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The real-life "messiah" of the laborers, actor Sonu Sood is celebrating his birthday today. The actor has been receiving wishes from across the world known for his philanthropic works during the lockdown.
Because of Sonu Sood, several migrant laborers who were stuck in Mumbai and other places in the country were able to return to their homes safely during the lockdown.
The actor has been receiving wishes from his loved ones as well as fans the entire day. An artist named Vipul Mirajkar stunned the world with his skills by making the portrait of the actor on a 50,000 sq ft of land on a field. He shared the process of making the portrait on his Instagram page.
"Sonu Sood bhaiya. Birthday surprise portrait", said the caption. He dug and plowed the field to make the stunning artwork. The picture is visible with a drone flying in the air.
Shared two days back, the video has now gone viral, that photographer Viral Bhayani also shared it on his page. He said, "Absolutely unreal." Not just him internet users were also blown away by his creativity. The artist also shared a video where he met the actor and cut the cake.


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Transport Your Bikes Safely and Easily
The Elevation 4 Bike Tilt-Down Hitch Rack from Sparehand is an innovative and safe transportation vehicle rack for your bicycles. Constructed from an all steel frame with an attractive and durable powder coating, this rack holds up to four bikes and has individual cradles with Velcro securing straps. This rack will fit most mountain bikes, road bikes, and kid’s bikes. Bikes without top tube or female style frames may require frame adapter (not included). The rack fits vehicles with a 1.25-inch or 2-inch trailer hitch and the hitch bar elevates 4 inches to give you additional ground clearance. It is perfect for sedans, minivans, cross-over vehicles, as well as your normal SUV and trucks and has a total maximum weight capacity of 132 pounds. The rack has a tilt away feature that gives you access to the rear of the vehicle without having to remove the rack.

domain: design


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STATEHOUSE ROUNDUP: Health officials look to shift nursing beds after ’05 cap
Published 11/13/2012, Republic Capitol Bureau
PIERRE — The state Department of Health is considering criteria for allowing more beds at nursing homes in Rapid City, under a major change quietly passed by the Legislature last winter.Word count: 608
The full article is available to newspaper subscribers. If you are a subscriber please log in to continue reading.

domain: medical


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Online Availability: No Longer Available
Order Online Pick up In-Store for free
This item ships FREE to any of our Cabela's Canada locations for pick-up. Learn More
Northland Colorado Blades Spinner Lure
The Baitfish-Image® Colorado Blades are stamped from solid brass, and feature “holographic” Baitfish-Image® designs for maximum flash and life-like reflection! They “match-the-hatch” and produce the illusion of live bait. Per 3.
Blade size: #4.

domain: hobby


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Maria Rybakova was born in Moscow. She studied Greek and Latin in Russia, then in Germany, and subsequently in the USA. She is currently based in Kazakhstan. Her first novel, Anna Grom and Her Ghost, was published in 1999. Several novels and short stories followed. Maria Rybakova is a recipient of numerous literary awards in Russia, including Students’ Booker Prize, Eureka Prize, Serguei Dovlatov Prize, Antologia Award, The Russian Prize, Globus Award. Her novels have been translated into German, Spanish and French. Her book-length poem Gnedich appeared in 2015 from Glagoslav, in a translation by Elena Dimov.
Highsmith Was a Troll: On Richard Bradford’s “Devils, Lusts and Strange Desires”
Maria Rybakova plumbs the depths of “Devils, Lusts and Strange Desires. The Life of Patricia Highsmith” by Richard Bradford....
A PEN Petition in Defense of Alexei Navalny
We, the members of PEN-Club Moscow and the Free Word Association, in according with the principles formulated in the Charter of ...
Perseverance of Love: On Irvin Yalom’s “Becoming Myself”
Maria Rybakova reviews psychiatrist Irvin Yalom's recent memoir, "Becoming Myself."...
Let Us Rejoice While We Are Young
Maria Rybakova reviews Mircea Eliade's early novel "Gaudeamus," recently translated by Christopher Bartholomew and released by Istros Books....
Against the Devil: The Tormented Life of Czesław Miłosz
Maria Rybakova reflects on the tormented life of Czesław Miłosz, as told in a new biography by Andrzej Franaszek....
BLARB BLOG POSTS
You Are Not Who You Think You Are: On Katherine Verdery’s My Life As A Spy: Investigations in a Secret Police File
The Madness of Anna Schmidt: A Russian Prophet In Search of Her Beloved

domain: literature


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Moving to Budapest in November as with a pre-existing health condition that requires regular visits to a doctor, I'm a bit worried about the healthcare in Hungary. Coming from the UK where I don't have to pay a fortune for treatment, will I have access to public healthcare in Budapest? Really need to make sure I'm going to be able to stay healthy and also not break the bank trying...
Expat Health Insurance
If you’re thinking about taking out private health insurance, our trusted partner Cigna Global is very aware of all the difficulties that expats can face when it comes to healthcare in a new location, so they have created a range of international health insurance plans specifically designed for expats, which you can tailor exactly to the needs and ensure access to quality care for you and your family.
Sirelo has a network of more than 500 international removal companies that can move your furniture and possessions to your new home. By filling in a form, you’ll get up to 5 quotes from recommended movers. This service is free of charge and will help you select an international moving company that suits your needs and budget.
Healthcare in Hungary is generally of a high standard. If you're working in Hungary under a local employment contract you should have access to free or subsidised medical care through the Health Insurance Fund. You should also be able to get access to public healthcare with your European Health Insurance Card, which is valid within all EU member states.
You can read more about this and what you need to quality for access to free public healthcare in our Healthcare in Hungary page.
All the best with your relocation!
The healthcare system is actually really good in Hungary. Just sort out your insurance. There also a good selection of private doctors available in Hungary.
And good luck!


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Bress Wine, Cider and Produce is a multi-award-winning winery, with luxury accommodation, weekend restaurant and art gallery space.
Bress is nestled in Harcourt Valley with spectacular views of the granite outcrops of Mount Alexander and the surrounding foothills. The winery has been granted sustainable practices status, and offers a mix of products, including wine, cider, mineral water, accommodation, weekend restaurant and events across the year.
From Spring to Autumn, lunch at the weekend ‘Bresstaurant’. You can enjoy the view of Mount Alexander in their alfresco dining area outside Cellar Door or soak up the atmosphere of the engine room of Bress at one of the tables in the Winery.
Artist spaces have been established throughout the sustainable gardens and on the walls of the Bress working winery. Visitors are treated to fresh exhibitions as new artists are featured every six to eight weeks. Come explore the magnificent surroundings and appreciate the local talent unique to the region.
Staying at the Bress Homestead allows visitors to truly immerse themselves in the ‘Bress Life’. Their five-bedroom homestead is available for your next luxurious country escape.
Bress Wine, Cider and Produce is a recipient of Gourmet Traveller Wine Best Cellar Door Awards 2013-2018.
Alfresco/Outdoor Dining Bar Between $20 and $30 Carpark Fully licensed, No BYO Lunch Over $30 Share Plates Suitable for Functions Woodfired Cooking

domain: travel


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Violence In Jerusalem Demands A New Approach
With arab violence raging on the Temple Mount and increased attacks on Jewish worshipers walking through the Old City of Jerusalem to the Kotel, repeating failed solutions year after year feels like a dead end. The answer to today’s security challenges in Jerusalem does not lie in the security forces, which are trained to only deal with problems as they arise. Rather the real solution is something very different and long term.
Jerusalem’s Ramadan violence requires a long term strategic shift in order to permanently stamp it out.
Ateret Cohanim in partnership with the city has been able to use the neutrality of real estate purchases and Jewish renewal projects throughout the Old City and surrounding neighborhoods to spur urban development and organic changes in day to day security by implementing the sovereignty Jerusalem already legally has.
Ideological real estate investments have both a neighborhood impact as well as a long term structural change in Jerusalem’s demographic conundrum. Beyond that, where Jews return to learn and to raise families draws in security forces to not only protect the Jewish residents, but those arabs seeking peace and good neighborly relations.
Year after year, Ramadan comes and violence ensues, yet only by purchasing, developing, and ultimately enforcing the city’s sovereignty throughout the entirety of Jerusalem will radical Islamic violence subside and peace be restored.

