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With a new decade arriving, DC president Jenette Kahn ordered a revamp in Wonder Woman's appearance. Artist Milton Glaser, who also designed the "bullet" logo adopted by DC in 1977, created a stylized "WW" emblem that evoked and replaced the eagle in her bodice and debuted in 1982. The emblem in turn was incorporated by studio letterer Todd Klein onto the monthly title's logo, which lasted for a year and a half before being replaced by a version from Glaser's studio. With sales of the title continuing to decline in 1985 (despite an unpublished revamp that was solicited), the series was canceled and ended in issue #329 (February 1986) written by Gerry Conway, depicting Steve Trevor's marriage to Wonder Woman.
Gaines didn’t know any of this when he met Marston in 1940 or else he would never have hired him: He was looking to avoid controversy, not to court it. Marston and Wonder Woman were pivotal to the creation of what became DC Comics. (DC was short for Detective Comics, the comic book in which Batman debuted.) In 1940, Gaines decided to counter his critics by forming an editorial advisory board and appointing Marston to serve on it, and DC decided to stamp comic books in which Superman and Batman appeared with a logo, an assurance of quality, reading, “A DC Publication.” And, since “the comics’ worst offense was their blood-curdling masculinity,” Marston said, the best way to fend off critics would be to create a female superhero.
Upon their arrival, the Dark Gods waste no time in making their presence felt. Right off the bat, we see Cheetah snap out of her slumber in a daze of rage, swearing off Urzkartaga, the god she once worshiped and now hates. Unable to be contained or controlled, she lashes out at anyone who stands in her way, making them pay with their blood. As she does so, she warns that new, dark gods are coming, and she needs to purge her connection to Urzkartaga in order to face them.
Having learnt of Wonder Woman's inability to return to Themyscira, Doctor Veronica Cale, a wealthy and powerful woman, set into motion a plan to use Wonder Woman to find Themyscira. Years earlier, Cale's daughter Izzy had her soul stolen by the gods Phobos and Deimos. They told Veronica that they would only return her daughter to her if she helped them find Wonder Woman, and got the location of Themyscira from her. Seeing no other option, Cale had formed a team called Godwatch, dedicated to locating Diana and Themyscira.


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Two vaccination clinics were held in the month of March. The clinics were carried out by the Wellness Committee in collaboration with the Yuma County Health Department, through the Esperanza Para Todos/Hope For All Program of the UnidosUS National Organization.
Vaccines applied in the 2 clinics = Moderna, Pfizer, Hepatitis A and Tdap (Tetanus)
Yuma County Health Department: Participated with staff of nurses for the application of vaccines and information table with Educators providing information about COVID 19
United US with the Hope for All program
Fire Department St. Luis, AZ
Yuma Catholic Services
Campesinos Sin Fronteras
Consulate of Mexico in Yuma
Approximately 400 people attended the two vaccination clinics satisfactorily on Thursday, March 3 and 31. In these clinics, first, second doses, booster and second booster were applied for people over 50 years of age or with chronic conditions. This booster is being applied to people 4 months after the first booster was applied. Also during the clinics, vaccines against COVID 19 were applied for children from 5 to 11 years old with the approval of the parents.
People from neighboring Mexico attended. Which came with different vaccines and Moderna or Pfizer were applied. The event continued with the approval of the combination of vaccines against COVID 19. All this in accordance with the specialists and health authorities. Other of the vaccines applied, was the Hepatitis A and Tetanus vaccine.
The next vaccination clinic will be on April 14, 2022 from 12pm-3pm.

domain: medical


- Lake Type: Natural Freshwater Lake, Not Dammed
- Length: ~19 miles
- Depth: maximum ~285 feet, average ~111 feet
- Area: 18,770 acres
- Trophic State: Oligotrophic
Torch Lake holds the distinction of Michigan’s longest inland lake (19 miles) and its second-largest inland lake (18,770 acres). Torch Lake is known for its incredibly beautiful and unique turquoise water, and its length makes it ideal for boating, tubing and jetskiing.
A hot spot during Northern Michigan Summers, the Torch Lake sandbar attracts boaters, locals, tourists, and party-people alike. Thousands visit the sandbar each summer to enjoy the company of others on their anchored boats in the shallow water playing games, grilling, and soaking up the sun. The white sand of the almost two-mile sandbar against the blue water makes for stunning vacation photos.
Torch Lake is a great location for boat and jetski rentals from TC Watersports!
Boat Launches near Torch Lake:


Artist: Maya Nelluri
Description: On Lord Shiva’s forehead, covered in lines of ashes, we find our whole world. His Trishul holds up our red circle of life.
Size: 56 x 33 inches
Medium: Mixed medium on canvas
Year : 2020
Washing : Wash inside out with cold water with similar colors using gentle cycle,use mild detergent, dry in shade.
Drying : Tumbler dry low or hang-dry.
Ironing : If ironing is necessary iron inside-out on the lowest setting.
Don'ts : Do not bleach, Do not dry clean.


Norway settles hotel tax dispute
NORWAY – Norway will lose several thousand dollars worth of taxes per year as part of a stipulation agreement with a local hotel that appealed its property value to the Michigan Tax Tribunal.
Calling the settlement a good compromise, members of the Norway City Council approved the agreement Monday with Norway Lodging Group, Inc., which owns the Norway Inn on U.S. 2.
According to information provided by Norway City Assessor Jim Waisanen, the Norway Inn property is assessed at a cash value of $1,288,800 and a taxable value of $644,000.
However, an appraisal submitted by Norway Lodging Group determined that the cash value of the property was only $550,000. The appraisal report cited a decline in business, due to the national recession and competition from other hotels in the area.
Based on the appraisal, information on recent hotel sales, and the results of recent Michigan Tax Tribunal cases, Waisanen advised that the city should settle the case instead of pursuing it further with the Michigan Tax Tribunal.
The stipulation agreement will reduce Norway Inn’s cash value from $1,288,800 to $700,000 and its taxable value from $644,000 to $350,000.
(Continued from page 1-A.)
Yearly tax loss to the city will be $4,030.70 in city taxes, $1,244.38 in money to the Downtown Development Authority, $173.74 in administration fees, and $147.20 in county road millage money, which goes into the city’s major streets and local streets funds.
Norway City Manager Ray Anderson drew a comparison between this case and Breitung Township’s current Michigan Supreme Court case against a tax reduction for the Home Depot store located within the township.
“The big box stores like Home Depot and Lowe’s have been successfully making these challenges and other businesses are following suit,” he noted in his memo to the council. “Large hotels are now starting this process and have been very successful in getting a favorable ruling from the tribunal.”
Council member George Bal asked if it would be prudent to wait for the outcome of Breitung Township’s case before settling with Norway Lodging Group.
Anderson explained that Norway’s case and Breitung Township’s case deal with entirely different classes of property. He added that the Michigan Tax Tribunal has been siding with hotels in these types of cases almost 100 percent of the time.
Despite the future loss in revenue, council members said that entering into the stipulation agreement was the best option.
“We’ll be getting more than if we went to the tax tribunal,” said Mayor Jeremy Oja. “It’s a better deal for us.”
In other business, the council:
– Agreed to enter into a five-year contract with Terrazzo Creations & Renewal of Norway for concrete restoration work at the city’s hydroelectric facility. Cost of the project will not exceed $80,000 per year, for a five-year total of $400,000.
Utility Superintendent Joe Pickart said that the project is budgeted. According to the plan, workers will repair concrete on the west powerhouse, side walls, wing walls, spillways, and main structure.
– Approved to pay up to $7,000 to Krause Power Engineering of Chippewa Falls, Wis. for miscellaneous engineering services throughout the year. Pickart noted that he usually only spends between $2,500 and $3,000 of that $7,000 budget each year.
– Agreed to spend up to $5,989 on a new golf cart and 11 new golf cart seats for the Oak Crest Golf Course. Council members Bal and Lee Meneghini voted against the motion.
Anderson said that course officials would like to bring the cart fleet up from its current number of 18 to a minimum of 20. The items are budgeted.
– Approved to pay up to $1,250 for Zambon Decorating Company of Iron Mountain to strip, sand, and stain 10 picnic tables at Marion Park. Zambon is currently in the process of re-staining the park’s pavilion.
– Reapppointed Oja to a two-year term as Norway’s representative on the Dickinson County Construction Code Commission.
– Heard Pickart report that the boulevard tree removal project has come to an end. A total of 133 dead or partially-dead trees were cut. Pickart added that workers are now in the process of grinding the leftover stumps.
Nikki Younk’s e-mail address is firstname.lastname@example.org.


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The sitting members in seven ALP electorates and one Greens-held seat are likely to be defeated once counting is finished in Queensland's state election.
Labor will be returned to power in Queensland despite a swing against it and is heading for a double-digit majority.
Anna Bligh has become the first elected female premier in Australian history , with her Labor government winning the Queensland election.
The swing away from Labor has ABC's election computer predicting the eight seats will all become Liberal National Party electorates.
They are Aspley and Clayfield, both in Brisbane's north; Burdekin, in north Queensland; Cleveland, in Moreton Bay; Coomera, on the Gold Coast; Hervey Bay, in the southern Queensland region; Indooroopilly, in Brisbane's western suburbs and Mudgeeraba, in the Gold Coast hinterland.

