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FRIDAY, Jan. 3, 2020 (HealthDay News) — Proton chemoradiotherapy is associated with a significantly lower risk for 90-day adverse events and a decrease in performance status during treatment compared with photon therapy, according to a study published online Dec. 26 in JAMA Oncology.
Brian C. Baumann, M.D., from the University of Pennsylvania in Philadelphia, and colleagues conducted a retrospective, nonrandomized comparative effectiveness study involving 1,483 adults with nonmetastatic, locally advanced cancer treated with concurrent chemoradiotherapy. Overall, 391 received proton therapy and 1,092 received photon therapy.
Patients receiving proton therapy were significantly older (median, 66 versus 61 years) and had less favorable Charlson-Deyo comorbidity scores (median, 3.0 versus 2.0). The cohorts had similar baseline grade ≥2 toxicity and Eastern Cooperative Oncology Group performance status. The researchers found that proton chemoradiotherapy was associated with a significantly lower relative risk for 90-day adverse events of at least grade 3, 90-day adverse events of at least grade 2, and a decline in performance status during treatment (relative risks, 0.31, 0.78, and 0.51, respectively) in propensity score-weighted analysis. No difference was seen in disease-free or overall survival.
“Reduced adverse events associated with proton therapy could offer an opportunity to intensify chemoradiotherapy treatments and/or broaden inclusion criteria on clinical trials to include older, sicker patients, which may improve oncologic outcomes,” the authors write.
Two authors disclosed financial ties to the pharmaceutical and medical device industries.
Copyright © 2020 HealthDay. All rights reserved.


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The Courtesan Handayu of the Nakaomiya House of Pleasure - Attractive image of the courtesan Handayu of the Nakaomiya House strolling through the street, looking down with a pensive expression. Her hands are tucked inside her red under robe, held up to her face beneath the cloth. A large paper lantern rests at her feet, and in the room at right, an elegant bonsai tree and plants are arranged in a ceramic planter decorated with a red sun above splashing waves. The title cartouche takes the form of a folded love letter at upper left, which is also the title of the series. A lovely design, rarely seen in reprint.
Artist - Buncho (active 1765 - 1792)
Image Size - 12 1/4" x 5 3/4"
Condition - This print with excellent color and detail as shown. Please see photos for details. Nice overall.

domain: artistic


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domain: medical


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In response to our Hurricane Harvey Psychological Trauma Support Project, CNN Impact Your World featured RMF as a list of active non profits working in Houston.
Real Medicine Foundation is collaborating with Dr. Kevin Becker and his team at Organizational Resilience International, who we worked with during our Hurricane Katrina relief efforts in 2005.
RMF believes that disaster survivors are most drawn to, and best served, by the natural supports in their community. Thus, we will also partner with local community members and relevant local institutions. By enlisting community members themselves to work alongside us in the recovery process, we thereby further their empowerment and recovery.

domain: geography


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From the “joyous coming of age drama” of Blinded By The Light to Pedro Almodóvar’s latest, find out what’s coming to Picturehouses across the country this week in our round-up!
Blinded By The Light
From director Gurinder Chadha (Bend It Like Beckham) and based on British journalist Sarfraz Manzoor’s celebrated rite of passage memoir Greetings from Bury Park, Blinded By The Light chronicles his experiences as a British Muslim boy growing up in 1980s Luton and the impact Bruce Springsteen’s lyrics had upon him. The film stars Kulvinder Ghir, Hayley Atwell, Rob Brydon, Sally Phillips and newcomers Viveik Kalra and Nell Williams.
“An exuberant anthem to the importance of music, the need to be seen and the hope of new possibilities” – EMPIREFind your local Picturehouse and book tickets now.
Playmobil: The Movie
When her younger brother Charlie (Gabriel Bateman) unexpectedly disappears into the magical universe of Playmobil, Marla (Anya Taylor Joy) must go on a quest of a lifetime to bring him home. As she sets off on a fantastical journey through a vibrant new realm, Marla teams up with some unlikely and heroic new friends, including the smooth-talking food truck driver Del (Jim Gaffigan), the dashing and charismatic secret agent Rex Dasher (Daniel Radcliffe), a wholehearted misfit robot, and an extravagant fairy-godmother (Meghan Trainor). On their adventure, Marla and Charlie realise that, no matter how life plays out, you can achieve anything when you believe in yourself and harness the power of imagination.Book your tickets now.
Dora And The Lost City Of Gold – MediCinema Previews Sun 11 Aug
This live-action reimagining of one of Nickelodeon’s most popular pre-school cartoons fast-forwards to the teenage years of the iconic young explorer. Now Dora (Isabela Moner) faces her most dangerous adventure yet: high school. As intrepid as ever, she ends up leading Boots (her best friend, a monkey), Diego (Jeffrey Wahlberg), a mysterious jungle dweller (Eugenio Derbez), and a ragtag group of teens on a quest to save her parents (Eva Longoria, Michael Peña) and solve the mystery behind a lost city of gold.
In aid of MediCinema. Find out more at medicinema.org.ukBook your tickets now.
Pain & Glory – Exclusive Previews Sun 11 Aug
In Almodóvar’s deeply personal and tender new drama, a film director reflects on the choices he’s made in life as past and present come crashing down around him. Salvador Mallo (Antonio Banderas, who deservedly won Best Actor at Cannes Film Festival for his performance), an ageing Madrid-based auteur, is retreating into himself, facing ill health, depression and the decline of his powers. After a chance meeting reunites him with an actor from his past, a wild new chapter begins, sparking a series of reconciliations and reveries in which Salvador revisits old emotional wounds and tries to piece together the puzzle of his life and his art.Book your tickets now.
Goodfellas – EMPIRE 30/Vintage Sundays, 11 Aug
Based on Nicholas Pileggi’s book Wiseguy, Martin Scorsese’s mob-movie masterpiece – starring Robert De Niro, Joe Pesci and Ray Liotta – marked a revival of Hollywood interest in gangsters and gangsterdom. It chronicles three decades of a life in crime, following Brooklyn youngster Henry Hill’s graduation from petty criminal to big-time thief. Widely regarded as one of the greatest films in the crime genre, this is essential viewing for any movie fan.Book your tickets now.
Apocalypse Now: Final Cut – Tues 13 Aug
Forty years after its original release, Francis Ford Coppola’s Apocalypse Now returns to cinemas looking and sounding better than ever. Restored from the original negative to the highest audio and visual standards by the director himself, Final Cut is Coppola’s preferred and most visceral version of his Oscar-winning Vietnam War epic. This never-before-seen cut features only some of the footage added back into the Redux release, bringing the runtime to just a shade over three hours.
This screening includes a Q&A between Coppola and director Steven Soderbergh, recorded at the Tribeca Film Festival in April, in which they reflect on the film’s legacy in light of its 40th anniversary, and the long journey to creating this new restoration.Book your tickets now.
Once Upon A Time… In Hollywood – From 14 Aug
Quentin Tarantino’s ninth film visits 1969 Los Angeles, where everything is changing, as TV star Rick Dalton (Leonardo DiCaprio) and his longtime stunt double Cliff Booth (Brad Pitt) make their way around an industry they hardly recognise anymore. The writer-director’s latest work features a large ensemble cast and multiple storylines in a tribute to the final moments of Hollywood’s golden age.Book your tickets now.

domain: entertainment


text: Irina Savelieva (RAS): In Search of the New "Turns": History and Theory in the 21st Century. From World History Connected, a special issue on the environment in world history. Telling Time: William Grassie on a correlated history of the universe. An interview with Sanjay Subrahmanyam on how history cannot be written as if nations had always been around. From The University Bookman, a series of essays focusing on the life and achievement of historian John Lukacs. How a historian who reveled in destroying the reputations of others ruined his own: A review of An Honourable Englishman: The Life of Hugh Trevor-Roper by Adam Sisman. Baffled by the ease with which titles promising to turn world history on its head have won huge audiences despite defying logic and lacking proof, Daniel Melia laboured to divine the hidden secrets that allow anyone to identify truly "bad books". History, sired by literary nomads: Raju Peddada on how itinerant scribes of antiquity drafted historiography (and part 2). Geoff Dyer on different ways of writing history and examples where innovative or experimental approaches have paid off.

domain: literature


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Small Dog Adoption Process
How does our small dog adoption process work?
There are four basic steps:
- Complete the adoption application form
- Home check and interview
- Adoption fee
- Adoption contract
How much is the adoption fee?
Our standard fees typically range between R600 to R1600.
Please note that adoption fees may be higher for special or high-demand breeds.
What does the adoption fee cover?
Our minimal adoption fee covers outreach costs and is intended as a donation toward the rescue work of Little Doggy breeds around South Africa. Our goal is to find the best homes for each dog in need, focusing on their individual needs. The adoption fee is therefore an important part of all adoptions.
Why choose to adopt a small dog from Little Doggy Rescue?
- Little Doggy Rescue is a home-to-home small dog adoption service in South Africa.
- We believe that every Little Doggy deserves a loving home, and that is why we work tirelessly to find them the perfect forever homes.
- We do not want our small dogs to spend one night in a shelter or kennel environment, so we provide a home-to-home service instead.
- This means that we will help you find your Little Doggy the perfect forever home, and we will take care of all the necessary paperwork and vetting processes.
If you would like to adopt a Yorkie please visit SA Yorkie Rescue for available adoptions

domain: pet


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November 2, 1967
|Birthplace||Nisshin, Aichi Prefecture, Japan|
Other roles of his include Athrun Zala in Mobile Suit Gundam SEED, Gaara in Naruto, Kaworu Nagisa in Neon Genesis Evangelion, Katsura Kotarou in Gintama, and Chou Hakkai in Saiyuki!.
He has also done work with video game voicing, dubbing, tokusatsu, and drama CDs.
- His blood type is O.
- His height is 163cm or 5'3".