domain: sociology


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Pharmachem Laboratories Inc. has pledged $1 million to Vitamin Angels, an organization dedicated to eliminating nutrient deficiencies in children, according to Howard Schiffer, founder and president of Vitamin Angels. The long-term commitment by Pharmachem will result in donations of $200,000 per year over the next five years to the Vitamin Angels organization.
“Through long-term commitments like Pharmachem’s, we’ll be able to double the number of children reached this year to 20 million,” said Schiffer. “Vitamin Angels has been around for 16 years, and last year was the first time we were able to reach over 10 million malnourished children worldwide in one year.”
“Since 2003, Pharmachem has donated approximately $2.5 million dollars to our cause making the company one of our largest contributors,” added Schiffer. “They have supported us not only with monetary contributions, but with raw materials, as well.”
David Holmes, Founder and President of Pharmachem Laboratories, said “Vitamin Angels is making a huge difference in the lives of children around the globe who are at risk for serious medical conditions, and we’re proud to be a partner in this crucial mission.”
Vitamin Angels is the largest public/private partnership in the world solely focused on reaching malnourished children with vitamin interventions. The mission of Vitamin Angels is to reduce child mortality worldwide by connecting infants and children under five with essential nutrients, especially vitamin A. One of its programs is Operation 20/20, which provides children in 30 countries with vitamin A capsules to reduce mortality and prevent blindness caused by a deficiency of this vitamin. Another program, Thrive to Five, provides multivitamins to malnourished children under 5 years old, as well as pregnant and lactating women, in at least 20 countries, including the U.S.
Current estimates list the number of chronically malnourished children around the world at 150 million. In 2009, Vitamin Angels reached 11,057,289 children (and mothers) in 40 countries, including the US. In 2010, Vitamin Angels’ goal is to reach 20 million children with essential nutrients in over 40 countries, including the US. The organization is poised to double the number of beneficiaries it reaches in 2011 to 40 million.
According to Schiffer, “Our motto is that we reach the unreachable—those children, primarily in rural areas, that are not being reached by the public healthcare system. We’re getting the word out to other organizations who may be able to help us with financial commitments similar to Pharmachem’s, so that we can reach our goal of helping more and more of these underserved children.”
Pharmachem Laboratories, Kearny, NJ, develops, supplies and manufactures a variety of high-quality, efficacious nutritional ingredients under the strictest quality control. For more information, call 1-800-526-0609 or visit http://www.pharmachemlabs.com/
Vitamin Angels is dedicated to reducing child mortality worldwide by advancing availability, access and use of essential micronutrients, especially Vitamin A, to newborns, infants and children under five. In 2010, Vitamin Angels will connect over 20,000,000 million children in 40 countries, including the U.S., with the vital nutrients they need as a foundation for good health. 1994. To learn more about global malnutrition, micronutrient deficiencies, and Vitamin Angels’ solution for change, visit http://www.vitaminangels.org/


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Home Tags CASSELBERRY, Fla.
Tag: CASSELBERRY, Fla.
Podiatric Surgeon Specializing In Pediatrics Comes To Lake Mary, Casselberry
LAKE MARY and CASSELBERRY, Fla., Dec. 6, 2022 (SEND2PRESS NEWSWIRE) -- It's difficult for any parent to watch their child get sidelined by foot and ankle pain. Worse yet-finding a podiatrist who specializes in pediatric cases. But for those who live in Lake Mary and Casselberry, accessing a qualified provider is no longer an issue. Fellowship-trained podiatric surgeon Shruti Dosi, DPM, recently joined Modern Foot & Ankle, a Central Florida podiatric group, bringing her exceptional skills in pediatrics and reconstructive surgery to the Orlando area.

domain: news


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12. Rainbow nails
A rainbow is a symbol of love, peace, and freedom. Many women believe rainbow nails are for teens and girls in their 20s only.
However, you can try out this cute nail art idea even in your 50s. When it comes to nails, your age doesn’t matter at all. Actually, when it comes to anything.
I hate beauty rules and don’t respect those who say what we must do and avoid at a certain age. A professional beauty expert can advise but doesn’t dictate to you. So if you wanna try a rainbow manicure, just do it!

domain: artistic


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Covid 19 made a lot of changes in the world and one of the saddest for our group was having to postpone our yearly quilt show not once, not twice, but thrice! We were all thrilled to finally be able to enjoy getting together for quilt viewing, shopping with vendors, fundraising and quilting camaraderie.
The 2022 Metro Quilt Expo displays showcased 208 quilts from bed sized to table runners and everything in between.
It was a beautiful show! Lots of talent and variety of designs.Bobbie S
More than 1,200 quilt enthusiasts attended the two day show at the Hilton Garden Suites in Fargo. Many who attended were tremendously enthusiastic about both the show and its new location. We were pleased to host 12 vendors offering the latest in quilting fabric, tools, and machines in the ballroom and lobby. Much shopping opportunity was to be had.
It sounds like we’re having the best kind of party in the ballroom!Kim S
In addition to the quilt show, two of our signature fundraising projects were very successful. The yearly silent quilt auction raised $1,240 which will be used to fund our outreach projects for the year.
In addition to our silent auction, we instituted a new fundraising project. Members of the Fargo Moorhead Quilters donate themed baskets of supplies that appeal to quilters. Some baskets were put together with new quilters in mind. Others were intended to encourage quilters to explore new techniques. The basket which garnered the most tickets was themed for ironing & pressing! All together the 19 baskets raised $2,746 which help in launching new projects this year.
Thank you for the time and effort you put in on the Quilt Expo. It was a wonderful show.Janet V
A show the size and complexity of the Metro Quilt Expo is not an easy undertaking. The three days it took for intake, judging, and hanging the show required 382.5 hours of volunteer time. During the two days the show was open, an additional 245.5 hours were invested by volunteers. And behind the scenes, more that 523 hours went into planning and preparations in the year leading up to the show. That means the 120 members of Fargo Moorhead Quilters spend nearly 1,100 hours putting together this year’s excellent show.n
“This was a great show! So happy to get to see all this beauty in one room (and the shopping was fun too). Thank you Fargo Moorhead Quilters!”


- Hindi news
- Former Navy Chief Said – Deployment Will Be Done To Deal With Maritime Threats From China Pakistan
New Delhi4 hours ago
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This picture is from March 5. The Navy had successfully tested the BrahMos missile in the Arabian Sea under the Atmanirbhar Nirbhar Bharat programme.
After the Army and the Airforce, the Indian Navy will now deploy BrahMos missiles in strategically important maritime areas. Retired Navy Chief Vice Admiral Satish N Ghormade told news agency ANI on Saturday that Bramhos will be deployed in areas where there is the highest threat from China and Pakistan.
Explain that on March 30, the Ministry of Defense had signed an agreement of Rs 1700 crore with BrahMos Aerospace Private Limited. Under this, it was decided to deploy Next Generation Maritime Mobile Coastal Battery (NGMMCB-LR) and BrahMos missiles near the sea coasts. Their delivery to Navy will start by 2027.
Ghormade said that the Cabinet Committee on Security headed by Prime Minister Narendra Modi has recently approved the proposal of 17 warships. These include two important proposals including six next-gen missile vessels and 11 next-gen offshore patrolling vessels (OPVs). This is a big decision to enhance the capability of the Indian Navy.
These are pictures of BrahMos missile batteries. There are many missiles in it. Only the new version of BrahMos missiles will be deployed in the sea areas.
Ghormade said that the deal for Next Generation Patrolling Ships would enhance the Navy’s surveillance capability in an important region like the Indian Ocean. This will help us in tracking and monitoring mission based deployment. We will get 11 OPVs by 2026. Their construction has been given to Goa Shipyard and some other companies.
With the arrival of these ships in the Navy, the combat capability of the Navy will be further strengthened. Apart from this, operations like anti-piracy, counter-infiltration, anti-poaching, anti-trafficking, non-combatant evacuation operations, search and rescue will be beneficial.
BrahMos will neutralize the threats of China-Pak
Satish N Ghormade said that the threat of China and Pakistan in the maritime areas will now be monitored by BrahMos missiles. All of them will be equipped with the updated technology of BrahMos. This will neutralize any threat coming from enemy countries. He said that the special feature of the new version of BrahMos is that it can target land and air apart from the sea.
How did BrahMos get its name?
BrahMos has been developed under a joint agreement between India’s Defense Research and Development Organization (DRDO) and Russia’s Federal State Unitary Enterprise NPOM. BrahMos is a medium range stealth ramjet supersonic cruise missile. This missile can be launched from a ship, submarine, aircraft or land.
It has also been claimed in some reports that this missile has been named after two rivers, the Brahmaputra of India and the Muskva River of Russia. It is believed to be the fastest anti-ship cruise missile in the world.
This year the indigenous BrahMos missile took part in the Republic Day parade.
BrahMos at a glance
- BrahMos is a supersonic cruise missile, which can be launched from submarine, ship, aircraft or land.
- BrahMos is based on Russia’s P-800 Oceanic cruise missile technology. This missile has been handed over to all the three wings of the Indian Army, Army, Navy and Airforce.
- Several versions of the BrahMos missile exist. Land-launched, ship-launched, submarine-launched air-launched versions of BrahMos have been tested.
- BrahMos can destroy its target at a speed of Mach 2 speed (2500 km / h) at a range of 290 km when fired from land or sea.
- The BrahMos missile can be launched from a submarine from a depth of 40-50 meters from inside the water. The submarine-launched BrahMos missile was tested in 2013.
How dangerous are BrahMos missiles
- India has the advanced supersonic BrahMos cruise missile built in collaboration with Russia. It is capable of hitting its target 400 kilometers away. Apart from this, India is also working on a hypersonic cruise missile BrahMos-2 which can be ready by 2024. Its capacity can be up to one thousand kilometers.
- There are also four types of BrahMos missiles. These include surface-to-surface, air-to-surface, sea-to-surface and under-sea missiles.
- BrahMos is among the fastest missiles in the world. It flies at a very high speed at a low height from the ground, due to which it is not easy to catch it with the anti-missile system. This is the reason that this missile is capable of carrying nuclear weapons for a long distance in a short time.
- Pakistan has subsonic missiles named Babur and Raad which are capable of hitting surface to surface.
Also read this special news of Bhaskar related to Brahmos…
1. Successful test of BrahMos missile: Target targeted in Bay of Bengal
Indian Airforce successfully test fired BrahMos air launched missile in the Bay of Bengal. It can target targets up to 400 km away. The Air Force said in its official statement – This missile has been tested from Sukhoi Su-30 fighter aircraft. Read full news…
2. Two months ago, the Air Force had successfully tested the missile.
The Indian Airforce successfully test-fired the BrahMos air-launched missile in the Bay of Bengal on 29 December. It can target targets up to 400 km away. The Air Force said in its official statement – This missile has been tested from Sukhoi Su-30 fighter aircraft. The Defense Department said that during the test, the missile hit the target ship in the middle. It is the anti-ship version of the air-launched version of the missile. Read the full news here…
3. Case of BrahMos missile falling in Pakistan: 3 Air Force officers sacked; These include Group Captain, Wing Commander and Squadron Leader.
On March 9, a BrahMos missile of India (there was no war head on it) fell in Mian Channu city of Pakistan. Expressing regret on this missile fired by mistake, India had assured the investigation. Now three officers of the Indian Air Force have been dismissed in this matter. An Indian Air Force (IAF) official said that the officers who have been dismissed from service include a group captain, a wing commander and a squadron leader. Read the full news here…


