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New York, Feb 7 : Scientists have developed a CRISPR gene-editing technique that can potentially correct a majority of the 3,000 mutations that cause Duchenne muscular dystrophy (DMD), a genetic disorder characterised by progressive muscular weakness.
The method, detailed in the journal Science Advances, works by making a single cut at strategic points along the patient's DNA.
The method, successfully tested in heart muscle cells from patients, offers an efficient alternative to the daunting task of developing an individualised molecular treatment for each gene mutation that causes DMD.
It also opens up possible new treatment approaches for other diseases that have thus far required more intrusive methods to correct single-gene mutations.
"This is a significant step," said Eric Olson of University of Texas Southwestern Medical Center in the US.
"We're hopeful this technique will eventually alleviate pain and suffering, perhaps even save the lives, of DMD patients who have a wide range of mutations and, unfortunately, have had no other treatment options to eliminate the underlying cause of the disease," Olson said.
The new strategy can enhance the accuracy for surgical-like editing of the human genome, correcting mistakes in the DNA sequence that cause devastating diseases like DMD.
DMD is a rare disease affecting primarily boys and is caused by defects in the gene that makes the dystrophin protein.
Normally, the dystrophin protein helps strengthen muscle fibers.
The new study demonstrated how a wide range of mutations can be corrected in human cells by eliminating abnormal splice sites in the genomic DNA.
These splice sites instruct the genetic machinery to build abnormal dystrophin molecules, but once the gene is successfully edited it expresses a much-improved dystrophin protein product, enhancing the function of the muscle tissue.
"In fact, we found that correcting less than half of the cardiomyocytes (heart muscle cells) was enough to rescue cardiac function to near-normal levels in human-engineered heart tissue," said Chengzu Long, lead author of the study and Assistant Professor of Medicine at New York University Langone Health.


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One of Rap’s most slept on wordsmiths is linking with younger talent. Lupe Fiasco is prepping a new release manned by Kaelin Ellis.
The Chicago MC and the Orlando producer have announced their collaborative EP HOUSE, out on July 24th. The announcement comes with the first single from the EP “SHOES” featuring Virgil Abloh. The HOUSE EP came together by chance — on May 5th, Lupe was tagged on Twitter in the replies of a Tweet from Kaelin Ellis, a young producer who had been posting clips of himself creating beats in lockdown.
Reading “Get this to @LupeFiasco somehow,” Lupe listened, liked the beat, screen recorded Kaelin’s video, dropped it in GarageBand, freestyled over the beat, exported it in Quicktime, then Tweeted the song just a few hours after he first saw the mention.The two then began interacting over Twitter, Kaelin sending beats to Lupe, who rapped over the tracks he liked. A few weeks later they had a 5 song EP titled HOUSE, referencing that the two had created the collaborative EP locked down in their respective homes.
For the EP’s first track “HOMME MADE,” Lupe had his friend Virgil Abloh speak about the concept of a house — Virgil has a Master of Architecture, and Lupe wanted to present an architect’s perspective. Abloh is also featured on the song “SHOES,” where he describes hypothetically designing the shoes that Ahmaud Arbery was wearing when he was murdered.
You can listen to “SHOES” here.
Photo: Nikki Nelson/WENN.com

domain: entertainment


text:
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domain: sociology


PLEASANTVILLE, N.Y. -- Here's what's coming up at The Jacob Burns Film Center:
"The Place Beyond the Pines," starring Ryan Gosling and Eva Mendes, opens Friday, April 12.
"Renoir ," a story of the celebrated Impressionist painter and his son, continues this week.
The 12th annual Westchester Jewish Film Festival continues through April with 15 programs including "Süskind," "The Law in These Parts," "Inventing Our Life: The Kibbutz Experiment," "The Day I Saw Your Heart" and "Yossi." On Friday, April 12 at 7:15 p.m. there will be a Q&A with Author Bryce Renninger, Author & Activist Jayson Littman, JBFC Programmer Karen Sloe Goodman and JBFC Valentine and Clark Emerging Artist Fellow Daniel Sitts.
Additional screenings of " Koch" are playing this week.
Join the center for An Evening with Steve Apkon and His New Book, "The Age of the Image," followed by a book signing and reception upstairs in the Jane Peck Gallery on Monday, April 15 at 7:15 p.m. All ticketholders will receive a signed copy of "The Age of the Image: Redefining Literacy in a World of Screens."
For more detailed information, click here to read the entire E-Bulletin.
Click here to sign up for Daily Voice's free daily emails and news alerts.


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County Prosecutor Uses Message-Deleting App — “Fairfax County Commonwealth Attorney Steve Descano is using an app called Signal which deletes text messages like Snapchat…Descano is using the Signal app to avoid written communication from being obtained by the public and the press as allowed under the Freedom of Information Act, according to sources close to Descano.” [ABC7]
Hyundai and Kia Vehicles Targeted for Thefts — “On Jan. 14, officers responded to numerous calls for service involving stolen or damaged vehicles in Lorton. The thieves appeared to target Hyundai and Kia vehicles…The increase in calls for service regarding stolen and damaged vehicles is consistent with a pattern seen throughout the county.” [FCPD]
Youngkin Seeks to Require Merit Commendation Notices — “In response to widening concerns about how some northern Virginia school districts handled recognizing student achievements on a standardized test, Gov. Glenn Youngkin called Wednesday for legislation to require student and parental notification about certain scholastic awards.” [Associated Press/WTOP]
Deal Closed on Fairfax City Supportive Housing Site — “We closed on our property at the Hy-Way Motel! It’s the future home of our Permanent Supportive Housing development and we could not be more excited! Over the next few days, you’ll see some changes with the building beginning with a fence around the hotel and demolition in the next couple of months.” [The Lamb Center/Facebook]
Mount Vernon Rec Center Renovation Breaks Ground — “A groundbreaking ceremony was held on Wednesday, Jan. 18, 2023, for the expansion and renovation of the Mount Vernon Rec Center in Alexandria, Virginia, one of the county’s oldest and most popular Rec Centers.” [Fairfax County Park Authority]
Local Slug Lines See Drop in Popularity — “Three years into the pandemic, the once-popular slug lines along Interstate 95 are still ailing…On a recent morning, the site of the region’s oldest slug line — Bob’s Slug Line off Old Keene Mill Road in Springfield — was sleepy. Unlike in the old days, there were no lines of passengers waiting and no drivers shouting their destination.” [The Washington Post]
Capital Projects Website Gets Update — The Fairfax County Department of Public Works and Environmental Services (DPWES) has updated its website on capital projects with “a new look and improved functionality.” Changes include a simpler homepage, a central page for all projects, and new search options for finding bids and solicitations. [DPWES]
McLean Community Center Board Election Begins — Petition packets are now available through March 3 for candidates seeking to join the governing board. Candidates must be residents of Small District 1A and obtain 10 signatures endorsing them. There will be three adult seats and two youth seats up for grabs in this year’s election, which will have voting from March 15 through McLean Day on May 20. [MCC]
Mason Neck Park Considers Accessibility Improvements — “At present, there are no accessible paths leading from the parking lot to the play structure or picnic table. Sections of the asphalt trail have buckled from roots growing underneath, and the path’s incline and decline can be challenging for wheelchair users to navigate. Mason Neck Park Manager Lance Elzie is on a mission to change that.” [On the MoVe]
It’s Thursday — Rain until evening. High of 54 and low of 39. Sunrise at 7:25 am and sunset at 5:16 pm. [Weather.gov]
Good Friday evening, Fairfax County. Let’s take a look back at today’s stories and a look forward to tomorrow’s event calendar. 🕗 News recap The following articles were published earlier…
Reston Association is seeking candidates for its 2024 Board of Directors’ election. Four seats are open for the election, which will take place in March. Specifically, two at-large director seats…
Zombies, pirates and other virtual characters are about to be unleashed on Tysons, just in time for Christmas. Sandbox VR will launch its new virtual reality gaming experience at 1656…
Do the holidays have you stressed and busy? Worry not about what to wear as Live Fairfax has the Style Survival Guide for this season!
The Georgetown Visitation Masqueraders proudly present
Descendants The Musical
Art House 7 warmly welcomes you to our upcoming Fall 2 session of classes starting on October 30th. We’re thrilled to offer a diverse range of mediums and flexible class lengths, catering to a wide age range, starting from as young as 2, and, of course, providing a multitude of engaging options for adults!
Our classes cover an exciting spectrum of creative mediums, including fiber arts such as knitting, modern embroidery, crochet, and sewing. We also offer classes in ceramics on the wheel, drawing, watercolor, gouache, oil, acrylic, still-life painting, and captivating Japanese Suminagashi and printmaking. One of the highlights of this session is the highly anticipated 5-week “Painting the Portrait and Figure” workshop, led by the renowned local artist, Danni Dawson.
For our younger artists, we have specially designed classes like “Art Exploration through Impressionism” for students in kindergarten through 5th grade, an engaging “Art Together” parent-child class designed for 2–4-year-olds, and a “Teen Taught Art Club” tailored for kindergarteners through 4th graders.
Proceeds benefit Fellowship Square, improving the lives of 800+ older adults with very limited income and resources by providing affordable housing and supportive services.
Experience a festive holiday fundraiser complete with savory wines & craft beers, scrumptious hors d’oeuvres, exciting

