text:
Technical Report, pp.1-83, 2019
he immune system is a set of complex and dynamic mechanisms, that protects the
body against pathogens and maintain homeostatic balance in the presence of an
internal disruption. Besides its protective roles against pathogens, the immune system
is intertwined with the large scale systems such as the nervous system and different
types of metabolic systems and constitutes a variety of sophisticated multi-
dimensional mechanisms ranging from antibody production to tissue remodeling.
The immune system consists of two distint categories; innate immunity and adaptive
immunity which are interrelated. The innate immunity is much more rapid and
abundant whereas the adaptive immunity develops specific responses upon
encountering a pathogen in concert with the innate immunity. Additionally, the
adaptive immunity generates a memory mechanism to fight off the pathogens that have
already been encountered.
Innate immune responses are generally regulated by conserved yet limited set of
Pattern Recognition Receptors (PRRs). PRRs contain two types of receptors:
membrane bound and cytosolic receptors. While Toll-like receptors (TLRs) and C-
type lectin receptors (CLRs) are considered membrane bound, NOD-like receptors
(NLRs) and RIG-I-like receptors (RLR) are considered cytoplasmic PRRs. This thesis
involves a comprehensive set of experimental studies designed to deepen the
knowledge of NLRC4 and its activation through TLRs.
Members of the TLR family are transmembrane receptors that have critical roles in
promoting rapid and diverse pro-inflammatory responses. For instance, TLR2
recognizes microbial glycolipids and lipopeptides whereas TLR 4 recognizes
lipopolysaccharides. TLR 5, another surface TLR, recognizes bacterial flagella.
Activation of TLR signaling pathways result in the expression of a broad range of pro-
inflammatory cytokines and receptors such as IL-1, IL-6, IL-12, IL-18 and CD80,
NLRs are cytosolic PRRs that are induced by molecular patterns of pathogens or
damage associated molecular patterns (DAMPs). The NLR family consists of 22
members in humans. NLRs consist of three main domains: a C-terminal LRR domain
that sense microbial molecules or danger associated molecules, a central NACHT
domain that mediates NLR oligomerization and an N-terminal domain which activates
NLRP3 is probably the most studied and well-characterized member of the NLR
family. As a member of the NLRP subfamily, NLRP3 constitutes a PYRIN domain
and inflammasome assembly upon ligand recognition by NLRP3 requires the adaptor
protein ASC. NLRC4, on the other hand, does not have a PYRIN domain and can form
inflammasome with or without the interaction with the adaptor protein ASC. Uponxx
activation, both of the members of the NLR family are reported to form protein
complexes known as inflammasomes and this activation results in cleavage and
secretion of the cytokines IL-18 and IL-1β into their biologically active forms.
Eosinophils play critical roles in the defence againts extracellular parasites and in the
development of allergic responses. Since they develop extensive inflammatory
responses, eosinophils are not abundant in the human blood, only constituting 1-6% of
all white blood cells. And even though NLRC4 and NLRP3 are well-studied in other
contexts and white blood cells, their roles in shaping the eosinophilic functions are
Since eosinophils are sparse in the human blood, we used the human eosinophilic
leukemia cell line EoL-1 which provides a model for the investigation of eosinophilic
functions. To characterize the functions of PRRs in general and NLRs in particular,
we first analyzed the expression levels of NLRC4 and NLRP3 and the expression of
eosinophilic markers at both mRNA and protein level.
We have observed that in the eosinophil like EoL-1 cells, NLRC4 and NLRP3 are
expressed both at mRNA and protein levels. We have also observed that NLRC4
mRNA and protein levels are augmented upon induction with two signals, signal 1
being the TLR ligand and signal 2 being the NLRC4 ligand, transfected flagella.
Moreover, our western blotting results demonstrated that in EoL-1 cells NLRC4 and
NLRP3 inflammasomes were activated and caspase-1 and IL-1β are cleaved into their
active forms in EoL-1 cells upon induction with NLRC4 and NLRP3 ligands. Our
ELISA results also displayed that EoL-1 cells secreted the cytokine IL-1β at 24 hour
NLRC4 poststimulation and 10 hour NLRP3 poststimulation. EoL-1 cells also secreted
the inflammasome independent cytokine IL-6 upon TLR4 induction but stimulation
with flagella alone without transfection did not cause any IL-6 secretion in these cells.
Of note, 40% NLRC4 knockdown was sufficient to detect both biologically and
statistically meaningful decline in the secretion of IL-1β.
Furthermore, we verified that EoL-1 cells display a number of specific characteristics
of human eosinophils. They express IL-5 receptor IL-5Rα which takes part in the
survival and activation of eosinophils and the allergy related IgE low affinity receptor
FcεR2 which is expressed on eosinophils. Additionally, EoL-1 cells expressed the high
affinity Fc epsilon receptor FcεR1α and the immunoregulatory Siglec-8 protein upon
induction. Hence, it is safe to say that EoL-1 cells provide a good model for the
investigation of eosinophilic functions.
There are studies underlying the effects of PRRs on eosinophilic functions and their
involvement and relationship with the Th2 responses. In the light of this study, we
have shown the positive effects of NLR and TLR induction in promoting the
eosinophilic functions. PAM3CSK4 (TLR2 agonist) stimulation and flagella
transfection both significantly elevated the number of EoL-1 cells expressing the
eosinophilic marker IL-5Rα and low affinity Fc epsilon receptor FcεR2. Additionally,
NLRC4 activation led to an increase in the high affinity Fc epsilon receptor FcεR1α
and Siglec-8 expressing cells. Nevertheless, NLRP3 or TLR5 induction had no impact
on the expression of the above mentioned receptors.
Because eosinophils respond in extensive measures to infections or allergens, their
proliferation must be tightly regulated and limited. The functional roles of the surface
receptor IL-5Rα is of great importance in the survival of the eosinophils and their
activation. We observed a reciprocal relationship between NLRC4 and the IL-5Rα.
EoL-1 cells expressed higher levels of NLRC4 protein when cells were stimulated withxxi
IL-5 as compared to non-stimulated cells. Interestingly, percentage of IL-5Rα
expressing EoL-1 cells were higher in cells that are stimulated with PAM3CSK4 and
flagella than cells stimulated with PAM3CSK4 alone.
A few studies reported the antigen presenting capabilities of eosinophils upon
activation. Our flow cytometry results suggest that non-treated EoL-1 cells expressed
CD80 and CD86. Stimulation of cells via NLRP3 and NLRC4 axis with TLR2 agonist
caused an increase in the number of CD80 expressing cells and ATP treatment and
flagella transfection even further increased this effect.
On the basis of current data, NLRC4 could be deduced to be more closely related to
allergic responses while TLR signaling promotes more general, global immune
responses in EoL-1 cells. Taken together, our findings present potential targets for both
the further characterization of eosinophilic functions and allergic responses coupled
with a new frame of thoughts to understand the relationship between PRRs and

domain: biology


text:
Al Masah Capital Management began in 2010 and quickly rose as a prominent player in Middle Eastern and North African investing. The team focused on Alternative Investments in communities where this was a rarity.
It was more than an investment. It was a cooperative team of focused individuals who can offer depth expertise and consistent returns with a powerful and unique vision for success. The team does not let investments sit. They work for the clients, maximizing returns and offering a personal relationship along the way.
A Personal Portfolio
The intimate and personal aspects of portfolio management are often lost in the pursuit of numbers. The team offers both. Clients obtain rich results, but the portfolios are customized to meet their expectations, demands, and personal strategies of the clients. In other words, it is a philosophy of understanding. The only way to breach the often impersonal world of investing is to listen, learn, and engage.
The Basics of Portfolio Construction
Of course, the construction is based purely on the numbers. The core of portfolio construction opens with a technical analysis platform and a fundamental valuation of the core returns. The portfolio provides a list of roughly 200 different exchanges or stocks weighing market weight, turnover, history, and a number of other market inclusions. From this comprehensive list is provided a top matching stock list. These are about 20 stocks that promise superior results and the closest matching based on the algorithm.
The team applies two basic techniques. The first is a specific line match to the valuation model. This is sometimes too specific and alienating. The second approach is to match to underweight/overweight/neutral rationale returns.
The above is technical. The approach to client needs is specific and curated to their own desires in the marketplace. The goal is to construct a portfolio that is personal and captivating for the client.
It is more than a match-the-numbers affair. This is especially important in alternative marketplaces in non-global spanning markets, such as South Africa and the Middle East. These markets require delicate care and personal understanding. The team provides the best possible experience and results in markets still growing into their own.

