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Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma.
Oral squamous cell carcinoma (OSCC) is the third most common cancer in developing countries and ranks sixth among systemic cancers worldwide [1, 2]. Although there have been some improvements in the diagnosis and clinical treatment of OSCC, the 5-year overall survival rate of OSCC patients has not improved and remains <50% over the last three decades [3, 4]. In addition, many patients have a poor response to therapy and high recurrence rates . Therefore, it is important to determine effective molecular diagnostic markers and therapeutic targets of OSCC.
Circular RNAs (circRNAs) are a type of covalently closed loop structure of endogenous RNAs, which are characterized by linking the 3; and 5 ends generated by backsplicing. Unlike linear RNAs, circRNAs require high conservation, have high stability and tissue specificity, and are not easily degraded by enonuclease [6, 7]. In the 1970s, circRNAs were first discovered in Sendai viruses and then were clearly observed in eukaryotes [8, 9]. CircRNAs were initially deemed to the products of aberrant RNA splicing, without attracting attention . With the development of RNA high-throughput sequencing technology and bioinformatics, thousands of circRNAs have been discovered in the human genome . Numerous researches have shown that circRNAs can be used as new biomarkers for clinical diagnosis and treatment of cancer [12-14]. However, there is little known about the role of circRNA in OSCC.
Searching OSCC associated circRNAs from circBase . We first confirmed that hsa_circ_001242, which is located at chr10: 17157441-17168917 (Figure 1), was significantly downregulated in OSCC cell lines and OSCC tissues. Hsa_circ_001242, with a spliced sequence length of 713bp, associated gene symbol is TRDMT1 (tRNA aspartic acid methyltransferase 1) and composed of six exons from exon 3 to exon 8. Its expression levels in tissues at various stages of OSCC were then explored, and the potential relationship between hsa_circ_001242 expression levels and patients' clinicopathological factors were investigated. A receiver operating characteristic (ROC) curve was constructed for evaluating the diagnostic value of hsa_circ_001242. Our data indicate that hsa_circ_001242 may be a potential biomarker for the diagnosis of OSCC.
2. Materials and Methods
2.1. Patients and Specimens. Forty oral cancer tissue samples and paired adjacent normal tissues were collected from the Department of Oral and Maxillofacial Surgery, Shenzhen Hospital, Peking University (Shenzhen, China), from December 2016 to May 2017. All samples were verified by histopathology. No patient previously underwent OSCC surgery, chemotherapy, or radiotherapy. Tissue samples were stored at -80[degrees]C before use. This study was approved by Ethics Committee of Peking University Health Science Center (IRB00001053-08043).
2.2. RNA Extraction. Total RNA was extracted from OSCC tissues and paired adjacent normal tissues using the TRIzol reagent (Invitrogen, Carlsbad, CA, USA) according to the manufacturer's protocol. Total RNA from each specimen was quantified, and quality assurance was conducted using a NanoDrop ND2000 spectrophotometer (NanoDrop, Wilmington, DE, USA). Reaction mixture (20 [micro]l) containing 1 [micro]g total RNA was reverse transcribed to cDNA using PrimeScript RT-polymerase (Takara, Dalian, China).
The RNA sample was dissolved in RNase-free water. The yield and purity were measured using a NanoDrop 2000 instrument (Thermo Fisher Scientific, Waltham, MA, USA). The integrity of the RNA was determined using 1% formaldehyde denaturing gel electrophoresis. A PrimeScript RT Reagent Kit (Takara Bio, Nojihigashi, Kusatsu, Japan) was used for the production of complementary DNA (cDNA) by reverse transcription, according to the manufacturer's instructions. qRT-PCR was performed using SYBR-Green Premix Ex Taq (Takara Bio, Nojihigashi, Kusatsu, Japan) and was monitored using the ABI PRISM 7500 Sequence Detection System (Applied Biosystems, Life Technologies, Waltham, MA, USA). The relative expression levels of circRNAs were determined by qRT-PCR. The sequences of the primers used in the qRT-PCR assay are shown in Supplementary Table 1.
The sequences of the hsa_circ_001242 primers were as follow: 5'-GCCCACTTGTAGAAGGTCCG-3' (forward primer) and reverse 5'-CTGGCAGGGAGGGCTCATTA-3' (reverse primer). The primer sequences for [beta]-actin were 5'-AAACTGGAACGTTGAGAGTG-3' (forward primer) and 5'-AGTGGTCTGGCTTTTAGGT-3' (reverse primer). The reaction conditions were as follows: 95[degrees]C at 5 min for a preincubation and 40 cycles of 95[degrees]C for 5 s, annealing temperature of 60[degrees]C for primer pairs for 30 s, and 72[degrees]C for 20 s. RNA levels were normalized using [beta]-actin as the internal control.
2.3. Cell Culture. The human OSCC cell lines, SCC9, SCC15, SCC25, and CAL27, were obtained from the College of Stomatology, Wuhan University (Wuhan, China). Human oral keratinocytes (HOK) cells were obtained from the cell bank of the Chinese Academy of Sciences (Shanghai, China). SCC9 cells were cultured in DMED/F12 medium supplemented with 1% penicillin/streptomycin. SCC15, SCC25, CAL27, and HOK cells were cultured in Dulbecco's Modified Eagle Medium (DMED, GIBCO, China) supplemented with 1% penicillin/streptomycin (Life Technologies Inc., USA). All cells were cultured at 37[degrees]C under 5% C[O.sub.2].
2.4. Statistical Analysis. GraphPad Prism 5.0 Software (GraphPad Software, La Jolla, CA, USA) was used to analyze the obtained data. Results of hsa_circ_001242 expression for OSCC tissues and paired adjacent normal tissues or between OSCC cell lines and HOK cell lines were compared using a paired t-test. A nonpaired t-test was used to analyze the relationship between hsa_circ_001242 expression level and clinicopathological factors in OSCC patients. The ROC curve was constructed to evaluate the diagnostic values. * P <0.05, ** P <0.01, and *** P <0.001 were considered statistically significant.
3.1. Expression of hsa_circ_001242 in OSCC Tissues. In this study, we first observed that the expression levels of hsa_circ_001242 were evidently downregulated in 40 OSCC tissue samples compared to that in paired adjacent normal tissues by qRT-PCR (n = 40, P < 0.001) (Figure 2).
3.2. Hsa_circ_001242 Expression Levels in OSCC Cell Lines. Furthermore, we explored the expression levels of hsa_circ_001242 in the HOK cell lines and four human OSCC cell lines, SCC-9, SCC-15, SCC-25, and CAL27. Expression levels in the OSCC cell lines were significantly lower than those in the HOK cell lines (Figure 3).
3.3. Relationship between hsa_circ_001242 Levels and Clinicopathological Factors. Clinicopathological analysis revealed that hsa_circ_001242 expression level was significantly associated with clinicopathological factors of OSCC patients. As presented in Table 1, hsa_circ_001242 expression levels were negatively related to tumor size (P = 0.0125) and T stage (P = 0.0434) but were not associated with other clinicopathological features, such as age, gender, tumor differentiation, TNM stage, or lymphatic metastasis (P > 0.05).
3.4. The Diagnostic Value of hsa_circ_001242 in OSCC. To estimate the diagnostic value of hsa_circ_001242 in OSCC, an ROC curve was constructed for differentiating OSCC tissues from paired adjacent normal tissues. The area under the ROC curve (AUC) was 0.784 (95% confidence interval (CI) = 0.717-0.867; P < 0.001; Figure 4(a)). The cutoff value was 14.4 (Figure 4(b)), and the corresponding sensitivity and specificity of hsa_circ_001242 were 72.5% and 77.5%, respectively. When the area under the curve is larger, the diagnostic value of the variable is higher. Values below the cutoff value are negative, while those exceeding the cutoff value are positive. Therefore, hsa_circ_001242 may act as a potential biomarker for the diagnosis of OSCC.
CircRNAs are a class of noncoding RNAs (ncRNAs) that have been neglected as transcriptional noise in eukaryotes for the past 30 years [10, 16, 17]. Recent studies have found that some circRNAs serve as an important regulatory role and do not splice noise as previously thought . Compelling evidence has manifested that circRNA can regulate gene expression through multiple mechanisms. CircRNAs act as a sponge of miRNA molecules and competitively bind miRNAs to regulate gene expression [19, 20]. Exon-intron circRNAs (EIciRNAs) can regulate transcription by RNA-RNA interactions in the nucleus [21, 22]. Some reports showed that circRNAs have the function of being translated into proteins [23, 24]. These studies indicate that the circular RNA plays an important role in transcriptional and posttranscriptional levels and can serve as an ideal marker for disease diagnosis. Previous studies have suggested that circRNAs may play an important role in the development of cancer and act as potential biomarkers for cancer [25, 26]. For example, Li Wan et al.  have revealed that circ-ITCH is overexpressed in lung cancer tissues and inhibits the Wnt/[beta]-catenin signaling pathway by acting as a sponge for miR-7 and miR-214. Zhu et al.  have reported that circ-BANP expression in colorectal cancerous tissues is significantly upregulated than those in adjacent normal tissues. Huang et al.  have observed that hsa_circ_0000745 is downregulated in gastric cancer tissues as well as in the plasma samples from patients with gastric cancer. Their study revealed that the circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. Yao et al.  have confirmed that circZKSCAN1 is downregulated in hepatocellular carcinoma and may act as a diagnostic biomarker. Thus, we believe that circRNAs may serve as novel molecular markers for cancer.
In this study, we first observed that hsa_circ_001242 was downregulated in both OSCC tissues and OSCC cell lines. Furthermore, the study on the clinical features and the expression of hsa_circ_001242 indicated that hsa_circ_001242 expression level was negatively relevant to tumor size and T stage (Table 2). These data suggest that circRNAs may play a role in carcinogenesis and progress of OSCC. The ROC curve was constructed for differentiating OSCC tissues from the controls. Our results demonstrated that AUC was 0.784. The sensitivity and specificity of hsa_circ_001242 were 0.725 and 0.775, respectively. Furthermore, we observed that the cutoff value of hsa_circ_001242 was 14.4. To further understand the biological role of circRNAs in OSCC, both in vitro and in vivo assays should be performed in the future after successfully engineering of circRNAs.