Despite the flood of people arriving here for the first time every day, Houston has never been a tourist town. Ask anybody: the skiing sucks, the mosquitos are packing heat and the traffic is stressful enough to put one off the very concept of travel for life. As an added bonus, the weather is too u ... More >>
Politics is an ugly business, but things went from ugly to violent this week when supporters of state Rep. Hubert Vo, Democrat, and those backing Republican opponent Al Hoang showed up at an early voting center in District 149 on Monday afternoon. Hoang's party took offense to a banner that Vo's su ... More >>
Connect the dots and you’ll find our city’s restaurant scene has been dominated by a few hardworking culinary pioneers and their descendants.
Plans to reroute Buffalo Bayou will rescue an unstable waterway. Or they will destroy one of the last natural stretches of riparian forest on the bayou. Consensus seems to have taken a hike.
The Colbert Report Get More: Colbert Report Full Episodes,Political Humor & Satire Blog,Video Archive There are a lot of misconceptions when it comes to life in Houston. We're fat. It's hot. Our scenery is ugly. We all wear cowboy hats every day and have oil wells in our back yards. Well, we do all ... More >>
Six historical paintings at Houston's federal courthouse have raised some hackles with two federal judges, who believe the paintings dredge up offensive imagery of slavery. The paintings, depicting the Houston Ship Channel in the late 1870s, were completed between 1938 and 1941, and were displayed ... More >>
Now THAT is some serious flood water.When Tropical Storm Allison hit in 2001 and dropped almost three feet of rain on central Houston, there were all sorts of terms like the "100-year storm" or the "500-year storm" thrown around. These kinds of weather events do more than just destroy propert ... More >>
A Facebook page for the victims
If you missed last night's debate then you missed a good one. In fact, it was the best one to date. Check the live-blog coverage to catch up on the juicy details.Gene Locke's background and possible conflicts of interests were brought up midway through the debate via a question submitted by a viewer ... More >>
As we noted yesterday, most Houstonians have no idea who they want for their next mayor. A poll shows more than two-thirds don't favor any of the candidates, partly as a result of financially crimped campaigns that haven't been able to advertise much yet.Houstonians who were called for the poll a ... More >>
From McG's Terminator, that is. What a drag.
I just can't get enough of Houston's East End/Second Ward/Ship Channel area, so that is where the latest installment of the Sole of Houston took us. I don't think I can recreate the route with anything more than about 90 percent accuracy, but my best guess is that it looked something like this.David ... More >>
Photo by Beau BThis week's cover story (coming online later today) is about the drive to bring legal casino gambling to Galveston. With the Island's economy in shambles after the one-two punches of Hurricane Ike and the global financial meltdown, a vocal contingent of Galvestonians think the best wa ... More >>
From West U to deep space
Its true belivers trash Hair Balls
The Pearland school board — entertainment for years to come!
A reporter, a photographer and canoeist Tom Helm paddle from the Galleria to Galveston Bay by canoe and kayak, finding beauty, danger and urban debris in equal measure
Critics say Perry's turnpike plans will take a terrible toll on Texans
An MFAH show and a crop of new galleries are redefining what Latino art is supposed to look like
Here's how Metro wants to sell us on light rail
Critics wonder if massive TDCJ cuts will be a prelude to privatization
Zumm Escudier has put the Angelika Cafe back on track, but her path has been long and winding
Candidates clash in a castaway district, exes attack, and Bell wringers rumble for a final round with Brown. Voters, pick your fight.
Latinos find little sympathy from Commissioners Court
Ex-congressman Stockman is labeled a co-conspirator in prescription fraud
Houston's latest image-boosting campaign gets a big hand from the Chron
In the '70s, Jim Harithas's radical chic collided with the CAM. Twenty-five years later, he's back, gunning his engines at the Art Car Museum.
After a career serving kingmakers, can Jim Edmonds really be his own leader?
Houston's first female hockey team gives new meaning to the term "body check"
When political egos and a basketball star vow to beautify a derelict building next door to Enron Field, what do you get after more than a year? Nothing.
Will past financial flops come back to haunt a front-runner?
Exercising rights in Seabrook can land you in court
Has the fight over port expansion turned a bay watchdog group into a rubber duck?
More for Les and the Rest. Brown finally figures out that spending equals power
The city of Houston is being carved into special taxing districts, promising windfalls for some, financial burdens for others
Government and civic boosters know the way to clean up the air in polluted southeast communities: add another chemical plant
Pasadena police wanted bad trucks off the road. Then big-rig politics wrecked their plans.
As Jew Don Boney has moved upward in public life, have his values changed to meet his needs rather than those of his constituents?
Roland Garcia has the political backing to be the U.S. Attorney for South Texas. He also has a brother imprisoned for murder and drug trafficking -- a fact he somehow forgot to tell his congressional sponsors. That may not be enough to disqualify him, but
In 1966, Cleveland "Big Cat" Williams fought Muhammad Ali for the world heavyweight championship. In 1996, he fights just to get by.
Privatization of Houston's municipal golf courses has been a bad deal for everybody but the operators. But golfers and taxpayers had best look out: the city's on the verge of giving away two more of it courses.
Can Buffalo Bayou beshaped into an economic redevelopment tool?
The city's sports tycoons maneuver for inside position, and the questions mount: Who needs it? Why? At what cost?


Anyway, feel free to check out the newly revealed opening cinematic and a slightly ripe trailer for the upcoming PlayStation Vita and Nintendo 3DS game. It's currently slated for a November 7 launch in Japan. An international release has yet to be announced.
Felynes can dress up as Dante, Blanka, and Chun-Li in Monster Hunter 4 Ultimate
3:00 PM on 12.15.2014


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Liphar (pronounced Lifer) Magazine is proud to announce the launch of its first issue. A new and exciting on-line magazine with a theme dedicated to Literature, Photography and Art.
Key elements will include sourcing articles about literature, photography and art as promotion on Social Media and blogs for writing tools, publishing, photography tips, art and current trends. There will also be regular columnists, thought provoking articles, informative interviews and general information.
While Liphar Magazine covers literature, photography, art subjects and trends, the features in each issue also span a variety of fields that appeal to those who enjoy these genres and want something more from the experience other than reading about the technicalities.
This edition will include by author Taylor Fulks, an article about her latest book. And in her own words..."My novel is very dark, disturbing and GRAPHIC. It is a controversial book about Child Sexual Abuse."
Interviews with Erotica author Karena Marie and nature photographer Murray Coleman will also be featured.


Plans to build a huge Zipwire in the Lake District have been rejected.
The owners of Honister Slate Mine wanted to build a 1035m long zip wire but the Lake District National Park Authority Development Committee turned down the plans at a meeting in Kendal, by seven to four votes against it.
The revised plans were for a shorter zip wire than the mile long structure that was turned down in September 2011.
More top news
Emma Jesson brings you Saturday night's forecast
The Pirelli Rally began with a ceremonial start at the tyre manufacturer's Carlisle factory.
Torrential rain in the run up to today's crucial play off game between Salford City and Workington Reds.