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Baseball is my absolute favorite sport, and I can watch any game that’s on TV, no matter who is playing. I’m planning on watching the Cubs’ championship parade this morning with my dad, which will be a lot of fun, mostly because I never thought in my entire lifetime I would live to see it. I think what I love most about baseball is that unlike hockey, football, or basketball, there is no clock. An inning can take 5 minutes or it can take 50 minutes. It could end in 9 innings or 20. The other sports are divided into quarters or periods and each quarter or period lasts a specific amount of time, and that’s it. Overtime is a specific amount of time, and that’s it. It’s also the only sport where the defense has the ball. It’s a game of one-on-one moments between the pitcher and batter that ultimately benefits an entire team.
When people say baseball is boring or they don’t get it, I wonder what they’ve been watching, because it couldn’t have been baseball. Baseball is anything but boring. Does it have the flash or speed of hockey? No, innings can sometimes crawl by at a glacial pace, but there’s so much nuance and excitement in a runner on base, wondering if he’s going to steal, if the batter will bunt or swing away…I love it. I’ll always love it.

domain: sports


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We're only three weeks away from my 30th birthday. Since I'm celebrating my birthday over three weekends I figured I'd celebrate with you by doing a CELEBRATION GIVEAWAY!!
This isn't just A giveaway... this is THREE giveaways in one! (Do you see a theme going here?) So let's get started with what I'm giving away and will discuss more details at the end.
The first is a book I've been reading that is just too good not to share! "How To Be a Woman" by Caitlin Moran, may make some nervous with reclaiming the word feminism, but the reason I love Caitlin is because she has a way of telling her story, telling my story, telling OUR story and helping make women realize that feminism isn't a word to be frightened of but to embrace and reclaim.
"Any action a woman engages in from a spirit of joy, and within a similarly safe and joyous environment, falls within the city-walls of feminism. A girl has a right to dance how she wants, when her favourite record comes on.” ― Caitlin Moran, How to Be a Woman
Jenny Lawson raves about her (I didn't notice review on the back of the book until I was getting ready for this giveaway)...so if you love the Bloggess you know that she gives Caitlin a thumb up!
For my readers who connect with me more on the getting dressed up and stepping out level. I have this beautiful cameo necklace on ribbon for you. I was given this necklace a few years ago and I've been meaning to put it on a longer ribbon (too short for me) and just never have. So instead of having it hang on my wall for another year I thought I'd share it with my lovely followers.
Last but far from least is a block printed (original) reusable tote bag from fellow artist, blogger and my dear friend iz originals. It's perfect for books, taking to work, reusable grocery bag (that's the Portlander in me) and I do love supporting artists.
She has a few prints with this same design on it and I got lucky enough to have iz love me enough to send me a print. Can't wait to put it up in my office.
Because this is my birthday we're doing away with (most) the rules! Everyone and anyone is eligible to win (even if you've won a giveaway with me before, even if we know one another in real life, and even if you aren't a follower here on Blogger!)
Only Rule: I do ask that if you any (or all) of the giveaways you either email me at email@example.com with the best email to contact you at or you leave a comment below with preferred method (facebook, twitter, email). I will attempt to contact the winners on Sunday, February 3rd and will allow one week for response. Otherwise I'm going to select another winner.
So have fun and nter often (if you tweet about the giveaway every day you can earn more points). Recommend and share with your friends (who knows maybe they'll regift the gift to you for being such a good friend).


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Essential for the growth and repair of body tissues
Protein-rich foods include: Meat, chicken, fish, eggs, cheese, yoghurts, nuts, pulses, meat substitutes (Note: some high protein foods contain high levels of phosphate and potassium)
Recommendation for protein varies according to stage of renal disease/ type of renal replacement therapy.
|Pre dialysis/ Conservative Management
Controlled protein intake (0.8-1g/kg/IBW)


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In the early 90s I was working for Digital Equipment Corporation (once over 130,000 employees, now no longer exists), and during a trip to Palo Alto a friend of mine working for their Western Research Lab showed me a demo of an early Internet browser (xmosaic) when at that point the Wide World Web consisted of six demo web sites. I’d like to say that I thought of then someday starting a crime fiction web-site, but my thoughts were more business oriented—I considered at that time buying a Cisco router, a workstation, and starting what would’ve been one of the first ISPs and dedicating it to field service personnel, something that would allow them to access technical manuals anywhere they had access to the Internet. If I had done that I’d be very wealthy right now, but I chickened out. But a few years later as the web became more popular I started thinking of building a crime fiction web-site, and in 2002 I started Hardluck Stories. The name originated from my novel, Fast Lane, where early on I have a street pimp named Rude complaining to celebrity detective, Johnny Lane, about his newspaper column which details his PI exploits:
“Maybe I should talk to your editor. If he’s going to publish crap like ‘Fast Lane’, maybe he’d be interested in something good. Something real. The Rude Streets, stories of the Hardluck.”
Originally Hardluck was a site to promote hardboiled and noir books. Each book on the site had links to an author-written essay about the book—why the writer wrote it, what inspired it, etc., and a short story by the author. This concept would allow readers to discover new writers by reading these essays and short stories. I had a dozen or so authors participating in this, but it didn’t take off the way I had hoped, and eventually the site mutated to a quarterly hardboiled/noir fiction web-zine whose six-year run has just ended. My reasons for starting Hardluck were varied—it was partly to help me promote my self-published book, partly to give myself a creative outlet since I wasn’t having much luck at that time finding a publisher for my books, and partly to help out newer writers like myself. What differentiated Hardluck from the other web-zines and publications, at least at that time, was that I was going to be using a different guest editor for each issue. I had several reasons I wanted to do this: 1) so that the web-zine wouldn’t become cliquish, which I was noticing with some of the crime fiction web-zines back then—I wanted to make sure mine would be fair and not just me publishing friends 2) I wanted to keep the web-zine fresh and introduce ideas that I might not have thought of myself 3) I had gotten to know Vicki Hendricks through her guest-editing an issue of PlotsWithGuns and picking one of my stories, and I wanted to create the same type of situation for other guest editors and newer writers. I think it was due to this constant injection of new ideas from my guest editors and fairness in selecting submissions that caused Hardluck to increasingly get better submissions, to where in my opinion Hardluck was consistently putting out one of the highest quality short crime collections I’ve seen either on the web or in print.
In some ways starting Hardluck contributed to my first book escaping the stench of self-publishing and ending up with Point Blank Press. In a lot of ways this is one of those space-time continuum thingies that they’d have on Star Trek and other sci-fi shows. While I was doing this I got to know another frustrated noir writer—Allan Guthrie, and I ended up publishing his first short story, as well as the two of us showing each other our unsold novels and other works and trading ideas about them. That first publication of Al’s story triggered others, and the next thing I knew he was starting up what became Point Blank Press with JT Lindroos, and the first book Al commissioned was In His Shadow, which wisely had it’s name changed to Fast Lane. So I published Al’s first story and he published my first book—while I had sold the Italian rights to In His Shadow first to Meridiano Zero, Point Blank beat them to the punch by publishing their version several months before the Italian version was out.


KARACHI: Sindh Governor Imran Ismail on Thursday said the Green Line buses will start their operation in Karachi from December 25.
Addressing media in Karachi, flanked by Federal Minister for Planning and Development Asad Umar, governor Sindh said Prime Minister Imran Khan would inaugurate the Green Line Bus Rapid Transit (BRT) project on December 10.
“The buses will first run on a trial period in the city for 15 days,” he said adding that despite the coronavirus situation, buses would start their operation on time.
For the last 13 years, the Pakistan Peoples Party government had not given even a single bus to the megalopolis, he added.
Planning Minister Asad Umar said the federal government had taken up five mega projects under the Karachi Transformation Plan in September last year.
“Solid development is being made on other four mega projects of the metropolis as well which are being developed by the federal government,” he said.
He apprised media that foreign companies were also taking interest in the Karachi Circular Railway (KCR) project. While, he said, the bulk water project, K4, will be completed by September 2023. Under the K4 project, the city would be provided 260 million gallon water, he maintained.
Asad Umar said the centre had cleaned three big nullahs of Karachi. Work on Mehmoodabad nullah had been completed and it would be opened in the next two months.
The federation had fulfilled its responsibilities, he said.