In conclusion, our study manifested that hsa_circ_001242 was significantly downregulated in OSCC tissues and OSCC cell lines. In addition, the expression of hsa_circ_001242 expression is negatively correlated with tumor size and T stage. Thus, hsa_circ_001242 may serve as a potential diagnostic biomarker for OSCC.
The data used to support the findings of this study are available from the corresponding author upon request.
Conflicts of Interest
The authors declare that there is no conflict of interest regarding the publication of this article.
Shuai Sun and Bowen Li contributed equally to this work.
This study was supported by the National Natural Science Foundation of China (Grant no. 81572654), the Basic Research Program of Shenzhen Innovation Council of China (Grant nos. JCYJ20150403091443303, JCYJ201504030914 43286, JCYJ201604287 3933559, and SZBC2017023), and Sanming Project of Medicine in Shenzhen (SZSM 20151 2036, Oral and Maxillofacial Surgery Team, Professor Yu Guangyan, Stomatology Hospital Peking University).
Supplementary Information Table 1. Detailed information on clinical and oral squamous cell carcinoma characteristics of patients and the information of metastasis. (Supplementary Materials)
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Shuai Sun, (1,2) Bowen Li, (1,2) Yufan Wang, (2) Xiang Li, (2) Panpan Wang, (2) Feng Wang, (2) Wei Zhang (iD), (3) and Hongyu Yang (iD) (1,2)
(1) Peking University Shenzhen Hospital Clinical College, Anhui Medical University, Hefei, Anhui, China
(2) Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China
(3) Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China
Correspondence should be addressed to Wei Zhang; firstname.lastname@example.org and Hongyu Yang; email@example.com
Received 21 January 2018; Accepted 9 May 2018; Published 4 July 2018
Academic Editor: Nelson Yee
Caption: Figure 1: Hsa_circ_001242 is encoded from chromosomal region 10p13. Six exons of them form hsa_circ_001242 from exon 3 to exon 8.
Caption: Figure 2: Hsa_circ_001242 expression levels in 40 pairs of OSCC tissues compared to that in paired adjacent normal tissues. Higher [DELTA]Ct value indicates lower expression. Data are expressed as mean [+ or -] SD; *** P <0.001.
Caption: Figure 3: Hsa_circ_001242 expression in different OSCC cell lines. Hsa_circ_001242 expression levels in four OSCC cell lines (SCC-9, SCC-15, SCC-25, and CAL-27), and normal human oral keratinocyte cell lines were assessed by qRT-PCR. Data are presented as mean [+ or -] SD; * P < 0.05, ** P < 0.01, and *** P < 0.001.
Caption: Figure 4: The diagnostic value of hsa_circ_001242 in OSCC. (a) The area under the ROC curve (AUC) was 0.784 (95% CI = 0.683-0.885, P <0.001), (b) and the cutoff of hsa_circ_001242 was 14.4. The sensitivity and specificity were 0.725 and 0.775, respectively. Data are presented as mean [+ or -] SD; *** P < 0.001.
Table 1: Primer sequences. Primer set Forward primer Reverse primer hsa_circ_001242 GCCCACTTGTA CTGGCAGGGAG GAAGGTCCG GGCTCATTA [beta]-Actin AAACTGGAACG AGTGGTCTGGC TTGAGAGTG TTTTAGGT Table 2: Correlation between clinicopathological factors and hsa_circ_001242 expression levels ([DELTA]Ct) in oral squamous cell carcinoma patients. Characteristics Number of Mean [+ or -] SD patients Age (year) [greater than or equal to] 60 14 16.88 [+ or -] 0.644 <60 26 15.52 [+ or -] 0.572 Gender Male 28 16.05 [+ or -] 0.537 Female 12 15.89 [+ or -] 0.813 Tumor size(cm) [greater than or equal to] 5 6 13.43 [+ or -] 0.543 <5 34 16.45 [+ or -] 0.408 Differentiation Well and moderate 34 16.23 [+ or -] 0.424 Poor 6 14.70 [+ or -] 0.747 T stage T1-2 29 16.58 [+ or -] 0.45 T3-4 11 14.47 [+ or -] 0.99 TNM I and II 19 16.76 [+ or -] 0.61 III and IV 21 15.31 [+ or -] 0.61 Lymphatic metastasis N0 24 16.50 [+ or -] 0.516 N1-3 16 15.25 [+ or -] 0.773 Characteristics P value Age (year) [greater than or equal to] 60 0.145 <60 Gender Male 0.871 Female Tumor size(cm) [greater than or equal to] 5 0.0125 * <5 Differentiation Well and moderate 0.221 Poor T stage T1-2 0.0317 * T3-4 TNM I and II 0.103 III and IV Lymphatic metastasis N0 0.170 N1-3 * indicated statistical significance.
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|Author:||Sun, Shuai; Li, Bowen; Wang, Yufan; Li, Xiang; Wang, Panpan; Wang, Feng; Zhang, Wei; Yang, Hongyu|
|Date:||Jan 1, 2018|
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What is Brugada syndrome?
Brugada syndrome is a genetic disorder that can cause a dangerous irregular heartbeat. When this happens, the lower chambers of your heart (ventricles) beat fast and irregularly. This prevents blood from circulating correctly in your body. This can be dangerous and may lead to fainting or even death, especially during sleep or rest. The disease has been called sudden, unexplained nocturnal death syndrome because people with it can often die in their sleep.
Brugada syndrome is rare. It affects about 5 of every 10,000 people worldwide. Symptoms often start during adulthood. But the disorder can develop at any age. This includes infancy. The average age when the syndrome is first diagnosed is around 40 years old.
What causes Brugada syndrome?
The genetic form of Brugada syndrome is most often caused by a defect in certain genes that handle sodium. But other genes can be involved, too. It can be inherited from just one parent. But some people develop a new defect of the gene rather than inheriting it from a parent. These genetic defects cause malfunctioning sodium channels in the heart muscle cells. This may lead to abnormal heart rhythms.
It's possible to have Brugada syndrome that stays inactive (dormant) and doesn't cause any problems. But some medicines, can unmask the syndrome. These include antidepressants and antipsychotics, illegal drugs, conditions that cause fever, and electrolyte problems. Some people may seem to have Brugada syndrome based on certain characteristics seen on an electrocardiogram (ECG). But they don't actually have the disease itself. This is called a Brugada ECG pattern. It may not pose a risk if the condition is short-term (temporary). And if it doesn't cause symptoms or dangerous heart rhythms.
Who is at risk for Brugada syndrome?
People who are at greatest risk for the disorder are those of Asian descent, particularly Japanese and Southeast Asian heritage. It occurs 8 to 10 times more often in men than in women. Researchers think the male hormone testosterone may contribute to the difference between genders.
What are the symptoms of Brugada syndrome?
Symptoms that may occur with Brugada syndrome include:
How is Brugada syndrome diagnosed?
Your healthcare provider may think you have Brugada syndrome if you have any of the above symptoms not explained by another more common condition. They may also suspect it if you have a family history of the disease. Or an unexplained sudden death in the family. An electrocardiogram (ECG) can help diagnose the disease. People with typical ECG features are often diagnosed with this condition if they have had:
Genetic testing can also be done to help diagnose the condition.
You may have a test called a drug challenge if the diagnosis is unclear or if you are found to have the Brugada ECG pattern but have no symptoms. This is done in a hospital setting with professional supervision. You are given a medicine that blocks sodium channels. Then several ECGs are done to look for changes in.
First-degree relatives of someone with Brugada syndrome should be screened. This may include at least a health history, physical exam, and an ECG. Genetic screening may also be used.
How is Brugada syndrome treated?
Currently, there is no cure for Brugada syndrome. But there are ways to protect people from the dangerous consequences of the disease. An implanted cardioverter defibrillator (ICD) can help prevent sudden death linked to Brugada syndrome. When this device detects the start of an arrhythmia, it will either try to stop it with pacing or deliver a shock to reset it back into its regular rhythm.
Medicines may also help prevent arrhythmias. Another possible, but rare, treatment choice may be a cardiac ablation. In this procedure, a small area of heart tissue found to cause the dangerous arrhythmia is destroyed. Discuss all choices with a qualified healthcare provider.
It's also important to stay away from certain medicines that can make Brugada syndrome worse.
What are possible complications of Brugada syndrome?
The most serious complication of Brugada syndrome is sudden death. This often occurs while the person is sleeping.
What can I do to prevent Brugada syndrome?
Many cases of Brugada syndrome are related to a genetic defect. It's not possible for you to prevent inheriting this condition. But identifying the condition is key to preventing its possible complications. You may first want to talk with a genetic counselor if you have Brugada syndrome and plan to have children.
When should I call my healthcare provider?
If you have any symptoms of ventricular arrhythmia, call 911 and get emergency medical help right away. See a healthcare provider for testing if you think you may be at risk for Brugada syndrome because of your family history or other reasons.
Key points for Brugada syndrome
Brugada syndrome is a genetic disorder that causes an irregular heartbeat.
It can be either inherited or acquired.
Genetic testing can look for a mutation, such as with the SCN5A gene, that may help determine your risk.
An implanted cardioverter defibrillator (ICD) may be considered to prevent sudden death linked to the syndrome if Brugada syndrome is diagnosed.
Get emergency medical help right away if you have any symptoms of ventricular arrhythmia.
Tips to help you get the most from a visit to your healthcare provider:
Know the reason for your visit and what you want to happen.
Before your visit, write down questions you want answered.
Bring someone with you to help you ask questions and remember what your provider tells you.
At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you.
Know why a new medicine or treatment is prescribed, and how it will help you. Also know what the side effects are.
Ask if your condition can be treated in other ways.
Know why a test or procedure is recommended and what the results could mean.
Know what to expect if you do not take the medicine or have the test or procedure.
If you have a follow-up appointment, write down the date, time, and purpose for that visit.
Know how you can contact your healthcare provider if you have questions, especially after office hours or on weekends.

