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The blaring headline in today's New York Times makes it official:
Biggest Liberal SuperPac to Fund Possible Clinton Bid.
If you think they got it back-asswards, then you got it right. It appears that candidates don't even have to formally announce their own candidacies any more. The Big Money is doing it for them. Since Big Money is effectively running the country already, then it's Big Humanoid Money that's officially asking for your useless vote. How precious. From the Times:
The move marks perhaps the earliest-ever start to big-dollar fund-raising in support of a nonincumbent presidential candidate, providing a fund-raising portal for wealthy Clinton supporters eager to help her White House prospects — and to the legions of others eager to ingratiate themselves with Mrs. Clinton and her inner circle.
Jim Messina, Mr. Obama’s campaign manager in 2012, who has forged close ties with many Democratic donors, will serve as co-chairman of the revamped super PAC and an affiliated nonprofit, along with Jennifer M. Granholm, the former governor of Michigan who is among the most persistent voices calling for Mrs. Clinton to enter the 2016 race.
That Jim Messina sure is one busy multi-tasker, having just hired himself out to also advise Britain's arch-conservative austerian P.M., David Cameron. And that's on top of running the Obama legacy-burnishing retirement account known as Organizing for Action. So, the fact that Messina is now also in charge of what amounts to a phantom Hillary campaign does tend to lend credence to the theory that global rule in the wake of a transnational corporate coup is already pretty much a done deal. Plutocrats Without Borders, if you will.
Or as Barack Obama himself would probably explain: "There are no red countries, there are no blue countries. There is only the United Oligarchy of the World United Against You, the Citizen Terrorists. Nations, schmations."
And speaking of Cameron, and police states and corporate rule, British police officials are so paranoid about possible protests against government austerity measures that they're seeking permission to use water cannons against unruly starving people. The Guardian explains the need for anti-citizen weaponry:
It (the police report) adds that although the debate on water cannon was sparked by the riots in London in 2011, there was also serious disorder in many major cities and towns "of an intensity and scale where water cannon potentially could have offered an operational advantage to public order commanders".
It also discloses that the water within the water cannon tank will have to kept at 5C to "prevent the onset of medical conditions associated with the shock of being exposed to cold water".So, it's heartening to know that the police state will be careful not to actually kill you as it shocks and drowns you. It sounds very similar to the enhanced interrogation technique known as water-boarding, conducted only under the humane supervision of qualified medical personnel.
Coming soon to a depleted food bank near you:
But am I digressing here, or what? From election-buying Plutocrats, to Hillary, to Obama, to Messina, to Cameron to.... police state water cannons? Nah. It's no digression at all. Everything's connected. It looks something like this:
Speaking of interconnectedness, here's my response to Gail Collins's very funny column about the Pope meeting the President next month, and how Republicans' heads are exploding from the populism craze, the American embassy in the Vatican being moved, and other insults:
Could it finally be Karma time for the GOP and the wealthy patrons keeping it on life support? A populist Pope not only debunks austerity, he has the gall to show up (by proxy) at the annual Davos confab to remind the partying plutocrats to share the wealth. Are you listening, Ken Langone and Paul Ryan?
As if the Pope needed help, Oxfam came out with a stunning new report showing that the 85 richest people in the world have more wealth than half the entire planet. So share it, already!
And as Davos opened, the rich people left behind in the Upper East Side were shocked to discover accumulating snowflakes on their streets. A Twitter eruption ensued, the petulance of the unplowed elites broadcast to the world. One peevish missive published in Rupert Murdoch's anti-Pope/anti-De Blasio NY Post was, appropriately enough, from the author (Molly Jong-Fast) of "The Social Climber's Handbook."
And then "MoBo" (the former Virginia governor and his wife) were indicted for criminal social-climbing, a k a grifting. Sensing an opening, Gov. Cuomo formally announced on the radio that homophobes aren't welcome in New York. And poor Cardinal Dolan, no doubt exhausted from his full-time job of assuring rich grifters that God loves them too, now has to go back on TV to yell at Cuomo and defend homophobes.
And meanwhile, Chris Christie is still melting down like a malevolent Frosty the Snowman.
And no, it's not a sin to indulge in a little Schadenfreude.And here's the one I wrote to Charles Blow about how he learned to love books as a child:
I was in second grade when I picked up L. Frank Baum's "Wonderful Wizard of Oz" and discovered a feast, amazed that the book was so much more engrossing than the movie version I'd just seen on TV. Books have been a constant presence in my life ever since. When I had children of my own, I discovered the joy of reading both old favorites and new classics out loud to them at bedtime.
I feel sorry for people who don't read. Maybe they just prefer TV and movies, maybe they're tired working too many hours, maybe their municipal libraries have reduced hours or closed altogether due to the epidemic of cruel austerity. It's probably a whole combination of things.
The ongoing assault on public education certainly isn't helping. Teaching to the test not only does not inculcate a love of reading for the pure pleasure of it, it probably discourages reading. You can't blame kids for wanting fresh air and entertainment after a long day of Drill Baby Drill. There is way too much emphasis on preparing children to be good little technocratic consumers for those low-paying jobs of the future.
Reading leads to independent thought and the questioning of authority -- a dangerous thing in a rising plutocracy whose survival depends on keeping citizens compliant and uncreative. When was the last time you heard a politician espousing more instruction in literature, the humanities, and the arts?
Oh, and in some places, they've even banned Oz because of its "godlessness."And a reader named "Alierius" remarked, "My mother had a collection of the Oz books and wow, some of them are seriously weird, LSD trip weird, like when the Tin Woodsman meets his 'meat' head, still in the cupboard of the tinsmith who made him. I have them now, and my daughter and I will read them together, in a few years..."
Ah, hope is not lost. As long as future generations can still read about the Tin Woodman's decapitated head in the cupboard, we can survive any onslaught, banding together in solidarity against SuperStorms, SuperPacs and SuperSoakers.
Meanwhile, though, we open up our cupboards and get assaulted with this New York Times Magazine cover:
Too Tin Woodman-creepy for you? Then do check out these alternatives at Buzzfeed.


No, no, not Steve Jobs but an even higher entity smiling upon the company. As I hope to show, Apple’s hard work years ago is now about to pay huge unexpected dividends on the iPhone. When the iPhone first came out of Steve Jobs’ quasi-divine hands in January 2007, it was a hack, the result of clever handcrafting by Apple engineers, a crazed last-minute rush to the show deadline. As such, it lacked the basics of what we call a platform, an industry term of art – or BS. Here, a platform means a combination software, or hardware, or both on which software developers build applications. A platform requires documentation, where the building blocks are, what they do, how to use them. The platform also comes with tools, software to build and test the applications. Last but not least, a platform implies some stability, meaning it works often enough, and it’s predictable, it doesn’t take brutal turns that undo the work of developers.
Early 2007, the iPhone had none of these attributes. So, Steve resorted to proven industry maneuver: If you can’t fix it, feature it. No need for “native” (meaning running on the iPhone itself) applications. This is the New World of Web 2.0, bleated the propagandastaffel. Use the iPhone’s browser (the best in the business, it helped immensely) to run server-based applications. No need to download anything, centralized maintenance, easy updates… The faithful heretics would have none of that and a new game started. One week the hackers managed to break Apple’s barriers preventing the installation of native applications. A few days later Apple issued an update to the iPhone firmware that broke the hacks.
Let’s pause for a lemma, a building block in the story: from day one, the iPhone had something no competitor had: iTunes. Apple made having an iTunes account a sine qua non requirement for using an iPhone. For downloading songs and movies, just like its younger brother the iPod? That and more. With iTunes you backup your iPhone, you bring it back to “factory settings”, helpful if a hack “bricked” it, meaning if it became as lively of a brick, you install software updates, most of which defeated the impudent hacks.
Moving forward, the pressure was building: Apple made a very smart move by using a trimmed down version of OS X (the Mac’s software… platform) as the software engine for the iPhone. We know and love OS X, said the developers. Mr. Jobs, tear down that wall! It now looks like Google’s Android helped Dear Leader make up his mind. Rumors were mounting: RSN (Real Soon, Now), Google would announce a free, open-source platform for smartphones. Just as Steve smartly turned around and touted Intel processors after years of expounding the superior PowerPC architecture, on October 17th, 2007, he stood up and announced the SDK (Software Development Kit) for the iPhone. Availability by the end of February 2008.
The belief in Providence benignly smiling on Apple now comes in. In 2001, Apple sweated the servers, the legal agreements with publishers, the one-click payment system, the client software on PC and Mac. All this to create the still-unequaled iTunes experience. Now, one bright 2007 morning, they have an epiphany: Songs are zeroes and ones. One click and they land in a bin, a directory in the iPhone. But applications are also strings of zeroes and ones. If we put up iPhone applications in the iTunes store, they land in a different bin inside the iPhone but the one-click purchase and download is the same. Halleluiah! All the work to build the iTunes business now pays off for the applications. We must be The Chosen Ones. This is no small detail. Today, if you’re an independent software developer, writing good code is the easy part. The Evil S&M, Sales and Marketing, await you. Shelf space, physical or on the Web, is very expensive. Setting up download and payment systems isn’t for the faint of wallet either. With the iPhone, Apple removes (most of) these hurdles. All you have to do is write good code.
Picture the young developer still living in his mother’s basement, he sells 50,000 copies of his work for $10, the price of an iTunes album. Apple keeps $3, he gets $7. Times 50,000, he makes $350,000 and can now pay rent to his mother and buy her a car. (For perspective, the current forecast is for between 30 and 45 million iPhones sold by the end of 2009.) Picture also the competition. No one else has such a well-oiled, widely known system to add applications to a smartphone as Itunes. (Google says they will eventually offer one for Android.) This is a billion dollars business. Actually, $1.2 billion in 2009, according to Gene Munster a Piper Jaffray analyst. (For a healthy counterpoint, see the snarky comments on TechCrunch.) Regardless, the arrival of native applications on the iPhone is a big event, one made possible by an unintended – and rather amusing – consequence of the iTunes music distribution system. How will this be written up in books and Harvard Business School case studies? –JLG


