Chakwera meets Malawi team ahead of economic forum in Switzerland
President Dr Lazarus McCarthy Chakwera has begun preparatory meetings with members of his delegation to the World Economic Forum in Davos, Switzerland, in readiness for a rigorous itinerary of engagements aimed at advancing Malawi’s socioeconomic agenda.
President Chakwera started his day with a briefing from the Chargé d’Affaires at Malawi’s Embassy to Switzerland, Mr. Pacharo Kayira, on the 17 engagements His Excellency will have over the next 72 hours.
President Chakwera is expected to meet President Paul Kagame of Rwanda during this year’s World Economic Forum (WEF) currently being held in Davis Switzerland.
Kagame is one of the shining African leaders of recent times who has managed to pull Rwanda out of the aftermath of the 1984 genocide to a beacon of development.
During their meeting the two leaders are expected to share notes on how best to further grow the economies of the two countries both hit hard by covid-19 pandemic, climate change and the war in Ukraine.
President Chakwera has kicked off his week-long stay in Davos, with a very busy schedule.
He arrived in Switzerland on Saturday and today, Sunday he will be attending the welcome reception along with with First Lady Madam Monica Chakwera.
Tomorrow, Monday, President Dr Chakwera gets into serious business when he attends the shareholder dialogue on building economies in fragile economies.
Speaking on departure on Friday in Lilongwe, President Chakwera said there is a need for countries to discuss and find ways of dealing with challenges the world is currently going through.
The forum will run from 21 to 25 May.
Among other issues, the forum will discuss an equitable and fair global recovery path.
On his way back from Davos, Dr Chakwera will pass through Malabo, in Equatorial Guinea where he will attend the 15th Extraordinary Summit meeting of the African Union on humanitarian matters.
The Malawi leader will also attend the 16th Extraordinary Summit meeting of the African Union on Terrorism and Unconstitutional changes of government from 26 to 28 May.
The first AU summit will consolidate efforts by African leaders to address humanitarian challenges the continent is currently facing and develop resource mobilization strategies to address them.
While the second summit will focus on sustainable solutions to the recent surge in terrorism and unconstitutional changes of government.
The Ministry of Foreign Affairs statement says the President will return home on Sunday 29 May 2022.
Is the Bwana Doctor President also meeting or has met the CEO of the convicted corrupt company SICPA Mr. Phillip Amon to further discuss their corrupt public tender and shares of the bribe money..? This for the deal with MRA facilatated by Mr. Lincoln Bailey and his partner Mr. Rafik Gaffar..?
Mr. Amon and SICPA are conveniently located nearby in Switzerland also..


