The iPhone 12 and iPhone 12 Pro were officially released by Apple. In this comparison, we have noted the differences between these two models to help you make your choice, without forgetting to take your budget into account. Find out which new iPhone is right for you.
Finally ! After a few weeks of delay compared to the initial schedule due to delays in the production chain caused by the COVID-19 epidemic, Apple finally launched the iPhone 12 series on October 13, 2020. And a question then arises for de many consumers eager to acquire one of these new iOS smartphones. Which one to choose ? A question to which we try to provide answers in this comparison between the iPhone 12 and the iPhone 12 Pro.
IPhone 12 and iPhone 12 Pro data sheet
Let’s start with a general overview of the forces involved with a summary of the technical sheet of the two devices.
|iPhone 12||iPhone 12 Pro|
Super Retina OLED
1242 x 2688 pixels, 19.5: 9 ratio
Super Retina XDR OLED
1242 x 2688 pixels, 19.5: 9 ratio
|Chipset||A14 (5nm)||A14 (5nm)|
|BONE||iOS 14||iOS 14|
|Storage||64/128 / 256GB||128/256/512 GB|
|Main sensor||12 MP, f / 1.8
12 MP, f / 2.2
|12 MP, f / 1.8
12 MP, f / 1.8
12 MP, f / 2.2
3D LiDAR scanner
|Selfie sensor||12 MP, f / 2.2||12 MP, f / 2.2|
Fast charge 18W
Fast charge 18W
|Biometrics||Face ID||Face ID|
IPhone 12 Pro in metal, iPhone 12 in aluminum
Overall, the design of the iPhone 12 and iPhone 12 Pro is similar. The two mobiles benefit from the reduction in the size of the notch. Apple eventually managed to make it less prominent. But the powerful 3D scanners of Face ID oblige, the notch is still retained. The location of the physical buttons is the same.
The two smartphones share the same dimensions: 146.7mm in height, 71.5mm in width, and a thickness of 7.4mm. Only the weight varies slightly between the two devices: 162g for the iPhone 12 against 187g for the iPhone 12 Pro.
From an aesthetic point of view, it is difficult to differentiate the two models. We note all the same that with its metal frame, the iPhone 12 Pro benefits from better finishes than the iPhone 12, which is “content” with an aluminum frame. Note that users will be able to choose from a rather wide range of colors :
- iPhone 12: black, white, blue, red and green
- iPhone 12 Pro: Gray, Steel, Gold and Blue new generation
Important precision, both smartphones are certified IP68, that is, they are protected against splash, water and dust. According to Apple, the iPhone 12 and iPhone 12 Pro will be able to withstand submersion up to 6 meters deep, for up to 30 minutes.
Almost identical screens
The screen of the iPhone 12 and iPhone 12 Pro is not a very differentiating element between the two smartphones. We find the same 6.1-inch diagonal, with OLED technology at work in both cases. Apple’s two newborns take a slab Super Retina XDR developed by Samsung.
In other words, we find the same image definition of 2532 x 1770 pixels, 460 ppi and a similar ratio of 19.5: 9. Both smartphones are also Dolby Vision, HDR 10 and HLG compatible. A small difference is played on the maximum brightness: 625 nits for the iPhone 12 against 800 nits for the iPhone 12 Pro.
On one as on the other, we can regret the absence of a refresh rate of 120 Hz. Apple would have considered that such a feature drained too much battery. However, the 5G which arrives with the iPhone 12 will already put a blow to their autonomy. In addition, both smartphones will be equipped with the latest creation from the company Corning, specializing in protective glasses. Indeed, the Ceramic Shield makes its debut on both devices. According to Apple, this glass offers exceptional protection, 4 times more resistant to falls. What to avoid accidents and clumsiness.
An A14 SoC engraved in 5nm
Regarding performance, we will have to wait for the benchmarks to get a clear idea of the difference between the two smartphones. But they should behave roughly the same since they are equipped with the same chip: the new A14, eagerly awaited since it is the first SoC engraved in 5nm on the market.
The iPhone 12 and iPhone 12 Pro are both extremely fast (+ 20% compared to the iPhone 11), and this even more impressive engraving fineness than on previous generations makes it possible to offer an unequaled performance / energy efficiency ratio. Apple promises a 50% performance gain compared to the main Android processors, such as the Snapdragon 865 for example. On the GPU side, the apple brand also promises a 50% increase in performance.
The iPhone 12 is however below for some tasks if the user is used to juggling a large number of applications because of its 4 GB RAM. The iPhone 12 Pro is doing better with its 6 GB of RAM. Regarding storage, no SD card slot to expand the memory, it is better not to make a mistake when choosing the configuration of your iPhone. There are variations 64, 128 and 256 GB for iPhone 12 and variants 128, 256 and 512 GB for the iPhone 12 Pro.
The first 5G compatible iPhones
Finally, both models are 5G compatible. Good news as operators will launch their 5G network in the coming weeks in France. Orange has even already communicated the prices and details of its 5G packages. But beware, the iPhone 12 is not able to use 5G as well as the Pro version. The iPhone 12 only supports Sub 6-GHz, that is to say the low and intermediate frequencies of 5G.
The iPhone 12 Pro is not only Sub 6-GHz compatible, but also mmWave, ie it can capture the high frequencies of 5G (greater than 24 GHz). In short, the iPhone 12 Pro can better capture 5G since it is able to pick it up over a larger spectrum of frequency bands, and can theoretically benefit from better speeds.
But for the beginnings of the 5G deployment, mmWave will be rare and it is Sub 6-GHz that will be dominant. In 2020 and for a few more years, mmWave compatibility is therefore far from essential. In addition, both smartphones will benefit from the Smart Data Mode, which allows your smartphone to go directly to 4G LTE if 5G is not necessary for your activities.
Equal play for autonomy
With their form factor and size so close, it’s no surprise that the iPhone 12 and iPhone 12 Pro come with a similar battery, 2775 mAh capacity. Given that they are equipped with the same SoC and a screen of the same size with the same definition and refresh rate, it is likely that the two smartphones offer very close autonomy.
Same observation for the 20W recharge shared by the two devices. It is certainly not very powerful compared to the Android competition in this price segment, but the size of the batteries being small, recharging is still done quickly. Apple promises 50% autonomy in just 30 minutes of charging. In video playback, this gives 17 hours of battery life for both devices, and up to 65 hours of audio playback.
Another point of size, the two smartphones will accommodate the new MagSafe technology. Apple intends to greatly improve wireless charging with this magnetic accessory, which allows the iPhone to perfectly align with the charging dock. Many magnetic devices stamped MagSafe will be launched, such as protective cases for example or a dual wireless charger for iPhone and Apple Watch.
The iPhone 12 Pro stands out in the photo
One of the biggest differences between the iPhone 12 and the iPhone 12 Pro is in the camera area. The first city is entitled to a double sensor composed of a 12 MP main wide-angle module and 12 MP ultra-wide-angle module also. A simple configuration that has proven itself on the iPhone 11.
To go further, we must turn to the iPhone 12 Pro, which is equipped with no less than four sensors on the back. We find the same wide-angle and ultra-wide-angle modules as on the iPhone 12, but to which we must add a telephoto improving the quality of zooms (2x optical zoom in, 2x optical zoom out, 10x digital zoom) and a 3D LiDAR scanner which acts as an advanced ToF (time-of-flight camera) module. LiDAR allows the iPhone 12 Pro to better understand the depth of field, with all that this implies in terms of improvements for many features: bokeh effect on portrait mode, augmented reality …
The iPhone 12 Pro also embeds a stabilization of a new kind, both in photo and video, for all of its sensors. A macro mode is also available thanks to the ultra-wide-angle module, more efficient than on the iPhone 12. It allows you to focus on a subject positioned very close to the lens. Users will also be able to take advantage of the Portrait mode in Night mode (from all sensors), as well as the all new Apple ProRAW.
According to Apple, this mode will combine the advantages of digital photography like Deep Fusion and Smart HDR with the flexibility of RAW photos. Via this mode, users will be able to modify their shots as they wish: sharpness, highlighting of certain colors, etc. For video enthusiasts, know that the iPhone 12 Pro is capable of filming in 4K at 120 or 240 frames per second, and is Dolby Vision HDR compatible.
On the front, we find on the two models a 12 MP photo sensor with f / 2.2 aperture. It is associated with Face ID 3D scanners, which in this generation is even faster and more practical. It becomes possible to unlock your iPhone from even more positions.
iOS 14 at the controls
Of course, both devices are releasing iOS 14, the latest major update to Apple’s mobile operating system. They should be entitled to an update to the next version of iOS every year for at least five years. Translation, ever better iMessages, picture-in-picture, widgets on the home screen, more efficient Siri… see our dossier on new features in iOS 14 to find out more about it.
IPhone 12 under 1000 €, iPhone 12 Pro from 1159 €
Now that we’ve reviewed the differences and commonalities of the two smartphones, let’s talk about budget. IPhone 12 is available from € 909, in its 64 GB variant. The price then changes to 959 € for iPhone 12 128 GB and € 1,079 for the iPhone 12 with 256 GB of storage space.
Contrary to previous rumors, the iPhone 12 Pro will not go below the 1000 € mark. Apple’s high-end device will be available from € 1159 in its 128 GB version, and € 1,279 for the 256 GB model. Users hungry for storage space can opt for the version with 512 GB, available at € 1509. The price difference is therefore very real, and will be a determining factor in your choice.
iPhone 12 or iPhone 12 Pro: which one to choose?
The iPhone 12 is for you if you only want to benefit from a new smartphone with a screen of more than 6 inches with iOS in paying as little as possible. The device is extremely powerful and fast and offers good battery life, it has the same SoC and the same battery as the iPhone 12 Pro.
The latter is more premium oriented with its metal frame. For those who need a lot of storage space, there is a 512 GB variant, where the iPhone 12 stops at 256 GB. It is mainly for its photo capabilities that it stands out from the crowd. the standard iPhone 12. Those who seek above all an excellent photophone will not regret investing more for the Pro model. The iPhone 12 is however sufficient if the photo is not your number 1 criterion.