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Emerging Tribal Identity
Over the years in India, sociologists, anthropologists, and the non-tribal masses have, deliberately or inadvertently, developed an image of a 'tribal' as that of a sub-human being, fully deprived of the attributes of a civilized life. One such tribe is the Mina tribal society of India's Eastern Rajasthan. The Minas lived in isolation for a long period of history. When India's Criminal Tribe Act was dropped, the Minas began to come closer to the regional caste culture. The constitutional safeguards and securities guaranteed to the Minas have brought about certain social and cultural changes among them. This has also changed the image of the Minas in particular and the other tribal groups in general. This new image has created concerns about their social and cultural identity. The Minas have now made their entry into government services. They have also attained some of the characteristics of modernity. This present work studies the developments among the Mina tribal society of Eastern Rajasthan. The book will be of special interest to researchers, policy makers, and bureaucrats concerned with tribal development.
Publication Date: 12/31/2008

domain: library


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|Year : 2020 | Volume
| Issue : 2 | Page : 49-55
Dengue virus infections and anti-dengue virus activities of Andrographis paniculata
Mohamed Ali-Seyed1, Kavitha Vijayaraghavan2
1 Department of Clinical Biochemistry, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia, Tabuk 71491, Saudi Arabia
2 Department of Chemical Engineering, Agni College of Technology, Chennai, Tamil Nadu, India
|Date of Submission||19-May-2019|
|Date of Decision||13-Dec-2019|
|Date of Acceptance||31-Dec-2019|
|Date of Web Publication||14-Jan-2020|
Department of Clinical Biochemistry, Faculty of Medicine, University of Tabuk, Tabuk, Tabuk 71491
Source of Support: None, Conflict of Interest: None
Dengue is a debilitating disease that poses a perpetual threat to human health and increases the global economic burden every year. Despite advances in medical sciences, dengue virus (DENV) infects approximately 200 million people every year. To date, no effective antiviral is valiable to treat DENV in individuals despite great efforts in accomplishing these goals. Numerous approaches have been used in the search for dengue antiviral like screening of combinatorial compounds against DENV enzymes and structure-based computational discovery. In recent years, investigators have turned their focus into medicinal plants, trying to identify compounds that can be used as dengue antiviral. Nature represents a great reservoir of potential substances that can be explored with the aim of discovering new drugs that can be either used directly as pharmaceuticals or can provide drug leads, which can be scrutinized further for the development of new anti-dengue natural product. Many previous investigations have dealt with numerous plant extracts or bioactive principles for their antiviral property as they normally considered being safer when compared to synthetic drugs. Andrographis paniculata belongs to family Acanthaceae and is generally known as ‘king of bitters’. Diverse bioactive compounds from this plant such as diterpenes, flavonoids, xanthones, noriridoides and other miscellaneous compounds have exhibited their potential as therapeutics for various chronic as well as infectious diseases. This review is based on literature review on scientific journals, books and electronic sources, which highlights the pathogenesis of DENV and describe an assortment of bioactive principles that have been possessing antiviral potential, which include dengue and discuss the therapeutic efficacy and mechanism of action of Andrographis paniculata. However, a detailed and more comprehensive clinical trial on mammalian tissues and organs is needed in future studies.
Keywords: Andrographis paniculata; Dengue; Phytochemicals; Natural products; Andrographolide
|How to cite this article:|
Ali-Seyed M, Vijayaraghavan K. Dengue virus infections and anti-dengue virus activities of Andrographis paniculata. Asian Pac J Trop Med 2020;13:49-55
|How to cite this URL:|
Ali-Seyed M, Vijayaraghavan K. Dengue virus infections and anti-dengue virus activities of Andrographis paniculata. Asian Pac J Trop Med [serial online] 2020 [cited 2023 Mar 31];13:49-55. Available from: https://www.apjtm.org/text.asp?2020/13/2/49/275412
| 1. Introduction|| |
The emergence of microbial infectious diseases constantly threatens the humankind. Viruses, with few base pairs of genetic material have the ability to enter inside the cell and nuclear level of the human cells owning a few million base pairs of the genome and can influence them at the molecular level and responsible for host cell lysis. Viral outbreaks in endemic areas trigger panic among the world population because of the upsetting surge in infection spread due to the reduced traveling speed and many other multifactorial facts exploiting the host defenselessness. Previous investigations have well demonstrated that infectious disease transmission patterns always continued to change because of various human activities including travel mostly by humans’ contribution to changing patterns of risks. Other than the above, it is important to identify other factors, which may contribute to disease spread among species, and viral duplication mechanisms in new variants at basic science level to precisely evaluate the risk of a newly identified viral strain spread to the human subjects.
In the last two decades, investigators have shown tremendous interests towards virus causing unexpected illness and epidemics among humans, wildlife and livestock and their changing patterns of infectious diseases. These outbreaks often have seriously stretched both local and national resources at a time when healthcare spending in the economically developed world has been constrained. On the other hand, methods to control the viral spread is inadequate or undeveloped and remain poor in some regions where many of these diseases have their origin, e.g. Ebola outbreak in a few African countries including Democratic Republic of Gongo.
Despite the progress made in immunization and drug development, many viruses lack preventive vaccines and efficient antiviral therapies, which resulted in the generation of viral escape mutants. Therefore, identification of new potential antiviral drugs is crucial. In this regard, plants and phytochemicals are an excellent source for such discoveries. In recent years, medicinal plants were chosen as imminent origin for the development of new drugs to treat various diseases caused by viruses. Phytochemicals provide a rare practice for the discovery of antiviral drugs with significant pharmacological outcomes. Till date, limited numbers of anti-viral drugs are available for effective treatment, yet many of them pose viral resistance and produce side effects when the drug is consumed for longer period of time.
Herbals used by traditional medicine practitioners for various human ailments play a vital role and their need continues to increase in the coming years. According to World Health Organization’s (WHO) recent estimation, approximately 2 500 medicinal plant species are available globally to treat an innumerable number of ailments and diseases. Native plants spread throughout tropical Asian countries including India, China, Indonesia, Malaysia, and Sri Lanka, as they are a rich depository of medicinal plants. Having close life existence with the nature and herbal plants, a vast majority of world-wide population still depend on these herbs and learn to utilize them for their immediate health care needs. These remedial plants yield a wide variety of secondary natural products (nearly around 100 000) and are classified based on their structural compositions and their synthesis pathways.
Natural product research is always viable to explore, extract and establish their therapeutic properties. With the advent of many new as well as improved advance, technologies including genetically engineering approaches help to elucidate the complexity of plant- derived natural products in terms of structural and functional features. Currently, 25% of herbal-derived prescribed drugs are being used, and among those, many are anticancer and anti-infective in nature. In recent years, these findings place herbal plants in greater position, for they are the source of bioactive compounds which will be utilized for the development of new drugs against various viruses. In fact, phytochemicals provide a unique and innovative way to find various new antiviral drugs with substantial outcomes. However, these new natural products and their possible drug leads with well-deciphered mechanisms of action are important for the development of medicine to avoid any existing therapeutic difficulties.
Andrographis (A.) paniculata (Burm.f.) Nees is a common medicinal plant [Table 1], which is predominantly found as isolated patches in most of the tropical Asian countries,,,, . Numerous beneficial effects of A. paniculata described in various reports, are involved in the treatment of hypertension, cardioprotective, anti-cancer, anti-inflammatory and antioxidant action. It also used to treat gastrointestinal tract, upper respiratory and herpes infections, sore throat, hepatitis and a variety of other chronic metabolic diseases like obesity, diabetes.
|Table 1: Source and antiviral potentials of important chemical constituents of Andrographis paniculata.|
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Many potential bioactives from A. paniculata have been reported, including flavonoids, glycosides, lactones and diterpenes. Among these compounds, flavonoids were prominent in most parts of plants including leaves. The following two flavonoids such as 5, 7, 2’,3’- tetramethoxyflavanone and 5-hydroxy-7,2’,3’- trimethoxyflavone were principal ones. Gorter et al.  were the first to isolate a bitter colorless bioactive principle known as andrographolide from A. paniculata. The chemical name of andrographolide is 3α, 14, 15, 18-tetrahydroxy-5 β , 9 β H, 10 α -labda-8, 12-dien-16-oic acid γ -lactone.
In recent years, many studies have investigated substantial anti-viral potentials of A. paniculata,. These studies have identified various anti-viral bioactive compounds such as polyphenols, alkaloids and flavonoids, saponins, quinones, terpenes, proanthocyanidins, lignins, tannins, polysaccharides, steroids, thiosulfonates and coumarinsfor nearly 23 viral induced ailments. These compounds have inhibited viral entry into host cells by various mechanisms. These reports highlighted the therapeutic efficacy and action mechanism of A. paniculata against various viral infections including dengue. Hence the present review discusses the antiviral potency of A. paniculata derived natural products and their roles in inhibiting the viral replication with special focus on dengue virus and proposes A. paniculata derived bioactive agents as an important antiviral herbal medicine.
| 2. Dengue virus (DENV)|| |
2.1. Description of DENV
DENV, a positive single strand RNA containing enveloped virus, belongs to flaviviridae family and genus of Flavivirus. The DENV virion typically presents as 40-50 nm spherical particle with a genomic core containing single-strand positive-sense RNA (@11kb in length) covered by a glycoprotein envelope. Dengue is a fast and widespread mosquito-borne viral disease, typically, by mosquitoes (Aedes aegypti and Aedes albopictus) and the viral infection has been reported as the second commonest cause for hospitalization of tropical travelers in Europe next to malaria.
DENV has the following structures such as capsid, membrane, and envelope as well as seven non-structural proteins which are identified as NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5. Simmonds et al.  have briefly explained the details of the current International Centre for Taxonomy of Viruses (ICTV 2017) classification of DENV and the viral proteins replication. Normally, the viral replication occurs in the hosts cytoplasm with the involvement of both viral and host cellular proteases cleavage. The viral protein is formed initially as a polyprotein after the translation of viral genomic RNA.
The replication process follows a complicated topology by placing the different proteins at a different level around the endoplasmic reticulum (ER). During the replication and assembly, the proteins of capsid (C), NS3 and NS5 remain in cytoplasm, the NS1, membrane and envelope proteins move towards the tubules of the ER; whereas NS2A and B, NS4A and B stay inside the plasma membrane of the ER. The various spatial presentation effectively guides the successful assembly of the virus by strongly influencing the host. The virions are transported as cytoplasmic vesicles and exported via exocytosis.
According to WHO, four different kinds of dengue viruses are listed: they are DENV1-4. Among those, DENV-2 serotype is the most prevalent and continues to be a threat to society. All four serotypes were reported to be emerging from the sylvatic strains from Southeast Asian forests. The environmental condition in tropical countries like Southeast Asian region is an important factor in the increased prevalence and incidence of outbreaks. The emergence of new fifth type threatens the future. DENV-2 is one of the highly virulent serotypes.
2.2. Classical dengue fever and its outbreak
DENV infects 200 million people per year and disables 3.6 billion people approximately. The recounted threat to the public never declines in spite of advances in medical therapeutic science. The endemic area for DENV has stretched over 128 countries. DENV-2 appearance was noticed in many countries like Malaysia, Indonesia, and Thailand in 1960, and ten years later (1970) in China, Srilanka, India, and Singapore. Philippines and Thailand reported the first cases of DENV-3 and DENV-4; and thereafter, it is reported every year in the Asian countries including Thailand, Malaysia, Indonesia, China, Cambodia and Singapore. It is noteworthy. DENV is known as arbovirus in Southeast Asian countries. The co-circulation of all the DENV types in endemic areas were increasingly reported even though the reports were inconsistent due to restricted supply of specific diagnostic aids.
Currently, co-infections with different serotypes of DENV has become an alarming threat in hyper-endemic countries including Southeast Asia, India, and China. The virus infects the host cell by adsorption mechanism by binding to receptors and penetrating plasma membrane to uncoat the viral genetic material. Integrated episomic genetic element then interferes various processes including transcription, replication, translation, assembly respectively and followed by the release of material upon host cell lysis.
