Sanofi is merging its real-world data platform with New York startup Aetion’s similar evidence platform to augment its treatment development and deployment efforts, the companies announced today. Sanofi’s DARWIN platform will provide a substantial body of de-identified patient data, which the Aetion Evidence Platform will analyze those information for insights on drug effectiveness, safety and value.
“Today marks another important step in Sanofi’s digital transformation,” Dr. Bernard Hamelin, global head of medical evidence generation at Sanofi, said in a statement. “By integrating these platforms, we strive to make faster, more informed decisions with the potential to lead to first-in-class and best-in-class treatments that could change the practice of medicine.”
Bright.md’s online triage and virtual care platform will soon be deployed across Mercy’s health system, the companies announced last week. The startup’s tool is intended to handle remote patients with relatively minor health concerns, thereby freeing up the system’s providers to direct their focus on patients with more pressing needs.
“Mercy is committed to creating a system of care focused on the needs of those we serve, when and where they need health care,” Dr. Gavin Helton, Mercy’s SVP of population health, said in a statement. "Through functionality enabled by Bright.md, we can enhance access to high-quality Mercy care to our current patients and expand our outreach to people we aren’t currently serving.”
ActiGraph’s FDA-cleared sleep and activity monitoring tech is now at the heart of Signant Health’s electronic clinical outcome assessment platform TrialMax thanks to a new arrangement between the companies. This integration allows researchers to collect and record these data via connected research-grade wearables.
"It's important that patients continue to experience trials that benefit them without burdening them,” Bill Byrom, Signant Health’s VP of product strategy and innovation, said in a statement. “Using ActiGraph's devices not only provides a simple and efficient experience for patients, it also simplifies and streamlines trials for sites and sponsors while offering better data and insights."
Syneos Health, a biopharmaceutical organization that houses a contract research organization and a contract commercial organization, is expanding an ongoing strategic partnership with AiCure to streamline clinical trials and improve patient engagement. AiCure, which recently collected new funds, will provide its software’s unique ability to evaluate facial, verbal and other movement variables to Syneos’ projects, alongside dashboards and other tools to improve operational efficiency during clinical trials.
“The AiCure platform aligns with our unique product development model that harnesses behavioral insights to unlock real world experiences,” Alistair Macdonald, CEO of Syneos Health, said in a statement. “By deploying the AiCure platform to our investigative sites, we create insights-enriched patient communities to advance clinical research. This collaboration reinforces our Dynamic Assembly philosophy where we join forces with the latest and most agile data and technology partners to address our customers’ needs.”
Hot on the heels of some M&A news, AI monitoring and decision support platform Biofourmis announced that it would be teaming up with pharma giant Novartis for the commercial rollout of a platform that uses predictive analytics to manage heart failure in patient populations.
The technology will use Biofourmis’ AI and the recently acquired Everion sensor, and will take the form of a product to help predict and analyze drug therapy. The companies will start with the commercial roll out in Asia with plans to expand to the US and beyond.


text:
Thursday, 20 November 2014 - 09:56
F-16s, Sanctions & Diplomacy: New Dutch policy for Russia
According to Minister Bert Koenders of Foreign Affairs, the relationship with Russia should be reconsidered. He said this in the Second Chamber yesterday. Koenders has "serious concerns" about the latest developments, such as the destabilization in the Ukraine and the "rhetoric and intimidation" from Russia. The fact that Moscow is not looking for "political solutions" with the West, worries him even more. He things the greatest risk is that "new dividing lines" will be created in Europe. He suggests three points ahead in the policy for Russia. Firstly, NATO should be strengthened in order to defend their own safety. For this Dutch F-16's is patrolling in the Baltic airspace, to reassure Estonia, Latvia and Lithuania. Secondly, the economic sanctions against Russia should be continued. "The sanctions do indeed hurt Russia and they work." The third element of the policy is to continue seeking a political solution and a "new balance in our relationship with Russia". Koenders does not agree with isolating Russia, because, according to him, that is not in the best interest of Europe's safety. Recalling the Dutch ambassador, as pleaded for by Member of Parliament Louis Bontes, is not on the agenda. Koenders believes in diplomacy - an ambassador is especially necessary when things are difficult.

domain: politics


text:
Defined by a strong silhouette, this exquisitely tailored form has a supportive and comfortable bench sit. Resting atop you will find five throw pillows that invite an opportunity for creative fabric application and offer an additional level of comfort. The Presidio Sofa rests on an exposed wood base with optional brass ferrules on the front legs.
- One (1) Baker Comfort weltless seat
- Two (2) Baker Comfort Plush weltless boxed TPs 14" x 24" x 2.5"
- Three (3) Baker Comfort Plush KE weltless TP one (1) 11" x 25" two (2) 19" x 19"
- Brass ferrules on front legs (upcharge)
- Welt trim on base only
- Exposed Beech wood

domain: design


text:
New transparency rules will require councils to publicise to the press and public the little-known rights to inspect councils’ detailed financial accounts, ledgers and records. This is designed to increase scrutiny of councils’ spending decisions by armchair auditors and local investigative journalists, Local Government Secretary Eric Pickles said today.
Every year councils are required to open their accounting records for public inspection and challenge over a set time period. Yet the public often do not realise that these citizens’ rights include checking not just the accounts but also “all books, deeds, contracts, bills, vouchers and receipts related to them”. These rights allow the public to check any spending under the £500 online transparency threshold, and avoid the need to submit Freedom of Information Act requests.
Revised rules controlling local authority accounting and audit practice have been introduced reinforcing the importance of local transparency, audit openness and accountability. These inspection rights last for 20 working days, but the period differs for each local authority, resulting in a low take-up to date. So in addition to the existing requirement to notify the public of their rights through the local press, councils must now also highlight the opportunity on their website.
In a deregulatory move, changes will also reduce the financial bureaucracy and burdens imposed on the smallest local authorities, streamlining the audit process to make it easier for authorities to be accountable to their community.
Until now, any public body with a budget over £1m had to provide comprehensive accounting and audit details, which hit smaller authorities such as parish councils disproportionately. These budget thresholds have now risen to £6.5m, meaning that up to 100 smaller local bodies will immediately benefit from less burdensome audit requirements, reducing costs on reporting duties imposed by Whitehall.
Communities and Local Government Secretary Eric Pickles said:
An open Government is vital for good democracy and that’s why councils have to open their ledgers to the public - everyone has a right to know how their taxes are spent.
But it’s not enough to just publish them quietly, armchair auditors and local journalists need to know exactly where to find that information and these new changes will make sure they are not just out in the open but under the spotlight too.
We have also cut the red tape for the smallest councils. For too long they have been hostage to the most complex demands from Whitehall, eating into time and resources they could have used to deliver for their community, whilst maintaining robust safeguards on the spending of public money.
Notes to editors
Case studies on the exercise of these rights can be found at: www.orchardnews.com/casestudies.htm (external link).
1. The revised Accounts and Audit (England) Regulations 2011 now include the following notification requirements:
the period during which the accounts and other documents will be available for inspection
the place at which, and the hours during which, they will be so available
the name and address of the auditor
the right to make objections at audit; and
the date appointed for the exercise of rights of electors.
As soon as reasonably possible after conclusion of an audit, a larger relevant body must give notice by advertisement and on its website stating that the audit has been concluded and that the statement of accounts is available for inspection by local government electors and including:
- a statement of the rights conferred on local government electors
- the address at which and the hours during which those rights may be exercised; and
- details of where the statement of accounts can be found on the body’s website
2. In addition the new rules raise the threshold below which a local body is classed as a smaller body from £1m to £6.5m annual income or expenditure. This is based on the definition of small companies in the Companies Act.
3. Changes to the regulations came into effect on 31 March 2011 meaning affected authorities can apply the changes to their 2010 - 2011 accounts due to be published shortly. The full regulations can be found at: www.legislation.gov.uk/uksi/2011/817/contents/made (external link).
4. Any body which enjoys the freedoms given by the Prudential Capital Finance System is excluded from the smaller body category.
5. Smaller body status means that the body can prepare a simpler set of year end accounts, and is subject to a less demanding system of audit scrutiny. Those without websites are being encouraged to consider how else they can make their community more aware of their rights. Larger parish councils, internal drainage boards and joint committees of principal local authorities will be the main types of body affected by the change.
6. The procedure for councillors to approve the accounting statements of the larger bodies will also change to allow them sight of audit findings before they are asked to give their approval.
7. Enforcement of these regulations in the past has relied on audit review and civil law obligations, and this will continue in the future. Criminal sanctions have been removed, as they have not been invoked in recent years and since Coalition Ministers believe such criminal sanctions are disproportionate.
Keep up to date with the Department by following us on Twitter (external link).
Visit our newsroom contacts page for media enquiry contact details.

