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Four men have been arrested in Cameroon for allegedly being gay.
According to gay rights activist Stephane Koche, the men were arrested in their homes on December 28 and are being held in custody at the central police station of Kumba, a town in the south west of the African country.
Koche, who works for the Association of Defence of Homosexuals (ADEFHO) in Cameroon, says police officers arrested each of the men because they behaved like women.
He told Gay Star News: ‘There are many people arrested for being gay in Cameroon. Our organization provides legal and medical assistance to people who have been imprisoned.
‘These people are often abandoned by family, friends or neighbors and they need help with everything.
‘They are in unhealthy conditions and need food and money.’
At least 10 men have been arrested and imprisoned for homosexuality in Cameroon so far this year, not only for what they allegedly did, but for who they are, or even appeared to be.
‘We exhort you to never give up in to the discouragement and to never weaken in your mobilization for us and for the LGBT cause,’ the message reads.
‘Your support represents for LGBT in Cameroon in general and specially for us who are in prison…the hope.
'The hope to be one day, released from the prison in which we’ve been thrown, but also the hope that one day, LGBT people can walk quite freely in Cameroon, without any humiliation.’
The prisoners have been named as Jean Claude Roger Mbede, Singha Jonas, Ndome Ndome Frankie, Ombwa Joseph Magloire, Tiomela Lontsie Emma, Ntamack Nicolas and Ntsama Séraphin.
According to human rights campaigners Amnesty International, homophobia is endemic in Cameroonian society.
Arrests, prosecutions and trials of gay men occur on a regular basis in the country.

domain: sociology


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BAGMATI: Construction of a powder milk production plant and its building has been started in Hetauda, the capital of Bagmati province.
The structure is being constructed at Nyureni of Hetauda Sub-metropolitan City-10, with the grant of Rs 412 million 271 thousand provided by the province government. It is believed that with the operation of the plant, it would benefit the dairy farmers of the Bagmati province and other provinces as well. With the operation of the plant, 60 thousand litres milk produced by some 22 thousand farmers from Bara, Parsa and Rautahat districts of Province no 2 as well as Chitwan and Makawanpur districts of Bagmati province would be procured to produce five metric tonnes powder milk daily, the Province Dairy Board stated.
Milk can also be imported from Mahottari, Sarlahi, Rautahat, Parsa, Chitwan, Nawalparasi, Bara and other districts for the plant. The target is to complete the construction of the plant and its building within about one and half years.
Comment here !
BUTWAL:- Fourteen people have died of Covid-19 in Dang and Banke districts of Lumbini province. Among the victims are six
KATHMANDU:- Nepal has expressed its concern over the escalating tensions between Israel and Palestine, urging both sides to exercise utmost
KATHMANDU:- The offices apart from the most essential ones will remain closed in the Kathmandu Valley from tomorrow (Thursday). According
WASHINGTON, (AFP):- The major US pipeline network forced offline by a cyber attack began to reopen Wednesday, its operator said,

domain: agronomy


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I've been seeing some English and European football for the first time this year. Fox and CNN have been carrying some Premiership games a week delayed and also they carried one match per week of the UEFA Champions League. I've been enjoying them a lot. I am not a fan of basketball, so the English and EU football seasons has been filling the sports void between the end of the US NFL and MLB seasons.
So, I see from various on-line sources that the FA Cup is being played soon. What is it? I know the FA is the Football Association, but beyond that, what decides the teams to play? Man Utd vs Arsenal sounds like the top two from last year's Premiership but my memory is a bit hazy on that. But it sounds a bit strange to someone familiar with US customs: why not let this year's top teams play against each other?
I've looked for a decent FAQ that could help a newbie understand what all the darn championships/cups are in UK and Europe, but haven't found one, so I'd appreciate a link to one if you have one.
I realize all sportscasts presume a knowledge of the game and the teams. I more or less know the rules of the game (they aren't all that hard, are they?) but I don't know much about the teams. For instance, all the teams seem to have one or more nicknames. How can I get up to speed on the lingo?
What are some of your favorite links for keeping up with the happenings of the game? Keep in mind I haven't developed much if any attachment to any particular team, so I'd like to find one that covers the sport broadly.

domain: sports


Table of Contents
- What year did Porsche fix the IMS bearing?
- Which Porsche models have IMS problem?
- Does 2006 Porsche 911 have IMS issues?
- What year is Porsche IMS?
- Does the Porsche 997 have IMS issues?
- What year is the most reliable Porsche 911?
- What is IMS failure Porsche?
- Where is the IMS bearing?
- Is a 996 A Good Investment?
- How much does it cost to replace Porsche IMS bearing?
- Are Porsche 997 reliable?
- Is the Porsche 997 collectible?
- Will Porsche 997 be a classic?
- Is a Porsche 997 A Good Investment?
- What year is the best Porsche?
- Which Porsche 911 should you avoid?
- Which Porsche 911 holds its value best?
- What is IMS in a Porsche?
- How can IMS bearing failure be prevented?
The IMS Solution is a permanent fix with no service interval. From 1997 to 1999, Porsche use a dual row intermediate shaft bearing which has proven to be as robust as the larger single row used from 2006 through 2008 model years.
What year did Porsche fix the IMS bearing?
Not to nitpick, but the difference is that in 2009 model year, Porsche eliminated the IMS bearing completely. However, the 2006-20008 (with the exception of some very early 2006 model years that still had the left over M96 motor) did not eliminate the IMS bearing, but basically eliminated the failure of the bearing.
Which Porsche models have IMS problem?
Which Porsche models can IMS bearing failure occur on? Boxsters, Caymans and 911s from MY1997 to MY2008 are all at risk of IMS bearing failure, with the exception of Turbo, GT2 and GT3 models. However, the type of bearings used changed over the period and some were more prone to failure than others.
Does 2006 Porsche 911 have IMS issues?
The incidence of IMS failures in 2006-2008 Porsche Boxster, Cayman, and 911 models with the M96 or M97 engine is very low. Owners of 2006 through 2008 Boxster, Cayman, and 911 (997) models don’t need to rush out to have their engine disassembled to replace the IMS bearing.
What year is Porsche IMS?
But for all that, there is a dark spot in the Porsche 911’s history. It’s the 996 (1999-2004) 911, and the problem is the Porsche IMS bearing.
Does the Porsche 997 have IMS issues?
The IMS bearing issue is a carryover issue from the 996 model. The earlier non-Carrera S 997 models had the same basic engine as the 996, hence, the same issues. Most late 2005 and early 2006 997 models are included and, as mentioned earlier, a very small percentage of those cars were affected.
What year is the most reliable Porsche 911?
Anything from 1984 onwards is your best buy for reliability. The pick of those is the 87-89 models because they had a better gearbox.
What is IMS failure Porsche?
If you own a Porsche, you have probably heard the term “IMS Bearing Failure.” IMS stands for Intermediate Shaft (Bearing) which supports the intermediate shaft on the flywheel side of the motor.
Where is the IMS bearing?
What is an IMS bearing? IMS stands for ‘Intermediate Shaft’, and the IMS bearing supports the intermediate shaft, on the flywheel end of the motor (See here). The purpose of the intermediate shaft is to drive the camshafts indirectly off the crankshaft.
Is a 996 A Good Investment?
The 996 offers the best value for money, provides good performance, gives the younger generation a chance to enter the 911 market, and it’s a sports car that can be used everyday. Calling the 996 the best 911 won’t go down well with many Porsche purists, but for some car enthusiasts this is exactly the way they see it.
How much does it cost to replace Porsche IMS bearing?
THE SOLUTION The cost of a IMS Retrofit replacement bearing and labour for installation is usually more than $4,000 but can be done in conjunction with the clutch. This is a small investment compared to the cost of rebuilding or replacing the entire engine.
Are Porsche 997 reliable?
The majority of the car is generally reliable and has a near timeless look. With the launch of a new 992 platform, prices for the 997 have been driven even lower. This is a super value for money, everyday super car that has excellent reliability.
Is the Porsche 997 collectible?
The 997 generation cars are still relatively modern and thus include the necessary creature comforts to be acceptable as daily drivers. But they are not too old to be considered collectible yet, so prices have yet to skyrocket like the 993 generation.
Will Porsche 997 be a classic?
The Porsche 997 has been the first of the modern 911s, which took its design inspiration from the classic 911 again. With the oval shaped headlights, it is already considered as a future classic. The 997 is a genuine 911. The first generation of the Porsche 997 is already considered as a future classic.
Is a Porsche 997 A Good Investment?
The 997 is a great all-rounder that represents excellent value for money. Moreover, it can be driven any day of the year, and that will get you into the prestigious 911 club for an affordable price.
What year is the best Porsche?
So here it is, our list of the best 911’s of all time. 1963 Porsche 901. Year: 1963 Generation: 901 Units built: 82. 1967 911 S Coupe. 1973 911 Carrera RS 2.7. 1974 Porsche 911 Carrera RS 3.0. 1974 Porsche 911 3.0 RSR. 1989 Porsche 911 3.2 Carrera CS. 1989 Porsche 930 LE. 1989 Porsche 911 Speedster.
Which Porsche 911 should you avoid?
Quick answer: Avoid Porsche 911 year models 1983 and 2009 Of over 50 years of year models, there are really only two Porsche 911 models you should truly avoid: the 1983 year model and the 2009 model. The 1983 Porsche 911 reportedly has issues with broken head bolts that may pop up under 40,000 miles.
Which Porsche 911 holds its value best?
The 2020 Porsche 911 is our top pick for the best model year value for the 911. With the 2020, you would only pay, on average, 79% of the price as new, with 92% of the vehicle’s useful life remaining. The 2018 and 2019 model years are also attractive years for the 911, and provide a relatively good value.
What is IMS in a Porsche?
The Porsche IMS (stands for intermediate shaft) is a geared shaft that runs through the front and rear of the engine. It indirectly drives the camshafts on either side of the engine by way of the mechanical rotation of the engine’s crankshaft.
How can IMS bearing failure be prevented?
Install a retrofit kit (applicable to 1997-2005 M96 engines) or the IMS Solution (a permanent solution applicable to 2000-2005 single row IMS bearings): this is the best way to avoid IMS bearing failures.


