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Saturday, December 17, 2011
When you meet a lady, don’t kiss her mouth, but her eyes, because there is love on her eyes specifically designed only for you!
When you meet a beautiful lady, don’t look at her big breast, but her forehead because what makes her alive and charming is the brain behind it.
When you are captured by a lady’s physical charm, think first not about her physical attraction, but about what exists inside her abdomen.
When you are not conquered and intoxicated by the physical beauty of a lady, you can freely enjoy all of the charms she has for you.
The beauty of a lady’s body and face is not to be covered by a piece of cloth, but to be enjoyed thankfully as the gift of nature for all.
Enjoy thankfully the beauty of a lady’s body and face as you can enjoy a beautiful painting of a famous painter of the world.
A gorgeous lady and a beautiful painting are not mutually exclusive.
Mystics past and present imagine the beauty of their God as the beauty of a lady’s body, face and mouth which are worth enjoying indeed.
Even the intense sexual intercourse between a man and a lady in the night is imagined by mystics as the unity between a believer and her God.
You cannot dismiss sexual imageries and symbolism when you wish to articulate your intense relationship with your God.
God is essentially sexual, and sex is essentially godly.
You, men, therefore, should not blame sex in defense of your anti-sexual patriarchal religion.
You, men, therefore, should not use your male God to silence the voice of enlightened and free women of the world.
Without sex, there is no god of whatsoever form and essence.
Sex is not evil; but the religious man who thinks the beauty of a lady’s body as evil and therefore tries to regulate it, is evil.
Keep calm, please!
by Ioanes Rakhmat
December 16, 2011
The symbol of feminine Venusian sex power, force and spirit which has
the features of infinity, unity, wholeness, compassion, beauty, birth, growth,
fragrance and brightness. The circle represents both Planet Venus, perfection,
infinity, fertility, and feminine power.
Sex is power; the man who cannot appreciate the beauty of sexual parts of a lady’s body therefore knows not about the power a woman has.
A woman who knows the beauty and attraction of the sexual parts of her body is a woman of power who can’t be conquered by a man's religion.
A religion that hates a woman’s beauty and sexual attraction is a religion of the male being and therefore is replete with jealousy.
Give chances to women of the world to construct religions if you wish to live in a world in which compassion and the motherhood prevail.
If your God is a true God, it must be an androgynous God who has the motherhood as well as the fatherhood sides of its personality.
The time has come to bury the male God once for all, and to resurrect the androgynous God who long since has been killed by the male culture.
Judaism, Christianity and Islam are the religions given birth to by the male culture of antiquity, and therefore contain evil misogyny.
So, I repeat, give chances to women of the world to construct religions if you wish to live in a world in which compassion and the motherhood prevail.
Women, make your brains as attractive and charming as your beautiful breasts!
Women, conquer man and his patriarchal religion by your natural beauty and brilliant brains!


Barcelona midfielder Cesc Fabregas has challenged former side Arsenal to maintain their consistency ahead of what could be a crucial Premier League run-in.
The table-topping Gunners visit Liverpool on Saturday lunchtime, and a win would seem them extend their lead over Chelsea and Manchester City to five points.
Fabregas, who played for Arsenal from 2003-2011, said he would be delighted to see his old team win the title, but admitted it is difficult to keep a run going as the season reaches the business end.
Speaking to the Daily Mail, Fabregas said: "It would be amazing [if they won the league], they need to be very consistent between now and the end of the season.
"I am very happy how they are playing, they have a strong squad, they are top of the league. I cannot wait to see if they can lift the trophy finally."
"In one season it’s impossible to win every single game, you will always lose," he added. "Whether it’s the League Cup, FA Cup, Champions League, there’s so many games. The Premier League is a very tough league. Anyone can beat you. It was a very entertaining game."
The trip to Anfield is the beginning of a difficult couple of months for Arsene Wenger's side.
Before the end of March, the north London side will have played Liverpool, Manchester United, Tottenham, Chelsea and Manchester City, as well as squaring off with Bayern Munich in the Champions League.


text:
Parkinson gets his crown
BERNIE BAKER / SPECIAL TO THE STAR-ADVERTISER
1 of 1
Joel Parkinson won the Reef Hawaiian Pro men's surfing contest yesterday.
Photos: 2014 Endless Summer Photo Contest entries
Photos: Okinawan Festival, August 31
Photos: Volleyball: UH vs. San Diego State, August 31
More Photo Galleries »

domain: hobby


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- 1 apple, cut into chunks
- 1 pear, cut into chunks
- 1 peach, cut into chunks
- 1 cup of grapes
- 1/2 cup vanilla yogurt
- 1/2 cup Greek yogurt
- 1/4 cup Craisins® Dried Cranberries
- dash of cinnamon
- Cut the apple, pear, and peach into chunks.
- Combine these with the grapes.
- Pour the vanilla yogurt over the fruit and mix well.
- Top the entire fruit salad with a big dollop of Greek yogurt and add a dash of cinnamon.
- Sprinkle with Craisins® Dried Cranberries.
- Serve immediately.

domain: food


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Sunday, October 26, 2008
My kids are very curious about the world around us. We would like to see how many postcards we can get from people with some facts about where they are from. Can you please mail my kids some postcards and and spread the word. Let's see how many we can get. I will keep you posted and let you know when I receive them. I will keep this going for the rest of the year and try to spread the word around. Please help me with this. You will mail to Pravan and Priyasha Landry 8140 Willow Ranch Trail Reno NV 89523 USA Thank you for helping. Pravan will be taking these into the classroom as he receives them and will share with his class a little about the place that it came from and also point it out on the map. I will have a map in his room and will put thumb tacks on the place that we received one from. I really appreciate your help.

domain: geography


- Grade: Middle School
- Discipline: Earth & Space Science
Construct a scientific explanation based on evidence for how the uneven distributions of Earth’s mineral, energy and groundwater resources are the result of past and current geoscience processes.
Bison, Tribes, and Symbols Classroom Visit
Learn about the various uses of Bison and their importance to local tribes through hands-on activities. Cross-cutting Concept: Native American tribes have had connections to the Tetons for over 11,000 years and still do today. Tribes are diverse and every tribe has its own traditions, culture, languages, symbols, beliefs, and relationships to the environment. Bison […]Learn More


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Are a PRODUCER, SONGWRITER, or an ARTIST who needs professional guitar parts that will ENHANCE and COMPLIMENT your music or tracks? I am super passionate about recording and producing music. I have worked with clients & artists from all over the world, gaining their trust, respect, and delivering guitar parts that totally compliment and support … Read More
Here’s a track written by Steve and myself that we have had pitched to a number of artists in the USA. It’s a good example of how we often work with friends and session singers in Nashville to produce the desired end result.

domain: artistic


The Santa Monica City Council has denied an appeal that would have halted the construction of a 19-unit condominium project at 1433-1437 14th St., the former home of Crescent Bay Convalescent Hospital.
The Planning Commission approved development permits for the project in October after the applicant — 1433-1437 14th Street LLC — modified the project design and made it more compatible with the immediate neighborhood, as requested by the Planning Commission in June.
The project design has undergone multiple revisions “in response to staff concerns regarding mass and height relative to adjacent properties, apparent massing from the street, lack of openness and pedestrian orientation,” said Eileen Fogarty, the city’s director of planning and community development.
A neighbor, Elaine Antonio, appealed the Planning Commission’s decision.
In her appeal, Antonio said that the proposed condominium building was too big for the neighborhood and that the project would cause traffic congestion.
However, the building design is under the maximum allowable height and the Planning Commission agreed with city staff that the overall building massing is appropriate for the site, Fogarty said.
Also, the Environmental Analysis found that the project would not result in any significant traffic impacts, Fogarty said.
In her appeal, Antonio also said that there is a need for the convalescent care center, which closed in November and is expected to be demolished.
“There are not enough nursing homes left in Santa Monica,” Antonio said. “I believe we’re losing them rapidly and pretty soon there won’t be any. And this was a particularly good one.”
Although the convalescent care center is closed, Councilman Kevin McKeown pointed out that the Planning Commission has initiated a new study on the need for convalescent care in Santa Monica. The study is under way and not complete, McKeown said.
Antonio also claimed that the public process was circumvented by the developer, who allegedly made a death threat to a person opposed to the project.
Antonio and several neighbors were concerned about Santa Monica losing nursing homes, so they decided to write letters to the city opposing the condominium project.
“One of my neighbors sent in their letter a week earlier than the rest of us,” Antonio said. “That neighbor received a phone call from someone that said they were the developer of the project. They did not name themselves, but they had a Middle Eastern accent. That person who claimed they were the developer said that if my neighbor did not rescind their letter, that they would be killed. And they said it three times to them and then spit into the phone.”
The neighbor who received the alleged death threat called the Planning Department and rescinded the letter.
The City Attorney’s office was contacted about the allegations, as was the Santa Monica Police Department. An investigation was conducted, but there was insufficient evidence to warrant any further law enforcement activity, Fogarty said. Also, the victim of the alleged threat was unwilling to make a statement.
City Attorney Marsha Moutrie said she spoke to the Santa Monica Police Department, which confirmed that the alleged victim appeared frightened.
“I tried to convince the neighbor who received the death threats to come forward, but unfortunately, death threats can be extremely effective,” said Antonio. “And when people receive them, they believe them. Citizens should be able to participate in their government without fear of reprisal.”
Kevin Kozal, the developer’s attorney, said he had heard nothing before then about the death threat.
“I have absolutely no knowledge of any of those threats being made,” Kozal said. “The appeal did not set forth any partic- ulars. Tonight is the first time we have heard information about that. It’s hearsay; there’s no direct evidence.”
Several councilmembers seemed concerned.
“The allegations are very disturbing,” said McKeown.
“There is no place for threats in the public process in Santa Monica or anywhere else, as far as I’m concerned,” Councilman Bob Holbrook said. “I’ve had threats personally since I’ve been a member of the council and I don’t think I took them seriously, but I can tell you that my family did.”
Mayor Herb Katz thanked Antonio for her courage to speak out.
“We will do everything we can to see this doesn’t happen again,” Katz said.
McKeown made a motion to direct staff — to the extent possible — to further investigate the allegations and return to the council with suggested procedures to use, should a similar situation arise in the future.
Antonio’s appeal was unanimously denied by the City Council.
“I don’t mean to be insensitive to the issues that were raised by the appellant because I think they are serious and I think we need to take them seriously, but I don’t think this is the context in which we can do it,” said Councilman Ken Genser. “So I’ll move that we reject the appeal and uphold the decision of the Planning Commission.”
With the appeal being denied and the Planning Commission’s approval upheld, the applicant has the go-ahead to start construction of the three-story, 35-foot-high, 27,550-square-foot, condominium complex that includes a central courtyard with a fountain, landscaping and a 42-space subterranean garage.