Although there are four distinct types of verified dengue serotypes imposing enormous research works to achieve the control, but emergences of new fifth type threaten the future. However, currently, DENV-2 is one of the highly virulent and predominant serotypes compared to all the other four-dengue types. Clinical signs of DENV infection consist of apparent/mild feverish presentation, as well as other symptoms like skin rash, myalgias, headache, vomiting, nausea and joint pains and deadly hemorrhagic condition. Additionally, severe dengue cases may have hemorrhagic dengue shock syndrome (DHF/DSS).
DENV largely targets and causes maximum damages to blood vessels mainly on the vascular endothelial cells and its supporting structures. The crucial issues of severe DENV infection are due to the dysregulated immune response leading to extensive bleeding resulting with platelet reduction and hypovolemia, which was not responding to the fluid and platelet replacement rather worsening the situation. Treatment outcomes with corticosteroids to modulate the immune system were inconclusive and not widely accepted. Intravenous immunoglobulin intervention suggested for a clinical trial with limited evidences. A tetravalent vaccine against all the serotypes of DENV is still under elaboration and need worldwide approval for its clinical use. In line with this, a recent study by Biswas et al.  have demonstrated that the early results of an ongoing phase 3 randomized trial of a tetravalent dengue vaccine candidate (TAK-003) in regions of Asia and Latin America in which the disease is endemic have shown promise achieving an overall vaccine efficacy of 80.9% (95% CI, 75.2% to 85.3%; 78 cases per 13 380 (0.5 per 100 person-years) in the safety.
2.3. DENV pathophysiology
Despite the urgency regarding the control and treatment of DENV infections, the pathogenesis remains insubstantial. Currently there are no effective antiviral therapeutic as well as vaccines available or under clinical trials to halt or eliminate the viral spread. DENV infected host does develop lifetime immunity but it is restricted to the particular serotype. Consecutive DENV infection with another serotype might end with the worst situation due to original antigenic sin, which was due to the cross-reaction of the antibodies developed for the first infection binding ineffectively with the antigens of new infections and leaving them uninhibited.
The four antigenicallydistinct dengue types and very closely related predominant serotypes make hurdle for the development of successful vaccine, because each serovar is distinct which may not protect the infection of other three serovar. Thus vaccine produced from one serotype may not be effective and would increase the risks and invite more severe illnesses. This was evident with Dengvaxia, the only approved tetravalent vaccine against DENV-2, which is less protected from other serotypes.
Emerging clinical reports alarm the troubles of post-infection complications and co-infections, and co-morbidities accumulating the fatalities. There are many fatal infections leading to postinfection complications including DENV and lack of enough renewal cells during repairment due to the extensive involvement. Furthermore, other fatal complications such as dengue hemorrhagic fever and dengue shock syndrome are also enumerated. Currently suggested DENV treatment options are immunomodulatory and immunosuppressive medicines, however, these suggested drugs do possess strong contraindication during viral infections.
2.4. Dengue fever control measures
In recent years, dengue is a fast emerging pandemic viral disease worldwide and its incidence is alarmingly increasing both urban and semi-urban residential areas. There is an alarming 30-fold increase of dengue cases which results not only financial burden but leads to huge health care fund allocation every year. The affected country and regional public health administration face huge challenges to curb dengue disease and find out some effective control methods. In general, there are three solutions to prevent and control dengue disease and its epidemic: (a) to inhibit the action of DENV inside the human body by inducing specific immunization by the administration of the vaccine (b) by eliminating the infectious chains by vector control and (c) by epidemiological surveillance at the early stages in both probable affected and new areas.
Although mosquito control measures are paramount protective practice, yet, successful implementation and control measures maintaining face many practical difficulties. Since all these approaches have their own independent merits, suggesting their implementation is highly required to find their effectiveness. Until now, there is no accepted treatment with synthetic or natural medicines, however, they are widely accepted because of cost-effective for prophylaxis and further treatments. Thus, there remains a clear need for novel treatment strategies aiming at developing safe anti-dengue drugs for future treatment.
However, on the positive note, the continued search for new natural compounds with appropriate validation process is required to reveal new structure-activity relationships. These approaches help to develop many new drug leads like glycyrrhetinic acid for human papilloma virus (HBV), acetoxime as an inhibitor of herpes simplex virus (HSV-1) and caffeic acid as an influenza NA antagonist. The finding of drug leads like punicalagin and chebulagic acid has the capacity of blocking the entry of many viruses because of their GAG-competing ability, which could aid to develop multi-spectrum antivirals for the control and prevention of many viruses.
| 3. Beneficial attributes of A. paniculata|| |
3.1. Antiviral potentials of A. paniculata
In recent years, many investigations have reported substantial anti-viral potentials of A. paniculata besides its spectrum of other pharmacological activities. However, most of these studies have reported A. paniculata’s antiviral potential only against few selected viruses like influenza A, HIV antigen-positive H9 cells,, herpes simplex type 1, flaviviruses, pestiviruses and DENV-1. Besides the above, A. paniculata reduced viral virulence and protected from the life-threatening ability of human papilloma virus type 16 (HPV16) by suppressing its transcriptional activity and reduction of E6 oncoprotein expression in the host. Moreover, A. paniculata’s potential bioactive compound, andrographolide effectively inhibited the expression of various Epstein-Barr viral lytic proteins such as Rta, Zta, and EA-D in P3HR1 cells. To support further, Uttekar et al.  demonstrated that this compound and its by-products inhibited the gp120-mediated cell fusion of HL2/3 cells with TZM-bl cells signifying that andrographolide might be ideal candidates for better prevention and treatment of HIV infection.
3.2. Anti-platelet activity
It is well established that in DENV infected patients, platelets are one of the most vulnerable cell population by direct and/or indirect mechanisms of infection; however, the exact mechanism triggering platelet reduction is yet to be elucidatedin detail. It is common to observe both thrombocytopenia and platelet dysfunction in dengue, both strongly related to the clinical outcome. Thus, platelets are frequently affected in dengue, either for alteration of their own functionality, for “silent transport” of virus, or as an anti-viral immune cell.
Phytoconstituents extracted from A. paniculata have exhibited various anti-platelet activities by modulating platelet activating factor through various signaling pathways like eNOS-NO/cyclic- GMP PLC γ 2-PKC and PI3 kinase/Akt-MAPKs. One of the active phytocompounds of A. paniculata diterpenoid, especifically 14-deoxy-11,12-didehydroandrographolide exhibits dose and time-dependent inhibitory action on thrombin-induced platelet aggregation, whereas, neoandrographolide exhibits none. The observed results suggest that the other new compounds like two flavanoids such as andropaniculosin A and ropaniculoside A present in the extracts may be responsible and attributed for high anti- platelet activity. To support further, a study by Amroyan et al. has shown that andrographolide inhibits PAF-induced human blood platelet aggregation in a dose-dependent manner. However, study results suggest that the mechanism of action of andrographolide is entirely different from a known NSAIDs action. The andrograpahlide actions are most probably related to cardiovascular and antithrombotic activity described elsewhere for A. paniculata
3.3. Anti-dengue activity
Methanol extracts of A. paniculata exhibit anti-dengue activity on DENV-1. The study has shown that the extracts have the ability to inhibit the viral activity of DENV-1. It is very interesting to note that the treatment of Nilavembu Kudineer and Adathodai Manapagu combination to twenty DENV affected patients for the scheduled period of 7 d showed substantial symptomatic relief and improvement in the management of dengue fever. It is very important to note that the crude extract of A. paniculata has shown anti-larval activity for many insects including mosquito species like Culex quinquefasciatus, and Aedes aegypti. The following main phytochemical compound bicyclic diterpenoid lactone and some constituents of diterpenoids like andrographolide, neoandrographolide (NAND), 14-deoxy andrographolide (DAND), and 14-deoxy-11, 12-didehydroandro-grapholide (DDAND) have been identified and they are responsible for larvicidal, anti-microbial and anti-inflammatory activities. Since andrographolides are not soluble in water, they have some limitations and cannot be directly used as a healing agent.
Many in vitro and in vivo investigations are conducted with plant-derived bioactive principles against dengue viruses,,. In this regard, various flavonoid compounds from ethanol/methanol derived extract of A. paniculata have been described that they are possessing antiviral properties including dengue with 75% of inhibition. The antiviral activity might be due to the presence of the following natural compounds such as terpenes, polyphenols, and flavonoid of ethanol extracts. Although flavonoid compounds are the main constituent of interest in search of an anti-dengue agent, the other potential compounds like diterpenes which include andrographolide, 14-deoxy andrographolide, and 14-deoxy-11, 12- didehydroandrographolide should not be neglected in future clinical trials to decipher their anti-dengue mechanism of action as these two compounds have exhibited their anti-HIV activity in various investigations.
In summary, based on the available evidence, the exact antiviral mechanisms of action of andrographolide and other bioactive compounds are yet to be explored in detail. However, existing data suggest host cell proteins such as actin and NF- κ B are the direct targets of andrographolide and may thus exert its effect through these proteins as proposed. In addition, andrographolide modulates many molecular and cellular mechanisms including oxidative stress, autophagy, mitochondrial function and the unfolded protein response pathway. Thus, the compound andrographolide and other derivatives from A. paniculata exert their action on multiple pathways within the cell causing various antiviral effects. To explore further, the anti-DENV efficacy, especially the detailed mechanism of action of neoandrographolide, dehydroandrographolide and other derivatives of andrographolide, namely, 14-deoxy-11,12- didehydroandrographolide, 14-deoxy andrographolide and their synthetic counterparts such as dehydroandrographolide succinic acid monoester (DAMS), 14-á-lipoyl andrographolide (AL-1), 14-acetyl- 3,9-isopropyl-ideneandrographolide, 14-acetylandrographolide, 3, 14, 19-triacetylandrographolide, and 3,9-isopropyl- ideneandrographolide need to be investigated by employing multiple advanced technical approaches.
DENV, one of the tribulations of the world, has no specific treatment with antivirals and the clinical trials with the tetravalent vaccines have been reported with limited results. With the available encouraging reports, this review highlights and recommends A. paniculata as an antiviral therapy for DENV infection, which could potentially open a novel scientific area to embark its antiviral potentials. Yet, some limitations still exist like post-infection challenges, which need to be rigorously subjected to various pre- clinical and clinical trials by investigating at the different period of its lifetime to verify the permanent damages induced by DENV. A.paniculata potency assays need to be standardized and experimented to predict the therapeutic efficient dosage as mentioned in earlier studies.
Conflicts of interest statement
The authors declare no conflict of interest.
M.A.S conceived the review idea and focus, drafting the article, critical revision of the article. KV involved in the references collection, involved in drafting the article. Both M.A.S and K.V have contributed to the final manuscript revision.
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Amroyan E, Gabrielian E, Panossian A, Wikman G, Wagner H. Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. Phytomedicine
Sheeja K, Kuttan G. Modulation of natural killer cell activity, antibody- dependent cellular cytotoxicity, and antibody-dependent complement- mediated cytotoxicity by andrographolide in normal and Ehrlich ascites carcinoma-bearing mice. Integr Cancer Ther
Sheeja K, Kuttan G. Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo
by Andrographis paniculata
extract and andrographolide. Immunopharmacol Immunotoxicol
Govindarajan M. Evaluation of Andrographis paniculata
Burm.f. (Family: Acanthaceae) extracts against Culex quinquefasciatus
(Say.) and Aedes aegypti
(Linn.) (Diptera: Culicidae). Asian Pac J Trop Med
Wang J, Tan XF, Nguyen VS, Yang P, Zhou J, Gao M, et al. A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasis. Mol Cell Proteom
Xiao XW, Fu HZ, Luo YH, Wei XY. Potential anti-angiogenic sulfates of andrographolide. J Asian Nat Prod Res
Kaul TN, Middleton E Jr, Ogra PL. Antiviral effect of flavonoids on human viruses. J Med Virol
Kumar RA, Sridevi K, Kumar NV, Nanduri S, Rajagopal S. Anticancer and immunostimulatory compounds from Andrographis paniculata. J Ethnopharmacol
Panraksa P, Ramphan S, Khongwichit S, Smith DR. Activity of andrographolide against dengue virus. Antiviral Res
Yu CY, Lu TS, Wang CW, Tsai KL, Liu YP, Cheng YP, et al. Induction of heme oxygenase 1 and inhibition of tumor necrosis factor alpha-induced intercellular adhesion molecule expression by andrographolide in EA. hy926 cells. J Agric Food Chem
Lu H, Zhang XY, Wang YQ, Zheng XL, Yin Z, Xing WM, et al. Andrographolide sodium bisulfate-induced apoptosis and autophagy in human proximal tubular endothelial cells is a ROS-mediated pathway. Environ Toxicol Pharmacol
Xing WM, Yuan TJ, Xu JD, Gu LL, Liang P, Lu H. Proteomic identification of mitochondrial targets involved in andrographolide sodium bisulfite-induced nephrotoxicity in a rat model. Environ Toxicol Pharmacol
Gu LL, Zhang XY, Xing WM, Xu JD, Lu H. Andrographolide-induced apoptosis in human renal tubular epithelial cells: Roles of endoplasmic reticulum stress and inflammatory response. Environ Toxicol Pharmacol
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domain: biology


