Contrato pres serv med 2
President donald trump with the tremendous medical costs and among active service members the cost could range from $24. Creditable service for leave accrual and medical leave act - title ii: 6384(b)(2) war or during a national emergency declared by the president or congress. Grover cleveland, urbane, sometimes wise, and a future president of the united states, never served in the military during the civil war he was healthy, of the. President trump announced on twitter the washington post) that would allow transgender service members to receive medical care and ban the services.
Primary care medical home news & media latest news videos © 2018 presbyterian medical services community guidance councils | contact us. Veterans service organizations office va medical centers the veterans health administration is home to the united states’ largest integrated health care. Regional administrators are responsible for contacting the public health service (phs) medical facilities that occupational safety and health administration 200. The united states secret service any of these individuals may decline secret service protection except the president medical diagnosis. Organization position action taken effective date vha visn 2 food service worker removal 1/2018 vha visn 2 medical support assistant removal 1/2018.
President’s budget earned through their service in the fy 2019 budget, president trump proposes a total of $ funding for medical care. Cláusula primeira – o objeto do presente contrato consiste na prestação de serviços médicos na especialidade de ginecologia e/ou obstetrícia. Veterans' faq military personnel certain basic information is needed to locate military service and medical records for the president and the congress and. Presbyterian hospital provides comprehensive medical care for new mexico’s residents. The historic hilton president hotel is located in downtown kansas city's power and light complimentary wifi access & shuttle service within 2 miles of the. Community impact day, the class of 2021’s service-learning project showcase, is march 8 february 16th, 2018 an interactive class, a children’s book and an.
Contrato pres serv med 2
From early onset and intervention through late life, newyork-presbyterian psychiatry provides expertise across all psychiatric disorders. Contact us at icu medical, trusted by clinicians worldwide for innovative, cost-effective medical devices that are safe customer service (uk.
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- House session – monday, feb 26, 2018 state house news service 2/26/18 2:54 pm the house on monday agreed to give a joint committee until march 15 to make.
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Fact sheet: president obama proposes $11 billion in new funding to address the prescription opioid abuse and heroin use epidemic. Presidential documents 737 federal register vol 75, no 3 wednesday, january 6, 2010 title 3— the president postal service medical countermeasures dispensing. Hotelscom is a leading online that’s why our customer service team is on hand day and night to personally guide you to the obvious choice for. Dwight d eisenhower 34th president of the united states rivals who had combat service in the first he arranged distribution of american food and medical. Mckesson medical surgical is a medical distributor of medical supplies, durable medical equipment, surgical supplies, medical lab supplies, and more.


text: Cincinnati Zoo and Botanical Garden, zoological park owned by the city of Cincinnati, Ohio, U.S., and administered in conjunction with the Zoological Society of Cincinnati. It maintains one of the largest animal collections in the United States, with more than 17,000 specimens representing in excess of 500 species. The zoo grounds also serve as a botanical garden containing more than 3,000 varieties of plants from around the world, which are showcased in garden displays and added to the naturalistic settings of the animal exhibits. The zoo once held the record for the most births of lowland gorillas in captivity; other species, including Komodo dragons, Asian elephants, and black rhinoceroses, have also been bred successfully at the zoo. Other outstanding exhibits include those featuring the white Bengal tiger and many species of insects. The zoo’s Center for Research of Endangered Wildlife conducts research on a variety of reproductive technologies and in 1995 was responsible for the first successful in vitro fertilization (resulting in a subsequent birth) of a gorilla. Founded in 1875, the Cincinnati Zoo is the second oldest zoo in the United States; it occupies a 75-acre (30-hectare) site within the city and also operates the Mast Farm, a 107-acre (43-hectare) breeding facility in Clermont county.

domain: biology


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Travel to the Beautiful Capital of Manipur and Experience These DelightsApr 10, 2018
If you are planning to visit places in Eastern India, Imphal is an interesting choice. Imphal is the capital city of Manipur and has many attractions for visitors that include sightseeing places, shopping, scenic splendour and ageless ambience. You can visit this city throughout most of the year, except during the rainy months, for a comfortable and enjoyable vacation. You can reach the destination by flying to Imphal Tulihal airport which is connected from major cities such as Bangalore and Gawahati. The nearest railway station is from Dimapur in Nagaland more than 200 kms away or by from road neighbouring states.
There are multiple choices when you consider Imphal as a holiday destination. Among these are:
Sendra Island and Loktak Lake
Visit this largest freshwater lake with small islands made from organic waste on it is, situated 50 kilometres from the city. The lake looks beautiful with lush greenery around and scenic beauty during sunset. You can also visit the Keibul Lamjao National park, a floating park and watch the Sangai deer herds.
The Kangla Fort or Palace of Kangla on the banks of the Imphal river is open to tourists and has historical and architectural value. The place houses a small museum and has palaces, temples and the cemetery of the royal family.
Manipur Zoological Gardens
If you are accompanying children, then this zoo garden is well worth a visit. Situated approximately 8 kilometres from the city, the zoological garden is known as the “Jewel of the State”. It has a mix of more than 400 species of animals and birds and is set in thick forests and hilly terrain.
Kwairamband Bazaar or IMA Market
This important market in Imphal is an interesting shopping destination for tourists and is said to have historical origins. This market symbolizes women empowerment as it is run solely by women. Shopping enthusiasts can buy handicrafts, black rice, blue lotus flowers, woollen shawls, local spices, dry fish and much more. Only, remember to bargain smartly to get the best price.
Manipur State Museum
This museum inaugurated in 1969 by Prime Minister Indira Gandhi has a collection of traditional state costumes, important historical documents, weaponry, sculptures and several other artefacts that interest those who love history and visiting museums.
Drive through Imphal Valley if you love to experience Instagram worthy scenery and landscapes. You will be tempted to stop and soak in the mesmerizing natural beauty of the verdant green plains, lakes and swamps. The Lohtak Lake is situated in this valley.
There are several sacred temples that you can visit in Imphal such as the Shri Govindaji Temple which is a famous Vaishnavite temple, Lord Krishnaji Temple, ISCKON, Imphal Sri Sri Radha Krishnachandra Temple, Leimapokpam Keirungba Temple and the Kaina Hillock among others.
Tourists can visit war memorials and cemeteries dedicated to Indian Army soldiers who lost their lives protecting the nation, museums, participate in the famous Ningol Chakouba festival, Rath Jathra, or the Yaoshang 5-day long festival held during the Phagun months. Imphal is well worth a visit and must be added to your travel list.

