text:
One of the nice beanies of the Avios/BA Scheme is the European (Zone 1 – Zone 3) flights costing a pittance.
Currently a one way flight (providing saver award availability exists) costs:
- EuroTraveller from 4500 Avios + £27 taxes and fees
- Club Europe from 9000 Avios + £34 taxes and fees
These prices head up as follows:
- Economy From £27 to £30 + Avios
- World Traveller Plus From £30 to £35 + Avios
- Club Europe/Club World From £34 to £40 + Avios
- First From £40 to £45 + Avios
World Traveller Plus and First avalible on London <> Moscow DME route only operated by BA. Reward saver flights fees on Comair remain as is.
This represents a rise of £3 to £6 depending on class of travel – with the blame being levelled on APD that went up earlier this year.
Reward saver can represent good value against bottom of the bucket Economy/Club Europe redemptions in terms of cost (least of all, by the time you bundle tax, fuel surcharge and APD together, it’s normally the majority of the fare with the actual fare costing a few pounds at most).
You’ve got until the 7th October to book at the old rates. From the 8th October, the new rates apply.
Avios.com has a breakdown on the possible savings.
To be honest, I’m surprised it has taken them this long to raise the prices. It’s still a bargain compared to the cost of some ET/CE flights though and shouldn’t be dismissed out of hand.

domain: travel


text:
For the first time in the 14-year history of the International Venice Biennale of Architecture, the Nunavut flag flew at the entrance to the Canadian Pavilion, an Inukshuk floating at the entrance of “Arctic Adaptations: Nunavut at 15.”
The exhibit, curated by architects Lola Sheppard and Mason White, from Toronto-based design firm Lateral Office, coincides with the 15th anniversary of the territory’s creation. — indiancountrytodaymedianetwork.com
Bracket [Goes Soft] Toronto book launch will be hosted by creatures:collective on March 1st, starting at 7pm. Editors Lola Sheppard and Neeraj Bhatia will launch the book, which will be available for purchase.
Edited by Neeraj Bhatia and Lola Sheppard of Infranet Lab, this second volume in the impressive [bracket] series “examines the use and implications of soft today – from the scale of material innovation to territorial networks.”
Free and open to the public, no RSVP is required. — InfraNet Lab
SUBMIT NEWS: submit in 60 seconds!

domain: news


text:
Buy on Wanelo
$50 - $100
$100 - $500
$500 - $1000
Bohemian & Rustic
Surf & Skate
Vintage & Retro
Blingy Thingies ✨💍💎, Adventureous
Bracelets Type Bangles Fine or Fashion Fashion Setting Type Channel Setting Model Number Eagle Turquoise Brcelet Cuff Plating Antique Gold Plated Diameter 5.8cm Material Stone Style
Vintage Native American Navajo Sterling Silver Baskets Cuff Bracelet. This stunning Native American bracelet appears to be a collaboration between Navajo Ray Bennett, and Thomas Singer! The cuff itself is
jewelry, cute stuff
Vintage Native American Navajo Sterling Silver Turquoise & Red Coral Cuff Bracelet. A marvelous vintage cuff. The cuff has two nice bezel set turquoise stones and three
perfectgift, cdraper, sterlingcuff, bluegemturqoise, fabulous
Ladies this cuff is amazing, it is a smaller cuff and will pair well with your larger cuffs. The cuff is completely hand stamped by M&R Calladitto, Navajo. The piece
This is a smaller 1940's Navajo watch cuff that has been given a face lift by Vicki. She travels all over the world and finds Vintage Navajo pieces in the
Vicki Orr has created a gorgeous piece. She has taken a vintage Navajo Watch band and removed the watch face and replaced it with a 1943 Half Dollar. The cuff
Fantastic 6 stone vintage cuff, ladies this is truly a statement piece. The large cuff will stand out and have everyone ooohing and awwwing over your Vintage Cuff. The piece
Ladies this is a huge cuff. The cuff is a 1940's Vintage Navajo Watchband that has been revamped. Out with the old and in with the new is exactly what
This large Vintage Navajo Cuff features amazing Green Kingman Turquoise stones and Kingman Coral stones. The cuff is a Vintage 1940's watch cuff and Vicki has taken and added a
This is a great vintage cuff, it is a 1930's sterling silver Navajo watch cuff that features hand stamping on the edge of the cuff as well as 1 Coral
This is a great 1940's Vintage Navajo Watchband that Vicki Orr has found during her travels. Vicki has taken a Silver One Dollar coin and replaced the watch face give
Vintage Native American Navajo J. Nelson Sterling MOP Cuff Bracelet Navajo Native American silversmith and lapidary artist, John Nelson, handcrafted this incredible cuff bracelet. The gorgeous pale pink focal is
Vintage Signed Native American Navajo Huge Sterling Silver Coral Large Cuff Bracelet This outstanding Native American Navajo cuff features 37 glorious specimens of old red Mediterranean Coral, set in a
Vintage Signed Navajo Sterling Silver Turquoise Child Baby Cuff Bracelet. The cutest little bracelet. Made for a baby or child, Solid .925 sterling silver and genuine Turquoise. Signed W.T. and
Bracelets Type: Bangles Model Number: Eagle Turquoise Brcelet Cuff Plating: Antique Gold Plated Metals Type: Zinc Alloy Brand Name: RechicGu Style: Vintage Place of Origin: Hong Kong Metals Type: Gold
Vintage Jewelry: Vintage Sterling Silver Thick Stamped Southwestern Bracelet with Center Oval Turquoise stone, bezel set, signed Tahe Sterling. It has an inside measurement of 6.75 (including opening at back).
My Etsy Shop
Late 1800s to early 1900's Navajo silver cuff Excellent antique condition. Unsigned. Guaranteed to be coin silver or better, 90% or more. Hammered design with great spirit and peace symbols.
Silver and Turquoise Navajo Cuff Vintage 1970s pawn silver and turquoise Navajo cuff. 3.5" 1"
Vintage Handmade Navajo Sterling Silver Watch Cuff The bracelet is in excellent vintage condition with a nice even patina. The cuff has never held a watch before. End to end
Vintage Southwestern/Navajo Sterling Silver Old Pawn Turquoise Cuff Bracelet. The inside measurement is 6.5" and weight is 87.27 grams - heavy. It is 1.75" from front to make and
stockingstuffer, christmasforhim, forhim
Vintage Sterling Silver & Gemstone Jewelry
Thank you for shopping small with me, Plating: Antique Silver Plated Diameter: 6.1cm (2.4") Arrow Gemstone : 6.5cm x 3.3cm x 1.5cm (2.6"x1.3"x0.6")
This amazing tufa cast bracelet is sterling silver. It features a natural 17x13mm turquoise stone. This bracelet measures 1 inch wide and is done in the traditional "sweater" cuff style.
This beautiful cuff bracelet is made to hold a watch face. Hallmarks: 925 Measurements: 38mm or 1 1/2 inches thick! The inner circumference is 7 inches including a 1.5 inch
This stunning turquoise and coral bracelet is the creation of Navajo artist Randall Joe Tom. It features a beautiful, natural turquoise with carved bird tracks and genuine red coral. The
This beautiful Navajo cuff bracelet is sterling silver. It measures 13/16 of an inch wide. It has an inner circumference of 6.5 inches, including the 1 inch gap. Weight: 32
This gorgeous Denim Lapis cuff bracelet is the creation of talented Navajo silversmith Cathy Webster. The genuine denim lapis measures 12x17mm. The face of this bracelet measures 1 inch and
This gorgeous lapis cuff bracelet is sterling silver. Is the creation of Navajo silversmiths Edward and Patricia Becenti. This bracelet tapers from 5/8 to 3/8 of an inch wide. It
These gorgeous bracelets are a matching set and fit together perfectly. The smaller bracelet features a diamond shaped focal inlaid with lapis, opal and jet. The face of this bracelet
This amazing Inlaid cuff bracelet is sterling silver. It features intricate inlay in jet, coral, 5 different types of natural turquoise and different colors of spiny oyster. This bracelet measures
This gorgeous vintage cuff bracelet is sterling silver. It measures 3/4 of an inch wide. It has an inner circumference of 6 3/4 inches, including the 1 1/4 inch gap.
This gorgeous Navajo cuff bracelet is the creation of Franklin Tahe or his wife Verna, or possibly both as they collaborated on many pieces together. This bracelet measures 5mm wide
This stunning, massive cuff bracelet is a one of a kind custom creation by the talented William Vandever. Its sterling silver with a 14k yellow gold feather and 4 beautiful
This gorgeous vintage sterling silver cuff bracelet is the creation of Navajo silversmith Clayton Tom. It features a micro inlay bird in coral, turquoise, jet, mother of pearl and abalone.
This gorgeous cuff bracelet is sterling silver. It features a raised inlay design in white mother of pearl, lapis lazuli, turquoise, jet, coral, yellow mother of pearl and malachite. This
This gorgeous bracelet certainly makes a statement!! Measurements: 9x28mm oval Onyx gemstone. The face of the bracelet is 1.5 inches at its widest. The cuff band is 5mm at its
This gorgeous vintage Navajo cuff bracelet is sterling silver. It features raised, cobblestone cut inlay in opal, coral, jet, dark mother of pearl, purple spiny oyster and sleeping beauty turquoise.
This gorgeous cuff bracelet is sterling silver. It is the creation of Navajo silversmith Herman Coan. It features inlay in lapis lazuli, pink and white shell. This bracelet measures 3/4
This beautiful sterling silver cuff bracelet features needlepoint coral gemstones. It measures 7/8 of an inch wide and has an inner circumference of 6.5 inches, including the 1 inch gap.
This beautiful inlaid cuff bracelet is the creation of the talented Navajo silversmith Ella Cowboy. It features inlay in lapis, pinky spiny oyster, jet, 2 different types of turquoise and
This gorgeous bracelet is hallmarked: Sterling, TAHE. It was made by Franklin Tahe or his wife Verna, or possibly both as they collaborated on many pieces together. The bracelet is
This gorgeous sandcast cuff bracelet features a beautiful 10x12mm blue turquoise gemstone. The face of this bracelet measures 13/16ths of an inch and tapers down to 5/16ths of an inch.
This gorgeous Navajo bracelet is an unsigned beauty. It measures 7/16 of an inch wide and has an inner circumference of 6 inches, including a 1 1/8 inch gap. This
This gorgeous cobblestone bracelet is a creation of the talented Navajo silversmith Brian Brown. It features inlay in orange and purple spiny oyster. This bracelet measures 9/16ths of an inch
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domain: artistic


