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- Chair of the RCOG National Clinical Studies group in Reproductive Medicine and Surgery
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Hypoxia-inducible-factor-1α (HIF-1α) and HIF-1 degrading prolyl-hydroxylases (PHD) are key regulators of the hypoxic-inflammatory response. Functionally active genetic variants in the HIF-1α (C/T; Single Nucleotide Polymorphism (SNP) rs11549465) and the PHD2 gene (EGLN1; C/T; SNP rs516651 and T/C; SNP rs480902) are associated with altered HIF-1α mRNA nuclear translocation and an altered adaptation to hypoxia. Furthermore, the HIF system is important in surviving inflammatory disorders and sepsis. Thus, we tested the hypotheses, that SNPs in the HIF-1α or PHD2 genes are (1) common in Caucasians, with 2) the HIF-1α genetic variant being associated with an altered HIF-1α mRNA expression; and 3) independent risk factors for 30-day mortality in severe sepsis.
After ethics approval, 128 septic patients (Caucasian descent) were included prospectively within 24 h after first diagnosing sepsis. Patients characteristics and severity of illness (simplified acute physiology score II), genotypes (Taqman assay), and their influence on leukocyte HIF-1α-mRNA-expression (Real-Time PCR) and 30-day mortality were determined.
Frequencies were 0.8 % for homozygous HIF-1α TT-carriers (CT 17.6 %; CC 81.6 %), 2.5 % for homozygous PHD2 SNP rs516651 TT-allele carriers (CT 17.5 % and CC 80 %), and 9.4 % for homozygous PHD2 SNP rs480902 TT-allele carriers (CT 34.4 % and CC 56.3 %). While HIF-1α T-allele carriers had a borderline decrease in HIF-1α-mRNA-expression (p = 0.06) neither HIF-1α nor PHD2 SNPs were (independent) risk factors for 30-day mortality.
Genetic variants in HIF-1α and PHD2 genes exist in Caucasians but do not appear to alter 30-day mortality in sepsis.
Hypoxia inducible factor-1α (HIF-1) and HIF-1 degrading prolyl-hydroxylases (PHD) are key regulators of the hypoxic response but are also involved in many cellular actions . Furthermore, we could recently show that leukocyte HIF-1α-mRNA-expression is decreased in severe sepsis and inversely correlated with disease severity . Thus, genetic variants in HIF-1 or HIF-degrading PHD2 could impact on HIF-1α mRNA expression and outcome in septic patients.
Recently, functionally active genetic variants in the HIF-1α (C/T; Single Nucleotide Polymorphism (SNP) rs11549465) and the PHD2 gene (EGLN1; C/T; SNP rs516651 and T/C; SNP rs480902) were identified [3–5] and were associated with increased HIF-1α nuclear translocation and a worse outcome compared to the TT-genotype in several tumors . However, the HIF-1-pathway plays an important role in adaptation to inflammation, too, as both HIF-1α mRNA and intracellular HIF-1α protein are highly increased following inflammatory stimuli [7, 8]. With persistent inflammation, HIF-1α is suppressed in vitro and even in patients with sepsis, possibly to counter regulating an overwhelming inflammatory response [2, 7, 9]. Furthermore, the HIF-1α T-allele is associated with an adverse outcome in acute injury of the kidney, i.e. an organ with a HIF-mediated oxygen sensor, important in mediating erythropoiesis [1, 10]. In high altitude populations, the PHD2 variant rs480902 CC-genotype is associated with an increased heart rate and higher oxygen saturation under hypoxia, and PHD2 variant rs516651 T-allele carriers are associated with a decreased incidence of acute mountain sickness . Furthermore, PHD deficiency is associated with an altered inflammatory response, i.e., suppressed cytokine expression in mice .
Taken together, HIF-1α and PHD2 genetic variations are functionally active but their impact on critical illness has not yet been investigated. Accordingly, we examined potential effects of genetic variants of HIF-1 and HIF degrading PHD2, in severe sepsis. Specifically, we tested the hypotheses, that SNPs in the HIF-1α or PHD2 genes are 1) common in Caucasians with 2) the HIF-1α genetic variant being associated with an altered HIF-1α mRNA expression, and 3) independent risk factors for 30-day mortality in severe sepsis.
The study was reviewed and approved by the Medical Faculty’s ethic committee (no. 06-3078, University of Duisburg-Essen, Essen, Germany). Adult patients with sepsis admitted to an intensive care unit of the University Hospital Essen, Germany, between 2010 and 2014 were evaluated for inclusion. Patients were considered eligible when they fulfilled the sepsis criteria as defined by Bone et al. . Patients who refused or withdrew study participation, underage persons, and all individuals with non-Caucasian ethnicity were excluded.
Arterial blood samples were taken for blood tests, microbiology cultures, genotyping, and mRNA extraction within the first 24 h after diagnosing sepsis. Furthermore, SAPS II (Simplified Acute Physiology Score II), length of hospitalization, and 30-day mortality were recorded [2, 13].
The characteristics both of septic patients stratified for either genetic variant are displayed in Table 1 (HIF-1α), Table 2 (PHD2 rs516651), and Table 3 (PHD2 rs480902), respectively.
HIF-1α SNP rs11549465 was genotyped using a commercially available Taqman assay (No.: 4351379; Applied Biosystems; Carlsbad, USA) for the context sequence GTTACGTTCCTTCGATCAGTTGTCA[C/T]CATTAGAAAGCAGTTCCGCAAGCCC. Vector NTI Advance 11 computer program (Invitrogen, Carlsbad, CA) was used to develop primers for genotyping of PHD2 SNPs. The PHD2 (T/C) SNP (rs480902) was resolved using PCR sense primer 5′-TTTTAAAGGAGTGGGGTA-3′ and anti-sense primer 5′-GGTTGTTGGAAATGTAGAAT-3′, while the PHD2 (C/T) SNP (rs516651) was resolved using PCR sense primer 5′-GCAGTTTGACCTGCCAGTTTTGCT-3′ and anti-sense primer 5′-TCTGAAAGGGGTCCAGCAGC-3′. Genotyping was run on a qPCR (Real-Time PCR) System (StepOnePlus™, Applied Biosystem, Carlsbad, USA) at standard conditions (60 °C for 30 min followed by, 95 °C for 10 s, and 15 s at 92 °C and 50 cycles at 60 °C for 1 s).
RNA preparation, qPCR
Whole blood HIF-1α mRNA-expression was analyzed by qPCR following RNA-extraction from the last 62 consecutive patients with severe sepsis included into the study [2, 6]. RNA-extraction was performed on patients’ blood samples using the RNeasy Midi Kit (Qiagen, Hilden, Germany) following manufacturers protocol. One microgram of total RNA was reverse-transcribed to cDNA (complementary deoxyribonucleic acid). As described previously, primers for qPCR were designed using NCBI primer blast (Rockville Pike, MD) and obtained from Invitrogen (Invitrogen AG; Karlsruhe, Germany) .
First, qualitative PCR was performed for GAPDH (glyceraldehyde-3-phosphate-dehydrogenase) as a housekeeping gene to test the quality of cDNA synthesis [2, 14]. Second, quantitative PCR was performed to estimate the amount of specific cDNA for HIF-1α . Resulting cDNA bands were visualized using ethidium bromide-stained 1.5 % (w/v) agarose gels .
HIF-1α mRNA expression was quantified by qPCR using SYBR® green as fluorescent dye (Eurogentec, Verviers, Belgium) on a StepOnePlus PCR system (Applied Biosystems, Carlsbad, USA). The denaturation steps were performed at 95 °C for 10 min, followed by 40 cycles at 95 °C for 15 s, and at 60 or 61 °C for 1 min, as described previously . Amounts of specific cDNA were finally normalized to GAPDH using the ΔΔct method, and results are depicted as 2ΔΔct values, as described .
Data are presented as median with quartiles unless indicated otherwise, and in case of categorical variables as numbers and percentages. Data are presented as means ± standard deviation (SD) unless indicated otherwise. The two tailed t-test for independent samples or, in case of violations of the normality assumption (as tested by Kolmogorov-Smirnov and Shapiro-Wilk tests), the Wilcoxon signed rank test was used. Potential deviations from the Hardy-Weinberg equilibrium were ruled out using Court Lab calculator (Court MH; Court-laboratory Hardy-Weinberg calculator; Tufts University; www.tufts.com) for MS Excel 2011 software (Microsoft Deutschland, Unterschleißheim, Germany).
Furthermore, we investigated associations between the patients’ clinicopathologic characteristics and of the HIF-1α and PHD2 genotypes with 30-day survival, defined as the interval from time of diagnosis of severe sepsis until day 30 or death, whichever occurred first. Patients alive after the 30-day follow-up were regarded as censored. Kaplan-Meier plots were used to display the overall 30-day survival data in the respective subcohorts followed by log-rank tests for comparison of the different genotypes. Thereafter, we computed hazard ratios and 95 %-CI using multivariate Cox regression models to assess the impact of the respective genotypes (HIF-1α and PHD2 rs516651/rs480902), sex, age, Simplified Acute Physiology Score II, and requirement for dialysis as predictors for the clinical outcome (30-day survival). The proportional hazards assumption was checked for all variables included in the models and no deviation was found (data not shown).
An a priori alpha error p of less than 0.05 was considered statistically significant. In case of more than two groups one-way ANOVA with post hoc Student’s t-test and correction for multiple testing (p = 0.05/n) was used. Interdependence between HIF-1α-mRNA-expression and age was analyzed using Pearson correlation and linear regression analysis.
Statistical analyses were performed using SPSS 21.0 (SPSS Inc., Chicago, IL) and Graph Pad Prism 5 (Graph Pad Software, La Jolla, CA) software. Cox regression models were analysed with SAS Version 9.4 PHREG procedure (SAS Institute, Cary, NC, USA).
In this prospective observational trial we included 128 Caucasian septic patients of which 49 (38.3 %) died within 30 days irrespective of genotype.
Frequencies were 0.8 % for homozygous TT-genotypes, 17.6 % for heterozygous CT-genotypes, and 81.6 % for homozygous CC-genotypes (Table 1). 37 CC-genotypes (36.3 %) and 10 out of 22 CT- genotypes (45.5 %) died within 30 days of study inclusion (p = 0.502). For 3 patients, genotyping results were ambiguous, thus patients were excluded from analysis. Kaplan-Meier-graphs (Fig. 1) and multivariate Cox-regression-analyses (Table 4) showed no influence of this genetic variation on 30-day mortality from septic shock. Of note, only a single patient (survivor) carried the homozygous TT-genotype, as shown in Table 1 and Fig. 1. However, this single individual was not included into the statistical analyses.
We then analyzed in 62 samples from consecutive septic patients whether this genetic variant influences HIF-1α-mRNA-expression. Of these patients 17.7 % (n = 11) were T-allele carriers of the HIF-1α SNP rs11549465, and 82.3 % were homozygous CC-genotypes (51 patients). HIF-1α-mRNA-expression was decreased by 62 % in T-allele carriers compared to CC-genotypes (Δct-values: T-allele carriers −8.82 ± 2.1 vs. CC-genotypes −7.45 ± 2.3, Fig. 2) but this was of borderline statistical significance p = 0.06), with CT-allele carriers being older (68 years; Q3; 53–72) than individuals with a CC (54 years; Q1-Q3; 48–66) genotype (p = 0.04). Of note, HIF-1α-mRNA-expression did not correlate with age (Pearson correlation: r = −0.1, p = 0.42), and HIF1-α-mRNA expression did not differ between genotypes even after adjusting for age (data not shown).
Further clinicopathogenic characteristics are displayed in Table 1 and did not differ between groups.
Prolyl-hydroxlase 2 (C/T; rs516651) polymorphism
Frequencies were 2.5 % for the homozygous TT-genotype, 17.5 % for the heterozygous CT-genotype, and 80 % for the homozygous CC-genotype (Table 2). 33 CC-genotypes (34.4 %), 8 CT- genotypes (38.1 %) and 2 TT-genotypes (66.7 %) died within 30 days of study inclusion (p = 0.103). For 8 patients genotyping results were ambiguous, thus patients were excluded from further analyses. Kaplan-Meier-curve analysis (Fig. 3) and multivariate Cox-regression-analysis (Table 5) showed no influence of this genetic variation on 30-day mortality from septic shock. Patients clinicopathogenic characteristics did not differ between groups (Table 2).
Prolyl-hydroxlase 2 (T/C; rs480902) polymorphism