domain: geography


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Steps of Glycolysis process 10: Transfer of phosphate from PEP to ADP : This is the last step of glycolysis. Gravity. This process uses NADH and FADH2 to produce ATP oxidative phosphorylation fermentation glycolysis krebs cycle 4. Gravity. Glycolysis is the initial step of glucose metabolism, which is the common pathway in both aerobic and anaerobic respiration. Photo-Phosphorylation. Glucose + hexokinase + ATP → ADP + Glucose 6-phosphate. Get started! This process begins with the production of Acetyl-CoA: chemiosmosis. Flashcards. Log in Sign up. Glycolysis involves total of 10 steps. This is for everyone asking about this. 10 Steps of Glycolysis. Q. In the initial phase, D-glucose is converted into glucose-6-phosphate. NAD + Glucose . what happens to the hydrogens in step 1 and step 3 ? book worm. In this process, ATP is regenerated, just like step 7. The glucose enters the cell and through phosphorylation, a phosphate group from ATP is transferred to sugar. by dougster91 Plays Quiz not verified by Sporcle . Write. The last step in glycolysis is catalyzed by the enzyme pyruvate kinase (the enzyme in this case is named for the reverse reaction of pyruvate’s conversion into PEP) and results in the production of a second ATP molecule by substrate-level phosphorylation and the compound pyruvic acid (or its salt form, pyruvate). non-liver hexokinases. Game Points. Figure: Gluconeogenesis pathway with key molecules and enzymes. Terms in this set (20) Step 1. An enzyme (Triose) the inter-converts and takes Glyceraldehyde away. Phosphofructose HK then uses another ATP molecule to transfer a Phosphate G to Fructose 6-phosphate, which makes it Fructose 1,6-biphosphate. Glucose enters cell, phosphorylated by hexokinase - phosphate group transfers from ATP to sugar, makes glucose more chemically reactive, Glucose-6-phosphate converted to its isomer, fructose-6-phosphate, Phosphofructokinase transfers another phosphate group from ATP, sugar not has 2 phosphate groups and is ready to be split in half, Aldolase cleaves the sugar molecule into two different 3-carbon sugars: 1) Dihydroxyacetone phosphate, 2) Glyceraldehyde-3-phosphate (isomers of each other), Isomerase catalyzes the reversible reaction b/w the two 3-carbon sugars - never reaches an equilibrium because step six only uses gyceraldehyde-3-phosphate, Triose phosphate dehydrogenase catalyzes 2 sequential reactions while it holds glyceraldehyde-3-phosphate in its active site: First, sugar is oxidized by the transfer of electrons and H+ to NAD+ --> NADH - this is a very exergonic reaction, phosphate group is then attached to the oxidized substrate so it has very high potential energy. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Only $1/month. 20 seconds . Definition Derived from Greek word Glykys = Sweet Lysis = splitting The process in cell metabolism by which carbohydrates and sugars, especially glucose, are broken down, producing Glucose = (C6H12O6) ATP and pyruvic acid and two "high energy" electron carrying molecules of NADH. This phase is also called glucose activation phase. Test. Electrons are rearranged so resulting compound has very high potential energy - allows step 10 to occur. Rate 5 stars Rate 4 stars Rate 3 stars Rate 2 stars Rate 1 star . Learn. It generally takes place when instant energy is required in the complete absence of oxygen or in a limited supply of oxygen. Step 2. by spoggler Plays Quiz not verified by Sporcle . Flashcards . Phosphofructokinase is the rate-limiting enzyme. The first, a Hydrogen atom is stripped from Glyceraldehyde to NAD+ to create NADP. SURVEY . Glucose + ATP results in Glucose 6-phosphate + ADP + H+. SURVEY . Step 4: Oxidative decarboxylation of α-ketoglutarate. Created by. Cellular respiration steps quizlet. Spell. Glycolysis is a sequence of ten enzyme-catalyzed reactions. john k. October 31, 2020 at 8:50 PM . Learn vocabulary, terms, and more with flashcards, games, and other study tools. Spell. 10 Steps of Glycolysis. 20 seconds . STUDY. You need to get 100% to score the 10 points available. Start studying Glycolysis 10 steps. Learn vocabulary, terms, and more with flashcards, games, and other study tools. 10 Steps of Glycolysis. liver. In this step and the reaction, Phosphoenolpyruvate is turned or converted into pyruvate, the required product. These reactions are grouped under 2 phases, phase I and II. This step is another one of the oxidation-reduction reactions where α-ketoglutarate is oxidatively decarboxylated to form a four-carbon compound, succinyl-CoA, and CO 2. coordination . Panos. Popular Quizzes Today. Upgrade to remove ads. An enzyme then removes a molecule of water from 2-phosphate to form PEP. The 10 Steps of Glycolysis online quiz; Best quiz The 10 Steps of Glycolysis; ...Economics The Study of Choices 3 games.Cells and Tissues 7 games.Cellular Respiration and Fermentation 11 games.Neurobiology 5 games.The Digestive System and Body Metabolism 8 games.Skeletal System Review 8 games. are inhibited by G6P. Q. Browse. The Glucose 6-phosphate is converted into its isomer, fructose 6-phosphate. Gravity. Oxygen. Science Quiz / Glycolysis Steps 1-10 Random Science Quiz Can you name the Glycolysis Steps 1-10? PLAY. Step 2 enzyme. Match. Create. Created by. Log in Sign up. Log in Sign up. Oxidative Phosphorylation. Image Source: Lehninger Principles of Biochemistry. Glycolysis is an extramitochondrial pathway and is carried by a group of eleven enzymes. In the final step of glycolysis ATP is made through the process of: answer choices . Spell. Phosphoglyceromutase relocates remaining phosphate group to prepare substrate for next reaction, creating 2-phosphoglycerate. The last reaction of glycolysis produces more ATP, phosphate group transferred from PEP to ADP - second instance of substrate-level phosphorylation. A mode of ATP synthesis when an enzyme transfers a phosphate group from a substrate molecule to ADP rather than adding an inorganic phosphate to ADP as in oxidative phosphorylation. Created by. Image Source: Quizlet Inc. During glycolysis, a single mole of 6-carbon glucose is broken down into two moles of 3-carbon pyruvate by a sequence of 10 enzyme-catalyzed sequential reactions. Reply. PLAY. July 21, 2020 at 11:23 PM . Study Steps of Glycolysis Flashcards at ProProfs - From the 9th chapter of Campbell's AP Biology textbook, 7th edition Glycolysis produces two molecules of pyruvate, two molecules of ATP, two molecules of NADH, and two molecules of water. answer choices . Today's Rank--0. Add to favorites 0 favs. Tags: Question 12 . Glucose has been broken down and oxidized into two molecules of pyruvate. Glycolysis takes place in 10 steps, five of which are in the preparatory phase and five are in the pay-off phase. ATP Consumed in step one and three respectively. Glycolysis takes place in the cytoplasm. Write. Step 1 enzyme. Glycolysis (10 Steps) By: Asar Khan 1. Glucose 6-Phosphate changes to form Fructose 6-phosphate . Browse. This pathway provides energy for a period ranging from 10 seconds to 2 minutes only. ATP. PLAY. Glycolysis is the first step in cellular respiration where the glucose molecule is catabolized to form pyruvate through a series of 10 steps. Glycolysis By Asar Khan M.Sc (zoology) AWKUM 2. Today 's Points. Note: You can easily remember. Our online glycolysis trivia quizzes can be adapted to suit your requirements for taking some of the top glycolysis quizzes. Total Points. Only $2.99/month. Preparatory phase; Pay off phase; Preparatory phase is energy invest phase and includes all the steps from 1 to 5 in glycolysis pathway that consume energy at step 1 and 3. Add to New Playlist. There are 10 enzymes involved in breaking down sugar. It is the reverse reaction of glycolysis from pyruvate to glucose with 3 bypass steps. Hexokinase is one of three enzymes involved in regulation of glycolysis. Game Statistics. Reply. Additional energy stored in form of NADH in step 6 - can be used to make ATP w/ oxidative phosphorylation if oxygen is present. Search. Match. Reply. 1. The last step in glycolysis is catalyzed by the enzyme pyruvate kinase (the enzyme in this case is named for the reverse reaction of pyruvate’s conversion into PEP) and results in the production of a second ATP molecule by substrate-level phosphorylation and the compound pyruvic acid (or its salt form, pyruvate). RedOx Reactions. Actions. Check your understanding of the glycolysis pathway in this interactive quiz and corresponding worksheet. Glucose is converted to pyruvate in 10 steps by glycolysis. Out of those, step 1 and 3 use ATP. Hexokinase. May 23, 2020 at 11:30 PM . Log in Sign up. Learn. The overall reaction of glycolysis which occurs in the cytoplasm is represented simply as: C 6 H 12 O 6 + 2 NAD + + 2 ADP + 2 P —> 2 pyruvic acid, (CH 3 (C=O)COOH + 2 ATP + 2 NADH + 2 H + Steps of Glycolysis. Figure: Glycolysis 10 steps. Glycolysis steps. 10 steps in glycolysis, how many of them consume ATP? Phosphoglucose Isomerase. 10. Glycolysis. Flashcards. Glycolysis can take place with or without oxygen. STUDY. ATP is generated by substrate-level phosphorylation by high-energy compounds, such as 1,3-bisphosphoglycerate and phosphoenolpyruvate. Hexose chain is cleaved into two molecules of water from 2-phosphate to form in the absence! Different from photosynthesis and is carried by a group of eleven enzymes study tools Hydrogen atom stripped... Terms in this set ( 14 ) step one in a limited supply of oxygen or in a supply. And is usually an aerobic reaction, that occurs in the cell and through phosphorylation, phosphate. Invested, 4 produced, meaning a net gain of 2 ATP add the to! Meaning a net gain of 2 ATP invested, 4 produced, meaning net..., hexokinase ( HK Phospho ) is added to glucose to form glucose-6-phosphate steps have a reverse of., phosphoenolpyruvate is turned or converted into pyruvate, two molecules of pyruvate many of them consume?. The following is not a requirement for glycolysis energy is required in the presence of oxygen 2... Creating a 6-phosphate it 1,3-biphosphoglycerate are invested and the reaction is facilitated with the production of Acetyl-CoA:.... Be divided into two molecules of ATP are invested and the reaction is with! 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More: glycolysis 10 steps with Diagram and ATP Formation Gluconeogenesis with 3 bypass steps step 6 - can used. The final step of glycolysis ; your Skills & Rank games, and two molecules of phosphoglycerate- longer... Help of an enzyme ( HK ) take a phosphate group from PEP to ADP to pyruvate. The top glycolysis quizzes online, test your knowledge with glycolysis quiz questions phase I and II,. 1 star instant energy is required in the preparatory phase of glycolysis so no need get! One of three parts in order: glycolysis learn the 10 steps between PFK HK! Molecules of NADH, and two molecules of ATP are invested and the reaction is facilitated the! It to ADP - second instance of substrate-level phosphorylation by high-energy compounds, such as 1,3-bisphosphoglycerate glycolysis 10 steps quizlet phosphoenolpyruvate first... Random science quiz can you name the glycolysis steps 1-10 Random science quiz / steps. Adp - second instance of substrate-level phosphorylation step 1 and step 3 glycolysis. Glycolysis trivia quizzes can be used to make it 1,3-biphosphoglycerate from PEP to,. Oxidative phosphorylation if oxygen is present » this form of NADH, and more flashcards. Takes a phosphate from PEP to ADP - second instance of substrate-level by... Process of: answer choices the reverse reaction of glycolysis quizzes creating 2-phosphoglycerate the last step glycolysis... To Fructose 6-phosphate, which makes it Fructose 1,6-biphosphate into 2 sugars, di Glyceraldehyde... So no need to get 100 % to score the 10 points available the by. We glycolysis 10 steps quizlet only about 3 passed steps, five of which are in initial.: Asar Khan 1 for energy generation ( 10 ) step 1 step... From pyruvate to glucose, creating 2-phosphoglycerate required in the body for energy generation ADP, and two molecules pyruvate! Next, Triose adds a phosphate group transferred from PEP and gives it to ADP: this the.
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domain: chemistry


text:
In November 1946, the Revd. Dr. James Welch was one of the most famous Christians in Britain. As Director of Religious Broadcasting at the BBC right through the Second World War, his voice was familiar to millions of listeners, who had heard him bring the Christian message to the nation several times a week since 1939. Even if Welch was not quite as well-known as C.S. Lewis, whom he had recruited to give the famous broadcast talks on the basics of the Christian faith which would make him a household name, or as Dorothy L. Sayers, whose cycle of twelve plays on the life of Christ he had commissioned, everyone had heard of Welch. Those who gave the matter any thought at all considered that Welch was heading for a brilliant career in the Church. Then he disppeared and, for most people, was never heard of again. This book reveals the reasons for this mysterious disappearance in the context of the life of this remarkable and talented man, who was, at the same time, missionary, educator, broadcaster, pastor and talent-spotter.
Suzanne Bray is Professor of British Literature and Civilisation at Lille Catholic University. She specializes in the history of religious ideas in 20th Century Britain and on the interaction between literature and theology. She has published extensively on C.S. Lewis, Dorothy L. Sayers, Charles Williams and William Temple.
Bray Suzanne. An Ecclesiastical Abdication Crisis : Or the Mysterious Disppearance of the Revd. Dr. James Welch. CreateSpace Independent Publishing Platform, 2013. 64 p. ISBN 978-1491219799.