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BY WIL CREWS
In her sixth year as head coach of the Beauregard varsity volleyball team, Kathy McDonald and the Lady Hornets have won the regular season Class 5A Area 5 title.
The No. 1 finish in the area — which consists of the Hornets, Eufaula and Valley — is the highest Beauregard has seen since McDonald’s second year, where her team finished second in the area and advanced to regionals.
This season, the Lady Hornets have just one senior in their squad. Despite a lack of experience at the high school level, McDonald saw the potential in her team early on.
“I had hoped [we] would have a good season,” she said. “This was the first time that I have had multiple players play club volleyball in the offseason, and I definitely think that helped lead our team.”
McDonald gleaned the contributions of everyone on her team but said the squad has leaned on a trio of junior standouts: Katie Wilkerson, Ashlyn Watson and Cooper Watson.
Wilkerson has 191 kills thus far this season, and Ashlyn and Cooper both sit at 148 kills apiece.
“Obviously it takes the whole team to be successful, but I have three hitters who have contributed for decent kills when we needed them,” McDonald said.
Furthermore, defensively, sophomore Abby Jones led the team in digs with 218.
As the Lady Hornets now turn their attention to post-season area and regional tournaments, McDonald is trying to continue to build momentum with her squad.
One instance in a recent tournament at Central Phenix City confirmed to the head coach that her team is still headed in the right direction.
“All I did was ask them to play better, and they did,” McDonald said. “I want them pushing and giving everything they have, not holding back, not having any regrets and knowing they put it all out on the table.”
The Lady Hornets have three remaining regular-season matchups to play before the area tournament begins on Oct. 12. Make no mistake, Beauregard aims to win it.
“We are hoping for first place to be a little bit better seed for regionals,” McDonald said.

domain: news


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Dubai, UAE 6th of April 2017 – Careers UAE 2017 will be taking place at Dubai World Trade Center from the 9th of April until the 11th of April 2017. Akhtaboot is taking part at this event as “Recruitment Solutions Partner”.
The event is organized by Dubai World Trade Center in conjunction with TANMIA, Higher Colleges of Technology and UAE University. Careers UAE provides a platform that enables talented UAE nationals in different fields and sectors to meet up with leading employers offering different employment opportunities. In addition to the training, education and employment opportunities that will be given to job seekers, UAE nationals will also be able to attend a host of inspiring and informative free seminars to enrich their skills and be more prepared to the job market.
Akhtaboot is always keen on taking part as a “Recruitment Solutions Partner” of such events that empower UAE nationals as well as contribute to filling unemployment gaps in both the Gulf and Middle East Region.

domain: economics


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WHO IS SHE: Comic veteran Joan Rivers has enjoyed a diverse and immensely successful career which has spanned four decades. “The Queen of the one-liners” as she is sometimes referred, has won a Daytime Emmy Award for Best Talk Show Host, and was nominated for a Grammy Award for Best Comedy Recording in 1985. She was also nominated for a Tony Award in 1994 for her lead role in “Sally Marr…and Her Escorts.” The Brooklyn, N.Y., native is also famous for her runway interviews and commentaries at major award ceremonies.
- Today's Top Stories
- Breaking News
- Casinos & Tourism
- ►Reinventing A.C.
- The Trump Files
- Miss America
- High School
- Auto Racing
Kingfish are becoming a significant presence on a fishing scene that already includes sometimes spectacular tuna fishing inshore and consisten…
HAMMONTON — You binge-watch TV shows, right? Why not do the same thing with theater?
Harley Quinn #1: Harley's back ... not that she was gone, really. The star of Friday's "Suicide Squad" movie goes back to issue #1 by defendin…
SAN JUAN, Puerto Rico (AP) — Puerto Rico's governor has signed a bill letting the island's 78 municipal governments share administrative servi…
- At The Shore
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domain: celebrity


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RSS feeds let you create automatic alerts, based on your criteria, that inform you of new research published in your field.
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domain: library


text:
The Natural Gourmet Institute (NGI) has trained new and young chefs for nearly 40 years. More than 2,500 chefs from over 45 countries have graduated from NGI’s health-supportive culinary education program, including Bryant Terry, author of Afro-Vegan: Farm-Fresh African, Caribbean, and Southern Flavors Remixed; Amanda Cohen, founder of award-winning restaurant Dirt Candy; and Alexandra Jamieson, author and activist.
Every Friday night in New York City, students and instructors from NGI’s Chef Training Program prepare a family dinner using seasonal, local, fresh, traditional, and whole ingredients. Food Tank has the honor of being NGI’s community partner for the entire month of May. Tickets are US$45 and can be purchased here; dinners are BYOB. Ten percent of proceeds from May’s Friday Night Dinners will benefit Food Tank.
Sample dinner menu for Friday, May 8:
This will be a buffet-style ramen party. The menu was developed by Chef Hideyo Yamada and is gluten-free.
- SOUPS: Goma miso soup and shoyu soup
- NOODLES: Thin rice noodles and ramen noodles
- TOPPINGS: Stir-fried spicy cabbage with shimeji mushrooms, steamed baby bok choy with sesame oil, hard-boiled eggs, marinated tofu with Chinese five-spice sauce, and tender fish balls
- SIDES: Baba ghanoush with rice crackers; Asian-spiced mixed nuts
- DESSERT: Strawberry mochi ice cream, black bean brownie

domain: food


text:
Mutant SOD1 protein increases Na(v)1.3 channel excitability
AuthorKubat Öktem, Elif
Kobertz, William R.
Brown, Robert H., Jr.
MetadataShow full item record
CitationKubat Öktem, E., Mruk, K., Chang, J., Akın, A., Kobertz, W. R. ve Brown, Robert H., Jr. (2016). Mutant SOD1 protein increases Na(v)1.3 channel excitability. Journal of Biological Physics, 42(3), 351-370. https://dx.doi.org/10.1007/s10867-016-9411-x
Amyotrophic lateral sclerosis (ALS) is a lethal paralytic disease caused by the degeneration of motor neurons in the spinal cord, brain stem, and motor cortex. Mutations in the gene encoding copper/zinc superoxide dismutase (SOD1) are present in similar to 20% of familial ALS and similar to 2% of all ALS cases. The most common SOD1 gene mutation in North America is a missense mutation substituting valine for alanine (A4V). In this study, we analyze sodium channel currents in oocytes expressing either wild-type or mutant (A4V) SOD1 protein. We demonstrate that the A4V mutation confers a propensity to hyperexcitability on a voltage-dependent sodium channel (Na(v)1.3) mediated by heightened total Na+ conductance and a hyperpolarizing shift in the voltage dependence of Na(v)1.3 activation. To estimate the impact of these channel effects on excitability in an intact neuron, we simulated these changes in the program NEURON; this shows that the changes induced by mutant SOD1 increase the spontaneous firing frequency of the simulated neuron. These findings are consistent with the view that excessive excitability of neurons is one component in the pathogenesis of this disease.


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First off, check out the new photos from SNSD and 2PM‘s new CF for Caribbean Bay. These are only teasers for the CF, but it’s pretty dark looking…
Lee Min Ho starred in a CF for Banana Milk, and the way he’s going about endorsing it makes me really want to try it! There are four versions of the CF, which you can check out here.
Gummy recently released her new mini album Loveless, and a new MV for “As a Man,” starring Jung Ryeo Won and Kim Hyun Joong. It’s a very sweet story, and borders on heartbreaking because I can almost identify… and well, I’ll let the MV speak for itself
In my missing Prosecutor Princess, I looked up to see if Park Shi Hoo had any MV’s to help sate my desires… and thank goodness he appeared in Taru‘s song 예뻐할께 for Color of City! Now if only he’d act like that with Kim So Yeon…
The “prequel” to the above song is by Kim Bum Soo called “Taste of Separation”
And then because I was looking for Park Shi Hoo…I decided to look for some of my other fave actors in CF’s – and I found Park Shin Hye in Taegoon‘s “Call Me” – ridiculously old because it came out last year. Oh well – better late than never!
But this is the best I could do for Kim So Yeon:
It comes from the charity album for the Love Tree Project.
source: youtube, omgkpop