domain: news


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A strong buzz is currently being heard in film industry circles about Rana Daggubati’s participation in ace director S.S.Rajamouli’s upcoming project. The film will have Young Rebel Star Prabhas as the hero and Rana will reportedly be seen in a key role in this movie. Some people are even suggesting that Rana will play the negative role in the movie.
With his well built frame, Rana would be a perfect foe for Prabhas. Just imagine the effect on screen if these two hunks get into a raw physical fight in the film. The movie is currently in pre-production phase and shooting will start early next year.
The movie will have a period setting and will fall into the action adventure genre. Keeravani will be scoring the music and Arka Media banner is producing the project.
- Pawan vows to fight for AgriGold victims
- Bollywood beauty in talks for Akhil’s next?
- Rajamouli flags off Jagapathi Babu’s next
- Mister’s audio to have special chief guest
- Intriguing first look of Nithiin’s LIE raises curiosity
Articles that might interest you

domain: artistic


text:
If you can think it we can make it
Custom Mechanical Design
We are a young and ambitious team that has been operating for years in many industrial sectors. We have worked successfully both in Italy and abroad, seeking customer satisfaction through efficiency, punctuality, and flexibility. We employ best practices in CAD/CAM design and simulation. We can deliver any kind of mechanical design precisely and in a timely manner.
From hypercar aerodynamics simulation and optimization to product preliminary design, development, and industrialization our team can deliver any kind of mechanical project. We have a varied skillset and can rapidly deploy our specialists in order to quickly deliver your project at each development stage, whether it is a feasibility study, a preliminary design, prototyping, or a production-ready product.
We have completed projects across the whole spectrum of manufacturing sectors. Our diverse background, flexible attitude, and expertise let us innovate and complete even the most demanding product development projects. Our peculiar skills allow us to tailor the design around your needs while staying within your budget.
Industry Focused Services
We have a decade-long experience in aerodynamics simulation and optimization for the automotive and motorsport sectors.
We are specialized in CAD/CAM design. We employ state-of-the-art software and best practices to deliver easy-to-manufacture designs to the client.
We are pioneers in employing additive manufacturing techniques like FDM, STL and even DLP.
Product Design and Development
We can develop your project at any stage. We feature an in-house development team for industrial design.
We can design machines for many manufacturing processes in different fields, such as the healthcare and textile sectors.
Manuals and Documentation
We provide our clients with precise manuals and thorough documentation compliant with the relevant standards of the sector.
We can perform stress analysis on parts and assemblies to validate our designs or analyze third-party projects.
We provide industrialization and manufacturing solutions in order to scale up the potential of your idea.
We can coordinate tests of designs with specialized laboratories to verify compliance with relevant directives and standards.
We perform feasibility studies in order to provide the client with an assessment of costs and expected performance before resources are committed.
Prototyping and Test Runs
We are a production focused company. We will quickly produce mockup, functioning prototypes or setup a test run for each product.

domain: design


Dimensions & Weight
6' Super-King, 5' Kingsize, 4'6 Double, 4' Small Double, 3' Single
The Sleepeezee Backcare Luxury 1400 Pocket Mattress contains 1400 pocketed springs that distribute your weight evenly for great spinal support. Each spring is individually pocketed ensuring that any movement on one spring will not affect adjacent springs. This is very important in preventing any movement by a person on one side of the bed disturbing a partner on the other side of the bed.This mattress is tufted and filled with luxurious wool and silk for comfort.
This quality mattress has three rows of side stitching which helps to give the same support at the edge of the mattress as there is over the rest of the mattress. There are air vents built into the sides of the mattress to allow it to breathe and keep it from getting hot.
The Sleepeezee Backcare Luxury 1400 mattress has a medium firmness and does not need to be turned. It is advisable to rotate the mattress head to toe to ensure equal wear. This combines a supportive pocket sprung system with superior fillings and a luxury Belgian damask cover to make a quality sleep system for you and your body.


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FREEHOLD, N.J., Aug. 10, 2018 -- The New Jersey Chapter of the American Society of Interior Designers (ASID) will hold its 2018 Design Symposium & Industry Trade Show at Jersey City's Liberty Science Center on Wednesday, September 12. Themed, “Design I T: Design, It’s Our DNA,” the event promises to inform and inspire attendees and have them experience innovation firsthand.
The Chapter invites all area trade, including interior designers, architects, industrial designers and Industry Partners to participate in this stimulating day-long event. Members of other ASID chapters, the Interior Design Society (IDS), the National Kitchen & Bath Association (NKBA), the International Interior Design Association (IIDA), the American Institute of Architects (AIA) and the International Furnishings & Design Association (IFDA) are among those welcome.
The morning begins with a choice of two out of four CEUs that are sure to make everyone informed:
• Moen: The latest in shower design and technology (HSW credit & NKBA, AIA, GBCI-approved)
• Steelcase: Biophilia, Wellness and the Visual Environment (HSW credit)
• Steelcase: Speech, Privacy and Sound Masking (HSW credit & AIA-approved)
• Phyllis Harbinger: Getting Organized and Streamlining your Workflow
Then, the Keynote Luncheon features award-winning interior designer Ghislaine Viñas, who will speak about “Designing Happiness.” A firm believer in the “aesthetics of happiness,” she runs a unique and thriving design firm in New York City with a strong belief in collaboration and experimentation. Born in the Netherlands and raised in South Africa, her international background allows Ghislaine to design with an eyes-wide-open approach. Her designs push the boundaries of color, scale, and form in ways that continue to innovate, inform and inspire.
The Trade Show runs from 1:00 to 5:00 p.m. and will continue to inform and inspire attendees with the latest products and 70-plus resources.
Following, attendees can experience” Wonders of the Night Sky” in the newest and largest planetarium in our hemisphere. Last but not least, attendees can end the day by celebrating with live music, a Steinway and refreshments.
Blackman®, one of the Northeast’s largest distributors of luxury fixtures and so much more, with over 20 locations throughout New York, New Jersey and Florida, is a Platinum event sponsor. Porcelanosa, a global leader in the innovation, design, manufacture and distribution of tile, kitchen and bath products, is a Gold event sponsor. Media sponsors include Design NJ: New Jersey's Home and Design Magazine Aspire Design and Home and Design NJ: New Jersey's Home and Design Magazine.
"Design IT: It’s in Our DNA” promises to be our best event yet, allowing attendees to gain new insights in the field of design, cultivate new relationships and discover new products and resources in this stimulating, interactive environment," said Joan Ravasy, President of the New Jersey Chapter of ASID. "It’s also a great opportunity for our Industry Partners and others to exhibit their latest innovations to a receptive audience and to strengthen connections with the design community. Exhibitors and sponsors will enjoy never-before-seen opportunities for product and brand visibility."
The American Society of Interior Designers (ASID) believes that design transforms lives. ASID serves the full range of the interior design profession and practice through the Society’s programs, networks, and advocacy. We thrive on the strength of cross-functional and interdisciplinary relationships among designers of all specialties, including workplace, healthcare, retail and hospitality, education, institutional, and residential. We lead interior designers in shared conversations around topics that matter: from evidence-based and humancentric design to social responsibility, well-being, and sustainability. We showcase the impact of design on the human experience and the value interior designers provide. ASID was founded 40 years ago when two organizations became one, but its legacy dates back to the early 1930s. As we celebrate nearly 85 years of industry leadership, we are leading the future of interior design, continuing to integrate the advantages of local connections with national reach, of small firms with big, and of the places we live with the places we work, play, and heal. Learn more at asid.org.


M. Fontul, A.M.R. Ribeiro, J.M.M. Silva, N.M.M. Maia, "Transmissibility Matrix in Harmonic and Random Processes", Shock and Vibration, vol. 11, Article ID 438986, 9 pages, 2004. https://doi.org/10.1155/2004/438986
Transmissibility Matrix in Harmonic and Random Processes
The transmissibility concept may be generalized to multi-degree-of-freedom systems with multiple random excitations. This generalization involves the definition of a transmissibility matrix, relating two sets of responses when the structure is subjected to excitation at a given set of coordinates. Applying such a concept to an experimental example is the easiest way to validate this method.
Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Komatsu announced plans for a construction project adding a new, nearly 50,000sq ft warehouse to its service center campus in Elko, Nevada. The warehouse will expand local parts support for mining and construction customers in the Nevada region.
Planned for completion in early 2024, the new warehouse will be located adjacent to Komatsu’s 189,000sq ft (57,600sq m) $47m state-of-the-art Elko service center, built in 2019. The service center has expanded the company’s ability to support construction equipment and large mining equipment including haul trucks, hydraulic shovels, electric rope shovels and mining support equipment. The new warehouse will replace an existing warehouse on the site.


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To make the apples you need to melt the caramels according to the package directions. Use a bowl that isn't much bigger than the apple.
If you just want nuts, you can then roll it (while the caramel is hot) around on a plate of nuts. I also think that rolling it in granola is great. It's kind of like an apple crisp caramel apple.
Today I made a TURTLE APPLE. After dipping it in the caramel, I rolled it in pecans. Then I dipped it is melted dark chocolate.
WHITE CHOCOLATE CASHEW CRANBERRY APPLE
For this apple, I dipped it in white chocolate, rolled it in cashews and cranberries and then drizzled more caramel and dark chocolate over the apple.
I love the look created by making a bow onto the apple stick.
It is also really fun and colorful to roll them in sprinkles.
When you add nuts, you will get a lumpy apple. For the really smooth look, stick to chocolate or caramel. Another great idea that is really cheap and easy is to use frosting. If you take a jar of premade frosting and microwave it for about 15-30 seconds so that it starts to melt you can dip the apple in it. This is a nice option for little kids because it is much softer than caramel.
I made 6 apples for $20.00. I know that sounds pricey, but it was mostly due to the cost of the nuts. Also, I have left over nuts, so it really was more like $15.00 for 6. Gourmet apples purchased at the store or online start at $11.00. The pecan version that I made is about $19.00 an apple online. Same with the cranberry version. So, basically you are making 6 apples for the price of one.
SOME FLAVOR IDEAS
Smores - Graham Crackers, mini marshmallows and milk chocolate
Black Forest - Caramel, dried cherries, and dark chocolate
Buckeye - caramel, rice crispies, and peanut butter
Rolled in Caramel Corn
Rolled in Chopped Candy Bars
German Chocolate - coconut, caramel, and chocolate
Rolled in M&Ms
Rolled in Crushed Cookies - Oreos, Pecan Sandies, etc.
SOME DECORATING IDEAS
Mrs. Prindables, you can pay $30.00 and get an apple with a little stuffed animal on top. You could easily do this yourself. They also put flowers on the sticks. Another idea would be to make an edible figurine out of fondant or modeling chocolate.