domain: law


text:
To Rt. Honourable Prime Minister of Nepal
H.E. Mr. Sher Bahadur Deuba
RE: Call for Action in Transforming Education in Nepal
RE: Call for Action in Transforming Education in Nepal.
I am Sushmina Baidya. I have been actively working with children and young people in my community. I am also a member of the Transforming Education Summit Action Group which is supported by the United Nations Foundation under the Unlock the Future Coalition.
I was born and raised in Kathmandu in a family of five. My parents gave birth to three daughters in a community where patriarchy saliently paces its way. In a way, I always felt our family was a silent rebel. I am not saying this just because we were a dominantly female family. Gender inequality was never about fighting between sexes or which gender outnumbered the rest. It is the fight against patriarchal constructs. The silent screams of people whose existence were questioned – and life choices denied for who they are and who they wanted to become. My elder sister and her husband chose to stay at our home after marriage, withstanding extreme social criticism. My other elder sister opted to adopt a child with her husband in a society where birth of your own offspring is regarded as the symbol of successful marriage. This is why I always believed my family was a silent rebel.
Somehow, the rebellion characteristics grew in me when I was 15 years old and studying in grade 10. My school introduced a system of reshuffling students into sections, as per the internal grades, in the last leg of the academic year, in order to “produce” academically excelling students. Not adhering to the new system, which we felt was discriminatory, a silent protest was organized. Neither did we allow students to relocate nor the teachers to continue the classes. After three days, the administration called a meeting and decided to lift the system.
When the administration called us for a meeting, I remember finding myself in the biggest auditorium that my school had. On the podium stood our former Program Coordinator who seemed vividly upset. For the first time, the entire school resisted. The protest was a mere symbol of resistance. What it represented was the resistance towards the existing hegemonic relation between students and teachers – the pedagogical practice of authoritative teaching. At that moment, I realized that there is a need to dismantle the entire education system, not just in Nepal but globally.
I urge your excellency to take the following implementation into consideration.
Pedagogical teachers’ training
To begin with, we need to look at the existing learning practices. This does not mean the way teachers ‘teach’ the students. When we think about pedagogical practices in teaching, we tend to automatically think about the responsibility of a teacher in class. Pedagogical practices in teaching is not only a responsibility of shifting teacher’s practices. It is the interconnection among engaged pedagogical practices, body and mind connection, and conversation on lived experiences and passion. Let me give you an example – I took a class on ‘Researching children and childhood’ and one of the modules was Autobiography. This was, by far, the most memorable class I have taken. We started the class by sharing our own recollection of life stories where our childhood was shaped by gender, class, race, ethnicity or any other social constructs. This class was not solely driven by the lecturer. Instead, the lecturer facilitated while the students directed the class. The lived experiences helped us unpack the subjectivity of the discourse.
Revision of curriculum
While we reevaluate the pedagogical practices in education, we have to give a hard look at the curriculum. Young people across the globe are demanding a radical change in the education system, specifically the curriculum. The constant shift in the labor market, future skills of work, and the change in the social and cultural capital acquisition means a revision is needed in the curriculum. There is a need to change the curriculum that caters to the skills for the future of work.
Prioritize community based learning
Illich (2007) in his book Deschooling Society discusses how education, as a right, is subsumed as a value of personhood. One of the reasons is the uniformity of the education system – which I prefer to term as colonial education. Colonial education disregards the community based value systems to integrate in the education system. For instance, vernacular education is not considered as formal unless it is offered by a formal institution. Learning by doing is not accredited as formal education unless backed up by an institution with students wearing uniforms. This suggests the risk of uniformity in curriculum that fails to engage the community in the learning process. Therefore, value-based learning in curriculum needs to be integrated if we are to revise the curriculum.
Changing the education system seems ambitious at the moment but welcoming democratizing practices in classes using engaged pedagogy, revising curriculum, and integrating community value-based curriculum in education can be realized. As we move towards organizing the pre-summit on Transforming Education (on June 28-30) and the Summit itself (in September), I am hopeful it will create a space to initiate conversations and make commitments for transformation. I visualize the Summit as a space where we can dig deeper into the conversation of understanding the purpose of education, and to take actions to co-create an education system that is more inclusive.
I shall leave with a beautiful piece written by Bell Hooks in her book Teaching to Transgress.
The academy is not a paradise. But learning is a place where paradise can
be created. The classroom, with all its limitations, remains a location of
possibility. In that field of possibility we have the opportunity to labor for
freedom, to demand of ourselves and our comrades, an openness of mind
and heart that allows us to face the reality even as we collectively imagine
ways beyond boundaries, to transgress. This is education as the practice
I hope this piece of her artwork will shed light on the conversation and commitments the Summit will achieve and inspire the government of Nepal to submit its National Statement of Commitment to the Summit before its deadline in August. We need to collectively work on creating the urgency of reimagining education – transforming how the education system fully integrates in the life of a person.
I hope we ponder upon the purpose of education and seek answers to openly welcome radical changes to education – one that embraces diversity, inclusivity, passion and vulnerability.
I hope to see you all as we wander together in this quest of Transforming Education.
Thank you for your time and consideration.

domain: sociology


text:
Rahul Banerjee entered the pre-quarterfinals of the men’s individual event after comfortably beating Janstan Gantugs of Mongolia 6-0 at the historic Lord’s Cricket Ground here.
Banerjee provided some cheers in an otherwise dull day for the Indian archers as both Jayanta Talukdar and Chekrovolu Swuro earlier today crashed out in the opening round of the men’s and women’s individual events,respectively.
In individual events,which is decided on best of five sets (three arrows each),one who wins a set irrespective of the margin gets two points.
Banerjee,who scored a total of 84 points as against 75of his opponent,hit a total of six 10s in three sets.
In the third set,he had three perfect 10s that helped him seal the match.

