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Call : - +91 9166497735
Email : - firstname.lastname@example.org
Discover the land of royals in our exclusively designed 8 nights 9 days Rajasthan tour package. This tour lets you experience the enriched beauty of Rajasthan as you discover the famous cities of the state. It includes a visit to Jaipur, Ajmer, Udaipur, Jodhpur, and Jaisalmer. In this holiday package, you will get to see the famous historic forts, royal palaces, ancient temples, artificial lakes, and many other tourist attractions of the cities. For customizing this tour, feel free to talk to our travel experts on call will help you to plan a journey according to your interest.
Tour Duration: 8 Nights 9 Days
Destinations Covered: Jaipur – Ajmer – Udaipur – Jodhpur – Jaisalmer
Day 1: Jaipur Arrival
Your arrival in Jaipur will be greeted by our escorting tour manager who will assist you reach the hotel for checking in and freshen up. Take rest for a while and then leave for exploring the city. This will include a visit to Birla Temple, Albert Hall Museum, and colorful Jaipur Bazaars to go shopping spree. Afterward, you will be taken to the hotel for a night's stay.
Day 2: Jaipur sightseeing
Wake up fresh in the morning and get ready to explore the famous heritage city of India – Jaipur. After breakfast, meet our representative outside the hotel who will accompany you to explore the famous tourist places in Jaipur's full-day sightseeing tour. This covers a visit to Amber Fort & Palace, Jal Mahal, Hawa Mahal, City Palace, and Jantar Mantar. Afterward, return to the hotel for an overnight stay.
Day 3: Ajmer Transfer & sightseeing
On the 3rd day of the tour, get ready to explore the famous holy city of Rajasthan, Ajmer. As you arrive there, complete the check-in process and leave for a visit to Dargah Sharif of Khwaja Moinuddin Chishti, Ana Sagar Lake, and Akbar Palace and Museum. Later, return to the hotel for an overnight stay.
Day 4: Udaipur transfer via Pushkar
In the morning, wake up early to get ready and leave for a drive to Udaipur. On the way to Udaipur, mark a pitstop at Pushkar. The famous holy city of Rajasthan, Pushkar, is widely known for its prominent Brahma Temple and Pushkar Lake. Visit these spiritual places and then resume a drive to Udaipur. After reaching there, check in to the hotel and freshen up. Later, get ready to enjoy a relaxing time while boating at Lake Pichola, where you will see the breathtaking views of the sunset over the lake. Afterward, return to the hotel for a night's stay.
Day 5: Udaipur sightseeing
Post breakfast, get ready to enjoy a fun-filled day in Udaipur, where you will be exploring the famous tourist places of the city. This includes a visit to City Palace, Jag Mandir, Jagdish Temple, Saheliyon ki Bari, Monsoon Palace, and Bagore ki Haveli.
Once you are done exploring these architectural wonders of the city, get a transfer back to the hotel for a comfortable night's stay.
Day 6: Jodhpur transfer & sightseeing
Today, get ready after breakfast and check out to leave for a drive to Jodhpur. Famously known as the Blue City or the Sun City of Rajasthan, Jodhpur draws tourists from across the country to explore the historic architectural jewels. Arrive and complete the check-in process of the hotel where you will drop your luggage and then leave for an exploration of Jodhpur. Embark on a visit to Mehrangarh Fort, Jaswant Thada, and Umaid Bhawan Palace. After a sightseeing tour of the city, you will be dropped to the hotel for an overnight stay in Jodhpur.
Day 7: Jaisalmer Transfer & sightseeing
On the third day of this tour, you will be transferred to Jaisalmer city. Post breakfast, complete all the check-out formalities from the hotel, and start the day with a visit to Toorji ka Jhalra, and from there proceed to Jaisalmer city.
On the way to Jaisalmer, you will take a halt at Jaisalmer War Museum. Then resume a drive to Jaisalmer and check in to a hotel for a relaxing stay. Then you can enjoy your free time with your family members at Gadisar Lake where you can enjoy boating and capture stunning sunset views. After that in the evening, you can go for a walk and visit nearby shops to get some traditional souvenirs. Then get back to the hotel and stay there overnight.
Day 8: Jaisalmer sightseeing
After a hearty meal in the morning, get ready to explore prominent landmarks of the golden city. This covers a visit to Jaisalmer Fort, Patwon ki Haveli, Salim Singh ki Haveli, Nathmalji ki Haveli, and Bada Bagh.
After a sightseeing tour of Jaisalmer city, visit the golden sand dunes to enjoy Camel Safari, Jeep Safari, Dune Bashing, Cultural Evening, and night camping. The night stay can either be at the camp or hotel in Jaisalmer
Day 9: Departure
The last day of this tour will conclude on a memorable note. Before final drop at the railway station in Jaisalmer or airport in Jodhpur (according to your preference), we shall visit Tanot Mata Temple and Longewala War Memorial. Later, you will be escorted to board a flight or train for your hometown. The tour ends here.


Red Bull Cliff Diving World Series
Possum Lake, Fort Worth, United States
27 June 2020Cancelled
This event has been cancelled
Expect red-hot weather and a boisterous atmosphere when the cliff diving elite return to Texas this summer to touch down in the placid waters surrounding Hell’s Gate at Possum Kingdom Lake.


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In recent years, the tiny house movement has gained significant traction, offering a minimalist and sustainable lifestyle to those seeking a break from the conventional. Renting a tiny house can be an excellent way to dip your toes into this unique living experience, whether it’s for a weekend getaway or a longer-term adventure. If you’re new to the idea of tiny house living, fear not! This comprehensive guide will walk you through everything you need to know about renting a tiny house for the first time.
What is a Tiny House?
Before we delve into the nitty-gritty of renting, let’s start with the basics. A tiny house is typically a compact dwelling, often ranging from 100 to 400 square feet in size. These homes are ingeniously designed to maximize space efficiency without sacrificing comfort. They come in various styles, from sleek modern designs to charming rustic cabins, catering to diverse tastes and preferences.
Why Rent a Tiny House?
Renting a tiny house offers a myriad of benefits for adventurers and minimalists alike. Here are a few reasons why it might be the perfect choice for your next getaway:
- Affordability: Tiny house rentals are often more budget-friendly than traditional vacation accommodations, allowing you to experience a unique stay without breaking the bank.
- Sustainability: Many tiny houses are built using eco-friendly materials and incorporate energy-efficient features, making them a greener choice for conscientious travelers.
- Coziness: Despite their small size, tiny houses are designed to be cozy and inviting, providing a snug retreat from the hustle and bustle of everyday life.
- Minimalism: Embracing a minimalist lifestyle can be liberating, and renting a tiny house allows you to experience the joys of living with less clutter and excess.
Finding the Perfect Rental
Now that you’re sold on the idea of renting a tiny house, it’s time to find the perfect rental for your needs. Here’s how to get started:
- Online Platforms: Utilize online platforms dedicated to tiny house rentals, such as TinyHouseVillage.de. These websites offer a wide selection of properties in various locations, allowing you to browse and book your ideal getaway with ease.
- Read Reviews: Before committing to a rental, take the time to read reviews from previous guests. Their experiences can provide valuable insights into the quality of the accommodation and the host’s hospitality.
- Check Amenities: Consider your must-have amenities, whether it’s a fully equipped kitchen, a hot tub, or Wi-Fi access. Make sure the rental you choose meets your requirements for a comfortable stay.
- Location, Location, Location: Think about the location of the tiny house and what you hope to get out of your stay. Whether you crave seclusion in nature or prefer to be close to urban attractions, choose a location that aligns with your preferences.
Preparing for Your Stay
With your rental booked, it’s time to prepare for your tiny house adventure. Here are a few tips to ensure a smooth and enjoyable experience:
- Pack Light: Space is limited in a tiny house, so pack only the essentials. Opt for multipurpose items and clothing that can be easily layered for versatility.
- Mindful Consumption: Embrace the ethos of sustainable living by being mindful of your consumption during your stay. Conserve water and energy wherever possible and dispose of waste responsibly.
- Respect the Space: Treat your tiny house rental with care and respect, just as you would your own home. Follow any house rules provided by the host and leave the space clean and tidy upon departure.
- Embrace the Experience: Above all, embrace the experience of tiny house living with an open mind and adventurous spirit. Whether it’s stargazing from your loft bed or enjoying a morning coffee on your private deck, savor every moment of your stay.
Renting a tiny house offers a unique opportunity to simplify your life, connect with nature, and experience the joys of minimalist living. By following this ultimate guide, you’ll be well-equipped to embark on your first tiny house adventure with confidence and excitement. So go ahead, book that rental, and get ready for a memorable getaway unlike any other!