domain: news


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1 cup all purpose flour (4 ½ ounces)
½ cup unsalted butter, chilled (4 ounces)
1½ teaspoon sugar
1/8 teaspoon kosher salt
¼ cup cold water
8 ounces (half-pint) Low-Sugar White Peach Compote with SIMI Sonoma County Dry Rosé*
1) Cut the butter into small pieces, and put it in the freezer for 10 minutes. Measure out the water, and place it in the freezer until ready.
2) Mix the flour, ½ teaspoon sugar and salt in a bowl. Add half the butter. Using quick, light movements, work it in with your fingers until the texture resembles cornmeal. Work in the remaining butter, leaving pea-sized bits. Add the ice water all at once—you want just enough moisture to hold the dough together. Gather the dough into a ball and wrap it in plastic. Flatten it into a disk and refrigerate for half an hour. Heat the oven to 375 degrees.
3) Roll out the dough in a 12” circle and dust it well with flour. Wrap the dough around the rolling pin and transfer it to a baking pan lined with parchment paper. Generously sprinkle the dough with more flour. Starting at the middle of the dough, spread the jam into a thick layer, leaving a 2-inch margin at the edge. Fold the edges back towards the center. Sprinkle the remaining sugar over the crust.
4) Bake for 40 to 45 minutes until the crust is golden and the jam lightly caramelized. Cool on a rack and serve at room temperature with crème fraiche.
*Store-bought peach compote or jam (or any compote flavor you prefer) can be used here

domain: food


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Want to disrupt a relationship or marital bliss? Ask your fiancé or spouse – or that of your child planning their wedding – to present their loved one with a pre-nuptial or their spouse with post-nuptial agreement.
Whether called a prenuptial agreement, antenuptial agreement or premarital agreement, or a postnuptial agreement, if signed after the marriage or civil union, clearly lay out who gets what property or proceeds in the event of divorce or death.
They’re not inherently toxic to living happily ever after. In fact, they can play an important role in protecting assets and relationships. We previously wrote about expecting the unexpected, and the impact death, divorce and other calamities can have on life and family business.
Some patriarchs and matriarchs of high-net-worth families who have put in place family governance and planning look to protect their family assets by asking their children discuss a prenup with their fiancés. “Get this signed to protect the family,” the thinking goes.
The implication for some also reads, “get this signed, or be cut off.” For their part, the children often are petrified to present the documents, for fear of being perceived as injecting doubt about their commitment or inviting the ire of their parents if they refuse. Any discussion of trust or the relationship being about true love, becomes suspect.
The reality is that prenuptial agreements can be in the interest of both parties. If one fiancé or spouse has or brings significant means to the relationship, the agreement will protect those assets. It also can indicate an understanding of the dynamics at work, while also proving the other has no designs on the family assets. Regardless of what assets may be expected in case of divorce or death, they are codified in the agreement.
This isn’t just about rich versus not-so-rich. Pre- and post-nuptials also can protect couples of modest means, especially if one is a higher earner, or the other gives up a career to raise a family. Who gets what in the event of divorce can be spelled out in the agreement. Post-nuptials can be especially helpful if no will or trust is in place. Most importantly, it reduces the chance of conflict around their couple’s children in the case of divorce.
These don’t just protect young love gone awry. In January of this year, we wrote about the risks of grey divorce and in March, The American Bar Association also reviewed the subject in an article. Whilst in general the divorce rate has been dropping, the over 50’s account for a quarter of all divorces; the over 65’s represent 10%. Older Generation Xers and Baby Boomers may also have reason to reassess their interests, especially if they came into money later in life.
For families with international lifestyles, the legality of pre- and post-nuptial agreements vary country by country. I was married in Switzerland, under a prenup presented by my wife’s family. Switzerland recognises three marital regimes. Participation, community of assets and separation of assets, under some of these regimes, the State obliges a form of pre-nup written up and signed by a notary public.
Once you get beyond the perceived reputation, prenups clearly have distinct benefits. You never know where life will take you. With a prenup, regardless of wealth, the outcomes are outlined and the path clear. However, it must be stated that in some countries, inheritance is not part of assets considered in a divorce or nuptial agreement.
Matters of alimony, custody, child support and other payments are rarely that tidy and can ceaselessly clog our courts. But if the two parties treat it as a legal contract, it can ease dissolution of marriage and distribution of assets. At whatever age or stage the need arises, if one party honestly wants a pre- or post-nuptial agreement, it must be approached as an agreement amongst equals.
If this is a conversation you feel you must have, but still fear having it, a third party or mediator type person may help avoid or at least reduce any conflict or distrust. It is our opinion that the intermediary shouldn’t be hired by one party to seemingly “represent” both. They must be independent, or it can do irreparable harm to the negotiations or relationship. If both parties agree in principle to an agreement, that’s where a qualified attorney comes in, however each party should have their own counsel.
The winding road of marriage isn’t always smooth and doesn’t always end in bliss. Presented well, with mutual understanding and truly shared interests at heart, pre- or post-nuptial agreements can protect your futures and that of your children.

domain: law


It’s too early to drop the Spokane Chiefs’ playoff series with the Tri-City Americans into the epic category but it is certainly working in that direction.
After two straight overtime games, the series is heating up with the Chiefs taking a 3-2 lead into the Arena tonight for the sixth game in the best-of-7 Western Hockey League showdown.
“So far it’s been as advertised for me,” Chiefs’ general manager Tim Speltz said. “It’s been a very good series.”
It started with the Americans winning the first game in Spokane, and after the teams split two in the Arena, the Chiefs won two of three in Tri-Cities.
In Game 4 on Thursday, the Americans pulled out a 4-3 win in the second overtime, and Sunday night James Reid’s save and Blake Gal’s goal in overtime put the Chiefs back on top.
“If there is a difference, I think the goaltender that’s played the best that team has won on any given night,” Spletz said. “Other than that, there’s not a lot to separate these two teams. Both are very well prepared, both are well coached, both teams have made adjustments from game-to-game and also on the fly during games. That’s what payoffs are. If you don’t do that you get left behind and for sure no one has gotten left behind here.”
Even though the Chiefs had 2-0 leads in the second period of the past two games, Spletz said there was no reason to panic.
“I don’t think a team is going to dominate for 60 minutes. There’s not enough separation,” he said. “Any time we make a mistake they capitalize. Not necessarily with a goal, but with a penalty or a chance. They make you pay for your mistakes. Both teams are similar that way.”
The Chiefs scored in the first minute of Sunday’s game after an Americans turnover, and made it 2-0 early in the second by converting an odd-man rush. Tri-City’s first goal in the third was on a three-on-two.
Gal was penalized early in overtime and the only reason he got to score the winner 6 seconds after the penalty expired was because Reid made a glove save on Carter Ashton.
“It’s a game of mistakes,” Spletz said. “You’re going to make mistakes, but if you make a second mistake and a third, chances are it’s not going to go good for you.”
The Chiefs struggled to hold leads against Chilliwack in their first-round series, but Spletz said that was a different situation.
“It was two different series,” he explained. “The one with Tyler Johnson, we had pretty good control. Then we had a series without Tyler Johnson (injured in the third period of Game 3). We played two games and two periods with Johnny, then played two games, a period and an overtime without him. To lose a player that’s been a big part of your team, we didn’t adjust to that as well as we could have. We got through it, we won. Give credit to our guys.”
That experience is paying off. Not that balance is anything new, but the Chiefs are getting contributions throughout their lineup with 20 different players picking up a point – 14 of them with goals – in the 10 playoff games.
Gal leads in goals with six, three of them winners. Defenseman Jared Cowen has 10 points, nine on assists. Steve Kuhn has five goals and five assists. Despite missing two games, Johnson has five goals. And a pair of fourth-line wingers, Darren Kramer and Mitch Holmberg, have four goals each.
Maybe that depth can keep this series from becoming epic.
“It sure could be, but until it’s over you can’t say,” Spletz said. “When you look at it, if ‘08 wouldn’t have had Game 7, it wouldn’t have been as epic. … The drama of the ’08 series with the double overtime games made that one unique. For me, this one isn’t much different than that without the extra time.”