domain: finance


Forever the blueprint for a sturdy foundation of a South Park episode was Cartman championing something he doesn’t quite understand. And 9.9 out of 10 times he’d rally behind a cause or movement to his twisted advantage. I’m talking about crack babies and KFC, somali pirates, The Passion of the Christ (though he might have stayed on Mel Gibson’s message for that one), and putting Butters’ little slapstick in his mouth to prove he’s not gay. The list goes on and on, but we’re not here to pop member berries even if this is the show’s 20th season. The question that “Weiners Out” asks is, what happens when Cartman doesn’t try to game the system in a self-serving way?
There may be way more going on behind the scenes than the first four episodes indicate, but right now Cartman is positioned as the reluctant hero, something we never thought would happen in South Park. We know Cartman isn’t SkankHunt42. He has a girlfriend and possibly has seen a vagina, meaning he now fully understands that girls don’t have balls, proving that they’re so much more than ball-less creatures that occupy the other side of the playground. He thinks girls are funny. Hell, did you see the new Ghostbusters? Kate McKinnon! When Amy Schumer talks about her vagina, I lose my fucking mind, too. Cartman, swept away in the feminist movement, is effectively out of the game. He’ll return, as is foreshadowed in the closing moments of the episode, but that leaves a massive hole in South Park. When one butthole is taken out of the limelight, another rises in his place.
The cost of letting Cartman run his mouth for 20 seasons is an army of minions getting riled up in his absence over… guess what… something they don’t understand. The girls are fed up with the boys’ (really Gerald’s trolling) behavior, and the boys are pushing back on the grounds that they shouldn’t be shamed for their gender. In South Park’s most on point social satire of the season, you get an angry Butters poking his little slapstick ding dong out of his pants and raising his fist in solidarity with his male brethren.
Remember last season when everything got PC in a hurry? The un-PC movement is back, and PC Principal is sitting in his office in a PC pretzel. In a masterful way, this is Matt and Trey again showing how two sides try to manipulate the rules to win an argument. The girls are mad at the boys for their protest and want repercussions, yet PC Principal allowed their volleyball protest in episode one. It would be unfair for PC Principal to disallow the boys their freedom of expression, even if they’re flopping more weiners than a George R.R. Martin adaptation. And can we really be body-shaming little boys? See, a fucking PC Pretzel.
All of this remains a product of Gerald’s sick obsession with trolling. He’s on the cusp of anonymity for now, but the “watching porn on the internet” defense is only going to end in more splashes of Sheila’s golden stream in his potty mouth. A worthy punishment for a filthy troll.
With Cartman out of commission, we’re left with dangling weiners, popped member berries, and desperate trolls. Don’t you dare fault Gerald, Butters, Heidi Turner, or the snake in the grass feminist girls. Never forget that this is still Eric Cartman’s South Park, one we’ve been building up to for decades.
Super School News Extras
– “It was just stupid, harmless locker room humor… until that lady killed herself.”
– The World of Warcraft gamer makes an appearance as a troll!


text:
A new initiative to improve transparency in the Bangladeshi garment manufacturing industry by mapping out every clothing factory in the country launches today.
The project, called “Digital RMG Factory Mapping in Bangladesh” (DRFM-B), will collect data on the factories and disclose it in a publicly available online map.
The map will show each factory’s location, number of employees, product types, certifications, trade union affiliations and export countries.
It comes after Bangladesh – which is still in the shadow of the Rana Plaza disaster – hit the headlines again earlier this year after authorities took a hard-line approach to workers and trade union officials who were protesting against low pay and poor working conditions in garment factories.
The DRFM-B project will be undertaken by Bangladesh-based BRAC University’s Centre for Entrepreneurship Development, in partnership with trade union Bangladesh Garment Manufacturers and Exporters Association (BGMEA). It will be funded by the C&A Foundation.
Field workers from BRAC University will visit every factory in Bangladesh over the next year to plot them on a map and collect the data. Verification will be crowdsourced from the public to ensure the information remains up to date and accurate.
The BGMEA will help the field workers gain access to the factories.
The project will kick off on 29 July in Dhaka with an event hosted by the partner organisations and the Bangladeshi Ministry of Labour. The map will go live in mid-2018, initially showing factories in Dhaka. The final version, showing all 20 Bangladeshi garment-producing districts, is expected to be completed by mid-2021.
“This project will send a strong signal to all stakeholders that transformative change is happening within the ready-made garment sector,” said Parveen Huda, project manager for DRFM-B.
Siddiqur Rahman, president of the BGMEA, added: “We believe [this initiative] will empower stakeholders across the industry, including workers, factory authority, brands, government, and civil society organisations to create positive changes and strengthen the effectiveness of improvements already under way.”

domain: news


text:
Laser treatment for nail fungus
Onychomycosis of the nails of the hands or feet is a disorder caused by fungi. In addition to the nail, the skin under the nail will also be affected. Most times, fungi that can cause onychomycosis thrive in moist environments such as pools or shoes that are tight and not aired out. Once one nail is affected, the fungus can spread to the healthy nails, affecting both feet. to ensure optimum healing.
Harmony XL PRO
Harmony XL PRO is a laser platform with 7 treatment handpieces that the physician changes based on the patient’s problem. Thus, it can be used for facial rejuvenation and skin tightening, it’s an efficient treatment for acne and acne scars, it eliminates vascular lesions (couperose, rosacea or those unsightly veins on your face or legs), it removes tattoos, eliminates axillary sweating (hyperhidrosis), evens out skin color. This medical equipment is only used by physicians and is approved by the FDA (Food and Drug Administration).
The treatment is usually oral, but it can be successfully accompanied by targeted laser treatment.
The results of the laser treatment for onychomycosis are slower, like all treatments for this problem.
DISCLAIMER: The results can vary from one person to the next, depending on age, sex, basal metabolic rate, family history, lifestyle and physical activity. All the treatments performed using the laser for onychomycosis (nail fungus) are carried out by a trained physician and customized based on the individual requirements in order to ensure the best possible results.

domain: medical


text:
ENJOY FREE POSTAGE & 20% OFF YOUR 1ST ORDER OVER £20
Seamstress necklace. Unique and quirky sewing themed jewellery, gift for a seamstress, dressmaker, designer. An unusual silver plated tape measure connector with silver plated sewing charms and stars on a silver plated chain
♡ Size and Materials• Silver plated cable chain in a choice of lengths• antiqued silver plated charms• a silver plated tape measure connector. (50mm x 16mm) * a little thimble • a vintage sewing machine • tiny buttons • with little stars in between.
♡ Personalisation optionsChoose up to two extra charms to create a unique necklace• 14mm silver plated alphabet initial• 12mm acrylic gem in birthstone colours• 12mm silver plated special birthday number• 10mm faceted glass rondelle birthstone• 10mm antiqued silver plated disc letter
♡ Necklace length guideWe recommend the following lengths:* Little Girls 5-8 years - 35cm* Older Girls 8-13 years - 40cm* Teens 14+ - 45cm*Adults - 45cm or 50cm
♡ Features• Ready gift wrapped in tissue and organza bag• Optional gift tag with personalised message• Letterbox sized packaging (when sent individually)• Can be sent direct
Adding product to your cart

domain: design


text:
Tiziano Terzani, born in Florence, Italy, was for 30 years Asia correspondent of the German magazine Der Spiegel. As such he was based in Vietnam, Hong Kong, China, Japan, and Thailand. From 1994 to 2004, the year he passed away, he was sharing his time between India and Italy. He has written several books, including The Forbidden Door; Good Night, Mister Lenin; Letters against the War, and A Fortune-Teller Told Me.
/ / Tiziano Terzani

domain: literature


A new test might facilitate diagnosis and drug development for Alzheimer’s disease
An international team of researchers have developed a new method for measurement of aggregated beta-amyloid – a protein complex believed to cause major nerve cell damage and dysfunction in Alzheimer’s disease. The new method might facilitate diagnosis and detection as well as development of drugs directed against aggregated beta-amyloid.
Alzheimer’s disease (AD) is the most common cause of memory decline and dementia. According to the Alzheimer World Report 2011, today around 36 million people suffer from Dementia (around 20 – 25 million are Alzheimer’s patients). These numbers will dramatically increase with the aging populations over the next few decades. For the year 2050 the expected number of dementia patients will be 115 – 200 million (70 – 150 million Alzheimer’s cases). It is therefore important to develop new therapies and diagnostic methods to detect and treat this complex chronic neurodegenerative brain disease.
Alzheimer’s disease is characterized by aggregates in the brain, containing a protein called beta-amyloid. The neuropathology of Alzheimer’s disease has recently been linked to the neurotoxic amyloid-β (Aβ) oligomers. The crucial role of Aβ oligomers in the early events of AD is experimentally underlined. Several recent results suggest that those oligomers may cause the death of neurons and neurological dysfunctions relevant to memory. Furthermore Aβ oligomers levels are increased in brain and cerebrospinal fluid samples from people with Alzheimer’s disease. This reflects the potential of Aβ oligomers as a marker for the early diagnosis of the disease.
An international team of scientists from Germany, Sweden and the U.S. have used a new method to quantify soluble variants of aggregated beta-amyloid (Aβ oligomers) in cerebrospinal fluid by flow cytometry. “We found that patients with a greater number of Aβ oligomers in the cerebrospinal fluid had a more pronounced disease,” says Dr. Alexander Navarrete Santos (the developer of this method and now employee of the Research Laboratory of the University of Halle, Department of Cardiothoracic Surgery), and first author of the study.
He analyzed the cerebrospinal fluid of 30 neurological patients, including 14 Alzheimer’s patients. “These samples provided from leading expert academic memory clinics in Germany and Sweden are of the best quality and are highly characterized in order to provide robust and reliable results on promising novel biomarker candidates”, Professor Harald Hampel of Frankfurt University, a lead investigator comments.
“Because of the limited number of samples, however, further study is needed to confirm the results,” said Dr. Oskar Hansson of Lund University. The study was an international cooperation with the University of California in the U.S., the Goteborg and Malmö Universities from Sweden and the University of Frankfurt in Germany.
The test might not only be used for the early detection of AD but can also be used when developing new and effective therapies for AD. A decline in the number of Aβ oligomers in cerebrospinal fluids could be a hint for the effectiveness of new drug therapies.
The results of the study will appear in the internationally renowned scientific magazine Journal of Alzheimer’s Disease in March 2012. Oskar Hansson (Lund University, Sweden) and Harald Hampel (University of Frankfurt, Germany) as senior authors of the study coordinated and supervised the work of the international research team including Drs. Alexander Navarrete Santos, Michael Ewers, Lennart Minthon, Andreas Simm, Rolf-Edgar Silver, Kaj Blennow, and David Prvulovic.