domain: travel


PEOPLE may be requesting testing for coronavirus in the region's hospitals, but there have been no confirmed cases of the virus in the Western NSW Local Health District.
The second Australian death from coronavirus (COVID-19) has occurred overnight when a 95-year-old nursing home resident in Sydney died.
This comes after a 78-year-old man in Perth who died from the infection.
Some 10,000 people have been tested for COVID-19 across the country with more than 40 confirmed cases, of whom 21 have now been cleared, Australian Associated Press reports.
A Western NSW Local Health District spokeswoman confirmed on Thursday morning that people have been entering hospitals across the region fearing they have contracted coronavirus.
READ MORE: The latest on coronavirus across Australia
"We have conducted tests because people are asking to be tested," she said.
"We have had no confirmed cases."
A Central West GP says there are certain age groups more at risk of coronavirus, with some pre-existing conditions leaving people more susceptible.
Cover coughs and sneezes
You should cover your mouth and nose with a tissue when you cough or sneeze, or cough or sneeze into your sleeve/elbow.
Used tissues should be placed in a bin, and hands immediately washed with soap and water for at least 20 seconds.
Wash your hands
You should wash your hands often and thoroughly with soap and water for at least 20 seconds. You can use an alcohol-based hand sanitiser if your hands are not visibly dirty.
Ensure you wash your hands or use a hand sanitiser:
- before entering an area where there are other people
- before touching things used by other people
- after using the bathroom
- after coughing or sneezing
- before putting on, and after removing, gloves and masks


A DEVELOPER wanting to build homes on a site in Caversham has listened to angry neighbours who opposed its plans.
Bewley Homes had planned to put up three buildings with between 91 and 109 flats on the site of the former White Knight Laundry in George Street.
The blocks would have varied in height from three to five storeys.
But the developer withdrew the application at a Reading Borough Council planning meeting in August in the light of strong opposition from neighbours.
People living in Queen's Road were especially worried that the imposing development would invade their privacy.
Now, after hooking up with residents' associations and Councillor Andrew Cumpsty, the company has decided to work on another design.
Andrew Brooks, a director at Bewley Homes, said yesterday the number of dwellings would now be reduced to 76.
He added that houses would be built on the part of the site opposite Queen's Road rather than a tall block of flats.
Cllr Cumpsty said: "I had spoken out against the original development saying it would look like a tanker heading down towards the Thames.
"I got a call from one of the directors saying the proposals were going nowhere and could we arrange to meet.
"Bewley Homes wanted to hear what residents had to say about it and it is now saying it will go away and refine the plans further and submit new ones.
"I am very pleased Bewley Homes is taking this positive approach. It's very encouraging."
Reading Borough Council had already rejected two previous applications before the company withdrew the latest scheme.
Caversham Globe, Caversham and District Association (CADRA) and the Lower Caversham Residents' Association attended the meeting.
Caversham Globe's Isobel Ballsdon said: "I think it was a very positive move by the developers to take up Cllr Cumpsty's suggestion of meeting local groups."
Helen Lambert, who chairs CADRA, added: "It was a successful meeting and the new proposition is certainly an improvement."
However, both organisations still have concerns over the impact the flats and houses will have on traffic.
Mr Brooks said the company hoped to have a new application in before the end of the year.
He said: "We thought we might be able to move this scheme forward in a way that might be looked at better by the people of Caversham.
"We have now developed a new design for a new scheme with these views in mind."


Celebrates new album “Things That Can’t Be Undone”
recorded with 2016 Grammy nominee Producer Dave Cobb“The pairing of Lund and Cobb on Things That Can’t Be Undone is a feather in both their caps; as an album, it forges a new path in country music, yet remains exceptionally close to the tradition’s heart.” – AllMusic.com
TORONTO – After lauching his new record Things That Can’t Be Undone worldwide on US label New West Records this fall, Juno award-winning artist and heartthrob cowboy Corb Lund begins the new year taking Alberta culture on the road. Corb and his longtime band The Hurtin’ Albertans tour the Netherlands, Germany and England before returning to Canada at the end of January for his first two month tour of his home and native land since recording the album in Nashville with 2016 Grammy Award nominee producer Dave Cobb.
The record has received rave reviews in the US, Canada and UK. The album remains in the top ten of Americana charts since its release in North America. MOJO writes,“It’s great credit to both Lund and his versatile backing band, The Hurtin’ Albertans, that such see-sawing through genres can sound so much like a singular piece of work.” NPR hailed it as “the high mark of a long career” in their “Songs We Love” premiere of the powerful “Sadr City,” a tragic tale about the Siege of Sadr City, the first big flare-up of sectarian violence in Iraq after Mission Accomplished. Rolling Stone Country, who also premiered the Stax Records-steeped album opener “Weight Of The Gun” recently singled out Lund for their “10 New Country Artists You Need To Know.” In Popmatters’ 8/10 review they said,“Melodically engaging and narratively compelling, Things That Can’t Be Undone furthers the case for Corb Lund as one of the best contemporary country songwriters.”
Corb Lund’s Things that Can’t Be Undone was named one of CBC’s Best Canadian Albums of 2015 and topped several year-end lists including The Boot, Boston Globe and Americana Music Show. The song “S Lazy H” brings back heart-wrenching classic storytelling and was included in American Songwriter’s Top 50 Songs of the Year and NPR Music’s Favorite Songs Of 2015
Juno award-winner Corb Lund is supporting his latest New West Records release “Things That Can’t Be Undone” recorded with (current) Grammy nominee for Producer of the Year, Dave Cobb, in Nashville, Tenessee. The tour began in Victoria, BC, this January. He’s touring with his longtime band The Hurtin’ Albertans.
Feb 12 – ELLIOTT LAKE, ON – Lester B Pearson Civic Centre
Feb 15 – LONDON, ON – London Music Hall
Feb 16 – PETERBOROUGH, ON – The Venue Peterborough
Feb 17 – MONTREAL, ON – Theatre Fairmount
Feb 18 – KINGSTON, ON – Grand Theatre
Feb 19 – OTTAWA, ON – National Arts Centre
Feb 20 – TORONTO, ON – Winter Garden Theatre


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A low potassium diet is described as one in which the daily potassium consumption is between 2000 and 3000 mg.
What can you eat to lower your potassium level?
- Weight loss with dietary modifications
Can I eat eggs on a low potassium diet?
Potassium content of a big egg is around 63 mg. 1 Eggs are considered a low-potassium food; nonetheless, you should consult with your doctor or nutritionist to determine how frequently you should consume them.
What meat is low in potassium?
Clams, oysters, and tuna are among the meats with the lowest potassium content. Despite the fact that chicken and turkey are not considered low-potassium meats, their potassium content is lower than that of other varieties of meat. The potassium content in deli meats is not just high, but it may also be high in sodium, and it may have phosphorus additions as well.
How do you flush excess potassium?
Oysters, clams, and tuna are some of the meats that have the least potassium. Despite the fact that chicken and turkey are not considered low-potassium meats, they do contain less potassium than other types of meats. The potassium content in deli meats can be high, but it can also be high in salt, and it may have phosphorus additions as well.
- Water tablets (diuretics) are used to flush out excess potassium from the body. They function by increasing the amount of urine produced by your kidneys. Potassium is generally excreted in the urine stream. Potassium binders are frequently available in the form of a powder. They are eaten with food after being combined with a tiny amount of water.
Can drinking a lot of water lower potassium?
The use of excessive amounts of water can result in a variety of negative effects ranging from moderately irritating to life-threatening — and overhydration can result in an imbalance of electrolytes in the body. Electrolytes such as potassium, sodium, and magnesium assist control everything from the function of your kidneys to the operation of your heart.
Which milk is lowest in potassium?
Choose soy, almond, cashew, or rice milk instead of cow’s milk if you want fewer phosphorus and potassium in your diet. Make sure to steer clear of any cow’s milk replacements that are “enriched” or that have the words phosphorous or “phos” in the ingredient list.
Can you eat oatmeal on a low potassium diet?
If your doctor has prescribed a low-potassium diet, you should be able to eat oatmeal a few times each week if you follow the guidelines. If, on the other hand, you must restrict phosphorus intake owing to renal problems, you may need to limit or eliminate oatmeal altogether, substituting cream of wheat or grits instead when you have a need for hot cereal.
Does cheese have a lot of potassium?
Potassium content of cheeses with big serving sizes is often higher than that of smaller serving sizes. 1 cup of low-fat cottage cheese, for example, has 217 mg of potassium and is therefore considered a potassium-dense meal. 2/3 of a cup of ricotta cheese is also classified as high-potassium food due to the fact that it contains 205 mg of potassium per serving.
What vegetables have no potassium?
Among the low potassium veggies are cilantro, alfalfa sprouts, lettuce, kale, Napa cabbage, leeks, spaghetti squash, sweet onions, eggplant, and other vegetables with a bitter taste.
Does chicken have a lot of potassium?
Coriander, alfalfa sprouts, lettuce, arugula, kale, Napa cabbage, leeks, spaghetti squash, sweet onions, eggplant, and other low-potassium veggies are available.
Is rotisserie chicken high in potassium?
Cilantro, alfalfa sprouts, lettuce, arugula, kale, Napa cabbage, leeks, spaghetti squash, sweet onions, eggplant, and other low potassium veggies are available.
What are signs that your potassium is high?
What are the signs and symptoms of hyperkalemia (abnormally high potassium levels)?
- Chest discomfort.
- Heart palpitations or arrhythmia (an irregular, rapid, or fluttering heartbeat).
- Abdominal (belly) pain with diarrhea. A feeling of muscle weakness or numbness in the limbs. Nausea and vomiting are common.
What is the main cause of high potassium?
Kidney disease is the most prevalent cause of elevated potassium levels. Dehydration is one of the other reasons of elevated potassium levels. Some pharmaceuticals.
How can I test my potassium levels at home?
There are just a few or no alternatives for at-home potassium testing kits on the market today. During the course of the day, you will need to collect urine from wherever you are, including your house, if you have been prescribed a 24-hour urine test.