Canada's vote against a United Nations declaration of aboriginal rights was an "astonishing" move for a country that claims to be a model of tolerance and diversity, says UN Human Rights Commissioner Louise Arbour.
"Canada claims to be an important player in the international community on the advancement of human rights," she said.
"You cannot play if you're not on the rink. You cannot play the whole game sitting on the side, positioning yourself as the arbiter of others' performance without putting your own into question."
Arbour called it a "very surprising position for Canada to take after not only years (but) decades of progressive involvement on that issue . . . . I found it rather astonishing."
Harper is making an impression:
Asked how the world views Canadians, she told the media,"There is a sense that Canada is moving away from its total commitment to multilateralism and is now, I think, advancing other forms of either national or regional alliances."
Damaging Canada's reputation, free lancing, undermining, basically a rogue entity that doesn't play well with others. The sense of pride we should all feel, as Canada "astonishes" the world.
In fairness, I should acknowledge that Canada is back in one sense, taking its cues from Washington.
And soon, if Harper gets his jamority, we'll really be back -- to the 1950s (well, not Uncle Louis' 1950s, that would be sweet - woollen sweaters for everyone during the winter months, a 53 Dodge in the driveway waiting to take us to Uncle Beryl and Aunt Sally's for Dominion day... I guess it would be more like Vice President Nixon's 1950s).
It is very likely that a Liberal government would have voted against this as well, since it does have some interesting things to say about aboriginal title to land.
I.E. that legal documents between two nations that extinguished legal title of aboriginal land are null and void and that the original title still exists.
Wouldn't be too good for Canada to acknowledge that eh?
Canada was joined in voting against by other western nations that used the treaty process flowing from the Royal Proclamation of October 7, 1763.
You simply can't undo 300 years of law and agreements to be on 'the right side of world opinion'.
The rights and freedoms granted to natives by the Proclamation are protected by the Charter of Rights and Freedoms.
Leaving aside the substance of what Arbour said, I'd just like to say that I think it's interesting that the last two major "international officials" to make this sort of intervention in Canadian political life using international opinion as an influencing tool have been Canadians -- Arbour at the UNHCR and Ray Henault at NATO.
I think that (a) that's kinda cool, and (b) they feel much more comfortable about throwing their weight around in their home countries, even given the hats they're wearing right now.
As it happens, I agree with Henault and not with Arbour, but I thought the parallel between their roles and their interventions into Canadian domestic politics was interesting.
As for Harper on the international stage, my impression is that he impresses with his demeanour, knowledge, and diplomatic skills, but that he also has an unfortunate tendency to air dirty domestic (political) laundry there too.
Don't forget that there is no report from Wajid Khan's visits to the Middle East becuase he found that things were not favourable for Harper and that although Merkel said the right statesmanlike things at the G8 Summit (a useless event) the German people were totally unhappy with Harper.
Harper's always pounding on his chest - but as they say "empty wagons rattle the most".
It's more like Canada's leaving - not Canada's back.
Other than the conseradroids who proudly state Harper is bringing Canada back to the world stage, who is actually saying that?
I really do not know what they are talking about when they say that. Are they suggesting that no other PM before Harper ever attended international events/meetings/summits? Is he the only Canadian PM to speak at the UN of something?
The resolution itself was drafted by Canada under the Liberals (which likely explains why the Cons voted against it), so likely as not, the Libs would have supported it.
The resolution was also a symbolic, non binding one, not a full blown treaty. It would have had little or no effect on current land claims or title, other than to demonstrate a respect and willingness on behalf of the Federal government to negotiate in good faith.
Instead, what we have is the same government that reneged on the Kelowna Accord demonstrating once again it doesn't care one shit about natives or their rights in this country.
Do you think that will make future negotiations easier or harder?
And out of curiosity, which "two nations" do you refer to and which part of the resolution do you refer to?
Canada was joined in voting against this by racists thugs like John Howard's Conservatives in Australia and the US, who are in the process of trying to destroy their aboriginal people.
"It is very likely that a Liberal government would have voted against this as well"
Complete rubbish. If you ask anyone involved in the process, Canada was considered "instrumental", "influentially", "fully engaged", helping to craft the final text which came up for a vote.
Well at least they weren't alone. Australia and the U.S. voted against it too. Hmmm...
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Last Updated: Saturday, July 05, 2014, 16:53
Central paramilitary and state forces, along with health workers, have fanned out in Tripura while a helicopter has also been pressed into service to control malaria.
Last Updated: Saturday, July 05, 2014, 13:00
Believe it or not, kidnapping has become the order of the day in the insurgency-hit Garo Hills region of Meghalaya, with one person being abducted every alternate day in the past six months.
Last Updated: Saturday, July 05, 2014, 11:17
Crimes against women in six of the eight northeastern states increased significantly in the last year compared to the year before as Assam led the list, although Manipur and Mizoram registered a downward trend.
Last Updated: Friday, July 04, 2014, 15:57
The landlocked Tripura was cut-off from the rest of the country by road as a large portion of National Highway-44 was damaged in Assam due to the rains, a minister said.
Last Updated: Friday, July 04, 2014, 00:58
Democratic Alliance of Nagaland government has requested the Centre to appoint a new interlocutor while the state government would continue as `facilitator` for finding an acceptable solution to the vexed Naga political issue.
Last Updated: Thursday, July 03, 2014, 15:34
Union HRD Ministry has assured Arunachal Pradesh of extending all possible help for setting up model schools in educationally backward blocks of the state.
Last Updated: Thursday, July 03, 2014, 15:17
Security forces have found a large number of weapons from the interiors of Bishenpur district in Manipur, police said on Thursday.
Last Updated: Thursday, July 03, 2014, 15:15
Two CRPF commandos were critically injured when they were attacked by suspected Garo tribal militants in North Garo Hills district in Meghalaya on Thursday, police said.
Last Updated: Wednesday, July 02, 2014, 16:08
Union Finance Minister Arun Jaitley has agreed to an integrated package to usher in holistic development in the border areas of Arunachal Pradesh, an official release said here Wednesday.
Last Updated: Wednesday, July 02, 2014, 16:02
Mizoram Chief Minister Lal Thanhawla has sought union Home Minister Rajnath Singh`s intervention to resolve the Assam-Mizoram boundary dispute, an official said.
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In 2011 India decided to purchase eight more LCU (Landing Craft Utility) amphibious ships, to be designed and produced locally. The first of these Mk IV LCUs entered service in early 2017 and the fourth recently did so, forty years after the first Indian built Mk I LCU entered service. That LCU retired in 2011 after nearly four decades of service. The two Mk 1s were followed by three Mk IIs in the early 1980s. In the late 1980s, there were four Mk IIIs, which are still in service but will be gone when the remaining four Mk IVs arrive in the next few years.
Each class of Indian LCUs were a bit larger and more capable. LCUs were developed during World War II, and are still in wide use by nations that have lots of coastline, or nearby islands. That is India’s situation, with many islands and an enormous coastline. Indian LCUs spend most of their time dealing with natural disasters and other non-military emergencies. That is common with LCUs worldwide. But all of them tend to practice their military capabilities regularly.
The Mk IVs displace 1,000 tons loaded and are capable of landing cargo and vehicles right onto a beach. LCUs have a flat bottom and a ramp built into the front of the ship, which can be dropped into shallow water to allow armored vehicles or even tanks to leave the ship and move right onto the beach, or a pier. The Mk IVs are 63 meters (206 feet) long, have a top speed of 28 kilometers an hour and a range of 2,800 kilometers when cruising at 22 kilometers an hour. There is a crew of 56 and space for 160 troops and 145 tons of cargo or equipment. That means one heavy (65 ton) tank can be carried or four smaller armored vehicles. About 24 20 foot cargo containers can be stacked aboard. Armament is two 30mm autocannon, a 12.7mm machine-gun, several 7.62mm machine-guns and some shoulder fired portable surface to air missiles. Each Mk IV costs less than $80 million.
India has long had problems designing and building larger warships (frigates, carriers, subs). For decades India blamed colonialism for the decline of the Indian shipbuilding industry. But after other nations, with even less history of shipbuilding (China, South Korea), became world leaders in the industry Indians began to accept that the problems were Indian and not the fault of British colonialism (which brought the industrial revolution to India, where that industrialization process declined after the British left). By the 1990s the Indian government agreed that internal reforms were needed and since then India has made a lot of progress but is still way behind countries like China, Taiwan and South Korea in shipbuilding and new tech in general. The construction of smaller ships was another matter and Indian shipyards had been building those vessels for thousands of years but the introduction of all-metal commercial ships in the 19th century enabled many other nations to surpass India as a major ship builder.


