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Backpage.com, now notorious for being a site frequently used to facilitate prostitution, was a target of current vice-presidential candidate Kamala Harris when she was the attorney general of California.
However – and despite her belief that it should be eliminated – she was not responsible for shutting the website down. Instead, she brought charges against Backpage’s executives. Even though many of the charges Harris’ office brought to Backpage executives did not result in convictions, she helped raise the profile of the website’s activities, which had been particularly active in San Francisco and other metropolitan hubs across the U.S.
Eventually, a Department of Justice inquiry led the website to get shut down. Here’s the full story of Harris’ pursuit of Backpage.
What Was Backpage?
Backpage was a classified ads website that offered all sorts of services; however, it began expanding after Craigslist.com eliminated its “Adult Services” section in 2010 after receiving a statement from 17 states’ attorney generals alleging that the section was aiding illegal exploitation, prostitution and human trafficking, as ABC News reported.
Ads featuring adult prostitutes were constantly being posted, for which Backpage collected a fee. Some anti-sex trafficking advocates also noted that teenagers were also posting ads; even after Backpage closed its “Adult Services” section, the Washington Post reported that many of the ads simply migrated to the website’s “Dating” category.
The Post reported that Backpage’s executives had maintained that they regularly took down illegal ads, reported violators the police and were not in any way involved in prostitution. The website also cited its rights not to be prosecuted under the Communications Decency Act, which provided legal immunity for websites if third parties were discovered to be using their website for illegal purposes and the website operators were not actively helping or deliberately ignoring the illegal activity. Furthermore, insisted that they would not be forced to engage in censorship.
Moreover, more investigations showed that Backpage was not as innocent in the website’s function as a facilitator of prostitution.
In 2017, the Senate produced a report showing that website employees had been rewriting prostitution ads clearly written by people who were underage and deleting references to their age:
In 2012, for example, Ferrer stated, “Many of these banned terms [e.g. first time, pure, innocent, school girl, etc.] are stripped out or banned so users can just modify their postings.” Backpage also worked directly with users whose ads were rejected or whose text was deleted. This direct contact with users — much like the automatic filtering process — was also successful in helping users post “clean” content despite the illegality of the underlying transactions. According to a December 2010 email written from
“firstname.lastname@example.org” to Ferrer, roughly “75% of the users we contact are converted to compliant.”
A Washington Post inquiry also revealed that Backpage employees in the Phillippines were actively reaching out to prostitutes to encourage them to use Backpage for their business.
How Did Harris Help Take Backpage Down?
In October of 2016, then-California Attorney General Kamala Harris announced that one Backpage executive and two shareholders were being charged with multiple sex crimes. Carl Ferrer, the CEO of online advertising for the site was charged with felony “pimping a minor, pimping and conspiracy to commit pimping” while controlling shareholders Michael Lacey and James Larkin were charged with felony “conspiracy to commit pimping.”
In the release, it was alleged that Backpage was “essentially operating as an online brothel” and that 99% of the company’s worldwide income came from the site’s adult section from users who post escort ads. The DA’s office also referenced the National Center for Missing and Exploited Children (NCMEC), who noted that 2,900 of suspected child trafficking incidents reported to California police since 2012 were related to Backpage.
Harris was also quoted in the release, saying:
Raking in millions of dollars from the trafficking and exploitation of vulnerable victims is outrageous, despicable and illegal. Backpage and its executives purposefully and unlawfully designed Backpage to be the world’s top online brothel. Thank you to the California Department of Justice Special Agents, investigators, attorneys, and our partners in law enforcement who have worked tirelessly to bring the operators of this online brothel to justice and protect thousands of victims of trafficking.
When that effort as dismissed, The Mercury News reported that Harris did not give up, instead, charging the three with 26 counts of money laundering and more sex crimes, including 13 counts of pimping and conspiracy. “My office will not turn a blind eye to this criminal behavior simply because the defendants are exploiting and pimping victims on the internet rather than on a street corner,” Harris alleged, noting that seven of the victims from the pimping charges were children.
The sex crimes were dismissed, while the money laundering charges stuck and in 2017, Ferrer eventually shut down the adult section of Backpage, Reason reported. Throughout the entire legal process, the three denied any allegations of promoting/profiting from sex crimes and accused Harris, who was running for U.S. Senate, of going after them to improve her chances at the polls.
On April 5, however, Ferrer pleaded guilty to one count of money laundering and one count of “knowingly conspiring to facilitate prostitution,” and began cooperating with the Department of Justice in a new set of charges being brought against Lacey, Larkin and other Backpage executives (Scott Spear, executive vice president; John Brunst, chief financial officer; Dan Hyer, a sales and marketing director; Andrew Padilla, operations manager; Jaala Vaught, an assistant operations manager).
Backpage was eventually shut down by the Department of Justice in April of 2018.
Harris’ Pursuit of Backpage Alienated Sex Workers
Some sex worker advocates saw Harris’ pursuit of Backpage as part of a pattern she had as a prosecutor: pursuing the criminalization of prostitution in an effort to end sex trafficking without realizing – or caring – about the impact on voluntary sex workers.
“It basically forced me back into much more dangerous forms of sex work, including soliciting clients on unconventional platforms, like Grindr, that aren’t intended for erotic services,” West Seegmiller, a former sex worker and current advocate for sex workers, told Los Angeles Magazine.
In California, Harris was often seen as antagonistic towards sex workers, the New York Times reported, in part because she failed to support Proposition K; the proposition sought to decriminalize prostitution, which some advocates said would protect those who are victims of abuse but are afraid to come forward because they are prostitutes.
When Harris was the district attorney of San Francisco in 2008, she was not in favor of the proposition, according to what she told the Times, “I think it’s completely ridiculous, just in case there’s any ambiguity about my position,” Harris said. “It would put a welcome mat out for pimps and prostitutes to come on into San Francisco.”
“We’re in the practice and habit of protecting victims, not criminalizing victims,” Harris said. “Our penal code was not created just to protect Snow White,” she said. The Times added that 65% of the victims in her department’s sexual assault unit were sex workers.
However, Harris appeared to have changed her position on that, telling The Root that she was open to the decriminalization of sex work in a 2019 interview.