domain: news


text:
An Eerie Quiet Along Georgia’s ‘Border’ with South Ossetia
With Putin’s invasion of Ukraine failing, Will Neal looks at the Kremlin’s ‘frozen’ conflict with another neighbour. Will Russia try to score a victory there?
Valia Vanishvili lives in Bobnevi. Rather, she lives in half of it. Her village falls squarely along the ‘administrative boundary line’ between Georgia and the occupied territory of so-called South Ossetia. Several years ago, she and her husband woke one morning to find Russian soldiers building a barbed wire fence across the foot of their orchard. It took them two weeks, and she’s been trapped on the other side ever since.
With the outbreak of war in Ukraine, Georgia’s delicate geopolitical situation, as a country where more than twenty per cent of its sovereign territory is controlled by Russia, has been thrown into sharp relief. So far, with its hands full executing Putin’s ‘special military operation’, Moscow has shown little appetite for stoking tensions in the borderlands, perhaps also owing in part to a notably muted response to the conflict from the ruling Georgian Dream party.
However, Georgia’s president has warned that now is not the time for falling asleep at the wheel, with renewed interest from South Ossetian authorities in the issue of contesting the boundary line begging the question of how long this calm is likely to last.
All Quiet on the Western Front
Since the earliest days of independence from the Soviet Union, ethnic conflict in Georgia has seen Russian forces stationed in the separatist regions of Abkhazia to the west and South Ossetia in the north. After an armed confrontation near the South Ossetian capital of Tskhinvali escalated into a twelve-day war between Russia and Georgia in 2008, the Kremlin formally recognised these territories as sovereign states, with its soldiers remaining posted in both today.
While the invasion of Ukraine initially raised alarm over the prospect of renewed aggression from Georgia’s breakaway regions, the European Union’s Monitoring Mission in the country says the situation along the administrative boundary line has proven, all things considered, relatively quiet. The Georgian government has also adopted a largely neutral stance on the conflict, repeatedly declining to join sanctions against the Putin regime despite widespread international criticism, in an ongoing bid to avoid provoking Moscow.
Even so, Georgian president Salome Zurabishvili noted in a recent interview that the situation remains unpredictable. “I don’t think Russia will invade Georgia now, but we are already seeing the humiliation of Russia and the fact that they are losing this war,” she told the BBC. “They made a lot of miscalculations, and maybe, at some point in time, for internal reasons, Russia will be tempted to score points in Georgia, where it is easier.”
Last year, the South Ossetian parliament set up a commission to review the current placement of the de-facto border. Specifically, “a discrepancy [of] more than 200 sq. km” just west of the occupied region, “to the detriment of the legitimate territorial interests of the Republic.” That commission has since finished its preliminary inquiries, with its findings apparently soon set to be passed back to the chamber for further debate.
What this may mean for future relations with the breakaway territory is an open but nevertheless fraught question. Ian Kelly, a former US ambassador to Georgia, speculates that renewed talk of the issue may indicate Russia’s willingness to test the balance of tensions in the region, but that ultimately, allowing the line to be contested right now would make little strategic sense. “I don’t see that it’s necessarily in [Russia’s] interests to destabilise this government, given that Georgian Dream is playing along,” he says. “While it could be a trial balloon of sorts, to see how they respond, I’d be surprised if they pursued it.”
Director of the Georgian Institute of Politics, Kornely Kakachia, offers a similar assessment but stresses it’s important to assume a longer-term view of Georgian security. “It all depends what kind of situation Russia will find itself in with Ukraine, in terms of Putin’s image,” he explains. “If they decide for the sake of public opinion, especially with him up for reelection in the next two years, they need a success story, well then they could start a new war.”
For David Katsarava, founder of the activist group Strength in Unity, which monitors the de-facto border, the issue is far more clear-cut. “This plan, unfortunately, is entirely realistic, and I believe so-called South Ossetia will do their best to realise it,” he says. “If there’s a reason it hasn’t started yet, it’s the war in Ukraine, but I’m ninety-nine per cent sure it will happen. It’s just a question of when.”
That relations with South Ossetia have proven relatively calm for the time being is not to say there’s any real quality of life to be had for people immediately on either side of the line.
Valia Vanishvili owns a small farm. Two cows, a few chickens. There are pear and apple and walnut trees in her orchard, intersected by rolls of razor wire that cut through the heart of Bobnevi, a short drive north of Tbilisi. “I’ve not received my pension in five months. If I try to cross the wire, I’ll be arrested,” she says. “I cannot visit my daughter who lives on the other side. Ever since my husband died I’ve not been able to embrace her, and I can’t go to his grave, because the Russians don’t allow me.” As Vanishvili speaks, two border guards move through the bushes further down the hill to take up post behind a wooden shack, watching her every move. She’s eighty-nine years old.
Her story isn’t unique. The issue of “creeping borderization” – Russian forces erecting fences and other structures along the de-facto border, often further forward than demarcated by the official line – has since 2008 been repeatedly condemned by intergovernmental organisations and monitoring agencies on the ground. South Ossetia’s prohibition against almost all humanitarian agencies entering the region also means there are few if any formal channels for Vanishvili to get help running her farm, obtaining basic household items, or even access to medical care. More often than not, she has to rely on Katsarava, who visits when he can to discreetly hand groceries and other things she needs through the barbed fence.
“It’s a very dangerous life. Most of these Georgian citizens, they receive absolutely no attention from our government,” Katsarava says. “From time to time we run campaigns to raise financial support, but it’s difficult to cover all their needs because we just don’t have the funds, and so they have no real support.”
Asked if she’s ever considered leaving, under a program facilitating the reunion of families separated by the conflict, Vanishvili explains it was her husband’s dying wish their property should not fall into Russian hands. It’s her home of sixty-two years, she insists, and it’s where she’ll stay.
The Doctor of Tskhinvali
Creeping borderization is only one tool used by South Ossetia to further control of the areas surrounding the boundary line, going hand in hand with a kind of glacial psychological warfare Katsarava calls the establishment of “fear zones.” This relates not only to the ongoing harassment of people like Vanishvili, who says guards routinely accost her and her daughter, accusing them of illegally distilling vodka, but also targeted kidnappings from within Georgian territory.
“Fear zones are the areas along the occupation line and within the territory controlled by the Georgian government which [have] turned into places where the local population are scared to go, because of Russian occupiers’ threats, robbery, kidnapping and other violence,” an info pack from Strength in Unity states. “As part of [a] soft power war, psychological terror forces [the] depopulation of these places, which is one of the goals of the occupying forces.”
According to Vazha Gaprindashvili, president of the Georgian Society of Orthopaedic Traumatologists, border guards in South Ossetia are actually entitled to perks for making detentions, such as a raise and extra vacation, meaning there’s effectively a bounty out on Georgian citizens. He knows well the trauma of these kidnappings, having himself been detained in 2019 while attempting to visit a patient on the other side of the line.
What set Gaprindishvili’s case aside was that he refused to sign a document declaring he understood he’d entered South Ossetian territory. Many do, and are sometimes able to escape with little more than a fine. Instead, he was taken to a detention centre in Tskhinvali and sentenced to almost two years in prison. In the end, he was freed after just a couple of months, but only because his capture, as a medical professional attempting to help a patient, caused something of a minor international scandal. He’s grateful for the support that secured his release but acutely aware that others are not always so lucky.
“The people in that first cell with me, all of them were injured, one of them badly, his nose was broken,” he says. “The way they detained him, he was out walking with his ten-year-old child when they came across the guards. They beat him with the butt of their rifles and took him away, leaving the child behind alone.”
‘An Illegal Decision by an Illegal De-Facto Government’
Georgia’s Ministry for Reconciliation and Civil Equality, the department charged with monitoring relations with the occupied territories, declined to be interviewed for this story, simply stating that any debate regarding the administrative boundary line by the South Ossetian parliament could only result in “an illegal decision by an illegal de-facto government.”
For Giga Bokeria, a former secretary of the National Security Council and now chairman of the opposition party Movement for Liberty – European Georgia, the government’s muted response to the war in Ukraine reflects a more general policy of “appeasement” toward the Kremlin, one that is only imperilling ties with historic allies at a time when every effort needs to be made toward strengthening them. “Georgia needs to be more protected – that’s the argument we should be making now in Washington and Brussels, where there is finally, if belatedly, a much more sober understanding of Russia’s threat to Euro-Atlantic security,” he says. “Instead, we have this situation where Georgia’s geopolitical standing is deteriorating, and it’s a treasonous mistake to be making.”
Even after ten months, perhaps it is simply still too soon in the day to know what exactly the wider fallout of war in Ukraine will be. At present, as Kornely Kakachia points out, so much remains uncertain, both in terms of what victory or defeat might look like for either Russia or Ukraine, much less what consequences either outcome is likely to have for Georgia. One thing, however, he says is clear. “What the government is trying to do [by remaining neutral], it’s a mirage, and it will not pay off in the long term,” he explains. “Putin’s strategy, he wants to rebuild something like the 19th century Russian Empire, and to have an independent Georgia, that’s simply not acceptable.”
Meanwhile, life for Valia Vanishvili continues much as it has done for the past fourteen years. Her only certainty – a kind of managed, protracted instability. Days spent alone in the orchard, just a few feet and yet a chasm between her and her daughter, picking walnuts under close watch by the wire.

domain: geography


text: The growing process of winter wheat is simulated by CERES-wheat model assuming the daily temperature variation to be-1℃, 0℃, 1℃, 2℃and daily precipitation change to be - 20% ,-10%,-5%,0,5%,10%,20% respectively. The case study site is of zhenjiang,Jiang-su Province, which locates in the middle east of China. The simulation results show that the impact of temperature variation on winter wheat is stronger than that of precipitation change. Warming climate can speed up the development rate and shorten the phenological period. In ge-neral,the adverse effect of climatic change on grain yield is greater than that of its beneficial effect, especially when the climatic cooling and drying. Both the temperture increase and precipitation decrease can reduce the plant extractable soil water content.

domain: agronomy


text:
Fourteen White Supremacists Indicted on Federal Racketeering Charges
Las Vegas, Nev. – Fourteen individuals have been indicted by the Federal Grand Jury on charges they are members of a white supremacy gang whose members operated within the Nevada state prisons as well as in the local communities to engage in acts of violence, including murder, extortion, corruption, illegal gambling, distribution of controlled substances, identity theft and credit card fraud, announced Steven W. Myhre, Acting United States Attorney for the District of Nevada.
"Racist gangs in our prisons use corruption and violence to undermine the safety of both prison staff as well as the inmates who refuse to become involved in hate groups," said Acting U.S. Attorney Myhre. "The gang members charged in this indictment are alleged to have engaged not only in violence and crime in our prisons, but also of extending their reach outside prison by distributing methamphetamine and other drugs on the streets of our cities, threatening and extorting money from inmate families, and stealing and using false and fraudulent identification documents and credit cards, all in an ongoing effort to finance and spread their message of hatred and racial supremacy throughout Nevada. This investigation and prosecution demonstrates the commitment of our state and federal partners to aggressively deal with the dangers that gangs present to the prisons as well as our communities."
The Indictment, returned on Tuesday, July 10, 2007, and unsealed today, charges the 14 defendants with Conspiracy to Engage in a Racketeer Influenced Corrupt Organization (RICO). Three defendants are also charged separately with acts of Violent Crime in Aid of Racketeering (VCAR), specifically Conspiracy to Commit an Assault With a Dangerous Weapon. Names of the defendants charged are listed at Page 6 of this News Release. Thirteen defendants are scheduled to appear tomorrow, Friday, July 13, 2007, at 9:30 a.m. for an initial appearance and arraignment and plea before United States Magistrate Judge Peggy Leen. The initial appearance and arraignment for the remaining defendant (Sellers) is scheduled for Friday, August 24, 2007, at 8:30 a.m. before United States Magistrate Judge Lawrence R. Leavitt.
The Indictment alleges that the defendants are members of the "Aryan Warriors," a criminal organization that operates both inside the Nevada prison system and in communities in Nevada. Historically, the Aryan Warriors organization has focused on the protection of white inmates and the promotion of white supremacy within the Nevada prisons. The gang asserts control over other prisoners through violence and extortion. Members of the gang inside Nevada prisons also corrupt guards, distribute illegal drugs, and run extensive illegal gambling operations. More recently, the Aryan Warriors have sought to expand their focus by the establishing of a "street program" for illegal activities for profit outside the prisons in the Las Vegas, Henderson, Pahrump, and Reno communities.
The Indictment alleges that members of the Aryan Warriors adhere to a written manifesto which promotes supremacy of the Aryan race and establishes certain positions or ranks within the enterprise, such as horn holders (leaders), bolt holders (full members), prospects (potential members), and associates (non-members who are affiliated with the organization.) The manifesto directs Aryan Warriors members and prospects to gain access to computer records, prison records and court records, and to elicit communications with prison staff for the purpose of identifying inmates and prison staff who they perceive as against their racial cause and a danger to their illegal activities.
The indictment further alleges that Aryan Warriors involved in the "street program" earn money through the distribution of drugs and other crimes within local Nevada communities. Drugs are provided to women and prison guards who smuggle the drugs into the prison. Aryan Warriors also use members, girlfriends and associates operating outside the prisons in the local communities to steal or fraudulently obtain identification documents and credit cards to steal cash or merchandise or to assist in concealing their identities in other criminal conduct. Aryan Warriors use cash earn in the "street program" to support other criminal activities of the gang and to financially support incarcerated Aryan Warrior leaders by placing money on the prison accounts.
Aryan Warriors allegedly corrupt guards and prison staff through bribery, including payments of both money and drugs. They use bribed guards to discourage guard oversight of their activities, to bring drugs into the prison, to control the prison yards, to operate gambling activities, to gain access to communications equipment, and to obtain paperwork or prison office assignments so they can identify inmates who can be extorted.
In addition to the racketeering conspiracy charge, the Indictment alleges that on about August 10, 2001, defendant Sellers and others, conspired to assault inmate Jacob Armstrong with a knife. Armstrong died as a result of the assault. On October 16, 2004, defendant Daniel Egan and others conspired to assault inmate Mark Fechtman with a razor-like instrument; on January 4, 2005, defendant Daniel Egan and others conspired to assault inmate Cody Dunn with a knife; and on February 19, 2007, Kenneth Krum and others conspired to assault William Gochenour with a baton inside a residential home.
"The goal of this investigation, accomplished by these arrests, was to significantly dismantle the Aryan Warriors organization by removing its leadership in the Nevada prison system and disrupting its street program, which is primarily involved in the manufacture and distribution of methamphetamine and marijuana within Nevada Department of Corrections institutions and in Las Vegas, Pahrump and Reno," said Steven Martinez, Special Agent in Charge of the FBI for Nevada.
"These arrests are an important step in putting a stop to this type of activity in Nevada's prison system," said Nevada Attorney General Catherine Cortez Masto. "My office is working closely with the U.S. Attorney's office in prosecuting these inmates and we will also work with the Nevada Department of Corrections to prevent this type of activity from happening in the future."
If convicted, the defendants face up to life in prison and a $250,000 fine on the Conspiracy to Engage in a Racketeer Influenced Corrupt Organization charge. Defendants Sellers, Egan, and Krum face up to 20 years in prison and a $250,000 fine on the Violent Crimes in Aid of Racketeering Charges.
The case is being investigated by the FBI and Nevada Department of Corrections Inspector General's Office, and prosecuted by Assistant United States Attorneys Eric Johnson and Kathleen Bliss, with assistance from the Nevada Attorney General's Office. Other agencies that have contributed to the investigated are the Las Vegas Metropolitan Police Department and the Bureau of Alcohol, Tobacco, Firearms and Explosives.
The public is reminded that an indictment contains only charges and is not evidence of guilt. The defendants are presumed innocent and entitled to a fair trial at which the government has the burden of proving guilt beyond a reasonable doubt.
U.S. v. Ronald "Joey" Sellers, et al.
- Defendant Name, Age, Residence, Custody Status
- Ronald "Joey" Sellers, 39, Nevada Prison System
- Daniel Joseph Egan, 32, Nevada Prison System
- James Milton Wallis, 46, Nevada Prison System
- Ronnie Lee Jones, 47, Las Vegas, Arrested 7/12/07
- Guy Edward Almony, 35, Nevada Prison System
- Tony Howard Morgan, 38, Las Vegas, Arrested 7/12/07
- Kenneth Russell Krum, 37, Las Vegas, Arrested 7/12/07
- Charles Edward Gensemer, 43, Las Vegas, Arrested 7/12/07
- Kory Allen Crossman, 34, Federal Custody (prior charges)
- Michael Wayne Yost, 53, Pahrump, Arrested 7/12/07
- Charles Lee Axtell, 47, Nevada Prison System
- Scott Michael Sieber, 39, Nevada Prison System
- Jason F. Inman, 32, Nevada Prison System
- Robert Allen Young, 29, Nevada Prison System


