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The History of IVF -The Milestones
The history of In Vitro Fertilization (IVF) and embryo transfer (ET) dates back as early as the 1890s when Walter Heape a professor and physician at the University of Cambridge, England, who had been conducting research on reproduction in a number of animal species, reported the first known case of embryo transplantation in rabbits, long before the applications to human fertility were even suggested.
In 1932, ‘Brave New World’ was published by Aldous Huxley. In this science fiction novel, Huxley realistically described the technique of IVF as we know it. Five years later in 1937, an editorial appeared in the New England Journal of Medicine (NEJM 1937, 21 October) which is note worthy.
"Conception in a watch glass: The ‘Brave New World’ of Aldous Huxley may be nearer realization. Pincus and Enzmann have started one step earlier with the rabbit, isolating an ovum, fertilizing it in a watch glass and reimplanting it in a doe other than the one which furnished the oocyte and have thus successfully inaugurated pregnancy in the unmated animal. If such an accomplishment with rabbits were to be duplicated in the human being, we should in the words of ‘flaming youth’ be ‘going places.’"
In 1934 Pincus and Enzmann, from the Laboratory of General Physiology at Harvard University, published a paper in the Proceedings of the National Academy of Sciences of the USA, raising the possibility that mammalian eggs can undergo normal development in vitro. Fourteen years later, in 1948, Miriam Menken and John Rock retrieved more than 800 oocytes from women during operations for various conditions. One hundred and thirty-eight of these oocytes were exposed to spermatozoa in vitro. In 1948, they published their experiences in the American Journal of Obstetrics and Gynecology.
However, it was not until 1959 that indisputable evidence of IVF was obtained by Chang (Chang MC, Fertilization of rabbit ova in vitro. Nature, 1959 8:184 (suul 7) 466) who was the first to achieve births in a mammal (a rabbit) by IVF. The newly-ovulated eggs were fertilized, in vitro by incubation with capacitated sperm in a small Carrel flask for 4 hours, thus opening the way to assisted procreation.
In 1965, Robert Edwards together with Georgeanna and Howard Jones at Johns Hopkins Hospital in the USA attempted to fertilize human oocytes in vitro (Edwards RG, Donahue RP, Baramki TA, Jones HW Jr. Preliminary attempts to fertilize human oocytes matured in vitro. Am J Obstet Gynecol. 1966; 15;96:192-200).
The first IVF pregnancy was reported by the Monash research team of Professors Carl Wood and John Leeton in Melbourne, Australia. Unfortunately, this resulted in early miscarriage (dDe Kretzer D, Dennis P, Hudson B, Leeton J, Lopata A, Outch K, Talbot J, Wood C. Transfer of a human zygote. Lancet, 1973 29;2:728-9).
Y. Menezo developed the world's first B2 culture medium, known as ‘the French medium’. This specific medium reflected the follicular, tubal and uterine environments of the sheep, rabbits and humans.
Steptoe and Edwards published a report on an ectopic pregnancy following transfer of a human embryo at the late morulae /early blastocyst stage. (Steptoe PC, Edwards RG. Reimplantation of a human embryo with subsequent tubal pregnancy. Lancet, 1976; 24:1:880-2).
The first ever IVF birth occurred in Oldham, England on July 25, 1978. This birth was the result of the collaborative work of Patrick Steptoe and Robert Edwards (Steptoe PC, Edwards RG. Birth after the reimplantation of a human embryo. Lancet, 1978 ; 12;2:366).
Lopata in Melboure described the first cycles stimulated with clomiphene citrate (Lopata A, Johnston IW, Hoult IJ, Speirs AI. Pregnancy following intrauterine implantation of an embryo obtained by in vitro fertilization of a preovulatory egg. Fertil Steril. 1980 ;33:117-20).
The introduction of culture medium (Mohr LR, Trounson AO. The use of fluorescein diacetate to assess embryo viability in the mouse. J Reprod Fertil 1980;58:189-96).
Howard and Georgianna Seegar Jones announced the delivery of the first IVF baby in the United States. This first IVF birth in the USA was achieved with the use of hMG.
Wood and his colleague introduced a foot-controlled fixed aspiration pressure control (Wood C, Leeton J, Talbot JM, Trounson AO. Technique for collecting mature human oocytes for in vitro fertilization. Br J Obstet Gynaecol. 1981;88(7):756-60).
Introduction of Clomiphene Citrate and hMG in the IVF treatment protocol (Trounson AO, Leeton JF, Wood C, Webb J, Wood J. Pregnancies in humans by fertilization in vitro and embryo transfer in the controlled ovulatory cycle. Science 1981 8;212:681-2) .
The Clamart group in France developed an LH assay (LH-SIR0 which could detect the initial LH rise in plasma allowing accurate prediction of the ideal time for the retrieval of oocytes (Testart J, Frydman R, Feinstein MC, Thebault A, Roger M, Scholler R. Interpretation of plasma luteinizing hormone assay for the collection of mature oocytes from women: definition of a luteinizing hormone surge-initiating rise. Fertil Steril. 1981 Jul;36(1):50-4).
The first French IVF birth occurred in Clamart, France by the group of Frydman and Testart.
The first IVF birth in Sweden (Hamberger L, Wikland M, Nilsson L, Janson PO, Sjo¨ gren A and Hillensjo¨ T (1982) Methods for aspiration of human oocytes by various techniques. Acta Med Rom 20,370 – 378).
Birth of first Austrian "Test tube baby" (Twin pregnancy) (Feichtinger W, Szalay S, Kemeter P, Beck A, Janisch H.Twin pregnancy after laparoscopic oocyte recovery, in-vitro fertilization and embryotransfer (author's transl)]Geburtshilfe Frauenheilkd. 1982;42(3):197-9).
The first demonstration that GnRH agonists can be used to eliminate premature luteinization and control ovarian stimulation
(Fleming R, Adam AH, Barlow DH, Black WP, MacNaughton MC, Coutts JR. A new systematic treatment for infertile women with abnormal hormone profiles. Br J Obstet Gynaecol. 1982 ;89:80-3).
The first report of the need for a delay between oocyte collection and insemination to allow oocytes collected to complete maturation (Trounson AO, Mohr LR, Wood C, Leeton JF. Effect of delayed insemination on in-vitro fertilization, culture and transfer of human embryos. J Reprod Fertil 1982;64:285-94).
Susan Lenz and Jurgen G Lauritsen demonstrated trans abdominal transvesical oocyte aspiration using an ultrasound-guided needle (Lenz S, Lauritsen JG. Ultrasonically guided percutaneous aspiration of human follicles under local anesthesia: a new method of collecting oocytes for in vitro fertilization. Fertil Steril 1982;38:673-7).
Bourn Hall worlds first IVF Conference
Maturation and fertilization of morphologically immature human oocytes in an IVF (Veeck LL, Wortham JW Jr, Witmyer J, Sandow BA, Acosta AA, Garcia JE, Jones GS, Jones HW Jr. Maturation and fertilization of morphologically immature human oocytes in a program of in vitro fertilization. Fertil Steril 1983;39:594-602).
The first paper predicting follicular steroids as a prognosticator for successful IVF (Fishel SB, Edwards RG, Walters DE. Follicular steroids as a prognosticator of successful fertilization of human oocytes in vitro. J Endocrinol. 1983;99(2):335-44.)
The Government of Victoria established a review of IVF research and practice which led to the proclamation of the Infertility (Medical Procedures) Act 1984, the first legislation to regulate IVF and its associated human embryo research.
First surrogacy embryo transfer baby born in California
First report on pregnancy following translaparoscopic GIFT procedure (Asch RH, Ellsworth LR, Balmaceda JP, Wong PC. Pregnancy after translaparoscopic gamete intrafallopian transfer. Lancet, 1984;3;2:1034-5).
The first report on pregnancy following IVF and egg donation in a woman with primary ovarian failure. (Lutjen P, Trounson A, Leeton J, Findlay J, Wood C and Renou P. The establishment and maintenance of pregnancy using in vitro fertilization and embryo donation in a patient with primary ovarian failure. Nature, 1984;307,174 – 175).
Introduction of GnRH agonists to the IVF treatment protocol (Porter RN, Smith W, Craft IL, Abdulwahid NA, Jacobs HS. Induction of ovulation for in-vitro fertilisation using buserelin and gonadotropins. Lancet, 1984;1;2:1284-5).
A report of pregnancy following transfer of intact frozen-thawed embryos (Zeilmaker GH, Alberda AT, van Gent I, Rijkmans CM, Drogendijk AC.Two pregnancies following transfer of intact frozen-thawed embryos. Fertil Steril. 1984;42(2):293-6).
An unusual report of the possibility that abnormal spermatozoa could be enriched and give rise to healthy babies. (Cohen J, Fehilly CB, Fishel SB, Edwards RG, Hewitt J, Rowland GF, Steptoe PC, Webster J. Male infertility successfully treated by in-vitro fertilisation.Lancet. 1984, 2;1(8388):1239-40).
The first publication demonstrating HCG secretion by the human embryo (Fishel SB, Edwards RG, Evans CJ. Human chorionic gonadotropin secreted by preimplantation embryos cultured in vitro.Science. 1984, 24;223(4638):816-8).
The world's first IVF quadruplets were born on January 6, 1984, in Melbourne.
Human pregnancy by in vitro fertilization (IVF) using sperm aspirated from the epididymis. (Temple-Smith PD, Southwick GJ, Yates CA, Trounson AO, de Kretser DM. Human pregnancy by in vitro fertilization (IVF) using sperm aspirated from the epididymis. J In Vitro Fert Embryo Transf. 1985;2(3):119-22).
First description of transvaginal sector scan sonography for needle-guided transvaginal follicle aspiration (Feichtinger W, Kemeter P. Transvaginal sector scan sonography for needle guided transvaginal follicle aspiration and other applications in gynecologic routine and research. Fertil Steril 1986 May;45(5):722-5).
The first preclinical evaluation of pronuclear formation by microinjection of human spermatozoa into human oocytes. (Lanzendorf SE, Maloney MK, Veeck LL, Slusser J, Hodgen GD, Rosenwaks Z. A preclinical evaluation of pronuclear formation by microinjection of human spermatozoa into human oocytes. Fertil Steril. 1988 May;49(5):835-42).
1989First report on biopsy of human preimplantation embryos and sexing by DNA amplification. (Handyside AH, Pattinson JK, Penketh RJ, Delhanty JD, Winston RM, Tuddenham EG. Biopsy of human preimplantation embryos and sexing by DNA amplification. Lancet. 1989;18;1:347-9).
Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification. (Handyside AH, Kontogianni EH, Hardy K, Winston RM. Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification. Nature. 1990;19;344:768-70).
Fishel et all reported about twin birth after subzonal insemination (Fishel S, Antinori S, Jackson P, Johnson J, Lisi F, Chiariello F, Versaci C. Twin birth after subzonal insemination. Lancet. 1990 24;335(8691):722-3).
Pregnancy after embryo biopsy and coamplification of DNA from X and Y chromosomes. (Grifo JA, Tang YX, Cohen J, Gilbert F, Sanyal MK, Rosenwaks Z. Pregnancy after embryo biopsy and coamplification of DNA from X and Y chromosomes. JAMA 1992, 12;268(6):727-9).
Ovulation induction by endogenous LH released by the administration of an LHRH agonist after follicular stimulation for in vitro fertilization (Emperaire JC, Ruffié A, Audebert AJ. Ovulation induction by endogenous LH released by the administration of an LHRH agonist after follicular stimulation for in vitro fertilization. J Gynecol Obstet Biol Reprod (Paris). 1992;21:489-94. French).
First report on cumulative conception and live birth rates after IVF in relation to patient's age and cause of infertility (Tan SL, Royston P, Campbell S, Jacobs HS, Betts J, Mason B, Edwards RG. Cumulative conception and livebirth rates after in-vitro fertilisation. Lancet. 1992,6;339(8806):1390-4).
First two births from replacement of frozen embryos produced with epididymal sperm (Patrizio P, Silber S, Ord T, Marello E, Balmaceda JP, Asch RH. Replacement of frozen embryos generated from epididymal spermatozoa: the first two pregnancies. Hum Reprod 1992;7(5):652-3)
Report on using Erbium YAG laser for micromanipulation of oocytes and spermatozoa (Feichtinger W, Strohmer H, Radner KM. Erbium YAG laser for micromanipulation of oocytes and spermatozoa. Lancet. 1992, 11;340(8811):115-6).
Investigating the role of FSH in hypogonadotropic women usung the new recombinant FSH drug (Schoot DC, Coelingh Bennink HJ, Mannaerts BM, Lamberts SW, Bouchard P, Fauser BC. Human recombinant follicle-stimulating hormone induces growth of preovulatory follicles without concomitant increase in androgen and estrogen biosynthesis in a woman with isolated gonadotropin deficiency. J Clin Endocrinol Metab 1992; 74: 1471-3).