domain: food


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What is pre-exposure prophylaxis (PrEP)?
PrEP is a new HIV prevention method that involves HIV negative people taking anti-HIV medications daily to help prevent HIV
infection. Several studies have shown that PrEP can reduce the risk of becoming HIV-infected when taken as part of a package of prevention services. One of these studies showed that PrEP was safe and effective for HIV prevention in gay and bi men and transwomen in San Francisco and other parts of the world.
What’s in the pill?
Truvada contains two medications, tenofovir and emtricitibine. Truvada is commonly used to treat HIV positive individuals in combination with other anti-HIV medications. Truvada was approved by the Food and Drug Administration (FDA) in July 2012 for the prevention of HIV-infection in HIV-negative men and women.
Is it safe?
From what we know so far, Truvada for PrEP is safe and well tolerated.
About 1 in 10 people in the PrEP studies reported that they had headache, stomach pain, or weight loss when they first started taking Truvada. In most people, these side effects improved or went away after they’d been taking the Truvada for a few weeks.
A small number of people had a slight decrease in kidney function that normalized when they stopped the medication. Small losses of bone density (thickness) have been seen in people taking Truvada. These changes have not been associated with an increase in fractures in these studies.
Is PrEP being offered at San Francisco City Clinic?
PrEP is not currently being offered at San Francisco City Clinic. We completed enrollment for our PrEP demonstration project
in November 2013. We are working on setting up a PrEP program at the clinic, and will update this site with more information as soon as it is
available. City Clinic DOES offer post-exposure prophylaxis (PEP).
Where I can get PrEP?
Ask your doctor about PrEP!
- Truvada for PrEP is covered by many private insurance plans.
- Truvada for PrEP is covered by Healthy San Francisco. If you are enrolled in Healthy San Francisco, talk to your doctor about prescribing it to you.
- If you are currently uninsured and are a San Francisco resident, you may be eligible for Healthy San Francisco. For more information about how to enroll: http://www.healthysanfrancisco.org.
- California residents may be eligible for insurance through the new insurance marketplace established by the Patient Protection and Affordable Care Act. Visit the Covered California website for more info: http://www.coveredca.com.
- If you are currently uninsured, you may be eligible to get Truvada for PrEP through a patient assistance program. More information is available at: http://www.truvada.com/truvada-patient-assistance. Bring this form to your doctor: https://start.truvada.com/Content/pdf/Medication_Assistance_Program.pdf.
We will be updating this site with more information about where and how to access PrEP in San Francisco as more information becomes available.
For more information about PrEP:


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Human immunodeficiency virus (HIV) vaccine development remains a global priority. We describe the safety and immunogenicity of a multi-clade DNA vaccine prime with a replication-defective Adenovirus type 5 (rAd5) boost.
The vaccine is a 6-plasmid mixture encoding HIV envelope (env) subtypes A, B and C and subtype B gag, pol and nef, and a rAd5 expressing identical genes, with the exception of nef. Three hundred and twenty-four participants were randomized to receive placebo (n=138), a single dose of rAd5 at 1010 (n=24) or 1011 particle units (n=24), or DNA at 0, 1 and 2 months followed by rAd5 at either 1010 (n=114) or 1011 particle units (n=24) boosting at 6 months. Participants were followed for 24 weeks after the final immunization.
The vaccine was safe and well tolerated. HIV-specific T cell responses were detected in 63% of vaccinees. Pre-existing Ad5 neutralizing antibody titer did not impact the frequency and magnitude of T cell responses in prime-boost recipients, but did impact the response rates in participants receiving rAd5 alone (p=0.037).
The DNA/rAd5 immunization regimen was safe and induced HIV-1 multi-clade T cell responses, which were not significantly affected by pre-existing rAd5 neutralizing antibody titer.
The HIV epidemic continues to grow with 33 million persons living with HIV/AIDS and an additional 7,400 new infections daily in 2007 . While multiple HIV prevention strategies have been evaluated with some recent successes [2, 3], a vaccine to prevent HIV infection, or alter disease course, remains the cornerstone of a successful global HIV control program. Despite the failure of the VaxGen and Merck candidate HIV vaccines in efficacy testing [4–6], there is consensus that both basic discovery and clinical research pursuing a vaccine is justified . A vaccine that induces primarily T cell immunity may only afford a reduction in viral burden among recipients based upon animal model studies, yet be a valuable contribution to HIV control programs by slowing disease progression and reducing the rate of secondary infections [8, 9].
The Vaccine Research Center (VRC), National Institutes of Allergy and Infectious Diseases candidate HIV vaccine is a multi-clade HIV DNA prime vaccine expressing HIV-1 Gag, Pol, Nef and Env proteins, boosted with recombinant Adenovirus type 5 (rAd5) expressing matching proteins with the exception of Nef. The VRC DNA/rAd5 vaccine was designed for induction of HIV specific T cell immunity, to ideally prevent HIV acquisition and, failing that, to reduce viral load in vaccine recipients who did become infected . Unlike the Merck vaccine, which failed to provide benefit in efficacy testing, the VRC prime-boost candidate provided a survival benefit in non-human primate studies using a homologous, intravenous, pathogenic SIV challenge [11–14]. Both the VRC HIV DNA prime and the rAd5 vaccines were safe, well-tolerated and immunogenic when administered separately to HIV uninfected adults in the US [15, 16].
The VRC HIV DNA/rAd5 vaccine was evaluated for safety and immunogenicity in three studies among lower risk populations of HIV uninfected adults in the US, Caribbean, South Africa and East Africa to establish safety and immunogenicity at sites similar to those which might provide higher risk volunteers for efficacy testing of the vaccine. The combined data from these studies were considered sufficient to determine whether this candidate vaccine should proceed to proof of concept efficacy testing . Here we describe one of these studies assessing safety and immunogenicity of a replication-defective rAd5 administered alone or following priming with a multi-clade DNA in East African populations with high pre-existing Adenovirus 5 (Ad5) neutralizing antibody titers.
RV 172 was a randomized, double-blinded placebo-controlled trial performed at three clinical research sites: the Makerere University-Walter Reed Project (MUWRP), Kampala, Uganda, the Walter Reed Project (WRP), Kericho, Kenya and the Mbeya Medical Research Programme (MMRP), Mbeya, Tanzania. The protocol was approved by ethical review boards in each country and the US Department of Defense. All volunteers provided written informed consent. The trial was conducted in two parts as shown in Table 1. Part A, a phase I study in 144 volunteers (Groups 1–4) evaluated rAd5 at two doses, 1010 and 1011 particle units (PU)/mL, administered as a single dose alone (Groups 1 and 2, respectively) or as a boost following three injections of the DNA prime vaccine (Groups 3 and 4, respectively). Two dose regimens of rAd5 were evaluated to provide information about the safety and immunogenicity of this vaccine in African populations where pre-existing neutralizing antibody to the vector is common . Part B, a phase II study in 180 volunteers, further defined safety, tolerability and immunogenicity for the preferred prime-boost combination for efficacy testing (Group 5). In Part B, participants were randomized to either vaccine or placebo at a ratio of 1:1. Solicited adverse events (AE) commonly associated with vaccination and unsolicited AE, including a battery of blood and urine tests, were assessed at clinical encounters with volunteers 2 weeks after each vaccination and 4, 6, 12 and 24 weeks following the final immunization.
The VRC vaccines have been previously described [15, 16]. Briefly, the VRC DNA-HIV vaccine (VRC-HIVDNA016-00-VP) and VRC rAd5-HIV vaccine (VRC-HIVADV014-00-VP) contain largely matched HIV gene inserts, but they are not identical. VRC-HIVDNA016-00-VP (Vaccine Research Center, Bethesda, MD, USA) is composed of six closed, circular, DNA plasmids: three plasmids expressing HIV-1 Gag, Pol and Nef proteins from clade B and representing 50% by weight; and three plasmids each expressing HIV-1 Env glycoprotein from clades A, B and C, and representing the other 50% by weight (16.67% each). VRC-HIVADV014-00-VP (Vaccine Research Center, Bethesda, MD, USA), is composed of four replication-defective, recombinant serotype 5 adenoviral vector composed of four rAd5 vectors (in a 3:1:1:1 ratio) encoding HIV-1 Gag/Pol polyproteins from clade B and HIV-1 Env glycoproteins from clades A, B, and C. The envelope genes were chosen as representative primary isolates from each of the three clades. Mutations and deletions were introduced into HIV genes to preclude expression of functional proteins. Envelope sequences were truncated and the DNA plasmids and rAd5 vectors express gp145 (cytoplasmic tail deleted) and gp140 (transmembrane domain and cytoplasmic tail deleted) envelope proteins, respectively. In addition, the EnvB construct in the rAd5 had a V1/V2 deletion not present in the DNA product. The DNA vaccine was delivered intramuscularly in a dose of 4 mg using a needle free injection system (Biojector, Bioject Incorporated, Bedminster, NJ, USA). The rAd5 vaccine (1ml) was delivered intramuscularly by needle injection in a dose of either 1010 or 1011 PU/mL.
Monitoring for HIV-1 infection was performed using a sequential algorithm of the following U.S. FDA approved tests: Genetic Systems rLAV ELISA (BioRad Laboratories, Redmond, WA), Vironostika HIV-1 Microelisa (BioMerieux, Durham, NC), Genetic Systems HIV-1 Western Blot Kit (BioRad Laboratories) and Amplicor HIV-1 Monitor version 1.5 RT-PCR (Roche Diagnostics, Indianapolis, IN).
Sera collected from participants prior to vaccination were used for determining Ad5 Nab titers. A validated assay was performed at the NIAID Vaccine Immune T-cell and Antibody Laboratory (NVITAL, Gaithersburg, MD, USA), a contract laboratory supporting NIAID funded clinical vaccine trials. Serum dilutions, ranging from 1:12 to 1:8748, were incubated with a luciferase reporter rAd5 for 30 minutes and added to A549 (human lung carcinoma) cells. Following incubation for 24 hours, luciferase activity was assessed. The 90% inhibition serum titer was determined to be the serum dilution, which can be interpolated to have 10% of the maximum luciferase activity relative to the assay run in the absence of serum.
Peripheral blood mononuclear cells (PBMC) were prepared from acid-citrate dextrose anti-coagulated tubes by Ficoll-Hypaque PLUS density gradient centrifugation (Pharmacia, Uppsala, Sweden) using Leucosep tubes (Greiner Bio-one, Essen, Germany) within 8h of collection. PBMCs were cryopreserved in RPMI medium (Sigma, St. Louis, MO) containing 20% heat-inactivated fetal-calf serum and 10% dimethylsulfoxide (DMSO;Sigma) in a Cryo 1°C freezing container (Nalgene, Rochester, NY). Cells were stored at ≤ −140°C. Immunogenicity assessments were performed on thawed specimens; average cell viability was >94% immediately after thawing.
PBMC were thawed and rested overnight prior to testing. The IFN-γ ELISpot assay was performed at a central laboratory as previously described  HIV peptides of 15-mer overlapping by 11 amino acids were prepared and divided into 5 peptide pools, representing Env (clades A and B), Pol 1 and Pol 2 (clade B) and Nef (clade B) (Vaccine Research Center, NIH, Bethesda, MD). These peptide pools matched the vaccine HIV gene products. An Env C peptide pool was kindly provided by the International AIDS Vaccine Initiative (IAVI) and HIV clade B-Gag (LAI) was from New England Peptide LLC (Gardner, MA). All peptides had a purity of >85% as measured by high performance liquid chromatography and mass spectrometry. All peptides were used at a final concentration of 1μg/ml. Since all peptides were reconstituted in DMSO, wells containing PBMC and media only were supplemented with the equivalent concentration of DMSO and served as negative controls. Phytohemagglutinin (PHA;Sigma) was used as a positive control. PBMC plus peptide antigens or PHA were tested in 3 replicate wells. Negative controls were performed in quadruplicate. Spots were counted with a C.T.L. analyzer (Shaker Heights, OH) and software (version 4.0.19, C.T.L. Analyzers). Results are expressed as spot-forming cells (SFC)/106 PBMC. A positive IFN-γ response was defined as at least 55 SFC/106 PBMC (uncorrected) and at least 4 times the DMSO treated wells . The assay was scored as invalid if PHA treated PBMC failed to produce a positive response and/or the negative control was ≥ 55 SFC/106 PBMC.
Comparisons of reactogenicity and adverse events were made by assigning scores of 0, 1, 2 and 3 to severities of none, mild, moderate and severe, respectively. The Wilcoxon Rank sum test was used for 2 group comparisons. Otherwise, the Kruskal-Wallis test was used. Fisher’s exact test was used for 2 by 2 tables. All comparisons were based on the maximum severity per volunteer. The proportion of volunteers with positive ELISpot responses was tested using Fisher’s exact test. The Cochran-Armitage test for trend was used to compare responses rates across increasing pre-immunization Ad5 Nab titer. The magnitude of ELISpot responses was tested by ANOVA on log10 response. All tests are 2-tailed and all analyses were performed using SAS.
Enrollment and vaccination of 324 volunteers commenced in May 2006 and was completed in October 2006 with 144, 120 and 60 participants at the Ugandan, Kenyan and Tanzanian sites, respectively. The average age was 28 years (range 18–49) and 103 (32%) participants were female. Three hundred and eleven (96%) participants completed the 12-month study and 13 (4%) terminated the study before the final visit. Nineteen (6%) participants did not complete the vaccination schedule (8 placebo and 11 vaccine recipients). The most common reason for discontinuation of vaccination was pregnancy (N = 8). Two individuals prematurely stopped vaccination due to adverse events (one vaccine recipient for urticaria, and one placebo recipient for generalized itching). No deaths occurred during the 12 months of the study. A single HIV infection was observed during the study period in a vaccine recipient. All traceable volunteers were offered counseling and HIV testing following public disclosure of the Merck STEP study results and 264 (81%) attended briefing and VCT sessions. A total of 4 additional HIV infections have been identified in extended follow-up (one vaccine recipient and 3 placebo recipients) yielding an overall infection rate of 0.611 per 100 person-years observation. The infection rate observed by MHRP in community cohort studies at or near these research sites have ranged from 0.77 to 1.8 per 100 person-years observation (M. Hoelscher, personal communication;).
Vaccinations were well tolerated (supplemental figure 1). Solicited local and systemic adverse events were commonly reported by both vaccine (88% for both) and placebo recipients (80% for both). The frequency and severity of local and systemic solicited adverse reactions was not different between the high and low dose of rAd5 either alone (p=0.440 and 0.367 for local and systemic adverse events, respectively) or in the prime-boost regimen (p=0.458 and 0.803 for local and systemic adverse events, respectively). The presence and titer of pre-existing antibody to Ad5 did not alter the frequency or severity of solicited local or systemic adverse events among vaccine recipients (data not shown, p=0.767 and p=0.938 respectively). There were no differences between vaccine and placebo recipients in the frequency or severity of routinely collected clinical laboratory measures (data not shown).
A total of 1446 AE were reported among 309 of 324 participants. Infectious diseases were the predominate adverse events with upper respiratory tract infections most common followed by malaria, urinary tract infections and gastroenteritis. Blood disorders were the second most common diagnoses led by neutropenia and thrombocytopenia. Adverse event rates were similar among placebo and vaccine participants. 62 adverse events were graded as severe or life-threatening and malaria and neutropenia were the most common diagnoses. The proportion of severe or life-threatening adverse events among vaccine and placebo participants were similar (4.9% versus 3.4%, p =0.159). Four of these, all occurring in vaccine recipients, were considered possibly or probably related to vaccine. These were two cases of generalized urticaria, an episode of neutropenia and an episode of malaise. There was no relationship between the frequency or severity of adverse events and the titer of pre-existing adenovirus antibody for either placebo or vaccine recipients (data not shown).
Responses to HIV antigens were measured using IFN-γ ELISpot prior to and 6 weeks after either a single rAd5 injection or the DNA/rAd5 regimen. Results from groups 3 and 5 were combined (3/5) as they evaluated the same regimen. Fifteen study participants who did not complete vaccination as assigned per protocol were excluded from analysis and in some cases, insufficient cells for analysis resulted in further missing data points.
IFN-γ ELISpot response frequencies post-vaccination for each peptide pool and for any positive response are shown for placebo and vaccine recipients by study group in Table 2. False positive rates from placebo (7/121;6%) and baseline samples were low for all peptide pools evaluated together (9/275; 3%, data not shown). The response rates to any peptide pool for the low and high dose rAd5 alone were 74% and 52% respectively (p=0.221). Similarly, response rates for DNA prime and low or high dose rAd5 boost were 63% and 60% respectively (p=0.806). Positive IFN-γ ELISpot responses to any Env, Gag or Pol peptide pool at 6 weeks following rAd5 alone (groups 1 and 2) and DNA/rAd5 (groups 3, 4 and 5) were 29 of 46 (63%) and 78 of 125 (62%), respectively and were not significantly different. Response rates for each Env peptide pool were not different between the Ad5 alone and prime-boost groups. The Env pools matching the vaccine amino acid sequence elicited better response rates compared to the subtype C Env peptide pool regardless of study group. The frequency of Gag responses in the rAd5 alone group was significantly less than that in the DNA/rAd5 groups, (3/45 versus 41/124; p < 0.001). Pol responses were more common in the rAd5 alone groups compared to the DNA/rAd5 groups, (15/45 versus 19/120; p=0.018).
There was no difference in the magnitude of response measured by IFN-γ ELISpot among the four regimens examined in the study (Figure 1, p=0.254). The median (range) responses were 127 (60–493), 141 (70–463), 163 (55–2103) and 236 (58–1007) SFC/106 PBMC in Groups 1, 2, 3/5 and 4, respectively. There was no difference between low and high dose rAd5 alone, (arm 1 versus arm 2) or in a prime/boost format between arms 3/5 and 4 in terms of response frequency or magnitude. Analyzing these data with stratification for pre-existing Adenovirus antibody titers shows no significant differences but these results must be interpreted with caution given the small numbers of such a comparison (data not shown). The proportions of volunteers with responses to combinations of Env, Gag and/or Pol peptides are shown in Figure 2. The frequency of positive responses was predominantly to Env, followed by Pol or Gag, regardless of immunization regimen. Among the four regimen groups, roughly equal proportions recognized two antigens (20%–26%). Group 4, with the high dose rAd5 boost had the highest frequency of responders to all three antigens tested (20%, p = 0.137).
Ad5 Nab was present at baseline in 175 of 186 vaccine recipients (94%) with a median titer of 2385. After substituting a value of 8750 for titers reported as >8748, the corresponding median and geometric mean were 3521 and 1407, respectively. Positive IFN-γ ELISpot response rates to HIV Env, Pol or Gag peptide pools among vaccine recipients only, stratified by Ad5 Nab titer, are shown in Table 3. The frequency of response to any HIV antigen after rAd5 immunization alone was 3 of 4 (75%) for participants with negative Ad5 Nab titers, 14 of 18 (78%) for participants with Ad5 Nab titers of <1000, 7 of 12 (58%) for those with titers 1000 to 5000, and 5 of 12 (42%) for those with titers > 5000 (p=0.048). Pre-existing immunity to Ad5 had no effect (p=0.252) on HIV-specific response rates in prime and boost recipients where 6 of 7 (86%) with negative Ad5 Nab titers had a positive IFN-γ ELISpot response, compared with 24 of 39 (62%) with Ad5 Nab < 1000, 27 of 41 (66%) of those with titers 1000 to 5000, and 21 of 38 (55%) of those with titers over 5000. The magnitude of IFN-γ ELISpot responses for groups 1 and 2 combined and groups 3, 4 and 5 combined and stratified by baseline Ad5 Nab titer is shown in Figure 3. A modest reduction in magnitude with increasing Ad5 Nab titer is apparent, though not statistically significant for both single rAd5 vaccination (p=0.184) and the prime boost regimens (p=0.595).
The HIV vaccine field has achieved only incremental progress, which has been in the form of negative studies defining conceptual approaches that do not lower acquisition risk or reduce viral load. The benefit of a vaccine that would modestly reduce viral load, even if it confers no protection from acquisition could be significant. In addition to extending the interval before initiating anti-viral therapy, decreasing host viral burden is likely to reduce secondary HIV transmission [21, 22]. The current study examines the clinical and immunological characteristics of a novel candidate DNA plasmid prime/rAd5 vector boost vaccine combination that is distinct from the vaccines that have failed in test of concept efficacy trials [4–6].
The VaxGen monomeric gp120 vaccine was able to induce neutralizing antibody to T cell line adapted variants of HIV but unable to generate antibody responses to the most commonly transmitted variants of HIV [5, 6]. The Merck vaccine was designed to elicit HIV specific T cell immunity and produced HIV-specific responses which were predominantly CD8+ T cells and only 31% of recipients showing both CD8+ and CD4+ T cell responses . In non-human primates, the Merck vaccine produced marginal reduction of viral load following SIV challenge . In contrast, the VRC candidate reported here, is a heterologous vector strategy employing a DNA prime and rAd5 boost and has shown both a reduced level of post-challenge viremia and a survival benefit in non-human primate SIV challenge studies. Interestingly, this survival benefit was correlated to induction of total HIV specific T cell responses, CD8+ T cell responses, CD4+ T HIV-specific IFN-γ ELISpot responses and preservation of central memory CD4+ T cells [11, 13]. Similar to observations in the non-human primate challenge study, intracellular cytokine staining of a subset of volunteers in this study identifies a balanced CD4+ and CD8+ T cell response to rAd5 following DNA priming [12, 24].
The data presented here, show that the VRC rAd5, and DNA/rAd5 HIV vaccines are safe and well tolerated in a population within resource-constrained settings experiencing a significantly greater burden of endemic illness. Vaccination with rAd5 alone or in a prime-boost combination with DNA was highly immunogenic despite very high prevalence and titer of antibody to Ad5 at study entry. A similar study in the United States using the identical rAd5 immunogen, dose and regimen described here for groups 1 and 2 demonstrated nearly identical IFN-γ ELISpot response frequencies to HIV antigens as this study, supporting the use of this immunogen in a global setting . A diminution in the magnitude of the ELISpot responses with increasing Ad5 Nab has been previously reported for rAd5 vaccines [15, 23]. While the overall frequency of responders to all HIV antigens was similar between the rAd5 only and prime-boost recipients, there was a reduction in response frequency in the rAd5 only groups with rising baseline Ad5 titer. The prime-boost strategy induced a higher frequency of responders than the rAd5 group in subjects with rAd5 Nab titers ≥1000. Surprisingly, there was no evidence of benefit to the higher 1011 dose of Ad5 vector compared to the lower 1010 dose in either the rAd5 only or the prime-boost combination. In terms of overall frequency and magnitude of cellular immune responses as measured by IFN-γ ELISpot, the rAd5 alone performed as well as the prime boost regimen, with the exception of Gag responses, where the frequency of responders in the prime-boost regimen was almost 5 times that of the single rAd5 immunization.
It has been argued that a more rigorous animal model would utilize a challenge that is genetically divergent from the strain used to design the test vaccine. However, it is not known whether the non-human primate model will be predictive of protection in humans and if so, under what experimental conditions. It remains necessary to examine the efficacy of products, which are safe and distinct from previous vaccine candidates as a complimentary avenue of discovery to validate pre-clinical testing paradigms. In view of the Step study results, the VRC DNA prime and rAd5 boost vaccine is expected to enter efficacy testing in the US only among circumcised males without evidence of pre-existing immunity to Ad5. Although the population under evaluation in this study is not part of the initial test of concept efficacy trial in view of the low rates of circumcision and high prevalence of Ad5 antibody, it will be an important component of other studies should evidence of efficacy be demonstrated.
We wish to thank the study volunteers, the study staff and Alberto Ortiz, Dr. Chuen-Yen Lau, Dr. Alan Fix and Dr. Robert Gramzinski.
This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). The study was funded and sponsored by the Division of AIDS, NIAID, NIH, DHHS. The views expressed are those of the authors and should not be construed to represent the positions of the U.S. Department of Defense.
The authors do not have a commercial or other association that might pose a conflict of interest.
This data was presented in part as abstract P13-23 at “AIDS Vaccine 2008”, 13–16 October, 2008 in Capetown, South Africa.
http://clinicaltrials.gov - registry number NCT00123968