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8. Benign tumors are named using -oma as
a suffix with the organ name as the root.
eg a benign tumor of smooth muscle
cells is called a leiomyoma .
Confusingly, some types of
malignant also use the -
oma suffix, e.g.
Benign tumor of
the thyroid is
Note the normal-
11. Cancers are classified by the type of
cell that the tumor resembles and is
therefore presumed to be the origin of
the tumor. These types include:
Cancers derived from epithelial cells.
the breast, prostate, lung, pancreas,
12. Malignant neoplasm of epithelial cell
origin derived from any of the three
germ layers called carcinomas – e.g. .
Arising from epidermis of ectodermal
Carcinoma arising from cells of renal
tubules are of mesodermal origin .
Ca derived from cells lyning the
gastrointestinal tract are of
endodermal origin .
– Malignant tumor arise from epithelial
• Adenocarcinoma – malignant tumor
of glandular cells .
• Squamous cell carcinoma –
malignant tumor of squamous cells .
Malignant tumor arising from
(i.e. bone, cartilage, fat, nerve)
develop from cells originating
in mesenchymal cells outside
the bone marrow.
15. Sarcomas –
malignant tumor of
•Angiosarcoma – malignant
tumor of blood vessels .
malignant tumor of skeletal
muscle cells .
16. Malignant tumor
(adenocarcinoma) of the
colon. The cancerous
glands are irregular in
shape and size and do
not resemble the normal
colonic glands. The
malignant glands have
invaded the muscular
layer of the colon
18. Squamous cell carcinoma demonstrates enough differentiation. The
cells are pink and polygonal in shape with intercellular bridges .
However, the neoplastic cells show pleomorphism, with
hyperchromatic nuclei. A mitotic figure is present near the center.
19. This sarcoma has many mitoses. A very large abnormal mitotic figure
is seen at the right.
20. Lymphoma and leukemia: These two
classes of cancer arise from
hematopoietic (blood-forming) cells
that leave the marrow and tend to
mature in the lymph nodes and blood,
Germ cell tumor: Cancers derived
from pluripotent cells, most often
presenting in the testicle or the ovary
(seminoma and dysgerminoma,
21. Seminoma. A, Low magnification shows clear
seminoma cells divided into poorly demarcated
lobules by delicate septa. B, Microscopic examination
reveals large cells with distinct cell borders, pale
nuclei, prominent nucleoli and a sparse lymphocytic
22. SPECIALISED TUMOURS
Collision tumour – Two different
cancers in the same organ which
donot mix with each other .
Mixed tumour of the salivary gland
or pleomorphic adenoma is the term
used to benign tumours having both
epithelial and mesenchymal elements
23. Adenosquamous carcinoma demonstrates blended
adenocarcinoma and squamous cell carcinoma within a single
tumor.Small glandlike structures are seen blending with
sheets of squamous epithelium.
24. This mixed tumor
of the parotid
forming ducts and
myxoid stroma that
25. Teratoma –These tumours are made up
of a mixture of tissue types arising from
totipotent cells derived from the germ
layers –ectoderm , mesoderm ,
Most common sites are ovaries and
Extragonadal sites mainly in the midline
of the body eg . Head and neck region ,
mediastinum , retroperitonium,
26. A, Gross appearance of an opened cystic teratoma of the ovary.
Note the presence of hair, sebaceous material, and tooth. B, A
microscopic view of a similar tumor shows skin,sebaceous
glands, fat cells, and a tract of neural tissue (arrow).
27. Teratoma may be
benign or mature ( mostly
ovarian ) or malignant or
immature ( mostly testicular
28. Blastoma – Blastoma or
embryomas are a group of
malignant tumours which arise
from embryonal or partially
differntiated cells which would
form blastoma of the organs and
tissue during embryogenesis.
29. Tumours occur more frequently in
infants and childrens under 5 yrs
of age eg.
30. Hamartoma – Benign tumour which is
made up of mature but disorganised
cells of tissues indigenous to the
particular organ eg Hamartoma of
lung consist of mature cartilage ,
mature smooth muscles and
Choristoma – Ectopic islands of normal
tissues . This is hetrotopia not a true
37. Liomyosarcoma of the uterus: soft fleshy tumor arising from
The tumor shows bundles of malignant smooth muscle fibres.
Extent to which
resembles to normal cells .
resembling the mature
normal cells of the tissues
of origin .
unspecialised cells .
39. Benign tumours are well differentiated
eg Leiomyoma .
Malignant neoplasms range from well
differentiated to undifferentiated .
Lack of differentiation or anaplasia is
considered a hallmark of malignant
• 1. Pleomorphism refers
variation in size and shape of cell
and nuclei . Thus, cells within the
same tumor are not uniform, but
range from large cells, many times
larger than their neighbors, to
extremely small and primitive
FEATURES OF Lack
41. 2. Abnormal nuclear morphology.
Characteristically the nuclei contain
abundant chromatin and are dark
The nuclei are disproportionately
large for the cell, and the nuclear
cytoplasmic ratio os increased .
42. 3. Nuclear-to-cytoplasm ratio
may approach 1 : 1 instead of
normal 1 : 4 or 1 : 6. The nuclear
shape is often irregular, and the
chromatin is coarsely clumped
and distributed along the nuclear
membrane. Large nucleoli are
usually present in these nuclei .
44. 4 . Mitoses –
Increased mitosis reflect the
higher proliferative activity of
the parenchymal cells.
Malignant and undifferentiated
tumors usually possess large
numbers of mitoses .
45. The presence of mitoses, however,
does not necessarily indicate that a
tumor is malignant or that the tissue
More important feature of malignancy
are atypical, bizarre mitotic figures,
sometimes producing tripolar,
quadripolar, or multipolar forms of
46. Many normal tissues exhibiting
rapid turnover eg.
Bone marrow, have numerous
such as hyperplasias contain
many mitotic figures .
Other conditions of increased mitosis
48. 5. Loss of polarity refers to –
Sheets or large masses of
tumor cells grow in an anarchic,
49. 6 . Other changes --
Formation of tumor giant cells,
some possessing only a single
huge polymorphic nucleus and
others having two or more large,
hyperchromatic nuclei .
50. M / E -
Anaplastic tumor of
the skeletal muscle
with marked cellular
nuclei, and tumor
tumour gaint cell
51. 7. Necrosis - Often the vascular
stroma is scant, and in many
anaplastic tumors, large central
areas undergo ischemic necrosis.
52. Dysplasia is a term that literally
means disordered growth.
Characterized by loss in the
uniformity of the individual cells
as well as a loss in their
architectural orientation .
53. Features of dysplasia
Hyperchromatic nuclei with a
High nuclear-cytoplasmic ratio.
The architecture of the tissue
Mitotic figures are more
abundant than usual .
In dysplastic stratified squamous
epithelium, mitoses are not
confined to the basal layers but
instead may appear at all levels,
including cell surface .
55. Graded as mild, moderate or severe.
Mild , Moderate: usually
Severe: usually progresses to
carcinoma in situ (CIS).
• Next step after CIS invasive
GRADING OF DYSPLASIA
58. When dysplastic changes are
marked and involve the entire
thickness of the epithelium but
remains confined by the
basement membrane, it is
considered a preinvasive
neoplasm or carcinoma in situ
WHAT IS Ca Insitu
59. Once the tumor cells breach
the basement membrane ,
the tumor is said to be
60. Carcinoma in situ. This low – power view shows that the entire
thickness of the epithelium is replaced by atypical dysplastic cells.
The basement membrane is intact. B, A high-power view of another
region shows marked nuclear and cellular pleomorphism, and
numerous mitotic figures extending toward the surface.
62. CIN I Mild dysplasia
CIN I MILD
LOWER 3rd OF
CIN II MODERATE
INVOLVE UP TO
MIDDLE 3rd OF
CIN III SEVERE
UP TO UPPER
66. Neuroectoderm NEVUS Malignant
Renal Epithelium Renal Tubular
R C C
Liver Cell Liver Cell
H C C
T C C
Hydatidiform Mole Choriocarcinoma
70. A small hepatic adenoma,
an uncommon benign
neoplasm, with well-
demarcated border (solid
Mucinous cystadenoma of the ovary
71. A small hepatic adenoma,
an uncommon benign
neoplasm, with well-
demarcated border (solid
Mucinous cystadenoma of the ovary
72. Multiple adenomatous polyps (tubulovillous adenomas) of the cecum
are seen here in a case of familial adenomatous polyposis, a genetic
syndrome in which an abnormal genetic mutation leads to
development of multiple neoplasms in the colon. The genetic
abnormalities present in neoplasms can be inherited or acquired.
78. Cervical squamous cell carcinoma. Note the disorderly growth
of the malignant squamous epithelial cells forming large nests
with pink keratin in the centers.
79. Squamous cell carcinoma demonstrates enough differentiation.
The cells are pink and polygonal In shape . However, the
neoplastic cells show pleomorphism, with hyperchromatic
nuclei. A mitotic figure is present near the center.
84. BCC: Groups of neoplastic
basaloid cells infiltrating the
dermis. The cells at periphery
show palisade. The groups of
cells are surrounded by clear
zone due to fixation artifact (
characteristic for BCC).
BCC: peripheral cells are arranged in
a palisade with artificial artifact in
87. This sarcoma has many mitoses. A very large abnormal mitotic figure
is seen at the right.
88. Here is an osteosarcoma
of bone. The large, bulky
mass arises in the
cortex of the bone and
The osteosarcoma is
composed of spindle
cells. The pink osteoid
formation seen here is
89. This large mass lesion is a
liposarcoma. Common sites are
the retroperitoneum and thigh,
and they occur in middle aged
to older adults. yellowish, like
adipose tissue, and is well-
lipoblasts . .
Pagets ds bone
Acute Myeloid Leukemia
Squamous Carcinoma of
H C C
94. Epidemiologic studies established
the relation of -
Smoking and lung cancer .
Implicated in cancer of the mouth,
pharynx, larynx, esophagus,
pancreas, bladder, and most
significantly about 90% of lung
cancer deaths .
95. High dietary fat and low fiber in the
development of colon cancer.
Alcohol with carcinomas of the
oropharynx , larynx, esophagus and
Alcohol and tobacco together increases
the danger of incurring cancers in
the upper aerodigestive tract.
96. Obesity is associated with
approximately 14% of cancer
deaths in men and 20% in
Racial (possibly hereditary),
Cultural influences to the
occurrence of specific neoplasms.
97. The risk of cervical cancer is
linked to age at first intercourse
and the number of sex partners,
and it is now known that
infection by venereally
contributes to cervical dysplasia
98. Age has an important influence on the
likelihood of being afflicted with cancer.
Most carcinomas occur in the later years
of life (>55 years).
Cancer is the main cause of death among
women aged 40 to 79 and among men
aged 60 to 79;
the decline in deaths after age 80 is due
to the lower number of individuals who
reach this age.
99. Carcinomas, the most common
general category of tumor in
adults, are rare among children.
Acute leukemia and primitive
neoplasms of the central nervous
system are responsible for
approximately 60% of childhood
100. The common neoplasms of
infancy and childhood include
the so-called small round blue
cell tumors such as
Acute leukemias, and
101. CHILDHOOD NEOPLASMS SITE
Blood and marrow
Lymphoblastic leukemia Lymph node and lymphoid
Burkitts lymphoma Lymph node and lymphoid
Neuroblastoma Adrenal medulla
102. What is metastasis
The term metastasis denotes the
development of secondary implants
discontinuous with the primary
104. Lymphatic Spread.
Transport through lymphatics is the
most common pathway for the
initial dissemination of carcinomas
and sarcomas may also use this
105. Retrograde metastasis –
Due to obstruction of the
lymphatics by the tumour cells
the lymph flow is disturbed and
tumour cells spread against the
flow of lymph causing
retrograde metastasis .
106. Ca. of prostate to the
supraclavicular lymph nodes ,
Metasatic deposits from
bronchogenic ca to axillary lymph
107. What is Virchows lymph nodes ?
Nodal metastasis preferentially
to supraclavicular lymph nodes
from cancers of abdominal
organs eg cancer stomach ,
colon and gallbladder.
108. carcinomas in the upper outer the
breast quadrants, disseminate first
to the axillary lymph nodes.
Cancers of the inner quadrants
drain to the nodes along the internal
mammary arteries thereafter
infraclavicular and supraclavicular
The pattern of lymph node
involvement follows the natural routes
of lymphatic drainage.
109. Regional lymph nodes draining the
tumour are invariably involved
producing regional nodal metastasis
Ca of breast to axillary lymph nodes
Ca thyroid to lateral cervical LN.
Bronchogenic ca. to hilar and
paratracheal lymph nodes .
110. Skip metastasis”
Local lymph nodes, may be
bypassed called “skip
metastasis” because of venous
-lymphatic anastomoses or
inflammation or radiation has
obliterated lymphatic .
111. Hematogenous Spread.
Hematogenous spread is typical of
sarcomas but is also seen with
carcinomas. Arteries, with their thicker
walls, are less readily penetrated than
Arterial spread may occur, however,
when tumor cells pass through the
pulmonary capillary beds .
The liver and lungs are most
frequently involved in
because all portal area drainage
flows to the liver and all caval
blood flows to the lungs.
114. Common site of blood borne metastasis –
Liver , Lungs , Brain , Bone , Kidney
Few organs eg Spleen , Heart , Skelatal
muscles donot allow tumour metastasis to
Spleen is unfavourable site due to open
sinusoidal pattern which doesnot allow
tumour cells to metastasise .
Limbs ,head , neck and pelvis drain blood
via vena cava so cancers from these sites
metastasise to lungs.
115. Certain cancers have a propensity for
invasion of veins.
Renal cell carcinoma often invades the
branches of the renal vein and then the
renal vein itself to grow in a snakelike
fashion up the inferior vena cava,
sometimes reaching the right side of
Hepatocellular carcinomas often
penetrate portal and hepatic radicles to
grow within them into the main venous
116. Transcoelomic spread –
a. Carcinoma of stomach seeding both
the ovaries ( Krukenberg tumour)
b. Carcinoma of the ovary spreading to
entire peritoneal cavity without
infiltrating the underlying structures.
c. Pseudomyxoma peritonei is the
gelatenous coating of the
peritoneum from mucin secreting ca.
of ovary or appendix .
117. Small tan tumor nodules seen over the peritoneal surface of the
mesentery (peritoneal spread of carcinoma)
118. d. Ca. of bronchus and breast seeding
to the pleura and pericardium.
Spread along epithelial lined surfaces
a. Through fallopian tube from
endometrium to ovaries vice versa.
b . Through bronchus to alveoli.
c. Through ureters from kidney into
lower urinary tract.
Spread via ceribrospinal fluid.
124. Axillary lymph node with metastatic breast carcinoma. The
subcapsular sinus (top) is distended with tumor cells. Nests of tumor
cells have also invaded the subcapsular cortex
127. EFFECTS OF TUMOURS
I.Local effects: local destruction of
tissues causes loss of function,
ulceration, hemorrhage, obstruction, …
Hormone production: well
differentiated (benign) tumors of
endocrine glands may secrete
hormones, and cause hyperfunction.
128. II. Cancer cachexia: i.e. wasting
and weakness. May be due to
loss of appetite, and production
of TNF-alpha (cachectin) and
possibly other factors by tumor
cells and by reactive
129. III –PARANEOPLASTIC SYNDROMES
Symptoms caused by elaboration of
active substances or hormones not
indigenous to the tissue of the origin
of neoplasm. Most common are:
2. Acanthosis nigricans
3. Hypertrophic osteoarthropathy
4. Thrombotic diatheses
131. Cushing‟s syndrome – caused by
small cell (oat cell) bronchogenic
carcinoma --> ACTH.
Hypercalcemia - Caused due to
parathyroid hormone secretion by
bronchogenic squamous cell
carcinoma, (and by T-cell
132. 2. Acanthosis nigricans: a verrucous
pigmented lesion of the skin .
3. Clubbing of the fingers and
associated with lung cancer, and
regress after resection of the
4.Haematological - Thromombo-
plastic substances by tumor cells can
cause DIC or nonbacterial thrombotic
133. Grade Definition
I Well differentiated
II Moderately differentiated
III Poorly differentiated
IV Nearly anaplastic
Grading of Malignant
134. Staging of Malignant Neoplasms
Tis In situ, non-invasive (confined to epithelium)
T1 Small, minimally invasive within primary organ site
T2 Larger, more invasive within the primary organ site
T3 Larger and/or invasive beyond margins of primary
T4 Very large and/or very invasive, spread to adjacent
N0 No lymph node involvement
N1 Regional lymph node involvement
N2 Extensive regional lymph node involvement
N3 More distant lymph node involvement
M0 No distant metastases
M1 Distant metastases present
136. GRADING OF TUMOURS
. Grading is based on the degree
of differentiation and the
number of mitotic figures in the
137. Tumors are classified as Grades I
to IV with increasing anaplasia.
High grade tumors are generally
more aggressive than low grade
The grade of tumor may change
as the tumor grows (with tumor
progression), and different parts
of the same tumor may show
different degrees of differentiation
138. STAGING OF CANCER
Staging is based on the size of the
primary tumor and the extent of
local and distant spread. Staging
proved to be of more clinical value
139. Two methods of staging are
1.The TNM (Tumor, Node,
2.The AJC (American Joint
Both systems assign to higher
stages those tumors that are larger,
locally invasive and metastatic.
141. . 1 . Histologic examination (paraffin-
embedded fixed sections, stained by
. 2 . Cytologic smears (Papanicolaou):
examination of already shed cancer
cells in body secretions.
3 . Fine-needle aspiration: cytologic
examination of aspirated tumor cells
from palpable masses .
METHODS OF DIAGNOSIS OF CANCER
142. 4 . IMMUNOCYTOCHEMISTRY
. Detection of surface markers or
cell products by monoclonal
It can be used for detection of
cytokeratin, vimentin, desmin,
calcitonin, neuron-specific enolase,
prostate specific antigen, products
of tumor suppressor genes (p53),
and oncogenes (c-erb B2), etc ...
143. Gastric adenocarcinoma is positive for cytokeratin,
with brown-red reaction product in the neoplastic cell
cytoplasm . This is a typical staining reaction for
carcinomas and helps to distinguish carcinomas from
sarcomas and lymphomas.
144. This sarcoma is positive for vimentin by
immunohistochemical staining. This is a typical
immunohistochemical staining reaction for sarcomas.
145. A: Normal smear
of the uterine
nuclei with the
mitosis in one cell
146. DNA ANALYSIS (MOLECULAR DIAGNOSIS)
1.DNA Probe Analysis: used for detection of
oncogenes; such as N-myc, bcr-c-abl gene products.
2.Flow Cytometry: a measurement of DNA content of
tumor cells (degree of ploidy).
They are of value to support the
To determine the response to
To indicate relapse during follow-
HCG (trophoblastic tumors and non-
seminomatous testicular tumors)
Calcitonin (medullary carcinoma of
Catecholamin & metabolites
(pheochromocytoma & related
Ectopic hormones (paraneoplastic
EXAMPLES OF TUMOUR MARKERS
MOLECULAR BASIS OF CANCER
Cancer is a genetic disease.
The genetic injury may be inherited
in the germ-line, or it may be
acquired in somatic cells.
. Tumors are monoclonal
(the progeny of a single
genetically-altered progenitor cell).
152. Carcinogenesis or oncogenesis
Carcinogenesis or oncogenesis
means mechanism of induction of
The literature on the molecular
basis of cancer continues to
proliferate at such a rapid pace that
it is easy to get lost in the growing
forest of information.
154. Carcinogens – substances known to
cause cancer or produces an increase in
incidence of cancer in animals or
Cause of most cancers is unknown
Most cancers are probably multifactorial in
Known carcinogenic agents constitute a
small percentage of cases
Unidentified „environmental‟ agents
probably play a role in 95% of cancers
155. Carcinogenesis is caused by mutation
of the genetic material of normal
More than one mutation is necessary
This results in uncontrolled cell
devision and the evolution of those
cells by natural selection in the body.
156. Mutations of genes play vital
roles in cell division,
Mutation of gene regulating
apoptosis (cell death), and DNA
repair will cause a cell to lose
control of its cell proliferation
Cancer is fundamentally a
disease of disregulation of tissue
157. Large-scale mutations involve the
Deletion or gain of a portion of a
occurs when a cell gains many
copies (often 20 or more) .
158. Chromosomal alterations that result
in increased number of copies of a
gene is found in some solid tumors
Neuroblastoma with n-MYC HSR
ERB – B in breast and ovarian
159. Translocation eg -
Philadelphia chromosome -
translocation of chromosomes
9 and 22, which occurs in chronic
myelogenous leukemia, and
results in production of the
BCR – abl fusion protein, an
oncogenic tyrosine kinase .
160. The Philadelphia chromosome,
characteristic of CML provides the
prototypic example of an oncogene
formed by fusion of two separate genes.
In Reciprocal translocation between
chromosomes 9 and 22 relocates a
truncated portion of the proto-oncogene
c-ABL (from chromosome 9) to the BCR
( breakpoint cluster region ) on
163. Point mutation of RAS family genes is
the single most common abnormality
of proto-oncogenes in human tumors.
Approximately 15% to 20% of all
human tumors contain mutated
versions of RAS proteins. Eg.
pancreatic adenoca , cholangioca ,
myeloid leukemia , lung ca, contain a
RAS point mutation .
165. Carcinogenesis is a multi-step process.
Characteristic features of malignant
Excessive rate of growth,
Escape from the host immune
acquired in a stepwise series of
genetic events, a process called
166. Four classes of regulatory genes.
1. Promotors – Proto-oncogenes
2. Inhibitors – Cancer-suppressor
genes – p53
3. Genes regulating Apoptosis.
4. DNA repair genes.
167. Genetic alterations may involve:
1. Growth-promoting proto-
oncogenes (activation of growth-
2. Growth-inhibiting tumor-
suppressor genes (inactivation of genes
that normally suppress cell proliferation,
“tumor suppressor genes”)
3. Apoptosis-regulating genes
(genes that prevent programmed cell
170. MULTISTEP CARCINOGENESIS
Chemical carcinogen reacts with DNA to
produce a mutation.
Involves carcinogen metabolism, DNA
repair & cell proliferation.
Initiation is irreversible but an initiated cell
is not a cancer cell and does not necessarily
171. MULTISTEP CARCINOGENESIS
Tumor promotors contribute to
carcinogenesis by nongenotoxic mechanisms.
Influence proliferation of initiated cells to form
benign lesions which may regress or acquire
additional mutations to become a malignant
173. MULTISTEP CARCINOGENESIS
Tumors acquire ability to invade and establish
Characterized by chromosome instability and
mutations in oncogenes and tumor suppressor
Mutations may reflect selection of cells suited for
neoplastic growth and may in turn increase
183. A virus that can cause cancer is
called an oncovirus. These include
Human papillomavirus (cervical
Epstein-Barr virus (B-cell
lymphoproliferative disease and
184. Kaposi's sarcoma herpesvirus
(Kaposi's Sarcoma and primary
hepatitis B and hepatitis C viruses
(hepatocellular carcinoma), and
Human T-cell leukemia virus-1 (T-
185. Bacterial infection may also increase
the risk of cancer eg.
Helicobacter pylori-induced gastric
Parasitic infections strongly
associated with cancer include -:
Schistosoma haematobium (squamous
cell carcinoma of the bladder) and the
liver flukes, Opisthorchis viverrini and
186. RADIATION CARCINOGENESIS
Radiant energy, whether in the form of the
UV rays of sunlight or as ionizing
electromagnetic and particulate radiation,
can transform virtually all cell types in vitro
and induce neoplasms .
UV light is clearly implicated in the causation
of skin cancers .
Ionizing radiation exposure from medical or
occupational exposure, nuclear plant
accidents, and atomic bomb detonations have
produced a variety of forms of malignant
187. Sources of ionizing radiation include
medical imaging, and radon gas. non-
ionizing radiation from ultraviolet
radiation leukemias typically require
2–10 years to appear.
Some people, such as those with nevoid
basal cell carcinoma syndrome or
retinoblastoma, are more susceptible than
average to developing cancer from