By Blue Mountain College Media Relations
BLUE MOUNTAIN – A trio of Blue Mountain College players have been named Daktronics-NAIA Division I Scholar Athletes.
Shayne Adams, Ryan Howell and Brad Pressley were among 67 NAIA players selected for the national honor.
Adams is a senior secondary education and biology major from Sherman who played for North Pontotoc High. Howell is a junior business administration major from Booneville. Pressley is a senior pre-med student majoring in biology from Wheeler.
A student-athlete must maintain a minimum grade point average of 3.5 on a 4.0 scale and have achieved junior academic status to qualify for the honor.
The three from BMC, a member of the TranSouth Athletic Conference, were the most of any league school.


Rick Rowand recaps Game 1 of the ALDS between the Boston Red Sox and the Cleveland Indians in which playoff Tito bested the Red Sox.
Dave McCullough takes a look at the landscape for the 2016 AL Cy Young award to see if there is a clear-cut winner or if it will come down to the wire.
Dave McCullough wonders if Boston Red Sox skipper John Farrell can overcome the bias against him from his hometown fans to win the AL Manager of the Year Award?
Ian York uses PITCHf/x to analyze Sandy Leon’s framing to determine if the catcher has made any improvements behind the plate.
Dave McCullough lays out the case for Rick Porcello as the ace of the Boston Red Sox staff as he continues piling up wins and putting up an impressive ERA.


The Chinese tech giant Huawei has secured the second spot in the smartphone market, beating Apple in the first quarter of this year. According to the data shared by the Chinese-owned International Data Corporation, Huawei outsold Apple’s iPhones seizing the Cupertino giant’s second place in 2019.
The data shared by the Chinese company reveals that a total of 310.8 million smartphones were shipped worldwide in the first three months of 2019, which is a 6.6% decline as compared to the same period in 2018. This makes it the sixth consecutive quarter of decline for global smartphone shipments.
IDC data shows that apart from Huawei‘s strong growth the smartphone shipments will see another low year in 2019. Ryan Reith, the director of IDC’s mobile device program said, “The overall smartphone market continues to be challenged in almost all areas, yet Huawei was able to grow shipments by 50%. It is becoming increasingly clear that Huawei is laser-focused on growing its stature in the world of mobile devices, with smartphones being its lead horse”.
Huawei managed to secure a 50.3% growth to ship 59.1 million smartphones, putting the Chinese company within striking distance of Samsung which is currently dominating the smartphone market worldwide.
Meanwhile, Samsung and Apple both saw a decline in the smartphone shipment. Samsung saw an 8.1% drop in smartphone shipments to 71.9 million in the first quarter and Apple with a challenging first quarter, saw iPhone shipments dropping by a 30.2% in 2019.
The overall downfall in the high-end smartphone market shows that people are waiting longer to change their devices because the smartphone giants are not offering any captivating innovation to the users. IDC research manager Anthony Scarsella said, “Consumers continue to hold on to their phones longer than before as newer higher priced models offer little incentive to shell out top dollar to upgrade”.
Moreover, the pending arrival of 5G smartphones may also be a reason why consumers are holding on to their old smartphones instead of buying new ones.


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Nicholas Volker was not a healthy child. The doctors found that tiny holes opened on his skin. Worse still he had the same holes in his intestines, which spilled their contents into his abdomen. By the time he was three years old, he’d had over 100 surgeries. At the age of four, he weighed just seventeen pounds.
The medical team at the Children’s Hospital of Wisconsin were at their wits’ end. But they would not give up. Determined to get to the bottom of the problem they embarked upon an exercise that was, just ten years ago, long, uncertain and extremely expensive. They decided to sequence his DNA. They started by looking at individual genes known to be implicated in Crohn’s Disease and irritable bowel syndrome. They found no mutations.
So they expanded their search, to look at all the exons – the DNA strands that code for proteins. Single DNA reads are not entirely accurate, so to make sure they spotted any mutation they sequenced the DNA thirty-four times. Next they compared Nicholas’s DNA to the reference provided by the Human Genome Project. This threw up 16,000 variations. They trawled through these and eventually came to a gene called XIAP, which prevents the immune system from attacking the intestine. A single letter of its DNA was abnormal. Nicholas had an A (adenine) where others had a G (guanine).
Finally the doctors had the answer. Nicholas was given an umbilical cord blood transplant from an anonymous donor and has recovered to lead a reasonably normal life. Nobody born with Nicholas’s terrible illness could be called lucky. But he was fortunate that the doctors decided to devote the time, effort and dollars to sequence his DNA at a time when it was very expensive.
Gene sequencing is more than a promising new treatment. It’s a world changing, and investable, scientific breakthrough and it’s also set to change agriculture and farming.
The most important chart in genomics
To put this into context let us start back in 1977, when Sir Frederick Sanger invented the first method for reading DNA. Given the rapid advances in technology since then it is surprising that ‘Sanger Sequencing’ remained the standard method for thirty years.
But in 2005 Life Sciences (now part of Roche) launched its Genome Sequencer. Based upon ‘massively parallel’ sequencing this was able to read millions of fragments of DNA simultaneously – using the Sanger method the maximum was just 384. Post-Sanger technologies are collectively known as ‘Next Generation’ and although there are a number of different versions, they all use massive parallel sequencing.
The chart says it all:
Falling cost opens up new possibilities. Until now the cost of sequencing the entire genome of an organism has often been prohibitive. Instead, researchers have looked only at a specific region of interest. They have studied individual genes known to be related to disease, for example the BRCA1 and BRCA2 genes that are implicated in breast and ovarian cancer.
They have studied only the exons,(EXpressed regiONS) of the genome that collectively form the exome and, unlike the remaining 98.5% ‘junk’ DNA, code for proteins. This selective approach has uncovered some genetic causes of disease, especially in inherited ‘Mendelian’ diseases, and it has also been sufficient to transform forensics and bring criminals to justice. But we now understand that many diseases have many genetic triggers; that junk DNA may have a function after all; and that our genes are not so much a series of single transmitters but a network. So we want to see the whole genome, not just a part of it, and next generation sequencing makes this possible.
We are now seeing some ambitious projects. In England the University of Cambridge, Genomics England and ILLUMINA Inc have launched a three-year project to sequence the whole genome of 10,000 children and adults with rare genetic diseases. This marks the beginning of a national endeavour to sequence 100,000. In the USA Human Longevity Inc, backed by Craig Venter, intends to sequence up to 100,000 human genomes per year. This venture will also gather information on the microbiome (the microbes that live in and on the human body) and the metabolome (metabolites, biochemicals and lipids circulating throughout the human body). Armed with this mass of information the project aims to unravel the process of ageing and associated diseases like cancer, diabetes and dementia.
Eight things we’re learning from genetics science
The Venter and Cambridge studies will generate a torrent of data, spurring the development of bioinformatics, and should give a better understanding of the cause of disease. But advances in sequencing capability promise more than just these broad studies. Let me remind you of the applications of Next Generation Sequencing.
1) Defining rare disorders
Many diseases are thought to be caused by genetic flaws. In particular 80% of rare diseases have a genetic component and while each of these is uncommon, collectively there are some 6,000-8,000 rare diseases. One in seventeen of us will get a rare disease at some time in our lives and a survey in the USA has found that accurate diagnosis takes an average of 4.8 years.
Rare diseases that are inherited are known as Mendelian disorders, after the 19th century monk Gregor Mendel who established the principle of inheritance. The Online Mendelian Inheritance In Man (OMIM) website shows that we are able to pinpoint the molecular basis of an increasing number of inherited phenotypes (observable traits).
2) Describing cancer
Cancer is a major target of geneticists. All cancers are genetic and arise when genes within a normal cell are damaged or mutated, perhaps due to cigarette smoke or solar radiation. The key cancer genes are growth promoting genes (called proto-oncogenes); growth inhibiting genes (tumour suppressor genes) and genes whose function is to repair damaged DNA. And the number of mutations implicated in cancer has grown exponentially over the last two years.
However cancer is not the result of a single mutation. Multiple mutations in several key genes finally trigger uncontrolled cell growth and, since this takes time, it explains why cancer comes with old age. So researchers are increasingly looking for network effects as a number of specific genes interact. They are also sequencing the cancer cells themselves, a challenge complicated by the fact that tumours are not homogeneous and change over time.
3) Clinical trials & therapeutic selection
Next Generation Sequencing can be used to stratify patients for clinical trials. New drugs are approved on the basis first of safety and then efficacy. If a drug only works for one patient in ten it might not be approved. However if it works for one person in two, then it probably will be approved. For years researchers have been trying to achieve this outcome by improving drugs. However an easier route could be to identify only those patients likely to benefit. This is the basis of ‘stratified’ or ‘personalised’ medicine.
4) Carrier screening
Tay-Sachs is a debilitating neurological disease for which there is no known cure. It is an ‘autosomal recessive’ genetic disorder meaning that both parents can carry a particular genetic mutation without contracting the disease. However their child would have a 25% chance of contracting Tay-Sachs. Screening of the parent’s DNA can establish whether there is a risk, and inform the decision about childbirth or indeed whether to get married in the first place.
5) Pre-natal testing
Pre-Natal testing assesses whether babies are likely to be born with defects. Cells from the fetus are shed into the mother’s blood, and these can be captured for testing. At present tests are typically run only for high risk pregnancies and look for particular chromosomal disorders such as Down’s Syndrome, but as the cost of sequencing comes down these tests could be used more widely and reveal much more about both the appearance and the health risks of the new baby.
6) Microbial genomics
The ability to capture the DNA of pathogens, including bacteria, viruses, fungi, parasites and insect vectors of disease offers the best hope of tackling infectious diseases. For example China was able to deal with an outbreak of bird flu last year after sequencing the virus and making the results available to scientists around the world.
Reduced costs for DNA sequencing are likely to boost the nascent market for personal DNA testing. The leader in this market is 23andme, which looks for over 900,000 specific mutations from DNA extracted from a saliva sample. It has recently run into trouble with the FDA for making dubious claims about its ability to predict disease, and its website now promotes the service as a way of exploring your ancestry.
Sequencing is instrumental in screening plants and animals for preferred traits. Plants that can adapt to the environment and hardy animals that yield more meat and milk are being designed on the basis of genetic information.
Whether we are investigating pathogens, looking for the triggers of human disease, or re-engineering the living world the sequencing of DNA is vital. Next Generation Sequencing allows us to harvest genetic data on an unprecedented scale.

