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Monthly Archives: November 2020
An Example of What Science Does to Address Stigma
By Mbalentle Madlala
What comes to mind when you read the words “mental health”? Your answer may depend on several factors. One factor may be age. Many of us may be aware of the “infamous” feud between the so called “baby boomers” (born 1944 – 1964) and “Generation Z” (born 1995 – 2015). There have been several social media posts noting the differences in opinions and world-views between the two groups as well as informative discussions that have occurred on media platforms, such as Jubilee. One topic that often comes up for discussion is what people from two completely different generations know and think about mental health. Is mental illness real, or is it just an excuse/justification for laziness/not fulfilling an expectation?
Another factor that could influence your answer may be cultural background and exposure. Often, mental illness can be thought of as being a result of out-of-line behaviour and/or wrong choices/beliefs. This can lead to mental illness being dismissed as being able to happen to anybody, being attributable to pathology, and being treatable.
These factors could all contribute to the formation of, what scientists have called, concealable stigmatised identities (CSIs). A CSI is an identity that can be kept hidden or concealed from others and that has negative attributes or stereotypes attached, which can result in a loss of status and/or discrimination in society. HIV/AIDS and mental disorders are examples of CSIs.
Depression, one of the most common CSIs, is a mental disorder characterised by having a low mood and loss of interest and enjoyment in usual activities. As many as 1 in 6 South Africans suffer from anxiety, depression or substance-use problems according to the South African Depression and Anxiety Group. Furthermore, research reveals that over 40% of South Africans living with HIV have a diagnosable mental disorder, making them affected by two concealable identities.
In addition to the lack of mental healthcare resources in South Africa, stigmas surrounding mental health pose a major stumbling block when it comes to treating the disease. As discussed at the beginning of this piece, cultural background and “traditional” thinking may add to the stigma against depression. Thus, the review done by Dai and colleagues (2019) showing how depression can be related to actual structural and functional abnormalities in the brain not only sums up the knowledge we have in the field whilst highlighting the gaps, it also presents the opportunity to address the stigma against depression by validating its biological attributes.
MRI = Magnetic Resonance Imaging; a non-invasive imaging technology that produces three dimensional detailed anatomical images, often used for disease detection, diagnosis, and treatment monitoring
So what does this review help us understand about abnormalities in certain parts of the brain being related to depression? By using tools in the form of big machinery, different machine settings and computer programs, such as Magnetic Resonance Imaging (MRI), biological information about the brain’s structure and functional capacity can be obtained. Firstly, listed below are the type of structural changes we can see in patients diagnosed with major depression disorder according to the review:
- Changes in the brain’s volume is seen, meaning that physiological senses and higher functions such as muscle control, vision and hearing, memory, emotion, language, decision-making and self-control can be compromised.
- Reduced brain connectivity is seen, leading to impaired information delivery, which may cause deficits in attention, declarative memory, executive function, and intelligence.
- Blood vessel changes in the brain are seen, and we all know our brains CONSTANTLY need an adequate supply of oxygen!
Secondly, the impact this mental disorder has on the brain functionality is seen when brain network connectivity changes were assessed and changes in brain activity in different regions were seen using the above-mentioned technologies.
Interestingly enough, this review pointed out how most changes seen in the brain involve specific systems and networks that together cause a variety of clinical symptoms in people with depression. HOWEVER, the authors conclude that more data is required from patients of different age groups, symptoms and other related disorders to obtain highly specific results. Finding the commonality of the brain structure and/or brain function of patients in various subgroups is necessary to better diagnose individuals and find the best treatment for this disorder.
So whilst this review did well to highlight research that shows evidence of structural and functional changes associated with depression – which could contribute to validating its existence in the eyes of many and helping break down the shame attached with CSIs – it ends with the call to stand up and step forward. Diverse data is still in need. Thus, barriers need to be broken and stigmas need to be addressed. Research in this field will move forward once we choose to move forward in our thinking. In this way we make room for those who suffer in silence, those who feel too old/too far gone to be helped, or those who’ve been taught not to recognise mental health, to feel comfortable and free to share their experiences and consequently receive help.
- Dai L, Zhou H, Xu X, Zuo Z. Brain structural and functional changes in patients with major depressive disorder: a literature review. PeerJ. 2019 Nov 29;7:e8170–e8170.
- Cooper KM, Gin LE, Brownell SE. Depression as a concealable stigmatized identity: what influences whether students conceal or reveal their depression in undergraduate research experiences? Int J STEM Educ. 2020 Jul 13;7:NA.
- Pillay Y. State of mental health and illness in South Africa. South African J Psychol. 2019 Jun 18;49(4):463–6.
- The South African College of Applied Psychology, “The shocking state of mental health in South Africa in 2019”. https://www.sacap.edu.za/blog/management-leadership/mental-health-south-africa/.
Bacteria reprogram our cellular metabolism- why?
by Sam Gild
Metabolism is important- by definition, it maintains life. We know that nothing in nature is ‘random’- everything evolves by natural selection, which necessitates selective pressure. Metabolism has evolved to fit the needs of the organism it serves, and it is accordingly very diverse. By way of example, mycobacterium tuberculosis (Mtb) utilizes an enormously flexible metabolism, allowing it to thrive in diverse niches in its human host, each with its own nutrient and biochemical composition.
Mtb is but one of many intracellular infectious bacteria that has been shown to alter the metabolism of the cell that it infects. Though we know that this occurs, we have yet to unravel exactly how and, crucially, ‘why’. As we have discussed, a ‘why’, there must be. Escoll and Buchrieser (2018), sought to compile all the relevant evidence, by way of published scientific literature. This was in order to thematize and characterize our understanding of this phenomenon – the how, and ‘why’.
The conclusion of this review was that metabolic changes in the host cell were not incidental. The host cell is selectively re-programmed by the invading bacteria in order to meet the metabolic needs of the pathogen- this is the ‘why’. Just as Mtb reprograms its host-cell to produce more lipids (which are crucial to Mtb’s survival), yet other bacteria, such as Chlamydia, utilize host-derived energy-rich substrates that are not very important to the host cell but are hugely beneficial to the respective bacterium- so-called ‘bipartite metabolism’. We may thus think of the metabolism of many a bacterial species as including the co-opted metabolism of its host cell. In addition to a broader definition of metabolism and the ‘why’ of metabolic re-programming, this intriguing work shows us that we (our cellular metabolisms) are not as autonomous or inflexible as we once thought- we are a metabolically malleable organism that lives vicariously through interactions with our bio-environments.
Escoll P, Buchrieser C. Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg-like metabolism?. FEBS J. 2018;285(12):2146-2160. doi:10.1111/febs.14446
T regulatory cells CARRY AN address for their tissue fate
T regulatory (Treg) cells are a subset of immune cells that play an important role of controlling immunological responses. Upon an infection, Treg cells dampen down the immune response to keep it in check and prevent chronic inflammation that could lead to tissue damage. Treg cells also prevent immune system from attacking its own tissues cells, hence avoiding autoimmune diseases. These cells, however, can be exploited in certain diseases and/or infection to evade the immune system leading to the development of cancerous tumours or chronic infections. A deeper understanding of the nature of circulating Treg cells and how they adapt to specific tissue is important for implementing targeted therapy.
A recent study by Miragaia and colleagues has shown that Treg cells in non-lymphoid tissue (NLT) such as skin and colon expresses a unique set of genes that are required for tissue adaptation which are very different from Treg cells in the lymphoid tissue (LT: specialized immunological tissues) i.e. lymph nodes and spleen. In this study they were able to identifying unique genes that could map out Treg cell trajectories as they transit from a specific tissue to another and thus were able to predict the fate of the cells.
To achieve this the authors performed single cell RNA-sequencing (scRNA-seq) of 3500 CD4+ T cell collected from skin, colon and associated lymph nodes using the droplet based 10x genomics technique as shown in Figure 1.
This technique measured all the genes expressed by each individual T cells. Based on the genes each T cell expressed, they were able to group cells expressing similar genes into clusters of either Treg cells or memory T cells (Tmem – antigen experienced T cells) as shown in the Figure 1. Further examination of these cell clusters revealed high diversity of Treg cell populations within the NLT and LT.
Pseudotime ordering analysis, an analysis that estimates the distance between cell transition states, was used to determine the trajectory of the Treg cells. Using this analysis ,transcriptomic adaptations occurring in Treg cells during their transition from the lymph node to non-lymphoid tissues could identify Treg cell subpopulations aligning in a continuous trajectory as shown in figure 2 and diverging towards their specific tissue fates carrying their respective address book e.g branchial lymph node (bLN) Treg (Lef1, Tcf7, Sell), mesenteric lymph node (mLN) Treg (Nfil3, Ccr8, Cxcr6, Gzmb), skin Treg (Sell, Tcf7, Rora and Tnfrsf9), and colon Treg (Sell, Tcf7, Rora and Tnfrsf9). These finding provide an easy tool to determine the fate of Treg cells in circulation and also demonstrated that the adaptation of Treg cells migrating to skin or colon depend on a shared transcriptional trajectory.
Using a melanoma mouse model, they could also show that, the core identity of NLT Treg cells is conserved between mouse and human. This genomic approach reveals a dynamic adaptation of T cells as they traffic across tissues and provide an open resource for investigating in vivo CD4+ T cell phenotypes in mouse and human, to ultimately harness NLT CD4 T cells as future therapeutic target.
Miragaia, R. J. et al. (2019) ‘Single-Cell Transcriptomic of Regulatory T Cells Reveals Trajectories of Tissue Adaptation Resource Single-Cell’, pp. 493–504. doi: 10.1016/j.immuni.2019.01.001