text:
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Take a Refreshing Plunge into the Bible
Journey inside the pages of Scripture and you'll meet a personal God who enters individual lives and begins a creative work from the inside out. Immersion Bible Studies is your guide for that journey. Shaped with the individual in mind, Immersion encourages simultaneous engagement both with the Word of God and with the God of the Word to become a new creation in Christ.
Immersion, inspired by a fresh translation, the Common English Bible, stands firmly on Scripture and helps you explore the emotional, spiritual, and intellectual needs of your personal faith. More importantly, you'll be able to discover God's revelation to you through readings and reflections.
So, take the plunge and find the transforming love and knowledge of a personal God.
Revelation features 8 sessions . Leader Guide Included.
|Format: DRM Protected ePub|
Vendor: Abingdon Press
Publication Date: 2011
Availability: In Stock
Series: Immersion Bible Studies
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text:
1969 St John St, Regina (Centre) Saskatchewan, Canada
1 150 $
Regina Centre 2 chambres à coucher Appartement à louer
Saint John House is located on Saint John Street, just at the intersection of Victoria Ave & St John Street East of downtown Regina.The house is located close to the popular Victoria Ave in the Core...
Distance approximative du point de centre de recherche (Regina, Saskatchewan): Moins d'un kilomètre
40 Froom Crescent, Regina (Est) Saskatchewan, Canada
Regina Est une chambre à coucher Appartement à louer
Froom Apartments are located in the East Regina community of Glenelm Park. The apartments are situated blocks away from the Ring Road to the East and Victoria Avenue to the North.Froom Apartments are...
Distance approximative du point de centre de recherche (Regina, Saskatchewan): 2,9 kilomètres

domain: geography


UMIDIGI Bison Pro First Leaked: 48MP Triple Camera & Temperature Sensor
UMIDIGI is working on a new rugged phone, UMIDIGI BISON Pro, which is a new member of its BISON series. The newly leaked reader of BISON Pro shows it has a 48MP triple rear camera, an infrared thermometer sensor and a similar design to the BISON series. UMIDIGI is globally giving away 10 units of the new BISON Pro and its upcoming TWS Earbuds UMIDIGI AirBuds Pro with ANC feature.
UMIDIGI BISON series has been very popular since its release because this series provides users with high-end specifications at a low-end price. After the success of BISON and BISON GT, now the company is working on a new member of the BISON series called BISON Pro. The design of this device is almost the same as BISON, but its color is different. According to its slogan, BISON Pro seems to be equipped with a stronger processor, which will be a breakthrough in the BISON series. As a rugged phone, BISON Pro not only has a solid structure and IP68 & IP69K, it also comes with a 48MP triple rear camera, which is very suitable for outdoor and sports lovers.
There’s been a lot of talk about the upcoming UMIDIGI BISON Pro sporting the same quad rear camera as BISON, but a new photo posted on the company’s official Twitter clearly shows a triple rear camera with an infrared thermometer. Since the outbreak of the epidemic, UMIDIGI has been trying to equip each product with this infrared temperature sensor, doing its best to give users more sense of security. In addition, the leak confirms that BISON Pro has the same design as BISON which is rugged yet lightweight and thin, and it is also expected to feature IP68 & IP69K rating resistance and high-quality drop-proof and dustproof. Furthermore, BISON Pro has a waterdrop display that is similar to BISON.
For now, little is known about the full specs information of BISON Pro, but we can expect more on it. UMIDIGI said that BISON Pro is a leap in speed, so the processor of BISON Pro will be a big breakthrough from previous products. And BISON Pro comes with all-new color options, one is black and the other is gray, but it’s unknown if there are more colors to choose from. What’s more, if UMIDIGI goes in a similar route with the BISON and BISON GT, expect the big battery, liquid cooling system and X-xais linear moter to stay.
Lastly, UMIDIGI is giving away 10 units of UMIDIGI BISON Pro and its upcoming UMIDIGI AirBuds Pro, a True Wireless Stereo earphone with ANC feature. If you are interested in UMIDIGI BISON Pro and the other new products, you can go to UMIDIGI’s official website to get more information and join in the giveaway.