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Browsing by Advisor "Mparmpakas, Dionysios"
Now showing items 1-1 of 1
Body weight, height and alimentary tendences in ages of 6-12 years: recording in the regions «Metamorphosis» and «Kalamaki» of Attiki.T.E.I. of Crete, School of Agriculture, Food and Nutrition (STeGTET), Department of Nutrition and Dietetics
Publication Date: 28-02-2008This essay examines eating habits of children aged between 6 and 12 as well as the probability of appearance of obesity at this age. In fact childhood obesity tends to have the proportions of an epidemic nowadays and is ...

domain: medical


Dynamic light scattering has been vastly explored as a tool for micelles characterization, not only for their size and stability, but also to determine the critical micellization concentration (CMC) and temperature (CMT)1-3. As a result of the unimers aggregation, as a function of the temperature for the case of this study, an increase in the scattered intensity is expected due to larger particles scattering substantially more photons. It’s been reported that for light-scattering techniques to be used reliably as CMC or CMT determination techniques, long correlation times are needed 1,4,5 which make this time-consuming and hence it’s not usually considered as a primary technique. We suggest in this application note, that DLS can be used in conjugation with other techniques to determine the CMT in a highly reproducible and time-efficient manner.
Dynamic light scattering has been vastly explored as a tool for micelles characterization, not only for their size and stability but also to determine the critical micellization concentration (CMC) and temperature (CMT)1-3. As a result of the unimers aggregation, as a function of the temperature for the case of this study, an increase in the scattered intensity is expected due to larger particles scattering substantially more photons. It’s been reported that for light-scattering techniques to be used reliably as CMC or CMT determination techniques, long correlation times are needed 1,4,5 which makes this time-consuming and hence it’s not usually considered as a primary technique. We suggest in this application note, that DLS can be used in conjugation with other techniques to determine the CMT in a highly reproducible and time-efficient manner. For a more comprehensive introduction on the topic and how the Zetasizer Nano could be used for CMC determination, the readers are referred to Ref.  and to Malvern Panalytical’s previous application note “Surfactant micelle characterization using dynamic light scattering”.
All measurements described in this application note were performed with Malvern Panalytical’s Zetasizer Ultra. The surfactant used was Pluronics F-68 (poloxamer 188, Sigma), a triblock co-polymer composed of polyethylene oxide (PEO) and polypropylene oxide (PPO) with a general structure of PEO-PPO-PEO. This polymer was selected due to it showing a transition from unimer to micelle at relatively high temperatures, and therefore its CMT could be investigated by DLS. For the CMT determination, the derived count rate was monitored at a back-scattering angle of detection, at 1°C increments from 40°C – 70°C. Adaptive Correlation was used to reduce the effect of transient events (contaminants, dust particles and aggregates) on the final result and allow for a more sensitive determination of the unimer/micelle transition point. This was performed for 5 different concentrations, ranging from 1.25 mg/mL to 20 mg/mL, to evaluate the effect of concentration on the CMT. A multi-angle dynamic light scattering measurement (back, side and forward scatter detectors) was also run to try to resolve the transition stage, which requires a higher resolution size analysis, and these were reported as intensity-weighted distribution plots. Each temperature point was performed in triplicates.
A 10 mg/mL solution of F-68 in water was first analyzed on the Zetasizer Ultra at different temperature points. Considering F-68 known behavior of forming micelles at higher temperatures it was expected that the derived count rate (the count rate obtained taking into consideration the attenuation factor used), would show an inflection point at the temperature where micelles start to form. This would be accentuated due to larger particles scattering considerably more photons, since according to Rayleigh theory intensity = diameter6, for Rayleigh scatterers (dh < 1/10 λlaser).
The effect in the derived count was substantial and the inflection point (or the CMT) was easily discernible at the intersect between the two lines, as demonstrated in Figure 1. For the initial temperature range, from 40°C – 51°C the count rate did not vary significantly, and hence a straight line was applied to the data points. Conversely, from 52°C upwards, a rapid increase in the number of photons detected occurred, and to this part of the data points, a 3rd degree polynomial was applied, since it showed the highest correlation coefficient value (R2 = 0.9989). The CMT can then be identified as the temperature at which the two lines intersect, 52°C.
Figure 1 – Derived count rates for the sample F-68 (10 mg/mL) at different temperatures, showing an inflection point around 52°C – the temperature at which micelles start to be formed (CMT). This analysis was performed in triplicates.
With increasing concentration, it was noted that the CMT decreased by several degrees Celsius (Figure 2). This has been ascribed to the reduced hydration at higher concentrations and thus, at high temperatures, the increased hydrophobicity of the polymer molecules4.
Figure 2 – Concentration dependence of the F-68’s CMT.
These samples were also run in parallel in a differential scanning calorimetry (DSC) instrument. Each CMT point obtained in DLS varied on average 0.5°C to those obtained in the DSC, showing the feasibility of the method described here.
Dynamic light scattering as a technique is known to produce low resolution results, particularly in the presence of similarly sized modes. The multi-angle dynamic light scattering (MADLS) feature in the Zetasizer Ultra, allows for a higher resolution size determination of multimodal samples, by using the three different angles (back, side and forward scattering detection) and combining the information obtained into one size distribution plot. This allowed for a better resolved size distribution at the CMT, where both unimers and micelles are present, as shown in Figure 3. Furthermore, when each angle was individually analyzed it was not possible to discriminate the modes for the unimer and micelle, proving that the MADLS analysis gives a higher resolution result (Figure 4).
Figure 3 – Multi-angle dynamic light (MADLS) scattering result for the sample F-68 (10 mg/mL) at different temperatures, showing the transition from unimers to micelles.
Figure 4 – Comparison between the MADLS result (a) and the 3 individual angle measurements (b) for the 10 mg/mL F-68 at 53°C (above CMT; red, green and blue colors represent back, side and forward detection angles, respectively).
It has been shown in this application note that the Zetasizer Ultra can be used to determine the critical micellization temperature of Pluronic surfactants. In contrast with previous light-scattering studies, the Zetasizer Ultra can significantly decrease the measurement time and simplify the experimental procedure. It does not require numerous sample filtrations and long data collection times. Moreover, the MADLS measurements allows for a higher resolution size distribution plot to be obtained which makes it possible for better monitoring of the transition stage between micelles and unimers.
1. Alexandridis, P. & Alan Hatton, T. Poly(ethylene oxide) poly(propylene oxide) poly(ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling. Colloids Surfaces A Physicochem. Eng. Asp. 96, 1–46 (1995).
2. Gaucher, G. et al. Block copolymer micelles: Preparation, characterization and application in drug delivery. J. Control. Release 109, 169–188 (2005).
3. Yeon, C., Lee, I., Kim, G. H. & Yun, S. J. Unimer-Assisted Exfoliation for Highly Concentrated Aqueous Dispersion Solutions of Single- and Few-Layered van der Waals Materials. Langmuir 33, 1217–1226 (2017).
4. Zhou, Z. K. & Chu, B. Light-Scattering Study on the Association Behavior of Triblock Polymers of Ethylene-Oxide and Propylene-Oxide in Aqueous-Solution. J. Colloid Interface Sci. 126, 171–180 (1988).
5. Matsuoka, H., Moriya, S. & Yusa, S. ichi. Fundamental properties, self-assembling behavior, and their temperature and salt responsivity of ionic amphiphilic diblock copolymer having poly(N-isopropylacrylamide) in aqueous solution. Colloid Polym. Sci. 296, 77–88 (2018)


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Yesterday the residents made a very delicious and easy recipe of strawberry cheesecake ice cream. You don’t have to have an ice cream machine to make this!
-1 16-oz. pkg. fresh strawberries, hulled
-1/4 cup sugar
-1 teaspoon vanilla
-juice from 1/2 lemon
-1 pint heavy whipping cream
-1 can (14 oz.) sweetened condensed milk
-4 oz. cream cheese, room temperature
-1/2 cup crushed graham cracker
1. For the strawberry sauce, combine strawberries, sugar, vanilla and lemon juice in a medium saucepan.
2. Cook over medium heat until sugar dissolves and the strawberries soften, 6-8 minutes. You may need to break the strawberries down a bit with a fork or a potato masher.
3. Transfer sauce to a bowl and refrigerate until cool.
4. For the ice cream, using a hand held mixer, begin by whipping the cream cheese until smooth. Add the sweetened condensed milk and continue beating until smooth.
5. In a separate bowl, using the hand mixer with whisk attachments, whip the heavy whipping cream until stiff peaks form.
6. Folk whipped cream gently into the cream cheese mixture.
7. Pour half the whipped cream mixture into a 9×5 loaf pan.
8. Drizzle with strawberry sauce and 1/4 cup crushed graham crackers and using a butter knife, swirl.
9. Pour remaining whipped cream mixture on top.
10. Drizzle with remaining strawberry sauce and graham cracker.
11. Swirl again.
12. Freeze for 4-8 hours or overnight.
Another hit the residents made this week was Hawaiian pizza dip.
-1 8 oz. block cream cheese, softened
-2 green onions, chopped
-1/2 cup diced, sliced ham
-1/2 cup crushed pineapple, drained
-1 cup cheddar cheese + 1/2 cup mozzarella cheese combined
1. Preheat oven to 350 degrees Fahrenheit.
2. In a bowl combine cream cheese, ham, pineapple, and 1 cup cheeses.
3. Mix until well combined then transfer to oven safe dish.
4. Bake for about 15 minutes until bubbly then top with remaining cheese and return to oven for about 5 more minutes or until cheese is melted.
5. Serve with chips or bread.