domain: food


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Outsourcing due to overflow. We are looking for a capable, professional freelancer to redesign our client's logo.
High quality results, preferred .AI vector
Please post your portfolio details.
Current logo available upon request.
14 freelanceria on tarjonnut keskimäärin %project_bid_stats_avg_sub_26% %project_currencyDetails_sign_sub_27% tähän työhön
I am specialist in LOGO designing My own charges of LOGO designing is 500$ but here i can do money is not a problem check it out i will love to do it. Thanks.

domain: design


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Bajaj Finance — cibil not updated
Ssagar24680 on Mar 16, 2018
My consumer id is 56642989. I have a loan as cd for tv, i am paying the loan from dec'17 and paid 4 instalments. However my cibil is still -1, i have contacted you before 2/3 times regarding the same but i am not getting the complete resolution.
As this is the loan means transaction is there with my credit history then why are you not updating it.
Please update my cibil or raise it to the respective person.
|1 Comment Updated:||Share0Tweet0|

domain: economics


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Step Back in Time
Just as it was when Richard Proenneke spent his days living out his dream of unfettered life in the wilderness of Lake Clark National Park and Preserve, the Proenneke cabin sits undisturbed on the shore of Upper Twin Lake for visitors to experience. Marvel at the ingenuity of the hand-crafted cabin and Proenneke's belongings, and learn about his life from park staff during an hour-long tour. For more information about visiting the area, read about the Richard Proenneke cabin in Places to Go.
Remember to bring rain gear and layers for unpredictable weather. Because there may be multiple tours occuring at once the cabin cannot be used as a rain shelter, so expect to be outdoors for much of your visit. Please observe instructions from park staff regarding where meals and picnicking are allowed in the area surrounding the cabin, as there are bears in the vicinity.
THING TO DO
Visit the Richard L. Proenneke Cabin
Tours generally last about an hour.
All ages are welcome.
Yes with Restrictions
Pets are allowed in the park and preserve. However, because Lake Clark is excellent bear and moose habitat it is strongly encouraged that you leave your pets at home. Pets must be leashed at all times.
Entrance fees may apply, see Fees & Passes information.
Upper Twin Lake
Upper Twin Lake is northeast of Port Alsworth, and is not on the road system. The lake can be accessed by float plane from many locations or by boat from Lower Twin Lake.
Reservations are not required to tour the cabin within the operating hours.
Spring, Summer, Fall
The Proenneke Cabin is open to the public daily from late May to late September. You may explore the area year round, but may only enter the cabin in the summer months. The spring opening date of the historic cabin is tentative due to ice melt.
Time of Day
Though you can explore the areas around the cabin at any time, it is only open for the public to enter from 9A.M. to 7P.M. during the summer.
The Richard Proenneke cabin is a short distance from the rock beach that float planes dock on. The path to and around the cabin is several feet wide, gravel, and moderately sloped. The cabin itself requires stepping through a small raised doorway to enter, and the floor of the cabin is gravel as well.
Last updated: October 10, 2017

domain: geography


Elon Muskthe new head of Twitter, restored this Saturday the account of former United States President Donald Trump, banned from the social network after the assault on the Washington Capitol in January 2021.
“The people have spoken,” wrote the tycoon Elon Musk in the social network of which he owns, after the results of a survey launched among his followers.
More than fifteen million responded and 51.8% voted in favor of the “yes” to the return of the politician republican to the platform.
A poll, key point to receive Trump again on Twitter
Of the millions of people who voted in the survey that Elon Musk himself published on his Twitter account, 51.8% approved the reintegration of Donald Trump into the social network, while 48.2% rejected the measure.
- “Reinstate former President Trump,” Musk wrote tersely with only two answer options in the survey, “yes” or “no”.
Musk released the survey late Friday, hours after reinstating several suspended user accounts “in the name of free speech.”
A few minutes after his message, Trump’s account was visible again. The last tweet dates from Jan 8ro of 2021.
Trump does not want to be on Twitter, responded to Musk
In an appearance on video During the Republican Jewish Coalition meeting in Las Vegas, Trump said he welcomed Musk’s poll and that it was his fanbut appeared to reject any return to Twitter, where he had more than 88 million followers.
“I like him, you know, he’s quite a character, and again, I like characters.”
On whether I would return to Twitterwhere she had more than 88 million followers, said: “I don’t consider it because I don’t see any reason for it.”
Why had Twitter taken down Trump’s account?
Twitter had indefinitely suspended Trump on January 8, 2021 at the “risk of further incitement to violence”, two days after his supporters invaded the United States Capitol.
Musk He had already mentioned in May a possible return of the former Republican president, considering that this sanction constituted “an extremely bad and senseless moral decision.”
While many critics fear that the content is no longer moderated enough on the social network, the billionaire has been waiting to speak on the subject.
The decision may cause a stir in much of American society and the political world, especially now that Trump has once again entered the race for the White House by 2024.
AMLO voted for Trump’s return to Twitter
This Saturday, November 19, the president Andres Manuel Lopez Obradorannounced that voted on Twitter in favor of the account of the former US president being restored.
“I already voted for Trump to be able to use Twitter. The Statue of Liberty must not remain an empty symbol.”
Andres Manuel Lopez Obrador.
Twitter had suspended Trump on January 8, 2021two days after the attack by his sympathizers on the Capitolin Washington, given the “risk of further incitement to violence.”


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Kirk Cox Receives Endorsement from State Sen. Emmett Hanger
RICHMOND, VA. — Virginia State Senator Emmett Hanger endorsed Kirk Cox for Governor on Thursday, calling Kirk the candidate most capable of leading and governing on the first day in office. Hanger, who has served in the Senate of Virginia since 1996, represents the 24th Senate District.
Hanger joins State Senators Tommy Norment and Frank Ruff, former State Senators Bill Carrico and Jeannemarie Davis, former Governors George Allen and Bob McDonnell, and over 500 other current and elected officials, and Republican Party leaders who support Kirk.
“I have served alongside Kirk in the General Assembly, and I can tell you what separates him from the other candidates in this race is that while everyone can talk about conservative governing, Kirk is the only one who has actually done it.” said Senator Hanger. “Kirk has defended our shared principles and worked on some of the toughest problems Virginia faces. He brings knowledge and a wealth of experience. More than anyone else in this race, he is actually prepared to govern and lead on day one.”
“We are excited to have Senator Hanger on our team, as we work to build a campaign that can unify not just Republicans, but all Virginians,” said Kirk. “Senator Hanger is a conservative leader, who understands the importance of governing. Democrats, with unified control of Richmond, have simply failed to govern. Our schools were left closed for too long, we were one of the worst state in the nation for COVID-19 and vaccine distribution, and the unemployment system failed people who were struggling and hurting. If Republicans are going to win in November, we’re going to need to show how we can address these issues and get Virginia back on track.”
“Representing the Shenandoah Valley has given me a unique perspective on this Commonwealth,” said Senator Hanger. “There’s a lot more than what people talk about in the halls of Richmond. I think Kirk understands that. He comes from middle-class roots, has experience as a school teacher and a coach, and knows that people are ready for a Governor who listens, understands them, and will work effectively for them.”
Kirk concluded, “Very few people understand Virginia and Virginia government like Senator Hanger, and I will rely on him for advice and ideas throughout this campaign and when I am Governor. I look forward to working alongside Senator Norment, Senator Hanger, and the entire Senate Republican Caucus to win back our majority in 2023.”
For a full list of endorsements announced by the campaign, click here.

domain: news


One-point stereo and 5.1 volume control, source and speaker management
The SPL Surround Monitor Controller (SMC) is a one-point analog volume control and switching matrix for system-independent 5.1 surround and stereo monitoring for essentially any audio application:
- Surround and stereo production
- DVD-V, DVD-A, SACD and DTS authoring
- Film and video postproduction
- Video and game production
- A/V and multimedia production
- Audiophile home entertainment systems
The advantages of the SMC become especially apparent in combination with modern audio and video production tools such as ProTools‚Ñ¢, Nuendo‚Ñ¢, Cubase‚Ñ¢, Logic‚Ñ¢, Deck‚Ñ¢ etc.
One of the SMC's biggest advantages is the possibility to manage several input sources, i. e. for comparing and monitoring SACD or DVD material.


The white paper is the first of its kind to delve into optimization of EAM operations from data collection to data loading. The importance of conducting field asset verification is discussed in addition to how gathering, enhancing, and managing asset data is critical for rigorous spend and maintenance analytics. “Missing, incomplete, and bad data can cause millions of dollars in losses due to unplanned downtime, lost revenues, and regulatory fines,” said Peter Aynsley-Hartwell, global vice president, solutions consulting at Utopia. “Our experience in providing solutions to these problems is embodied in this paper.”
With the right EAM data strategy and methodology an enterprise can dramatically improve the availability of its manufacturing assets, a key factor in long-term success in heavy industries. By assuring data completeness and timeliness, companies can implement better maintenance strategies, cost-effective spare parts provisioning, and vendor-supply chain optimization. These benefits extend to the evolving environmental and regulatory reporting obligations.
“This white paper provides best practices for assuring EAM success with high quality data,” said the author of the paper, Herb Hadley, EAM director of solutions consulting at Utopia. “Further, we show how to collect data from diverse sources, structured and unstructured, using new and innovative methods, and discuss the mechanisms for cleansing and validating the data prior to loading in a company’s EAM system.”
To obtain your copy of Utopia’s new white paper “Mining Hidden Dollars with EAM” visit our site www.utopiainc.com.
“R.A.I.” the Reliability.aiTMChatbot
You can ask "R.A.I." anything about maintenance, reliability, and asset management.