domain: biology


The property forms part of a renovated terrace of 19th century properties just off Paradise Street within Liverpool City Centre. The property is a short distance from Liverpool One Retail Development, and the Kings Dock and Waterfront.
The premises comprise fully fitted modern ground floor comprising of a main office or shop area with shop frontage, a private office, a kitchen and WC, with a rear door to enclosed courtyard.
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Some policymakers are questioning the Air Force’s next-generation air-launched cruise missiles, called Long-Range Standoff weapons, which are crucial to sustaining the deterrent credibility of the manned bomber fleet. These missiles are hard to detect with radar because of their small size and low-altitude flight profile, and thus can penetrate heavily defended air space. Long-Range Standoff weapons reassure allies and provide a unique and flexible dimension of U.S. nuclear deterrence by allowing the ability to signal intent and control escalation when facing adversary air defenses. New air-launched cruise missiles will be equipped with modern technology and far more accurate than the ones we have today. The president will thus have more options in an extreme crisis if a limited nuclear war were to occur. I have written a commentary for The National Interest here.
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Just before E3 kicked off, Square Enix finally gave us a set release date for Kingdom Hearts 3 and it will be releasing for PlayStation 4 and Xbox One on January 29th 2019, assuming that the game suffers no further delays.
While many had hoped that the game will perhaps release late this year, at least on the bright side, we have a newly confirmed release date with hopefully enough time to iron out any development issues the game might encounter between now and then. Director of Kingdom Hearts 3, Tetsuya Nomura had this to say on the release date announcement “”We’ve announced the release day for Kingdom Hearts 3 ahead of E3 at the Kingdom Hearts Orchestra World Tour. I’m sorry that we’re asking for a little more time than initially planned. Please look forward to other information, including a few trailers at E3. Thank you.”
Speaking of E3, during the Xbox conference, we got to see a brand new gameplay trailer for Kingdom Hearts 3. As well as showing-off our team of heroes, much of the trailer was featured in the Frozen universe and included the characters Elsa, Anna, Olaf and Kristoff. We also got further brief glimpses of the Toy Story, Wreck it Ralph and the Tangled universes and more. You can watch that very gameplay trailer in question below.
Once more, Kingdom Hearts 3 will release for PlayStation 4 and Xbox One on January 29th 2019. Are you content with this delay? Let us know across our social media channels.

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Two Estero residents have a lot to be thankful for, in large part to the presence of an Automated External Defibrillator (AED) and some well trained friends. On March 12, 2008 a gentleman collapsed on the tennis court at Riverwoods Plantation in sudden cardiac arrest. Residents attending the tennis match from both Riverwoods Plantation and Corkscrew Woodlands rushed in to action providing live saving skills including a shock from an AED.
Automated External Defibrillators (AED) are used in cooperation with CPR and administer an electric shock to a victim of sudden cardiac arrest. Built in computers in the device assess the patients heart rhythm and determine if a shock is needed. It then indicates to the operator whether a shock should be administered or CPR should be continued. The American Heart Association reports that CPR alone will save only 20% of those suffering cardiac arrest, but a combination of CPR and the use of an automatic external defibrillator within 4 minutes of an attack will save a victim 80% of the time. AED’s can be found in a number of locations throughout Lee County.
Approximately one year prior, March 14, 2007, another person collapsed on the same tennis court in sudden cardiac arrest. Again, the residents utilized a nearby AED successfully.
Estero Fire Rescue will be honoring residents of these two communities at its April 8th Board meeting for their life saving actions. Residents of Riverwoods Plantation and Corkscrew Woodlands will be recognized for their quick actions in using CPR and an Automated External Defibrillators (AED) which resulted in saving the lives of two Estero residents.
Nancy Nier, a CPR instructor with Estero Fire Rescue and Riverwoods resident, will also be honored for her dedication to the implementation of AED’s in the community and the continuation of CPR instruction throughout Estero.
Please join us in recognizing these wonderful residents for their dedication to life safety. The recognition ceremony will take place on Tuesday, April 8, 2008 at 5:00 pm at the Estero Community Park located at 9200 Corkscrew Palms Blvd, Estero, Florida.

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Posted March 9, 2019 at 3:05 pm by Venkant1
Shri Krishna Tours and Travels – Chardham Yatra Tour Package
Shri Krishna Tours and Travels (SKT), one of the best tours & travels companies in India is set up since 1994 in New Delhi which is the gateway to magnificent north India.
In accordance with the Hindu mythology the four most holy pilgrimages of Uttarakhand namely – Yamunotri, Gangotri, Shri Kedarnath, and Shri Badrinath, collectively known as the Char Dham, are the most sacred of all pilgrimages in India and worldwide. For centuries, saints and pilgrims, in their search for the divine, have walked these mystical valleys known in ancient Hindu scriptures as ‘Kedarkhand’ if the scriptures of HINDU RELIGION are to be believed, the pilgrimage of holy centers of these four sacred spots is a life-changing event.

domain: geography


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Science Fiction Publications (in reverse order by date)
Information about the genre will be added in the near future.
Below are all the current and previous titles attributed to the author (listed in reverse chronological order):
Out of Print
What is Science Fiction?
Most commonly it takes place on Earth or in space and uses real or imagined technology as a part of the storytelling. We like stories in this genre to be lengthy and immersive in its world building with multiple characters and where problem-solving is key to the story's outcome. We are also open for shorter faster-paced books. It may be referred to as alien contact, space opera, colonization, cyberpunk, dying earth. If the story takes place in the future, then at Emerentsia Publications we use futuristic science-fiction as a term. If the story takes place in current time, then at Emerentsia Publications we use near-future science fiction as a term.

domain: artistic


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The Equality and Human Rights Commission have just sent out their monthly e-newsletter. One of the topics is the Sex and Power 2011 report.
In response to the Prime Minister's call for more women to sit on the boards of Britain's biggest companies, the EHR Sex and Power report revealed that more than 5,400 women are missing from Britain's 26,000 most powerful posts as they are still being passed over for top jobs.
"The progress of women to positions of authority in Britain has been tortuously slow. This year’s Sex and Power Report an index of women in positions of power and influence shows a trend which is not abating; while women make progress in some sectors, that progress regularly stalls or even reverses in other sectors. It is a trend of waxing and waning; not one of constant upward movement.
British women are better educated than ever before. They are attending university in ever increasing numbers and achieve better degree results than men . Intelligent, competent women are flooding the junior ranks of law firms, accountancies and medical practices" Follow this link to find out more
If you are looking for Equalities Training Services follow this link and make sure your organisation is up to date with it's training.


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A mystery was recently uncovered at the Platte County Museum while one of its storage rooms was being cleared out.
Museum Executive Director Cheri Schrader said a Michigan marriage certificate dating back to 1869 was discovered, but the museum had no record of it. Pictured on the water-stained framed document were two portraits of the bride and groom. Since the piece was something the museum would never put on display, Schrader started making an effort to return the heirloom to its rightful owner.
“It had not been inventoried, so we really didn’t know much about it,” Schrader said about the certificate.
But, Schrader said she had some clues.
A metal plate on its frame read “Mr. and Mrs. H. R. Slocum." After some research, Schrader learned of a man named Hank R. Slocum, who once lived in Columbus.
According to his 1965 obituary published in The Columbus Telegram, the man was quite active in the local community. Slocum was instrumental in developing many parks in the city and was a member of the Freemasons (Lebanon Lodge No. 323), The Elks Lodge, The Lions Club, the Columbus Area Chamber of Commerce and the American Legion - having served in the U.S. Army during World War I. He was also a member of the United Fund and served as president of the board of directors in 1962.
It was the marriage of Slocum's grandparents that the certificate documented. After some more digging, Schrader came across one of his grandchildren, Jane Lindsay, of Pierce. She mailed her a letter explaining the situation and asked if the family would like the item returned.
Lindsay agreed, and on Saturday, she and her sister, Joan Schade, of Cheyenne, Wyoming, made a stop in Columbus to pick up the certificate while on their way to a bridal shower in Lincoln.
The two sisters said they aren’t sure how the marriage certificate for their great-great grandparents ended up at the museum, but they have a theory. A company was hired to clean out their grandparents' house after their grandmother was moved to a care facility out of state. The family must have left the certificate behind and the company most likely dropped it off at the museum, the sisters said.
Why it was never inventoried will probably remain unsolved.
Lindsay said she plans to show the certificate to her four sons and send pictures of it to various cousins and other relatives. She said she hopes to one day pass it on to her children who will, in turn, pass it on to theirs.
"I think it’s a great thing. I’m excited to show all my sons and somewhere along the line my grandchildren,” Lindsay said. "I’ll keep it until I’m ready to pass it on to my children. I just think it's cool that it was kept as well as it was.”
Eric Schucht is a reporter for The Columbus Telegram. Reach him via email at email@example.com.
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Solar Cookers International is hosting the 2nd Annual Sacramento Solar Cooking Festival on Saturday, July 18th from 10am-3pm in William Land Park. The event is free to Solar Chefs and to the public. We hope you can come and bring your family and friends to this fun, educational, and exciting event.
Watch a variety of foods being cooked in an array of solar cookers. On display will be all types of cookers and will include both homemade and commercially made cookers.
Cook at the event. Come solar cook in the largest outdoor kitchen in Sacramento. All solar chefs must register to cook at the event. Click here to register.
Meet other solar chefs and solar cooking enthusiasts. Exchange stories, recipes, and tips.
Build a CooKit solar cooker at our Make & Bake CooKit Class. Build a CooKit in the morning and use it to cook at the festival. Three class options available: CooKit plus roaster ($20), CooKit only ($10), and trace/observe (free). If you only want to trace a CooKit, bring a piece of cardboard minimum 36”x48”. Class begins at 9:00. Click here to register.
Learn about solar cooking. Educational displays explain the types of cookers, how they work, and why we use them. International Outreach displays explain how solar cooking is used around the world to help families pasteurize water and cook food helping them save money and stay healthy.
Listen to music performed by Solar Punch.
Make solar crafts including baked clay medallions and Shrinky-Dinks.
Play CooKit Toss and other games at the Fun in the Sun zone.
Navigate the Passport Game for your chance to win a $10 gift card and other prizes.
Shop at our Solar Cookers Store. Our on-site store will have solar ovens, solar cooking cookbooks, heat-resistant bags, roasting pans and more.
Volunteer at the event. We are in need of volunteers at the event for set up, clean up, and during the event. Please contact Cathy at firstname.lastname@example.org
Sponsor the event. We are in need of additional sponsors for this event. If you or your company would like to be a sponsor, please click here to get started.