domain: literature


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New Directions in Research and Care is New Jersey’s largest and most successful dementia-specific education program for healthcare professionals. The conference inspires healthcare professionals to improve treatment and care for individuals with Alzheimer’s disease, to stimulate new methods of providing care in facilities and in the homes of Alzheimer’s families, and to share the most recent trends in dementia research.
The 2018 Education & Research Conference will be held on Wednesday, April 18 at The Palace at Somerset Park in Somerset, New Jersey. We hope you can join us for this significant event. Details to follow in the weeks ahead.
Richard S. Isaacson, M.D.
Director, Alzheimer’s Prevention Clinic,
Weill Cornell Memory Disorders Program
Associate Professor of Neurology, Weill Cornell Medicine
Director, Neurology Training Program, Weill Cornell Medicine/NewYork-Presbyterian Hospital
Care and Support Plenary:
Pauline Boss, Ph.D.
Professor Emeritus, University of Minnesota
Fellow, American Psychological Association
Fellow, American Association for Marriage and Family Therapy
Family Therapist, Private Practice
Jill S. Goldman, MS, MPhil, CGC
Genetic Counselor, Senior Staff Associate
Taub Institute, Columbia University Medical Center, NY, NY


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May Day – May 1st – is International Workers’ Day, a day established to commemorate labour struggles by workers around the world since the mid-19th century, when the fight for the 8-hour day cost the lives of many of those active in their labour movements.
Join us May 1st on Parliament Hill at 1pm as we take to the streets with United Steelworkers – Local 1005 from Hamilton, many of whom are currently locked out from their workplace. The attack on Local 1005 members by the employer, U.S. Steel, is part of a larger global attack on all workers around the world across all industries. These attacks include union-busting, cuts to wages, benefits, and pensions and affect all workers.
An injury to one is an injury to all.
Whether you work in a unionized shop or not, an attack on workers is an attack on you. These attacks are lowering the standards of employment and raising profits for employers not being properly held accountable for the effects their practices are having on society and the world.
Later, the Ottawa Panhandlers’ Union will be hosting a Street Art Auction, 6-8pm, 2nd floor of the Jack Purcell Community Centre (off Elgin, near Gilmour). Come out and support your local street artists at a time when Ottawa’s business and political interests side with wiping out the city’s street culture.


One of the world’s biggest, multi-platinum selling, Christian bands, Casting Crowns, will be live in South Africa this June, in association with Radio Tygerberg, Groot FM and Christian Art Media. The Atlanta, Georgia based group will be in Cape Town on June 26 at the GrandWest Arena, in Johannesburg on June 27 at Rhema Church, and in Pretoria on June 28 at Moreletapark Gemeente. Johannesburg and Pretoria tickets are currently on sale and Cape Town ticket sales will open on the April 7. Tickets can be booked through itickets.co.za. Ticket prices range from R175 to R275.
It has been six years since the seven members of the Grammy Award winning outfit performed live in South Africa. “Due to the continuous demand for their music on radio stations and extraordinary album sales locally we decided to give their SA fans a huge surprise and bring them out” says, Hardus Zevenster, Radio Tygerberg tour promoter.
Casting Crowns’ has consistently delivered songs that spur listeners to evaluate their relationship with God and with each other. Their 13th album “Thrive” released in January 2014, hearing Casting Crowns’ frontman Mark Hall singing those words in the title track, it’s hard not to feel peace wash over your soul. Life can be so challenging and it’s easy to become overwhelmed. What a gift to be reminded we were made to thrive!
Since arriving in 2003 with its self-titled Beach Street/Reunion Records debut album, the GRAMMY winning band has also earned 17 Gospel Music Association Dove Awards. The group has been awarded one RIAA 2x multi-Platinum album, three RIAA Platinum albums, two RIAA Platinum DVDs, six RIAA Gold albums, four Gold DVDs and four RIAA Gold certified digital singles. Casting Crowns has toured extensively internationally, performing concerts in 21 countries.
“To be on a plane for nine hours and get somewhere and they are singing your song still amazes me,” Hall says. “Wherever we go, we want to spend some time with the youth workers and encourage them in how to disciple teenagers. We’re not just going over singing songs, which is awesome, but influencing the influencers who are going to be there when we are gone, to me is massive. The basic idea is let God define himself throughout everything we do, and if we do that, we all will thrive together.”
It’s been more than 10 years since the members of Casting Crowns heard their first single on the radio in July 2003. Since then so much has happened in the lives of each member and along the way God has taught them so much. “He’s opened our eyes to our suspicion that He was way bigger than we thought He was,” Hall says with a smile. “He didn’t need Casting Crowns to come along to help His word get out. God is winning. He’s changing the world. It may look at times like things are getting darker and darker, but they are not. Everywhere you go, you can see light and light wins. It always wins.”


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Did Egyptians have mid-wives?
19 And the midwives said to Pharaoh, "Because the Hebrew women are not like the Egyptian women; for they are lively and give birth before the midwives come to them.
If Satan came from Heaven why would he not recognize Jesus?
6 And said to Him, "If You are the Son of God, throw Yourself down. For it is written: 'He shall give His angels charge over you,' and, 'In their hands they shall bear you up, Lest you dash your foot against a stone.'
Was this the same Mark Paul did not want take with him in Acts?
Were fish on the Ark?
Is suffering really part of God’s will for our lives?
1 Peter 4:19
19 Therefore let those who suffer according to the will of God commit their souls to Him in doing good, as to a faithful Creator.
Is this referring to coals?
5 Take the choice of the flock. Also pile fuel bones under it, Make it boil well, And let the cuts simmer in it.
17 And when I saw Him, I fell at His feet as dead. But He laid His right hand on me, saying to me, " Do not be afraid; I am the First and the Last.
Is Jesus talking about the dead?
35 But those who are counted worthy to attain that age, and the resurrection from the dead, neither marry nor are given in marriage.
6 I said, "You are gods, And all of you are children of the Most High.


