial artists, proficiently helping them to continue to develop and maximize their vocal talent. With clients like Janelle Monae, India.Arie, Anthony David, new soul sensation Avery Sunshine, and Reggae artist Gramps Morgan, she continues to use her wide range of musical experience (both on stage and in the studio) to effectively teach various techniques and styles. Her efforts help to increase the stage confidence and overall vocal competence of singers, helping them find and highlight their best voice. Ametria Dock continues to be a trusted source for vocalists on various levels who are seeking guidance and tutelage.


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Sermons on Bible History (Page 2)
Bible History (informative, historical, allegorical)
Dave Dulaney Jr.
In the different stages of Judah’s strength, they are compared to a lion cub, a full grown lion, and a nursing lioness, the fiercest of all. From now on, a lion was the standard

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Scientists discover 'jumping' genes that can protect against blood cancers
(Press-News.org) DALLAS - April 8, 2021 - New research has uncovered a surprising role for so-called "jumping" genes that are a source of genetic mutations responsible for a number of human diseases. In the new study from Children's Medical Center Research Institute at UT Southwestern (CRI), scientists made the unexpected discovery that these DNA sequences, also known as transposons, can protect against certain blood cancers.
These findings, published in Nature Genetics, led scientists to identify a new biomarker that could help predict how patients will respond to cancer therapies and find new therapeutic targets for acute myeloid leukemia (AML), the deadliest type of blood cancer in adults and children.
Transposons are DNA sequences that can move, or jump, from one location in the genome to another when activated. Though many different classes of transposons exist, scientists in the Xu laboratory focused on a type known as long interspersed element-1 (L1) retrotransposons. L1 sequences work by copying and then pasting themselves into different locations in the genome, which often leads to mutations that can cause diseases such as cancer. Nearly half of all cancers contain mutations caused by L1 insertion into other genes, particularly lung, colorectal, and head-and-neck cancers. The incidence of L1 mutations in blood cancers such as AML is extremely low, but the reasons why are poorly understood.
When researchers screened human AML cells to identify genes essential for cancer cell survival, they found MPP8, a known regulator of L1, to be selectively required by AML cells. Curious to understand the underlying basis of this connection, scientists in the Xu lab studied how L1 sequences were regulated in human and mouse leukemia cells. They made two key discoveries. The first was that MPP8 blocked the copying of L1 sequences in the cells that initiate AML. The second was that when the activity of L1 was turned on, it could impair the growth or survival of AML cells.
"Our initial finding was a surprise because it's been long thought that activated transposons promote cancer development by generating genetic mutations. We found it was the opposite for blood cancers, and that decreased L1 activity was associated with worse clinical outcomes and therapy resistance in patients," says Jian Xu, Ph.D., associate professor in CRI and senior author of the study.
MPP8 thus suppressed L1 in order to safeguard the cancer cell genome and allow AML-initiating cells to survive and proliferate. Cancer cells, just like healthy cells, need to maintain a stable genome to replicate. Too many mutations, like those created by L1 activity, can impair the replication of cancer cells. Researchers found L1 activation led to genome instability, which in turn activated a DNA damage response that triggered cell death or eliminated the cell's ability to replicate itself. Xu believes this discovery may provide a mechanistic explanation for the unusual sensitivity of myeloid leukemia cells to DNA damage-inducing therapies that are currently used to treat patients.
"Our discovery that L1 activation can suppress the survival of certain blood cancers opens up the possibility of using it as a prognostic biomarker, and possibly leveraging its activity to target cancer cells without affecting normal cells," says Xu.
Xu is an associate professor of pediatrics at UT Southwestern and a Cancer Prevention and Research Institute of Texas (CPRIT) Scholar in Cancer Research. Lead authors from the Xu lab include Zhimin Gu and Yuxuan Liu. Other collaborators include John Abrams and Alec Zhang from UT Southwestern, and Wenfeng An from South Dakota State University.
This work was supported by the National Institutes of Health (R01CA230631 and R01DK111430), CPRIT (RR140025, RP180504, RP180826 and RP190417), a Leukemia & Lymphoma Society Scholar award, an American Society of Hematology Scholar award, a Leukemia Texas Foundation research award, a Welch Foundation grant (I-1942), and donors to the Children's Medical Center Foundation.
Children's Medical Center Research Institute at UT Southwestern (CRI) is a joint venture of UT Southwestern Medical Center and Children's Medical Center Dallas, the flagship hospital of Children's Health. CRI's mission is to perform transformative biomedical research to better understand the biological basis of disease. Located in Dallas, Texas, CRI is home to interdisciplinary groups of scientists and physicians pursuing research at the interface of regenerative medicine, cancer biology and metabolism. For more information, visit: END
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[Press-News.org] Scientists discover 'jumping' genes that can protect against blood cancers