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David Dimbleby highlighted Emily Maitlis’ comments about the BBC and described her Dominic Cummings monologue as an ‘argument’ during a scathing interview on the broadcaster’s Today programme.
The Question Time veteran and TV presenter, 83, said her monologue, which was found to have violated the BBC’s fairness rules, should have been worded as a question rather than a statement.
He pointed out that it’s not just Miss Maitlis who has been reprimanded by the broadcaster – but the entire Newsnight team.
During the controversial monologue, Ms Maitlis said in May 2020: ‘The country could see that Cummings broke the rules, which shocked the government it couldn’t.
‘The public mood was one of anger, contempt and suffering.’
Veteran question-and-answer host and TV presenter David Dimbleby, 83, said Emily Maitlis’ monologue about Dominic Cummings was an ‘argument’
Mr Dimbleby told the Today programme: ‘Well, not everyone can be shocked … maybe but it’s a question to ask.
‘It was a polemic. I think that is a mistake. ‘
Ms Maitlis’ comments followed the revelation that top 10 aide Dominic Cummings had traveled from London to Durham after testing positive for coronavirus, including a visit to the now famous Barnard Castle.
The Prime Minister backed Mr Cummings at the time, who later resigned in November 2020.
The BBC received more than 40,000 complaints in two days about the broadcast – both from those angry with her comments and those upset with the BBC’s decision to say it broke the rules.
Former Newsnight presenter Emily Maitlis told the Edinburgh audience: ‘It doesn’t make any sense for an admirable institution, known for its strict procedure – unless it can send a message of reassurance. directly to the government?’
Ms Maitlis, 51, who left the BBC this year to join media group Global, told the Edinburgh TV Festival this week that the company had ‘tried to appease’ No 10 by issuing an apology. ‘within hours”.
She asked if the BBC was ‘perhaps sending a message of reassurance directly to the Government.’
Focusing on the BBC’s speed of response, she said: ‘Why did the BBC immediately and publicly seek to confirm the Government spokesman’s opinion? Without any kind of procedure?
‘What does that mean for an admirable organization known for its strict procedures – unless it can send a message of reassurance directly to the Government?’
Mr Dimbleby also disagreed with Ms Maitlis’ comments, as well as statements made about BBC board member Sir Robbie Gibb, who she described as ‘former Downing Street shooting doctor, and is a former consultant to rival BBC GB News’.
He said: ‘I don’t think it’s right to have a bunch of Tory supporters at the BBC.’
He continued: ‘There will always be collisions with the government, and indeed with the opposition because they always try to lean on the BBC and sometimes the BBC is wrong. ”
‘It’s kind of political football, BBC. We have to believe that. ‘
Listeners quickly took to social media as the BBC’s war of words unfolded. Although some agree with Mr Dimbleby, many also support Ms Maitlis.
In her own speech in Edinburgh, BBC Content Director Charlotte Moore insisted there was ‘no influence from the Government or the board’ over the BBC over the decision to rebuke Maitlis.
She added: ‘As we have made clear previously in relation to Newsnight, we have not taken action due to any pressure from Number 10 or the Government and the other suggestion is false.’
Ms Moore said fairness was ‘particularly important to the BBC’, adding that she felt viewers expect it from the broadcaster, especially when it comes to politicians being held accountable. duty.
Ms Moore also said she wished all the senior staff who had left the BBC over the past year well and said the departure provided a great opportunity for new talent to take their place.
A BBC spokesperson previously said: ‘The BBC places the highest value on fairness and accuracy and we apply these principles to our reporting on all matters.
‘As we have made clear previously in relation to Newsnight, we have not taken action due to any pressure from Number 10 or the government and the other suggestion is false.
‘The BBC found the show violated its editorial standards and that decision remains in effect.’


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Hand Painted Pink Dreidel
This hand painted pink dreidel is ready for game play or add to your collection! Give as a unique Hanukkah gift, too! It is a deep pink with purple and blue hebrew letters painted on the sides. Black accent lines add to the design. The dreidel is 2 1/2 inches high and 1 1/8 inches wide. It comes with a blue gift bag and black display stand.
Please select all options.

domain: hobby


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Accounting and finance leaders show increased confidence in the economy in the second quarter, according to recent IMA/ACCA research, leading companies to focus more on growth and investment strategies. In this conversation, Susan Sobbott, president of Global Corporate Payments at
This interview has been edited and condensed.
Jeff Thomson: American Express and CFO Research recently released the 2014 Global Business and Spending Monitor, which surveyed senior finance executives at large companies around the world. What is the economic outlook from CFOs globally?
Susan Sobbott: As a post-recession recovery takes hold, we’re seeing stronger overall confidence among CFOs, who predict economic expansion in the coming year. The differences between regions are also starting to shrink. In previous years, CFOs in emerging economies tended to predict growth, while those in developed economies remained more conservative. Europe is largely responsible for the increase in confidence this year. More than two-thirds (68%) of European CFOs are predicting expansion, up from 48% in 2013.
CFOs in the United States echoed this global trend, with 75% predicting economic expansion, a slight rise from the year before. The rise in confidence in both Europe and the U.S. brought them closer to countries such as China and Brazil, which both moderated their economic expectations this year.
Thomson: How is this economic outlook impacting CFOs’ investment and growth strategies?
Sobbott: Most spending and investment plans remained relatively level compared to 2013. Overall, 56% of CFOs plan to take a moderate approach to spending and investment, which is the same as last year. Though most CFOs plan to proceed with restraint, the report showed that the percent of respondents planning to take an aggressive stance toward spending and investment nearly doubled – from 10% in 2013 to 17% in 2014.
U.S. CFOs are among the most conservative when it comes to spending and investment, despite their prediction that economic expansion is on the rise. In particular, the U.S. has the lowest average increase in planned spending and investment – just 5%, less than half of the 11% survey average.
Thomson: According to your research, CFOs are tending to seek “aggressive investment and tightly controlled spending.” Why and how are CFOs executing this seemingly paradoxical approach?
Sobbott: The Global Business and Spending Monitor report indicates there is a mixture of hope and skepticism influencing how CFOs think of, and approach, spending and investment plans. While the overall trend on economic expectations this year has been upward, many CFOs likely remain somewhat wary, having experienced the economic rises and subsequent dips of previous years. With that in mind, there are those CFOs who plan to make trade-offs – cutting into shorter-term spending in order to fuel investments for longer-term growth. For example, one executive surveyed stated that “investment in innovation, particularly R&D” would be funded by “cutting in other areas.”
In general, though, spending and investment plans will remain steady this year, with fewer CFOs focused on cost control. Overall, nearly all companies anticipate higher levels of spending and investment over the next year – 47% say their companies’ spending and investment will increase by up to 10%, and another 42% are expecting increases of more than 10%.
Thomson: How have CFO responsibilities changed throughout the life of the Global Business and Spending Monitor report?
Sobbott: Over the years, finance executives have grown in both influence and reach, pushing beyond functional boundaries and involving themselves in decision-making across their organizations. In 2013, nearly two-thirds of CFOs (64%) said that the global economic downturn enhanced the finance function’s profile and influence at their companies. This jump was even more notable in the U.S., where 85% of CFOs reported an increase in influence.
Responses from around the world in 2013 and 2014 indicate that CFOs are well positioned to actively contribute to business growth and expansion. Today, CFOs are frequently found discussing business challenges not only with their CEOs, but also with the company’s leaders in operations, marketing, IT and administration.
Thomson: According the report, that increased influence means CFOs are now leading a “can-do” culture. What does this mean, and how is this different than past cultures?
Sobbott: The CFO is more likely to be seen as a potential catalyst as companies become more focused on growth. Organization leaders are recognizing the importance of making finance part of the business decision-making process early on, rather than relegating it to a post hoc adviser role. With that cultural shift, we see companies moving to – as one CFO states – a “how-do-we-do-this” mindset, rather than a “why-we-can’t-do-this” mindset.
What’s more, the finance function is also perfectly positioned to help companies strike the right balance between this “can-do” attitude of improving prospects and the need to maintain control over costs in still uncertain environments.
Thomson: Despite that increase in influence and the “can-do” attitude, your report says CFOs feel undervalued. Why is that, and what are the potential effects?
Sobbott: In recent years, we’ve seen that CFOs recognize the growing influence of the finance function. What they may not realize – as we saw in this year’s survey – is just how much their insight is valued by their CEOs, and how much it is a determining factor in business decision-making.
This may just be a matter of perceptions needing to catch up to our new post-recession reality, where most CFOs no longer operate in silos, post hoc. While some finance executives have already embraced the increasingly connected C-suite model, others may still require some prodding to bring their insights to the table and try on new hats in the boardroom.