domain: medical


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African Commission on Human and Peoples' Rights. African Commission on Human and Peoples' Rights. The Lost Girls. Over the last week or so, multiple stories in the news have been asking why the media is ignoring the kidnapping of more than 200 girls (some reports say as many as 276) by Boko Haram, an extremist anti-Western group in Nigeria.
Yet there have been literally hundreds of Facebook posts, thousands of tweets, and dozens of stories in the media about what is going on. "We Were Sent to Kill You" Sitreps Detail Rwanda's Descent into Genocide 1994. Washington, DC, April 7, 2014 –The complete series of daily and weekly situation reports (sitreps) written by UN peacekeepers in Rwanda — published today by the National Security Archive for the first time in full — provides a detailed, on-the-ground perspective on the genocide in Rwanda that started twenty years ago today.
Today's posting is a collection of every single sitrep from the beginning of the United Nations Assistance Mission for Rwanda (UNAMIR) in October 1993 to the end of the genocide on July 18, 1994. The documents tell a story of the broken Rwandan political system and a peacekeeping force that, because of a lack of support from UN headquarters in New York and from the members of the UN Security Council, was not equipped to handle the rising violence. UN Peacekeeping Troops in Rwanda circa September 1994. Photo from personal collection of Prudence Bushnell. China-based corporate web behind troubled Africa resource deals.
For centuries, wave after wave of colonists and foreign investors have swept through Africa, looking for profits from the continent’s abundant reserves of oil and prized minerals.
Many instead left records of corruption and broken promises of shared wealth with Africans. It is against this backdrop that an eager conglomerate has recently been drawing attention and generating headlines throughout Africa. China-Sonangol is part of a global network of companies extracting oil in Angola, buying gold in Zimbabwe, building luxury condominiums in Singapore and developing property in Manhattan. MENA (the Middle-East & North Africa)
Map Room: Hidden Waters. InFocus » What Does the Fall of Goma Mean for Central Africa? Israel Siphons off Africa’s Nile. Egyptian and Sudanese policy failures have lead to a looming strategic threat to both countries’ most important resources – the Nile.
Israel has now signed an agreement with the South Sudanese authorities over rights to the country’s precious water source. Cable shows U.S. permission required for key Ugandan combat ops. By Stephen C. WebsterWednesday, April 11, 2012 10:54 EDT Update (below): Publisher confirms cyber attack following Raw Story report A U.S. State Department cable composed in Dec. 2009 sheds yet more light on the murky relationship between the Obama administration and the Ugandan government, pointing to an information sharing agreement that prohibits the Ugandan regime from engaging in certain combat operations against the Lord’s Resistance Army (LRA) without U.S. permission. Specifically, the cable states that Ugandan forces may not utilize U.S. intelligence to engage enemies without first consulting U.S. officials.
Niger Delta: a quiet resistance. 2nd explosion strikes near Nigeria church by Jos. LAGOS, Nigeria (AP) -- Suspected Muslim extremists kidnapped about 100 girls Tuesday from a school in northeastern Nigeria, less than a day after militants bombed a bus station and killed 75 people in the capital - a surge of violence that raised new doubts about the military's ability to contain an Islamic uprising.
With an 11-month-old state of emergency in three northeastern states failing to bring relief, the attacks are increasing calls for President Goodluck Jonathan to rethink his strategy in confronting the biggest threat to the security of Africa's most populous nation. The attacks by the Boko Haram terrorist network have killed more than 1,500 people in this year alone, compared with an estimated 3,600 dead between 2010 and 2014. In the latest attack, gunmen killed a soldier and a police officer guarding a school in Chibok on the edge of the Sambisa Forest and abducted the teenage girls after midnight, according to authorities.
M.D. Farther south, Gov. Ethiopia charges six journalists with terrorism. New York, November 11, 2011--A judge in Ethiopia's federal high court charged six journalists with terrorism on Thursday under the country's antiterrorism law, bringing the number of journalists charged under the statute since June to 10, CPJ research found.
Twenty-four people, including imprisoned dissident blogger Eskinder Nega and five other journalists critical of the government who work online and in exile, were charged, according to the court charge sheet obtained by CPJ. France, Africa: Suitcases Filled with Cash Expose the Françafrique Connection. In the wake of the Dominique Strauss Kahn scandal, a new furore is now rocking France and the upcoming 2012 French presidential campaign.
Robert Bourgi, a shady lawyer and advisor for “African affairs” has confessed [fr] to French media he acted for years as a go-between for French politicians and Francophone Africa heads of states, delivering approximatively $20 million in cash to former President Chirac, former Minister of Foreign Affairs Dominique de Villepin, and extreme-right leader Jean-Marie Le Pen, to finance past election campaigns. Screen shot of Lawyer R. Bourgi on BFM TV “Not exactly breaking news” China-based corporate web behind troubled Africa resource deals. Special Coverage on Conflict Minerals. Jump to: Overview | Current Policy | Solutions | Campaigns & Programs Your mobile phone, your computer, your portable music player, and your gaming system all fuel fighting in eastern Congo.
Take Action Now » Overview Armed groups earn hundreds of millions of dollars every year by trading conflict minerals. The Price of Precious. Conflict Minerals. ZIMBABWE: Minister Trying to Create a "Paper Tiger" Human Rights Commission. HARARE, Oct 10, 2011 (IPS) - Zimbabwe’s justice minister is frantically trying to fend off probes into allegations of human rights abuses perpetrated by President Robert Mugabe’s regime since the country’s independence in 1980. US Quietly Assumes Military Posture in Africa. UN declares famine in three more areas of Somalia - GlobalPost. NYT photographer details Somalia's famine Chaîne de bbcguests.