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Digital literacy is an increasingly important aspect of education. This summer Paige Cross ’13, Trevor Howe ’13, and Kara Vetrano ’13 examined the use of digital technology to adults trying to obtain their GED through the five Literacy Zones in Utica. The group completed this project, entitled “Organizing to Teach Literacy, Reading Cultural Significance,” as a Levitt Summer Group Research Grant under the direction of Associate Professor of Anthropology Chaise LaDousa.
There are five literacy zone classrooms in Utica: two on the west side of the city, Utica Access Site (BOCES), St. Martin’s de Porres and the Utica Public Library, and three on the east, Kernan Elementary School and Resource Center for Independent Living. These literacy centers each have programs for adults studying for the GED, ranging from younger students who dropped out of high school, to older students who were laid off work and now need a GED to obtain employment, to refugees.
Cross, Howe, and Vetrano worked at these literacy centers tutoring students studying for the GED using a computer program called the Broadband Technologies Opportunity (BTOP). The program, developed by Portland State University, is intended to increase computer literacy by incorporating computer skills into the GED curriculum, and to therefore fill in the “digital divide” among the poor, elderly, and undereducated. The literacy centers are obligated to use BTOP in order to receive funding from the state. The Hamilton students each worked at different literacy centers and picked a topic of particular interest to them to incorporate into the group paper. Vetrano focused on the relationship between GED attainment and BTOP, while Cross examined the GED exam itself, specifically the changes caused by one of the largest for-profit education companies in the US buying the rights to the exam from the a non-profit, the previous owner. Howe focused his research on how programs like BTOP are being used in low income areas to try to close the “digital divide” that is often attributed to be a cause of poverty. Their fieldwork consisted of tutoring students, observing, and interviewing teachers. In addition to preparation at the beginning and time at the end to transcribe interviews and write the final paper, the students spent about ten weeks on the project.
Through observations and interviews, Vetrano reports that the administration had a very different perspective of the literacy center than the teachers and students, a result of the structure of the center itself. “The administration was positioned at the macro level and had little interaction with students, while the teachers interacted with students on a daily basis,” she said. In practice, as the students, teachers, and the Hamilton researchers experienced, BTOP had a lot of mishaps: broken links, a confusing layout, and often covered material that was not relevant to the students. The administration rarely had contact with BTOP, however. As a result, Vetrano found that they maintained a theoretical, idealistic perspective of BTOP and its relationship to GED attainment, while the teachers and students held a more realistic view of BTOP and the limited impact the program has on students’ lives.
Cross noted that the changes that will occur in the GED in 2013 as a result of being bought by a private company will create further challenges for low income students. It will be more expensive, which means that the state may not be able to completely subsidize the cost of the test for residents in the future. It will also become more difficult, and will only be offered on a computer. “This is a problem because many people taking the exam have little experience using a computer,” said Cross, and their research showed that BTOP is doing little to help in practice. “These changes are making the education gap more defined,” according to Cross.
Howe found that the language in BTOP suggests that when someone is not able to use digital technologies they are seen as being disadvantaged in the job market and in academia. “I also found,” he reported, “that one cannot talk about digital literacy without acknowledging factors such as race, immigration status, and family income.”
Cross, Howe and Vetrano reported that their summer research was extremely valuable for understanding students’ experiences with literacy and language in Utica. Howe said that he had never previously paid any attention to the term “digital literacy,” and was excited to have to opportunity to explore it after hearing about the Hamilton students’ findings from last summer. “This was a great opportunity to take part in field work and learn the necessary skills and methods,” said Vetrano.

domain: news


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Are you looking to add gross and icky to your Halloween party snack table!? You’ve found the perfect recipe.
Bones in Ghoul Dip is quick and easy to make. This recipe will be a hit at the dinner table, as an evening snack, or at a Halloween party.
Contributed by: Chrissie


Opponents of oil and gas ordinance met with obstacles to providing comment
October 19, 2017 10:30 PM
BERNALILLO, N.M. – After it was announced the oil and gas ordinance would not be an action item on the agenda at Thursday night's Sandoval County Commission meeting, people were given the opportunity to leave.
While some took it, others stuck around. Those who stayed were met with the news they would no longer be given three minutes to speak on the legislation.
Instead, those wanting to give public comment were given just 60 seconds.
One person who did comment asked county commissioners to consider a bigger venue for the next meeting. The fire marshal was present like at previous meetings, ready to enforce the 122-person limit inside the room. That left many ordinance protesters outside without a seat.
The 1-minute limit was difficult for speakers to stick to while they voiced their opinion, and some even held fracking noise demonstrations.
Despite all the opposition, KOB caught up with the only supporter of the ordinance to speak at the meeting, who stressed the importance of compromise.
“To me, it's important to articulate that there are opportunities available if we can strike the right balance between the public safety and economic development, which is not a choice,” Miguel Suazo said. “You can have both, and provide the people of New Mexico (with) the jobs they need and deserve.”
The ordinance is set to be published in the Albuquerque Journal Sunday, and voted on at the Sandoval County Commission’s Nov. 16 meeting.
Updated: October 19, 2017 10:30 PM
Created: October 19, 2017 10:10 PM
Copyright 2017 KOB-TV LLC, a Hubbard Broadcasting Company. All rights reserved