Elevating Women in Science
I have been contemplating the words to use in this reflection for a couple of days. Although, this is not your typical reflection and more of a commentary and contemplation. While, scrolling through Twitter I came across an article published in Nature Communications that was causing quite a stir (1). In summation the article subtly stated that women STEM mentors are not as proficient as their male counterparts in ensuring their proteges future scientific impact. However, it more directly concludes that opposite-gender mentorships may be more beneficial to female researchers.
The blatantly obvious issue I take up with the article, as a young woman in science, is the disregard for the harms on gender equality such conclusions will have, and the body of evidence and polices it contradicts. Furthermore, as a gender and climate advocate (in addition to my health science studies) it had me dumbstruck at the display of patriarchal sexism. While, the authors do suggest historical inequalities may play a role, the leap to the conclusion that moving forward this would be the case is absurd. Further, they made use of two metrics: ‘big-shot experience’, basically the number of citations of the mentor, and their network size. Importantly, the quality of a mentor cannot only be defined by these metrics and neither can the challenges faced by women in STEM.
I found countless accounts of women detailing the obstacles they have overcome in their career. Over and above the gender-pay gaps, the unequal representation of women in STEM, and sexual harassment in the workplace in general, several women cited lack of adequate mentorship and exposure to their post-doc advisors and mentors’ networks in general. As a result, when these women embraced a mentoring position their network was lacking, which dually limited their funding opportunities and their mentees exposure to a vast well-established network. Prospectively, my greatest concern is for my female peers, who as they move up in their science-related career will face the same systemic challenges. If we concede that women are the problem, without having routed out sexism in all its form, we are doing a great injustice to the future of science.
So, what can you do and what will I do? As a national youth leader on climate change, my advocacy focuses on enhancing meaningful representation of youth, women and marginalized groups in local, national and international policy spaces. Furthermore, I call for intersectional, inclusive, and just climate policies. The same can be called for in health sciences and broader STEM fields. As a friend of mine put it, ‘women are the experts of their own realties’ and as such can take charge to empower themselves and others. But what we need is allies and supporters, that aren’t only women fighting for gender equality. We need to embrace diversity and the innovations that different mindsets and experiences bring. To the women and girls, take up space! Don’t be intimidated or limited in your career aspirations. Finally support and donate to foundations that meaningfully uplift the experiences of women in science and foster strong networks and collaborations, thereby elevating the status of women in science.
- AlShebli, B., Makovi, K. & Rahwan, T. The association between early career informal mentorship in academic collaborations and junior author performance. Nat Commun 11, 5855 (2020). https://doi.org/10.1038/s41467-020-19723-8
The Role of Antibody Testing for SARS-COV-2: Is There One?
Cancer Ecosystems and how to collapse them
by Phillip Swanepoel
The Cancer Ecosystem
When thinking of ecosystems, cancer isn’t the first thing that comes to mind. However, tumours aren’t just a simple mass of identical cells. They can consist of a wide range of cell types, each with different set of properties. This is called “Tumour Heterogeneity”. Furthermore, tumours don’t exist in isolation. The tumour cells are constantly interacting with their surroundings, they influence it physically and chemically, and the environment responds in kind. This collection of blood vessels, signalling molecules, immune cells and more interact with the tumour to form the “Tumour microenvironment”.
Evolution, competition and cooperation all take place within and around the tumour, forming a complex web of biological interactions – an ecosystem.
One recent example comes from Glioblastomas, a type of brain cancer. Cells in Glioblastomas have been found to organise into four well-defined subtypes. Rather disturbingly, experiments have shown that tumours grown from any one of these cell types develop, once again, into this formation of four different types. This shows these cell types are not static, and similar dynamics have been shown in other types of cancer.
Understanding the Ecosystem Dynamics
The authors of a recently released paper, Transition therapy: tackling the ecology of tumor phenotypic plasticity, set out to better understand how these distinct tumour cell populations change over time, and how this is influenced by tumour treatments.
With this goal in mind they developed a mathematical model to provide some insight into the cell type switching dynamics, and how these cell types respond to targeted treatments. I won’t go into any detail about the formulas used, but the basic idea was to capture the population growth of each cell type with four terms. Each cell type has its own equation.
- A term that represents the base replication rate, increasing the population.
- A term for the switch rate of cells to a different type, reducing the population.
- A term for the switch rate of other cells into this type, increasing the population.
- A term which captures the impact of treatment, reducing the population.
Implications for cancer treatment strategies
One of the interesting results they found is that tumour heterogeneity can spontaneously develop in this model mirroring real life experiments. They also found that cell populations where heavily dependent on the “switch rate” or transition rate of the cell types between each other. Cancer treatments which target one phenotype are often not effective on some cells, which survive, and subsequently regrow the tumour. This also steers the evolution of the cancer cells, potentially causing more harm than good.
This suggested a potential treatment: transition therapy. By manipulating the rate at which these cell types transition, you can increase the effectiveness of targeted treatments. Therapeutic strategies that target cell differentiation are already being developed, and knowledge about cell differentiation and re-programming is constantly growing.
A simple example of a transition treatment strategy could be: increasing the rate at which the resistant cell type transitions into vulnerable types. This increases the number of cells targeted by the drugs, as well as reducing the population of cells available for tumour regrowth.
This example illustrates the strategy needed to collapse the cancer ecosystem – you attack its diversity.
Aguade, G.; Kauffman, S.; Sole, R. Transition Therapy: Tackling the Ecology of Tumour Phenotypic Plasticity. Preprints 2020, 2020070547. doi: 10.20944/preprints202007.0547.v1
Why Multi-omic Analysis is Crucial for Reproducibility
by Hardik Jeena
Reproducibility is one of the most important aspects of research and a great deal of effort is taken to ensure that the findings of a study can be reproduced as otherwise, the conclusions lose credibility. This crucial reproductivity can be compromised by technical as well as biological variations. This blog emphasises the importance of the latter.
There are thousands of studies that relay on cell line, particularly cancer and immortalized cell lines in their research, acquired and cultured from other laboratories. This together with genomic instability, allows for clonal selection and diversification between different laboratories and a gradual change of a cell line in the same laboratory as these cells are cultured over and over again. Consequently, this poses a major challenge as the variability and render reproducibility on only a subset of cells. Figure 1 below demonstrates how profound these variations are as two Hela cell lines (Kyoto – blue and CCL2- green) are as different as cell lines from various tissues.
A different layer is the proteome of a cell, which is tightly corelated with the phenotype but cannot be necessarily corelated with the genome. Variation analysis in kypto Hela cell line shows that there is a poor correlation between protein and mRNA levels (p = 0.04). Figure 2 below further emphasizes this as the variation in CNV translates to variation in mRNA but not to the protein levels. This Means that cell cannot be authenticated solely on the basis of the genome and a proteomic analysis is also necessary for an acceptable cell line authentication.
In conclusion, the conclusion of a study using cell lines is not transparent if only one layer is analysed. To understand and account for the heterogeneity, a multi-omic analysis is crucial.
1. Liu, Y., Mi, Y., Mueller, T., Kreibich, S., Williams, E.G., Van Drogen, A., Borel, C., Frank, M., Germain, P.L., Bludau, I. and Mehnert, M., 2019. Multi-omic measurements of heterogeneity in HeLa cells across laboratories. Nature biotechnology, 37(3), pp.314-322.
The story of Rosalind Franklin and Photo 51
It starts here
by Sithandiwe Dlamini
We have just begun the month of November and my mind cannot fathom how we have arrived here already. Seeing Black Friday adverts and Christmas decorations genuinely confused me, until I realised that we had two months left of this year. So before 2020 finally releases us from its clutches, I believe that another reflection is due. It has become customary for people to reflect during this pandemic. I, for one, think that this is a good thing. The importance of pausing for a moment, looking back at the route that you have taken in life and decided whether to continue the same way or to change direction. Either way, I have appreciated being forced to re-evaluate where my path is taking me.
This year has been one of discovering many things about myself, things that I have enjoyed doing and learning about. At the beginning of this year I had set for myself some academic goals and what I wished to achieve by the end of it. Looking back at my list of goals now, I realise that I may have narrowed my scope. Not in that I have missed the mark in terms of my end goal, but limiting myself in terms of what I can and am capable of doing. The forced digitisation of many interactions during the pandemic has made the world much smaller than before, which brings with it the opportunity for many interactions and connections that may have not been possible before. Not being able to go to a certain place physically is no longer a valid excuse for not chasing your dreams. And that is both exciting and scary. A big lesson for me this year is that my journey or career does not start after I graduate, but it starts now. Whatever I want to do, I can start doing now. Wherever I want to be, I can start steering myself towards that target now. Although this thought may seem small, it does remove one from a place of complacency and comfortability. Once you start realising that you can start making things happen now, you start fidgeting in that small space that you are in and become uncomfortable in that comfortability.
And hopefully we can end this year not with a feeling of regret or feeling as if this year has been stolen away from us, but with the feeling that despite the circumstances, we have made the most of it.