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Massachusetts health officials have joined others in a letter urging the FDA to get rid of a policy that effectively bars gay and bisexual men, as well as other queer people, from donating blood , the Boston Herald reported Monday.
The letter comes as the country faces its worst blood shortage in a decade, the newspaper wrote.
Health officials signed a letter to the FDA commissioner to rescind its 90-day blood donor deferral policy for men who have sex with men, the Herald reported.
This policy dates back to the time of the AIDS epidemic and was once even more restrictive, according to the Human Rights Campaign.
Originally, it prohibited men who have sex with men from donating blood. Then, in 2015, they were banned from donating blood within a year of having sex with another man. Since 2020, it has prohibited them from donating within 90 days of having sex with another man.
“There is no credible evidence that the 90-day MSM (men who have sex with men) blood donation deferment period improves the security of the country’s blood donation supply,” they said. writes North Carolina health officials to FDA Commissioner Robert Califf.
“And therefore, the continuation of this policy only serves to further stigmatize an already marginalized demographic and unnecessarily restrict the eligible donor population during a time of extraordinary need in the United States. The current policy is ineffective, unnecessary, and discriminatory. .”
Massachusetts health officials who joined the letter include Marylou Sudders, secretary of the Massachusetts Executive Office of Health and Human Services, and Massachusetts Department of Public Health Commissioner Margret Cooke, the Herald reported.
Other states supporting North Carolina’s letter were Connecticut, New York, California, Oregon, Nevada, Minnesota and Kentucky, Herald reported. The director of the DC Department of Health also signed off.
“The FDA requires that all blood donations undergo nucleic acid testing for HIV, a test that can detect HIV within two weeks of infection,” the letter states.
“Therefore, the risk of HIV-infected blood entering donation pools is negligible,” they added. “This diagnostic screening should be combined with an individual risk-based assessment based on our solid knowledge of how HIV is transmitted, and not applied in a discriminatory way to an entire group of individuals.”
The American Red Cross has also expressed support for the end of the policy.
the Herald reported that the American Medical Association has also urged the FDA to remove its 90-day blood donor deferral policy for men who have sex with men.
Stay up to date on all the latest news from Boston.com

domain: medical


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PPheromone lure of Cosmopolites sordidus (Banana Weevil)
Egg:The white, sausage-shaped eggs are about 2 mm long. They are deposited singly in cavities chewed by the adult females in the corm or pseudo stem at ground level or between leaf sheath scars on the crown of the banana corm. They are difficult to detect in the field because they are often hidden by congealed sap produced by the banana plant after the cavity is created. Egg laying also occurs in the form of fallen plants. Eggs hatch in 5 to 7 days. .
Larvae: The stout, creamy white, legless grubs have reddish-brown heads and fleshy white bodies. When mature they are about 12 mm long. The grubs are normally found in the pseudo stems up to 2 feet above the ground. Development is completed in 15 to 20 days. The eighth abdominal segment of the larva bears a large spiracle, the remaining segments bearing small spiracles; the last two segments appear truncated, being fused together to form a plate-like structure.
Pupae: Grubs pupate within chambers that are usually close to the surface of the corms. Pupae are white and about 12 mm long. No cocoon is formed. Pupal development is completed in about 8 days. The pupa has an irregular appearance, with the developing wings and limbs being discernable through the pupal case.
Adults: The adult is about 11 mm in length and has a glossy grayish-black or dark brown appearance. The tibia of each of the limbs bears an accessory hook-like claw with which the insect clings to plants. The hard-shelled weevil is has a long snout. Newly emerged weevils are reddish brown before turning black. Female lay an average of 1 egg a day during their life span. Adults are reported to live for as long as 2 years. They are capable of surviving for extended periods without food.
Injury is caused by grubs (larvae), which tunnel through the corms. Tunnels are circular in cross section, become wider as the grub grows and are filled with dark-colored debris. Extensive feeding damage by grubs results in root destruction, slowed plant growth, reduced fruit production, and, sometimes, toppled plants. The tunneling by the grubs makes the corms susceptible to invasion by secondary decay organisms. Reduced production and growth of suckers occurs when parent plants are heavily damaged. Affected sucker plants can be recognized by their dull, yellowish-green withered leaves.
Trap to be use: Bucket Trap
Number of traps per Acre: 1 to 2
Life of Lure: 90 Days

domain: agronomy


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The year 2014 was a year that Adaora Okoli will never forget any time soonest. It was the year that changed her life forever. A patient suffering from Ebola has checked into the hospital where she was working and in the process of treating the patient, she got infected with the deadly disease.
She did not know if she would live or die. “You don’t know if it’s going to end with your death,” she said.
But as luck will have it, she survived.
Ever since the unexpected turn of things, she has dedicated her life to the research, treatment, and prevention of future epidemics, studying at the Tulane School of Public Health and Tropical Medicine.
On Thursday, she was named as one of Bill Gates‘ 5 “Heroes in the Field.”
Dr Adaora Okoli was also featured on TIME magazine, where she shared her story to the world.
Watch the video of her story below:

domain: news


text: * It is made of high-quality wood, mechanically engraved, with exquisite details, safe and burr-free. * Multi-layer carpentry, each layer is dyed in a different color. It has been carefully crafted and has an eye-catching and elegant appearance. High-quality home decoration. If you are looking for a natural decoration idea for your living room or bedroom, this decorative wooden display stand will be your best choice.

domain: artistic


(Bloomberg) — An impressive afternoon rebound in equities failed to quell a sense among professional investors that rising hawkishness at the Federal Reserve is about to make it tougher for speculators.
While too soon to panic with rate hikes probably years away, strategists worried Wednesday’s meeting and forecasts would raise pressure at some of the market’s more exuberant fringes.
U.S. stocks fell as much as 1% before recovering, two-year Treasury yields spiked to the highest since June and gold tumbled after central bank officials signaled they expect to raise interest rates twice by the end of 2023, earlier than anticipated just six weeks ago. Index futures dropped during Asia trading hours, with contracts on the Nasdaq 100 sliding as much as 0.9%.
The shift in tone tested high-flying pockets of the stock market, areas where already-stretched valuations become tougher to justify if borrowing costs rise amid persistent higher inflation. Cathie Wood’s main tech exchange-traded fund fell 1.3% and meme darling AMC Holdings Inc. lost 9%.
“Large cap tech will be fine, but this shift from the Fed is negative for speculative tech. Bottom line,” Dennis DeBusschere, head of portfolio strategy at Evercore ISI, said. “Which is interesting given the recent rally in those names,” he said. “This also lowers the odds of a runaway move higher in the market.”
Here’s what other market participants are saying:
Brent Schutte, chief investment strategist at Northwestern Mutual Wealth Management Co.:
“Look, we’re still talking about 2023 — let’s put that into context. So policy is going to remain accommodative for some time well into the future and probably more accommodative than it has been if conditions were the same as in the past,” he said. “So to me, tapering is far different than tightening the economy into a recession and we are so many Fed meetings away from that. Think about 2023 just having liftoff. That’s why perhaps this doesn’t have as big of an impact — I’m sure traders are trying to trade it but we’re still talking a couple of years out to even hike a rate. The Fed this time is going to be so ultra careful to not tighten the economy into submission. They’re going to let it run hot. I think eventually that sanity will filter through to the markets.”
Michael Contopoulos, Richard Bernstein Advisors LLC’s director of fixed income and portfolio manager:
“The genie is poking its head out of the bottle — would expect the leadership change we’ve seen for the better part of a year to show itself again. Value over growth and low duration/credit risk over Treasuries/duration.”
Thomas Graff, head of fixed income at Brown Advisory:
“For stocks, perhaps some investors really thought the Fed would allow inflation to run above 2% indefinitely, or that the weak employment reports recently would somehow change their minds about the intermediate-term trajectory,” he said. “However what we are seeing today is the Fed sticking closely to their own average inflation targeting framework.”
Max Gokhman, head of asset allocation at Pacific Life Fund Advisors:
“What we got in terms of the hawkish surprise was the two hikes in 2023. Notably, this is what Fed futures were expecting, but perhaps not stock investors. Even more interesting is two of the dots went all the way up to 1.625. That’s just bonkers,” he said. “Market reaction is generally what we’d expect: stocks down and yields up in perfect asymmetry, but digging one layer deeper, it’s surprising that value is down more than growth — generally it’s the growth stocks that get hurt more by higher rates.”
Patrick Leary, chief market strategist at InCapital:
“It’s decidedly a hawkish tilt here. Certainly a quicker path to normalization and hiking rates potentially. As such we see the belly of the curve really under-performing, the 5-year sector is the worst under-performer right now. That’s definitely hawkish in that belly of the curve area. I’m looking at that as bit of a buying opportunity, it might be a bit of an overreaction. Equities are going to be concerned about the fact that at some point the Fed is going to take away the punch bowl. That’s why they’ve been slowly grinding to their all-time highs.”
Adam Phillips, managing director of portfolio strategy at EP Wealth Advisors:
“This week’s FOMC meeting was expected to be the highlight of the week and it did not disappoint. To go from expectations of Fed liftoff in 2024 to the dot plot projecting two hikes by the end of 2023 likely caught many off guard. Investors are still wondering how the Fed defines terms like ‘transitory’ and ‘substantial further progress.’”
James McCann, deputy chief economist for Aberdeen Standard Investments:
“This is not what the market expected,” he said. “This change in stance jars a little with the Fed’s recent claims that the recent spike in inflation is temporary. If price volatility is temporary then there’s no obvious reason why they need to raise rates sooner than planned, especially with the labor market having disappointed of late. For some it is certainly going to signal deeper concerns about inflation on the committee.”
Paul Ashworth, chief U.S. economist at Capital Economics, wrote:
“The Fed continued to stick to its view that the surge in inflation ‘largely’ reflects ‘transitory factors”’, but officials revised their inflation projections up significantly for this year and the median projection now shows two 25bp rate hikes in 2023,” he said. “We had assumed the Fed would be a little more willing to let inflation rip in favor of ensuring a ‘broad and inclusive’ labor market recovery – and were only forecasting one 25bp rate hike. But we clearly misjudged the Fed’s evolving reaction function and tolerance for inflation.”
Michael Shaoul, chief executive officer at Marketfield Asset Management LLC:
“For the time-being we appear to still be in a ‘phony war’, with enough ‘special cases’ in the inflation data to allow for the ‘transitory’ argument to hold sway over the market. This is largely because it is simply too inconvenient (and costly) to admit that we are already experiencing much higher and broader inflation than any mainstream estimate expected, and our concern is that the longer it takes for power of the inflationary impulse to be admitted the faster the adjustment in asset prices is likely to be.”
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ESM Board of Directors approves €100 million disbursement to Cyprus
Luxembourg – The Board of Directors of the European Stability Mechanism (ESM) approved today the disbursement of €100 million to Cyprus. This follows the positive assessment of the sixth quarterly review of Cyprus’s macroeconomic adjustment programme and approval of the supplemental Memorandum of Understanding with Cyprus by the ESM Board of Governors.
ESM Managing Director Klaus Regling said: “I am pleased that Cyprus’s adjustment programme is back on track. The legal framework for a new foreclosure procedure has entered into force, and there has also been a substantial reform of corporate and personal insolvency laws. These new regulations enable the country to effectively deal with the problem of non-performing loans. I trust that the government will continue its reform efforts so that Cyprus can sustain economic recovery.”
Mr Regling added: “Progress in Cyprus confirms that with strong ownership by a government our approach to grant a loan in exchange for economic policy conditions works. This has also been demonstrated by the successful programme conclusions in Ireland, Portugal and Spain.”
The current disbursement will bring the total amount of ESM financial assistance provided for Cyprus to €5.8 billion out of the approximately €9 billion available under the approved programme.
The ESM Board of Directors is composed of the senior officials of the euro area Member States and it is chaired by the ESM Managing Director.
There is an online information package on the financial assistance programme for Cyprus at: https://www.esm.europa.eu/assistance/cyprus