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Tan YW, Chen L, Zhou XB. Efficacy of artificial liver support system in severe immune-associated hepatitis caused by camrelizumab: A case report and review of the literature. World J Clin Cases 2021; 9(17): 4415-4422 [PMID: 34141809 DOI: 10.12998/wjcc.v9.i17.4415]
Corresponding Author of This Article
You-Wen Tan, MD, Chief Doctor, Professor, Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University, No. 300 Danjiamen, Runzhou District, Zhenjiang 212003, Jiangsu Province, China. firstname.lastname@example.org
Checklist of Responsibilities for the Scientific Editor of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Author contributions: Tan YW and Chen L designed the research; Zhou XB collected and analyzed the data, and drafted the manuscript; Tan YW wrote and revised the manuscript; all authors have read and approved the final version to be published.
Informed consent statement: Informed consent was obtained from the patient.
Conflict-of-interest statement: All authors have no conflict of interest related to the manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: You-Wen Tan, MD, Chief Doctor, Professor, Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University, No. 300 Danjiamen, Runzhou District, Zhenjiang 212003, Jiangsu Province, China. email@example.com
Received: February 4, 2021 Peer-review started: February 4, 2021 First decision: February 24, 2021 Revised: February 27, 2021 Accepted: March 25, 2021 Article in press: March 25, 2021 Published online: June 16, 2021
Immune checkpoint inhibitors (ICIs) can lead to immune-related hepatitis (IRH) and severe liver damage, which is life-threatening in the absence of specific treatment.
A 75-year-old man was admitted to our hospital complaining of loss of appetite, yellow urine, and abnormal liver function for the past 2 wk. Three months prior to admission, he was treated with two rounds of capecitabine in combination with camrelizumab for lymph node metastasis of esophageal cancer. Although liver function was normal before treatment, abnormal liver function appeared at week 5. Capecitabine and camrelizumab were discontinued. Ursodeoxycholic acid and methylprednisolone 40 mg daily were administered. Liver function continued to deteriorate. Prothrombin time and international normalized ratio were 19 s and 1.8, respectively. The patient was diagnosed with acute liver failure. A pathological analysis of liver biopsy indicated a strongly positive immunohistochemical staining of T8+ cells, thereby suggesting that drug-induced liver injury was related to IRH caused by camrelizumab. Subsequently, we performed sequential dual-molecule plasma adsorption system (DPMAS) treatment with plasma exchange (PE). After two rounds of treatment, the patient's appetite significantly improved, the yellow color of urine reduced, and liver function improved (total bilirubin level decreased) after five rounds of treatment. Liver function normalized 4 wk after discharge.
The use of sequential DPMAS with PE can reduce liver injury and systemic toxic reactions by clearing inflammatory mediators and harmful substances from blood, and regulate immune cell activity, which may be effective in the treatment of severe ICI-induced IRH.
Core Tip: Immune checkpoint inhibitors can lead to immune-associated hepatitis and severe liver damage that can be life-threatening without specific treatment. Corticosteroids and immunosuppressants do not show sufficient sensitivity and their use often leads to serious complications such as severe secondary infections. Here we report a case of severe liver damage caused by death protein 1 inhibitors and the first use of dual-molecule plasma adsorption combined with plasma exchange to achieve satisfactory results. In addition, the clinical biochemical indicators in this case were sufficient for diagnosing acute liver failure, while pathology provided an accurate diagnosis. Pathological diagnosis is a very important diagnostic tool for severe liver injury.
Citation: Tan YW, Chen L, Zhou XB. Efficacy of artificial liver support system in severe immune-associated hepatitis caused by camrelizumab: A case report and review of the literature. World J Clin Cases 2021; 9(17): 4415-4422
Immune checkpoint inhibitors (ICIs) target programmed cell death protein 1 (PD-1)/programmed cell death protein ligand 1 (PD-L1); cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) monoclonal antibodies can enhance the anti-tumor immune response in the human body by blocking the inhibitory immunoregulation of the above-mentioned immune checkpoint pathway. Since tumor and normal cells have similar antigens, an activated immune system can simultaneously kill the tumor and attack normal human tissues, causing immune-related adverse reactions in various systems of the body[2,3]. Immune-related adverse events (irAEs) can affect all organs. ICI-related hepatitis (IRH) is a common irAE. When the degree of liver injury is grade 1 or 2, most of them can relieve themselves. Since corticosteroids and immunosuppressant treatment are difficult to achieve good curative effect in grades 3 and 4 liver injury, deaths are common. We report a case wherein the first use of dual-molecule plasma adsorption system (DPMAS) combined with plasma exchange (PE) achieved satisfactory results in a patient with severe liver damage caused by PD-1 inhibitors.
A 75-year-old man with esophageal cancer was admitted to the hospital 1 year after surgery.
History of present illness
The patient presented with a 2 wk history of loss of appetite, yellow urine, and abnormal liver function. Three months prior, due to lymph node metastasis of esophageal cancer, the patient was placed on capecitabine (1.5 g) twice daily for 2 consecutive weeks, followed by a 1 wk interval, combined with 200 mg of camrelizumab (PD-1 inhibitor) twice every 2 wk.
History of past illness
There was no family history of viral hepatitis; no history of alcohol abuse, blood transfusion, use of blood products, or schistosomiasis; and no recent history of an unclean diet.
Personal and family history
There was no history of contact with the novel coronavirus. The patient’s family members were healthy. He had no history of tuberculosis or other infectious diseases, and there was no family history of genetic disease.
Physical examination revealed the following: Blood pressure, 122/82 mmHg; heart rate, 67 beats/min; respiratory rate, 18 breaths/min; and body temperature, 36.5 °C. His skin was dark and dull, and yellowing of the skin and sclera was observed.
Other findings included: There was no palmar erythema, no spider nevi, and no obvious abnormal findings during cardiopulmonary auscultation; the abdomen was soft, non-distended, and non-tender; and there was no rebound tenderness. Mobility dullness was negative, and no edema was noted on either leg.
Liver function, monitored weekly, was normal in the first 4 wk and abnormal in the fifth week. The capecitabine and camrelizumab were discontinued; however, the patient’s liver function continued to deteriorate (Figure 1). The patient had no history of hepatitis A-E or alcoholism; analyses for Epstein-Barr, cytomegalovirus, and antinuclear and mitochondrial antibodies were negative.
Figure 1 Flow chart of liver function change and treatment intervention.
LB: Liver biopsy; MP: Methylprednisolone; DPMAS: Dual plasma molecular adsorption system; PE: Plasma exchange; TBIL: Total bilirubin; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; UDCA: Ursodeoxycholic acid; INR: International normalized ratio.
Abdominal ultrasound and magnetic resonance cholangiopancreatography (MRCP) were performed to exclude biliary obstruction.
The patient was clinically diagnosed with acute liver failure. Pathological analysis of the liver biopsy showed extensive acinar inflammation and necrosis, cholestasis, bile duct injury, infiltration of a large number of eosinophils, and strong immunohistochemical staining of T8+ cells. Therefore, the patient was diagnosed with drug-induced liver injury (Figure 2) linked to IRH caused by camrelizumab.
Figure 2 Pathological findings of liver biopsy.
A: Zone 3 and surrounding lobular inflammation (arrow), bile lake (long arrow), and hematoxylin-eosin staining, 200 ×; B: A large number of eosinophils (arrow) and macrophage phagocyte waxy material (long arrow), Periodic Acid-Schiff with diastase, 200 ×; C: CD4+ T cells (arrow), CD4+ T immunohistochemical staining, 200 ×; D: CD8+ T cells (arrow), CD8+ T immunohistochemical staining, 200 ×.
The patient was administered ursodeoxycholic acid (UDCA) and methylprednisolone (MP) 40 mg daily. His alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels decreased; however, his serum total bilirubin (TBIL), alkaline phosphatase (ALP), and glutamine transpeptidase (GGT) levels increased further (Figure 1). The prothrombin time was 19 s and the international normalized ratio was 1.8. The patient exhibited a poor clinical response to corticosteroids; therefore, the treatment was stopped after 10 d. He was placed on DPMAS and sequential PE every 2-3 d. The treatment method was as follows: Femoral vein puncture was performed, bleeding fluid was drained through the plasma separator to separate blood cells and plasma, and the anion bilirubin adsorption column (Zhuhai Jianfan, China; BS330) and HA-type resin hemoperfusion device (Zhuhai Jianfan, China; HA330-II) were used for plasma adsorption; the plasma treatment volume was 6500 (operation procedure, Figure 3). At the end of the DPMAS cycle, the plasma in the adsorption column was recovered using a single blood pump, while the plasma separator was left to continue the PE. The exchange volume was 1500 mL.
After two rounds of DPMAS + PE, the patient's appetite significantly improved, the yellow color of urine was alleviated, and the UDCA treatment was continued. After five rounds of treatment. Liver function was normal at 4 wk after discharge. No abnormal liver function was found, and the capecitabine treatment was continued.
The incidences of IRH caused by CTLA-4 and PD-1/PD-L1 inhibitors are less than 10% and approximately 5%, respectively[8,9]. Its incidence with combined CTLA-4 inhibitor use is as high as 33%, and grade 3-4 liver injury accounted for approximately 14%[10,11]. IRH often develops more than 1-3 mo after administration, but it can appear at any time. The incidence of IRH was higher in hepatocellular carcinoma patients treated with two kinds of ICIs and CTLA-4 inhibitor combined with chemotherapy/targeted therapy than in those treated with PD-1 inhibitor alone.
The main clinical manifestations of liver injury associated with ICI include asymptomatic ALT and/or AST elevations, with or without TBIL elevation; moreover, some patients present with symptoms such as fever, fatigue, jaundice, and fullness. Most patients with mild hepatitis present normal imaging findings; furthermore, patients with moderate to severe hepatitis have non-specific manifestations such as hepatomegaly, periportal edema, and periportal lymphadenopathy. Common pathological features include lobular hepatitis, central inflammation, and necrosis; portal lesions are often mild[13,14]. CTLA-4 inhibitors cause similar CD4+ and CD8+ T cell infiltrations in liver tissue, and PD-1/PD-L1 inhibitors mainly lead to CD8+ T cell infiltration[16,17]. In this case report, we also showed strong CD8+ T cell positivity in liver tissue. Bile duct injury is also a common pathological manifestation, especially in patients with cholestasis and high jaundice. We recently found the case of a patient with bile duct deficiency (unpublished). Some scholars have reported the existence of specific granulomas, such as fibrotic granulomas, but only in case reports[19,20].
In order to diagnose ICI-related hepatitis, it is necessary to exclude active viral hepatitis, alcoholic hepatitis, autoimmune hepatitis, thromboembolic events, metastatic disease progression, and other liver diseases, and to investigate the effect of the combination of drugs (such as acetaminophen, antibiotics, and chemotherapy drugs). In this case, we used capecitabine and camrelizumab simultaneously, and therefore it was difficult to determine whether IRH was caused by capecitabine. After liver function is repaired, there is no abnormal liver function after using capecitabine again. The Roussel Uclaf causality assessment method was used to score. The total score of 1 (time to onset + 2; course, 0; risk factors, + 1; concomitant drug, - 1; search for non-drug cases, + 1; previous information on drug hepatotoxicity, 0; response to drug readministration, - 2) also excluded the correlation between liver injury occurrence and capecitabine use.
The National Cancer Institute grades the severity of hepatotoxicity according to the common terminology criteria for adverse events version 4.03 (Table 1). Grade 1 [AST/ALT > 3 ×, ALP/GGT > 2.5 ×, total bilirubin (TB) > 1.5 × upper limit of normal (ULN), and TBIL < 1.5 × ULN] patients usually can continue to use ICIs. Grade 2 (AST/ALT > 3-5 ×, ALP/GGT > 2.5-5 ×, and TB > 1.5-3 × ULN) requires ICI discontinuation and oral prednisone intake 0.5-1 mg/kg/d, which is gradually reduced in one month; Grade 3 (AST/ALT/ALP/GGT > 5-20 × and TB > 3-10 × ULN) and Grade 4 (AST/ALT/ALP/GGT > 20 × and TB > 3-10 × ULN) require ICI discontinuation; if there is no improvement after 3 d, methylprednisone 0.5-1 g bid or antithymocyte globulin should be added. Infliximab is not recommended because of its potential risk of liver failure[23,24].
Table 1 Severity grading of immune checkpoint inhibitor-induced hepatotoxicity according to National Cancer Institute’s common terminology criteria for adverse events version 4.03.
ICI-associated cholestatic hepatitis (mainly bilirubin, with ALP and gamma GGT levels elevation) has also been reported, and may be corticosteroid-resistant, with a poor prognosis. However, abdominal ultrasound or MRCP is needed to exclude biliary obstruction factors. In a study of 387 patients from Japan who underwent ICI treatment, 56 developed corticotropin releasing hormone, 11 (19.6%) of the hepatocellular type and 34 (60.7%) of the cholestasis type, with cholestasis predominating. Liver biopsy is helpful in diagnosing and evaluating the severity of hepatitis and guiding individualized treatment, which is necessary in complex, severe, and refractory cases. Although MP (40 mg/d) was administered to this patient in the rising stage of jaundice, ALT and AST levels decreased while ALP, GGT, and TBIL levels increased instead of decreasing. Obviously, it is resistant to corticosteroids. Liver biopsy showed that, in addition to extensive lobular inflammation, there was bile duct injury and severe cholestasis. No massive or submassive necrosis was found, and acute liver failure was not diagnosed, which was consistent with the pathological manifestations of cholestatic hepatitis.
Blood adsorption technology is a type of blood purification method that uses different adsorbents to remove endogenous or exogenous poisons in blood. In order to reduce adsorbent-induced blood cell damage, plasma separation technology can be combined with it to adsorb the separated plasma, namely, plasma adsorption. DPMAS can improve hyperbilirubinemia, clear inflammatory factors, reduce inflammatory response syndrome, block the occurrence and development of liver failure, and significantly improve the prognosis of liver failure[28,29]. DPMAS can process more than 6000 mL of plasma at one time. We previously used DPMAS and sequential PE for the treatment of thyroid crisis and severe liver injury. Moreover, we used DPMAS to treat a patient with severe ICI-related liver injury. The patient's liver function improved for a while. However, due to long-term corticosteroid and multimode fiber (MMF) treatment, severe secondary infection and septic shock occurred, and the patient finally died of multiple organ failure. Nevertheless, it can be seen that this combination can conveniently repair liver injury with severe cholestasis.
A previous study reported that a 76-year-old patient with malignant melanoma developed liver function deterioration (abnormal TBIL and ALP levels) after using ipilimumab (anti-CTLA-4). Corticosteroids (2 mg/kg/d) and MMF (1.5 g/d) did not prevent the progression of liver failure. Finally, the patient was treated with PE for five times, and the corticosteroids and MMF were simultaneously reduced. DPMAS combined with PE has a curative effect on ICI-related liver injury because it can remove inflammatory factors, bilirubin, creatinine, and other small molecular substances from blood. Other possible mechanisms include changes in lymphocyte proliferation and function, which may render lymphocytes sensitive to immunosuppressants and chemotherapy drugs, as well as changes in the immune system, including changes in the number and activation of B and T cells, the enhancement of T-suppressive function, and changes in the ratio of helper T cell type 1/2 (Th1/Th2). The changes in the number and function of these immunocompetent cells reduce the severity of ICI-related liver injury.
Recently, six cases were reported concerning patients with high-grade ICI-related hepatitis with spontaneous liver function improvement without corticosteroid therapy. This showed the importance of individualized treatment according to biological and histological severity, with the possibility of avoiding unnecessary systemic cortisol treatment. In general, severe liver injuries caused by ICIs are rare. Most liver injuries of grades 3-4 or higher are sensitive to corticosteroid therapy, while mild liver injuries can be relieved without corticosteroid therapy.
Manuscript source: Unsolicited manuscript
Specialty type: Medicine, research and experimental
Huffman BM, Kottschade LA, Kamath PS, Markovic SN. Hepatotoxicity After Immune Checkpoint Inhibitor Therapy in Melanoma: Natural Progression and Management.Am J Clin Oncol. 2018;41:760-765.
Bhave P, Buckle A, Sandhu S, Sood S. Mortality due to immunotherapy related hepatitis.J Hepatol. 2018;69:976-978.
Naidoo J, Page DB, Li BT, Connell LC, Schindler K, Lacouture ME, Postow MA, Wolchok JD. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies.Ann Oncol. 2016;27:1362.
Larkin J, Hodi FS, Wolchok JD. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.N Engl J Med. 2015;373:1270-1271.
Valsecchi ME. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.N Engl J Med. 2015;373:1270.
Parlati L, Vallet-Pichard A, Batista R, Hernvann A, Sogni P, Pol S, Mallet V; CERTIM group. Incidence of grade 3-4 Liver injury under immune checkpoints inhibitors: A retrospective study.J Hepatol. 2018;69:1396-1397.
Naidoo J, Page DB, Li BT, Connell LC, Schindler K, Lacouture ME, Postow MA, Wolchok JD. Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies.Ann Oncol. 2015;26:2375-2391.
Kimura H, Takeda A, Kikukawa T, Hasegawa I, Mino T, Uchida-Kobayashi S, Ohsawa M, Itoh Y. Liver injury after methylprednisolone pulse therapy in multiple sclerosis is usually due to idiosyncratic drug-induced toxicity rather than autoimmune hepatitis.Mult Scler Relat Disord. 2020;42:102065.
Kleiner DE, Berman D. Pathologic changes in ipilimumab-related hepatitis in patients with metastatic melanoma.Dig Dis Sci. 2012;57:2233-2240.
De Martin E, Michot JM, Papouin B, Champiat S, Mateus C, Lambotte O, Roche B, Antonini TM, Coilly A, Laghouati S, Robert C, Marabelle A, Guettier C, Samuel D. Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors.J Hepatol. 2018;68:1181-1190.
Johncilla M, Misdraji J, Pratt DS, Agoston AT, Lauwers GY, Srivastava A, Doyle LA. Ipilimumab-associated Hepatitis: Clinicopathologic Characterization in a Series of 11 Cases.Am J Surg Pathol. 2015;39:1075-1084.
Zen Y, Yeh MM. Hepatotoxicity of immune checkpoint inhibitors: a histology study of seven cases in comparison with autoimmune hepatitis and idiosyncratic drug-induced liver injury.Mod Pathol. 2018;31:965-973.
Wu Z, Lai L, Li M, Zhang L, Zhang W. Acute liver failure caused by pembrolizumab in a patient with pulmonary metastatic liver cancer: A case report.Medicine (Baltimore). 2017;96:e9431.
Simonelli M, Di Tommaso L, Baretti M, Santoro A. Pathological characterization of nivolumab-related liver injury in a patient with glioblastoma.Immunotherapy. 2016;8:1363-1369.
Everett J, Srivastava A, Misdraji J. Fibrin Ring Granulomas in Checkpoint Inhibitor-induced Hepatitis.Am J Surg Pathol. 2017;41:134-137.
Becker MW, Lunardelli MJM, Tovo CV, Blatt CR. Drug and herb-induced liver injury: A critical review of Brazilian cases with proposals for the improvement of causality assessment using RUCAM.Ann Hepatol. 2019;18:742-750.
Peeraphatdit TB, Wang J, Odenwald MA, Hu S, Hart J, Charlton MR. Hepatotoxicity From Immune Checkpoint Inhibitors: A Systematic Review and Management Recommendation.Hepatology. 2020;72:315-329.
Simonaggio A, Michot JM, Voisin AL, Le Pavec J, Collins M, Lallart A, Cengizalp G, Vozy A, Laparra A, Varga A, Hollebecque A, Champiat S, Marabelle A, Massard C, Lambotte O. Evaluation of Readministration of Immune Checkpoint Inhibitors After Immune-Related Adverse Events in Patients With Cancer.JAMA Oncol. 2019;.
Kok B, Lester ELW, Lee WM, Hanje AJ, Stravitz RT, Girgis S, Patel V, Peck JR, Esber C, Karvellas CJ; United States Acute Liver Failure Study Group. Acute Liver Failure from Tumor Necrosis Factor-α Antagonists: Report of Four Cases and Literature Review.Dig Dis Sci. 2018;63:1654-1666.
Doherty GJ, Duckworth AM, Davies SE, Mells GF, Brais R, Harden SV, Parkinson CA, Corrie PG. Severe steroid-resistant anti-PD1 T-cell checkpoint inhibitor-induced hepatotoxicity driven by biliary injury.ESMO Open. 2017;2:e000268.
Imoto K, Kohjima M, Hioki T, Kurashige T, Kurokawa M, Tashiro S, Suzuki H, Kuwano A, Tanaka M, Okada S, Kato M, Ogawa Y. Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients.Can J Gastroenterol Hepatol. 2019;2019:6391712.
Wu M, Zhang H, Huang Y, Wu W, Huang J, Yan D. Efficiency of Double Plasma Molecular Absorption System on the Acute Severe Cholestatic Hepatitis.Blood Purif. 2021;1-7.
Chen G, Wu M, Wu B, Liu F, Liu J, Liu L. Effects of dual plasma molecular adsorption system on liver function, electrolytes, inflammation, and immunity in patients with chronic severe hepatitis.J Clin Lab Anal. 2019;33:e22926.
Yan GS, Li LL, Jiang SL, Meng S, Wu CC. [Clinical study of different adsorbents with dual plasma molecular adsorption system in the treatment of hepatic failure].Zhonghua Gan Zang Bing Za Zhi. 2019;27:51-55.
Tan YW, Sun L, Zhang K, Zhu L. Therapeutic plasma exchange and a double plasma molecular absorption system in the treatment of thyroid storm with severe liver injury: A case report.World J Clin Cases. 2019;7:1184-1190.
Bernuau J. High volume plasma exchange in patients with acute liver failure.J Hepatol. 2016;65:646-647.
Reeves HM, Winters JL. The mechanisms of action of plasma exchange.Br J Haematol. 2014;164:342-351.
Jennings JJ, Mandaliya R, Nakshabandi A, Lewis JH. Hepatotoxicity induced by immune checkpoint inhibitors: a comprehensive review including current and alternative management strategies.Expert Opin Drug Metab Toxicol. 2019;15:231-244.