Research during recent years has revealed that human errors are not stochastic events which can be removed through improved training programs or optimal interface design. Rather, errors tend to reflect either systematic interference between various models, rules, and schemata, or the effects of the adaptive mechanisms involved in learning. In terms of design implications, these findings suggest that reliable human-system interaction will be achieved by designing interfaces which tend to minimize the potential for control interference and support recovery from errors. In other words, the focus should be on control of the effects of errors rather than on the elimination of errors per se. In this paper, we propose a theoretical framework for interface design that attempts to satisfy these objectives. The goal of our framework, called ecological interface design, is to develop a meaningful representation of the process which is not just optimised for one particular level of cognitive control, but that supports all three levels simultaneously. The paper discusses the necessary requirements for a mapping between the process and the combined action/observation surface, and analyses of the resulting influence on both the interferences causing error and on the opportunity for error recovery left to the operator.


The site of the world's largest student accommodation tower – Scape's 61-level, 740-bed building in central Melbourne – remained closed on Monday after it shut for deep cleaning last week when four employees of a concreting subcontractor tested positive to COVID-19.
Contractor Built's 99 Franklin Street site closed after the I&D Group employees tested positive. The cleaning process was completed on Friday, but the site needed sign-off from Victoria's Department of Health and Human Services to resume work, which sources said it received late on Monday.
"We were advised on Monday 3 August following proactive testing of workers and have been cooperating in full with DHHS since then," a Built spokeswoman said on Monday.
I&D founder Ivan Filipovic told The Australian Financial Review all 60 of his staff working on the Scape site were serving out a two-week period of isolation. Scape declined to comment.
The closure last week meant the $300 million-plus project, now working on its final levels and close to completion, avoided the start of Victoria's new COVID-19 rules limiting the workforce to just one-quarter of their normal number on site, but these will apply when work resumes.
According to one of the country's largest builders, the incident shows that even with the new rules in place from Friday, continued operation leaves the industry exposed to risk of cross-contamination by contractors. Last week the Victorian government eased its original ruling to allow some movement of specialised trades between sites.
"That’s where I think the industry could still come undone in this next month if it isn’t careful," said Probuild group managing director Simon Gray.
Mr Gray, in fact, favoured a complete shutdown of construction in Melbourne for this six-week period to get the pandemic under control.
"My view was to shut the industry and we would then get on top of this," he said. "You could have shut and it would have meant that everyone was treated the same."
The pandemic is affecting other large projects. John Holland on Monday said a subcontractor tested positive last week, but declined to identify the affected site. Lendlease has not publicly disclosed infection rates, but industry sources on Monday said over the past six months in Victoria, the total number of infections among the company's direct employees and subcontractors was about 10.
Multiplex last month closed its Premier Tower project site in Melbourne after a dozen workers tested positive for the disease.
Probuild, majority owned by South African construction giant WBHO, operates across a range of sectors, from road infrastructure to commercial construction and is adjusting its operations on each site according to the state and size of project.
On a major site such as Far East Corporation's $2 billion, two-tower West Side Place and Ritz-Carlton hotel on 250 Spencer Street, however, the contractor cut its workforce to 200 from the normal daily figure of 800. Rather than working on the two towers at once, Probuild has focused the reduced workforce on just one.
"We’re catching up on facades, doing internal finishes and fittings to some apartments," Mr Gray said.
"We’re selectively working on those projects at very much reduced capacity."
His personal view for an industry-wide shutdown puts Mr Gray at odds with Master Builders Australia, which represents smaller builders, but also with the Australian Constructors Association, a lobby group for larger builders of which Probuild is a member.
The majority of ACA members worked on civil infrastructure work, which was less affected by the state's recent restrictions, and the organisation reflected that, Mr Gray said.
"Their agenda isn’t necessarily the same as what our agenda is," he said. "They’re facing different challenges."
ACA chief executive Jon Davies said every project was different and subject to different restrictions.
"For some projects it will not be practical or economic to continue operating under level four restrictions but for many projects, particularly in the civil infrastructure sector, it will be possible and might actually be necessary to avoid detrimental impacts that can occur when work is stopped during critical activities," he said.
Mr Gray said his company, like many others, had stood workers down.
"The vast majority of projects are radically reduced in overall numbers," he said.
"We’ve had to put off a couple of hundred people, stood them down – both staff and labour – because we haven’t got the workfronts to be able to operate in all directions."
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CAMBRIDGE, Mass., July 30, 2018 (GLOBE NEWSWIRE) -- Surface Oncology (NASDAQ: SURF), a clinical-stage immuno-oncology company developing next-generation immunotherapies that target the tumor microenvironment, today announced that the U.S. Food and Drug Administration (FDA) has granted orphan drug designation to the company’s lead investigational candidate SRF231 for the treatment of patients with multiple myeloma. SRF231 is a fully human antibody that inhibits the activity of CD47, a protein overexpressed on many types of cancer cells which prevents them from being engulfed and eliminated by macrophages.
“While the potential applications for SRF231 in oncology are quite broad, we are particularly excited about the opportunity to provide benefit to patients with multiple myeloma. We have already demonstrated the ability of our antibody to increase phagocytosis of myeloma cells and to shrink tumors in preclinical models,” said Rob Ross, M.D., chief medical officer of Surface Oncology. “Receiving orphan designation for SRF231 represents an important milestone as we continue to progress the program in the clinic in multiple myeloma and other cancer types.”
The FDA’s Office of Orphan Products Development (OOPD) designates orphan status to drugs and biologics intended for the treatment of rare diseases or conditions that affect fewer than 200,000 people in the United States. The designation provides certain benefits to the drug developer including the potential for seven years of market exclusivity upon FDA approval, prescription drug user fee waivers and tax credits for qualified clinical trials.
SRF231 is currently being evaluated in a multi-center, open-label Phase I trial to assess safety and tolerability in multiple ascending doses with the goal of establishing a recommended dose for further study. Following the dose escalation phase, the company intends to evaluate the safety and efficacy of SRF231 in a targeted set of solid and hematologic malignancies.
SRF231 is a fully human monoclonal antibody therapeutic targeting CD47, a protein overexpressed on many cancer cells which prevents them from being engulfed and eliminated by macrophage mediated phagocytosis. SRF231 preclinical results presented at the 2016 Society for Immunotherapy of Cancer (SITC) and the American Society of Hematology (ASH) meetings demonstrated that SRF231 has potent anti-tumor activity preclinically in several different tumor models and in combination with existing cancer modalities. Importantly, preclinical studies also showed that SRF231 does not induce hemagglutination, an important potential safety advantage.
ABOUT SURFACE ONCOLOGY
Surface Oncology is an immuno-oncology company developing next-generation antibody therapies focused on the tumor microenvironment with lead programs targeting CD47, CD73, CD39 and IL-27. Surface’s novel cancer immunotherapies are designed to achieve a clinically meaningful and sustained anti-tumor response and may be used alone or in combination with other therapies. The company has a pipeline of seven novel immunotherapies and a strategic collaboration with Novartis focused on up to three next-generation cancer immunotherapies. For more information, please visit www.surfaceoncology.com.
Ann Stanesa, Ten Bridge Communications


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Though under-reported in the West, during the past few weeks, Russia has been dealing with some of the worst ethnic rioting seen in the country since the end of the Soviet Union. The catalyst for this situation was the murder on December 5 of Yegor Sviridov, an ethnic Russian soccer fan by another group of Russians from the Northern Caucasus region outside of a match by the club Spartak Moscow, and the subsequent release of the perpetrators by the local police. This sparked a protest by thousands of ethnic Russians outside the gates of the Kremlin on December 11. Egged on by members of nationalist and ultra-right wing groups within their numbers, the protest soon turned into a full-blown riot the elite OMON unit of the national militia struggled to contain.
While most Americans think of Russia as a nation filled exclusively with, well, Russians, it actually is a diverse, multiethnic society made up of dozens of ethnic groups. A vast, multiethnic society living together in peace was one of the big propaganda points touted by the old Soviet Union. But when the Soviet Union broke up into 15 independent nations in 1991, old ethnic tensions began to bubble to the surface. In Russia today, both Russian citizens originally from the old Central Asian republics of the Soviet Union, as well as migrant workers from those now-independent countries today, often find themselves the target of racist attacks – Central Asian workers tend to fill the same role in Russia that migrant Mexican workers do in the United States. Russians from the North Caucasus region in southwestern Russia also face widespread discrimination. The North Caucasus region is home to Chechnya, so the common assumption in Russia is that all North Caucasus residents are terrorists (or potential terrorists) and they tend to be treated accordingly.
Unfortunately in the 16 years since the beginning of the first Chechen War, unrest from Chechnya has spread across the North Caucasus to other Russian republics like Dagestan and Ingushetia, and the conflict has evolved from a struggle by Chechen militants for independence for their homeland into one that has become increasingly wrapped up in an al-Qaeda-style battle to create a fundamentalist Islamic state – all factors that feed the “all North Caucasus people are terrorists” meme within Russia. One reason this Islamic fundamentalism has found fertile ground in the region is the generally lousy living conditions found in the North Caucasus – unemployment is ridiculously high as is the poverty rate, while local officials are horribly corrupt – all problems acknowledged by President Dmitry Medvedev. Unfortunately the Russian government's response hasn't been to encourage development and crackdown on corruption in the region, but rather to give a free hand to brutal local leaders like Chechen President Ramzan Kadyrov in dealing with dissent, a strategy that has succeeded only in creating more (and angrier) dissent.
Corruption also directly led to the recent riots in Moscow; the perpetrators of the fatal attack on Sviridov were released from custody after a bribe was apparently paid to the police. But again, this reality failed to bring about the expected response from Russian officials – namely an investigation into rampant police corruption, but instead brought just more political window dressing: namely a visit by Prime Minister Putin to the grave site of the murdered soccer fan, Sviridov. That and the assignment of Russia's newest superstar to the case – Anna Chapman, who was recently named to the advisory board of the “Young Guard”, a pro-Kremlin youth group, to whom she gave the kind of vague and bland speech you expect from politicians today, case in point: “we must transform the future, starting with ourselves!”
For his part, during a nationally televised address, Putin seemed willing to attack the problem of unauthorized protests within Russia, but his focus quickly shifted from ethnic strife and soccer hooligans to liberal political protests. Perhaps to emphasize the point, on December 31, one of Russia's best-known left-wing politicians, Boris Nemtsov was arrested during one of the “31” protests in Moscow – for the past year, liberal groups have publicly gathered on the 31st day or every month that has one in support of the 31st article of the Russian Constitution, which guarantees the people the right to peacefully assemble. Previously, the small gatherings were quickly broken up by the police, though the October 31 rally was allowed to go on with an official approval from President Medvedev. That wasn't the case for the December 31 protest, which was not only broken up, but saw Nemtsov, a former deputy prime minister not only arrested but also sentenced to 15 days in jail.
Just as Russia chose to react to the allegations of police corruption brought forward by Novorossiisk policeman Alexei Dymovsky by creating “Dymovsky 's law” - a law that didn't punish corrupt officers, but rather those who blew the whistle on them, Russia once again seems intent on applying the wrong remedy to a problem – treating ethnic strife by arresting political critics of the Kremlin.
1 day ago