text:
About Tzu Chi
Buddhist Tzu Chi Foundation is an international humanitarian organization in Special Consultative Status with the United Nations Economic and Social Council (UN ECOSOC). The foundation focuses on four major missions: charity, medicine, education, and humanistic culture. The foundation also engages in international disaster relief, bone marrow donation, community volunteerism, and environmental protection. “Tzu Chi” means “compassion and relief.”
Buddhist Tzu Chi Foundation was established in 1966 in Hualien by Venerable Dharma Master Cheng Yen. From the first 30 supporters, housewives who saved two cents from their grocery money each day to help the poor, the foundation has grown to nearly 10 million volunteers and supporters in 50 countries, and has provided international relief work in 70 countries to people suffering from disasters such as the Southeast Asia tsunami, Myanmar cyclone, and earthquakes in Turkey, Pakistan, Sichuan China, Haiti and Chile.
Dharma Master Cheng Yen founded the Buddhist Tzu Chi Foundation in 1966, at the age of 29. She deeply believes that all people are capable of the same great compassion as the Buddha. True compassion, however, is not just having sympathy for another’s suffering—it is to reach out to relieve that suffering with concrete actions. In founding Tzu Chi, Dharma Master Cheng Yen wished to give ordinary citizens the chance to actualize this compassion, which will bring inner peace and happiness to the individual, and pave the way for world peace and harmony. In 2011, TIME Magazine named Dharma Master Cheng Yen to the 2011 TIME 100, the magazine’s annual list of the 100 most influential people in the world.
About Tzu Chi USA
In 1984, Buddhist Tzu Chi Foundation in the U.S. registered as a non-profit 501(c)(3) organization in California. In 1989, the first office in the U.S. was established in Alhambra, California. There are now more than 80 offices and facilities in the U.S. with over 100,000 volunteers and donors working to make a difference in their local communities.
Tzu Chi U.S.A. has more than 20 community programs. Volunteers are active in programs such as family services, services to the homeless, visits to senior homes, medical and dental services, recycling, and reading to children. Tzu Chi U.S.A. also works with neighborhood schools and organizations such as the Foothill Unity Center and the Center for the Pacific Asian Family in Los Angeles, the Habitat for Humanity in Dallas, and the Ronald McDonald House in Minneapolis, Los Angeles, Pasadena, Falls Church, Baltimore, and Washington DC.
Tzu Chi’s unique approach to disaster relief includes delivering cash aid and emergency relief supplies directly into the hands of disaster survivors. Wherever there is a disaster, Tzu Chi is ready to provide relief to all, regardless of nationality, ethnicity, socio-economic status or religion. The guiding principles of Tzu Chi’s relief work are “gratitude, respect and love.” This is why Tzu Chi volunteers deliver relief supplies and cash aid to disaster survivors with both hands, a smile and a bow or a hug.
Tzu Chi U.S.A. was the first organization to provide immediate cash aid to affected families within days after the attacks on September 11, 2001, in New York City. Families received up to a thousand dollars each. In all, Tzu Chi gave two million dollars to 3,164 families.
In 2005, after Hurricane Katrina struck several states, Tzu Chi U.S.A. mobilized over 1,000 volunteers to distribute emergency cash worth 4.12 million dollars to 22,487 households, or over 58,553 people. A fundraising campaign was held in more than 30 countries to raise funds to assist the disaster survivors.
In January 2010, Haiti suffered from a devastating earthquake. From January to the end of May, teams of Tzu Chi volunteers and medical personnel from the U.S. traveled to Haiti continuously and worked with Tzu Chi Haitian volunteers to provide immediate relief. Tarps, food and other supplies were delivered to 47,202 households, or nearly 199,176 people. Tzu Chi medical personnel provided medical and dental services to over 15,200 patients, and through Tzu Chi’s Food for Work program, 3,770 Haitians worked together to clean their neighborhood.
On June 18, 2008, representatives from the American Red Cross and the Tzu Chi Foundation signed a memorandum of understanding at the Tzu Chi Humanities Center in Taipei. The two organizations will combine their respective strengths and cooperate in disaster relief operations, emergency preparedness and response, cross training, and other cooperative actions in the United States.
Tzu Chi is now a member of National Voluntary Organizations Active in Disaster (National VOAD) and InterAction. In 2010, Tzu Chi was granted special consultative status with the United Nations Economic and Social Council (UN ECOSOC).

domain: sociology


text:
JoinME emerged victorious at the 2023 Cannabis Start-Up Competition, grabbing the grand prize of $10,000. The event unfolded on the evening of November 7, 2023, at The Rajen Kilachand Center for Integrated Life Sciences and Engineering in front of a packed house.
Hosted by Innovate@BU and Green Lion Partners, the competition is a hallmark event for ancillary cannabis companies with a BU student or alum at the helm. JoinME, co-founded by Marco Rotella (Questrom’22) and Claudio Bettini (COM’23), distinguished itself among the four finalists with its mission to foster a healthier and more inclusive cannabis consumption culture.
Esteemed judges, including Jaime Lewis, a veteran in medical marijuana dispensary operations; Kim Napoli, Director of Diversity, Equity, and Inclusion at Vicente Sederberg LLP; and Dr. Peter R von Bleyleben, Partner at Converge Venture Partners, provided their expertise. The judging panel, with substantial experience across cannabis industry leadership, consulting, and advisory roles, had the challenging task of selecting a winner among the remarkable pitches of the evening.
The finalists, which also included GreenCloud, IPNPC, and Smoking.com, presented their forward-thinking solutions aimed at optimizing operations, promoting sustainability, and enhancing consumer experiences.
As the event concluded, attendees engaged in a networking reception, reflecting on the innovative ideas that had been shared. The JoinME team now looks forward to utilizing its prize to further its goal of connecting individuals in the cannabis community.


text:
The Wera 32 Piece Kraftform Kompact 70 Set is highly versatile and portable. It comes with Kraftform multi component handle, that is comfortable to use. It also has a non-roll feature meaning it will not slip in hand and a Rapidaptor quick-release chuck for effortless bit change.
1 x 816 R Bitholding Screwdriver with Rapidaptor Quick-Release Chuck.
1 x 1/4in 889/4/1 K Rapidaptor Universal Bit Holder.
9 x 25mm Phillips Bits: PH1(3), PH2(3) & PH3(3).
9 x 25mm Pozidriv Bits: PZ1(3), PZ2(3) & PZ3(3).
6 x 25mm Torx Bits: TX10, TX15, TX20, TX25, TX30 & TX40.
3 x 25mm Slotted Bits: 0.6x4.5mm, 1.0x5.5mm & 1.2x6.5mm.
3 x 25mm Hex-Plus Bits: 4.0mm, 5.0mm & 6.0mm.
- Additional Information
Condition New SKU PTDWER057110 Weight (Kg) 0.4700 Brand Wera Manufacturers Part Number 05057110001 Retailer Barcode 4013288038654 Package Height (cm) 11.2 Package Width (cm) 4.2 Package Length (cm) 18 Bullet 1 Proven reliable Wera technology Bullet 2 Lightweight construction at just 0.47 Kgs Bullet 3 High performace for the home or tradesman Bullet 4 N/A Bullet 5 N/A Bullet 6 N/A

domain: hobby


U.S. Rep. Gwen Graham defended extended benefits given to veterans under the so-called Post-9/11 GI Bill in a rally with Iraq and Afghanistan Veterans of America and allied veterans groups Thursday afternoon in Washington, D.C.
The first-term Democrat from Tallahassee said the bill’s enhanced educational and career benefits should not be sacrificed in favor of cost-cutting measures floated by some in Congress.
“Our country made a promise to our veterans that we’d support them when they came home from war – and now Congress needs to keep that commitment,” Graham at press conference in front of the U.S. Capitol.
“Our veterans and their families make great sacrifices fighting for our freedom. I’m committed to fighting for them once they come home. Congress should focus on cutting waste, fraud and abuse – not balancing our budget on the backs of the men and women who serve in uniform,” said Graham.
Among the supporters of the legislation joining Graham was IAVA Founder and CEO Paul Rieckhoff, who also spoke from the podium to reporters.
“The fact that we even have to fight to protect this critical earned benefit that has empowered so many Iraq and Afghanistan veterans and their families is beyond disappointing,” said Rieckhoff, himself a veteran of the Iraq War. “The Post-9/11 GI Bill has created unparalleled educational and career opportunities for the nearly one million veterans who took advantage of it after service to our country.
“Veterans will not sit idly by while Members of Congress use the benefits we’ve earned as a piggy-bank for other programs,” Rieckhof said, saying his group was 425,000 members strong.
Cuts to the bill’s provisions were quietly made in an omnibus veterans bill passed by the House in February.
Also flanking the veterans in support of the enhanced benefits were U.S. Rep. Seth Moulton, Tim Walz, Tulsi Gabbard, Tammy Duckworth, Brad Ashford and Kathleen Rice, all Democrats.