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No catches, no fine print just unconditional book loving for your children with their favourites saved to their own digital bookshelf.
New members get entered into our monthly draw to win £100 to spend in your local bookshop plus lots lots more...Find out more
Written by Penny Tassoni
Illustrated by Mel Four
Part of the Time to.... SeriesWrite A Review
Share the art of tidying up with your little one
Penny Tassoni, leading Early Years education consultant, author and trainer, presents a picture book with simple words and engaging full-colour illustrations by Mel Four that puts a positive spin on why tidying up can be part of the play! Time to Tidy Up helps young children build on their behaviour and routines when it comes to tidying up. It also includes a page of practical advice and tips for practitioners, carers and parents making it the perfect resource for supporting this essential self-care skill.
The Time to...is a series of clear and well-illustrated books for very young children to share with their parents and carers. The books are inclusive, embracing all elements of society and offer an instructive and supportive resource for those caring for pre-schoolers.
Playtime can involve a wealth of resources from toys and blocks to books and paint, but sometimes putting all of these items away can be a battle.
What a great resource - I need these books in my life. -- Kate Pankhurst - Author of the 'Fantastically Great Women' series
A highly recommended set of books to have in your Early Years setting or on the bookshelf at home. -- Kathy Brodie - Early Years professional, consultant and trainer
With positive language through the books, children will find them fun and likeable with joyful and inclusive illustrations to match. -- Rosalind Millam - Professional Association for Childcare and Early Years
I love these books and can't wait to read them with my two boys! -- Adrian Bethune - Author of 'Wellbeing in the Primary Classroom'
|Publication date:||3rd October 2019|
|Publisher:||Featherstone an imprint of Bloomsbury Publishing PLC|
|Suitable for:||Baby and Toddler, 3+ readers|
|Genres:||Personal Social Health Economic|
Penny Tassoni MBE is a well-known education consultant, author and trainer who specialises in the whole spectrum of learning and play. Penny has written over forty books, many of which are best sellers in the Early Years sector. Penny is a sought-after speaker both in the U.K. and internationally, having worked in Istanbul, China and Japan. In addition to training practitioners, Penny is President of PACEY (the Professional Association for Childcare and Early Years), which has a membership of 35,000 childminders and carers. She also works as a consultant to leading toy manufacturers.More About Penny Tassoni

domain: literature


text:
Smaller classes and a pathway from Vancouver Community College to SFU
VCC is now offering two new University Transfer certificate programs that will enable students to gain assured admission into second-year SFU applied science degree programs.
“By offering these courses, we will provide students in the Lower Mainland an opportunity to transfer seamlessly into second year at SFU,” says Dr. Andy Sellwood, department head, science, school of access, VCC.
The first-year University Transfer Engineering and Computer Science and Software Systems certificate programs provide students with the opportunity to explore options and demonstrate success at the first-year level of university studies. Students will gain transfer credits to the SFU Engineering Science, Computing Science or Software Systems degree programs.
Read More: Smaller classes and a pathway to SFU


Formerly occupied Africa north and south of the Sahara, east Africa, Africa south of the rainforest belt, and much of Asia minor. Now lives in East Africa and south of the Sahara.
Dry and sandy regions, generally in the open country
Very large, terrestrial birds (largest bird extant) with long necks and legs but small heads. They have wings but are flightless.
Males are larger than females, all have black and white feathers on the body. They have a bald crown, ringed with short, stiff, brown feathers. Bill is yellowish above, pink to red below.
Females are smaller and grayish-brown with pale feather edges. Neck is pale pinkish color to grayish-brown.
Diet in the Zoo: grain, hay, and alfalfa
Diet in the Wild: Mainly herbivorious, but also eats insects and some small vertibrates
May live up to 50 years both in and out of the wild
The population is a mixed society of flocks, families and individuals. In common grazing grounds, different flocks will peacefully co-exist but stay in their individual flocks. Families may often adopt chicks from another flock.
Normal walking speed is 2.5 mph, but they can reach speeds of 45 mph if alarmed. If cornered, they can kick their predator to defend themselves.
They love water and will take baths if given the opportunity. In order to escape detection, they may lie on the ground with their necks outstretched. They do not bury their head in the sand.
Three of the animals that commonly inhabit the savannah are eland, zebra and ostrich. Zebra and eland eat the grasses and shrubby plants. Ostriches eat the seeds of the plants and the insects and small invertebrates stirred up by the herding animals.
Together, these three animals comprise a "triple alliance" against predators: zebras have large, rounded ears that provide for excellent hearing, eland have a very acute sense of smell, and ostriches have legendary eyesight. Other mammals which inhabit the ecosystem include lion, leopard, cheetah, elephant, giraffe, rhinoceros, buffalo, wildebeest, gazelle and a number of other antelope species. Ostriches share the landscape with bustards, hornbills, ox-peckers and shrikes.
Ostriches were nearly wiped out in the 18th century due to the demand for feathers. By the middle of the 19th century, ostrich farms began to spread, and the population is secure.