In the Hollywood movie version of the SNC-Lavalin affair, the part of Clerk of the Privy Council Michael Wernick will be played by a man dressed as a traffic cop. Standing in front of what looks to all the world like a 10-car pileup, his character will repeat the following catchphrase: “Move along people, nothing to see here.”
In his appearance last week at the Commons justice committee, Mr. Wernick said the machinery of government was working as intended, traffic was flowing normally and there was absolutely no car crash to be seen. It was just journalists and opposition politicians rubbernecking at a lot of nothing.
He insisted that nobody had sought to unduly or inappropriately influence then-justice minister and attorney-general Jody Wilson-Raybould, in an attempt to get her to intervene in the criminal prosecution of SNC-Lavalin.
Ms. Wilson-Raybould’s recollection of what happened at the intersection of Justice and SNC-Lavalin could not be more different.
On Wednesday afternoon in Ottawa, the former attorney-general described “a consistent and sustained effort by many people within the government to seek to interfere in the exercise of prosecutorial discretion in my role as the attorney general of Canada in an inappropriate effort to secure a deferred prosecution agreement with SNC-Lavalin.”
She said the pressure to intervene in the criminal case came from 11 different people. She said it was conveyed via approximately 10 phone calls and 10 meetings, some directly with her and some with her senior advisers. She said the pressure came from the very top – the two most senior officials in the Prime Minister’s Office, the Clerk, and Prime Minister Justin Trudeau himself.
It is hard to exaggerate the seriousness of this. Her allegations go to the foundations of the Canadian justice system’s independence, and they rise to the highest levels of the government. They are all the more powerful because this accusation against the Trudeau government is being made by one of its most senior members.
Until Wednesday, Ms. Wilson-Raybould had said almost nothing since her removal as justice minister and attorney-general, citing limitations placed on her by solicitor-client privilege and by cabinet confidentiality.
She had not said what was behind her unprecedented public letter, issued in January after she was shuffled out of the Justice ministry, in which she felt the need to express the view that “our system of justice must be free from even the perception of political interference,” thereby hinting that during her time in office this had been an issue of more than just theoretical interest. Nor had she explained why, after the Prime Minister said that her continued presence in cabinet as Veterans Affairs minister proved nothing was amiss, she immediately resigned from cabinet.
As a result, although The Globe and Mail had reported on Feb. 7 that Ms. Wilson-Raybould had been put under pressure to intervene in the case of SNC-Lavalin, it was until now unknown precisely who she felt had put pressure on her, or when, where and how this pressure was applied.
As of Wednesday afternoon, Canadians know rather a lot more. Ms. Wilson-Raybould laid it out, chapter and verse.
She said that she and her senior staff were repeatedly contacted by other senior officials, urging her to reach a deferred prosecution agreement with SNC-Lavalin. The law offers the option of crafting such an agreement in corporate criminal cases but, in this instance, the prosecutor and the Director of Public Prosecutions had declined to offer the company such a deal, and Ms. Wilson-Raybould decided against overruling them.
She also believed – correctly – that an attorney-general must not be subject to political pressure from her own government to intervene in matters before the courts. Yet what she described on Wednesday was a sustained, four-month-long campaign to influence her, first to intervene and then, once she had decided not to intervene, to get her to change her mind.
It is impossible to overstate the seriousness of these allegations. All of the people she has named, including the PM’s former principal secretary Gerald Butts, his chief of staff Katie Telford and the Prime Minister himself, must give a full and complete answer. There is no avoiding it.
Canadians can neither move along nor look away. Nor can the government. What has been alleged is just too big.
Wilson-Raybould alleges ‘consistent and sustained’ effort by Trudeau, officials to ‘politically interfere’ in SNC-Lavalin case
Read Jody Wilson-Raybould’s opening statement on SNC-Lavalin affair


text:
One dead, 7 injured in Scottsville Road crash
One person is dead and seven others were injured following a crash Thursday afternoon on Scottsville Road in Chili.
Monroe County Sheriff's Lt. Samuel Bell said witnesses told police a northbound Mercury Sable crossed over the center line shortly after 2:30 p.m. and collided head-on with a bus carrying people with the Arc of Monroe County.
The bus overturned as a result of the crash, and the driver and five passengers were transported to Strong Memorial Hospital with minor injuries, Bell said.
The driver of the Sable, Scott Walker, 48, of Rochester, was pronounced dead at the scene and his passenger, Shamarr Rouse, 27, was transported to Strong with a head injury.
According to the Monroe County Sheriff's Office, the Sable "was seen swerving, crossing over both the fog line and the center line just prior to colliding with the bus."
According to a release from Strong, the victims range in age from 27 to 57 years old and "are under evaluation in the emergency department."
According to its website, "The Arc supports more than 1,700 people with developmental or intellectual disabilities as they strive to reach their full potential."
Barbara Wale, CEO of the Arc of Monroe County said in a statement, "The van’s driver, who had been trained in Arc safety protocols, and five passengers, all individuals served by the Arc, were on board. All were transported to Strong Hospital, where they are being treated for minor injuries.
"We appreciate the fast response of local sheriff’s deputies and emergency medical personnel on-scene."
Wale said the Arc is deferring questions about the accident to the Monroe County Sheriff's Office.
The investigation is ongoing.


The Toshiba PDR-T30 ($499 direct) is Toshiba's third-generation digital camera that now offers a larger built-in touchscreen, higher resolution, and more features than its plastic predecessors. Although it has some quirksimage is at best mediocreand the unit does not ship with image-editing software, the PDR-T30's combination of style and simplicity will appeal to hardcore gadgeteers who want to have fun with their photos. The camera is also a potentially valuable tool for builders, contractors, and others who can use the PDR-T30's ability to mark up images on the touchscreen.
The medium-size, rectangular PDR-T30 has a rounded all-metal body with a sliding chrome shutter to protect the 2X zoom lens when the power is off. The pop-up flash is always available, since it opens when the lens is exposed. On the rear of the camera is a 0.9- by 1.7-inch touchscreen; inside this is a 1.5-inch, 118,000-pixel LCD viewfinder. The only two physical controls on the back of the camera are a tiny joystick-like Control/Zoom button and a Mode button underneath. The camera is designed to stand on end as well as on its bottom, but where there would normally be a tripod screw socket, there is a port for the charger/AC adapter. The camera is powered by a lithium-ion battery, connects to the PC via USB, and images save to an SD/MMC card.
The PDR-T30's 3.3-megapixel CCD yields a maximum resolution of 2,048 by 1,536 pixels, with two compression levels. It's strictly a point-and-shoot camera with no manual controls. You can select ISO (100, 200, 400), flash (auto, off, fill, red-eye), white balance (auto and five presets), and shooting modes (macro, portrait, night, black-and-white, sepia, sports, and multishots). It can record 320-by-240 video, but there's no audio capability or video-out port.
Operating the PDR-T30 is a mixed bag. Because you must activate both the sliding shutter and a separate power switch on top of the camera to begin, boot-up takes over 10 seconds. With the flash activated, recycling time is a poky 10 seconds. The flash illuminates a scant 7 at ISO 100, and the zoom is slow and noisy. The joystick button is frustratingly imprecise, and the touchscreen is quite sensitive and can be changed inadvertently merely by brushing it accidentally. Because there's no optical viewfinder and the touchscreen is always on, battery life is limited to only 1 hour 27 minutes, or 167 shots.
On the other hand, the touchscreen is sharp, bright, intuitive, and responsiveand great fun. Although the icons are nonstandard, once you learn them, working the touchscreen is a piece of cake. Toshiba provides a ministylus attached to the camera strap, and although the documentation warns against using fingers or excessive force on the touchscreen, it works quite well using just a fingernail or a pen point. The menus, playback, and slide show make use of visually-exciting wipes and cutaways, and the pan-and-zoom capability is one of the best and fastest we've seen. There's no customization on the slide show, however. You can choose whether to use physical or virtual navigation, since the joystick duplicates the same commands as the touch screen.
Activating the paint program on the PDR-T30 brings up a 15-color palette, three brush sizes, and pen, bucket, and erase icons. Drawing is fairly easy, but although you can enlarge and pan to view your work, you can't draw on zoomed images. You can save only a VGA-size copy, not a full-resolution completed image.
Image quality is disappointing. Our simulated daylight default test shot was underexposed, with a significant cyan cast and unappealing colors. Our default flash shot was well illuminated but muddy, with a yellow cast. The Toshiba PDR-T30 is a bit pricey for a 3.3-megapixel digital camera that lacks audio capability and imaging software. But if a touchscreen that you can draw on and make notes on is a killer app for you, this is the best product of its type on the market.


