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The EESC NAT Section and its Sustainable Development Observatory take part in the #IWD2021 action!
Equality between women and men – too little progress!
Equality between women and men is a fundamental value and objective of the European Union, enshrined in the European treaties and the Charter of Fundamental Rights and most recently reaffirmed in the European Pillar of Social Rights.
While there are numerous positive initiatives within Europe to tackle various aspects of gender inequalities, the drivers for true equality, especially within the Member States and regions, are complex and multi-faceted. Despite the general progress that has been made, the EESC regrets that, at the current rate, it will take over 100 years to achieve gender equality in the EU.
The EESC has called for an overarching strategy for sustainability in implementing the 2030 Sustainable Development Agenda. In this context, the Committee believes that the EU and its Member States must make every effort to achieve SDG 5 on gender equality by 2030.
Gender equality, the labour market and COVID-19
As we already reported last June for the World Population Day, according to the Eurostat Sustainable Development Goals monitoring report, for SDG 5 (gender equality), the overall development was negative. In fact, it is the only SDG for which the EU moved away from the goal over the last five years.
In the labour market, European women continue to face persistent gender inequalities, segregation and a gender pay gap, which leads to women being at greater risk of poverty. Women are over-represented in part-time employment and their choice of part-time work is often influenced by caring responsibilities. The share of involuntary part-time work has decreased only slightly (0.1%) in recent years.
The COVID-19 pandemic had a disproportionate effect on women. During the COVID-19 recession in the United States, women’s unemployment rate rose by 12.8 percentage points between February and April 2020, 2.9 percentage points larger than men’s increase of 9.9 percentage points. Moreover, the increase in childcare needs due to lockdowns affected women more than men. In Europe, Eurostat data show that, between April and September 2020, more women than men lost their jobs. The pandemic also pushed more women than men into inactivity (meaning, effectively, that they dropped out of the labour market). Overall, women have struggled more than men to balance their professional and personal lives during the pandemic.
According to the UN SDSN Sustainable Development Report 2020, short-term impacts of Covid-19 on SDG 5 can be negative due to possible disproportionate economic impacts on women (e.g., job losses, poverty) and other social impacts on women from the lockdown (e. g., domestic violence).
Last but not least, the current backlash against women's sexual and reproductive health and rights in Europe has serious implications for women's human rights and a general threat to the universality of human rights.
Gender equality and the climate and environmental crisis
Gender inequality has been linked to environmental degradation. The United Nations Development Programme’s 2011 Human Development Report found that when gender inequality is high, environmental factors such as forest depletion and air pollution are as well. Climate change disproportionately affects women, particularly poor women in developing countries. The IPCC found that gender inequalities are further exaggerated by climate-related hazards, and they result in higher workloads for women, occupational hazards indoors and outdoors, psychological and emotional stress, and higher mortality compared to men. Climate change has also been linked to gender-based violence, as increases in natural disasters limit access to resources, and violence against women is used to enforce gender imbalances for control of resources in these situations.
However, women can also be a key to solving climate problems. Empowering women represents a major opportunity in striving to reach the objectives of the Paris Agreement. For instance, empowerment of women farmers, increased global access to family planning, and the right to an education — were the necessary changes proposed by Project Drawdown that could improve gender equality with huge benefits for the climate.

domain: sociology


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FOR IMMEDIATE RELEASE
WASHINGTON, D.C. – Today EMILYs List, the nation’s largest resource for women in politics, announced that Michigan state Sen. Sarah Anthony is the winner of the 11th annual Gabrielle Giffords Rising Star Award. EMILYs List President Jessica Mackler released the following statement:
“State Sen. Sarah Anthony is a shining example of the undeniable power of Democratic pro-choice women who run, win, and change the world. She is a groundbreaking champion for women in Michigan and beyond, and she has been a staunch defender of democracy, reproductive freedom, quality education, and working families. Sen. Anthony represents all of the tenacity and civility that the Gabrielle Giffords Rising Star Award stands for. We are thrilled to honor her with this year’s award because we know that her future is bright. No matter where she goes, Anthony will always fight for our rights with grace and determination, serving as an inspiration for the entire EMILYs List community and for generations of powerful women legislators to come.”
Sarah Anthony is a Michigan state senator who ran for office to fight for equity and opportunity for all Michiganders. Anthony is a native of Michigan’s capital city who graduated from Lansing Public Schools and holds bachelor’s and master’s degrees from public Michigan universities. She returned to her hometown to work on various progressive campaigns, serving as a community organizer and eventually as a legislative staffer in the Michigan Legislature. She has been a groundbreaker throughout her career, becoming the youngest Black woman to serve on a county commission in the United States, the first Black woman to serve as mid-Michigan’s state representative and state senator, and the first Black woman to lead the powerful state Senate Appropriations Committee. She is known as a fierce advocate for women and girls, leading legislation to end child marriage in Michigan and codify rights for reproductive health care, as well as passing the Michigan CROWN Act, which ends hair discrimination in the Great Lakes State. Anthony was endorsed by EMILYs List in 2018 and 2022.
Named in honor of the dedicated and courageous Gabrielle Giffords, the Rising Star Award celebrates an extraordinary woman serving in state or local office. The award honors a woman who demonstrates the sort of commitment to community, dedication to women and families, and determination and civility that have been the highlights of former Rep. Gabrielle Giffords’ career, in and out of office. Previous Rising Star Award recipients include: former Georgia House Minority Leader Stacey Abrams in 2014; former Boston City Councilwoman, U.S. Rep. Ayanna Pressley in 2015; former Colorado House Speaker Crisanta Duran in 2016; former Philadelphia City Councilwoman Helen Gym in 2017; Cook County State’s Attorney Kim Foxx in 2018; California Assemblywoman Wendy Carrillo in 2019; former Ohio House Minority Leader, U.S. Rep. Emilia Sykes in 2020; Harris County, Texas Judge Lina Hidalgo in 2021; former Georgia state Rep. Bee Nguyen in 2022; and Florida House Minority Leader Fentrice Driskell in 2023.
EMILYs List, the nation’s largest resource for women in politics, works to elect Democratic pro-choice women up and down the ballot and across the country with a goal of fighting for our rights and our communities. Our work is centered around a fundamental vision: Run. Win. Change the World. EMILYs List has raised $850 million in service to that vision and has helped Democratic women win competitive elections by recruiting and training candidates, supporting and helping build strong campaigns, researching the issues that impact women and families, running one of the largest independent expenditure operations for Democrats, and turning out women voters to the polls. Since our founding in 1985, we have helped elect the country’s first woman as vice president, 175 women to the House, 26 to the Senate, 20 governors, and over 1,500 women to state and local office. More than 40% of the candidates EMILYs List has helped elect to Congress have been women of color. Visit www.emilyslist.org for more information.

domain: news


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What do Kamen Rider Drive, Spyro The Dragon, Super Mario Bros, and Buzz Lightyear of Toy Story all have in common? They each have their own line of video game gimmick figures. Let’s rewind it back to December 2014. Bandai Namco had just pumped out another game for their live-action Kamen Rider franchise on TV in Japan, this one with a slight twist. Bandai Namco wanted to hop in on the gimmick figure market much like like its competitors at Skylanders, Amiibo, and Disney Infinity, so they made Kamen Rider Summonride. Unfortunately, due to poor game design, bad controls, and the fact that the figures are extremely lackluster, Summonride fell flat.
It’s time to pick up that Dualshock 3, and watch as our Friends of Justice at Fighting Frogs Ultra attempt to get down and dirty with some of our favorite heroes in Kamen Rider Summonride.