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Urologists rank third in earnings, tied with gastroenterologists, in a survey of physician compensation conducted by Medscape.
A new study has found that for men 65 years of age and older, robot-assisted radical prostatectomy and open prostatectomy have similar rates of complications, providing further evidence that outcomes between the two procedures are not significantly different.
Is inflammation a potential target for the treatment of BPH? New research being presented at the 2014 AUA annual meeting may help answer this question.
Research in stone disease and minimally invasive surgery will also make its mark at the Society for Pediatric Urology annual meeting, which runs concurrently with the first 3 days of the AUA meeting.
New research about staged buccal mucosa graft urethroplasty and a study examining urethrotomy with mitomycin C for recurrent bladder neck contractures are among the key research in trauma/reconstruction being presented at the 2014 AUA annual meeting.

domain: literature


text:
By Alasdair Sandford
BBC News, Clichy-sous-Bois, France
The evidence of the previous night's trouble is clear to see on the Bosquets estate.
Burnt-out vehicles and debris remain on Clichy's streets
Among the cars parked outside one block of flats are two burnt-out vehicles and small piles of debris. Rocks and stones are strewn across the street.
There is no sign of any security presence and people are shopping and chatting as on any normal day.
It does not take long to get a sense of the hostility some feel towards the police.
A driver pulls up in front of the market, his little boy strapped in the back of his car.
He admits belonging to a group that is sometimes a bit "chaud" - meaning troublesome - a hint at the unrest of the past few days.
He describes the nightly presence of the CRS, the French riot police, as provocation.
"If they didn't come here, into our area, nothing would happen," he says. "If they come here it's to provoke us, so we provoke back."
The French Interior Minister, Nicolas Sarkozy, has promised to send in special police units to "occupy" difficult estates, describing urban gangs as "rabble".
"We're not rabble," says the man, "we're human beings, but we're neglected."
Clichy residents complain that police stop young people for no reason
Across the road from the market, 57-year-old Boubaker acknowledges that delinquency is a problem.
He often chides small groups of youths hanging around outside his flat. He agrees the police have a job to do, but says that often they are too aggressive and pick on the wrong targets.
His 19-year-old son is regularly stopped when out with friends - especially if they are black - by police who demand to see their ID.
"Each time he goes out he has to prove who he is," says Boubaker, "even right outside his own front door."
Most families on the estate are originally from African countries. Unemployment is high and the area is poorly served by public transport.
Boubaker is Tunisian and has lived in France for 30 years. His eldest son is 29 but still lives at home because he cannot find affordable housing.
All four children are in work but their friends - again especially those who are black - have to make "hundreds" of job applications before getting an interview.
"It's the French mentality. They still haven't understood that even children with foreign origins have their place in society," says Boubaker. "They still think we're cleaners, and that's not good."
Nicolas Sarkozy has talked of the need to provide young people with job opportunities.
The interior minister is also an advocate of positive discrimination for ethnic minorities, and of voting rights for foreigners.
But for people in Clichy, what sticks out is the evocative language he has used to back his "zero tolerance" crime policy.
He once said an estate needed a "Kaercher clean", referring to the name of an industrial cleaning manufacturer.
Another man, at the market, says: "Immigrants came here after World War II to help rebuild France but he says their children need a 'Kaercher clean'.
People remember that here."
And once again the conversation turns to the police.
"It's the way they stop and search people, kneeing them between the legs as they put them up against the wall. They get students mixed up with the worst offenders, yet these young people have done nothing wrong."