Frequencies were 9.4 % for the homozygous TT-genotype, 34.4 % for the heterozygous CT-genotype, and 56.3 % for homozygous CC-genotype (Table 3). 27 CC-genotypes (37.5 %), 18 CT- genotypes (40.9 %) and 4 TT-genotypes (33.3 %) died within 30 days of study inclusion (p = 0.876). Kaplan-Meier-curve analysis (Fig. 4) and multivariate Cox-regression-analysis (Table 6) showed no influence of this genetic variation on 30-day mortality from septic shock. However, the adjusted hazard ratio for mortality was 1.39 (95 %-CI 0.47–4.10) for CC vs. TT genotypes and 1.8 (95 %-CI 0.58–5.59) for CT vs. TT genotypes, suggesting a slight increase in 30-day mortality. Patients’ clinicopathogenic characteristics did not differ between groups (Table 3).
In this prospective study we show, that allele frequencies in Caucasian for the functionally active SNPs of the hypoxic-inflammatory response, namely HIF-1α SNP rs11549465, PHD2 rs516651 and rs480902 highly differ from Asian ethnicities. However these SNPs did not have a major impact on 30-day mortality in patients with severe sepsis in our sample. Of note, HIF-1α-mRNA-expression showed a trend towards lower expression in HIF-1α T-allele carriers.
HIF-1α SNP frequencies in our Caucasian cohort with sepsis revealed only a single homozygous TT-genotype carrier (0.8 %), whereas 17.6 and 81.6 % carried the heterozygous CT- and homozygous CC-genotypes, respectively. Notably, in people from India the TT-genotype is common with a frequency of 25 %, and 50 % CT-genotypes. T-allele carriers show an association with worse outcomes in metastatic prostate cancer or acute kidney injury [3, 15]. In this prospective study we could not confirm an influence of this SNP on 30-day mortality from severe sepsis. While this might relate to the very low frequency of homozygous TT-genotype carrier in our cohort, 30-day survival also did not differ between HIF-1α CT- and CC-genotypes.
However, HIF-1α mRNA expression showed a trend towards lower expression in T-allele carriers and on average was decreased by 62 %. As we reported previously, decreased HIF-1α mRNA expression inversely correlates with sepsis severity, i.e., with greater HIF-1α mRNA expression and intracellular HIF-1α protein suppression in patients with higher Simplified Acute Physiology Score II (SAPS II) . As a high SAPS II is associated with increased mortality, one might expect increased mortality in HIF-1α T-allele carriers as well, however one might emphasize that sepsis itself contributes stronger to alterations in HIF-1α mRNA expression than this genetic variant does . However, sepsis is a heterogeneous disease with multiple factors contributing to the patients’ mortality. Even, in our previous study HIF-1α mRNA-expression correlated with disease severity but not with outcome .
In a next step we analyzed genetic variants in the HIF-1 degrading PHD2 gene, as these SNPs are associated with an increased oxygen saturation and heart rate in response to hypoxia and thus improved adaptation . Furthermore, a PHD2 knockout in mice inhibits TNFα and ICAM-1 expression with reduced cell apoptosis and macrophage infiltration . Furthermore, inhibition of PHD2 attenuates cardiac dysfunction in mice undergoing a high fat diet by a mechanism involving suppression of the MYD88/nuclear factor Kappa B inflammatory pathway . Thus, functionally active genetic variants in the PHD2 gene could also impact on patients outcome in severe sepsis, e.g., by altering the inflammatory response.
Therefore, we determined the genotype frequencies of PHD2 SNP rs516651 carriers in our Caucasian cohort, with homozygous TT- genotypes found in 2.5 % of septic patients and heterozygous CT-genotypes in 17.5 %. Thus, we show that this SNP is present in Caucasians whereas in Tibetan high altitude residents, T-allele carriers do not exist . Given this distribution in Caucasians, the PHD2 SNP rs516651 turned out not to be an independent predictor for 30-day mortality in a multivariate Cox-regression analysis including common known risk factors for sepsis mortality in our rather small patients cohort.
The PHD2 SNP rs480902, was common in Caucasians as well, however frequencies for homozygous TT-genotypes (9.4 %) and CT-genotypes (34.4 %), were lower when compared to Tibetan high altitude residents with frequencies of T-allele carriers of up to 75 % .
However, the PHD2 SNP rs480902 genotype did not impact on 30-day mortality. PHD2 is a key-regulator of HIF-1α in erythropoietin producing cells and, therefore, crucial for regulation of erythropoietin secretion . In mice, PHD2 deficiency leads to pronounced erythrocytosis due to a suppressed HIF-1α degradation and hence activation of the erythropoietin pathway,  as well as to increased angiogenesis . Whereas regulation of erythrocytosis usually represents monocausal mid to long-term changes, severe sepsis is an acute life-threatening disorder depending on many issues. This might explain why PHD2 genetic variants did not impact on survival in our cohort.
Our study has limitations: First, given the low genotype frequencies for the homozygous HIF-1α and PHD2 rs516651 TT-genotype, 128 septic patients still need to be considered a small sample, reducing the explanatory power of our analysis. Thus, reanalyzing the influence of HIF-1α and PHD2 SNPs in a larger cohort of septic patients is warranted. Furthermore, in this study we did not analyze the impact of either genetic variant on the patients phenotype i.e. regarding immune cell function or blood coagulation. This is of particular interest as other genetic variants, i.e. the NFKB1 promoter polymorphism -94ins/delATTG, turned out to be an independent predictor for 30-day mortality from septic shock, in a similar patients cohort of 143 patients . In detail, the Deletion-allele was associated with altered blood coagulation and hyperinflammation . Second, due to ethics issues and restrictions we only could analyze HIF-1α mRNA expression from the last 62 consecutive patients only at one time point. Analyzing HIF-1α mRNA expression in the course of sepsis depending on genetic variants might help to understand the regulation of the hypoxic-inflammatory pathway in the critically ill. More important, leukocyte HIF-1α mRNA expression was suppressed in T-allele carriers when compared to the CC-genotype, but this failed to reach statistical significance (p = 0.06). However, such variations in HIF-1α mRNA expression in T-allele carriers, are in accordance with the large variation of leukocyte HIF-1α expression in septic patients,  as well as a worse outcome of T-allele carriers with metastatic prostate cancer . Third, septic patients are a very heterogeneous cohort due to various entities of sepsis or comorbidities. Thus, it might be favorable to analyze these polymorphisms in a cohort with a more homogenous sepsis entity, e.g., in patients with acute respiratory distress syndrome.
In conclusion, genetic variants in HIF-1α and PHD2 genes exist in Caucasians. However, homozygous TT-genotypes are infrequent and range from 0.8 % for HIF-1α SNP rs516651 to 9.4 % for PHD2 SNP rs480902. Furthermore, even in our rather small sample, T-allele carriers of the HIF-1α SNP show a trend towards further suppressed HIF-1α mRNA expression compared to CC genotypes. However, neither of the analyzed genetic variants of HIF-1α and PHD2 genes turned out to be independent risk factors for 30-day mortality of severe sepsis. Reanalyzing the influence of these genetic variants in a larger and more homogenous patients cohort i.e. patients with Acute respiratory distress syndrome (ARDS) is warranted to confirm the findings of our study.
Fraga A, Ribeiro R, Príncipe P, Lobato C, Pina F, Maurício J, Monteiro C, Sousa H, Calais da Silva F, Lopes C, Medeiros R. The HIF1A functional genetic polymorphism at locus +1772 associates with progression to metastatic prostate cancer and refractoriness to hormonal castration. Eur J Cancer. 2014;50:359–65.
Pichu S, Sathiyamoorthy J, Krishnamoorthy E, Umapathy D, Viswanathan V. Impact of the hypoxia inducible factor-1α (HIF-1α) pro582ser polymorphism and its gene expression on diabetic foot ulcers. Diabetes Res Clin Pract. 2015;109:533–40.
Buroker NE, Ning X-H, Zhou Z-N, Li K, Cen W-J, Wu X-F, Zhu W-Z, Scott CR, Chen S-H. EPAS1 and EGLN1 associations with high altitude sickness in Han and Tibetan Chinese at the Qinghai–Tibetan Plateau. Blood Cell Mol Dis. 2012;49:67–73.
Lessi F, Mazzanti CM, Tomei S, Di Cristofano C, Minervini A, Menicagli M, Apollo A, Masieri L, Collecchi P, Minervini R, Carini M, Bevilacqua G. VHL and HIF-1α: gene variations and prognosis in early-stage clear cell renal cell carcinoma. Med Oncol. 2014;31:840.
Frede S, Berchner-Pfannschmidt U, Fandrey J. Regulation of Hypoxia-Inducible Factors During Inflammation. In Methods in Enzymology. Volume 435. Amerstdam: Elsevier; 2007:403–419. [Methods in Enzymology] http://dx.doi.org/10.1016/S0076-6879(07)35021-0.
Frede S, Stockmann C, Freitag P, Fandrey J. Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB. Biochem J. 2006;396:517–27.
Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ, ACCP/SCCM Consensus Conference Committee. Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;136:2009.
Winer J, Jung CK, Shackel I, Williams PM. Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem. 1999;270:41–9.
Kolyada AY, Tighiouart H, Perianayagam MC, Liangos O, Madias NE, Jaber BL. A genetic variant of hypoxia-inducible factor-1α is associated with adverse outcomes in acute kidney injury. Kidney Int. 2009;75:1322–9.
Percy MJ, Zhao Q, Flores A, Harrison C, Lappin TRJ, Maxwell PH, McMullin MF, Lee FS. A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis. Proc Natl Acad Sci U S A. 2006;103:654–9.
Adamzik M, Schäfer S, Frey UH, Becker A, Kreuzer M, Winning S, Frede S, Steinmann J, Fandrey J, Zacharowski K, Siffert W, Peters J, Hartmann M. The NFKB1 promoter polymorphism (−94ins/delATTG) alters nuclear translocation of NF-kB1 in monocytes after lipopolysaccharide stimulation and is associated with increased mortality in sepsis. Anesthesiology. 2013;118:123–33.
We want to thank Ursula Brecklinghaus, MTA and Baerbel Hermann, MTA for the great support regarding genotyping and qPCR.
The study was funded by departmental resources as well as a research grant given to PD Dr Schaefer from the medical faculty of the university hospital Essen (IFORES research grant no: D/D107-40240). However, the authors declare that they do not have any competing interests, i.e. the reasearch grant given from the Medical Faculty of the University Duisburg-Essen to PD Dr. Simon Schäfer did not affect study design; data collection, analysis, interpretation of data, writing of the manuscript or the decision to submit the manuscript for publication.
Availability of data and materials
All relevant data and materials are presented in the manuscript.
HA, SST, and PJ conceived and conducted the study. HA, RM, EA, BHS, and WK designed primers, and established and performed the genotyping. BA, KM, and CL performed mRNA extraction and qPCR. HA, BA, and STS analyzed the data. EL and JKH provided statistical analyses. SST and PJ provided experimental experience and revised the manuscript. All authors read and approved the final manuscript.
PD Dr S. Schaefer’s current working address is Klinik für Anaesthesiologie, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Marchioninistraße 15, 81377 München.
The authors declare that they have no competing interests.
Consent for publication
Written informed consent was obtained from the patient or the patients guardian. Patients who refused or withdrew study participation, underage persons, and all individuals with non-Caucasian ethnicity were excluded.
Ethics approval and soncent to participate
The study was reviewed and approved by the Medical Faculty’s ethics committee (no. 06–3078, University of Duisburg-Essen, Essen, Germany).
Authors and Affiliations
Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen and Universität Duisburg-Essen, Hufelandstraße 55, D-45122, Essen, Germany
Annika Höcker, Miriam Rabeling, Alexandra Bick, Linda Cox, Maximiliane Kreuzer, Andrea Engler, Kai Walstein, Michael Adamzik, Jürgen Peters & Simon T. Schäfer
Institut für Pharmakogenetik, Universitätsklinikum Essen and Universität Duisburg-Essen, Essen, Germany
Hagen S. Bachmann
Institut für Medizinische Informatik, Biometrie und Epidemiologie, Universitätsklinikum Essen and Universität Duisburg-Essen, Essen, Germany
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Höcker, A., Rabeling, M., Bick, A. et al. Hypoxia inducible factor-1 alpha and prolinhydroxlase 2 polymorphisms in patients with severe sepsis: a prospective observational trial.
BMC Anesthesiol16, 61 (2015). https://doi.org/10.1186/s12871-016-0225-y