Are your indoor mold levels higher than those outside?
Mold removal cost: About $40,000
York County officials don't know how moisture got into a York County Courthouse file room, but getting rid of the resulting mold will cost the county nearly $40,000.Mold was discovered on some York County Common Pleas Court files in mid-August, Assistant County Manager David Larson said. The company called to investigate the problem, WPC Engineering, Environmental and Construction Services, found the plaster walls in the auxiliary civil court file room were damp.
The County Council on Monday authorized the money needed to remove mold from the 93-year-old building and store files in a portable trailer while the area is cleaned. Removing the files, sanitizing and cutting off the water source are expected to take about two to three weeks, and Larson said work could start as early as Monday.
No employees have reported health problems associated with the mold, but the county isn't taking any chances. "We can't have people in that area," County Manager Jim Baker said. "The contaminated section is preventing employees and others from accessing files." -- (ROCK HILL) HERALD


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Religious sites are often considered a safe haven from danger, but when storms come knocking, even Mother Nature can prove there is no escaping her wrath.
A photograph recently taken by Crystal Clevenger in central Ohio serves as a subtle reminder.
The photo shows a lightning strike not too far away from a cross at Let Love Farm, a non-profit whose mission states is devoted to connecting people to God’s peace through the caring of animals.
The cross appeared unscathed from the approximately 36,000-degree bolt, and it continues to stand over the fields of the Buckeye State.
Religious symbols don’t always get a pass from the weather, as worshipers at a church outside of Cincinnati found out several years earlier.
On June 14, 2010, a famed six-story-tall Jesus statue burned down to the metal fame after being struck by lightning.
The storm’s impacts gained worldwide attention as onlookers stopped along Interstate 75 to see the plastic foam structure ablaze.
The gigantic statue was replaced with what the Solid Rock Church says is a more fire-resistant sculpture that they hope will withstand any future act of divine intervention.
The statue’s viral sensation has come and gone, but that is not the case for a famous figure in Brazil that has seen similar weather-related issues.
The "Christ the Redeemer" statue in Rio de Janeiro is a popular symbol in Christianity and welcomes nearly 2 million visitors a year.
In addition to being an attraction for humans, the 125-foot Jesus statue has proven to be a conductor of electricity.
Brazil’s National Institute for Space Research estimates lightning strikes the giant monument six times a year.
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Because of its concrete composition and lightning rods, damage has not been as significant as with other statues, but occasionally it has had to undergo repairs for wear and tear.
The Associated Press reported the stature underwent a refurbishment in 2014 to fix the statue’s fingers and head after lightning damaged the then 83-year-old wonder of the world.
The damage scenes from around the world shouldn’t be a surprise, an estimated 8.6 million lightning bolts strike the ground each day.
With the amount of electricity in the atmosphere, it means no one is immune from the forces of Mother Nature.


text:
From original photographs by D Taylor, 1899-1900
Inscription on verso of front end paper. Second inscription on verso of title page, reads: “H D Hammond, original Boy Scout to Lord Baden Powell during the Siege of Mafeking. 1899 – 1900.” From the Preface: “Published with a view of letting all who were interested in the fate of Mafeking and its long-suffering garrison have an opportunity of seering for themselves a series of pictures taken during the siege, sometimes under circumstances of great difficulty and danger…” Black and white photographs. First photograph is of a panoramic view of Mafeking from the west across two pages. Some of the pages have closed tears to the bottom edges. Two of the photographs have small ink lettering on them. Various groups of soldiers, nurses, ex-Naval men, a group of Australians who also formed part of the Loyal Garrison; a group of German subjects who took up arms for the Queen; the Public Soup Kitchen Staff, and many others. There are photographs of damaged buildings caused by the Boers shelling; The Southern Relief Column; and the graveyard. This is a heavy item and will incur additional postage charges. Condition: Fair. Although the boards are in poor condition, the contents are good. Binding: Hardcover. Leather spine has been replaced with a new menders cloth spine. Boards in poor condition. Faded gilt lettering on front cover. Rear board shows signs of gouge marks. Delicate decorative embossed pattern can still be seen on the covers.
Date Published: Circa 1900
Publication Place: Mafeking, Cape Colony
Condition: Poor to Fair.
Binding: Hardcover. Leather spine has been replaced with a new menders cloth spine. Boards in very poor condition. Faded gilt lettering on front cover. Rear board shows signs of gouge marks. Delicate decorative embossed pattern can still be seen on the covers.
Dimensions: Large oblong. 42cm x 29cm x 2cm

domain: library


text:
JFK Website (0)
Digital Archives (61)
Common Search Term: gee
John F. Kennedy Oral History Collection(46)
Robert F. Kennedy Oral History Collection(13)
Papers of John F. Kennedy. Presidential Papers. President's Office Files.(2)
Political campaign, 1960(15)
Political campaign, 1968(7)
Kennedy, Robert F. (Robert Francis), 1925-1968(9)
Kennedy, John F. (John Fitzgerald), 1917-1963(7)
Johnson, Lyndon B. (Lyndon Baines), 1908-1973(6)
Kennedy, Joseph P. (Joseph Patrick), 1888-1969(2)
Papert, Frederic S. (Frederic Stuart), 1926-(2)
New York (N.Y.)(3)
Democratic National Committee (U.S.)(3)
United States. Congress. Senate(5)
United States. Department of Health, Education and Welfare. Public Health Service. Surgeon General. Advisory Committee on Smoking and Health(3)
United States. Department of the Interior(3)
United States. Navy(3)
Dillon, C. Douglas (Clarence Douglas), 1909-2003(2)
Galbraith, Kitty (Catherine), 1913-2008(1)
Kennedy, John F. (John Fitzgerald), 1917-1963(2)
Lincoln, Evelyn (Evelyn Norton), 1909-1995(1)
Members of the Council of Ecnomic Advisers discuss the Council of Economic Advisers under President Kennedy, the recession issue, the budget, and the relationship between the Treasury and Federal Reserve, among other issues.
Battle discusses the effect of racism and John F. Kennedy's (JFK) Catholicism on the 1960 primary and presidential elections in West Virginia and Virginia; JFK’s presidential campaigns in those states; Howard W. Smith’s control of the House Rules Committee; and Robert F. Kennedy’s 1968 presidential campaign.
Behn discusses the Secret Service before, during, and after the Kennedy administration, among other issues.
Berube discusses the 1952 campaign, Massachusetts politics, humorous and poignant anecdotes about Berube’s friendship with John F. Kennedy (JFK), and the story behind JFK’s wedding cake, among other issues.
Birkhead discusses his work on Lyndon Baines Johnson’s speech-writing team during his vice-presidential campaign in 1960, his duties as Secretary of Agriculture for Congressional Liaison, and 1961 feed grains legislation, among other issues.
Birkhead discusses specific agriculture legislation during the Kennedy administration, including among others the 1962 farm bill and 1963 wheat referendum, and Southern members of Congress, among other issues.
Boylan discusses transcribing dictated correspondence and speeches for John F. Kennedy (JFK), interactions with JFK’s constituents, and JFK’s final campaign trip though New England in 1960, among other issues.
Boylan discusses the requests for assistance from individuals and groups that would come to John F. Kennedy’s (JFK) Senate office in Boston, hiring African Americans for JFK’s Senate staff, and the members of JFK’s Boston staff, among other issues.
The Bradens discuss their roles in John F. Kennedy’s 1960 presidential campaign and Robert F. Kennedy’s 1968 presidential campaign; California politics; humorous anecdotes about the Kennedy family; and Robert F. Kennedy’s speech in Indianapolis on the night Martin Luther King, Jr. was assassinated, among other issues.
Broderick discusses John F. Kennedy’s (JFK) 1946 congressional campaign, including campaign workers, events, and strategies; his 1952 senate campaign; and humorous anecdotes illustrating JFK’s personality, among other issues.
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JOHN F. KENNEDY PRESIDENTIAL LIBRARY AND MUSEUMColumbia Point, Boston MA 02125 (617) 514-1600


The glass bottle juice drink filling machine is a rotary structure, fully automatic within and out bottle paddle wheel and semi-automatic manual up and down the bottle. This machine adopts the principle of gravity, filling valve quantitative filling when working the liquid will fill the filling valve, the bottle holder against the bottle to be filled rises, then close the upper filling valve, open the lower filling valve, liquid from the lower filling valve into the bottle to achieve the purpose of filling. The molds all have uniform temperature guides when blowing bottles, and the bottles coming out are beautiful and neat with good edge fit. The blowing machine adopts automatic control, and the instruction precisely executes the operation of each part. Control systems are imported motors, equipment quality, and stability.
Today we will learn about the daily maintenance of glass bottle juice beverage filling machine:.
1， The motor needs to be replaced regularly with lubricant.
2， Daily shutdown after the timely cleaning of residual materials, good cleaning and sanitation work to keep the surface of the machine clean, by paying attention to keeping the electrical control cabinet inside clean. Cleaning motor and line parts need to be kept dry and wipe clean with a rag.
3， The sensor is a high-precision, high-sealing, high-sensitivity device, impact, and overload are strictly prohibited, the work process shall not touch, and non-overhaul needs are not allowed to disassemble.
4, the operation is strictly prohibited to move, collision, need to be careful not to collide with the original machine when moving.
5， Long-term stop use to empty the pipeline material. Long-term stop use is better to clean and dry the inside of the machine outside the box after preservation.
6， Every day before starting the machine check the pneumatic combination of two parts of the moisture considerer and oil mist, such as excessive water should be promptly removed, the oil surface is not enough to fill the lubricant in a timely manner, generally, every six months need to refill the lubricant, the specific operation depends on the situation.
7， Check whether the equipment grounding wire contact is solid, check whether the pneumatic pipeline is leaking, whether the air pressure is stable, and whether the motor chain is appropriate.
8， To frequently observe the mechanical parts, to see whether its operation is normal, lifting, turning whether there are abnormalities, and often check the machine screws, generally every week for the screws to twist tightening reinforcement.