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Not only did May contain Mother’s Day and Memorial Day Weekend, but also my birthday and my mother’s birthday. I had lot of time with family and lots of time in the car (thank goodness I don’t get carsick reading). There was some good weather and some bad weather – but all weather is good reading weather, right?
Below are some links I found and loved this past month, as well as my favorite / least favorite reads of this past month.
Links I Love
People Who Read Are Nicer, Study Finds: It is no secret that studies show that people who read has an impact on their emotional intelligence. But I love that this link was shared in a book discussion group on Facebook prefaced as, “This explains why everyone is so kind and generous.” 🙂
The Glass Castle Trailer: The trailer for Jeannette Walls’ The Glass Castle is now out! I will definitely be rereading this book before the movie comes out! How about you?
The Handmaid’s Tale: I actually got a request to read The Handmaid’s Tale. This has been getting lots of attention due to the newly released movie. I struggle with getting through classics but I think it is a worthy challenge for next month!
50 Inspiring Quote from 5 Levels of Leadership: Ahh, John Maxwell. 5 Levels of Leadership is a book you should read over and over again. But if you only have a few minutes, this is a great article with quotes straight from the book!
On The Blog
Wow, what a great reading month! (You can click on the links to read the full reviews!)
Title – Court of Thorns and Roses (Website, Goodreads)
Author – Sarah J. Maas (Website, Goodreads)
Published – May 5th 2015
Genre – Young Adult Fantasy
Summary – When nineteen-year-old huntress Feyre kills a wolf in the woods, a beast-like creature arrives to demand retribution for it. Dragged to a treacherous magical land she only knows about from legends, Feyre discovers that her captor is not an animal, but Tamlin—one of the lethal, immortal faeries who once ruled their world.
As she dwells on his estate, her feelings for Tamlin transform from icy hostility into a fiery passion that burns through every lie and warning she’s been told about the beautiful, dangerous world of the Fae. But an ancient, wicked shadow grows over the faerie lands, and Feyre must find a way to stop it . . . or doom Tamlin—and his world—forever.
Summary – Even before she made a name for herself on the silver screen starring in films like Pitch Perfect, Up in the Air, Twilight, and Into the Woods, Anna Kendrick was unusually small, weird, and “10 percent defiant.”
At the ripe age of thirteen, she had already resolved to “keep the crazy inside my head where it belonged. Forever. But here’s the thing about crazy: It. Wants. Out.” In Scrappy Little Nobody, she invites readers inside her brain, sharing extraordinary and charmingly ordinary stories with candor and winningly wry observations.
With her razor-sharp wit, Anna recounts the absurdities she’s experienced on her way to and from the heart of pop culture as only she can—from her unusual path to the performing arts (Vanilla Ice and baggy neon pants may have played a role) to her double life as a middle-school student who also starred on Broadway to her initial “dating experiments” (including only liking boys who didn’t like her back) to reviewing a binder full of butt doubles to her struggle to live like an adult woman instead of a perpetual “man-child.”
Enter Anna’s world and follow her rise from “scrappy little nobody” to somebody who dazzles on the stage, the screen, and now the page—with an electric, singular voice, at once familiar and surprising, sharp and sweet, funny and serious (well, not that serious)
Summary – From Dancing with the Stars runner-up and Duck Dynasty star Sadie Robertson comes a fun novel about two teenage girls from different backgrounds and opposite lifestyles who discover there is more to friendship than what meets the eye.
Sixteen-year-old A.J. Stewart, born and raised in backwoods Tennessee, loves nothing more than repairing broken cars with her father and hanging out with her brothers and their friends. Not far away in the busy city of Nashville, Kate Kelly is always dressed in the latest fashion, wearing clothes from her mother’s boutique and jetting around the world with her father.
When A.J. starts going to the school Kate attends, they instantly dislike each other. But as the year progresses, Kate’s brother Val is drawn to A.J., and when prom comes around, he asks her to be his date—much to his sister’s displeasure.
The following summer at camp, the two girls continue their dislike of each other, until a surprising moment of openness when A.J. shares her faith with Kate. As their bond grows, they discover that they share an inner resolve to live life as God intended, and to live it in their own individual and original ways.
In Life Just Got Real Sadie Robertson inspires teens to find the value God has placed inside us all and to live with confidence and purpose in a very complicated world.
Summary – Just when Glennon Doyle Melton was beginning to feel she had it all figured out—three happy children, a doting spouse, and a writing career so successful that her first book catapulted to the top of the New York Times bestseller list—her husband revealed his infidelity and she was forced to realize that nothing was as it seemed. A recovering alcoholic and bulimic, Glennon found that rock bottom was a familiar place. In the midst of crisis, she knew to hold on to what she discovered in recovery: that her deepest pain has always held within it an invitation to a richer life.
Summary – It is the last season of high school life for Nadia Turner, a rebellious, grief-stricken, seventeen-year-old beauty. Mourning her own mother’s recent suicide, she takes up with the local pastor’s son. Luke Sheppard is twenty-one, a former football star whose injury has reduced him to waiting tables at a diner. They are young; it’s not serious. But the pregnancy that results from this teen romance–and the subsequent cover-up–will have an impact that goes far beyond their youth. As Nadia hides her secret from everyone, including Aubrey, her God-fearing best friend, the years move quickly. Soon, Nadia, Luke, and Aubrey are full-fledged adults and still living in debt to the choices they made that one seaside summer, caught in a love triangle they must carefully maneuver, and dogged by the constant, nagging question: What if they had chosen differently? The possibilities of the road not taken are a relentless haunt.

domain: library


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Acanthosis nigricans (AN) is a common skin disorder characterized by abnormal differentiation and hyperproliferation of keratinocytes in the epidermis and structural changes in the dermis. We hypothesize that the AN phenotype results from inappropriate stimulation of several different growth factors receptors expressed in keratinocytes and fibroblasts (eg IGFR, EGFR and FGFRs) which normally function to direct epidermal differentiation and regeneration. We propose to use AN as a model to better understand the regulation of keratinocyte proliferation and differentiation by growth factor receptor signaling. This will be accomplished by: 1.) using immunohistochemical and in situ hybridization techniques to characterize alterations in the expression of differentiation specific keratinocyte genes in skin biopsies of different types of AN; 2.) assessing alterations in growth parameters and gene expression in cultured keratinocytes, melanocytes and fibroblasts expressing endogenous or transfected FGFR mutations; and 3.) attempting to recapitulate the AN phenotype in a skin equivalent organ culture model using either keratinocytes and fibroblasts expressing FGFR mutations or by manipulation of growth factors in the culture media. These studies will provide a better understanding of how various growth factor receptor signaling pathways influence keratinocyte proliferation and differentiation pathways and should provide insights into wound healing and other disorders of abnormal keratinocyte proliferation and differentiation such as psoriasis, sebhorreic keratoses and skin cancer.
|Bellus, G A; Spector, E B; Speiser, P W et al. (2000) Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype. Am J Hum Genet 67:1411-21|
|McIntosh, I; Bellus, G A; Jab, E W (2000) The pleiotropic effects of fibroblast growth factor receptors in mammalian development. Cell Struct Funct 25:85-96|

domain: medical


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Today is National Feral Cat Day, a day revered by cat rescuers across the country.
National Feral Cat Day was established by Alley Cay Allies in 2001 to raise awareness about feral cats, to promote Trap-Neuter-Return (TNR), and to recognize the millions of compassionate Americans who care for feral cats.
The promotion has evolved into a month long event with rescue groups in communities across the country holding hundreds of events to draw attention to the cause and make a difference in the lives of outdoor cats and the communities they live in.
About Alley Cat Allies
Alley Cat Allies is the national advocate for stray and feral cats. They are the foremost authority on TNR, a humane method of care that improves the lives of cats living outdoors.
In the 20 years they have been in existence, they have established and promoted standards of care and have brought humane treatment of cats into the national spotlight. These concepts are now embraced by major cities and animal protection organizations across America.
With TNR, outdoor cats are humanely trapped and brought to a veterinarian to be evaluated, spayed or neutered, and vaccinated.
Cats that have undergone the procedure are ear tipped for easy identification. In ear tipping, while the cat is under anesthesia a small portion of the left ear is painlessly removed.
TNR improves the lives of cats and stabilizes cat populations by ending the cycle of breeding. It also ends the stresses and behaviors associated with mating, such as yowling and fighting, making the cats better neighbors.
TNR is recognized throughout the United States and other countries as the humane and responsible way to care for feral cats.
What is a feral cat?
The fact is that there are no native feral cats. They are a species bred by people who do not spay and neuter their cats and kittens. Un-spayed and un-neutered cats and kittens are abandoned or lost and they meet up with other un-spayed and un-neutered cats and give birth to more kittens.
Thus “feral” cats are the “wild” offspring of domestic cats. Feral cat “colonies” can be found behind shopping areas or businesses, in alleys, parks, abandoned buildings, and rural areas. These cats are elusive and do not trust humans.
Studies have proven that TNR is the single most successful method of stabilizing and maintaining healthy feral cat colonies with the least possible cost to local governments and residents, while providing the best life for the animals themselves.
The voice of TNR in San Diego
The Feral Cat Coalition (FCC) of San Diego was established in 1992 by Sally Mackler and Rochelle Brinton, DVM. The FCC is an organization that traps and spays/neuters feral cats, then returns them to their caretakers at a rate of over 2,000 cats per year.
This service is provided to the community at no cost by licensed veterinarians and volunteers with one goal in mind: reducing the enormous number of homeless, unwanted cats.
Since their inception, San Diego Animal Control has seen a 50% decrease in the number of cats impounded and killed. Prior to the formation of the FCC, the number was increasing at a rate of 15% per year.
What you can do
One of the most important things you can do is to spay and neuter your own cats and kittens and tell your family and friends to do the same.
For your community, become a volunteer with FCC or with a local cat rescue group.
If you know of someone caring for stray, unowned cats, let them know about TNR and FCC.
Spread the word and encourage other cat lovers to become involved.
Visit the FCC website for other ways you can become involved and make a difference in the lives of homeless cats and kittens.