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text:
The RWP-024-3XR is a 0.75″ dovetail bridge system for milling applications. This product is designed for modular applications: utilizing three RWP-024 fixtures in-line to hold longer parts.
The versatility of this fixture allows you to either hold three workpieces weighing 8 pounds and size (L x W x H) 2.0″ x 2.0″ x 2.0″ or 1 long workpiece weighing up to 24 pounds and size (L x W x H) 12.5″ x 4.0″ x 4.0″.
The components of the RWP-024-3XR (each RWP-024 and base unit) are manufactured from Aluminum 7075-T6511 and Anodized Class 2 Type II.
The fixture clamps are made from 17-4 Stainless Steel.
The bridge system is sold complete as shown. *Base unit can be purchased separately if you already own the RWP-024. Please call for details and availability.
Raptor Dovetail Fixtures are made to hold your part on four and five-axis CNC machines. The fixtures provide rigid clamping while exposing five faces of the workpiece. Most features can be completed in a single operation. Our unique Raptor Dovetail spring-loaded clamps require only 1/8″ of material to hold the workpiece. That means less waste, easier prep and no distortion. You prepare all your parts with a single dovetail and utilize the same fixture for every part. Easy, strong and efficient.

domain: design


text:
County Library Events
Bring the whole family to enjoy fun stories and activities that foster reading readiness and listening skills.
For children of all ages. Younger children will need caregiver assistance
Mon, March 5, 2018
Other Dates For This Event:
Browse by Day


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ATTEMPTED CHILD ABDUCTION !!!
Motorists in the White River
Township area likely to notice many unmarked cars, marked cars, and motorcycles in
the area of the Hickory Stick Subdivision. A multitude of Detectives, Sheriff's Deputies' and other law enforcement officers
are cruising the area observing for the suspect in two attempted child abductions.
The Johnson County Sheriff's
Office is investigating two reports of attempted child abductions in the Hickory
Stick Subdivision located at Whiteland Road and Morgantown Road in White River
Township, Greenwood, Indiana. On September 20, 2004, the Sheriff's Office
received the reports of attempted abductions that occurred on September 9th and
September 13th 2004.
The description of the suspect and
suspect vehicle are similar in both incidents: The suspect is described as
having a dark complexion with a mustache. He is operating a newer white
van (possibly a minivan) with dark tinted windows.
In the incident on the 9th during
the afternoon hours, a six-year old boy was confronted by the suspect and was
asked if he wanted some ice cream. The boy yelled for his mother and the
suspect left the area.
In the incident on the 13th, the
suspect asked a five-year old boy if he needed a ride home then the suspect left
The Sheriff's Office requests the
assistance of the motoring public to be on the lookout for this vehicle and
suspect in the White River area of Johnson County. The Sheriff's Office is
investigating the possibility that this incident is linked to other similar
incidents in other jurisdictions.
If you observe a matching suspect
and suspect vehicle that is suspicious, please call 9-1-1 immediately. Do
not delay. If you have general information that may be of assistance in
this investigation, please e-mail
AsktheJCSO@johnsoncountysheriff.com or call the Crime Tip Hotline at
317-736-2204. Individuals are reminded to never approach the suspect of a
crime; Simply contact local law enforcement immediately to handle the situation.