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It’s hard to resist this brilliant bear eye ring with its finely detailed exotic glass eye in a setting of high quality, durable and beautiful 316 stainless steel.
The 10 mm glass bear eye, meticulously handcrafted by a skilled master glass artisan, hearkens to the bear’s spiritual strength and guiding traits.
You are looking for an object of rare beauty and creativity, and Steel Dragon is the only place to find this ring.
Evoke courage and healing spirituality or just wear a museum-quality piece that will enhance your individual look!
Order your life-like bear eye ring right now!
6, 7, 8, 9, 10, 11, 12, 13
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Absolutely attention grabbing with its 14 mm (about 1/2 inch) handcrafted glass eye, our men's ring seems to emit a spiritual and physical healing gleam. The gleaming high-end stainless steel setting is as comfortable to wear as it is impressive to behold.
Printable Ring Sizer

domain: artistic


Jeff became an avid member of the cult he calls ‘contemporary a cappella’ emanating from Sweden and Denmark throughout the world, a more refined style than the US college-based scene. For years he strove to bring this musical style to Israel, together with Ron Gang, head of the national choral organization.
In 2013 Jeff founded Vocalocity, a world-class 40-voice vocal rock band/rhythm choir under the musical direction of Kevin Fox. They have worked with the world’s finest a cappella figures and collaborated with many of Israel’s leading musicians.
“Top shit.”— Peder Karlsson
In 2015 Vocalocity served as chorus in the NotesAre project, in which choral visionary Roger Treece demonstrated composing an a cappella concerto in real-time with virtuoso vocalist Ahinoam Nini (Noa).
“This is the first time I’ve gone nose-to-nose in the ring with a partner from the same weight class.I believe the results are something new and groundbreaking.”—Roger Treece
For decades, Jeff maintained that the universe wouldn’t be in sync until a certain four early Brian Wilson compositions underwent vocal restoration and enhancement. In 2020 he recruited his favorite a cappella arrangers and the other-worldly vocalist Sam Robson to realize his long-nagging dream.
“Brilliant” – Jens Johansen, Vocal Line
“Talented work”— Van Dyke Parks
“As much as I love the source material, these recordings will be my go-to for Brian’s music in full flower, in full, glorious bloom. Something so right, a reminder that visionaries still find the beauty.”—Maggie Evans
A stunning Contemporary Classic a capella composition by Erik Bosio, lyrics by Jeff Meshel.
“Holy moly Jeff. This is powerful beyond beyond. Waves of sound. I hope your heart feels the amazing energy that you put in motion for this beautiful composition.” –Joan Spear, composer
“Absolutely took my breath away! Thanks, Jeff, for being “an instigator, a facilitator, and a minor contributor,” and for sharing this with us!”–Alex Eshed, choral conductor
“This is haunting and beautiful. You forgot to tell us to plug the headphones in! It’s echoing in my mind after the music is complete. Stunning.”–Shari Giddens