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How have football stars such as Paulo Dybala, Mikel Arteta and Paolo Maldini been affected by the virus?
The coronavirus pandemic has swept the world and a number of footballers have been confirmed as having contracted it, forcing leagues everywhere to a standstill.
As well-paid athletes, elite-level footballers are ostensibly in a much better position to fight off the virus, but some have reported feeling serious pain and being scared.
There are a few commonly reported symptoms, but those who are asymptomatic can also be carriers and unknowingly spread it.
No place like home! Argentina duty a breath of fresh air for Messi after Barcelona strife
Partey, Xhaka and Ceballos? How Arsenal could line up with new £45m signing
Zidane, Henry… Giroud? Much-maligned striker deserves to be considered France legend
‘The worst manager in the history of the Premier League’ – How did De Boer land Netherlands job?
Some of the main symptoms include:
Loss of smell & taste
Aches & pains
Goal takes a look at some of the symptoms and experiences reported by footballers who contracted the coronavirus.
Mikel Arteta | Arsenal
Symptoms: temperature, dry cough, chest pain
Arteta explained: “In terms of symptoms, it was a normal virus for me. I had three or four days which were a little bit difficult, with a bit of a temperature and a dry cough, and some discomfort in my chest. That was it.”
‘That’s when the fear comes’ – Arteta details coronavirus experience
Callum Hudson-Odoi | Chelsea
Symptoms: “similar to a mild cold”
Chelsea and England star Hudson-Odoi recovered from the virus after spending a week-long period in self-isolation. The winger reported symptoms “similar to a mild cold”.
Hudson-Odoi reveals he has recovered from coronavirus symptoms
Daniele Rugani | Juventus
Symptoms: mild fever
Rugani tested positive for the virus, but was ostensibly asymptomatic. In a message posted on his Twitter page, he said: “You will have read the news and that’s why I want to reassure all those who are worrying about me, I’m fine.”
His girlfriend Michela Persico told Corriere Della Sera: “Daniele recorded three mild fever lines, he was at a temperature of 37.5.
“He asked to be checked and, the next day, the test was positive, but he already had no fever, nor did he have or had a cough or something else. So we didn’t expect it. We don’t have a clue how the infection happened.”
Juventus defender Rugani tests positive for coronavirus
Luca Kilian | Paderborn
Symptoms: sore throat, fever, headache
“On March 12 I had the first of my hot flushes and a day later they were really strong. Fever and strong shivers. It was then I started being really scared for the first time,” Kilian told Westfalen-Blatt.
The player added: “It took four days for the fever to drop, and after that I felt better every day.
“I’m a sportsman and in form, but I had to fight a lot against the virus. For the people who already have health issues, it could put their life in danger.”
Manolo Gabbiadini | Sampdoria
Symptoms: slight fever, headache
“I felt a little fever on the night of Tuesday March 10, but I didn’t think about the virus,” Gabbiadini said. “That night I slept badly, woke up often and in the morning my head was dizzy but I wasn’t hot. I only measured the fever out of concern and I was 37.5. I called Dr. Baldari from Samp, but again I didn’t think about the virus.
“Martina, my wife, however, suggested I ask for a swab, as we have two small children at home. The doctor came to do it and we made an appointment for the next day. On Thursday I was fine, my fever had ended. At 3pm the doctor called me to tell me that I was positive.”
Gabbiadini tests positive for coronavirus
Patrick Cutrone | Wolves / Fiorentina
Symptoms: mild, asymptomatic
Wolves striker Patrick Cutrone, who is on loan at Italian side Fiorentina, was among a number of players at the Florence club. However, symptoms were mild and those who tested positive were reported to be in good health.
Cutrone among confirmed cases at Fiorentina
Eliaquim Mangala | Valencia
“I’m feeling good and I have no symptoms associated with the virus,” said the former Manchester City defender.
Indeed, Mangala believed his diagnosis was a joke, telling L’Equipe: “I didn’t have any symptoms, I was just like every day.
“So, when Sunday morning the doctor told me I was positive, I was shocked. I thought it was a joke at first. But when he talked about quarantine, for 14 days, staying away from my kids, I understood it wasn’t a joke.”
Valencia confirm 35% of squad tested positive
Glyn KIRK / AFP
Ezequiel Garay | Valencia
“I have tested positive for coronavirus but feel very well,” said Garay. “Now it only remains to pay attention to the health authorities and, for now, be isolated.”
Valencia announce positive coronavirus cases after Garay result
Blaise Matuidi | Juventus
On Instagram, Matuidi wrote: “I am an asymptomatic carrier of the virus, aware of the privilege of being a professional footballer and as such benefit from regular and excellent medical monitoring. If it weren’t, I probably never would have known.”
Juventus star Matuidi tests positive for coronavirus
Charlie Austin | West Brom
Though he wasn’t strictly tested for the coronavirus, West Brom striker Charlie Austin fell ill and warned people to take it seriously.
“I felt like someone had chucked a bucket of water over me. I was soaking,” the ex-Southampton and Burnley forward told the Telegraph.
‘Don’t take it lightly’ – Austin expresses coronavirus concerns
Paulo Dybala | Juventus
Symptoms: cough, tiredness, mild fever, headache
“I had a bad cough, I felt tired and when I slept, I felt cold. At first, I didn’t think about what it could be but it had happened to two other team-mates and the last one was me,” Dybala said during an interview with the official AFA website.
“We had headaches, but it was advisable not to take anything. The club gave us vitamins and over time we felt better. It’s psychological. You were scared at first, but it’s okay now. These days we haven’t had any symptoms.”
Dybala tests positive for coronavirus
Paolo Maldini | AC Milan
Symptoms: dry cough, loss of taste & smell, chest pain
“It was like a slightly uglier flu. But it’s not a normal flu. I know my body. An athlete knows himself,” Maldini told Corriere della Serra.
“The pains are particularly strong, and then it feels like a squeeze in your chest… it’s a new virus. The body fights against an enemy it doesn’t know.”
Maldini expects to recover from virus ‘within a week’
Daniel Maldini | AC Milan
Symptoms: dry cough, loss of smell & taste
A statement on AC Milan’s website read: “AC Milan confirms that Paolo Maldini, the club’s technical director, became aware of contact with a person who subsequently tested positive for coronavirus and began to display symptoms of the virus himself.
“He was administered with a swab test yesterday, the result of which was positive. His son Daniel, a forward in AC Milan’s youth team who had previously been training with the first team, also tested positive.”
AC Milan legend Maldini & son test positive for coronavirus
Marouane Fellaini | Shandong Luneng
Fellaini said on Twitter: “Dear friends, I have been tested for coronavirus and my test result is positive.
“Thanks to the fans, medical staff and the club for their care and attention. I will follow the treatment and hope to return to the game as soon as possible. Please everyone stay safe.”
Former Man Utd midfielder Fellaini tests positive for coronavirus
Recber Rustu | Turkey
Symptoms: fever, loss of appetite, fatigue, cough
“Everything was normal when he suddenly developed symptoms really fast and we are still in shock. These are critical and difficult times,” Rustu’s wife Isil said.
Turkey idol Rustu hospitalised with coronavirus
Pauline Peyraud-Magnin | Arsenal Women
Symptoms: fever, headache, chest pain, fatigue, loss of taste & smell, breathing difficulties
“I had a lot of symptoms related to this virus: fever, cold, constant headache, respiratory discomfort, immense fatigue and loss of taste and smell. I checked a lot of boxes,” said Peyraud-Magnin.
“My mother told me that I had the symptoms of coronavirus, and I’m starting to really be afraid. The difficulty in breathing followed. There, I really freaked out because it was stressful, the stress causes hyper ventilation and so on.”
‘I was frightened’ – Arsenal goalkeeper Peyraud-Magnin reveals coronavirus fear
Sir Kenny Dalglish | Liverpool
Dalglish had been in hospital for treatment of gallstones when he was confirmed as having coronavirus. However, the former Reds player and manager was asymptomatic.
Liverpool legend Dalglish tests positive for coronavirus
Junior Sambia | Montpellier
Symptoms: Breathing difficulties, diarrhoea
Montpellier midfielder Junior Sambia was placed into a coma and had to receive respiratory assistance after testing positive for coronavirus, but was subsequently brought out of the coma and was able to breathe on his own.
“He really respected confinement. He did everything well. He must have contracted the virus while shopping,” Sambia’s agent Frederic Guerra told Le Parisien. “He suffered three days of severe diarrhoea – like gastroenteritis. Then, on Tuesday morning, he went to the hospital.
“I reached him when he was on an IV. He had just received the Covid-19 test result. This one was negative. He was due to leave on Wednesday, then his condition worsened with his lungs.
“It grew more complicated in transit. He went back to the same hospital, then he changed hospitals twice before being placed in an artificial coma.”