domain: hobby


The City of Somerton developed an identity that unifies the community to appeal to visitors, new residents, and new businesses. Due to the evolution of economic trends and residents’ needs, the city held community meetings to answer this question: “Who are we”? The intent was to bring meaningful buy-in and value to the community and its stakeholders.
Liza Noland, Director of Rural Programs, with Local First Arizona and community branding expert, held a series of community meetings to obtain input from a diverse array of attendees to delve into the authentic identity of the City of Somerton. A content style guide was developed as a tool for marketing and messaging to help convey the unique aspects of all that this community has to offer and to achieve the City's goals for Family, Tourism, and Commerce. This article highlights Strategy One: Family.
Participants provided historic value about Somerton, current thoughts, and what they would like to see in the future. From those conversations, the “Vision Key Principles” were created, and the Community Vision was born, a unique image of the future.
Vision Key Principles
- Somerton is a peaceful, well-planned city consisting of good neighborhoods with a great sense of community
- Somerton is an inclusive community with strong values that honors its cultural diversity and heritage
- Somerton is a safe community with a low crime rate and exceptional public safety services
- Somerton is a community with excellent schools that prides itself on providing and sustaining strong educational values and academic excellence
- Somerton will continue to stay true to its agricultural roots while diversifying economically and creating jobs so future generations may return home to raise their families
- Somerton has a spirit of leadership, promotes entrepreneurship and is a place that residents love to call home
- Somerton will focus on specific, quality growth in targeted areas that can be supported by existing infrastructure or currently ongoing improvements
- Somerton will strive to further enhance its excellent education status by working with the school district to locate a new high school in the city and support advanced education opportunities
- Somerton will look to improve its recreational opportunities by co-locating a major Community/Regional Park with the new high school
- Somerton will focus on revitalizing its existing downtown district by filling vacant storefronts and increasing the uniqueness and economic diversity of its business community and historic neighborhoods.
The key principles are the foundation of the three strategies that were developed – “Family” – “Tourism” – “Commerce”. The “Strategic Objectives” were to:
- External partnerships that enhance awareness of Somerton
- Regional economic development initiatives
- Long term viability of existing and potential businesses
- Local business advocates to engage with the Somerton plan
- Strategies that extend the Somerton experience following events
- Signage and outreach that draw peopleintoSomerton
- Downtown experience
- Special events
- Cultural heritage and historic character
- Local pride and quality of life
- Experiential tourism
- Recreation and community service programs
- Digital footprint
- A strong, unified Somerton community
- Safe and welcoming environment
- Community events statewide and inside the community
- Downtown Somerton as a center of commerce and culture
- Small business expansion and growth
- Spirit of leadership / Heritage stories
Strategy One: “Somerton | The Best Little City for Family.”
Historic buildings on Main Street house the passion and fortitude of Somerton’s most energetic entrepreneurs lush. Green fields flourish nearby with fruits and vegetables are grown to sustain both local appetites and nationwide economies. A community rich in heart and heritage come together to make Somerton the best little city in Arizona. Somerton is a true hometown, where families thrive, education is supported, and heritage is preserved. It is a place where local roots are as deeply seeded as the surrounding crops that continue to nurture a community once built on agriculture. Stories abound from locals with deeply embedded roots that can be traced back generations, while a new generation of residents begin their own Somerton story. Whether you were born and raised in Somerton, or are in town for a festival or event, all are greeted with the same friendly, welcoming attitude that makes the community feel like one big family.


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text:
The total number of COVID-19 cases in the United States surpassed 7 million Friday, and its related death toll crossed the 200,000 threshold Tuesday, showing the country’s battle against COVID-19 is a miserable failure, U.S. experts have told the media.
U.S. COVID-19 case count rose to 7,005,746, with the national death toll reaching 203,240, as of 2:23 p.m. local time (1823 GMT), according to the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University.
California reported 801,006 cases, the highest among all states. Texas registered 747,491 cases, followed by Florida with 695,887 cases. The caseload of New York State exceeded 450,000. Other states with over 200,000 cases include Georgia, Illinois, Arizona, North Carolina and New Jersey, according to the CSSE.
U.S. COVID-19 cases topped 5 million on Aug. 9, and hit 6 million on Aug. 31.
By far, the United States remains the world’s worst-hit nation, with the most cases and deaths, making up more than one fifth of the global caseload and death toll, respectively.
“It is completely unfathomable that we’ve reached this point,” Jennifer Nuzzo, a public health researcher of Maryland-based Johns Hopkins University, was quoted by the Associated Press as saying eight months after the epidemic broke out in the world’s largest economy.
“We have from the very beginning lacked a national testing strategy,” Nuzzo said. “For reasons I can’t truly fathom, we’ve refused to develop one.”
The number of deaths is still increasing at a rate of nearly 770 daily on average, according to Johns Hopkins University.
“We’re on track to have a quarter-million dead Americans by the end of the year with absolutely no reason it had to happen,” Jeremy Konyndyk, a senior policy fellow at the Center for Global Development, was quoted by The Guardian as saying.
“It was all preventable. So yes, this is a leadership failure of astounding proportions,” Konyndyk said.
Back in March, Konyndyk told The Guardian that Washington’s response to COVID-19 was “one of the greatest failures of basic governance in modern times.” With an astonishing death toll of over 200,000, Konyndyk said his previous judgement “has borne out extremely well.”
The arrival of the fall semester combined with the flu season has sparked great concern over an uptick in new cases around the United States.
Robert Redfield, director of the U.S. Centers for Disease Control and Prevention (CDC), told the Senate Health Committee in a hearing Wednesday that more than 90 percent of the U.S. population is susceptible to COVID-19, citing a study conducted by the agency.
In addition, an ensemble forecast released Thursday by the CDC predicted that the virus may have caused a total of 214,000 to 226,000 deaths in the United States by Oct. 17.
“All the world’s leaders took the same test, and some have succeeded and some have failed,” Dr. Cedric Dark, an emergency physician at Baylor College of Medicine in hard-hit Houston, was quoted as saying by the Associated Press. “In the case of our country, we failed miserably.”


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text:
A vital national charity has secured its new North East home following another successful letting by Naylors.
Our Office Agency team has brokered a successful letting in Durham to an expanding technology firm.
Our Office Agency team has brokered a successful letting in South Tyneside to an innovative firm operating in the 'Software as a Service' sector.
The letting of a second floor suite at Queens Park marks the growing strength of the Team Valley office market.
Looking for an update on the market? Find out what's happening in the Investment, Industrial and Office sectors with our latest North East Market Bulletin.
A new marketing video has been released by the developers behind one of the regions largest new mixed-use development projects.
This Spring we are heading to MIPIM, the worlds largest property event to help showcase the North East
Will you be looking for new offices in 2019? To help you make a success of your office move, here are some important tips from our office agency team.
Naylors has secured the first letting at 2 Collingwood Street since the building underwent a major refurbishment in 2018.
A new community sports centre could result in Olympic glory for the Hebburn community after a deal secured by commercial property specialist Naylors.

domain: geography


Helpful Information About Cycling in Metro Vancouver
Buying a Bike
Bike Safety Tips
The Metro Vancouver Cyclist's Handbook available in five languages, reaching new communities with mobility choices.
Protect Yourself Against Bike Theft
Watch our bike theft prevention video to learn how to prevent bike theft. The Canadian Police Information Centre maintains a list of stolen bike serial numbers; if you buy a bike privately, check to make sure it hasn't been listed as stolen.
Recreational Cycling Groups
Maps & Route Planning
Regional Links & Connections
Getting through the George Massey Tunnel
The George Massey tunnel runs under the Fraser River to connect Richmond and Delta. Many people use this route to reach the Tsawwassen ferry terminal for Victoria. However, bicycles are not permitted in the tunnel. Cyclists have two alternatives:
Going over the Golden Ears Bridge
The Golden Ears bridge connects Langley to Pitt Meadows. Select link below for a cycling map of the new Golden Ears Bridge facility. Please note that the Golden Ears Bridge is part of a long term concession agreement which includes the ongoing operations, maintenance and rehabilitation of the bridge (for the next 30 years). The bridge is being maintained by Capilano Highway Services on behalf of the Golden Crossing General Partnership. Matters related to the operations or maintenance of the facility should be forwarded to Capilano Highway Services 604.983.2411.
Getting to the ferries
There are two ferry terminals out of Vancouver: Horseshoe Bay (to the north) and Tsawwassen (to the south). Bikes are allowed on ferries, and it's a great way to see southwestern B.C. including Vancouver Island. Plus, you can take your bike on the bus to get to them. From downtown Vancouver, bus #250 or #257 will take you to the Horseshoe Bay Ferry Terminal, and Canada Line Skytrain to Bridgeport station, with a transfer to #620, will take you to the Tsawwassen Ferry Terminal.
If you want to ride all the way to the ferry, your best bet is to pick up a copy of the Greater Vancouver Cycling Map and Guide (but note the George Massey Tunnel above if you're going to Tsawwassen).
Getting to the airport
From downtown Vancouver, take the Ontario Bike Route and then the new Canada Line Pedestrian Bike Bridge to and from Vancouver International Airport.
Local Government Bike Info, Problem Reporting
Links to pages of cycling information hosted by municipal, regional and provincial governments.Click here to report a problem on a local bike route.
Local Elected Officials
It's important that your elected officials understand what you care about; they're in office to represent your needs, and you don't need to be an expert to contact them. Writing emails or letters to officials makes an impact.
Mayor & Councils
Provincial Government Transportation Elected Officials
Cycling & Active Transportation Groups
Newspapers & Periodicals
Show your support for cycling by writing a letter to the editor or an opinion editorial. Sharing your personal stories and opinions in local media is a powerful way to shape the conversation about cycling in our cities.
Province Wide Newspapers
Lower Mainland Community Papers
Community Bike Shops
Have a used bike to donate? Want a space to do your own repairs? Check out the following community cycling resources:
Kickstand Bikes is a cycling resource centre promoting bike advocacy though education, mechanics and creativity - 1739 Venables Street at Commercial Drive.
Our Community Bikes is one of the original community bike shop projects in North America, where you can learn about bicycle mechanics, source new and used parts, and buy refurbished bikes - 2429 Main Street at Broadway.
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text:
Life is simple
Love is simple
But we, humans, make it so confusing
Always choosing the hard way
We remain angry when we could be cool
We’re stubborn when we could just let go
We’re spiteful when we should forgive
We judge our partner
When we’re not perfect ourselves
We remember things we could forget...
What a stupid game,
Life is too short to waste your time arguing about the colour of the sky
Then we break up…and make up…again and again
Where are we going?
What are we doing?
Will it ever end?
Love should be blind enough to let you close your eyes when it’s ugly
High enough to climb a mountain
Hot enough to warm the coldest nights
Humble enough to bow
Kind enough to share
Brave enough to dare
Soft enough to care
Love should feel like what we see in the movies and the books
Love should be everything and everywhere.