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Medicine Overview of Rase 1 Sachet
Rase 1 Sachet is used in the treatment of diarrhoea
Headache, Rash, Itching.
Take this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. Empty the granules in a glass of water/milk, stir it and consume immediately. Rase 1 Sachet may be taken with or without food, but it is better to take it at a fixed time.
Rase 1 Sachet is a combination of two medicines: Racecadotril and Saccharomyces boulardii which reduce symptoms of diarrhoea in children. Racecadotril has an anti-secretory effect. It reduces the secretion of water and electrolytes from the intestine. This helps to reduce the amount of fluid loss from the body in diarrhoea. Saccharomyces boulardii is a live microorganism which restores the balance of good bacteria in the intestine that may get upset due to intestinal infections.
In Depth Information on Rase 1 Sachet
Rase 1 Sachet related warnings
Interaction with alcohol is unknown. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.
No information is available on the use of Rase 1 Sachet during lactation. Please consult your doctor.
Rase 1 Sachet does not usually affect your ability to drive.
Rase 1 Sachet should be used with caution in patients with kidney disease. Dose adjustment of Rase 1 Sachet may be needed. Please consult your doctor.
Use of Rase 1 Sachet should be avoided in children with underlying kidney disease.
Rase 1 Sachet should be used with caution in patients with liver disease. Dose adjustment of Rase 1 Sachet may be needed. Please consult your doctor.
One of the following vendor pharmacies will deliver Rase 1 Sachet: MPC, HMP, ESY, AYM, NTB, UMP, MAX, RPP, GTK, AAR, PLT, SGH, BIO, RSS, SYN, RHW, ABP, SJP, RSA, OWP, GBL, KHC, JVO, DAO, NAS, PPR, DPP, SLN, HTS, PNT, MLC, RWP, TOM, VNS, SWA, PEN, ADT, ENP, DVH, JSL, NWP, HBV, NXG, AYU, DYG, RKS, PRN, P2P, SCH, BHM, SBL, OLT, IPL, DLP, 9T9, SVS, SHP, CHP, TRP, PMA, PTI, HNP, WHL, DFP, MDO, OIP, JIV, RHL, PWN, SRG, CLT, BBS, ZEL, JVN, RUS, SHC, SDM, RDR, HEX, SAF, NSL, AAY, QTM, OHM, SGC, GPT, BDN, SSA, STA, MSD, DPL, MDH, GNC, EVP, DGN, ZVP, NNH, RJH, MAK, RPI, INC, HAT, EQN, USF, SHD, HSP, PVP, FGH, GPP, ARD, QLF, AMR, ATL, TFP, LCC, BLE, BHP, SVH, VRS, NVY, HPC, WSI, TNH, KMC, RDH, LHA, HZF, AGT, SPD, DHR, IAD, BAP, ZPR, ATP, NVL, SWP, SBA, NDP, HIP, GHR, ANT, BTM, GTC, BSN, HGI, THP, KHH, BMJ, MAM, EMB, EPS, VDH, BAL, MMS


The home is a central point of focus for much of our daily lives and it’s in New Zealand homes that one of the world’s newest manufacturing frontiers – nano technology is making a big difference.
The nanofibres that go into SETA ventilation filters are miniscule, yet one of the most effective ways of removing air borne nasties that lurk inside homes.
It’s the harnessing of SETA’s innovative green technology used exclusively in HRV’s ventilation systems that is helping keep almost 150,000 New Zealand homes healthy – along with the people and families who live in them.
Key to the health of a home is replacing stale indoor air with fresh filtered air. SETA filters are extremely effective at doing this because the ultra-thin nature of nanofibres, which are 500 times thinner than a human hair, meaning there is a greater surface area and therefore higher efficiency.
SETA has taken the filter’s effectiveness a step further by infusing them with natural anti-bacterial Manuka extracts.
The nanofibres in these filters can capture more than 90% of dust particles, spores, pollen, and bacteria (as small as 0.4 of a micron) that circulate throughout a home.
A ventilation system, run in conjunction with top quality insulation and heating (and cooling) solutions, will help dry out a house, and reduce mould and condensation which can lead to respiratory problems such as asthma and chronic allergy symptoms.
And a home that can do that has got to be good for all Kiwis.
Sadly this isn’t the case in many New Zealand homes. The proof is in the accelerating number of media and coroners reports that keep surfacing about the state of the country’s homes being to blame for ill health, suffering, and even most tragically fatalities.
Poor indoor living conditions in many New Zealand homes, brought on by cold temperatures, airborne nasties and substandard buildings, impacts on everything from health and well-being to everyday things such as a child’s learning capability at school and a person’s work output.
In the last two years HRV has conducted The State of Home Survey to gain insights into what issues are facing the public when it comes to their homes. The drive behind the survey is to help address the current state of New Zealand’s housing stock, the health of their occupants and to increase awareness around the importance of insulation, ventilation and heating solutions to create healthy homes.
One of the most striking differences in this year’s survey compared to last year was the increase in the number of people who have moved out of a home because it was cold – up from 20% in 2014 to 26% in 2015.
On the one hand, this increase shows a raised awareness about the importance of living in a healthy home, yet it also highlights that more needs to be done to get homes up to a safe and healthy standard.
Other key findings from this year’s survey include:
- 82% of homes experience condensation
- Just over a quarter would like to be living in a warmer, drier, healthier home in the next five years
- 55% of New Zealand households are affected by asthma and allergies
- 25% of those who suffer from asthma or allergies say they think their living arrangements aggravate their symptoms
The poor state of many New Zealand homes leads to gross inefficiencies when it comes to running a household. Occupants become sick, miss work and school, which impacts on productivity, earnings and education.
Results from this year’s survey found a third of NZers are concerned about the impact of a damp, cold or mouldy home on their family’s health and almost 40% have had between 2 and 5 sick days in the last 12 months.
The condition of our homes also leads to a huge amount of wastage in terms of energy and power.
However, on an everyday level, there are savings to be made with a combination of insulation and ventilation meaning heat sources run more efficiently which results in savings on monthly power bills, especially during winter.
A healthy home is, by definition, an energy efficient one.


text:
Synopses & Reviews
In Memory Eternal
, Sergei Kan combines anthropology and history, anecdote and theory to portray the encounter between the Tlingit Indians and the Russian Orthodox Church in Alaska in the late 1700s and to analyze the indigenous Orthodoxy that developed over the next 200 years.
Sergei Kan is professor of anthropology and Native American studies at Dartmouth College.
"[Provides] a vivid picture of the engagements between the actors who together contributed to transforming Tlingit culture: the different Tlingit families, the Russian traders, Orthodox and Presbyterian missionaries, Russian and U.S. settlers, and Tlingit women and men." -American Ethnologist
"This extraordinary book . . . is a model of historical anthropology." -American Historical Review

domain: history


text:
This past June, Cambridge University Press published The Handbook of Material Culture Studies, edited by Professors Lu Ann De Cunzo (Anthropology) and Catharine Dann Rober (Winterthur Program in American Material Culture), with contributions by additional University of Delaware faculty. This interdisciplinary book is sure to be a valuable resource for scholars of material culture. For more information, see the Cambridge University Press website and its description of the book below.
Material culture studies is an interdisciplinary field that examines the relationships between people and their things: the production, history, preservation, and interpretation of objects. It draws on theory and practice from disciplines in the social sciences and humanities, such as anthropology, archaeology, history, and museum studies. Written by leading international scholars, this Handbook provides a comprehensive view of developments, methodologies and theories. It is divided into five broad themes, embracing both classic and emerging areas of research in the field. Chapters outline transformative moments in material culture scholarship, and present research from around the world, focusing on multiple material and digital media that show the scope and breadth of this exciting field. Written in an easy-to-read style, it is essential reading for students, researchers and professionals with an interest in material culture.