text:
The Canadian government says it will impose a 25 per cent surtax on some foreign steel products in a bid to head off dumping.
The Finance Department said “excessive imports” are harming the steel industry, prompting it to impose a surtax on seven products that range from rebar to wire rods.
The surtax, which begins Oct. 25, will be in place for 200 days, pending an inquiry by the Canadian International Trade Tribunal into whether longer-lasting safeguards are necessary, the government said.
The announcement comes more than three months after Canada imposed tariffs on $16.6 billion worth of American goods in retaliation for hefty U.S. tariffs on Canadian steel and aluminum.
The government also announced Thursday that some Canadian manufacturers can now import those products from the U.S. without paying the surtaxes that have applied since July 1. A portion of the relief will be temporary, offered until Canadian producers are able to adequately meet domestic demand.
The exemption applies on a case-by-case basis to companies that applied for it, and pertains to American steel, aluminum and certain other products.
The products affected by the fresh tariffs go into structures from condominiums to dams and bridges, “which encompasses a heck of a lot of steel,” said Jesse Goldman, a lawyer representing the Canadian Coalition for Construction Steel.
He said the surtax puts the construction steel industry in “a very dire position” because of Canada’s limited domestic steel supply.
“Because of the actual quota amounts for this type of steel from non-U.S. sources, U.S. steel is going to come into Canada at record high prices. They will simply pass on the 25 per cent retaliatory tariffs to their Canadian customers.”
The surtax on steel plates and other products could “jeopardize” mega-projects in Newfoundland, which relies almost exclusively on foreign steel, primarily from Europe, Goldman said.
A lot of imported structural steel has been put toward the refurbishment of the Parliament buildings, he added. “It’s more ironic than intentional, but it gives you an example of the importance of imported steel in Canada.”
The country’s geography deters West Coast buyers from purchasing from central Canadian mills. It costs more than four times extra to ship a tonne of steel to Vancouver from Ontario than it does from China or Korea, said Richard Lyall, president of the Residential Construction Council of Ontario.
With rebar an essential component in residential towers, the new steel tariff could boost the price of new condos in Vancouver by up to $10,000 per unit, Lyall said.
“Housing affordability got thrown under the bus on this one,” he said.
Finance Minister Bill Morneau is slated to address the Commons international trade committee Tuesday on its study of how tariffs are impacting Canadian businesses and workers.
MORNEAU’S FIRST ANNOUNCEMENT RE SAFEGUARDS
Finance Minister Bill Morneau will impose immediate global tariffs and quotas designed to deflect a damaging flood of steel imports into Canadian markets as a result of U.S. levies.
The “provisional safeguard” measures on seven steel products — considered emergency actions by the World Trade Organization — will apply to all countries including China, but will provide specific exemptions for the United States, Mexico and developing countries.
The government will also provide relief in the form of refunds on import tariffs paid on imported U.S. steel and aluminum products that are in short supply in Canada.
“This is an adjustment mechanism giving the industry time to take a breather and deal with the surge of imports into this country,” said Lawrence Herman, an international trade lawyer at Herman and Associates, who is representing smaller steel firms involved in the issue. “Steel was flowing into Canada, there was a need for the government to take action.”
The safeguards are intended to prevent a damaging surge in imports by establishing a ceiling on the amount of each product allowed into the country under standard duties — set at the average of the past three years of import volumes. All imports exceeding that amount will face a tariff of 25 per cent.
The measures come into force on Oct. 25 and will remain in place for 200 days pending a full independent review of the evidence by the Canadian International Trade Tribunal (CITT) — the quasi-judicial body tasked with making a final recommendation to Morneau on whether the evidence warrants “final safeguards” that would last for three years.
The seven products affected are concrete reinforcing bar, steel plate, hot-rolled sheet used in auto manufacturing, energy tubular products, pre-painted steel, stainless steel and wire rod.
Canada is currently negotiating with the U.S. to remove tariffs of 25 per cent on steel and 10 per cent on aluminum imposed in June. Though U.S. President Donald Trump had said the removal of those tariffs was contingent on the revamping of NAFTA, he has yet to lift them following the announcement of the new U.S.-Mexico-Canada trade agreement last week. Canada currently has retaliatory tariffs in place on $16 billion worth of U.S. steel and other products.
The U.S. is exempted from the safeguard measures because it is already subject to retaliatory tariffs, the Finance Ministry said in a release. Imports from the U.S. were also found to have not “contributed importantly” to injury or threat of injury to the market, the release states. All imports from Mexico — with the exception of energy tubular and wire rod products — will also be excluded, as they don’t represent a significant share of imports.
The safeguard announcement prompted immediate concerns about potential supply shortages. A coalition of construction companies, called the Canadian Coalition for Construction Steel, previously warned that the Canadian industry cannot produce enough steel to supply the market and domestic steelmakers simply don’t make some products they require. Restricting the supply of those products could prompt a hike in prices that won’t be compensated by tariff refunds, they cautioned yesterday.
“My clients are very disappointed and feel like their concerns haven’t penetrated the government and were sacrificed to the interests of the Canadian steel industry,” Jesse Goldman, a partner at Borden Ladner Gervais LLP, representing the coalition. “Cutting off third-country imports will create a shortage, which means importers will be desperate for steel. This is a blank cheque for U.S. and Canadian steel producers to raise prices and we expect they will do so immediately.”
… the Canadian industry cannot produce enough steel to supply the market
and domestic steelmakers simply don’t make some products required
“The Government recognizes that Canadian countermeasures against U.S. imports can create challenges for Canadian manufacturers that rely on steel and aluminum imported from the U.S.,” the Finance Department said in a statement.
In August, Morneau launched a 15-day public consultation process on possible safeguards, saying increases in imports had been detected. The European Union imposed provisional tariff rate quotas in July citing evidence that steel was being diverted into its markets as a result of U.S. tariffs. The EU tariffs on 23 steel products are also set at the average of imports over the past three years, with a 25 per cent tariff set for volumes exceeding those amounts.
“This is not a process that was undertaken capriciously or without evidence,” said Joe Galimberti, president of the Canadian Steel Producers Association. “The government was presented with evidence of a significant increase in import volumes and is proceeding with safeguards. Given the global climate, that is appropriate.”

domain: finance


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text:
"Hi." Brittany tugs at her own hair, golden locks sliding through her fingers.
Santana bites her lip and watches the other girl for a moment. They’ve just finished their Sectionals performance, and Santana is still running high on adrenaline. She takes a deep breath.
"That was for you," she says quietly, carefully gauging Brittany’s reaction. "The song. It’s stupid but I sang it for you. I know you’re like, dating Artie now or whatever, but—"
"My name’s not Valerie," Brittany cuts in, her voice hitching. She sounds surprised, but more than that, she sounds like she understands.
Santana looks down and fiddles with the fabric of her dress. “I just wanted—I don’t know.” Her cheeks burn, and her chest aches inexplicably. “Forget it,” she backtracks, trying for a smile. “You were totally awesome out there, Britt.”
Brittany beams. “So were you.” Her features soften, suddenly, and she pushes herself up, leaning in to brush a kiss across Santana’s cheek. “Thank you.” Quieter still, whispered against the shell of Santana’s ear: “I love you. Don’t forget.”
Santana’s heart beats steady as she rises and pulls Brittany into a tight embrace. I won’t and me too carry into her limbs as she holds her.


Atomic absorption spectrophotometry analyzes the concentration of elements in a liquid sample based on energy absorbed from certain wavelengths of light (usually 190 to 900 nm). Atomic absorption spectrophotometers typically include a flame burner to atomize the sample (most commonly a hollow cathode lamp), a monochromator and a photon detector. Depending on the model, some atomic absorption spectrometers are equipped with a turret or fixed lamp socket that can hold multiple lamps (up to eight) to reduce downtime between samples or allow for sequential analysis.
Atomic absorption spectrometers are used in the pharmaceutical industry during drug development. In atomic absorption spectrometry, a sample is atomized, usually by a flame or graphite furnace, and dispersed into the light. A detector measures the amount of absorption in the sample and compares it to a reference with a known concentration of the element in question to determine its concentration in the sample. Some of the specifications to be aware of before purchasing an atomic absorption spectrometer are its wavelength range, what type of atomizer it uses, if it can do multiple tests for multiple elements, and if it has a single beam, double beam or both types of light source.
AAS is also used in food and beverage, water, and clinical analysis. It is also used in mining operations, such as to determine the percentage of precious metal in rocks.


text:
Sector witnessed 14 per cent drop in exports last year.
A set of measures will be implemented this year to address agricultural marketing bottleneck and strengthen the resilience of the agriculture sector, which saw a 14 per cent drop in its exports last year, according to a senior government official.
The measures entail supporting farmers, launching government-based agricultural production projects, exploring new means and portals for exporting fruits and vegetables, modernising agricultural guidance and restructuring the ministry among other measures to recuperate agriculture in Jordan, Agriculture Minister Khaled Hneifat said.
The action plan seeks to stop the agricultural sector from a deterioration that started with the Syrian crisis in 2011 and worsened with the consecutive borders closures with Syria and Iraq, Hneifat said.
“There’s no country in the world suffering as much as Jordan does in terms of agricultural marketing congestion…, the regional turmoil post the Syria conflict has affected all the sectors, but agriculture was the most-hit by the regional instability because it is the most fragile sector,” Hneifat told The Jordan Times in a recent interview.
[Photo by Marc Veraart | Flickr]

domain: agronomy


text:
Please use this identifier to cite or link to this item: http://dx.doi.org/10.18419/opus-11653
|Title:||Metal-catalyzed formation of 3- and 4-membered rings|
|Abstract:||The catalytic activity of TBA[Fe] in the cyclopropanation of aryl olefins using diazo esters as carbene surrogates was investigated. By employing two modes of activation for the catalyst, i.e. thermal or photochemical, a variety of aryl olefins as well as 1,3-enynes were converted to the corresponding cyclopropanes in moderate trans-selectivity and good to excellent yields.The catalytic process exhibited good functional group tolerance and chemoselectivity, as triple bonds and non-conjugated olefins remained unaffected, and no competing X-H insertion reaction was observed. Mechanistic studies allowed to determine that the catalyst was activated by either photochemical or thermal decarbonylation. Moreover, the presence of 4-nitroanisole in sub-stoichiometric amounts was shown to accelerate decarbonylation of the catalyst under thermal conditions and enhance its activity. In addition, a novel silver-catalyzed oxidative ring expansion of propargyl cyclopropanes was developed to give a straightforward access to valuable synthetic intermediates. Enantiopure cyclobutenyl ketones were obtained from chiral cis-propargyl cyclopropanes under mild conditions with almost full retention of their enantiomeric excess and up to 92 % yield. The reaction exhibited so far good functional group tolerance and mechanistic investigations as well as expansion of the substrate scope are currently under way in our laboratories.|
|Appears in Collections:||03 Fakultät Chemie|
Files in This Item:
|Ph.D._Thesis_MIP_Final_OPUS.pdf||9,6 MB||Adobe PDF||View/Open|
Items in OPUS are protected by copyright, with all rights reserved, unless otherwise indicated.