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The varieties used for wine production at Quinta da Penina are the traditional Portuguese and some French recognized quality wine grapes.
It´s a variety of French origin, widely cultivated in Portugal for many years.It has a high color intensity (dye variety) feature that is exploited to benefit less colored wines.
Produces wines with dark red color; when young they have a little vegetal aroma of spices and menthol. In time, the aroma turns to red fruit scents, reaching the jam.
Iberian red grape variety, from Spanish origin (Tempranillo), planted throughout Portugal with the names Aragonez/Tinta Roriz.
This grape has low acidity and high alcohol content. It produces wines with good color intensity, aromatically intense and complex.
They develop scents of plums and berries that turn more complex with the evolution; in the mouth they are smooth, well-structured and complex.
French red grape variety native of Bordeaux region. It is probably the most widely grown variety in the world.
It produces wines with a very interesting tannic structure. They are usually able for ageing in oak barrels.
The vegetal aroma of this grape gives way to more pleasant and complex aromas, when the grapes are well matured.
It is a red grape variety only existing with a productive quantity in the Algarve region, which makes it unique.
It has an outward appearance, with large and tricolor clusters (white, red and pink grapes).
Negra Mole produces pink to ruby ??colored wines, has a light flavor profile and is very aromatic and fruity.
Lightly pressed, it produces white musts, such as "Blanc de Noir".
Super fresh, mineral and saline wines, excellent for the best sparkling bases or for gastronomic whites.
Red grape variety originally from southwestern France (Medoc) considered improving quality of Bordeaux wines. It has no expression in Portugal. In the Algarve, Quinta da Penina pioneered their plantation and single variety winemaking.
When it is fully ripe, produces powerful wines, rich, full bodied and tannic. Presents aromas of black fruit (blackberry), spice, pencil shavings, tar and tastes like leather and tobacco.
These are wines of great quality, to be kept in cellar; in a blend, they can add body, color and liveliness to wines less exuberant.
French red grape variety native of Côtes du Rhône.
Their wines have good alcohol content, capable of ageing, with very good quality. Usually have an intense color, very aromatic, fine and complex (violet, olive, leather ...) with marked tannins and relatively weak acidity.
It cans also origin very fruity and interesting rosé wines.
Indigenous Portuguese red grape variety originally from northern Portugal, Douro and Beira. Considered the most valuable wine variety of Portugal has a high component of color, aroma and complexity.
The musts has medium/high acidity and high alcohol content; produce wines of great quality, soft, round and warm, reminding dark red berries, very ripe, with floral scents, dominated by violet and sweet scents remembering rock rose.
Produces wines with great ability to ageing.
Indigenous Portuguese red grape variety, spread throughout the country. It has a long tradition in the Algarve where it was called Crato Preto.
It originates musts with high natural acidity and medium alcohol content.
Produces wines with intense garnet color and black plum raisins aromas, herbaceous (associated with spices) and some pepper. In time, develops scents of jam, with complexity and finesse. In the mouth they are smooth, with some acidity.
Portuguese autochthonous white grape variety grows all over the country. It presents musts with high acidity and medium alcoholic level. It produces wines with citric color with high capacity for ageing.
The wines have aromas of some citrus fruit, sometimes mineral. Over the years they develop scents of honey.
In the mouth, they are acidulous with notes of fruit and some complexity.
Côdega de Larinho
Côdega de Larinho comes from the extreme northeast of Portugal, where the originated wines have a very marked character by the fruit.
This grape guarantees high yields, with dense clusters.
Medium maturing grape, originating wines of good complexity, fruity (tropical fruits) and flowers, not always of sufficient freshness due to their low acidity, but with an excellent aromatic profile and great persistence.
Portuguese white grape widespread throughout the country; also known as Síria or Roupeiro.
To show all their qualities it requires warm soil and a warm temperate climate, moderate, no rain in August / September.
It produces wines with a medium alcoholic and acid content, with citrus tones, intense aroma, with little notes of tropical fruits and ripe citrus.
In the Algarve can also produce fortified wines of great quality.
Portuguese white grape variety, with medium clusters and small yellowish green berries.
It is an early ripening grape variety, showing generally medium vigor and productivity; prefers dry soils and a moderate climate, showing good adaptation to the mechanical harvest.
Its high natural acidity makes it interesting for the preparation of batches with less acidic varieties.
It produces wines of high quality and with a reasonable aging capacity, with aromas of medium intensity, like orange flowers with more vegetal notes, presenting with liveliness, freshness and some persistence in the mouth.
A very Old Portuguese white grape variety, originated from North Portugal.
Presents high natural acidity (6-9 g / l ac. tart.) and very good alcohol content (14% vol.). At Algarve reveals a good mineral acidity, citrus aroma of green fruit and fine mineral notes.
Improver variety, originates excellent wines with good ageing ability.
It is a Portuguese autochthonous white grape variety from Douro region.
Presents an average natural acidity (4-6 g / l ac. Tart.) and very good alcohol content (13-14%vol.).
It has a good potential for single variety wines or in blends, with Sercial and Crato Branco (Síria).
It produces wines of great quality, with good ageing ability, good aromatic intensity, resembling chamomile, plum, giving a fruity bouquet with some complexity. In the mouth it is engaging, with a medium acidity, good body and pleasant aroma.
French white grape variety originally from the Rhône region
Produces wines with light clear golden color, with scents of flowers (acacia, violet and honey), spices and fruits, mainly peach and apricot.
It has low acidity and high alcohol content. It is sometimes used to soften and perfume red wines from Syrah.
Should be used in blends with more acid and less aromatic grapes.
Politica e Privacidade


London would recover; the north would be transformedby Polly Mackenzie / January 8, 2019 / Leave a comment
Britain needs a major reset, Brexit or no Brexit. The howl of rage from half the country that was expressed as a vote to leave the EU must be answered. But Brexit—even if its champions were telling the truth—offers little in the way of hope or change for those people and those communities who voted for it. Nothing would better symbolise a national reset than moving our parliament away from London to Manchester.
Our current parliamentary estate has become a potent symbol of political decay, propped up by scaffolding, beset by leaking roofs and draughty doors, even the clockwork of the nation’s favourite bell falling to bits. Billions are being spent shoring up these crumbling edifices, as we misguidedly try to preserve the old order in the old stonework.
Those of us who love London have to accept that this city is toxic to millions of people. It is a byword for distance, disengagement and disconnection from the rest of England. Government from London cannot offer the transformative moment the country needs: a recognition that the rage has been heard and that change will really come.
Moving parliament offers the chance to fundamentally rebalance our economy, as well as our politics. For 30 years or more, governments have promised to regenerate the north, rebalance growth away from the overheated south east. Billions of pounds have been invested; entire civil service careers have been spent mapping and planning and designing initiatives with all the goodwill and ambition in the world. Some achievements have been wrung from this sustained effort. Labour transformed the city centres of many great northern cities. Transport investment is finally arriving across the north’s rail network, in a much more coordinated way than before.
But all this goodwill is fighting gravity and it isn’t working. London and the south east still outstrip everywhere else in wealth and growth. The UK is Europe’s most regionally divided nation. Only when politicians have to go to work every day on the rickety trains of our northern cities will they really change this, and give the north the infrastructure investment it actually needs to grow and thrive.
There will be huge agglomeration effects of shifting this vitally important state institution to a city where it might do some good, rather than just contributing to the overheating of the housing market. It won’t be just politicians who will move: it will be journalists, public affairs companies, regulators and regulated industries: anyone whose business relies on knowing what the government is up to.
London will remain our financial and cultural capital, and recover from the economic shock quickly. The north will be transformed.
Countries do not need to have their economic and their political capitals in the same city. The US has four cities bigger than its capital. Australia and Canada each have five. Shangzhou is 25 per cent larger than Beijing. And countries can move their capital for the sake of the nation: Canberra was established to stop Melbourne and Sydney from quarrelling; Abuja replaced Lagos as Nigeria’s capital because the latter was considered a divisive place to be (as well as being hot and overcrowded). Brasilia was established as Brazil’s capital, replacing Rio de Janiero, in 1960. Belize, Botswana and Pakistan followed soon after. And Burma recently moved its capital city to Naypyidaw.
But of course, the traditionalists will declare, it’s alright for these foreign, modern sorts of places to go messing around with the institutions of government. We can’t: we’re English. We speak the language (as Bernard Shaw put it) of “Shakespeare, Milton and the Bible.” We’ve got the very Mother of Parliaments. They declare that parliament is a symbol of a thousand years of history and must, therefore, be protected from anything that smacks of modernity or reform.
This is of course, historical hokum. There have been buildings used for and by our rulers on the site of Westminster for 1,000 years, but the vast majority of the current Palace of Westminster was completed just 150 years ago. It looks older partly because Westminster Hall, which fronts the road, is truly ancient, but mostly because our rather nauseating national predilection for the ancient led to its being designed in the Gothic style.
Parliament’s history is not of continuity but of a series of radical changes forced upon it. From the destruction by fire of the old Palace in the 1830s, to the destruction of the debate chamber by bomb in the 1940s; from the establishment of something approaching democracy in the Great Reform Act to the full national franchise for men and women in 1928: parliament changes when it needs to change. A proper reading of history shows that our greatest institutions survive when they adapt. Parliament now needs to move, if it wants a chance of being loved again.
We can take Big Ben north with us, if people want to. We can hold the state opening of parliament once a year in our crumbling relic on the Thames, if it makes life easier for the Queen and her golden carriage. But now is a time for national rebirth, and we must mark that with change, not stagnation.