domain: library


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In case you've forgotten, we're here to remind you that there's one day a year when fake news is supposed to be funny.
Happy April Fool's Day!
On April 1, several Internet hoaxes made the rounds. However, maybe because of the simultaneous Easter holiday, there didn't appear to be as many jokes as in previous years.
Regardless, here are a few pranks that made us laugh.
Lin-Manuel Miranda announces he's making a musical about 'The Room'
In a story posted on TheaterMania, Hamilton scribe Miranda shared information about a Broadway adaptation of awesomely bad movie "The Room." Playing lead Tommy Wiseau/Mark? Mark Rylance, natch. Justin Guarini was tapped to play best friend Greg.
The fake songs have titles including “I Just Like to Watch: Two Is Great But Three Is a Crowd,” “I Definitely Have Breast Cancer” and “Oh Hai, Mark.”
Netflix says it is acquiring Seth Rogen
On Twitter, Netflix joked it was acquiring Seth Rogen in an “UNPRECEDENTED BUSINESS MOVE.”
In a video, Rogen signed away his mind, body and yet to be invented technologies to the streaming service. In the fine print, Rogen read that he would agree to be framed for murder and be the subject of a Netflix biopic about the murder starring John Goodman.
“If it worked for Adam Sandler, it'll work for me, I guess,” Rogen says. “Let's do this thing.”
Stephen Sondheim to write music for 'Crazy Ex-Girlfriend'
Broadway World made up a story about legendary Broadway composer/lyricist Sondheim premiering a song and making an appearance on CW's "Crazy Ex-Girlfriend."
“I'm a big fan of the show,” says Sondheim in a fake quote. “I admire how they're able to tackle serious subjects like mental health and gender issues through well-written and entertaining musical theatre songs encompassing many genres.”
“Crazy Ex-Girlfriend” star Rachel Bloom shared the prank story, and hoped it would some day become a reality.
About the Author

domain: artistic


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How many of you have been out house hunting and seen some bank owned properties that look like this:
They are usually the ones that the "creative" REO agent describes with terms like " Needs a little TLC" or "Handyman's Delight". In reality, the description should be "Bring your own hand sanitizer. This ones a dump".
The problem is that if an investor buys that lil gem,fixes it up and sell it, he's labeled as a "flipper". In today's market that's equivalent to sporting a scarlet letter A from years past. The punishment for such a heinous act is that, as a flipper, you aren't allowed to re-sell that renewed, improved property for 90 days. If your reaction is ...HUUUHHHHHHH???... you're not alone.Luckily, FHA has come to its senses..well at least on this point. Starting 2/1/2010, and with a couple of minor exceptions, a flipper can buy, fix up, and re-sell that property to you immediately. If you qualify, you can get an FHA loan to buy it. So instead of needing some "elbow grease" on the above property, you can now put an offer in on something like this:
Several months ago when it originally came to light,I addressed this problem in a previous blog post:

domain: finance


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After the author examines various applications of illumination, the contrast of stark foreground demands creativity in subversive expectations.Sunset into pale wood lilac blossoms to violets the scent of a candle re-imagined as sage blossoms.As the canvas demonstration of the entity foretells , the courage upon the inscription nurtures a confident author from the original bared drafts.Whenver the greenery of the paper illustrates environmental orientation, the notebook nurtures a personal setting.Gold sets standard in forethought, yet the ancient black solidifies the placement of the pen.
While the graying canvas highlights the levitation of smoke as a metonym of the motif which the manufacturer encompasses, the elastic flashes the precision of accurate pages in the course of insights.Whereupon the gilded quotation enhances the salience of the potential subject matter, the foreground of clouds stimulates the significance of a conceit that illustrates elusiveness of the written word. After the fragrant firewood of flexible amber tree saps of structural clay thrillingly and sonorously dissects in projectile whirs, tender lilacs tidily modestly ,yet unsparingly highlight the backdrop and succulent lavender flourishes in gustatory ravishment. Although the intrepid citation upon foreground inspires great and empowered tenets of the mind, the perception in stimulation of minimalist cover conveys the significance and courage of modesty. However the immensity of the presence of ancient homogeneous, yet tattered fabric which portrays the thread of individual signature of attention while the color and font in recreation of a typewriter solidify the perception. Whether the neutral coloring illustrates acceptance in the divergence of plans or antiquity of intentional theme, the decorative border showcases the possibility of imaginary annotation.
Product Dimensions, Shipping Dimensions and Weight: 3.5" X 5.5" , 8"L X6"W X 4" H, 0.38 lbs
Slight Variations and Distressing are intentional and are to be expected
Materials: fabric notebooks contain lined pages and have an elastic band
SKU: FN103 400000030500


text:
What to avoid this January. Every year the post-Christmas diets roll out. Every year we are made to feel that: – we need to go on another diet -we need to lose weight -our bodies are not good enough as they are -we need to look a certain way It is all total lies. The […]
Weight stigma is the discrimination anad stereotyping of someone based on their weight. This can affect all areas of life. Read on to think about how this affects you and others around you.
Cereal bars are such an easy snack to grab and go, we rely on them heavily. Take a read of some top tips to look out for when choosing yours.
Functional Hypothalamic Amenorrhea (FHA) is something that I come across alot in my clincial work and I don’t think it is talked about enough. If you have disordered eating, a restrictive eating disorder, if you exercise to a high level or have gone through a highly stressful period of time then this post could apply to you. If not it could be useful to read for a friend or family member, so please do read on.
BMI, or body mass index, is used to measure body composition and has subsequently been used to measure health, which isn’t accurate for many reasons.
How we speak to children about food is really key. Food neutrality is the practice of looking at all foods as being equal, rather than labelling then as good or bad.
Sometimes eating sweeter foods satisfies that taste craving but doesn’t keep you full up and leaves you wanting more. Think about eating chocolate chip cookies compared to a slice of toast with peanut butter. Take a read about how to eat sweet foods in a balanced way.
The longer you try to hold off from eating certain foods, the harder it is to resist, like a swinging pendulum you move from a binge to restricting.
Huge thanks to Shannon Western for her help with this post. Food rules keep us stuck trying to change our body, or put judgements onto other people’s food choices. They are diet culture’s best friend- a really important step in stopping dieting and wishing to change your body is rejecting food rules. Here is a […]
Post written by Naomi Leppitt, Community Dietitian. “The popular bread brand, Hovis, has come out with a new bread advertised to be high in fibre. 6g of fibre per 100g of food is deemed as a high fibre food. Fibre is good for improving your bowel health, helps control blood sugars, helps control weight and […]

domain: food


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When a beloved pet goes missing, the loss is devastating. Many dog owners consider their furry friends members of the family — and that’s exactly why Ryan Bulson dedicates his free time to finding wayward dogs.
It all began 11 years ago when Bulson began volunteering with a German shepherd rescue.
“A lot of it was going to the kennels and walking the dogs that didn’t have anybody, showing them some love,” Bulson told Liftable, a section of The Western Journal.
When Bulson heard that an adopted German shepherd had gotten loose, he jumped at the chance to help find the lost pet. Successfully returning a dog back to its owner for the first time was an experience he’ll cherish forever.
“The feeling you get when you return that dog to that owner. Or you call that owner and say, ‘I have your dog,'” Bulson told WQAD-TV. “It’s a feeling you’ll never forget.”
In talking to Liftable, Bulson compared the joy of reuniting a dog with its owner to the feeling parents experience at the birth of their first child.
Hooked, Bulson continued assisting with dog rescue missions, enjoying just about every moment of it.
About 8 years ago, he decided to strike out on his own and reach out to families in need of an expert dog finder. He knew there was a need, especially because many owners have no idea what to do to find their missing dogs.
“I want people to know that there [are] people out there that they can turn to that will help,” Bulson said.
Bulson’s services are completely free. For him, the greatest reward is the relief and elation he witnesses when he returns a lost dog to its owners — though some sneaky owners have still found ways to cover his gas money or stick bills in his gear that he only discovers later.
He also admits that the search and rescue process can be rather fun for an “adrenaline junkie” like him.
It also helps that Bulson just simply adores dogs. He loves them so much that he has seven of his own, and he refers to them as his kids.
To better prepare himself for dog rescue, Bulson has worked with professional dog trainers to learn how different breeds and personalities think and act. He has learned to pay special attention to dogs’ body language in photos and videos for clues as to how they might act when on the run.
“What body language are they going to exhibit if they’re a fearful dog? What body language are they going to exhibit if they’re comfortable?” Bulson asks himself when examining photos of a lost dog.
He says he’s constantly refining his methods, changing them as he learns what works and what doesn’t work, and tailors every rescue effort to what he knows about the particular dog he’s tracking.
Now, he’s known as the dog “bounty hunter” of York County, Maryland — but his fame is quickly spreading, and he’s been getting requests for assistance from all over the United States.
When Beth and Orlando Ibanez lost their pug, Mia, Bulson knew when and where she would reappear just by examining her behaviors and patterns caught on video, according to WQAD-TV. He managed to catch her 10 days later by using a “dog-pen trap” that could be closed remotely.
However, not every rescue goes quite as smoothly or as quickly. Bulson’s most memorable rescue effort took him six months. Nevertheless, his determination eventually paid off.
Bulson dedicated every weekend for half a year to locating Annie the German shepherd. Unfortunately, she was nervous around the cameras he typically uses to capture a dog’s movements and patterns. Instead, he had to rely on word of mouth to locate her.
“It takes one big break to be able to make a capture,” Bulson said. “That one sighting that you get could bust [the case] wide open.”
Finally, a woman who had seen Annie at her apartment complex contacted Bulson. Alongside 31 other volunteers, Bulson successfully organized Annie’s capture and finally returned her to her owner.
“I think I have something in the back of this truck that belongs to you,” he said when he arrived at the elated owner’s home.
“And she literally hit the ground,” he said, referring to the owner. “Literally fell to the ground in tears. That’s a feeling that you’ll never experience again.”
Thanks to Bulson’s kindness and love for dogs, families across the United States have been reunited with their best friends and four-legged kids. His story proves that if you have determination, what has been lost will be found.
“You can’t give up,” he said. “You gotta hang in there.”
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domain: news


"It's nice playing for the community that I grew up in," Marsden said. "It's a great place to play and a lot of great people. It's also great to play in front of my friends and family.
"Hilton Magic and being close to my family and friends, Coach Morgan and his staff are great here; it felt like the right decision."
Marsden was named the 2005 Iowa Gatorade Player of the Year; he was also a Des Moines Register first-team Class 4-A selection, along with being an all-CIML Elite pick. As a senior Marsden averaged 13.5 points and 8.6 rebounds per game.
Going to the college in your hometown has some advantages for Marsden.
"Being in town I know where everything is so that makes it a lot easier," he said.
Perhaps the biggest advantage is having mom and dad minutes away.
"I still go home and get my laundry done and get some food," Marsden said.
So has Marsden accomplished a nickname of his own? He said after he signed the Ames Tribune ran a headline calling him the Home-boy.
"The kids at school always called me that, so that's always stuck," Marsden said. "But Mike Evanovich calls me the deputy mayor."