text: Hi everyone I am still fairly new here and learning my way around even though I have been here before. I am a big fan of the WOT series and looking forward to the TV series. I love fantasy and science fiction books and discovered the WOT series quite some time ago and been a fan ever since. This is my 2nd time trying to finish (more on that later) anyway last time I made it to book 4 or 5 and started with A New Spring, now I am reading Winter's Heart. I am doing my best to avoid spoilers but have so many questions. I am looking forward to chatting about the series and learning from many here in the White Tower.


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Limited edition Iron Man 3 bust coming in September 2013!
Limited edition 1/4 Scale bust from IRON MAN 3.
Check out Hot Toys’ 1:6 scale figure of the Iron Man Mark XLII suit from Shane Black’s Iron Man 3. Limited edition item (number TBA). Release date: May 2013. Forms a part of Hot Toys’ new line of poseable figures – the “Power Pose Series”. Power Pose Series figures display perfectly with Hot Toys’ Movie Masterpiece and […]
SDDC 2011 exclusive with 8 Avengers statues!
Another awesome Hot Toys Movie Masterpiece figure!


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Enjoy enviable views over the coastline and nearby Hartlepool Marina when you dine in this unique rooftop restaurant at the Hill Carter Hotel. The exciting new menu is equally as spectacular where aficionados of fresh fish will be spoilt for choice. Infamous in the North East restaurant circuit, Lee Pennick is the charismatic chef-proprietor who is always pleased to see you. Indulge in a pre or after dinner drink on the leather sofas in the comfortable lounge area to make the most of your dining experience.
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Satellite Compass Systems
Fremantle Marine Electronics have been installing and commissioning satellite compass systems on vessels for many years for use in survey, fishing, and recreation vessels. Satellite compass systems offer the benefits of stable, accurate heading & vessel motion data regardless of vessel type (steel, aluminium, fibreglass). The motion data is mostly used to remove 'waves' from the echosounder picture - some manufacturers call this 'stabilisation' or heave compensation. Many WASSP multibeam systems, and single beam sounders like the FURUNO FCV-1150/1900 or KODEN CVS-FX2/70X benefit from a high accuracy satellite compass to remove any heave and pitch/roll from the echo-sounder picture.
A satellite compass can also be connected to a RADAR to give a 'stabilised' radar image, and to allow radar/chart overlay functions. It can also be used to provide a relaible, high accuracy heading for an autopilot.
Integrated all in one designs like the FURUNO SC30/70 offer relative high heading accuracy (1.0 / 0.4 degrees accuracy) for a small size antenna. These cannot offer different GPS constellations, and cannot offer DGPS (RTK). For most fishing vessels these are a perfect fit.
Separated antenna design like the FURUNO SC-130 are generally used on larger vessels as they have a much larger footprint, as a result this model also offers much higher heading accuracy but cannot offer high accuracy DGPS.
High accuracy separated antenna design like the TRIMBLE SPS 461, or the FUGRO V113 or similar offer high position accuracy of approx 0.5mtr RMS without corrections. With RTK corrections applied, real life position accuracy of 0.8CM is possible!
Fremantle Marine Electronics can offer satellite compass systems to interface new or existing Furuno, KODEN, GARMIN installations, WASSP Multibeam, sounders, autopilots, and radars. These are available in either NMEA2K, CAN-BUS, ETHERNET, or NMEA0183 versions with very competitive prices.
TRIMBLE Integrated GPS and ATEC/OLEX
High accuracy Trimble satellite compass on a wide angle multibeam sounder produces clear images in almost any sea-state.
FURUNO SC70 and FCV-1900
Furuno FCV-1900 sounder with SC-70 for heave compensation provides a very clear seafloor image.