domain: news


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This week's edition of Critical Reception examines online reaction to Tales of Monkey Island Chapter 1: Launch of the Screaming Narwhal
, which reviews describe as "a great opportunity to explore the reemerging world of adventure gaming." The game currently earns a score of 79 out of 100
1UP.com's Justin Hayward gives the first chapter of Tales of Monkey Island a grade of A
"Telltale Games' spate of regularly updated, episodic games, like the Sam & Max
revamp and the newer Wallace & Gromit's Grand Adventures
, has brought the seemingly outdated point-and-click adventure genre from fading obscurity back to... at least the modern consciousness, if not blockbuster success," he explains. "The company's latest adventurous outing revives the classic Monkey Island
franchise with a fresh set of five episodes in Tales of Monkey Island
Hayward believes that the first title in Telltale's new episodic series will impress Monkey Island
fans. "Launch of the Screaming Narwhal
keeps the same sporadic, pun-laden humor, and spot-on voice acting of the previous point-and-click adventures, but adds in improved mouse controls and updated graphics," he says. "For long-time Monkey Island
is exactly what you've been waiting for."
includes a number of convenient features that other adventure titles lack. "The developers added options that make getting around the game's Flotsam Island setting quick and painless," Hayward notes. "When you leave town, you can automatically warp to any point of interest in the surrounding jungle that you've previously visited."
"An adjustable hint system also keeps the game fast-paced," he continues. "If you want to go through the game completely on your own, you can turn it off, but if you'd like a little guidance when you get stuck, Tales
throws in the occasional clue."
"Whether or not you've ever experienced Monkey Island
's ridiculous puzzles and eccentric characters," Hayward concludes, "this is a great opportunity to explore the reemerging world of adventure gaming."
At Giant Bomb, Ryan Davis scores Narwhal
at 4 out of 5 stars
. "Considering the actual quality of the previous Monkey Island
games, as well as the legend that people have built up in their minds during their eight-year absence, expectations are high," he notes. "Luckily, Telltale is staffed to the gills with folks who were key players in past Monkey Island
games, and they don't seem to have lost their touch with Tales
The new episode makes a good starting point for series newcomers. "This episode seems very deliberately designed to ease you back into the world of Monkey Island
," Davis assures. "Elaine and LeChuck don't figure in too heavily just yet, allowing you to get familiar with the unique way in which Guybrush buckles swash, as well as the series' goofy, anachronistic, easy-going approach to the topics of piracy and island voodoo."
Davis finds that Narwhal
lives up to the franchise's high standards for humor and puzzle complexity. "There's a good amount of funny, well-delivered dialog here," he writes, "and the story is propelled by puzzles that tend to focus on combining and using inventory items in unconventional ways, as well as the deciphering of treasure maps."
"I was really satisfied with the three or four hours it took me to get through Launch of the Narwhal
," he continues, "and the episode ends on a delicious cliffhanger that has me eager to see what happens in next month's episode."
IGN's Jason Ocampo rates Narwhal at 7.9 out of 10
, warning that the game has closer ties to its upcoming episodes than other Telltale franchises. "Previous Telltale series such as Wallace & Gromit
featured what were essentially stand-alone episodes," he explains. "You'll need to play all five Tales of Monkey Island
episodes to get the whole story. There's a risk with this, but also the promise of a greater narrative reward in the end."
"As you'd expect, Tales of Monkey Island
comes off a bit tentative," he continues, "and it feels exactly like what it is: the opening chapter in a much longer saga."
Ocampo notes that many of Narwhal
's puzzles rely on logic peculiar to the adventure genre. "Getting off the island is a process that lasts three to five hours, as there are a slew of puzzles to navigate through, many of which fall in the adventure genre's standard 'collect a bunch of things and then try using them on various objects until something clicks,'" he says. "While there's an imaginative use of a cheese wheel and a pirate's underwear, these types of puzzles are fairly standard for the genre."
The humor is similarly hit-and-miss. "While Telltale gets great marks for bringing back the original voice cast for the main characters," Ocampo praises, "the dialogue doesn't quite crackle as we remember it. That could be a result of some rust on the franchise as the writers learn to recapture the characters' voices again."
Ocampo also finds frustration with Narwhal
's cliffhanger ending. "The finale lacks epic triumph and the denouement amounts to a cliffhanger, leaving more questions than answers," he says. "Episode 1
gets high notes for bringing us back into the Monkey Island
universe, but at the same time, it looks like we'll have to wait for the rest of the episodes to roll out over the next four months or so to get all the answers."

domain: entertainment


The role of music distributors is to get music in the different stores for selling. The key role of the music distributors is the same even today but their business models have changed consistently. From the CD era [physical marketing] to Streaming trends [digital marketing], the music industry has experienced massive change. Today, you can sell your songs online without the need for record labels or as an unsigned artist.
How digital music distribution process works?
Songs are uploaded and made available to worldwide listeners. So, why do artists need music distributors? Can’t they adhere to DIY? No, music distributors are still crucial because of the following –
Distribute to digital service providers
The majority of DSPs don’t allow direct music upload, so artists have to partner with the distributor’s aggregators. It saves them the stress of handling unstandardized Metadata as well as payments. To get your music on Spotify or iTunes, you will be suggested to go with a music distributor. Spotify and Apple need to ensure that the Metadata suits their platform needs.
MusicDigi allows selling your music on iTunes, Spotify, Amazon, and 150+ streaming platforms. All these DSPs most probably have unique Metadata requirements. So, for an artist, it is not possible to manually handle online music distribution. You can sell your music on iTunes, Spotify, Amazon, and 150+ streaming platforms with a small fee of $39.99 per year. Gramhir is one of the best Instagram analyzer and viewer. Gramhir’s algorithm makes it conceivable for you to examine your own or another person’s Instagram account stats.
The traditional way of delivering a box of CDs and getting paid by the music retailer has been replaced with a flexible payout system. The way music is consumed and purchased is inseparable in this streaming world. The rightful music owner earns the moment users press play.
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Even if you decided to sell your music on Amazon directly and they paid the royalties directly, their administrative cost would be high. The music owners would not be excited at getting royalty checks from different digital music stores. The aggregators serve as a platform for collecting royalties from different DSPs.
Aggregators or open distribution platforms are uploading myriads of music on digital music stores and streaming services. So, to get your music on TikTok goes viral ensure to create a track that hits the masses emotionally.
Using a flat-fee distribution deal means you have to consider album promotion seriously. The distribution platform will offer a default cover art but make sure to have one created that suits your music album theme. First, get your songs on YouTube Music and create hype. The song video has to be for a few minutes. It will create excitement amongst music listeners before the release date.
Promotion is essential to gain fame and even fortune. If you don’t promote, no one will know that your music resides on several digital music stores. Schedule live online performances on social channels, book concerts, play your music at the local coffee shop, post short clips of your songs on Instagram, create a reel, etc.
Just getting your songs on iTunes, Spotify, and 100 stores is not enough. You need to make efforts in the promotion to grab attention and build a fan base.


- Investigators will be going through Ameriwood Industries in Dowagiac today to try to determine what caused an explosion.
- The partial shutdown of the federal government has come to an end after 35 days.
- Now that a deal has been reached to re-open the federal government for three weeks, human services agencies throughout the country are breathing a sigh of relief.
- Holtec International says it’s disputing objections from an environmental group over a proposed nuclear waste dump in New Mexico.
- Congressman Fred Upton has re-introduced legislation designed to help fund FIRST Robotics teams around the country.
- Governor Gretchen Whitmer is expected to endorse a sales tax shift at the pump to put all of that money into the roads.
- It’s another winter day in Michigan with up to a foot of snow expected in some areas.
- Tax filing season officially begins today.
- Here’s a reminder to change your passwords and check your anti-virus software, on what’s being call Data Privacy Day.
- Not even an Academy Award winning actor could put a crack in “Glass” at the movies this past weekend.
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Pleng Ruk Rim Fang Kong Lakorn
Category: Movies, TV, Celebrities
I just got done watching the Lao Lakorn (soap opera) starring Weir and Alexandra. I can definitely confess that I was obsessed with that love story! Thank God for Darly at Saolao.net for posting the episodes! I was like a druggie who was hooked! The Lakorn was so good because of the chemistry between the two lead actors. Also the songs were awesome. In fact I liked the songs so much I ordered the CD from eThaiCD.com. If you have nothing better do or needed to be reminded of what a good Lao love story is then you need to watch it. Saolao.net has all the episodes. I love the story because it shows how traditional Lao courtship is like: sweet and tender. The Lakorn reminded me of my teenage years growing up as a young woman in the Lao community. It brought back memories of how the young Lao men showed how they liked you through sweet compliments and songs. The guys took the time to make you feel special and pretty through with their teasing. I don’t think dating is like that anymore. I think we rush through the process of getting to know someone because we get toobusy or just plain lazy to put too much effort into winning someone’s heart.

domain: artistic


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FOR IMMEDIATE RELEASE
JM6 Ranch Welcomes New FSA Approved Stallion Diamanté to Expand Equine Excellence!
Odessa, Tx, October 9, 2023 (USANews.com) - JM6 Ranch, a leading equine facility known for its commitment to breeding and training exceptional friesian horses, is thrilled to announce the arrival of their new approved FSA stallion. This addition marks a significant milestone in the ranch's ongoing efforts to expand equine excellence and further enhance their breeding program.
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JM6 Ranch has built a reputation for its commitment to excellence, and the addition of this new FSA stallion further solidifies their position as a leading equine facility. With state-of-the-art facilities, experienced trainers, and a dedication to the well-being and development of their horses, JM6 Ranch continues to attract discerning horse enthusiasts from around the world.
To celebrate the arrival of the new FSA stallion, JM6 Ranch will be hosting an exclusive unveiling event in the coming months. This event will provide an opportunity for horse enthusiasts, breeders, and industry professionals to witness firsthand the exceptional qualities of this stallion and learn more about the ranch's breeding program.
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About JM6 Ranch:
JM6 Ranch is a renowned equine facility dedicated to breeding and training exceptional horses. With a focus on performance and temperament, JM6 Ranch has established a reputation for producing top-quality horses that excel in various disciplines. Located in Odessa, Texas , JM6 Ranch offers state-of-the-art facilities, experienced trainers, and a commitment to equine excellence.