domain: finance


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A novel strain of swine influenza A H1N1 has already disseminated worldwide and has become a major clinical problem for intensive care units in selected areas. Many regions in the southern hemisphere are currently struggling to keep up with the influx of severely affected patients with acute respiratory failure from primary influenza pneumonia. The northern hemisphere is bracing for a similar surge of patients over this winter's influenza season. This initial report of ventilatory needs for patients with severe influenza pneumonia in Spanish intensive care units provides a useful guide of what to expect and how to respond to the challenge of pandemic influenza.
In the current issue of Critical Care, Rello and colleagues  describe their initial experience with severe swine influenza pneumonia in Spanish intensive care units (ICUs). The experience in Spain is similar to that reported from Mexico City  and the US , emphasizing an abrupt onset and severe hypoxemic illness, with acute respiratory failure developing often in young, previously healthy individuals (the median age in this study was 36 years). The World Health Organization declared swine flu a level 6 public health emergency soon after the emergence and worldwide spread of the influenza A/Mexico City/2009 (H1N1) virus . This novel swine influenza strain is highly transmissible person-to-person, although severe human disease occurs at low frequency. The currently estimated population mortality rate is 0.1%, but in the ICU patients reported in the study of Rello and colleagues , it is 18.8%. Although this virus lacks many of the features of the highly pathogenic influenza A H1N1 1918 strain [5-7] or the avian H5N1 strain [8,9], it could cause hundreds of thousands of deaths worldwide if an anticipated population attack rate of 10% to 50% is confirmed over the next year.
The influenza virus deploys a frontal attack strategy by rapidly invading the respiratory epithelium of susceptible individuals, where it induces diffuse necrosis, marked inflammatory changes, intra-alveolar hemorrhage, and a highly productive cough. The virus replicates exponentially in human cells and then is transmitted via respiratory aerosol to other susceptible human hosts. This process repeats itself throughout the human populations until such time as sufficient antibodies and perhaps other innate and acquired immune responses curtail further spread of the virus. The pathogenicity of this virus depends on rapid cleavage and activation of its primary attachment protein hemagglutinin (HA) and efficient release from cells by its neuraminidase enzyme . Other virulence factors, seen most prominently in the 1918 and avian H5N1 viruses, include polymerase basic-1 (PB1), PB2, and nonstructural 1 (NS1) proteins. The PB1-F2 protein primarily traffics influenza virus to the outer membrane of mitochondria, inducing cellular energy loss and eventual cell death [10,11]. The NS1 also promotes apoptosis and rapid loss of cell viability. Fortunately, the current swine flu pandemic strain lacks a number of these important virulence determinants . The virus is intrinsically resistant to amantadine and similar drugs but retains its susceptibility, for the most part, to the neuraminidase inhibitors oseltamivir and zanamivir. However, the risk of its developing oseltamivir resistance is real , and this demands caution against the profligate use of these anti-viral agents.
The current pandemic strain is a quadruple re-assortant virus with segments of its genome derived from Eurasian swine, North American swine, avian species, and human influenza virus strains. The HA from human-adapted strains binds primarily to sialic acids bound by alpha 2-6 linkages to galactose found on surface glycoproteins along the respiratory epithelium. Avian strains prefer alpha 2-3 binding sites, whereas swine influenza viruses usually bind to either alpha 2-3 or alpha 2-6 sialic acid-galactose linkages. This probably explains why swine are important as intermediate hosts for novel pandemic flu strains that periodically affect human populations .
In their report, Rello and colleagues  point out a disproportionately high frequency of severe pneumonia in pregnant women and obese patients. The risk of severe influenza in pregnant women during pandemics has been well known for decades . Less well characterized is the increased risk of severe influenza pneumonia in obese patients. This observation might not be mere coincidence; obese patients are more difficult to ventilate due to chest wall restriction, and adipocytes are immunologically active cells with fat tissue replete with macrophages . Adipose tissue generates proinflammatory cytokines and this may conspire with a systemic inflammatory response from influenza pneumonia to increase severity and mortality rates in obese patients. The events that have taken place in Spanish ICUs are likely to be repeated many times over in ICUs throughout the world.
Pandemic influenza generally occurs only once or twice during a professional career. How well, or how poorly, we respond as a global community will be judged for decades to come. How well prepared are we? Will the new H1N1 vaccines become available in time to protect susceptible human populations? Will supplies of anti-viral agents be sufficient and be equitably distributed throughout the world? The evidence so far suggests that there will be substantial shortfalls in supplies of both [10,11,16], and these shortfalls will likely cause severe difficulties in developing countries .
Could we use our current knowledge of the immunology and host response to influenza to devise an effective approach to help patients with severe pneumonia? The pathologic series of events leading to death from influenza likely has hereditary , environmental , and inflammatory [7,9] components. Is there too much inflammation in primary influenza pneumonia, or is there insufficient inflammation resulting in poor viral clearance? How many of the fatalities from influenza pneumonia are attributable to secondary bacterial pneumonia? Individual variation in the host response to influenza virus infection is probably an important determinant of ultimate outcome. Could we intelligently determine specific patient needs and intervene appropriately in severely afflicted patients?
A number of currently available agents on the market might provide some benefit in managing severe, primary, influenza pneumonia [10,11,20]. Would corticosteroid administration benefit selected patients or worsen viral shedding and mortality in severe influenza? Should we give immuno-adjuvants or immune suppressive agents in combination with anti-viral agents? These clinical questions need to be studied expeditiously and conclusively answered. Will we move forward together with a rapidly expanding, evidence-based approach to understanding influenza and its optimal management and be willing to share our knowledge and financial assets equitably between richer and poorer nations? As this pandemic evolves, the answers to these and other questions will become starkly evident within the next 12 months.
HA: hemagglutinin; ICU: intensive care unit; NS1: nonstructural 1; PB: polymerase basic.
The authors declare that they have no competing interests.
See related research by Rello et al., http://ccforum.com/content/13/5/R148

domain: biology


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Combine sugar and water and allow to dissolve. Add remaining ingredients and mix well. Serve cold or over ice.
Makes 4 (3/4-cup) servings, each containing approximately: 100 calories, 26 gm. carbohydrate, trace fat, 0 mg. cholesterol, trace protein, 7 mg. sodium, trace fiber
Thank you! your flag was submitted.

domain: food


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This Fred Bennett beaded leather bracelet features both sterling silver and black onyx beads to create a contrasing and stylish look. This piece would make a great addition to any jewellery collection and can be worn every day.
Fred Bennett Sterling Silver and Black Onyx Beaded Bracelet
£110.00 Regular Price
- Composition: This bracelet is made of leather and features black onyx and 925 sterling silver beads.
- Dimensions: black beads are 6.3mm and silver beads are 6.9mm
- Fitting: This bracelet is adjustable with a cord slide fitting
- Packaging: All Fred Bennett products will come complete with branded packaging.

domain: artistic


Well, I guess everything has to come to an end at some point. Today we had to take the Saturn in for some alarming noises coming from the engine block. I received the call later that day that the engine is toast. It would cost 4 times the value of the vehicle to replace the engine. So, dear Saturn… today, we part… you have been good to us… thank you.