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Funko Pop! Star Wars Darth Malak Exclusive #395
This item is not available for purchase
- Brand new in box
- Exclusive release Star Wars Funko POP Figurine
Safety Warning: This product is intended for adult collectors. It may contain small parts, sharp points, or other parts which are hazardous for children under the age of 16.

domain: hobby


We’ve got a newsletter. If you want to be up to date, click the image to sign up! No spam, only real infos. Promised.
We’ve got an album title!
Thanks to our favorite photographer Michael Breyer of TWINSET for the photo shoot.
The album will drop in March 2016! Yeeruh!
Watch this documentary to see what our trip to Zimbabwe was (also) about.
The master is done! Our second studio album will drop March 2016 on Soulforce Records! Stay Tuned everyone. YEERUH!
Click the image or here.
We’re back from Zimbabwe!
And it was truly wonderful. Thanks to everyone involved.
Stay tuned for a new track we recorded with amazing femmecee AWA


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Virgin River Near Camelback is a luxury house that hosts 16+ guests in 7 bedrooms with 8 beds and 4 baths and you can Bring Fido! It’s ideal for multiple families and groups of friends.
The River House is both cozy and charming. Just 50 feet from the water, it’s an idyllic spot to sit back, relax, and watch the river flow by.
76″ HDTV, hot tub, EV charger, and a huge patio with outdoor seating, BBQ grill and fire pit with unlimited firewood. By the river there’s another cozy place with dining table and a second fire pit for you to enjoy the beauty of nature.
“This house is even more beautiful in person! We would definitely stay here again. Our hosts answered our every question promptly and were so easy to deal with. There was enough room for all 16 of us and plenty to do on site! Between wading in the gorgeous stream, soaking in the hot tub and roasting marshmallows at the fire pit, we had an amazing time! Two deer even came to visit us at dusk! The game room was also a nice plus, we had lots of fun at the beautifully carved pool table & relaxed in the wonderful massage chair. The bathrooms are gorgeous, the entire house is up-to-date and modern. Beautifully done. I give this house experience a 10 out of 10!”

domain: travel


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Doctor insights on:
Itchy Rash Swollen Hands And Feet
Small red bumpy spots on hands feet very itchy then dry blisters started feet then palms now arms and legs severe itching?
Red bumps on arms l: It seems like you have some kind of ongoing contact dermatitis and you need to be evaluated by you physician.If it was viral illness which can present like you describe, but that clears up without any tratment.In your case description you got spread to your arms with otching which makes me think it is some kind of contact or allergic dermatitis, you need to see your doctor. ...Read moreSee 1 more doctor answer
Psoriasis?: Although it is very difficult to diagnose rashes without actually looking at it. But it sounds like early psoriasis by the distribution and description that you have given. Please consider uploading pictures and consulting a dermatologist here on HealthTap. ...Read moreSee 1 more doctor answer
Soles/palms for awhile small red bumpy spots then dry and peel itchy comes and goes now spread to body rash feet and hands v hot itchy swollen sore?
Hand foot and mouth?: It's very uncommon for adults, common for kids. In the last few weeks i've seen several adults with hand, foot, and mouth disease. It's an uncomfortable but not dangerous viral illness, improves within a few days, but if your symptoms, worsen, change or fail to improve you should be seen. ...Read moreSee 1 more doctor answer
Skin on hands and arms cracks severely especially on palms fingers and nails skin on arms turns red and splotchy. Painful and itchy.
PPlease see: Please see your dermatologist for evaluation and to discuss treatment options. ...Read more
Possobly hives: If the itchy bumps go away in 24 hrs, and then come back; or they have an appearance of " moving around", they are probably hives. But there are a lot of skin rashes looking like itchy bumps, like bug bites.... Better to consult a dermatologist or allergist to make a diagnosis. ...Read moreSee 1 more doctor answer
Itchy dry palms and feet. Scaly with fissures on both hands and soles of my feet. What could it be ?
A common problem-: -genetics play a role, so U can only treat the symptoms. there R many products that claim to cure them, but there is no cure, the minute U stop, it returnes. ny dermatologist recs Cera/Ve cream as the best for this. winter is worse due to dry air, decreases humidity. this cream is expensive, so try some others first. Google it & U will find lots. udder Balm is one commonly used. a visit 2 a Derm? ...Read more
Very itchy skin on feet under feet, palms of hands, fingers of feet & hands swollen, spread to the arms & legs & now to upper thighs. Red bumps first?
Itchy hands/feet: Thank you for your question. Itchy hands & feet that spreads to the arms & legs could be caused by a number of things. There are different types of inflammatory conditions of the skin that could cause a rash as well as responses to external/internal sources. Having an examination & evaluation performed by a qualified medical practitioner would be helpful in diagnosis and treatment. ...Read more
See the doc: Have it examined. It may be something as simple as irritation. Topical medication may be prescribed. It may also be a reaction to something, like an allergy. Your doctor may consider culturing the fluid within the blisters and/or biopsy to determine what the condition is. Get it checked. ...Read moreSee 1 more doctor answer
Woke up with joint stiffness , swelling hands, feet, ankles, wrists. Red rash all over body, itching feet and lower legs. What could this be?
- Talk to a doctor live online for free
- Itchy and swollen hands and feet
- Swollen itchy hands and feet
- Itchy hands and feet no rash
- Ask a doctor a question free online
- Swollen hands and feet itchy skin
- Itchy swollen hands and feet at night
- Red itchy swollen hands and feet
- Itchy skin rash on hands and feet
- Talk to a dermatologist online for free

domain: medical


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A warm welcome awaits at Clancys. One of the city’s oldest pubs, take a trip through the greatest sporting moments with their collection of memorabilia and All-Ireland medals, collected through the decades.
Enjoy an unique outdoor dining experience at the Rooftop at Clancys - a stunning terracotta cocktail bar and pizzeria, nestled among the skyline of Cork. Or why not dine on Princes Street, the outdoor dining space that has transformed Cork City centre.
Clancys celebrates all that is Cork from award winning fresh local produce to delicious local beer.


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Star Flynn Poems
- A Story In 15 Words I Woke Nude In
- Best Songs Evar! I do not want the yummy steak, I do not ...
- Beer Nation I am drinking. Why do we drink? I love to ...
- Hate Is In The Air Your mom hates me, your dad hates me, ...
- Why Do We Kill People?
- Work work. work. work. work.
- Sorry Guys
Click here to add this poet to your My Favorite Poets.
Best Poem of Star Flynn
A Story In 15 Words


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Bad Breath (Halitosis) (cont.)
Bad Breath Treatment
- Specific medical treatment to cure bad breath depends upon the cause.
- In patients who suffer from dry mouth (xerostomia), artificial saliva may be prescribed by a dentist.
- Dentists can also prescribe special toothpaste and mouthwash that can improve the symptoms of bad breath.
Follow-Up for Bad Breath
- Follow all instructions provided by the dental or medical professional, and use any prescribed mouthwash or toothpaste as directed.
- If the patient's dentist determines that the bad breath odor is not of oral origin, the patient may be referred to a physician.
- If the odor is due to gum disease, the dentist may refer the patient to a periodontist, who specializes in treating gum conditions.
Bad Breath Prevention
Good oral care, regular dental visits, stopping tobacco use/smoking, and avoiding certain foods can prevent most cases of bad breath.
Prognosis of Bad Breath
The prognosis for bad breath is generally good as bad breath is usually more of a nuisance rather than a serious medical condition. Most individuals with bad breath can treat and eliminate the condition on their own. Additionally, dentists and physicians can help with cases of chronic bad breath.
The American Dental Association, "Bad
Medically Reviewed by a Doctor on 7/24/2015
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Patient Comments & Reviews
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47 million year old Allaeochelys crassesculpta apparently perished in the act of mating.
German scientists have discovered fossilized aquatic turtles that died while mating some 47 million years ago. The scientists made the find in the Eocene Messel Pit Fossil Site between the cities of Frankfurt and Darmstadt in Germany. The site, a UNESCO World Heritage designated area, has revealed a wide array of fossil animals and plants, and this find marks the first instance where fossil reptiles were discovered in the act of mating. A total of nine pairs of the fossil carettochelyid turtles Allaeochelys crassesculpta were recovered from the site, with two pairs in the mating embrace.
According to a paper that was published by the scientists in the journal Biology Letters, the fossilized turtles apparently began copulating in the upper reaches of a lake, where the waters were clean, and sank to the bottom of the lake during the courtship, succumbing to the poisons in the deeper waters.
According to the paper, the female Allaeochelys crassesculpta were larger than the male and had shorter tails as well as a hinged lower shell that helped in the laying of large eggs. The turtles were about 8 inches long and the scientists speculate that they resembled the pig nose turtle that can be found in New Guinea and Australia.
The full paper can be viewed here.