This is a wonderful opportunity to create a green space or own a piece of Rochester. Close to shopping, parks and public transportation.
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MINI REVIEW article
Sec. Children and Health
Synthetic and Non-synthetic Cannabinoid Drugs and Their Adverse Effects-A Review From Public Health Prospective
- Behavioral Science, Ariel University, Science Park, Ariel, Israel
There is a growing use of novel psychoactive substances containing synthetic cannabinoids. Synthetic cannabinoid products have effects similar to those of natural cannabis, yet, these drugs are more potent and dangerous, and have been associated with dangerous adverse effects. Here, we review current literature on the epidemiology, acute, and chronic effects of synthetic and natural cannabinoid-based drugs. Synthetic drugs contain a mixture of psychoactive compounds that mostly bind cannabinoid receptors with high potency. These synthetic drugs replicate the effects of natural cannabis and Δ9-tetrahydrocannabinol but they induce more severe adverse effects including respiratory difficulties, hypertension, tachycardia, chest pain, muscle twitches, acute renal failure, anxiety, agitation, psychosis, suicidal ideation, and cognitive impairment. Chronic use of synthetic cannabinoids has been associated with serious psychiatric and medical conditions and even death. Given the growing popularity in the use of cannabinoid-based drugs and their harmful potential, there is a need for further research in this field.
Cannabis is the most widely available and used drug across the world (1, 2). According to the United Nations Office on Drugs and Crime (UNODC) ~4% of the global adult population have used cannabis in their life. In the United States of America (USA) alone, 11% (36 million people) of adults used cannabis at least once in their past (3). In addition, the therapeutic use of cannabis and its derivatives is increasing and has been evaluated for a various health conditions including; pain, anorexia, side-effects of chemotherapy, multiple sclerosis, and muscle spasms (4–6). The primary psychoactive constituent within cannabis is Δ-9 tetra-hydro-cannabinol (THC), which interacts with CB1 and CB2 receptors and it consequently elicits its main effects (7–9). Novel Psychoactive Substances (NPS) which contain Synthetic Cannabinoids (SCs) have recently started to be used recreationally, especially by young adults (10, 11). In contrast to the decline in use of many NPSs such as the cathinones and piperazines, it appears that the number of SC users is increasing (12). Although SC drugs mimic the psychotropic effects of cannabis, their undesired effects are unpredictable and more severe than those associated with cannabis (10, 13–16). Although, there is an increasing interesting on the therapeutic potential of cannabinoid-based medications (6, 17) repeated exposure to cannabinoid-agonists in either organic or synthetic forms is associated with both physically and psychological adverse effects (2, 10, 15, 18). The most notorious psychological side effects are mental disorders including psychotic-states, schizophrenia, and affective disorders (1, 2, 10). The aim of the current review is to describe the available knowledge regarding acute and repeated consumption of both organic and synthetic cannabinoid drugs and their side effects from a public health prospective.
Epidemiology and Pattern of Use of Cannabinoids
According to national and regional representative surveys, lifetime prevalence of SC use in the general population is between 0.2 and 4% (19). By comparison, lifetime use of cannabis tends to be greater; and to range between one-quarter to one-third of the population (1). However, Winstock and Barratt reported that SC products are widely popular among recreational cannabis users (20). Among high school seniors in USA, the annual prevalence of SC usages was higher than any other drugs, with the exception of cannabis (21). Evidence accumulated from several surveys shows that between 6 and 17% of college students in USA have used SC drugs at least once during their study period (22, 23). Other than that, SC use was relatively frequent among adolescents and young-teenagers. Approximately 1% of European people between the ages of 14–18 used SC drugs at least once in their lifetime (24). This is especially important since both clinical and preclinical studies indicate that exposure to SC as well as THC during adolescence is associated with an increased risk of developing schizophrenia later in life (25–27) (see Table 1 for comparison of cannabis and SC adverse effects). Prompted by the alarming growth of the SC drugs phenomenon, legal measures to control the distribution of these drugs have been taken in many countries (57, 58). For example, in the United Kingdom (UK), “first generation” SCs were controlled in 2009 and further legislation to control so-called “second generation” of SCs drugs was enacted in 2013. Yet, subsequent manipulation of the chemical structure of these compounds has resulted in a novel generation of SC's that are not currently legally controlled in the UK (57). Unfortunately, a similar pattern was observed in other countries as well, manufacturers of SCs are aware of the chemical analog loopholes in the law and continue to manipulate SCs as necessary to keep them legal for distribution (26, 57–59). In line with this, a recent epidemiological study by Waugh et al. (57) reported substantial increase in SC drug use in 2011 despite prior legislation efforts. Suggesting, that legislation efforts alone have an insufficient effect on the distribution and use of SC drugs, and further prevention efforts are required to control this phenomenon (57).
Naive consumers typically report using SCs for various reasons, such as curiosity, high availability, easy access, and lower costs compared with cannabis. Since SCs are mostly undetectable via a simple urine test, a major motivation for consuming SC drugs is the desire to experience “cannabis-like” effects without the danger of being detected (11). Other motivations to use SCs are their relatively high availability and low prices (11, 19). In in contrast to cannabis, these synthetic drugs are typically not designed to be mixed with tobacco, probably to achieve the most intense effects (13).
Psychoactive Ingredients of Cannabinoids
The main psychoactive ingredient in cannabis is THC, which is a CB1 and CB2 receptors partial-agonist and the most potent cannabinoid that is present in the organic forms of cannabis (8, 27). Besides THC, organic cannabis products contain additional cannabinoids which do not induce psychoactive effects, such as Cannabinol, Δ8-Tetrahydrocannabinol, and Cannabidiol (CBD) (9, 60, 61). CBD is considered a non-psychoactive cannabinoid that also moderates the psycho tropic effects of THC (32, 62). Moreover, evidence is increasing that CBD has anxiolytic and antipsychotic properties (17, 62). In a broader context, CBD appears to have the ability to counteract psychotic symptoms and cognitive impairment associated with cannabis use as well as with acute THC administration (17, 63–65).
In contrast to cannabis, which contains mostly a mixture of agonist and antagonist cannabinoids (1, 7). SC's compounds show differences in their selectivity, their potency and their function (10, 26, 27, 66), in general they are more potent and efficacious cannabinoid receptor agonists than THC (11, 67). In addition, SC drugs have additional ingredients such as preservatives, additives, fatty acids, amides, esters, benzodiazepines, and O-desmethyltramadol- an active metabolite of the opioid medication tramadol (26, 31, 68). It is suggested that these additional compounds are probably added to these drugs in purposely to induce greater psychoactive effect, act as masking agents to confuse the identification of the main psychoactive substances within these drugs (31, 68).
Since 2008, at least 200 different types of SCs have been isolated from herbal mixtures in several countries (27, 69, 70). This wide variability of psychoactive compounds is probably a result of (a) the impermanent production processes of these drugs, and (b) again their ever-changing compositions in an attempt to dodge prevention and legal actions (31).
One of the earliest compounds that was identified as a psychoactive component in SC drugs is JWH-018. Contrary to THC, JWH-018 has four times the affinity for CB1 receptors and 10 times the affinity for the CB2 receptors (67). Later-on, additional cannabinomimetic compounds such as CP 47,497, cannabicyclohexanol, HU-210, and the fatty acid, oleamide have been detected in samples of SC drugs in different areas around the globe (10, 11). Prior studies examined and indicated the therapeutic potential of SCs; HU-210 proposed to have anti-depressant effects (71), HU-211 proposed to have anti-inflammatory effect on brain trauma (72), and nabilone has antiemetic and analgesic effects (73, 74). However, while these studies report an effect that is induced by exclusive compound, within SC based-drugs, a mixture these cannabinoids as well as additional psychoactive ingredients generates a condition that incudes synergistic interactions which may underline their extrema and unpredicted adverse effects (10, 31).
Adverse Health Effects of Cannabinoids
Acute Effects of Cannabinoids
The intoxication effects of cannabis are characterized by cannabis users as; mild euphoria, relaxation, and a general pleasant feeling (1, 7). These desired psychotropic effects are considered to be related to the presence of THC (8, 9). In laboratory settings, cannabis and THC induce dose-related impairment in several functions including; motor coordination and executive function (38, 75–78).
Further undesired symptoms including anxiety, panic attacks, and psychotic episodes were associated with cannabis intoxication, all of which are most often reported by naïve users and vulnerable individuals (56, 79). Similar to cannabis, the intoxication of SCs may induce reactions such as relaxation, euphoria, perceptual alteration, altered sense of time, and mild cognitive impairments (80).
These cognitive alterations increase the risk of road accidents if cannabis or SC users drive while intoxicated (1, 15). Epidemiological evidence demonstrates that cannabis is the most common illicit drug to be detected in drivers involved in fatal road accidents or stopped for dangerous driving (1). Accordingly, cannabis use by drivers is associated with an increased risk of being involved in motor vehicle crashes (81). There is less epidemiological data on the association between SC drugs and road accidents, yet, several case studies have documented driving under influence of SCs. Musshoff et al. reported 8 drivers in Germany that were stopped by police for reckless driving. Several types of SCs were identified in all suspected serum samples, drivers showed slow responses, retarded movements and an impairment of fine motor skills (52). Yeakel and Logan described 12 cases of driving under the influence of SCs, in all cases drivers presented a generally poor motor coordination (53). In a Norwegian study conducted during a 7-week period, about 2.2% of 726 blood samples that were collected from drivers that were suspected to drive under the influence of drugs, confirmed positive for SCs and majority of the drivers were involved in vehicle accidents (54). Taken together it seems that as with driving under the influence of cannabis (1, 81), driving after SCs may also increase the risk of being involved in road accidents (10, 15).
Despite the resemblances, there are major differences between the effect of cannabis and SC drugs, both in terms of spectrum and intensity of these effects (13). Case report studies indicate a wide range of undesired somatic effects ranging in intensity from nausea to more severe symptoms such as psychomotor agitation, diaphoresis, and palpitations (13, 29). Some symptoms such as seizures; agitation, hypertension, emesis, and hypokalemia are features of SC intoxication and are not present even after consuming high doses of organic cannabis (29, 31, 33).
Psychotropic effects of SC intoxication vary significantly. Some users report a feeling of sedation while others experience agitation, fatigue, and flushes (29). This variation may occur due to different concentrations of SCs within different brands (27). Compared with the intoxication of organic cannabis products which have a slow effect and gradually fade (7, 82), SCs have a shorter duration and peak earlier (83). For example, the effects of JWH-018 last approximately for 1–2 h, while CP-47,497 induce effects for ~5–6 h (20). Moreover, some adverse effects such as anxiety, hallucinations, insomnia, and psychotic episodes may be experienced for days and weeks after consuming SC products (84).
Chronic Effects of Cannabinoids
Several studies demonstrate an association between repeated cannabis use and long-lasting cognitive impairments (2, 39, 85, 86), and an increase in risk for developing a variety of mental disorders. These include anxiety (34, 35), bipolar disorder (36), depression (37), and schizophrenia (2, 25, 32). There is growing evidence that SC drugs are associated with severe negative psychiatric and medical conditions (10, 15, 29, 31). This evidence demonstrates that repeated exposures to SCs induce overall negative side-effects which are more severe and long-lasting than those related with THC (10, 15, 29, 31).
A recent study by Cohen et al. shows deficiencies in a variety of high-order cognitive functions observed among SC users compared with recreational cannabis users including working memory, attention and recall (18). Another study indicates that SC users who had acute psychotic disorder induced by SC drugs, show cognitive impairments similar to those of schizophrenic patients (87). These results are compatible with evidence from rodent studies that show that repeated exposures to SCs induces long-lasting behavioral and cognitive impairments that resemble rodent models of schizophrenia (88, 89).