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With the drop in interest rates we are getting slammed with
new appraisal requests from lenders. My three lenders are very busy and they believe
that rates will stay low for a while.
I suspect that after the school year starts and the kids are
back to school borrowers will have more time to focus on re-financing their

domain: economics


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Hepatotoxicity. Fexofenadine use isn’t generally associated with liver enzyme elevations but terfenadine, another generation antihistamine that is metabolized in part to fexofenadine, was the attributed cause of several reported cases of clinically apparent liver injury.
Don’t take 2 doses together to make up for a forgotten dose click to find out more. Some antacids are able to reduce the amount of fexofenadine your body absorbs. Due to this, it’s suggested you don’t take indigestion remedies during the two hours before or even during the 2 hours after you take a fexofenadine tablet.
In general, fexofenadine takes about one hour to take effect, however, this can be influenced by the choice of dosage form together with the presence/absence of certain foods.
Conclusions. Fexofenadine demonstrated no antitussive activity against capsaicin-induced cough in healthy volunteers and subjects with URI.
Interactions between your drugs No interactions were found between Fexofenadine and Benadryl. This doesn’t always mean no interactions exist. Always check with the healthcare provider of yours.
6Stability/Shelf Life i was reading this. Commercially available fexofenadine hydrochloride capsules have an expiration date of 18 or even twenty four weeks after the date of manufacture when packaged in the manufacturer’s unopened blister packages or even high-density polyethylene bottles, respectively.
Fexofenadine is an antihistamine used to relieve allergy symptoms like watery eyes, hives, sneezing, itching eyes/nose, runny nose, and itching. It works by blocking some natural substance (histamine) that your body makes during an allergic reaction.
The 1st possible anti inflammatory effect for fexofenadine was introduced by Abdelaziz who suggested that suggest that fexofenadine may reduce nasal inflammation by modulating the release of proinflammatory mediators and adhesion molecules from human nasal epithelial cell your domain name.

domain: biology


text:
Note: Spoilers ahead for the "San Junipero" episode of "Black Mirror."
On Friday, Netflix dropped the third season of "Black Mirror," Charlie Brooker's cult dystopian anthology series. As fans already know, in the world of "Black Mirror," the future hates you and your phone will ruin your life.
But as in the past — notably in bittersweet episodes like "Be Right Back" and "The Entire History of You" — the show also has a unique flair for romance. And the new season's standout "San Junipero," a twisty love story, is its best episode to date.
Set mostly in 1987, "San Junipero" tells the story of Yorkie (Mackenzie Davis), a shy, bespectacled newcomer to the titular "party town," and Kelly (Gugu Mbatha-Raw), the dazzling young woman who sweeps her off her feet and gives her a taste of first love.
If you haven't watched the episode, stop here and go watch. If you have, watch it again. Then come back and see if you caught the very satisfying trove of clues and clever nods along the way to the story's slowly unfolding reveal — that San Junipero is a virtual reality for the dying and dead, and that Yorkie and Kelly are two old women in their last days — on this plane anyway. Let's just say the DJ at Tucker's has a wry sense of humor. Let's go:
The opening shots of the episode establish the town of San Junipero — apparently named after the "eager for souls" Catholic missionary — with a poster of the 1987 classic "The Lost Boys," about a California town full of sexy young vampires. The poster's famous tagline? "Sleep all day. Party all night. Never grow old. Never die. It's fun to be a vampire."
Yorkie first appears exiting a car playing Belinda Carlisle's '87 hit "Heaven Is a Place on Earth" — because in the "Black Mirror" world, it is.
The camera pans to a shop featuring a wall of televisions blaring Max Headroom. Though you may be familiar with the popular '80s-era character, played by Matt Frewer, did you know the character's backstory? In the original TV movie, he's a man once named Edison Carter who, after a devastating motorcycle accident, lives on as a digital version of his former self.
It also wouldn't be a stretch to imagine that series creator Brooker, who also wrote this episode, is a fan of the famous Max Headroom "incident," one of television's first and still most fascinating hacks. It just happens to have taken place in 1987.
[jwplayer file="http://media.salon.com/2016/10/10.27.16_Zepps_BlackMirror_PHONECLIP.mp4" image="http://media.salon.com/2016/10/10.27.16_Zepps_BlackMirror.png"][/jwplayer]
And Yorkie isn't catching a snippet of Headroom's TV show; it's his 1986 music video with Art of Noise, "Paranoimia." She gets to hear its opening line: "Am I dreaming? No. Where am I? In bed."
Yorkie spots Kelly and follows her into the nightclub Tucker's. The playlist at Tucker's appears to have been well-designed for a crowd that's passing through on a more ephemeral plane. Yorkie walks in to Robbie Nevil's "C'est La Vie" in time to hear Nevil sing, "Is this really what life's all about?" Throughout the episode, other songs played at or around Tucker's include "Fake," "Living in a Box," "Girlfriend in a Coma," "Ironic" and "Can't Get You Out of My Head." Sense a theme?
Yorkie beelines for the club's arcade games, takes some change out her pocket and looks at a quarter like it's a long-lost friend, and plays Bubble Bobble. A fellow clubgoer explains to her, "It's got different endings, depending on if you're one- or two-player." As she will soon learn. (Earlier this week, Vulture's Jackson McHenry persuasively argued that line can be interpreted in more than one way.)
Her new friend then tries to entice her to play Top Speed, an invitation that she — in reality, a woman who's a quadriplegic as result of a car accident that occurred more than 40 years ago — shudderingly rejects as soon as the red car in the game crashes.
Yorkie and Kelly meet when Kelly sidles next to her and enlists her in ditching her recent fling, Wes, who cryptically warns her: "Two hours, 35. There's not much time left."
"Last week was last week," she tells him. We later learn San Junipero's thrills are rationed out to visitors for just a few hours a week.
Kelly rejects Wes by saying she wants to spend time with her "friend," who only has six months to live. Yorkie replies, "Five." At first viewing of the episode, it seems like a conspiratorial lie. The second time, it sounds like an honest confession.
Kelly asks Yorkie about her glasses, which she quickly assesses are just for show. Who needs glasses in virtual reality? Kelly observes that the other people in the club "try so hard to look how they think they should look; they probably saw it in some movie," which is also logical for an alternate reality. Later, when Yorkie crosses over to permanent residency, she leaves her glasses behind on the beach.
Kelly invites Yorkie to dance, but Yorkie replies, "Dance floors aren't my thing. I can't." She then awkwardly attempts to groove — the audience doesn't yet know the real Yorkie is telling the truth when she says, "I've never been on a dance floor." She then runs outside as Alexander O'Neal sings, "You're a fake, baby," and holds her foot out in front of her — perhaps marveling at her virtual ability to do so.
Kelly comes outside after her and tells Yorkie, "Midnight's two hours away" and says, "We could be back at mine" in a finger snap. You realize later the finger snap seems a legitimate part of the offer.
A week later Yorkie gets ready to go out, in a brief montage showing her dressing like post-makeover Ally Sheedy in "The Breakfast Club" to the sounds of "Don't You Forget About Me," a video vixen to T'Pau's "Heart and Soul" and a slicked-back Robert Palmer girl to "Addicted to Love." She probably saw it in some movie.
Kelly runs into Wes, who begs to see her again, telling her, "The locals? They're like, dead people." They really are!
A guy at Tucker's tries to pick up Kelly by telling her about his kneecap surgery. Odd gambit, until you realize he's probably an old man in a bed somewhere, too. As they listen to "Living in a Box," he tells her, "I never got this song." Never, because it's from the distant past. Then he reminisces with her about how he wishes he had caught "that first wave" with computing, and looks meaningfully at his watch, knowing he's short on time.
Kelly and Yorkie have a minor car accident, which scares Yorkie until she realizes she's safe. Nobody's going to get hurt here.
When Kelly takes Yorkie back home with her, Kelly says that her abode "reminds me of where I grew up." Why wouldn't she design a virtual place that looks like home? Yorkie picks up a photograph of a smiling young woman under a banner that says "Happy birthday Alison," and asks Kelly, "Miss your mom?" Late in the episode, Kelly reveals that Alison was her daughter, who died at 39, before the advent of San Junipero. In the show's final moments, Kelly's headstone shows her name — and those of her husband Richard and daughter Alison.
When a postcoital Kelly asks Yorkie about her relationship with her fiancé, Yorkie explains, "It's complicated." Kelly, in return, explains that she had never "acted on" her attraction to women because she was in love with her husband, who "chose not to stick around." Both of their backstories will show those statements are not as simple as they initially appear. The two of them just quietly gaze at each other as the clock turns to midnight, and the screen goes black until once again it's "One week later."
The town's dark, anything-goes club, where denizens with rougher tastes wind up, is called the Quagmire — the word for a murky, difficult to get out of situation. Is the Quagmire the "Black Mirror" version of hell? (There is somebody with horns there, after all.) Purgatory? Just a cautionary warning of what happens when you linger in heaven — or listen to "Walk Like An Egyptian"— too long?
At the Quagmire, Wes offers the episode's first concrete reveal, telling Yorkie to look for Kelly in "a different time." The screen card then reads "One week later" in an early computer-era font and Tucker's has been transformed into a 1980 "Funkytown" dance club. Kelly next skips to 1996, complete with a mid-1990s "One week later" font, where the movie poster is now "Scream."
Another jump, complete with a post-Y2K "One week later" font, and it's 2002, where "The Bourne Identity" is playing. San Junipero really loves its blockbusters about people who aren't what they seem, huh? And when she finds Kelly in 2002, Yorkie exasperatedly asks her, "How the hell is this your era?"
The second half of "San Junipero" pays off all the clues, as the "Black Mirror" time present day Kelly and Yorkie play out their love story. And in the end, as "Heaven Is a Place On Earth" reprises, Yorkie is now shown in the driver's seat as Belinda Carlisle sings she's "not afraid anymore," taking off in her own red car with her loving wife Kelly beside her. In the episode's final shot, Yorkie and Kelly, dancing in eternal bliss at Tucker's in their reality, are also shown to be a small capsule being put into storage in a futuristic facility. The name of the company? TCKR. Well played, "Black Mirror." Well played.