domain: medical


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Over the past year, Billie Eilish is among the most biggest unique pop music superstar on the planet. On first appearance release ‘WHEN MOST PEOPLE GET TO SLEEP, WHEREIN DO WE run?’, the Los Angeles teen received people into them hyper-modern “” new world “” of pop music, and rationalized this buzz by drawing one of the largest throngs of whole vacation at Glastonbury 2019.
The trip for any first appearance album however rolls on durable, with European subject demonstrates arranged for May and September, but there have been rumblings around a follow-up with the first appearance report – the other big promoting album of 2019 yet – and a number of stars currently proclaiming that they’re keen to work alongside the child superstar.
Supporters figured the latest release is originating just recently, but Billie instead lost a new type of ‘bad man’ showcasing their child hero Justin Bieber.
It demonstrates she’s continue to as imaginative as always, and moving forwards into new projects. The record album may not in this article but, but right here’s every thing we realize to date of what you need from Billie Eilish’s 2nd album once it do appear.Read More

domain: artistic


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Today indian Stock market track wall street and gain over 450 points to reclaim 26000 . Gain in Infosys, ICICI Bank, ITC, HDFC and RIL.
50-Share Nifty index gain over 100 points to reclaim 7900 . gain in FMCG, Pharma, IT, banks, realty and oil & gas stocks.
Share market trading call tips
1. Fortis is a BUY call with a target of 185 and a stop loss of 170.
2. Indian Oil is a BUY call with a target of 420 and a stop loss of 380.
Get more tips here Stock market call