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Big companies widen lead in AI research
The cripplingly high computational costs of top-notch AI research increasingly means that only a handful of big companies are able to do top-flight AI research.
Why it matters: AI will do more than any other technology to shape our future. If only the Googles and the Microsofts of the world have the resources needed to move the field forward, it will solidify their power — and possibly strangle innovation.
By the numbers: It likely cost the Microsoft-funded research group OpenAI more than $10 million to train GPT-3, its cutting-edge, new natural language processing algorithm, according to the annual State of AI Report published Thursday.
- That's because these models are created by essentially throwing ever-increasing amounts of data at the thorny problems of AI. Processing all of that data takes lots of computational power — and compute costs money.
Of note: OpenAI was originally founded as a nonprofit with the purpose of pursuing AI research for the benefit of all humanity.
- But last year it set up a for-profit arm and accepted a billion-dollar investment from Microsoft.
- Last month Microsoft announced it would be exclusively licensing GPT-3.
Context: In the future the costs of developing these massive models may become prohibitive even for the richest tech companies.
- The report found that without major research breakthroughs, reducing the error rate for ImageNet — a massive database used for visual recognition research — from 11.5% to 1% could cost $100 billion billion. (Yes that's two "billions.")


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The US works like Sweden. Presidents and politicians change but policy stays the same.
Trump becoming president made Deep State more visible to ordinary people since Obama and Deep State acted like one.
Assad: Why talk to Trump if he doesn’t control the US? (Russia Today, RT)
we don’t think the president of that regime [US] is in control. We all believe that the deep state, the real state, is in control, or is in control of every president, and that is nothing new. It has always been so in the United States, at least during the last 40 years, at least since Nixon, maybe before, but it’s becoming starker and starker, and the starkest case is Trump.
Bashar Hafez al-Assad, President of Syria -1- -2-
Putin (Oliver Stone)
Putin (Le Figaro)
Skripal case: Neither UK nor Russia will gain from this incudent. Russia loses reputation by the accusations of using nerve gas agsins civilians, UK loses reputation by making ghe unreasonable accusations. Someone else must have orchestrated the attack. Someone else is NWO/Deep State. (Earlier the term ZOG was used. It has a bad ring and focuses on Zionism. Globalism is wider than Zionism. The term was maybe constructed by false flag trolls. Jokingly the world globalist network is sometimes called Skynet, referring to an AI network controlling the world trying to exterminate mankind, in the movie sequel Terminator. Another term used is “shadow government”.
Continue reading “03.1.002.018.00.0100 Deep State, New World Order, NWO; Bilderberg; nätverk, networks, congress/president power balance; Conspiracy theories”
Bay of Pigs
Many believe that if The New York Times had not withheld crucial information, the failed (and for the US, embarrassing) invasion of Cuba would never have taken place.
It is very difficult to investigate situations like Watergate or Bay of Pigs. Any search using Google will be under heavy globalist agenda, in this case often protecting The New York Times.
The New York Times and The Washington Post contributed significantly to the ban of Russian athletes during the Olympic Games in PyeongChang in 2018. -1- -2- -3-
The Rodchenkov affair had notable repercussions in media over the world. Based on extremely weak evidence Russia was accused of systematic doping in sport. Jewish networks were activated: The producer of the film Icarus (of Jewish descent) contacted the New York Times (owners of Jewish descent) and the newspaper, together with the Washington Post started a spread of information where other papers followed. See “newspaper of record“. (Therefore antidoping has later been targeted by political actors.
Other similar attacks on Russia, also based on false evidence had much less impact, like “chemical weapons used by Syria”, “nerve gas attacks in UK/Salisbury”. To avoid realizing the differences between people of different ethnicities, Africans are tested harder than others for doping violations. Russian athletes must prove their innocence where others have not to.
The New York Times (reporter Judith Miller) contributed significantly to making the US invasion of Iraq in 2003 happen. The evidence were false.
Continue reading “03.1.005.001: Media: The New York Times, US East Coast”

domain: politics


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One of the oldest living WWII Veterans is in Omaha this weekend. 99-year-old Sidney Walton.
Walton is on a "no regrets tour" with his son, Paul.
He regrets turning down the opportunity to meet Civil War veterans in 1941, at New York’s Central Park, just before he joined the Army.
Now, his mission is to give everyone in the country, a chance to meet a WWII veteran while they still can.
“Because I naturally like to meet people,” Walton said.
“For years people have been coming up to my father and thanking him for his service,” Paul Walton said. “But he is also opening himself up to people that have never had an opportunity to meet a WWII Veteran."
Walton is meeting with the governors of all 50 states. Monday, he will meet with Gov. Pete Ricketts in Lincoln.
His last stop is the White House in February, on his 100th birthday.
Walton would love to meet as many people as possible this weekend in Omaha. He will make stops at the Old Market and Aksarben Farmer’s Markets, Arts Festival and Santa Lucia Festival.


Praetorian Guard Intercom System 4G Single Button - AES Global
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Manage access and video chat with your visitors in real-time from your smart-phone, whether you are at home or away!*
The Praetorian Guard range is available in either gloss acrylic or stainless steel finish without keypad.
How Does It Work?
It connects to the internet through a 4G compatible SIM installed in the 4G modem. Simply connect the intercom to the 4G modem via Ethernet cable (supplied), connect power and log on with provided credentials.
Control and manage your intercom system via free smartphone app for homeowners on Android and Apple iOS.
- Video chat with your visitors and grant access in real-time from anywhere in the world*
- Ultra-clear HD colour camera with night vision and IR cut filter
- Supports multiple users, ideal for large families or small businesses
- Connect up to 8 maximum devices / users per intercom ID (incl ADMIN user, for optimal performance 4 maximum is recommended)
- Visitors can leave voicemail style video messages when unanswered, ideal for times when you might miss a call
- Easily playback missed calls so you know exactly who visited
- 120° field of view providing exceptional image quality and coverage
- Infra-red night vision illuminators
- Built-in motion sensor function
- Waterproof Mylar 1.5W speaker
- Security screw access
Dependable and Adaptable
- Coin cell battery retains important system settings while the intercom is off (such as date-stamp)
- Easily adjust the volume of the intercom€™s external speaker to suit the environment
- SD card storage saves all video & picture files locally (16GB included)
- Illuminated IP67 button(s) for ease of use in the dark
*Please Note: Some features will be free for 12 months then require a subscription.
New Praetorian Guard App
- Easy to use free smartphone app for managing and interacting with your intercom system
- Available on Android and Apple iOS devices
- Historical log of activity events so that you can review comings and goings
- 7 day time schedule for auto opening
- Get alert notifications when the motion sensor detects movement or your gate / door is triggered
- Sync device time to device
- View the HD camera feed from your intercom in full screen mode


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As South Dakota and other major meat-producing states struggle to combat Coronavirus, their factories are being forced to shut down due to the high infection rate amongst its workers. This closing has and will create a food shortage of unknown size, euthanize a large amount of livestock and potentially infect more people with Covid-19.
First, the closing of meat factories will create a food shortage that will impact the nation. The meat factories that have already closed will create a predicted shortage as soon as the beginning of May, the effects will soon be felt in the coming days. This shortage is likely to impact meats such as poultry, beef and pork; those often found at meat counters. The likely shortage will not impact frozen meats as they were packaged far before any discussion of such shortages. The production of pork and beef is already down 25 percent since the outbreak of Covid-19, a statistic that has shocked many into buying more meat than necessary in anticipation of the coming paucity. This has led to meat prices rising, with an estimated one to three percent increase in the coming months.
Due to the closing of major livestock farms amidst the Coronavirus outbreak, many are forced to euthanize the animals within them. The farmers, who are unable to go to the farms to feed the animals are now being told to kill all of their animals. On top of the unfortunate nature of the event, thousands of pounds of food will go to waste that could be put into circulation in the United States.
“It is really sad that so many animals are being killed for absolutely no reason,” freshman Patrick Heydasch said.
In an attempt to counter the factories closing and likely food shortages, President Donald Trump signed an executive order stating that meat factories are vital to the nation and are allowed to stay open, despite the factories becoming an epicenter for virus outbreaks in many mid-west states, causing the food shortages in the first place. This means that the factory workers will be allowed to work in environments that have recently been the site of outbreaks of Covid-19, which has evoked an abundance of backlash from unions who say that it will jeopardize the well-being of about half a million workers. The workers are put next to conveyor belts, often shoulder to shoulder with other workers, which means that they have no possibility of following the social distancing recommendations.
In short, due to the closing of meat factories nationwide, there has been an inflation in the price of meats, anticipating a likely meat shortage nationwide. Also due to the closing of the factories, they are being forced to euthanize all of the livestock, wasting thousands of pounds of food. The factories are legally allowed to open, but could potentially spread Coronavirus to many of the workers.