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domain: hobby


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Many natural foods and supplements can be added to your dog's diet that may provide some relief from the pain of arthritis. Diet becomes especially important.
Not only is there no benefit, but we saw a very consistent signal of harm,” said one study leader, Dr. Mandeep Mehra, a heart.
Dedicated volunteer rescue groups have dozens of animals in their care just waiting for forever families like you to adopt.
Some foods branded as beneficial for arthritic dogs may still contain fillers and.
you make a few modifications to how you give treats, especially for arthritic dogs.
cost can add up quickly – especially if you have a large dog or multiple dogs.
But dogs have been darlings of the screen since film’s beginnings, says Robin Ganzert, author of Animal Stars and president.
It was very emotional,” said Chief Vincent Alfano about retired police dog Dax’s final ride with his handler Sgt. Chris Alberini on Friday.
Hoffman Haus Pet Resort, in Winterville got permission to reopen to give essential.
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3.Is there any online tutorial or book that deals with displaying multi plane
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The 2016 tax season is in full swing and Riverside County Community Action Partnership’s Volunteer Income Tax Preparation (VITA) program is available to help qualifying residents file their taxes.
Facts and other information about the potentially fatal Ebola virus are available on a new web page from Riverside County health officials.
County Administration Center
4080 Lemon St. Riverside, CA 92501
Phone: (951) 955-1000
TTY Users: 711


Citizens’ inadequate access to information from public bodies undermining participatory democracy: Experts
Enactment and implementation of public access to information legal and policy frameworks, and protection of fundamental freedoms is a collective effort that rests with state and non-state actors, however, implementation of the right is still dependent on a well oil state bureaucratic machine. Increased active citizenship is pushing for Access To Information outside of the contours of formal access. States need to evolve and adapt new ways of information disclosure.
Despite the existence of laws and regulations on the promotion of knowledge societies in Eastern African countries aimed at unlocking essential rights to access to information and freedom of expression, the adoption and implementation of access to information instruments is still wanting which according to experts has sabotaged participatory democracy, individual dignity and denied citizen from enjoying other rights.
Experts from African Union, The United Nations Educational, Scientific and Cultural Organization (UNESCO), African Freedom of Information Centre (AFIC), University of Witwatersrand, Johannesburg among others who are participating in a 3 day virtual meeting on the promotion of knowledge society policy in National Information Policies for stakeholders from Eastern Africa from 17th August to 19th August 2021, expressed the importance of access to information and how its critical in enabling citizens to exercise their voice, to effectively monitor and hold government to account, and to enter into informed dialogue about decisions which affect their lives and empowering all citizens, including vulnerable and excluded people, to claim their broader rights and entitlements.
The theme of the workshop is “Building knowledge societies to ensure public access to information and protect fundamental freedoms, in accordance with national legislation and international agreements.”
In his opening remarks Executive Director, Africa Freedom of Information Centre (AFIC) Gilbert Sendugwa in picture above, told the participants that though the Eastern Africa countries have enacted various laws for the rights of access of information to citizens, there still exist gaps in the implementation urging the reaming 5 countries in the region which don’t have the provision for it to embrace the regulation.
“The East African region has over time made strides in enacting laws that guarantee citizens’ right of access to information, with seven laws adopted in Uganda, Kenya, Tanzania, Rwanda, South Sudan, Ethiopia and Seychelles albeit with gaps in implementation. Five countries including Djibouti, Eritrea, Comoros, Madagascar, and Mauritius remain without formal provisions for the right of access to information” he said
He added that in order address the rights to information challenges and realize implementation of the other SDGs, there is need for a multi-stakeholder action that he is optimistic will make efforts to achieve a leveled, sub-regional platform for dialogue between civil society, political and opinion leaders on access to information, an adequate mechanisms to facilitate disclosure of timely and accurate information proactively and reactively and build citizens’ ability influence policies and actions among others.
AmbassadorSalah S. Hammad (PhD), the head of the African Governance Architecture, Secretariat of the African Union (AU) pictured above from Africa Union (AU) during his speech to the virtual workshop urged all countries in the Eastern Africa region to embed the Access to information and fundamental freedom of expression rights in the laws and reserve it for the citizens whom he said will uphold democracy and lead to realization of other rights as stated in the Charter of the Africa Union.
While speaking to the participants, Prof. Hurbert Gijzen, Regional Director and Representative, UNESCO Regional Office for Eastern Africa said advocating for access to information and knowledge is necessary to advance society and protect the fundamental human rights which he added is also a mandate of the United Nation system while monitoring the implementation of the policies on access to information globally.
He above applauded those Eastern African countries that have contributed to the development of knowledgeable societies through harnessing the value of information but urged others countries to follow suit and integrate the 4 pillars UNESCO believes will feed the growing new opportunities.
“UNESCO will be happy to support other countries to build capacity to come on board to develop programs on access to information. National Information policies should integrate the pillars of Freedom of expression, universal access to information, responsibility for culture and linguistics, and quality education for all societies” he said.


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Osun State Government has announced the appointment of Prince Olayemi Yekinni Omisore and Prince Rafiu Oyekanmi Mosobalaje as Olu of Awolowo Town and Olupo of Oluponna respectively.
Recall that the stool of Olu of Awolowo in Ife South West Local Council Development Area of the State became vacant on 5th January 2022 following the demise of Oba David Olajide Omisore.
The stool of Olupo of Oluponna in Ayedire South Local Council Development Area also became vacant on 4th January 2022 following the demise of Oba Emmanuel Oyeleso Oyebamiji, Fadare II.
In a statement signed by the Commissioner for Information and Civic Orientation, Mrs Funke Egbemode, after the State Executive Council meeting on Monday, the state government said the succession to the stools of Awolowo and Oluponna towns followed the 2021 registered Chieftaincy Declaration and 2007 registered Chieftaincy Declaration respectively.
According to the statement, the appointment of Prince Olayemi Yekinni Omisore as the Olu of Awolowo-elect followed his emergence as the sole candidate at the meetings of the Kingmaker on 24th August 2022.
In the same vein, Prince Rafiu Oyekanmi Mosobalaje’s appointment as Olupo-elect followed a unanimous vote in his favour during a meeting of the Kingmakers on 30th August, 2022.
The two appointments take immediate effect.
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domain: politics


Military officers in Gabon seized power on Wednesday, putting President Ali Bongo under house arrest, shortly after the Central African state's election body announced he had won a third term.
Nicolas van de Walle is a professor of government with special focus on the democratization of Africa; and the politics of economic reform. He notes the coup is surprising given that Gabon has been a stable civilian dictatorship since independence, with firm control over the military.
Van de Walle says:
“Will this coup undermine the progression of democracy in Gabon? That seems unclear at present. The Bongo family stranglehold on the country’s political institutions has hardly promoted democratic rule despite regular elections in recent years. It has been characterized by egregious corruption benefiting the ruling family, and remarkably little economic development for a country with substantial oil revenues.
“Still, the international community has unanimously condemned the coup. France has forcefully argued the military should return to the barracks and respect the results of the last election, which Ali Bongo officially won amidst allegations of massive fraud. On the other hand, the coup leaders have argued their action was motivated by their rejection of the last election as fraudulent, and many of the people protesting in the streets of Libreville seem to think the Coup advances the prospects for democracy.
“It will be important in the coming weeks for the international community to put pressure on the coup leaders to state clearly their commitment of a transition to elected civilian rule. If they do that, it is certainly possible that getting rid of the Bongo dictatorship will prove to be a step in the right direction.”


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We needed a friendly, flexible sitter and found that in Jessica. She was open to all of our instructions for our two dogs including some temporary restrictions when our puppy was spayed. She always sent pictures and feedback on the walks and was even considerate not to walk them too long and ensure they drank water when it was hot outside. Appreciate her professionalism and flexibility!
Jessica is great with dogs! She is fantastic at giving pups lots of care and attention but also knows when they need a little time to get used to her. She has watched my dogs many times and they absolutely love her!
Jessica is my granddaughter and I’ve been involved with her her whole life. She has always been a hard worker, self motivator and very responsible. She has always had pets and understands their needs. She is very much a dog lover and I think she would be a valuable asset to your company.
Experienced animal caretaker
I am looking take care of pets while I attend grad school this Fall. I have grown up with dogs - including labs, Golden Retrievers, and Rottweilers, that I have taken care of myself, besides the many other animals that I’ve had including cats and horses. I currently have a rescued pitbull that I trained myself, so I am great with dogs of all sizes and breeds. I am extremely responsible and careful with the ...