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Rover Group P.L.C., aided in part by American sales of its Sterling car, said it reduced its after-tax loss by 80 percent in the first half of the year from a year earlier.
The state-owned auto maker said today it lost $:42 million, or the equivalent of about $66 million at present exchange rates, in the year’s first six months, compared with a loss of $:204.5 million ($321 million) in the first half of 1986.
Group losses before interest and taxation were $:7.3 million ($11 million), compared with $:71.1 million ($112 million) in the period a year ago.
Revenue rose 26 percent, to $:1.58 billion ($2.5 billion), from $:1.25 billion ($2 billion). The group’s production rose to 246,000 vehicles this year from 242,000 a year ago, while sales were up to 259,000 vehicles from 233,000.

domain: finance


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Rail Pollution-Legal Action?
In a report commissioned by Stirling Council, Noise and Vibration Consultants, Sandy Brown Associates, reported that night noise levels were, in their opinion, a ‘statutory nuisance’. A Statutory nuisance is a legal term for pollution that is judged to be a ‘nuisance’ or ‘prejudicial to health’. Once classified as a ‘statutory nuisance’, UK environmental law says abatement orders should be served (EPA1990,sec79,80).
Link to railway noise vibration report
How Bad Is It?
Noise at four out of five sample residential locations was
measured to be far higher than night background levels, and many times louder than the 60dBlamax level advised by the World Health Organization. Some events were as much as 30dB higher than WHO’s health-based guideline of 60dBlamax. The higher the noise above the advised level the greater the impact on health. With as many as fourteen noise events per night well above the maximum advised by the World’s most eminent health authority, it’s reasonable to conclude that the situation is ‘prejudicial to health’.
What About Vibration?
One of the five sample sites was found to be in the highest of three night time ranges specified by British Standard BS6472 and deemed likely to cause adverse response. At four other sample locations vibration levels were not found to be excessive however residents report that the rail vibration is highly variable and the report can only comment on what was found during the monitoring period.
Even at Low Speed
Accompanying the noise and vibration report are Council commissioned train speed reports. These show just how slowly trains were travelling during the monitoring period. Speeds allowed by Network Rail along this line are 60mph for freight and 70mph for passenger trains, yet during the monitoring period speeds were much lower, sometimes barely above 20mph. Very few got into the low 50s. Apparently the Council asked Network Rail about what was happening with speeds on the line but, despite claims by Network Rail that they work closely with Councils, no information was forthcoming.
NHS Action, Council Action
The Council are seeking legal advice before acting however, as ‘statutory nuisance’ is, according to DEFRA and legal rulings, the trigger for serving of abatement orders, not the start of deliberations or negotiation, it is expected that this will be soon.
NHS Forth Valley have important public health obligations, including to advise the public on health risks, to address environmental issues such as pollution and to tackle health inequality. As yet they’ve made no public statement and have given no advice to residents on this issue. Perhaps NHS Forth Valley will say something at the Annual Review of NHS Forth Valley’s performance during 2013/14, an event open to the public which will take place on Friday 28th November 2014 from 2 – 4pm in the Lecture Theatre on the third floor of Forth Valley Royal Hospital.
Related Articles and News Coverage
The BBC ran an article 17Nov 2014
Study finds Stirling freight trains cause ‘major disturbance’
Scotsman newspaper ran an article (no link at present)
Stirling Observer newspaper is to run an article probably 18th or 20th Nov
World Health Organization report- Burden of disease from environmental noise – Quantification of healthy life years lost in Europe


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Author Stanley Kurtz has released new information, confirming that, despite Obama campaign denials, Barack Obama was a member of the Chicago New Party, in 1996.
There is also documentary evidence that Obama was not only an active member, but a leader of a New Party sister organization Progressive Chicago, as far back as 1993.
Furthermore, there is ample evidence that the New Party/Progressive Chicago was set up by Marxists, for Marxists, in order to increase far left influence in the Democratic Party, and eventually establish a leftist major party to replace the Democrats entirely.
Strong in the mid to late 1990s, the New Party was an electoral alliance dedicated to electing leftist candidates to office – usually through the Democratic Party.
Two organizations formed the backbone of the New Party – the Democratic Socialists of America and the US’ then largest radical organization, ACORN. Radical labor union SEIU also had considerable input, as did members of the Communist Party USA spin off, Committees of Correspondence. DSA had infiltrated ACORN, SEIU and Committees of Correspondence, so arguably the socialists were the real power behind the New Party.
Elaine Bernard and Kurt Stand of Democratic Socialists of America, and Judy Page of the New Party were speakers on the Towards a New Party panel sponsored by the DSA at the Tenth Annual Socialist Scholars Conference, held April 24-26, 1992 at the Borough of Manhattan Community College, New York City.
Bernard and Page were later active in the New Party, while Stand was later jailed as an East German and Soviet spy.
Barack Obama, incidentally, used to attend the annual Socialist Scholars conferences, while studying at Columbia University in New York in the early 1980s.
In Chicago, the New Party founded an equally radical “sister organization,” Progressive Chicago….
…read it all…

domain: politics


text:
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Thirumathi R. Shantha
Kapildev, Sulakshna... more
Andha Rathiriku Satchi Illai is a tamil movie, directed by R. Sundarrajan, starring Kapildev, Sulakshna along with others. Here, on the movie page, you will find every thing that you need to know. Check out what others are saying about the movie on twitter.
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It looks like Roddy Ricch is prepping his new album.
The 23-year-old rapper released his first album Please Excuse Me For Being Anti-Social two years ago and its safe to say fans are eager for more.
Yesterday, Roddy, informed fans that his first album has officially been on the Billboard 200 charts for 100 weeks and declared that it's time to freshen things up.
"All my fans GOATS" Ricch Tweeted. "It's time for another one."


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The Kimberley's senior paediatrician says an urgent study is needed to establish the number of children affected by prenatal alcohol disorders.
Dr John Boulton says he works with other doctors, nurses and Aboriginal health workers who believe one in every three children in Halls Creek and Fitzroy Crossing are affected by the disease Foetal Alcohol Spectrum Disorder.
It is an umbrella term used to describe the range of disabilities associated with prenatal exposure to alcohol.
Foetal alcohol syndrome - which can cause facial abnormalities and learning difficulties - is the most readily recognised disease.
Dr Boulton says urgent action must be taken to stop Indigenous mothers drinking during their pregnancies.
"The high level of alcohol abuse in Indigenous communities is a public health tragedy," he said.
He says the inter-generational effects of alcohol abuse will continue if nothing is done.


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Tactical Studies Rules was formed in 1973 as a partnership between Gary Gygax and Don Kaye as a means to publish formally and sell the rules of Dungeons & Dragons, the first modern role-playing game. The partnership was subsequently joined by Brian Blume and (temporarily) by Dave Arneson.
In 1975 Don Kaye died, the partnership was dissolved and the remaining owners incorporated a new company TSR Hobbies, Inc..
In 1983, the company was split into four companies, TSR, Inc. (primary successor), TSR International, TSR Ventures and TSR Entertainment, Inc..
TSR, Inc. was purchased in 1997 by Wizards of the Coast, and finally, in 1999, this one was also purchased by Hasbro, Inc..
First logo of the company, during 1974-1979, was a symbol made by letters G and K for Gary Gygax and Don Kaye.
was the portion of TSR that published Dragon Magazine and related products, such as Dragontales, calendars, etc. Dragon Publishing was also the US distributor for The Wargamer and White Dwarf.

domain: hobby


FONTANA – An alleged sexual predator was arrested on Thursday morning Fontana Police officials said.
A joint investigation by the Fontana Unified School District Police, Detectives from the Fontana Police Department’s Internet Crimes Against Children Task Force revealed the 20-year-old Benny Kim was communicating with a 14-year-old girl. Authorities said that the two communicated over social media sites, through text messages, and phone calls.
In addition to the communication, Kim sent inappropriate sexual images of himself to the minor and requested she did the same of her completing various sexual acts. Authorities said that the girl was sexually assaulted.
Kim was taken into custody while visiting the City of Fontana and was booked into the West Valley Detention Center for sex with a foreign object with a victim under 18, sodomy with a person under 18, oral copulation with a person under 18, and sex with a minor 3 or more years younger. He is being held in lieu of $100,000 bail and is scheduled to appear at the Rancho Cucamonga Superior Court on Monday.
- Job and Education Fair with Expungement Services Coming to Hesperia - Wednesday, September 15th, 2021
- Man Located Deceased Near Hesperia Railroad - Wednesday, September 8th, 2021
- Man Arrested for Vandalism of Rancho Elementary in Temecula - Wednesday, September 1st, 2021
- benny-kim: Image Courtesy of Fontana Police Department


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Once again, low-income seniors in Stanislaus County can get $20 worth of coupons for select farmers markets.
The coupons can be picked up at markets in Modesto, Patterson and Riverbank on three days this month. They are available to residents 60 and older who have annual incomes of up to $1,799 a month for a one-person household or $2,425 for two.
The coupons can be used to buy fresh fruit, vegetables, herbs and honey. They are issued only once a year on a first-come, first-served basis.
The Area Agency on Aging announced this schedule:Patterson:
The funding comes from the Senior Farmers Market Nutrition Program of the U.S. Department of Agriculture, which aims to get older people to increase their intake of fruits and vegetables. More information is at (209) 558-8698.
Participants may drive to the five stops in any order after buying tickets, which are $8 in advance or $10 that day. Those 18 and younger get in for free.
The sites are the Lazy G Bar Ranch, which has horses; Deer Creek Cherry Farm; Mountain Sage Nursery; Big Creek Meadow Ranch, which has sheep; and Red Tail Ranch, an egg producer.
Farms of Tuolumne County is a nonprofit group that promotes agriculture in this area. It has long been dominated by beef cattle, but diversified ventures now dot the landscape.
The tour is close to where the Rim fire burned last year, and another chance for the county’s tourism sector to rebound from recent tough times.
More information is at (209) 928-3775 or www.tcfarms.org.