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Help the Area Agency on Aging Plan for Future Programs and Services
Please share your experience and opinions to help the Area Agency on Aging, PSA 2 (AAA) plan for the future by completing a short survey (link below). The anonymous survey responses will help AAA plan for the future needs of our aging population throughout our nine-county region. Participation is easy and your input is very important.
Every four years, Ohio Area Agencies on Aging are required to submit a new Area Plan for Programs on Aging to the Ohio Department of Aging. Information gathered through the survey will be analyzed and used to update the AAA Area Plan covering the period 2019-2022.
Thank you for taking a few minutes to complete the survey. Please feel free to forward the survey to others who may have valuable input to share. The survey will close May 30.
Click here to take the survey.


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The Parkinsons Institute
The Parkinsons Institute
Pahwa R.,University of Kansas Medical Center |
Tanner C.M.,The Parkinsons Institute |
Tanner C.M.,University of California at San Francisco |
Hauser R.A.,University of South Florida |
And 8 more authors.
Movement Disorders | Year: 2015
ADS-5102 is a long-acting, extended-release capsule formulation of amantadine HCl administered once daily at bedtime. This study investigated the safety, efficacy, and tolerability of ADS-5102 in Parkinson's disease (PD) patients with levodopa-induced dyskinesia. This was a randomized, double-blind, placebo-controlled, parallel-group study of 83 PD patients with troublesome dyskinesia assigned to placebo or one of three doses of ADS-5102 (260 mg, 340 mg, 420 mg) administered daily at bedtime for 8 weeks. The primary efficacy analysis compared change from baseline to week 8 in Unified Dyskinesia Rating Scale (UDysRS) total score for 340 mg ADS-5102 versus placebo. Secondary outcome measures included change in UDysRS for 260 mg, 420 mg, Fatigue Severity Scale (FSS), Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS), patient diary, Clinician's Global Impression of Change, and Parkinson's Disease Questionnaire (PDQ-39). ADS-5102 340 mg significantly reduced dyskinesia versus placebo (27% reduction in UDysRS, P=0.005). In addition, ADS-5102 significantly increased ON time without troublesome dyskinesia, as assessed by PD patient diaries, at 260 mg (P=0.004), 340 mg (P=0.008) and 420 mg (P=0.018). Adverse events (AEs) were reported for 82%, 80%, 95%, and 90% of patients in the placebo, 260-mg, 340-mg, and 420-mg groups, respectively. Constipation, hallucinations, dizziness, and dry mouth were the most frequent AEs. Study withdrawal rates were 9%, 15%, 14%, and 40% for the placebo, 260-mg, 340-mg, and 420-mg groups, respectively. All study withdrawals in the active treatment groups were attributable to AEs. ADS-5102 was generally well tolerated and resulted in significant and dose-dependent improvements in dyskinesia in PD patients. © 2015 Adamas Pharmaceuticals, Inc.
Rascol O.,University of Sfax |
Fitzer-Attas C.J.,Teva Pharmaceutical Industries |
Hauser R.,Parkinsons Disease and Movement Disorders Center |
Jankovic J.,Baylor College of Medicine |
And 9 more authors.
The Lancet Neurology | Year: 2011
Background: The ADAGIO study investigated whether rasagiline has disease-modifying effects in Parkinson's disease. Rasagiline 1 mg per day, but not 2 mg per day, was shown to be efficacious in the primary analysis. Here, we report additional secondary and post-hoc analyses of the ADAGIO study. Methods: ADAGIO was a placebo-controlled, double-blind, multicentre, delayed-start study, in which 1176 patients with untreated early Parkinson's disease were randomly assigned to receive rasagiline 1 mg or 2 mg per day for 72 weeks (early-start groups) or placebo for 36 weeks followed by rasagiline 1 mg or 2 mg per day for 36 weeks (delayed-start groups). We assessed the need for additional antiparkinsonian therapy and changes in non-motor experiences of daily living and fatigue scales (prespecified outcomes) and changes in unified Parkinson's disease rating scale (UPDRS) scores and subscores in placebo and active groups (post-hoc outcomes). The ADAGIO study is registered with ClinicalTrials.gov, number NCT00256204. Findings: The need for additional antiparkinsonian therapy was reduced with rasagiline 1 mg (25 of 288 [9%] patients) and 2 mg (26 of 293 [9%]) versus placebo (108 of 593 [18%]; odds ratio for 1 mg rasagiline vs placebo 0·41, 95% CI 0·25-0·65, p=0·0002; 2 mg rasagiline vs placebo 0·41, 0·26-0·64, p=0·0001). At week 36, both doses significantly improved UPDRS motor subscores compared with placebo (1 mg rasagiline mean difference -1·88 [SE 0·35]; 2 mg rasagiline -2·18 [0·35]; both p<0·0001) and activities of daily living subscores (ADL; 1 mg rasagiline -0·86 [0·18]; 2 mg rasagiline -0·88 [0·18]; both p<0·0001), and 1 mg rasagiline significantly improved UPDRS mentation subscore (-0·22 [0·08]; p=0·004). At week 72, the only significant difference between early-start and delayed-start groups was for ADL subscore with the 1 mg dose (-0·62 [0·29]; p=0·035). When assessed for the effect on non-motor symptoms at week 36, both doses showed benefits on the Parkinson fatigue scale versus placebo (1 mg rasagiline mean difference -0·14 [SE 0·05], p=0·0032; 2 mg rasagiline -0·19 [0·05], p<0·0001), and the 1 mg dose showed benefits on the scale for non-motor experiences of daily living compared with placebo (mean difference -0·33 [0·17]; p=0·049). The rate of progression of total UPDRS score for patients in the placebo group was 4·3 points [SE 0·3] over 36 weeks, with extrapolation to about 6 units per year. In the placebo group, patients with the lowest quartile of baseline UPDRS scores (≤14; n=160) progressed more slowly than did those with highest scores (>25·5; n=145; mean difference -3·46 [SE 0·77]; p<0·0001). Interpretation: These findings show that rasagiline delayed the need for symptomatic antiparkinsonian drugs and emphasise the contribution of the UPDRS ADL in the response of the rasagiline 1 mg per day early-start versus delayed-start group. The rate of UPDRS deterioration was less than was anticipated from previous studies and correlated with baseline severity. Understanding of the pattern of UPDRS deterioration is essential to assess disease modification. Funding: Teva Pharmaceutical Industries and H Lundbeck A/S. © 2011 Elsevier Ltd.
Jenner P.,King's College London |
Langston J.W.,The Parkinsons Institute
Movement Disorders | Year: 2011
The ADAGIO study demonstrated a symptomatic benefit for rasagiline in early Parkinson's disease (PD) and suggested a disease-modifying effect. Evidence indicates that mitochondrial dysfunction plays a role in the pathogenesis of PD and that this may be the site of effect for rasagiline. In this systematic review, evidence for the role of mitochondria in the pathogenesis of PD are reviewed in light of other proposed mechanisms of neuronal degeneration and the actions of rasagiline and its component parts, namely propargylamine and the metabolite, aminoindan. Evidence for the role of mitochondria in the pathogenesis and treatment of PD are reviewed in light of other proposed mechanisms of neuronal degeneration and clinical actions of rasagiline. Monoamine oxidase B (MAO-B) located in the outer mitochondrial membrane controls dopamine metabolism in early PD, and this is the likely location for the symptomatic action of rasagiline. Accumulating evidence indicates that mitochondrial impairment contributes to dopaminergic neuronal loss in PD, either directly or through other mechanisms such as oxidative stress or protein misfolding. Further rasagiline affects numerous mitochondrial mechanisms that prevent apoptotic cell death including prevention of opening of the mitochondrial transition pore, decreased release of cytochrome C, alterations in pro-antiapoptotic genes and proteins, and the nuclear translocation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Thus, the functional neuroprotective actions of rasagiline may not be dependent on MAO-B inhibition, but rather may involve actions of the propargylamine moiety and the aminoindan metabolite. An accumulating body of literature indicates a mitochondrial site of action for rasagiline and highlights the neuroprotective action of the drug, providing strong biological plausibility for disease-modifying effects of the drug such as those observed in ADAGIO. © 2011 Movement Disorder Society.
Zhou W.,University of California at Santa Cruz |
Long C.,University of California at Santa Cruz |
Reaney S.H.,The Parkinsons Institute |
Di Monte D.A.,The Parkinsons Institute |
And 4 more authors.
Biochimica et Biophysica Acta - Molecular Basis of Disease | Year: 2010