The second term pregnancy after ICSI reported by a group in Sweden (Hamberger et al, 1993, In Gordts S (ed) Proceedings of European Symposium on Micromanipulation. Drukkerij Nauwelaerts, Leuven, Belgium, pp 85).
Confirmation that men with congenital absence of the vas defference, have cystic fibrosis mutations which can be transmitted to the offspring (Patrizio P, Asch RH, Handelin B, Silber SJ. Aetiology of congenital absence of vas deferens: genetic study of three generations. Hum Reprod. 1993;8(2):215-20).
First report on the use of TESE (testicular sperm extraction) and ICSI (Silber SJ, Nagy ZP, Liu J, Godoy H, Devroey P, Van Steirteghem AC. Conventional in-vitro fertilization versus intracytoplasmic sperm injection for patients requiring microsurgical sperm aspiration. Hum Reprod. 1994;9(9):1705-9).
First Preganancy and birth following treatment with Rec-FSH (Devroey P, Mannaerts B, Smith J, Coelingh Bennink H, Van Steirteghem A. First established pregnancy and birth after ovarian stimulation with recombinant human follicle stimulating hormone (Org 32489). Hum Reprod.1993 Jun;8(6):863-5).
The first live birth as a result of IVM following transvaginal ultrasound–guided oocyte collection. (Trounson A, Wood C, Kausche A. In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients. Fertil Steril 1994;62(2):353-62).
Birth after blastocyst development from IVM oocyte plus ICSI plus Assisted Hatching (Barnes FL, Crombie A, Gardner DK, Kausche A, Lacham-Kaplan O, Suikkari AM, Tiglias J, Wood C, Trounson AO. Blastocyst development and birth after in-vitro maturation of human primary oocytes, intracytoplasmic sperm injection and assisted hatching. Hum Reprod. 1995;10(12):3243-7).
The first report of aneuploidy testing (Munné S, Sultan KM, Weier HU, Grifo JA, Cohen J, Rosenwaks Z. Assessment of numeric abnormalities of X, Y, 18, and 16 chromosomes in preimplantation human embryos before transfer. Am J Obstet Gynecol. 1995;172(4 Pt 1):1191-9; discussion 1199-201 ).
Zenzes from the group of Casper in Toronto demonstrated adverse effects of cigarette smoking on nuclear spindle. (Zenzes MT, Wang P, Casper RF. Cigarette smoking may affect meiotic maturation of human oocytes. Hum Reprod. 1995;10(12):3213-17).
The first report in which spermatids were used to achieve pregnancy. (Fishel S, Green S, Bishop M, Thornton S, Hunter A, Fleming S, al-Hassan S. Pregnancy after intracytoplasmic injection of spermatid. Lancet. 1995, 24;345(8965):1641-2).
Dmitri Dozortsev and coworkers have discovered that oocyte activation during ICSI is triggered by a water-soluble, heat-sensitive, non species specific cytosolic sperm factor. (Dozortsev D, Rybouchkin A, De Sutter P, Qian C, Dhont M. Human oocyte activation following intracytoplasmic injection: the role of the sperm cell. Hum Reprod. 1995;10(2):403-7).
The larget study done in the filed of IVF comparing urinary FSH with Rec-FSH (Out, H.J., Mannaerts, B.M., Driessen, S.G. and Coelingh Bennink, H.J. A prospective, randomized, assessor blind, multicenter study comparing recombinant and urinary follicle-stimulating hormone in in vitro fertilization. Hum. Reprod., 1995: 10, 2534 –2540).
The Valencia group reported on the first pregnancy employing cryopreserved testicular sperm following IVF-ICSI. . (Gil-Salom M, Romero J, Minguez Y, Rubio C, De los Santos MJ, Remohí J, Pellicer A. Pregnancies after intracytoplasmic sperm injection with cryopreserved testicular spermatozoa. Hum Reprod. 1996;11(6):1309-13).
Discovery that some men with severe oligoasthenospermia have deletions in the Y-chromosome (Reijo R, Alagappan RK, Patrizio P, Page DC. Severe oligozoospermia resulting from deletions of azoospermia factor gene on Y chromosome. Lancet, 1996, 11;347(9011):1290-3).
Jurisicova from the Casper group was the first to recognize that preimplantation of human embryo fragmentation involved programmed cell death. (Jurisicova A, Varmuza S, Casper RF. Programmed cell death and human embryo fragmentation. Mol Hum Reprod. 1996;2(2):93-8).
Casper and his colleagues were the first to demonstrate and introduce the use of the hypo-osmotic swelling test for selection of immotile sperm for ICSI. (Casper et al. 1996 Fertil Steril 65:972)
First report on cytoplasmic transfer (Cohen J, Scott R, Schimmel T, Levron J, Willadsen S. Birth of infant after transfer of anucleate donor oocyte cytoplasm into recipient eggs. Lancet, 1997, 19;350(9072):186-7)
Sun, Jurisicova and Casper described the use of TUNEL for detection of DNA fragmentation in sperm and correlation with IVF outcome. They showed almost uniform presence of DNA fragmentation in round spermatids as the explanation for failure to achieve pregnancy with these immature gametes. (Sun JG, Jurisicova A, Caspe RF. Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro. Biol Reprod. 1997 Mar;56(3):602-7).
First births of babies from frozen oocytes following use of ICSI: - Porcu et al, Birth of a healthy female after intracytoplasmic sperm injection of cryopreserved human oocytes. (Porcu E, Fabbri R, Seracchioli R, Ciotti PM, Magrini O, Flamigni C. Birth of a healthy female after intracytoplasmic sperm injection of cryopreserved human oocytes. Fertil Steril. 1997;68(4):724-6).
First report on cytoplasmic transfer (Cohen J, Scott R, Schimmel T, Levron J, Willadsen S. Birth of infant after transfer of anucleate donor oocyte cytoplasm into recipient eggs. Lancet, 1997;19;350:186-7).
Falloposcopic GIFT: Births after transcervical gamete intrafallopian transfer with a falloposcopic delivery system. (Porcu E, Dal Prato L, Seracchioli R, Petracchi S, Fabbri R, Flamigni C. Births after transcervical gamete intrafallopian transfer with a falloposcopic delivery system. Fertil Steril. 1997 Jun;67(6):1175-7).
Pregnancy after treatment with three recombinant gonadotropins (Agrawal R, West C, Conway GS, Page ML, Jacobs HS. Pregnancy after treatment with three recombinant gonadotropins. Lancet. 1997;4;349:29-30).
First establish pregnancy using recombinant FSH and GnRH antagonist (Itskovitz-Eldor J, Kol S, Mannaerts B, Coelingh Bennink H. First established pregnancy after controlled ovarian hyperstimulation with recombinant follicle stimulating hormone and the gonadotrophin-releasing hormone antagonist ganirelix (Org 37462). Hum Reprod. 1998;13:294-5).
Gardner introduced sequential media and blastocyst transfer which is now greatly assists in the move to single embryo transfer (Gardner DK, Schoolcraft WB, Wagley L, Schlenker T, Stevens J, Hesla J. A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization. Hum Reprod 1998;13:3434-40).
Births after intracytoplasmic injection of sperm obtained by testicular extraction from men with nonmosaic Klinefelter's syndrome (Palermo GD, Schlegel PN, Sills ES, Veeck LL, Zaninovic N, Menendez S, Rosenwaks Z. Births after intracytoplasmic injection of sperm obtained by testicular extraction from men with nonmosaic Klinefelter's syndrome. N Engl J Med. 1998, 26;338(9):588-90).
The first pregnancies following embryo culture in sequential media and transfer at the blastocyst stage of development (Jones GM, Trounson AO, Gardner DK, Kausche A, Lolatgis N, Wood C. Evolution of a culture protocol for successful blastocyst development and pregnancy. Hum Reprod. 1998 ;13:169-77).
First ovum pick-up under 3-D ultrasound vision (Feichtinger W. Follicle aspiration with interactive three-dimensional digital imaging (Voluson): a step toward real-time puncturing under three-dimensional ultrasound control. Fertil Steril. 1998;70(2):374-7).
In 1998 first reports on births from frozen GV eggs, and donor eggs: - Tucker et al. Birth after cryopreservation of immature oocytes with subsequent in vitro maturation. (Tucker MJ, Wright G, Morton PC, Massey JB. Birth after cryopreservation of immature oocytes with subsequent in vitro maturation. Fertil Steril. 1998;70(3):578-9); Tucker et al. Clinical application of human egg cryopreservation. (Tucker MJ, Morton PC, Wright G, Sweitzer CL, Massey JB. Clinical application of human egg cryopreservation. Hum Reprod. 1998;13(11):3156-9).
Cryopreserved oocytes and testicular sperm: first ever birth. (Porcu E, Fabbri R, Petracchi S, Ciotti PM, Flamigni C. Ongoing pregnancy after intracytoplasmic injection of testicular spermatozoa into cryopreserved human oocytes. Am J Obstet Gynecol. 1999;180:1044-5).
Cryopreserved oocytes and epididimal sperm: first ever birth. (Porcu E, Fabbri R, Ciotti PM, Petracchi S, Seracchioli R, Flamigni C. Ongoing pregnancy after intracytoplasmic sperm injection of epididymal spermatozoa into cryopreserved human oocytes. J Assist Reprod Genet. 1999;16(5):283-5).
Oktay and Karlikaya were the first to report on ovarian tissue transplants after frozen storage. (Oktay K, Karlikaya G. Ovarian function after transplantation of frozen, banked autologous ovarian tissue. N Engl J Med. 2000 Jun 22;342(25):1919).
The development of a completely chemically defined protein-free embryo culture medium and the births of the first batch of babies generated from the fertilization of eggs collected and inseminated in the said protein-free medium using spermatozoa also prepared in the same protein-free medium in both conventional IVF and ICSI. (Ali, Shahata MAM., Al-Natsha SD. Formulation of a protein-free medium for human assisted reproduction. Hum. Reprod. 2000 15: 145-156).
Cryopreserved oocytes and frozen sperm: first ever birth. (Porcu E, Fabbri R, Damiano G, Giunchi S, Fratto R, Ciotti PM, Venturoli S, Flamigni C. Clinical experience and applications of oocyte cryopreservation. Mol Cell Endocrinol. 2000:27;169(1-2):33-7).
Birth of an infant from cryopreserved embryos (zygotes) produced by IVM oocytes derived from an unstimulated patient with PCOS (Chian RC, Gülekli B, Buckett WM, Tan SL. Pregnancy and delivery after cryopreservation of zygotes produced by in-vitro matured oocytes retrieved from a woman with polycystic ovarian syndrome. Hum Reprod. 2001;16(8):1700-2).
First report on oocyte cryopreservation to save fertility in cancer patients. (Porcu E, Fabbri R, Damiano G, Fratto R, Giunchi S, Venturoli S. Oocyte cryopreservation in oncological patients. Eur J Obstet Gynecol Reprod Biol. 2004;113 Suppl 1:S14-6).
The first reported live born following preimplantation genetic diagnosis for Retinoblastoma (Xu K, Rosenwaks Z, Beaverson K, Cholst I, Veeck L, Abramson DH. Preimplantation genetic diagnosis for retinoblastoma: the first reported liveborn. Am J Ophthalmol. 2004;137(1):18-23).
A novel multi-gradient freezing technique for the cryopreswervation of the whole ovary. Thawing the ovary resulted in normal ovarian architecture and no damage to the vascular wall or intima. (Arav and Pasquale 2007 Yale Practice 12:2)
First IVM egg donation pregnancy in North America achieved by McGill Reproductive Centre (Holzer H, Scharf E, Chian RC, Demirtas E, Buckett W, Tan SL. In vitro maturation of oocytes collected from unstimulated ovaries for oocyte donation. Fertil Steril. 2007;88(1):62-7).2008
The first report of DNA fingerprinting to identify the blastocyst of origin for live-births and that gene expression profiles of biopsied trophectoderm can discriminate between viable and non-viable blastocysts. (Gayle M. Jones, David S. Cram, Bi Song, Georgia Kokkali, Kostas Pantos, and Alan O. Trounson. Novel strategy with potential to identify developmentally competent IVF blastocysts. Hum. Reprod. 2008; 23: 1748-1759).
Cryopreserved oocytes in cancer patients: first ever birth of healthy twins after oocyte cryopreservation and bilateral ovariectomy. (Porcu E, Venturoli S, Damiano G, Ciotti PM, Notarangelo L, Paradisi R, Moscarini M, Ambrosini G. Healthy twins delivered after oocyte cryopreservation and bilateral ovariectomy for ovarian cancer. Reprod Biomed Online. 2008;17:265-7).
Simon Fishel and his group from CARE Fertility, Nottingham, reported about a Live birth after polar body array comparative genomic hybridization. (Fishel S, Gordon A, Lynch C, Dowell K, Ndukwe G, Kelada E, Thornton S, Jenner L, Cater E, Brown A, Garcia-Bernardo J. Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF? Fertil Steril. 2010;93(3):1006.e7-1006.e10).
Prof. Laufer at the Hadassah Medical Center in Jerusalem reported on a viable pregnancy achieved in a woman who carries the defective BRCA2 genes after In-Vitro Fertilized Embryos were tested and implanted. (Sagi M, Weinberg N, Eilat A, Aizenman E, Werner M, Girsh E, Siminovsky Y, Abeliovich D, Peretz T, Simon A, Laufer N. Preimplantation genetic diagnosis for BRCA1/2--a novel clinical experience. Prenat Diagn. 2009;29(5):508-13).