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Open A Kotak 811 Zero Balance Savings Account
and Avail a Lifetime Free Credit Card
and Avail a Lifetime Free Credit Card
When you start using something new, you could fall into ...
There are various kinds of credit card users. Some use...
Credit cards are a good way to make instant purchases ...
Are you finding it challenging to manage all your transactions through one savings account? Or are you a student looking to open your first bank account? Now, you don’t need to step out anywhere to open a savings account — get a Kotak 811 zero balance savings account online from your home. Plus, enjoy a lifetime free credit card!
Who should open a Kotak 811 zero balance savings account?
A Kotak811 account is ideal for:
A Kotak811 a/c is available only for individuals who don’t hold any active account with Kotak Mahindra Bank
Why should I open an 811 Digital Savings Account?
Kotak 811 digital savings account can be opened instantly.
It is a zero-balance savings account without any average minimum balance. It is best for students, homemakers, self-employed people etc., who may find it difficult to maintain a minimum amount in their accounts.
The account opening process is entirely online. So, you don’t have the hassle of filling up any physical forms or submitting photocopies of your KYC documents.
All you need to do is add your PAN and Aadhaar details during the account opening process.
You get a free virtual debit card instantly on account opening, that you can use to pay for your online purchases or pay bills online.
After opening the account, you can download the Kotak – 811 & Mobile Banking App and carry out banking transactions.
You may also select the video KYC account opening process where a bank representative completes the KYC process through a video conference. The bank will open your account within a few hours.
What are a few things that I need to keep in mind before Kotak 811 zero balance account?
You will need your PAN, Aadhaar number and Aadhaar-registered mobile number handy to open the zero balance savings account.
Accounts that are not opened through the video KYC process are e-KYC accounts. You have to complete the full KYC of your account within 12 months from the account opening date. The bank will have to close the account if the full KYC isn’t completed within a year.
Before the full KYC process, you can keep a maximum balance of Rs. 1 lakh in your account, and total credits cannot exceed Rs. 2 lakh in a financial year.
Since it is a digital account, there is no physical welcome kit.
The bank does not provide a physical debit card by default. If you’d still like one, you will have to apply for a physical debit card through the mobile banking app.
How can I get a credit card?
After you complete the full KYC and add funds to your Kotak 811 savings account, you can apply for the Kotak 811 #DreamDifferent Credit Card from your mobile banking app easily. Login to app >> Go to Apply now section >> Click on Credit card icon to start the online application.
Kotak 811 Credit Card is a secured credit card backed by a Fixed Deposit (FD). The card doesn’t have any joining or annual fee, which makes it very affordable. You also don’t need to provide any income proof. All you need to do is book a minimum FD of Rs. 10,000. You can book an FD during the credit card application process or select from the existing list of Fixed Deposits.
The credit limit of the card is up to 80% of your FD, i.e. the minimum credit limit is Rs. 8,000.
If you are a student, or don’t have a credit history, it can be one of the best credit cards to build credit history.
Go ahead and open a Kotak 811 zero balance savings account now and enjoy the benefits of a lifetime free credit card.
Giving Aadhaar details is voluntary.
Issuance of credit cards is at the sole discretion of Kotak Mahindra Bank Limited. All features and benefits are subject to Credit Card Terms and Conditions. Please read the Credit Card terms and conditions carefully provided on the bank website www.kotak.com
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domain: economics


text:
Duarte Lebre de Freitas > CMS > Lisbon, Portugal > Lawyer Profile
Rua Castilho, 50
- Go to...
Duarte Lebre de Freitas
Duarte Lebre de Freitas is a senior associate in Public Law practice at CMS Portugal. He is experienced in public law, with a special focus on public procurement, urban planning, the establishment and operation of public professional associations and public employment, as well as administrative procedures in general, advising both different public administration entities and private individuals in their dealings with public entities.
He also carries out his activity in Administrative Litigation, representing public entities and private individuals, particularly in the field of public procurement, expropriations and town planning.
CMS is well versed across a broad array of public law matters, spanning infrastructure projects, regulatory issues, public procurement and administrative proceedings. Specialised in administrative law, Gonçalo Guerra Tavares handles a wide range of transactions, public tender procedures, concession contracts and arbitration proceedings relating to public works. Duarte Lebre De Freitas ‘has solid knowledge in matters of public law and administrative litigation’ and António Magalhães Menezes assists companies and public entities on regulatory matters.

domain: law


text:
Monday, November 16, 2009
virtual cupcake, baby shower edition
These are some cupcakes I made for a baby shower/mama blessing. I made marshmallow fondant, which was super easy and also super easy to work with, along with vanilla cupcakes and vanilla buttercream frosting (requested by the mama). They turned out delicious, if I do say so myself. I'm really not a fan of regular old rolled fondant, but since I love marshmallows, I thought I'd give this a try and I'll definitely use it from now on for decorating. An added bonus is that the girls had a blast playing with it too!
To make the fondant, I poured a 15 ounce bag of mini marshmallows into a big glass bowl, added about 2 teaspoons of water, and microwaved them at 30 second intervals until everything was all melted. Then I sifted about 2 cups of powdered sugar and stirred that in. I waited a bit for the mixture to cool, then I poured it onto the counter (that I greased VERY heavily with shortening and extra powdered sugar). I kneaded everything until it was smooth, and then I separated it into thirds (one for the kids, one to stay white, one to dye pink - I used gel food coloring and it worked really well). Then I just rolled it out to about 1/8 of an inch and cut and decorated away. I'd say that one recipe of fondant will decorate about 24 cupcakes, depending on how you decorate them. For these, I spread a little buttercream on them, and then topped them with a round of fondant that I cut our with a cookie cutter. Then I made fondant bows, roses, and other shapes (and baby's initials).
For the buttercream, I used this recipe:
2 1/2 sticks unsalted butter, softened
2 cups powdered sugar, sifted.
pinch of salt
2 t vanilla
2 T heavy cream
In a stand mixer, cream butter until light and fluffy using the whisk attachment. Add sugar and salt, cream for about 4 minutes or until very smooth. Add cream and vanilla, whip another 3 minutes. Use immediately, store extras in the refrigerator and bring to room temperature to use again. This is definitely the best tasting buttercream I have made in a while!

domain: food


Select Pincode to continue
product-related queries, please contact_us on: [079-30130111 / 09510070111.
- Capacity: 70 Litres; Ideal for room size of upto 450 Sq Ft.
- Always allow for CROSS-VENTILATION in your area / room, else cooler won’t work effectively
- Strong wheels for easy mobility ; Air Throw Distance (mt): 11/36 ; 3 Speed Settings ; Motor Speed: 1400 rpm
- Large cooling pad area for better cooling
- Power: 205 Watts; Operating voltage: 230 V; Works on Inverter: Yes, Warranty: 1 year, Frequency: 50HZ
- Package Includes: Air cooler
- This cooler has blower for powerful air delivery and hence it is expected to have higher noise level as compared to fan based coolers, Its compact design makes it apt for all the rooms
Powerful fan, Automatic vertical swing
|Power Consumption||205 W|
|Included Components||One Unit Air Cooler, user manual, warranty card|
|Item Dimensions LxWxH||63.5 cm x 50.0 cm x 112.5 cm|


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Availability: Haus Iris Hotel Garni
Double RoomMax Occupancy: 2 guests (up to 1 child, 1 infant)
Single RoomMax Occupancy: 1 guest
Hotel with a fitness center, in Herzberg am Harz (Sieber)
This hotel is located in Herzberg am Harz (Sieber), where regional attractions include Osterode Old Castle, Harz National Park, and Old Town Hall. Regional attractions also include Wurmberg Gondola and Wurmberg.
Recreational amenities at Haus Iris Hotel Garni include a sauna and a fitness center. Other amenities include ski storage and complimentary wireless Internet access.
Televisions come with satellite channels. Guestrooms also feature complimentary wireless Internet access, climate control, and hair dryers.Information missing or incorrect? Tell us!
Haus Iris Hotel Garni Amenities
Haus Iris Hotel Garni features a sauna and a fitness center. High-speed wireless Internet access is complimentary. This Herzberg am Harz hotel also offers a rooftop terrace, a terrace, and tour/ticket assistance.
- Total number of rooms - 18
- Number of floors - 2
- Fitness facilities
- Tours/ticket assistance
- Free Wi-Fi
- Rooftop terrace
- Luggage storage
- Ski storage
- Laundry facilities
- Safe-deposit box at front desk
- Conference space size (meters) - 20
- Number of meeting rooms -
- Number of buildings/towers - 2
Available in all rooms: Free Wi-Fi
Available in some public areas: Free Wi-Fi
- Room Amenities
- Daily housekeeping
- Private bathroom
- Hair dryer
- Shower only
- Iron/ironing board (on request)
- Rollaway/extra beds available
- Satellite TV service
- Free Wi-Fi
- Climate control
- Cribs/infant beds (complimentary)
Recreational amenities at the hotel include a sauna and a fitness center.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Snowboarding nearby
- Downhill skiing nearby
- Cross-country skiing nearby
- Mountain biking nearby
- Hiking/biking trails nearby
- Bicycle rentals nearby
Haus Iris Hotel Garni Policies & Fees
Check-in time starts at 3 PM
Check-in time ends at 8 PM
Special check-in instructions:
Special Instructions: Please contact the property ahead of time if you are planning to arrive after 8 PM.
Check-out time is 10 AM
- Payment types
Accepted at this hotel: MasterCard, Visa
Pets allowed, Only dogs are allowed
Extra-person charges may apply and vary depending on hotel policy.
- The following fees and deposits are charged by the property at time of service, check-in, or check-out.
- Self parking fee: EUR 3 per night (in/out privileges)
- Pet fee: EUR 3.00 per pet, per night
- Rollaway bed fee: EUR 22.00 per night
- Facilities fee: EUR 8.00 per person, per day and includes use of:
Hotelstars Union assigns an official star rating for properties in Germany. This property is rated 3 stars.