Stacey Solomon has left her female following feeling inspired after taking to Instagram to share a hilarious video pointing out all of her body “imperfections”.
The mum-of-two is currently on holiday with her family, however, she took the time to film the light-hearted clip in a bid to boost her fans’ confidence.
Posing in just a bikini, Stacey points out her “muffin top, saggy boobs and stretch marks” as she jiggles her body, joking that her saggy boobs mean that she doesn’t ever need a bag on holiday, as she can store things underneath them.
The Loose Women star also laughed that stretch marks provide her children with hours of fun as they can colour them in and that laying on the stone ground is made easier with a softer body.
Writing alongside the video, Stacey provided her 457,000 followers with even more confidence-boosting advice, sharing: “SHOUT OUT TO EVERYONE ON HOLIDAY WORRYING ABOUT HOW THEY LOOK! You’re all perfectly imperfect and unique and beautiful.
“I thought I’d make a little holiday video celebrating my society labelled ‘imperfections’ because actually I love them, they’re part of me, and they have their uses!
“I think if we can all show off our insecurities then we will all start realising NOBODY escapes the world of perfection that we are all under pressure to keep up with and everyone can sleep a little easier at night knowing everyone comes in different shapes sizes.
“We all have the same extra ordinary bits that are seen as ‘imperfections’ but they’re not, they all tell a story of who we are and why we are and where we are going!”
The star was quickly inundated with praise from her fans after sharing the video, with one writing: “You inspire me so much! Thank you for promoting natural beauty and body positivity.”
Others added: “Well done, every point spot on. We’re all beautiful and perfect.”
“Absolutely brilliant!! @staceysolomon keeping it real.”
“Thank you!! So refreshing to see someone who is genuine and naturally beautiful. True inspiration.”


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May 26, 2015
The Suffolk Craft Society 44th Aldeburgh Summer Exhibition is a bright, buzzing major six week event celebrating the very best of contemporary crafts, skillfully made by talented Suffolk craftmakers who continue to push the boundaries.
The Suffolk Craft Society 44th Aldeburgh Summer Exhibition is a bright, buzzing major six week event celebrating the very best of contemporary crafts, skillfully made by talented Suffolk craftmakers who continue to push the boundaries. The exhibition features a visual feast of original quality pieces, giving a real opportunity to shop for “not on the high street” items for that special gift or to appreciate in your own home.
There are handmade bags, brooches, cards and unframed prints for just a few pounds, to larger sums for unique furniture, framed prints and precious jewellery. You will also see amazing ceramics, glass and metal work, basket weaving and carvings - made to the exceptionally high standard demanded of the Society's members, many pieces having been made specifically for this flagship 44th Exhibition.
Member Dennis Hales works with locally grown sycamore, holly, ash and maple, the white woods offering a natural canvas for a wide range of finishing techniques. He uses turned, carved, textured surfaces, water soluble dyes and metal leaf to enhance the natural features of the wood.
His work includes fruit displays, sycamore bowls embellished with silver leaf and wall plates of ash with copper leaf.
Danielle Hopkinson is a designer of architectural stained glass whose work ranges from small inexpensive stars or birds to large murals and windows for public buildings and private houses.
The image shows one of her typical exhibition pieces, inspired by natural forms. Danielle is currently working on an exciting “big piece” to be revealed at the Aldeburgh Exhibition.
Venue: Peter Pears Gallery, 152 High Street, Aldeburgh IP15 5AQ
Open: 10am to 5pm daily
11th July to 24 August
Admission: £1 – children free
For further details:
Tel: 01473 432865 to 10 July then 01728 451503

domain: design


text:
5pm: A spell of late summer sun is forecast across the country this bank holiday weekend.
Most of the UK is set to be dry and bright for the three-day weekend – after weeks of wetter than usual weather for August, according to the Met Office.
High pressure is likely to dominate into the start of September, suggesting the settled spell could continue into next week.
Met Office spokesperson Grahame Madge said: ‘It will be a largely fine and settled weekend; there’s very little – if any – rain in the forecast.’
The best conditions can be expected in Northern Ireland and western Scotland on Saturday.
As the weekend progresses, the warmest temperatures are expected to be in southern England.
Mr Madge said conditions are expected to cool slightly going into Monday.
He added: ‘Although temperatures may come down a little bit, there should still be plenty of bright conditions and plenty of weather for people to enjoy over the bank holiday.’
Looking ahead into September, he said there has been a ‘fairly strong signal’ for conditions to be warmer than average, while rainfall levels are expected to be close to average.

domain: news


text:
Centro Storico – EN
Piazza del Popolo - Peoples' Square
Once, the square located further north of Rome has been for many centuries the gateway for almost all travelers, therefore one of the most important squares from the representative point of view. Rearranged almost entirely at the beginning of the nineteenth century, today it is the most modern square in the historic center, one of the many meeting places for young and old, street artists, and above all, Federico Fellini’s square of the “Dolce Vita”.
Mausoleum of Augustus
The family tomb of the first Roman emperor built at the end of the 1st century BC today is a ruin. Despite having been reused in different ways throughout its history, the typical shape of the Roman mausoleum can still be recognized at first glance.
Erected as a Roman temple in the 2nd century AD under the reign of the emperor Hadrian, it was soon reused as a Christian church, and it is also for this reason that today it is the most well-preserved Roman monument in the eternal city. It is one of the most spectacular monuments in the world, and is famous above all for its immense dome – up to the present day the largest ever built in Rome. The Pantheon still remains wrapped in mysteries for its construction to the greatest scholars of history and art.
Today Piazza Navona is known as the most beautiful square in Rome, both for its particular shape and its beautiful baroque fountains. However, in ancient times Piazza Navona was really a stadium which only over the centuries was transformed. But the traces of its origin can still be observed today in many details. In today’s Roman times, it is also a popular meeting point, and above all the place where the Befana festival is celebrated, a Roman festival dating back to the 10th-6th century BC.
The historic market square of Rome today is certainly one of the most famous and popular squares in the city even if it is one of the few that is not connected to any important monument. In the center of the square the statue of Giordano Bruno (Italian philosopher and monk, one of the first to be convinced of the truth of the Copernican solar system, for this he was sent to the stake) is located. The square has a wonderful atmosphere, and a little curiosity about Campo de ‘Fiori is the very different aura that you breathe in the morning, with the classic local market, and in the evening with the nightlife, appearing inexplicably, two completely different squares.
For many centuries the Jewish Ghetto of Rome, this area has kept its name to the present day – but not the atmosphere. Today it is a beautiful and very popular neighborhood, but at a closer look the gloomy history of this district is remembered in many details.
Teatro di Marcello
A typical Roman theater, built for the will of the emperor Augustus and dedicated to his nephew Marcellus. Today it is the best preserved ancient theatre in the city of Rome. During its history it was reused in the most varied ways, so that today a curious mixture between Roman and medieval architecture can be observed.
Once the seat of the Embassy of the Republic of Venice for the Papal States, today the “Venice Square” is dominated by the Monument to Vittorio Emanuele II. This monument, built between the late nineteenth and early twentieth century is one of the last imposing monuments erected in Rome before its historic center was declared a World Heritage Site by UNESCO in 1980.
Fontana di Trevi - Trevi Fountain
This immense eighteenth century fountain was built in the late Baroque style and is located at the end of an ancient Roman aqueduct. Both in size and beauty it is one of the most famous fountains in the world. The fountain is also well known today, for the famous bath of Anita Ekberg in the film “La Dolce Vita” by Federico Fellini. The Roman legend says that throwing a coin into the fountain will bring good luck, and that with absolute certainty, you will surely return to the eternal city. It is no coincidence that the Trevi Fountain collects more than one million Euros in coins every year.
Piazza di Spagna
This square, which once housed the Spanish embassy for the Papal States, is best known for its staircase, the ‘Spanish Steps’, that connects the square below to the church ‘Trinità dei Monti’ located above the staircase on the Pincian hill. At the foot of the stairs one of the most popular Roman fountains, the so-called “Barcaccia” is located, which was built in the 17th century by Pietro and Gian Lorenzo Bernini. Today, both square and stairs are among the most popular meeting places in the city, where friends meet, but also many encounters with tourists from all over the world take place. This is mainly thanks to the steps of the stairs from where you can not only enjoy a wonderful view, but until recently you could sit down for a short break and often spend the entire evening.