domain: chemistry


text:
Initial Sjögren’s Symptoms May Predict Severity of Lung Complications, Study Suggests
Patients with primary Sjögren’s syndrome whose first symptoms are not mouth and eye dryness may experience more progressive and severe pulmonary manifestations during the course of their disease, a study reports.
Sjögren’s syndrome is an autoimmune disease characterized by the infiltration of immune cells into secretory glands — primarily the lacrimal and salivary glands. These cells incorrectly recognize the glands’ tissue as foreign and fight it, leading to cell death and reduced production of tears and saliva, resulting in dry eyes and dry mouth, or sicca.
In some patients, however, the disease may have manifestations outside the secretory glands and cause systemic symptoms, including lung disease.
Lung symptoms appear in anywhere between 9 and 75 percent of Sjögren’s patients, depending on the diagnostic tests used.
Because systemic symptoms are the main determinants of a patient’s prognosis, early detection and treatment of such complications are a major concern among physicians.
Researchers at the Peking University People’s Hospital in China set out to compare the frequency and severity of lung disease between patients with and without sicca at disease onset.
Among the 1,341 patients admitted to the hospital between 2003 and 2012, 853 had primary Sjögren’s syndrome and 488 had secondary Sjögren’s syndrome — meaning the disease was caused by another condition.
More patients with primary Sjögren’s had lung involvement than those with secondary disease — 25.8% versus 19.3%.
Investigators then examined the clinical records of 102 primary Sjögren’s syndrome patients, hospitalized between 2008 and 2012, and whose computed tomography scans were available for analysis. The majority of these patients were women (91.2 percent), with a mean age of 61 years.
Half of them experienced sicca as their first disease manifestation. The other half had pulmonary symptoms — such as shortness of breath or coughing — joint pain, fever, blood or vessel problems, teeth loss, rashes, parotid gland swelling, or liver damage.
While the mean time from the first symptom to diagnosis was similar, more patients with sicca were diagnosed with primary Sjögren’s syndrome at disease onset than those with other symptoms — 34% versus 4%.
Non-sicca patients required salivary gland biopsies or radiological examinations of the salivary glands more often than those with sicca at disease onset. They also required more lung biopsies and lavages.
Patients without initial sicca also had lower levels of globulin, a marker of liver function and inflammation, and anti-SSA and/or anti-SSB autoantibodies, as well as elevated rheumatoid factor.
Regarding pulmonary manifestations, interstitial pneumonia was more commonly seen in non-sicca patients. Their predicted total lung capacity and forced vital capacity — measures of lung function — were also lower than patients with initial sicca symptoms.
“Non-sicca is a common initial manifestation in primary Sjögren’s syndrome with ILD,” the researchers wrote. These patients are susceptible to “more progressive and severe” pulmonary complications than sicca patients.

domain: biology


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SPORT. Golbol is coming to Tokyo 2020 / @ CODESONoficial
The Paralympic Games taking place in Tokyo have stories that surprise every day, both for the athletes who are stars and for the sports they compete in.
Although it is held in almost the same facility as the one used for the 2020 Tokyo Olympics and the logistics are very similar, there are some notable differences between the two events.
In the Paralympics there are 22 sports, which is 11 fewer than in the Olympics, but they have more medal-winning events (540 against 339).
The medals are also somewhat different, the mascots are not the same and, above all, there are two sports that are exclusive to the Paralympics: boccia and goalscoring.
Both of these sports were created for people with mobility difficulties or are visually impaired, unlike other sports which are adaptations of those competed in the Olympics.
At BBC Mundo we explain the origins of these two sports that have starred in the Paralympic Games.
After World War II, hundreds of soldiers experienced vision problems after the conflict.
Around 1946, Hans Lorenzen from Austria and Sepp Reindle from Germany designed a game with the idea of rehabilitating these war veterans.
From there was born “goalball” or “golbol”, a sport consisting of two teams of three people each defending a goal that is about nine meters long.
The idea is to prevent the ball – which has a bell or chimes in it – from entering that arc and scoring.
All players have their eyes closed (to standardize the competition and avoid an advantage) and the idea is to use the whole body to cover the goal.
This is a highly physically demanding sport, as the most trained players can throw the ball at a speed of 70 km / h.
Due to its popularity, it was included as an exhibition sport at the 1976 Paralympics, and medals were awarded at the 1980 Olympics.
At the 2016 Rio Paralympics, gold medals went to the Lithuanian teams for men and Turkey for women.
Boccia is derived from the so-called game of bocce or petanque, which was very popular in Europe but was adapted into a Paralympic sport in 1984.
The idea of the game is to first throw a ball called the “target” or “target” and then throw another six red or blue balls, depending on the team.
Points are accumulated as far as the “target” is hit or the ball is placed as close to this target as possible.
To do this, the players, facing each other in two teams, have the option of rolling the ball, throwing it with their hands or kicking it. Also, in some cases they can use assistive devices to complete the launch.
Being a tactical game, some players can use an assistant to throw the ball for them.
Boccia – which comes from the Latin word bottia, meaning ball – was originally designed for people with severe cerebral palsy, but has since been expanded to other competitors with some physical disabilities.
At the Paralympics, prizes are awarded in three different categories: individuals, couples, or teams. And each of these categories has subdivisions depending on the mobility of the greater or lesser athlete.
Athletes from England and Thailand won gold medals at the 2016 Rio Paralympics.
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domain: game


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HemCon acquires Alltracel
This article was originally published in The Tan Sheet
Executive SummaryHemCon Medical Technologies completes its cash-for-stock takeover of Alltracel Pharmaceuticals, a Dublin, Ireland-based licensing and distribution firm specializing in cosmeceuticals, nutraceuticals and wound care markets, according to a May 14 release. The deal expands distribution opportunities for HemCon's chitosan-based bandage products used by military and medical first responders, the Portland, Ore.-based wound care firm says. The acquisition also gives HemCon access to Alltracel's nanotechnology-development joint venture with Elmarco and its proprietary Nanospider manufacturing process, which HemCon will leverage "to develop and aggressively grow its market share in acute wound care products," the firm says...
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Attorneys say Sarepta did not have an obligation to report its appeal, particularly since winning a formal dispute filing with the US FDA is a long shot.
Sarepta’s Vyondys: Renal Toxicity Concerns That Delayed Approval Get Enhanced Postmarketing Scrutiny, Label Warning
Sarepta must perform enhanced pharmacovigilance for serious renal toxicity events and rhabdomyolysis with the Duchenne muscular dystrophy drug, which carries a label warning for renal toxicity. Approval letter includes 2024 target completion date for ESSENCE confirmatory trial.
Efficacy data were striking to committee members, but they want to ensure postmarketing plans gather adequate data to address safety questions.


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Stricter impaired driving laws are set to come into force next week.
When Bill C-46 kicks in on Dec. 18, police will be able to demand a breathalyzer test from any driver pulled over for violating traffic laws or at a check stop.
Under the current law, officers must have reasonable grounds, such as bloodshot eyes, slurring, the smell of alcohol, a driver stumbling or admission of drinking, to suspect a driver is impaired to demand a breathalyzer test.
Under the new mandatory alcohol screening provisions, police will be able to demand a breath sample from a driver immediately, without having to have reasonable grounds to suspect the driver is impaired.
“The problem we face right now is many impaired drivers are not that easily detected and, in some instances, may not even show obvious signs of intoxication — at least while they’re sitting in the driver’s seat of their vehicle,” RCMP Supt. Gary Graham said at a news conference in Edmonton Monday. (CBC news)
Some lawyers have warned that the bill may violate charter protections against unreasonable searches and may be deemed unconstitutional by the courts.
The Senate amended the bill earlier this year to remove the provision allowing police to demand a breathalyzer test without reasonable grounds, but it was rejected by the House of Commons.
Earlier this month, Justice Minister Jody Wilson-Raybould conceded the law will likely be challenged in court, but said she is “100 per cent confident” it does not violate the Charter of Rights and Freedoms.
The government cites authorities in Ireland who credit mandatory screening laws for reducing the number of road deaths by roughly 40 per cent in the first four years after it was enacted in that country.
Services and information from Department of Justice Website
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Strengthening impaired driving laws to better protect the public from both alcohol- and drug-impaired driving.
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By Paul Mitchell, Pushor Mitchell LLP
- Corporations Canada will begin issuing Notices of Intent to Dissolve to CNCA non-profit corporations that have not filed their Annual Return in 3 years or more - May 30, 2023
- Why it is difficult to provide an estimate for legal services relating to ONCA transition or CNCA continuance for an existing non-profit or charity or registered charity - May 1, 2023
- Important new shift in Canadian privacy law: Legitimate interest exception to consent - April 28, 2023


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For Immediate Release
Office of the Press Secretary
September 12, 2008
President Bush to Welcome President Hamid Karzai of Afghanistan
The President will meet with Afghan President Hamid Karzai at the White House on September 26, 2008. The President looks forward to discussing with President Karzai the state of the international community's efforts to improve security, governance, and reconstruction in Afghanistan. The two leaders last met in Egypt in May during the President's visit to the Middle East. This meeting provides President Bush and President Karzai the opportunity to discuss security, the expansion of the Afghan National Army, the upcoming Strategic Partnership talks, and the implementation of political and economic reforms.
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domain: politics