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Miguel came through to the Upstate Concert Hall last night and shut it down. I honestly forgot how many Miguel songs I truly loved. He is such a great artist and an even better performer. He played all his hit songs from "Do you" and " Coffee" to "Adorn" and " Simple Things". Of course he ended the show with his hit single that's out now " Skywalker&q
The R&B game this year was filled with breakthrough efforts, trap-soul introductions, vintage soul debuts and classic albums from your favorite artists. So we compiled a list of the Best R&B Albums of 2015.
The 2015 MTV Video Music Awards is being presented live from Los Angeles at the Microsoft Theater. But before the show gets underway, the hottest superstars in hip-hop and R&B hit the red carpet to show off their best ensembles.
The road to the release of Miguel's upcoming album, 'WILDHEART,' is coming to an end. We've already heard a number of tracks including "Coffee," "NWA" and "Hollywood Dreams," and now, he's debuting three more songs.
Ever give your morning coffee a shot of whiskey? That'll be sure to give you a buzz all day long! That's what R&B singer Miguel is up to teaming up with Jack Daniels for his new single "Coffee".
It’s been two years since Miguel released his Grammy-nominated album, ‘Kaleidoscope Dream,’ but he’s been keeping himself busy in the studio. On Friday (Dec. 19), the R&B loverboy surprised fans by releasing three new songs.
With the beginning of cuffing season underway, Ludacris releases a tender rap ballad called 'Good Lovin'' that will certainly appease the ladies. The song, which features the velvety voice of Miguel, reveals the softer side of Luda as he reflects on the ups and downs of love.
DJ Prostyle of New York City's Power 105.1 celebrated his birthday in true hip-hop fashion last night (April 30) at the Best Buy Theater in Times Square. The radio jock chose to party with hundreds of fans and even shared his gift with them -- performances by 2 Chainz, Miguel, Ne-Yo, Sean Paul and Omarion.
Miguel has teamed up with Wale to rework Elton John’s classic pop song 'Bennie and the Jets.' The duo's cover tune will appear on the "Super Deluxe" reissue of John's 1973 album, 'Goodbye Yellow Brick Road,' which drops on March 25.
R&B singer Miguel recently pleaded no contest to the charge of DUI, which stems from his traffic arrest back in August 2013. The 28-year-old artist was remorseful during his court appearance last week where he admitted that he made a terrible mistake.
Before gearing up for the 2014 NBA All-Star game in New Orleans, Miami Heat superstar LeBron James partied like a rockstar with Rick Ross, Miguel, Black Thought and the Roots at his NBA All-Star Party on Saturday night (Feb. 15).


Received Date: March 25, 2017 Accepted Date: April 03, 2018 Published Date: April 07, 2018
Citation: Jadhav S, Date P, Singh R (2018) Effect of Ni to Cu Ratio on Formation of Oxide Scale at High Temperature. J Nanosci Nanotechnol Res Vol.2: No.1: 3.
Metals, which are especially used in the hot forging applications, are stable, when exposed to the atmosphere, at high and low temperatures. Metals such as iron, rusts and get oxidised very rapidly, while the other metals such as nickel, chromium corrode relatively slowly. Therefore it is important to study oxidation process along with film thickness of the oxide layer. The role of various alloying elements and its oxides during oxidation process need to be understood. Copper strongly influences the microstructure of micro alloyed steel since segregation of Cu occurs in steel during oxidation. Samples containing various Ni/Cu ratios are studied in SEM & XRD. Four samples of ratio of 1.8, 2.0, 2.5 and 5.0 with dimension size 25 mm × 25 mm are studied. The sample which has ratio of 1.8 gives better results since it shows minimal severity in cracking and optimum thickness is achieved.
Oxide scale; Ni to Cu ratio; XRD; SEM; Oxide scale thickness
Use of recycled scrap in manufacturing industries becomes necessity for the sake of recycling and this leads to degradation in quality of steel. Residual or tramp alloying element such as Ni, Cu, S are difficult to remove during production of steel .
This mechanism is termed as hot shortness. In the hot shortness phenomena, Copper oxidizes rapidly than Fe at high temperature and enriches at scale/metal interface. When Cu exceeds its solubility range in austenite, a liquid Cu penetrates into austenite grain boundaries and causes cracking during forging .
Nickel causes surface defects on the steel. As small as 0.1% Ni causes iron oxide on the surface of steel . Copper and nickel element in the surface of the steel during hot rolling causes surface defects. Therefore, it is important to understand and control the behavior of the distribution of these elements.
Alloying Nickel is beneficial for special purpose since Ni increases the scale adherence with low free oxygen. Ni containing steel when exposed at high temperature contains two types of scale, i.e., inner scale and outer scale. But, after air cooling some part of outer scale spalls off and inner scale remains intact with steel surface which increases 3% to 5% adherence of scale . However during manufacturing process scale which is formed on steel during reheating is hard to remove. Most of times steel has tendency to form different oxide layers at high temperature.
The thickness of these layers goes on increasing at high temperature which then degrades the quality of final product. Similarly, on other hand Cu also plays an important role in corrosion resistance along with little adverse effect on steel surface such as cracking of surface at high temperature .
Copper causes serious problems such as cracking of steel surface during forging and rolling. Copper also segregates to MnS inclusion exacerbating the problem of segregation . Nickel has tendency to enrich near scale metal interface . It is also known that copper precipitates in the steel as CuS precipitate which reduces the ductility .
Recent works have reported that combine addition of Copper and Nickel encourages the grain coarsening in micro alloyed steel. However the addition of Nickel has been reported as most important, because it increases the solubility limit of copper in austenite to surpass the problem of surface cracking .
Thus the effect of Cu and Ni on the surface cracking of steel at high temperature with oxidation has been investigated. Moreover microstructure and composition of phases formed at scale/metal interface were investigated. Therefore, this study is related to various Ni/Cu ratio at high temperature in detail. This paper investigates the composition of phases formed on steel, and effect of Ni/Cu ratio on scale adherence. This study also reveals the optimum Ni/Cu ratio in the micro alloyed steel .
Steel with four different ratios of Ni/Cu were cut to size of 25×25 mm taken for the study. The chemical composition are shown in Table 1
Table 1: Chemical composition of micro alloyed steel (mass %).
These four samples of steel were taken for oxidation study. Heat treatment were carried out on all samples. The samples were heated at 115°C in an atmosphere of 2% O2 +12% H2O with 1 hr soaking time followed by air cooling. After heat treatment on the samples, scale formed during air cooling was collected for further examination. Microstructure at scale/ metal interface after oxidation were observed using Scanning electron probe micro analysis (SEM), energy dispersive spectrometer (EDAX). Smaples were taken for X-ray diffraction (XRD) for the phase analysis.
A cross sectional SEM image of steel with four different ratios of Ni/Cu after oxidation has been studied. The SEM images of scale metal interface in the various Ni/Cu ratio of micro alloyed steel oxidized at 1150°C are shown in the Figure 1. As metallic phase were occlude into scale, the interface became uneven and cracking took place as result of presence of high Ni/Cu ratio. Internal oxidation also occurred in the fracture surface.
Thickness and unevenness of oxide scale formed on the surface of steel containing Ni/Cu ratio 5 is higher as shown in Figure 2. It has been found that oxidation takes place exactly at inner/outer scale metal interface where porosity and cracking is more sever. It has been concluded that severity of cracking is more when ratio is more as the result of oxidation. Spectrums processing in Table 2 shows total 100% and standard element detected are as follows to form different oxides in the scale such as iron oxide chromium oxide, nickel and copper oxides.
Table 2: Spectrum processing of steel with Ni/Cu=2.5.
Spectrum processing in Table 3 shows total 100% and standard element detected to form different oxides in the scale such as iron oxide chromium oxide, nickel and copper oxides.
Table 3: spectrum processing of steel with Ni/Cu=5.0.
The SEM examination and EDS analyses of the oxide scale shown in the Figures 2 and 3, shows dimples containing inside particles of Sulphur inclusions surrounded by Cu segregation in both the cases.
This may help to explain the role of nickel in counterbalancing the harmful effect of copper, this investigation was focused to the problem of sulphide inclusions influencing the segregation of Cu and its consequence regarding the hot shortness and low ductility in steels.
Figures 2 and 3 shows that copper segregates around sulphide inclusions both in micro alloyed steels with low as well as high Ni/Cu ratio, both on the fracture surface and inside the matrix.
Cu precipitates as CuS but it also migrates to the sulphide inclusions forming segregation.
It is not clear whether it also segregates around inclusions not containing sulphur . So addition of Ni modifies the sulphide inclusion which improves mechanical properties of steel.
XRD analysis shows Oxide Scale sample of higher Ni/Cu ratio were collected in powder form for phase identification by X-ray Diffraction (XRD) method. The XRD analysis was carried out by using PANalytical X’Pert PRO X-ray in Xpert software.
Diffractometer using Co-radiation at 40 kV/30 mA setting and Fe-filter. Line focus optics were used for the analysis. The XRD pattern for the scale sample with higher as well as lower Ni/Cu ratio is presented in Figures 4 and 5. Sample shows presence of mainly iron oxides viz. Fe2O3 and Fe3O4. First layer of oxide FeO is not present in the sample.
As observed from the relative intensities of 100% intensity peaks of Fe2O3 and Fe3O4 in the samples, it can be qualitatively said that the ratio of amount of Fe2O3 to Fe3O4 is more in sample in which Ni/Cu ratio is high .
Also to ensure how the scale thickness increases with increasing in Ni to Cu ratios, scale thickness measurement was carried out by using mat lab which shows graphical representation of scale thickness and Ni to Cu ratios .
Figure 6 shows the oxide scale thickness comparison of various Ni/Cu ratios. The oxide scale formed on the sample after heating at high temperature. Scale/metal interface form on the samples is uneven. We can clearly see the difference in scale thickness. Thickness of oxide scale form on the higher Ni/Cu ratio is higher than that of all other samples having less than 2.5 Ni/Cu ratios [13-20].
• Experiment shows that the steel should contain Cu and Ni as low as possible. The Ni content should not be more than that of Cu as Ni forms uneven scale/metal interface.
• Ni/Cu ratio should be within 1 to 2.5. It should not exceed more than 2.5 as it increases the severity of cracking in surface.
As ratio increases above 2.5 it results in increasing thickness of oxide scale on the micro alloyed steel surface at high temperature.
The authors gratefully acknowledge the fully support provided for this work by KCTI, Bharat Forge Ltd. Pune. Finally, the authors would like to express special thanks and gratitude to review committee and top management of Bharat Forge Ltd for providing helpful material and comments as well as granting the permission to publish/present the research work.