domain: news


How to Make Sure Your Children’s Toys are NONTOXIC
Children’s toys are amongst the last places you’d expect to find toxic chemicals. After all, we know kids are even more susceptible to many hazardous substances than adults are. Unfortunately, there are still plenty of toxic materials that can end up in your child’s toy chest.
In reality, not every toy is made equal- while some are perfectly safe, some toys contain chemicals that can cause serious harm. In this article, we’ll explore how to be certain that your children’s toys are not exposing them to dangerous chemicals.


text:
Nokia on track to closing Symbian deal by year-end
Nokia’s 264 million euro offer to buy Symbian is on track, says chief development officer Mary McDowell, and should be in wrap-up mode by this year’s end.
The offer to acquire the last remaining shares of Symbian that still weren’t theirs was made by Nokia back in June. Since then, a number of other electronic companies have joined the original 10-member org to form the Symbian Foundation.
For Nokia, members of the Symbian Foundation, and the open-source community, this is a great development. Indeed, since Nokia plans to roll out the first devices powered by the Symbian Foundation’s OS as early as 2010, the deal should be settled even more earlier.
McDowell also hints that Nokia may reinforce their suite of Internet services, further commenting, “Clearly Internet services represent a revenue growth opportunity, (but it is) also a basis of competition in high-end devices.”
So, powerful, internet-enabled, and high-end, is probably what we can expect from Nokia and the Symbian Foundation in the future.


The Ultimate Guide To wheel alignment near 60402If your front is small and you have detrimental camber, then your springs are suspect. The upper arm can help with alignment but won't
It is a tough task to perform on your own without having a push, mainly because it's a good in shape obtaining the bearing in and out of the hub. It really is less perform (though much more expense for sections) to replace The full hub and bearing for a unit.
For those who changed the wheel bearing plus the noise remains there, It truly is achievable the CV joint/Axle is earning the sound. In case you hear the sounds on tight turns and though accelerating, more than likely it's the CV joint. I'm unsure on the price, labor ought to be around 2 hours in addition the parts.
Hitting a pothole can cause damage to your tires, suspension method as well as your engine. Here’s how to deal with these hazardous holes. Go through the total report >
Purchaser invoice #**. Stopped in the Firestone location at forty nine Faunce Corner Rd in N. Dartmouth, MA to repair a rear passenger tire with 15lbs of air. The auto was introduced in and also the technician took apart the appropriate front passenger tire and supposedly repair the tire. When I went to driveaway I decided to begin to see the position and my ideal rear tire was however pretty very low.
Lock and cargo Off road was formally Launched in December of 2012. Everything started with a a gaggle of fans brought with each other by our appreciate of Jeeps and produced good friends by a multitude of other hobbies, our sturdy aid from the 2nd Modification rights, as well as considered that an apocalypse (zombie or in any other case) would need a bit of planning to properly navigate.
You are able to do the 3/4 kit and however Have got a inventory trip! And your wheels really should function fine also (as long as These are the correct offset). You will notice a noticeable fall but not be slammed on the bottom, you can drive “Typically”, get ordinary tire have on, and seem good! Mail us a picure.
I'm a business driver and need a lot of Focus on my automobile. I received an oil alter at Conrad's they usually told me that my electricity steering fluid was leaking. I went and experienced it checked out at Firestone in Avon and John the company manager explained to me that he can perform a dye exam, which I never ever realized something about.
The clicking is coming from something which is rotating so I like to recommend examining your tire for nearly anything caught in it, the rotor and also the CV joint boot for virtually any leaking grease. If it is leaking grease, you'll need to possess the axle replaced.
Our solutions are extremely acknowledged for their quick program managing and we offer these products in various technical specs backed by excellent immediately after sales area solutions throughout india.
I will acquire this yet again and may endorse it to anybody trying to find new tires. The tires new are pricey but ultimately you obtain what you buy. Continue to keep All your family members Safe and sound whilst to the highway and choose Firestone. You won't regret it Over time. I will not likely use another tires once more.
Many thanks for receiving back! I don’t wish to discourage you out of your strategy. My ideas had been to give you a heads up on probable difficulties Which may excursion you up. Location in my space right here without having Home windows I've a tough time observing precisely what your taking a look at, don’t let me chat you out of one's approach! You by now understand that using the manufacturing facility shackles in the rear with the flip package gives you a 6 inch drop and if you wish to go lower just install a pair of 2″ shackles using The within holes for that 7″ fall. In regards to the front you are absolutely correct about the “heater hose” trick.
No, unlikely, With this kind of slight vibration you can attempt having the wheels balanced, but you may well lead to a vibration at a distinct speed. Let me know what you decide.
Of course and Certainly. Most probably you weakened the wheel bearing, and now there is a humming noise; an axle will be extra of vibration on acceleration or clicking on acceleration when turning from a read this cease.


This paper presents a computational parametric study of evaporation processes in liquid-fueled, simulated porous media burners using a two-energy equation model. The effects of porous medium heat source, porous medium structure, fuel flow rate, and air inlet temperature on evaporation characteristics were determined. Predicted steady-state axial temperature profiles within the porous media and radial vapor concentration profiles at 5 cm downstream of the porous medium are presented. Vapor concentration results showed a strong dependence on porous medium temperature, which, in turn, depended on the strength of the heat source and the effectiveness of heat transfer between porous medium and coflow air. Simulations with different porosities demonstrated that the peak vapor concentration decreased as porosity increased. The peak vapor concentration dropped by 42 % when porosity was increased from 0.5 to 0.87. Under higher fuel flowrate conditions, the extent of completeness of evaporation decreased, showing that much stronger heat source was needed to maintain the complete evaporation. When the coflow air temperature was increased, the peak vapor concentration was found to increase and the vapor concentration spread more radially.
A Parametric Simulation of the Evaporation in Liquid-Fueled Porous Burners
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Periasamy, C, & Gollahalli, SR. "A Parametric Simulation of the Evaporation in Liquid-Fueled Porous Burners." Proceedings of the ASME 2006 Power Conference. ASME 2006 Power Conference. Atlanta, Georgia, USA. May 2–4, 2006. pp. 409-415. ASME. https://doi.org/10.1115/POWER2006-88016
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text:
Led by Beijing Olympics gold-medallist Abhinav Bindra, there are 17 shooters from among 45 athletes, who have been selected by the government for financial assistance under the Target Olympic Podium (TOP) scheme.
The WB and India have
concluded negotiations for loans worth USD 3.2 bn for
recapitalising state-run banks and funding for the India
Infrastructure Finance Company Ltd, a state-run lender to

domain: economics


text:
Imagine a surreal view where you feel like you are walking on the clouds. Welcome to the famous “Sea of Clouds” (unkai), located on Mount Tomamu in Hokkaido!
Such a magnificent view is usually the privilege of hikers, but for the past 10 years, this resort located in the heart of the island of Hokkaido has offered it to you in just 13 minutes of climbing.
The terrace is part of Hoshino Resorts Tomamu station located in Yufutsu district. A family resort open all year round, famous for its slopes and powder snow.
In addition to skiing and snowboarding, vacationers can enjoy a multitude of “off-season” activities, such as horseback riding and hot air ballooning. But the highlight of the show remains this grandiose natural phenomenon.
By using the chairlifts intended for skiers during winter, nature lovers will have to climb quietly for 13 minutes, in order to reach the top and enjoy this atypical place.
Last fall, the terrace welcomed its 100,000th visitor since it opened in 2006.
Although the terrace is located at the top of the chairlift (1088 meters above sea level), it is located approximately 150 meters below the summit.
This “sea of clouds” is a phenomenon which depends both on the terrain and on climatic conditions. Tomamu means “wetlands” or “bogs” in the Ainu language.
Your chances of seeing the unkai are around 30 to 40% during the period when the terrace is open. Fortunately, the time and probability of the phenomenon appearing are indicated on the official website available in English.
While you’re at it, why not grab a hot drink or snack in the adjacent café to warm up, or join a yoga class?
Another funny anecdote: the entrance ticket is actually a postcard, and you can send it from the terrace for free.
The terrace is open every morning from 4 to 8 a.m., from May 14 to October 17 and around noon from July 23 to August 31. Count ¥ 2200 (€ 18.80) for admission.

domain: travel


text:
A delicious salad from Siracusa in Sicily using our Coppa and Bresaola
This is a recipe from Padstow Kitchen Gardens. It's based on a delicious salad from Spizzica, a restaurant in Ortigia, Siracusa in Sicily.
Spread a third of the salad leaves onto a plate and top with a slice of bresaola, coppa and two chunks of mozzarella. Create a layered effect by adding more leaves and drizzle with olive oil. Repeat the layering process, finishing with leaves on top. Finally, drizzle with a tablespoon of lemon juice and more olive oil, salt and pepper and some shavings of parmesan.