domain: food


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'Rama Readers! You ready for tomorrow's reviews, today? Best Shots knows all, and we are ready to pierce the veil of time and space for your reading pleasure! So let's kick off today's column with the latest revival from Rob Liefeld's Extreme Studios, Supreme #63...Supreme #63
Written by Alan Moore
Art by Erik Larsen and Cory Hamscher
Lettering by Chris Eliopoulos
Colors by Steve Oliff
Published by Image Comics
Review by Rob McMonigal
'Rama Rating: 10 out of 10
In the revived world of Rob Liefeld’s Extreme Universe, Supreme is the mightiest superhero of all. Yet all it might take is a comic book to destroy him, when it falls into the hands of an old foe. The very medium we’re reading might be the Kryptonite for this Superman-like figure as we explore the insanity that is Daxia, a haven of sorts for the all the evil Daxes that ever existed, as they plot to ruin Supreme’s bliss once and for all.
Who says that Grant Morrison is the only writer allowed to play with old comic book story concepts? While Morrison might be the most notable writer weaving modern narratives out of Golden, Silver, and Bronze age adventures with concepts such as , for my money, Alan Moore will always be the best at doing so. Sadly, it’s not something that we see from Moore these days, but now we get one last look at the genius of an Alan Moore superhero comic with this final story arc in the resurrected Supreme.
Starting off from the credits page with an old-school feel (“At Last! The Comic you’ve dreamed about is here!”), Moore quickly shows that he is once again going to demonstrate his mastery of the medium by using an homage to the infinite worlds concept to set up what looks to be a bloody modern battle with as many Easter Egg character references as Erik Larsen and Cory Hamscher can sneak in. What looks to just be an amusing sidebar turns into a major plot point, as the Dax of “our” world quickly realizes that not only are there multiple Daxes—there’s a world of Supremes to be attacked, too!
Showing an amazing pacing ability, Moore stretches this idea across the entire comic, using the time to both remind readers of the insanity, cruelty, and evil of Dax (and his analogues) as well as create as idyllic a situation as possible for Supreme, so that when the two characters eventually collide, the loss for our hero will be all that much greater. In just a few scenes, Moore drops hints that leave the reader guessing, especially in relation to Diana Dane and her role in this story. We end with a splash page that gives a sense of the scale of the battle to come and also leaves you wanting to count down the days to the next issue.
As good as Moore’s script is here, a lot of the credit for this book’s success needs to go to Larsen and Hamscher for their ability to match Moore’s ambitious script with visuals that rival the work of Gene Ha and Zander Cannon with Moore on . I don’t know if it was Moore or Larsen who came up with the multiple little nods and winks to characters in other superhero pantheons, but they show up fast and furious in the Dax sections. I don’t want to ruin the fun of discovery, but anyone unsure about this comic should be aware there’s an evil version of Howard the Duck that features prominently. The final splash page I mentioned will keep eagle-eyed readers guessing for ages, as the art team provides a few obvious homages and then gets far more subtle and obscure as the characters blend into the background. I cannot wait to see some of them in action!
It’s not just in the little surprises that this comic excels, however. While Larsen inking his own work can sometimes result in flattened figures that don’t quite look fully formed, here his visuals almost pop off the page, which I attribute to Hamscher’s inking. He rounds things off to give depth while preserving the distinctive look of Larsen’s expressive faces, dynamic poses, and hulking figures. Even the dialogue-heavy sections (and there are many, because this is a Moore script) are given fluidity due to clever artistic choices and smart camera angles. The art changes viewpoint and perspective frequently, which I thought was a nice touch. You can tell what a character is thinking by how they look and what they are doing in each panel. Even the sex scenes are tasteful, doing a lot by showing little.
Supreme #63 is the book of the week for me. It shows what can be done when craft and care are taken, from plot to script to art. Is it May 2 yet?Swamp Thing #8
Written by Scott Snyder
Art by Marco Rudy, Yanick Paquette, and Nathan Fairburn
Lettering by Travis Lanham
Published by DC Comics
Review by Lan Pitts
'Rama Rating: 8 out of 10
The tension between Sethe and Swamp Thing has been culminating for quite sometime now, and yet it goes continues on in Swamp Thing #8. Now you have to keep in mind that Alec Holland's identity crisis was a couple of issues in there as well. Having eight issues out of the box, I didn't think it would have taken this long to get to this point of the story, but Snyder's style of slow-roasting until they're just right has paid off in the past.
You might have seen Swampy get a new, more armored look to him in certain previews. The bark antlers as a sort of Norse crown or helmet is a nice touch. Marco Rudy does a great job of helping Yanick Paquette here because Paquette's pages are some of the strongest he's done yet. It reads as a typical Snyder-made comic with heavy captions and a lot of action, but not a lot of dialogue.
Paquette's art speaks volumes here with his heavy lines and added with awesome depth by Nathan Fairburn on colors. Paquette has gotten the whole macabre imagery down pat. His broad linework still remind me of Ryan Sook, but they are distinguished as his own. The double-page spreads are wonderful to really dive into as they let him do his thing and it looks like no other DC book out there. Fairburn's palette of heavy reds and yellows make Swamp Thing pop out even more.
Snyder continues to show how powerful Sethe's magic is, and Swampy fights to the best of his new abilities, but that's a portion of the issue. Most of the issue is just Sethe proving his power to Holland and the chaos he's created. I do like the reverse coloring on their dialogue, giving even more hints that these forces are in direct opposition. It's small, but a nod to the attention to detail this creative team puts in this book.
Swamp Thing has been a great book thus far, but it seems almost a little dragged out at this point. This is a solid issue, but I feel that the last issue and this issue could have been a single issue. Now, the cliffhanger in this one gives an inkling that things could be wrapped up nicely in the next issue, but I doubt it. Then again, we've gotten so accustomed to 3-4 issue arcs, maybe one nice elongated run to things will spice things up and allow the story to breathe accordingly.
Danger Club #1
Written by Landry Q. Walker
Art by Eric Jones
Colors by Michael “Rusty” Drake
Letters by Richard Starkings and Jimmy Betancourt
Published by Image Comics
Review by Erika D. Peterman
’Rama Rating: 9 out of 10
In comics, every teen hero reaches a point where he or she wants to prove capable of saving the world, or at least the day, without adult supervision. It’s a timeless theme that has fueled many excellent stories.
But what if the elders are completely out of the picture, maybe for good? What becomes of the sidekicks, to say nothing of the world, that they left behind?
Those questions are at the center of Danger Club #1, which is yet another top-notch offering from Image Comics. The Earth's young capes are in a dark place after the disappearance of their mentors, who were last seen departing for space to fight a yet-unnamed evil. Apollo, a super-teen with a god complex, has exploited their fears so well that some are falling all over themselves to follow him. But the members of the Danger Club, led by Kid Vigilante, are not having it. Actually, Kid Vigilante isn't having much of anything. Confident and extremely tough, he provides the book’s most shocking moments. The first rule of Danger Club? Do not make him hit you.
Writer Landry Q. Walker sets a fast pace and doesn’t waste a lot of time with setup or character introductions. This is an efficient, action-packed story that makes the most of the comic’s premise. Left to their own devices, a bunch of agitated, powerful youngsters are fighting among themselves, jockeying for position and abandoning their ideals. With apologies to The Who, the kids are not alright. I'm thinking “Lord of the Flies,” only with teleportation, giant robots and sonic blasts. Walker has created quite an interesting cast of characters to develop.
Eric Jones’ art here is fantastic. Check the opening page, done retro style. The scenes in the arena where Apollo holds his messed-up auditions for sycophants hum with energy. Most importantly, Jones never lets us forget that children are the players. Everyone looks about 14, tops, making the violent scenes uncomfortably unforgettable. The color scheme is too heavy on blues, purples and grays for my liking. However, there are bursts of color that burn brightly against the moody backdrop.
With a smashing first issue to its credit, Danger Club has all the makings of a high-quality hit. Join up.
Written and Lettered by Paul Grist
Art by Paul Grist and Bill Crabtree
Published by Image Comics
Review by Rob McMonigal
‘Rama Rating: 7 out of 10
If spraypainting over a school logo gets you detention, what’s the punishment for fighting the legacy of a super-powered human who’s supposed to be dead when the teacher steps out of the room? Young and unintentional hero Owen Craig might just find out in third issue of Paul Grist’s unabashed throwback superhero comic Mudman.
A longtime friend of mine put me on to Paul Grist with his look at UK-themed superheroes, and I quickly became a fan of this new series that debuted late last year. Grist has mentioned previously in his introduction to the series that he is a huge fan of comic books. Not graphic novels or issues written for trade, but things meant to be read serially and individually. This is obvious in the plot and pacing of this issue, which features four parts, all of which could have been stretched into their own comics had Grist chosen to decompress the storytelling.
Mudman #3opens with a fight scene between two characters that clearly know each other, though we do not. They go out in a mysterious blast, but it won’t be the last we see of a strange metal toy lost in the fight. I really like how this sequence, in only a few pages, expands the world of Owen Craig in the way that pages of exposition could not. Unfortunately, however, it’s not Grist’s best work artistically. With his thin, angular lines, Grist’s style always looks like it belongs in the Silver Age of comics and frequently reminds me of Steve Ditko, especially here due to the teen hero protagonist. In this section of the story, Grist’s weaknesses hurt the actions he’s chosen to show the reader. It’s like Grist was taking photos and picked all the wrong ones to keep. I think part of that is due to trying to show too much in too little space—the fight is almost too compressed.
Fortunately, things improve as we move to what Stan and Jack might have labeled “Part 2!” of the story. The reader gets a great framing sequence reminding them of who Mudman is and why his story is interesting: Owen has no idea how he got his powers, what they do, or just how dangerous being a superhero can be. Featuring creative use of panels and even narrative boxes, this second section sets up the action for the rest of the comic, gives us character development, and, in complete contrast with the first part, every panel displays just what makes Grist’s art both unique and captivating. Some readers might have a problem with the heavy use of the narrative boxes, but I think they work here, especially since they’re placed within the art itself instead of obscuring it.
Grist has worked hard in this series to show that Mudman has a life beyond his adventures and that pays off in the third section of this comic. An ordinary detention quickly turns deadly as Grist links the first two parts of the comic into a fight scene that not only ties Owen’s friend Newt into the story but also makes great use of the Chekov’s gun idea, both from this issue and prior ones. (Speaking of Chekov, try not to be too angry that Paul Grist forgets how to spell Gene Roddenberry’s classic TV show.) My favorite part of the battle is the completely placid look on the face of the killer bird-spider as it tries to rip Owen and Newt to shreds. I do wonder why Bill Crabtree didn’t adjust the colors for this part, because it’s heavy on green and different hues would have make the action stand out better, I think.
Cleverly placing the coda to this issue after the letters column, Grist sets up further stories with two quick pages that bring everything full circle. Owen is in for more trouble than he’s ready for, a cheerful killer gets added to the cast, and we’re ready for the next issue. This is all done in just
In this era where some arcs bloat over five or six issues without doing much, Paul Grist’s work is a breath of fresh air, showing that a comic can do a lot in just 28 pages. While the art isn’t perfect, Mudman continues to show that sometimes the old ways of storytelling are still the best.Got a comment? There's lots of conversation on Newsarama's FACEBOOK and TWITTER!