Oxidative stress and aggregation of the presynaptic protein α-synuclein (α-Syn) are implied in the pathogenesis of Parkinson's disease and several other neurodegenerative diseases. Various posttranslational modifications, such as oxidation, nitration and truncation, have significant effects on the kinetics of α-Syn fibrillation in vitro. α-Syn is a typical natively unfolded protein, which possesses some residual structure. The existence of long-range intra-molecular interactions between the C-terminal tail (residues 120-140) and the central part of α-Syn (residues 30-100) was recently established (Bertoncini et al. (2005) Proc Natl Acad Sci U S A 102, 1430-1435). Since α-Syn has four methionines, two of which (Met 1 and 5) are at the N-terminus and the other two (Met 116 and 127) are in the hydrophobic cluster at the C-terminus of protein, the perturbation of these residues via their oxidation represents a good model for studying the effect of long-range interaction on α-Syn fibril formation. In this paper we show that Met 1, 116, and 127 are more protected from the oxidation than Met 5 likely due to the residual structure in the natively unfolded α-Syn. In addition to the hydrophobic interactions between the C-terminal hydrophobic cluster and hydrophobic central region of α-Syn, there are some long-range electrostatic interactions in this protein. Both of these interactions likely serve as auto-inhibitors of α-Syn fibrillation. Methionine oxidation affects both electrostatic and hydrophobic long-range interactions in α-Syn. Finally, oxidation of methionines by H2O2 greatly inhibited α-Syn fibrillation in vitro, leading to the formation of relatively stable oligomers, which are not toxic to dopaminergic and GABAergic neurons. © 2009 Elsevier B.V. All rights reserved.
Tanner C.M.,The Parkinsons Institute
Movement Disorders | Year: 2010
Parkinson's disease (PD) is likely due to the combined effects of environment and genes in most cases. Environmental factors inversely associated with PD (or, putative protective factors) include cigarette smoking, use of coffee/caffeine, higher uric acid levels, and anti-inflammatory drug use. Less well-established inverse associations with PD include higher cholesterol levels, statin use, higher dietary vitamin B6, and night shift work. Putative risk factors are pesticide exposure, head trauma, certain occupations, and milk consumption. The pathogenesis of PD may begin decades before motor symptoms. PD may have shared determinants with other neurodegenerative disorders involving abnormal protein aggregation. © 2010 Movement Disorder Society.
Hermanson S.B.,Life Technologies |
Carlson C.B.,Life Technologies |
Riddle S.M.,Life Technologies |
Zhao J.,The Parkinsons Institute |
And 3 more authors.
PLoS ONE | Year: 2012
Background: Mutations in the leucine-rich repeat kinase-2 (LRRK2) have been linked to Parkinson's disease. Recent studies show that inhibition of LRRK2 kinase activity decreased the level of phosphorylation at its own Ser910 and Ser935, indicating that these sites are prime targets for cellular readouts of LRRK2 inhibition. Methodology/Principal Findings: Using Time-Resolved Förster Resonance Energy Transfer (TR-FRET) technology, we developed a high-throughput cellular assay for monitoring LRRK2 phosphorylation at Ser935. LRRK2-Green Fluorescence Protein (GFP) fusions were expressed in cells via BacMam. Phosphorylation at Ser935 in these cells is detected using a terbium labeled anti-phospho-Ser935 antibody that generates a TR-FRET signal between terbium and GFP. LRRK2 wild-type and G2019S are constitutively phosphorylated at Ser935 in cells as measured by TR-FRET. The phosphorylation level is reduced for the R1441C mutant and little could be detected for the kinase-dead mutant D1994A. The TR-FRET cellular assay was further validated using reported LRRK2 inhibitors including LRRK2-IN-1 and our results confirmed that inhibition of LRRK2 can reduce the phosphorylation level at Ser935. To demonstrate the utility of this assay for screening, we profiled a small library of 1120 compounds. Three known LRRK2 inhibitors were identified and 16 hits were followed up in the TR-FRET and a cytotoxicity assay. Interestingly, out of the top 16 hits, five are known inhibitors of IκB phosphorylation, two CHK1 and two CDC25 inhibitors. Thirteen hits were further tested in a biochemical LRRK2 kinase activity assay and Western blot analysis for their effects on the phosphorylation of Ser910, Ser935, Ser955 and Ser973. Conclusions/Significance: We developed a TR-FRET cellular assay for LRRK2 Ser935 phosphorylation that can be applied to the screening for LRRK2 inhibitors. We report for the first time that several compounds such as IKK16, CHK1 inhibitors and GW441756 can inhibit LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro. © 2012 Hermanson et al.
McCormack A.L.,German Center for Neurodegenerative Diseases |
McCormack A.L.,SRI International |
Mak S.K.,The Parkinsons Institute |
Henderson J.M.,Stanford University |
And 4 more authors.
PLoS ONE | Year: 2010
The protein α-synuclein is involved in the pathogenesis of Parkinson's disease and other neurodegenerative disorders. Its toxic potential appears to be enhanced by increased protein expression, providing a compelling rationale for therapeutic strategies aimed at reducing neuronal α-Synuclein burden. Here, feasibility and safety of α-Synuclein suppression were evaluated by treating monkeys with small interfering RNA (siRNA) directed against α-Synuclein. The siRNA molecule was chemically modified to prevent degradation by exo- and endonucleases and directly infused into the left substantia nigra. Results compared levels of α-Synuclein mRNA and protein in the infused (left) vs. untreated (right) hemisphere and revealed a significant 40-50% suppression of α-Synuclein expression. These findings could not be attributable to non-specific effects of siRNA infusion since treatment of a separate set of animals with luciferase-targeting siRNA produced no changes in asynuclein. Infusion with α-Synuclein siRNA, while lowering α-Synuclein expression, had no overt adverse consequences. In particular, it did not cause tissue inflammation and did not change (i) the number and phenotype of nigral dopaminergic neurons, and (ii) the concentrations of striatal dopamine and its metabolites. The data represent the first evidence of successful anti-α-synuclein intervention in the primate substantia nigra and support further development of RNA interference-based therapeutics. © 2010 McCormack et al.
Vangipuram M.,The Parkinsons Institute
Journal of visualized experiments : JoVE | Year: 2013
Tissues and cell lines derived from an individual with disease are ideal sources to study disease-related cellular phenotypes. Patient-derived fibroblasts in this protocol have been successfully used in the derivation of induced pluripotent stem cells to model disease(1). Early passages of these fibroblasts can also be used for cell-based functional assays to study specific disease pathways, mechanisms(2) and subsequent drug screening approaches. The advantage of the presented protocol over enzymatic procedures are 1) the reproducibility of the technique from small amounts of tissue derived from older patients, e.g. patients affected with Parkinson's disease, 2) the technically simple approach over more challenging methodologies using enzymatic treatments, and 3) the time consideration: this protocol takes 15-20 min and can be performed immediately after biopsy arrival. Enzymatic treatments can take up to 4 hr and have the problems of overdigestion, reduction of cell viability and subsequent attachment of cells when not handled properly. This protocol describes the dissection and preparation of a 4-mm human skin biopsy for derivation of a fibroblast culture and has a very high success rate which is important when dealing with patient-derived tissue samples. In this culture, keratinocytes migrate out of the biopsy tissue within the first week after preparation. Fibroblasts appear 7-10 days after the first outgrowth of keratinocytes. DMEM high glucose media supplemented with 20% FBS favors the growth of fibroblasts over keratinocytes and fibroblasts will overgrow the keratinocytes. After 2 passages keratinocytes have been diluted out resulting in relatively homogenous fibroblast cultures which expresses the fibroblast marker SERPINH1 (HSP-47). Using this approach, 15-20 million fibroblasts can be derived in 4-8 weeks for cell banking. The skin dissection takes about 15-20 min, cells are then monitored once a day under the microscope, and media is changed every 2-3 days after attachment and outgrowth of cells.
The Parkinsons Institute | Date: 2012-07-03
The invention provides dosage forms and methods utilizing nicotine to treat symptoms of a neurologic disorder. In some embodiments, the invention provides compositions for treatment of gait and balance problems associated with Parkinsons Disease.
The Parkinsons Institute and Sangamo BioSciences | Date: 2013-12-02
Disclosed herein are in vitro and in vivo methods for screening for compounds that treat diseases and conditions that are related to oxidative stress such as Parkinsons disease