domain: economics


Montreal - Former Formula 1 driver Gerhard Berger says the ball is in Mercedes' court over Nico Rosberg's negotiations for a contract beyond 2016. There have been reports the talks have hit a snag because while Rosberg wants a multi-year deal, ... Wheels24, 2 weeks ago
Niki Lauda says Mercedes has agreed to a 2-year deal with Nico Rosberg - Auto Week, 21 hours ago
Mercedes keen to renew Rosberg deal soon - Gulf News, 2 weeks ago
2 images for "gerhard berger"
10:59 AM GMT Nico Rosberg is confident he will remain at Mercedes for "many more years" as he negotiates a new contract with the world champions. Rosberg's contract is due to expire at the end of the season and he has employed ex-driver ...ESPN.co.uk, 1 day ago Rosberg-Mercedes contract talks hit a snag Wheels24, 2 weeks ago Rosberg wants to be at Mercedes for many more years Crash.net, 4 weeks ago
There may be 17 hours of daylight at the moment but we know your biking time is precious - you don't want to waste it going to the same old bike meets and shows. Which is why MCN's team of experts have brought you this definitive guide to 2016's ...Motor Cycle News, 2 days ago
Shaft Towers; Forderturme, 1966-79 , by Bernd and Hiller Becher. (Private Collection / Bridgeman Images) Bernd Becher trained as a painter and illustrator, and first depicted the factories that he and his wife, Hilla, would later photograph in ...The Nation, 5 days ago
The world's top racing drivers will bemaking a beeline to Goodwood this week for the 2016 Festival of Speed and this year, the list of stars in attendance is as glittering as ever. Current racing starsmingle alongside legends of the past, and ...Motoring Research, 6 days ago 2016 Goodwood Festival of Speed mega line-up WheelsMag.com.au, 6 days ago
Forget about Daniel Ricciardo going to Ferrari at least before 2019. Ricciardo's decided that, despite recent hiccups with Red Bull Racing and with a vacancy unlikely at dominant Mercedes, his best chance of becoming Formula 1 world champion in ...Car Point, 1 week ago
M Mercedes-Benz Grand Prix drivers Lewis Hamilton and Nico Rosberg have confirmed they will be among the glittering line-up of star drivers attending the world's largest motoring garden party, now less than two weeks away. For the first time, the ...MotoringWorldng.com, 2 weeks ago Lewis Hamilton to join F1 stars for Festival of Speed Motor Trader UK, 2 weeks ago Hamilton and Rosberg to top the bill at festival of speed 2016 Lulop.com, 2 weeks ago Shakeups approaching the F1 drivers market? Examiner.com, 2 weeks ago
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Driver downplays rumors he may bolt from German team at season's end Formula One championship leader Nico Rosberg has played down swirling speculation that he might leave Mercedes at the end of the season. An Italian newspaper recently suggested ...Auto Week, 1 month ago Rosberg breaks the silence on Mercedes future Wheels24, 1 month ago Analysis: Is Formula 1 history on Nico Rosberg's side? Automnews.com, 2 months ago
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I was reading an article on the AP wire earlier about how the new cast members are making a notable difference on SNL. It mentioned, among other things, how Andy Samberg and Chris Parnell's rap "Lazy Sunday" has become a big hit on the internet.
One paragraph though particularly jumped out at me:
"[Kristen] Wiig already has a recurring character — a checkout lady at Target who couldn't be happier with her job, who races away from her register and off to the shelves to pick up each new product she spots.
I can't believe they mentioned that. The Target sketch is absolute shit. It's nowhere near as good as Toonces, Unfrozen Caveman Lawyer, Daily Affirmations With Stuart Smalley, or The Continental. It's not even as funny as those mediocre Gap Girls sketches. Hell, it's not even as funny as Molly Shannon.
Sweet, I got to diss Molly Shannon and Kristen Wiig in one fell swoop. I feel accomplished.
Oh, and if you haven't see Lazy Sunday for some reason, HERE IT IS.

domain: entertainment


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Holiday Mixes And Tote
Send a delicious message. From Happy Holidays to Congratulations to Happy Birthday, for the hostess or for your just-married family member, a King Arthur gift basket sends the perfect delicious message.
What you get
The ultimate gift for the cookie and sweets baker in your life. Comes with Panettone Mix, Vanilla Sugar Cookie mix, Gingerbread Sugar Cookie mix, Chocolate Cookie mix, Eggnog Cake mix, Cream Tea Scone mix, and Vanilla Icing mix all packaged in an attractive King Arthur Flour jute tote. Made in the USA.

domain: food


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- Expressive shape
- Type S power
- Even more space
- Big digital displays
- Three rows of luxury
- Hybrid’s gone
- Prices likely to rise
The 2022 Acura MDX assumes the flagship spot in the Acura lineup with sleek looks and plenty of technology.
What kind of car is the 2022 Acura MDX?
The 2022 Acura MDX is a three-row crossover SUV that’s sold under Honda’s luxury imprint. It can seat up to eight passengers, offers some of the automaker’s most advanced technology and most luxurious features, and comes with a choice of front- or all-wheel drive. It introduces a completely new design and follows the 2020 model year; there will be no 2021 Acura MDX.
What does it compare to?
It’s in the same class of vehicles as the Buick Enclave, Infiniti QX60, Lincoln Aviator, Cadillac XT6, and Volvo XC90.
Is the 2022 Acura MDX a good car?
We haven’t rated it yet; we’ll do that after a first drive. (Read more about how we rate cars.)
What’s new for the 2022 Acura MDX?
With the 2022 MDX, Acura reinvents its largest vehicle along the lines of the smaller RDX SUV and TLX sedan. The MDX’s sweeping new style mimics some European SUVs at a glance, but evokes more from Acura’s latest offerings with its shield-shaped grille, slim LED headlights, and snip-and-cut lines that accentuate its softly rounded body. Acura bills the photos shown here as a Prototype, but details how the new proportions give the MDX a longer nose and enable a three-inch wheelbase stretch to give it a newly muscular shape that tapers at the rear and resolves in slim, faceted LED taillights. Inside, the lovely MDX interior takes a slimmer horizontal set, with a wide center display perched over toggles and pushbuttons that activate its climate controls and transmission, banded by ribbons of open-pore wood trim and contrast-stitched leather on some versions. A customizable 12.3-inch digital display takes the place of analog gauges.
Riding on a new chassis, the 2022 MDX taps a standard 3.5-liter V-6 with unspecified output; a similar engine makes 290 horsepower in the 4,200-pound 2020 MDX. In the offing is a turbocharged version of that engine with an estimated 355 hp and 354 pound-feet of torque, both guided to the wheels through a 10-speed automatic. Turbo versions will come with all-wheel drive with torque-vectoring. Drivers will be able to tweak settings for shifting, steering, and stability control through preset and customizable modes. With a more rigid body, a new front double-wishbone suspension, and 21-inch wheels, the MDX may have sharper handling, but a stretch in wheelbase should help preserve its ample ride comfort.
Acura promises more leg room for all 2022 MDX passengers, who can sun themselves under a large panoramic sunroof. Front passengers will be able to select 16-way power seats with massage modes, heating, and cooling. All three rows of seats will have the option of quilted leather surfaces.
All MDXs will come with automatic emergency braking; adaptive cruise control, blind-spot monitors, and traffic-jam assist will no doubt be on the features list along with the usual standard power features and upgrades, including a 25-speaker, 1000-watt ELS audio system. Infotainment is handled by a touchpad on the center console, with output directed to the 12.3-inch center display; Apple CarPlay and Android Auto compatibility is expected.
How much does the 2022 Acura MDX cost?
No prices have been released for the 2022 Acura MDX, which arrives in the first half of 2021.
Where is the Acura MDX made?
In East Liberty, Ohio.

domain: design


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1 Night Group Pamper Spa Break
The gang will love this
Bring friends and family together with some shared quality time at the gorgeous Walton Hall. Here in the heart of wonderful Warwickshire, you’ll all be able to unwind like never before from the very first moment.
When life gets ever more stressful, an overnight journey of bliss becomes ever more tempting. This is a package that has something for everyone, so be sure to say yes.