domain: medical


text: Catharanthus roseus synthesizes a wide range of valuable monoterpene indole alkaloids, some of which have recently been recognized as functioning in plant defence mechanisms. More specifically, in aerial organ epidermal cells, vacuole-accumulated strictosidine displays a dual fate, being either the precursor of all monoterpene indole alkaloids after export from the vacuole, or the substrate for a defence mechanism based on the massive protein cross-linking, which occurs subsequent to organelle membrane disruption during biotic attacks. Such a mechanism relies on a physical separation between the vacuolar strictosidine-synthesizing enzyme and the nucleus-targeted enzyme catalyzing its activation through deglucosylation. In the present study, we carried out the spatial characterization of this mechanism by a cellular and subcellular study of three enzymes catalyzing the synthesis of the two strictosidine precursors (i.e. tryptamine and secologanin). Using RNA in situ hybridization, we demonstrated that loganic acid O-methyltransferase transcript, catalysing the penultimate step of secologanin synthesis, is specifically localized in the epidermis. A combination of green fluorescent protein imaging, bimolecular fluorescence complementation assays and yeast two-hybrid analysis enabled us to establish that both loganic acid O-methyltransferase and the tryptamine-producing enzyme, tryptophan decarboxylase, form homodimers in the cytosol, thereby preventing their passive diffusion to the nucleus. We also showed that the cytochrome P450 secologanin synthase is anchored to the endoplasmic reticulum via a N-terminal helix, thus allowing the production of secologanin on the cytosolic side of the endoplasmic reticulum membrane. Consequently, secologanin and tryptamine must be transported to the vacuole to achieve strictosidine biosynthesis, demonstrating the importance of trans-tonoplast translocation events during these metabolic processes.

domain: biology


text:
In addition to acne scars, INFINI may be used to treat other skin problems
Stretch marks are red or purple narrow streaks (or lines) that appear on the surface of the skin. They usually appear on the abdomen, buttocks, breasts, and thighs. They may form during sudden changes in body size, such as during pregnancy, puberty, or rapid weight-gain or loss. The appearance of stretch marks can be improved by using INFINI in the same way that other skin indications are treated.
Enlarged pores result from genetic and environmental factors. Aging, decreased skin elasticity, overexposure to sunlight, and acne of all types are the main contributors to enlarged pores. To mitigate acne scarring and enlarged pores, INFINI precisely targets specific layers in the skin to create narrow and robust coagulation zones and to stimulate collagen regeneration and the body’s natural healing process.
As we age, skin changes and begins to wrinkle. Our skin forms fine lines, becomes dry, and decreases collagen production. INFINI can help restore the vitality and youthfulness of your skin by stimulating skin cells to produce collagen and support the body’s natural healing process.
A result of the natural loss of collagen, overexposure to sunlight, changes in hormonal balances, and the natural contraction of facial muscles when laughing or frowning. INFINI can reduce these wrinkles by stimulating collagen production and restoring the skin’s youthful look.
Simply the technical term for excess sweating and hyperhidrosis may cause a lot of embarrassment in social circles. Although neurologic, endocrine, infectious, and other systemic diseases can sometimes cause hyperhidrosis. No one cause has been determined to cause hyperhidrosis. When INFINI targets specific layers in the dermis to create controllable and robust coagulation zones, it contracts pores. That, in itself, helps limit excessive sweating in the targeted areas.
Excessive sebum secretion commonly happens with those with oily skin because of the hyperactivity in the sebaceous glands. The true cause of that secretion is a genetic one – an excess of a hormone called dihydrotestosterone (DHT). That hormone is responsible for triggering sebaceous glands to produce sebum. INFINI effectively reduces sebum production by generating heat that deactivates the sebaceous glands and thus reduces sebum production in the skin.