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SweetEscape is an on demand photography platform that can capture any moment, any time and any where you would like. The holidays are just around the corner, and it's about that time for you to decide on your vacation plans (if you have any). Perhaps you've been saving up for an extremely fancy destination, but realistically... a glam holiday like the Hilton sisters would have it or any of those A-list Hollywood stars are probably not ideal for your situation or lifestyle, and that's A-okay! You can still go to your luxurious dream destination, however, with a few minor twists. If you're wondering how you could possibly travel somewhere expensive without running out of (too much) money, we've come up with 5 great tips below for you to lower your spendings and make it a not-so-expensive vacation. Read on for these tips!
Exploring new places and parts of the world comes in a package with experimenting culinary delights that those places have to offer. You might be interested in eating all fancy in a 5-star hotel within the area, or perhaps you were recommended by various (loaded) people to try out great dishes in some of the most expensive restaurants around your vacation town. The matter of fact is that it's not a necessity to be eating in all of the fancy places for a complete vacation feel. Most often than not, the fancier places don't really offer you food that is authentic to the culture of your holiday destination. Fancy restaurants popularly offer a range of international delicacies... in which wouldn't fulfill your culinary experience authentically.
Many would say that one of the best parts of going on a vacation is the actual stay in the hotel or whichever choice of accommodation you choose. We agree to that most definitely, because there's certainly a pleasant feeling that arises from those far-away hotel stays. Perhaps your parents took you traveling a lot when you were younger, and you just new that the moment you get on that plan, it's bye-bye to your real home for a while and hello to an entirely new place and temporary home. Could it be the nostalgic feeling behind it? It could certainly be. But it could also be related to the whole atmosphere and vibe that screams "HOLIDAY".
We know that there are convenience and drugstores just about anywhere. Toothbrushes, deodorant, shampoo, soap, everything and anything you need are provided at the store. You might not realize that buying all these will actually add up to your spendings, and why buy when you can bring them from home? Got a spare toothbrush, toothpaste and all that back home? Bring 'em! You can even make them travel sized if you can't be bothered by bringing all of that along with you. You'll certainly be saving money that way, and really, it's the little things that matter (like bringing your own toiletries).
One of the hardest things to avoid during the holiday travels is hands down the desire to hit the shops for some shoppin'. How can you not? The entire vibe makes you feel that way, and for some reason you just can't help but be drawn to the shops to your left and right. How could you miss out on those fancy Italian boutiques or perhaps the shops all through Rodeo Drive, right? We know, vacations seem incomplete without the act of shopping. But really, you'll be saving more money for the better things, such as trying out the different foods, sightseeing and exploring various attractions. So, if you can't resist, avoid the shop til you drop trend and be wise about your spendings during your vacay!
If you're traveling internationally, you'll most likely bring some cash with you for convenient transactions. If you stay in a place with a safe lock, then we suggest you stash your cash in there and only bring a certain amount with you. Why? So that you don't overspend! It's so much easier to overspend when... you've got something to spend. Say that you have 1000 USD with you, divide it to say 100 USD per day, and leave the rest in your safe box or suitcase (don't forget to lock it up). This way, you'll be controlling your spendings and of course, spending only what you have. You'll be limited, but that's the whole point! The limitations will save you a huge deal for your vacation to be more budget-friendly compared to you just bringing your entire savings in your bag every day.
Planning on a friendly-on-the-wallet trip to somewhere expensive and fancy? Don't forget to book a session with SweetEscape for great photos to capture those beautiful moments for you. With SweetEscape, we guarantee you will have a great time with our photographers. We're here #ForEvery moment, so book your session today and let's #makelifememorable!