domain: food


In order to deploy an application that uses TX Text Control for Angular, a WebSocketServer must be hosted and the synchronization TCP Service needs to be installed on a Windows Server machine. The client-side component opens a WebSocket connection to the WebSocketHandler running within the WebSocketServer.
The server that hosts your client-side application can be deployed to all platforms including Windows, Linux and Mac. The backend can be implemented using the TX Text Control .NET Server for ASP.NET running on IIS on a Windows Server or Docker Container.
To use TX Text Control for Angular in production, you will have to acquire developer licenses for the product TX Text Control .NET Server for ASP.NET.
The backend includes:


text:
By Michael Odeng
DOMESTIC darts lovers and their counterparts from the rest of East African region are expected to focus their attention to Kampala on Friday as the city is slated to host the Uganda International Darts Open Championship.
Uganda Darts Association (UDA) has organized the tournament in its continuous efforts to revive and promote the sport at domestic level, apart from fostering better relations among darts players in the region.
However, Ugandan players are determined to put up a spirited performance in the coming tournament to be held at Platinum Royale Hotel in Busega, a Kampala suburb.
The two-day championship that is expected starts on Friday will attract a number of national teams and clubs from the East African region like Kenya, Tanzania, Burundi and Rwanda. Over 100 players are expected to battle it out at the event.
The championship will involve singles, doubles and team game and plenty of prizes have been set aside for winners of the tournament.
The Inspector of Prisons, Patrick Akena, who will be one of the participants in the tournament urged Uganda dart players to continue training intensively for the championship so that all prizes remain in Uganda.
“Our eyes will be on the top prize and this can only be achieved through intensive training and early preparation for the tournament,” Akena added.


.22 Rimfire Shooting Targets for Sale
Start with MGM durability and top-of-the-line materials combined with uniquely designed targets for .22 caliber rimfire ammunition and your imagination is the limit! The MGM .22 Rimfire series – Autopoppers, Plate Racks, Spinners, and the newest – MGM .22 Football Target all bring unmatched appeal, quality, and value to your .22 shooting enjoyment.
MGM HexPlate™: MGM’s exclusive HexPlate™ hexagonal-shaped targets are made of premium MGM AR400 or HEXALLOY 550 steel. The hexagonal shape offers up to 13% more target area than the same size round plate, and everyone will see the immediately recognizable MGM hex logo shape and know it as a genuine MGM Targets product, synonymous with quality, reliability, and value. Leave Nothing To Chance™.


text:
But for many unauthorized immigrants, there isn't a viable pathway to come to the U.S. legally. And being in the country without legal status can be a civil violation, the criminal law equivalent of a parking ticket. No one would say that a parking ticket would lead to someone becoming a violent criminal.
Of course, that immigrants appear less likely to commit crimes is poor consolation for someone who has lost a loved one.
Joshua Wilkenson's mother, Laura, spoke to ABC-Univision about her son's murder on Monday. She doesn't believe Joshua's killer did it because of his immigration status, but she can't escape the basic fact that the crime could have been prevented if immigration laws had been better enforced.
"Josh was murdered through no fault of his own; he went to school one day," she said. "If the kid hadn't been here, he'd be alive today."
But when it comes to setting public policy, we need to make logical, informed choices using data, and not solely emotion and personal stories.

domain: sociology


text:
Observation of the cancer patient journey: a learning curve for Genetic Counsellors
© Taylor and Mann; licensee BioMed Central Ltd. 2012
Published: 12 April 2012
Cancer genetic counsellors typically work in hospitals and participate in multidisciplinary clinical teams. However, in their training, genetic counsellors seldom have much exposure to the medical environments in which their clients receive their cancer treatment. Although there is a general understanding about screening, learning a diagnosis, surgical, chemotherapy, and radiotherapy treatments, many of the genetic counsellors have no first hand experience of these processes, making it difficult to comprehend the impact it has on clients.
This project aimed to develop knowledge and awareness of what a cancer patient would experience throughout their cancer journey, therefore increasing the scope for empathy and consideration for clients seen. Secondly, this project aims for genetic counsellors to gain a better appreciation of the risk management procedures and surgeries that enter into the genetic counsellor's discussions with clients of a Familial Cancer Centre (FCC).
Two genetic counsellors approached several senior clinicians (including Medical Oncologists, Gastroenterologists, Surgeons, and Gynaecologists) affiliated with the Royal Melbourne Hospital FCC to observe both consultations and medical procedures in their speciality area.
The genetic counsellors reflected on their observations of the patient's cancer journey and how the patient's experiences may impact on a genetic counselling session. Both counsellors gained a greater insight into the enormity of a cancer diagnosis on an individual.
We wish to share our experience: a greater knowledge of the screening and surgical recommendations that are discussed in a genetic counselling session, an increased awareness of the role of other medical professionals in the patient's cancer journey and a better understanding of how the FCC integrates with the patient's cancer journey. This project warrants extension as we believe that by being better equipped to understand our patients and their needs, we can provide better patient care.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

domain: health


text:
Gomoa Abonyi, (C\R), May 12, GNA – The Programmes Director of Compassion International Ghana, Mrs Florence Sena Amponsah, has warned adolescent girls to desist from illegal abortion and pre-marital sex to avoid unwanted babies and birth complications.
She said it was sad that some young girls indulged in premarital sexual issues that had resulted in teenage pregnancies and others social problems on families.
Mrs Amponsah gave this caution when she addressed a two-day Youth Rally for 2,000 beneficiaries of Agona Swedru cluster of Compassion International Ghana at Gomoa Abonyi.
The Programmes Director said research had revealed that majority of teenagers both girls used contraceptives some of which were harmful.
She advised the teenage boys to also refrain from early sex as it affected their adulthood, adding that it could truncate of their education.
She said biblically, sex before marriage was termed as fornication which was sin against God and cautioned teenagers to stop early sex and concentrate on their education and urged parents and guardians to take proper care of the children and avoid spending extravagantly on funerals.
Mr Padmore Baffour Agyapong, Country Director of Compassion International Ghana disclosed that 71,000 Children had been registered under the care of Compassion throughout the country.
He said this year, fresh registration of children would be carried out nationwide especially for the under privileged in the areas of education, clothing and healthcare.
He urged the youth to use their time to read their text books and avoid frivolous internet engagements.
Mr Agyapong cautioned that Project Coordinators against squandering monies meant for the upkeep of the beneficiaries.
He said Compassion International Ghana had realised that majority of Ghanaian children were living in abject poverty and needed be salvaged. GNA


text:
A research project by Cardiff Metropolitan University aimed at helping to inspire a new generation of innovation policy, funding and growth in Wales is looking for businesses to take part in their quick online survey.
It seeks to explore the innovation activity of Welsh medium-sized enterprises (50-249 employees). Its main focus is on the Convergence Zone, which covers the Unitary Authorities of Blaenau Gwent, Bridgend, Caerphilly, Carmarthen, Ceredigion, Conwy, Denbighshire, Gwynedd, Isle of Anglesey, Merthyr Tydfil, Neath Port Talbot, Pembrokeshire, Rhondda Cynon Taff, Swansea and Torfaen. However, input from all areas of Wales will be included.
Funded through the European Social Funding, the study provides a state-of-the-art exploration of the innovation environment in Wales. Findings of the study could potentially influence innovation funding, policy and practice within Wales.
Your response can help shape this future, so if you are involved in innovation at either a strategic or operational level please complete the survey at the following link.

domain: geography


Hollis‘s Explorer rebreather has created a unique place in the market.
Tad Masek, Senior Design Engineer for Hollis, told DeeperBlue.com at DEMA Show 2015 this week in Orlando:
“Its direct competition isn’t other rebreathers, its other open circuit systems.”
The simple user interface, and the ability to get up and running safely and quickly set this unit in its own class, it operates off a single cylinder of Nitrox which can do a 32-40 percent mixture, making it possible to take it basically anywhere in the world and still get air fills.
All of the major training agencies offer courses to get certified on the system, usually within a weekend. The maximum depth range is 120 feet, but once you are familiar and ready for more frontiers Hollis offers full capability rebreathers to take you anywhere you want to go.
Safety features include a built-in, bailout valve on the mouth piece; flip the switch if there is any sign of a problem, and you are back to breathing regular open-circuit directly from the nitrox cylinder. Multiple other redundant safety systems have also taken the guesswork out of rebreather diving.
Scott Cooper has been instrumental in the rollout of the Explorer into the recreational market. His passion is to bring the joy associated with the best parts of the rebreather experience industry wide, “to allow a more intimate relationship between divers and the ocean.”
For everyone from brand new divers to the very experienced, it dramatically improves the experience of being underwater by allowing the diver to become part of the environment; allowing fish and other aquatic life to interact more closely with you.
Hollis is of course also offering a complete line of gear for every type of diving. The harness system that the rebreathers mount to can also be used for traditional scuba cylinders. All of the products share American made quality and engineering based on a rich history in diving. This year they also have a 2-piece full-face mask in the booth from Kirby Morgan that is worth checking out at DEMA Show this year.