The Pinagkaisang Samahan ng Mga Tsuper at Operator Nationwide (Piston) – Cebu chapter said it will join a nationwide protest-rallies on Monday and Tuesday against the government’s plan to phase out old jeepneys but only for half-a-day.
Greg Perez, Piston–Cebu coordinator, said on Monday they will also ask for a dialogue with officials of the Land Transportation Franchising and Regulatory Board (LTFRB) in Region 7 since they were not given a chance to air their side on the transport modernization plan.
He said they are not against the modernization plan but the jeepney operators and drivers in Cebu also want to regulate some routes in order not to obstruct the flow of the traffic, among others.
Joining the group’s rally are tricycle drivers who claim to also be affected by the modernization program and several concerned groups.
Cebu City and other local government units in the province will deploy shuttle buses for passengers who will be affected by the transport strike. A police officer will be assigned to board the shuttle buses.
No classes in Albay
Meanwhile, Albay Gov. Al Francis Bichara ordered the suspension of classes in all levels, both private and public, on Monday and Tuesday with the impending mass transport strike by local transport group.
“In view of the impending mass transport strike on December 4-5, 2017 by the transport sector and in order to maintain peace and order and public safety, the PDRRMC [Provincial Disaster Risk Reduction and Management Council] orders the suspension of classes in all level except in the island barangays and areas,” the governor said in his directive.
The order does not cover those schools located in the island barangay (villages).
However, there is no suspension of work in private and government offices.
Bichara suggested that early marketing and buying of food stuffs, medicines and other errands must be done and the public is advised to avoid unnecessary movements until the public transport system in the province resumes.
He also ordered ambulances of all local government units to be on standby to assist emergency cases within their respective areas.
with RHAYDZ B. BARCIA


Benjamin S. Jordan is the Manufacturing Manager for Centrus Energy’s Technology and Manufacturing Center. In this position Mr. Jordan is responsible for ~$50M+ of precision manufacturing equipment including 50 precision CNC machine tools as well as the associated inspection and certification equipment. Mr. Jordan is also responsible for business development in this role.
From 2011 to 2015 Mr. Jordan served as the Demonstration Facility Operations Manager for Centrus Energy’s K-1600 Test Facility. In this capacity, he was responsible for the Test Engineering, Operations, and Maintenance required to maintain and operate the full-scale test centrifuges used in the American Centrifuge Program.
From 2009 to 2011 Mr. Jordan served as the Design Engineering and Analysis Manager. The responsibilities of this position included management of USEC’s design engineers, who produced the design drawings for the centrifuge machines, as well as the direction of the analysts who used various analysis tools to validate design characteristics and predict outcomes of design modifications. Additionally, Mr. Jordan provided the final signature approval for the mechanical drawings and technical reports produced by the program.
Beginning in 2005, Mr. Jordan served as the Manager of USEC’s Manufacturing Development and Integration group. In this capacity, he was responsible for the on-time delivery and high quality construction of components necessary for the development and demonstration of USEC’s American Centrifuge. He was responsible for leading the team that provided the hardware necessary to build the first Lead Cascade of machines to operate at the American Centrifuge Plant in Piketon, as well as the hardware for the machines used at the K-1600 Test Facility to demonstrate “Target Performance”.
Upon joining USEC in 2003, Mr. Jordan served as the Integrated Product Team Leader for both the Upper Suspension and Column subassemblies. After resolving design challenges associated with these subassemblies, he delivered 66 of each to the American Centrifuge Plant in Piketon on time and within budget. Before coming to USEC, Mr. Jordan performed a variety of engineering and supervisory roles in auto parts manufacturing facilities. Early in his career, Mr. Jordan operated and then sold a business which held rights to a patented technology, which he and several partners developed, to provide deceleration sensitive flashing brake lights.
Mr. Jordan has a Masters of Mechanical Engineering and a Master of Business Administration from the University of Tennessee in Knoxville. He has obtained certification as a Project Management Professional and is a Derivative Classifier of Centrifuge information.