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| Natural Plastic Round Flo Rite Faucet
|70mm Screw Cap Natural Plastic Round Screw Cap
Opening: 70mm Screw Cap
Our 70mm screw cap has a 3/4" center reducer that can be taken out. Once the center reducer is removed, you are able to use a 3/4" Florite faucet (sold separately).


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“Aunt Sammy” was a radio character created by the U.S. Department of Agriculture’s Bureau of Human Nutrition and Home Economics in 1926 to educate homemakers. The show was renamed “Homemaker Chat” in 1934 and ran until 1944. Each radio station had its own “Aunt Sammy,” with all of them reading from the same script.
“Aunt Sammy” was originally described as Uncle Sam‘s sister, although later newspaper articles called her Uncle Sam’s wife. “Aunt Samantha” has been a name for Uncle Sam’s wife since at least 1913.
Google News Archive
18 September 1926, Youngstown (OH) Vindicator, pg. 2, col. 8:
WASHINGTON—Tune in Oct. 4 on the station that registers best and meet Aunt Sammy. Uncle Sam’s bureau of home economics is going to have aunty tell through 30 stations all about the artistic points of housekeeping.
19 September 1926, New York (NY) Times, “RadioFarm School to Open October 4,” pg. X18:
‘Aunty Sammy,” Uncle Sam’s sister, will be heard from thirty stations starting Oct. 4. She will tell about the fine points in housekeeping from stations including: KFOA, KHQ, KPO, WDAF, WGBS, WOC, WOS, WAMD, WRC, WHO, KOIL, KWCR and KMA.
3 October 1926, New York (NY) Times, pg. XX17:
Aunt Sammy, a New
Radio Character, Will
Begin Series on the
BEGINNING tomorrow, Aunt Sammy, supposed to be Uncle Sam’s sister. the first of several new headliners of the United States Agricultural Department, will go on the air from about thirty stations. This will mark a decided step forward in utilizing daylight hours for broadcasting, inasmuch as these features are especially calculated to interest the women of the country.
Aunt Sammy will not confine herself to the subject of cooking, but will include sewing, housecleaning, color scheme for the living room and becoming lines and colors for the stout and thin.
Google News Archive
23 September 1926, Sarasota (FL) Herald, ‘To Broadcast FarmNews in Every State,” pg. 3, col. 2:
The program to be broadcast by WDBO will consist of talks by"Aunty Sammy,” a new radio friend and neighbor, the announcement states, who will be heard from 30 stations. “Uncle Sam’s sister,” as the speaker is called, is the official radio representative of the Bureau of Home Economics of the department. She has a sense of humor, is the friendly sort, and knows all the new wrinkles and fine points in housekeeping, and will tell about them in a style all her own, it was stated.
OCLC WorldCat record
Aunt Sammy’s Radio Recipes. (Broadcast from Oct. 1926 to June 1927.).
Author: United States. Bureau of Home Economics.
Publisher: pp. 86. [Washington,] 1927.
Edition/Format: Book : Government publication : English
27 August 1928, St. Albans (VT) Daily Messenger, pg. 2, col. 3:
Washington, (AP)—“Aunt Sammy,” one of 90 women who give advice on housekeeping and home-making for Uncle Sam’s department of agriculture—is going on the air to Hawaii. She will broadcast daily housewives’ chats to the Hawaiian Islanders.
OCLC WorldCat record
Aunt Sammy’s radio recipes revised
Author: Ruth Van Deman; Fanny Walker Yeatman; United States. Bureau of Human Nutrition and Home Economics.
Publisher: Washington, U.S. Govt. print. off., 1931.
6 April 1975, Mobile (AL) Press Register, “Cooking Is Fun!” by Tommye Miller, pg. 9E, col. 1:
Aunt Sammy’s Radio Recipes, originally written by Ruth Van Deman and Fanny Walker Yeatman, will reappear on April 14, edited and with a long, nostalgic introduction by Martin Greif.
Who was Aunt Sammy, really? This Jazz Age Julia Child was the inspired creation ofthe U.S. Department of Agriculture and its Bureau of Home Economics. She was born in 1926, in the infancy of radio, and until 1944 she continued to advise the housewife good-humoredly on how to feed the family, how to fix a leaky faucet, how to raise both vegetables and babies.
Aunt Sammy was not just one person—as many as 150 women—reading identical scripts as they stood before microphones in radio stations across the country—were Aunt Sammies. Universe Books, which is publishing the new Aunt Sammy Cookbook, is looking for those original Aunt Sammies—anyone who may know of the present whereabouts of any of them is asked to get in touch with the publishers, 381 Park Avenue South, New York City, 10116.
Emporia (KS) Gazette
Aunt Sammy’s radio recipes
Wednesday, May 30, 2007
Aunt Sammy’s Radio Recipes was a 15-minute radio show broadcast five days a week and devoted to up-to-date information for the nation’s homemakers. As you may recall, at this time radio stations had a crew of actors to read texts live on the air, rather than receiving a nationwide broadcast from a single source. So Aunt Sammy in Atlanta would not sound anything like Aunt Sammy in Minneapolis!
According to Ronald Kline (“Consumers in the Country: Technological and Social Change in Rural America”) Aunt Sammy was a character created by the USDA Bureau of Home Economics and the Radio Service to be the “wife” of Uncle Sam. By 1932 the radio show was on 194 stations, but Aunt Sammy faded out during the Great Depression. After 1934 the radio show was renamed “Homemaker Chat” and ran until 1946.
Arcane Radio Trivia
Tuesday, June 12, 2007
Aunt Sammy’s Radio Recipes
Aunt Sammy herself was a character created by the U. S. Department of Agriculture Bureau of Home Economics and the Radio Service to be the ‘wife’ of Uncle Sam. Many women across the country ‘played’ Aunt Sammy at local radio stations when the show aired. The first Aunt Sammy came to life with the first NBC radio broadcast of “Housekeeper’s Chat” on October 4, 1926.
Other Expressions • Origin of "Uncle Sam"/"Brother Jonathan" • (0) Comments • Tuesday, September 27, 2011 • Permalink