domain: literature


This is the moment a furious driver punches another motorist several times through his open window in a brutal road rage assault.
A man jumps out of his car and lands a number of blows on his fellow motorist sat in the vehicle behind - who is unable to get away while stuck in traffic.
The clash ends when another passing motorist intervenes to calm things down.
Dashcam footage shows how initially a Vauxhall Corsa and BMW were vying for position on the A127 flyover in Southend, Essex.
The black Corsa speeds in to the inside lane before swiftly swerving back into the outside lane in front of the BMW.
As traffic slows, the BMW tries to get past on the inside lane but is blocked off by the other car, not once but twice.
Having come to a standstill, the driver of the Corsa jumps out of his vehicle to confront his fellow motorist.
After a short exchange of words, the Corsa driver - wearing a navy t-shirt, grey jogging bottoms and red shoes - slams the BMW door shut before launching a trio of punches through the window.
He then opens the door again to throw a further four devastating blows before being interrupted by another driver and the passenger in his own car.
The video was shot by a parcel courier – who wishes to remain anonymous – while driving in his van on Friday, June 17 at around 11.55am.
The courier said: “When I pulled on to the flyover, the two cars in question came into the camera view from over the flyover on the right hand side.
“The smaller Corsa was tailgating the BMW and then cutting in front at the top of the video abruptly."
“I can only assume the drivers had issues over giving way coming onto the flyover as it’s only a single carriageway," the courier continued.
“Unfortunately I could not hear what was being said between the two nor what the black van driver said to stop it.
“The traffic built up pretty quickly so I did not see what else happened with the vehicles.”
Mirror Online has contacted Essex Police for a comment.


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text:
Menu Week of June 26
|Images captured while walking @ Hidden Pond|
It is officially summer in Maine.
There are so many things I love about summer.
Especially culinary reasons!!
The pizza oven and grill get uncovered , there is already fresh peas and pesto.
Monday: Grilled Cheddar Burgers and Kale Chips
Tuesday: Lemon Thyme Chicken Asparagus
Wednesday: Picnic In The Park ( Live Free Concert Night)
Thursday: Honey Sesame Salmon In Foil
Friday : Swedish Meat Balls
Saturday: Loaded Greek Chicken Salad
Sunday: Steamers and Corn on the Cob


text:
4 signs housing is on the mend (finally!)by Keith Gumbinger
Low and stable mortgage rates and a modestly improving economy are starting to produce positive effects on the nation’s housing market. While starting from extraordinarily low levels, and though improvement is still of course tenuous, there have been accumulating signs of improvement for months.
If the economy can continue to nudge forward for a while longer without some new or already-known catastrophe to derail it, we just might have ourselves a housing market worth talking about when spring rolls around.
4 signs housing is on the upswing
1. Mortgage rates: Granted, mortgage rates overall did rise modestly last week, but a three-basis-point increase off record lows is nothing to worry about.
According to HSH.com’s broad-market mortgage tracker–our weekly Fixed-Rate Mortgage Indicator (FRMI)–the overall average rate for 30-year fixed-rate mortgages (conforming, nonconforming and jumbos) rose by three basis points (.03 percent) last week, climbing to an average 4.22 percent, for the week ending Jan. 20.
The FRMI’s 15-year companion also increased by three basis points (.03 percent) to finish the weekly survey at an average of 3.53 percent.
Important to homebuyers and low-equity-stake refinancers, FHA-backed 30-year mortgages retreated by another two hundredths of a percentage point to 3.86 percent, while the overall average for 5/1 Hybrid ARMs gained a single basis point to end at 3.04 percent.
Mortgage rates have moved gently off record lows, which is to be expected given the warmer economic climate.
2. Home sales and starts: Sales of single-family homes, traffic in showrooms and sales offices, and expectations for sales over the next six months are all on the rise. Even if there is a long way to go, the fact that we are moving in the right direction is a welcome sign of recovery.
Starts of new homes were down by 4.1 percent in December, but that minor dip does not derail an almost steady upturn in residential construction which began in March 2011. The 657,000 rate of initiation was off of November’s pace, but permits for future activity were almost level, and starts of single-family homes continue to ratchet higher; at 470,000 annualized, this would be counted among the highest annualized rates seen over the past couple of years.
Sales of existing homes are bouncing higher, too. The National Association of Realtors reported a 5 percent rise in sales in December, with the total landing at a 4.61 million (annualized) rate of sale for the month. It was the strongest annualized figure since early 2011.
3. Builder sentiment: We are by no means at a breakeven level, let alone healthy, but the indicator of builder sentiment from the National Association of Homebuilders continues to rise. The reading of 25 for January was about half the neutral level of 50, but almost double the reading of 13 seen as recently as June. In fact, the overall reading was the highest in four years.
4. Mortgage apps: At least a few headlines were made by the 23 percent increase in mortgage applications reported by the Mortgage Bankers Association of America for the week ending Jan. 13. While of course welcome, our experience is that such a flare is typical for the first full week of January, as some pent-up demand occurs during the busy holiday season. Typically, if interest rates have remained favorable from about Thanksgiving to New Year’s Day (and they are certainly all of that at the moment) borrowers finally get a cleared spot on their calendar to execute a transaction. This is especially true for refinancing (+26.5 percent) but also for purchase transactions (+10.3 percent). Such percentage increases probably won’t persist, but instead may be replaced with more modest but steady gains in the coming weeks.
What’s in store for this week?
Yields on 10-year Treasuries finished the week ending Jan. 13 on a downward note, and mortgage rates were at record lows again through into Wednesday morning (Jan. 18). However, the reverse was true last week, with Treasuries ending on a high note, and nudging mortgage rates off record lows.
While some of this increase in underlying costs will probably be absorbed into still-wide spreads, a bit of it may make its way into rates this week, which would mean another slight increase. No real movement, but probably a couple of basis points upward is to be expected, based on where we are at the moment.
The Fed meets this week to discuss policy and communication strategies. It’s a two-day affair, finishing on Wednesday. Expect no change to policy, perhaps some more frank discussion about where rates are expected to be going, a more upbeat assessment of the economic situation, and a cautiously hopeful tone overall.


text:
Lima, the city where it almost never rains and where the earth trembles, is built, destroyed and rebuilt over the centuries, it is on its pre-Columbian foundations where the Spaniards founded the City of Kings during the Conquest in 1535.
Today, the capital of Peru is an expanding metropolis of 10 million people that unfolds to infinity on the Pacific coast, at the foot of the Andes.
When visiting the UNESCO World Heritage Historic Center, you will observe the architectures that bear witness to the different stylistic tendencies that influenced the construction of the city.
A few cuadras around the Plaza Mayor you will pass the entrance doors to discover the courtyards, the shaded galleries and the ornate balconies that overlook the busy streets of the city.
Baroque churches and convents, casonas, neoclassical and modern buildings constitute a heart of rhythmic city, contrasted, varied and colorful, as well as Peruvian culture.
Discover this tour in Lima, the capital of Perú, and enjoy the historical center and architecture of the city. Our tours are focused on architecture and urbanism and they are perfect for architecture lovers, experts and professionals as well as groups and student trips. Enjoy with Artchitectours guided visits around the world, made by professional guide-architects who will come along with us throughout the itinerary.