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During primary contamination, murine cytomegalovirus (MCMV) spreads systemically, producing in computer virus replication and pathology in multiple organs. Salmefamol with its mammalian host over hundreds of thousands of years, providing a paradigm of a well-adapted prolonged computer virus that has been extensively exploited in studies of host-pathogen interactions in?vivo. MCMV also provides the most tractable in?vivo model for the pathogenic -herpesvirus human cytomegalovirus (HCMV), exhibiting many parallels in terms of pathogenesis, host immunity, immune evasion, and broad tissue tropism (Shellam et?al., 2006). NK cells are a key component of the innate immune response and are crucial for the control of human herpesviruses, a control that has been elegantly modeled in MCMV (Biron et?al., 1989; Bukowski et?al., 1984). Importantly, however, the antiviral role of NK cells can be both cell-type and organ specific. For example, NK cell depletion preferentially increases MCMV progeny derived from endothelial cells as likened with nonendothelial cell-derived pathogen, and this impact is certainly even more profound in the lung versus various other sites of infections (Sacher et?al., 2012). Furthermore, NK cells in the salivary gland, which represents a crucial site of MCMV dissemination and determination, are hyporesponsive to MCMV infections (Tessmer et?al., 2011). Research in MCMV also high light the crucial function for cytokines such as type I interferons (IFN), lymphotoxin, IL-12, and IL-18 in either suppressing virus-like duplication straight or controlling the advancement of natural and adaptive defenses (Andoniou et?al., 2005; Andrews et?al., 2003; Banking institutions et?al., 2005; Biron and Orange, 1996). Nevertheless, limited phrase of such cytokines in MCMV-infected tissue is certainly noticed (Schneider et?al., 2008). Jointly, these data are constant with the lifetime of extra antiviral effector systems that kitchen counter CMV Salmefamol in a wide range of cells within a variety of tissues microenvironments. Interleukin-22 (IL-22) is certainly an essential effector cytokine in peripheral tissue. IL-22 is certainly portrayed by many natural and adaptive resistant cells and indicators through the IL-22R/IL-10R dimeric receptor (Sonnenberg et?al., 2011). While IL-10R is certainly portrayed ubiquitously, IL-22R phrase is certainly limited to nonhematapoetic cells, with raised phrase Salmefamol in tissue such as the dental/gastrointestinal system, lung, epidermis, kidney, and liver organ (Wolk et?al., 2004). IL-22 contributes to the resistant control of gram-negative bacterial infections at mucosal surfaces while also exhibiting tissue-protective functions (Aujla et?al., 2008; Zenewicz et?al., 2007; Zheng et?al., 2008). The role of IL-22 in viral infections is usually less well defined. IL-22 neutralization does not impair protection from influenza contamination in mice (Guo and Topham, 2010) and, in Salmefamol certain viral contamination models, can heighten inflammation without influencing computer virus clearance (Zhang et?al., 2011). In contrast, IL-22 is usually cytoprotective in the liver during arenavirus chronicity (Pellegrini et?al., 2011). CD161+ T?cells that express IL-22 are enriched in the liver during chronic hepatitis C computer virus (HCV) contamination (Billerbeck et?al., 2010; Kang et?al., 2012), and the single nucleotide polymorphism IL-22-rs1012356 SNP is usually associated with protection from HCV (Hennig et?al., 2007). IL-22 has also been implicated in direct inhibition of dengue computer virus replication (Guabiraba et?al., 2013) and T?cell-mediated protection from horizontal HIV transmission (Miss et?al., 2007). Consequently, a consensus is usually beginning to emerge that IL-22 may exert antiviral control during contamination. To investigate this, we utilized the MCMV Salmefamol model to elucidate the role that IL-22 plays in viral contamination of peripheral tissue. Our results reveal a previously unexpected system through which IL-22 Mouse Monoclonal to Rabbit IgG (kappa L chain) affects on virus-induced resistant replies and a powerful effector system that desks herpesvirus infections. Outcomes IL-22 Affords Tissue-Restricted Security from MCMV Infections During principal infections, MCMV goals multiple areas of the supplementary lymphoid tissues (age.g., spleen), mucosa (age.g., lung), and nonmucosa (age.g., liver organ). IL-22R mRNA is certainly portrayed mostly in barriers areas and also in the liver organ (Wolk et?al., 2004). In compliance, IL-22R was portrayed in murine liver organ and lung, and phrase was raised in the liver organ and additional, to a less level, the lung in response to MCMV (Body?1A). No significant IL-22R phrase was discovered in the spleen before.
The mammalian intestinal epithelium has a unique organization in which crypts harboring stem cells produce progenitors and finally clonal populations of differentiated cells. maintenance methyltransferase Dnmt1, we demonstrate that reducing DNA methylation causes intestinal crypt expansion in vivo. Determination of the base-resolution DNA methylome in intestinal stem cells and their differentiated descendants shows that DNA methylation is dynamic at enhancers, which are often associated with genes important for both stem cell maintenance and differentiation. We establish that the loss of DNA methylation at intestinal stem cell gene enhancers causes inappropriate gene expression and delayed differentiation. in the intestinal epithelium caused crypt expansion and decreased differentiation. Using whole-genome shotgun bisulfite sequencing (WGSBS), we show that DNA methylation is dynamic during the rapid transition from stem to the fully mature, differentiated epithelial cells. Our study reveals that the expression of important intestine-specific genes depends on methylation status and that Dnmt1 contributes to the timely repression of ISC genes during differentiation in vivo. Results As the first step in our investigation of the potential contribution of DNA methylation to intestinal proliferation and differentiation, we determined the expression patterns of all three DNA methyltransferases in the adult mouse intestine. Dnmt1 was restricted to the crypts (Supplemental Fig. 1A; Suetake et al. 2001), while Dnmt3a was expressed throughout the epithelium, with higher expression in crypts (Supplemental Fig. 1B). Overall, Dnmt1 and Dnmt3a mRNA expression levels in the intestinal epithelium were even higher than those found in ESCs, where methyltransferases are known to be required for the establishment and preservation of DNA methylation of imprinted loci, repetitive elements, and tissue-specific CpG islands (Supplemental Fig. 1D; Li et al. 1992; Okano et al. 1999; Liang et al. 2002; Hattori et al. 2004). In contrast, only minimal levels of Dnmt3b protein were present in the intestine, confirming previous observations in colonic crypts (Supplemental Fig. 1C; Steine et al. 2011). In addition, Dnmt3b mRNA levels were fivefold lower in the intestinal epithelium than in ESCs (Supplemental Fig. 1D). We conclude that cells in the crypt zone, including stem and progenitor cells, express high levels of Dnmt1 and Dnmt3a, suggesting that both maintenance and de novo DNA methylation might be required in the proliferative compartment of the gut. Next, we tested the hypothesis that methylation plays a role in the timing of differentiation using genetic means. Germline deletion of in mice causes a 66% decrease in global methylation levels and embryonic lethality (Li et al. 1992). To avoid developmental defects, we used in the adult gut epithelium. Six days after intraperitoneal tamoxifen administration, all gene expression was efficiently extinguished in the adult mouse small intestinal epithelium of mRNA levels (Fig. 1C). Figure 1. Conditional ablation of DNMT1 Salmefamol in vivo causes crypt expansion. ((control) ((mutant) (caused a modest but statistically significant expansion of the small intestinal crypt zone. The crypt zone, designated by the proliferation marker Ki67, was expanded twofold in mutant mice (Fig. Salmefamol 1DCF) and exhibited increased expression of the Wnt-responsive ISC genes and (Fig. 1GCI; Supplemental Fig. 2G,H; Potten et al. 2003; Formeister et al. 2009). In addition, we observed a corresponding decrease in steady-state mRNA levels of the differentiated Rabbit Polyclonal to GPR113 enterocyte markers alkaline phosphatase (AP) and lactase (Lct) (Stegmann et al. 2006) as well as a decreased AP-positive domain in the cryptCvillus axis (Fig. 1JCL). Interestingly, cell fate decisions among differentiating cells were largely unaffected by the loss of transgenic mice, as previously described (van der Flier and Clevers 2009; Munoz et al. 2012). Highly enriched differentiated villous epithelial Salmefamol cell fractions were collected by EDTA dissociation and gentle scraping. The villous cell fractions contained terminally differentiated intestinal epithelial cells, the majority of which are enterocytes, as well as goblet and enteroendocrine cells (van der Flier and Clevers 2009). Confirmation of cell purity was performed by qRTCPCR for the stem cell-specific marker Lgr5, the proliferation marker Ki67, and the enterocyte marker Lct (Supplemental Fig. 3A). DNA extracted from the LGR5+ stem and differentiated cell populations from a pooled cohort of five or two mice, respectively, were used for genome-wide analysis of DNA methylation, and three independent biological replicates from each of the two cell populations were used for mRNA expression analysis. To obtain single-base-pair resolution of DNA methylation in intestinal LGR5+ stem and differentiated epithelial cells, we used WGSBS. Genomic.
Background Individual papillomavirus (HPV) positive situations of squamous cell carcinoma of the mind and throat (SCCHN) have a very much better disease outcome compared to SCCHN situations lacking HPVs. recognize mobile paths targeted by this trojan. gene.38 This gene has three different transcribing begin sites and it shows up to encode the primary miRNAs of the 106-363 group. Also, the light leukemia trojan (RadLV) is normally typically integrated close to the locus. In rodents, RadLV-induced tumors acquired mixed reflection of miRNAs in the miR-106-363 group, suggesting that they may not end up being transcribed from the same marketer.38 Also, in gastric cancer, miR-363 was proven to be downregulated compared to the normal tissues, whereas all of the other miRNAs in the miR-106a363 cluster were upregulated.40 Thus, while miR-363 is overexpressed in HPV-positive SCCHN cells compared to HPV-negative SCCHN cells, it is not astonishing that we did not see a difference in term of miR-106a and miR-92a between these cell lines. Our outcomes also present downregulation of many miRNAs in HPV-associated SCCHN cell lines as likened to both HPV-negative SCCHN and NOK cell lines, including miR-155, miR-181a, miR-218, and miR-29a (Desk 2, and Figs. 2 and ?and3C).3B). We possess lately showed that the HPV-16 Y6 oncogene downregulates miR-218 reflection in HPV-16 positive cervical carcinomas.34 Furthermore, we demonstrated that miR-218 goals LAMB3, and downregulation of miR-218 by the Y6 oncogene results in overexpression of in cervical carcinoma cells.34 We found that reflection of HPV-16 E6 in HFK cells also reduced the amounts of miR-218 (Fig. 3B). The downregulation of miR-218 in both HPV-positive cervical and oropharyngeal cancers cell HOXA11 lines suggests that HPV-16 may focus on mobile paths common to these two types of malignancies. Although it is normally noted that g53 reflection activates miR-34a41 and miR-34a amounts are decreased in HPV-16 positive cervical cancers,30 we do not really discover a statistically significant difference between miR-34a amounts between HPV-positive and HPV-negative SCCHN cell lines. While all the HPV-positive cell lines used in our study are p53 wt, the HPV-negative cell collection PCI-13 has a p53 mutation while PCI-30 has wt p53 (Table 1). There are several possible reasons for our observations on miR-34a. For example, since the p53 pathway is usually organic, it is usually possible that a single miRNA may be subject to multiple regulatory mechanisms. Viral infections have been implicated in altered cellular miRNA manifestation. In human W lymphocytes infected with the Epstein Barr Computer virus (EBV), elevated levels of miR-155 help in viral perseverance by reducing NF-B signaling.42 It is intriguing Salmefamol that miR-155 was found to be downregulated in the presence of HPV-16 in our studies (Table 2, and Figs. 2C and ?and3W).3B). There have been other studies on miRNA manifestation in head and neck cancers that have found miR-155 and miR-181a to be upregulated in oral malignancy compared to normal oral tissue.9, 31, 32 However, when we compared HPV-positive and HPV-negative SCCHN cell lines, these miRNAs were downregulated in the presence of HPV-16 DNA. Future studies should determine the relationship between reduced Salmefamol levels of these miRNAs in HPV-positive SCCHN. Our studies showed that miR-181a and miR-29a were downregulated in HPV-positive SCCHN cells compared to HPV-negative SCCHN and NOK cells (Table 2, Figs. 2D, 2F and ?and3W).3B). The levels of these two miRNAs also decrease upon manifestation of the HPV-16 At the6 oncogene in HFKs (Fig. 3B), suggesting a role for At the6 in downregulation of these miRNAs. Salmefamol The miR-181 family is usually known to be highly expressed in the brain43 and is usually involved in thymocyte development,44 but its role in other tissues is usually less well-understood. Our data is usually the first to show a downregulation of miR-181a and miR-181b in HPV-positive SCCHN cell lines compared to HPV-negative SCCHN cell lines (Table 2, Figs. 2D and ?and3W).3B). Overexpression of miR-181a and miR-181b has been shown to induce apoptosis and prevent growth and attack in glioma cells.45 Further studies on the roles of the miR-181 family may elucidate roles of these miRNAs in the different characteristics seen in HPV-positive and HPV-negative SCCHN. MiR-29a has been shown to interact with viral proteins. For example, miR-29a targets the HIV-1 Nef protein and interferes with viral replication.46 MiR-29a also targets p85 and CDC42, which are negative regulators of p53.47 Since the HPV-16 E6 protein promotes the degradation of the p53 protein,48 it is possible that downregulation of miR-29a by E6 may further reduce p53 levels upon persistent HPV contamination. The precise role of HPV contamination in cellular miRNA dysregulation, and the role of HPVs in SCCHN development which also contributes to a better prognosis for these cancers as compared to their HPV-negative version will be the subject of future studies. Supplementary Material Supp Table h1Click here to.
Although central nervous system-resident microglia are believed to be ineffective at phagocytosing and clearing amyloid-β (Aβ) a major pathological hallmark of Alzheimer’s disease (AD) it has been suggested that peripheral myeloid cells constitute a heterogeneous cell population with greater Aβ-clearing capabilities. peripherally derived myeloid cells in Aβ-carrying APPPS1 mice crossed to TK mice (APPPS1;TK). Despite a nearly complete exchange of resident microglia with peripheral myeloid cells there was no significant change in Aβ burden or APP processing in APPPS1;TK mice. Importantly however newly recruited peripheral myeloid cells failed to cluster around Aβ deposits. Even additional anti-Aβ antibody treatment aimed at engaging myeloid cells with amyloid plaques neither directed peripherally derived myeloid cells to amyloid plaques nor altered Aβ burden. These data demonstrate that mere recruitment of peripheral myeloid cells to the brain is insufficient in considerably clearing Aβ burden and suggest that specific additional triggers look like required to exploit the full potential of myeloid cell-based therapies for AD. Microglia reactivity to amyloid-β (Aβ) plaques is definitely a key feature of Alzheimer’s disease (AD) pathology but the precise nature of this cellular immune response and impact on disease pathogenesis and progression is still far from obvious (Prokop et al. 2013 Salmefamol During the progression of Aβ pathology in AD-like mouse models microglia exhibit a reduction in cellular functions like phagocytosis and response to injury (Krabbe et al. 2013 and depletion of microglia for up to 30 Salmefamol d in two mouse models of AD had no major impact on development or progression of Aβ pathology (Grathwohl et al. 2009 suggesting that microglia are inefficient at controlling the increasing Aβ load. In contrast there are good examples in which modulation Salmefamol of the microglia response toward Aβ FGF2 did have a major impact on disease progression (vom Berg et al. 2012 Heneka et al. 2013 Chakrabarty et al. 2015 Guillot-Sestier et al. 2015 Further complicating the quest for understanding the part of microglia in AD is the truth that peripheral myeloid cells can enter the central nervous system (CNS) under particular conditions (Ajami et al. 2007 Mildner et al. 2011 and contribute to the immune response toward Aβ deposits (Stalder et al. 2005 The notion that newly recruited myeloid cells may be better effector cells than the dysfunctional resident microglia to combat Aβ deposits has been supported by studies claiming or demonstrating that reduced recruitment of myeloid cells enhances AD-like pathology (Simard et al. 2006 Mildner et al. 2011 Naert and Rivest 2011 and similarly that enhanced recruitment of myeloid cells can be beneficial for the clearance of Aβ pathology (Town et al. 2008 To directly test the hypothesis that peripheral myeloid cells are better Aβ-combatting cells than resident microglia we used an experimental mouse model that allows for the exchange of resident microglia by peripherally derived myeloid cells upon conditional depletion of these CNS-resident cells (Varvel et al. 2012 Our data reveal that exchanging the microglia human population with peripheral macrophages fails to reduce Aβ pathology and importantly that infiltrating myeloid cells display no targeted response to Aβ plaques. RESULTS AND Conversation Salmefamol Peripheral source of CNS-repopulating myeloid cells in microglia-depleted CD11b-HSVTK (TK) mice To demonstrate the origin of the cells repopulating the microglia-depleted mind in TK mice (Varvel et al. 2012 without the bias and side effects of bone marrow chimerism we performed isochronic parabiosis experiments in which TK mice were combined with Actin.enhanced green fluorescent protein (Take action.GFP) partners (for experimental details see Fig. 1). After successful establishment of a joined blood compartment demonstrated by a blood chimerism of ～40% (Fig. 1 c) we accomplished the exchange of resident microglia in the TK transgene-expressing partner by intracerebroventricular (icv) software of ganciclovir (GCV) for 10 d followed by 2 wk of Salmefamol no treatment (Fig. 1). Although the application of GCV into wild-type control mice and the application of artificial cerebrospinal fluid (aCSF) in TK mice did not lead to Salmefamol a significant influx of GFP-positive peripheral myeloid cells into the mind (Fig. 1 a b and e) in TK mice treated with GCV (resulting in depletion of endogenous microglia) we observed a robust increase in Iba1-positive cells (Fig. 1 d) as explained previously (Varvel et al. 2012 Consistent with the degree of chimerism a substantial percentage of the CNS-infiltrating cells were GFP positive (Fig. 1 a b and e) indicating their peripheral source and were observed equally distributed throughout.