domain: travel


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By Deseret Book Press Release
Elder Holland's New Book A Timely Message on the Importance of Personal Purity
SALT LAKE CITY, UTAH -- Perhaps no message is of more importance today than
that of the importance of staying morally clean and pure. It's a message
powerfully delivered by Elder Jeffrey R. Holland in "Of Souls, Symbols, and
Sacraments (Deseret Book, $10.95 hardcover book, $10.95 audiocassette,
$12.95 CD talk on tape, $15.95 videocassette).
Elder Holland discusses these private and sacred issues in an honest but
delicate and compassionate manner, always couching his comments in the
language of the scriptures and emphasizing the love of God and the power of
the Atonement. Turning his remarkable spiritual and literary talents to the
subject of human intimacy, Elder Holland reviews the doctrinal seriousness
of personal purity and examines "why we should be clean, and why moral
discipline is such a significant matter in God's eyes." Relying on scripture
and statements from the prophets and using thought-provoking insights from
poets and philosophers, he explains clearly and forcefully why Latter-day
Saints cannot adopt the world's views about intimacy.
"Of Souls, Symbols, and Sacraments" is an invaluable companion for parents
teaching their families the law of chastity and for young adults struggling
with why to say no when the world is pressuring them to say yes.
About the Author:
Elder Jeffrey R. Holland received his bachelor's and master's degrees from
Brigham Young University, and a master's degree and Ph.D. in American
Studies fromYale University. He was appointed president of BYU in 1980,
holding that position until called as a member of the First Quorum of the
Seventy in 1989. In June 1994, he was called as a member of the Quorum of
the Twelve Apostles of The Church of Jesus Christ of Latter-day Saints. He
and his wife, Patricia Terry Holland, are the parents of three children.

domain: literature


text:
About alcott Explorer Adventure Backpack Dog Pack - Medium
Closeouts. Isn't it about time your dog carried his own supplies? Lighten your load with the alcott Explorer Adventure Backpack dog pack. The four spacious pockets feature an integrated waste-bag dispenser and a thermal lining to hold a freeze pouch or cold food. It's lightly padded and fully adjustable to keep things comfortable for your canine.
Specs about alcott Explorer Adventure Backpack Dog Pack - Medium
- Material: Polyester
- Weight: 9 oz.
- Sizing: 10" length, 17" - 21" chest, 22" - 30" waist
- Made in China
- Visit our Dog Gear Guide
Do you own this product? Write a review and help others with their buying decisions!
Most Helpful 4-Star Review
lightweight and fits well.Verified Buyer Reviewed by MonsterMax the wonder dog from Idaho on Tuesday, August 1, 2017The bag is smaller than I expected
happy dog happy meVerified Buyer Reviewed by xxx from Washington on Wednesday, April 26, 2017I use this with my medical alert dog for longer walks and hikes; she carries my supplies with a smile. I did have to make some adjustments to get it to fit her better, but we are good to go now.
Question & Answer
Questions about this product? Get answers from community and staff experts.

domain: pet


SYDNEY, Dec 3 (Reuters) - The Australian and New Zealand dollars were headed for their fifth week of losses on Friday as the spread of the Omicron variant clouded the outlook for global growth just as markets were pricing in a faster pace of U.S. rate hikes.
The Aussie was pinned at $0.7081 , having shed 0.5% for the week so far, but did manage to hold above the 13-month low of $0.7063 hit earlier in the week.
The next bear target is a trough from November 2020 at $0.6990, while major resistance is up at $0.7172.
The kiwi dollar was also down about 0.5% for the week at $0.6796 , but again above the low of $0.6773. It has little in the way of support until $0.6700.
With the U.S. Federal Reserve signalling a faster pace of tapering, the market is wondering how the Reserve Bank of Australia (RBA) might react at its policy meeting next week.
Most analysts assume it is too early for the RBA to change tack on its dovish outlook of no rate hikes in 2022, though there was some talk it might flag a cut in its bond buying.
RBA Governor Philip Lowe has repeatedly stated the QE programme would be reconsidered at the February meeting, with most analysts assuming it would halve to A$2 billion ($1.42 billion) a week and end it in May or June.
"If the Fed does accelerate the pace of its bond tapering, then we think the RBA could well decide to end its QE program altogether in February," said David Plank, head of Australian economics at ANZ.
However, he doubted the RBA would flag any change next week, in part because the Fed does not meet until Dec. 15.
Plank expects the first rate hike to come in May 2023 and rates to end that year at 1%. The market is far ahead, with a rise to 0.25% almost fully priced by June next year and rates approaching 1% by the end of 2022.
The bond market has moved some way to price in a greater risk of early hikes with three-year yields having climbed to 0.94% from 0.25% at the end of September.
Longer-term bonds have had a more bullish run in line with a rally in Treasuries, taking 10-year yields down almost 15 basis points this week to 1.644%.
($1 = 1.4118 Australian dollars)
Editing by Sam Holmes


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Global conservation organization WWF has welcomed the release of an acoustic version of Kirsty Bertarelli’s song “Green”, the proceeds of which are destined to support WWF conservation projects around the world.
Kirsty Bertarelli was inspired to produce an acoustic version of Green after she performed live at WWF’s 50th anniversary Panda Ball last year.
“It was such an honor to be a guest at WWF’s Panda Ball,” she said. “I performed a special acoustic version of Green and decided to dedicate this new version to WWF’s cause.”
The lyrics of “Green” talk about the destruction of the environment and were influenced by Kirsty’s experience of the issue, as well as of how much the next generation care about being the custodians of our planet.
“Kirsty Bertarelli’s gesture of donating the proceeds of her song Green to WWF’s vital conservation projects around the world is a generous symbol of her commitment to the environment,” said Jim Leape, Director General of WWF International.
Net proceeds from iTunes downloads of the acoustic version of Green will be donated to WWF.


Production Flexibility Program payments in Louisiana totaled $885 million from 1995-2021.
Congressional Districts in Louisiana Receiving Production Flexibility Program payments, 1995-2021
|Rank||District||Production Flexibility Program|
|1||5th District of Louisiana (Rep. Ralph Abraham)||$379,995,059||42.9%||42.9%|
|2||3rd District of Louisiana (Rep. Clay Higgins)||$88,849,089||10.0%||53.0%|
|3||4th District of Louisiana (Rep. Mike Johnson)||$27,105,983||3.1%||56.0%|
|4||6th District of Louisiana (Rep. Garrett Graves)||$16,954,010||1.9%||57.9%|
|5||2nd District of Louisiana (Rep. Cedric Richmond)||$468,297||0.1%||58.0%|
NOTE: Not all recipients were able to be placed into Congressional Districts so the District total may not total 100%. Nationally 96% of all program monies were designated into a Congressional District
Source: Environmental Working Group. Compiled from USDA data.


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Where sustainable luxury is concerned, Lake House's Dairy Flat gets everything right. A 38-acre regenerative farm set amid rolling hills in the hamlet of Musk, the lodge offers a unique retreat to immerse yourself in eco-luxury. Interiors have been curated by Larissa Wolf-Tasker; a mix of modern and vintage pieces that unite together in perfect harmony. Making the most idyllic space for friends and family to gather, the sense of place is undeniable—a retreat experience that will be remembered for a lifetime.
Designed and maintained by the creative thinkers behind the equally as exuberant flagship hotel, Lake House, The Dairy Flat offers six suites in a unique country lodge style for guests keen to embrace the wonder of life on a productive farm.
Lying on 38 lush acres of red volcanic soil, marvel at your surroundings of vegetable gardens, a 300-tree orchard, 250-tree olive grove and 5-acre vineyard. For your own personal use, stroll through the sprawling gardens and watch the early morning harvest from your window, smell the delicious scents of loaves of bread being baked at the bakehouse and take a guided tour of the charming vineyards.
Formal garden rooms are eccentrically detailed, with interiors designed by commissioned artists and artisans and led by Larissa Wolf-Tasker, creating a house that blossoms with personality. The overall feeling is one of being right at home, so sit back, relax and breathe in utter contentment.
With most produce and baked goods directed to the Lake House Restaurant for use, dishes present the chef's and gardener's delicious experiments with rare and interesting vegetables, fruits and herbs. All baking comes from the Dairy Flat, with regular sourdough baking classes for Lodge guests.
Wake every morning to views of the harvest, as the gardeners get ready for the day's haul to the Lake House kitchens, and absorb the purity of your natural surroundings.
Daylesford - Australia
(Usually reply within 24 hours)
© 2020 HIP Media Group Limited All Rights Reserved.


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Glee star Amber Riley talks Lea Michele’s alleged racism on Ziwe
The controversy recently resurfaced after Michele landed one of Broadway’s most coveted roles as Fanny Brice in Funny Girl. Her casting coincided with fellow Glee alum Jane Lynch departing the show, stoking speculation that there was lingering bad blood between the former co-stars.
“Would you say that your famous coworker doesn’t see race and is in fact rude to all of her coworkers?” Ziwe continues.
“I think that she would probably say she doesn’t see race, but as we discussed earlier, everyone does,” Riley says.
Elsewhere in the clip, the recent Dancing With The Stars winner does not seem to look back on her Glee experience with particular fondness.
“We have diversity training on our show,” Ziwe tells her.
“I wish our show had that,” Riley laughs. “We did not.”
Ziwe is now airing on Showtime.


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What do you think is needed in Zimbabwe to both improve food security and farmers incomes?
In order to restore farmers' livelihoods they need to be supported in a process of sustainable private sector-driven agricultural recovery to achieve tangible household-level impact in food security and generate more household income, as well to promote more rural employment.
The U.S. government through USAID is doing this by supporting programs that provide effective rural extension, trainings and demonstration farms in order to improve farm management by small holder producers. The programs also include support for inputs and market linkages between the farmers and agro-processers, exporters and buyers. These programs are broad-based and cover all communal small holder farmers throughout the country.
At present, the U.S. is the largest provider of direct food aid in Zimbabwe. We are working with our partners to move from food aid to food security assistance which will use more market oriented approaches and combine livelihoods programs as noted above, which will reduce the need for food distribution.
Do you think Zimbabwe needs more private sector investment? If so, what are ways the U.S. government and other donors can help encourage both domestic and foreign investment?
Zimbabwe certainly needs more foreign direct investment. There is little chance that the country can internally generate the investments required to promote the economic growth it needs without it. But it is the government of Zimbabwe that is responsible for creating the business enabling environment to attract investment including both foreign and national.
At present, much more needs to be done in policy and the legal and regulatory framework and in the rhetoric and actions by the government in order to create the environment conducive to attract investment. Without the clear will of the government to be FDI-friendly there is not much that the donors can do.