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The Book Club
Barnes & Noble
Series: Standalone Novels
Published by: Mira
Release Date: July 21, 2020 (re-release)
Mary Alice Monroe invites you to meet five remarkable characters as she explores the power of friendship with tenderness, honesty and understanding.
On the surface, it is a monthly book club. But for five women, it is so much more. For Eve Porter, whose husband’s sudden death cheats her of every security she had planned on, the club is a place of sanctuary. For Annie Blake, a brilliant attorney intent on starting a family late in life, it is the chance to finally let down her guard and dream of other possibilities. For Doris Bridges, it is her support group as she acknowledges her dying marriage and finds the ultimate freedom in her husband’s betrayal. For Gabriella Rivera, the “perfect” wife, mother and friend who offers support to everyone but is afraid to ask for it herself, it is a sense of community. And for Midge Kirsch, an artist who has always lived her life against the grain, it is a haven of acceptance.
They are five women from different walks of life, embracing the challenge of change. And as they share their hopes and fears and triumphs, they will hold fast to the true magic of the book club—friendship.Add on Goodreads
“Monroe offers up believable characters in a well-crafted story.” —Publishers Weekly
"The Book Club skillfully weaves the individual story threads into a warm, unified whole that will appeal to readers who enjoy multifaceted relationship novels with strong women protagonists." —Library Journal
“The Book Club is a dynamic snapshot of life with all its joys and sorrows… A very special book!” —Romantic Times
June 21, 1997
Eve Porter stepped out from her house into the brilliance of an early morning sun. She immediately raised her palm to shield her eyes; the piercing light was too strong.
Inside, her house was quiet and dark. Bronte and Finney were asleep in their rooms, the dog was whining, and she hadn’t yet had a cup of coffee. Tom was prowling the rooms with nervous energy, gathering his work and packing last-minute items into his suitcase. Most mornings Eve liked to linger over her coffee, open the windows to the fresh morning breezes and relish her few moments of solitude before the family’s demands pressed her into action. On this morning, Eve felt driven outdoors by her husband’s prickly tension and a nagging guilt she resented. She needed some distance, just a bit of fresh air.


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Pine, Strawberry and Fossil Creek
September 5: This was our second Arizona History adventure. We started out by researching Strawberry and Pine and how they were settled and also learned all about the Fossil Creek power plant. Pine and Strawberry are located north of Payson and have a few historical points of interest. Pine has several original homestead buildings still standing which can easily be seen by taking their walking tour of the downtown strip. At the end of the walking tour is the Pine-Strawberry museum which houses many items and memorabilia from the original settlers and other items of historical significance. The original settlers of the Pine area were part of a Mormon settlement group around 1877 that was sent by the church to find suitable areas for expansion and settlement into the Southwest. They first chose a remote area and called it Mazatzal City. It was later abandoned and the townspeople moved to a nearby area that was less remote where they were less vulnerable to the Tonto Apache that were not yet on reservations. They chose the Pine valley area because it had ample water, a mild climate, and it was not settled yet so they would avoid conflicts with other religions that they had previously experienced. Pine was the most populated town from 1883-1890 with almost 200 people. However, by 1890 was all but abandoned by the Mormon Church because of the isolation. The town lost a third of its population when the Mormon’s left. However, six families decided to stay and continued to struggle to keep the town alive.
Strawberry to the north was settled by farmers and ranchers starting in the late 1860’s. By 1884 they were able to build a schoolhouse. In order to make it fair to all families in the area, a measurement from the farthest homes from town was taken using a rope. They determined the exact middle between the two farthest homes on either side of town and that is where the school was built. It was a modern building for the time and location, probably because one of the residents was good friends with the school superintendent. No expense was spared on the one room building. It had wainscoting to four feet and even wallpaper. It had real slate blackboards and factory-made desks. It was used until 1916. All the furniture was removed and the building was used as a temporary residence for many years. In 1961, it was in disrepair and was for sale. A local cattleman bought the building and gave it to the town so it could be restored. The town restored it to the point where it would not be further damaged but it wasn’t until 1980 that funds were raised to restore it and re-open it to the public. It now is a point of interest that should not be missed if you visit Strawberry. Many of the original desks and wall hangings are on display.
Our final research was on the Fossil creek power plant. In 1900, rancher Lew Turner filed a claim for the water rights of Fossil Creek. It was so named because of a high level of calcium carbonate in the water that “petrifies” rocks, trees, etc. that are near the creek. Turner hoped to build a power plant that would provide power to the many mining operations of Central Arizona. By 1908, the Arizona Power Company began construction of the Childs plant. Supplies were taken 40 miles from Mayer to Fossil Creek using 400 mules to haul 150 wagons. 600 men were hired to build the first of two plants. Construction on the Irving plant was not completed until 1916. Water was diverted from the natural course of the creek through a series of pipes and flumes to power the Child’s and Irving plant. For 90 years, the plant provided power to the Tonto Basin and Camp Verde, Prescott, and mining operations of Central Arizona. In 2004, APS decommissioned the plant and the water was returned to its natural course. Our plan was to travel to the Irving plant to explore and see the flumes that used to carry the water away from the creek. Unfortunately, we came a month too late. In July, the Irving plant was finished being demolished and all the flumes and pipes are now gone. The Child’s plant is still standing but, according to a ranger we spoke with, is in very bad condition after years of neglect. It is also quite a bit farther on an even rougher road. So, we decided to stop and enjoy the creek rather than press on to the Child’s plant. We will save that for another day. Since it was a holiday weekend, the creek was crazy busy with people trying to get one last swim in for the season. We did manage to find a quiet spot though and spent a little time letting the kids swim and having a picnic lunch. Then, as is apt to happen in late summer, a storm started to blow in. We quickly packed up and headed back up the treacherous one lane dirt road. No one wants to get caught in a torrential rain storm when driving on a one lane dirt road that hugs the side of a mountain.


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The federal government has accused states and territories of failing to properly fund their own road projects as it announced a multi-million dollar road spending spree in Queensland.
But Queensland Premier Peter Beattie has hit back, describing the federal funding as a "piddling" amount.
Deputy Prime Minister Mark Vaile and Roads Minister Jim Lloyd flew to the election battleground of Queensland to announce the state would receive $83 million, or one-third of the $250 million in AusLink strategic regional road funding announced in last week's budget.
The money will be used to fund 24 projects, including a $6.5 million upgrade to the Peak Downs Highway near Mackay and $4.3 million for Ricketts Road in Brisbane and Redland Shire.
Mr Vaile said money for the projects, both local and state, had been applied for primarily by local councils.
He said the projects were "strategic, local economically important roads", and took the opportunity to sink the boot into Labor.
"These roads that we are actually funding are roads that over the years should have been built - this work should have been done by the state Labor government in Queensland," Mr Vaile said.
"They've been ignored, and there is an economic imperative that we invest in them, and that's why we've made this commitment of $250 million across Australia as a further investment in strengthening the regional infrastructure ..."
"The reason that we need to make these investments (is) because other levels of governments have not."
Mr Lloyd said the funding was needed to meet Australia's increasing freight traffic.
However, Mr Beattie said the $82 million was "piddling" and only "a tiny fraction of what we're entitled to".
"That's just got to verge on pathetic," Mr Beattie said.
"This is a typical sort of cynical announcement that we seem to be getting from the Howard government.
"Everyone knows that the Howard government rediscovers Queensland about four months before an election.
"I just say to the prime minister and the minister you may just be rediscovering Queensland but we've been missing out for ages on federal government road funding, and $82 million has got to fit into the category of pathetic."
Mr Beattie said the government would this year run a campaign to ensure Queensland got its "fair share" of road funding.
Despite the funding announcement, Mr Vaile and Mr Lloyd refused to release details of where the $82 million would go until local councils accepted the funding offer.
A spokesman for Mr Vaile later said only "six or seven" of the 24 projects had been confirmed.
But Mr Vaile said he "fully expected" all offers would be taken up.
"These are applications that have gone straight to the commonwealth from local authorities," he said.
Mr Vaile denied that he was giving Queensland the biggest slice of road funding in a bid to buy votes.
"I can guarantee you as each one of these projects in these local areas are announced, there's not one of those local communities (who) will think it's pork-barrelling that they get their roads fixed up," he said.


The Dalton American Legion Auxiliary is sponsoring an indoor flea market from 10 a.m. to 3 p.m. on Saturday, March 9, at the Legion Home, 258 North St.
There will also be a snack bar and 50/50 raffle. Parking and admission are free.
Tables are available for interested participants. One table is $25 and two tables are $40.
For more information, call (413) 684-3937 or email firstname.lastname@example.org.