domain: history


text:
Restaurants near Ben Hill Griffin Stadium Gainesville, Florida
Came here on a Thursday for trivia with a bunch of friends and had a blast! Their specialty cocktails are great, and they have a wide selection of beer....
Great food. Great character. My wife and I enjoyed a delicious lunch there today. She had a turkey and cheddar cheese wrap that was incredible. The aioli...
Food Stands, Hawaiian
When their actually OPEN they definitely deserve more than 5 STARS! However, I do not have Facebook & it's hard to tell these days if they will actually be...
This was by far THE best restaurant I have been to in a long time! We went on April 12 for dinner. We had the clam soup. Thank God we ordered the bowl of...
Diners, Breakfast & Brunch, American (Traditional)
This place is GREAT! Excellent service and a decent sized menu. They even have 3-4 different types of Eggs Benedict! I ordered a meat omelette. It was...
Salad, Pizza, Fast Food
PSA: If you haven't been to blaze you're missing out!! They make your pizza similar to how they make your order at chipotle. Everything is right in front of...
After hearing about Embers from several people decided to drop in for a birthday celebration. Without a reservation we were seated fairly quickly. The...
Vegetariano, Sucos & Vitaminas, Vegan
This place is really as good as it gets; it's local, the food is fun, healthy, and the customer service is great. I struggle to make a decision on what to...
Coffee & Tea, Wine Bars
Curia is off the strip and is part of a little community of shops. There's actually two separate buildings for Curia, one is the coffee shop and the other...
Greek, Sandwiches, Mediterranean
I had bypassed this spot so many times and finally I made it a point to stop in, and I'm so glad I did! In a sort of strip mall alongside two other...
Mediterranean, Kosher, Vegan
One of a kind. Sababa is simply amazing. A family business delivering great food. A tiny restaurant overshadowed by the others in downtown, it is a flavor...
Coffee & Tea, Breakfast & Brunch
Bay Island always has the softest, freshest bagels and amazing coffee selection. It's hard for me to pick what I want most of the time! This is one of...
Cheesesteaks, Soup, Sandwiches
Dang, that sandwich is off the chain! The food is fantastic, the window staff very helpful and the the sandwiches are fantastic. If they only offered half...
Amazing vietnamese good! I had the Spicy Beef noodle soup and it was so delicious! The owners are very dedicated and give great service. Best vietnamese...
Whoever gives this place anything less than 5 stars because they're a princess about "decor" needs to chill. Yes, it's a dive. Yes, it's a hole in the wall....
Egyptian, Mediterranean, International Grocery
I LOVED THIS PLACE! The food was amazing, prices are cheap as heck, and the woman on the phone was super nice. I got in an accident and broke my foot, so my...
Burgers, Fast Food, Sandwiches
I think these are the best burgers in Gainesville and the chicken sandwiches are good also. Good food at a good price you won't be disappointed.
This place is my favorite late night go to. The pizza tastes great and the hours accommodate my constant cravings.
I'm finally glad I got to try this place out after being intrigued for many years. If you plan on staying for at least an hour with your friends, ordering a...
Cafes, Bakeries, Juice Bars & Smoothies
To be honest there aren't many places that only serve vegetarian dishes in Gainesville. And so I have high respect for the owner who opened this. The...

domain: food


text:
Scrapping 150 projects, Big Oil could become “structurally impaired”
HOUSTON — Blindsided by a brutal downturn, oil companies have scuttled plans for scores of costly energy projects in an industry-wide retreat that could wipe out 19 million barrels from the world’s daily regimen of hydrocarbons over the next few years, a new report says.
Oil companies have canceled or delayed final investment decisions on about 150 projects that are tied to 125 billion barrels of oil equivalent, which could stay underground for several years longer than expected amid a steep drop in crude prices, energy investment bank Tudor, Pickering, Holt & Co. said Tuesday.
“By not sanctioning projects today, you’re putting a hole in production in 2017, 2018 and 2019 — potentially a big hole,” said David Pursell, head of macro research at Houston energy investment bank Tudor, Pickering, Holt & Co.
Analysts had expected U.S. oil production, which is down by 500,000 barrels from its peak in April, to drop more rapidly than it has this year and help crude prices recover quickly from multi-year lows.
But one of the lessons of the year-long price slump has been that if crude prices stay low long enough, other sources of crude will have to share in the global output decline that’s expected to eventually put oil supply and demand back into balance. Outside of the 13-member Organization of Petroleum Exporting Countries, all kinds of crude production are at risk when Big Oil is forced to weigh investment returns against scenarios in which crude prices remain depressed for years.
The U.S. Energy Information Administration believes the harvest of liquid fuels in non-OPEC countries like Russia and the United States is going to sink in the fourth quarter of 2015, the first absolute decline since mid-2011. Non-OPEC production growth is expected to sink by 520,000 barrels a day — its lowest point next year — in the first quarter of 2016.
CONTINUE READING HERE.

domain: finance


text:
Queer and trans drawing class – Monday night 6 week class starts 8th November – Monday 13th Dec 6.30 – 8.30pm upstairs at Thistle Hall, Upper Cuba St Wellington
A queer and trans space for us to explore drawing . In my experience it can be a very powerful and liberating experience to represent ourselves and our communities, in our own ways. So I’d like to share this with you. Some of what we do will be expressive drawing, and some will be life drawing with a model.
“I’m just gonna throw out a few words to describe the things I felt and saw during this experience: Open, warm, messy, creative, friendly, beautiful, kindness, smiles, laughter, colourful, shadows, shade, smudgy, supportive, reflection, peaceful, consistent, eccentric, stillness, grounded, fulfilling, energy, accepted, pride, strength.” Feedback from participant
We will all have different levels of experience and resources to share, and my aim is that we learn from each other, and all hold the space together with generosity, care and compassion.We will learn lots about drawing together in this class, but it is also about process, being together, and creating community. You don’t have to be able to draw, or have ever drawn before. Mistakes, and trying things out are just as valuable as a ‘good drawing’.
Thanks to generous funding from Creative Communities through Wellington City Council, I have 7 free places for low and unwaged people to have a place – yay! 8 paid places, at $285 for the six weeks, all materials included.