domain: literature


text:
This tri colored dip dye/burn out combination is a Gypsy 05’ masterpiece! With colors ranging from Wine to Blue, Grey, and Brown you are sure to find the right combination for your signature style. The wrap top is a perfect splash of color to any tank top and will go beautifully with a pair of jeans and fun accessories.
• 100% sheer Cotton, Machine wash.
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• Made in Hollywood CA, U.S.A

domain: design


text:
YORKTON - Anna Schaab has become rather well-known locally as the garlic lady because she has grown the popular bulbs and marketed them from her farm near the city for years.
But who would have expected that growing garlic would take Schaab down the path of becoming a children’s author.
Yet, that is what has happened as Schaab has written and released ‘Anna the Garlic Farmer: Just Be Yourself’.
The book is for an audience ages two-to-seven, but Schaab said she didn’t find writing for a younger audience difficult at all.
“I’m a kid at heart,” she told Yorkton This Week.
They say inspiration comes from some unusual places, and that seems to fit in the case of what inspired Schaab to tackle the book.
“This book was inspired by being interviewed by Jenn Sharp, author of Flat Out Delicious,” said Schaab. “Jenn contacted us last season as Halter Media, was filming episodes for the TV series ‘Flat Out Foods’, and Jenn thought we’d be a good fit.
“I was apprehensive in the beginning to accept her invitation, but Jenn was so great and excited to share our story, that Darrel and I slowly agreed to do the interview.
“The children’s book was how I felt leading up to the interview.
“Plus, something I’m positive everyone, children or adults can relate to -- the feeling of trying to be someone you aren’t, only wanting to fit in.”
Schaab said writing the book also fit with what she was trained to do, educate.
“My background is in education, and I always tried to inspire my students to be themselves, and be proud of who they are,” she said.
“. . . I think my goal was to combine my love of teaching with my passion of growing food, but have a story that teaches something in a light and fun way.”
The book has been a creation of discovery for the author.
”I had no idea what to expect, but just knew I wanted to try,” she said. “If I had failed, at least I had the courage to do it.
“So the book exceeded all my expectations and my publisher Julianne (with FriesenPress), was amazing to work with. She made every step seem like a possible adventure.”
The reaction to the book has so far been amazing, said the author, starting with holding the first book.
“I can’t believe this is real,” offered Schaab.
Others have liked it too, with the author terming it “overwhelming, with positive remarks, which I am so grateful and deeply humbled.”
And new ideas are already percolating for more books.
“Anna the garlic farmer has many, many stories that she wants to share -- all true experiences,” said Schaab.
You can no longer count on social media to deliver your local news to you. Keep your news a touch away by bookmarking Yorkton This Week's homepage at this link.
Here's why you should bookmark your favourites.
Bookmark SASKTODAY.ca, Saskatchewan's home page, at this link.


text:
... I began to understand why people said of the lake there's no end to it, when of course, as I always thought, it was bounded by rocks. But there were rivers flowing in and flowing out, secret currents, six kinds of weather working on the surface and a hidden terrain underneath. Each wave washed in from somewhere unseen and washed right out again to go somewhere unknown...
~Louise Erdrich, The Plague of Doves
Spending a weekend at what we Midwesterners call "The Lake" can be most sublime, or just plain ridiculous. "The Lake" is a concept, a fictional conceit, a mass delusion. Wilderness trekkers aside, the Modern Idea of "The Lake" is a home away from home, in fact, just like home, except that instead of streets and parks, there is a body of water. "The Lake" used to be a humble cabin, with a rickety dock amidst the reeds, a place where Nature was unchallenged, visitors were few and respectful. Somewhere along the line the experience became another form of consumerism, of display, with noisy and smelly machines churning the aqueous mirror, shattering the silence and destroying the shoreline habitat. Not much sustenance for the mystic poet here: Walden be dammed.
Last weekend was not completely misspent, however, for I read the latest book from Louise Erdrich, who is by now some sort of patron saint of Minnesota-North Dakota literature. The Plague of Doves is her twelfth novel, a glorious mash of small town secrets and passion. All of her books are great- if you're interested in starting a relationship with a new author her novel Tracks would be a good place to begin but feel free to dive right in if you happen across any of these other titles:
The Beet Queen
The Bingo Palace
Tales of Burning Love
The Antelope Wife
The Last Report on the Miracles at Little No Horse
The Master Butchers Singing Club
The Painted Drum
The Crown of Columbus (with Michael Dorris)

domain: library


The So So Def 20th Anniversary concert at The Fox Theater in Atlanta definitely turned out to be much bigger than people expected. There were some obvious performers including Kris Kross, Bow Wow, Da Brat, Jagged Edge and more but the big surprise of the night was none other than Jay-Z. This was after JD had already pleased the crowd by bringing out Mariah, Usher, Ludacris and Usher.
He came out to perform ‘Money Ain’t A Thang’ and then passed on the mic to Young Jeezy who rocked his current hit ‘RIP’. But JD had more in store for the audience as he called Hov back to the stage to do ‘PSA’, ‘N***as In Paris’ and ‘Clique’. Watch Jay-Z, JD, Usher and Ludacris perform after the break. Historic night indeed and congratulations to the whole So So Def family.
Jay-Z ‘Money Ain’t A Thang’ & Young Jeezy ‘RIP’
‘PSA’, ‘N***as In Paris’ and ‘Clique’
Usher, Lil Jon and Ludacris
Footage Via Yardie


Safety should be the paramount concern for Lauderdale-by-the-Sea officials now that volunteer firefighters have been reinstated.
But the dispute over fire protection has been so nasty at times that it's hard to judge the switch from the Broward Sheriff's Office to the town's Volunteer Fire Department. Is it really the safest, most cost-effective option for LBTS? Or just a power play comeback for volunteer firefighters who were left unhappy when BSO terminated their contract in 2004?
The town's contract with BSO expired in October, and the town commission, dominated by volunteer firefighters, has opted not to renew it. Now that the Volunteer Fire Department has been reinstated, it makes no sense to continue down a divisive path by rehashing this debate.
Instead, all sides should work together to make the VFD as effective as possible, building greater trust and acceptance along the way.
Some residents worry that the VFD response time isn't expected to match BSO's, which in its final year reported an average time of 3 minutes and 56 seconds for 18 fire calls, according to a recent Sun Sentinel report. The VFD's contract allows a nine minute response, and during the first two weeks volunteer firefighters responded within four to seven minutes, said Fire Chief Robert Perkins.
The volunteer department should make every effort to close the gap with BSO's past performance. That would allay resident concerns, and defuse tensions raised over this debate.
The volunteers would do well, too, to adequately prepare to respond to a fire that could one day erupt at one of the town's condo towers, a major concern for residents. Another possibility would be to consider hiring a paid professional fire chief to head the volunteer department. Or even creating a citizens committee to keep lines of communication open between firefighters and residents.
The bruising battle is over. The town should support the VFD, and the VFD should work to maintain that trust.
BOTTOM LINE: Necessary to build trust, acceptance.