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Ultra performance liquid chromatography (UPLC) is a new category of liquid chromatography that researchers are using to increase
resolution, speed, and sensitivity in a variety of applications. These benefits result from packing columns with 1.7 μm particles
and using instruments that are optimized for such columns.
Jeff Mazzeo, Ph.D.
Peptide mapping is a complex process that uses samples requiring shallow gradients with long run times. This article describes
chemical and operating considerations when adapting UPLC to peptide mapping. At optimal separation conditions, UPLC peptide
maps show more resolution than other methods and increased sensitivity. UPLC can generate particularly good peak shapes for
glycopeptides, and find good resolution for deamidated peptides. The UPLC columns show significant increases in electrospray
ionization mass spectrometry (ESI-MS) sensitivity, with only small loss of retention and peak shape when formic acid is used
in place of trifluoroacetic acid (TFA). We assert that the compelling benefits of UPLC for peptide mapping suggest that it
will become the technique of choice in the near future.
MAKING PEPTIDE MAPS
Peptide mapping is a workhorse technique in biopharmaceutical characterization.1 It is used to identify proteins based on the elution pattern of the peptide fragments, determine post-translational modifications,
confirm genetic stability, and analyze protein sequence when interfaced with mass spectrometry.
To make a peptide map, it is necessary to separate every peptide into a single peak. Therefore, peptide mapping represents
a significant chromatographic challenge, because of the complexity of peptide digests. In addition to the large number of
peptides that are generated from the enzymatic digest of a protein, there can be a large number of alternative peptide structures,
such as post-translational modifications.
There has been a long trend of reducing particle size in liquid chromatography. Modern reversed phase liquid chromatography
(LC) began in the mid-1970s with the advent of irregular 10 μm particles, and within the last five years 2.5 μm particles
have become available. The smaller particles have been used in short columns, which leads to fast analysis times but relatively
modest gains in resolving power.
Column length has decreased with particle size because the system pressure required is inversely proportional to the cube
of particle diameter. For example, reducing the particle size by a factor of two requires an increase in the operating pressure
by a factor of eight. It is, therefore, necessary to use shorter columns at lower flow rates to remain within the capabilities
of the instrument. Clearly, in order to take advantage of smaller particle sizes, both in terms of improved speed and improved
resolution, we require instrumentation capable of high-pressure operation. In addition, system band broadening must be reduced
to observe the narrow peaks generated with small particle packings.
In 2004, Schwartz and Murphy introduced the first LC system capable of operation up to 15,000 psi (1,000 bar).2 The combination of a system capable of high-pressure operation and columns packed with sub-2 μm particles has been termed
ultra performance liquid chromatography (UPLC) to differentiate it from high performance LC (HPLC).3
The benefits of UPLC vs. HPLC were originally demonstrated for small molecules (<500 Da) with reversed phase columns. Improvements
in resolving power (1.7x), sensitivity (3x) and separation speed (9x) were demonstrated for many different applications.3,4 All these benefits derive from the 1.7 μm particles used in UPLC columns. In addition to the high-pressure capabilities,
the UPLC instrument also reduces system volume and detector-cell volume to preserve the high-efficiency separations. UPLC
has gained rapid acceptance for small-molecule analytical separations, and we believe that it will displace HPLC for many
applications. The capabilities of UPLC should make higher resolution peptide mapping possible.
Table 1. LC Conditions


Foo Fighters want Tears For Fears collaboration
- Bang Showbiz
- 27 August 2017
Foo Fighters are desperate to team up with 80s band Tears for Fears on a song
Foo Fighters want to collaborate with Tears for Fears.
The 'Monkey Wrench' rockers reached out to the 80s band's singer, Roland Orzabal, to ask him to appear on a track on their new record, 'Concrete and Gold' and though he never got back to them, frontman Dave Grohl isn't ruling out hope it could happen in the future.
He said: "There was a song on the new record that I thought would be amazing if Roland Orzabel sang on or helped produce.
"I emailed him - and never heard back. It would have been a dream come true, to get together with the singer from Tears for Fears."
Tears for Fears hold a special place in Dave's heart because their music struck a chord with him when he was a young teenager.
He told MOJO magazine: "My sister had 'The Hurting' and 'Songs From the Big Chair' and I secretly fell in love with Tears for Fears.
"That melancholic sense of melody really encapsulated that specific place and time in my life - when you're 13 years old, your nuts are dropping, your voice is changing, you're breaking through puberty, so listening to Tears For Fears somehow soothes the burn.
"When 'Songs From the Big Chair' came out and they broke into the mainstream, they were inescapable in America.
I still listen to those records often."
While the band didn't secure Roland for their new LP, Boys II Men singer Shawn Stockman did lend his vocals to a track.
Dave previously said: "The guy from Boyz II Men walking through the parking lot and me saying 'would you sing on our record?' And he does - on the heaviest song on the entire record.
"It sounds like Sabbath and Pink Floyd. It's heavy. It's the last song on the record. He built a choir - it's like 40 vocals stacked. It's insane."