Note: This article was first published on May 31, 2020, when Narendra Modi completed six years as prime minister of India. It was republished on October 7, 2020, when Modi entered into his 20th year as head of an elected government.
There are some facts which just do not admit any contradiction. For example:
– the Raj Kapoor-Nargis duet “Pyar Hua, Ikraar Hua…” in Shri 420 remains the most mesmerising romantic song of Hindi cinema;
– no woman, before and after, looked as bewitchingly beautiful as Madhubala did when she danced to that wonderful song of defiance – “Pyar Kiya To Darna Kya…” – in Mughal-e-Azam;
– No batsman, Indian or foreign, played the cover-drive with as exquisite an elegance as did Rahul Dravid; and,
– Narendra Modi is not only the greatest demagogue free India has produced, he is also the most powerful ruler India has known since Lord Curzon.
There’s no room for any doubt or contradiction. Jawaharlal Nehru, Indira Gandhi, Rajiv Gandhi, P.V. Narasimha Rao and certainly not Manmohan Singh – none have enjoyed the kind of complete and total ascendency that Narendra Modi exercises today in every power and constitutional equation.
Let us enumerate the elements of prime ministerial power in a parliamentary system like ours.
First and foremost: mastery over the cabinet. No prime minister was ever as much a master of his/her cabinet as is Narendra Modi. Nehru had to share power and authority with Sardar Patel; he had Maulana Azad who could tick him off; later, there was Govind Vallabh Pant, with a mind and weight of his own.
Indira Gandhi had to contend with Morarji Desai, and later had to defer to Jagjivan Ram and Y.B. Chavan. Still later, she had to deal respectfully with Kamalapati Tripathi, R. Venkataraman, etc.
Rajiv Gandhi allowed himself to be overshadowed by Arun Nehru. P.V. Narasimha Rao was never allowed his prime ministerial equanimity by Arjun Singh. Atal Bihari Vajpayee had L.K. Advani sniping at his heels. And, Manmohan Singh had Pranab Mukherjee and A.K. Antony as implacable cabinet colleagues.
In total contrast, Narendra Modi has not allowed any cabinet colleague to think that he or she could have a profile independent or different than countenanced by the PMO. The pretentious Sushma Swaraj was put in her place within six months. Rajnath Singh, the poor man, is permitted to feel that he is the senior most member of the cabinet, but that’s just it.
And, now with Arun Jaitely and Sushma Swaraj gone, there is not a single cabinet minister who can walk out and still hope to survive a week politically.
No prime minister was as complete a lord and master of his/her cabinet as is Narendra Modi.
There are two other political entities – the parliamentary party and the ruling party organisational establishment – which can clip a prime minister’s wings. Before Modi, all prime ministers had to submit and adjust themselves to the tricks and tantrums of the party ‘bosses’; and, all prime ministers had to ensure that the parliamentary flock remains pliant and peaceful.
On both these counts, Modi can afford to be supremely indifferent. And, as a BJP prime minister, he also has to attend to a particularly bothersome establishment based in Nagpur. Again, very deftly, those self-important men have been adequately sized up – and dealt with.
Then, there are constitutional institutions of restraint – a wise and watchful Rashtrapati Bhavan; a parliament exacting accountability; a vigilant judiciary calling out waywardness; an independent Election Commission, insisting on fair rules of the games – which have been put in place to ensure a certain kind of equilibrium of authority and power. The idea is to ensure that a prime minister does not become a runaway autocrat. But, again, with a disciplined sense of purpose, with considerable political deftness and sheer brazenness, Prime Minister Modi has reduced these institutions of restraint to mere encumbrances. In particular, Modi has been exceptionally brilliant in extracting compliance and timidity from the higher judiciary.
As prime minister, Modi has liberated the media of its institutional onus of ‘speaking truth to power’. No prime minister before has found himself/herself in the happy situation when the media goes after the opposition. Not to forget, no prime minister has ever found himself saddled with so determinedly leaderless an opposition as has Narendra Modi. A perfect prime minister.
Not just at home, Modi stands way above his democratic counterparts. Look at US President Donald Trump. The man has to explain himself week after week; he has to put up with a quarrelsome media and has to spar with detractors on social media. In India, increasingly, no one dare write an unfriendly tweet about the prime minister, lest he/she lands up in jail on charge of sedition. No one dare make an issue of the fact that he should address a press conference; unlike Trump, no questions about Modi’s policies or leadership are to be entertained.
There can be no doubt that today Narendra Modi is the world’s most powerful democratically elected leader; and this is a great blessing for India in these times of uncertainty and turbulence, with enemies – seen and unseen – lurking around the corner, out to distract this ancient land from our destiny. Now, we are told we should be applauding the fact that in just six years, he has undone achievements and accomplishments of six decades. Within six years, our derailed national journey to glory and greatness stands resumed.
It is only natural and logical that this most powerful prime minister should also emerge as the Total Ruler, who can find his rightful place in the company of great transformative leaders known to history. It is only natural that some mistakes be made. So what of it? History knows of no ruler who did not make mistakes. And, as the ancient wisdom goes, no omelette can be made without breaking a few or many or maybe a million eggs. Anyway, who is counting?
There is a certain relentlessness to the logic of a prime ministerial autocracy. And it is entirely logical that there should be disdain for any institution or individual questioning the Modi regime. The solicitor-general’s impatience with the apex court is entirely understandable. The honourable law minister is within his right to wonder why the choice of judges cannot be left to the prime minister “if he can be trusted with the country’s nuclear button”. And the other ministers are not wrong to suggest that some Congress leaders are weakening the nation’s resolve when they carpingly point out inadequacies in Modi government’s ‘war’ on the coronavirus.
Till the Nehruite liberals can find the imagination and the instrument to roll back our prime ministerial autocracy, we should count our blessings. We must be grateful for our bountiful leadership dividend.
No questions, please.


We have renamed Post Grid plugin to Post Grid Combo
Hey man great plugin and i'm going pro but i have questions.
- I cannot add shortcode that is provided by an other plugin, is that fixed after i update to pro?
2. Is it possible to add a 'save post' icon to save the users most favorite post to one page? (Saved Posts).....
3. When i put the premium version in my shopping cart, it automatically adds 2 times, i selected 1 domain. is that normal?
4. Can i change the domain later on? will everything be saved?
i hope we can make it work but great plugin!!
hey man i fixed it! i set fixed height to 100% with some padding in between post grid items.


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The Unexpected Truth About Mature
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Enable the staff understand you’re interested in starting an adult day care company and ask literature. Luckily, management of ADD in adults is never too late because there are still unique an adult could do in order to manage the signs. Determine where you will operate your mature specialneeds day-care enterprise.

domain: sociology


text: Most Internet services (e-commerce, search engines, etc.) suffer faults. Quickly detecting these faults can be the largest bottleneck in improving availability of the system. We present Pinpoint, a methodology for automatic fault detection in Internet services by (1) observing low-level, internal structural behaviors of the service; (2) modeling the majority behavior of the system as correct; and (3) detecting anomalies in these behaviors as possible symptoms of failures. Without requiring any a priori application-specific information, Pinpoint correctly detected 89-96% of major failures in our experiments, as compared to 20-70% detected by current application-generic techniques.