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The jingling sound of money entering Judy Hancock's campaign chest has been the main noise emerging in the relatively quiet Democratic primary for the 3rd Congressional District nomination.
The race features Hancock, an international trade attorney, and Preston L. Conner, founder of the National Association of Part-time and Temporary Employees.
The winner will face the Republican victor in the six-way GOP primary for the seat being vacated by U.S. Rep. Jan Meyers, who is retiring.
The 3rd District includes most of Douglas County and all of Johnson, Wyandotte and Miami counties.
Hancock is expected by most observers to have the advantage for the Democratic nomination. She received 43.4 percent of the vote in 1994 when she challenged Mrs. Meyers.
Since deciding to run last winter, Hancock has been amassing a large campaign fund that totals more than $300,000. Her campaign staff said Hancock has done little spending in her race, keeping most of her money for the general election.
But to get the nomination, she faces political newcomer Conner in the Aug. 6 primary.
Conner, 38, as president of the National Association of Part-Time and Temporary Employees, lobbies Congress on employment issues and economic policy.
Conner said he plans to spend less than $5,000 on his campaign.
"Money is not a guarantee to win," he said.

domain: politics


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Foraging at the river's edge.
I nearly missed this guy as blended in so well - new species for me!
In the picnic area. Also seen at Herdsman Lake
Drinking from a waterlily tank.
The Buff-banded Rail (Gallirallus philippensis) is a distinctively coloured, highly dispersive, medium-sized rail of the family Rallidae. This species comprises several subspecies found throughout much of Australasia and the south-west Pacific region, including the Philippines (where it is known as Tikling), New Guinea, Australia, New Zealand (where it is known as the Banded Rail or Moho-pereru in Māori), and numerous smaller islands, covering a range of latitudes from the tropics to the Subantarctic.

domain: geography


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Comprehending the Different Types of Romantic relationships
Published on 02 Sep '21
People are between many different types of relationships, which fluctuate greatly in their nature. Depending https://toprussianbrides.com/macedonian-brides/ on your own social environment, there may be various kinds of relationships based on a purposes. These kinds of relationships differ in their level of closeness or perhaps distance, and can be a necessary part of your social support program. These interactions are important designed for both your physical and mental health. Discussing look at the different types of relationships, and what every one has to supply.
The usual types of relationships happen to be friendships, home relationships, romantic romantic relationships, and platonic relationships. You can also find several subtypes within each category. Platonic relationships entail friends, coworkers, and other conditions, but tend not to require any kind of romantic fascination or choice. As opposed to romantic interactions, platonic romantic relationships require almost no commitment with your part. Inevitably, the choice is yours to make. The type of relationship you choose depends on how deeply you bond with your spouse.
A sexual romantic relationship lacks mental depth. Should you and your spouse do not be happy with each other, it is time to look for a much more serious romantic relationship. You might want to seek out help by a certified romantic relationship coach. Romance Hero may help you overcome complicated situations inside your relationship and start with the love and keenness you need. They will also assist you to improve your general relationship well-being. These romantic relationships will be the finest ones suitable for you! If you’re buying a relationship mentor in Denver, I suggest you take a look at my site.
The first step towards understanding your partner should be to understand yourself. By doing so, you can keep your vibration substantial and be aware about what will advantage both of you the most. Once you find the perfect partner, others will get caught in place. However , to maintain a great relationship, you ought to have other types of relationships too. And this is usually where understanding your partner can really be handy. You may have to learn regarding the different person’s personal qualities to raised understand the other person.
When a romantic relationship turns into unhappy, it has the time for you to evaluate the situation. Why is a romantic relationship happy? Are generally there certain things you should look for in your partner? If you feel comfortable with yourself plus your partner, you’re in a healthy and balanced relationship. Usually, the relationship is trouble. In such a situation, you might like to consider moving forward to a new place. For anyone who is unhappy with your relationship, it’s best to work on a fix before it might be too late.
Relationships can be considered casual or devoted. In a everyday relationship, two people get along very well but is not going to talk about a deep emotional interconnection. While they may not be as incorporated into each other peoples lives as with a devoted relationship, they are often more likely to become existence partners. Usually, people in casual romantic relationships don’t relate to each other since “boyfriend” or “girlfriend” or maybe even “partner” the moment describing all of them.

domain: psychology


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Rugged Material: Made of high quality Nylon webbing,and stainless steel zinc alloy buckle which can withstand 200-250kg pull force.
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domain: pet


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Ganni’s music-filled autumn/winter 2021 extravaganza provided light relief from lockdown woes, complete with a stellar cast of emerging artists who brought the show to life. Building upon its existing selection of cult products – endorsed by every influencer under the sun – the Danish brand’s latest offering saw its famous frilled collars streamlined and elongated; and the arrival of a new trouser silhouette distinguished by balloon legs and a “bubble-ish waist”.
Alongside the fresh takes on existing Ganni design flairs, its universally-popular footwear remained chunky as ever (it seems like we’re set to stomp into next season the same way we stomped out of the last). Neon-green tractor-sole Chelseas – both tall and mid-length – whipstitch cowboy boots and patterned trainers all featured, but one shape trumped the lot: the lug-sole loafer.
A hybrid of Ganni’s best-selling elevated loafer and shell brogue, the new style is bound to be a hit with preppy dresser and loafer enthusiast Bella Hadid, who recently swapped out her trusty Montelpare Tradition penny loafers for Ganni’s tall boots during a trip to Paris
“We have given the classic Ganni loafers a new boyish twist with a super chunky rubber sole that makes you walk a little taller,” creative director Ditte Reffstrup tells British Vogue. “I am not great at wearing heels, but when the world reopens I am looking forward to wearing these chocolate patent loafers with suits and dresses for both daytime and going out looks.”
Available in a hat trick of shades – black, check and chocolate-brown patent – the brand’s new shoe will no doubt tempt its staunchly loyal Scandi followers to expand their loafer collections. Many influential dressers have favoured platform styles from Prada and Louis Vuitton of late, but come autumn, a fresh loafer could be edging its way into the limelight.
More from British Vogue:

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|Title:||Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines||Authors:||St John, A.L.
|Issue Date:||Nov-2009||Citation:||St John, A.L., Abraham, S.N. (2009-11). Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines. Nature Medicine 15 (11) : 1259-1265. ScholarBank@NUS Repository. https://doi.org/10.1038/nm.2036||Abstract:||We report that infection of draining lymph nodes (DLNs) by Salmonella typhimurium results in the specific downregulation of the homeostatic chemokines CCL21 and CXCL13, which are essential for normal DLN organization and function. Our data reveal that the mechanism of this suppression is dependent on S. typhimurium LPS (sLPS). The decrease in CCL21 expression involves interaction between sLPS and CCL21-producing cells within DLNs, triggering a distinct Toll-like receptor 4 (TLR4)-mediated host signaling response. In this response, suppressor of cytokine signaling-3 (Socs3) is upregulated, which negatively regulates mothers against decapentaplegic homolog-3 (Smad3)-initiated production of CCL21. Disruption of lymph node architecture and cellular trafficking enhances S. typhimurium virulence and could represent a mechanism of immune suppression used by pathogens that primarily target lymphoid tissue. © 2009 Nature America, Inc. All rights reserved.||Source Title:||Nature Medicine||URI:||http://scholarbank.nus.edu.sg/handle/10635/130016||ISSN:||10788956||DOI:||10.1038/nm.2036|
|Appears in Collections:||Staff Publications|
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What are the postcodes of the district Slotermeer-Zuidwest? On this page you will find postcode information about the district Slotermeer-Zuidwest in Amsterdam. There are 6 neighbourhoods in the district Slotermeer-Zuidwest.
These are all postcode numbers of Slotermeer-Zuidwest, see per postcode number the underlying postcodes. In total Slotermeer-Zuidwest 2 has postcode numbers.
These are all neighbourhoods in the district Slotermeer-Zuidwest, see the corresponding postcodes and streets for each neighbourhood. Slotermeer-Zuidwest has a total of 6 neighbourhoods.
The overview of postcodes and streets in the district Slotermeer-Zuidwest
Some postcodes of the district Slotermeer-Zuidwest. How many postcodes Slotermeer-Zuidwest has? Slotermeer-Zuidwest has 398 postcodes. Via the 4-digit postcode number you can find every postcode of the district Slotermeer-Zuidwest.
How many streets does Slotermeer-Zuidwest have? Slotermeer-Zuidwest has 139 streets. Below are a number of streets of the district Slotermeer-Zuidwest.
Slotermeer-Zuidwest is a district in the place Amsterdam within the municipality Amsterdam of the province Noord-Holland. The district Slotermeer-Zuidwest has 398 postcodes with 139 streets and the district is divided into 6 neighbourhood(s)
Slotermeer-Zuidwest counts 8 460 households with 17 260 inhabitants. The households are consists out of 52% single households, 31% households with children and 17% households without children. Of the inhabitants in Slotermeer-Zuidwest, 5 005 are married, that is 29% of the inhabitants of Slotermeer-Zuidwest.
The overview of stations and supermarkets in Slotermeer-Zuidwest and surroundings.
These 5 stations with postcode and address can be found near Slotermeer-Zuidwest.
|Station Amsterdam Lelylaan||Cornelis Lelylaan 35||1062HD||2.55 km|
|Station Amsterdam Sloterdijk||Orlyplein 105||1043DT||2.71 km|
|Station Zaandam||Provincialeweg 25||1506MA||7.08 km|
|Station Amsterdam Zuid WTC||Zuidplein 10||1077XV||7.31 km|
|Station Halfweg-Zwanenburg||Haarlemmerstraatweg 29||1165MJ||8.22 km|
These are the 5 supermarkets closest to the district Slotermeer-Zuidwest.
|Dekamarkt||Slotermeerlaan 67||1064HA||0.25 km|
|Aldi||Plein '40-'45 12||1063KR||0.81 km|
|Albert Heijn||Willem Kraanstraat 2||1063MG||0.87 km|
|Albert Heijn||Lambertus Zijlplein 8||1067JS||1.87 km|
|Vomar||Lambertus Zijlplein 119||1067JR||1.93 km|