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Our Cars: MPG meets MPH
for more details).
2007-3 (17 January 2007) (p. 79)
for more stories from this issue).
Steve Sutcliffe loves the D3's blend of frugality and performance
It's difficult to overstress how much I like 'my' new ALPINA D3. I say 'my' because I've become really quite attached to it of late.
Silver D3 Saloon reg: FJ56 CKC
Alpina D3 - (e90 (06 - ))

domain: hobby


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Get ahead in FIFA with ease by obtaining free coins and points without spending a dime. No need to struggle while playing, thanks to the availability of our FIFA coin generator. Play on while having all the in-game currency you need, without any restrictions on the amount you can generate. FIFA 23 hack will keep your account growing, even when you’re not playing. Use this special tool to top up your resources and experience limitless gaming fun.
How Much Real Money Would You Need to Spend to Get 500,000 Coins on FIFA?
It’s not just that people spend money at the store to buy FIFA Points, many also spend their own cash on packs. You can buy a bundle of 12,000 FIFA Points for £79.99/$99.99.
This will allow you to buy 80 Premium Gold Packs, but usually it is best to wait for Promo Packs to appear in the store and purchase them with FIFA Points.
Converting a single pack of Premium Gold into coins is random, but you could get at least 1300 coins if you sell it. At a rate of 2,500 coins per pack on average, 80 Premium Gold Packs provide you with 240,000 coins. Therefore, you would need to buy 500 batches of 12,000 FIFA Points to get 100 million coins. A lot of money would be required to purchase all the best players in football.
How Long Would it Take to Earn 500,000 Coins Through Trading?
Trading is one of the best ways to make coins in FIFA, but it also requires a lot of hours spent both buying & selling players or items on the transfer market. Many FIFA traders have made tens of millions of coins with their speculation and if they invest well they can make even more.
Even if you are a successful trader, it can still take you a long time to earn 100m coins. For instance, if you make around 50k in trading every hour, it will take 2k hours to reach that goal.
If you trade for 10 hours a day at this sort of profit, it will take you about 200 days to be able to afford the Ultimate Team.
Our Impressions About FIFA 23
The FIFA series, including recent games like FIFA 23 or FIFA 22, has been around for over 20 years and remains the most popular soccer game. A large part of the game’s success has come from the exclusive FIFA license that has given EA Sports access to real players’ names, unique stadiums and other things like clubs jersey colors.
FIFA Points and FUT Coins are two kinds of currencies available for you to purchase packs, buy players from the transfer market and generally improve your squad in the Ultimate Team game mode in FIFA games. FIFA Points are a premium currency that can be used within the FIFA 23 Ultimate Team mode. They can be used to buy packs and draft entries from the in-game store. Players can earn coins, which are used as the in-game currency, too. You can get them by completing objectives or selling players, and they’re spent on unlocking new content or buying packs.
Ultimate Team is a game mode in FIFA which allows you to create the dream team of your choice by selecting any player from the world’s best team. That includes Lionel Messi and Cristiano Ronaldo! With their hefty price tags, these players will be sadly out of the reach for most people. But not to worry, there are other ways to acquire such a player- you can build your own dream team with those players you have and trade them with your friends.
There are a few ways to make coins in FIFA , including playing matches, trading on the transfer market and spending real money to buy packs. But how much does the best team in the game actually cost? FIFA Ultimate Team has a player market of real world money being traded and it is quite easy to purchase players for 100 million in-game coins.
Obviously, depending on your playing style and preferences, you’re going to choose a different team of players. The highest-rated players are obviously Icon Pele and Icon Diego Maradona. Some players in the game, such as Ronaldo and Paolo Maldini, cost over 10 million coins each across the PlayStation, Xbox, and PC markets. Others cost over 7 million coins like Harry Kane in the PlayStation or Xbox markets while they can cost over 11.5 million coins on PC markets.
About FIFA 23 Event and Prizes
FIFA 23 is a football simulation video game developed by EA Sports. It has been popular in all parts of the world for a long time. The game is free that can be played on all devices – smartphones, tablets and consoles. Main advantage of the game is very realistic graphics which makes you feel you are playing the real football matches. What makes this game so interesting is variety of options – you can make your own team of superstars, you can play against other players online and take part in many tournaments and leagues. Live events are specially loved among players, because it let you participate in real – world events and challenges. Also, there is a way to upgrade and improve your team’s overall performance – just collect and trade cards.
Some of the leagues and tournaments you can take part in are:
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- La Liga
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- UEFA Champions League
- FIFA World Cup
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Live events are great because you compete with other players in real-time and you can earn valuable prizes which are very helpful for further gameplay. Some of them are:
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- Squad Building Challenges
- Special Matches
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domain: game


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We’ve got plenty of Breeders’ Cup picks and handicapping information lined up for the big races on Saturday, starting with one of our expert capper’s favorite races!
Marshall Posner joined the Pick Sixty team this summer and he’ll be contributing plenty of NFL and NHL wisdom in the months ahead but MP’s true expertise is at the track, where he has nearly 30 years of handicapping experience. If you have any questions about this horse racing article don’t hesitate to contact Marshall on Twitter.
BREEDERS’ CUP PICKS
The Turf is one my favourite races on the BC card and I’m going straight to the Euros here. Even with some of Europe’s best turfers absent, the American runners don’t have much chance in this race. My favourite horse is #1 Telescope – he’s been pointed at this race since the summer and he comes in fresh. His jockey has won this race three of the past six runnings and his trainer has won this race three times so the connections are solid. His last race was excellent behind Europe’s top horses in Australia and The Grey Gatsby. The latter came back to win his next out start as well. There aren’t any horses that compare to those two in this race. I like the post position for Telescope also because it’s a weird configuration fat 1 ½ on the turf at Santa and the outside horses will be wide running into a sweeping turn right out of the gate. Telescope will get a ground saving, rail hugging journey. He likes the distance with two wins from three and his been first or second nine of 10 times. His Racing Post Ratings convert to 111 and 112 at the distance which is higher than the Beyer par. Telescope will likely be the second choice on the board with odds of about 3-1.
Based on his second in the l’Arc de Triomphe, the likely fave is #7 Flintshire. He certainly has the class to win this race but I think he’s more likely to see a regression from that top Beyer last out as opposed to a progression. The Arc is often referred to as the most grueling race in the world so I’m going to play against this Euro on top. I do, however, think he can definitely get second or third.
The other Euro to consider is #4 Brown Panther. From looking at his past performances you almost get the feeling he wants to go even longer than a 1 ½ miles and he actually has several races at 2 miles or longer. From watching his replays you can see that he’s a massive animal so it’s no surprise he’s five for seven at the distance. I’m not sure how he’ll react to the tight turns at Santa Anita; he may have trouble navigating the course. His best races seem to be a cut below Telescope but if he takes to the course he could be tough. His morning line odds of 8-1 are also quite appealing. I’ll definitely use him underneath my top choice, Telescope.
Main Sequence might be a popular play because he’s won three in a row since coming to the States but he’s been beating up on American 12 furlong horses, which aren’t known for their quality. The wins haven’t come by a healthy margin either, which I’d expect from a top turfer. I’m going to use him in some triactors for third.
The final Euro to mention is the filly #11 Chiquita. She was actually the favourite in the Arc race but finished near the back of the pack so you know she has talent. She then raced back on Oct. 18th in Britain and drifted in the lane to lose the race. I think it’s asking a lot of her to show up in this race. Considering she’s winless in 2014 I’m not going to use her at all.
THE BOTTOM LINE
I’m going to bet Telescope to win at 3-1 or better and I’ll single him in my multi-race wagers. I’ll also bet an exactor box with #4 and #7 and use them both in a couple of triactors with all for 3rd.


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The UK Supreme Court will rule this week on the validity of two Scottish Parliament bills attempting to incorporate international treaties into Scots law.
Judgment will be given on Wednesday on whether the Parliament was acting within its powers when it passed the United Nations Convention of the Rights of the Child (UNCRC) (Incorporation) (Scotland) Bill, and the European Charter for Local Self Government (Incorporation) (Scotland) Bill. The Advocate General for Scotland and the Attorney General referred the bills for a ruling, claiming that by giving the Scottish courts extensive powers to interpret and scrutinise primary legislation passed by the UK Parliament, the bills modify s 28(7) of the Scotland Act 1998 and are therefore outside the legislative competence of the Scottish Parliament.
A further issue is whether the bills can be “read down” – read in such a way that they come within legislative competence, in terms of s 101(2) of the Scotland Act.
It has been claimed that the Scottish Government ignored suggestions from the UK Government as to how the bills could be worded so as to avoid a challenge.

domain: news


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Google's effort to revamp its mapping system took an eerie turn when one of its camera trucks captured what looked like suspicious behavior in Detroit.
In September 2009, Google's camera snapped photos of a man with a gun standing on the porch of the house that is said to be where a 17-month-old was found dead last summer.
The photo shows a shirtless man pointing a gun at the street. There are four other people behind him, all gazing toward the camera.
All parties on the porch look young, perhaps in their teens. The series of photos shows how they all turn to look at the Google truck as it passes by.
A meteorologist from Maryland, Jacob Wykoff, who stumbled upon the photo on Reddit, told ABC News that he found it frightening.
"Anytime you see a gun pointed at a cameraman it gets kinda scary," he said. "Detroit kind of has a reputation nowadays for doing that kind of stuff. It wasn't that out of the ordinary."
Habitual or not, the death of the 17-month-old child still strikes a chord in the Detroit population. Police say it hasn't been determined exactly how she died, and no one has been charged in her death.
People have been speaking up on the DetroitYes forum, saying this is the house where Zyia Turner, the the young child, last June.
One person commenting had compared each house with that in the Google image and found that the photo and the alleged crime scene matched.
"Noticed some similarities. Same cream-colored brick, same tapered shape to the brick columns, same green Astroturf glued to the porch, same wrought-iron security door, same gutter security camera and the same neighbor's fence."
Wayne County prosecutor Kym Worthy told CBS Detroit, though, that this photo was not enough to seal the case, and that many questions still remained.
"Was it this person's home? Because you do have a right to bear arms in your home," Worthy told CBS Detroit. "Certainly, it looks like he's on a porch that's attached to a home, so that would not be a legal issue."