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What film studio has a 100% track record? Seriously, Pixar does it again and again and again, and they find a new way to delight their audiences each and every time. With the exception of a few minor complaints, Up is easily another perfect movie.
Pixar are always expanding their storytelling horizons. As heartwarming as Wall•E and Nemo were, there’s something new about how the story of Up is told. The first – largely dialogueless – fifteen minutes of the film are among the most poignant I’ve ever seen in a film, let alone an animated one, and convey a sort of humanity and depth that is an incredible achievement. That segment could easily have been a short film on its own merits.
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The movie stumbles a bit. I don’t want to give anything away, but while part of its charm is how unafraid it is to go over the top, sometimes it does go a bit far. And I thought that the climactic part of the film fell apart somewhat halfway through.
This is a pretty short review, because I don’t want to overanalyze a movie that’s simply pure fun. One final thing I will note that whereas from a technical perspective Wall•E explored and mastered cinematography, Up explores new horizons in lighting, to fantastic results.
Go see it. Go see it in 3D; they do it incredibly naturally and it’s a beautiful subtle enhancement to the film. Too bad it won’t be in 3D on Blu-Ray.


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domain: law


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Sleight (2017) HD
|Writer||:||J.D. Dillard, Alex Theurer.|
|Release||:||April 28, 2017|
|Country||:||United States of America.|
|Production Company||:||High Top Releasing, Diablo Entertainment, BH Tilt.|
|Genre||:||Drama, Thriller, Action, Science Fiction.|
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Vidalia onion tart
Uncooked vidalia onion(s)
1 large, (about 3/4 pound), thinly sliced
4 medium, kalamata, pitted and chopped
1 tsp, fresh, chopped
¼ tsp, freshly ground
2 sheet(s), (12 x 17-inch) sheets, at room temperature
2 Tbsp, shredded, Jarlsberg variety, shredded
- Heat the oil in a medium nonstick skillet over medium-high heat. Add the onion, water, and salt; bring to a boil. Reduce the heat and simmer, covered, stirring occasionally, until the onion is very soft, about 20 minutes. Remove from the heat and stir in the olives, thyme, and pepper; cool slightly.
- Preheat the oven to 400°F.
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- Spread the onion mixture evenly over the phyllo. Bake the tart until the edges are golden brown, about 20 minutes. Sprinkle the tart with the cheese and bake until the cheese melts, about 5 minutes longer. Yields 1/2 tart per serving.

domain: food


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In the days following the release of the Ted Wells report there were questions what the Dolphins would do with center Mike Pouncey.
Would they trade Pouncey because he was implicated, along with Richie Incognito and John Jerry, as the alleged tormentors of Jonathan Martin?
Would they cut Pouncey?
Would they bring Pouncey back regardless of possible NFL sanctions (read suspension) for his part in the scandal?
Well, we have the answer, beyond the idea that Pouncey is not on the trade block, which I reported Feb. 17 wasn't an immediate issue:
The Dolphins are committed to Mike Pouncey. Dolphins general manager Dennis Hickey told WMEN's Orlando Alzugaray Thursday that he has spoken with Pouncey in the past month and "is excited about the future."
And according to a club source, both Hickey and Dolphins executive vice president of football administration Dawn Aponte met with Pouncey's agent Joel Segal while at the Indianapolis Combine last week and shared a similar sentiment from the club.
That doesn't mean all is settled.
Right now, Pouncey is scheduled to hit the final year (2014) of his fully guaranteed $9.259 million rookie deal. That deal will pay Pouncey $1.63 million in 2014. But the Dolphins are able to pick up an option year on Pouncey in May that would tie him to the team for a fifth year through 2015.
The Dolphins fully intend to pick up that option, according to a club source.
But here's the thing: Pouncey, perhaps the second-best player on the Dolphins offense and the only player left from the offensive line of the past two seasons, doesn't necessarily want to play under his rookie deal for a fifth year.
Pouncey will want an extension.
So what will happen at that point?
Two options: The Dolphins, not needing more holes on the offensive line, will have to entertain the extension idea (very likely). Or the Dolphins might consider trading Pouncey then (not very likely, but it's an option that cannot be dismissed).
All that isn't an issue now but the matter will have to be addressed before the 2014 regular-season begins.
The key short-term issue is waiting on NFL commissioner Roger Goodell to see if he hands down any disciplinary action against Pouncey -- not to mention Jerry and Incognito -- to determine if the only remaining starting offensive lineman on the Dolphins roster will have to serve a suspension.
On that issue, Pouncey has heard unofficially from the NFL Players Association that he is not likely to get suspended, according to a source. But, of course, the NFLPA doesn't determine whether there is or isn't a suspension from the league.
So that remains the most important question on the table. Until it isn't.


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221 Whitney Avenue
8 articles with Yale University
Collaboration aims to accelerate the development and translation of Yale's research and innovation projects to a decision point.
Politicians might deny climate change, but disease-carrying insects and their pathogens aren’t—they’re exploiting it.
BlackThorn Therapeutics Announces Exclusive Licensing Agreement and Extension of Key Collaboration With Yale University
First Publication Emerges from Company’s Multi-year Research Collaboration with Yale’s Division of Neurocognition, Neurocomputation, and Neurogenetics
July 13 Research Roundup: Gene Therapy for Cholesterol, Beta-Thalassemia, and Kidney Disease, and...
7/13/2018There are plenty of great scientific research stories out this week. Here’s a look at just a few of them from gene therapy for cholesterol to kidney disease and more.
Educational institutions, even at the high school level, are creating specialized biotechnology training programs to satisfy the growth they see within the biotech industry.
A research group at Yale University and from Hanyang University, South Korea, developed a new RNA therapy for West Nile Virus. The findings, which were studied in mice, was published in Cell Host & Microbe.
Enigma Biomedical Group and Yale Sign Memorandum of Understanding to License Novel Investigational Synaptic Density Imaging Biomarker Technology
Understanding to License Novel Investigational Synaptic Density Imaging Biomarker Technology
Patrys Limited is pleased to announce further pre-clinical data for its drug candidate PATDX1-NP.


text:
Supergroup shrugs off High Street fears with jump in first-quarter sales
Supergroup wowed the market with a 60pc jump in first-quarter sales as it shrugged off fears over the consumer slowdown.
The High Street chain, which has seen its shares more than double since its March float, owns the Superdry fashion brand popular with celebrities such as High School Musical star Zac Efron and David Beckham.
Setting a trend: Zac Efron and David Beckham are big fans of the Superdry brand
The firm, which has 47 stand-alone outlets and 56 stores within stores, said total group sales for the three months to August 1 rose to £32.8m from £20.5m.
Some investors took profits sending the shares down 42p to 1107p.
Chief executive Julian Dunkerton was upbeat on future trading, saying his young customers were not feeling the ill effects of the downturn.
He also sought to explain the stock’s strong performance in the wake of a dismal post-float performance from rivals saying: ‘The difference is we are very profitable, we are spitting out cash, and growing at a fast rate.
‘I don’t think many other businesses tick all three boxes.’
Most watched Money videos
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domain: finance


text:
China’s rise as a global superpower has resulted in no shortage of ambition. The country has a rapidly evolving space program, wants to construct its own version of the Panama Canal and is now seriously exploring a railway route from Beijing to the United States.
The route would see passengers travel under the Bering Strait to Alaska, Canada and eventually America.
The 8,000 mile journey would require two undersea tunnels. One would run from Russia to the Big Diomede Island, and one from Little Diomede Island to Alaska. The three miles that separate the two islands would either be crossed by a bridge or tunnel.
The Diomede Islands are the only land masses between Russia and Alaska.
While the idea of connecting Russia to Alaska has been around for over 100 years, advances in technology and China’s huge appetite for mega-scale infrastructure projects mean such an idea is no longer the realm of science fiction.
Leading the effort complete the ambitious project is Wang Meng-shu, one of China’s top railway construction engineers and a scholar with the Chinese Academy of Engineering specializing in tunnel and underground projects.
According to Chinese website Sina, Meng-shu has developed the plans for a route from northeast China through the Bering Strait. The plan, which he has been working on for nearly a decade, would have over 140 miles of tunnels, though constructed in at least two segments.
While the proposed project is breathtakingly ambitious it is also technically feasible, according to analysts who follow the Chinese infrastructure sector.
The 8,000 mile journey would take two days of travel at about yet as the international date line splits the islands it would only ‘take’ one day.
While it is easy to dismiss the idea its important to remember that China has a number of ambitions train projects in the works, including a massive rail network to connect it with Russia and eventually the middle east.
It is also experimenting with a Hyperloop-style enclosed system which could see speeds of 1,800 miles per hour.