domain: sociology


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The Ministry of Community Safety and Correctional Services is investigating a fire and hunger strike at Sudbury District Jail.
While few details were released, a spokesperson confirmed that a fire was lit in the jail Monday, and that six inmates refused to eat their dinner on Tuesday.
“There was an incident at the Sudbury Jail on Monday and the ministry is currently investigating that,” Greg Flood, a ministry spokesperson, said. “It’s my understanding that six inmates did not accept the dinner provided, but have accepted breakfasts and lunch (on Wednesday).
“The ministry continues to monitor the situation.”
Flood was unable to comment further on the cause of the fire or the hunger strike.
“I can’t get into specifics. Obviously, the investigation is ongoing,” he said, adding that the ministry has to be aware of security issues.
A friend of an inmate at the jail, who did not want her name used, said the incident started when a prison guard “antagonized” some of the inmates.
“(Inmates) started a little fire with newspapers and toilet paper,” she said, adding that the fire was started in a community area of the jail.
The friend went on to say that the inmates were moved into a different area of the jail and were unhappy with the conditions there.
“The inmates started complaining. The toilets were (clogged), they couldn’t flush them. They were soiled. (Inmates) had no running water,” she said, adding that prisoners began a riot, which led them to be stripped of everything but their boxers.
“I was told they were stripped of their clothes,” and had their mattresses taken away, she said, explaining that the hunger strike started soon after.
The friend also said the windows were left open during this time.
“They froze. I don’t care who you are. They’re still human beings,” she said.
While Flood said that the six inmates have started eating, the friend, who visited jail on Wednesday, said they have not, and refuse to do so until they get an apology for how they were treated.


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The divorce rate in the U.S. is an estimated 45 percent. Making the decision to get a divorce is never easy, and choosing the divorce attorney to handle your case can make it feel more final. On top of that, your first consultation with a divorce attorney can be stressful. However, when you’re prepared for […]
Kessler & Solomiany, LLC Blog
Atlanta high-profile divorce attorney Randy Kessler appeared on Good Day Atlanta to discuss the defamation trial between Johnny Depp and Amber Heard. Watch the segment below.
Atlanta celebrity divorce attorney Randall Kessler appeared on an HLN segment titled “Not Just the Rich: Why You Should Consider a Prenup.” In the segment, he is asked if anything is off limits within the confines of a prenup. Watch the video here:
Atlanta divorce attorney Randy Kessler was featured in a video from Tennessee’s Miles Mason Family Law Group. In the video, titled “Best Divorce Mediation Preparation Tips,” various attorneys provide their tips for preparing for and going through a divorce mediation.
Randy Kessler was a guest on the “The Future of Resolution” podcast. The episode is the third of the podcast’s second season and is titled “Randy Kessler on Family Law and Domestic Mediation.” In it, Randy discusses “complex divorce cases, custody issues, and the benefits of domestic mediation” with host the host, judge Jason Harper. […]
There is no question that lawyers are not all cut from the same cloth. Some attorneys specialize in family law, while others focus on personal injury cases. The law is complicated and includes multiple different facets. Someone who works primarily on defending accused criminals shouldn’t represent a client trying to file a medical malpractice case. […]
Alimony is one of the most contentious parts of any divorce. Some former spouses need it. Others think they’re entitled to more than they’re getting. Some people don’t mind paying, and some think it’s a revenge-based money grab from their ex. And even after the details have been worked out, something may happen, and you […]
Atlanta celebrity divorce attorney Randy Kessler appeared on Court TV to discuss the high-profile divorce between Kim Kardashian and Kanye West. Part of the challenge of going through a divorce in the public eye is how social media posts can affect the case, as discussed in the segment, which can be viewed below.
Attorney Randy Kessler appeared on Good Day Atlanta in January to discuss what couples should keep in mind about divorce in the new year.
Atlanta family law attorney Randy Kessler appeared on 11Alive earlier this month to discuss the state of divorces during the pandemic. Watch the interview here.


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A reverse cycle air-conditioning system denotes a system that can heat or cool a room from the same unit. Additionally, these systems dehumidify and filter the air. As a result, the room air becomes comfortable, clean and healthy.
It is an energy-efficient unit that ensures the room is warm during cold seasons and cool in hot weather.
How Reverse Cycle Air Conditioning Work
As we already know, the reverse air conditioning system performs two roles, heating and cooling. We shall discuss how it performs these two functions separately.
Warming Indoor Air
During cold weather, you need to raise the air temperatures within the room to keep you warm. The reverse cycle works differently from traditional heating systems that must create energy to warm indoor rooms. Instead, the system absorbs heat from the outside air to warm up the air inside.
Technically speaking, the refrigerant goes through an external coil (condenser) which absorbs heat from the outside air. The refrigerant gets pumped by the compressor towards the fan coil units (evaporator) within the home. This action releases heat, thereby warming the room.
As this happens, cold air from the room is pulled into the system. The external coil reverses its role to become an evaporator that discharges the colder air from the outside.
Cooling the Indoor Air
During hot seasons, you need to switch the system to cooling mode. The unit draws cold air from the outside and releases it to the inside of a house. The condenser and the evaporator exchange roles and act in an opposite fashion when warming the air.
Warm air in the house is also pulled into the system and dissipated outside. As a result, the indoor temperatures fall drastically to keep the home in desired heat levels.
Benefits of Reverse Cycle Systems
a. Two-in-one Solution: This kind of filtration system helps to keep your indoors warm and cool from the same unit. This feature helps to save on the cost of installing multiple systems to perform reverse roles.
b. Eco-friendly: The reverse cycle systems tend to have little greenhouse gas emissions compared to other systems such as the electric heaters. The refrigerant used today helps to lower global warming by 66% compared to conventional types.
c. Value for Money: The reverse cycle systems are energy efficient. They use heat transfer principles instead of creating energy, thus lesser energy consumption. Innovations in the systems help to make the systems use less energy. With modern systems, one kilowatt of electricity produces three or more kilowatts of heating or cooling.
d. Durability: These systems are designed to last. A good reverse cycle may last up to 20 years with proper care and maintenance.
e. Reduced Noise: The systems are quieter compared to most options. Therefore, users do not have to compromise their comfort for pleasant air.
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COVID-19 cases at UF remain steady at a seven-day positivity rate average of 1%. This comes as the university announced students, faculty and staff could pre-register for the COVID-19 vaccine.
Since March 22, 12 UF employees and 176 students have tested positive for the virus at on-campus locations. The week before, nine employees and 109 students tested positive.
As of Monday, the university has documented 9,473 total positive tests since it began keeping track March 18, 2020. This month, 498 people have tested positive.
The seven-day average for positive results has remained at 1% since March 12. The most tests performed on campus in one day in the last week came March 24 with 2,225 results. Of those tests, 2,199 were negative and 26 were positive. March 25 and March 29 had the most positive tests in one day with 32 each.
A campuswide email sent Tuesday afternoon announced vaccine registration opened to UF affiliates through One.UF. Students, faculty and staff are able to pre-register for appointments that start April 5 at Ben Hill Griffin Stadium. This is concurrent with Gov. Ron Desantis’ eligibility requirements for Florida opening to ages 18 and up.
Quarantine numbers rose steadily in the last week, increasing from 411 people in isolation March 22 to 497 Monday. On-campus quarantine availability remained between 95% and 96% until it dropped to 94% on Tuesday.
UF Health Shands Hospital had 9.62% adult ICU availability (25 beds) on Tuesday, and North Florida Regional Medical Center had 14.58% (7 beds), according to the Agency for Health Care Administration of Florida.
A total of 77,196, or about 29% of county residents, have been vaccinated in Alachua County as of Tuesday, according to the Alachua County COVID-19 dashboard. Of these residents, 27,961 have received one dose and 49,325 have received two.
Contact Manny Rea at firstname.lastname@example.org. Follow him on Twitter @ReaManny.
Manny Rea is a journalism sophomore and the current health reporter for The Alligator. He worked as a copy editor in his freshman year before moving over to the Avenue in summer 2020. He likes to listen to dollar-bin records and read comics, and he is patiently waiting to go back to movies and concerts.