domain: travel


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text:
Relying solely on those refreshing icy drinks to cool your body isn’t the most appropriate way to fight the scorching heat. You can add some of these cool vegetables that are loaded with vitamin to you daily by ActiveDeals"> diet chart. A list of eight amazing coolants to refresh your mind as well as body is discussed by Dr. Shilpa Mittal who is a nutritionist, diet consultant and founder of Nutrilife Health Management.
1. Indian vegetable for summers – Snake Gourd (PADVAL)
This particular vegetable acts a coolant for the body. The various uses of which can be listed as - correcting disorder, processing by ActiveDeals"> nutrition and can also restore the normal functioning of the body. The production of the bodily fluids and curing dryness are some of the functions stimulated by Snake Gourd. The fresh juice from its leaves is also extremely useful for people with heart conditions such as palpitation in the heart on physical exertion.
2. Indian vegetable for summers – Pumpkin (KADDU)
Efficient cooling and diuretic properties are possessed by this particular vegetable called pumpkin.
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3. Indian vegetable for summer – Bitter Gourd (KARELA)
Rashes, boils, fungal, infections and ring-worms can all be cured by bitter gourd. Bitter Gourd can also help in controlling other conditions like by ActiveDeals"> diabetes, hypertension and apart from all this it can help in increasing immunity on a general level.
4. Indian vegetable for summer – Bottle Gourd (Dudhi)
The major component of Bottle Gourd is water which can help you in dealing with heat and is also advantageous for various problems related to stomach for example acidity, which is most common during the summers. Extreme loss of sodium can be prevented by Bottle Gourd which in turn helps in preventing exhaustion.
5Bitter Gourd can also help in controlling other conditions like by ActiveDeals"> diabetes, hypertension and apart from all this it can help in increasing immunity on a general level.
5. Indian vegetable for summer – Amarnath Leaves (Chawali Bhajjji)
Besides being typically nutritious, summers leaves are also known to be extremely nutritious. It is also famous by various other names like – Chinese spinach, cow pea leaves. Chawali ka pataa or Chawali Bhajji.
· High sources of vitamin A, vitamin B6 and vitamin C are loaded in this vegetable.
· Those by ActiveDeals"> hot summer months that are difficult to fight can be made tolerable by using this wonderful cooling vegetable.
· It is also known for curing other conditions like – respiratory disorders and malaria.
6. Indian vegetable for summer – Ridged Gourd (turai)
This vegetable which is readily available during the summers is one of the best in purifying blood, lowering the levels of sugar in the blood and is also good for your stomach and issues related to digestion.
7. Indian vegetable for summer – Ash Gourd
As the major constitute of this particular vegetable is water, which is as high as ninety six percent, Ash Gourd helps in cooling the body and helps in maintaining health. It can also provide protection against the heat stroke. This vegetable is known for being loaded with Vitamins like – Vitamin B1 (thiamine) and a good source of vitamin B3 (niacin). The presence of high potassium content is the reason that this vegetable extremely good for maintaining blood pressure. It is also known to be useful in curing various respiratory conditions like asthma, blood related diseases and kidney stones, which is a kind of urinary disease.
8. Indian vegetable for summer - Cucumber
Cucumber is majorly made of water which is as high as ninety six percent. As the water content is very high, cucumber helps in keeping the body hydrated and regulates the temperature of the body. The presence of potassium, magnesium and fibre in Cucumber can be very effective of regulating the blood pressure. The high water content in this vegetable helps in removing all the toxic substances from the stomach and digestive system and hence helps indigestion. Regular consumption of this particular vegetable is highly recommended by various doctors as it can successfully dissolve stones that are formed in the bladder or kidney..
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domain: health


text:
DNA Evidence Used to Exonerate Pro Bono Client
November 3, 2016
Cleary Gottlieb Steen & Hamilton LLP has won a significant victory on behalf of pro bono client Clifford Jones.
At a hearing today in New York Supreme Court, Justice Edwina Richardson-Mendelson dismissed the indictment of Mr. Jones for charges of murder, rape, and robbery, upon the recommendation of the Manhattan District Attorney’s Office. With Justice Richardson-Mendelson’s dismissal, Mr. Jones has been formally exonerated for crimes for which he was convicted and served nearly 30 years in prison. This is believed to be the first time the Manhattan DA’s Office’s Conviction Integrity Unit has exonerated an individual convicted of murder, and the first time that the CIU has exonerated an individual based on DNA evidence. The Conviction Integrity Unit was created in March 2010 by District Attorney Cyrus Vance Jr. to address claims of actual innocence and prevent wrongful convictions from occurring.
In 1981, Mr. Jones was convicted of a murder, rape, and robbery he did not commit. The conviction was based solely upon the testimony of a single eyewitness, who was impaired by heroin at the time she identified Mr. Jones in a photo array nearly four months after the crimes were committed, and a lineup nearly five months after the crimes were committed. There was no physical evidence presented at trial that pointed to Mr. Jones as the perpetrator of the crimes. Mr. Jones’ defense at trial was centered on the misidentification by the impaired witness. Nonetheless, Mr. Jones was convicted. Mr. Jones has always maintained his innocence.
Cleary Gottlieb became involved in Mr. Jones’ case in 2008 and moved for an order for DNA testing of any physical evidence that had not been destroyed. As a result of the motion, hairs from the perpetrator’s hat and fingernail scrapings from the homicide victim were located and tested. A mitochondrial DNA expert determined that the hairs gathered from the perpetrator’s hat matched a common African-origin profile and excluded Mr. Jones as the contributor of the profile. In addition, testing of one of the fingernail scrapings identified foreign DNA that did not match Mr. Jones. Based on this DNA evidence, Cleary Gottlieb lawyers moved to vacate Mr. Jones’ convictions.
In December 2014, the New York Court of Appeals handed down a landmark ruling in the case, unanimously reversing the Appellate Division and Supreme Court’s earlier summary denials of Mr. Jones’ motion to vacate and ruling that he was entitled to a hearing before the Supreme Court on his motion. The decision overturned longstanding precedent in granting the state’s highest court the power to review cases in which new evidence has been presented.
After the momentous Court of Appeals ruling, Cleary Gottlieb’s mitochondrial DNA expert tested the remaining, usable hair samples. Those samples with reportable results matched the same common African-origin profile as the previous test, similarly excluding Mr. Jones. After the conclusion of testing in September 2015, the Manhattan DA’s Conviction Integrity Unit began reviewing the case. Among other steps to convince the CIU to vacate the convictions, Cleary Gottlieb submitted letters explaining the science and applicable law as well as letters attesting to Mr. Jones’ character. In September 2016, Justice Richardson-Mendelson granted Cleary Gottlieb’s motion to vacate Mr. Jones’ conviction, with consent by the Manhattan DA’s Office.


text:
Lou Jiwei, former Chairman, China Investment Corporation
(June 10, 2013) -- China Investment Corp's return on overseas investments hit 11% in 2012, boosting the total fund size to $500 billion, President Gao Xiqing told Chinese newswires.
According to the Xinhua News Agency, the higher return on overseas investments was in part due to its diversified investment portfolio.
"The investment return in the past five years has surpassed previous expectations a little bit, but not that much," Gao said.
Created in 2007, the sovereign wealth fund was tasked to earn higher returns from riskier investments using part of China's foreign exchange reserves, which at $3.44 trillion are the world's largest.
In 2011, the CIC suffered a 4.3% loss on its international portfolio, partly due to weakness in energy and resource stocks as the European debt crisis and US credit rating downgrades rocked markets, according to a report by Reuters.
The fund received $30 billion in new funding in 2011 from the State Administration of Foreign Exchange, the country's top foreign exchange regulator.
A boost to the coffers is good news for the CIC, but it arrives at a challenging time for the sovereign wealth fund - the CIC is still seeking a chairman after Lou Jiwei left to become China's finance minister.
Related News: Why Does Nobody Want China's Top SWF Job? and Power 100: Lou Jiwei


text:
Theodosius Keene was an architect active in the late-18th century, particularly between 1770 and 1777. He was born around 1754 the son of Henry Keene.
Theodosius was born around 1754 as the son of notable English architect Henry Keene, famous for his Gothic Revival and Neoclassical buildings.
He designed Racton Monument around 1770, a red brick turreted folly in West Sussex, possibly built as a summerhouse for the nearby Stansted Estate. Racton Monument stands to this day, albeit a ruin. In 1777 he designed the Maidenhead Guildhall, a replacement for the original medieval building which was constructed around 1430. It consisted of a council chamber, assembly room, a corn exchange, a lockup and also held a beer house called the ‘Fighting Cocks Inn’. The guildhall was demolished in February 1963 to make way for the Town Hall. It is also believed that in 1794 he completed Radcliffe Observatory, under the direction of James Wyatt, since his father died before finishing the building.

domain: history


text:
If there was a court case on whether society should embrace artificial intelligence (AI) or reject it, there would likely be a hung jury.
No-one, it seems, can decide whether the benefits – such as automating written tasks, and sifting through vast amounts of information in seconds – outweigh the problems of biased data, and a lack of accuracy and accountability.
For the legal profession itself, AI represents both a threat and an opportunity. It could lead to a « savage reduction » in jobs for humans, according to a 2021 report from the UK’s Law Society.
And a study this year from the universities of Pennsylvania, New York and Princeton estimated that the legal sector was the industry most likely to be impacted by AI.
At the same time, AI can play a hugely valuable role in researching and putting cases together. Although there is precedent for things going horribly wrong.
New York lawyer Steven Schwartz found himself facing his own court hearing this year, when he used popular AI system ChatGPT to research precedents for a case involving a man suing an airline over personal injury. Six of the seven cases he used had been completely made up by the AI.
« I don’t think that it is a technology story, it’s a lawyer story, » he says. « You’ve got to get through the lack of professionalism [by Mr Schwartz], and the lack of ethics, before you get to the fact that the tool was something he shouldn’t have been using. »