domain: library


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How's your art journaling going?
I'm as immersed as ever in my personal art journal (and in my other journals, too). I'm also busy working on all kinds of other projects that seem to be spilling out from my art journal practice, including ATCs (Artist Trading Cards), and several mixed media pieces. I have to say, my wonderful weekly arting group has been great inspiration and motivation—and I don't think I'll be stopping any time soon. Want to see what I'm working on?
I finished this piece:
It is made of layers and layers of collage pieces that took a while to come together, let me tell you, but finally it did! Here's a close-up:
And then I'm still working on two other projects. One is an assemblage grouping that I should complete very soon. Here it is in progress:
And as for the other project, I've just begun is a rather ambitious fiber arts piece—it is sized at almost 24" square—so it will probably take me all winter to finish. It doesn't look like much now:
But here's a close-up of just a beginning of the embroidery. By the time it's done, I'm envisioning thread everywhere!
Good thing, early dark evenings are coming soon. Extra time to snuggle up at home in the evenings and create, create...
I hope that's where you'll be too!
Meanwhile, What's New Here at Hello Heart Journal
I've added two pieces to the website.
One post can be found in the Notes from the Inner Ground collection, called What happens if you art journal? We cover the under belly of the creative process in this post, and I was really glad to be able to share a few recently created ATCs, too.
I've also added a HUGE tutorial on image transfers to the Tutorial Library!
This project is a result of a bit of long-term curiosity about different methods for making image transfers. Image transfers are such great, transparent elements to use in mixed media. So I did a good deal of research and experimentation until I became quite familiar each of them.
So why keep it to myself? You can find information about transfer processes all over the internet, but I realized it could be super useful to people to 1) Get step by step instructions in one place for seven of the most common different methods, and to2) Get some clarification about what method to use for what kind of image—especially when doing transfers in your art journal.
So here it is! Tutorial: Seven Image Transfer Methods for Toner, Magazine and Inkjet Images. If you're interested in learning how to make image transfers with different methods, you now have one place to go for help. Enjoy!
A little behind the scenes talk
This was my largest tutorial project yet, and I have to say after doing it that I have so much more respect for art journal bloggers who put out tutorials all the time, like Julie Fei-Fan Balzer of Balzer Designs and Jenniebellie of Jenniebellie studios (two of my favorite online art journalers.) Wow—it literally took me months to put this image transfer tutorial together, and they seem to create both video and blog tutorials every week!
For me,the step-out photos was definitely the most challenging aspect of the project—and they took the most time—taking the right photos, editing them and then uploading them. But...now that this massive tutorial is completed and uploaded, I'm very glad I could share what I know with you! I'll definitely be adding more tutorials to Hello Heart Journal in the months to come—maybe not seven techniques in one, but yes, I'll be adding more tutorials.
Speaking of the future
I have lots of plans. My current personal journal is nearing completion and I'm working faster just so I can finish it and move on to the next one! I now know the exact "specifications" I want for this kind of journal—covers, binding, size, paper content, what multiple uses I have for said paper—so of course I will need my own custom book . I'll be making this journal soon and I will definitely share both how I make use this kind of journal .
That's just the beginning of projects to make and share. And not only that, but I think I'm about to take some seriously exciting new steps in my arting life/journey—which I can 't share just yet, but soon...but I will!
Given all that I'm up to, a quick word about this newsletter if I may...
I started out not knowing how often I'd be creating Latest@Hello Heart Journal, but I think I've found a really good creative (and balanced) rhythm: I make things all month (website posts, art journal pages, mixed media pieces) and I'm sharing as I go on Instagram and Pinterest. So it feels right that I write the newsletter just once a month to update you on all that's going on. It feels right in my life and I hope if you're subscribed that this email schedule serves you as well. There's no need to clutter up your inbox with more news then you need.
If you're aren't subscribed yet and your reading this on my website, please subscribe by clicking on the subscribe button in the sidebar (or at the bottom) of this page. You too can get updates delivered directly to you email inbox!
And finally, if you ever have any questions or feedback you'd care to share...
Please, always feel free to email me here or send comments on your social media of choice, Instagram or Pinterest:
I'll be sure to get back to you.
So that's it, folks! I feel like I'm in a "create my HeArt out" phase right now and I do hope what I share will inspire you to create your HeArt out, too!
Have a great month!

domain: artistic


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Lewisville Independent School District
Construction updates at new elementary school.
Construction continues at new elementary school.
Construction begins at future campus.
There are no upcoming events to display.
Current LISD families are asked to submit an interest form in Skyward Family Access accounts for a potential 2021-22 virtual learning program.
LISD seeks parent input for campus profiles.
Honor recognizes district’s commitment to digital citizenship.