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Practicing ethics is not an easy job for everyone especially if people need to consider their own interests or the interest of the people around them. Taking egoism and utilitarianism in to account, a person must come up with a sound decision that will be based in his/her own principle (Moseley 2006).
Egoism Principle in Joelle’s Case
Following egoism principle for the case, Joelle has to keep his promise to Mr. Espinal and keep quiet about the company’s secret of dumping toxic waste in a nearby lake. As a senior student, Joelle is very lucky to have the opportunity to work in the chemical plant that is willing to keep Joelle as a regular employee and offer college financial support (Moseley 2006). Examining the situation, the chemical plant’s offer gives a lot of opportunity for Joelle to have a more stable college education and career after graduation.
In egoism, all persons act for their own interests (Moseley 2006). By keeping the chemical plant’s secret, Joelle is serving her own interest and the plant’s interests at the same time. Because Joelle is an employee in the chemical plant, Mr. Espinal has a hold on him and that is through the college assistance offer that Joelle might lose once she reveals the secret.
By staying loyal to Mr. Espinal, Joelle is able to ensure a bright future without worrying on financial needs and job problems. By doing a simple task of keeping quiet, Joelle is able to save a lot of money and be better than everyone else in the future.
The downside of keeping the secret is that, people living in the area will be subjected to the harmful effects of the chemicals like health problems and death in a worst situation.
Utility Principle in Joelle’s Case
If Joelle will follow the utility principle and let the authority know about the chemical’s plant’s unethical actions, she will be able to save herself and the thousands of people living in the area from the harmful effects of the chemicals (Willett 2009).
According to law, chemical plants are required to practice a safe way of dumping their waste to avoid chemical spillage that may cause harmful effects to humans, animals, plants and other living things. The effect of the chemicals might last for years depending on its toxicity level. Therefore, any violation of this rule will subject the chemical plant to legal actions, fines and closure (CHR 2000).
If Joelle will let the authorities know about Mr. Espinal’s company secrets, the chemical plant’s unlawful actions will be immediately addressed and the chemical plant will be prevented from further polluting the lake and affecting thousands of people especially the young ones. In addition, through Joelle’s mother, people from other areas and environmental organizations will be aware of the chemical plant’s unethical operations and will have the option to stop buying their products or request the retailers to stop selling the chemical plant’s products as a form of protest against them (Willett 2009).
The downside of Joelle’s decision of considering the interests of the majority is that Joelle will not be able to have the college assistant grant that is offered by the chemical plant. If the company closes, Joelle will lose her job, college financial assistance and future position in the chemical plant. In the worst situation, Joelle’s life might be at risk if the chemical plant will try to threaten her life to protect the chemical plant’s interests.
Joelle should have the courage to reveal the chemical plant’s secret to the authority so that appropriate legal actions can be done. Joelle might lose her job and financial grant but her dreams are still there and Joelle can still work her way to her success. Joelle is a good student and hardworking employee thus, through her efforts; Joelle will surely find another company that can help her. What is important is that Joelle will be able to protect the interests of many people and be able to save herself, her family and the thousands of people living in the area today and even in the future.
Commission on Human Rights. (2000). Adverse effects of the illicit movement and dumping of toxic and dangerous products and wastes on the enjoyment of human rights. Commission on Human Rights Resolution. Available at: http://www.unhchr.ch/Huridocda/Huridoca.nsf/TestFrame/50cb8807b242b2ce802568d6002fdf1b?Opendocument
Moseley, A. (2006). Egoism. The Internet Encyclopedia of Philosophy. Available at: http://www.iep.utm.edu/e/egoism.htm
Willett, M. (2009). The Utility Principle. Debate Unlimited. Available at: http://www.mwillett.org/Politics/utility.htm

domain: law


text:
Ancient of days! august Athena! where,
Where are thy men of might, thy grand in soul?
Gone – glimmering through the dream of things that were:
First in the race that led to Glory’s goal,
They won, and passed away – is this the whole?
A schoolboy’s tale, the wonder of an hour!
The warrior’s weapon and the sophist’s stole
Are sought in vain, and o’er each mouldering tower,
Dim with the mist of years, grey flits the shade of power.
- Lord Byron, Childe Harold’s Pilgrimage, Canto II (1812), Stanza 2.


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The cryptocurrency ecosystem faced significant challenges in 2022, majorly due to the collapse of Terra, which ticked off a market downturn. Even after a year passing since the network crash, the creator of Terra, Do Kwon, has been detained in Montenegro. Along with various charges in different jurisdictions, Montenegro has accused him specifically of document forgery.
In a recent hearing, both Kwon and Han Chang-Joon, Terra’s former chief financial officer, were ordered to pay up to 400,000 euros, about $437,240 each. Kwon mentioned that his wife is expected to make the payment. In addition, he admitted to owning an apartment unit in South Korea. However, when questioned by the judge in the presence of the media, Kwon declined to disclose further details regarding his assets.
More recently, the Seoul Southern District Court agreed to the prosecutors’ request to freeze 233.3 billion won in assets. This amounts to around $176 million, belonging to Kwon. Additionally, authorities have denied him access to his apartment unit in Seoul. His valuable possessions and monetary deposits have been seized. These measures have been taken as part of the ongoing legal proceedings against him.
Terra: Meanwhile, LUNC staking records new highs
A prominent member of the Terra Classic community, Rex Yeller Belly, informed that the staking of LUNC Terra Classic’s native token reached a new milestone. Currently, there are 970,351,935,248 tokens locked up in staking contracts, indicating a significant increase in staked coins.
The current staking ratio stands at 14.15%. Therefore, the LUNC community is eagerly awaiting the landmark of one trillion token-staked in the near future. The new all-time high in the amount of staked LUNC tokens is indicative of the optimistic sentiment prevailing among investors concerning the future outlook of the Terra ecosystem. However, LUNC was trading for $0.00008506 with a 6.72% daily drop.
Credit: Source link
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text:
Products on VitaPoint can be delivered to your home or alternative address in the UK. We also deliver to non-mainland UK addresses and certain remote locations (e.g. Scottish Isles, Isle of Man, Isle of Wight, Northern Ireland and the Scottish Highlands). Unfortunately we do not deliver to British Forces Post Office BFPO.
Standard Delivery within 2 to 3 working days
Next Day Delivery
Please be aware that parcels will not be delivered on the Bank holiday Monday and that you should receive your parcel on the Tuesday of that week for orders placed on the Friday and/or Saturday.
For UK and Northern Ireland deliveries, If no one is available to accept delivery of the parcel, the courier will do their best to leave the parcel in a secure location or as per your instructions when placing the order. If this isn't possible, the parcel will be taken back to the depot. In both cases, a card will be left informing you of the attempted delivery.
This is possible, but please remember to tick the box indicating that the billing address will be different when going through the checkout.
Please contact our Customer Service team at firstname.lastname@example.org if you have not received your order 4 days after dispatch of your order for further advice, in order for us to deal with your query you must contact us within 28 days of dispatch of your order.


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The Barclays Center yesterday gave a home-court advantage to Brooklyn voters.
That comes after Brooklyn Borough President Eric Adams and City Council Majority Leader Laurie Cumbo (D-Fort Greene, Clinton Hill, Downtown Brooklyn, Prospect Heights, Crown Heights), in partnership with Executive Director of the New York City Board of Elections Michael Ryan and BSE Global CEO John Abbamondi announced yesterday – on National Poll Worker Recruitment Day – that the stadium home of the Brooklyn Nets will be utilized as a polling place for the general election in November.
The massive site can reportedly host thousands of voters for early voting from October 24 to November 1, and on Election Day, November 3, to allow compliance with the Centers for Disease Control (CDC) safety guidelines indoors and to stave off any complications that may arise from other sites, mail-in and absentee ballot voting.
“Voting rights are under attack in this country,” said Cumbo at a press conference held in the stadium’s central outside plaza. “As a global pandemic threatens our ability to safely access the polls, and we have executive leadership whose continued attempts to suppress voters threaten the future of our democracy, it is up to local governments and leadership to innovate and ensure equal voting opportunities. Casting your ballot in person should be as simple as hopping on a train.”
The elected officials also made a plea for more poll workers, and hoped to rally people to become paid workers for the general election.
Ryan said that it’s always a difficult challenge to staff polls and establish sites for administrators nationally. He said the assistance from Barclays will “boost” already stretched polling managers who have worked tirelessly during the pandemic.
“I am so pleased that Barclays Center has stepped up in such a crucial election,” said Ryan. “The more options voters have, the smoother and safer the voting process becomes, especially in what is still a uniquely trying time for the city.”
BSE Global, the parent company for the Brooklyn Nets and Barclays Center, said it will be providing poll workers opportunities for its employees in response to the staffing shortage. Employees are offered a full paid day off to staff a polling site, said Abbamondi.
“We’re proud of the incredible effort, led in fact by our own NBA players, that we’ve been able to make across the NBA to have our arenas be voting centers throughout the country,” said Abbamondi. “Our community as we all know has been hit particularly hard by COVID-19. And I’d say, perhaps among it’s less important aspects, has been the shuttering of this building for the past five months or so. COVID-19 has also given us a chance to serve our community in ways that hadn’t been possible before.”
Throughout the COVID-19 and racial injustice crises and protests in the city, state, and nation, Barclays’ plaza has been a nerve center for numerous activists and demonstrations.
“This is a very significant moment for all of us as we navigate the challenges due to COVID-19 and how do we ensure a fair election process,” said Adams, recounting the packed plaza of protesters and dealing with COVID. “America is unique in the transformation of power. We use the ballot and not bullets. We use our opportunity to be creative and continue to reform and modify our system as we ensure who’s going to be the leader of this great country.”
Adams also remarked that it would be a good idea to convert the arena and other unconventional spaces into viable options for school reopenings. His statement on this issue came on the same day the city announced a two-week delay of in-person school reopenings among threats of a teachers’ union strike.
“I think we have to look at all the spaces that are available that are not being utilized now. Any creative way that we can make that happen, Barclays, movie theaters,” said Adams. “One thing we have to be clear on, our children did not receive an education at the end of the school year. We have to be honest about it, let’s stop pretending as though every child was educated, and I’m concerned that we didn’t spend the entire summer being properly prepared, so wherever spaces are available for use I think we should use them. We must make sure our children receive a quality education. This can’t be a continuation of failure.”
For more information on becoming a poll worker go to nyc.electiondayworker.com
For general how to register and vote info go to elections.ny.gov


text: "New York has a rich history of producing some iconic companies, from the likes of FR to B.Unique, they’ve left an impressionable mark in the rollerblading world. Jordan Baez, a New York native of the Lower East Side and blader of over 10 years, is looking to do the same. Baez’s first introduction to skating was as a young child. “When I was a kid in elementary school I used to hang out with these kids (that skated).”, he explains. ” I never was a skater; I was always playing basketball. But these were my close friends and they had blades, and they convinced me (to get into it), so I got blades and at that time people were so crazy I’d never thought I could keep up, so I hung em up.” Although initially defeated by self-doubt, Jordan would rekindle his relationship with the sport a few years later. “At the age of 16 I picked ’em back up and never let em go.” From there, his passion for the sport intensified, forming relationships with a handful of NYC skaters that led him to begin his own crew. Originally beginning in 2014-2015 under the moniker ‘New York Money Team,’ the idea developed into what is now Ghetto Community, a group of like minded individuals looking to push not only the coverage of the New York blade scene, but expand beyond that to inspire and support other regions of the blading world."