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Barbara Walker first turned me on to knitting in her invaluable primer for beginners, "America's Knitting Book", now sadly out of print. Once you get past casting on and the basic knit and purl stitches, it's fun to start designing your own projects, and the "Treasury" makes this simple.
It was the "Treasury" that turned me into a dyed-in-the-wool "knitwit". It's mind-blowing to think that so many hundreds of patterns are varieties of just two fundamental stitches, the knit stitch and the purl stitch. Let your imagination loose; there's no limit on what you can make. The "Treasury" is organized into basic pattern groups, starting with simple knit-purl combinations, and advancing through ribbing, color-change patterns, slip stitch, twist stitch, and many more, all the way through lace and cable stitch patterns. The directions are very clear and concise, and the photographs are excellent. Walker doesn't give instructions for making different garments in this book, but she does explain how the patterns can be adapted to making just about anything.
One of the best (for this reviewer) chapters was the one on cable stitch knitting; here Walker tells how to design and make your own original fisherman's sweater, using any number of different cable stitch patterns. It sounded like so much fun that I decided to try it, and it came out so great that I promptly made another one, this time casting on from top to bottom and knitting the sweater sideways, so all the cables run horizontal. Talk about an original! This book really lets your creative genius loose. Use it, enjoy it, and have a lot of fun.


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'Love Birds' Personalised Gift Box
Our personalised 'Love birds' gift box is a beautiful collection of handmade gifts, perfect as an anniversary, engagement or wedding gift.
Packaged in a gorgeous box and personalised with your special message, this carefully thought out gift for couples is sure to delight.
We've carefully chosen a selection of luxurious, handmade items, including delicious handmade chocolates, a scented candle, relaxing bath salts and 'Mr & Mrs' shot glasses.
The bath salts are Lemon and calendula, great for relaxing together, the scented candle is dewberry and rosehip.
The gorgeous handmade chocolates can be shared then all that is needed is a shot of a favourite tipple to fill the glasses!
You can also personalise the front of the gift box with recipient's names, a special message and your name.
The gift comes perfectly packaged in a high quality kraft box with magnetic closure. The box is engraved with your message and has a laser cut paper wrap ready to send directly to the recipient.


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OR WAIT 15 SECS
© 2020 MJH Life Sciences and BioPharm International. All rights reserved.
© 2020 MJH Life Sciences™ and BioPharm International. All rights reserved.
October 26, 2020
Bayer will own the rights to AskBio’s AAV-based gene therapy platform, its intellectual property portfolio, and an established CDMO.
October 20, 2020
Orgenesis has completed its previously announced acquisition of Koligo Therapeutics with the additional acquisition of Tissue Genesis’ cell isolation technology, Icellator.
October 16, 2020
The new VirusExpress lentiviral production platform increases dose yields and reduces process development time for cell and gene therapies.
October 14, 2020
Roche will use Dyno’s CapsidMap platform to develop next-generation adeno-associated virus vectors for gene therapies for central nervous system diseases and liver-directed therapies.
October 01, 2020
The technology is a novel, plasmid-free manufacturing system for robust and reproducible manufacture of AAV at scale.
September 30, 2020
Cellnest will join Fujifilm Irvine Scientific’s PRIME-XV portfolio which consists of xeno-free and chemically defined media for stem cell culture.
September 14, 2020
The investment will include new manufacturing lines and increased automation to deliver additional manufacturing capacity.
September 10, 2020
The companies have signed an agreement for the production of two plasmids needed for the manufacture of CG01, a gene therapy for the treatment of drug-resistant focal epilepsy.
September 09, 2020
The company is investing $130 million to add Phase III through commercial-scale manufacturing suites to its gene therapy campus in Harmans, MD.
September 03, 2020
This article will explore the traditional path from the laboratory to the clinic and how the fixed-bed technology provides an alternative solution to meet commercial demands.

domain: medical


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Sweet Indulgences: Irresistible Chocolate Chip Cookies and Decadent Bread Pudding with Abevia Sweetened Condensed Milk
Indulge your sweet tooth with our delectable desserts that will transport you to a world of pure bliss. At Abevia, we believe that every bite should be a moment of pure delight, and that’s why we’re thrilled to bring you two irresistible recipes featuring Abevia Sweetened Condensed Milk. Get ready to satisfy your cravings with our mouthwatering Chocolate Chip Cookies and luscious Bread Pudding.
In our first video, we’re diving into the timeless classic – Chocolate Chip Cookies. Imagine sinking your teeth into warm, chewy cookies with pockets of gooey chocolate. Abevia Sweetened Condensed Milk adds a touch of sweetness and a soft, tender texture to these irresistible treats. Get ready to experience the ultimate chocolate chip cookie heaven!
Next up, we have a dessert that will melt your heart – Bread Pudding. This recipe takes humble bread and transforms it into a luxurious, indulgent delight. With Abevia Sweetened Condensed Milk, the bread soaks up the creamy sweetness, creating a velvety, custard-like texture that will leave you craving for more. Prepare to be enchanted by this heavenly dessert!
At Abevia, we understand that dessert time is the perfect opportunity to pamper yourself with sweet indulgences. Our Abevia Sweetened Condensed Milk is the secret ingredient that will elevate your desserts to a whole new level of deliciousness.
Whether you’re a fan of classic cookies or crave the comforting warmth of bread pudding, these two recipes – Chocolate Chip Cookies and Bread Pudding – are sure to satisfy your sweet cravings. Abevia Sweetened Condensed Milk adds the perfect amount of sweetness and creaminess to make these treats truly unforgettable.
So, preheat your ovens, gather your ingredients, and let’s create magic in the kitchen. Get ready to impress your loved ones with these divine, sweet creations. Join us in celebrating the joy of dessert and the irresistible sweetness of Abevia Sweetened Condensed Milk.


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The twenty-something songstress wrote most of her upcoming album, which will be released later this year.
“Dizzy is my album’s feel good, driving-on-the-beach-with-my-windows-down song,” Melanie told JJJ. “It was a blast to write and we channeled the old school Alanis [Morissette] that I grew up with jamming to, which I think came across well. It’s a song that came from my heart, so I hope everyone feels the love!”
Listen to Melanie‘s “Dizzy” below!


Outdoor burning ban extended because of continued dry conditions
Jon Dunaway, Fire Marshal
Phone: (360) 397-2186 ext. 3324
Vancouver, WA – The Clark County Fire Marshal is extending a countywide outdoor burning ban because persistent dry conditions continue to pose a fire danger.
The current ban on all land-clearing, yard debris and recreational fires on private land will remain in effect until at least mid-October.
Fire Marshal Jon Dunaway said the county’s ban, which was put in place in cooperation with Washington State Department of Natural Resources, could be revised if the region receives enough rain.
The ban does not extend to federally managed lands, although similar restrictions may be in place there.
The annual summer ban on land-clearing fires was expanded earlier this month to include recreational fires on private property. Recreational fires also are banned in the cities of Vancouver, Camas and Washougal as well as Cowlitz County.
The extended ban will help protect people, property and animals during unusually dry fall weather.
Dunaway will announce when the ban is lifted, but please check with the Fire Marshal’s Office at (360) 397-2186 before burning at your home.
Recreational campfires are only allowed in improved fire pits in officially designated campgrounds.
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A dental emergency is not unlike any other medical emergency. When one strikes, you need to know what steps you can take to improve your situation, and you need to know who you can turn to for help. With that in mind, Dr. Krunal Patel and Dr. Aditi Patel are both renowned emergency dentists who are committed to offering attentive treatment to patients from all across Palm Beach County.
Some of the most common dental emergencies include:
- Cracked or Fractured Tooth
- Broken Crown
- Tooth Loss
When you call us to report your emergency, we will offer valuable tips for managing your situation and help to schedule a time for you to come in immediately. We always do our best to provide patients with same-day service for an emergency. Follow all instructions and remain calm until you reach our office. If you have a more advanced dental emergency, or you cannot reach us, report to a nearby emergency room as soon as you can.

domain: health


Categorizing Halogen Bonding and other Noncovalent Interactions Involving Halogen AtomsActivity by Pierangelo Metrangolo | added on Mar 07, 2011 | Italy
Sponsor(s): IUPAC, CrystEngComm, Chem. Commun., Cryst. Growth Des.
The meeting “Categorizing Halogen Bonding and Other Noncovalent Interactions Involving Halogen Atoms” will be held in Sigüenza, Guadalajara, Spain on August 20-21, 2011, as a satellite event to the IUCr2011 (Madrid) and under the sponsorship of the IUPAC.
Halogen atoms in organic compounds typically can be found at the periphery of molecules. For this reason, they are ideally positioned to be involved in intermolecular interactions. For instance, halogen atoms are commonplace substituents in drugs and also occur naturally in biological systems, the best-known examples being probably the iodinated thyroid hormones, such as thyroxine. Indeed, interactions involving halogen atoms are frequently observed in protein-ligand complexes.
It is well-known that the electron density around the halogen nucleus is highly anisotropic so that halogens can serve both as electron-acceptors and -donors. The term halogen bonding has been introduced for describing any noncovalent interaction involving halogens as acceptors of electron density. The general scheme D···X-Y thus applies to halogen bonding (XB), wherein X is the halogen (Lewis acid, XB-donor), D is any electron-donor (Lewis base, XB-acceptor), and Y is carbon, halogen, nitrogen, etc. The definition itself sheds light on the nature of XB, which possesses numerous similarities with hydrogen bonding (HB), wherein hydrogen functions as the acceptor of electron density.
The objective of this meeting is to gather several international leaders in the field around the task of giving a modern definition of halogen bonding that takes into account all current experimental and theoretical pieces of information on both gaseous and condensed halogen-bonded systems in chemical and biological systems.
|Topic:||chemistry education, conferences||Audience:||students, professional chemists, professors, industrial chemists, research scientists, universities|