domain: literature


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text:
Sequencing data summary
In our study, libraries were constructed from liver tissue samples from ND-fed mice (n=5) and HFD-induced hepatic IR mice (n=5) and subjected to sequencing analysis. High-throughput sequencing produced 516,429,450 and 457,341,558 raw reads from the two groups, respectively. The raw reads were filtered to obtain high-quality clean reads. In total, 506,933,232 and 448,761,362 clean reads were retained for the ND and HFD groups, respectively (Table 1). The Q20 and Q30 of the clean data were subsequently calculated to evaluate the quality of the RNA-sequencing data. The Q20 and Q30 quality scores were higher than 90%, and the sequencing error rate was less than 1%. The data indicated that the RNA-sequencing results had reliable quality. The obtained clean reads were mapped to a mouse reference genome, with the mapping ratio ranging from 96.10% to 97.13% (supplemental file 2).
Identification and classification of lncRNAs in the liver of mice
Based on the mouse reference genome and related databases, 10,495 known lncRNAs were found. After a strict filtering process, 541 novel lncRNAs, which exhibited repeated emergence in four software programs (CPC, PfamScan, CPAT and CNCI), were identified (supplemental file 3). According to the relative chromosomal position of the coding gene, the novel lncRNAs were classified into five broad categories: 5,572 intergenic lncRNAs (50.5%), 4,004 antisense lncRNAs (36.3%), 642 sense exonic overlap lncRNAs (5.8%), 22 sense intronic overlap lncRNAs (0.2%) and 796 bidirectional lncRNAs (7.2%) (Figure 1A). Furthermore, the distributions of these lncRNAs in terms of length and chromosomal location were analyzed in this study. In different length groups, most of the lncRNAs were 201-1,000 nt long (Figure 1B). Chromosomal distribution analysis revealed that chromosomes 1, 2, 5 and Y contained relatively higher amounts of lncRNAs (Figure 1C).
Differential expression analysis of lncRNAs and mRNAs
After high-throughput sequencing, a total of 11,036 lncRNAs were obtained by comparing the ND and HFD groups. The analysis of the lncRNAs DE between the two groups showed that compared with the ND group, the HFD group contained 232 DE lncRNAs, among which 108 were upregulated lncRNAs and 124 were downregulated lncRNAs. Regarding the expression profiles of mRNAs, 40,675 mRNAs were present in both groups. Among all of these mRNAs, compared with the ND group, the HFD group contained 291 DE mRNAs, including 166 upregulated mRNAs and 125 downregulated mRNAs. A volcano plot and heatmap were generated to visualize the DE lncRNAs and DE mRNAs identified by comparing the two groups, as shown in Figure 2 and in supplemental file 4. Moreover, the chromosomal distributions of the DE lncRNAs and mRNAs are shown in Figure 3.
DE lncRNA validation by q-PCR
To validate the reliability of the lncRNA expression data, seven lncRNAs that exhibited relatively abundant expression and significant differential expression in the livers from mice in the two groups were selected and evaluated by q-PCR. These lncRNAs included one upregulated lncRNA (ENSMUST00000200707) and six downregulated lncRNAs (ENSMUST00000107095, ENSMUST00000146928, ENSMUST00000153523, MSTRG.7107.6, MSTRG.19471.1 and MSTRG.19772.3). The results showed that the level of the lncRNA ENSMUST000030200707 was significantly increased, while the levels of the lncRNAs ENSMUST00000107095, ENSMUST00000146928, ENSMUST00000153523, MSTRG.7107.6, MSTRG.19471.1 and MSTRG.19772.3 were obviously decreased in the HFD group compared with the ND group (Figure 4). The q-PCR validation results for these DE lncRNAs were consistent with our bioinformatic analysis based on high-throughput sequencing.
GO and KEGG enrichment analyses of target genes of the DE lncRNAs
First, target genes of the DE lncRNAs were predicted by bioinformatic approaches, and the results are presented in supplemental file 5. Subsequently, GO and KEGG enrichment analyses were performed on the predicted target genes of the DE lncRNAs. The top 30 GO terms are shown in Figure 5, in which “glycerol biosynthetic process from pyruvate” was majorly enriched in the biological process category. GO enrichment also indicated enrichment of other important biological processes, including various compounds and nucleic acid metabolism in the cell, mitochondrial modification, catalytic enzyme activity and molecular function regulation. Furthermore, the top 30 enriched KEGG pathways are presented in Figure 6, and the “Renin-angiotensin system” was the top enriched pathway. More importantly, pathway enrichment analysis showed enrichment of several pathways related to IR or glycolipid metabolism, such as the citrate cycle (TCA cycle), the PPAR signaling pathway, the AMPK signaling pathway, the MAPK signaling pathway, glycolysis/gluconeogenesis, the glucagon signaling pathway, biosynthesis of unsaturated fatty acids, the PI3K-Akt signaling pathway, insulin resistance, and the insulin signaling pathway.
Interaction and coexpression network analysis
The interactions among the proteins encoded by the DE mRNAs are shown in Figure 7A. The Cxcl2, Serpine1 and Prss2 genes were the important genes that interacted with many of the other DE mRNAs in this network. Moreover, a DE lncRNA-mRNA coexpression network, which consisted of 87 nodes (59 DE lncRNAs and 28 DE mRNAs) and 1,125 edges, was constructed (Figure 7B). Within this RNA network, the lncRNA MSTRG.8007.2 had the maximum number of targets. The Pnlip, Ctrl, Cpb1 and Amy2a3 genes had the maximum number of coexpressed lncRNAs.

domain: biology


text:
Fenmarc has been growing, preparing, packing and supplying potatoes and vegetables to major multiples and wholesale markets for over 40 years.
They started growing Rudolph potatoes, for which they have exclusive rights in the UK, as part of their continued commitment to drive the development of varieties that benefit the supply chain – from the grower to the customer.
Paul Foster, recently voted Young Chef of the Year by the Observer Food Monthly says "Rudolph potatoes are available all year round and are one of the most versatile potatoes I have ever used, with a fantastic flavour and texture"
"Rudolph has to be the most exciting potato that I have had the privilege to use for a very long time. It responds really well to whatever you do with it"