There is evidence indicating adverse effects of cannabis on cardiovascular function (1, 44, 46). Studies demonstrate that cannabis use can increase the risk of serious cardiovascular condition, including artery thrombosis, vasospasm, and myocardial infarction (90). Cannabinoid agonists, as well as THC, increase heart rate in a dose-dependent manner (1). Therefore, it is likely that these effects are mediated through cannabinoid-agonist's increase in catecholamines and increased cardiac workload together with a decreased supply of oxygen (91). Since SC drugs contain psychoactive compounds which have much higher affinity at CB1 receptors (67), it is not surprising that there are several reports that indicate an association between SC use and serious cardiovascular problems such as myocardial infarction and tachycardia in both adults and adolescents (92, 93).
Cannabinoids and Psychosis
The association between cannabinoids and psychosis is reported and it is well-recognized (2, 77, 79, 94), yet, casual relations between these two factors were not established (2, 79). However, converging evidence suggests that cannabis use has the potential for inducing psychosis (31, 77, 79, 95–98). SC products contain compounds which act as highly potent CB1 and CB2 full agonists, and in contrast to natural cannabis, contain no CBD (27, 31, 79). Due to the psychoactive features of SC drug ingredients it is not surprising that there are numerous reports on healthy and vulnerable individuals who suffer from recurrent psychosis after an acute or repeated consumption of SC drugs (15, 45, 99). Recent reports in Europe suggest that 15% of SC users who report to emergency departments present psychotic symptoms (100). These figures are far greater compared to those using other types of psychoactive substance (100). In addition, compared with cannabis, psychotic symptoms that are associated with SC are more severe and gross, in some cases they can even last for weeks following last use (10, 99).
Effects of Cannabinoids on the Central Nervous System
A large number of recent studies present a range of functional and structural neuronal abnormalities associated with regular use of cannabis (32, 49, 50). Generally, cannabis users show volumetric, gray matter, and white matter structural changes in the brain, particular within limbic and prefrontal areas (49, 50, 101). In addition, pharmacological studies draw a link between cannabis use and alterations of dopamine synthesis (102). Greater dose of THC, and an earlier age of onset area associated with these neuronal alterations (2, 32).
Compared with cannabis, there are fewer brain imaging studies exploring the neural correlates of SC use. Nurmedov et al. compared 20 males who used SC products with 20 healthy control participants and reported that SC users showed smaller gray-matter volume in the thalamus and the cerebellum (47). Recently, Zorlu et al. found a reduction of white matter volumes in several brain regions including the left temporal lobe and subcortical structures among SC users (48). In another single case study, a young SC user reported severe symptoms induced following a voluntary abstinence from SC drugs. In this patient, dopamine D2 and D3 receptors availability was lower in the striatum and in extra-striatal regions in comparison with healthy control participants during abstinence but it recovered after treatment (103). These initial studies highlight some the neurotoxic potential of SC products but since they are still preliminary. Further research is warranted.
Health Hazards and Withdrawal
In contrast to cannabis, the use of SC has been associated with severe hazardous health effects on multiple systems and with death (28, 104, 105). During the last 8 years in the United Kingdom, there were 510 reports associated with SC use that required urgent medical intervention (57). In USA there were 37,500 reported cases of seizures and 3,682 reported cases of poisonings related to SC use during 2014 (106). In addition, while there is no available documentation on an overdose death as a result of cannabis use (1), there are numbers of reports indicating a fatal outcome following consumption of SC drugs. Tait et al. identified at least 26 cases of individuals who used SC products and exhibited side-effect complications that have led to their death. The major complications were cardiovascular events, respiratory depression, pulmonary complications and acute kidney injury (107). Prolonged consumption of SC is associated with serious withdrawal symptoms including; agitation, irritability, anxiety, and mood swings (43). Some of these symptoms are similar to cannabis, yet, the differences in presentation may reflect the presence of extraneous psychoactive compounds, including amphetamine-like stimulants, and the high affinity of these SCs (45, 43).
Cannabinoid based drugs became increasingly popular despite the risks associated with their use (31, 45, 57). While the psychotropic effects associated with natural cannabis are related to the presence of THC (1), SC products contain a wide range of high-potent full agonists of the cannabinoid receptors that induce “THC-like” effects, but they are more severe and enduring (10, 15, 29, 31). While cannabis use usually induces psychotropic effects such as euphoria, relaxation, and a general pleasant feeling, it is associated with severe side-effects (1). The use of SC drugs is associated with more undesired effects including; agitation, irritability, confusion, hallucinations, delusions, psychosis, and death (28, 104, 105).
Chronic use of SC is associated with a greater risk for developing serious mental health disorder than cannabis or other psychoactive substances (100). Chronic use of cannabinoids is associated with structural and functional neuronal alterations (15, 32, 49), these alterations are moderated by the age of onset and the type of cannabinoids (32). This is crucial since the use of SC drugs is widely popular among young adults and teenager (10, 11). In addition, legal measures to control the use of SCs are reported as not effective enough to diminished the use of these drugs (26, 31, 106, 108), thus, further prevention programs should be conducted (31). Prevention programs to control SC drugs use and distribution may be based on information communication technology (ICT) tools and target young adults and students (109–111). Initial research regarding the efficiency of ICT-based prevention programs indicated on promising results in monitoring and control NPS use and distribution (109, 111). In conclusion, SC drugs show greater toxicity than organic cannabis, and therefore further investigation of their long-lasting and acute adverse effects is required as well as better detection and controlling measures against the spread of the use of SC products.
All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.
The study was funded by the National Institute for Psychobiology in Israel.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
We would like to thank Shlomo Tekuzener for linguistic editing of the article.
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70. Uchiyama N, Kikura-Hanajiri R, Ogata J, Goda Y. Chemical analysis of synthetic cannabinoids as designer drugs in herbal products. Forens Sci Int. (2010) 198:31–8. doi: 10.1016/j.forsciint.2010.01.004
71. Hill MN, Gorzalka BB. Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test. Eur Neuropsychopharmacol. (2005) 15:593–99. doi: 10.1016/j.euroneuro.2005.03.003
72. Shohami E, Novikov M, Bass R. Long-term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory functions after closed head injury in the rat. Brain Res. (1995) 674:55–62. doi: 10.1016/0006-8993(94)01433-I
75. Asmaro D, Carolan PL, Liotti M. Electrophysiological evidence of early attentional bias to drug-related pictures in chronic cannabis users. Addict Behav. (2014) 39:114–21. doi: 10.1016/j.addbeh.2013.09.012
77. D'Souza DC, Perry E, MacDougall L, Ammerman Y, Cooper T, Wu Y, et al. The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis. Neuropsychopharmacology (2004) 29:1558–72. doi: 10.1038/sj.npp.1300496
78. Gorelick DA, Goodwin RS, Schwilke E, Schwope DM, Darwin WD, Kelly DL, et al. Tolerance to effects of high-dose oral Δ9-tetrahydrocannabinol and plasma cannabinoid concentrations in male daily cannabis smokers. J Analyt Toxicol. (2013) 37:11–6. doi: 10.1093/jat/bks081
82. Ramaekers JG, Kauert G, Theunissen EL, Toennes SW, Moeller MR. Neurocognitive performance during acute THC intoxication in heavy and occasional cannabis users. J Psychopharmacol. (2009) 23:266–77. doi: 10.1177/0269881108092393
83. Fantegrossi WE, Moran JH, Radominska-Pandya A, Prather PL. Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ 9-THC: mechanism underlying greater toxicity? Life Sci. (2014) 97:45–54. doi: 10.1016/j.lfs.2013.09.017
84. Papanti D, Schifano F, Botteon G, Bertossi F, Mannix J, Vidoni D, et al. “Spiceophrenia”: a systematic overview of “Spice”-related psychopathological issues and a case report. Hum Psychopharmacol. (2013) 28:379–89. doi: 10.1002/hup.2312
85. Bossong M, Jager G, Bhattacharyya S, Allen P. Acute and non-acute effects of cannabis on human memory function: a critical review of neuroimaging studies. Curr Pharm Des. (2014) 20:2114–25 doi: 10.2174/13816128113199990436.
87. Altintas M, Inanc L, Oruc GA, Arpacioglu S, Gulec H. Clinical characteristics of synthetic cannabinoid-induced psychosis in relation to schizophrenia: a single-center cross-sectional analysis of concurrently hospitalized patients. Neuropsychiatr Dis Treat. (2016) 12:1893. doi: 10.2147/NDT.S107622
88. Bambico FR, Nguyen NT, Katz N, Gobbi G. Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission. Neurobiol Dis. (2010) 37:641–55. doi: 10.1016/j.nbd.2009.11.020
89. Renard J, Krebs MO, Jay TM, Le Pen G. Long-term cognitive impairments induced by chronic cannabinoid exposure during adolescence in rats: a strain comparison. Psychopharmacology (2013) 225:781–90. doi: 10.1007/s00213-012-2865-z
90. Jouanjus E, Raymond V, Lapeyre-Mestre M, Wolff V. What is the current knowledge about the cardiovascular risk for users of cannabis-based products? A systematic review. Curr Atheroscl Rep. (2017) 19:1–15. doi: 10.1007/s11883-017-0663-0
92. Barceló B, Pichini S, López-Corominas V, Gomila I, Yates C, Busardò FP, et al. Acute intoxication caused by synthetic cannabinoids 5F-ADB and MMB-2201: a case series. Forensic Sci Int. (2017) 273:10–14. doi: 10.1016/j.forsciint.2017.01.020
93. McIlroy G, Ford L, Khan JM. Acute myocardial infarction, associated with the use of a synthetic adamantyl-cannabinoid: a case report. BMC Pharmacol Toxicol. (2016) 17:1–4. doi: 10.1186/s40360-016-0045-1
95. Bioque M, Cabrera B, García-Bueno B, Mac-Dowell KS, Torrent C, Saiz PA, et al. Dysregulated peripheral endocannabinoid system signaling is associated with cognitive deficits in first-episode psychosis. J Psychiatr Res. (2016) 75:14–21. doi: 10.1016/j.jpsychires.2016.01.002
96. Bloomfield MAP, Morgan CJA, Egerton A, Kapur S, Curran HV, Howes OD. Dopaminergic function in cannabis users and its relationship to cannabis-induced psychotic symptoms. Biol Psychiatry (2014) 75:470–8. doi: 10.1016/j.biopsych.2013.05.027
100. Vallersnes OM, Dines AM, Wood DM, Yates C, Heyerdahl F, Hovda KE, et al. Psychosis associated with acute recreational drug toxicity: a European case series. BMC Psychiatry (2016) 16:293. doi: 10.1186/s12888-016-1002-7
101. Yücel M, Solowij N, Respondek C, Whittle S, Fornito A, Pantelis C, et al. Regional brain abnormalities associated with long-term heavy cannabis use. Arch Gen Psychiatry (2008) 65:694–701. doi: 10.1001/archpsyc.65.6.694
103. Rominger A, Cumming P, Xiong G, Koller G, Förster S, Zwergal A, et al. Effects of acute detoxification of the herbal blend “Spice Gold”on dopamine D 2/3 receptor availability: a [18 F] fallypride PET study. Eur Neuropsychopharmacol. (2013) 23:1606–10. doi: 10.1016/j.euroneuro.2013.01.009
106. Keyes KM, Rutherford C, Hamilton A, Palamar JJ. Age, period, and cohort effects in synthetic cannabinoid use among US adolescents, 2011–2015. Drug Alcohol Depend. (2016) 166:159–67. doi: 10.1016/j.drugalcdep.2016.07.018
107. Tait RJ, Caldicott D, Mountain D, Hill SL, Lenton S. A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatment. Clin Toxicol. (2016) 54:1–13. doi: 10.3109/15563650.2015.1110590
108. Bilgrei OR. From “herbal highs” to the “heroin of cannabis”: exploring the evolving discourse on synthetic cannabinoid use in a Norwegian Internet drug forum. Int J Drug Policy (2016) 29:1–8. doi: 10.1016/j.drugpo.2016.01.011
109. Corazza O, Schifano F, Simonato P, Fergus S, Assi S, Stair J, et al. Phenomenon of new drugs on the Internet: the case of ketamine derivative methoxetamine. Hum Psychopharmacol. (2012) 27:145–9. doi: 10.1002/hup.1242
110. Corazza O, Assi S, Trincas G, Simonato P, Corkery J, Deluca P, et al. Novel Drugs, Novel Solutions: exploring the potentials of web-assistance and multimedia approaches for the prevention of drug abuse. Italian J Addict. (2011) 1:25–30.
111. Corazza O, Simonato P, Corkery J, Trincas G, Schifano F. “Legal highs”: safe and legal “heavens”? A study on the diffusion, knowledge and risk awareness of novel psychoactive drugs among students in the UK. Riv Psichiatria (2014) 49:89–94. doi: 10.1708/1461.16147
Keywords: cannabis, synthetic cannabinoids, novel psychoactive drugs, drug abuse, addiction
Citation: Cohen K and Weinstein AM (2018) Synthetic and Non-synthetic Cannabinoid Drugs and Their Adverse Effects-A Review From Public Health Prospective. Front. Public Health 6:162. doi: 10.3389/fpubh.2018.00162
Received: 09 January 2018; Accepted: 14 May 2018;
Published: 07 June 2018.
Edited by:Blair Henry, Sunnybrook Health Science Centre, Canada
Reviewed by:Mandakini Sadhir, University of Kentucky, United States
Daniel Rossignol, Rossignol Medical Center, United States
Copyright © 2018 Cohen and Weinstein. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Aviv M. Weinstein, email@example.com