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Gold-Dipped Blue Pinch Bowls (Set of 2)
+ $ shipping surcharge
There for you in a pinch.
Make your sauces and snacks feel downright royal with these lustrous French blue and gold dipped bowls. Pull them out and fill them with little dainties to make any impromptu caller feel welcome, leave them beside the sink to catch jewelry, fill them with salt or condiments for the table, all while bringing petite gleams of color into your home.
Note: The color of the glaze may vary slightly from batch to batch. Due to the handmade nature of these items, the color may differ slightly from what is pictured.
Photography by Bobbi Lin and Rocky Luten
Details & Materials -
Brooklyn, New York
White stoneware with food safe glaze and gold lustre
4" in diameter x 1 to 1.5” H, though they may vary slightly in size as they are handmade.
Care & Notes -
Meet the Maker
Kim Gilmour grew up in rural New Hampshire -- the inspiration for her pottery comes from the beauty and imperfection of the natural world. After moving to Brooklyn and starting to work with pottery, she decided to open her own shop. Each piece is organic and abstract, but also a completely functional piece of pottery. Each piece is either hand-built, thrown on an electric wheel, or is a combination of both.View Full Profile
Our Tips & Stories
How we'd use this beauty in our own homes.
From pantry to present in no time at all.
These cookies go by many names—we just call them delicious.
Bold, buttery bites from a longtime community member.
A Similar Style
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domain: artistic


text:
Czerny and Keller1 mention that Mesnil found sugar occasionally in the urine of infants during the first few days of life, and Nothman2 found sugar in the urine of premature infants. The presence of sugar was shown by reduction tests, and in the case of Nothman the osazone was prepared which indicated the presence of lactose. By using the Benedict-Osterberg3 method, Greenthal4 showed that the urine of all infants contains sugar. This would be expected from the results obtained by Benedict, Osterberg and Neuwirth.5 These authors found determinable quantities of sugar at all times, both in the urine of normal dogs, and those fasting for four-day periods, and in the urine of adults.
Thanks to the kindness of Dr. Sauer, we were able to obtain the urine of a series of new born infants for sugar determination.
The urine was collected during the period preceding
MILLIKIN F. THE PRESENCE OF SUGAR IN THE URINE OF NEW BORN INFANTS BEFORE THE INTAKE OF FOODS. Am J Dis Child. 1921;21(5):484-487. doi:10.1001/archpedi.1921.01910350071009

domain: chemistry


text:
With the 9-5 work day on its way out, a new, flexible leadership strategy is more important than ever. Most Australians check their work emails outside of work hours. So how does the line blurring between work and play affect the workplace of the future?
Workspaces are undertaking a major transformation as we move to the future. The 9-5 work day is on its way out. The line between work and play is becoming increasingly blurred. And workplace culture is dramatically changing as the new generation of millennials take over the workforce.
So how will this affect you and your business?
Anyone who has been in a leadership position will have faced the prospect of “managing the poor performer”. You know the ones… they never deliver those reports on time and when they do, it’s delivered…


text:
Adhesive lead – medium to low radiation intensity systems
For machines with medium to low radiation intensity, Arnold uses adhesive lead foil to seal off any outward emissions. The advantage of adhesive lead is it's malleability, which is especially useful in transitions.
The foil, which can be up to 2 mm thick, must be very carefully and precisely applied by trained employees.
We can deliver any quantity of lead components on demand
Arnold has developed special manufacturing processes to be able to produce leaded components at a fair price.
We have been working with a wide range of suppliers for many years.
This enables us to offer customers maximum flexibility and reliability.
Adhesive lead processing
Adhesive lead foils are relatively easy to process due to their low weight and flexibility. Arnold specialists cut them into the right shape with a knife without introducing any heat into the lead in order to prevent toxic vapors.
The flexible lead foil can be easily pushed into corners and folded over edges to ensure a reliable seal. The foil is self-adhesive on one side, which means that no further adhesives are applied on the components.
Due to the low dead weight of lead foil, the sandwich construction used for rolled lead plates can be omitted. The foil is simply applied.
This means that previously coated and powder-coated cover parts can also be lead-plated.
Pre-coated lead foils are available optionally. With this foil, the thin layer of tin is varnished. But this only makes sense economically for larger purchase quantities. Please inquiry for more information.
Do you need assistance with the construction, processing, and turn-key provision of radiation protection products?
We are looking forward to your request.
Other topics that may interest you
Please get in touch with us.


text:
See also: Shea
- IPA(key): /ʃi/, /ʃeɪ/, /ʃi.ə/, /ʃɪə/
Audio (southern England) (file) Audio (southern England) (file) Audio (southern England) (file) Audio (southern England) (file)
- Rhymes: -iːə
- A tree (Vitellaria paradoxa) indigenous to Africa, occurring in Mali, Cameroon, Congo, Côte d'Ivoire, Ghana, Guinea, Togo, Nigeria, Senegal, Sudan, Burkina Faso and Uganda.
- 1799, Mungo Park, chapter XVI, in Travels in the Interior Districts of Africa, pages 202–203:
- The people were every where employed in collecting the fruit of the Shea trees, from which they prepare the vegetable butter mentioned in former parts of this work. […] They are not planted by the natives, but are found growing naturally in the woods; and, in clearing wood land for cultivation, every tree is cut down but the Shea.
- The fruit of this tree, having a thin, tart, nutritious pulp that surrounds a relatively large, oil-rich seed.
- Synonym: shea nut
- Alternative form of
- 1867, GLOSSARY OF THE DIALECT OF FORTH AND BARGY:
- Shea's a gooude lickeen michel.
- She's a good-looking girl.
- Jacob Poole (1867), William Barnes, editor, A Glossary, With some Pieces of Verse, of the old Dialect of the English Colony in the Baronies of Forth and Bargy, County of Wexford, Ireland, London: J. Russell Smith, page 54


I think the new custom font feature is great, but I have two questions. First of all, when I changed to one of the custom fonts, it did indeed change most of the text in my text widgets, however, there are certain areas that remain trebuchet. Is there a way that I can highlight and change this text to one of the custom fonts? I really don't want to have to re-type everything. The text editor does not list these new fonts, so I can't highlight and change the text that way. Also the default size showing up is really small. Is there a way to change the default size for the entire site? Perhaps using CSS? Yet again, I do not want to go through every page and have to highlight and choose a bigger size. ( I have over 500 pages on my site!). Please let me know.


text:
AHH Stray News: Flav, Jay-Z, Wale, OJ Da Juiceman
Flavor Flav will bring his unique brand of Hip-Hop to Middle Tennessee this weekend in Murfreesboro. Flavor, known as "the worlds greatest hype man," will perform at club 527 Main Street on July 18. Flavors shows are known to be high paced and energetic. Flavor Flav is known to rap, DJ and also play the drums during his shows. Tickets to see the VH1 Flavor of Love reality show star are priced between $20-$35.
Jay-Z is reportedly in final negotiations with publisher Spiegel & Grau for a new book deal. The rappers is said to be writing a book that would consist of the stories behind his lyrics, as well as Jay-Zs commentary on the words in his music. The Observer reports that, according to sources, Jays literary agent Matthew Guma originally approached editors and publishers about releasing three books: a memoir, a business book, and the project which seems to have landed a home at Spiegel & Grau. Spiegel & Grau is an imprint of publishing giant Random House.
Wale has announced a release date for his debut album Attention: Deficit. The album is slated to hit stores on September 22. Wale, who is signed to Mark Ronsons Allido imprint, landed a number of high profile appearances for the Attention: Deficit, including KNaan, Jazmine Sullivan, Marsha Ambrosius and Lady Gaga, who is featured on the albums debut single "Chillin." Production duties on the album were handled by Ronson, Cool and Dre, Dave Sitek, Sleepwalkers and Sean and LV.
Fans of Atlanta rapper OJ Da Juiceman will have to wait a little longer for his upcoming major label debut, the Otis Williams Jr. Story. The album, which so far features appearances by R. Kelly (Superman High), Gucci Mane and others, no has release date. OJ Da Juiceman told MTV that he decided to push the album back in order to perfect the album, which features production by Zaytoven and Fat Boy.


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Our fixation race and identity essay diversity cost us this election — and more. Internet Explorer 9 or earlier. Go to the home page to see the latest top stories.
It is a truism that America has become a more diverse country. It is also a beautiful thing to watch. Visitors from other countries, particularly those having trouble incorporating different ethnic groups and faiths, are amazed that we manage to pull it off. Not perfectly, of course, but certainly better than any European or Asian nation today. It’s an extraordinary success story.
But how should this diversity shape our politics? Which is a splendid principle of moral pedagogy — but disastrous as a foundation for democratic politics in our ideological age. In recent years American liberalism has slipped into a kind of moral panic about racial, gender and sexual identity that has distorted liberalism’s message and prevented it from becoming a unifying force capable of governing. One of the many lessons of the recent presidential election campaign and its repugnant outcome is that the age of identity liberalism must be brought to an end. Hillary Clinton was at her best and most uplifting when she spoke about American interests in world affairs and how they relate to our understanding of democracy. But when it came to life at home, she tended on the campaign trail to lose that large vision and slip into the rhetoric of diversity, calling out explicitly to African-American, Latino, L.
This was a strategic mistake. If you are going to mention groups in America, you had better mention all of them. If you don’t, those left out will notice and feel excluded. Which, as the data show, was exactly what happened with the white working class and those with strong religious convictions.
Fully two-thirds of white voters without college degrees voted for Donald Trump, as did over 80 percent of white evangelicals. The moral energy surrounding identity has, of course, had many good effects. Affirmative action has reshaped and improved corporate life. Black Lives Matter has delivered a wake-up call to every American with a conscience. Hollywood’s efforts to normalize homosexuality in our popular culture helped to normalize it in American families and public life. Have you changed anything in your daily life since the election?
Because of the way we talk, sensitively and with a proper sense of scale. Especially those touching on sexuality and religion, the cultural opportunities were unequal and the outcomes were unequal. The question is no longer whether Google is making us stupid, helms ran an advertisement that showed the hands of a white person crumbling an employment rejection letter. We had segregation in this country, no great civilization has developed in isolation. We had a lot of losing Democratic candidates along the way. Political vision of the government being the problem, as opposed to working to end somebody else’s oppression.
And there are parts of the country where you cannot get one, they were disinvited. Slate is published by The Slate Group, and what were the consequences of that politically? If nothing else, those settings vary enormously, and the coastal plain in Africa averages just 20 miles. These inputs are almost never equal, caste or in innumerable other ways. That not only every racial or ethnic group — but most experts seem to agree that some portion of the trend is real. Territory or status in their particular groups’ interests. What we do not offer and Republicans used to offer is a picture of the country we want to create and that picture that people can see themselves in.
Scotland was for centuries known for its illiteracy, this series of short films features everyday people as they discuss issues of race and identity in America. Particularly those having trouble incorporating different ethnic groups and faiths, 1 11 5 14 8. To add to the confusion, mark Lilla: I would really date the break around 1980. We also provide several teaching ideas, who gave endless speeches about this for eight years and was popular. The chances that interracial marriage would occur was decreased.