domain: sociology


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Visit the Carter Caves in Kentucky
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Stormwater Sentries is an online stormwater game that promotes awareness of the environmental impact from stormwater runoff into the Chesapeake Bay. Players take on challenges, complete missions, earn money and work to create a sustainable town designed to reduce stormwater runoff.
Stormwater Sentries was designed to demonstrate the impact our decisions have on our private property to local stream health. The Alliance for the Chesapeake Bay wanted to create a fun and engaging experience to educate the community on how to make wiser environmental decisions that improve water quality in nearby streams, rivers, and the Chesapeake Bay. The game went live on April 10, 2014 and is available on Facebook: Stormwater Sentries.
Simple, easy-to-follow instructions lead you through the world of reducing stormwater pollution. See what new challenges await you. Aquire new items to help in your cleanup efforts. Shop for bigger and better BMPs like rain gardens and stream buffers. And check the town’s water quality as you improve the stormwater runoff.
After you try out the free facebook game, learn about how you can improve your neighborhood’s stormwater runoff in the real world. The Alliance developed a program dedicated to these factors, known as Chesapeake RiverWise Communities, which focuses their efforts on increasing green living throughout the area.


text:
Hailed as ‘Heroes,’ Child Care Workers in Some States Are Denied Vaccine Priority
For months, they’ve been labeled “essential workers,” celebrated for his or her sacrifices and hailed as heroes for his or her function in conserving the nation going in the face of a lethal pandemic. But with vaccinations underway—and an finish to the exhaustion, concern and struggling lastly in sight—early childhood educators in some states have discovered themselves snubbed by the very individuals who as soon as praised them for stepping up in a disaster.
In its really useful vaccination schedule, the Centers for Disease Control and Prevention (CDC) counsel that states vaccinate baby care employees, Ok-12 academics and academic help workers collectively—in Phase 1b, alongside different “frontline essential workers” such as grocery retailer employees, public transit employees, law enforcement officials and firefighters, and other people over the age of 75. This group comes behind solely well being care employees and residents of long-term care amenities.
Yet the suggestions are simply that. Each state will get to ascertain its personal vaccination plan, selecting which teams to prioritize over others. Most have adopted the CDC pointers: 39 states, plus Washington, D.C., have mentioned they’ll vaccinate all educators collectively. (Six states—Florida, Indiana, Maine, Texas, West Virginia and Wisconsin—haven’t but specified when Ok-12 and early childhood educators might be eligible.)
Others have opted to veer from the CDC’s suggestions. This contains no less than 5 states—Kentucky, Ohio, Oklahoma, Utah and Wyoming—whose plans put early childhood educators in a decrease precedence group than their colleagues in Ok-12 colleges.
The response from baby care suppliers, academics and advocates in these 5 states—which collectively comprise greater than 75,000 early childhood educators—is a mixture of indignation, frustration and discouragement. Many are additionally not stunned, saying that whereas they hoped for higher remedy, they’ve realized to count on little from a public that thinks of them not as educated educators, however as mere babysitters.
‘We Deserve a Lot More’
Mandy Young is accustomed to the excellence that’s usually accorded to Ok-12 academics however not early childhood educators. She taught in a public college for a number of years earlier than transitioning to early childhood, and he or she realized rapidly that though she’d made a “lateral move” in her profession, “respect-wise, I took a dip.”
“People will treat me like I’m nothing when I tell them what I do now,” says Young, who’s the administrator at CTK Kids Learning Center in northeast Ohio. “They’ll go, ‘Oh …’ Whereas when I was a kindergarten teacher, they’d be like, ‘Wow! That’s amazing. Here’s a discount.’ … It’s not acceptable. It’s not acceptable at all.”
Young says she has been placing in 12- to 16-hour days because the pandemic started 10 months in the past. Her workers usually work 11-hour days. Her heart by no means shut down. When the governor known as upon baby care suppliers to step up and serve the youngsters of frontline employees, that’s what they did.
“We didn’t stop,” she says. “We didn’t close one single day. My teachers didn’t get time off. There was no staying at home or taking a mental health day. You had to keep going, with a smile on your face behind a fabric mask.”
They did it willingly, however not with out concern or fatigue. They understood their function in this disaster was vital, that to remain open meant dad and mom might proceed to work, medical workers might deal with COVID-19 sufferers and grocery retailer employees might preserve cabinets stocked.
“I personally sat at doors doing temperature checks, putting myself at risk to every single person who came through this building,” Young remembers, exasperated. “I’m a special needs mom. Putting myself at risk puts my children at risk. Our job itself is not heroic. It’s the attitude we bring to this job that makes us heroes.”
Meanwhile, Young notes, many Ok-12 educators in Ohio have continued to show their lessons from house, the place they and their households are secure. So when the Ohio Department of Public Health launched details of Phase 1b vaccination distributions earlier this month and it named “adults/employees in K-12 schools” however excluded any point out of kid care workers, Young was incensed.
“It’s a huge slap in the face to our industry and a huge slap in the face to our professionalism,” says Young. “It’s appalling. We deserve a lot more than we get.”
Many early childhood educators had feared this final result and actively labored to stop it. Kimberly Tice, government director of the Ohio Association for the Education of Young Children, a bunch that helps the early childhood workforce, orchestrated the creation of a professional video in December, in which baby care employees throughout the state urge Ohio Gov. Mike DeWine and his administration to prioritize early childhood educators for the COVID-19 vaccine. Tice and her colleagues additionally wrote letters to state management and public well being officers, imploring them to think about the dangers that baby care employees face daily.
Tice realized on Jan. 13, from an electronic mail she obtained from the Ohio Department of Jobs and Family Services, that early childhood educators had been bumped to a decrease vaccination group.
“It’s frustrating. On the one hand, they’ve heard they are heroes and essential workers,” Tice explains. “And yet when the rubber hits the road and priority for vaccines comes along, they’re forgotten. … This decision just seems to fly in the face of being identified as ‘essential.’”
Tice says she sees the argument for speeding vaccines to Ok-12 academics and workers. Many public colleges stay closed, denying college students not solely in-person instruction, however help companies, meals and grownup care and supervision that a lot of them don’t get in any other case.
“We do understand there is a scarcity of the vaccine, but we believe if you’ve prioritized K-12, those who are teaching children birth to age 5 should be in the same category,” she says, adding that this is, after all, what the CDC recommends.
What’s more, Tice argues, is that unlike their peers in K-12 schools, child care workers often lack access to employment benefits such as paid sick leave and health insurance, both of which would be helpful to fall back on should they contract the virus that has killed 400,000 people in the United States and sickened millions.
Like their peers in Ohio, child care workers and early education proponents in Kentucky began lobbying their state leaders about vaccination schedules almost as soon as an effective vaccine was announced.
On Dec. 17, Bradley Stevenson, executive director of the Child Care Council of Kentucky, sent a letter to Gov. Andy Beshear, appealing to him to include early childhood professionals among all other public educators in vaccination priority. “Child care teachers have risen to the occasion and answered the call,” Stevenson wrote.
When he still hadn’t heard anything three weeks later, he organized an online letter-writing campaign where nearly 800 early childhood educators and families sent emails to the governor, the lieutenant governor and the state’s public health administrator, saying, in part, “As vaccines are being distributed in Kentucky and plans are being created to prioritize groups to receive the vaccine, I am requesting that child care teachers/staff be prioritized with all other public education staff.”
But when eligibility for Phase 1b was announced in Kentucky, the only educators counted among them were K-12 teachers and staff.
“I have talked to so many child care providers who showed up, and their teachers showed up, day after day after day, in the midst of a pandemic, to provide essential services,” Stevenson says. “For them not to get that recognition, it really disappointed me. But I probably should not be surprised or shocked. It’s a respect issue. There’s a devaluation on the profession as a whole. … Prioritizing those educators with K-12 educators would have made a statement about the absolute importance of early care in education.”
A spokesperson from the Utah Department of Public Health provided a statement to EdSurge explaining the agency’s decision to vaccinate K-12 educators first.
“Utah, like all other states, has tried to implement a COVID-19 vaccine plan that does the most good for the most people,” the statement reads. “With limited vaccine doses available, we have had to make difficult decisions about who gets the vaccine and when. … Utah’s K-12 schools have been significantly impacted by COVID-19, and vaccinating teachers will help ensure schools can continue to fulfill the important role they provide in our society.”
‘We Owe It to Them’
Among the states that adhered to the CDC’s recommendations for vaccination distribution are Minnesota and Oregon.
On Jan. 18, Gov. Tim Walz of Minnesota announced a pilot program, beginning this weekend, that would vaccinate 6,000 educators, including 2,000 early childhood educators.
“Educators and child care workers care for the mental and emotional well-being of our children, and we know that child care workers are disproportionately women of color, who have been some of the hardest hit by the pandemic. We owe it to them to support their health and safety,” said Minnesota Lt. Gov. Peggy Flanagan in a statement about the pilot program.
Chad Dunkley, president of the Minnesota Child Care Association and CEO of New Horizon Academy, a network of about 70 child care centers in the state, said he “never questioned” that the state would prioritize early childhood and K-12 educators equally. Still, he and his staff wrote letters outlining what they believed to be the most compelling arguments for vaccinating child care workers early.
In one letter, he wrote: “Teachers have put themselves at risk—when working with children, social distancing is not an option as they need our physical, emotional and intellectual support at this critical age.”
In an interview, Dunkley expounds on what he meant by that: “Younger children get bottle fed. They get their diapers changed. And they need physical contact with adults, [such as] hugs when they fall down. Many early educators can’t physically distance from their students,” he says. “In many ways, child care providers should almost be a higher priority.”
Oregon Gov. Kate Brown chose to include child care staff with other educators in Phase 1b, and Melanie Mesaros, communications director for the Oregon Department of Education’s Early Learning Division, explained the decision in an email: “Child care has remained open throughout the pandemic in Oregon. Providers were asked to follow increased safety and health protocols to serve families and essential workers. Early childhood educators have been taking on greater risks, and it’s important they have access to the vaccine so they can continue their critical support to families.”
Mesaros added that the governor also considered issues of equity when determining vaccination priorities. “The families who have been most impacted are disproportionately families of color and low-income families, with the biggest impacts felt by working mothers. Many child care providers themselves are from the communities that have been most impacted by COVID-19,” nodding to the fact that 40 percent of early childhood educators nationwide are women of color.
Ashley C. Williams, a senior policy analyst at the Center for the Study of Child Care Employment at the University of California, Berkeley, says the states that are decoupling early childhood educators from their K-12 counterparts illustrate not only the “societal dissonance” that exists between the two sectors but also the underlying equity issues rooted in history.
“What is it about this workforce of women that they are expected to shoulder the burden of a pandemic, with their own health and wellbeing and their economic dignity on the line? What is it about this group that continues to be undervalued?” Williams asks. “I think it dials me back to issues of inequity and injustice for the people performing this work. Child care in this country has deep roots of oppression and roots in slavery, the place Black ladies have been caring for white ladies’s kids and having to prioritize these kids’s wants over their very own. That is a deeper dialog and a deeper perspective that we have to have.”
Overall, this pattern amongst some states is “very distressing” and “follows a pattern” of disrespect for the sphere, says Calvin E. Moore Jr., CEO of the Council for Professional Recognition, which oversees the Child Development Associate, essentially the most well known and accepted credential in early childhood schooling.
In Ohio, early childhood educators haven’t given up hope, despite the fact that the state has up to now excluded them from the subsequent part of vaccination distribution.
“We’re still continuing to try to have people raise their voices,” says Tice, the Ohio AEYC director, as a result of if she’s realized something over the past 10 months, it’s that circumstances in the course of the pandemic can shift rapidly.
“What is true today,” she says hopefully, “may change tomorrow.”