domain: library


text:
Editor’s note: This is one in a series of reports about the potential health hazards to military personnel who had been deployed to areas with airborne toxins from burn pits, oil fires and desert sandstorms.
Combined with heat sometimes in excess of 120 degrees, the smell lingered — sometimes faint, sometimes overwhelmingly pungent. Always, the smell meant the fires of the burn pits were destroying everything from human waste to batteries.
Depending on a service member’s proximity to the pit, the smell was accompanied by smoke: Sometimes a haze in the air, seemingly a mirage, other times a thick fog.
Millions of service members fighting in areas of Iraq and Afghanistan were subjected to these conditions, because they were ordered to burn everything so it would not fall into enemy hands or impact the environment.
In the three counties surrounding Fort Hood, nearly 60,000 veterans could have been exposed to the health-altering chemicals contained in smoke from those burn pits during deployments to Southwest Asia since the beginning of the Gulf War Era conflict in 1990, according to the Texas Veterans Commission. That does not include the thousands of active duty troops currently stationed at Fort Hood who have been exposed.
Sources of toxins
Burn pits toxins were not the only airborne hazards in the Southwest Asia theater of operations. Heavy black smoke from burning oil fields and the brown-out conditions of frequent sandstorms carried hazards capable of bringing long-term health problems to those exposed.
Yet, of those nearly 60,000 veterans from the Fort Hood area potentially exposed to these toxins, barely 4,500 veterans living within 50 miles of the Temple VA hospital have signed up for the Department of Veterans Affairs’ Airborne Hazards and Open Burn Pit Registry, said Vincent Mitchell, program analyst and registry manager for the VA.
The registry, mandated by Congress, became available to veterans of the Gulf War Era in June 2014, said Dr. Patricia Hastings, deputy chief consultant for the VA’s Post Deployment Health Services in Washington, D.C. The Gulf War Era encompasses all operations in the Southwest Asia theater since August 1990, which includes the wars in Afghanistan and Iraq after Sept. 11, 2001.
Signing up for the registry gives veterans and service members who might have been exposed to toxic chemicals information on what research is being done and the opportunity to get an exam.
“The registry allows us to have a mailing list of sorts to encourage people to have the optional airborne hazards medical exam. It also will allow us in the future to build cohorts to look at studies for health outcomes with regard to their service and proximity to a burn pit, if that occurred,” said Hastings, a retired Army colonel.
Nationally, approximately 3.7 million veterans have been impacted by exposure to burn pits, oil well fires and sandstorms during deployments to places that include Iraq, Afghanistan, Kuwait and Djibouti in the Horn of Africa, Hastings said. This includes current conflicts as well as Operations Desert Shield and Desert Storm.
The U.S. military had 250 burn pit sites in Iraq and Afghanistan alone since the beginning of the War on Terror, according to www.vetshq.com.
“The goal of the registry is three-fold — one is information to the veterans. Like I said, it’s sort of a mailing list if there is something we want to notify a large number of people, we can do mailings to people in our registry,” she said. “We also use it to get them to take the optional medical exam. And then we are looking at it for research that can be done and being able to tie the registry and exposures with health outcomes.”
So far, no illnesses have been linked to exposure to airborne hazards and burn pits, the doctor added. But the VA and the National Academy of Medicine continue to research possible links.
A June 2015 report on the registry done by the VA has found commonalities among participants seen by a medical provider after deployments. They included reported diagnoses of chronic obstructive pulmonary disease (COPD), chronic bronchitism, emphysema and asthma. A small percentage reported constrictive bronchiolitis. Other illnesses reported included cardiovascular issues, insomnia, neurological problems and immune system problems.
A 2011 study by the Institute of Medicine of the National Academies found that between 100 and 200 tons of waste was disposed of each day just at Joint Base Balad in Iraq, according to www.vetshq.com. The study at Joint Base Balad found that five or more chemicals contained within the smoke from the burn pits were associated with health effects such as liver and kidney problems; stomach, respiratory and skin cancers; and reproductive issues.
With many of those health issues, people afflicted require a heavy regimen of medication and frequent medical procedures such as dialysis, seriously affecting their quality of life.
Health hazards have been tied to other conflicts and the VA has registries for them also.
“For example, the Vietnam conflict — there are some health outcomes that are tied with exposure to Agent Orange,” Hastings said. “We haven’t found that (with the burn pits) yet, but we are looking at it continuously because the health of the service members and health of veterans is exceedingly important.
“(The airborne hazards and open burn pit registry is) really a long-term study. There is a latency for a lot of diseases. For example, we would not know of any cancers associated for 10, 20, 30 or more years because there is a latency for some disease processes.”
Nationally, more than 141,000 veterans and active service members have signed up for this particular Gulf War Era registry, but only 5.2 percent who register have opted to take the exam, Hastings said.
“I think in a lot of cases the reason for this is, if they do not have an illness and are feeling OK, then they don’t feel compelled to come in for the burn pit exam,” she said. “But we are trying to encourage (taking the exam).”
The health exam can be done multiple times over the years, she added. “And they are doing it for other veterans — we’ll be tying this to health outcomes over the course of decades, similar to what we’ve done with Agent Orange. Their volunteering to do this helps other soldiers, and it helps other veterans.”
The use of burn pits was a common waste disposal practice at military sites outside of the U.S. such as in Iraq and Afghanistan, according to a fact sheet put out by the VA. Smoke and other emissions from these pits contained an unknown mixture of substances that may have short and long-term health effects, especially for individuals who were exposed for longer periods or those with pre-existing conditions such as asthma or other lung or heart conditions.
“The things burned that are concerning are batteries, other things that could be recycled. There is also the issue of the burning oil wells,” Hastings said. “We also have the issue of some of the different munitions that were burned. It’s a very different environment with regards to the arid, desert environment and the many things that were there, as well as the dust and sand.”
According to a September 2016 report by the Government Accountability Office to Congress, DOD established guidance to meet applicable legislative requirements through the issuance of DOD Instruction 4715.19, which covers how and when the use of open burn pits may be used during overseas contingency operations. However, DOD has not fully assessed the health risks associated with burn pits. DOD officials told GAO that there are short-term effects from being exposed to toxins, but DOD does not have enough data to confirm whether direct exposure to burn pits causes long-term health issues.
The VA’s registry will help DOD gather that data, Hastings said. The registry includes a rather long questionnaire and will take between 40 and 50 minutes to complete, depending on the number of deployments. Part of that is due to asking questions on hobbies, jobs and places the veteran has lived.
“Our over-riding priority is burn pits, but say you decided you were a shooting enthusiast and you make your own bullets — there is exposure to lead,” Hastings said. “So we do ask about hobbies, we ask about jobs.”
Signing up for the registry does not sign a veteran into the VA health care system, however, she said.
Veterans are encouraged to register for VA healthcare for treatment.
While the exams will be free and will help veterans possibly exposed to monitor their personal health, any illnesses they may develop tied to the airborne hazards and open burn pits cannot be treated by the VA unless the veterans sign up separately for VA health care.
“The (registry) exam is not meant for ongoing care — it is an exam to determine health status, so if they want to get care they have to register with the VA,” said Hastings, who served 30 years on active duty in the Army. “I don’t think it’s that onerous — the just have to prove they served, were discharged honorably. I mean, many of us do that.”
Michelle Sivak, a spokesperson for the Department of VA headquarters, said that one of the benefits of signing into the VA health care system is that while most care for veterans can be taken care of at the local VA, if they have an unusual case — something that is hard to diagnose or put together a treatment plan for — there is another level of care offered by the VA to put together an exam and a treatment plan.
After a veteran has exhausted the appropriate specialty consults and the diagnostic capabilities at the local VA facility, a referral for an evaluation at the War Related Illness and Injury Study Center may be appropriate, according to a VA fact sheet. That center provides clinical evaluations for veterans with the most complex, difficult-to-diagnose or medically unexplained health concerns related to airborne hazards or other deployment-related exposures.
“This is an important subject, something the VA is working on very diligently,” Hastings said. “I encourage people to come into the registry and get the optional health exam; the things this registry will provide for research are important.”
For more information on the registry, visit www.publichealth.va.gov/exposures/burnpits/registry.asp.
Reporter David A. Bryant is an Army veteran who had been deployed to Iraq, Kuwait and Djibouti.
firstname.lastname@example.org | 254-501-7554


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This period starts when you get to know a person’s name and ends when you start dating. She also adds that it’s important to figure out how long you’re willing to let the talking stage go on for, and how long you’re willing to wait for a reply.
It all depends on you, how you view dating, and your connection with whoever it is you’re talking to. The talking stage may seem long and drawn out, and you may just want to cut to the chase and get married, but it’s so important you take your time and really make sure you look out for those red flags. This philippino brides can be confused with dating as it is obvious but the talking stage is the period before you actually start dating.
- In fact, as the dating scene has changed dramatically over the years it has been a part of it in some form.
- A wink across the room is simultaneously ambiguous and suggestive, which means you’ll leave a guy reeling for answers before you even start talking to him.
- Men are often pleasantly surprised and even impressed when women take the initiative to start a conversation.
- When you have talks with someone, you don’t set too high expectations.
Ending the night can get awkward even if the date is seemingly going well, too. Try gauging their calendar by asking what they’re up to next weekend and then slyly suggesting that you’ll be free on Friday. Or, if you’d like to be more direct, mention a restaurant, bar, or experience you’ve been wanting to try, and if they show interest, ask if they’d like to go with you. It may seem scary, but the worst they can do is say no.
For some people, the talking stage goes on for far too long. You might want to move to the dating phase, but the other person might be dragging their feet. People with avoidant attachment personalities have a hard time with emotional intimacy. The talking stage puts a barrier between people, usually via phones. It allows the avoidant person to keep their emotional distance. It is the place between knowing you’re dating someone you’re interested in, and just meeting them.
Maybe you want to date and be exclusive, or you’re ready to make the relationship official. In the talking stage, you get to know someone without an official label. You and your crush are texting and talking on the phone every day, but steering clear of defining the relationship. It can sound a lot like dating, but you and your crush are simply testing the relationship waters and learning about each other. Essentially, the talking stage should start after first being introduced or meeting. On a dating app, it’s when you’ve gone from the app to texting. The talking stage, to many, is also fair game for ghosting.
How to Start a Conversation With a Guy
The soundtracks to our lives say a lot about our people and what inspires us. Music is a super-easy way to connect with a guy, especially if you can find mutual musical interests. Even if you know nothing about his hobby, showing genuine interest with follow-up questions and listening skills (head nods, “mmm-hmm,” and eye contact) will make him feel important. While you probably shouldn’t gush over a guy, a simple “I like your shoes” or “you have a nice beard” are great ways to flatter him and get the conversation rolling. Before you walk up to a guy to initiate a conversation, send him an easygoing smile with both corners of your mouth raised evenly and your teeth slightly showing. Prolonged eye contact triggers oxytocin release in the brain, which links to increased attraction and arousal, even in strangers. You can use this to your advantage when initiating a conversation with a guy you’re interested in.
” I hear you cry; it’s that awkward period where you’re stuck in a limbo of getting to know someone while catching deep feelings for them…but you’re not sure if they like you back… Or if they’re having several talking stages with different people. Of course, romantic relationships without a title aren’t exactly a new thing. Although most people think talking every day when they start dating is a brilliant idea, it does not imply the relationship is on the right path. Talking too much may only help if you have made a solid connection in real life. From social media etiquette to whether or not it’s still okay to see other people, the rules of the talking stage are different depending on who you ask.
How do you know if the talking stage is going well?
When you spend time together in person, you gain valuable insights into their personality, manners, and sense of humor. You can better discern if the friendship has ignited the spark of romance. Spend time assessing and evaluating the level of communication you have with any potential partner to determine if they are the right fit for you. Except for the fact that the talking stage doesn’t necessarily mean you’re dating. Some people have had an underlying passion to travel the world in the back of their head their entire life, and others prefer to stay near family and friends and build their forever home there. Whichever it may be, find out your date’s preference.
But in real life, the talking stages can end painfully. If you feel your partner on a deeper level and are interested in dating, the end of communication may break your heart. With all that said, this uncertain dating stage is nothing new. In fact, as the dating scene has changed dramatically over the years it has been a part of it in some form. And today we have an amalgamation of them all — commitment is scary, sex is celebrated and figuring out relationships has never been more difficult. And this is all while most of us have the same end goal of being loved. This article was co-authored by John Keegan and by wikiHow staff writer, Devin McSween.
Tell them that you’ve been meaning to try out that new coffee shop or see the latest blockbuster. If they say that they’ve been meaning to as well, ask them if they want to join you. Follow us on Instagram Facebook Twitter Pinterest and we promise, we’ll be your lucky charm to a beautiful love life. This is usually the time you also get to know each other’s dealbreakers.
They could be talking to a lot of other people at the same time they are talking to you. For others, you could be in this stage while talking to other people. Maybe after two dates, you realize they aren’t for you and then the talking stage ends. You could be talking to someone else and after a month realize you like them. This can then go on until you express your feelings and intentions. Maybe before even meeting them, you say how surprised you are by how fast you’re catching feelings. Maybe after the first date you know you’re interested, and don’t want to talk to anyone else, and you’re on the same page.