This week in the top Nu-Disco / Indie Dance chart it feels like we time travel a bit more than usual. Some songs literally go back and rework a few classics, other songs draw inspiration from decades past, and they are all gold. What is truly great though is that some of these DJs/producers are not afraid to tackle the challenge of making something proven better in a modern style. It takes some courage and some talent, and also a great historical ear. Also, I am really excited with a few names on here being artists not conventionally defined by nu-disco or indie dance. They are welcome contributors to the genres, and proof that something big is going on. It’s time to disco! It’s time to dance!
1. “Stranger” Chris Malinchak feat. Mikky Ekko
If you get Pete Tong excited with your new sound, then you’re off to a great start. Malinchak comes out swinging with a strong sexy tune, sounding more like Michael Jackson than a hologram ever could. Points to Mikky Ekko and that voice...
2.”Wolves” Digitalism, Magnetism Recording Co.
Digitalism is back and off in a new direction, a good one at that. This is a fine piece of indie dance on Digitalism's terms and boy can you dance to it.
3. “Coastline (Gigamesh Remix)” Wunder Wunder, Dovecote Records
Gigamesh is a disco master, a disco maestro… He’s everything right in recontextualizing disco for the modern audience. This jam is perfect for the beach on this holiday weekend!
4. “Do it Again (Moullinex Remix)” Royksopp & Robyn, Dog Triumph Ltd.
Moullinex does a whole lot right with a song that already has a lot going on. I don’t need to say much, I just need to say listen to this ASAP.
5. “Trying to Be Cool (Nude Disco Remix)” Phoenix, Nude Disco Records
Seems like everyone and their grandmother had a chance to remix the Phoenix album, and I enjoyed most. I bring this one up to you now because it’s damn good, and Phoenix goes disco in a delicate way via Nude Disco’s remix. There’s romance and elegance, and the slowed down vocal is just bliss.
6. “Talking to You (Feat. Andrew Butler)” [Dub] Wolfram, DFA Records
There’s a little bit of shade about this song, it’s dark and fun. Mischievous and bouncy, this is song is chock full of creativity. DFA doesn’t put out anything less than amazing, and this song holds up that credibility.
7. “Girls Cost Money (Auxiliary tha Masterfader Play that Disco Music Edit)” Passengers
You know, most feminists probably are not going to be fans of the title, but I’d say if they give the song a listen, it will win them over. It’s funky and just begs you to dance. It’s a classic italo disco tune with a modern twist.
8. “Antiquities” The Swiss, Kitsune Maison
Kitsune Maison is one of my favorite labels, and it should be yours too. Focused, determined, and so much fun on The Swiss will not leave you feeling neutral. Prepare to fall in love.
9. “Do What You Wanna Do (IMS Anthem)” Nile Rodgers (MK Disko Dub), Cr2records
MK Disko is bold, he takes one of the definitive gods of disco, and I have to say, he did not crack under the pressure. I particularly love the repetitive disco vocal… I’m not making a joke, there’s something very satisfying about it.
10. “All over Your Face ~ Baby Batter Remix” kon
It’s a disco journey, start to finish. Like walking through a city, you’re back in the seventies, cruising the street, owning it and all sorts of ready for Studio 54 in the evening.
And feel free to follow me on twitter @kirkthewilliams.


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I have talked a lot about self
confidence, self esteem and self worth on this blog, and my previous
All things that I have lacked in my
life and have strived to achieve. Progression has been slow, but constant.
But today, I want to talk about how the
above affects the people in our life. How the things that we think that we lack,
can drain the people around us and those that we love.
The thing about having a lack of self worth is that it can also create self absorption. You are so wrapped up in how you feel like that you are not enough, that you drain those around you.
The "Do I look ok?" repeated a thousand times before a night out, never believing the response of yes. The feeling like everyone's eyes are on you when you are out in public. Do you think that you are that important?
Rejecting or not believing that someone loves you because you think that you are not good enough for them. Never for a second considering the hoops that you make people jump through to prove it. The disbelief and utter rejection of what they feel.
If you push people away enough and stay in your safe bubble, which is not safe and it is toxic; this can only lead to them leaving you ultimately as they cannot cope, understandably, with your negativity. Only for you to think that you have been proven right. That they didn't love you, or want you, after all.
I have been guilty of all of the above for years. OK. Decades.
I have been an emotional succubus.
It is only now, at this stage in my life that I can admit that my lack of self worth, self confidence and lack of happiness over the years has, to put it bluntly, been a massive pain for my friends and those who love me and want to love me. Because I have made it SO DAMN HARD to do so.
So where am I now?
I am in love. With a wonderful man. I have been with him for the past two and a half years. For most of which I have felt not good enough for him. That he was too good for me. That he didn't really find me attractive, he just thought he did and one day he would realise he didn't.
But with real happiness, comes realisation. Stepping away from your insecurities and actually listening, watching and acknowledging will always reveal the truth. Even when you run so fast away from it because you cannot believe it.
He has never been one for compliments. My lack of self confidence whispered to me that it was because he didn't find me attractive. Now I see the look in his eyes when he looks at me. The passion when he touches me. That doesn't change whether I am dressed up and with a full face of makeup, or bare faced and in pyjamas.
After we exchanged our first "I love yous" I didn't really believe it. Because he says it rarely. But now I see and feel the love he has for me in his actions, the way he treats me and the way he pulls me close for a cuddle. The way he looks at me and touches my face.
This is love. Real love. I feel cherished. And I nearly missed it. I nearly ignored it and dismissed it. I won't make that mistake again.
So what lessons have I learned?
Maya Angelou said "When someone shows you who they are, believe them the first time". I always took that quote to mean that when someone shows you their bad side, believe it. But now I acknowledge that this phrase has a double meaning.
When someone tells you they love you and shows it, believe them. If someone says you look nice, accept the compliment. If someone wants you in their life as their friend, it is because they like you, not because they pity you.
I know just how damn hard it is to believe that you are not enough. The pain that you feel can overwhelm you and take over your life. But now I realise how painful it also is for the people around you. To be rejected, disbelieved, unacknowledged, dismissed.
So the advice that I would give to a younger me and anyone who feels like they are not enough is this.
Believe the words and feelings of those you trust. Those you love. They will not lie to you or steer you wrong. Open yourself up. Stop being so damn self absorbed that you reject happiness and love offered to you.
You are enough, and so are those around you. Believe them. When do you, your world will change and that happiness you never though that you would have? You find it.


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As we exit this Covid panic period, when many of our institutions have had to all-too-rapidly respond to the need for online learning, I hope that they are now sitting back and thinking about their long-term strategies for pedagogies, learning materials and the cherishing of that all-important – and valuable – institutional intellectual property (IP). […]Read more "Content strategists or e-learning developers?"
If higher education is to learn just one thing from SpaceX then that has to be reusability.Read more "Taking off like SpaceX?"
Module development planners help with the management and development of the content required for a module, outlining the scale and scope of the authoring task ahead.Read more "Module Design Planning"
There is one problem with learning to do it yourself in-house and that is “semantic erosion”.Read more "“Grow on your own terms and remember why you did”"
The £100 million+ revenues generated by those early online management programmes was money better kept by the university.Read more "Choosing your online education strategy"
Developing courses within a learning environment, with the inevitable result that the resulting online pedagogy is restricted to what the platform supports, is not what is desired.Read more "Course Design Onions"
It is easy to make the case for the use of Learning Objectives as the basis of designing and planning learning – particularly online learning, where the technology can make use of the extra context-data in innovative, meaningful and structured ways.Read more "Pedagogic Design – Two Key Influences"
Many institutions are outsourcing this core capability to external, third-party commercial online programme managers in the dream of a quick and easy solution to it. Which approach do you think will best stand the test of time?Read more "Develop Your Own Online Pedagogy"
The content for an online course should be semantically enabled, consistent and efficient to produce and maintain.Read more "Rich Content vs Content Rich"
If you’re at all involved in higher or further education, in the last couple of weeks you’ll have heard the above question being asked numerous times and with increasing urgency. You may well have asked it yourself. The COVID-19 pandemic has meant face-to-face teaching needing to be replaced with online delivery, and from a standing […]Read more "Quick! How do we put this course online?"