The Cisco 9124 is a highly capable access point, built for external and industrial environments.
With a range of options to power the AP, and six antenna ports, this is an AP that has something to offer!
Cisco 9124: Use Cases
The use cases for the Cisco 9124 are probably pretty obvious. This is an industrial grade AP and a highly capable one at that too.
The use of 6 antenna ports makes this ideal for Mesh, where you can have two ports supporting 5GHz Mesh backhaul at the same time as supporting local client serving 2.4GHz and 5GHz on different radios - no contention.
The 9124 comes in two variants, with the internal antenna option being more cost effective in most applications, but the external 9124 supports a range of antennas - for those harder to design for spaces and longer range requirements.
There's a range of options to power the AP too - more on that just below.
- Wi-Fi Predictive Designs
- Wi-Fi Surveys: Overview guide to the various Wi-Fi surveys
- Wi-Fi 6E and 6GHz Explained
- Wi-Fi 6 vs 5G
Cisco 9124: Recommended Antenna
Note that if you use the AIR-ANT2588P3M-N (non SIA) antenna with the 9124 AP, then you’ll only be able to use two of the three available ports, unless you’re happy to deploy a 2x2 (with two of the ports) and a 1x1 (with the single remaining port).
The AIR-ANT2588P4M-NS on the other hand has four ports – allowing you to deploy 2x2 on 2.4GHz and 2x2 on 5GHz at the same time.
- Cisco 9124 Antenna Guide
- Wi-Fi 6
- Wi-Fi Design Technical Requirements
- Wi-Fi Design Business Requirements
9124: Six Antenna Ports
The 9124 has six antenna ports in total – the bottom two will support your 2.4GHz and the top outer two ports the 5GHz. There are also two middle ports which are 5GHz only (not dual band like the other four) and you can add more antennas if you want to make use of these ports.
Question: What is the point of the 9124 having 3 radios, with two 5GHz radios?
The major use case here is mesh: you can use one 5GHz radio for backhaul and the other for local client serving on the 5GHz band – no need to compromise the operation of the AP in any way.
The newer SIA patch antennas provide four antennas with two horizontal and two vertical – which ensures that you can take advantage of mixing the polarity, achieving better send and receive.
All the Other 9124 Ports
There's a range of other ports to consider of course. The images below show these, including the DC power and POE power options:
- The Top 8 Secrets to Great Wi-Fi
- Wi-Fi Phone Dropouts
- RF Tuning: Tuning your Wi-Fi network
- WLAN Surveys
Powering the Cisco 9124
Here’s a quick ready reckoner for the devices you’ll need in order to power the 9124:
The "RGD" variants above are the ruggedised ones, built in a metal case for industrial environments.
Cisco 9124: Summary
This is a great choice for external coverage, with the wide variety of external antennas offering a lot of choice for any industrial sites that have some complex requirements.
The addition of the new Self Identifying Cisco SIA antennas makes life just a little easier, especially when they're installed at height - handy to let that take care of itself (it's the recommended option from Cisco too).
You'll get a lot of throughput on this AP too, which can't be a bad thing :-)


text:
Eugene “Pobelter” Park is a veteran North American player known for his 200 IQ plays. The popular player has been in the pro scene since 2013, when he joined Curse Gaming as a top laner and then Meat Playground as their AP carry. Too young to join the LCS at the time, he returned to Curse Academy until he decided to attend school.
Pobelter was one of the youngest players in the LCS when he joined Evil Geniuses’ North American team in 2014. Despite the interesting distinction, Evil Geniuses didn’t have a good showing that year, finishing in ninth place with a 8-20 record. The Summer Split was slightly better as the team finished 11-17.
A solid performance in the later part of 2014 landed EG a spot in the 2015 LCS Spring Split. Pobelter re-signed with the team, which was rebranded as Winterfox. While playing for the team, he never left the top lane position.
Pobelter joined Counter Logic Gaming soon after for the Summer Split. CLG started the Split strong, ranking fifth by week six. The team clawed its way to second place in the end, then dominated in the playoffs. They became North America’s top seed and qualified for the 2015 World Championship. True to most North American teams, CLG was eliminated in the group stage with a 2-4 record.
Pobelter joined Immortals in 2016, a team that was expected to do quite well in the LCS that year. For six weeks, the team lived up to the hype by going undefeated. Unfortunately, they started to falter as the season continued. Luckily, they found themselves in third by the end of the season after beating Team Liquid in the playoffs. The Summer Split went just as well, with Immortals qualifying for the playoffs. Unfortunately, they didn’t qualify for Worlds that year after being defeated by Cloud9 in the Regional Finals.
Pobelter spent 2017 with Immortals again. They came in 7th place for the Spring Split, but the Summer Split saw a better performance. In fact, they qualified for the World Championship thanks to championship points. Once again, the team was knocked out in the group stage after facing Fnatic.
League of Legends fans were shocked when Immortals weren’t invited into the newly franchised NA LCS for the 2018 season. Pobelter left the team in November 2017, finding a new home with Team Liquid. Liquid didn’t have a good showing that year, leaving Pobelter jumping between NA teams for the next few seasons.
North American fans were shocked when Pobelter wasn’t initially signed to a team for the 2020 season. While FlyQuest definitely underperformed, most League of Legends viewers were constantly impressed with Pobelter’s individual performances throughout the past few years. Pobelter called out North American teams for favoring foreign players over NA talent, even if the foreign players aren’t as strong.
In the middle of the Spring Split, struggling Counter Logic Gaming decided to sign Pobelter in hopes of improving their performance with the talented veteran.

domain: hobby


text:
Slums MAG Staff: Marsha P.
In case you missed it, on March 16th Pink Elephant Radio Introduce Queer Hip-hop to Austin Texas. For the first time in history, the SXSW Music Festival made room for talent with a twist. Out-Hip-Hop artist from all over the country tore up the stage while cheering fans got their life watching their LGBTQ+ brothers and sisters do their “thaaang”.
Some of the performers included Loud and Proud Out Artists like Bugz Gutta, DougTheeSavage, BobbyLytes, and Vockah Redu to name a few. Though the crowd was smaller than some official SX shows, the significance of this first-of-its-kind event was not lost on the performers and attendees. Songs like “A Letter from Bugz” performed by Newport News rapper Bugz Gutta reminded the audience of how much determination and perseverance goes into living in your truth while chasing your dreams.


The effect of Rajamouli’s Baahubali was so huge that even the famous search giant had only queries featuring Baahubali. The latest reports suggest that Google’ most searched query in India on Friday was ‘why Kattappa killed Baahubali’.
Even though the suspense broke just hours after the film’s release, the query continued to be on top of the search engine’s list. The sky-high expectations of the film have ensured collected close 200 crores which are the highest for any Indian film to date.
Rajamouli’s vision and hard work are bearing fruits as the tickets for the film have been sold out for the next three days in most parts of the country. Arka media produces this magnum opus which has music by Keeravani.
- Nandita Swetha’s next enters second schedule
- Poll : What did you think of NTR Mahanayakudu’s trailer ?
- NTR Mahanayakudu’s intense and dramatic trailer raises expectations
- Niharika’s career getting a good push
- Big B donates Rs 2.5 crores to martyrs of Pulwama attack