domain: psychology


The objective is to help people efficiently resolve their traffic ticket without actually going to court.
Ron Sokol is a Manhattan Beach attorney who writes a question-and answer column on legal issues
The rationale is to protect public health by discouraging dangerously concentrated cannabis.
Defamation in writing is known as libel. If you can determine who posted the items, you can sue.
The Federal Whistle Protection Act was instituted 1989 to protect the rights of employees who report wrongdoing in the government.
California Penal Code Section 597 makes it a crime to mistreat animals in a number of ways, such as maliciously and intentionally maiming, torturing, wounding, mutilating or killing an animal.
It is not that public execution is illegal so much as there is one very pragmatic reason why executions are not carried out in public: the crowds become unmanageable.
As of early April, theme parks in California can reopen, subject to various conditions.
While most taxpayers are not audited, research indicates there are "red flags" to avoid.
If the outcome is bad and unexpected, you have to find a way to roll with it, to seek to remain deliberate, and to take the next prudent steps.
Car pool lanes legally are designated as "High Occupancy Vehicle Lanes." The number of occupants required to properly be in the lane should be indicated by posted signs.


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As Professor Sir William James pointed out there is more than one imaginable functional dependence of the mind and brain relationship. Now the production theory is more simpler than the transmission theory which is why most neuroscientists are in favor of it however that does not mean it is the correct one.
Evidence that fits into the Transmission theory of the mind and brain for example are
1. The reality of psi has been experimentally established beyond any reasonable doubt, and any viable theory of human personality will have to accommodate this fact.
2. Evidence of post-mortem survival. The amount and quality of such evidence is impressive, although it is little known outside the psi research community. In suggesting that some aspects of mind including procedural and declarative memories may persist independently of the physical organism, it presents the most stark and direct challenge conceivable to prevailing views. Serious and able students of this evidence remain divided about its proper interpretation, but the subject clearly merits intense further investigation.
3. Mystical experience. Previous workers such as William James, Aldous Huxley, and Walter Stace have demonstrated convincingly that there is a fundamental commonality to these powerful experiences which unites them as a class throughout recorded history and across diverse religious cultures. What has not been so clearly recognized is that their strong truth claims receive empirical support from the verifiable effects such experiences produce in the lives of those who have them. These effects may include, for example, incursions of psi abilities, increases in reading speed and other readily-measured cognitive skills, etc. Another relevant feature new since James’ time is that we now have a lot of information about transformative practices, and a large cadre of active practitioners, which should make the phenomena more accessible to study.
4. Near-Death Experiences. At least some such experiences appear to occur under physiological conditions which most neuroscientists would expect to be incapable of supporting any kind of organized mental activity, let alone the complex and powerful experiences that sometimes occur. A recent example is a case reported by Michael Sabom, involving an NDE that occurred during a drastic medical procedure for repair of a cerebral aneurysm (see Bruce Greyson’s presentation). The increasing use of multidimensional physiological monitoring in major surgical procedures can be expected to make additional cases of this important type available for detailed study.
5. Pschyedelic experiences. Huxley’s interpretation of such experiences as resulting from a suspension of the normal "filtering" action imposed by the brain should be revisited in light of more detailed information about the physiological modes of action of specific agents. Ketamine, for example, is a dissociative anesthetic, and a powerful entheogen at subanesthetic doses. It selectively disrupts the NMDA receptor system of the upper cortical layers, which plays a major role in tangential interactions among cortical areas, and yet such interactions are widely presumed to provide the normal physiological basis for organized perceptual and cognitive experience.
6. Multiple personality disorder and trance mediumship. Many unusual phenomena have been reported in such cases which appear to strain conventional theories of overall brain function. For example, in co-consciousness a personality B may be simultaneously aware of its own experience and that of personality A, but not vice-versa. Similarly, when an MPD subject stands in front of a mirror, different "alter" personalities may simultaneously have radically divergent visual experiences, e.g. seeing a young blond female vs. an old dark-haired male. In the case of "Old Stump", described by James, a background personality was apparently unaffected by an illness that produced concurrent delirium in the surface personality. The trance medium Mrs. Piper, discovered by William James, occasionally carried on interactions with three sitters at once, speaking to one and writing messages to the other two using both hands simultaneously. All such cases, conventionally viewed, seem to involve simultaneous engagement of major brain systems in different and potentially incompatible ways.
7. Calculating prodigies, especially "idiot savants". From a neurocomputational perspective, the only way to get greater logical and arithmetic precision out of individually unreliable elements (the neurons) is to use more of them, and the few existing studies of these fascinating phenomena suggest that savants must either be using virtually every neuron they have, or doing their calculations in some radically different way. Functional neuroimaging studies might quickly resolve this.
8. Intentionality, meaning, and the felt unity of conscious experience. The "aboutness" of our mental life, the fact that our thoughts, images, feelings, memories, … are experienced as being directed by ourselves, operating as unitary agents, toward external or internal states of affairs, remains a fundamental mystery despite recent discussions of the "binding problem" etc. These properties are fully present even in the simplest acts of perception, as recognized already by William McDougall in his 1911 book Body and Mind. Recent work on cross-modal interactions in perception has belied earlier characterizations of perception as a bottom-up calculation from the patterns of activity appearing at the receptors, and emphasized the role of top-down controls. But where is the "top", precisely? Philosopher Roland Puccetti has recently updated arguments originally advanced by James’ contemporary F. Brentano to the effect that this property of intentionality lies at the heart of the mind, and that it cannot conceivably arise in ANY physical system as presently understood.
5 days ago


Wed 24 October 2018 | 6:30 pm - 11:00 pm
Live Park Rishon - Live Park in Rishon, Rishon Letzion,
A wonderful time goes on sleep – and the opening of this year it will celebrate big time!
After a phenomenal evening at the Raanana amphitheater with Berry Sakharof, out of sleep to meet two giants, singles, The cornerstones of Israeli music: Ehud Banai and Evitar Banai.
From sleep, Ehud Banai and Evitar Banai are undoubtedly different but complementary colors, a combination that promises a lot of magic. As proof of this, the immortal song “Night Train to Cairo” is the fruit of this exact family connection. With Ehud Banai’s cooperation in the lyrics, Shlomi Bracha’s melody – this is a song that symbolizes a time of joy and anthem in Israeli music.
From Sleep Comes With the Magnificent Orchestra: Choosing the
Senior viola player in the country, Galia Hai, alongside guitarist Zohar Ginsburg (Asaf Avidan), talented music producer Eitan Raz plays electronic drums and percussion, and of course, the three top performers Yair Slutsky (Shalom Hanoch), Shlomi Alon (Snake Fish) Frankenstein).


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Kyocera Corporation has announced changes in its manufacturing operations starting April 1. Particularly, the changes involved its operations in Tokyo Chigase facility and its two facilities in Japan’s Shiga prefecture.
Moreover, the company made alignments of its manufacturing operations in these areas in a bid to enhance operational efficiencies.
In Tokyo, the company has moved the manufacturing operations of its optical components business from the Tokyo Chigase Facility in Ome to the Tokyo Hamura Facility in Hamura-shi both in Tokyo. Accordingly, the decision aims to enhance operational efficiency in production. Kyocera has closed the Tokyo Chigase facility immediately after the completion of the consolidation.
The Tokyo Hamura Facility develops and produces components for various industries. Specifically, it makes optical components for industrial machinery, automotive applications, and medical devices for lenses. Furthermore, it employs about 130 employees.
Earlier, Kyocera also announced the integration of its current Shiga Yohkaichi Plant in Hebimizo-cho and its Shiga Gamo Plant in Higashiomi, both in Shiga. The company now calls the combined facility Shiga Higashiomi Plant. The integrated facilities manufacture fine ceramic components and semiconductor components. In addition, it also produces electronic components, industrial tools, and medical products.
Accordingly, Kyocera implemented the integration of these two Shiga facilities in a bid to enhance operational efficiency. The integrated plants began operations on April 1.
The total combined area of the two sites is approximately 442,000sq.m. Moreover, the two facilities employ approximately 3,400 employees.
-2 April 2024-

domain: economics


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Price setting behavior in an open economy and the determination of Finnish foreign trade prices
This paper investigates price setting of internationally traded goods. We develop a theoretical model that incorporates sticky prices in the currency of both the buyer (local currency pricing) and seller (producer currency pricing). The nature of price setting is thus forward looking and the exchange rate effect depends on the relative share of local currency and producer currency pricing firms in the economy. The model is estimated with Finnish foreign trade price data for the period 1980–1998. The estimation results seem to support the model. The estimated share of local currency pricing is 40 percent in the export sector and 60 percent in the import sector implying that there is limited pass-through from exchange rate to destination-country prices in both sectors.
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