Find a Professional in Florence, Massachusetts
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COMMONLY ASKED QUESTIONS ABOUT CENTRAL AIR CONDITIONING REPAIRS & MAINTENANCE
What is the typical price for air conditioning repairs?
Normally air conditioning repairs cost between $100 - $650, depending on how complex it may be to fix. Replacement parts can affect this price too, and if a part can't be replaced, it'll cost more to replace the unit. There are a few important factors that are accounted for in the price, including the unit's size, which components are impacted, and the extent of labor needed. Central air conditioning is a highly effective and convenient modern unit with midrange costs when compared to other choices. It's essential to think about the cost of the parts themselves in addition to labor and invest in services delivered by a skilled and equipped technician.
How do you define the extent of air conditioning repairs?
HVAC professionals take a full-scope approach to air conditioning repairs so that all its components and systems will keep functioning correctly. Preventative maintenance is meant to extend the lifespan of the unit and get it to operate as effectively as possible. During a yearly maintenance check, these parts are assessed to figure out if repairs are needed:
- Condenser fan motor and drainage
- Blower motor and ductwork
- Fins and condenser coils
- Evaporator and condenser controls
- Refrigerant level (check for leaks)
- Disconnects and access panels
- Electric connections
What are the measures you need to take for maintaining a central air conditioner system?
Maintaining a central air conditioning system can include cleaning dirt off the coils, checking that the condensate drain line is clear, and replacing air filters. Like any major home appliance, preventative maintenance will allow your system to run as optimally as possible. Its increased lifespan will cool down your home even when the weather is at its hottest outside. Simply ensuring that nothing is cutting off the fan, drains, and other critical components will allow sufficient airflow and cooling. While this sort of regular cleaning is simple to do yourself, you need to hire a professional HVAC specialist once a year to do a complete inspection.
How do you know when air conditioning repairs are needed?
There are some signs that can signal if your AC has been running past its limits. Having an idea of what to look for can help maintain your system and keep it functioning to the best of its ability. An HVAC specialist can offer the right upkeep, preventing worse issues and a costly replacement. These are some of the problems you might see when your air conditioning unit requires repairs:
- Blows warm air
- Thermostat not working
- Inefficient airflow
- Loud noise
- Strange odors
- Excess humidity
- More frequent problems
- Freon or water leaks
- Rise or high electric bills
- AC lifespan is over
Tuneups need to be made as needed, but maintenance checks are only required a couple of times a year. If you observe any of these problems, you can hire an HVAC contractor to check out your unit and offer the necessary maintenance services.
Find an Experienced Contractor for Central Air Conditioning Maintenance in Florence, Massachusetts
Make your home more pleasant by staying up-to-date on maintenance for your central air conditioning system. Ensuring that your AC is operating to the best of its ability is simple with a yearly inspection, which will pick up on any issues and the repairs required to fix them. Hiring a technician to handle maintenance services will prevent issues from getting worse and help you avoid expenses related to replacement parts, labor, or installing a whole new unit. A trained HVAC contractor will know what to look for and how to take care of central air conditioning repairs through their experience working in the field.
Thumbtack is a user-friendly home management platform that's more convenient for homeowners to search for professionals to take care of upkeep. If you require air conditioning maintenance, just download the app and search for a technician in Florence, Massachusetts. Take a look at numerous profiles for HVAC professionals and companies, highlighting their greatest advantages and services so you can make an informed decision. Our app simplifies the decision-making process so a skilled air conditioning contractor can begin repairs as soon as possible. You can narrow down your options, communicate directly, and ask for an estimate or consultation all in one place!
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You may have read about the many potential health benefits of CBD, but you may not know how effective CBD is against the flu. While it shouldn’t take the place of appropriate medical care, CBD can be an effective aid in managing the flu and flu-like symptoms. For those suffering through a bout of the worst of all season, flu season, it can help them get some relief and feel better faster.
CBD For Wellness
CBD is short for cannabidiol, one of just over a hundred active compound called cannabinoids found in industrial hemp. When used, it acts on your body’s endocannabinoid system, where it can create certain effects in the body. Some of these effects are precisely what make CBD great against the flu.
Go Away Flu, Nobody Likes You
The flu isn’t a single virus; rather, it’s a range of viruses that share certain characteristics. This variety of viruses is why, even with a flu vaccine, many people still get the flu. The vaccine is actually based on predictions made by virologists about which strains will be prevalent in any given year. If you are exposed to another strain, the vaccine has reduced effectiveness or may not work at all.
As a virus, these illnesses can’t be cured by antibiotics or antibacterial remedies once you’re exposed. All you can do is manage the symptoms and allow it to run its course. Even medication assigned by your doctor will not cure your flu, but it is meant to make you feel better. CBD may also help with these same flu symptoms, making it a smart choice to use CBD against the flu if you want to be back on your feet quicker.
What CBD Won’t Do
CBD is not a medicine, so it won’t help you diagnose, cure, treat, or specifically prevent the flu. Using CBD does not take the place of competent medical care, though you may decide for yourself if you want to use it in addition to any treatment. Many people choose to use CBD against the flu symptoms that cause them the most suffering while they’re infected.
How CBD Can Help
Very little peer-reviewed studies are available about the benefits of CBD. Due to its decades of treatment as a controlled substance along with its psychoactive cousin, marijuana, evidence has been limited to smaller research programs, anecdotal experiences, and, more recently, preliminary results from better-funded studies since legalization. So far, this evidence has pointed to the effectiveness of CBD against flu symptoms.
- Achiness – The achiness that often is associated with the flu is primarily due to the inflammation it causes in your body as your immune system works to eradicate the virus. Some research indicates that cannabis has anti-inflammatory effects that help minimize this inflammation for less pain and discomfort.
- Headaches – Another painful part of having the flu are the splitting headaches it can bring. These often occur for a variety of reasons. Inflamed sinuses can lead to powerful front-of-the-head pain that makes it hard to focus. The stress involved in illness and missed work can lead to stress headaches that settle behind the eyes and in the base of your skull. CBD is suspected of having an analgesic effect in addition to its anti-inflammatory properties to help combat most headaches, while it’s calming influence leads to better stress management.
- The Blahs – One of the hardest flu symptoms to quantify is the way a serious illness makes you feel mentally and emotionally. Using CBD against the flu “blahs” is an easy way to support a positive and healthy outlook while you recover. Users report that CBD gives them a sense of calm and well-being, and while positive thoughts may not cure the flu, studies show positivity leads to better healing outcomes.
- Nausea – It’s not uncommon to experience an upset stomach during a bout of the flu. You don’t want to eat, and the thought of food may make you sick, but your body needs fuel to fight off the viral invader. Fighting nausea with CBD has long been a tactic espoused by some CBD users, particularly those fighting nausea associated with chemotherapy.
- Lack Of Sleep – Between the pain and the sniffling, it can be hard to get a good night’s rest when you’re fighting the flu. Using CBD against the flu can be a great way to promote better sleep. The mental calm that CBD can help you find makes it easier to relax. A good night’s sleep is important anytime, but when you’re ill, it’s especially needed.
Better Health And Wellness Year Round
The best way to fight the flu is to prevent it. This includes taking extra sanitation and hygiene precautions during flu season, like washing your hands and using hand sanitizer more often or cleaning areas of your home or office where common use could spread germs. It can also include using your CBD products. Many users feel that a regular CBD regimen helps strengthen their immune system, giving their body the help it needs to better fight off illnesses when exposure occurs. That means you can use CBD against the flu before you have it.
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This 23 March 2019 video says about itself:
Tracking Giant Galapagos Tortoises | BBC Earth
From the Ecological Society of America:
Giant tortoises migrate unpredictably in the face of climate change
Unlike many migratory species, Galapagos giant tortoises do not use current environmental conditions to time their seasonal migration
April 18, 2019
Summary: Researchers use GPS to track the timing and patterns of giant tortoise migration over multiple years. The tortoises often take the same migration routes over many years in order to find optimal food quality and temperatures. The timing of this migration is essential for keeping their energy levels high, and climate change could disrupt a tortoise’s ability to migrate at the right time.
Galapagos giant tortoises, sometimes called Gardeners of the Galapagos, are creatures of habit. In the cool dry season, the highlands of the volcano slopes are engulfed in cloud which allows the vegetation to grow despite the lack of rain. On the lower slopes, however, there is no thick fog layer, and vegetation is not available year round. Adult tortoises thus spend the dry season in the higher regions, and trek back to the lower, relatively warmer zones where there is abundant, nutritious vegetation when the rainy season begins.
The tortoises often take the same migration routes over many years in order to find optimal food quality and temperatures. The timing of this migration is essential for keeping their energy levels high, and climate change could disrupt a tortoise’s ability to migrate at the right time.
In the Ecological Society of America’s journal Ecology, researchers use GPS to track the timing and patterns of tortoise migration over multiple years.
“We had three main goals in the study,” says Guillaume Bastille-Rousseau, lead author of the paper. “One was determining if tortoises adjust their timing of migration to current environmental conditions. Two, if so, what clues do they use to adjust the timing, and, three, what are the energetic consequences of migration mis-timing for tortoises?”
The researchers expected the migrations to be timed with current food and temperature conditions because many other migratory species operate that way. Bastille-Rousseau says “many animals, such as ungulates, can track current environmental conditions and migrate accordingly — what researchers sometime refer to as surfing the green-wave.”
Contrary to the researchers’ expectations, however, migration is weakly associated with current conditions such as fog, rain, and temperature. For instance, if it is unseasonably arid, it appears the tortoises do not take that variation into account when deciding it is time to migrate. It is unclear at this point whether they are basing their migration decisions on memories of past conditions or if they are simply incorrectly assessing current local conditions.
Bastille-Rousseau says the team is surprised by the mismatch, stating “tortoise timing of migration fluctuated a lot among years, often by over two months. This indicates that migration for tortoises may not just be about foraging opportunities. For example, female tortoises have to make decisions related to nesting, and we still have a lot to learn about migration in giant tortoises.”
Fortunately, this sub-optimal timing may not yet have critical impact on tortoise health. Potentially due to their long lives of up to 100 years and large body size, bad timing of migration has smaller consequences for giant tortoises compared to small, short lived animals. Giant tortoises can go up to a year without eating and survive, while other migrating species must eat more regularly to sustain their energy levels.
Giant tortoises are important ecosystem engineers in the Galapagos, responsible for long-distance seed dispersal, and their migration is key for many tree and plant species’ survival. How the tortoises’ variation in migration timing will affect the rest of the ecosystem is still unclear. Because tortoises do not seem to be tracking annual variation in environmental conditions, it is quite possible that the mistiming of migration will keep increasing in the future.
“One concern is that at some point in the future,” Bastille-Rousseau adds, “migration may not be an optimal strategy for tortoises. There may be a reduction in the number of individuals doing these long-distance movements. This would likely have cascading consequences for the whole ecosystem.”
THE CLIMATE KIDS ARE ALL RIGHT The last five years were the five hottest on record. The amount of carbon dioxide in the atmosphere has soared past 410 parts per million. As many as 150 species die off each day. As the call for action grows louder, the youth climate movement ― which scientists say has moved the needle on action to address the climate emergency ― is taking center stage. [HuffPost]
HAWAII BEACHES MAY SOON BE UNDERWATER Hawaii’s iconic Waikiki Beach could soon be underwater as rising sea levels caused by climate change overtake its white sand beaches and bustling city streets. State lawmakers are trying to pass legislation that would spend millions for a coastline protection program. [AP]
A new Stanford University study shows global warming has increased economic inequality since the 1960s. Temperature changes caused by growing concentrations of greenhouse gases in Earth’s atmosphere have enriched cool countries like Norway and Sweden, while dragging down economic growth in warm countries such as India and Nigeria: here.
Chinese Satellite Takes An Astounding Pic of Earth And Far Side Of The Moon Together https://www.knowledgeinflux.info/2019/06/chinese-satellite-takes-astounding-pic.html
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Harvey Norman Shuts Norman Ross NZ
A closing down sale was advertised at the storefront of its Norman Ross Palmerston North store in New Zealand, as reported by Fairfax media.
However, a company spokesperson denied the store was closing: it “is being rebranded as a Harvey Norman store” and the company is phasing out the Norman Ross brand and its three stores.
“The Harvey Norman brand is our primary brand and we are looking at strengthening this by rebranding the Norman Ross stores to Harvey Norman stores,” the spokesperson said.
Harvey Norman operates Norman Ross stores also in Auckland and Christchurch, and these too are being shut and rebranded as their Aussie parent Harvey Norman, CN can confirm.
An employee at the Auckland store told CN: “there was no more growth in the Norman Ross” stores and the company wanted to progress as Harvey Norman.
Harvey Norman said New Zealand sales fell 1.3% in Q1 2013 July- September.
The Norman Ross store at Palmerston North will close on February 28 as will Christchurch.
|All staff are to be retained and deployed into the rebranded Harvey Norman store.
The first Norman Ross store opened in Wellington in December 2007. The retailer is due to release its earnings figures soon.
Harvey Norman Shares fell -0.42% to $2.36 on the ASX today.


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AsianScientist (Oct. 12, 2020) – With the recent Nobel Prize in Chemistry recognizing the achievements of CRISPR pioneers Emmanuelle Charpentier and Jennifer Doudna, all eyes are now on the gene editing technology. Since the fateful 2012 paper detailing its potential to rewrite the code of life, CRISPR has already ushered in a new age of biotechnology and surely, there’ll be more innovations to come.
From new variants of Cas9—otherwise known as the molecular scissors of the CRISPR-Cas9 duo—to kill switches aptly called anti-CRISPR proteins, find out about what’s next for CRISPR in the infographic below.
This infographic was first published in the July 2020 print version of Asian Scientist Magazine.
Click here to subscribe to Asian Scientist Magazine in print.
Copyright: Asian Scientist Magazine.
Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff.