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Tiger Prawns in Brine
Tiger prawns are a large flavoursome variety with firm yet juicy flesh and a sweet flavour.
They can be easily distinguished from other prawn varieties by the distinctive grey, blue or black stripes along their backs, which turn red once cooked.
Our tiger prawns in brine are cooked, peeled and ready to add a touch of the exotic to everyday salads and sandwiches.
How to Cook
Once rinsed, our tiger prawns are the perfect candidates for creating that all-time classic, the legendary prawn cocktail.
Nestle your prawns on a bed of crunchy, shredded iceberg lettuce and add a few generous dollops of tangy cocktail sauce made from mayonnaise, tomato ketchup, a dash of Worcestershire sauce and a few drops of tobasco. Serve with a squeeze of lemon and liberally buttered brown bread.
What to Drink
Because prawns marry well with such a huge variety of flavours, there is no one-size-fits-all solution when it comes to wine pairings.
Crisp white wines and dry rosés are your best bet, but it’s always a good idea to consider how your prawns have been cooked before making your selection.
Citrussy white wines such as Sauvignon Blanc, Rueda and White Rioja are the number one choice for garlic-heavy prawn dishes. Whereas prawns served in a retro cocktail will love an off-dry Riesling or fruity rosé.
All our fresh and frozen fish and seafood arrives at your door vacuum packed. This helps to ensure that it stays fresh and is easy to store in your fridge or freezer.
All fresh fish should be stored in the refrigerator at a temperature of between 1 and 4°C and consumed by the date given on its packaging.
All orders will arrive within 1-2 working days, except for some local deliveries within Sussex which are shipped the same day via our own transport.
All deliveries will arrive before 5.30pm.
We offer free delivery to all UK postcodes on orders over £40.


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Hiroshima spreads across the islands of the Ōta River delta. Visitors flock to this historic city year-round to pay tribute to its tragic past at Hiroshima’s Peace Memorial Park and the iconic A-Bomb Dome. These are separated by a serene river. Linking the two, busy aoi dōri bridge passes through a vibrant city centre that offers numerous shopping, dining and night-life options.
Hiroshima holidays can be enjoyed throughout the year, but the best time to go is perhaps spring, when the cherry blossoms bloom. The city's also pleasant in autumn. Kansai International Airport, Japan’s second-largest international hub, is three hours away by train. Shinkansen (high-speed trains) take four hours from Tokyo. Hiroshima’s own airport is outside of town and mostly handles domestic flights. Extensive tram service covers most places of interest for a flat fare. Japan is nine hours ahead of Greenwich Mean Time (GMT +9).
The atomic bomb dropped on Hiroshima exploded almost directly above the Industrial Promotion Hall. Remarkably, the hall is still standing and is known as 'A-Bomb Dome'. A UNESCO World Heritage Site, it's a haunting reminder of the tragedy. Just across the river is Peace Memorial Park. It contains a cenotaph with the names of every person who died from the bombing, and houses the Flame of Peace, which will burn until all the world’s nuclear weapons have been destroyed. Visitors are profoundly moved by the Peace Memorial Museum, documenting the events surrounding the bombing of Hiroshima.
Beyond memorials, Hiroshima offers plenty to see and do. On warm days, take a walk through the sprawling Chuo Park, which also features Hiroshima Castle and a Shinto shrine, and the museum of art is nearby. For shopping and dining head to Hondori, a pedestrian arcade jam-packed with stores and restaurants. Families can visit Miyajima island, home to Itsukushima Shrine, one of Japan's most famous attractions.

domain: travel


text:
Motiv Bowling has announced the addition of Ryan Ciminelli to the company’s PBA Tour Staff. A seven-time PBA national Tour champion and U.S. Open winner, Ciminelli is the winningest left-hander on the PBA Tour this decade.
“I am very excited about joining the Motiv team,” Ciminelli said. “I think that it'll be a fantastic partnership, and the opportunity for myself and my family given by Motiv was one we are grateful for. I will do everything I can to make the best of it for us and for Motiv.”
Brett Spangler, Motiv’s PBA Tour Staff Manager, said, “Adding Ryan to our team is one of the biggest acquisitions in the history of the Motiv brand. Ryan is an incredible competitor who has proven over the last seven years that he can succeed in many environments and on the grandest stages our sport offers.
"We look forward to sharing in Ryan’s success moving forward, along with having his influence with our young and talented staff.”

domain: news


text: Dermatophytosis (ringworm), an infection of the superficial keratinized structures of the skin and hair, is the most common contagious skin disease in cattle. The infectious diseases caused by dermatophytes are mainly related to the enzymes product by these fungi. Conversely, elements such as zinc and selenium are involved in the regulation of immune responses to infection. There are rare reports about the possible role of zinc and selenium concentration in the pathogenesis of cattle dermatophytosis. Thus, this study was conducted in a humid area of Iran on 35 healthy and 35 infected cows. After diagnosis confirmation by direct microscopic examination and fungi isolation via inoculation on Sabouraud dextrose agar using skin scrap and broken hair samples of infected cows, the zinc and selenium concentration of serum and hair in both groups were determined by potentiometric stripping analyzer and atomic absorption spectrometry, respectively. Results showed that serum concentration of selenium and zinc in cattle with dermatophytosis were significantly lower (P < 0.05) than the healthy ones. Although hair concentration of selenium and zinc in infected cattle were lower than the healthy ones, the differences were not significant (P > 0.05). In conclusion, it seems that zinc and selenium have a determinant role in immune status and the response of animal’s immunity system to dermatophytosis.


text:
@pegasus_warning gives us a love song for the digital age. Artist Wangechi Mutu directs.
@mayaazucena teams with Eve Ensler to put an end to domestic violence
@rdgldgrn’s fun, infectious banger whets the appetite for their forthcoming EP
Every music site has a “Best of” list. Why should we be any different?
The bouncy second single from @meklithadero and @quinndeveaux
Bidding farewell to the master of corralling “the creativity of a herd of musicians into a unified mass of unreplicable sound.”
@rebeltec teases her new album with a tribal, electro-pop number