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Hollywood is like high school. You can never truly avoid someone and everyone remembers everything. It’s like being back in school, but as adults with more power and more money. That’s why there are plenty of actors who have grown to love working together throughout the years. On the flip side, there are plenty of actors who absolutely hate working with one another.
For those who love working together, it usually starts out the same. They meet for a movie, figure out they have a connection, and push to work together more. It’s basically like real life. For those who hate working together though, things are a little different.
If an actor continuously has to work with someone they hate, things usually end up going horribly wrong. A lot of the time, it stems from either jealous or money, although there are a few strange and out of the box incidents that can cause hatred between coworkers too.
It’s not like the real world, though. An actor can’t just forget about that one other actor they hated working with. The public wouldn’t allow that.
Instead, feuds last for years on end. Avoidance becomes key for the actors who hate working together. If an actor actually enjoys their onscreen costars, they should count themselves lucky.
Here are the 7 Actors Who Hate Working Together (And 8 Who Are Inseparable).
15 Love: Leonardo DiCaprio and Kate Winslet
Leonardo DicAprio and Kate Winslet have been two peas in a pod since their time on Titanic. While the two friends have stayed close throughout the years, they've never admitted to any sort of serious love affair.
While the world might want Jack and Rose to end up together, for now, the two compare each other more to the likes of brother and sister.
In the years after filming the 1997 hit film, DiCaprio and Winslet filmed another movie together, Revolutionary Road, in 2008.
The two friends love working together, with Winslet even admitting they regularly quote Titanic lines to each other and seek out opportunities together. The two are so close that DiCaprio even walked Winslet down the aisle at her 2012 wedding to Ned Rocknroll.
14 Hate: Jamie Dornan and Dakota Johnson
Put together for multiple movies due to their commitment to the Fifty Shades of Grey series, rumors are continuously circulating that actors Jamie Dornan and Dakota Johnson actually hate working together.
Although their characters are love interests onscreen, the two actors apparently can’t stand each other and they hate having to spend time together.
While the two actors say they are friends and speak highly of one another, sources say otherwise. Rumors of not liking each other have been circulating since the beginning.
While the two actors try their best to diminish the negative talk, they aren’t necessarily going overboard in trying to say otherwise either. It’s more like the producers behind the series is pushing to show the two as friends rather than the actors themselves.
13 Love: Simon Pegg and Nick Frost
Simon Pegg and Nick Frost have been friends since basically forever. The two have starred in films together such as Shaun of the Dead, The World’s End, and Hot Fuzz. Besides their onscreen acting work, the two have used their voices together for other films such as The Adventures of Tintin and Ice Age: Continental Drift.
Pegg and Frost have been friends since before they were famous, but fame hasn’t affected their friendship at all. While the two continue to find success, their friendship seems to prosper as they both love working (and playing) together.
In fact, not only does Pegg reguraly write roles for Frost in his films, but the two are inseparable. Pegg was even the best man at Frost’s wedding, and Frost was the best man at Pegg’s wedding. It seems like nothing will split these two up.
12 Hate: Blake Lively and Leighton Meester
Blake Lively and Leighton Meester both rose to fame thanks to the television series, Gossip Girl. They portrayed two best friends who loved each other, yet in real life, they weren’t friends at all.
While some might call their relationship “polite” and “professional,” others called it “forced” and “nonexistent.” While everyone on set seemed to get along with each other (almost), Lively and Meester didn’t mesh with each other at all.
It just goes to show that just because two people have likeable qualities doesn’t mean they will, in turn, like each other.
While a lot of the members of the cast have stayed close throughout the years, Lively and Meester have taken different paths and tend to avoid each other when they are thrown together, like at award ceremonies.
11 Love: Ben Stiller and Owen Wilson
Ben Stiller and Owen Wilson have been through a lot throughout the years. In recent years, Stiller has lost his mother and has split from his wife. Wilson on the other hand has had to fight his way back after depression hit him hard. Nevertheless, the two have always been there for each other, both on and off the silver screen.
Having started their friendship way back when, the two friends have starred in so many movies together, it’s hard to keep track of which one's the best. Their friendship is not something you can fake. They both love working with each other which is why they both continue to do so.
Wilson chalks up their golden onscreen connection to their easygoing friendship: “From when we first became friends, walking around New York, I think that we are still sort of laughing at the same things and our dynamic is still pretty similar.”
10 Hate: Sofia Bush and Chad Michael Murray
Sophia Bush and Chad Michael Murray liked each other at first sight. The two One Tree Hill stars even got married. Sadly, the two couldn’t make things work and had to divorce, only to have to work together for years after the breakup. Even though the show revolved around Murray’s character, he left the show only for Bush to take over as the star.
While Bush and Murray thought they were in love, their marriage only lasted for five months. Needless to say, a lot of love was lost between the two actors.
After Murray left the show, it seemed unlikely that the two would ever want to work together again. When asked if she keeps in touch with her former spouse, Bush had this to say: “My mother once said to me that if you don't have anything nice to say, not to say anything at all.”
9 Love: Emma Stone and Ryan Gosling
Emma Stone and Ryan Gosling were thrown together by fate, but their friendship was pure choice. Plenty of people want the two actors to be together in real life because their onscreen connection is so infectious. That being said, the two actors are just really good friends and that’s the reason why they work so well together.
Having started their friendship while on set of the 2011 movie, Crazy, Stupid, Love, the two actors have completed two more films since their original first onscreen appearance together. Stone even won an Oscar for starring opposite Gosling in La La Land.
The chemistry they have with each other makes them both better actors, hence why the movies they do together are always so great. There’s a good chance audiences will see the two of them together again in the future.
8 Hate: Julianna Margulies and Archie Panjabi
The Good Wife won many awards during its run including a 2010 Golden Globe award for Best Performance by an Actress in a Television Series – Drama, given to Julianna Margulies. As the star of the show, Margulies kind of gets to say what she wants, only to receive it.
That’s why when Margulies started having trouble with costar Archie Panjabi, Panjabi slowly made her way off the series. In fact, the two had hardly shared a scene together towards the end of Panjabi’s time on the show.
Needless to say, Margulies and Panjabi hated working together. While neither have truly talked about it, it’s basically like the white elephant in the room that everyone knows about. The two disliked each other and will most likely never work together again. It’s easy to replace a supporting role, but not as easy to replace the lead actor in a series.
7 Love: Miles Teller and Shailene Woodley
Miles Teller and Shailene Woodley first worked together as love interests on the film, The Spectacular Now, back in 2013.
Since then, the two shared the screen during the Divergent movie series. Having done multiple movies together, the two have created a solid friendship with one another. Even as both of their careers continue to prosper, they’ve kept up with each other.
Woodley once mentioned how she hopes she and Teller can be like one of those famous onscreen couples, “like Leo and Kate” for example.
Although the two played two people who hated each other in the Divergent series, Woodley still holds a place in her heart for Teller. When Woodley won the “trailblazer” award at the MTV Movie Awards, Teller was the one who presented her with it.
6 Hate: William Shatner and George Takei
The William Shatner/George Takei feud has never been a quiet one. While the two were part of the Star Trek series for quite some time, the actors didn’t necessarily enjoy working with each other.
Even now, when they should both be long over it, the feud still lives on. Needless to say, you won’t ever see these two actors work with each other again.
Takei says he invited Shatner to his recent wedding, but heard no word from Shatner. There are claims that Shtner had problems with everybody, not just with Takei.
Of course, Takei claims that Shatner likes the publicity, hence why the feud has never seemed to die down. Neither actor truly talks about it directly ever and both seem to want nothing to do with each other.
5 Love: Everyone from Sisterhood of the Travelling Pants
While The Sisterhood of the Travelling Pants filmed quite a long time ago, all four main actors (Blake Lively, America Ferrera, Alexis Bledel, and Amber Tamblyn) have all remained incredibly close. If they were offered up to do a reunion movie, there’s no doubt that they would all be on board.
Back before each individual actress found success in her own way (with the exception of Bledel who found success beforehand on Gilmore Girls), they all met to film The Sisterhood of the Travelling Pants.
While each actress has been successful, they have always made time for one another. While some of them reflect on not liking certain people they’ve worked with in the past, they are never talking about each other. The sisterhood seems to live on.
4 Hate: Sarah Jessica Parker and Kim Catrell
Although they were on Sex and the City together, along with the movies that followed afterwards, actors Sarah Jessica Parker and Kim Catrell have never enjoyed each other.
In fact, many people blame the lack of yet another Sex and the City movie on the fact that Catrell is supposedly jealous of Sarah Jessica Parker, her star status, and the amount she gets paid.
The feud between the two has been dubbed “never-ending” due to the fact that it always comes back around every few years. When Sarah Jessica Parker received a pay bump in salary on the series due to being not only the lead actress, but also an executive producer, Catrell wasn’t pleased and wanted a raise for herself too.
Everything has simply gone downhill from there. If fans want another film, they’ll have to wait because both Parker and Catrell hate working with one another.
3 Love: Jennifer Lawrence and Bradley Cooper
Jennifer Lawrence and Bradley Cooper have starred in four movies together. When they worked together on the set of Silver Linings Playbook, the two ended up together every year for three more years after that.
Their other films include Americana Hustle, Serena, and Joy. Although Cooper is much older than Lawrence, the two love working together and have become great friends.
Many rumors have circulated about Bradley Cooper and Jennifer Lawrence striking up a relationship. Unfortunately, neither seem to have interest in one another, with Cooper essentially swearing off Lawrence.
While the two love working with each other and will hopefully join forces together again soon, neither seem to have any interest in being romantic with one another. They would just rather stick to being friends.
2 Hate: Will Smith and Janet Hubert
Janet Hubert once portrayed Smith’s aunt on his hit show, The Fresh Prince of Bel-Air. However, she was later replaced after disagreements began between her and the lead star of the show, Will Smith himself. Now, years after the show ended, the feud has lasted and regardless of the past being the past, the two actors still won’t work with one another.
Hubert says what happened revolves around what every Hollywood argument seems to revolve around: money. Hubert claims Smith didn’t help her or any of his castmates with their salary negotiations.
Since Hubert has continued to talk badly of Smith since leaving the show decades ago, Smith has obviously moved on. Needless to say, he never wants to work with Hubert again and the feelings seem to be the same on Hubert’s side.
1 Love: Tina Fey and Amy Poehler
Tina Fey and Amy Poehler have been friends for years, starting way back when. The actors were close when on Saturday Night Live together and continue to do movies together semi-regularly.
They are also seen together not filming and have done well at being award show hosts in the past. Not only are they both extremely talented, but they both love working together.
Poehler and Fey seem to bring out the best in one another. Even though both found success on their own shows after they were done on SNL, neither lost contact with one another. Some of the films they have done since then include Baby Mama and Sisters.
They were also, of course, brought together again for Tina Fey’s movie, Mean Girls. Needless to say, audiences haven’t seen the end of Poeler and Fey working together.
Can you think of any other actors who hate working together or any who love each other? Let us know in the comments!