text:
Connect The Dots
Junious Ricardo Stanton
“Executives at the largest insurance companies in the United States are alarmed that teenagers, young and white-collar Americans in the prime of life are inexplicably dying at a record pace, causing a ‘monumental outflow’ of death claims and drag on profits that is shaking the industry and causing some to take a fresh look at the problem.” Insurance Execs Alarmed by Surge in Deaths Among Young People-But Stops Short of Blaming COVID Shots Mike Capuzzo https://childrenshealthdefense.org/defender/surge-young-people-deaths-insurance-industry/
We are in the midst of an observable and alarming phenomena, the rise in excess mortality all around the world within the past few years; yet no one is making the linkage to nor addressing the huge elephant in the room, the mRNA COVID shots! The term “died suddenly” where seemingly healthy folks of all ages died unexpectedly after getting a shot or a series of boosters has been in play since the roll out of these shoots. https://childrenshealthdefense.org/defender/myocarditis-death-covid-vaccines-risk-greater/ , https://www.kff.org/policy-watch/why-do-vaccinated-people-represent-most-covid-19-deaths-right-now/ , https://www.reuters.com/world/us/heart-inflammation-after-covid-19-shots-higher-than-expected-study-us-military-2021-06-29/
The government, media and pharmaceutical cartels are deliberately suppressing and downplaying the truth about these concoctions. The misnomered “fact checkers” who are actually in the employ and on the payroll of the media and corporations are trying to create the belief the COVID shots are safe and effective and anyone who disagrees is spreading “misinformation” and “disinformation” or is an anti-science, anti-vaxxer. https://articles.mercola.com/sites/articles/archive/2023/11/08/pharma-funded-fact-checkers-control-internet.aspx
The truth is we are being lied to on a massive scale. “The media (TV, newspapers, magazines, etc), medical societies, state medical boards and the owners of social media have appointed themselves to be the sole source of information concerning this so-called ‘pandemic’. Websites have been removed, highly credentialed and experienced clinical doctors and scientific experts in the field of infectious diseases have been demonized, careers have been destroyed and all dissenting information has been labeled ‘misinformation’ and ‘dangerous lies’, even when sourced from top experts in the fields of virology, infectious diseases, pulmonary critical care, and epidemiology. These blackouts of truth occur even when this information is backed by extensive scientific citations from some of the most qualified medical specialists in the world. Incredibly, even individuals, such as Dr. Michael Yeadon, a retired ex-Chief Scientist, and vice-president for the science division of Pfizer Pharmaceutical company in the UK, who charged the company with making an extremely dangerous vaccine, is ignored and demonized. Further, he, along with other highly qualified scientists have stated that no one should take this vaccine…
We are now witnessing a growing number of excellent scientific papers, written by top experts in the field, being retracted from major medical and scientific journals weeks, months and even years after publication. A careful review indicates that in far too many instances the authors dared question accepted dogma by the controllers of scientific publications—especially concerning the safety, alternative treatments or efficacy of vaccines. These journals rely on extensive adverting by pharmaceutical companies for their revenue. Several instances have occurred where powerful pharmaceutical companies exerted their influence on owners of these journals to remove articles that in any way question these companies’ products…
Television media receives the majority of its advertising budget from the international pharmaceutical companies—this creates an irresistible influence to report all concocted studies supporting their vaccines and other so-called treatments. In 2020 alone the pharmaceutical industries spent 6.56 billion dollars on such advertising. Pharma TV advertising amounted to 4.58 billion, an incredible 75% of their budget. That buys a lot of influence and control over the media. World famous experts within all fields of infectious diseases are excluded from media exposure and from social media should they in any way deviate against the concocted lies and distortions by the makers of these vaccines. In addition, these pharmaceutical companies spend tens of millions on social media advertising, with Pfizer leading the pack with $55 million in 2020.” COVID Update, What Is The Truth Russell L. Blaylock https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062939/
To add insult to injury these corporate fraudsters are blaming the “coronavirus” for the high rates of heart inflammation and other adverse effect rather than the shots; or they are lamely saying these adverse reactions and deaths are merely “coincidences”. Whew, you can’t make this stuff up!.
“Indeed, vaccinated people now make up the majority of the population – 79% of adults have completed at least the primary series – and the latest CDC data show that vaccinated people also now represent the majority of COVID-19 deaths. There are many more vaccinated people than there are unvaccinated people, and vaccinated and boosted people are, on average, older and more likely to have underlying health conditions that put them at risk for severe COVID-19 outcomes.” Why Do Vaccinated People Represent Most COVID-19 Deaths Right Now? Cynthia Cox, Krutika Amin, Jennifer Kates and Josh Michaud https://www.kff.org/policy-watch/why-do-vaccinated-people-represent-most-covid-19-deaths-right-now/ (Underline emphasis is mine.)
Do you remember when we were told by President Joe Biden and others, “Just take the shot, you won’t get COVID, you won’t have to go to the hospital and you won’t die.” That was a bodacious lie! Biden has supposedly been vaxxed and boostered yet he has gotten COVID several times but we aren’t supposed to remember that. The numbers don’t lie, people have been dying at inordinately higher rates since the introduction of these shots and those who survive are experiencing a myriad of adverse reactions! https://www.kff.org/policy-watch/why-do-vaccinated-people-represent-most-covid-19-deaths-right-now/ But the lame stream media is saying these are “rare incidents” and are downplaying the obvious connection between the shots and the adverse reactions because adverse reactions are not widely reported. People are suffering in silence, not reporting their conditions and when they do their doctors deflect and blame something else.
Yet Pfizer’s own internal documents tell a different story, Pfizer knew their concoctions were not safe! Freedom of Information requests have forced them to reveal the truth! https://www.globalresearch.ca/pfizer-data-attached-393-pages-adverse-events/5820870 https://www.globalresearch.ca/pfizer-vaccine-only-has-1291-side-effects/5773091 Autopsies are showing a causal relationship between the COVID shots and excess deaths even though many people also have comorbidities (Orwellian doublespeak for folks are already sick) which also are factors. https://zenodo.org/records/8120771 https://childrenshealthdefense.org/defender/vaers-covid-vaccines-canadian-woman-dies-bivalent-booster-shot/
But those studies are being suppressed and censored to keep us ignorant. They want us to keep taking the shots but the number of people taking the shots and boosters is declining which is a good thing. https://www.news-medical.net/news/20231005/Why-are-most-Americans-skipping-the-COVID-19-booster.aspx#:~:text=The%20analysis%20revealed%20that%20misinformation,reasons%20for%20vaccine%20booster%20aversion. The media is saying this is due to “misinformation” but in reality it is because people are waking up to the dangers of these shots.
We all know someone who has “died suddenly” or who has had an adverse reaction to the COVID shots and boosters. It’s time to connect the dots.

domain: medical


The Boeing Dreamliner, heading from Delhi to Hong Kong, was diverted after the pilots noticed a technical snag.
The plane landed safely.
All 216 passengers and 10 crew members aboard remained unhurt.
U.S. Flight Attendant Diagnosed With Monkeypox Believes He Was Infected With Virus On a Plane or a ‘Dirty Hotel’
Human rights defenders demanded the immediate release of the crew and the return of the plane to the Boliviarian government.


Lodge added to Arkansas historic properties list
CASSCOE, Ark. (AP) - A duck hunting lodge in eastern Arkansas has been added to the Arkansas Register of Historic Places.
The Lion Oil Company duck hunting lodge is on Arkansas Game and Fish Foundation property at Cook's Lake near Casscoe.
The Arkansas Game and Fish Commission says the lodge is one of three historic properties recognized for contributions to the state's duck hunting legacy. The other two properties are Wingmead near DeValls Bluff and the Crockett's Bluff Hunting Lodge in Arkansas County.
The Game and Fish Commission says actor John Wayne and President George H.W. Bush are among those who've stayed at the Lion Oil Company lodge.Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Organic Arrabbiata Tomato Sauce
1 Jar (200g)
Alce Nero tomato and porcini mushroom sauce is made from elongated tomatoes, including Coimbra, Ercole, and other varieties, which are grown on approximately 30 farms in the Po Delta in the provinces of Ferrara and Ravenna.
The tomatoes, which are harvested in July, August, and September at just the right level of ripeness, are processed within eight hours on average in order to preserve all the flavour, aroma, and nutrients. Once they’ve been washed and selected, steam
Tomato* (72%) (tomato purée*, tomato concentrate*), porcini mushrooms* (Boletus edulis) (9%), onion*, extra-virgin olive oil* (6%), dried porcini mushrooms* (Boletus edulis) (2%), carrot*, cane sugar*, salt, garlic*, pepper*. *organic.
Store in a cool, dry space. Once opened keep refrigerated.
Minimum 120 days
Alce Nero is a company made up of organic farmers and producers, many of them shareholders, involved in every step of

domain: agronomy


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Table of Contents
Helped living is a lasting living alternative designed for senior citizens that require some assist with tasks of day-to-day living (ADLs). Locals of assisted living neighborhoods live as separately as they're able, yet with the expertise that aiding hands are never ever also far. Helped living communities have actually educated workers on-site around-the-clock to assist locals with their ADLs.
Those living with memory disability might not have the ability to receive the customized focus as well as cognitive stimulation that they require in an assisted living facility setting. As with nursing home, some but not all taking care of residences might have a special memory care device or have actually trained memory treatment staff. Regardless of which kind of elderly care facility you're exploring, it is necessary to inquire about employee' level of memory treatment understanding as well as training if you have an aging parent with mental deterioration or Alzheimer's condition.
Some facilities assist prepare for needed physical, job-related or speech therapy. They might have therapists onsite or on-call.: Make certain the center can accommodate any kind of unique needs.
Take into consideration which facility supplies the services that you as well as the individual with mental deterioration need. Alzheimers Care Desert Hot Springs, CA. Think about using its solutions at least twice a week for a month prior to making a last decision.
At some point the person with Alzheimer's may require more treatment than the facility can give. Personnel and assistance groups can help assess your requirements for future care. What types of health care specialists are on team?
Make sure to inquire about standard costs, economic assistance and also extra costs for such solutions as crafts or day trip.
A person with dementia will certainly need more care as signs intensify gradually. Troubles with memory, assuming, and also behavior often present challenges for those with dementia in addition to for their household participants. Whether the illness remains in very early or late stages, there are support group, sources, as well as solutions that can help.
When it comes to caregiving, taking treatment of on your own is one of the most crucial things you can do. Explore the pointers and also resources listed below to discover information regarding mental deterioration care and also regional solutions. There are various kinds of treatment available depending on the level helpful or treatment you need.
These choices offer temporary look after a person with mental deterioration and also enable the caretaker to pause. Daily assistance may include supervision, meals provided to the house, and/or transport. may be provided by unpaid relative and also pals or by paid service providers as well as can entail general care or medical treatment.
Residence health treatment solutions include accredited physician and need a medical professional's order - Home Care For Alzheimer's Patients Desert Hot Springs, CA. may become required as a person with mental deterioration calls for more care as well as supervision than can be offered in the house. Aided living centers may have the ability to provide sufficient assistance in the very early phases of dementia, whereas assisted living facility might be extra ideal for people who are no more able to live safely at residence.
A homeowner can move between multiple levels of treatment as needed. These solutions can be gotten in the home or at a household care center, healthcare facility, or hospice facility.
Getting in touch with them is a good place to start. can collaborate to share responsibilities and also give breaks for the primary caregiver. are specialists that can suggest needed services as well as aid you get them. of an individual with mental deterioration recognize the illness and degree of care required and can supply suggestions on exactly how to satisfy those demands.
Federal government programs may have the ability to aid with some costs associated with dementia treatment. The Centers for Medicare & Medicaid Solutions' Program of All-Inclusive Treatment for the Elderly (RATE) might cover some or all of the long-lasting care needs of an individual with dementia living in the community.
is an additional source that enables you to browse for federal advantages. Whether you or your liked one simply needs an aiding hand or even more formal treatment, it is very important to know that help is available. What steps can you take currently to get ready for health care, financing, lasting treatment, as well as end-of-life choices?.
We actually want to send you the info, however we require to understand that and also where to send it to. Please enter your e-mail address so that we understand where send you the info.
Please correct it. We intend to be able to respond to any type of inquiries you may have. Please enter your telephone number, beginning with location code. If you prefer to get all info by phone, please phone call (888) 319-7682. You are almost there. Please provide your actual telephone number. We value your personal privacy.
Your consent is not required to make use of the service.
Memory treatment refers to caring for an individual with memory care concerns. Mental deterioration treatment refers to care facilities that particularly take care of those individuals (typically senior) that have some fort of dementia.
alone. When you ask on your own, "just how do I find memory care centers near me?" - it is vital to research study thoroughly so that you discover a facility dedicated to memory care living that can manage your enjoyed one's circumstance. If you care for a senior that has Alzheimer's disease or mental deterioration, finding a memory treatment facility as well as transferring them to this Alzheimer's and also Memory Care Center might help you in several means.
Why would you trouble yourself when there are specialists who are willing to provide expert aid to your liked one? It's apparent that living with a partner or close loved one that has actually created any kind of mental deterioration is particular to have a substantial result on your efficiency levels at job or your grades if you are in school.Alzheimers Care Near Me Desert Hot Springs, CA
Table of Contents
Alzheimer Caregiver Desert Hot Springs, CA
Care For Seniors Desert Hot Springs, CA
Home Health Near Me Desert Hot Springs, CA