domain: artistic


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Global music icons Lea Salonga and Apl.de.Ap are leading fellow Filipino stars participating in the #StopAllHate #ShareLove music video as part of Asia Society’s global campaign to end violence against Asians in the United States and around the world.
Broadway royalty Lea Salonga and Black Eyed Peas’ rapper Apl.de.ap lead the star-studded cast of singers performed a new rendition of the Rodgers and Hammerstein song about bigotry and intolerance of other races, “You’ve Got To Be Carefully Taught”, as a response to hate crimes targeting people of Asian descent in the wake of the coronavirus outbreak.
The song originally composed for the 1950s hit musical “South Pacific” was updated with new lyrics to reflect a positive message and show the world that people can learn to love rather than hate.
Other featured artists in the music video released on June 21, 2021, include Gary Valenciano, Martin Nievera, Daniel Padilla, Jed Madela, Jaya, Cris Villonco, Moira Dela Torre, and Sam Concepcion. Mon Faustino provided the musical and vocal arrangement.
Aside from the Filipino singers, Asia Society’s #StopAsianHate campaign also featured broadcasters Korina Sanchez and Karen Davila who shared messages of hope to Filipino and Asian American communities.
Apl.de.Ap and other Filipino American stars are using their voices to call for a stop to anti-Asian discrimination and hate crimes in the United States.
NBA superstar Jordan Clarkson recently stepped in to restore a Filipino and Asian fusion food truck in Utah after it was spray-painted with anti-Asian and racist messages of hate.
SEND CHEERS in the comments below to Filipino music icons who have joined forces in the #StopAllHate #ShareLove music video for Asia Society’s global campaign to end violence against Asians and WATCH the music video here!
Good News Pilipinas is celebrating its 15th Anniversary in 2021 by giving away prizes! Subscribe to our Good News Pilipinas! TV YouTube channel and enter the raffle by sending us an email to firstname.lastname@example.org


text:
- Did you mean
- wooster ag facilities consisted research farms
Good Agricultural Practices (GAPs), Gallia County
industry stakeholders on Good Agricultural Practices (GAPs) and on-farm food safety. Wednesday, August 13, ...
NC State's "Pack 'N Cool" Provides Farmers with Mobile Refrigeration Solution
farmers markets or as they're harvested in farm fields. The Pack 'N Cool is the program's ...
How to Use Quicken for Your Farm Recordkeeping
Click below to download the entire Quicken Manual: Click below to download individual chapters of the Quicken Manual: ...
#TrueLeaders: 4-H Week
to check on plants and help with the garden. The garden was also a stop on the county’s Urban Farm ...
Ohio 4-H Horse Program Recognition Banquet
Location: Bob Evans Memorial Auditorium, The Nationwide & Ohio Farm Bureau 4-H Center. ...
4-H Volunteer Conference
The 2013 4-H Volunteer Conference and Bob Evans Farms Recognition Luncheon will take place at the ...
Common Uses on the Farm
AgrAbility can visit your farm to help determine assistive technology solutions through on-site assessments ...
Good Agricultural Practices (GAPs), Williams County
stakeholders on good agricultural practices and food safety for the produce farm. 6:00pm-9:00pm February 20, ...
Good Agricultural Practices (GAPs), Lucas County
stakeholders on good agricultural practices and food safety for the produce farm. 1:00pm-4:00pm February 20, ...
Ohio No-Till Day
am- 3:30 pm Location: Bret McGraf Farm (Seneca County), 7838 State Route 587, McCutchenville OH 44844 ...

domain: agronomy


text:
Angel Food Cake with whipped cream and blueberries. Catch the symbolism there?
We made candle holders out of clay pots. The girls decoupaged pictures of the Annunciation onto the little pots then decorated the rest with markers. They turned out cute and we've been lighting for our morning rosary.
I know the girls don't look thrilled but they really did enjoy this craft!


Request for Bids
Town of Sharon, VT
The Town of Sharon is seeking proposals from qualified contractors to perform grounds maintenance on Town properties in Sharon Village. The contract period is May 1, 2017 – November 30, 2020. Work activities include spring and fall cleanup, mowing and lawn maintenance, planting, cultivation, and maintenance of some garden beds.
Sealed bids due 3pm Monday April 24 , 2017 to Sharon Town Offices, 69 VT Rte 132, P.O. Box 250, Sharon, VT 05065. Please do not fax or email your bid. Complete bid specs and bid forms may be downloaded from www.sharonvt.net. Info: 802-763-8268 #4


e-Petitioner for English Local Authorities
E-petitioning was implemented and piloted by the Royal Borough of Kingston upon Thames who led the project, and Bristol City Council. The development of e-petitioning in the National Project stemmed from the experience of the Scottish Parliament and both Councils acknowledge how their use of the system has been derived from the Scottish Parliament’s guidelines. The project had two main aims:
- to outline requirements for the design and management of e-petitioning processes that can stimulate active citizen participation in local communities;
- to trace the path of e-petitions through the committees of the Councils and assess whether or not, and, if so, how input by the public via e-petitioning impacts on decision-making at different levels.
The ITC worked alongside the Councils’ e-Democracy project managers to localise the e-Petitioner tool and embed it in their processes for handling petitions, while ensuring it remained sufficiently generic to be easily adapted to the needs of other Councils. In Kingston this work was coordinated through the IT Department, and in Bristol through the Corporate Consultation team. As well as deploying the system and developing procedures to handle e-petitions, the Councils’ role included promoting the system internally (to Council Officers/Councillors) and externally (to members of the public).
The first task in establishing the e-Petitioning System within a Local Authority is to formally define a petitions process that is suitable to their context. In Kingston, developing the e-petitioning process entailed a need to publish guidelines for the first time, and to put in place a mechanism for managing new e-petitions ie. contacting the principle petitioner and the key council officers responsible for the matter raised, as well as updating the site and publishing the Council’s formal response to each petition. The addition of a new ‘channel’ for petitioning and the associated need to guide website visitors on how they might use it, established the case for publishing Guidelines on petitioning in general.
The main effort in transferring the system lay in meeting the need for easy to use administration functions, and in providing a more modular architecture suited to the need for the software to be tailored to the varying needs of local authorities. The Scottish Parliament e-Petitioner System is maintained by ITC as a ‘managed service’, an arrangement that could not meet the needs of the National Project tools to be sustainable beyond the life of the project. Kingston and Bristol required facilities for their own officers to administer their respective systems.
At the end of the pilot period (17 March 2005) there were 7 e-Petitions for Kingston, and 9 paper petitions were presented to the Council in the same period. In Bristol there were 9 e-petitions and 22 on paper. The total number of e-petition signatures was 173 in Kingston and 890 in Bristol. Citizens, Officers and Members who took part in the evaluation were almost unanimously in favour of e-petitioning. It has enjoyed strong support from Councillors in both Kingston and Bristol, particularly Kingston, and from the departments who are directly involved in the day-to-day servicing of representative government. The issues raised through e-petitioning are unarguably issues that are important to citizens, and are evidently addressed through local authority decision-making. E-petitions were raised on, for example, road crossings, telecoms masts, and Post Office closures.
The website and its associated guidelines on petitioning makes both the process and the petition outcomes more visible. The added visibility applies to paper as well as e-petitions, since paper petitions that are presented at Council meetings are also listed on the e-Petitioner page. The evaluation states:
“The evaluation found much had been accomplished in both Councils. Over the one year project lifetime staff were recruited, the supplier contracted, e-Petitioner implemented, working practices and processes examined and the tool launched to be used by the public. E-Petitioner was used by hundreds of citizens in each Council area, and showed early signs of impacting on decision-making.”
The success of the ePetitioner system is perhaps best demonstrated by the fact that both councils are committed to continue to use the system after the end of the pilot funding. Bristol worked with ITC on amendments and having the system hosted on the ITC server until January 2008.
Both local authorities recorded their experiences of using online petitioning, the resulting documents providing valuable insights to other councils who might be considering adopting such a facility.
- The ICELE Special Supplement on ePetitions including a section by the Royal Borough of Kingston.
- ePetitioning: A viewpoint from Bristol City Council.
- Bristol City’s experience of ePetitions as regarded within the broader context of eConsultation methods.
- “Effective petitioning – the internet way”; a guide to ePetitioning for democratic institutions.
- “E-Petitioning: Online petitioning services (ppt)”; a PowerPoint presentation produced by Bristol City Council as part of the ODPM ‘Local e-Democracy’ project.
- “Lessons learned from the day to day management of an e-petitions website”; a PowerPoint presentation by Mike Brewin of the Bristol City Council Consultation Team.
Feedback has been largely positive, as the following quotes from the main actors in the petition process demonstrate (ICELE: ePetitions - the benefits):
If you are in full-time work, and if you have a small child, ePetitioning makes it easier to get involved in the local community. It gives a voice to those in such a position, who would otherwise be silent on local politics -Maria Samuels, principal petitioner
ePetitions can provide another way for people to raise matters with the council if they want to...it's a matter of extending choice...I'd expect developments like this to become more and more important over the next few years -Stephen McNamara, Head of Legal Services, Bristol City Council
One of the roles of the councillor is to provide help, and mine is an ethnically diverse ward and there are certain groups and organisations - ethnic and religious - that find it difficult to get accurate, adequate representation. And as they get access to technology, this presents a chance to give them that representation - it is much more inclusive. - Councillor Sue O’Donnell
As an illustration of how effective an e-petition can be, consider the one raised by a Bristol resident in response to a pedestrian fatality in February 2007. His e-petition prompted the Council to improve safety along the stretch of road concerned. The petitioner was encouraged by this response, saying: I’m pleased on both fronts – the e-petition has been listened to and we’ve made improvements to the safety of the area (From BBC news, 2007)
From these comments, it appears that the early promise detected by the evaluation is being sustained.
Links on this website
Each publication is linked to its reference
- Evaluating how eParticipation changes local democracy
- e-Petitioning: Enabling Ground-up Participation
- E-Methods for Public Engagement
- eDemocracy from the Top Down
- e-Petitioning in Kingston and Bristol
- Government Computing interview: Peter Cruickshank emphasises the need for human support for e-petitioners, 02/02/2011
- Presentation to German Parliament's Petitions Committee, 02/02/2011
- Kosovan Parliament's visit, 12/05/2010
- Bavarian Parliament's Petitions committee visit, 11/05/2010
- ITC Celebrates 10th Anniversary, 30/10/2009
- ITC give evidence to House of Commons Procedure Committee, 30/01/2008
- Bill Gates and George Reid praise Scottish Parliament's innovative use of technolgy, 15/02/2007
- This is Bristol - e-Petition case studies, 19/01/2007
- Scots' online petitions winning the German vote, 13/11/2006
- ITC's e-Petitioner: finalist in eEurope and the UK, 28/11/2005