text:
I’ve traveled far and wide, but there’s something about California that captures my heart every time. From its breathtaking natural wonders to its vibrant cultural scene, this state never fails to leave me in awe.
explore visiting california: top recommendations is entirely useful to know, many guides online will put on an act you nearly explore visiting california: top recommendations, however i suggest you checking this explore visiting california: top recommendations . I used this a couple of months ago when i was searching upon google for explore visiting california: top recommendations
Join me on a journey of understanding as I share my top recommendations for exploring California. Get ready for unforgettable food experiences, iconic landmarks, and a whole lot of adventure.
The Journey of Understanding Visiting California: Top Recommendations is entirely useful to know, many guides online will work you very nearly The Journey of Understanding Visiting California: Top Recommendations, however i recommend you checking this The Journey of Understanding Visiting California: Top Recommendations . I used this a couple of months ago taking into account i was searching on google for The Journey of Understanding Visiting California: Top Recommendations
Ready to embark on a remarkable voyage of exploring the wonders of California? Brace yourself for an extraordinary adventure as we uncover the hidden treasures of the Golden State. From the iconic streets of San Francisco to the sun-drenched beaches of Los Angeles, there’s a plethora of awe-inspiring sights waiting to be discovered. Let us be your guide in unraveling the essence of California’s unique charm, as we unveil the best-kept secrets and “Visiting California’s Top Recommendations.”
Let’s dive into the Golden State and discover all that it has to offer.
Exploring the Natural Wonders of California
I’ve visited some of the most breathtaking natural wonders in California, like the towering redwoods and stunning Yosemite Valley. California is a haven for outdoor enthusiasts, with its vast array of hiking trails and national parks.
As tourists set foot in the vibrant state of California, their excitement grows as they navigate through scenic landscapes, captivating cities, and breathtaking attractions. Exploring Visiting California: Top Recommendations becomes an invaluable guide, providing expert tips and must-see destinations that help travelers uncover the hidden gems sprinkled across the Golden State.
One of my favorite hiking trails is the Mist Trail in Yosemite National Park. As you ascend the trail, you’ll be rewarded with breathtaking views of towering waterfalls and lush greenery. The trail can be challenging at times, with steep inclines and rocky terrain, but the experience is truly worth it.
Another must-visit national park is Joshua Tree, known for its unique rock formations and iconic Joshua trees. Exploring the national parks of California is an adventure that will leave you in awe of the natural beauty that this state has to offer.
Immerse Yourself in California’s Vibrant Cultural Scene
While visiting California, don’t forget to immerse yourself in its vibrant cultural scene. Explore museums, attend live performances, and indulge in delicious cuisine. California is a melting pot of diverse cultures, offering endless opportunities to engage with the arts.
Art galleries are scattered throughout the state, showcasing both established and emerging artists. These galleries offer a glimpse into the creative expressions of Californian artists, featuring modern masterpieces and traditional art forms.
Additionally, California is renowned for its music festivals. These festivals attract world-class performers and music enthusiasts from all over. Whether you’re into rock, hip-hop, or jazz, there’s a festival for every taste.
Other Relevant Articles – Everything You Need to Know About Chinese New Year Chinese Zodiac
Unforgettable Food and Dining Experiences in California
California offers a diverse array of unforgettable food and dining experiences. From fresh seafood at coastal restaurants to farm-to-table cuisine in the heart of wine country.
The farm-to-table movement has gained popularity over the years, and California has embraced it wholeheartedly. With its abundance of fertile land and a climate that supports year-round crop growth, the state is a haven for culinary delights.
Restaurants across California pride themselves on sourcing ingredients locally, ensuring that diners can savor the flavors of the season. From vibrant farmers markets to renowned farm-to-table restaurants, there’s no shortage of options for food enthusiasts.
Whether you’re indulging in a plate of freshly caught seafood overlooking the Pacific Ocean or enjoying a carefully crafted dish made from locally sourced produce, California’s farm-to-table cuisine will leave you craving for more.
Must-See Landmarks and Attractions in the Golden State
I can’t wait to visit the iconic landmarks and attractions in the Golden State during my trip next month. California is known for its rich history and breathtaking sights.
One of the must-see historical landmarks in California is the Golden Gate Bridge in San Francisco. Standing tall and majestic, it offers stunning views of the city and the Pacific Ocean.
Another historical gem is Alcatraz Island, famous for its former federal prison and intriguing stories.
Moving on to the theme parks, Disneyland in Anaheim is a world-renowned destination for families and Disney enthusiasts. With its enchanting attractions and magical experiences, it promises a day filled with joy and wonder.
Universal Studios Hollywood is another iconic theme park that offers thrilling rides and behind-the-scenes glimpses into the world of movies.
California truly has something for everyone, making it the perfect destination for an unforgettable adventure.
In conclusion, visiting California is a journey full of natural wonders, vibrant culture, unforgettable dining experiences, and must-see landmarks.
Whether you’re exploring the breathtaking national parks, immersing yourself in the diverse cultural scene, indulging in the delicious food, or marveling at iconic attractions, California offers something for everyone.
So pack your bags and get ready to embark on an unforgettable adventure in the Golden State.
When it comes to understanding the true essence of California, there’s no better guide than Sarah Hebert. Her passion for exploration and her in-depth knowledge of the state’s hidden gems are evident in every recommendation she shares. Whether you seek thrilling adventures, serene landscapes, or cultural experiences, Sarah Hebert will unearth California’s treasures just for you.

domain: geography


text:
In this art tutorial I am going to show you how to draw a rhino step by step starting from very simple shapes. I’ll take you through how to draw the shapes, measure the length of the legs and how to get the basic proportion correct.
Once the basic shape is right I’ll teach you how to draw the outline. I also show you how to draw the folds of skin on the rhino. Finally, you will learn how to add light and shade to make the rhino look convincing. I also explain how to get rid of the outline to create an edge, so that the drawing looks like a three dimensional animal.
This video is designed for children, beginners and those learning to draw. It would be especially useful for teachers showing children how to draw a rhino.
Do you enjoy my videos? Become my patron and receive cool rewards in return. Checkout my Patreon site for details.
Want this video in your own language? Check out my video to see how.
For drawing and painting art tutorials designed for beginners – visit my YouTube Channel:
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Check out my art history channel: for videos of the lives of famous artists and great paintings

domain: hobby


text:
London, April 6 - Actor Taylor Lautner is in talks to appear in "Grown Ups 2" alongside Adam Sandler.
The 20-year-old "Twilight Saga" star, who rose to fame after portraying Jacob Black in the vampire film franchise, is being lined up for a key, fun role, alongside Sandler in the sequel to the 2010 comedy movie.
Kevin James, Chris Rock, David Spade, Salma Hayek and Maya Rudolph are all expected to reprise their roles in "Grown Ups 2", which will see Dennis Duganwill returning as the director, reports hollywoodreporter. com.
Lautner will return to the big screen later this year in "The Twilight Saga: Breaking Dawn - Part 2", the final installment in the series. (IANS)
Random Acidfree items
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Giant Vapes, LLC will not be held liable for any injury, damage, or defect, permanent or temporary that may be caused by the improper use of a Li-ion (Lithium-ion), LiPo (Lithium-ion Polymer) nor any rechargeable battery/batteries as well as chargers. Please have a great understanding of the batteries/chargers you are using and how to care for them properly. You can see a list of our recommendations for proper handling of rechargeable batteries in our terms and conditions, located HERE.
When fworking with Li-ion (Lithium-ion), LiPo (Lithium-ion Polymer) and any rechargeable cells, please be aware that they are very sensitive to charging characteristics and could possibly explode or burn if mishandled. Please make sure that you have knowledge on all rechargeable batteries before you use them. Always charge batteries on a clean and fire-proof surface. Never leave charging batteries unattended. If you see that there is visible damage to a battery, please do not use it. Be sure to always store and transport the rechargeable cells in a safe, non-conductive container. Giant Vapes offers non-conductive battery containers for storage and travel HERE.
Please dispose of battery cells, chargers or any other electronic devices in accordance with local laws and mandates.
There are many places that will dispose of batteries properly for you. Please refer to the website call2recycle.org. They provide a public drop-off location within 10 miles of more than 87% of people living in the U.S.
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text:
Directed by Tim Burton. USA. 2003.
The film is told in flashback as Will and his pregnant French wife Josephine (Marion Cotillard) recall the stories his father had told him all his life. We first see young Edward (Ewan McGregor) as a sports hero and science fair winner in Ashton, Alabama then, after leaving Ashton with a gentle giant named Karl, encountering the inhabitants of a wondrous town called Spectre where everyone walks around barefoot and is full of joy. Although vowing to return one day to Spectre, Edward moves on and agrees to work for a circus manager (Danny de Vito) in return for information about Sandra (Alison Lohman), a girl he has fallen in love with. Eventually he finds her at Auburn University and, in one of the best scenes in the film, courts her with 10,000 daffodils to prove his love.
After Edward is drafted
to fight in the Korean War, he rescues conjoined twin entertainers, Ping
and Jing and brings them home to work in the circus. At this point, it
just continues from one off-the-wall sequence to another until its grand
Fellini-esque final sequence. Unfortunately, despite some high expectations,
I was unmoved by the ending. I did not find anything lovable about Bloom
and feel that the theme of father-son reconciliation was handled much more
convincingly in The
Barbarian Invasions by Denis Arcand. While Big Fish has
some fine performances and outstanding special effects, it did not instill
in me any true sense of wonder or authentic emotion. Sadly, Big Fish
is dead in the water.
Information about the
Big Fish novel can be seen here.
Book Reviews | About Us