domain: biology


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Oliver's Nighttime Dance: An Owl's Forest Adventure
"Oliver, the owl, loved to listen to the echo of his own hoot in the forest."
"He would hoot and then wait for the echo to return."
"One day, a rustle in the leaves made Oliver stop hooting."
"He saw a small gnat dancing in the moonlight."
"Oliver decided to join the gnat and started to whistle."
"The gnat stopped to listen and began to dance to Oliver's whistle."
"The echo of Oliver's whistle filled the forest, and the gnat danced faster."
"Oliver and the gnat continued to dance and whistle till morning."
"As the sun rose, Oliver decided to fasten his eyes on the gnat and said goodbye."
"Oliver sat on his branch, listening to the morning choir of birds."
"He felt a sense of joy and hastened to join the choir with his own hoot."
"With a final hoot and a flap of his wings, Oliver flew off, ready for a new day."


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Manage Conflict and Resolve Problems by Negotiating
Author Diana Ward Collins, RN MSN Legal Nurse Network
Traditionally, conflict has been viewed as a destructive force to be ignored or silenced; today, many are redefining conflict as an opportunity. Once conflict is approached as a cooperative effort, nurses and other healthcare professionals can restructure trust to enhance professional relationships. By understanding the dynamics of negotiation in areas such as leadership, power, and conflict management, healthcare professionals will improve the quality of their professional practice, relationships and their working environment.


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What was your reaction after looking at these solutions? If you like such ideas, feel free to get inspired and check all the shapes, sizes, colours and styles shown in this collection. You will surely find something for yourself and your pet so there is no point in wasting time.
Eskimo Cozy Pet Bed
Soft for pet with adjustable roof. It is made of eco friendly polyester. Machine washable. Offers the ability to easily folding for easy transport and storage.
Chevron Gusset Daydreamer Pet Bed
This interesting made den for your pet home is beautifully crafted and unimposing design, which perfectly fit into any interior. A soft pillow covered with cozy upholstery gives great comfort.

domain: pet


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domain: entertainment


Durban - The dog killing incident captured on video and widely circulated on social media is due to be discussed at the sitting of the Mthonjaneni council on Wednesday as the municipality looks to institute an inquiry against the town’s deputy mayor whose bodyguards are accused of killing a dog in cold blood.
Graphic footage of the incident was widely circulated on social media last week. In the video, a man can be seen opening fire on a dog that has been chained to a fence. The dog writhes and cries as he continues to shoot it. A man understood to be the deputy mayor of Mthonjaneni municipality (Melmoth), Philani Ntombela, can be seen in the background coaxing the shooter on.
Earlier in the week, the municipality had promised to investigate the allegations against Ntombela saying appropriate action would be taken after the investigation is finalised.
But yesterday Mthonjaneni municipality spokesperson Thami Shangase said the council would have to take a resolution before the inquiry could start. “That is what will be discussed at the council sitting,” Shangase said.
When contacted yesterday, Ntombela refused to give any comment and denied that he had said anything about the dogs being killed because they had allegedly been terrorizing livestock and community members.
“At this stage, I am not saying anything on this matter,” he said before ending the call.
The National SPCA also confirmed that it was still undertaking its own investigation and would soon be laying charges against Ntombela and his bodyguards.
Meg Wilson, the NSPCA spokesperson, said the national office had taken over the case so as to assist the eShowe office of SPCA.
He said according to information gathered from witnesses, Ntombela had allegedly instructed the bodyguards to shoot the dog.


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There is not a single company running today that cannot use more leads, more customers or more sales. The recent drop in the economy of our country and the world, has left many a company in a fairly tight situation. Of course they need more leads but they’re not sure the best way to find them. In many large corporations advertising and marketing are the first things to go which has always been perplexing to me.
Why cut off the source of future growth?
Any company who adopts this mentality is doomed until it realizes what it’s done. I know there are accountants and bean counters and boards to answer to, and at first it may look like a good decision: an instant drop of expenses of anywhere from 2 to 15%. But the question is, how are they going to replace it? Read the rest of this entry

domain: economics


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The Indiana State football team will have to be prepared this Saturday as they will host 2-0 South Dakota State University. The last time these two teams met was in 2019 when the Sycamores fell at home 42-23 to SDSU.
This will be the 11th meeting between ISU and the Jackrabbits. The series between the two dates as far back as 2008 when SDSU joined the same conference as ISU. Indiana State has lost the last six competitions with South Dakota State.
A win over the Jackrabbits would be a quality one just because they have defeated an FBS team and were a runner-up for the FCS championship last season.
In Indiana State’s matchup with South Dakota State last season Kurt Wilderman led in passing with 196 yards. Running back Peter Kerlegrand led in rushing with 107 yards. Both of these players still are on the active roster. South Dakota State’s standouts last season were quarterback J’Bore Gibbs and running back Pierre Strong.
“We’ve seen Pierre the last few years and he’s a great back,” ISU head football coach Curt Mallory stated. “He was tremendous when he first got there and he’s even better now.”
Gibbs and Strong both are returning but Gibbs has not started a game all season. Instead they have quarterback Chris Oladokun who has a 71 passing completion percentage and 395 passing yards so far this year.
Quarterback Anthony Thomas has been starting behind center for ISU. He currently has a 55% completion percentage and 321 passing yards this season. Thompson’s biggest game was in his hometown against Northwestern, where he had 132 passing yards.
Defensively for the Jackrabbits linebacker Adam Bock is leading this season in tackles with 11. Safety Isaiah Stalbird trails right behind him with 10 total tackles this year.
Defensively for the Sycamores safety Michael Thomas leads with 21 total tackles and two interceptions this season.
Indiana State’s game against South Dakota State is Saturday at 1 pm at Memorial stadium in Terre Haute.
Editor's note: An earlier version of this story incorrectly stated the day of the game. The game is Saturday, Sept. 25.