By FP News Service
Barnagar is on way to self-reliance as Covid rages through Ujjain district.
Barnagar: Due to the spike in Covid-19 cases in rural areas apart from the urban areas, tehsildar Suresh Nagar through a press note on We...Read More
Barnagar: People are contributing for the 52 bedded Covid Centre located at the Hazaribagh Bus Stand in Barnagar under Atmanirbhar Barnag...Read More
At Chikli procurement centre, the team found that a truck of wheat was rejected on April 11 by surveyor in Ingoria. The same wheat was l...Read More
BARNAGAR (UJJAIN DISTRICT): Situation in Barnagar village of Ujjain once again turned critical after 31 new corona cases were reported in...Read More
New wheat procurement centres have been set up at Asawata, Gunawad, Pir-Hajaylar, Baledi and Ghadsiga, which will save farmers’ travel co...Read More
A case was registered against accused who was presented in court. The court has sent accused to 14-day judicial remand.
BJP government's achievements in the past year highlighted in press conference in Barnagar
Vaccination centres have been established at 58 places in the district.
By FPJ News Service
Ujjain: A 15-year-old boy was assaulted to death while he was having food after his day long roza in Barnagar on Sunday. According to pol...Read More
Ujjain: A police constable was killed on the spot in a road mishap near Barnagar on Thursday night.Victim identified as Rahul Chouhan of ...Read More
By FPJ Bureau
Ujjain: Amid unruly scenes, voters of seven Assembly seats of Ujjain district— Barnagar, Nagda- Khacharod, Mehidpur, Ghatiya, Tarana, Ujj...Read More
About 500 BJP workers from Barnagar resorted to aggressive dharna in front of the Lokshakti Bhavan located divisional headquarters of BJP...Read More
Ujjain: Students of Jain Public School (JPS), Barnagar, run by Jain Group of Institutes, Bengaluru, have scaled the heights of success by...Read More
Ujjain: Jain Public School, Barnagar organised an investiture ceremony for the academic session 2017-18 with great pomp and show. The ev...Read More
Ujjain: State Bodybuilding Association organised a ‘gym sammelan’ on Monday. More than 123 coaches and directors of 80 gymnasiums from Uj...Read More
By Staff Reporter
Indore : Booking for summer special bi-weekly Indore-Delhi (Sarai Rohilla) will start from Saturday.
Ujjain: A teacher who had raped a 7-year-old student at a school in Aslawada village near Barnagar on Gandhi Jayanti last year was senten...Read More
Ujjain: Bike thieves targeted four two-wheelers in the city while two bikes were stolen from Barnagar and Nagda in different incidents on...Read More
Ujjain: Jain Toddlers, Barnagar hosted the 3rd annual sports meet at Jain Public School, Barnagar amidst full zeal and enthusiasm. The to...Read More


Download Dance Dance Revolution Extreme - Premium CD soundtracks to your PC in MP3 format. Free Dance Dance Revolution Extreme - Premium CD soundtracks, Dance Dance Download, Search and Listen to over 30 million music and mp3 files from the web free at Musicdumper.com A brand new version of the classic Moby track, recorded as the official theme music for the fourth Bourne movie 'The Bourne Legacy', in cinemas August 2012 Download Extreme Karaoke 3.0 Download - real advice. eXtreme Karaoke and 4 more programs. HD Tamil Video Songs & Trailers 2015 Tamil Mp3 Songs 2014 Tamil Mp3 Songs 2013 Tamil Mp3 Songs 2012 Tamil Mp3 Songs 2011 Tamil Mp3 Songs 2010 Tamil Mp3 Songs 2009 Stream your favourite hindi songs for free online. No need to download, create your playlist & listen to old, new, latest Bollywood music anywhere, anytime! Final Fantasy Enthusiast Site Featuring Forums, Ringtones, Guides, Walkthroughs, Wallpaper, Mp3s, Midis, Videos, and General Information for Final Fantasy, Kingdom WWE Extreme Rules 2014 Paige vs. Tamina Snuka Divas Championship Match Editor: EddySpeeding Theme Song´s: - "The Fury" by X-Ray Dog Facebook Page: https 2015 Tamil Mp3 Songs Download | Kaththi Mp3 Songs | Free Tamil Mp3 Songs | Free Tamil Downloads Tech/Extreme Prog Metal definition This category lists technical Progressive Metal bands that have roots in Extreme Metal or that are strongly influenced by it.


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PHINDA PRIVATE GAME RESERVE
Nestled in the lush KwaZulu-Natal region of South Africa you’ll find the exclusive Phinda Private Game Reserve. Located within a World Heritage Site, the Game Reserve comprises 14 000 hectares of prime conservation land.
There are 6 Lodges available in Phinda Private Game Reserve; FOREST LODGE, MOUNTAIN LODGE, VLEI LODGE, ROCK LODGE,
ZUKA LODGE & THE HOMESTEAD
Accommodation includes upscale suites, uniquely decorated to mirror the picturesque surrounds. Each air conditioned suite provides serene, reflective spaces to watch the secrets of the forest unfold & the sweeping view of one of the most unique ecosystems in the world.
Guests are invited to take part in any of the Phinda Adventures on offer; including Zulu village tours, Maputaland beach adventures, night turtle drives (seasonal), scuba safaris, ocean safaris, Black Rhino tracking on foot, and visits to an endangered Wild Cats project. Seven distinct habitats are home to an abundance of amazing and unique wildlife including Africa’s Big Five and over 380 bird species.

domain: geography


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1 x Sheet Of Shortcrust Pastry
2 x Large Heirloom Tomatoes (Red & Orange) Thinly Sliced. Note: If you cant find those tomatoes, Salad Tomatoes Is Fine.
1/2 Punnet Of Grape Or Cherry Tomatoes, Halved.
2 x Green Zucchini’s, Sliced.
4 x Cloves Black Garlic, Sliced. Note: Black Garlic Can be Found In Specialty Grocery Stores.
1 x Thin Block Greek Fetta, Crumbled
6 x Sprigs Fresh Thyme. Leaves Removed
Salt & Pepper
1. Preheat Oven To 200°c. Baking Tray, Place Baking Paper. Place Sheet Of Short Crust Pastry On Tray. With a Fork, Pierce Pastry, Brush Lightly With Oil
2. In a Bowl, Place Tomatoes, Zucchini, Thyme, Black Garlic, 2 Tbsp Olive Oil, Season w/ Salt & Pepper. Mix & Coat Well.
3. Place Ingredients in Centre Of Pastry, Allowing About 2cm Clear, All Around The Pastry To Fold. Sprinkle With Crumbled Fetta.
4. Fold In The Pasty As Seen On Photo All Around. Brush With Oil. Place In Oven For About 20 – 25 Minutes or Until Pasty Is Golden Brown. Serve.
10 Chicken Wings
2 Tbsp Vegeta Gourmet Stock
1 1/2 Lemons Juiced
3 Cloves Smoked Garlic, crushed
4 Tbsp Oregano Oil
1. In a bowl place all ingredients except chicken wings and combine well.
2. Place wings with marinade, combine and coat wings well. Place in fridge for 4 hours or overnight.
Note: Dont Have oregano oil? Just grab a bunch of fresh oregano and 1/4 cup olive oil and place ingredients in a bowl and let the oil infuse for a min of 4 hours.

domain: food


Shadow volume BSP trees for computation of shadows in dynamic scenes
AuthorChrysanthou, Yiorgos L.
SourceProceedings of the Symposium on Interactive 3D Graphics
Proceedings of the 1995 Symposium on Interactive 3D Graphics
Google Scholar check
MetadataShow full item record
This paper presents an algorithm for shadow calculation in dynamic polyhedral scenes illuminated by point light sources. It is based on a modification of Shadow Volume Binary Space Partition trees, to allow these be constructed from the original scene polygons in arbitrary order and to support for fast reconstruction after a change in scene geometry. Timings using sample scenes are presented that indicate substantial savings both in terms of computation time and shadows produced.


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Spanish bloggers could face up to two years in jail for organizing street protests, according to draconian new laws proposed by the country's interior minister.
Jorge Fernandez Diaz laid out the measures in parliament on Thursday; they would criminalize those caught organizing street protests that seriously disturb the public peace.
The change to the penal code -- which sets a minimum jail term of two years -- is intended to prevent the sort of violent rioting seen in cities across Spain, notably in Barcelona, where anti-capitalist groups are accused of stirring tensions during last month's general strike.
According to Diaz, ''serious disturbances of public order and intent to organize violent demonstrations through social networking'' would carry the same penalties as being involved in a criminal organization, London's Daily Telegraph reported.
The proposed amendment has raised fears the government could stifle further protests and has evoked comparisons with Spain's late fascist dictator, Generalissimo Francisco Franco.
Diaz added that the new laws would also give the authorities power to clamp down on the protests themselves, making it an offense to breach authority using mass active or passive resistance against security forces and to include as a crime of assault any threatening or intimidating behavior.
In a statement following Diaz's announcement, the Interior Ministry said: New measures are needed to combat the spiral of violence practiced by 'anti-system' groups using urban guerrilla warfare.
The move echoes growing determination among European governments to punish those who use social media and instant messaging to organize and co-ordinate street protests.
In Britain, the Riots Communities and Victims Panel -- set up to investigate last year's civil unrest -- concluded that social media had a large part to play in organizing and inciting violence.
But rather than advocate clamping down on social media, the panel suggested viral silence may have as many dangers as viral noise.