text:
On Wednesday, the Middle School Boys' Basketball team went on the road to play the Riverfront Christian Rams on their home court. After tip-off there was no looking back. The young Yellow Jackets jumped off to an 18-0 lead in the first quarter and a 23-0 half time score. Everyone for R-MA was able to play in every quarter. Eight of the ten players scored during the game and the first team only played nine minutes. The second unit gained valuable playing experience and played well as a group. The Yellow Jackets distributed the scoring among eight of the ten participating players. Leading the way for the Jackets was eighth-grader Stanley Richards with 12 points. Seventh-grader Michael Sumner, eighth-graders Gil Iphael and Jacob Karen each scored 8 points, seventh-grader Jonathan Bunker threw in 5 points, eighth-grader Shawn Levitt added 4 points, and eighth-grader Griffin Loper contributed 2 points.
With this win the Jackets are 6-0 overall and 2-0 in the VMSC. On Thursday the Jackets have a home game against the Front Royal Flames. Thanks to the parents, siblings, grandparents, faculty and staff, and fans for supporting the R-MA hoopsters this year


Game Of Thrones new season is just around the corner and Maisie Williams appeared on Jimmy Fallon last night to promote it.
Any of us would kill for a little spoiler as we get excited for season 8 and that's just what Maisie gave us.
Have a look at the clip here:
Of course, this was a April Fools stunt but credit to her acting here.
Even though I knew what was going on, I still felt awkward watching it.


Wi-SKY Says "Black Box" Searches May Become Obsolete
Real-time wireless monitoring of
CDR data is available for the first time, according to Wi-SKY
Inflight, which introduced the technology Monday. The company says
its exclusive 100 megabit-per-second wireless data transfer makes
the early detection and cockpit coaching for aircraft performance
problems possible while still in flight.
The complete aircraft avionics data stored on the Flight Data
Recorder is too voluminous to display on the cockpit instrument
panel, and too large to transmit to the ground with current
The FDR monitors 88 parameters of aircraft performance from as
many as 1,100 sensors and can accumulate as much as four gigabytes
of data per flight. Current cellular or satellite technology can
only transmit between 1 and 3 Mbps, which makes a real-time
download of the total aircraft avionics data impossible during
flight and excessively slow after the flight. Therefore pilots must
now rely upon extracted highlights of the Black Box
"At today's data rates, it would take up to six hours to
transmit four gigabytes of data from each one-hour flight,"
explains Michael Leabman, CTO of Wi-SKY Inflight. "In contrast,
Wi-SKY can transmit an entire four gigabyte file in less than 13
minutes. A real-time transfer rate of at least nine Mbps is
necessary to download a file this large during flight."
The Wi-SKY air-to-ground data link can transmit 100 Mbps to each
aircraft, which is more data than a satellite transmits to an
entire continent - 80 Mbps to share among hundreds of customers.
"Our 100 Mbps system is like giving each plane a dedicated
satellite to deliver its data," notes Leabman.
After an aircraft accident, when the complete avionics
information in the Black Box is examined, the cause of some crashes
is determined to be aircraft conditions unknown to the pilots
during the last stages of the flight.
"It's unfortunate that airlines have had to wait to recover the
Black Box after a crash to find out everything that the aircraft
avionics data files were reporting about flight performance but now
Wi-SKY's technology will change all of that," explained Grant
Sharp, CEO of Wi-SKY Inflight. "By monitoring and analyzing the
complete FDR data files during the flight, we can discover
performance issues and enable ground-based expert engineers and
pilots to coach the cockpit crew during an emergency."
Wi-SKY Inflight has developed an air-to-ground connection with
airborne aircraft that will deliver 100 megabits of data per second
(Mbps) -- fifty times faster than today's technology. Wi-SKY
Inflight's technology makes them the first to offer real-time
continuous data transfer of the complete avionics data file. Once
the total flight data package is transmitted real-time to
ground-based mainframe computers, analysis can be performed that
was never before possible.
"Continuous live monitoring of fuel tank sensors, reading
hydraulic system sensors at every critical point throughout the
aircraft, measuring aircraft stress factors, tracking multiple
airspeed indicators, monitoring complete engine trend and other key
data will enable pilots to validate their instrument readings,"
Sharp emphasizes. "When problems are detected, ground based
personnel at the airline operations monitoring center can be
immediately summoned to help the pilots deal with an emergency
situation. This can help avoid cockpit confusion that is the
leading cause of commercial aviation deaths."
Wi-SKY's intent is to offer dozens of additional real-time
flight performance reports and analysis that will streamline
airline operations and generate significant cost savings.
Sharp says some airlines have been more interested than others,
and the adoption process can be a long one. "(T)hose that have
validated our technology with their due diligence process have
cumbersome decision-making processes. We are optimistic that our
real-time, total-data avionics monitoring will be on three or four
major airlines by the end of next year."
Wi-SKY Inflight is engaged in deploying ground stations
throughout North America and Europe to support the first phases of
their air-to-ground network. Base stations are needed every 200
miles, which is about 125 to 150 stations in both North America and


Introduction: When it comes to finding the perfect ac that combines efficient cooling, energy savings, and advanced features, the LG AC 1.5 Ton 3 Star emerges as a top contender. This AC unit from LG was created to provide superior performance while keeping energy consumption in check. Let’s delve in to the exceptional features and advantages of the LG AC 1.5 Ton 3 Star and understand why it stands out as a dependable and smart selection for your cooling needs.
Powerful Cooling Capacity: The LG AC 1.5 Ton 3 Star features a robust cooling capacity, rendering it suitable for cooling medium to large-sized rooms. Having its efficient cooling mechanism, this AC unit ensures quick and uniform cooling, developing a comfortable environment even during the hottest summer days.
Energy Efficiency and Savings: In today’s energy-conscious world, the LG AC 1.5 Ton 3 Star sets a brand new standard for energy efficiency. Having its 3-star rating, it optimizes energy consumption without compromising on cooling performance. This means significant energy savings, helping you reduce your electricity bills while minimizing your environmental impact.
Advanced Cooling Technologies: Equipped with advanced cooling technologies, the LG AC 1.5 Ton 3 Star ensures optimal comfort and convenience. It comes with a powerful compressor that rapidly cools the room, providing instant relief from the heat. The AC’s efficient airflow design ensures even distribution of cool air through the space, eliminating hot spots and delivering a constant cooling experience.
Intelligent and Convenient Features: The LG AC 1.5 Ton 3 Star comes filled with intelligent features that enhance user experience and convenience. It gives a range of modes, including auto-restart, sleep mode, and timer functions, allowing you to customize and program the AC’s operation to suit your preferences. Additionally, the AC can be controlled remotely via the LG ThinQ app, providing seamless connectivity and control from anywhere.
Improved Indoor Air Quality: Having its multi-stage filtering, the LG AC 1.5 Ton 3 Star takes care of not merely cooling but also improving indoor air quality. lg ac 1.5 ton 3 star filtering efficiently removes dust, allergens, and bacteria from the air, ensuring a solution and healthier living environment for you personally and your family.
Durability and Reliability: Buying a durable and long-lasting ac is essential, and the LG AC 1.5 Ton 3 Star excels in this aspect. Built with high-quality components and backed by LG’s reputation for reliability, this AC unit was created to withstand years useful, providing you with with reassurance and minimizing maintenance requirements.
Conclusion: The LG AC 1.5 Ton 3 Star impresses using its powerful cooling capacity, energy efficiency, advanced features, and durability. It ensures a cushty indoor environment while helping you save on energy bills. With intelligent functions and improved air quality, this AC unit is a smart selection for anyone seeking optimal cooling performance. Select the LG AC 1.5 Ton 3 Star and experience the perfect mixture of efficiency, convenience, and comfort for your cooling needs.


text:
Montenegro Citizenship by Investment: An Overview Citizenship by Investment programs are designed to attract high-net-worth individuals to a country. Montenegro is no exception, offering an Investment program that grants applicants permanent residency and citizenship eligibility. After meeting certain conditions, the investor can qualify for Montenegrin citizenship after five years of residence.
The Montenegro citizenship by Investment program provides several benefits to foreign investor. First, the applicant is granted permanent residency status in Montenegro. This includes the ability to live, work, and study in the country. Furthermore, Montenegrin citizens enjoy visa-free travel to over 120 countries, including the European Union.
Furthermore, the Montenegro citizenship by Investment program provides several financial benefits. These include the ability to make large Investment with the potential to generate substantial returns, tax incentives, and access to Montenegro’s banking sector.

domain: law