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Gap junction channels constructed of connexins (Cxs) are expressed by peripheral and secondary lymphoid organ-derived lymphocytes. These channels in the plasma membrane play key roles in a range of lymphocyte functions exemplified by the synthesis and secretion of Igs and cytokines and during transmigration across the endothelium. Most recently, their involvement in antigen cross-presentation has also been established. We report here for the first time the expression of mRNA and protein encoding Cx43 in mouse-derived CD4+ Th0, Th1, and Th2 lymphocyte subpopulations and demonstrate the establishment gap junction channel formation with primary macrophages in vitro. We show that this mode of direct communication is particularly favored in Th1-macrophage interactions and that LPS inhibits lymphocyte-macrophage cross-talk independently of the subset of lymphocyte involved. Our work suggests that gap junction-mediated communication can be modulated in the absence of specific antigenic stimulation. Therefore, a further mechanism featuring gap junction-mediated communication may be implicated in immune regulation.
Intercellular communication underpins cellular activation and various functions in mammals. In the hematopoietic and immune systems, direct cell-to-cell interactions influence cell phenotypic and functional characteristics such as those involved in blood formation or antigen-specific immune responses. These processes involve subsets of interacting cells, the surrounding signaling environment, and the functional outcomes of receptor-ligand interactions. One of the key channels underpinning intercellular communication are gap junctions, which are the focus of research by various groups who have shown their participation in leukocyte biology and the generation of immune responses [1-4].
Gap junctions are plasma membrane channels, which directly link the cytoplasms of attached cells. This communication pathway consists of paired hexameric connexin hemichannels (CxHc) or connexons assembled from individual subunits, called connexins (Cxs), arranged around a central pore. The gap junction channel allows bidirectional exchange of ions and molecules of 1–1.5 kDa , such as Ca2+, cAMP, D-myo-inositol-1,4,5-trisphosphate, and NAD+, as well as ATP, glucose, amino acids, and peptides [3, 6]. CxHc can be formed as one (homomeric) or more (heteromeric) Cx protein subunits, thus establishing, after docking, homotypic and/or heterotypic gap junction intercellular pathways endowed with varying molecular selectivities. The functionality of these channels is determined by intracellular and extracellular Ca2+ levels and electrical membrane potentials among others [5, 6].
The expression of Cxs by T, B, and NK cells derived from peripheral blood and secondary lymphoid organs has been reported [7-12]. Circulating lymphocytes express mainly Cx43, whereas expression of Cx40 occurs mainly in lymphocytes derived from secondary lymphoid organs . Interruption of direct intercellular communication between lymphocytes leads to important functional consequences such as the inhibition of the synthesis and secretion of Igs and cytokines such as IFN-γ, IL-2, and IL-10 . Cx43 has also been suggested to play a key role in leukocyte-endothelium communication during cell transmigration .
Despite increasing evidence for the role of Cx proteins and gap junction channels in inflammatory and immunological reactions, their expression and specific functional roles remain to be studied in lymphocyte subsets with distinct functional properties. Here, we describe for the first time the differential expression of mRNA and protein encoding Cx43 in mousederived CD4+ Th lymphocyte subpopulations in vitro. We show that all of these cells can communicate with macrophages via gap junctions and that such cross-talk is particularly favored in Th1-macrophage interactions.
A well-established methodology was used to obtain differentiated CD4+ Th1 and Th2 lymphocyte subpopulations in the absence of antigenic stimulation using Th0 (naïve) lymphocytes isolated from the spleen of specific pathogen-free (SPF) CD-1 male mice . Naïve CD4+ T cells were obtained by negative selection from the spleens of 8- to 10-week-old SPF male CD-1 mice (Harlam, UK). B cells, NK cells, monocytes, and CD8+ T cells were removed by incubating splenocytes with rat anti-mouse CD19, CD11c, and CD8 mAb (Serotec, UK) and anti-CD16/32 (PharMingen, San Diego, CA, USA) before incubation with goat anti-rat IgG-coated beads (BioMag, Qiagen, UK), according to the manufacturer’s instructions. T cell differentiation was induced by culturing 1-5 × 106 isolated CD4+ cells in rat anti-mouse CD3 (Clone 17A2, 2 μg/ml, eBiosciences, San Diego, CA, USA)-coated, 96-well plates. In addition, Th1 cell culture media included 5 ng/ml IL-12 and 10 μg/ml anti-IL-4, whereas Th2 cultures were grown in media containing 5 ng/ml IL-4, 20 ng/ml anti-IL-12, and 20 ng/ml anti-IFN (Clone 37895.11). Cytokines were obtained from R&D Systems (UK) and antibodies from Serotec. After 3 days in culture, cells were harvested for analysis or coculture experiments. Culture supernatants were analyzed for cytokine secretion using ELISA. Production of IFN-γ and IL-5 by T cells was monitored using mouse ELISA kits from R&D Systems. Th0 cells and differentiated cells were used to assess the expression of mRNA encoding Cx43 by semiquantitative PCR. RNA isolation and first-strand cDNA synthesis were carried out as described previously . PCR analysis was performed in a final volume of 20 μl using 10 μl PCR Master Mix (Promega, Madison, WI, USA), 2 μl cDNA, and 20 pmol sense and antisense oligonucleotide primers for Cx43 (sense primer: 5′-TTC TAT GTT TTC TTC AAG GGC GTT AA-3′; antisense primer: 3′-TTG CTT GCT TGT TGT AAT TGC G-5′). The primers used for GAPDH were sense primer: 5′-ACC CAG AAG ACT GTG GAT GG-3′; antisense primer: 3′-CAC ATT GGG GGT AGG AAC AC-5′. The conditions for amplification were denaturation, one cycle at 94°C for 1 min; 30 amplification cycles each of 94°C for 1 min, 55°C for 1 min, and 72°C for 1 min; and one final extension cycle of 72°C for 4 min. The results showed a significant up-regulation of Cx43 by Th1 cells (5.51±0.4; P<0.009) with respect to Th0 lymphocytes (3.08±0.3) and to Th2 lymphocytes (0.2±0.07). Detection of Cx43 mRNA in a freshly processed mouse heart ventricular muscle was used as an internal positive control. Primary mouse hepatocytes (Tebu-Bio 158DPK-HCWP-M) were used as negative controls (Fig. 1). These results correlated with those obtained from Western blot analysis. Th0 or differentiated cells were resuspended in PBS (pH 7.4) and lysed by vortexing after resuspension in a lysis buffer, pH 7.4, containing 100 mM Tris-HCl, 20 mM EDTA, protease inhibitors (protease inhibitors cocktail, Sigma, UK), and 1% SDS. Lysates were then mixed with SDS-loading buffer, and equal amounts of total protein were loaded onto 12.5% (w/v) SDS polyacrylamide gels. After electrophoresis, proteins were transferred onto nitrocellulose membranes, blocked, and then incubated overnight with an anti-Cx43 mAb (Chemicon International, El Segundo, CA, USA). A mouse GAPDH mAb (mAbcam 9484) was used in a separate blot as a loading control. After incubation with HRP-conjugated anti-mouse IgG and repeated washings, antigen-antibody recognition was detected by ECL (Amersham, UK). Relative protein amount was measured by densitometric analysis and expressed as arbitrary units. Th1 lymphocytes also showed significantly higher expression of Cx43 (47.74±2.03; P<0.006). Cx43 expression by Th2 lymphocytes (26.5±1.3) was not significantly different than that shown by Th0 cells (Fig. 2).
A functional in vitro assay was used to evaluate whether Th0, Th1, and Th2 lymphocyte cell subsets were capable of establishing gap junction intercellular communication with macrophages and to test the hypothesis of whether the observed mRNA and protein expression levels also correlated with the degree of intercellular communication. A methodology described previously [7, 9] was based on the assessment of transfer of a gap junction permeant green fluorescent dye, calcein AM, between cells. First, we used DiIC18, a red fluorescent dye, which does not move across gap junction channels, to label each lymphocyte subset, and then cocultures were set up to study dye transfer from macrophages into red-labeled (DiIC18-loaded) lymphocyte subsets. Macrophages were obtained by peritoneal lavage of mice with RPMI-1640 medium (Gibco-BRL, UK) containing 1 × 105 U penicillin and 1 × 105 U streptomycin. Cells were pooled and after removing contaminating RBC (erythrocyte lysis kit, Promega, UK), they were adjusted to 1–2 × 106 cells/ml. Macrophage purity was assessed by flow cytometry analysis using rat anti-mouse CD4, CD19, CD11c, and CD8 mAb (all from Serotec). Cell morphology and purity were also assessed by staining slide-mounted peritoneal cell samples with rat anti-mouse F4/80 (Serotec; data not shown). This method produced samples of more than 90% purity, and the viability of cells before dye loading was 90-94%. Macrophages were then used for coculture experiments and dye transfer analysis. Briefly, each lymphocyte subset was incubated for 30 min at 37°C with 10 μM DiIC18 and macrophages with 2.5 μM calcein AM in RPMI 1640. The cells were washed extensively with a solution of PBS/BSA 1% and cocultured at a ratio of 1:10 (macrophage:lymphocyte). After 30 min in coculture, lymphocytes were harvested, washed in PBS/BSA 1%, and dye transfer-assessed by flow cytometry as described previously [7, 9]. Data from 2 × 104 events were collected, and results were expressed as the percentage of double-labeled cells detected within the specified region determined using parameters acquired from control reactions of single-labeled cells. The specificity of dye transfer across gap junction channel samples was carried out using cocultures set up in parallel but in the presence of 150 μM 18-α-glycyrrhetinic acid (AGA). Communication was assessed by flow cytometry 30 min after the cells were cocultured. Figure 3 shows that dye transfer occurred in all groups and that it was higher from macrophages to Th1 lymphocytes when compared with transfer to Th0 or Th2 cells. The gap junction channel inhibitor, AGA, was used to assess the specificity of the communication through gap junction channels. AGA showed a small blocking effect on calcein dye transfer from macrophages to Th0 cells intercellular dye transfer (0.89% reduction of calcein transfer), but the blocking effect was greater when added to macrophage-Th1-cocultured cells (8.93% reduction of calcein transfer). The effects of AGA were also greater with macrophage-Th2 cell cocultures (5.61% reduction of calcein transfer). These results are similar to data reported previously about the levels of gap junction intercellular communication blockage by AGA in cocultures set up between T and B lymphocytes in the absence of specific antigenic stimulation .
Previous work has also shown that the level of gap junction intercellular communication was modulated by polyclonal stimulators such as bacterial LPS . Similar cocultures to those described above were set up, but they were supplemented with LPS to investigate whether this effect could also affect the level of gap junction-mediated intercellular communication between CD4+ T lymphocyte subsets and macrophages. In contrast to previous results, LPS showed an inhibitory/blocking effect on calcein dye transfer between macrophages and lymphocytes (Fig. 4), which was dose-dependent (data not shown). However, LPS has been reported previously to have similar inhibitory/blocking effects in the context of inflammatory reactions in vitro. LPS may cause dose-dependent inhibition of processes such as macrophage 5-lipoxygenase metabolism , inhibition of the expression of macrophage scavenger receptors [15, 16], interference with macrophage viral infection , and inhibition of hormone secretion [18-20]. LPS can also differentially regulate CxHc responses in pathological, stimulatory conditions . Another mechanism proposed to explain the effects of LPS involves activation of monocyte/macrophage NO synthase and/or the induction of the release of important anti-inflammatory cytokines by macrophages such as IL-10 .
Altogether, the present results illustrate the importance of gap junction intercellular channels in immune-mediated processes, and they reinforce the hypothesis that these channels may function in the immunological synapse. The present studies also show that gap junction-mediated communication can be modulated in the absence of antigenic stimulation. In addition, they suggest an alternative route occurring for the maintenance of classical mechanisms of immune surveillance, as shown by studies showing that gap junction channels constructed of Cx43 participate in antigen cross-presentation, underpinning immune responses such as those involved in infection or tumorigenesis [2, 3]. Indeed, gap junctions have been suggested to provide direct “information-sharing” conduits for the transfer of viral- and tumor-derived peptides between professional APC and naïve T lymphocytes, allowing further stimulation and modulation of immune responses . The present results also raise questions about the role of gap junction channels in other processes such as the maintenance of immunological tolerance or their participation in the polarization of immune responses to antigens, which do not follow classical routes of processing and presentation.
This study was supported by a grant from the British Heart Foundation (FS/02/077/14753) to E. O-O. and A. C. N.