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Coming in November 2001!
AD CLOSING: September 17, 2001
MATERIALS DUE: September 24, 2001
BONUS DISTRIBUTION: LDI 2001 and BLMC 2001
Creating the dramatic and constantly changing looks of Madonna's Drowned World tour required a true commitment to teamwork from its designers, who include: production designer Bruce Rodgers/Tribe, lighting designer Peter Morse, video director Carol Dodds, sound designer Jake Davies and set engineer John McGraw. Participating vendors include: All Access Staging, Light & Sound Design, Clair Brothers Audio, Branam Rigging, Vari-Lite, Coemar, High End Systems, Nocturne, and Upstaging. Catherine McHugh reports.
DESIGNER ROUND TABLE: West Coast Lighting Designers
What happens when we bring seven of the country’s top lighting designers-Peter Maradudin, Trevor Norton, Anne Militello, Geoff Korf, Ted Ferreira, Karl Haas, and Tom Ruzika-together for dim sum in LA’s Chinatown? Plenty. Ferreira moderates this panel discussion covering topics ranging from unions to manufacturers to whether there really is a West Coast style.
100 Years of Disney Magic
It's Walt Disney's centennial year and Walt Disney World is celebrating with four new parades. At Disney-MGM Studios, "Disney Stars and Motor Cars" features the entire gang of characters riding in a series of outrageously customized cars. At the Magic Kingdom, "Share a Dream Come True" features a series of giant snow globes depicting Disney characters. Disney's Animal Kingdom comes alive with "Mickey's Jammin' Jungle" and the popular "Tapestry of Nations" parade is being reworked into "Tapestry of Dreams." David Barbour and Ellen Lampert-Greaux talk to the team members responsible for floats, costumes, and sound of these daytime park wide spectacles.
Cirque de la Mer
At Sea World of San Diego, a Busch-owned park, the new live show Cirque de la Mer is a highly stylized, colorful water pageant featuring acrobats, lush costumes, and evocative scenery. To house it, the old Bay Watch show at Sea World's lagoon was re-themed as the Amphibitheater. The show is a joint production of Scenery West and Sam Trego Productions. Scenery West developed the storyline and characters with creative consultant Ryan Harmon. Director of Design for Scenery West was Jodi Roberdes. Judy Rubin reports.
The most unlikely musical to hit Broadway in years, Urinetown is a musical spoof about a future society in which you have to pay to pee. Scott Pask's environmental setting required extensive reworking of the Henry Miller Theatre; the costumes by Jonathan Bixby and Gregory A. Gale spoof several genres of musical theatre.
DESIGNER BUSINESS: Theme Park Recruiting
How do the major theme parks attract the designers and technicians who work on their projects? A lot of it is through major recruitment efforts at trade shows. John Calhoun looks at the ways Disney and Universal recruit talent for their projects, and talks to designers who’ve gone through the process.
TECHNOLOGY: LDI2001 Product Preview
Our new technical editor Michael Eddy gives you a sneak peek at the Top Ten products to look for on the show floor in Orlando.
A chat with Phil O’Donnell, president of Strand USA.
TALES FROM THE HISTORY PROJECT:
John Tedesco of Phoebus Lighting.
Contact your ED sales managers for exclusive online marketing opportunities!
Visit our media center to view our rates for web advertising.
Deadlines for web ads:
October: September 15, 2001
November: October 15, 2001
Eastern Sales Manager: Aimee Eckert
212-229-2965 ext. 801 / Fax 212-229-2084
International Sales Manager: Adrienne Gurman
212-229-2965 ext. 814 / Fax 913-514-3614
Western Sales Manager: Holly O'Hair
909-694-8839 / Fax 909-695-4490
Classified Advertising: Melissa Pollitt
212-229-2965 ext. 817 / Fax 913-514-3627
32 West 18th Street
New York, NY 10011
A PRIMEDIA Business Magazines & Media Publication
Lighting Dimensions International /November 2-4, 2001/Orlando, Florida
Broadway Lighting Master Classes, Dec. 5-9, 2001/New York
Broadway Sound Master Classes, Dec. 6-9, 2001/New York
EDDY Awards, December 7, 2001/New York

domain: entertainment


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Whether they perform the procedure on themselves or have someone else do it for them, South African women who resort to illegal abortion typically use sharp objects, such as knitting needles, or harsh chemicals, such as chlorides (sold as “Clorox” in the United States). Every year, 300,000 of South Africa’s twenty million women undergo illegal abortions. They constitute about one in twenty-three fertile women. Many tens of thousands of the clandestine, unsterile operations result in infection or uncontrollable bleeding for the woman. The lucky ones receive life-saving medical attention, which often includes the removal of their septic abdominal organs. Others live, but suffer permanent medical trauma. The unluckiest ones die-l,500 to 3,000 every year.’ The discriminatory, interrelated forces that lead women to such fearful methods coalesce in South Africa’s abortion ban, which is still in effect after the April 1994 free elections.
Despite the staggering proportions of the phenomenon, the church in South Africa has turned a blind eye and a mute tongue. What are the theological implications of that silence? How is the church called to respond to the medical fallout from South Africa’s abortion ban? To follow its own tenets, what must the church do in the face of a law that, though it causes such anguish, was justified by the apartheid government in terms of Christian principles? In this Article, I argue that it is theologically imperative for the church to end its silence on several issues: the abortion ban, the apartheid government’s use of Christianity to justify the ban, the ban’s effect on women’s lives, and the church’s own tacit but powerful role in relegating women’s well-being to the bottom of the heap of theological and political values. In ending its own silence, the church will also cease its enforcement of the silence with which so many South Africans continue to have illegal abortions.


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French Wealth Management
Accepting new clients
Kenny French Sr, CEPA®
Stephen Koch, Associate Financial Advisor
Email a message
1501 E Mockingbird Ln Ste 102
Victoria, TX 77904
1 2019 –2021, and 2023 Barron’s Top 1,200 Financial Advisors, published in February or March each year, data as of September of the previous year. Compensation provided for using, not obtaining, the rating.
2 2022–2023 Forbes Best-In-State Wealth Advisors in Texas, published 1st quarter each year, research by SHOOK Research LLC, data as of June of prior year. Compensation provided for using, not obtaining, the rating.