domain: sociology


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a physicochemical property of soil functionally related to the concentration of H+ and OH- ions in the solid and liquid parts of the soil. If H+ ions are predominant, the soil reaction is acid; if OH- ions are predominant, it is alkaline. If the concentrations are equal, the soil reaction is neutral. The pH of soils in the USSR varies from 4 to 8.2.
The soil reaction plays an important part in the migration of products of weathering. The migration capacity of Fe, Mn, Sr, and Cu compounds increases in an acid medium, while that of Si and Al compounds increases in an alkaline medium. The soil reaction greatly affects the metabolic level of plants. Because many plants are harmed by a high concentration of [H+] and [Al3+] ions when the soil reaction is acid, acid soils must be treated with lime. Such strongly alkaline soils as solonetz soils and sodium carbonate solonchak soils, which have a high concentration of [OH-] ions and lack structure, are also unfavorable for plant growth and development.
The application of gypsum combined with organic fertilizers neutralizes an alkaline soil reaction and improves the soil’s agronomic properties. Indicators used to determine the soil reaction quantitatively include the pH of a soil suspension in water or a KC1 solution and titratable acidity or alkalinity.
REFERENCESSerdobol’skii, I. P. “Metody opredeleniia pH i okislitel’no-vosstanovitel’nogo potentsiala pri agrokhimicheskikh issledovaniiakh.” In Agrokhimicheskie metody issledovaniia pochv. Moscow, 1960.
Rode, A. A., and V. N. Smirnov. Pochvovedenie, 2nd ed. Moscow, 1972.
Kovda, V. A. Osnovy ucheniia opochvakh, book 2. Moscow, 1973.
IU. A. POLIAKOV

domain: agronomy


one. What The Truck?!?
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Florida, United States About Podcast Stephen Oatley, a freight field blogger, vlogger, and social media influencer, leads this new podcast & social stay stream — Freight Broker Stay. The written content aims to support teach, coach, and entertain the trucking field on how brokerages and trucking providers can function proficiently and realize accomplishment through news, serious experience, and audience participation. Frequency one post / day Considering the


text: An Inside Look at Retirement Living The slideshow presentation that you would like to view is too large for your current screen resolution. Click here to view to view the slideshow at full resolution. Launch Presentation » Have A Question About This Topic? Name Email Address Question Thank you! Oops! Related Content Where Will Your Retirement Money Come From? Retirement income may come from a variety of sources. Here's an overview of the six main sources. Do Our Biases Affect Our Financial Choices? Even the most seasoned investors have biases affecting their financial choices. Social Security Taxes Estimate how much of your Social Security benefit may be considered taxable.

domain: economics


GKN PLC is a holding company. The Company operates in global automotive, aerospace and land systems markets (including agriculture, construction and mining). The Company�s division includes GKN Driveline, GKN Powder Metallurgy, GKN Aerospace and GKN Land Systems. GKN Aerospace is a supplier of airframe and engine structures, components, assemblies and transparencies to a range of aircraft and engine prime contractors and other first tier suppliers. GKN Driveline is a supplier of automotive driveline systems and solutions. GKN Powder Metallurgy is a manufacturer of sintered components. GKN Land Systems is a supplier of technology differentiated power management solutions and services.


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We are all familiar with the absurd conspiracy theories and outrageous claims being made south of the border by anti-vaxxers and other denizens of the lunatic fringe. Only now they are not so far out on the fringe. When more than 58% of Americans believe that Donald Trump won the November 2020 presidential election, or that Bill Gates is implanting microchips in the Covid vaccine, you know that something is seriously wrong with the body politic.
Americans have always been leery of government, but their congenital lack of trust in politicians has now morphed into a lack of trust in almost all of the major institutions of democracy. Worse still, they have been spurred on by reckless hyperpartisan politicians who happily stoke the flames of discontent by repeating and even creating their own disinformation campaigns. Make no mistake, American democracy is in serious trouble. Stephen Marche’s recent book, The Next Civil War: Dispatches from the American Future, paints a chilling portrait of possible scenarios if this trend is not reversed.
Unfortunately this growing disinformation phenomenon is hardly unique to the United States. Virtually all western liberal democracies have seen an increase in voter discontent fuelled in large measure by their own ignorance. The unexpected success of Boris Johnson’s blatantly misleading pro-Brexit referendum campaign is only one obvious example, and one for which the disastrous results of that pyrrhic victory have been on display ever since. Disinformation campaigns – notably regarding the activities of the European Union or the plight of migrants — have also been used to great effect by extreme opposition parties in France, Italy and Spain, to name just a few other established liberal democracies at risk.
Admittedly this depressing reality has been aided and abetted by hostile covert interventions by foreign actors such as Russia, Iran and China, but these deliberate efforts to subvert the democratic process could only succeed if they fall on fertile ground. The greater threat is coming from within. As Pogo said, “We have seen the enemy and he is us.”
But not in Canada, eh? If only that were true. Clearly we are in a better position than our neighbours to the south, but that is no reason for complacency. Little problems quickly become big ones if they are not checked. On the health and safety front the damaging impact of disinformation is self-evident. Our much smaller quotient of vaccine resisters nevertheless prevents us from achieving the 80 to 90% level of fully vaccinated citizens needed to stem the pandemic tide. Meanwhile feed and seed stores are still getting misguided requests for invermectin. And a distressing number of individuals have chosen to lose their job rather than accept any form of the Covid vaccine.
The political damage caused by disinformation in Canada is less visible but more insidious. Over the past decade or so there have been a worrisome number of political issues that have been tainted by deliberate disinformation campaigns, and they did not emerge out of nothing. The groundwork was laid some time ago. Back in the 1990’s, for example, the Reform Party led by Preston Manning developed a surprisingly effective technique for criticizing many government policies – they simply labelled them “undemocratic.” All Canadians knew that this was a bad thing, but few knew whether the policies in question actually were undemocratic or not because they had such a slim grasp on the term “democratic” to begin with. Many assumed Manning knew what he was talking about because he was, after all, the leader of a major federal political party. (This would be the same Preston Manning who recently called for a “truce” between the vaccinated and unvaccinated,[i] a message that was widely derided and certainly called into question his judgement.)
A decade later, Manning’s former collaborator and then Conservative prime minister, Stephen Harper, likewise managed to convince a majority of Canadians that coalition governments were not only undemocratic but very nearly a coup d’etat. Ironically, as countless experts pointed out, it was Harper’s use of prorogation, to escape being defeated by the proposed coalition in parliament, that was undemocratic, a move they referred to as “a flagrant breach of parliamentary practice” and “an assault on democracy.”[ii] Canadians, however, either believed him or were unconcerned, and returned Harper to power in the next election with a majority.
Harper similarly attempted to tar many other government institutions with a partisan brush. His views were most clearly revealed during his 2008 election campaign reference to a supposed Liberal bias in the independent judiciary and the non-partisan public service. Indeed, the numerous attacks on the “activist” judiciary by several of Harper’s ministers during his time in office eventually culminated in the prime minister’s own unprecedented criticism of the Chief Justice.
In this context, casting aspersions could be seen as merely the first step towards the discrediting of the institutions of liberal democracy, one inevitably followed by deliberate deception. Fast forward to the federal elections of 2019 and 2021, when the Conservatives falsely accused the Trudeau Liberals of planning to legalize all drugs, prohibit all types of firearms and introduce a capital gains tax on the sale of primary residences.[iii] And what are we to make of the fact that the People’s Party of Canada, led by maverick former Conservative MP Maxime Bernier, actually tripled its share of the popular vote in 2021 from 2019 on the basis of an antivax, anti-immigrant platform promoting disinformation at every turn?
While this type of activity may possibly be viewed by disinterested observers as the inevitable parry and thrust of election campaigns, the same cannot be said of the Conservative opposition’s various attempts to mislead Canadians on the implications of government legislation. True, the role of the Official Opposition is to oppose, but on the basis of fact and policy differences, not disinformation. One of the most striking examples of the latter in the previous parliament was the decision by the Conservatives to suddenly oppose Bill C- 10, (legislation to modernize the communications regulatory regime), a measure they had essentially ignored for several months as it made its way through the system. But when it became clear to them that the general public could be persuaded that this act constituted a serious infringement on privacy and freedom of expression they proceeded to attack it with a vengeance. Warning falsely that Canadians’ Facebook postings about their dog could be monitored by the CRTC, the O’Toole Conservatives’ communications machine went into high gear. Judging by the successful fundraising campaign they built around this issue, many voters were convinced.
However this opportunistic behaviour pales in comparison with the Conservatives’ handling of the file concerning the dismissal of two Chinese scientists from the infectious disease laboratory in Winnipeg. Because opposition parties have the most members on parliamentary committees in a minority parliament they were able to pursue what they perceived to be an important issue very aggressively. Well and good. But they did not stop there. Knowing that there were numerous legitimate concerns about national security they nevertheless continued to press the government for complete and unredacted disclosure of all relevant documents to the members of the committee, none of whom had the required level of security clearance. When the government proposed an alternative – the very one created and used by Stephen Harper to handle the Afghan detainee issue for which his government was under fire at the time– it was the Conservatives who summarily dismissed that option as unacceptable. What was more, they continued to insist that the government was “hiding” something and should “come clean,” despite the government’s repeated statements that it could not comply with their request as presented because of these national security concerns. Aided and abetted by the other opposition parties, they then pursued the matter in parliament and ultimately left the Speaker with little choice but to declare the government to be in contempt of parliament.
Yet the Conservatives, who alone have led the charge on this issue once again in the new parliament, know full well that their position is not only unreasonable but deliberately misleading. There is no cover up here. As several former senior public servants have stressed, Canada’s position vis a vis its Five Eyes and NATO partners would be irreparably damaged if sensitive material were to be released as the Conservatives demand. The mandarins conclude “The government is accountable to our allies for enforcing standards and backing them up with laws restricting the disclosure of secrets. Our allies would simply not accept that the exigencies of a minority parliament would oblige the government to void established secrecy laws and agreements by turning over improperly vetted sensitive material to parliamentarians without security clearance.”[iv] In short, it is not the government that is being duplicitous but the Official Opposition.
While these examples may seem to be minor offences in contrast with the chaotic situation in the United States and some other liberal democracies in Europe, they are important indicators of the state of Canadian democracy. As a British parliamentary committee concluded after studying coalition governments in several Commonwealth countries, the attempted 2008 Canadian example was unhelpful not only because it failed, but also because of why it failed, namely because of Stephen Harper’s successful efforts to discredit the entire concept of coalition government. “Canadians in general” they wrote, “displayed a shocking lack of understanding of their system of government.”[v]
Clearly, more needs to be done by the media and educators to ensure that Canadians are better informed. Voters must know how to separate fact from hyperpartisan propaganda and falsehoods if we are to avoid the potential pitfalls of the current age of disinformation.
[i] Preston Manning. “Despite our Differences on Covid, Let’s Call a Christmas Truce”. Letter to the Editor. Globe and Mail. December 23, 2021.
[ii] For more detail see N. Wiseman. “The Use, Misuse and Abuse of Prorogation.” Hill Times, Jan 3, 2010.
[iv] Kergin, Fyffe and Mitchell. “Canada Will be Weakened if it Loosens Rules Around Releasing Intelligence.” Globe and Mail. Dec. 31, 2021.
[v] United Kingdom. House of Commons Committee on Political and Constitutional Reform. Report. Vol.2 January 28, 2011.