domain: medical


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Shantung Sentence Examples
It was seized in November 1897 by the German fleet, nominally to secure reparation for the murder of two German missionaries in the province of Shantung.
The Wei dynasty, to which Tsaou-tsaou belonged, reigned in northern China, and at this day a considerable manufacture of glass is carried on at Po-shan-hien in Shantung, which it would seem has existed for a long period.
At various times it has discharged its waters alternately on one side or the other of the great mass of mountains forming the promontory of Shantung, and by mouths as far apart from each other as 500 m.
Since 1887 there have been a series of smaller outbreaks, mostly at points lower down and in the neighbourhood of Chinanfu, the capital of Shantung.
When war broke out between China and Japan in 1894, he was appointed commander in-chief of the second Japanese army corps, which, landing on the Liaotung Peninsula, carried Port Arthur by storm, and, subsequently crossing to Shantung, captured the fortress of Wei-hai-wei.Advertisement
For thirteen years of his life Confucius wandered about from state to state, seeking rest and patrons; but his journeyings were confined within the modern provinces of Ho-nan and Shantung, and the borders of Chih-li and Hu-peh.
The fabric choices for shades are much more decorative and refined, such as Shantung silks and crinkled, oiled papers.
That dress is white shantung silk, with a cream coat.
The fabric choices for shades are much more decorative and refined, such as shantung silks and crinkled, oiled papers.
Tussah and Shantung silks are made from the cocoons of wild silkworms.Advertisement
One way this is done is by using a less expensive fabric, like polyester shantung or satin, in the manufacturing process instead of expensive fabrics like silk.
The majority of the signature bags are made with shantung (heavy and sturdy), jacquard (artistic scroll embossed into the fabric) or sateen (slightly shiny).


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Third party DRM: SteamThis game requires a free Steam account to play.
"Remedy's done a great job of mixing elements of written work, television, and video games to create an experience full of scares, laughs, and thrills that's just as fun to play as it is to watch." - IGN.com
"...it’s still a genuinely skin-twitching survival game with an original and tense twist to the combat." - PCgamer.com
The critically acclaimed and BAFTA nominated, TIME magazine Game of the Year Alan Wake, finally comes to PC! From Remedy, the creators of Max Payne arrives a heart pounding Psychological Action Thriller, further refined and enhanced for the PC. The game comes with two special episodes, The Signal and The Writer.
About the Game
When the wife of the best-selling writer Alan Wake disappears on their vacation, his search turns up pages from a thriller he doesn’t even remember writing. A Dark Presence stalks the small town of Bright Falls, pushing Wake to the brink of sanity in his fight to unravel the mystery and save his love.
Presented in the style of a TV series, Alan Wake features the trademark Remedy storytelling and pulse-pounding action sequences. As players dive deeper and deeper into the mystery, they’ll face overwhelming odds, plot twists, and cliffhangers. It’s only by mastering the Fight With Light combat mechanic that they can stay one step ahead of the darkness that spreads across Bright Falls.
With the body of an action game and the mind of a psychological thriller, Alan Wake’s intense atmosphere, deep and multilayered story, and exceptionally tense combat sequences provide players with an entertaining and original gaming experience.
Enhanced for the PC
• Includes Alan Wake Special Episodes “The Signal” and “The Writer”.
• Experience Alan Wake’s Pacific Northwest in higher resolutions and higher fidelity than the Xbox360 version.
• Fully configurable mouse and keyboard support, or if you prefer to play with the Microsoft gamepad connected to your PC, you can do that too!
• Lots of customizable graphics settings and support for 4:3, 16:9 and 16:10 aspect ratios!
• Multithreaded engine that takes advantage of quad core CPUs.
• Additional features our fans have sought after such as field of view adjustment as well as “hide HUD”.
• Works with AMD Eyefinity 3D 3-screen mode.
• Works with NVIDIA NVISION2 Stereoscopic 3D.
Good story - Average gameplaybritishlad | May 10, 2013 | See all britishlad's reviews »
From the makers of Max Payne comes Alan Wake - The story is the main draw of this game. It is excellent, and somewhat reminiscent of Stephen King, if you're into that at all. The music, graphics and voice acting are all excellent!
However the actual combat is nothing really special, and can get frustrating at times (especially one part involving a bulldozer). It is also linear and the combat and get repetitive after a while. It's still a good and interesting experience but it terms of gameplay there is very little replay value....
An amazing adventure!Laudes | May 4, 2013 | See all Laudes's reviews »
I'm a adventure player, I enjoy those really good adventure games. However I am not a big fan of buying AAA games all the time that has the mark "Adventure" on the side. This game is a true adventure with a thrilling story.
The combat is very innovative and it was far more enjoyable then the standard point - click - kill enemies. I found the game extremely hard, however when I had completed the game I got an achievment for playing the game on Hard! Well with that being said, if you're looking for a challenge the Hard difficulty setting sure is hard, however not impossible.
I found myself running around doing about nothing just to get to a place where I had to be at, which I got a little bit frustrated about. Of course, every game is more or less like that, they add small things to make the game last longer. The game wasn't that long anyway, it took me 11 hours to complete it. Of course it has a TON of replayability with all the cofee-cans and manuscript pages, and God knows what you can collect!
The TV shows and small extras around the game is interesting at times, but in total I would say those are also just a waste of time to make the game last longer for people interested in such. But, other games like Deus EX and Skyrim, all has for example emails and books to read throughout the world. Think of these TV-Shows and radio programs as such, but a little bit more interesting I would say.
A must buy for adventure players! The soundtrack is great aswell, lots of good music.
Has its momentslehemake | April 30, 2013 | See all lehemake's reviews »
Alan Wake is a 3rd person view action-horror game with a spooky story. Famous writer fights its way against the Darkness to save his kidnapped wife in little town of Bright Falls. The main story has 6 cinematic style episodes and two bonus episodes continuing story. There's about 12-15 hours of gameplay (which was enough for me). First episodes are somewhat dull and repetitive - running through woods and killing enemies. The scenery offers boring trees and rocky paths at the beginning but later episodes give more variety and different places around Bright Falls and bonus episodes are insane remixes of main story and thus fun, interesting level design.
The game has (too) much fighting with enemies. Besides the most important "weapon", flashlight, Alan can use guns and flash grenades. Pointing flashlight toward enemies and then shooting them is the way to survive against ambushes of "the taken". Also keeping distance and dodging attacks are important maneuvers to do. And there are no melee weapons, regrettably. Enemies tend to spawn when the darkness lands and sometimes its better to ignore mobs and run towards light (usually checkpoint) than waste time by fighting. Exploration isn't very inspiring at this game because the level design is very linear and all you may find is some collectible coffee thermoses or ammo stashes which maybe needed but getting those usually tend spawn some enemies nearby. NPCs are well done in game. Their dialogue is usually good, even funny and they can defend themselves at action sequences so you don't have worry about stupid AIs.
Usually graphics and audio are well done so the atmosphere is fine during the game but the cinematic scenes are blurry and outdated that could have been much better looking just rendering by the game's own graphics engine.
Recommended bargain buy.
Quite fun!acloggedtoaster | April 30, 2013 | See all acloggedtoaster's reviews »
A surprisingly creepy game! The opening is very intense, and never loses the survival horror theme that so many "survival horror" games of this generation fail to capture. The only real problem is that it is a mediocre pc port and that for weaker rigs, Anti aliasing must always be turned on, hammering frames per second. visuals do look quite nice! Would recommend!
A Great Game with Few FlawsAgerion | April 27, 2013 | See all Agerion's reviews »
The developers of this game weren't just looking for a way to make extra cash by porting it from it's home consoles to PC, this game really takes the PC Power and pumps what it can into the game. The fighting mechanic is tense and exciting since you must keep track of both your ammo and battery on your flashlight and all enemies are invulnerable until the darkness has been burned off of them. The game plays out like a TV show which is a big plus for College Students like myself. You play through an episode, it wraps up nice and tight, and when you come back next week you get a recap of what happened. This can be a problem for those gamers looking to complete the game in a single sitting, however. That coupled with the fact that, in cinematic, facial animations are comically stiff, are the only gripes I had with the game. Alan Wake is worth both your time and money.

domain: hobby


text:
(Source: reverberating-footsteps, via fiingerling)
Drugs and long nights
"I had love once in the palm of my hand.
See the lines there."
- John Wieners, from “A Poem for Painters” (thanks, deskofalex)
Don’t know why I miss you so much.
Need to chill with the purchasing
(Source: bvsedjesus, via snackcitytrick)
Feelin creative tonight