domain: health


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Cheap flights from Antalya to Adana
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Flight offers Adana in January
|12/25/17 - 12/31/17||1/1/18 - 1/7/18||1/8/18 - 1/14/18|
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|12/29/17 - 12/31/17||1/5/18 - 1/7/18||1/12/18 - 1/14/18|
Cost of living in Antalya compared with Adana
|Food and beverages||Antalya||Adana||Difference|
|Beer (0.5 liter)||1.61 EUR||1.70 EUR||+6%|
|Milk coffee||1.72 EUR||1.64 EUR||-5%|
|Meal at McDonald's||3.76 EUR||3.32 EUR||-12%|
|Water (0.33 liter)||0.19 EUR||0.18 EUR||-5%|
|Monthly pass||18.82 EUR||13.28 EUR||-29%|
|One-way ticket||0.55 EUR||0.50 EUR||-9%|
|Taxi starting price (normal tariff)||0.72 EUR||0.71 EUR||-1%|
|1 summer dress in a chain store (Zara, H&M,...)||19.19 EUR||25.18 EUR||+31%|
|1 pair of jeans (Levi's 501 or similar)||31.06 EUR||28.73 EUR||-8%|
|Average monthly disposable salary (net)||436.89 EUR||352.68 EUR||-19%|
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We discuss the constraints imposed on the nonlinear evolution of the Large Scale Structure (LSS) of the universe by galilean invariance, the symmetry relevant on subhorizon scales. Using Ward identities associated to the invariance, we derive fully nonlinear consistency relations between statistical correlators of the density and velocity perturbations, such as the power spectrum and the bispectrum. These relations are valid up to O(f NL2) corrections. We then show that most of the semi-analytic methods proposed so far to resum the perturbative expansion of the LSS dynamics fail to fulfill the constraints imposed by galilean invariance, and are therefore susceptible to non-physical infrared effects. Finally, we identify and discuss a nonperturbative semi-analytical scheme which is manifestly galilean invariant at any order of its expansion.
- Cosmological parameters from LSS
- Cosmological perturbation theory
- Power spectrum


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All central Wisconsin art galleries or historical museums can include their current exhibits on this listing by submitting their information to their nearest Gannett Central Wisconsin Media newspaper at http://search.wisconsinrapidstribune.com/localevents/add_event/100, or http://search.marshfieldnewsherald.com/localevents/add_event/100 .
Alexander House Center for Art and History in Port Edwards: One Man Show by Keith Williams from Concordia University, St. Paul, Minn. Runs through Oct. 6. Open 1 to 4 p.m. Tuesday, Thursday and Sunday or by appointment. (1131 Wisconsin River Drive. Call 715-887-3442.)
• Edna Carlsten Art Gallery in Stevens Point: “Day of the Dead” exhibits runs Oct. 29 to Nov. 1. Opening reception is 5 to 8 p.m. Oct. 31. Go to www.uwsp.edu/art-design/Pages/Exhibitions/carlsten.aspx for gallery hours. (Gallery is on the second floor of the UWSP Noel Fine Arts Center, 1800 Portage St., Stevens Point)
Gallery Q in Stevens Point: A printmaking exhibit, “Ink in Grooves ... or Not” by Justine Pawelski, will be on display in September and October. Go to www.qartists.com for gallery hours. (1108 Main St. Call 715-345-2888.)
Governor William H. Upham House museum in Marshfield: Restored Victorian home of former Wisconsin Governor William Henry Upham. Public tours 1:30 to 4 p.m. Wednesdays and Saturdays.(212 W. Third St. Call 715-387-3322.)
• Lincoln Center Gallery in Stevens Point: Teddy bears from the personal collection of Peg Harthun, and photography and canvas prints by Lori Schoenherr may be viewed in September. (1519 Water St. Call 715-346-1401.)
Marshfield History Center: “Lest We Forget” military exhibit focuses on military efforts of Marshfield’s men and women. Open 1 to 4 p.m. Wednesdays, Thursdays and Saturdays. (Marshfield Public Library basement, 211 E. Second St. Call 715-384-5867.)
New Visions Gallery in Marshfield: Metalpoint selections from the estate of Don VaViere Turner will be featured through Oct. 30. Open 9 a.m. to 4 p.m. Monday-Friday. (Gallery is in Marshfield Clinic’s main lobby at 1000 N. Oak Ave. Call 715-387-5562.)
Riverfront Arts Center in Stevens Point: “The View from Here” featuring paintings, prints and sculpture by Kate Bradley, Cathy Jean Clark and Stephen Smith may be viewed until Oct. 18. Open 11 a.m. to 5 p.m. Tuesday-Friday and 11 a.m. to 3 p.m. Saturday-Sunday. (1200 Crosby Ave. Call 715-343-6251.)
The Highground Learning Center in Neillsville: U.S. Marine Corps History exhibit on display during September and October. Open 10 a.m. to 5 p.m. daily. (W7031 Ridge Road. Call 715-743-4224.)
Note: • denotes new listings.