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Lunasin-Enriched Soy Extract (LunaRich XTM), in Combination with the Dietary Supplement Reliv Now, Reduces Free Fatty Acid by Increasing Plasma Leptin and Adiponectin Levels in LDL-Receptor Mutant Pigs
Alfredo F. Galvez1*, Hosea Matel1, Jan Ivey2 and Doug Bowles2
1Missouri Plant Science Center and 2University of Missouri, Columbia
Elevated levels of free fatty acids (FFA) are associated with obesity and insulin resistance and can lead to diabetes, metabolic syndrome and cardiovascular disease. Daily supplementation using 500 mg of lunasin-enriched soy extract (LES) and one serving (18.3 gm) of the dietary supplement Reliv Now® has been found to significantly reduce FFA levels by 74% and 65% after 4 and 6 weeks, respectively, on obese LDL-receptor mutant (Rapacz) pigs. The decrease in FFA levels can be explained by the coordinate increase in plasma levels of leptin by 52% and 64% and adiponectin by 20% and 60% after 4 and 6 weeks, respectively. The decrease in FFA and the increase in leptin and adiponectin correlates with slower weight gain in the obese pigs. Removal of LES and Reliv Now supplements from the basic diet of the pigs increases FFA and decreases leptin and adiponectin to the baseline, unsupplemented levels. These results suggest that supplementation with LES and Reliv Now has the potential to reduce FFA and increase leptin and adiponectin levels, which are associated with preventing obesity and insulin resistance and the related disease modalities arising from these health conditions. However, human clinical trials are needed to validate these preliminary results.
According to the US Centers for Disease Control (CDC), there is a rising trend in obesity levels today with a parallel increase in type 2 diabetes. Elevated levels of free fatty acids (FFA) have been associated with insulin resistance in obese patients  and can increase inflammation . Insulin resistance and pro-inflammatory response are clinically important because they can lead to several diseases like type 2 diabetes, hypertension and cardiovascular disease . Although there is a close association of obesity, insulin resistance and type 2 diabetes to elevated FFA levels, there is a lack of effective treatments to lower free fatty acids .
Lunasin is a bioactive component in soy with a novel chromatin-binding property and epigenetic effects on gene expression [4, 5]. The soy peptide is heat stable, water soluble and found in significant amounts in select soy protein preparations . It can get inside mammalian epithelial cells through its RGD cell adhesion motif, bind preferentially to deacetylated histones and inhibit histone H3 and H4 acetylation . There is growing evidence that responses to dietary and environmental effects involve epigenetic changes in gene expression, which are modulated by the reversible processes of DNA methylation-demethylation and histone acetylation-deacetylation [7, 8].
Lunasin has been shown to have an anti-mitotic effect when expressed inside mammalian cells  and prevents cancer formation when applied exogenously in cell culture and in mice skin cancer model . The lunasin peptide has also been shown to have anti-inflammatory  and anti-oxidant effects , to improve innate immunity (unpublished results), and to prevent metastasis of colon cancer cells to the liver . The multiple health effects of the lunasin soy peptide have been attributed to its ability to bind to chromatin and affect gene expression associated with cellular health . The elucidation of its mechanism of action makes lunasin an important molecule for research studies to understand the emerging role of diet on epigenetic mechanisms that can impact the development of chronic diseases, such as obesity, diabetes and metabolic syndrome.
We have previously shown the effect of lunasin-enriched soy extract in lowering LDL cholesterol  and we now report a novel effect of the lunasin-enriched soy extract in combination with a soy- based dietary supplement, Reliv Now, on a supplement feeding study using a LDL-receptor mutant pig model . Reliv Now contains optimal blend of vitamins, minerals and herbal agents and is primarily used to lower risk factors for cardiovascular disease. Our study shows that supplementation with lunasin in combination with Reliv Now leads to a significant decrease in free fatty acid levels and the coordinated increase of leptin and adiponectin plasma levels in LDL-receptor mutant pigs
MATERIALS AND METHODS
We chose the Rapacz pig model  to test the biological effect of the lunasin-enriched soy extract (LES) extract on obesity, cardiovascular disease risk and metabolic syndrome because their weight and liver function are closer to humans than any other animal models. Also, the pigs have mutations to their LDL receptor gene that predispose them to high cholesterol, obesity and increased risk for heart disease . The 5 Rapacz pigs used for this study were approximately 1.5 years old and considered obese, weighing more than 20% from normal. The experiment was done with animal use permit at the Veterinary hospital at the University of Missouri, Columbia, MO.
In order to administer Reliv Now, the 18.3 gms powder was measured from a 29.6 cc scooper, mixed with 10 cc of water and formed into a dough ball that the pigs ate happily. The 500 mg dose of LES was selected based on previous study showing that 250 mg dose of LES was enough to reduce LDL cholesterol after 4 weeks in 1 -year old Rapacz pigs. We increased the dose to 500 mg to account for the increased weight of the pigs at the start of the study when they were 1.5 years of age. The 500 mg LES was put into two capsules of 250 mg each and was fed to the pigs by inserting them into a snack bar that the pigs like to eat.
To determine the bioavailability of lunasin after ingestion of 500 mg LES, we supplemented the diet of one pig with 500 mg LES and then blood draws were taken at 10 min, 30 min, 60 min and 24 hr after ingestion. The blood plasma was separated and the amount of lunasin was detected and quantitated by ELISA using a polyclonal lunasin antibody (Pacific BioLabs) and standard ELISA protocol.
To test the effects of the lunasin-enriched soy extract (LES) in combination with Reliv Now, we fed five Rapacz pigs daily with at least one kg of standard casein diet (BV233) and supplemented with 18.3 gm of Reliv Now and 500 mg of LES . The pigs were maintained on a soy-free diet (BV233 pig chow) throughout the treatment. Pigs were fed their regular diet (BV233) once per day in the morning at approximately 9:00 AM. Later in the afternoon, at approximately 4:00 PM, the Reliv Now and LES treatments were administered. Weight and blood draws were taken at pre-treatment (0), at 4 weeks, 6 weeks and 8 weeks after treatment had begun. At the end of 8 weeks, there was an additional 4 weeks washout period without treatment and weight and blood draws were also taken at the end of washout period (12 weeks). Blood draws were taken after an overnight fast (approximately 15h). Blood samples were tested for lipid panel including plasma levels of free fatty acids (FFA) by the Analytical Laboratory at the Veterinary School of the University of Missouri. Blood samples were collected into monoject tubes with 15% EDTA, centrifuged for 20 min at 3300 rpm to separate the blood plasma, which were transferred to 1 ml cryogenic vials and stored at -70oC to test for leptin and adiponectin levels. Plasma levels of leptin and adiponectin were determined using porcine leptin and adiponectin ELISA kits obtained from USCN Life Sciences, Inc. (Houston, TX USA). Standard protocols from the manufacturer were followed, including the use of 3 replicate measurements for each data point, to detect and quantify the amounts of leptin and adiponectin in the plasma.
Before conducting the supplementation study, we first determined whether lunasin can be detected in the blood plasma of a Rapacz pig at different time points after ingesting a 500 mg dose of lunasin-enriched soy extract (LES). Figure 1 shows that lunasin can be detected from the blood plasma as early as 10 min after ingestion and increased significantly after 30 and 60 min before peaking at 24h after ingestion. The total amount of lunasin detected in blood plasma after 24h was approximately 0.11 mg (Fig.1), which indicates that lunasin becomes bioavailable after ingestion of 500 mg LES.


Square D QOM2E2200NRB QO 200 Amp Enclosed Circuit Breaker
by Square D
See a problem? Report errors and help us improve our listings.
- 2-1/2 in maximum B-type hub on the top and a 2 in maximum knockout on the bottom
- Includes a PKOGTA-2 ground bar kit, B-hubs not included
- QO 200 A outdoor circuit breaker enclosure with QOM2200VH circuit breaker included
- Surface mountable for easy installation
- Type-3R enclosure for outdoor use
See similar products in our QO Square D Schneider Distribution Equipment department.
Shipping: This item is available for shipping to the US (Territories and APO/FPO) and Canada.
|Manufacturer Part Number||QOM2E2200NRB|
|Shipping Weight||18.19 pounds|
|Product Type||Circuit Breakers|


The A7 is closed in the Scottish Borders because of flooding.
Police are warning of heavy traffic in the area.The flooding is between between B6362 Townfoot / Station Road at Stow and Buckholm Mill Brae at Galashiels. Police are directing traffic.
More top news
Windy and colder. Rain or showers - some of which will be wintry on hills with some snow settling over highest ground. Some sunshine around
The Carlisle United Trust has voted overwhelmingly in favour of proposals to bring a £1.26 million investment to the club.
Cumbria Police has defended its decision to spend one £1.8 million on replacing traditional notebooks with new electronic devices.


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The Heavy Hauler Mini Duck Call Key chain is just what every waterfowler needs. The braided design in olive drab comes with a miniature duck call and a life size duck band. That duck call won't be far when the
If you are a duck hunter, you need one of these banded duck leg key chains. What better way to dress up your key ring and show that you a duck hunter. Key ring is attached to an orange duck leg with silver duck
Ducks Unlimited Mallard Duck Keychain makes a great gift idea for the duck lovers in your family. This keychain features a Zinc alloy die cut Ducks Unlimited logo and a 28mm diameter ring. Keep track of your keys
Costa Del Mar Logo Lanyard is a sturdy lanyard that measures 1 x 36 inches with a swivel snap hook. Features the Costa Del Mar wordmark and
This is such a fun gift and super way to show your love of RNT products. The RNT Hemp and Cocobolo Keychain looks just like a little RNT duck call with a couple of cute duck bands on each end and some trendy
Honk Quack Band MPW Mini Lanyard Keychain makes a great gift for the waterfowler at heart. Featuring the MPW logo, these waterfowl-themed keychains are made from paracord in the
Keep track of your keys and show off your preference for outdoors gear with the Browning Buckmark Keychain. Made of a durable metal alloy, this handy keychain provides an easy way for you to show off the
Show your passion for waterfowl hunting with this classic Heritage Pewter Mallard Flask Key Chain. This tiny flask key chain features a beautifully detailed 3-D sculpted mallard in flight in fine pewter.


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This attraction is well worth visiting, the mountains are not dangerous very shocking, I have been to many attractions, the price-performance ratio can be compared with the Tongtianxia not much, I hope everyone to go to see it fast.
Really good looking, I have been to several scenic spots in the past few days, Tongtianxia is the most beautiful and worth going, the scenery is charming, it is beautiful to go anywhere, not tired at all up the mountain, all the way, all the way to take pictures, cable car round-trip, there is a tour bus to go down the mountain, the package 180 is especially suitable, Look at the pictures I took. I recommend everyone.
Shanxi Tongtianxia scenic spot is beautiful, mountains around the water, the reflection of the lake, waterfalls, peaks and streams, vegetation, the air is fresh, summer scenery like Jiuzhaigou, beautiful, winter like Iceland, the ice wall hanging high, the scenery is chic. The scenic spot is located in Pingshun County, Shanxi Province, the scenic spot has the mountains of Zhangjiajie and the water of Jiuzhaigou, when in the scenic spot, look out, the waterfall scene under the flowing is grand, grand; When the boats are traveling through the lake, like a glacier, there is a feeling of being in the water, it is refreshing. Tongtianxia scenic area can be played all the year round, whether spring, summer and autumn and winter, the scenery here is variable, different, now this season, the scenery is more unique. Located in the scenic area, Pinghu, cruise ship, cable car, canyon, everything, waterfall spring pool everywhere, lake green, the two sides of the mountain peaks like knife chop, the unique scenery, worth the visit.
Tongtianxia, across the junction of Shanxi and Henan provinces, 50 kilometers west of Changzhi City, Shangdang Ancient City, north and red tourist resorts Eight Road Army Cultural Park and Taihang Water Township and other scenic areas, south Linzhou City, 35 kilometers, with the Slate Rock Scenic Area, Linxishan scenic area and the famous red flag canal connected.
Tongtianxia Scenic Area is a large canyon with the Hongtiguan and Dongsitou as its axis. It combines the Xiong, Qi, Dan and Xiu together. It integrates historical culture and natural scenery. It has four special areas: Grand Canyon, Xianren Peak, Hongxiu Waterfall and Hongti Ancient Pass. It is a small jiuzhai in the north----"Three mountains and five mountains Hui Taihang, Beixiong Nanxiu see smooth", Qifeng stands, thick, Taiji Stonehenge, nature and naturalization, the valleys are thousands of feet, the walls are thousands of feet, the waterfalls are flowing, like silver practice, Lin Xiu Tan You, birds and flowers, show in the forest, full of green eyes, green mountains, the weather is thousands of thousands, The humanities are gathering together, the magnificent mountains and rivers!
The scenery is infinitely beautiful, the scenery is beautiful and very good.
Tongtianxia has been to three times, the Grand Canyon can be called the northern small Jiuzhai, in the cliffs and axes, the mountains and rocks, such as the silver waterfall, the deep pool of blue waves, the four seasons of the scenery, all visitors linger.
The scenery and climate of Tongtianxia Scenic Area are beautiful and pleasant