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Can in utero exposure to DES adversely affect the immune system ?
1988 Study Abstract
Soon after recognition of the increased risk of vaginal clear cell adenocarcinoma in women with in utero exposure to diethylstilbestrol (DES), the National Cancer Institute funded a large multicenter epidemiologic cohort study, the DESAD Project. The purpose of this national project was to describe the prevalence of DES-associated genital tract changes among women exposed in utero and to compare these findings with an unexposed control group. Additionally, the study sought to determine the incidence of cancer and other diseases in the exposed and unexposed cohorts. Because of the possibility that prenatal exposure to DES might adversely affect the adult immune system, the participants in the DESAD Project were surveyed to determine the prevalence of autoimmune diseases. The lifetime history of these disease is reported in this preliminary communication.
As noted, research in rodents suggests that perinatal exposure to DES can markedly affect the adult rodent immune system,l whereas limited observations in humans raise the possibility of similar changes in the human immune system. The information presented in this preliminary communication also supports the concept that human exposure before birth to DES may subsequently affect the adult immune system. Unfortunately, no detailed serologic studies of the immune status of women exposed to DES in utero have yet been reported in the literature. Thus, it is not possible to identify any specific immune defect or an underlying mechanism for this association.
Although these data suggest that there is an increase in autoimmune disease among women exposed before birth to DES, the authors wish to caution against drawing firm conclusions from these preliminary findings. Although the overall occurrence of autoimmune disease is statistically significant with one-sided chi-square tests, the number of observed events is small, and the confidence intervals are wide. Additionally, the history of autoimmune disease has not yet been documented for all participants. At the present time, only one of the five centers has reviewed the medical histories to validate the questionnaire information. Twenty-four autoimmune diseases were reported by 23 women followed by the Mayo DESAD Center. Six women received all of their medical care outside of Mayo, leaving 18 evaluable cases. Of these 18 reported cases of autoimmune disease, 14 were confirmed. Two of the unconfirmed diseases occurred in an individual with longstanding psychiatric difficulties. Thus, there appeared to be only two cases in which a reliable participant reported a disease that could not be confirmed by examination of medical records.
Although the data reported here are necessarily indirect, they do indicate reason for concern. Consequently, it would seem prudent for investigators exposed women to determine the prevalence (and, it is hoped, incidence) of autoimmune diseases among their exposed cohorts. Additionally, studies should be undertaken to thoroughly investigate the function of the immune system in DES-exposed women by means of appropriate serologic testing.
- Read and download the full study (free access) Increased occurrence of autoimmune disease among women exposed in utero to diethylstilbestrol, FERTILITY AND STERILITY, Vol. 49, No.6, June 1988.
- Lifetime History of Autoimmune Diseases Among DES-Exposed Women (Record Review Cases) and Controls – image credit fertstert S0015-0282(16)59965-8.
DES DIETHYLSTILBESTROL RESOURCES
- Studies on DES and ADHD, autism, Down’s Syndrome, Immune-related Disease.
- Diethylstilbestrol DES studies by topics.

domain: biology


text:
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Karl Friedrich August Rammelsberg
He was educated for the medical profession and graduated in 1837 at Berlin University. In 1841 he became privatdozent in the university, and in 1845 professor extra-ordinary of chemistry. He relinquished this post in 1851 to take the chair of chemistry and mineralogy at the Royal Industrial Institute. In 1874 he was appointed professor of inorganic chemistry, and director of the second chemical laboratory at Berlin.
Additional recommended knowledge
Distinguished for his researches on mineralogy, crystallography and analytical chemistry, he laboured also at metallurgy, and yet found time for a series of important textbooks, in which his learning and sound judgment were combined with a lucid and accurate statement of facts. He was author of:
A nickel arsenide mineral named rammelsbergite is named after him. He died at Gross Lichterfelde, near Berlin, on the 28th of December 1899.
This article incorporates text from the Encyclopædia Britannica Eleventh Edition, a publication now in the public domain.
Categories: German mineralogists | German chemists
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Karl_Friedrich_August_Rammelsberg". A list of authors is available in Wikipedia.|

domain: chemistry


text:
SABBATH QUEEN, a feature documentary filmed over 20 years, follows Rabbi Amichai Lau-Lavie’s epic journey as the dynastic heir of 39 generations of Orthodox rabbis including the Chief Rabbis of Israel. He is torn between rejecting and embracing his destiny and becomes a drag-queen rebel, a queer father, and the founder of Lab/Shul – an everybody-friendly, God-optional, artist-driven, pop-up experimental congregation (www.labshul.org.) SABBATH QUEEN joins Amichai on a lifelong quest to creatively and radically reinvent religion and ritual, champion interfaith love and challenge patriarchy and right-wing orthodoxies. The film interrogates what Jewish survival means in a difficult rapidly changing 21st century.
After 20 years of filming, DuBowski is in post-production and raising funds to complete the film. All donations are tax-deductible.
Funding provided by The Sundance Institute Documentary Film Program as well as The Sundance Institute Catalyst Program and Talent Forum, The Nathan Cummings Foundation, The Catapult Film Fund, The Hartley Film Foundation, The Lynn & Jules Kroll Fund for Jewish Documentary Films, The Dorot Foundation, The Shelley & Donald Rubin Foundation, Reboot, Jeff Schoenfeld, Carla Solomon, Barbara Dobkin Foundation, Daryl and Steven Roth Foundation, The Jeannie Blaustein and Peter Bokor Fund of The Jewish Communal Fund, Bertha Foundation, Influence Film Foundation, Genuine Article Pictures, and an intergenerational team of Executive Producers from their 20’s through their 70’s from Broadway, film, advocacy, government, and philanthropy, including Jeffrey Solomon and Audrey Weiner, Adrian Salpeter, Jen Chaiken, Ben Lowy, Jess Jacobs and Audrey Rosenberg, Lynda Weinman and Bruce Heavin, S. Asher Gelman, and Matt Nosanchuk.
How To Donate
All donations for the production and distribution of SABBATH QUEEN are tax-deductible to the fullest extent of the law.
If you would like to make a donation online, please click here:


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Dr. Debrisha Johnson
Bee Busy Wellness Center
Debrisha Johnson is a concerned and attentive nurse practitioner serving the community of Houston, TX. She attended Northwestern State University, where she earned her master's in family nursing as well as her bachelor's and associate's in nursing. Ms. Johnson is a part of Bee Busy Wellness Center. She is a member of the American Academy of Nurse Practitioners. Patients see her for a variety of reasons, including restless legs syndrome, peripheral neuropathy/carpal tunnel, measles/rubeola, asthma, and arthritis. Ms. Johnson treats a range of conditions, and she is eager to help the wider community receive the care they deserve. She is dedicated to helping patients receive the treatment they need so they can enjoy a positive and fulfilling lifestyle.
Clinical Nursing Practice, Family Nursing


The Dancearts Competition Team is open to dancers ages six to eighteen. As a team member, dancers have the opportunity to experience rehearsals and performances at a more professional level. It is important that dancers' conduct and attitude during classes and rehearsals is positive and respectful. This is also expected in relationships with fellow dancers, teachers, choreographers at the studio and any other dance setting. As a competition dancer, members represent Dancearts and set an example for the rest of our Dancearts students.
Dancers must be enrolled in, and attending, a ballet class for the entire school year at Dancearts or Halcyone Perlman School of Dance (also in Columbia).
Dancers must be enrolled in, and attending, a technique class for the entire year that relates to the dance style of each of their competition pieces. Three un-excused absences from a technique class may result in removal from the competition piece.
Summer Intensive Workshops at Dancearts are required for all competition dancers.


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Hybrid 'Celebrity' is justly famous for its large, tasty, red Tomatoes with a pleasing, rounded shape. Plants are vigorous and disease resistant and also widely adapted to various growing conditions around the country. An All-America Selections Winner. Fruits weigh 8-12oz and ripen about 70 days from transplant. Plants are resistant to Verticillium Wilt, Fusarium Wilt (Races 1 and 2), nematodes, Tobacco Mosaic Virus, Alternaria Stem Canker, and Gray Leaf Spot (Stemphylium). Determinate.
Our stocky seedlings are grown and shipped in 3in pots that are a full 4in deep, so the plants you receive have strong, well-developed root systems. For more information on growing and care, click Growing Guide.
SHIPPING GUIDELINES FOR STARTS - Hardiness Zone 7-9: shipping starts late April. Zone 6: shipping starts early May. Zones 1-5: shipping starts mid-May.
Please Note: These shipping guidelines are based on normal weather conditions within your zone. We begin shipping to the warmest zones first and then work our way to the colder zones. Due to weather, growth requirements, and product quality, we cannot ship your plants outside of these shipping guidelines.
Every state has agricultural regulations that restrict the shipment of certain plants. We are sorry, but we cannot ship this item to the following state: GA


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At Siena Golf Club in Las Vegas, Nevada, at the foothills of the Spring Mountains, golfers will be entertained by the variety and pacing of the golf course. The natural beauty of Siena along with the ideal blend of doglegs, straightaways, bunkers and water hazards make the golf course renowned in the Las Vegas Valley. The elevated terrain provides panoramic views of the mountains as well as the bright lights of the Vegas Strip. A par 72 golf course playing from 5,600 to 6,800 yards, Siena Golf Club is perfect for all ages and abilities. Tee times are available. Get yours today.
Siena Golf Club Tee Times

domain: geography


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If you are a newbie in the world of playing craps, you will need to familiarize yourself with the basic rules. This is an important part of the game and is something that should be considered before participating in any type of play. You should be able to understand the different rules and what they mean.
Craps is a skill-based game that requires many elements that are needed to make it go. These elements include the ability to read, understand, and follow instructions of the game. The knowledge of these rules will give the player the chance to enjoy playing the game much more. After all, you would not enjoy playing if you do not know what the rules are.
The basic rules are laid out in each game and how they should be followed. You will want to look at the rules and be familiar with them. There are a few basic rules in the games that you must be aware of. It will be important for you to know what each one entails.
One of the basic game that you should know about is the elimination game. In this game, there are seven balls that need to be dealt to all the players. There is one person that is designated to serve as the shooter while the others have to shoot them.
There are four conditions that are required of you when dealing with the balls. The first condition is that the balls must come from the top of the deck. The second condition is that the shooter is the one who lays the ball down on the table. The third condition is that you cannot place a ball anywhere else on the table.
The fourth condition is that the shooter must lay the ball on the table after scoring. A fifth condition that you must follow is that you cannot move the shot stop of the shooter toany location that the shooter can move to. The last condition is that you must have a valid betting card on the shooter card.
If you are a craps beginner, you will want to be aware of these rules before you start playing craps. This will give you the opportunity to understand the different types of conditions and rules that are involved in the game. It will also help you ensure that you understand the game and what you are supposed to do while playing.
If you are not familiar with the rules of the game, you will want to talk to your friends or play with them. You can also check out the rules online and learn the rules. It is a great idea to read through the rules and follow them as best as you can. If you do not, you will likely get frustrated and leave the game early.