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Petzl Big Wall & Protection Gemini Prusik Minding Pulley P66A.
The Gemini Double Pulley by Petzl. The GEMINI double pulley is equipped with an auxiliary attachment point for use in Technical hauling systems. Features of the Petzl Gemini Double Pulley Special side plates designed for use with a Prusik friction hitch in progress capture systems Parallel mounted sheaves and auxiliary attachment point for creating different types of hauling systems Sheave mounted on sealed ball bearings for excellent efficiency Compact and lightweight
Description of Petzl Gemini Double Prusik PulleyThe Gemini double pulley is equipped with an auxiliary attachment point for use in technical hauling systems.FeaturesSpecial side plates designed for use with a Prusik friction hitch in lightweight progress capture systemsParallel mounted sheaves and auxiliary attachment point for creating different types of hauling systems, even the most complexSheave mounted on sealed ball bearings for excellent efficiencyLightweight aluminum side plates and sheavesSheave diameter 25 mmRope diameter 7-11 mmEfficiency 91 Weight 135 g3-year guarantee.Materials aluminum side plates, aluminum sheave mounted on sealed ball-bearingsWorking load 6 kN 1.5 kN on one rope endBreaking strength 23 kN
- US Outdoor Store
Petzl's Gemini Double Prusik Pulley lets you set up a variety of hauling systems with either one or two ropes. It features sheaves mounted over sealed ball bearings for smooth efficiency, and the unique side plates work with the auxiliary attachment to accommodate complex capturing systems or simple Prusik hitches for lighter hauls. Despite its double dimensions, the Gemini remains small and light enough for any big wall, alpine, or mountaineering endeavor.


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Miyako Messe & Kyoto Museum of Traditional Crafts - Fureaikan みやこめっせ
The Miyako Messe has three spacious exhibition halls and a special exhibition hall.
Many of the exhibitions and trade fairs are put on by traditional Kyoto industries such as kimono and other Kyoto-based arts and crafts manufacturers. More contemporary Kyoto industries are also prominent.
The Miyako Messe also has a restaurant/cafe on the first floor.
Kyoto Museum of Traditional Crafts - Fureaikan
The Kyoto Museum of Traditional Crafts - Fureaikan (京都伝統産業ふれあい館) in the basement of the Miyako Messe is a superb display of literary hundreds of Japanese crafts. Free to enter, the museum's exhibits are explained in both Japanese and English.
On display are examples of bamboo crafts, stone lanterns, landscape gardening, stone work, roof tiles, braid tassels, weaving, embroidery, kimono, tabi socks, wigs (katsura), kanzashi hair decorations, wooden combs (kushi), paper umbrellas, chochin lanterns, kiseru pipes, dolls (ningyo), masks, tatami mats, sudare blinds, lacquerware, karuta (cards), ceramics, fans (both folding fans, sensu and the paddle-shaped uchiwa), byobu folding screens and traditional Japanese wooden toys such as koma spinning tops.
The list of exhibits continues with mizuhiki, sake, temple and shrine goods such as mikoshi portable shrines, gold leaf, tansu chest of drawers, butsudan Buddhist altars, juzu and nenju rosaries, candles, incense, Japanese swords and suits of armor and musical instruments including flutes.
The Fureaikan is a superb introduction to Japanese arts and crafts and crafts people are on hand giving demonstrations of their skills (except Mondays). The adjacent museum store also has many of these arts and crafts for sale.
Photography is prohibited within the museum.
There are occasional performances by maiko (trainee geisha) on Sundays.
Japan Design Museum
Also in the basement is the Japan Design Museum established by the Japan Designers Association. The museum stages design related events such as a design festival and design shows with participation by the general public. The kid's art show shows the work of children from all over the country.
Access - how to get to the Miyako Messe
9-1 Okazaki Seishoji-cho
Sakyo-ku, Kyoto 606-8343
Tel: 075 762 2630
The nearest stop on the Kyoto subway to Miyako Messe is Higashiyama Station on the Tozai Line.
Kyoto city buses #5 and Raku bus #100 depart from Kyoto Station; from Shijo Kawaramachi Station on the Hankyu Line take buses #5, #32 or #46; Get off the #5 and #100 buses at the Okazaki Koen/Bijutsukan, Heian Jingu-mae stop. The #32 and #46 buses stop at the closer Okazaki Koen/ROHM Theatre, Miyakomesse-mae stop. Buses #201, #202, #203 and #206 stop at the Higashiyama Nijo, Okazaki Koen-guchi stop a little to the west.
Miyako Messe is across the street from the Rohm Theater and close to a number of other attractions including Heian Shrine, The National Museum of Modern Art Kyoto, the Kyoto Municipal Museum of Art, the Kyoto Zoo, Kyoto Prefectural Library, Kumano Jinja, Kyoto Budo Center, Shogoin Temple and Kyoto Handicraft Center.
For a full listing of Kyoto Museums & Art Galleries click here


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After passing the regressive anti-LGBTQ+ “Don’t Say Gay” bill into law in March, the state of Florida is taking a few tips from Texas Republicans by trying to stop transgender youth from accessing gender-affirming healthcare.
On Wednesday, the Florida Department of Health issued non-binding guidance for state agencies via press release urging an end to both social and medical transitioning for trans youth.
“Social gender transition should not be a treatment option for children or adolescents,” the document reads, adding that “puberty blockers” and “hormone therapy” should not be prescribed to those under 18.
The guidance, which was supported by Gov. Ron DeSantis, is a direct response to a March publication from the U.S. Health and Human Services department stating that “early gender affirming care is crucial to overall health and well-being.” Although it does not ban the provision of transition-related medical care as laws in other states do, the press release signals that the state government sides with anti-trans practitioners who refuse to provide care to young people.
“This guidance demonizes life-saving, medically-necessary care, and asserts that the government, not parents, knows best when it comes to health care for our children,” the statewide LGBTQ+ advocacy organization Equality Florida wrote in a statement. “And, once again, DeSantis wants the government to intrude into doctors’ offices to pander to extremists in service to his political ambitions.”
Like many such Republican actions this year, the Florida release makes special exceptions for doctors who perform nonconsensual surgeries on — or prescribe puberty blockers and hormone therapy for — intersex youth. For everyone else, the DeSantis administration claims, the “lack of conclusive evidence” for the health benefits of transitioning demands that such care be effectively outlawed. (Contrary to these assertions, medical consensus indicates trans-affirming care and social transitioning is helpful for both trans youth and adults.)
This new guidance came just ahead of the Florida legislature’s vote on Thursday to strip the Walt Disney Company of its “special district” status for the Disney World resort, after the company belatedly opposed the passage of the “Don’t Say Gay” bill.
DeSantis has publicly accused the company of promoting a “woke” agenda, and far-right pundit Laura Loomer organized a protest outside of the park last week, where conservatives gathered with signs accusing the company of grooming children.
“Once again, the DeSantis Administration seeks to replace science and the safety of young people with political propaganda,” Equality Florida noted. “Governor DeSantis [...] is putting a handful of extremists in charge of every aspect of the lives of Floridians and is making the state less safe for LGBTQ families, especially transgender children.”
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Recycling crucial to support India’s Li-ion EV battery manufacturing
The electric vehicle (EVs) is a rapidly growing segment in India, especially in the two-wheeler category, most of which are powered by lithium-ion batteries. At present, India majorly relies on imports to fulfill its demand for the elements required for manufacturing li-ion cells used in EV batteries due to the lack of raw materials on our shores.
As a result, the rapid growth ofelectric vehicles has created a pressing environmental challenge: what to do with the discarded batteries that represent both a resource and a hazard? In a conversation with TOI Auto, Vikrant Singh, CTO & Co-Founder of Bat X Energies, explains their business model, expertise, importance of environmental sustainability, and their plans for the future.
The company, which was founded only recently in 2020, reclaims and recycles essential Earth metals like Lithium, Cobalt, Nickel, and Manganese from discarded Lithium-ion cells and seamlessly reintegrates them into battery production.
Speaking about the company’s business model and challenges that it faces, Singh said “Our business model centers on producing battery-grade materials through recycling, particularly from sources like spent batteries from EV sector, electronics, telecom sector etc. Our zero waste zero emission proprietary technology facilitates therecycling process of these materials, which are commonly found in household items such as mobile phones and electric vehicles.
These materials, including lithium, cobalt, and nickel, find applications in various industries like pharmaceuticals, ceramics, paints, and electroplating.”
“However, the challenge lies in collecting batteries from diverse locations across India, resulting in high logistical costs and safety risks. To address this, we’ve devised a ‘Hub and Spoke’ strategy in collaboration with OEMs and channel partners.
This strategy streamlines the pickup of end-of-life lithium-ion batteries, enhances coordination, ensures compliance with regulations, and enhances traceability.”
Giving a glimpse of the steps involved in the recycling process, Singh elaborated “Our recycling process comprises both mechanical and chemical stages. The seven-layer mechanical process efficiently separates Black Mass from other materials, yielding high-grade Black Mass with minimal impurities.”
“Simultaneously, secondary materials like plastic, aluminum, steel, and copper are effectively separated for their respective applications. In the chemical (hydrometallurgy) stage, we employ reusable chemicals specifically synthesized for repetitive use. These chemicals extract rare earth metals like lithium, cobalt, nickel, and manganese, which are then reintroduced into the supply chain.” he added.
These materials are then supplied to battery cell manufacturers, closing the loop in thecircular economy for lithium-ion battery manufacturing and electric vehicles. Additionally, the company produces batteries from recycled materials and exports them to brands worldwide.
Singh, speaking on the importance of recyclingli-ion batteries and the threat they represent to the environment added “Few years back, while doing our research we found that li-ion batteries run for 3-7 years in EVs.
There is a huge hazardous waste stream that gets generated. Further, to manufacture lithium ion cells India doesn’t have any of the rare earth materials, therefore we will always be dependent on imports. The limited raw material supply chain made us work on the circular economy phenomenon.”
“E-waste improperly disposed of can severely harm the environment, including soil and water contamination and risks to human health, as lithium-ion batteries are host to toxic elements, including cobalt, nickel, and manganese.
Hence, the need for proper disposal and recycling of these batteries to minimize environmental impact has surged the need for lithium-ion battery recycling in India.”
While currently operating nationwide in India,BatX Energies told us about their bold expansion plans. Recognizing the challenges faced by countries without natural resources for critical raw materials in the electric mobility sector, they aim to enter markets such as South Africa, the USA, and Europe in the near future.
“We plan to bring advanced R&D for producing battery-grade materials, scaling up their capacity, and setting up micro facilities (spokes) across the country and aim to source and process locally. Through this it will also bring about an increase in job opportunities and a skilled workforce in the electronic waste management sector.” Singh noted.