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"Why do you want to know my name?" "Because I want to know who I'm looking at..."
The first day of our 14 day Halloween Glossy Sticker countdown is of Casey Becker from Scream (1996)
Printed on high quality glossy sticker paper. The sticker is approximately 3.25 inches!


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Issues in postmenopausal hormone therapy: A 3-part CME newsletter series
Counseling patients about bioidentical hormone preparations (Part 1 of 3)
Nanette F. Santoro
Professor and Director, Division of Reproductive Endocrinology, Department of Ob/Gyn and Women’s Health, Albert Einstein College of Medicine, Bronx, New York
Deciding how to manage menopausal symptoms is a balance between the desire to provide the most effective therapy and an individual’s risks. However, patients’ perceptions of the risks and benefits of hormone therapy can add additional complexity when selecting an agent. In this 3-part, case-based CME series, James H. Liu, MD, Nanette F. Santoro, MD, and Veronica A. Ravnikar, MD, FACOG, deftly navigate challenges in patient management, offering creative solutions to common problems.
In Case 1, Nanette F. Santoro, MD, discusses approaches to counseling patients about bioidentical hormone preparations. In Case 2, Veronica A. Ravnikar, MD, FACOG, addresses the risk for venous thromboembolism associated with hormone use in postmenopausal women. In Case 3, James H. Liu, MD, discusses alternatives to hormone therapy.
ACCREDITATION STATEMENT The American Society for Reproductive Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
CREDIT DESIGNATION STATEMENT The American Society for Reproductive Medicine designates this educational activity for a maximum of 0.25 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Release Date: October 6, 2009 Expiration Date: October 6, 2010 Estimated Time to Complete Activity: 0.25 hour
It is the policy of the ASRM to ensure balance, independence, objectivity, and scientific rigor in all its educational activities. All faculty/authors participating in this activity are expected to disclose any relationships they may have with companies whose products or services may be mentioned so that participants may evaluate the objectivity of the presentations. The content and views presented in this activity are those of the faculty/authors and do not necessarily reflect those of the ASRM or Solvay Pharmaceuticals, Inc. Any discussion of off-label, experimental, or investigational use of drugs or devices will also be disclosed. The disclosure statements were reviewed by the Subcommittee for Standards of Commercial Support of the CME Committee of ASRM and any perceived conflicts of interest were resolved in accordance with the policies of the ACCME.
NEEDS ASSESSMENT Background American women on average spend one-third of their lifetimes in the postmenopausal period, characterized by diminution of ovarian function with consequent changes in metabolism and body composition. Physical and physiologic changes associated with the postmenopausal state range from annoying to life-threatening. These include hot flushes, night sweats, sleep difficulties, depression, incontinence, sexual dysfunction, osteopenia and osteoporosis, and cardiovascular disease. However, it has been difficult to distinguish changes in bodily composition and metabolism due to normal aging from those due to ovarian senescence. Problems appear to be most common during the menopausal transition, or perimenopause, although the prevalence varies with race, ethnicity, smoking, alcohol consumption, exercise, weight, and general physical condition. As the population of the United States as a whole has aged, with increasing numbers of women in the postmenopausal state, medical researchers have sought remedies for postmenopausal symptoms. For almost 50 years, physicians have recognized that administration of estrogen alleviates hot flushes in some women, although in some women administration of placebo appears also to mitigate the frequency and severity of these thermogenic vasomotor episodes.Therapy for postmenopausal symptoms has focused on either (1) treating the underlying cause, ie, diminished production of ovarian hormones, or (2) treating the symptoms, ie, difficulty sleeping, bone loss, etc. Selection of hormonal versus nonhormonal treatments must be tailored to a woman’s specific circumstances, such as presence of an intact uterus, family history of breast cancer or osteoporosis, individual history of cardiovascular problems, etc. In addition, standard medical practice requires that therapy be based on sound scientific evidence and not place women at undue risk of adverse events. The publications emanating from the Heart and Estrogen/Progestin Replacement Study (HERS) and the Women’s Health Initiative (WHI) study led to a one-third decline in the use of hormone therapy by postmenopausal women ages 50 to 74 due to apparent slight, but statistically significant, increases in certain metabolic diseases. Stratification and reanalysis of the data now suggest that in fact hormone therapy does not increase the incidence of either breast cancer or coronary heart disease. The lingering uncertainty regarding the safety of hormone therapy has driven many patients and physicians to consider nonhormonal alternatives that have not proven effective in randomized controlled trials. These include soy, isoflavones, black cohosh, vitamin E, dong quai, evening primrose oil, ginseng, licorice, and acupuncture. Some women with mild hot flushes gain relief with simple modifications of lifestyle.A substantial proportion of women have resorted to “bioidentical” hormone preparations under the mistaken notion that a bioidentical hormone is better than a US Food and Drug Administration (FDA)–tested and approved preparation. Technically, a bioidentical hormone is one that is structurally identical to a naturally occurring hormone. The term bioidentical has come to be used to refer to mixtures of naturally occurring hormones prepared individually for patients by compounding pharmacists. These preparations vary with the person preparing the mixture. In January 2008, the FDA officially warned 7 pharmacy operations that their claims about the safety and efficacy of their so-called “bioidentical hormone replacement therapy” preparations were misleading and unsupported by medical evidence because the mixtures are not tested for purity, potency, efficacy, or safety.
Identification of the Practice Gap Patients and physicians are confused by conflicting reports of the efficacy and safety of hormone therapy, both FDA-approved and non–FDA-approved bioidentical, as evidenced by the decline in women using hormone therapy despite their desire to continue therapy.
A large percentage of postmenopausal women report being worried by news reports that the 2002 WHI report showed that hormone therapy is dangerous.
Physicians report that the ambiguous and inconclusive results of the WHI reports sent mixed messages to physicians and patients that compromised physicians’ ability to discuss hormone therapy with their postmenopausal patients.
Regardless of the type of preparation used, use of hormone therapy must consider the varying formulations available, pharmacodynamics, and individual patient factors.References
TARGET AUDIENCE This activity has been designed to meet the educational needs of health professionals who care for women from adolescence to postmenopause.
ACGME Competencies Patient Care; Interpersonal and Communication Skills
EDUCATIONAL OBJECTIVES At the conclusion of the educational activity, participants should be able to: Assess the composition, purity, potency, efficacy and safety of bioidentical hormone preparations.Describe the regulatory process related to bioidentical hormone preparations.Translate reports on efficacy and safety of various hormone therapies into appropriate prescriptive decisions.Discuss the issues of concern to patients and approaches to counseling patients about bioidentical hormone preparations.
Nanette F. Santoro, MD, reports that she serves as a consultant to QuatRx Pharmaceuticals.
There may be discussion of off-label or otherwise nonapproved uses of products and/or devices.
ACKNOWLEDGEMENT This CME activity is sponsored by the American Society for Reproductive Medicine.
STATEMENT OF SUPPORT This CME activity is supported by an educational grant from Solvay Pharmaceuticals, Inc.
To obtain CME credit, you must complete the test


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We all know that the 2020 election was stolen, and Biden didn’t win those record 81 million votes!
Who would vote for him when his approval rate is 36%?
Join The True Defender Telegram Chanel Here: https://t.me/TheTrueDefender
I don’t think that he is the most likable president ever, and I think I am right!
The election was stolen in a very mean way when the observers were sent home in the middle of the night!
Trump spoke about this problem to NPR and explained how the election was stolen!
Watch the video below and hear all the details from former President Trump:


MY-B012 is a random access automatic biochemistry analyzer. It adapts 120pcs cuvette as reaction and test container and has the feature of suitable test speed, not across-pollutions and low consumable, opening reagent. It is used for testing the biochemical index of patient.
19. Software: Multinational language, use-friendly interface by Windows
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Liquid level sense system
1. The probe has the coat of TFL can reduce across-polluter evidently.
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