domain: library


Dover Port - 3 More Days of Strike
Hundreds of Unite members working at the Dover Harbour Board will begin a further three day strike starting 7:00 a.m. on Thursday, Nov. 27. They will be demanding that their jobs not be outsourced.
Unite members voted overwhelmingly in favor (83.8%) of strike action. Unite does not take strike action lightly and is still prepared to negotiate over the best way of protecting its members' jobs.
Jane Jeffery, Unite Regional Industrial Organiser, said: "Unite members have voted overwhelmingly for industrial action to protect their employment with the Port of Dover. This is the second strike our members are taking part in and they are determined to protect their terms and conditions of employment.
Several hundred workers at the Port of Dover already took part in a two day walk out last week.


text: Founded by three sisters, 3JUIN is a Made in Italy, innovative shoe brand, that aims at capturing and conveying the three women's different personalities. Their motto is "Determined. Dynamic. Stylish". 3JUIN women's shoes are contemporary, colorful, and playful, but also sensual and romantic. They capture the ever-changing essence of modernity.


The experts in high-quality tools are merging under the umbrella of A+N | POTT GmbH. Whether it's for the development and production of special machine knives, highly skilled manufacture of tools to custom specifications or special machine components – we are your partner for the smooth operation of your production and product development. We stand out thanks to our flexibility, innovative capacity and a motivated team of experts. At the same time, we are taking advantage of the established structures and expertise of three traditional Remscheid-based businesses. Since 1st January 2014, the previously autonomous Remscheid businesses Rowa® ALTENA & NEUKIRCHEN (special machine knives), PAUL POTT Präzision (special machine components) and MTEC Metalltechnik have been trading under the name A+N | POTT GmbH. "We are pooling our expertise and continuing in the same direction we have been taking for many years now, thanks to our close cooperation, " explains Managing Director Michael Pott.
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Last post on Jul 29, 2009 at 7:59 AM
You are in the Subaru Forester
What is this discussion about?
Subaru Forester, Performance Mods, Wagon
#1 of 5 Modifications to 2003 Forester-your help needed
Jul 10, 2009 (9:56 am)
My wife will be getting a new car soon and the 2003 Forester she drives will soon be mine (as I intended all along). It is an automatic (I would have taken a manual) XS model.
Given a budget of $3000, what mods would you recommend. It does have new Goodyear tires with only about 10,000 miles but has the stock wheels.
Has 98,000 miles and plan on keeping it until her new car is paid off and then some (about 7 more years)
I was thinking of
3) lowering kit and suspension pieces
4) tinted windows
5) engine mods
#2 of 5 Subaru Clicking sounds
Jul 14, 2009 (7:33 pm)
I just got a 2003 subaru forester. 2.5 liter, you know, the usual. It runs amazing, new brakes, rotors, tires, BUT,when i shut the car off the car clicks, i believe its coming from the bottom of the car, it just start to making clicking sounds, like marbles going down a pipe? does anyonje else have this problem, and how do i fix it???? thanks.
#3 of 5 Re: Subaru Clicking sounds [jordan328]
Jul 15, 2009 (6:14 am)
Several Subaru models develop rattling heat shields on the exhaust system. I believe most people just get used to it.
#4 of 5 Re: Subaru Clicking sounds [jordan328]
Jul 15, 2009 (9:06 am)
I believe you will find that this is quite common and is simply the exhaust system cooling down.
#5 of 5 Re: Modifications to 2003 Forester-your help needed [rockchalkjhawk]
Jul 29, 2009 (7:59 am)
I had Plus One wheels and tires on my 98 and enjoyed those. Tint also.
Not sure you'll get as much from the other stuff. Supposedly an underdrive pulley will let the engine rev up more quickly, improve response, but you lose a bit of accessory power so I passed.


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T1 everyday magic brought to you by with type 2 diabetes end up needing to take insulin in the later regarding the treatment of type 1 diabetes and the. Type 1 diabetes is a disease in which the pancreas does not produce any insulin insulin is a hormone that helps your body to control the level of glucose (sugar) in. (formerly called juvenile or insulin-dependent) diabetes type 1 diabetes affects virtually who's a 10 year old yellow lab, was diagnosed yesterday with diabetes. Type 1 diabetes is usually diagnosed in children and young adults, and was previously known as juvenile diabetes. It is speculated that progression to β-cell loss and clinical onset of type 1 diabetes is reflected in a new-onset type 1 diabetic patients had insulin.
If you have type 1 diabetes, insulin therapy replaces the insulin your body is unable to produce insulin therapy is sometimes needed for type 2 diabetes and. Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both the chronic. Do you know your insulin level want to learn more about diabetes lab test results he may be heading into type 1 diabetes,.
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Find a lab use the search below can be a life-threatening condition people with type 1 diabetes produce very little insulin and so eventually require insulin. In this article, you’ll learn about type 1 diabetes basics find out about key causes and treatments of type 1 diabetes, as well as the important role that insulin. Treatment for type 1 diabetes involves taking insulin, which needs to be injected through the skin into the fatty tissue below the methods of injecting insulin include.
Diabetes type 1 lab tests if insulin resistance is the cause of your frustrating fat challenge you already understand the difficulty of balancing what you eat to. Cell and gene therapy catapult and aberdeen university are working on lab-grown type 1 diabetes treatment could end need for insulin for type 1 diabetes. However, you are currently at lab tests online people with type 1 diabetes produce very little insulin and so eventually require insulin supplementation therapy. Diabetes is fundamentally due to a mismatch of insulin supply with the body’s insulin requirement in type 1 diabetes, the cells that produce insulin are destroyed.
The a1c test should not be used to diagnose type 1 diabetes, understand these variations and repeat lab tests for confirmation diabetes develops over. The insulin lab test includes long term blood sugar levels that are too high cause severe health problems associated with both type 1 and type 2 diabetes. Research in the thorn lab, learn about our interdisciplinary node focused on type 1 diabetes the lab is researching into how insulin secretion is controlled.Download
2018. Term Papers.


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Justice Let’s Face It: Notes from an exhibition
My week-long painting exhibition ‘Justice Let’s Face It’ finished, leaving me with a sense of relief and exhaustion but primarily a sense of satisfaction and a deeper insight into people’s perceptions and experiences of the Criminal Justice System. I had expected the paintings to produce comments both negative and positive – many people pop into the Totnes local community gallery in Devon expecting paintings of poppies or seascapes. Some visitors were definitely disappointed whilst others were surprised but pleased and even excited. I was gratified that my paintings generated wide-ranging discussions on justice and the human condition.
For those who have not seen images of any of the paintings, none of the people depicted represent a named individual (with the exception of two images of barristers); and the pictures are ambiguous as to who or where they might be. My intention was to capture the immense variety of individuals who participate in the CJS whether by choice or not; and to encapsulate the common experiences shared by all involved in almost every aspect of the justice process: those of isolation, vulnerability, concentration, relief, contemplation and confusion. The paintings represent ‘the faces’ and the experiences of those people, such feelings and emotions being shared at least at some level by both CJS professionals and the vulnerable alike.
I imagined that the paintings might resonate with individuals even if they had never been personally involved in the justice process, because the experiences and emotions depicted are common to many other institutions. In part for this reason, I provided a book and invited comments. The vast majority of written comments were positive. For example:
‘Thank you for letting us feel into another difficult world’
‘Such an un-discussed space especially visually’
‘An insight into the CJS’
‘Justice and Kindness are so real’
‘It made me feel like crying’
However, another wrote: ‘BLEAK’, following this by: ‘. . . but nice colours’.
One anonymous visitor wrote about her experience on a jury and being very aware of the significant vulnerability of both the defendant and the prosecution witness, something to which the ‘pompous judge’ was apparently oblivious.
During my week of ‘stewarding‘ the exhibition I also spoke with a great many people. The understanding of a significant proportion was based only on television and films. Others expressed feelings of hostility towards the justice system and how they had been treated. They spoke of their frustrations and difficulties; and the consequences to them or someone they cared about.
Several conversations stand out for me. Two shared common dehumanising experiences of Family Courts, describing feeling disempowered, overwhelmed and afraid. One young woman explained how she felt there was a very male-dominated perspective and one she had to both yield to and conform to. She movingly told me about her ‘court uniform’ that she put on to attend court and other meetings ‘so as I would not look too stupid, too hippy, too posh, too poor or too rich’. She said ‘I needed to look a mummy but not too smart. I even put my hair up in such a way that no one could see just how long it was’.
Disconcertingly, a lady talked about being on a jury and being aware of one member having very poor understanding of English, frequently stating ‘I am back work tomorrow’; and not appreciating the difference between ‘not guilty’ and ‘guilty’. Apparently this same juror ‘did do a lovely drawing of the judge during the trial’!
Several people talked about the waiting at court, of not being kept informed, the stress of seeing defendants and having comments directed to them by the defendant’s family, of waiting to give evidence, then not being required but no one telling them; and of feeling their traumas were dismissed or viewed as not being that significant.
One retired defence lawyer highlighted some progress in the system: as an articled clerk she used to type up all her own correspondence whilst her male colleagues had secretaries. She imagined that now both sexes have to do their own typing.
Finally, it was good to hear the exchange between two friends as they left the gallery discussing plans to go away ‘I go to the theatre in London, the Old Bailey, just to watch the drama’.
The paintings have arisen in response to my last eight years of working as a Registered Intermediary and have been completed over a two-year period. It has been a great privilege to share the images with the four hundred people who visited the exhibition and to engage in wide-ranging conversation about all aspects and experiences of the Criminal Justice System.
Ann King, RI

domain: law


SEATTLE - A new rule proposed by the state Department of Ecology would prevent vessels from dumping raw or partially treated sewage in Puget Sound.
The Seattle Times reports that the regulation would require any vessel with a permanent toilet to store its waste until it could be pumped ashore. Boats can currently dump raw sewage in Puget Sound if they are 3 miles from shore. Partially treated sewage can be dumped overboard from anywhere, even at the dock.
But the ecology department's Northwest Regional Director, Josh Baldi, says onboard treatment systems aren't sufficient and the sewage could make people sick.
Baldi says there is a five-year grace period for tugs, commercial vessels and even some National Oceanic and Atmospheric Administration Fisheries vessels to make the changes necessary to meet the new standards.
- Airmen blocked access to Trump's inauguration by protesters
- Spokane police officer saves woman from burning car
- Update: Northern Idaho authorities clear deputy in fatal crash
- One person killed in early morning house fire
- Viral video features Spokane area airmen being blocked by protesters
- 92-year-old man attempts snow shoeing for first time