Jan 14, 2019
Here are the bullet points of the week: Chris hunkers down for a winter storm, ABC's "American Housewife", Rob has a new toy idea, 50th anniversary of Woodstock, 90's pop, the differences in Chris, Rob and John's personal schedules, and Rob has a new theory
Jan 7, 2019
The boys discuss how completely different their New Year's Eve's were this year and Chris drinks the infamously old "The Don Jalapeno". Rather than set any new resolutions this year, they decide to revisit last year's and see how they did.
All that, and virtual reality.
Dec 31, 2018
Rob is in town, Chris is a tourist in his own city, and they tell John all about it. If you couldn't tell by the title, and are somehow reading this, we're impressed, but we went to the National Comedy Center in good old Jamestown, NY! Spoiler alert: it was awesome!!
Dec 24, 2018
This week, Chris tries to recapture the childhood Christmas spirit as Rob turns 40. They also come up with a great holiday spectacular, that unbeknownst to them, already exists and they open up and take a deep dive into their feels.
Dec 17, 2018
This week, niche YouTube channels, concert ticket memory lane, the upcoming Epicenter Festival, and Rolling Stone's Top 20 Metal Albums of 2018.
.....and of course, other shenanigans.


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It's been said many times before, your best education on fine tuning your images is by printing. I don't mean 4x6s at Costco, I mean printing at least 10x15 or larger. Everything is evident at these sizes - color, tonality, detail, shadow, highlights, sharpness...I mean everything. Prints don't lie. They are the moment of truth for your work. Plan on spending a lot of time, paper, and ink on getting the output the way you want it. Every variable imaginable comes into play...color management, paper, your mood...so get ready to be schooled!
I've just finished printing 9 - 11x16.5 prints for my Art Walk opening on Wednesday. Worked on it all weekend. I guess an artist's work is never done. I can keep iterating on these prints forever. Knowing that each trip trough the machine is costing me about $3, that's as bad as Starbucks. I need to find a way to sell these "artist proofs," more like "artist goofs" if you ask me. You hate to throw them away, maybe a gift for Uncle Stanley, he won't notice that there is a slight red cast on the bridge image...
Here is the little promo piece I made for the showing. Since I'm tucked back in the closet I need some signs so my friends can find me. Next item to tackle is the pricing. Need to factor in the cost of the goofs for sure, and the mats, frames, time for printing...oh and the trip expenses to get the image, all the workshops to learn how to do this stuff, my camera equipment...looks like $3,000 an image should cover that nicely. How's that for recession pricing?
How is your printmaking coming along? Don't settle for "good for the web". If you're making images as art, your art is your image...your PRINTED image. That printer in the corner of your studio is probably pretty lonely. Fire it up and make some prints, improve your images, and have something to show all your friends (and most importantly YOURSELF) that yes, you can produce a print.

domain: artistic


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Young Adult Fiction
If I am going to be honest right from the get-go, Shadow and Bone by Leigh Bardugo is one hell of a fantastic adventure. It follows the story of an orphan named Alina Starkov, who is taken from obscurity and her only friend, Mal, to become one of the Darkling's apprentice. He takes her to the Little Palace to provide her some shelter as she trains her power to summon the Sun. But everything is not what Alina is led to believe . . .

domain: library


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School. A place where we send our children for an education. But are they receiving a “social” education beyond social studies? According to Stopbullying.gov.org, most bullying takes place in school, on school grounds, and on the school bus.
Here’s one mom’s story of advice she gave to her daughter in regards to being bullied and how to deal with it.
Published by cbcarpenter
I am a wife, mother, grandmother, sister, daughter, niece, aunt, copy editor, friend, lover, reader, and avid writer. I became a teen mom at the age of sixteen, and grandmother at the age of 32. I love to share my views on the world and pull from my life experiences, with the hope to help someone out there figure out this crazy thing we call life.
View all posts by cbcarpenter


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Recognition from 7th Education International World Congress meeting.
The 7th Education International (EI) World Congress meeting in Ottawa, Canada, from 21nd to 26th July 2015:
1. Human and trade union rights of workers and all people in Iran should be respected;
2. The Coordinating Council of the Iranian Teachers Trade Associations (CCITTA) is the EI’s affiliated organizations, and Mr. Mohammad Khaksari, the coordinator of the international Committee of the CCITTAs, is the communicators of the CCITTAs with EI;
3. Strong, free and democratic unions and social dialogue are essential to peace, rule of law, democracy and progress, EI considers that its affiliate (CCITTA) contributes to building civil society in Iran and strengthening quality education for all irrespective of gender, ethnic and social background or religion;
4. Despite many obstacles, teachers in Iran have succeeded to maintain union activism. Trade unionists are being targeted for their activism, and some have already spent years in unjustified detention;
5. EI works within the international labour movement to support education unions worldwide;
Mandates EI to:
6. Praise the courage of CCITTA leaders and activists to pursue their rights even though they are often persecuted through the state’s harassment, unequal professional treatment, torture, unlawful imprisonment, and even execution;
7. Continue to support, through capacity building and advocacy, the efforts of Iranian teachers and other workers to practice their internationally recognized their rights within independent, non-political, non-sectarian and democratic education trade union;
8. Advocate for the Government of Iran to end impunity and bring about justice by respecting internationally recognized rights standards, including the labour conventions guaranteeing freedom of association and right to collective bargaining, peaceful assembly, and education-related recommendations and agreements;
9. Request that the Government of Iran guarantees the rights of all education workers and unionists and promote quality public education for all;
10. Condemns any acts of intimidation targeting teachers and unionists of both gender;
11. Campaign for the release of teacher trade unionists unfairly imprisoned, such as Esmael Abdi, Ali Akbar Baghani, Mahmoud Bagheri, Rasoul Bodaghi, Alireza Ghanbari and Alireza Hashemi; and
12. Convene an international mission to Iran.


I can change the acceptance lvl but the how accepted is locked. Both chat notifications are both locked as well.
tap the arrow on the left or right side once and then accept the change. It will change.
I tested this and it works. The issue is the text display not changing
That was totally annoying, thanks all good.
@moderators can close
Edit: Support actually was supportive


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Lord, Make Me Broken…
I didn’t know this is what it would feel like to be broken. When I prayed that prayer, I didn’t know what I was praying. I prayed to be broken, so I could be healed. What does that even mean? They say “why fix something if it’s not broken?” Why pray to be broken so you can be healed?
About 2 years ago, the Lord was drawing me deeper to Him. I remember being on my face begging the Lord to break my heart for what breaks His. I didn’t know this is what it would feel like. I didn’t think about the “breaking” process, until now. The song “Keep Making Me”, by Sidewalk Prophets comes to mind. “Make me broken, so I can be healed, ‘Cause I’m so calloused and now I can’t feel. I want to run to You with my heart wide open. Make me broken. Make me empty so I can be filled. Cause I’m still holding onto my will. And I’m completed when you are with me. Make me empty. Until You are my one desire, until You are my true Love. Until You are my breath, my everything. Make me lonely so I can be Yours. Until I want no one more than You, Lord. Cause in the darkness I know you will hold me. Make me lonely.”
Who in their right mind would pray this prayer? I didn’t really know what I was praying for. Until this moment. Until relentless episodes of grief have hit during this new season of my life. I get it now. I get what broken is. I get what empty is. I get what lonely is.
And I am thankful.
Through the pain, confusion, tears, I am thankful to be broken, thankful to be empty, thankful to be lonely. Because that means I can see the Lord shine bigger in my life. I can feel His presence overpowering the brokenness, emptiness, and loneliness. I feel his love in an all-consuming way. When I am weak, His strength comes in and turns everything around for His glory. “But those who hope in the Lord will renew their strength. They will soar on wings like eagles; they will run and not grow weary, they will walk and not be faint.” Isaiah 40:31.
I don’t want to be “complete” in myself. I don’t want to be “full” in myself. I don’t want to be so distracted by this world that I don’t know what loneliness feels like. If I didn’t experience life altering brokenness, I wouldn’t be experiencing the depths of God’s Love. I wouldn’t be able to witness firsthand Him build something beautiful out of the broken pieces. After all He is the Master creator.
Walking this faith journey has made me more sensitive to real things. By “real things” I mean getting out of the way of God’s plan. I mean stepping out of my comfort zone when He calls me to do so. I mean helping others even when I may not feel like it. I mean getting myself off my mind, even on a grieving day. I mean trusting in God when I see only darkness surrounding me. Those are real things.
Jessica is weak. Jessica is broken. Jessica is empty.
With God, Jessica is strong.
With God, Jessica is made whole.
With God, Jessica is filled up.
It is a freeing place to be to admit I am weak, broken and empty. I am nothing without God.
“But he said to me, “My grace is sufficient for you, for my power is made perfect in weakness.” Therefore I will boast all the more gladly about my weaknesses, so that Christ’s power may rest on me. That is why, for Christ’s sake, I delight in weaknesses, in insults, in hardships, in persecutions, in difficulties. For when I am weak, then I am strong.” 2 Corinthians 12:9-10.
Make me broken.
I Trust my God, I Trust my God, I Trust my God.