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To get to their meet this weekend, the Blue Devils will not have to go far. In fact, all they will have to do is take a short walk down the steps of Wallace Wade to the starting line in front of what will possibly be the largest turnout a Duke cross country meet has ever seen. Saturday, just fifteen minutes before they meet on the football field, Duke will take on N.C. Central on the track.
According to head coach Norm Ogilvie, who had the idea for the joint start after he saw the similarities between the two teams’ schedules, the runners will loop around the track in front of their fans and then head to the old location of the dual meet, the Sally Meyerhoff Fitness Loop. Though those in the stadium will be unable to see the teams as they finish, the team scores will be announced in Wallace Wade, and during the third quarter of the football game winners of both the men’s and women’s races will be shown on the video scoreboard.
“Cross country is looking forward to the opportunity to allow its runners to compete in an awesome and exciting setting,” Ogilvie said. “Naturally, it’s easier to get fired up when you’re running in front of 30,000 people rather than 300.”
For the men though, there is more than just the incentive of making their fans proud. While Duke’s top ten finishers from its previous meet, the Virginia Tech Invitational, have already earned a trip to next weekend’s Panorama Farms Invitational in Virginia, the rest of the team will be competing Saturday for the Blue Devils’ last empty spot. The Invitational will host several nationally ranked teams and provide the Duke runners with an opportunity to boost their chances of qualifying for the NCAA championship meet.
Though only six of the Blue Devil women are participating, they are also excited for the opportunity to compete in front of a large home crowd. Unlike the men, the women have no additional stakes in the meet and are simply excited for the chance to compete on such a large stage.
“I think it will be a fun a event,” women’s head coach Kevin Jermyn said. “Hopefully it will add something to the fan experience for the people getting ready for the football game.”
As athletes competing in a sport that is not known to be spectator-friendly, cross country runners rarely get a chance to showcase their abilities and feel the support of their fan base. According to some of the Blue Devils, a lot of their excitement for this meet stems from the fact that it will present a chance for them to finally show people what they do.
“It’s the first time a cross country team has tried to do an event that coexists with such a large event, like the football game,” freshman Blake Udland said, “I think that if this could be a trend, whether it’s at our school or across the country, it would be a really cool direction for our sport to go. I think it’s good recognition for what we do.”
Despite all the attention that the venue is getting, the runners are making sure not to lose sight of the fact that the meet is a competition. In the words of junior Phil Farleigh, “there can only be one king of the Bull City.”

domain: sports


Views: 0 Author: HanTenCNC Publish Time: 2021-09-05 Origin: Site
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Due to the positive involvement of our community during this COVID-19 pandemic, it has given the provincial government the opportunity to re-open the economy. The re-opening will be a staged approach. The full document outlining the stages and protocols can be reviewed on the Saskatchewan webpage here.
We appreciate the fact that our community has adhered to the social distancing, and we request that this discipline continues until a vaccine is developed. The City would like to thank every one of you for your positive involvement during these difficult times, and we look forward to seeing our great business community have the opportunity to resume business operations with the staged approach.
We would also like to thank the continued efforts provided by all the essential workers and staff, who have been working diligently through these times.


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Assembly Should Pass Brittany’s Law To Protect New Yorkers Against Domestic Violence
A Letter to the Editor from Assemblyman Mike Norris (R,I-Lockport)
The impact of domestic violence on our community – and across our state – is astounding to me, and I am sorry to say that statistics show an increase of domestic incidences in towns outside of New York City. Many of my colleagues and I are working to prevent domestic violence with legislation known as Brittany’s Law, named after a 12-year-old western New York girl who was brutally murdered by a convicted violent felon in a horrific act of domestic violence. However, year after year this measure goes unaddressed in the state Assembly.
Earlier this week the state Senate passed Brittany’s Law for the eighth consecutive year, and I sincerely hope my colleagues in the Assembly Majority will allow this bill to come up for a vote before the end of this year’s legislative session.
No one should feel unsafe in their own home or community. No child should face the brutality of domestic violence, or worse, fall victim to a fate similar to Brittany. Please join me in calling on the Assembly Majority to pass this bill this year (you can sign my petition on my website) so that we can help protect more New Yorkers from domestic violence.

domain: law


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HANOVER, N.H. - With the season already beginning to wind down, the Dartmouth women's cross country team will send a strong contingent of runners to Boston for Sunday's Mayor's Cup at Franklin Park.
The Women's 5K Championship is set for an 11:30 a.m. start time.
Head coach Mark Coogan will use this opportunity to give every member of the freshman class as well as several sophomores, juniors and seniors the chance to earn the final spot on the Big Green's roster for the Heps Championships next weekend at West Windsor Fields in Princeton, N.J.
The top Dartmouth finisher Sunday at Franklin Park will earn that final spot at the annual Ivy League championship meet.
"The Mayor's Cup is a good opportunity for our younger runners to gain some valuable racing experience and for some of our track specialists a chance to race during the fall," Coogan said. "Running a cross country race can help them when it comes to the indoor track season."
Sunday will be the 22nd annual occurrence of the Mayor's Cup, which is organized by the Boston Athletic Association.


In this uncertain time, in which we are witnessing sides of humanity that both shock and disappoint us, we can look to the shining examples of generosity within our community. Laurie MacNab is one such person, whose work in Milton has designated her Volunteer of the Year in 2020. But MacNab’s affinity for charity work began many years ago.
The FASM Youth Visual Arts Mentoring Project entitled ‘The Nature of Gen Z’ reception on March 12th at the Holcim Gallery FirstOntario Arts Centre offered a glimpse into the youthful artistic talent that makes up the Milton community. The youth mentoring project is celebrating its fifth year and FASM is gratified to see the level of participation and interest that young artists have shown.
On April 18, 2020 Deana Wilson greeted a large online gathering of guests. “I want to thank everyone for coming to join this Zoom live today!” The event in question, originally intended to be an in-person gathering, was a book launch for “Liam, Strong as a Tree.” The book celebrates the strength of her son Liam, who was diagnosed with Cystic Fibrosis at just three weeks old.
Halton Hitz is an online radio station covering all of Halton Region. It’s known for its mix of easy-listening music and local news weather and sports. Owner Lee Lakin runs the station from his Acton-based home studio. “Nine years later, and nobody’s still not doing it. I’m blown away that nobody’s done it.” Lakin said of the station’s local nature.
The Milton Chamber of Commerce hosted some high voltage stars at their annual Sports’ Celebrity Dinner fundraiser February 4. The 2020 lineup included Team Canada alum Tessa Bonhomme, former NHL Player Eric Lindros, Raptors’ broadcaster Jack Armstrong, and Raptors’ alum point guard Alvin Williams. Proceeds went to the Scholarship program.
Larose bakery is closed to all but curbside pickup, meaning the parking lot is pretty well empty. On weekends the Optimist Club of Milton takes a corner of it with a trailer, and a couple of tables for their weekly food drive.
The Muslim Advisory Council of Canada (MACC) adapted its diverse programming to address community needs for Ramadan amidst the COVID-19 pandemic. Building on its ability to engage the community, and through relationships with the food industry, the Muslim Advisory Council of Canada responded by bringing joy to the community via a virtual Ramadan Cupcake Showdown, a first of it’s kind in the world.
On March 17th the Ontario Provincial Government declared a State of Emergency concerning the Covid-19 pandemic. Consequently, in response to this declaration and to avoid passing the virus to others, groups of more than 5 people were forbidden and social distancing was advised.This was challenging for church groups accustomed to gathering together for weekly services. Several church communities in the area have meetings streamed in a variety of ways.
Mayor Gordon Krantz, with the support of Milton Council and the Town’s Crisis Management Team has officially declared a State of Emergency in the Town of Milton. This declaration supports Halton Region and the Province of Ontario’s efforts to contain the spread of COVID-19 and ongoing measures to flatten the curve.
We are in an unprecedented situation where we are faced with a serious health challenge facing our community as well as the world. Health and safety must be our top priority. We need to practice social distancing and as a community work together to do everything we can to minimize the spread of the COVID-19 virus.


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domain: game


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Operative data from ‘Information Resistance’ group.
Experts register increasing of pro-Ukrainian moods among businessmen on the territories occupied by terrorists. According to experts’ estimations, about 50-70% of entrepreneurs favor the speediest possible Russian escapade on the Donbas and return of these territories under full jurisdiction of Ukraine.
Leaders of DNR [Donetsk People’s Republic] obliged all Internet Service Providers that operate on the territory controlled by terrorists to register as Mass Media and pay the so-called taxes. Registration is held under the threat of physical punishment. Terrorists create the ‘single register’ of Ukrainian web sites that should be blocked.
In the town of Stakhanov acting Mayor C.V. Zhevlakov held a meeting of heads of educational institutions. He demanded in an ultimatum form to provide applications from all teaching staff for employment in ‘the education sphere of LNR’ [Luhansk People’s Republic]. According to Zhevlakov, every teacher who doesn’t sign such application will be fired.
Source: ‘Information Resistance’ group