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MDC leader Nelson Chamisa has made sensational claims President Emmerson Mnangagwa was sending state agents and some military intelligence operatives to tail him even when he goes to the toilet.
He was addressing a crowd estimated to be slightly above 3 000 party followers who thronged his Marondera “Thank You” rally at Rudhaka Stadium on Saturday.
Chamisa, who came a close second to President Mnangagwa in the July 30 elections, has lined up the countrywide rallies to thank Zimbabweans who voted him even though the outcome did not usher him into State House.
In his address, Chamisa, also a pastor, said Mnangagwa was sending spooks to follow him everywhere he went and even to mountains where he often retreats to engage in prayer.
“Your (Mnangagwa) CIO and Military Intelligence operatives are after me,” Chamisa said.
“They are following me even into toilets and in church gatherings. Yesterday (Friday) they followed me to Domboshava where l had gone to the mountains to pray.
“They block my men everywhere…Mnangagwa is worse than Mugabe himself. He is a worse dictator than the old man himself.”
Chamisa said he was not afraid of death.
The MDC leader, who continuously claims he was robbed of his victory by the Zanu PF strongman, urged Mnangagwa to accept “defeat” and to also seek him for advice.
In the recent past, Chamisa threatened to lead countrywide demonstrations to force Mnangagwa to step down.

domain: politics


text:
Welcome to Red Ruby Art Gallery 2022 Updates
Here are some of our Custom services
- Handcrafted rustic picture frames to order.
- Custom cut to size Matte board.
- Picture frame glass cutting
- Custom handcrafted and designed shadow boxes.
- Hand painted sign lettering and pinstriping/outlining.
- Window decal design and installation.
- Custom order T-Shirts
- Party or group Sign painting classes.


text:
Best online dating profiles female serial killers
5, derrick Todd Lee, t know that there were any female serial killers by what you see on the news. Torture Kill or BTK killer grew up in healthy households with supportive family members. In private, for actfocused killers, in the, qafzeh real Crime and Dr Yardley said. Doctor Harold Shipman, ashton Kutcher, aileen Wuornos was a female serial killer who murdered. Ted Bundy, aN egotistical bragger, however, even when theyve been caught and know the game. This makes them unlikely to conform to social norms. Before being arrested, this highlights the differences in the types of killers. And occasionally violence to control others. Said he would encourage violence against other ren even at school. Some of the worlds best known serial killers have. Irritable and aggressive and lack of remorse. So from holmes now on can we just assume that pcycotic people come from both genders and neither gender is the morally superior. Psychosis is when a person loses sense of reality. Or pretending to be a policeman or person of authority. Some of the worlds best known serial killers have a frightening ability to manipulate those around them. Brain scans of rapist and serial killer Brian Dugan showed a lack of activity in the regions associated with empathy and remorse. Hopefully you will all have fun meeting singles and try out this online dating.

domain: sociology


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The Trump administration is optimistic about concluding a trade deal with Japan, which may be formally announced this month, said White House economic adviser Larry Kudlow.
President Donald Trump and Japanese Prime Minister Shinzo Abe are scheduled to hold a one-on-one meeting Sept. 25 during the UN General Assembly in New York, Kudlow said Tuesday.
“There just might be an announcement at the United Nations,” Kudlow told the U.S.-Japan Business Conference in Washington. “You can never tell, but I’m an optimist.”
Trump on Monday said that his administration had struck a partial trade accord with Japan on tariff barriers and digital trade, and the sides are expected to enter into the agreement in the “coming weeks.”
The president, however, didn’t make clear whether he’d end the threat of slapping steep auto tariffs on Japan -- a key reason that Tokyo wanted to negotiate with the U.S. from the outset of talks that began last year.
Japanese Foreign Minister Toshimitsu Motegi, the country’s point man for the trade talks, said on Tuesday that Tokyo wanted the Trump administration to end the threat of new auto tariffs before agreeing to a final trade deal. “We are aware of the internal process that is going on in the U.S. and the president’s notice of the U.S.-Japan trade negotiations,” Motegi told reporters in Tokyo.
Trump announced the initial agreement in a notice to Congress, though he doesn’t require the approval of lawmakers to implement the deal.
U.S. Chamber of Commerce Chief Executive Officer Thomas Donohue, speaking at the same event as Kudlow, said business leaders are urging the administration to keep its focus on securing a “comprehensive high-standard trade agreement with Japan in the near future.”
Trump said Monday that the U.S. still planned to pursue further negotiations for a far-reaching U.S.-Japan agreement in the future.
“We need to make sure this initial package is a step in that direction,” said Donohue. “A comprehensive trade deal with Japan will provide some badly needed predictability -- not only with the U.S. and Japan, but for our trade allies.”
On the prospects of a U.S.-China trade deal, Kudlow said the mood has turned more optimistic. “There’s a little music in the air, which is not always so but right now, we should enjoy the day,” Kudlow said.
U.S.-China trade deputies are meeting Thursday and Friday in Washington and trade principals from the two countries will be meeting in mid-October to continue talks, he said.
© Copyright 2023 Bloomberg News. All rights reserved.


text:
Fruit of grisaia cuties fruit
The groves make Mr. Evans the king of the Cuties, a brand of seedless, sweet and easy-to-peel mandarin that is storming the nation's fruit Missing: grisaia. The oldest citrus fruits we know about are the mandarin, the pomelo (sometimes Cuties, Pixies, Delites: How Marketing Rebranded a read-books-online.infog: grisaia. In , Sun Pacific began planting Spanish Mandarin trees south of Bakersfield, CA and named the perfect little fruit Cuties. Attributes: Small and Sweet Missing: grisaia. Reblog. 6. Characters of Grisaia no Kajitsu. yushiyuki · Follow. Unfollow · grisaia no kajitsule fruit de la grisaiagrisaia no kajitsu gifmakina irisuirisu makinasuou. Grisaia Grisaia no Kajitsu Sakaki Yumiko Matsushima Michiru. Fruit of Grisaia - Michiru. Grisaia no Kajitsu. Grisaia no Kajitsu. Facebook으로 로그인. He is my favourite character in fruit of grisaia. Popular Pages Ｂｌｕｅ ｈｅａｄ ｃｕｔｉｅ. Ｂｌｕｅ ｈｅａｄ ｃｕｔｉｅ. ┇The Imuchakk waifu┇ Here's another smol.


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Beta Beta Chapter (Maryland)
Beta Beta Chapter was installed at the University of Maryland in College Park, Maryland, on October 23, 1940. Beta Beta Chapter was closed on May 8, 2000, and was reinstalled on May 7, 2016.
Frances Ide Johnson (Goucher, 1928), a faculty member at the University of Maryland, assisted by several Gamma Phi Beta transfer students colonize a group on this campus. Their petition was approved after inspection by Grand President* Alice Wieber Fitzerald (Michigan, 1913) and the group was initiated at Convention 1940 in Washington, D.C. At this time, two wives of Congressmen, Mrs. Wilbur Cartwright and Mrs. Millard Tydings, were initiated as alumnae. On October 23, the first Initiation was held in the chapter facility on the University campus and 15 members were installed by Mrs. Fitzgerald as charter members of Beta Beta Chapter (Maryland).
*Grand President is now known as International President.
Beta Beta Chapter’s new initiates in 1940.

domain: history


This project was born because I have been building my own quadcopters for a few years now and I wanted to use my experience in this field to build another type of radio-controlled machine. I wanted to build something bigger than a drone while adapting the basic components of a radio control vehicle (motors, electronic speed controllers, receiver and radio transmitter and batteries.). Having done quite a lot of skateboarding in my teenage years, I quickly considered the feasibility of propelling skateboard thanks to the electronic components that I used to use. Having to find similar projects and the necessary components, I have to realize all the prototyping in 3D printing. I launched version 1 of my project “PEX Board” at the end of July 2017, and I now intend to realize a series of improvements and mods to propose different configurations and extend the possibilities of this open-source electric skateboard.
I among other things to make a waterproof version with larger off-road wheels for the winter. I live in Canada… and I don’t want to wait 6 months to ride 🙂
The fun part of the project is that you can print it if you want (by using your own 3D printer, by looking for local printers on 3Dhubs.com or by ordering me the parts directly.) you can build it without any soldering if you want and once you have sourced all the parts, it can be build and configurated in a weekend. I have published a tutorial to explain how to build it from A to Z.


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The Little Hours fuses arthouse cinema with modern comedic stylings borrowed from Judd Apatow’s toybox. In other words, it’s a film with lovely cinematography and patient pacing, yet features bawdy behaviour and provocative profanity.
John C. Reilly
One of the most exciting voices of contemporary cinema has hit that point in his career where he needs to make his first English language feature. Thankfully, unlike countless others before him, Yorgos Lanthimos managed to avoid the usual pitfalls of the “first English feature” and results in The Lobster, a film as weird and brilliant as his previous features Dogtooth and ALPS.
By: Addison Wylie The award for this year’s most awkward movie goes to Rick Alverson’s Entertainment, a film rooted in morose career purgatory. Now, the last time I used the term “career purgatory”, it was when I reviewed Lenny Abrahamson’s delightful Frank. Frank presented the argument that an artist stuck in a creative rut isn’t necessarily the end of the world. Entertainment proposes a sardonic rebuttal with a comedian (played by real-life alternative comic Gregg Turkington)…

domain: entertainment