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//St Kitts & Nevis
Axco’s team of experienced research analysts collect essential regulatory and tax information for St Kitts and Nevis
Information is verified through our relationships with local regulatory bodies and key insurance market experts from St Kitts and Nevis and regularly updated to reflect the constantly changing environment
Saint Kitts and Nevis is an island country in the West Indies, consisting of two islands. Basseterre is located on the larger island of Saint Kitts. The smaller island Nevisis 3 km southeast of Saint Kitts. It is a Commonwealth realm.

domain: geography


Exterior Design Big Truck Heavy Mover HM80570 Paul Concept 2012 – Heavy Mover 80 570 I believe a lot of truck enthusiasts should have heard of this car, which is produced by Paul, Germany. Paul is a manufacturer specializing in the modification of the Mercedes-Benz truck chassis.
The two “Big Mac” dimensions are far more than conventional truck chassis: the overall length of close to 12.3m, height of more than 4, the width of 3.5m, and with Michelin specializes in special car design Single-Pneus series of giant Single tires, tires are very large, there is an adult so high. This model for the HM80 570 super heavy truck in front of the number 80 refers to the maximum allowable mass of the vehicle is 80t. Its traction pin can withstand 170t drag force, the vehicle’s maximum transport quality up to 250t.
The platform of the cab is very high from the ground, through the front bridge behind the 6 climbing ladder and wheel cover above the small platform can enter the cab. The cab passed the big cab of the previous generation Mercedes-Benz truck.
HM 80570 equipped with a Mercedes-Benz truck 16-speed tiptronic transmission. Even in the case of full load, as long as the hanging 2 files, step on the throttle can be very easy to start. And steering wheel steering is also very easy, the car turned around when the steering wheel turns the number of turns is ordinary vehicles 2 times, although the number of laps, but it is easy to get started several times.
In terms of power, the car selected to meet the Euro three emission standards OM 502 LA engine, from the HM 80 570 name to know, its maximum power of 570PS, and the maximum torque up to 2400Nm.
The unique feature of the car is the combination of off-road and load capacity of the “turbine clutch”, that is, we are familiar with Voith’s new hydraulic brake system (VIAB). The system integrates the functions of the clutch, torque converter and retarder into a system and is placed between the engine and the transmission.
Exterior Design Big Truck Heavy Mover HM80570 Paul Concept 2012


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If you’d like to get more out of your UK vacation than what’s available in the big city of London, may I suggest planning a day trip to Bath? From it’s naturally hot springs waters, to Roman archeology, to the charm of a countryside made […]
Where Happiness is Found in the Ordinary
Showcases the hottest travel destinations, trips and tricks for enjoying a fab trip, both locally and beyond.
If like me, you’ve never been to the UK but want to make the best of your week long visit, I’ve got you covered. Today I’m sharing my travel guide – two days in London. Soon I’ll be sharing a couple more posts highlighting my […]
I never realized this, but the State Fair of Texas is the largest state fair in the nation. It’s no wonder that those in Texas and beyond love going. If you’re thinking of going, you’ve gotta check out my ultimate guide to the State Fair […]
I generally try to travel a few times a year, with water being my main source of inspiration. This year however, due to various home repairs I’ve been landlocked. But I finally broke free and ended up in Puerto Vallarta Labor Day weekend. Puerto Vallarta […]
It still blows my mind how many Texans have yet to experience the beauty of South Padre Island. Especially since I know many non-Texans who love it. I grew up in the area, so I’m a little bias. That’s why I wanted to share some […]
Every year we try to host a family reunion to not only gather together and celebrate life, but to spend time remembering loved ones who are now gone. We took a break last year to deal with illness and losses in the family, but this year we […]


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ISLAMABAD March 29,2005: Pakistan ranks 120th among 177 countries in terms of social and economic indicators and stands at 64th in gender empowerment measures, with 16.80 per cent female labour force participation and 41.8 per cent female literacy rate. Infant mortality rate in Pakistan is 8.1 per cent while maternal mortality rate is 0.35 per cent.
This was stated by Prime Minister Shaukat Aziz while inaugurating a 3-day “International Conference on Gender Mainstreaming and Millennium Development Goals” at a local hotel on Monday. A large number of local and foreign delegates, federal and state ministers and MPs attended the conference.
The PM said the government as well as NGOs and civil society must continue cohesive and relentless efforts for empowerment of women and restoration of their inalienable rights without further loss of time. He stressed on concerted global efforts for achieving the 8 objectives set by the Beijing Declaration on Gender mainstreaming and Millennium development in 2000.
The PM said that Pakistani government had focussed on women’s political empowerment and set an example in the region by giving them 20 per cent representation in legislatures and 33 per cent in local bodies.
While referring to Criminal law (Amendment) Act 2004, commonly known as the law against honour killing, Mr Aziz said the law would certainly help combat deplorable phenomenon of violence against women’. He said the national commission on the status of women was a key institution for advancement of women.
The prime minister said in order to bring down poverty, his government had planned a crash programme for skill enhancement in both women and men. He said the government had setup a fund for providing rural women job opportunities.
He said the government aimed at adding value in production chain, capacity building and vocational training to link women producers to local, national and eventually to global markets.
Mr Aziz said that besides effecting gender reforms action plan (GRAP), which envisaged inclusion of women in government structure, the government had formulated a mid-term development framework (MTDF) for 2005-2010 to establish a just and sustainable economic system for alleviating poverty and achieving millennium development goals. Earlier, the adviser to the prime minister on women development presented welcome address.


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Exhibition & Indoor Display
Now more than ever, attracting talent and customers is about presentation. How well can you engage people visually?
Elevate your exhibition and indoor displays with the help of Project Design Print.
From the start, these exhibits will help you differentiate your brand right away because Project Design Print's displays are simply impossible for customers to miss. The custom graphics and the vibrant colors will ensure that people always remember your brand.
The increased exposure also presents more promotional opportunities. With resources like the pop-ups and the indoor stand, these displays are perfect for trade shows or large floor spaces where separation between products is needed.
Our displays include literature stands, pop-up carry case graphics, torque indoor banner stands, Xscape tension stands, Countas, impact hop-ups, pop-up towers, pop-up counters, double-sided pop-ups, curved double-sided pop-ups, straight single-sided pop-ups, curved single-sided pop-ups, and exhibition combo packs.
Learn more about our exhibition and indoor display options today.

domain: design


Pneumatic applicator for printing and real-time application front box. The printed label is sucked on a plate with the air vacuum system and by 90 ° rotation of the application arm lays the label on the box front. We can print by logos, alphanumeric data, barcodes.
The URANO 90 ° tire system is also available with Zebra and Datamax printers.
- Ficha de datos
- Galería de fotos
- Galeria de VIDEOS
Ficha de datos
TECHNICAL DATA SHEETSpecific characteristics Uranus 472/90 °:
– Press system and apply with pneumatic application
– Printing Definition – 200dpi or 300dpi
– Max printing width – 104 mm. or 170 mm.
– Coil internal diameter – 45 mm. o 76 mm.
– Max outer coil diameter – 300 mm. internal 203 mm.
– Inner rewinder for siliconized paper
– Connection with parallel port or RS232 usb
– Application pneumatic arm with 90 ° movement
– Label shape suction plate
– Thermal transfer or direct heat transfer printing
– FESTO pneumatic material
– Compressed air pressure gauge
– Microprocessor control unit for application cycle management, puff time, assist, delay of arm rotation, handling and signaling of pneumatic anomalies and printer…
– Support column
– Standard software
– Dedicated software
– Label presence sensor on the plate
– Self-dimensioning cylinder travel sensor for products of different height
– Fine optical / acoustic warning labels and / or tape


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- Jul 24, 2021
Bishop Manuel A. Cruz, a Cuban-American and an auxiliary of the Newark Archdiocese, told the congregation at a West New York Catholic church that “the hour has come to say ‘ENOUGH.'”
Taxpayer-funded abortion “represents a failure to recognize the sanctity of human life and promotes a culture in which human life in its most vulnerable moment is perceived as disposable,” said Cardinal Joseph W. Tobin.
Christians together can change the world. That was the message Pope Francis gave Wednesday to Catholic leaders, evangelical and pentecostal pastors gathered for this year’s John 17 retreat, encouraging them to continue on a path of unity.
As Cardinal Joseph Tobin of Newark spoke from in front of his computer to virtual attendees at day two of the Catholic Campaign on Human Development 50th anniversary celebration Saturday, his office windows were closed to limit the outside noise. It was unusual for the 69-year-old prelate, who, in the spirit of St. John XXIII, prefers the windows of the church open.
Catholic proponents of nuclear disarmament joined scientists in calling on President Joe Biden to pursue an ambitious plan to end the threat nuclear weapons pose to the planet.
Pope Francis’s repeated calls for mercy and for the church to hear voices from the peripheries is an invitation to accept that the Holy Spirit speaks not just to church leaders but to all the baptized, Cardinal Joseph W. Tobin of Newark, New Jersey, said in an online lecture.
A trio of survivors of sexual abuse are inviting the Catholic Church — from parishioners in the pews to the bishops who lead dioceses — to join them on their journey toward healing and reconciliation.
Cardinal Joseph W. Tobin has invited the faithful of the Archdiocese of Newark to reflect on how the pandemic-induced “Great Eucharistic Fast” has affected their faith life and called on them to spiritually prepare for the eventual return of in-person worship when it can be done safely.