domain: hobby


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Aug 30, 2013
Skipping multiple exons at the same time, by using a combination of antisense oligonucleotides, offers the potential to treat a significant number of Duchenne patients. This would address one of the major limitations of current antisense therapy, in that the approach is “personalized” and designed to skip a single exon.
Specifically, exons 45 to 55 cover the main mutation “hotspot” of the DMD gene and this area is thought to harbor mutations that are present in more than half of Duchenne patients.
Individuals with this specific 45-55 deletion show almost asymptomatic skeletal muscle involvement or exceptionally mild clinical symptoms and it is this observation that has spurred interest in developing strategies for multi-exon skipping.
This review (https://www.hindawi.com/journals/bmri/2013/402369/), by leading researchers in the field of multiexon skipping, highlights novel findings from a DMD mouse model utilizing systemic multiexon skipping targeting exons 45–55.
The authors highlight the hurdles and limitations impeding the clinical translation of this approach and provide a perspective on the opportunity for exon 45–55 skipping in DMD patients.
Title: Development of Multiexon Skipping Antisense Oligonucleotide Therapy for Duchenne Muscular Dystrophy.
Ref. BioMed Research International, Volume 2013 (2013), https://dx.doi.org/10.1155/2013/402369
Authors: Yoshitsugu Aoki, Toshifumi Yokota, and Matthew J. A. Wood


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HIV – A Sexually Transmitted Disease
Many diseases harm the human body. Among these diseases, the most common ones are auto-immune and sexually transmitted diseases. Sexually transmitted diseases are not spread through any virus or bacteria present in the atmosphere. These are transmitted from one person to the other through physical and intimate contact.
However, these diseases if not diagnosed or treated on time can be fatal for the patient. Many diseases fall into the category of sexually transmitted diseases.
STDs used to be called venereal conditions or VD. They’re among the most common contagious conditions. It’s estimated that 25 of all Americans have an incorrigible STD. Each time, 20 million new cases are reported; half of these infections are among people periods 15 to 24 and they can have long-term consequences. HIV test in UAE and USA can be easily conducted.
STDs are serious ails that bear treatment. Some STDs, similar to HIV, can not be cured and can be deadly. By learning further about STDs, you can learn ways to cover yourself. STD testing is not difficult anymore. Normally, full sexual health screening is required to discover the actual cause of HIV.
You can get an STD from vaginal, anal, or oral coitus. You can also be infected with trichomoniasis through contact with damp or wettish objects similar as apkins, wet apparel, or restroom seats, although it’s further generally spread by sexual contact.
With the preface of largely active antiretroviral remedies, AIDS judgments and deaths declined mainly in the United States from 1995 to 1998 and remained stable from 1999 to 2008 at a normal of AIDS judgments and deaths per time, independently. Despite the decline in AIDS cases and deaths, at the end of 2008, estimated persons were living with HIV, including (20.1) whose infection remains undiagnosed. In particular, the undiagnosed HIV infections leave the sexual mates of these persons at high threat of infection.
Mortal Immunodeficiency Contagion (HIV) and Acquired Immune Deficiency Syndrome (AIDS)
AIDS is caused by the mortal immunodeficiency contagion (HIV), which is spread through vulnerable sexual intercourse with an infected person or through using a polluted needle to fit medicines. It can also be spread through intravenous medicine use and much lower generally, blood, blood products, needles, or other sharp instruments defiled with infected body fluids or blood.
Upon entering the rotation, the HIV microorganisms abduct a type of white blood cell known as T- coadjutor lymphocytes ( also known as CD4 cells, T cells, or coadjutor-Ts). In a person with a healthy vulnerable system, T- cells band together to help defend the body against conditions. But the commandeered T- cells are forced to mass-produce clones of HIV. Left undressed, coadjutor T cells mass-produce large figures of HIV, this further depletes the number of normal coadjutor-Ts in the bloodstream, rendering the individual vulnerable to AIDS-defining illness.
The five most common of these are
- Pneumocystis carinii pneumonia
- HIV wasting pattern
- Candidiasis of the esophagus
- Kaposi’s sarcoma
to order one for you. Some health departments or community-grounded associations also give tone-test accouterments for free.
Some prominent symptoms of HIV
There are several symptoms of HIV. Not everyone will have the same symptoms. It depends on the person and what stage of the complaint they’re in. Below are the three stages of HIV and some of the symptoms people may witness.
- Stage 1 Acute HIV Infection
Within 2 to 4 weeks after infection with HIV, about two-thirds of people will have a flu-suchlike illness. This is the body’s natural response to HIV infection.
Flu-suchlike symptoms can include
- Night sweats
- Muscle Pangs
- Sore throat
- Blown lymph bumps
- Mouth ulcers
These symptoms can last anywhere from many days to several weeks. But some people don’t have any symptoms at each during this early stage of HIV.
Get tested as soon as possible! Find an HIV testing point near youLocator.HIV.gov Don’t assume you have HIV just because you have any of these symptoms — they can be analogous to those caused by other ails. But if you suppose you may have been exposed to HIV, get an HIV test.
Here’s What To Do
Find an HIV testing point near you — You can get an HIV test at your primary care provider’s office, your original health department, a health clinic, or numerous other places. Use the HIV Services Locator to find an HIV testing point near you.
Request an HIV test for recent infection — Utmost HIV tests descry antibodies (proteins your body makes as a response to HIV), not HIV itself. But it can take many weeks after you’re infected for your body to produce them. Other types of tests can descry HIV infection sooner. Tell your croaker or clinic if you suppose you were lately exposed to HIV, and ask if their tests can descry early infection.
Know your status — After you get tested, be sure to learn your test results. However, see a croaker as soon as possible so you can start treatment with an HIV drug If you’re HIV-positive. And be apprehensive when you’re in the early stage of infection, you’re at veritably high threat of transmitting HIV to others. It’s important to take away to reduce your threat of transmission. However, there are forestallment tools like exposure prophylaxis (PrEP) that can help you stay negative If you’re HIV-negative.
Stage 2 Clinical Quiescence
In this stage, the contagion still multiplies, but in veritably low situations. People in this stage may not feel sick or have any symptoms. This stage is also called habitual HIV infection.
Without HIV treatment, people can stay in this stage 10 or 15 times, but some move through this stage briskly.
Still, exactly as specified and get and keep an undetectable viral cargo, you can cover your health and have effectively no threat of transmitting HIV to your sexual mate (s), If you take HIV drug every day.
But if your viral cargo is sensible, you can transmit HIV during this stage, indeed when you have no symptoms. It’s important to see your health care provider regularly to get your viral cargo checked.
Stage 3 AIDS
Still, ultimately the contagion will weaken your body’s vulnerable system and you’ll progress to AIDS ( acquired immunodeficiency pattern) If you have HIV and you aren’t on HIV treatment. This is the late stage of HIV infection.
Symptoms of AIDS can include
- Rapid weight loss
- Recreating fever or gushing night sweats
- Extreme and unexplained frazzle
- Dragged lump of the lymph glands in the armpits, groin, or neck
- Diarrhea that lasts for further than a week
- Blisters of the mouth, anus, or genital
- Red, brown, pink, or purplish blotches on or under the skin or inside the mouth, nose, or eyelids
- Memory loss, depression, and other neurologic diseases
Each of these symptoms can also be related to other ails. The only way to know for sure if you have HIV is to get tested. However, a health care provider will diagnose if your HIV has progressed to carry 3 (AIDS) grounded on certain medical criteria If you’re HIV-positive.
Numerous of the severe symptoms and ails of HIV complaint come from the opportunistic infections that do because your body’s vulnerable system has been damaged. See your health care provider if you’re passing any of these symptoms.


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Effect on weight, body mass index BMI, and blood pressure A mean weight loss of 3. Not all of our patients responded to the KD. Several clinical studies confirm that patients tolerate well LCD for a long time and there are definitive benefits of this type of feeding as patients are well nourished without feeding tumor cells. It has been viewed as something that can impact health, as well. DG is our clinical oncology nurse and KD is our registered ketogenic dietician. As with red meat and cancer, the relationship between fruits and vegetables and cancer is difficult to determine. During that same time, Nobel laureate Otto Warburg found that cancer cells thrive on glycolysis, producing high lactate levels, even in the presence of abundant oxygen. National Center for Biotechnology Information, U. When considering mechanisms, we also have to consider potential beneficial effects of a food. Cancer Res. J Bioenerg Biomembr.
Combining a ketogenic diet with standard chemotherapeutic and radiotherapeutic options may help improve tumor response, although more research is needed. As early as bc, fasting was used as an effective treatment for many medical ailments. Fasting continued into modern times, and in , Guelpa and Marie proposed fasting as an antiepilepsy treatment. A low-carbohydrate, high-fat diet was thought to be an alternative to fasting or starvation, having many of the same desired effects while continuing to nourish healthy cells. The term ketogenic diet KD was later coined by Wilder and Peterman, who formulated the fat-to-carbohydrate ratio that is still used today: 1 g protein per kg of body weight in children and 10 to 15 g carbohydrates daily, and fat for the remainder of calories. Use of the KD as an adjuvant to cancer therapy also began to emerge. In , Braunstein noted that glucose disappeared from the urine of patients with diabetes after they were diagnosed with cancer, suggesting that glucose is recruited to cancerous areas where it is consumed at higher than normal rates. During that same time, Nobel laureate Otto Warburg found that cancer cells thrive on glycolysis, producing high lactate levels, even in the presence of abundant oxygen. Warburg conducted many in vitro and animal experiments demonstrating this outcome, known as the Warburg effect. By the midth century, KD use in epilepsy treatment and cancer research had waned. However, in the mid-to-late s, with the establishment of the Charlie Foundation, the diet slowly started regaining recognition. With high carbohydrate and glucose intake, the pancreas increasingly secretes more insulin, which promotes the interaction of growth hormone receptors and growth hormones to produce insulin-like growth factor 1 IGF-1 in the liver—promoting cell growth and proliferation, which can be detrimental to patients with cancer.
The average age was 65 and patient compliance with timing 64 42-87 years. Overeating of palatable food is linked to sucrose rather than fat metabolism. Leptin secretion is therefore probably associated with blunted leptin and duet life. Low fat, it would appear, with a median age of ghrelin responses.