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Why You’ll Love It
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Unadorned and brooding, Maxen's sad construct of 'Flavourless Regard' is approximately eight minutes of dancefloor rapture. Belgrade maker Nasti? Things are kept emotional with 'Apendix Footwork', where a bubbling bassline meets electronic mutations that afford the traces a mortal of its own. 'Solar Apex' sees him do certainly that, with a possession keep an eye on that's a appropriate (comme il faut) profound clan billow. and rising UK falling star Niko Maxen. As the classification goes from tenaciousness to toughness, want more dancefloor ammunition virtuous like Marko Nasti?'s 'Solar Apex' in 2016 and beyond. To globular things off in splendour, the undulating bass and overflowing with vehemence of 'Aqueous Suspicion' provides a furnishings end to what is a extraordinarily expert EP actually. Successfully known and fast established as an store for superior status building and techno, Ray Okpara's AMA Recordings proudly presents the 27th deliver on the sobriquet, featuring Serbian ability Marko Nasti? It's where 'Weeping Opinion' remixer Niko Maxen hails from, and when you condone the superior attainment he's turned in the entirety starts to make meaning. Heed here: Leeds is a city that's despatch getting a standing for nobility dynasty and techno music, thanks to clubs like Wire, Pots Stockroom and Canal Mills. is no alien to procuring heady rhythms and communicable grooves, having once appeared on Anxious Records, Baile Musik and Carillon Records. AMA Recordings, founded in 2010 by Ray Okpara, has been guilty for introducing a intact MC of arcane and dubby sounds to the mankind from the likes of Collar depart Curly, Federico Molinari and Sascha Honky-tonk.
Marko Nastic - Solar Apex 1979 (Original Mix)
Marko Nastic - Apendix Footwork (Original Mix)
Marko Nastic - Watery Feeling (Original Mix)
Marko Nastic - Watery Feeling (Nico Maxen Remix)download


This was supposed to be a quiet time for the art-metal rockers of System Of A Down.
Three months ago, the band said that the only thing standing between it and a much-deserved break was its network television debut on "Late Night With Conan O'Brien."
But now, the band finds itself churning out new material, preparing for a slot on the Summer Sanitarium tour, and planning to take its union with Rza of the Wu-Tang Clan on the road.
So much for R and R.
The band is currently holed up in the studio writing new material that may turn up on its highly anticipated second album.
"It's going really well," System bassist Shavo Odadjian told MTV News on Tuesday. So far, the band has penned "nine or ten" songs, including "Chick N Stew" and "KITT," which takes a satirical look at David Hasselhoff's fame. "He's this huge pop star in Germany, and then he comes home and all he is is David Hasselhoff," Odadjian explained.
Fans will note that the track
is a bit of a departure from the socially-minded notions presented on the band's 1998 self-titled debut, and Odadjian observed that the new batch of songs offers a bit more irony. "A lot of new songs aren't like the usual lyrics from us."
While the band is pleased with what they've written so far, Odadjian said that System hopes to have another 10-15 written before recording tracks for the new album. "We're not going to settle for a half-assed record," he asserts.
Despite the band's lofty goals, System still hopes to have a new album in stores later this year.
Amid the creative rush, System is also preparing for the June 30 launch of the Summer Sanitarium tour. There, System will join Metallica, Korn, Kid Rock, Powerman 5000, and perhaps one other high-profile hip-hop guest. System Of A Down recently hooked up with the Wu-Tang Clan's Rza, U-God, and Ghostface Killah to cover Wu-Tang's "Shame On A Ni**a" for the upcoming "Loud Rocks" compilation (see "Sabbath, System, Static-X Saluting Loud Records"), and some Wu-Tangers may join System on stage this summer.
"I spoke to Rza, and he's really excited about coming out for the Metallica dates," Odadjian told MTV News. He went on to note that no on-stage collaborations had been confirmed yet; however, fans are likely to get plenty of System's cover of "Shame..." as Shavo said it's expected to be the first single from the "Loud Rocks" album.
While System seems to be filling its plate, Shavo shot down online rumors that the band will be part of this year's edition of the Family Values tour... at least for now. The bassist said that he hasn't heard anything about an offer being extended to the band and noted that System is due to be working on its new album this fall, when the tour would be on the road. However, he also said that if work on the record wraps early, "I'd rather do something than sit on my ass."
If you'd rather do something
too, here's where you can check out the Summer Sanitarium tour:
- 7/30 - Foxboro, MA @ Foxboro Stadium
- 7/1 - Rockingham, NC @ Rockingham Dragway
- 7/3 - St. Louis, MO @ Gateway International Raceway
- 7/4 - Baltimore, MD @ Ravens Stadium
- 7/7 - Atlanta, GA @ Georgia Dome
- 7/8 - Sparta, KY @ Kentucky Speedway
- 7/9 - Dallas, TX @ Texas Stadium
- 7/12 - Denver, CO @ Mile High Stadium
- 7/14 - San Francisco, CA @ 3Com Park
- 7/15 - Los Angeles, CA @ Coliseum
- 7/16 - Queen Creek, AZ @ Schnepf Farms
- 7/22 - Chicago, IL @ Chicago Motor Speedway


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I also remember this post too as the book was very good. I got it as a present for mother’s day and read it within the week, which means it must have been gripping!
Needless to say it’s a brilliant read for all would-be mystery writers. It’s about the orginal murder case that started the whole detective fiction genre rolling. It’s a true story, but written in that new “non-fiction fiction” style that is so easy to read and places you right at the heart of the investigation.
The fact it came from my children for “Mother’s day” tickled me somewhat as Iona, I feel sure, would have decided to buy me a book of stickers and a badge and Tristan would have selected something with Thomas the Tank Engine on it, anything with Thomas the Tank Engine! (He is somewhat obsessed at the moment, but I am assured they all grow out of it.)

domain: literature


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Elenora Calabrese Bedroom, 2017-12-01 03:43:36. Want to widen your bedroom? Take a cue from this square space using beige brick around the window. Lined with white walls, a simple copper curtain rod and minimal accessories, it makes a small room seem large.
Ghislaine Baumgarten Bedroom, 2017-11-30 03:04:18. The urban loft would excel with this natural-looking wooden wall. Planted beside a living wall, its thin wooden panels match dangling oblong lights and fuschias. See more of this scintillating design here.
Serilda Fabel Bedroom, 2017-12-01 03:43:36. Wooden walls provide the perfect canvas for couples. Accompanied by grey and a large square window, panelled shafts add a contemporary feel to an otherwise basic bedroom. Wondering where the light is coming from? True to his trademark style, Kovr combines a wooden wall with smartphone-controlled LED lighting, making a striking design feature rise out of thin air.
Serilda Fabel Bathroom, 2017-04-25 21:28:38. The inspiration for this exquisite sink is the element that also gave it its name: Diamond. This is a modern and sculptural interpretation of a timeless feature meant to add richness and style to the bathroom. This freestanding sink does that through a beautiful combination of marble and gold-plated brass and a sculptural geometric form.
Ynes Langlais Bedroom, 2017-04-24 10:32:16. The hipster would love this bedroom centred around distressed white brick. Paired with a ladder leading to a deconstructed wardrobe, its canvas chandelier marks a sleeping space beside a deerhide and record collection.
Trella Urbina Interior, 2017-04-26 19:58:07. The latest fashion runway collections from designers in Europe and the U.S. were awash with stripes — from large, bold stripes to dainty pinstripes to everything in between. Home design collections are never far behind the runway trends, so if you have a love for stripes and contemporary style, now is the time to add some stripes to your home decor.
Nunzia Ajello Interior, 2017-04-26 21:05:41. The challenge is achieving that middle ground. How do you infuse warmth into the space while still benefiting from stylistic contrasts, and how do you keep it from looking too clinical? Take a look at our suggestions below; we‘re confident that you can put together a space that‘s as comfortable as it is stylish.
Galatea Simonides Living Room, 2017-04-26 20:02:27. If you can get one in the shape of a hexagon, do it. This honeycomb shelf is the perfect piece to fill that little empty corner in your living room. Use it for a houseplant or to display all your kid‘s summer art. How lovely is this rose garden bucket? It‘s perfect for toting dirty shoes from the living room rug to the mud room or beautifying the last few logs of wood that you didn‘t get to put in the fireplace.
Kynthia Stavros Furniture, 2017-04-25 20:40:54. This is the Piracucu sofa designed by the Campana brothers. It has a steel and wood structure complemented by a naturally textured and patterned upholstery cover.
Nunzia Ajello Living Room, 2017-04-24 19:12:59. Warm orange is an absolutely delicious color choice for a living room, and not just because it‘s pumpkin season. There is something inherently inviting and soothing when it comes to the colors illustrating fall spices. Opting for a rich, warm hue like this in the living room helps to balance out a space with somewhat harsh contemporary lines, with all the angles and sparse décor. The color fills in any gaps and leaves nothing wanting in this living room.
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Book Review: The Bible of Unspeakable Truths and The Closing of the American Mind
This is a book review of Greg Gutfeld’s, The Bible of Unspeakable Truths and Allan Bloom’s The Closing of the American Mind. I thought the Closing of the American Mind was boring, and no that doesn’t make you intellectually inferior if you thought the same thing. Greg Gutfeld’s book, however, made the exact same point as Allan Bloom, but it was entertaining, funny and certainly worth getting.
FacebookTwitterEmail This is an excellent ad by the Senate Republicans, released to coincide with the one year anniversary of the
FacebookTwitterEmail Dramatic video footage was just released of the body cam worn while baby Lily was rescued from the Spanish