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The drugs are a part of detricyclic antidepressants group.This group of drugs has a low therapeutic index and many side effects, even at therapeutic levels, therefore its dosage should be maximum individualized. The drugs are secondary or tertiary amines. Tertiary amines are metabolized by several CYP450 whereas secondary ones are metabolized by CYP2D6 .
FDA warns on the drug label for nortriptyline of the difference in the blood concentrations of the drug depending on the metabolizing phenotype concerning CYP2D6, which is highlighted in the following except:“The biochemical activity of the drug metabolizing isozyme cytochrome P450 2D6 (debrisoquin hidroxylase) is reduced in a subset of the Caucasian population (about 7% – 10% of Caucasians are so called “poor metabolizers” … “Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of the drug metabolized by P450 2D6, the increase in plasma concentration can be small, or quite large (8 fold increase in the AUC of the TCA).”
Both of them, in practice, have CYP2D6 as the main metabolizing enzyme. Indeed, amitriptyline (terciary amine) is metabolized primarily through CYP2D6, and to a lesser extent through other CYP enzymes (2C9, 2C19, 3A4) which transforms it into nortriptyline, which is later metabolized mainly through CYP2D6. Nortriptyline (a secondary amine) is metabolized directly through CYP2D6 as the main pathway. The hydroxilated derivates generated by CYP2D6 have some pharmacologic action, although somewhat lower than the parent drug and are eliminated in urine a glucuronides, by means of the UGT (Uridin-Glucuoronyl-Transferase) enzymes in the phase II metabolism.
Both compounds act as moderate CYP2D6 competitive inhibitors. There are big differences in the plasma concentrations obtained by the different phenotypes.
Other factors to be considered
In case of patients who have a PM phenotype for CYP2D6, there have been reports of adverse effects consisting of dizziness and sedation. However, adverse effects can also be found in patients with an EM phenotype who take drugs that are competitive (or other kind) CYP2D6 inhibitors, which can be frequent because this CYP enzyme has low capacity (only 2% of all the CYP content) and there are lots of drugs whose phase I metabolism depends on CYP2D6: 26% of them. Also notice that in patients with the UM phenotype, the standard dose may not produce any therapeutic effect. The solution may be increasing the dose or using an antidepressant drug which is not metabolized through CYP2D6.
When amitriptyline is prescribed,it is convenientknow the phenotype of CYP2D6 and CYP2C19to titrate the dose correctly because it is the enzyme defining the rate of metabolism. It would be even simpler to administer nortriptyline to people who are PM for CYP2C19 as 80% of its metabolism is through CYP2D6. In people who are poor or ultrarrapid metabolizers for CYP2D6 and/or CYP2C19 consider alternative drugs that do not use this metabolic pathway, such as bupropion, citalopram or escitalopram or adjust the dose according to the genotype.In PMs for CYP2D6 or CYP2C19 the doses should be reduced by 30-50%. In IMs for CYP2D6 the conventional dose might be safe, but it would be prudent to reduce it by 20-25%, while in the case of CYP2C19 the intermediate metabolizer phenotype does not appear to be relevant and there is not necessary to take any action.In the case of an UM phenotype for any of the enzymes it is highly encouraged to use another drug. Increasing the dose might allow reaching the desired levels of amitriptyline and nortriptyline, but the accumulation of inactive metabolites might be cardiotoxic despite the lack of therapeutic action.In the case of variant genotypes for both genes, the scientific literature has scarce data due to the low frequency of these combinations. Below there is a transcription of the reccomendations of the Clinical Pharmacogenetics Implementation Consortium. (Hicks JK et al; 2013).
- Hicks J.K. et al. (2013). Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants. Clin Pharmacol Ther. 93(5):402-8.
- Thieme D. et al. Correlation of inter-individual variations of amitriptyline metabolism examined in hairs with CYP2C19 and CYP2D6 polymorphisms. Int. J. Legal. Med. 122(2):149-55. Epub 2007 Nov 9.
- De Leon J et al (2006). Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19. Psychosomatics; 47(1):75-85.
- Gardiner SJ, Begg EJ. (2006). Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacol Rev. 58(3):521-90.
- Steimer W et al (2005). Amitriptyline or not, that is the question: pharmacogenetic testing of CYP2D6 and CYP2C19 identifies patients with low or high risk for side effects in amitriptyline therapy. Clin Chem. 51(2):376-85.
- Kirchheiner J. et al. (2004). Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response. Mol Psychiatry; 9(5):442-73.
- Matthew V. Rudorfer and William Z. Potter. (1999). Metabolism of Tricyclic Antidepressants. Cellular and Molecular Neurobiology; 19 (3), 373-409.
Juan Sabater-TobellaDoctor of PharmacyEuropean Specialist in Clinical ChemistryAnd Laboratory Medicine (EC4)
Last modified: Sep 6, 2017 @ 09:59 am