A motorcycle is the most convenient mode of transport. It is small, light and can let you through heavy traffic. Most of the people in countries like Nepal, India, and other South Asian countries prefer bikes as their main mode of transportation. However, the major concern to people who own a bike is the increasing cost of fuel. Fuel economy and mileage is the primary concern for people while purchasing a bike. Here is the list of top 10 bikes with the highest mileage in today’s market.
Top 5 Bikes With Highest Mileage
- TVS Sports: TVS sports should be the first pick to anyone who wants to purchase a bike with highest mileage. This bike gives a mileage of 95 kmpl. Consisting of 100 cc engine, TVS Sports was awarded the most fuel efficient bike of 2019.
- Bajaj Platina: Bajaj is a house hold name for motor bike lovers. Bajaj has produced some iconic bikes like Bajaj Pulsar. With the increasing demand of fuel efficient bikes, Bajaj has developed one of the best fuel efficient bike in Platina. Bajaj Platina features a 102 cc engine with a mileage of 90 kmpl.
- Hero Splender Pro: Hero Splender is one of the classic bikes in this category. It has a rich history and was considered one of the best buy in the 90’s. Today, Hero Splender Pro is still considered one of the top bikes with a mileage of 90 kmpl.
- Bajaj CT 100: Second Bajaj product in the list. Bajaj CT 100 is one of the bikes with highest mileage. With a 100 cc engine, you get a mileage of 89 kmpl from Bajaj CT 100. Almost similar with its Bajaj Companion.
- TVS Star City Plus: Second entry from TVS. TVS Start City Plus is one of the famous commuter motor bike with an impressive mileage of 86 kmpl.
Other 5 Top Bikes With Highest Mileage
- Hero Passion Pro i3s: Passion Pro i3s from Hero is one of the cheapest bike available in the market. Regardless its price, Hero Passion Pro i3s is known for its outstanding fuel economy with 84 kmpl.
- Honda Dream Yuga: Honda has always been known for developing modern, performance based and economical bikes. Like other Honda bikes, Honda Dream Yuga gives good performance from its 110 cc engine and is also largely economical with a mileage of 84 kmpl.
- Yamaha Saluto RX: Yamaha Saluto RX is the first entry in this list from Japanese Automobile manufacturer Yamaha. Known for its impressive pickup and acceleration, Yamaha Saluto RX also features a wonderful mileage of 82 kmpl.
- Hero Splender Plus: Another entry from Hero, Hero Splender Plus comes with a mileage of 81 kmpl. Unlike Hero Splender Pro, it comes a lot cheaper in the market.
- TVS Victor: Known for its smooth handling and power packed performance, TVS Victor is yet another entry in this list from TVS. Although, the highlight of this bike is its brilliant design, an excellent mileage of 70 kmpl is another reason to purchase this bike.
Here are the top 10 bikes with the highest mileage capability available in the market to buy.
Also Read: Top 5 Off Road Bikes in Nepal.


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Kim Kardashian explained her current fashion as “Foreseeable future Alien Barbie.”
She appeared at Condé Nast headquarters in a white tee and Balenciaga pantaboots.
Kardashian has spoken beforehand about struggling with her type soon after her divorce from Kanye West.
Kim Kardashian, who is at present sporting a platinum-blonde lob, explained her latest model aesthetic as “Potential Alien Barbie.”
Kardashian frequented Condé Nast while promoting her new skincare line, SKKN by Kim, on Tuesday, Vogue claimed. Through a discussion with Attract editor-in-chief Jessica Cruel, Kardashian set a label on her current manner sensibility.
“A very little futuristic,” she claimed, according to Condé Nast model Architectural Digest. “Upcoming Alien Barbie.”
According to Vogue, Kardashian wore a white Re/Carried out major and red, white, and blue patterned Balenciaga “pantaboots” (a shoe and tight pant mixed into one particular garment), which she also appeared in throughout her “Currently” clearly show job interview before in the day. Kardashian reported that when she does “struggle with everyday” appears to be, she’s having fun with being blonde and explained that she’s “owning extra enjoyable, Vogue reported.
Kardashian’s style has advanced about the several years as she’s moved from far more graphic prints to neutral, primary tones, Insider earlier documented. Her ex-spouse Ye, formerly identified as Kanye West, was also a key catalyst in transforming Kardashian’s design and style. On her Hulu sequence “The Kardashians,” Kardashian has also spoken about the panic that she often activities whilst styling herself.
“I would ask him for suggestions for all the things, down to what I don,” Kardashian mentioned of Ye in the show’s fifth episode. “Even now I’m possessing like, stress assaults, like, ‘What do I wear?'”
Kardashian explained on the episode that right after styling herself for the Wall Street Journal Journal Innovator Awards in November 2021, Ye named her soon after to tell her that her occupation was “in excess of” and confirmed her a “picture of Marge Simpson” donning a very similar garment to the Skims x Fendi leather-based dress that she wore to the function.
Study the original short article on Insider

domain: celebrity


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Dizzi is not just a camera app, its a powerful all-in-one video story maker. Go dizzily creative with a variety of pro camera modes! Set the right mood with eye-catching effects, vibrant filters, and funky tunes! Shoot your truly unforgettable stories and share them instantly with the world!
Capture all of your day-to-day fun and craziness!
No rules! No limits! Just be yourself and dont be afraid to experiment!
Tons of trendy, mind-blowing effects and modes. 100% awesomeness. Quickly and easily.
Add a thrill to any video with a variety of original, out-of-the-box effects:
Nostalgic about the past? Shoot with VCR, VHS, or 90s Tape.
Want to play with the way you see things? Use B&W + Color or try surreal INFRA and replace all green with another dreamlike color.
Crave some real change of scene? Turn on Torn Paper, Broken Glass, Smoke, Pop Art, or Water. Its so awesome and fun you wont be able to stop trying new combos!
Always dreamed of being a character of a sci-fi movie? Try real magic with AI-based Energy Push, Hologram, and Glitch!
Liven up the setting and create the right mood with colorful filters and overlays!
Want to stand out among hundreds of plain videos? Use these jaw-dropping camera modes:
Dolly Zoom zooms in or out the background of the shot while leaving the foreground unchanged. Just like in those Hollywood movies!
TimePlay combines multiple shots of a certain place into one smooth, speedy video. Push the boundaries of time!
Boomerang captures a short video and plays it forward and in reverse several times to create a marvelous loop.
2cam shoots with the front and back cameras simultaneously. Activate a selfie window or split the screen in two in a collage. Choose a live frame for the selfie window or try Chroma Key (cropping you out in real time and putting you in whatever environment youre shooting with the back camera).
Share your stories to TikTok, Instagram, Facebook, Snapchat, and Likee right from the app!
Record the sounds around you, comment on what youre shooting, add a tune, or mix them all!
Freshen your look before a shoot with just one tap.
Shoot like a pro with the advanced camera settings:
cinematic video stabilization,
exposure and focus control,
Use Siri Shortcuts to start shooting a new story instantly.
Need to stop a video but want to add something to it later? Film the next part and combine the clips into one cool video!
Have any questions or suggestions? Want to share your impressions? Any feedback is very welcome at email@example.com
Get Dizzi Premium
- 4 subscription options: weekly ($4.99, 3-day trial), monthly ($4.99), annual ($29.99), one-time ($49.99, once and forever). Please note that the price of a subscription may change.
- By subscribing you get unlimited access to all the apps functionality for the whole duration of your subscription period.
- Payment will be charged to iTunes Account at confirmation of purchase.
- Subscription automatically renews unless auto-renew is turned off at least 24-hours before the end of the current period.
- Account will be charged for renewal within 24 hours prior to the end of the current period. Free trial > $4.99/week, or renewal equals the initial subscription chosen and its current price unless a special price is offered.
- You can cancel a free trial, manage your subscription and turn off the auto-renewal anytime through your Account Settings. This must be done 24 hours before the end of a free trial or subscription period to avoid being charged.
- As soon as you purchase a subscription, any unused part or time-span of a free trial period will be forfeited.
Shop your favorite products and we’ll find the best deal with a single click. Designed to make shopping easier.


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Before bikes were even invented, the popular Wiggle bike route was a foot trail to avoid these same hills. The very latest research on Mission Dolores suggest it was founded in the Wiggle. Later, the city expanded to fill the valley with houses, but why? And what was there first?
Change the way you see the landscape as we talk about everything from art and bike politics to floods, lakes and native societies. A quintessential mix of Thinkwalks themes.
Details: A flat one mile walk (each way). Meet at the Bike Mural, Duboce Avenue at Church Street, behind Safeway at 11:45am. Ends at Divisadero Street 2 hours later.
Aaron was the editor of Streetsblog San Francisco from January 2012 until October 2015. He joined Streetsblog in 2010 after studying rhetoric and political communication at SF State University and spending a semester in Denmark.


King Leonidas' bike of choice, the Spartan is a hardy upslope annihilator and a battle-proven singletrack soldier. Along with a negative opinion of Persians, the Spartan also comes equipped with an uber-stiff aluminum frame, 165mm of Split Pivot suspension, and 27.5-inch wheel compatibility. The rigid frame and incredibly responsive suspension system make this bike the missing link between your unfettered freeride reign and the burgeoning world of Enduro racing. Ha-ooh!
|Frame||Devinci Aluminum Optimum G04, 165mm-travel, 142 x 12mm thru-axle|
|Headset||FSA Orbit 1.5 Zero Stack|
|Rear Shock||Rock Shox Monarch Plus RC3 8.5x2.0|
|Seat Binder||Alloy CNC 34.9mm Black|
* Subject to change without notice.