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John the Fearless
In stock (1 available)
John the Fearless (French: Jean sans Peur ; Dutch: Jan zonder Vrees; 28 May 1371 – 10 September 1419) was Duke of Burgundy (the second of the Valois dynasty) as John I from 1404 until his death. A scion of the royal house of France, he played an important role in French affairs during the early 15th century, in particular the struggles to rule the country for the mentally ill King Charles VI (his first cousin) and the Hundred Years’ War with England. His rash, unscrupulous, and violent political dealings contributed to the eruption of the Armagnac–Burgundian Civil War in France, and culminated in his assassination in 1419.
The involvement of Charles, the heir to the French throne, in his assassination, prompted John’s son and successor Philip to seek an alliance with the English, thereby bringing the Hundred Years’ War to its final phase.

domain: library


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In a recent publication in the Journal of Post-Acute and Long-Term Care Medicine, there was a discussion regarding finding the right balance on opening visitation in nursing homes and distinguishing between family caregivers and social visitors. The information is interesting and summarized below for your reading pleasure. The link for the complete article is also included if you would like to review the information in its entirety.
Family Caregivers Versus General Visitors
- Must differentiate between “family caregivers*” and “general visitors”. Residents substitute decision makers and their families should have the authority and autonomy to determine who is essential to support them in their care.
- Although socialization is certainly important, family caregivers* as partners in care should be prioritized to support resident health and well-being.
- Family caregivers also help ensure that all residents receive culturally safe and appropriate care, especially for LGTBTQ2S and indigenous residents and/or those with language barriers.
- Although family caregivers are used frequently, it is important to recognize that approximately 15% of all caregivers are not related to their care recipients including some who may be privately hired.
- The importance of identifying family caregivers* is that they are not accessing the nursing home primarily for social reasons but rather to provide services and care such as assistance with feeding, medical decision-making and management of responsive behaviors among residents living with dementia.
- Substitute decision-makers should make this determination for incapable residents.
- Initially each resident should be supported in allowing the reintroduction of at least 2 family caregivers and these individuals should receive a caregiver identification card or badge.
*Family caregivers are those individuals who assume essential caregiving responsibilities for a spouse, family member or friend who needs help because of limitations in their physical, mental or cognitive functioning, and are essential to meeting the needs of residents especially in the face of chronic staffing shortages.
Restricted Access – Balance the Risks
- Restricted access to visiting must balance the risks of COVID-19 infection with the risks of social isolation to resident health, well-being and quality of life.
- Strict, blanket “no visitor” policies were enacted early on during the pandemic.
- It is essential that we focus on the considerable detrimental effects of the ongoing lockdown of nursing homes and restricted access to family caregivers and general visitors.
- Many residents have experienced severe and potentially irreversible functional and cognitive declines, deteriorations in physical and mental health, severe loneliness and social isolation, worsening of responsive behaviors and increased use of psychotropic medications and physical restraints.
- Many residents have died alone without family present to support end-of-life needs.
- Theses negative outcomes have raised concerns that the risks associated with ongoing blanket visitor restrictions outweigh the benefits associated with preventing COVID-19 outbreaks in nursing homes.
- These restrictions may also be violating the autonomy of residents and their right to make informed and risk-based decisions which prioritize their access to visitors over the risks of them contracting COVID-19.
- There is now a much better understanding of public health guidance and recommendations including universal masking as well as increased access to testing for the general public which will further reduce the risk of COVID-19 being introduced into nursing homes.
- As partners in care, most family caregivers may already be trained and experienced in infection control and PPE procedures because other infectious outbreaks are not uncommon in nursing homes.
Equity over Equality
- Visitor policies must prioritize equity over equality, recognizing that a “one size fits all” approach is neither optimal nor practical.
- Equality would mean giving all nursing home residents the same access to visitors.
- Equity means giving nursing home residents the right amount of access they need to maintain their health and well-being.
- Visitor policies should not prioritize the convenience of the nursing homes over the best interest of their residents in receiving the care and support of family caregivers and visitors.
- Nursing homes must reserve the right to create and implement visitor screening protocols consistent with local public health guidance and procedures for visits that maintain the safety and well-being of all residents and staff.
- Blanket implementation of policies should be avoided and instead, policies uniquely supporting family caregivers and general visitors should be both flexible and compassionate, recognizing that some of the new conditions and procedures surrounding visiting may not work for all residents, family caregivers and visitors.
- Provide flexibility around the timing of visits, the location of visits, the length or frequency of visits, absolute restrictions on physical contact, etc.
- Family caregivers and general visitors must e able to receive the necessary PPE to facilitate these visits from the facility.
- It is important that ample PPE supplies are available as a lack of supply could restrict access to visitors and negatively impact resident quality of life.
4. Transparent, Accessible, Evidence-Based Communication and Direction
- Governments, public health authorities and nursing homes must provide regular, transparent, accessible and evidence-based communication and direction about visitor policies and access.
- Many nursing home residents and their families and friends have grown increasingly frustrated about a lack of transparency and regular communication regarding the development and implementation of visitor policies and restrictions.
- It is important that we be transparent about who is responsible for decision-making, which evidence and metrics are being used to develop and monitor responses to visitor policies and what are the timelines and outcomes for progression and regression of phased responses.
- If visitor restrictions are required, they should be implemented in a transparent manner with the same open and clear communication provided to residents as well as their family caregivers and family members.
5. Data Related to Re-Opening Nursing Homes
- Collect and report data on COVID-19 cases as it relates to reopening in collaboration with local health authorities and public health units.
- It is true that it is less difficult to impose restrictions than it is to remove them.
- Public Health and governmental authorities should be actively working to use modeling and evidence to remove visitor restrictions as quickly as possible as regional community prevalence declines.
- The Resident Assessment-Minimum Data Set 3.0 is completed quarterly and with change in condition. This information can assist in assessing the impact of both restricted visitor access and the reintegration of visitors on resident health and well-being.
6. Feedback and a Process for Rapid Appeals
- There appear to be marked inconsistencies in how regional visitor policies are being interpreted and implemented.
- Residents, family caregivers and visitors in all jurisdictions need access to a feedback and appeals process.
- Recognizing that ombudsmen and existing nursing home complaint and support lines do not function as arbitrators in these situations, homes should create a mediating appeals mechanism consisting of nursing home staff and members of existing resident and family councils to assist in resolving disagreements around visitor policies and the designation of family caregivers.
Remember, at the end of the day it is what you do that makes you special. Thank you for the continued care of your residents, families, and staff, stay well, stay safe, and stay tuned!


The recent spate of DDoS attacks on US banks and the comments by ENISA’s Security expert and chairman of the Security Group ISACA John Warren about the lack of preparedness of EU banks is also borne out by a survey carried out earlier this year by DDoS experts Corero. The survey (conducted amongst IT Directors of 200 US organisations and 100 UK organisations) showed that 33% of organisations in the financial sector had no technology in place to protect them against DDoS attacks. It also revealed that US financial organisations were more concerned than their British counterparts about the threat posed by DDoS attacks: 68% of US respondents were concerned about the threat of DDoS attacks compared to just 28% of UK respondents. This could be explained by the fact that more US companies had experienced one or more DDoS attacks in the last 12 months (36%) against 24% of UK companies.
Interestingly, though the recent attacks reportedly on US Bank, PNC, Well Fargo, Bank of America and Chase Bank are believed to be instigated by Muslim extremist group Izz ad-Din al-Qassam cyber fighters, none of the US companies had claimed to have experienced a DDoS attack motivated by political aims. The main reason cited for prior attacks was businesses seeking to gain a competitive advantage over competitors. 33% of UK banks had however experienced attacks motivated by political reasons.
Paul Lawrence, VP International Operations for DDoS mitigation experts Corero, comments, “In our experience financial organisations are slightly ahead of other businesses in the appreciation of the threats that DDoS attacks represent to their business, however many are lulled into a false sense of security by thinking that traditional means of defence like firewalls will combat the threat. Unfortunately it’s often only when they’re the victim of attacks like those that have hit US banks that they realise that firewalls are unable to cope with such large volumetric attacks. Their organisation may also be experiencing other more subtle Application Layer DDoS attacks that go completely unnoticed as they appear to be legitimate traffic but which can also negatively impact their business without them even realising it.”


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I have used other services in the past but very pleased I switched. I loved being able to pay with my visa and my order was waiting for me when I checked in.
Garden Grocer was great - had an awesome selection, and the delivery fee was well worth the convenience of arriving and having our fridge already stocked! I would definitely use them again when we were on vacation
Great service when staying at a Disney resort. Easy to use site. Great service.

domain: travel


text: I’ve always loved to read, but also loved to collect, store, stack and deposit books on every available shelf, table and unoccupied seat in my home. Earlier in my life I was most interested in crime and thrillers, but as time has done its thing I’ve become more drawn to non-fiction and in particular to books which explain the natural world and our relationship with it, quite often through the biographies of extraordinary people. Most of my working life has been dedicated to creating live events and in particular curating programmes of (I hope!) fun and informative content. I’m currently Festival Director for the London Mountain Film Festival where I am privileged to be involved with London’s thriving adventure and outdoor communities and with documentary filmmakers on every continent.

domain: entertainment


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Dir: Eric Steel. UK-US. 2013. 80mins
An elegant and fascinating delight, Kiss The Water is made with insight, intelligence and a painterly delight in perhaps one of the most unusual of documentary subjects – the lyrical story a rare and enigmatic Scottish woman who became a legend in the world of making flies for salmon fishing.
It also acts as a brilliant advertisement for the beauties of Scotland and features some astonishingly painted animation by filmmaker Em Cooper.
Directed with simplicity and charm by Eric Steel (whose last film was the rather different The Bridge, about suicides at San Francisco’s Golden Gate Bridge), the film dwells on the strange charm of fly fishing and the unusual habits of salmon while charting the life story of a an equally beguiling woman who taught herself the art of fly-tying and would go on to make flies for royalty.
Following a world premiere at the Tribeca Film Festival, the film screened at its spiritual home, the Edinburgh International Film Festival, but should also be a shoe-in at other film festivals. It also acts as a brilliant advertisement for the beauties of Scotland and features some astonishingly painted animation by filmmaker Em Cooper.
The core of the film is the story of Scottish Highlander Megan Boyd, always an outsider – androgynous to look at and always wore a tie – who taught herself fly-tying from a book. Living in a remote house with no electricity she was an enigmatic figure and would come to be the favourite fly-tier for Prince Charles (or Charlie as she always called him) who would occasionally visit her at her remote house.
There is no actual footage of Megan until the film’s final moments, instead Steel cross-cuts between footage of her now ramshackle house; interviews with those who knew her or worked with her, or simply talk about salmon fishing; atmospheric footage of Scotland at its most beautiful and Em Cooper’s stunning animation.
Production Companies: Easy There Tiger, Slate Films
Contact: Easy There Tiger, www.easytigerproductions.com
Producers: Eric Steel, Kate Swan
Executive producer: Andrea Calderwood
Cinematography: Ole Bratt Birkeland
Editor: Sabine Krayenbuhl
Animation director: Em Cooper
Music: Paul Cantelon
Music: Paul Cantelon