Used Fender Vintage Reissue ’63 Reverb Unit
The ’63 Fender Reverb is a replica of the original 1963 Fender tube reverb standalone unit. Features a solid steel welded chassis and all-tube circuitry. Includes dwell, mix, and tune control. Fender ’63 Reverb is brown with tan grille cloth.
- 6V6 Groove Tube
- 12AX7 preamp tube
- 12AT7 tube
- Dwell, Mix, Tone controls
- On/Off footswitch included
- 10-1/2″H x 18-7/8″W x 7-1/2″D
- 13 lbs.


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Tips For New Cannabis Home Growers
Learning to grow cannabis can be an overwhelming battle with information overload. There are so many styles of growing, each with its own sets of equipment and supplies. It can be very difficult to know where to start.
Today, we want to go over our favorite tips for new cannabis growers. Hopefully, these pieces of advice will help you on your cannabis-growing adventure. If we missed any of your favorite tips, let us know on social media!
Do Your Research
While there is a ton of information out there about growing cannabis, there are a few decisions that need to be made before you get started. Before planting your first seed, figure out what you are going to do for lighting, growth medium, seeds, and supplies. There are many different methods for growing cannabis, and basic research will help you begin to develop a growing strategy.
Understand Your Grow Space
During its life cycle, cannabis plants need different levels of temperature and humidity. If you are growing cannabis outdoors, make sure that you understand how weather and the elements can affect your plants. If you are growing indoors, learn about how air and heat flow through your grow space. Consider options like humidifiers, dehumidifiers, and heaters that can help you better control your indoor climate.
I cannot stress this enough. Do not burn your house down by overloading your electricity with lights and fans. Understand the electrical capabilities of your grow space and plan accordingly. If you are not comfortable with home electricity, please call a professional to help you.
Learn About The Types Of Seeds
When it comes to growing cannabis, there are three main types of seeds. Regular seeds contain male and female plants. The male plants need to be discarded, or grown separately for pollen collection. Feminized seeds are, as the name suggests, female. Autoflower seeds do not get as big as regular seeds and flower automatically without a strict light schedule. Figure out what seeds are going to work best for you and your grow area.
Purchase Quality Seeds
Not all cannabis seeds are made the same. When you are first starting out, you should grab some seeds that come from reputable companies. Seeds containing better genetics will ultimately be easier to grow. Don’t get me wrong, you can successfully grow a seed found in your stash. However, this may add a level of difficulty making your first grow that much harder.
There is way more information about growing cannabis than can be learned before your first grow. Also, a lot of these concepts are reinforced through hands-on practice. Keep learning as you go and do your best to improve the quality and yield of each harvest.
Don’t Overdo It
It can be really tempting to get a giant grow space and start-up twenty plants. When you are first starting, you really want to focus on each plant to learn the nuances of growing cannabis. For beginners, we recommend starting one or two plants for your first few grows. Also, when you start growing cannabis, you may realize that this is not the craft for you. You don’t have to spend thousands of dollars on gear to get started, especially if you decide to stop growing.
Join A Community
The internet contains plenty of different growing communities filled with people who will help you out. Having mentors to help guide you through the vast knowledge of cannabis cultivation will help you learn and grow your skills faster. There are also plenty of YouTubers, bloggers, and podcasters making content to help you through your growing journey.
What Are Your Favorite Tips For New Cannabis Growers?
We hope you enjoyed our list of tips for new cannabis growers. Did we miss a great piece of advice? Let us know on social media!

domain: agronomy


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Good morning everyone! Today’s Sketch N Scrap card is designed by the verly talented Heather Hall:
Just check out the possibilities of this one!
And here is my version of it: 55 more words
1 week, 1 day ago
Just checking in quickly to share my take in Cupcake Inspirations Challenge # 371, Shine Bright.
I used a diamond diecut from Ellen Hutson… 99 more words
1 week, 3 days ago
I have been playing with simple watercoloring for this stamped imaged from Some Odd Girl.
I have a very small collection of distress ink pads and I used them to do the watercoloring. 139 more words
2 weeks, 1 day ago
I’m joining in this week’s card sketch at Match the Sketch # 136. Just perfect to use some of my patterned papers.
I used the panda stamp from… 49 more words
3 weeks ago
My Little Craft Blog
Welcome to Die Cuttin’ Divas’ August sketch! Again, I’m using leftovers. I’m involved in a scrapbook/cookbook page swap and I cut out way too many little… 199 more words
3 weeks, 5 days ago
I had an order for a birthday card for a 60ish lady that loves to play golf. She also like primary/bold colors. While searching for images and inspiration I saw a card that used the Wrap it Up cricut cartridge. 166 more words
It’s time for another great card sketch (along with a single and double page sketch) over at Stick It Down. This month’s featured card designer is me! 63 more words

domain: hobby


Clintonville names Beggs as new police chief
CLINTONVILLE - James Beggs, the city's police captain for the past 20 years, will take over as police chief on April 8.
Beggs, 62, will succeed Terry Lorge, who will retire.
City Administrator Charles Kell said Beggs’ starting salary as chief hasn't been determined but will be between $67,000 and $80,000. Beggs has been employed by the police department since 1975.
Lorge endorsed Beggs as his successor. The duo served as acting co-chiefs in 1995 and 1996 before Lorge was appointed chief and Beggs was appointed captain.
Beggs said the public shouldn’t expect any immediate or drastic changes with the change in leadership.
"Terry and I have been acting as a team for the last 20 years running this place,” he said. “We have a very smooth-operating and efficient department right now."
The Clintonville Police Department employs 11 full-time officers.
Duke Behnke: 920-993-7176, or firstname.lastname@example.org; on Twitter @DukeBehnke


Buoyed by the party’s spectacular showing in the Loka Sabha elections, several office-bearers of Maharashtra BJP today said the party must not play second fiddle to alliance partner Shiv Sena in the Assembly elections which are due later this year.
State BJP chief Devendra Fadanvis told the party workers at a meeting here that grievances regarding the Shiv Sena would be addressed at an appropriate forum.
“Shiv Sena has been our friend in good times as well as bad times. Just because our party has done well in the Lok Sabha elections, it would not be correct to call for breaking of the alliance,” he said.
He was responding to speeches by some leaders who said that Sena had not allowed BJP to grow in the state in the last 25 years.
“Shiv Sena (traditionally) contests 174 seats and BJP only 114 (in the Assembly polls). The difference is too big and our party should get an equal share,” senior BJP leader Madhu Chavan said.
Some speakers wanted the party to end the alliance. “Don’t underestimate us. The party leadership should trust the workers and contest all the 288 seats and we will create history,” a BJP leader said.
Another leader said while BJP treated Sena as an elder brother, the sentiment was not reciprocated.
Chavan said Shiv Sena tried to make “a bonsai” of BJP, and this must not be tolerated. Another office-bearer said the “business of partnership” should be on equal terms.
Fadnavis, while responding, said the party had taken note of the genuine sentiments of the workers.