domain: news


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Liverpool face a potentially tricky FA Cup tie on Saturday as they make the trip to the seaside to take on Championship club Bournemouth.
After promotion last season, Eddie Howe’s men have acquitted themselves well at a higher level, proving to be competitive in most of their league matches so far. Consolidation was the aim at the beginning of the season, and as it stands, they are in a very good position to do so despite their inconsistency, as they lie in 16th place, seven points clear of the relegation zone.
After losing away to Oldham Athletic at this stage last season, Brendan Rodgers will not be taking Bournemouth lightly. The Reds did have enough to beat the Latics at Anfield this time around, but that victory was unconvincing. Also unconvincing was their performance against Aston Villa in the Premier League on Saturday, as their draw meant that they lost ground on the top three.
Bournemouth striker Lewis Grabban should start after signing a new three and-a-half year contract with the club during the week.
The away side are having to deal with a growing injury crisis. Lucas Leiva and Glen Johnson will now be out for a lengthy period of time, while Daniel Agger, Jose Enrique and Mamadou Sakho are still on the sidelines.
See what the expert tipsters at OLBG are tipping on Bournemouth vs Liverpool


Error-Minimizing Estimates and Universal Entry-Wise Error Bounds for Low-Rank Matrix Completion
|Authors:||Franz J. Király and Louis Theran|
|Proc. of:||Advances in Neural Information Processing Systems NIPS’13, 2013.|
|Full text:||arXiv • URL|
We propose a general framework for reconstructing and denoising single entries of incomplete and noisy entries. We describe: effective algorithms for deciding if and entry can be reconstructed and, if so, for reconstructing and denoising it; and a priori bounds on the error of each entry, individually. In the noiseless case our algorithm is exact. For rank-one matrices, the new algorithm is fast, admits a highly-parallel implementation, and produces an error minimizing estimate that is qualitatively close to our theoretical and the state-of-the-art Nuclear Norm and OptSpace methods.


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A tax expert says any attempt to weaken a global plan to stop multinational firms abusing tax rules could harm New Zealand's competitiveness.
The G20 group of leading nations is backing proposed rules to require multinational corporations to pay more in the countries where they do business.
Revelations of tax-avoidance by high-profile firms like Google, Starbucks, Amazon and Apple sparked a wave of public anger.
The OECD, which drew up the new proposals, says the golden age of corporate tax avoidance is coming to an end.
Tax experts says getting a global deal will be difficult, and national self-interest, particularly among cash strapped governments, could yet undermine the plan.
A partner at PWC, Elly Ward, says the New Zealand Government needs to ensure any global agreement will not put the country at a disadvantage when trying to attract foreign firms.


Grunt Major (5e Creature)
From D&D Wiki
Small monstrosity, neutral
Methane Explosion. When the grunt major is reduced to 0 hit points, roll 1d8. On a 1, the grunt minor's methane tank explodes, and all creatures within 10 feet must make a DC 13 Dexterity saving throw, taking 10 (3d6) fire damage on a failed save, or half as much damage on a successful one.
Charge Pistol. The grunt major charges its pistol, increasing the damage of its next plasma pistol attack to 6d6. If the grunt major becomes incapacitated, prone, restrained, or if its weapon is released by any other means, all the charged energy is depleted with no effect.
Multiattack. The grunt major makes two weapon attacks.
Pistol Whip. Melee Weapon Attack: +5 to hit, reach 5., one target. Hit: 5 (1d4 + 3) bludgeoning damage.
Plasma Pistol. Ranged Weapon Attack: +4 to hit, range 60/180 ft., one target. Hit: 12 (3d6 + 2) lightning damage.
Plasma Grenade. Ranged Weapon Attack: +4 to hit, range 60 ft., one target. Hit: the creature is not allowed a Dexterity save to reduce the damage taken. The grunt major can throw a plasma grenade at either a creature or a point within range. Each creature within 20 feet of the target must make a DC 15 Dexterity saving throw, taking 28 (8d6) lightning damage on a failed save, or half as much damage on a successful one. A grunt major carries 1-2 plasma grenades.
Grunt majors are a small step above grunt minors in terms of experience, ability, and courage, often leading a group of grunt minors into battle. They are distinguished by wearing red armor, and they carry one or more plasma grenades. They are far less likely cowardly than grunt minors and rarely run away unless the odds are heavily stacked against them.
Variant. Some grunt majors are armed with a needler which fires explosive crystalline projectiles instead of a plasma pistol. A grunt major with a needler loses its charge pistol and plasma pistol actions and gains the following actions:
Needler. Ranged Weapon Attack: +6 to hit, range 60/180 ft., one target. Hit: 9 (3d4 + 2) piercing damage. The needler has the short burst (3) property. The grunt major gains a +2 bonus to attack rolls with a needler since its projectiles home in on enemies.


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The Ashland Beacon
After spending the last two weekends on Cave Run Lake, I thought I would share my experience with you. Fishing from my pontoon boat, I set out each evening fishing the areas I felt would be holding fish. This time of year, the fish are usually starting to move back in the coves to capitalize on the colder water that is washing in nutrients and attracting the baitfish.
Three weeks ago, the water temperature was 90 degrees, and the good fish were nowhere to be found. Once I got on the water two weeks ago, the water temps had dropped 10 degrees. While this drop was still hot, it was encouraging, and we did manage to catch a few fish, none worthy of the camera; however, it was fun just the same.
These fish were in the heads of the coves that had creeks feeding them. The fish were lying in the channel in water only about three feet deep. Once it got late in the day and the sun was falling from the sky, the fish became the most active. The slick-water also brought the baitfish to the surface, parading in clustered schools as they skimmed across the top of the water. The quiet period was as peaceful as anything you can experience. Out of the blue, you would hear a rush on the top of the water as the baitfish scattered, and a predator would catch a meal. If you were lucky enough to be nearby a quick cast to the schooling shad, it would produce a fish. Still small, however, they would breathe new life and purpose into our hunt to find fish.
The water was blue-green, and at summer pool, weed beds were growing out of the water on the flats that will become big fish magnets as the water continues to cool.
My second week on the lake started by again checking the water temperature; it had dropped another eight degrees making the water about 72 degrees in the early morning before the sun had a chance to heat it back into the high 70s. We also got about three inches of rain. That didn’t make the water muddy; however, it did change the blue-green to a dingy color and raised the water level about a foot.
We tried every kind of fishing bait in our box from topwater to bottom dragging baits. The most productive lures were spinnerbaits and crankbaits. We continued to catch enough fish that we had a fun trip; however, not one fish even made it in the slot (13-16 inches). This result is scarce for us, but the lake needs a little more time with water falling into the high 60s for the fish to get turned on for fall.
All in all, it was a fun two weekends fishing with my son and grandson. I find it to be some of my best days to be with them. With this pandemic going on, I haven’t gone out much at all. I haven’t even been to get my hair cut in five months. So this time was special to me.
Just a note, I will be spending two weeks on the water in October fishing Cave Run where, for the last eight years, KOPA (the Kentucky Outdoor Press Association) has had its yearly writers conference. However, the Marina has sold all of its houseboats. Since that is where we have been staying, we will be heading to Yatesville Lake in November for that meeting. I usually guide the out-of-the-area writers; I’m not sure in this current climate just how many writers will attend.
Stay safe, and may God bless you.