domain: agronomy


text:
If it’s been that kind of night and you’re looking for ways to sober up fast, let’s get one thing out of the way right off the bat: there is no scientifically proven way to speed up body processes when it comes to alcohol. The only hope you have when you’re drunk or hungover is time.
That doesn't stop people from embracing every common myth and miracle cure out there that promises a rapid alcohol detox. We get it — any port in a storm. Unfortunately, some of these “cures” can actually make you feel worse.
Let’s do some myth-busting on sobering up fast. Then we’ll cover how to handle a hangover and avoid getting too drunk next time.
7 Alleged Sobering Up Strategies
We’re calling these “alleged” strategies because we already gave you the bad news. Any level of alcohol consumption can mean feeling alcohol’s effects and a potential hangover the next day.
Some of these may help you treat your hangover, but they won’t do anything for how drunk you are in the moment.
1. Drinking Water
Alcohol can have a dehydrating effect. Water is great for hydration while you sip on alcoholic beverages. That’s about as far as it goes. Water won’t dilute anything that’s already in your system or reduce your blood alcohol level.
That said, it’s never a bad idea to have a glass of water in between each drink to slow down your drinking. It won’t affect the absorption of alcohol in your body, but it could keep you from drinking to excess.
2. Drinking Coffee
Coffee may give you a jolt of energy, but it won’t speed up the processes responsible for moving ethanol through your system. The same is true for any caffeine or drink boosts that make promises they can’t possibly keep.
Too much caffeine can be dehydrating, too, which definitely won’t help that morning after wine headache. If a cup of joe sounds really good after drinking too much, go for it. Just make sure to supplement with plenty of water to keep dehydration at bay until you’re 100% sober.
It’s a great idea to eat something before you start drinking alcohol so that you’re not drinking on an empty stomach. Shoot for complex carbs, healthy fats, and protein. You’ll slow down the absorption of alcohol that way and potentially reduce your risk of a bad hangover.
There really aren’t any foods that sober you up fast, though. Snacking on salty treats or chowing down on a greasy meal after the fact won’t do much good. In fact, all that grease and fat could irritate your stomach further and cause some uncomfortable bathroom escapades.
4. A Cold Shower
Cold showers are a popular sober-up trick in movies and TV shows, but they won’t do much other than perk you up in the short-term. You’ll still be just as drunk after you towel off as when you got into that cold shower.
We’d generally caution against any showers if you’re dealing with alcohol intoxication, by the way. You could slip and hurt yourself.
5. Sweating It Out
Your liver processes more than 90% of the alcohol in your system. For anyone who forgot basic anatomy, byproducts from your liver pass through your kidneys and bladder, and out of your body in urine. That means all that effort in the gym won’t help you sober up.
In fact, you’ll probably just feel worse. Working up a sweat will add to your fatigue and dehydration and make you feel more nauseated.
If you swear morning-after hot yoga sessions do wonders for your hangovers, we’re happy for you. It’s probably just a placebo, though. (So quit it with the peer pressure!)
6. Sleeping It Off
“Sleeping it off” isn’t really a thing, as much as “sleeping through it.” Time is the best way to get you back on your feet. It may feel like you achieved the impossible if you wake up feeling dandy after a night of drinking. It’s not magic, though. You’ve probably just let your body get the rest it needs to process the alcohol and recover.
Alcohol can impact sleep quality, so you may need to sleep longer than usual to feel rested.
How long does it take for alcohol to wear off? It can take up to 24 hours for alcohol effects to wear off, but most people start to feel better around the 8-hour mark.
It’s also important to note here that passing out after drinking can be dangerous. Excessive drinking can cause alcohol poisoning. It can slow your heart rate, dull key reflexes like your gag reflex, and cause seizures.
If you’re around someone who has been binge drinking, keep them upright or on their side and call 911 if you think they’re at risk of an alcohol overdose.
Need more long-term help? If you’re worried you or someone you know are at risk for an alcohol use disorder, seek out alcohol addiction centers or support groups:
- National Institute on Alcohol Abuse and Alcoholism (NIAAA) Alcohol Treatment Navigator
- Substance Abuse and Mental Health Services Administration or call 800-662-4357
- Alcoholics Anonymous
7. Throwing Up
As soon as that alcoholic drink hits your lips, it starts its journey toward your bloodstream. Throwing up doesn’t do anything for alcohol that’s already absorbed by the body. It won’t help you sober up, and throwing up regularly could damage your esophagus.
If you’re drunk and going to vomit anyway, it could help you feel better in the short-term — alcohol is toxic and your body knows it. However, you should never use self-induced vomiting to try to sober up.
So, is there a way to sober up fast?
There is no proven way to sober up fast. Time is your friend here. It’s unsafe to believe otherwise, especially if you’re trying to figure out how to sober up fast to drive. In that scenario, call a friend or a rideshare. Don’t put yourself at risk for getting pulled over for a DUI, or worse — drunk driving accounts for about a third of crash-related fatalities. Better safe than sorry.
Once you’re safely home, how much time you’ll need to sober up depends on your body.
How Your Body Processes Alcohol
Alcohol by definition is a depressant. Even in those without mental health concerns, it slows down bodily functions, including your metabolism. That can affect everything from your glucose metabolism to nutrient absorption.
Your body doesn’t digest alcohol like it does other things you consume. The alcohol has to metabolize, with a few stops along the way. Your bloodstream is first.
Heavy drinking in a short amount of time results in a higher blood alcohol content (BAC), or blood alcohol concentration, and more obvious side effects from alcohol. From there, alcohol impacts organs like your brain and the small intestine before making it to the liver.
Your liver does most of the heavy lifting when it comes to alcohol metabolism thanks to enzymes like alcohol dehydrogenase. Too much drinking over time doesn’t make your liver stronger, either. It can cause liver failure or conditions like fatty liver disease.
This metabolic process doesn’t work the same for everyone. Enzyme levels, hormonal fluctuations, and body mass all matter after any amount of alcohol intake. That’s why many women get drunk faster than men.
Medications, health conditions, how much you’ve had to drink, even whether you’ve been drinking on an empty stomach also matter.
What To Do Before Bed
What can I do to sober up overnight? To sober up overnight, get enough rest to give your body a chance to process the alcohol.
There is no quick fix for how to sober up fast before bed, but there are a few things you can do before you hit the hay to potentially reduce a bad hangover when you wake up.
- Drink a big glass of water. We keep talking about the dehydrating effects of alcohol use, but it really is the most common culprit behind bad hangover headaches and fatigue.
- Chug some electrolytes. If you know you’re going to throw up, electrolyte drinks like Gatorade or Pedialyte can help get you hydrated and feeling a little better.
- Eat a light snack. No, a slice of pepperoni pizza is not the best idea, no matter how good it sounds. If you’re feeling nauseous, a piece of toast can help settle an upset stomach.
- Take an anti-inflammatory for headache relief. Always take the recommended dose and avoid any over-the-counter pain relievers on an empty stomach.
- Do NOT mix alcohol with other medications like sleeping pills or antidepressants. If you’re worried about a prescription interacting with alcohol, talk to your healthcare provider.
Handling a Hangover
Waking up with a nasty hangover isn’t fun for anyone. While there aren’t any miracle hangover cures out there, there are ways to reduce the effects of those telltale signs of too much wine. We go into our favorite remedies in our guide to hangover relief, but here are a few simple tips:
- Hydrate with lots of water.
- Sip on tea or a little caffeine.
- Eat a light, nutritious breakfast.
- Try anti-inflammatories.
- Get plenty of rest.
From there, it’s really just a waiting game while the effects of alcohol work through your system.
How to Avoid Getting Drunk Next Time
Let’s say you’ve sort of learned your lesson with that last brutal hangover and want to be prepared for next time. There are ways to have a good time, keep things from getting out of control, and generally treat your body better.
- Don’t buy into hype. You know better now. There’s no easy fix for sobering up fast or tackling hangovers. Share that with friends who think otherwise.
- Eat something. Give your body a barrier to slow down alcohol absorption. Shoot for complex carbohydrates, protein, and healthy fats for a wellness boost while you’re at it.
- Drink less. The order you drink those drinks doesn’t matter but how much you drink does matter. Pay attention to standard drink sizes. A standard glass of wine is 5 oz, by the way.
- Skip the bubbles. Fizz in your drinks doesn’t matter nearly as much as quantity, but carbonation can get you feeling tipsy faster.
- Slow down. Sip, don’t chug. You need to give your body time to process the alcohol. Add a glass of water in between each drink if you’re having more than one.
- Avoid alcohol altogether. There are enough alcohol alternatives out there that it’s easy to say no alcohol if you don’t want to risk feeling like garbage the next day.
We’re not just talking about fun mocktails, either. If you love wine, dealcoholized wine like Surely non-alcoholic sparkling Brut is a great way to have it all. You’re still sipping on wine, since our products start out like conventional wine. You’re just cutting out the alcohol.
Try our bubbles in cans, if you want something that travels well!
- Coffee with High but Not Low Caffeine Content Augments Fluid and Electrolyte Excretion at Rest
- Interaction of carbohydrates with alcohol dehydrogenase: Effect on enzyme activity
- Alcohol in the body
- Overview: How Is Alcohol Metabolized by the Body?
- Low doses of alcohol substantially decrease glucose metabolism in the human brain


text:
Pearland is a city located in the U.S. state of Texas, within the Houston–The Woodlands-Sugar Land. According to the reports of a census done in 2010, the city’s population stood at 91,252. Pearland’s estimated population growth rate from 2000 to 2010 was 142 percent, which ranked Pearland as the 15th fastest growing city during that time period, corresponds to other cities of the U.S.
Pearland, one of the largest cities in the MSA in Houston and ranked as the fastest growing city in the MSA in Houston and the second most rapidly growing city in Texas from 2000 to 2010. If you wonder about its name, it was changed from Mark Belt to Pearland in November of 1893 because of the abundance of pear trees in the community.
The city, Pearland, got the 2019 Top Workplace Award. So, if you plan to shift to this land, then the decision is significant. As living in the territory of pears, one will surely have the desire to stay for long and have the unique structure of his/her house, and this can be attained by the best designers of the city. Yes! You got it right we, ‘Pearland Landscape Designs & Outdoor Living Areas’ gives the excellent dream work.
Let us now talk about your home where you will need kind of adornment soon or yet. We provide the best services of landscape designing and outdoor living spaces as well with superfine tools and equipment and well-trained staff. We use the magnificent and most unique items and designs. You can trust us because we work with this subject that the client’s house is like our house, where one person will not want any malfunction or deficiency.
We work balancing all the basic requirements of the customer i.e., time, budget, and quality. Our specialized services like deck installation, waterproofing of materials, polishing also come under applicable rates. Package benefits can be taken too that are given by us and can even customize them accord to your requirements.
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Further, we provide the maintenance service too. It mainly comprises trimming, replacement of the defected decorative materials, fertilizing, old grass removal, brush clearance, garden cleanliness, and much more. You can contact us for such issues at any time, and we will ensure that the service will be expedited.
Our company’s primary purpose is to design correctly in line, proportion, order, color, and texture to meet the needs and satisfaction of the customer. Our research clearly shows our quality. We think the combination of nature and modernity will lead to a miracle.
You are simply one call away to make your house a delightful place to live in; we ‘Pearland Landscape Designs And Outdoor Living Areas’ company will make your colorful dreams come to reality. Our services have been stated below: –
- Grass installation
- Various landscape designing
- Outdoor living space decoration
- Deck painting and installation
- Gardening and cleanliness
- Maintenance services
Our Features: –
- Equipment & Crew for Any Size/Type Job
- Ownership of vehicle fleet and equipment
- Work Completes On-time and Budget
- Fully Licensed
- Insured and Certified
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Our brand comes out as number one when looking for lawn services in Pearland. Our company offers the best solutions and no other brand can beat us. You will get all these high-end services at affordable rates. The crew has a love for vegetation and you can be sure that we will give you the best. Most of the beautiful lawns that you see in the city are the work of our hands. You can get the same in your compound by requesting for a free quotation from our company. The team is more than ready and willing to serve you. Here is a list of the services that we offer to our esteemed customers;
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We service all of Texas. Below is a list of cities most of our services are at on a daily basis:
And all other cities throughout Texas, just fill out the form below for a free quote!

domain: geography