text:
Colorful wedding inspiration with funky rainbow backdrop and bold orange suit
"My vision for the shoot was to pack it full of color, queerness, and tender moments for this sweet couple - and Lexi + Sarah...
MOST VIEWED STORIES
- This Great Gatsby wedding in Walnut Grove, California, featured a casino speakeasy reception
- The queer Christmas story you’ve been waiting for
- Our lesbian love story: St. Pete Beach engagement with a proposal photographer
- Black and yellow poolside wedding in Palm Springs, California
- Home for the holidays anniversary photo shoot

domain: artistic


text:
Interserve has struck a rescue deal with its lenders but faces a battle to win the approval of shareholders after its biggest investor sought to clear out the struggling government contractor's board.
The company, which cleans schools, maintains prisons and builds roads, unveiled a £480m debt-for-equity swap on Wednesday under which its banks will write-off more than half its debt in return for millions of new shares.
Debbie White, chief executive, said the deal was “critical to the Interserve Group's future and all of its stakeholders”.
However, existing shareholders will be left with just 2.5pc of its shares.
New York hedge fund Coltrane Asset Management, which owns a 17pc stake, has called a meeting of shareholders and urged its fellow investors to back its bid to remove all of Interserve’s nine directors except for Ms White.
The Telegraph understands Coltrane does not believe the refinancing is necessary and thinks Ms White’s turnaround plan, aimed at cutting costs and boosting cash flow to pay down debt, is beginning to deliver.
It is proposing to replace the board with turnaround specialists David Frauman, who runs the European business of South African conglomerate Steinhoff, and Stuart Ross, the finance boss of private equity-backed human resources company NGA.
The rescue deal, which will need to be approved by a majority of shareholders, comes after months of crisis talks between Interserve, its lenders and the Government.
Existing shareholders will be offered the chance to buy the newly created shares from Interserve’s lenders, which include RBS, HSBC and BNP Paribas, at a discount to the market price.
The company had previously considered handing RMD Kwikform, its profitable construction materials business, over to lenders as part of the deal but that idea has since been shelved.
Instead Interserve will transfer the £350m of its remaining debt to the unit, leaving the rest of the business with net cash of £60m.
Shares rose 11pc to 14.6p in afternoon trade but are still down 95pc from their price two years ago.


text:
All You Want to Know about Handball. Handball History and facts, some of the facts about Handball Game and the History about Handball.
Shop high-quality unique Handball Quotes T-Shirts designed and sold by independent artists.
Handball Game observation, statistics, casting pictures With THSA-X handball game observation it is possible to record all game ...
THSA-X Handball Game Statistics Analysis APK. Analyze your handball game!
Famous quotes & sayings about A Football Game: Lou Holtz: One reason I won't compromise is because I believe honesty helps you win
Download THSA-X Handball Game Statistics Analysis apk 14.2.9 for Android.
Analyze your handball game! With THSA-X Statistics for Coaches - Players - GK
TOP 5 QUOTES: Drama and upsets, round 7 of the VELUX EHF Champions League had it all and this is how coaches and players reflected on their matches
The Austrian Way: Giving Young Athletes the Opportunity to Make it to the Top National and International Handball by Combining ...
Shop high-quality unique Playing Handball T-Shirts designed and sold by independent artists.

domain: hobby


text:
Furthermore, this study attempts to categorize certain “life events” by their triggering mechanism. Naturally, to each patient, the triggering mechanism will be different; however, by analyzing the association between adverse life events and relapses in a number of individuals with schizophrenia, the authors were able to specifically link certain causal factors with relapses. Lastly, the authors note that a noted increase in what they term “moderately severe” life events can also lead to a noted increase in psychotic symptoms for the patient.
This journal article studies ways in which to develop guidelines for nursing care professionals dealing with suicidal schizophrenics. Due to the high number of attempted suicides within this demographic, mental health professionals require expert direction on how to confront suicidal nature in patients and in what ways to best administer to their needs; all the while ensuring patient safety. The study found that immediately confronting the issue of suicide and the patient’s thoughts, feelings, views, and past history on the subject was the best way to assess suicide risk.
This study further supports how health care professionals dealt with the patient in question - C.S. Because no time was wasted in pursuing answers to questions relating to his thoughts and feelings towards suicide, medical professionals were able to fully gauge his intentions. In short, by tactfully attempting to understand the patient in the shortest time possible, medical professionals are able to more efficiently develop a care plan uniquely suited to the patient’s particular needs.
This journal article seeks to create a clear and concise body of knowledge for medical professionals on the provision of care for outpatients with bipolar disorders (Goossens et al, 2007). The study further


text:
Published at Monday, February 12th 2018, 20:25:31 PM by Bettine Vienne. bedroom
Want to use wood in an understated way? This full wooden wall adds warmth to grey, while housing a black glass door and industrial white light. Diamond patterns cover this feature wall, a focal point in a room full of wood. A lamp to the side illuminates its finer detail, as an old English ceiling sets the scene.
Looking for something more conventional? This low-lying bed blends perfectly with a smooth wooden wall surface. A wooden wall can be a great backing for art. These three forest scenes are offered warmth and simplicity by three-mid wooden panels.
Copyright © 2018 axpix.
All contents published under GNU General Public License. All rights of images and videos found in this site reserved by its respective owners. All trademarks mentioned belong to their owners, third party brands, product names, trade names, corporate names and company names mentioned may be trademarks of their respective owners or registered trademarks of other companies and are used for purposes of explanation and to the owner’s benefit, without implying a violation of copyright law.


The causes of mental ill-health are complex and varied, and how we look at mental health issues is too narrow.
Our culture generally holds, in uncomfortable tension, two common paradigms. One paradigm is that mental health is a mindset—if you just get a grip on your thoughts then your mental health issues will go away—the government’s love affair with Cognitive Behaviour Therapy (CBT) is one example of this in action. The second paradigm is that mental ill-health is a chemical imbalance—if you just get a grip on how your brain fires its receptors then your mental ill-health will go away—rising GP prescriptions for antidepressants show this in action.
Sitting alongside these paradigms, although often not explicit enough, is an ever-growing awareness of the links between trauma and mental ill-health. Whether that’s awareness of the impact of the cost-of-living crisis, covid lockdowns, discrimination, or abuse. However, the ‘solutions’ offered are often the same, especially for those who cannot afford longer-term therapy or access to other types of treatment.
The two paradigms, mentioned above, have their roots in ‘Cartesian dualism’, which has had a detrimental impact on western medicine by encouraging us to view the mind and body as separate entities, as opposed to intricately interlinked. Mental health charities have long campaigned for physical and mental health to be given equal priority; a concept known as ‘parity of esteem’.
Without getting into a debate on the merits of these two paradigms, it’s painfully obvious that one key driver is frequently excluded from the discussion and potential solutions to mental ill-health—the environment.
What are the environmental drivers of mental ill-health?
Air pollution is linked to schizophrenia and other psychotic disorders, and even small increases in air pollution are linked to rises in more common mental illnesses such as depression. Low-income households, often disproportionately composed of ethnic minority groups and disabled people, are more likely to experience low air quality indoors and outdoors. Days with high air pollution are linked to increased risks of needing community-based or hospital-based treatment, with children particularly vulnerable as their bodies and brains are still developing. Exposure to air pollution in childhood is linked to poor mental health by the age of 18 and exposure to air pollution in adolescence is a risk factor for depression.
Climate change is increasingly exposing the UK to more heatwaves and floods. There is a clear link between increased temperatures and mental health issues. Whilst the mental health impacts of flooding are not yet fully understood, the UK’s Public Health Register states that mental health issues ‘may prove to be the greatest health impact of flooding’. Eco-anxiety, related to the insufficient action being taken by society as a whole to tackle climate change, is on the rise. And whilst it is a very normal and valid response to the environmental challenges we face, eco-anxiety is having a hugely detrimental impact on the mental health of young people.
Access to nature has wide ranging benefits for physical and mental health. Research shows that levels of stress decrease as green spaces in a neighbourhood increase. Visits to green spaces, and views of greenery from the home, are also significant predictors of general health. Whilst green playgrounds can even improve well-being in schools. Studies show that access to nature can particularly benefit low-income communities and that the more biodiverse the green spaces, the better for our mental health. Nature even has the power to reduce our stress hormones and lower anxiety, via invisible chemicals (called phytoncides) emitted by some trees. This has given rise to ‘forest-bathing’ treatments.
Toxics such as pesticides are linked to depression and psychiatric disorders. Whilst endocrine disrupting chemicals (EDCs) are linked with an increase in depression. We are exposed to toxics in items such as cleaning products, make-up, toiletries, solvents, non-stick pans and some plastics. Worryingly, exposure starts in the womb. For example, exposure to flame retardants during pregnancy has been linked to increased anxiety symptoms in adolescents.
Gut health is now a major research area in mental health, which is fundamentally about the quality of our food production—a key environmental issue. For example, fruit and vegetables are less nutritious than they used to be and factory farming is reducing the omega-3 content of fish—omega 3 intake is widely linked to good mental health. Toxics such as pesticides in our food are linked to mental ill-health and even the quality of the soil in which our food is grown plays an important role. People with depression are less likely to have certain gut bacteria and further research is needed to understand whether lacking these bacteria causes depression, or if there’s another reason. However, the research field is increasingly leaning toward gut health as a key driver of mental health.
What does this mean for charities and funders?
It’s time charities and funders talked more about the environmental drivers of mental ill-health and what they mean for our work. At its best, our sector can innovate in a way that public bodies struggle to do. Our sector is already leading some great work, including on green social-prescribing, which, as a recent study carried out by The Wildlife Trusts demonstrates, not only works but is highly cost effective.
The Everyone’s Environment programme
NPC is working with over forty social and environmental charities and funders to better understand how different social groups in the UK will be affected by the climate and nature crises and related policy. Learning from the Everyone’s Environment programme research and discussion with people most affected will be shared widely with the sector.
Please get in touch if you would like to be involved and subscribe to our newsletter to keep up to date on publications and events. Funders and charities alike will also find further information in the NPC and the Environmental Funders Networks‘ Healthy People, Healthy Planet report and in NPC’s Environmental Philanthropy introductory guide.