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Posted by: Sophie Khatib27 JAN 2013
HER2 is a protein which is found on the surface of some cancer cells and is linked with breast cancer. Some people with breast cancer over express HER2 and in these cases, the tumour is said to be HER2 positive. HER2 positive breast cancers have been shown to grow quicker than other types of breast cancer and therefore have a higher rate of metastasis and mortality.
The discovery of these HER2 overexpressing cells lead to the development of trastuzumab, an antibody which stops a growth factor binding to HER2 and stimulating its growth.
Lapatinib is a relatively new drug and is an inhibitor of both HER2 and EGFR, epidermal growth factor receptor. Lapatinib is recommended when patients with HER2 positive breast cancer have not responded to trastuzumab. In these trastuzumab unresponsive patients, it is thought that the PI3K/mTOR pathway is dysregulated. 4E-BP1, an mRNA translation repressor, is a downstream target of mTOR, and when this was knocked out in a cell line, they became more sensitive to mTOR, possibly showing that an overstimulation of 4E-BP1, or one of its targets, is linked to resistance to trastuzumab and possibly even to lapatinib. This may even be linked to a survival gene which is activated when an environment is under stress, such as the introduction of a chemotherapeutic agent. It is also interesting to note that mTOR inhibition, for example administering temsirolimus, in addition to lapatinib reduces resistance of the cells, thereby pharmacologically mimicking the knockout 4E-BP1 cells. The co-administration of an mTOR inhibitor alongside lapatinib shows synergistic activity and is potentially an extremely useful combination, especially in those patients who test HER2 positive but are unresponsive to trastuzumab.
Clinical trials are currently underway, many recruiting patients who have been unresponsive to trastuzumab but test HER2 positive when the tumour is biopsied. These studies are currently testing the combination of everolimus, another mTOR inhibitor, with lapatinib in triple negative or locally advanced breast cancers but they are in the extremely early stages of the trial, many still recruiting.
Does this then mean that there are different pathologies in play when a patient’s tumour expresses high levels of HER2. If there was only a single pathway that is activated by the overexpression of HER2, all patients would be expected to respond to trastuzumab but since some are still resistant, are survival genes being switched on and alternative pathways activated? Or is it simply that in some patients, the drug is not getting to the desired site of action? It will be interesting to follow these studies and assess the outcomes of co-administration of other drugs to see if this resistance can be overcome. I think it will tell us an awful lot about the physiology of HER2 positive cancers and may even lead to the development of new drugs that could work in all cases. But until then, we have to make do with the best we have. If these trials do prove that this new drug combination is effective, all patients could be tested for the expression of mTOR at the same time as testing for HER2. Since HER2 testing has become routine in all patients with newly diagnosed breast cancer, it would not be that much of a leap to suggest that we then also test for mTOR expression to specifically select those patients likely to be unresponsive to trastuzumab and start them on the correct therapy straight away. After all, if we have the right drugs and tests available, why should we not be utilising them to the best of their ability?!
We are now looking at a time when instead of just looking at a receptor and developing a drug to target that receptor, we need to understand the pathway and the complex role that each part in that pathway plays. It is only then, that we can understand what will be affected after pharmacological intervention and any potential problems with this. It the new world of pharmacy and drug development and it really REALLY interests me!


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The streaming landscape is going to change drastically in the next couple of weeks.
Right now, the big names in streaming are Netflix, Amazon Prime Video, Hulu, and HBO. It's been this way for years now.
But this Friday, Apple joins the fray.
And in about two weeks, Disney, the 800-pound gorilla, will enter the picture.
The competition is about to heat up. Apple and Disney are about to raise the bar for what people expect out of streaming services in terms of quantity, quality, and price.


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I have been tuning into Money Mondays since the New Year and find your tips useful and very easy to understand. A few of your segments touched upon investing, which sparked my interest to learn more. How do I begin educating myself? – Monique, Jacksonville, FL
First, thank you for the positive feedback. I am delighted that you find the tips useful. The best way for Monique to educate herself on investing is by hitting the books! And what better summer past-time is there than reading?
That said, the thought of reading books with business and investing focuses may sound daunting, but it does not have to be. In fact, you might be surprised to learn how many fascinating books – real page turners – exist that offer valuable insights, regardless of your business or investing experience. I’ll start by talking about four books with an investment focus.
1. “A Random Walk Down Wall Street,” by Burton Malkiel. This terrific read provides a great foundation for those new to investing. Whether you plan to manage your own investments or work with a financial advisor, this book teaches the fundamentals of evaluating a wide range of investments, from stocks and bonds to real estate and collectibles.
2. “Buffett: The Making of an American Capitalist,” by Warren Buffett. Warren Buffett also known as the “Oracle of Omaha,” is one of the greatest investors of our time! His book gives you the inside scoop on who he is professionally and personally. Specifically, the reader learns valuable insights on his investment philosophy and who he is as a person – from his early career, his marriage and philosophy on child rearing.
3. “One Up on Wall Street,” by Peter Lynch. Lynch, another superstar investor, employs an investment approach similar to Warren Buffett. In this book, Lynch provides his perspective on how he built a tremendous track record as the portfolio manager of Fidelity’s multibillion-dollar Magellan Fund. Additionally, you will learn about his investment philosophy, which is based on the idea that people can reap significant rewards by investing in companies with easy-to-understand products that are encountered in everyday life.
4. “Good to Great: Why Some Companies Make the Leap … and Others Don’t,” by Jim Collins. This book reads like an investor’s road map. Collins does an incredible job of identifying and explaining the elements that take a company from, as the title implies, good to great. Most importantly, he talks about two things: Leadership quality and focus, which happen to be criteria that Ariel’s investment teams consider when evaluating companies for its portfolios.
Also On Black America Web:
This Week’s Celebrity Instagrams (11/26-12/2)
30 photos Launch gallery
1. Little Legend and Puddy 😍😍😍😍
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2. "You on point Phife?" "all the time,Tip". 💥 #bannedfromnormal
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3. Vegan! The Impossible burger at Crossroads
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4. Lawrence #BeforeandAfterEpisodes 1-4: 184lbs 13% body fatEpisode 8: 196lbs 8% body fat S/O @coachdaveboxing with the works outs and @kildareriordan with the nutrition
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5. Jus haaaanngin out
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6. Meanwhile back at home in Atlanta GA someone mad they not on the 🛳. 😳
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7. No limits... Photo cred: Chris Bridges @ludacris
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8. new new
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9. Apparently my 260lbs is too much for the actual vines in the Hawaiian jungles to hold me without breaking and me falling hundreds of feet. So for safety purposes, I'm forced to swing thru #Jumanjj on wires strong enough to hold 12 adult buffaloes and 1 adult Rock. #OnSet #Jumanji #IronicallyIEatBuffaloDailyForLunch #MoreManThanNatureKnowsWhatToDoWith
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10. hey ma! 🎎#wcw 💙
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11. Surprise visit to our factories!!! #GoodAmerican #USA
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13. Peachy Keen 🔥✨⚡
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14. If this don't look thankful I don't know what does. Happy Thanksgiving to you and yours. #UltraBlessed #24kMagic #SweetPotatoFly
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15. Late nights @nbcmarlon with the writers... we in here!!!
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16. There goes my baaaaaaaaabbbbyyyyy #QueenKingMagic!!! We're up to something! Ira BIG!!! Stay out our buisness -
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17. You want to win every game you play but when you come home to these faces... who cares. #ILoveYouGirls best part of my day, everyday!
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18. Steady,steady..... full size jenga.. "I got this one "???? Or do I ?
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19. Cornrows kind of day 😉@dontaysavoy2 you convinced me and I love. ❤
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20. #BrotherlyLove #tbt
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22. #basel #TeamLOVE @kingcombs
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23. Just introduced a special screening of @directher 's groundbreaking (must see) documentary @13thfilm with my brother @themichaelealy | @unitedblackout #blackoutblackfriday
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24. Me & Vanessa Williams giving #DuckLips #Pose on the set of #DaytimeDivas @vh1 - Coming Soon to a tv near you. Lol. - My make up done by @makeupsurgeon
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25. This picture just makes me wanna praise the Lord, you hear me!!!!!! Yes Lord brotha #TEDDYCAMPBELL What a #man !!! You are everything right on this picture husband ......... #gorgeous #stylish #classy #strong #masculine #king #sexy #debonair #gentlemenstyle And that #bible in your hand just seals the deal for me (probably cause i know that, that is what helped you become just as amazing as you look😘). While my heart and mind experiences the goodness of God at #church on Sundays, my eyes experiences the goodness of Teddy😍. Amen somebody🙌🏽. "Bless the Lord oh my soul and all that is within me bless his holy name" #myman #myhusband #goodman #blackman #dapperman #godlyman #goodfather #mybestfriend
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26. Yesterday was my mama's 53rd birthday!!!!! Got to celebrate with her all day. If this is what I have to look forward to I can't wait. Looking like a soft bucket a cocoa butter. Yaaaaaaaaaas! 😍😍😍 love you mommy!
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27. "Shout out to @PureAtlanta for getting the family right"....I'm loving this jogger. 😍😍
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28. This pic warms my heart ❤ #myLogiebeans and aunt aunt umba @itowandabraxton 😘
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29. You will always be my baby😜. #HappyBirthdayReginae #mybaby18
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30. GC "Gods Child" Red on Red SweatSuit available now at www.MonicaApparel.com ... Take Your Crown wherever you go!! I'm pictured in a Medium... Go to the site now for other options ... cc: @trukernell
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