domain: chemistry


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Foods To Spice Up Your Sex Life — Candice Kumai’s Recipes (Access Hollywood Live)
First Published: August 13, 2012 11:56 AM EDT Credit:
LOS ANGELES, Calif. -- It’s been said the way to a man’s heart is through his stomach. So, does this recipe for love work for women as well?
Candice Kumai, a contributor to Men’s Health magazine’s: “Cook For More Sex,” says women do get turned on when their guy cooks for them.
Candice dropped by Access Hollywood Live and shared the recipe for libido enhancing meals.
SPICY PEANUT NOODLES WITH CHICKEN:
1/2 pound whole wheat spaghetti
1.5 teaspoon sea salt
1 tablespoon dark sesame oil
2 skinless, boneless chicken breast halves
3 garlic cloves, minced
1 serrano chile, minced
1/4 cup creamy all-natural peanut butter
3 tablespoons honey
3 tablespoons reduced-sodium soy sauce
3/4 teaspoon red pepper flakes
1 cup sliced shiitake mushroom caps
1 red bell pepper, thinly sliced
1 cup fresh arugula
2 scallions, thinly sliced
Bring pot of water to boil and cook pasta until al dente, 8 to 10 minutes. Reserve ¼ cup of the pasta water. Rinse cooked and drained pasta under cold running water for a minute or two to chill noodles.
Heat the oil in a large skillet over medium heat. Add the chicken and cook, stirring often, until golden-brown on all sides and cooked through, about 8 minutes. Set chicken aside.
Add the serrano chile and garlic to the pan and cook until fragrant, stirring often, about 1 minute. Stir in the peanut butter, honey, soy sauce, pepper flakes, and reserved cooking water and cook until it becomes creamy, about 2 minutes.
Add the mushrooms and peppers. Cook, stirring often, until the vegetables are tender, 2 to 3 minutes.
Stir in the cooked chicken and the drained noodles, toss in the arugula greens and serve sprinkled with the scallions.
SEXY FISH TACOS:
For the fish:
1/2 cup fresh lime juice
3 tablespoons plus 2 teaspoons extra-virgin olive oil
2 tablespoons chopped fresh cilantro
1/2 teaspoon ground cumin
1/2 teaspoon cayenne pepper
1/4 teaspoon sea salt
1.5 pounds mahi-mahi fillets
TEQUILA LIME SAUCE:
1/2 cup nonfat plain Greek yogurt
2 tablespoons tequila
1 teaspoon grated lime zest
1 tablespoon fresh lime juice
1 teaspoon chopped cilantro
FOR THE TACOS:
2 teaspoons canola oil
12 6-inch corn tortillas
2 limes cut in wedges
Marinate the fish: Whisk the lime juice, olive oil, cilantro, cumin, cayenne and salt together in bowl. Add the fish fillets and turn to coat. Cover the bowl with plastic wrap and refrigerate for at least hour or up to 3 hours.
For the sauce, whisk the yogurt, tequila, lime zest and juice, and cilantro together in a small bowl. Cover with plastic wrap and refrigerate until serving.
Heat a charcoal or gas grill to high heat or heat a ridged cast iron grill pan to high heat. Use paper towels and tongs to grease the grill’s grates with remaining canola oil. Remove fish from marinade and grill without turning until its firm and opaque (about 4 to 5 mins). Transfer fish to plate and break it up into bite-sized pieces. Stack the tortillas and wrap them in damp paper towels. Place them on a plate and heat up in microwave for 10-second increments (about 30 seconds).
To serve, divide fish among tortillas. Top with some cabbage slaw and radish slaw and serve with tequila sauce and a fresh lime wedge.
Copyright 2013 by NBC Universal, Inc. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Fluffy white cupcakes are made perfect with a cake mix and a lot of add ins to make them special. They are the perfect texture, flavor and will quickly become your favorites as well!
These cupcakes start with a box mix, but with a lot of twists turn into something magical. I dare say they are the best white cupcakes out there and that’s really saying something coming from me!
They are soft and spongy and oh so tasty. You will have to make a batch to see for yourself!
You know I am usually a big fan of homemade cakes. I have a ton of great cake recipes here on the blog.
Honestly most of them are almost as easy to make as a mix, they just have a few more ingredients to measure.
That doesn’t mean that I don’t understand the allure of a mix. They instill a sense of confidence and give you something to build from.
In fact the chocolate cherry fudge bundt cake that my family absolutely loves starts with a mix (and a can of cherry pie filling!) Sometimes easy recipes like that are exactly what you need.
So lately I’ve been on the hunt for the perfect ways to doctor up cake mixes for cupcakes. I’ve been having the best time decorating them and want to make fun cupcakes every weekend!
There are so many suggestions for hacks out there. So I had been trying a few to find my favorite.
Truthfully, both tasted delicious, but nobody is hunting for a recipe that makes sinking center cupcakes! I love cakes with plenty of sour cream or yogurt mixed in and it turns out you need to add more flour and sugar to get the texture I was after.
This recipe is very similar to the semi-homemade chocolate cupcakes in that there are so many mix ins you end up with half again as many cupcakes. That’s right, 36 cupcakes instead of 24!
Luckily extra cupcakes are not a problem in my neck of the woods. In fact, I purchased some bakery style plastic cupcake holders which make them easy to give away and transport.
I’ve also frozen them fully decorated in the containers and they have defrosted beautifully! I just pulled them out a week or two later and let them sit on the counter for an hour or so to defrost. Everyone was amazed how good they still were.
I’ve piped the perfect summer buttercream on them and Italian meringue buttercream and both were amazing. I tell you the texture of these cupcakes is perfect and any frosting is just the literal icing on the cake!
What makes these cupcakes perfect?
So many things!
The texture is so soft and spongy. It is the perfect mix and they are so light and yummy.
They stay so bright and white. So the tops that are showing under the frosting are pearly.
They taste like wedding cake. Top them with delicious buttercream and it will transport your tastebuds to a reception hall.
In fact I’ve made these for a wedding. I’ve made them for birthdays, bbqs and parties too.
If you like filled cakes, they are perfect for that too. Put a little lemon curd or raspberry filling in the center and your mind will be blown.
- 1 white cake mix
- 1 cup flour
- 1 cup sugar
- 1/2 teaspoon salt
- 1/4 teaspoon baking powder
- 1 1/3 cups water
- 2 Tablespoons vegetable oil
- 1 teaspoon vanilla extract
- 1 teaspoon additional extract (lemon, almond, creme boquet, additional vanilla)
- 1 cup sour cream
- 1/2 cup egg whites (from about 4 large eggs)
- Preheat oven to 325°F and place cupcake liners in 36 cupcake wells.
- In a large mixing bowl, whisk together cake mix, sugar, flour, salt and baking powder until well mixed and lump free.
- Add in wet ingredients and beat on low until the ingredients combine. Then beat on medium for two minutes.
- Scoop into lined cupcake tins (a large cookie scoop or ice cream scoop works perfect for this!)
- Bake for 18-22 minutes or until the tops spring back when lightly touched with a finger. (They shouldn't take on much color.)
- Cool in tins for about 5 minutes then remove to a wire rack to cool completely.
As an Amazon Associate and member of other affiliate programs, I earn from qualifying purchases. Please view my disclosure page for more information.
Amount Per Serving: Calories: 102Total Fat: 2gSaturated Fat: 1gTrans Fat: 0gUnsaturated Fat: 1gCholesterol: 4mgSodium: 48mgCarbohydrates: 10gFiber: 0gSugar: 7gProtein: 1g
All nutritional information is estimated and will depend on the exact ingredients you use.

domain: hobby