text:
Allopolyploidy alters gene expression in the highly stable hexaploid wheat
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Hexaploid wheat (Triticum aestivum) contains triplicated genomes derived from three distinct species. To better understand how different genomes are coordinated in the same nucleus of the hexaploid wheat, we globally compared gene expression of a synthetic hexaploid wheat with its diploid (Aegilops tauschii) and tetraploid (T. turgidum) parents by cDNA-AFLP display. The results suggested that the expression of a significant fraction of genes was altered in the synthetic hexaploid; most appeared to be diminished and some were activated. We characterized nine cDNA clones in details. Cytogenetic as well as genomic sequence analyses indicated that the gene silencing was not due to chromosome/DNA loss but was caused by gene regulation. Northern and RT-PCR divided these genes into three groups: (I) four genes were down-regulated nonspecifically, likely involving both parental orthologues; (II) four genes were down-regulated in an orthologue-dependent manner; (III) one gene was activated specifically in the synthetic hexaploid wheat. These genes were often altered non-randomly in different synthetic hexaploids as well as natural hexaploid wheat, suggesting that many of the gene expression changes were intrinsically associated with polyploidy.
Averett, J.E. 1980. Polyploidy in plant taxa: summary. In: W.H. Lewis (Ed.) Polyploidy: Biological Relevance, Plenum Press, New York.
Bachem, C.W.B., van der Hoeven, R.S., de Bruijn, S.M., Vreugdenhil, D., Zabeau, M. and Visser, R.G.F. 1996. Visualization of differential gene expression using a novel method of RNA fingerprinting based on AFLP: analysis of gene expression during potato tuber development. Plant J. 9: 745–753.
Blanc, G., Barakat, A., Guyot, R., Cooke, R. and Delseny, D. 2000. Extensive duplication and reshuffling in the Arabidopsis genome. Plant Cell 12: 1093–1101.
Comai, L., Tyagi, A.P., Winter, K., Holmes-Davis, R., Reynolds, S.H., Stevens, Y. and Byers, B. 2000. Phenotypic instability and rapid gene silencing in newly formed Arabidopsis allotetraploids. Plant Cell 12: 1551–1568.
Durrant, W.E., Rowland, O., Piedras, P., Hammond-Kosack, K.E. and Jones, J.D.G. 2000. cDNA-AFLP reveals a striking overlap in race-specific resistance and wound response gene expression profiles. Plant Cell 12: 963–977.
Dvorak, J. 1998. Genome analysis in the Triticum-Aegilops alliance. In: A.E. Slinkard (Ed.) Proceedings of the 9th International Wheat Genetics Symposium (Saskatoon, Saskatchewan, Canada) 1: 8–11. University Extension Press, University of Saskatchewan.
Feldman, M., Galili, G. and Levy, A.A. 1986. Genetic and evolutionary aspects of allopolyploidy in wheat. In: C. Barigozzi (Ed.) The Origin and Domestication of Cultivated Plants, Elsevier Science, New York, pp. 83–100.
Friebe, B. and Gill, B.S. 1994. C-band polymorphism and structural rearrangements detected in common wheat (Triticum aestivum). Euphytica 78: 1–5.
Friebe, B., Mukai, Y. and Gill, B.S. 1992. C-banding polymorphisms in several accessions of Triticum tauschii (Aegilops squarrosa). Genome 35: 192–199.
Galili, G. and Feldman, M. 1983. Diploidization of endosperm protein genes in polyploid wheats. In: Proceedings of the 6h International Wheat Genetics Symposium (Saskatoon, Saskatchewan, Canada), pp. 1119–1123. University Extension Press, University of Saskatchewan.
Galili, G. and Feldman, M. 1984. Intergenomic suppression of endosperm protein genes in common wheat. Can. J. Genet. Cytol. 26: 651–656.
Galitski, T., Saldanha, A.J., Styles, C.A., Lander, E.S. and Fink, G.R. 1999. Ploidy regulation of gene expression. Science 285: 251–254.
Gill, B.S. 1991. Nucleo-cytoplasmic interaction (NCI) hypothesis of genome evolution and speciation in polyploid plants. In: T. Sasakuma and T. Kinoshita (Eds.) Nuclear and Organellar Genomes of Wheat Species, Kihara Memorial Foundation, Yokohama, Japan, pp. 48–53.
Gill, B.S. and Friebe, B. 2002. Cytogenetics, phylogeny and evolution of cultivated wheats. In: B. Curtis (Ed.) Wheat Improvement, FAO, in press.
Guo, M., Davis, D. and Birchler, J.A. 1996. Dosage effects on gene expression in a maize ploidy series. Genetics 142: 1349–1355.
Hart, G.E. 1979. Evidence for a triplicate set of glucosephosphate isomerase structural genes in hexaploid wheat. Biochem. Genet. 17: 585–598.
Hart, G.E. 1996. Genome analysis in the Triticeae using isozymes. In: P.J. Jauhar (Ed.) Methods of Genome Analysis in Plants, CRC Press, Boca Raton, FL, pp. 195–209.
Huang, S., Sirikhachornkit, A., Su, X., Faris, J., Gill, B.S., Haselkorn, B. and Gornicki, P. 2002. Genes encoding plastid acetyl-CoA carboxylase and 3-phosphoglycerate kinase of the Triticum/Aegilops complex and the evolutionary history of wheat. Proc. Natl. Acad. Sci. USA 99: 8133–8138.
Heun, M., Schafer-Pregl, R., Klawan, D., Castagna, R., Accerbi, M., Borghi, B. and Salamini, F. 1997. Site of einkorn wheat domestication identified by DNA fingerprinting. Science 278: 1312–1314.
Imaizumi, T. Kanegae, T. and Wada, M. 2000. Cryptochrome nucleocytoplasmic distribution and gene expression are regulated by light quality in the fern Adiantum capillus-veneris. Plant Cell 12: 81–95.
Kashkush, K., Feldman, M. and Levy, A.A. 2002. Gene loss, silencing and activation in newly synthesized wheat allotetraploid. Genetics 160: 1651–1659.
Ku, H.-M., Vision, T., Liu, J. and Tanksley, S.D. 2000. Comparing sequenced segments of the tomato and Arabidopsis genomes: large scale duplication followed by selective gene loss creates a network of synteny. Proc. Natl. Acad. Sci. USA 97: 9121–9126.
Lee, H.-S. and Chen, Z.J. 2001. Protein-coding genes are epigenetically regulated in Arabidopsis polyploids. Proc. Natl. Acad. Sci. USA 98: 6753–6758.
Liu, B. Brubaker, C.L., Mergeai, G., Cronn, R.C. and Wendel, J.F. 2001. Polyploid formation in cotton is not accompanied by rapid genomic changes. Genome 44: 321–330.
Liu, B., Vega, J.M., and Feldman, M. 1998. Rapid genome changes in newly synthesized amphiploids of Triticum and Aegilops. II. Changes in low-copy coding DNA sequences. Genome 41: 535–542.
MacFadden, E.S. and Sears, E.R. 1944. The artificial synthesis of Triticum spelta. Rec. Soc. Genet. Am. 13: 26–27.
MacFadden, E.S. and Sears, E.R. 1946. The Origin of Triticum spelta and its free-threshing hexaploid relatives. J. Hered. 37: 81–69, 107–116.
Madlung, A., Masuelli, R.W., Watson, B., Reynolds, S.H., Davison, J. and Comai, L. 2002. Remodeling of DNA methylation and phenotypic and transcriptional changes in synthetic Arabidopsis allotetraploids. Plant Physiol. 129: 733–746.
McClintock, B. 1984. The significance of responses of the genome to challenge. Science 226: 792–801.
McIntosh, R.A., Hart, G.E., Devos, K.M., Gale, M.D. and Rogers, W.J. 1998. Catalogue of gene symbols for wheat. Proceedings of the 9th International Wheat Genetics Symposium (Saskatoon, Saskatchewan, Canada), 5. University Extension Press, University of Saskatchewan.
Mittelsten-Scheid, O., Jakovleva, L., Afsar, K., Maluszynska, J., Paszkowski, J. 1996. A change in ploidy can modify epigenetic silencing. Proc. Natl. Acad. Sci. USA 93: 7114–7119.
Mukai, Y., Endo, T.R. and Gill, B.S. 1991. Physical mapping of the 18S-26S rRNA multigene family in common wheat: identification of a new locus. Chromosoma 100: 71–78.
Nelson, J.C., Deynze A.E.V., Autrique, E., Sorrells, Lu, Y.H., Merlino, M., Atkinson, M. and Leroy, P. 1995. Molecular mapping of wheat homoeologous group 2. Genome 38: 516–524.
Ozkan, H., Levy, A.A. and Feldman, M. 2001. Allopolyploidyinduced rapid genome evolution in the wheat (Aegilops-Triticum) group. Plant Cell 13: 1735–1747.
Sakamoto, S. 1973. Patterns of phylogenetic differentiation in the tribe Triticeae. Seiken Ziho 24: 11–31.
Sambrook, J., Fritsch, E.F., and Maniatis, T. 1989. Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory Press, Plainview, NY.
Shaked, H., Kashkush, K., Ozkan, H., Feldman, M. and Levy, A.A. 2001. Sequence elimination and cytosine methylation are rapid and reproducible responses of the genome to wide hybridization and allopolyploidy in wheat. Plant Cell 13: 1749–1759.
Song, K., Lu, P., Tang, K. and Osborn, T.C. 1995. Rapid genome change in synthetic polyploids of Brassica and its implications for polyploid evolution. Proc. Natl. Acad. Sci. USA 92: 7719–7723.
Wendel, J.F. 2000. Genome evolution in polyploids. Plant Mol. Biol. 42: 225–249.
Wolfe, K.H. and Shields, D.C. 1997. Molecular evidence for an ancient duplication of the entire yeast genome. Nature 387: 708–713.
- Allopolyploidy alters gene expression in the highly stable hexaploid wheat
Plant Molecular Biology
Volume 52, Issue 2 , pp 401-414
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- gene silencing
- Industry Sectors