domain: health


We offer pet supplies in our store which is conveniently positioned in the identical constructing as the apply. West Pawtal Pet Supplies has an amazing number of cat toys at very reasonable prices, higher than I’ve seen at much bigger chain shops. At the top of your Opera window, near the net deal with, it’s best to see a grey location pin. And with dog food, cat food and fowl seed, we provide you with plenty of choices for keeping your creatures well-fed. Collars and leashes are a necessity until a dog has its own space to run in. As with cats, ID tags are must-have objects.
Founded in 1988 and headquartered in Livonia, Michigan, PSP is a leading franchisor and operator of pet-specialty stores that present a buyer-centric purchasing experience in smaller shops which have a neighborhood feel. Earlier than you feel overwhelmed, rest straightforward knowing that almost all … Read the rest
The IWT Nationwide Reptile Survey goals to survey the distribution of Ireland’s two wild species of terrestrial reptile – the native common lizard (Zootoca vivipara) and the introduced sluggish worm (Anguis fragilis). Candidates who wish to import reptiles into the ACT should be capable to present details of the relevant State or Territory authority underneath which the reptiles were beforehand held and the authority to export. We are calling for once-off sightings from the public as well as recruiting volunteers to head out reptile surveying as citizen scientist – utilizing easy and efficient survey methods to look for lizards and gradual worm of their local space.
Most reptiles are diurnal animals. Native reptiles are protected by legislation so if you wish to hold a native reptile as a pet you may need a biodiversity conservation licence granted beneath the Biodiversity Conservation Act 2016 from the Office of Atmosphere and Heritage … Read the rest
A category of cold-blooded vertebrates that features turtles, lizards , snakes, alligators and crocodile. From the lethal black mamba to the African rock python, Reptile Encounters at Backyard Route Recreation Lodge is residence to twenty-eight totally different snake species, Nile crocodiles, tortoises and terrapins. It’s against the legislation (Biodiversity Conservation Act 2016) to take native reptiles from the wild or launch unwanted ones. 39 It was a small, lizard-like animal, about 20 to 30 centimetres (7.9 to 11.eight in) long, with quite a few sharp enamel indicating an insectivorous eating regimen.
This fashion you may discover our zoo knowing that our reptiles are beloved and handled with utmost respect. Left untreated, dental illness isn’t just bad to your pet’s teeth; it may actually injury inner organs, together with the heart, liver and kidneys. You may discover extra dietary solutions and merchandise in our reptile well being and wellbeing range , … Read the rest
Little Ray’s Nature Centres is Canada’s leader in providing world-class, interactive, interpretive animal schooling reveals and programming for museums, conservatories, zoos, nature parks, and botanical gardens. Tuatara once lived all through the mainland of New Zealand but have survived in the wild only on 32 offshore islands. Snakes, lizards, reptiles, turtles and extra, oh my. A brand new kind of reptile zoo has simply opened its doorways on Van Dyke Avenue in Utica and slithered by means of a comfortable opening over the weekend. They embrace crocodiles, snakes, lizards, turtles, and tor- toises.
1 particular person of each reptile or amphibian from Record B. Only 1 particular person of each species could have been taken from the wild, besides no Wood Turtles, Spotted Turtles, or Diamond-backed Terrapins may be taken from the wild. At varying times all through the day, animal care employees introduce visitors to one of the Zoo’s … Read the rest
Forging proactive partnerships to preserve amphibians, reptiles, and the places they stay. Applicants who wish to import reptiles into the ACT should be capable to provide details of the related State or Territory authority beneath which the reptiles had been previously held and the authority to export. We are calling for once-off sightings from the public as well as recruiting volunteers to head out reptile surveying as citizen scientist – using easy and effective survey methods to search for lizards and sluggish worm in their local space.
The Reptile Discovery Heart celebrates the diversity, magnificence and distinctive variations of greater than 70 reptiles and amphibians. The Conservation In Motion Lab permits guests to interact with ZSL zookeepers and scientists who’re conducting research for Mallorcan midwife toads, Sardinian brook salamanders and Lake Oku frogs to research the consequences of the lethal chytridiomycosis, a fungal pathogen which is driving amphibian population declines … Read the rest
Forging proactive partnerships to preserve amphibians, reptiles, and the locations they stay. 1 individual of every reptile or amphibian from Checklist B. Only one individual of each species could have been taken from the wild, except no Wood Turtles, Spotted Turtles, or Diamond-backed Terrapins may be taken from the wild. At varying occasions throughout the day, animal care workers introduce guests to one of the Zoo’s reptiles and amphibians, together with: Aldabra tortoises, blue-tongued skink, leopard gecko, European glass lizard, corn snake, pine snake, Everglades rat snake and black-headed python.
An amazing variety of reptiles are kept as pets. A staple of our business is selling wildlife conservation, environmental consciousness, and schooling in regards to the animals we share the planet with. Unlike among the Zoo’s different animals, the inhabitants of the Reptile Discovery Center will not be found exterior in the course of the wintertime. Captive animals play an … Read the rest
Crocosaurus Cove presents the World’s largest display of Australian Reptiles, with over 70 species of reptiles on display. This is making reptiles the largest vertebrate group after fish (~25,000 species) and birds (~10,000 species), and considerably larger than mammals (~5,000 species) or amphibians (~6,000 species). Reptile Gardens is a premier South Dakota vacation spot that homes a number of the world’s deadliest snakes and is in the Guinness E book of World Data because the World’s Largest Reptile Zoo.
forty three Probably the greatest known early stem-reptiles is Mesosaurus , a genus from the early Permian that had returned to water, feeding on fish. 2.7 All licences issued below the Nature Conservation Act 1980 for actions involving reptiles shall be topic to situations set by the Conservator of Flora and Fauna. A permit could also be issued to own, breed, sell, supply for sale, commerce or barter reptiles or amphibians … Read the rest
Little Ray’s Nature Centres is Canada’s chief in offering world-class, interactive, interpretive animal training exhibits and programming for museums, conservatories, zoos, nature parks, and botanical gardens. Currently, suitably skilled members of the ACT Herpetological Association are permitted to take regionally occurring, non venomous reptiles from the wild for the purpose of study at Association meetings. And about a hundred and fifty other species of alligators, crocodiles, lizards, snakes, turtles, and tortoises. 5.1 Such animals embody migratory animals which can be topic to a Commonwealth conference, treaty or settlement, and species vulnerable to or threatened with extinction.
Some scales are very difficult to see as found on geckos, whereas other reptiles have modified scales that create a suit of armour or plating as seen in turtles. Reptilian pores and skin is covered in a horny epidermis , making it watertight and enabling reptiles to live on dry land, in contrast to … Read the rest
The IWT Nationwide Reptile Survey goals to survey the distribution of Eire’s two wild species of terrestrial reptile – the native frequent lizard (Zootoca vivipara) and the introduced gradual worm (Anguis fragilis). four.2 Species of reptiles that may be stored for educational functions embrace hobbyist species; locally occurring, non venomous species under no conservation menace; and species generally stored in captivity for educational or display purposes. Taking animals from the wild, or even your backyard, can cause native extinctions. Don’t catch wild reptiles or amphibians and maintain them as pets.
We stock specialist meals for bearded dragons, turtles and different reptiles in addition to supplements that may be added to your reptile’s meals to verify your pets are getting a balanced weight-reduction plan. We are properly stocked with a diverse selection ofÂ allÂ your reptile habitat and vivarium wants including unique hardwoods: mopani, java, drift wooden, ghost wood,twisty vines, tree … Read the rest
A category of chilly-blooded vertebrates that includes turtles, lizards , snakes, alligators and crocodile. A1: No. The street is closed to capture of reptiles and amphibians, as well as different wild animals and birds. A6: No. It’s a violation to use a synthetic mild from a motorized vehicle in locating, capturing or making an attempt to seize reptiles and amphibians on the shoulder of a street or on the unpaved space of a public right-of-way. The collection of snakes contains most local species one would encounter in South Africa as well as some unique species.
That means that we’ve been recognized for our excessive standards of animals welfare and contemplate our zoo a humane company for animal care, conservation, science, and training. These pet homeowners should keep a legitimate reptile of concern license for these animals. Our expertise, mixed with a true appreciation for these distinctive pets, allows us to … Read the rest


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Lottery is a form of gambling where you have the chance to win large sums of money. It is often run by governments to fund public projects or social programs. It can also be used as a form of charity. However, there are some drawbacks to lottery playing that you should be aware of before you play.
A lottery is a game of chance in which numbers are drawn at random to determine a winner. Depending on the type of lottery, the winnings can range from a few dollars to millions of dollars. The winnings are usually paid out in a lump sum, but some states allow players to receive payments over time. In addition, many lottery games are played online. There are several advantages to online lotteries, including the convenience and ease of entry.
Despite the widespread popularity of the lottery, there are many reasons why you should not gamble. For starters, the odds of winning are very low. In fact, only a very small percentage of people win the lottery. And if you do happen to be one of the lucky few, it will be a very brief period of happiness before your luck runs out.
Another reason why you should not gamble is that it can be addictive. Some studies have shown that the brain’s reward center is affected by gambling, which can lead to addiction and compulsive behavior. It is important to recognize this early on, as it can be difficult to overcome. Fortunately, there are some steps you can take to help prevent this from happening.
The main reason why people play the lottery is that it gives them the chance to win a large amount of money. This is why the lottery is so popular, and there are many different types of lottery games that can be played. There are even online versions of the game that allow you to play from the comfort of your own home.
Aside from the cash prizes, there are other benefits to playing the lottery. For example, it can give you a sense of community and can be a fun way to spend your spare time. Moreover, it can provide you with an adrenaline rush as you wait for the results.
Regardless of whether you’re a beginner or a professional, there are some things that every lottery player should know. In order to maximize your chances of winning, it’s a good idea to study the game carefully. Start by looking at the digits on the outside of the ticket and count how many times each number repeats. Then, look at the inside numbers and mark each one that appears only once (known as a singleton). A group of singletons typically signals a winning card 60-90% of the time.
If you’re a fan of sports, you may be familiar with the NBA draft lottery. This is a method of selecting the top 14 teams in the NBA. While it isn’t as popular as the regular season draft, it is still a great way to determine who will get first pick in the next draft.

domain: game


The US Supreme Court decision to overturn the landmark 1973 “Roe v Wade” decision that enshrined a right to abortion is the culmination of decades of peaceful but persistent advocacy by pro-life advocates.
As is the case in Australia, US States will now have the responsibility of regulating the practice of terminating babies in the womb.
The Australian Christian Lobby’s (ACL) National Director for Politics, Wendy Francis said,
“With the first photo of a wanted baby now an ultrasound image shared online, there is a clearer understanding of the humanity of the unborn. This has raised up a new, young, pro-life generation.”
In direct contrast to those who defend Australia’s brutal abortion to birth laws by claiming it is only a health issue, US Justice, Samuel Alito, stated, “Abortion presents a profound moral issue.”
Commenting on pro-life issues currently before the Australian federal parliament, Wendy Francis said,
“There are two areas that our federal parliament should immediately attend to:
- Hundreds of viable babies have been born alive over the past decade following an abortion, and left to die with no medical attention. This is barbaric and must end.
- The practice of sex-selection abortion is on the rise in Australia. Our Federal government must ensure this discriminatory practice is not funded by Medicare.
“It is our hope that this historical decision will impact Australian law in these ways.”
The ACL will continue to support, and build on, the pro-life movement in Australia.
Because every life matters.