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Seed Bead Bracelets
Handmade Victorian Butterfly Peyote Bracelet Cuff
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domain: design


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John Bell Scholarship
Interested in a career as a performer and attend school in a regional area? Audition for the John Bell Scholarship.
A life-changing opportunity for budding performers, three students will spend one incredible week training with Bell Shakespeare at our HQ in Sydney.
Winners will undertake acting masterclasses with Bell Shakespeare artists, observe rehearsals, receive specialist training, see live theatre, and more. They will also have the opportunity to perform their winning monologue for Founding Artistic Director John Bell, Artistic Director Peter Evans, and Bell Shakespeare artists, receiving feedback and mentoring.
All auditioning students will undertake a 15-minute, one-on-one Workshop Audition where they will work directly with a Bell Shakespeare artist.
Auditions for our 2025 Scholarships will open from Term 2, 2024. Schools and organisations that will be attending a Regional Workshop as part of our 2024 A Midsummer Night's Dream national tour, will be available to organise an in-person audition prior to Term 2. Contact email@example.com for more information.
Who is eligible?
Applicants must be 16 years of age or older by 31 December 2024 and be enrolled in a regional high school full-time in 2024.
What is the selection process?
Auditions take the form of a 15-minute Workshop Audition with a Bell Shakespeare artist where students perform a prepared monologue from the 2024 monologue list, receiving feedback and direction from a professional Bell Shakespeare artist. Up to three students will be selected for the scholarship from across Australia.
John Bell Scholarship auditions take place in person and via Zoom. To download and prepare a monologue, please refer to the 2024 monologue list.
Students from culturally and linguistically diverse backgrounds are strongly encouraged to apply.
How do I apply?
- Register for your Workshop Audition by completing the online registration form. Note: You will not be eligible for the scholarship if we do not receive this form. We will let you know if we can audition you in person, and the available dates. If we are not able to audition you in person, we will arrange a live audition via Zoom.
- Select your audition piece from our 2024 monologue list. There’s a mix of characters from Shakespeare’s plays, from tragedy to comedy. Take your pick and rehearse your chosen character in your own unique way.
- Prepare for your Workshop Audition using our Tips For Auditionees.
It was an amazing experience and it honestly has opened up so much more opportunity for me in the future.

domain: artistic


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the dumbest thing is when parents say “this isnt how i raised you” like ?????? yes it really is you literally raised me and here i am
my anaconda don’t want none unless you got a hotdog, some tater tots. Oh, and, also, a slice of pepperoni pizza, and, also a basket of jalapeno poppers, and some chicken nuggets, a ketchup boat, three potato pancakes, a creamsicle, two quesadillas, a bread loaf, side of ranch, some pixie sticks, taco salad, an order of ribs, aaaand a diet coke- no. Strawberry shake. No! Diet Coke. NO! Both HUN!
do you ever remember how tall luke is and you feel smalla then a bug


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The tension increases when you find yourself in a virtual world. You go through the room at least a couple of times, searching for information and you are pondering whether there's an escape plan. It is a part of the plot in the latest online type of escape room games.
Escape games are merely an introduction to the emerging time of arcade games in which players are able to experience an immersive virtual world, where they'll be able to grasp an understanding of the excitement that is associated with the environment in which the game is played. If you want to take the best experience of the escape room game online visit tryreason.com/moonshot/.
The Escape games online are the most popular kind of arcade game for free that is available on the Internet. Online arcade sites offer these games in an increasing variety of styles. They are created in the glimmer phase and make use of controls, which typically incorporate the bolt that enters your console as well as a proper movement of the mouse in order to identify things.
In the normal plot, the player begins in a restricted space. The surroundings will contain a variety of objects, including hidden keys and locked access points. The goal that the player must answer is to look through the area for information that can trigger the escape from your current control.
However, the majority of clues are concealed and are secured with a baffling player must unravel prior to tackling the answer. As you progress and go closer to the most frightening escape room online, you'll find an array of similar games featuring a broad selection of realistic detail topics, subject matter, and difficulty levels.


THANK YOU! I was waiting for someone to take the bait. Let’s dive in and look at the actual report. NYT does a BRILLIANT rhetorical flourish in that revisionist report. You’ll notice that they are looking at lethal attacks. It turns out that far more Muslims are arrested and convicted before the attack is able to be launched. Another detail you seemed to have missed is that I mentioned proportionality — Muslims account for less than 1 percent of the population and yet are responsible for a much greater percentage of terror-related offenses.
Below I provide the chart from the actual report — God forbid NYT be intellectually honest about things.
It’s also important to note that most Muslims are white. Arabs are white according to the census too. Muslims aren’t a race.
Here’s how the NYT decided to take the numbers and boil it down — they decided arrests and plots don’t matter. Only deaths. Because I guess preventing crime isn’t a big deal?


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Day 4 of 30 Days of Adventure
Today, let's shine the light of curious attention and creative action amidst fears of the unknown.
Curiosity and creativity are inherent states of being.
As unique extensions of the loving creative energy that interweaves all things, we are imbued with the same loving will to explore and create. Observing with curiosity and engaging with creativity is a primary path to self-awareness. Everything we need to know and manifest can be found through a practice of curious observation and creative action. It's the natural process we follow as we're born into this human body.
With curious attention and creative intention, we are more empowered to make inspiring course-corrections along our adventure. So today, let's tap into our curious creative power to inform the next best steps on our adventure!
I objectively observe my thoughts, feelings, and beliefs.
I accept the wholeness of my experience.
I respond to all that arises with loving-kindness.
I play with the unlimited potential of my creative essence.
I trust intuitive insights to guide my next best step.
The tools for our curious discovery are limitless.
Listening, observation, imagination, playfulness, questioning, experimentation, courage … these are states of being that can inform our curiosity and inspire creative action. With perspective, all states of being can be seen as tools to create more freedom, joy, growth … or whatever it is we value most. Through our thoughts, feelings, and perceptions, every moment holds the opportunity to understand ourselves better and further create the life of our dreams.
Let's create a vision board for our adventure, with curious observation.
A vision board is a safe place to begin feeling into the unknown of our adventure. From the safety of our canvas (or journal), we can continue to notice what about this adventure excites us or makes us scared and make any adjustments that facilitate our personal growth and clarify our adventurous vision.
- Using the page we started yesterday, we should already have our:
- adventurous vision statement on the top of the page
- fear(s) that create resistance in the middle of the page.
- supportive affirmations surrounding our fear(s).
- Now, let's continue to ease these fears by adding layers to this adventure vision board with doodles, colors, imagery, magazine cutouts, food smears, or whatever materials that are on hand that bring your vision to life!
- If further fears arise, feel into them by allowing them space on the page. Notice how by simply acknowledging fear with loving awareness, it immediately begins to loosen its grip.
- In time, cover the written fears with more creative layers so that you end up with a supportive adventurous vision board!
- Play, create, and observe!
What came through for you on your vision board?
Whether it's a simple ensō circle around your vision statement or layers of mod podged cutouts, we'd love to see your adventurous vision board in the community comments!


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China’s PBoC announces standards to be followed by blockchain, Fintech groups
On the heels of Xi Jinping’s historical blockchain announcement, China recently announced the establishment of a national standards committee for blockchain technology to boost high-tech innovation. Keeping up with the principle of standardization, the Deputy Governor of the People’s Bank of China revealed the 17 categories of financial technologies to follow standards that have been systematized to guide the application of new technologies.
The Deputy Governor, Yifei Fan, while speaking at a meeting of the National Technical Committee, said that the bank aims to improve the regulation of new technologies across the financial industry, a report claimed. One of the mentioned categories was blockchain, alongside artificial intelligence and cloud computing, with regulations under the new standards now being sought.
According to a report, Fan added,
“The financial industry either lacks the standards or needs to update the existing standards. The current regulations for financial services are not clear and strong enough to guide high-quality developments in the industry.”
China has confirmed 65 national financial standards and 252 financial industry standards, which have been strongly supported for the healthy development of the financial industry. Additionally, the official body has launched 20 group standards, including Internet financial information disclosure standards.
The present announcement follows the two other industry standards formulated by the government. These standards were for registering new blockchain projects and also for 11 Fintech product categories in digital payments. The report concluded by stating,
“Fan Yifei emphasized that it is necessary to speed up the internationalization of financial standards, actively carry out financial standardization research, and strive to cultivate a new era of financial standardization talents, and promote financial standards to play a fundamental and strategic role in the modernization of financial governance systems and governance capabilities.”

domain: finance


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U.S. Marine Corps photo by Lance Cpl. M. C. Nerl/Released 100420-M-0000L-002.jpg
Apr 20, 2010
MARINE CORPS AIR GROUND COMBAT CENTER TWENTYNINE PALMS, Calif. - Instructors at the Combat Center's newest range teach Marines such skills as detecting hidden improvised explosive devices, like the wired up mortar round shown here. The new range is Combat Center Range 800, made for tenant units preparing for deployments to Afghanistan.
No camera details available.
This photograph is considered public domain and has been cleared for release.
If you would like to republish please give the photographer appropriate credit.
Further, any commercial or non-commercial use of this photograph or any other
DoD image must be made in compliance with guidance found at
which pertains to intellectual property restrictions (e.g., copyright and
trademark, including the use of official emblems, insignia, names and slogans), warnings
regarding use of images of identifiable personnel, appearance of endorsement, and related matters.