These 6 Android phones made our list of the best smartphones in the world — and they all still have a headphone jack
Smartphones with headphone jacks are a rare find in 2019, but you'll still be able to plug in your headphones with these top-notch Android phones.
Razer made a $100 controller that lets you use your phone like a Nintendo Switch, but the best feature only works with certain devices
Razer's new controller is designed like a pair of Nintendo Joy-Cons, and it can turn a phone into a portable video game console.
Smartphones are really expensive right now, and you may not actually need to get a new device.
Which smartphone should you buy? Here are the best phones of 2018, from the OnePlus 6T and Google Pixel 3, to the iPhone XS and Samsung Galaxy S9.
It’s time for tech giants to retire the ‘keynote’ — Apple, Google, and others are all making the same mistake with their product launches
Opinion: Steve Jobs' keynote presentations for Apple have inspired countless copies, where a rotating carousel of company executives stand on a stage to debut new gadgets and services. But the act is getting old.
The new iPhone XS Max and Galaxy Note 9 are among the biggest, best, and most expensive phones you can buy — here's how they compare
The iPhone XS Max and the Galaxy Note 9 are among the two best phones you can buy. Both feature a big, beautiful display, a top-of-the-line camera, and a premium look and feel. But there are a few key differences between the phones.
It goes against the common sense that smaller, lighter devices are the way to go while traveling.
I've been using Samsung's new $1,000 Galaxy Note 9, and it's the only smartphone actually worthy of its high price tag
I actually tried using the S Pen a lot more with the Galaxy Note 9, and I've come to love it.
The Galaxy S9, the Galaxy S9 Plus, and the new Galaxy Note 9 — Samsung's premium flagship phones for 2018 — are all heavy hitters. You can't go wrong with any of them, but if you're on the fence, there are some subtle differences that make the newest phone, the Galaxy Note 9, stand out.
The Samsung Galaxy Note 9 has almost every feature you could want in an Android phone. The $1,000 price tag is much more justified for the Note 9 than the iPhone X.
With the Galaxy Note 9, Samsung didn't change a whole lot: the design is similar to last year, the operating system isn't brand-new, and even the colors are similar to what Samsung has offered in the past. The phone does, however, have four innovative new features worth considering.
All the major similarities and differences between Samsung's high-end smartphones, the Galaxy S9 and the Galaxy Note 9
There are a lot of similarities between Samsung's latest high-end smartphones, the Galaxy S9, Galaxy S9+, and Galaxy Note 9. But there are a few key differences worth keeping in mind if you're trying to decide which one to buy.
The Pixel 2 is the best smartphone camera. But it's dominance is challenged by the Galaxy Note 9 thanks to its variable aperture and 2x optical zoom lens.
The Galaxy Note 9 is Samsung's latest high-end smartphone. I've spent the last 24 hours playing around with the new phone, and a handful of features caught my eye, like an improved S Pen, subtle design changes, and the stunning display.
Samsung announced the Galaxy Note 9 on Thursday with the same price tag as the iPhone X. But that four-figured price tag might be slightly more justifiable on the Galaxy Note 9.
Samsung made a slew of announcements this week at Unpacked 2018, its biggest conference of the year, which took place in Brooklyn. As expected, Samsung unveiled the Galaxy Note 9, the large-phone successor to last year's Galaxy Note 8. But the Korean company also had a few surprises up its sleeve.
The new Samsung Galaxy Note 9 is finally here, and it comes with a few new features but a similar overall design. Here's how it's similar to and different from last year's model, the Galaxy Note 8.
Samsung just unveiled its first-ever Bixby smart speaker alongside its new Galaxy Note 9. They also showed off improved S Pen features, a new Galaxy watch, and a partnership with Fortnite and Spotify.
Apple's iPhone X isn't the only $1,000 smartphone anymore.
Samsung just accidentally posted a video to YouTube that reveals more details about the Galaxy Note 9
Samsung just accidentally leaked details about the Galaxy Note 9, less than a week before it's set to unveil the new phone. Samsung New Zealand uploaded an intro video of the phone to its YouTube page, revealing details about both the phone's design and storage options.


text:
THOUSANDS of Irish homeowners are set for a big blow as a leading Irish bank has announced interest rate hikes.
Bank of Ireland will increase rates for a number of mortgage and deposit products.
The rise followings a cumulative increase of 2.5 per cent in European Central Bank rates since July 2022.
For mortgages, customers will see a 0.75 per cent increase in fixed rates on new mortgages.
There will also be a 0.50 per cent increase for fixed rates available to existing mortgage customers including those coming to the end of their fixed rate period and seeking to re-fix their mortgage.
It will also affect tracker rate or variable rate customers who wish to move to a fixed rate.
Variable rates and tracker rates will remain unchanged.
However, with those who already have credit approval and who draw down the mortgage by February 21, 2023 still able to avail of the previous fixed rates.
In practical terms, while standard rates for one year for Private Dwelling Homes were originally 3.15 per cent, under the new rates that will now rise to 3.90 per cent for new businesses.
For existing customers, while the rate used to be at 2.90 per cent for 1 year for Private Dwelling Homes, this will now rise to 3.40 per cent.
Most read in Money
In regard to deposit accounts, there will be a 0.50 per cent increase for Regular Saver personal deposit accounts.
This will allow customers to earn 0.75 per cent on Mortgage Saver and Child Save accounts – capped at €15,000 and €10,000 respectively.
The cap was originally at 0.25 per cent.
Bank of Ireland will also launch a new one year term deposit account for personal customers at 0.50%, capped at €100,000.
The fixed rates on new mortgages will be effective from today, while deposit rate changes will change from this Friday, January 27.
Meanwhile, the banking app Revolut is primed to offer main account facilities to its two million Irish customers.
And experts predict this will shake up the sector.
Now it has been granted the use of Irish IBANs, the online operator is just months away from offering its customers a one-stop banking shop with direct debits, and bill and salary payments.
“The first issue was addressed early last year when Revolut officially became a bank in Ireland. Deposits of up to €100,000 are now protected by the Lithuanian bank guarantee scheme.
“And now the second issue has been addressed."