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Dhaka, Bangladesh (BBN)– The body of Jahangir Alam, executive director of Bangladesh Bank (BB), who died of cardiac arrest in Istanbul, Turkey on Thursday, will arrive in the capital Dhaka Saturday morning.
“A Turkish flight carrying his body took off from Istanbul this (Friday) evening. The body is scheduled to arrive in the morning”, BB general manager AFM Asaduzzaman told BBN in Dhaka Friday night.
His first namaj-e-janaza will be held at his Minto Road residence at 9:30am while the second one will be held at Jatrabari at 11am on the day, he added.
The body will be kept on the central bank headquarters premises for few moments and another janaza will be held there at 10:30am on Sunday.
He will be buried at his village in Comilla.
Jahangir, who died at the age of 56, went to Istanbul to attend a meeting of Islamic Financial Services Board on Sunday.
BBN/SSR/AD-18May12-10:54 pm (BST)


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By Robin Roberts
"Regardless of ways a lot funds you could have, your race, the place you reside, what faith you persist with, you're going via whatever. otherwise you have already got otherwise you will. As momma continually acknowledged, "Everybody's obtained something."
So starts loved reliable Morning the United States anchor Robin Roberts's new memoir during which she recounts the brilliant trip that is been her existence to this point, and the teachings she's realized alongside the way in which. With grace, center, and humor, she writes approximately overcoming breast melanoma simply to profit 5 years later that she is going to desire a bone marrow transplant to wrestle a unprecedented blood affliction, the grief and heartbreak she suffered whilst her mom gave up the ghost, her victorious go back to GMA after her clinical depart, and the large aid and love of her friends and family that observed her via her tricky instances.
Following her mother's suggestion to "make your mess your message," Robin taught a kingdom of audience that whereas it really is precise that we have now all obtained whatever -- a scientific situation to stand, getting older mom and dad to take care of, heartbreak in all its many varieties --- we have additionally all bought whatever to provide: desire, encouragement, a life-saving transplant or a spirit-saving embody. As Robin has realized, and what readers of her awesome tale will come to think to boot, it is all approximately religion, friends and family. And checking out that you're superior, a lot more advantageous, than you think that.
Read or Download Everybody's got something PDF
Best cancer books
“I have breast melanoma. ” [/b]When sturdy Morning the United States anchor Amy Robach published her stunning analysis on reside tv in November 2013, the professional information reporter launched into the main tricky and illuminating trip of her existence. during this intimate memoir she retraces the 12 months following her declaration and speaks candidly, for the 1st time, approximately how her disorder affected her kin existence and her marriage, tapped into her private fears and strengths, and reworked her in methods she by no means can have imagined.
purely weeks past, in September 2013, ABC manufacturers requested Robach to get an on-air mammogram to focus on Breast melanoma expertise Month. Her first intuition was once to claim no—there used to be no historical past of melanoma in her kinfolk, she used to be purely 40 years outdated, and she or he felt unusual drawing recognition to herself whilst she had no own connection to the problem. (She’d been aspiring to get her first mammogram that yr yet had very easily “lost” the prescription. ) Her colleague Robin Roberts, herself a melanoma survivor, confident her to do it with one easy sentence: “I can pretty well warrantly it is going to shop a lifestyles. ”
To Robach’s shock, the existence she stored used to be her personal: exams published malignant tumors in her breast, and she or he instantly underwent a bilateral mastectomy, via six months of chemotherapy treatments.
larger is greater than a narrative of affliction and restoration. Robach recounts the day she and her husband, Andrew Shue, bought the poor information; the trouble of telling her younger daughters, and the demanding situations of continuing the standard tasks of parenting, nurturing a fledgling moment marriage, and coping with a public occupation. She lays naked the emotional toll of her event and mines her previous for the numerous moments that gave her the resilience to stand every day. and he or she describes the marvelous help community that lifted her whilst she hit bottom.
With honesty, humility, and humor, Robach connects deeply with girls similar to her who've struggled with any form of surprising adversity. extra vital, she stocks beneficial knowledge in regards to the strength of the human spirit to suffer the worst—and locate the right way to better.
Advance compliment for greater
“By selflessly sharing the excellent tale of her unforeseen trip with breast melanoma, Amy has given numerous others wish. higher is the right identify for her appealing ebook. Sitting subsequent to her each morning at GMA, I’m blessed to adventure how my expensive colleague and pal makes every little thing and everybody larger. ”—Robin Roberts, co-anchor of fine Morning America
“Amy is hard as nails and tenderhearted. the correct mix, no? i've got enjoyed her for years, yet by no means greater than whilst I watched her beat melanoma with such energy and style. Her ebook is stuffed with wish and healing—for Amy, and for we all. ”—Hoda Kotb, co-host of this present day
“[Robach’s] attractive new booklet, higher, is an exploration of her conflict with breast melanoma. What i admire approximately it really is that she by no means claims to be fearless; she was once petrified. . . . great inspiring stuff, the type we want far more of generally. ”—Meredith Rollins, editor in leader, Redbook
“With the superb heritage to Robach’s discovery of her illness, plus her inspirational tenacity in the course of her occupation, readers will most likely by no means leave out their annual mammogram back. For all sufferer health and wellbeing collections. ”—Library magazine
Chemotherapy for-cancer is in a country of evolution. simply because a few cancers can now be cured with chemotherapy as a novel modality, this remedy can now not be seen as easily a palliative contribution. Chemotherapy has assumed an enormous function as an adjuvant to different modalities, together with either surgical procedure and radiation remedy.
The records are sobering: over 200,000 males within the usa are clinically determined with prostate melanoma each year. With this prognosis, males are anticipated to psychologically wrestle the concern, useful matters, and the emotional and actual alterations in the course of an immensely making an attempt time. tips on how to support? In coping with Prostate melanoma: A consultant for residing greater, Dr.
- Cancer Immunotherapy at the Crossroads: How Tumors Evade Immunity and What Can Be Done (Current Clinical Oncology)
- Immunotherapy of Cancer
- Autobiography of a Face
- It Takes a Worried Man
Extra resources for Everybody's got something
For a while. But once he'd made it clear to me that the building we were in was empty for the weekend and nobody would hear me he'd removed the gag so I could beg him. My stomach twisted, remembering the other reasons he'd wanted my mouth free of obstructions, and I made myself a promise: I wouldn't think about the gory details any more. It had been over two years, and although the prosecutor had said Christophe had destroyed my life I was still among the living. True, the anonymity I'd sunk into after the initial public reaction to the crime was gone now, and I again felt uncomfortable walking the streets of New York.
Chapter Six At five to nine the next morning I cautiously opened the front door of the Warren Press office. The office in New York was all heavy antique furniture and oil paintings and exactly suited Fred's style. Here I saw pale blue walls and lots of glass and mirrors and furniture made of light wood in sleek lines. The place felt clean and fresh. It felt good. Comfortable. " A woman of about my age detached herself from the small group near the coffee maker in a corner and came over. Lucky for her she didn't completely resemble her dad, but she had his warm brown eyes and friendly smile so I knew who she was even before she held out her hand to me and said, "I'm Rhonda.
Never in a billion years would I have thought he'd be capable of what he did. If I could be that wrong about someone I loved, someone with whom I spent four years of my life, how could I ever be right about anyone? Hoping telling my story someday would answer that for me too, I replied to Lance. Lance, I have moved to Toronto and am absolutely not ready to do this now. However, at some point I will most likely be in touch. Thanks for understanding, Alexa As I sent that off, a new email arrived.


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Bottoms Up ft. Wiz Khalifa and Gucci Mane
Here’s the remix for Trey Songz Bottoms Up. Featuring verses from Gucci Mane and Wiz Khalifa, as well as a bit of a beat switch, its worth a listen. Lyrics are what you would typically expect from both parties but they lend well to the single. Gucci’s album drops Sept. 28 and Trey’s “Passion, Pain, and Pleasure” is out now.