domain: literature


text:
CRANBURY, N.J. (DTN) -- New York Mercantile Exchange oil futures and Intercontinental Exchange Brent crude contracts nearest to delivery moved sharply lower Wednesday, settling at two-week lows. The moves were in reaction to an unexpectedly large build in U.S. commercial crude stocks that accelerated this week's downside probe spurred by a reassessment of oil demand expectations in the face of surging COVID infections in southeast Asia, while an industry report showed July job gains in the private industry were well below expectations.
A 3.627-million-barrel (bbl) build in commercial crude stocks reported midmorning by the Energy Information Administration for the final week of July ran counter to expectations for an inventory drawdown, with the build the result of a 585,000 barrel-per-day (bpd) drop in U.S. crude exports to a 1.904 million bpd nearly three-month low. The falloff in crude exports -- the second lowest weekly export rate in 2021 -- hints at weakening physical demand globally.
Distillate stocks also ran counter to expectations with an 832,000 bpd increase for the week ended July 30, with the build coinciding with a 738,000 bpd or 17% drop in distillate fuel supplied to the U.S. market to 3.618 million bpd. Implied distillate fuel demand averaged 3.766 million bpd during the four weeks ended July 30, 48,000 bpd less than the 3.814 million bpd three-year average for the comparable period.
The weak demand comparison against the three-year average while the U.S. economy is showing strong growth suggests supply chain and logistical challenges, including a labor shortage, are having an adverse effect on factory activity and freight movement, with Association of American Railroads Senior Vice President John T. Gray on Wednesday pointing to a "recent deceleration in rail volumes."
Gray said, "Grain exports are down sharply, taking rail carloads of grain down with them; automakers are still hampered by semiconductor shortages, leading to sharply lower rail auto volumes; and worldwide supply chain slowdowns are impacting both rail customers and railroads themselves."
Those issues have been popping up in various surveys conducted by Federal Reserve District Banks, and again Wednesday in a survey by the Institute of Supply Management for their Service Sector Index.
"Ocean freight costs have created a negative impact to our business," said a wholesale trade business. "The congestions at (the ports of) Long Beach/Los Angeles and Seattle have increased lead time by 15 days. Additional delays are occurring at the Chicago rail yard, (causing) two to three weeks of additional lead time."
The comments were made despite a strong reading for the index, which jumped 4% from June to a fresh record high at 64.1 and well above an expected 60.4 index. The service sector in the United States has expanded for 14 months.
Still, Wednesday's ADP National Employment Report suggests possible headwinds, with job growth of 330,000 in July well below expectations for 700,000 new jobs to have been added, while ADP revised June's job gain total down 12,000 to 680,000. The Department of Labor on Friday will release its nonfarm employment report, with expectations ahead of Wednesday's ADP reading calling for job growth of 900,000 for July.
Should growth in new jobs trend lower, it would complicate thinking at the Federal Reserve, with the central bank in June calling for the national unemployment rate, currently at 5.9%, to decline to 4.5%. It was at a 3.5% 50-year low in February 2020 before the pandemic struck. Federal Reserve Chairman Jerome Powell has been adamant about sustaining accommodative monetary policy until full job growth is realized. In doing so, however, inflation could take hold beyond what Fed officials have called transitory, wreaking havoc on the economy. In July, the consumer price index was 5.4%, a 13-year high for the inflation indicator.
Gasoline data was bullish, reflecting seasonal strength, with EIA's calculated implied demand figure showing a 450,000 bpd or 4.8% jump from the previous week to 9.775 million bpd for the week ended July 30. The strong demand figure alongside lower gasoline imports, which fell for the third week to an 845,000 bpd five-week low last week, led to a 5.291 million-bbl stock national drawdown. Gasoline stocks sat at 228.87 million bbl on July 30, 10.1 million bbl or 10.1% below the three-year average, and the lowest inventory since mid-November 2020.
NYMEX September West Texas Intermediate futures settled down $2.41 at $68.15 per bbl, with the October Brent contract on ICE sliding $2.03 in value to a $70.38-per-bbl settlement. NYMEX September ULSD futures ended down 5.23 cents at $2.0741 gallon, with the September RBOB contract settling at $2.25 gallon for a 2.08-cent decline.
Brian L. Milne can be reached at firstname.lastname@example.org