This file contains additional information, probably added from the digital camera or scanner used to create or digitize it.
If the file has been modified from its original state, some details may not fully reflect the modified file.
Nathalie Kosciusko Morizet, Secretary of State to the Environment, France
July 24, 2008
France, climate, change, environmental, degradation, transportation, ecological, footprint, greening, lifestyles
"Last autumn France launched a new environmental campaign which imposed many inventive, if not radical, ideas on combating climate change. It envelops a change on several aspects of everyday life from public transportation, personal automobiles and housing."


text:
CLOSE to 250,000 local and foreign visitors are expected to arrive in Cebu in the next two weeks to join the Sinulog festival.
With this, the Department of Tourism (DOT) Central Visayas assured that the province remains safe despite the United Kingdom's issuance of a travel advisory discouraging its nationals from traveling to southern Cebu.
In a forum last Tuesday, January 8, GMR Megawide Cebu Airport Corporation Terminal 1 operations head Neneth Castillon said that last year, they recorded around 223,000 tourist arrivals for Sinulog.
"For 2019, we are projecting a four percent increase in domestic and international arrivals. We expect more because of the participation of a contingent from Wonju, South Korea in the grand parade (on Sunday, January 20)," she said.
With the Mactan Cebu International Airport having seven flights connecting flights to South Korea daily, Castillano said it is not a surprise that South Koreans remain as the top tourists in the province.
"So this is why were expecting an influx of travelers. Were ready and were preparing a warm welcome for both our local and foreign visitors," she said.
The airport management is also working closely with the DOT, especially on the Balik Cebu program on Thursday, January 17.
The Balik Cebu program aims to offer tourists and returnees an “unparalleled Cebu experience."
Judy Gabato, DOT-Central Visayas chief tourism operations officer, said they are closely coordinating with the police to keep the festival safe and peaceful, especially for tourists.
"Were actively coordinating, based on our Central Visayas situation. Our local and and national law enforcement agencies are fully capable on the updates of our travelers' safety concerns. Were very happy with the presentation of our authorities last Monday (January 7) that it's very clear, there are no recent issues when it comes to terrorism in Central Visayas, specifically in southern Cebu. There are also no cancelations, in fact, there are a lot of inquiries for southern Cebu. This is really positive for us. Were still monitoring, it doesn't mean were complacent," she said.
Meanwhile, Sinulog Foundation Inc. (SFI) marketing and promotions head Stephanie Villarico said they will start selling tickets for the grand parade on Thursday, January 10.
Tickets ranging from P1,000 to P3,000 are available at the SFI office at the Cebu City Sports Center, the concierge desk at Robinsons Galleria and at the Balik Cebu booth in Ayala Center Cebu.
Online purchase is also available for spectators who cannot physically come to the ticketing booths.
Green and pink tickets will still cost P1,000; yellow tickets, P1,200; blue tickets, P2,500; and red tickets at P3,000.
Villarico said they have prepared around 7,000 tickets for the event.
"Were pretty okay in terms of preparations. We have not actively invited anyone, except for the President (Rodrigo Duterte). Any politician is welcome to join the festival, but they will not be given speaking parts. Should he grace our invitation, only the President will be given a chance to speak," she added.

domain: travel


text:
Nagpur: What happens when a Corporator of ruling party participates in a Bullfight which is illegal and banned by the Supreme Court of India?
In an act of willful disregard for law, Chairman of Maharashtra Construction Workers Welfare Board and BJP Corporator Munna Yadav is said to have participated in a Bullfight organized in Kalkuhi village in MIHAN area. The event was said to have been organized in a ground near the lake. The husband of Lady Sarpanch Vittal Mohod and Munna Yadav are said to have been organizing this event for the past three to four years. The Bull owned by Munna Yadav is also made to participate in the event. Munna Yadav’s Bull is said to have been a champion for the last two years. The bullfight event is said to have started at 12 pm on December 14, 2016.
Sources told Nagpur Today that during the Bullfight which is organized in Kalkuhi village in MIHAN area, one of the bulls which are losing is often bloodied with injuries sustained from goring by the rival bull.
On December 14, 2016, Munna Yadav had reached the venue with his priced bull to participate in the event. He can be prominently spotted in the video recorded by one of the onlookers. A social worker identified as Suraj Lolge had called up 100 number and reported the matter. He then went on to call the cops of the Sonegaon Police Station under whose jurisdiction the event is organized. However, the cops refused to even acknowledge or register a case against Munna Yadav for reasons best known to them.
At the time of filing the story, Deputy Commissioner of Police (Zone-1) Deepali Masirkar had already reached Sonegaon Police Station and was investigating into the facts. However, no case has been filed against the erring Corporator so far.
In May 7, 2014, Supreme Court of India had passed a landmark judgment in favour of PETA India and the Government body the Animal Welfare Board of India (AWBI) clarifying that bulls must not be used in Jallikattu, bull races, bullfights or any other type of performance. The investigations revealed that terrified bulls are given liquor, deliberately disoriented, have their tails twisted and bitten and are stabbed, punched, jumped on and dragged to the ground. During races, bulls are often hit with nail-studded sticks to provoke them. In bullfights, the round ends when one of the bulls is either killed or manages to flee.

domain: law


text:
Pet Talker, Kate Solisti, has done a lot of research when it comes to quality foods for your kitty.
Kate stresses that it is important to note that these foods are recommended from her friends and colleagues that have done a lot of research in this area – and if they are bought out by a larger cat food company, then the quality and effectiveness of the ingredients could most certainly change.
Solisti recommends that you buy cat food from a locally owned store – rather than from Petco or Petsmart – and definitely not the grocery store. Solisti says that if you go to the grocery store for your kitty’s food then the food is already highly processed. I would imagine that Whole Foods or another natural food store might be an exception in this situation.
Below are a list of recommendations from Solisti:
Grain-free Dry Food for Cats**:
Pure Vita www.nutrisourcedogfood.com
Mulligan Stew www.mulliganstewpetfood.com
Orijen & Acana www.orijen.com
Great Life www.doctorsfinest.com
Taste of the Wild www.tasteofthewildpetfood.com
Canned for Cats:
Treats for Dogs & Cats:
More Like This
Boulder Dog Food Company www.boulderdogfoodcompany.com
Great Life freeze-dried liver treats & "Irresistibles" toppings
Stella & Chewy’s "Carnivore Crunch" and "Carnivore Kisses"
Shop owners who keep up on the pet foods they sell:
Lori Leigh Moreland
Pet Empawrium & Spaw
Quality Paws Natural Pet
Paws & Claws
Although Kate recommends that no cat should ever be eating dry food alone – she says that she included the list of dry foods, so that the kitty could transition to a grain free food. It is best to only feed kitties wet food.
What is your favorite cat food for your kitty? What are your favorite treats for cats? Please send us a photo of your kitty with his favorite food or gourmet cat treats!

domain: pet


text:
The Directorate General of Civil Aviation (DGCA) has provided Akasa Air with its Air Operator Certificate (AOC), and accordingly, the airline plans to begin commercial operations later this month.
The airline said the grant of the AOC was the final step of a comprehensive DGCA process and marked the satisfactory completion of all regulatory and compliance requirements. This included successfully completing several proving flights under the supervision of the country's aviation regulator. Akasa Air is the first Indian airline to complete its AOC process using the eGCA digital platform.
Vinay Dube, Founder and Chief Executive Officer, Akasa Air, said, 'We now look forward to opening our flights for sale, leading to the start of commercial operations by late July.'
The airline's code is QP, and it received its first 737 MAX in India on June 21. It will commence commercial operations with two new Boeing 737 MAX jetliners, subsequently adding new aircraft every month. By the end of the FY23 it plans to induct 18 aircraft and thereafter 12-14 aircraft every 12 months. Its entire order of 72 aircraft will be delivered by 2027.


text:
Charley Bates was an outsider. Always the third wheel to the Artful Dodger and Oliver Twist’s double-act in Fagin’s gang. Then he became the redeemed thief who managed to turn himself into ‘the merriest young grazier in the whole of Northamptonshire.’ But would he remain on the straight and narrow or go back to his criminal ways? What he needed was a mission to keep himself honest. And then he got one: a chance to bring justice to bear on a villain from his past, Monks, the half-brother of Oliver Twist. Getting even would mean a trip from the Thames to the Mississippi and help from old friends to right the wrongs done by the ‘creature’ as Charley thought of him.
Field Lane reflects a 19th century world filled with social injustice, slavery, drug abuse and Royal privilege. Its fictional characters become intertwined with real-life historical figures such as the Duchess of Kent (the mother of Queen Victoria), the scientist Michael Faraday and Sam Clemens, the boy who would become Mark Twain. At the climax justice is indeed served in line with Charles Dickens’ wish. But by whom?
Published 28th February 2024
BRAND NEW , COPIES SIGNED BY THE AUTHOR
John Sodeau is currently Emeritus Professor of Chemistry at University College Cork, Ireland. Previously he taught and researched at Universities in UK, USA and Japan. Over a period of 40 years, he has written many hundreds of thousands of words, but this novel is his first work combining his interests in literature, history, social justice and science. He is sometimes described as an air pollution and climate change campaigner.
John was kind enoug to write a short piece for our blog on the genesis of the book -
2 Reviews Hide Reviews Show Reviews
Mr. Sodeau’s evocative account of the adventures of Charley Bates transported me to the underbelly of 19th century London where familiar literary and historical figures commingle with his artfully created cast. Like it or not, the reader is dragged into the murky streets of London where all manner of corruption exists. The role of the apothecary and the origins of Tanquery Gin are just two topics that are effectively woven into this tale. You will be disgusted by child prostitution, and appalled by the ingredients in Royal Caribbean Cream. The novel is not without humor as Charley and the gang run scams, including their crude take on Shakespearian performances. Although distant from our current society, parallel themes of addiction and social injustice are explored both in London and New Orleans. The rescue of Oliver Twist, and Charley’s pursuit of Monks brought light into otherwise bleak surroundings. This is a realistic depiction of a world where Oliver Twist emerged, and it both entertains and enlightens. Looking forward to the next installment!
Cleverly developing a plot based on a lesser known Dickens character while also expanding on what we already know about the major cast of Oliver Twist, this book takes one a little closer to the darker side of 19th century London and beyond, to New Orleans and its environs. In doing so the reader is able to immediately draw parallels not only with the world created and described in what might be termed more wholesome ways by Dickens but also that which features in the novels of Mark Twain. The story essentially revolves around sex drugs and money but also draws heavily on aspects of slavery which were prevalent at the time. This said, these issues are not described in a salacious manner- but their role in the plot development are paramount. The reader is cleverly introduced to new concepts in the form of potentially addictive beverages based on morphine and caffeine, all interspersed with highly plausible science. In this regard the Chemistry Professor background of the author is clearly visible as he describes purification by crystallization and other separation and extraction methods while often citing established scientists of that era. Some of the ‘science’ involved is referred to in explanatory ‘interval’ chapters where the author seems to don his natural ‘lecturer’ persona in order to inform and educate the reader! Coming in the middle of a series of first-person chapters each introducing a particular character or set of characters these intervals are quite entertaining. This is a not a ‘who done it’ novel- it is clear from quite early on who the villain actually is. However, the main character and his companions have to go to great lengths in order to even get close to the villain often encountering other difficult and equally villainous characters before the final conclusion is reached. For a first novel the plot development with its historical references and attention to scientific detail is very good indeed such that one is easily able to be drawn in to the world that the author has created- albeit with the help of the other more-famous authors! I am greatly looking forward to reading the next ‘chapter’ in the story, in due course.