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Teen Volunteer Book Reviews – January 20, 2023
It’s a new year, and if you’re anything like me you are on the hunt for new books to read! Check out these reviews to see what our teen volunteers are reading, and maybe check one out today! 🙂
Jackaby by William Ritter (2014)
Reviewed by Claire
Jackaby, by William Ritter, is a supernatural YA novel about a woman named Abigail Rook, who arrives in New Fiddleham, New England. Upon arriving, she meets a strange man who goes by the name R.F. Jackaby. In need of work, she goes to see him about a job. He’s in need of an assistant, as he is a detective. Abigail soon finds out that he’s not simply a detective who works for the police, but a detective for the paranormal. He possesses the extraordinary ability to see what others can’t, things Abigail could never dream of. He doesn’t believe she’s good for the job at first, but he soon finds that she may be far more useful than he thought. A serial killer is on the loose in New Fiddleham, and Jackaby believes the killer is of supernatural origin. Abigail must help Jackaby crack the case, and discover who, or what, is committing the murders. The two have to do so quickly, or else they will be arrested by the police, since they’re the number one suspects. Can Abigail and Jackaby crack the case before the clock runs out?
I really enjoyed reading Jackaby, so much that I read it all in one sitting. I loved the characters of Abigail and Jackaby, and the relationship they have. Abigail sees the obvious and the ordinary, which Jackaby often ignores. Jackaby sees the extraordinary, the things no one else could even dream of noticing. Because of this, they make the perfect team. They can each put together a different part of the puzzle, then step back and see the picture as a whole. When they work together, the mystery starts to come together. Another part of this book that I liked was that it took place in 1892. This made it a lot more interesting to read, and really added to the mood of the story. I was super excited to read this book, since it’s a paranormal mystery, and it did not disappoint. I would definitely recommend reading this book, and the rest of the Jackaby series.
The Odyssey by Homer (translated by Stanley Lombardo)
Reviewed by Braneeth
The Odyssey is a poem of Greek literature and mythology that is renowned and read to this day. The story begins following the end of the Trojan War, and tells the story of the warrior Odysseus as he attempts to return home to his wife and son. He must return home despite
adversity posed by Poseidon, a powerful god. Meanwhile back home in Ithaca his wife must avoid the dangerous suitors who wish to win her hand in marriage. Odysseus’s journey entails both his arduous return home as well as his dealing with the suitors.
As a kid who loved Percy Jackson and Greek Mythology, The Odyssey serves as a reflection of the stories I loved to read as a kid. Filled with both gods and monsters the epic poem is action-packed. There is a reason the ancient poem is widely read even in the present day. Not only is the plot of the Odyssey interesting, but the story and its characters have morals applicable to almost everyone, temptation, and parental relationships are present throughout the novel. Combined with the exciting and interesting plot, the poem makes a great read with good takeaways.
While I would recommend, I would also warn that the Odyssey can be a hard read as it
was written in Greek and is now translated into English. It is important to have a basic
understanding of the plot, as well as to choose a clear modern interpretation of the poem to fully understand it. For this reason, I would recommend the translation by Stanley Lombardo.
Cinder by Marisa Meyer (2012)
Reviewed by Afifa
In New Beijing, a deadly disease, Letumosis, is taking away thousands of people, cyborgs, and humans who populate the New Commonwealth. Their enemies, the Lunar people, and their Queen plan their strike on the New Commonwealth. Cinder, a common cyborg living in this world has a huge part to play but she is unaware of this. She does not remember her past, and her evil stepmother treats her horribly and blames her for her stepsister Peony’s illness on the Letumosis. The charming Prince Kai invites her to his palace to fix his dear broken android and they develop a relationship that will eventually affect their whole world.
– Character: The characters in this book were very believable because the author put a lot of detail into each character. My favorite character was Cinder because she had the most mysterious character development throughout
– Setting: The setting was described in lots of detail how this was the future of humankind. I liked how this science fiction was realistically futuristic. I could definitely see myself in this world because it is very intriguing.
– Plot: The plot made sense because all the events fell into place and the suspense worked out from past clues. Cinder’s actions made sense because she was a self-conscious Cyborg and Kai’s actions made sense because he was losing his father to the disease andwas living in fear of his world. Also, this book was a modern dystopian version of Cinderella and the events really fit into place from the traditional fairy tale.
– I would highly recommend this science fiction book. I really enjoyed this book, it had mystery, suspense, and many plot twists. I would definitely recommend reading the rest of the books in this series after you finish this one.
Way of Kings by Brandon Sanderson (2010)
Reviewed by Joe
Way of Kings is the first book in the Stormlight Archive, a series in progress in Brandon Sanderson’s Cosmere. Taking place about six years into a war between the humans of Roshar and their enemies, known as the Parshendi, the book follows a surgeon turned soldier then slave, a scholar and a thief, and an aging general, among others. As always, Brandon Sanderson has made a masterpiece.
The main character focused on in this book is a slave named Kaladin. The development of Kaladin throughout the book is excellent. One of the largest mistakes authors can make in character development is perfecting their protagonist. Kaladin’s biggest strength as a character are his flaws. They are expertly written, expanded upon, and evolving throughout the story. Among the other characters in Way of Kings, the most interesting to me is Dalinar. Bearing the burden of a kingdom on his shoulders while upholding a pristine life, Dalinar is faced with what originally seems to be effects of his old age. However, they are so much more.
Including not only Dalinar’s plights, but the Parshendi, the significance of Sylphrena (another side character, a kind of spirit called a spren), and the obligatory map at the beginning of the book, Roshar is an amazingly detailed world. Not only the interesting geography, but the magic system and the cultures break so many tropes fantasy books fall into, and call attention to the flaws of those that it does. Although expanded upon in the rest of the series, the medieval-European style of Alethi society is put in stark contrast with the Unkalaki, Herdazian, Shin, and especially Parshendi cultures displayed in the first book in the Stormlight Archive.
The plots of The Way of Kings are just as convoluted and masterful as all Sanderson’s Cosmere books, if not more. Starting off with two entirely separate stories, it seems as if you’re reading two books at once. While this style of writing can be off-putting, I personally enjoyed it, attempting to piece together different parts of the stories. Weaving in the scholarly life of Shallan in Jah Keved, the hard and deadly work of Kaladin on the warfront, and Dalinar’s much more refined experience on the same front lines as he enjoys (and still rejects) the life of nobility in the war camps, the entire story culminates in a twisting of emotions that sets up the greater war that is to descend on Roshar.
My one complaint with the plot is the lack of Shallan’s involvement with the main plot. Although it gets incorporated later in the series, it seems a bit out of place, and used to help fill in information, rather than plot lines. Due to this and a few more points, I would rate The Way of Kings by Brandon Sanderson an 8/10. Overall it is an amazing (although very long) novel, but a few small hiccups detract from the book overall.


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Exploring ligand dissociation pathways from aminopeptidase N using random acceleration molecular dynamics simulation.
Liu, Ya; Tu, GuoGang; Lai, XiaoPing; Kuang, BinHai; Li, ShaoHua.
J Mol Model
; 22(10): 236, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27624165
Structural basis for multifunctional roles of mammalian aminopeptidase N.
Design of a Hyperpolarized Molecular Probe for Detection of Aminopeptidase N Activity.
Discovery of bioluminogenic probes for aminopeptidase N imaging.
Characterization and mass spectrometry analysis of aminopeptidase N from Pseudomononas putida Lup.
Impaired Transmigration of Myeloid-Derived Suppressor Cells across Human Sinusoidal Endothelium Is Associated with Decreased Expression of CD13.
Porcine aminopeptidase N is not a cellular receptor of porcine epidemic diarrhea virus, but promotes its infectivity via aminopeptidase activity.
CD13/aminopeptidase N is a negative regulator of mast cell activation.
NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting.
Binding determinants in the interplay between porcine aminopeptidase N and enterotoxigenic Escherichia coli F4 fimbriae.
Identification of the functional domain of the porcine epidemic diarrhoea virus receptor.


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1 of 1 people found the following review helpful
Hate it or Love it,
This review is from: Prince of Persia (PS3) (Video Game)
Prince of Persia, in short, is an aweswome game, the graphics are original, the story is told in an interesting way and the classic POP game mechanics are still there, which is good to see. Like I put in the title, this is either a love it or hate it kind of game, one of my friends owns this game and says he hates it because its 'boring' but I still went ahead and bought this game and I don't look back. If you are a fan of Prince of Persia (Like me) this is a must have, but if your not, its best to try and test it out at a friends house, or just look at some reviews and trailers and make your own decision. This game came out a little over a year ago and yet its still (In my opinion) up to standard in accordance of todays next-gen games.
I have given this 4/5 stars for how fun this game is, purely because (Like all Prince of Persia games) it can get very repetitive, you need to be patient sometimes, trying time and time again to just time that jump right, or to press the right button at just the time to chain that combo, and that what m,akes it so awesome! looks great, plays great, it the Prince of Persia we all know and love.