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Latest Home Video Reviews
Ghosts of Girlfriends Past (2009)
The movie equivalent of a fling that you won't entirely regret but won't ever want to see again.
Year One (2009)
There’s no shortage of anatomical jokes, scatological jokes, and fart jokes, toilet humor being the last refuge of a spent comedy writer.
Terminator: The Sarah Connor Chronicles - The Complete Second Season (2008)
Every week...an action-packed chase story, a
-styled slice-of-life-on-the-run, a thoughtful short story ruminating on a science-fiction concept...a tragedy-tinged psychodrama about one's pre-written role in humanity's bleak fate...
Snow White and the Seven Dwarfs (1937)
One of the most important films in the history of popular cinema, and film fans must never forget the incredible achievement it was in 1937.
Observe and Report (2009)
With admirably funkiness and bold flavor, Hill has made the anti-
...but at a time when we've seen seven mass shootings in a month, do we really need the comedy version of
The Wizard of Oz (1939)
It's more than a movie; it's an American rite of passage.
My Name Is Earl: Season Four - The Final Season (2008)
A single-camera sitcom about idiots living in 'flyover' country...the Coen Brothers film
is a clear—and acknowledged—inspiration .
Easy Virtue (2009)
A period piece that may play well with those who hate period pieces.
Wallace & Gromit: The Complete Collection (2009)
The adventures that happily disturb the slippers-and-newspaper routine emerge as surprising crosses of science-fiction comedy and the thrills and spills of Hitchcock.
Away We Go (2009)
Its dull colors and folk-rock soundtrack...attempt to achieve the oft-chased feel of '70s cinema--in this case, Hal Ashby or Mike Nichols. It's a game try, but the transparently schematic result too often gets under the skin in the wrong way.
Pierrot le fou (1965)
Theirs is, in their own words, 'A story,' 'All mixed up,' and their self-construction mimics that of their true Creator, the ever-experimental auteur Jean-Luc Godard.
Fringe: The Complete First Season (2009)
Abrams and co-creators Alex Kurtzman & Roberto Orci...chiefly credit the work of David Cronenberg for sending them into their own 'Videodrome' playground of body-threatening, science-gone-wrong invasiveness.
The Complete Monterey Pop Festival (1968)
Looking back on a time when music mattered, it's all good—at least as seen through the lens of documentary filmmaker D.A. Pennebaker...
Shaun of the Dead (2004)
Impeccable performances...crack timing...Horror plaudits aside,
Shaun of the Dead
is out in front as the funniest comedy of the year.
Hot Fuzz (2007)
Endearingly overstuffed...curiously high-strung...[but has] a pleasing sense of the absurd...
Van Helsing (2004)
A "Sommers" movie..."roller-coaster ride"...[that] rattles and swoops and thunders so incessantly that no one can much care by the time it reaches its supposed big finish.
A balance of colorful visual and aural poetry, elegant plot structure, and battles marked by a swift graphic intensity and epic scope.
Star Trek: The Original Series - Season 2 (1967)
A phenomenon the likes of which television has seen no equal...
The Girl Next Door (2004)
A seriously guilty pleasure aimed squarely at teen boys and sexual Peter Pans.
High Crimes (2002)
Despite my aversion to derivative, lazy, and improbable thrillers, I'd be lying if I said
had no pulp entertainment value.
CSI: Crime Scene Investigation - The Ninth Season (2009)
Mind-bogglingly well-produced, each hour the equivalent of a mini-movie.
Supernatural: The Complete Fourth Season (2009)
Say what you will about the highly entertaining
, but you cannot deny it traffics in the highest stakes on television.
The Office: Season Five (2009)
has the funniest ensemble of any sitcom on the air...
Lie to Me: Season One (2009)
In casting the great Tim Roth as psychologist Dr. Cal Lightman,
Lie to Me
won the added value of a weekly master class in acting.
Heroes: Season 3 (2009)
still has some way to go in restoring the cohesion of its initial run, but Fuller has helped the show to prove it's capable of hitting a stride and mining fresh stories that deepen the mythology...
Montiel and his collaborators can pat themselves on the back for elevating empty material just a bit, but this is disposable cinema, designed to hit and run after an opening weekend.
showcases a lovely performance by Soto, a match for the modest, low-key filmmaking style of Boden and Fleck...
The film's greatest pleasure is in the snappy dialogue Gilroy crafts for the capable duo of Roberts and Owen...
Sons of Anarchy: Season One (2008)
Despite having something of the flavor of TV's most testosterone-laden shows,
Sons of Anarchy
is its own distinctive beast and another worthy entry in the stakes of addictive serialized TV.
State of Play (2009)
Macdonald shifts the emphasis to highlight a moment when declining readership and corporate bottom lines threaten the tradition of print journalism.
How to Lose a Guy in 10 Days (2003)
A modest but bubbly comedy of manners.
Sunshine Cleaning (2009)
The sort of movie you root for, hoping it’ll break through to be something special. It never quite does, but it still has the not-insignificant value of two fine actresses cast as sisters.
Smallville: The Complete Eighth Season (2009)
has morphed into something awfully close to
The New Adventures of Lois and Clark
, it continues to be an entertaining and occasionally poignant pastime for
The heart of
lies in the emotional microcosm of the amusement park, a place that delivers its share of laughs and lust but turns out to be not all fun and games.
Dexter: The Third Season (2009)
More diabolical than ever.
Cutthroat Island (1995)
Hey, are you looking for an exciting movie about pirates of the, well, um, Caribbean?
The Ninth Gate (1999)
Sorely underrated...wisely counter-cultural to Hollywood's idea of what a supernatural thriller should be.
Utterly unconventional and strikingly unique; it begs not to be watched in the same manner as a conventional narrative film. Like a great painting, it is meant to be savored, pored over, observed from different angles and revisited in time.
Hannah Montana: The Movie (2009)
The way this movie ends is so wrong that it doesn't deserve a pass as frothy entertainment. Why? Because it's actively sending a bad message to kids.
The Last Starfighter (1984)
Charmingly hokey...takes the suburban-working-class-folks-meet-space-aliens paradigm of early Spielberg and marries it to Lucas'
All site content © 2000-2017 Peter Canavese.
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An appeal has been issued to trace the whereabouts of a missing 14-year-old from Cavan.
Khadijah Kuhnel, a Pakistani national, went missing from the Rocklands area, Co. Cavan on Thursday, January 16.
She was last seen in the Jervis Street area of Dublin city centre on the same date.
She is described as being 5'6" in height, with brown eyes, black hair and a slim build.
Gardai have said they are concerned for her and are appealing to anyone who may have information on her whereabouts.
When last seen Khadijah was wearing green leggings and a green jumper.
A garda spokesperson said: "Gardaí and Khadijah’s family are concerned for her and are asking anyone who may know where Khadijah is or may have seen her to contact Cavan Garda Station on 049 436 8800, the Garda Confidential Line on 1800 666 111 or any Garda station"
We'll be bringing you the very latest updates, pictures and video on this breaking news story.
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Feature Article by Dai Williams
Just before we start…
Geoff here – I just wanted to drop in a couple of photos of Dai’s very presentable T-18 Soviet Light Tank right up front – nice job Dai!
Over to you Dai…
The subject of this build is the Hobby Boss Soviet Light Tank (Model 1927) kit.
The T18 was one of the first Russian designed tanks, appearing in 1927. The vehicle like its predecessor the T16 was based on the French Renault FT, but used a different suspension. Tests with the vehicle were not particularly successful with its performance over rough ground and its trench crossing ability leaving much to be desired. Despite this, a production order was placed and further trials were carried out in order to improve the trench crossing issues. These led to a ‘tail’ being added to the front of the vehicle similar to that already carried on the rear. Though this did in fact increase the width of trenches that could be crossed, it interfered with the driver’s visibility and so the idea was abandoned.
The chassis was further developed to produce the SU18 assault gun. At the time of writing I believe that a kit of this variant may be due from Hobby Boss in the near future.
The HobbyBoss kit
The box art depicts a vehicle carrying a light machine gun next to the main armament in the turret. However, the kit is slightly different with what appear to be two machine guns in this location. A quick search around the internet revealed photos of the T18 with several armament configurations in several types of turret including the one that could be built from the parts provided in the kit. However, those wishing to build the particular variant shown on the box top will have some extra work to do.
The kit has 120 parts spread over four sprues with three separate parts for the upper and lower hull and the turret. These are all cleanly moulded with no flash and only a few mould release pin marks to clean up. The layout of the sprue holding the turret parts suggests that other variants may be released in the future. In addition to these parts there are two sprues of separate track links with 59 parts on each. Each track link has only two attachment points so these were quickly and easily separated from the sprue and cleaned up.
There is a small etched brass fret with ten parts for which there are no plastic alternatives.
The instructions are in the usual Hobby Boss style and are clear with easily followed diagrams.
There is only one colour scheme on offer which is an overall dark green. I must admit that I am a little confused regarding the actual colour used on these vehicles. A search around the various modelling discussion groups on the internet seemed to suggest two options. Some stated that in the interwar period Russian armour would have been painted in a green colour known as 3B and that this differed from the wartime green known as 4BO in that it had more of an olive hue. However, I have seen others that stated that the interwar and wartime colours were in fact the same and that only the colour designation actually changed from 3B to 4BO. Feeling that I wasn’t going to get a definitive answer any time soon, being aware that the world might end at any moment and knowing that the effects of sun, rain, dirt and general wear and tear would change the colour anyway, I decided to paint my model in much the same way as a Soviet wartime vehicle and have done with it.


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Historical Stock Chart
1 Year : From May 2012 to May 2013
Experian PLC (EXPN.LN), a global information services company, said Monday that it has acquired Conversen Inc., a provider of multi-channel campaign management software in North America, for an undisclosed sum, adding that the acquisition will be funded from Experian's existing cash resources.
-At Dec. 31, 2011, Conversen reported gross assets of $1 million.
-Experian shares at 0803 GMT up 3 pence, or 0.3%, at 872.5 pence, valuing the company at GBP8.74 billion.
-By Razak Musah Baba, Dow Jones Newswires; 44-20-7842-9275; email@example.com

domain: economics


text:
updated 04:31 pm EDT, Tue May 22, 2012
Bluetooth 4 added to MetaWatch dev kit for iPhone 4s connectivity
Meta Watch has officially released a new smartwatch development system with Bluetooth 4.0, capable of integrating with both iOS and Android devices. A previous beta was limited to Android only. In iOS, an app pushes basic notifications to the watch for things like calls and messages. Developers have access to an API, though, which will let their own apps push virtually any information.
The AU2001 (white) and AU2004 (black) both have 96x96 LCD reflective screens and are 3 ATM water resistant. Compatible with the iPhone 4S, third-generation iPad and most Android 2.3+ phones, each dev unit also sports a 3-axis accelerometer, vibration, and ambient light-sensing functions.
Meta Watch was bought out from Fossil -- its original creators -- by an investment group in September last year. Since then, though, the concept has gained competition in the form of the Pebble smartwatch project on Kickstarter.
Both development watches are on the MetaWatch website and the Ti eStore for $200.