On October 13, the Supreme Court of Hawai`i announced it will review a lower court decision that an outdated, 25-year-old Environmental Impact Statement (EIS) provides enough information to approve a major new development project on O`ahu’s famous North Shore. The case pits local community members, environmentalists and surfers against the proposed expansion of the Turtle Bay Resort. Kuilima Resort Company, owner of the property, is seeking approval for five new hotels and 1000 luxury condos, which would permanently alter the North Shore’s rural landscape.
The Supreme Court will review a split 2-1 decision by the state Intermediate Court of Appeals that denied a request for an updated review of the proposed development’s environmental and community impacts. The request came from community group Keep the North Shore Country and Sierra Club, Hawai`i Chapter.
The appeals court majority held that no further review would ever be required unless the "project itself" changed. This ruling could be taken to absurd conclusions. For example, Turtle Bay’s 1985 EIS could remain valid forever, even if there are major hurricanes, drastic shoreline erosion or significant changes to the surrounding community.
As community and environmental groups have pointed out, the North Shore has already undergone significant changes since the EIS was issued.
"Much has changed in the last two decades, most notably the rapid growth in traffic congestion along the narrow, two-lane Kamehameha Highway, the only regional roadway on the North Shore," said Gil Riviere, President of Keep the North Shore Country. "The expansion plan is extremely unpopular due to concerns of over-development of the rural area, traffic gridlock, new environmental concerns such as endangered monk seals pupping on the resort property, and the likelihood of disturbing ancient Hawaiian burials."
Six community organizations represented by Earthjustice — Conservation Council of Hawai’i, Surfrider Foundation, Hawai’i’s Thousand Friends, Life of the Land, Maui Tomorrow Foundation, and KAHEA: The Hawai’i Environmental Alliance — filed a "friend of the court" brief in support of the plaintiffs’ position. Their involvement was necessitated by the broad negative ramifications of the lower court’s ruling, which could impact development projects throughout the islands.
"The purpose of an EIS is to ensure decision makers have the necessary information about the human and environmental impacts of a proposed project," said Robert D. Harris, Director of the Sierra Club, Hawai`i Chapter. "This lets the community be involved in the process and ensures smart decisions are made," he continued. "Plainly, we cannot rely upon obsolete information to approve a project that is clearly no longer appropriate for the community."
"This is really about applying a little common sense to development plans," said Earthjustice attorney Isaac Moriwake. "Preventing further review, just because the project itself hasn’t changed, makes no sense. It is precisely because the project hasn’t changed, despite an entire generation of change on the North Shore, that we need an update on the true impacts of the original proposal."


The UK's pension watchdog today delivered on its promise to bare its teeth by issuing its first ever fine to a public sector pension scheme.
The Pensions Regulator (TPR) slapped the London Borough of Barnet with a £1,000 penalty for failing to submit its 2016 scheme return.
TPR has been vocal in recent months over plans to get tough on pension scheme failings. It has promised to "intervene" where companies are treating schemes unfairly.
Meanwhile, the government is consulting on plans to give TPR proactive, rather than reactive, powers to step in to prevent BHS-style corporate failings following large pension shortfalls.
TPR issued Barnet council with a notice to file its return on 9 July 2016, setting a deadline of 12 August. The North London borough failed to file the return and respond to the correspondence. This led to the matter being referred to TPR’s Determinations Panel on 24 February 2017.
“It is the legal responsibility of trustees and managers to submit a scheme return by the deadline," said TPR executive director of frontline regulation Nicola Parish.
"This is one of the most basic regulatory requirements for trustees and managers and it is vitally important that we have up-to-date information about schemes so we can carry out our role effectively. We are also concerned if it is not submitted, as this may signal further problems within the administration of the scheme. Good scheme governance is a key factor in achieving positive outcomes for members. The action we took in this case demonstrates our commitment to this.
We have shown that where managers and trustees are failing with their basic duties, including in large public service schemes such as this one, we will use our powers to intervene.
A penalty notice was issued to London Borough of Barnet, as scheme manager, on 13 April and paid on 9 June.
A Barnet Council spokesperson said: “The council recognises that this is totally unacceptable. Due to a specific resourcing issue, the 2016 annual scheme return was not filed in time by our supplier. The fine has been paid by them and steps taken to ensure this will not reoccur.”


text:
As tensions might drag over the next decade, investors have to learn to operate under prolonged uncertainty, said Warburg Pincus' Charles Kaye.World Economyread more
Billionaire investor Howard Marks, the co-chairman of Oaktree Capital, predicts there won't be a recession in the U.S. for another two years.US Economyread more
Network officials also said voters should expect more of a Koch focus on grassroots activism throughout the 2020 election cycle.Politicsread more
One person was killed and five others wounded on Thursday in a shooting on the streets of Washington, D.C., not far from the White House, police said.U.S. Newsread more
Stores are extending hours and cities are spending on light shows as China tries to encourage consumers to spend more money at night.China Economyread more
New research suggests fewer girls pursue careers in STEM — science, technology, engineering and math — because they're better than boys at reading.Closing The Gapread more
Stocks in Asia Pacific edged up in Friday afternoon trade as a series of developments overnight on the U.S.-China trade front dampened hopes of a deal being reached between...Asia Marketsread more
GM's usage of temporary workers, potential closure of plants and health care contributions remain major sticking points, according to people familiar with the talks.Autosread more
In a room full of avowed capitalists, policies that sound to some like socialism are bound not to go over well.Delivering Alpharead more
Trump has criticized Facebook numerous times since becoming president, most recently posting on Twitter that the company's proposed digital currency, libra, will "have little...Technologyread more
Republicans and Democrats have long since separated themselves by ideology, leaving each more uniformly conservative or liberal than ever. And now a new data analysis by the...Politicsread more
If you're like me, chances are you're constantly getting bombarded by robocalls. You know the type: You pick up the phone only to hear some pre-recorded message — sometimes not even in English — about how you owe someone money or you've won a free vacation to Barbados.
These sorts of robocalls are smarter than ever, too. Spammers are capable of spoofing the area code where you live so that it appears to be a local call or even one from a legitimate business you've used. And of course you answer: Maybe it's a neighbor, the drug store or a doctor calling.
Usually it isn't.
I'm going to walk you through how some of those calls happen in the first place, and how to start blocking them.
Anyone can pay to make millions of robocalls. There are legitimate businesses that follow the law which you can pay to have your message sent out to people around the globe. Advanced tools let you pick the area code the call originates from, so someone can target a specific area and use a local number.
Other people and groups around the globe don't necessarily care about US laws, so they're able to call you from pretty much anywhere — but with similar tools to what legitimate businesses offer. They usually call for private info such as social security numbers and bank accounts, or cash, with the hopes they'll trick you into giving it away.
If you see a number you don't recognize, even if it's from a local area code, let the message go to voicemail. If it's important — say a message from a school nurse — you'll get a voicemail.
If you pick up, you should end the call immediately after you realize it's a pre-recorded message.
"Hang up the phone," FTC attorney Kati Daffan advises. "Don't press one to speak to a live operator. And don't press any other number to get off the list. If you respond by pressing any number, it will probably just lead to more robocalls."
Your first line of defense is to sign up for the FTC's Do Not Call Registry. It's illegal for telemarketers to call you if you're on it, though plenty still do.
Sign up for the FTC's Scam Alerts. This will help you know about current robocalls and scams that have been reported to the FTC, such as the two I mentioned above.
You should also download apps that have frequently-updated lists of known robocall numbers that are automatically blocked. The US wireless industry group CTIA recommends several apps for Android and iPhone, including the app Mr. Number, which is highly rated in both app stores.
I downloaded Mr. Number and it offers a lot of options, including the ability to automatically block known scams, block suspected fraudsters, block numbers that are hidden on purpose, block numbers that aren't in your contacts and more.
It's almost impossible to completely avoid robocalls -- unless you block everyone who's not in your address book with an app -- since it's easy for scammers to create a new number and call you again. Still, you should know how to block a number on your phone. Here's how to do that on Android (the steps might vary by device) and on the iPhone:
If you follow the steps above you should receive fewer robocalls. If you still get them, you should file a complaint with the Federal Trade Commission. Doing so can help the FTC detect patterns and potentially stop whoever's sending those calls in the first place.