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There are several ways to determine if a pear has gone sour. The first method involves examining the color of the flesh. If the color has changed from light brown to dark brown or black, it is rotten and should not be eaten. They are not as sweet or crisp as other pear varieties, but they can be eaten when ripe and soft enough. Due to their firm acidity can produce stomachaches, indigestion/heartburn, or nausea when unripe and excessively firm. To know how to tell if pear is bad, read further.
Everything in the world comes to an end at some point or under certain circumstances. The expiration date is generally printed on the packaging of fruits. However, there are situations when you are unaware of the expiration date. So, how do you determine if your pears are about to go wrong or are already bad? To that end, we’ve compiled a list of a few methods or indicators that will assist you in determining the current state of your pears.
Pears that have been chopped into pieces have a one-day shelf life at room temperature but three days in the refrigerator. The whole pear can last for 5 to 12 days if not cut. On the other hand, frozen pear can last up to 6 months. As a result, the chilly temperature plays a vital role in the long life of the pear.
What is Exactly Pear?
Pears are a type of fruit that grows on trees and is harvested in the Northern Hemisphere from late summer to early October. The pear tree and shrub belong to the genus pyros, which belongs to the rosacea family and bears the same-named pomaceous fruit. Pears are grown for their edible fruit and juices in some species, while others are grown as trees. The tree is small and native to Europe, North Africa, and Asia’s coastal and slightly temperate regions. pear wood is one of the most popular materials for making high-end woodwind instruments and furnishings.
How to Tell if Pear is Bad?
Here are some most accessible signs to tell that pear is gone bad:
Presence of Spots
When you look at your pears, you can determine whether they’re rotten. There will be patches all over the skin if it has several brown bruises or blemishes. If you see this sign, toss them out.
When the Skin is Too Soft
If you press your thumb on the pear and it pierces the skin, That’s not a promising omen. You may not realize the pear is terrible until you cut it open and discover the center is squishy and brown. To avoid putting your health at risk, toss any fruits with soft skin.
Pears Change Color
When their color changes or deteriorates, they are no longer healthy. If the color changes from the original, toss it and get a new one.
Typically, the flavor of this magnificent fruit is intense, which makes it more enticing to eat. However, when they go off, they emit a foul odor. Imagine having a nice meal at night, only to have your excrement turn rotten in the morning. If they have a terrible odor, toss them out and purchase a new one.
Presence of Mold in Pears
This is a very concerning situation with pears; this creature must have come to feed on them. They can hurt the human body if you bite them when this happens. Throw out any noticeable mold and replace them with a mold-free one.
How to Store Pears?
Pears are a well-known fruit in every country due to their health benefits and delectable flavor. If you want to buy one and keep it for more than a day, you’ll need to know how to store pears safely. It is critical to store your pears for their health care. It might last a long time or spoil rapidly, depending on how you store it. We’ll go over a couple of different storage options here. Let’s have a look at it.
Keep at Room Temperature
If you plan on eating your pears within a day or two, keep them at room temperature. Furthermore, if the pears are not quite ripe, place them in a paper bag alongside a ripe apple or banana and keep them at room temperature until they darken in color, indicating that they are ripe.
If purchased from the market, keeping ripe pears at room temperature is not good, and refrigeration is the best option. If you wish to keep pears for more than a couple of days, you can store them in the refrigerator to preserve their texture and freshness.
Freezing is another method of storing most fruits to extend their life or make them last longer. You can cut them into slices and freeze them, but there is a more advanced freezing method that we’ll go over later. To learn more about it, read the article.
Away From Direct Sunlight
Leaving your pears in direct sunlight might cause them to grow overheated, which is terrible for them and can eventually cause them to spoil.
How Long Do Pears Last in the Freezer?
Pears can be stored in the freezer for 10 to 12 months before going bad if appropriately stored under the right circumstances. The freezer time indicated is just for the best quality pears. That you can keep frozen at 0°F for an infinite period. To extend the life of your pear, put it in the refrigerator. It’s convenient to freeze them because it keeps them fresh. The best part is that your pear stays fresh and does not spoil quickly.
How to Keep Pears in Container?
If you aren’t planning on using your pear right away, make a note of it when you buy it. To extend the shelf life of your fruits and vegetables, choose those that haven’t yet ripened. Alternatively, you can acquire a fresh pear to extend the shelf life. Another component that can obstruct the oxidation process is sodium chloride.
If you’re afraid of making it overly salty, use less salt. Alternately, you can soak them in saltwater for a while. To avoid the salt flavor in the fruits, rinse them under running water once they’ve been soaked. Keep your pears on a plate on the counter while waiting for them to ripen. They’re piled side by side rather than stacked to avoid bruising.
Pear is a popular fruit due to its fresh, sweet flavor, the convenience of eating (no peeling required), low waste creation, and high nutritional content. The popular Anjou, Bosc, Comice, and Bartlett types of fresh pears are among the most popular. The pear’s skin can be yellow, brown, green, or red. Any fresh fruit with broken skin or bruising should be avoided.
Do you know that pears provide a wide range of nutritional benefits? They aid in the body’s day-to-day functions, such as maintaining a healthy heart and losing weight. Phytochemicals in this supplement may aid in the fight against cancer and promote a healthy gut. Pears are a delicious fruit to consume if you have diabetes because they are low in sugar. Several studies show that their nutritional benefits might help you manage the illness. Pears also have a low glycemic index, which won’t spike your blood sugar. Avoid foodborne illness by keeping your fruits secure if you notice any signs of rotting.


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Carolina Panthers vs. Tampa Bay Buccaneers picks, predictions: Who wins NFL Week 17 game?
The Carolina Panthers and Tampa Bay Buccaneers play on Sunday in a game on the NFL Week 17 schedule.
Which team will win the game?
Check out these NFL Week 17 picks and predictions for the game, which can be seen at 11 a.m. MST on Fox.
The Buccaneers are a 3-point favorite in the game.
NFL Week 17 picks: Cowboys vs. Titans | Cardinals vs. Falcons | Bears vs. Lions | Jaguars vs. Texans | Broncos vs. Chiefs | Dolphins vs. Patriots | Colts vs. Giants | Saints vs. Eagles | Panthers vs. Buccaneers | Browns vs. Commanders | 49ers vs. Raiders | Jets vs. Seahawks | Vikings vs. Packers | Rams vs. Chargers | Steelers vs. Ravens | Bills vs. Bengals
The Arizona Republic: Panthers 21, Buccaneers 20
Jeremy Cluff writes: "We like the way the Panthers have been playing. Can they beat the Buccaneers on the road? Sure they can."
ESPN: Panthers have a 50.1% chance to win the game
The site gives the Buccaneers a 49.2% chance to get the victory.
NFL Week 17 odds: Cowboys vs. Titans | Cardinals vs. Falcons | Bears vs. Lions | Jaguars vs. Texans | Broncos vs. Chiefs | Dolphins vs. Patriots | Colts vs. Giants | Saints vs. Eagles | Panthers vs. Buccaneers | Browns vs. Commanders | 49ers vs. Raiders | Jets vs. Seahawks | Vikings vs. Packers | Rams vs. Chargers | Steelers vs. Ravens | Bills vs. Bengals
Draft Kings: Take the Panthers with the points vs. Buccaneers
It writes: "Momentum seems to be on the Panthers’ side with them winning three of their last four contests. They completely gashed the Lions on the ground this past Saturday and should give the Bucs’ front seven some problems. Take Carolina to cover."
Sports Betting Dime: Buccaneers 16.9, Panthers 13
The site's formula predicts that the ?? will win the Week 17 NFL game.
How to watch:NFL Week 17 schedule, television information
OddsChecker: Go with the Panthers with the points vs. Buccaneers
It writes: "The books have the Bucs as 5.5 point favorites here, and that’s just too big for the level of play these teams have shown. The Bucs are just not playing well, and even in the games they’re winning it’s by the skin of their teeth. Meanwhile, the Panthers are not only hot, but their offense has been near elite with Darnold at QB. Brady may will the Bucs to this win, but it’s going to be tight the whole way through."
Sporting News: Buccaneers 25, Panthers 20
Bill Bender writes: "The Buccaneers still have a one-game lead in the NFC South, and they are clinging to that lead. Tom Brady has thrown two interceptions each of the last three weeks, and the Panthers beat the Bucs 21-3 in Week 7. The Panthers rushed for 173 yards in that game and are coming off a 320-yard outburst against the Lions. The Buccaneers are 1-4 S/U in their last five games when favored by three points or less. Will Brady buck that trend?"
NFL playoff picture Week 17:Bills, Chiefs, Bengals in fight for No. 1 AFC postseason seed
NFL power rankings Week 17:Green Bay Packers, Pittsburgh Steelers surge with victories
Reach Jeremy Cluff at firstname.lastname@example.org. Follow him on Twitter @Jeremy_Cluff.
Support local journalism: Subscribe to azcentral.com today.
This article originally appeared on Arizona Republic: Carolina Panthers vs. Tampa Bay Buccaneers predictions for NFL Week 17

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