Information reaching us indicates that about 12 directors and top staff of the Economic and Financial Crimes Commission (EFCC) have been suspended with immediate effect.
The notice of suspension was communicated to the Acting Chairman of the anti-graft agency, Mohammed Umar by the Office of the Attorney-General of the Federation.
According to sources, the action was in connection with the ongoing investigation of the suspended Acting Chairman of the agency, Mr. Ibrahim Magu.
What brought anxiety about the situation is that some of those affected were not directly involved in Magu’s administration.
Magu not under out detention, says Police IG
Meanwhile, the Inspector General of Police, IGP Mohammed Adamu, has said that Magu, is not being detained by the Police.
According to Adamu, Magu is being detained by the Presidential Panel investigating the activities of the EFCC.
In a letter written by the Principal Staff Officer to the IGP, DCP Idowu Owohunwa, dated 14th July, 2020, with number CB: 7000/IGP.SEC/ABJ/VOL.489/171 to an application for bail by Magu’s counsel, Tosin Ojaomo Esq, Ojaomo & Ojaomo Chambers, Abuja, the IGP advised that the later be addressed to the Chairman of the Presidential Panel for appropriate attention.


Let me guess, a while ago your garage door started making noises, but it’s still opening and closing fine, so you’re wondering whether you should be concerned…
Well, it all depends on what type of noises it is making, it could be a simple case of lack of lubrication, or it could be a sign that you need to have your garage door serviced before it becomes a more serious issue.
We’ve compiled this handy post to help you identify the kind of noise your garage door is making and to advise you about the steps to take when faced with these noises.
A clunky, thumpy noise when the door opens and closes
This type of sound is normally a sign that the garage door opener is having trouble lifting and lowering the door. This is a problem that you need to investigate.
Have a look over the top of your garage door and check whether one of the torsion spring is broken (double garage doors have two, single garage doors have one). If your one and only torsion spring is broken over your single garage door, the door opener may still be able to open the door, but this does pose a safety risk. It is, however, highly unlikely that both torsion springs on your double door break at the same time.
If you do have a broken spring, you must act without delay! Call a garage door specialist right away and have the situation remedied.
A continuous clinky noise when the door opens and closes
This continuous noise is not as loud as the thumpy noise described above and may be caused by several different things.
In most cases, spring coils have become rusty from the cold, humid atmosphere in the garage, and are rubbing against each other. In other cases, this could be a sign that your roller are defective and need replacing before they fall off.
A constant squeaky noise when the door opens and closes
This sharper sound is usually caused by a lack of lubrication to the exterior frame weather‑stripping and the weather-stripping between garage door sections. These PVC parts can dry out over time and stick together, causing them to squeak.
A grinding noise when the door opens and closes
This unpleasant metal sound is usually related to the chain or belt on your garage door opener, it may be too loose or too tight and needs adjusting.
Can I fix it myself?
It really depends on the issue at hand, if it’s a case of a lack of lubrication, you can buy the right type of lubricant from your local garage door specialist and do it yourself. For metal part, you’ll need to apply a petroleum-based oil to the rollers, hinges and springs; for PVC part, you’ll need to apply a silicone-based lubricant to the weather-stripping at the bottom of the door, between the door sections and around the exterior frame.
Now, if you’re looking at a more serious problem, i.e. a broken torsion spring, you must call a garage door specialist, ideally you want it repairing within 24 hours.
If your door needs any repairs whatsoever, hire a professional. Your door has been calibrated to counterbalance a specific weight and any tinkering around you do with it could throw it off balance and transform your garage door into a dangerous, large moving object that could cause some serious damage.
How often should I have my door tuned-up?
Looking after your garage door is a little bit like looking after your car; it definitely needs tuning-up every 18 months if it’s over five year’s old. If you’re looking for the right person to service your garage door, you’ve come to the right place! As a well-established company, we’re not afraid to guarantee our work. Contact us today at 860-666-9315 to schedule our residential maintenance program. This program includes a 26-point checklist, adjustments and lubrication of your garage door’s main parts, so you can sleep easy knowing your garage door is in good hands. If you prefer, we can email you a quotation. Or you can come down to our showroom to speak to us in person.


text:
The proper golf stance changes depending on what club you are using and get tips on golf stances and foot positions in this free online beginners golf video lesson.
Expert: Ken Portnoy
Bio: Ken holds a Ph.D. from New York University and has been an avid chess player for forty years. He is a rated player and has played and won several chess tournaments.
Filmmaker: ken portnoy


text:
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation of our report dated March 16, 2011 relating to our audit of the consolidated financial statements, the financial statement schedule and internal control over financial reporting included in this Annual Report on Form 10-K, into the Company’s previously filed registration statements on Form S-8 (File Nos. 333-134606, 333-123698, 333-61953, 333-92875 and 333-92877) and Form S-3 (File No. 333-134603).
Hein & Associates LLP
March 16, 2011


text:
Gourmet Chines dining in Nassau, The Bahamas.
Founded in 1988, Cacique International has taken destination management in The Bahamas to a whole new level.
Conchy Joe's offers authentically Bahamian food products.
Green Parrot Bar, Nassau, Bahamas
Sparky's Bar & Martini Lounge, Freeport, Grand Bahama
Prime Bahamas - Wholesale and Retail Food Distribution
Leading grocery chain in The Bahamas.
A private once monthly restaurant catering to Bahamian families and friends with exotic culinary tastes.
Van Breugel's Bar & Bistro, Nassau, Bahamas
Goodfellow Farms, Nassau, Bahamas

domain: food


text:
The impact of the virus pandemic on employment is worse than projected, according to the International Labour Organization.
According to an International Labor Organization (ILO) research released on Wednesday, the number of working hours lost in 2021 due to the pandemic will be substantially higher than previously projected.
The eighth edition of the ILO Monitor: Covid-19 and the World of Work report also warned that the global economy is threatened by disparities in recovery rates between rich and developing countries.
According to the International Labour Organization, global hours worked in 2021 will be 4.3 percent lower than pre-pandemic levels, equating to 125 million full-time employees.
The result is a significant change from the ILO’s June forecast of 3.5 percent growth, or 100 million full-time jobs.
“These trends are being driven by dramatically unequal vaccine distribution and fiscal capacities, both of which must be addressed promptly,” ILO president Guy Ryder told journalists at a UN press conference. “I believe the overarching message… is that this recovery is on the verge of collapsing.”
Without meaningful financial and technical assistance, the ILO cautioned that a “significant disparity” in employment recovery trends between industrialized and poor nations would persist.
The variances, according to the report, are mostly due to significant differences in immunization and fiscal stimulus package deployment.
“Estimates show that in the second quarter of 2021, one full-time equivalent job was added to the global labor market for every 14 people who were completely vaccinated. The ILO stated that this “significantly aided the recovery.” “In the absence of any vaccines, global losses in hours worked would have been 6.0 percent in the second quarter of 2021, rather than the 4.8 percent reported.”
Vaccination coverage is uneven.
According to the ILO, the positive effect of vaccinations was greatest in high-income countries, marginal in lower-middle-income countries, and almost non-existent in low-income countries due to the highly uneven distribution of vaccines.
The report stated, “These disparities could be quickly and effectively corrected with more global solidarity in the area of vaccines.”
Total hours worked in high-income nations fell by 3.6 percent in the third quarter of 2021 compared to the fourth quarter of 2019.
In low-income countries, the disparity was 5.7 percent, while in lower-middle-income ones, it was 7.3 percent.
In terms of geographical comparisons, Europe and Central Asia had the smallest drop-in hours worked – 2.5 percent – compared to pre-pandemic levels.
Asia and the Pacific came in second with 4.6 percent, followed by the Americas with 5.4 percent, Africa with 5.6 percent, and Arab States with 6.5 percent, according to the research.


text:
My name is Lenny. I live in Medicine Hat, Alberta, Canada. I really like Freshpet Vital and Select beef flavour food. I would eat the whole package if they would leave it out.
I like to be called Lenny but Leonard, little (…)”
“Hi there, my name is Charlotte and this is Sam's story. Sam was born 22 November 2005, his mom, Jasmine was Born the 14 of June 2004. They had been eating Iams their entire lives. About six months ago I was told (…)”
“I recently switched to your brand because I couldn't tell if my previous brand was made in the US. My 2 year old yorkie is my 3rd child so I didn't want to take a chance. I was impressed with your ingredient (…)”
“My cat Monet is eleven years old. She is perhaps the sweetest and most intelligent cat I have owned. This spring, I noticed that Monet was losing weight rapidly and seemed lethargic. Monet was diagnosed with Inflammatory Bowel Disease. The vet could (…)”


text: This is probably the longest guide i have ever written. You can tell by the title that this is a guide about Super Smash Bros., a popular video game for the now ancient N64. I spent days testing out moves in order to get the data that appears in this guide. It was hard work but well worth the effort. This guide covers all aspects of Smash, including characters, strategies and techniques. This guide has been overhauled to use a table-less layout in the summer of 2007. Click here to visit.