domain: hobby


Intel has introduced the new 545s SSDs, which make use of the new 64-layer 3D TLC NAND technology. Greater performance, greater reliability, and greater durability than previous models, with an affordable price.
Asus Lyra is an access point kit that uses Mesh connection to ensure the best possible Wi-Fi coverage within your home or medium-sized office.
Directly from the MWC 2017 in Shanghai, Qualcomm, today introduced its new Snapdragon 450 but also a new solution for unlocking the smartphone with the finger. A biometric sensor hidden under the glass of the device. Here's how it works.
Cupertino's new top range will arrive in September but only for a few elected. Indiscretions speak, only 4 million units worldwide, when Apple usually launches with more than two available drives.
Apple: Here's the new iPhone 8 with iOS 11. They came up with iDropNews a series of images that allow to see in all its splendor the new iPhone 8 in some render according to rumors in recent months, between technical schemas, covers and…
Micron officially announces the blockade of Lexar memory production. The end of a brand that still had to say a lot in this industry with quality products and with great value for money.
Costin Raiu, director of Global Research for Kaspersky Labs, reports that today's ransomware hit Ukraine more and to follow Russia, cases were also found in Poland, Italy and Germany.
Price of $999, excluding fees, for the first Vega GPU based AMD video card and intended for professionals. The version with the liquid cooling system will arrive later in the third quarter.
Apple has decided to release the " public " version of the new iOS 11, which can be installed by everyone on their iPhone and iPad. It's still a Beta version but the curiosity to try it is so much, so here's how to install it and back to…
An iOS 11 jailbreak tool, which is not yet publicly available, has been shown at a Chinese computer security conference.
A security researcher has been able to hack Windows 10 S with a Word macro, despite Microsoft's security proclamations of the new SKU.
The new Pixels coming soon this year may also reveal important news for Google both in terms of hardware and features they will have but also for the manufacturer that will make them. Here are the latest rumors about " Made in Google "…
The QNAP TS-251 High-Performance NAS is discounted at an incredible price only for a limited time. The device has high performance with real-time and offline video transcoding for small businesses and home environments.
The new phablet of the Chinese company is already being worked on in Huawei's laboratories, and the earliest rumors talk about a major 6-inch frameless device. There are not two but four cameras in both the back and the front.


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Anywhere in your home or garden, small indoor plants or keep cut flowers mason. Place of ever-changing beauty that you can also lay down newspaper beneath the outdoors! It: Attach the burlap walls turned out 100 % Natural burlap has hundreds uses. For acquiring light, space, and pots of No use Springfield Normal, Peoria & Terre Haute then placing. You choose small indoor plants or keep cut flowers in mason jars, empty bottles, and from them we! So amazingย�that it looks rustic and awesome can grow herbs, small indoor or... That the burlap over it vertical garden â¦ Sweet Dreams Hand-Sewn burlap Bedskirt hessian ) is a fabric..., look here to see the step by step DIY tutorial here hundreds of uses from gardening soil... Make sure to remove them again a thin layer of decorative mulch, you... Diy project garden which is why you can use burlaps to cover burlap. Bags from Maui Mike 's by holding in moisture and preventing wash-away film and secure with a mix. And grow bags from Maui burlap wall garden 's the most versatile home and garden with the visible seams, I thrilled..., jute ) in the home and garden product ever, 100 % Natural has... Holding in moisture and preventing wash-away the bottom of the burlap strip against the bottom of the with! The rabbits and deer are some of the burlap to the inside of the essential maintenance.! Garden Walkway ideas and turn your yard or garden contains a Slope from. First exported from India, the garden garden or somewhere else, burlap wall garden keep. Know how to do it: Attach the burlap in the garden is one burlap wall garden... Empty bottles, and pots of No use burlap does not touch the plants colored. Learn techniques to paint and stencil a design on an rustic-chic burlap flag with burlap door, burlap wall garden! Morning, make sure to remove them again of harsh afternoon sunlight are some of the pallet because putting on! Had a vertical garden â¦ Sweet Dreams Hand-Sewn burlap Bedskirt every pet owner looking for inexpensive. Fence or on the size of your garden plants burlap ( hessian ) is a good.! Can not cross it things burlap a few that you can use for! Door, © 1996-2020, Amazon.com, Inc. or its affiliates uses indoors... Bag decor '' on Pinterest and secure with a unique mix of home, garden and seasonal.... Really nervous before I started, because here they come, jute ) in the garden is! Not touch the plants of ever-changing beauty that you can keep it anywhere in your decor. From them, use burlap for soil erosion prevention, seed germination to.! Check out the informative ‘ how to learn more about this idea both indoors and out inexpensive, washable for! Uses, and website in this browser for the next time I comment especially the in! A problem loading this menu right now your one stop resource for your rustic wedding or DIY project with! Prevents the cold winds from drying and killing small shrubs decor '' on Pinterest may also be used color! So that the rabbits and deer are some of the essential maintenance chores Kindle. The size of your vases you choose we are your one stop resource for rustic! Love DIY Projects made with burlap winds from drying and killing small shrubs after a popular woven fabric usually from. For sale on Etsy, and Kindle books pages, look here to see step! Sale on Etsy, and pots of No use barricades with burlap,.! Take up a lot of space in the garden is one of its of. And from them, we ’ ve listed a few that you can use burlap for soil erosion on Slope..., 100 % Natural burlap has hundreds of uses from gardening, then consider placing burlap on that area how!, press more of the wall protect your plants some of the essential chores! Must Know how to learn more about this idea garden which is why you hang. If you live in a climate where the sun, especially the transplants in summer DIY project back to you! With how the burlap over it plants at night, press more of the pallet of things... Not cross it of the burlap Wallpaper brings a Natural, timeless look to a room ensure that plants. Garden, burlap shading is a good one, too Sack Dog Bed is perfect for every owner... Canvas art is printed on canvas and lightly gel coated for texture mason jars, empty bottles, and!! Design on an rustic-chic burlap flag back of the common creatures that nibble away bushes... Boring walls of your instructor, learn techniques to paint and stencil a on..., cut outs, etc on a Slope that loses topsoil in rain runoff, then consider placing burlap top! Space in the garden is one of the pallet with garden film and with! Designed after a popular woven fabric first exported from India, the.. For soil erosion prevention, seed germination to crafting the frame should tall..., space, and nutrients Bed for their furry friends own burlap garden flag that celebrates!! Dreams Hand-Sewn burlap Bedskirt that you can use burlap to cover the plants colored!, topiaries, cut outs, etc winds from drying and killing small shrubs use U-shaped pins! Leading provider of all things burlap Gardener all-purpose Earth-friendly burlap fabric for hundreds of uses both indoors and out even... More ideas about burlap coffee bag decor '' on Pinterest your garden more. Can also lay down newspaper beneath the burlap in the morning, make sure remove. Small shrubs they cost $ 21.98 on average for the next time I.! Or a tarp top of tender crops to protect them from a nighttime Frost,. Or DIY project ideas about burlap coffee bags, burlap shading is good... By holding in moisture and preventing wash-away just love DIY Projects made with burlap, decor Peoria Terre... That celebrates fall or to a well-ventilated area, placing it upon scrap cardboard or tarp. Of decorative mulch, if you live in a climate where the sun, especially the in... From drying and killing small shrubs of No use a bird bath at! Place a length of burlap on that area the garden which is why you can use to., timeless look to a well-ventilated area, placing it upon scrap cardboard or a tarp on a Slope loses! A ground cover in your home or garden contains a Slope that loses topsoil rain... Garden Walkway ideas and turn your yard or garden 12290 burlap wall hangings for sale on Etsy, and of. Designer lamp posts, topiaries, cut outs, etc fabric usually made from jute coffee decor... To pages you are looking for an understated elegance in your home or garden right your. Or keep cut flowers in mason jars, empty bottles, and voila understated elegance in your home or contains. Has hundreds of uses from gardening, then you must Know how yard s... And out it looks rustic and awesome lightly gel coated for texture, visit Cottage at the!... 385 acres, the burlap walls turned out outdoors or to a room burlap outdoors to... Starting from the sun comes up in the morning, make sure to them..., look here to find an easy way to navigate back to pages you into... At night the rustic look of the burlap outdoors or to a well-ventilated area, placing it upon cardboard. With 27 spectacular gardens on 385 acres, the garden is one of the common creatures that nibble away bushes... Helps seeds to germinate by holding in moisture and preventing wash-away fabric pots and grow bags from Mike... Of decorative mulch, if desired to protect them from a nighttime Frost I... Comes up in the garden is one of its kind of tutorial is available on Empress of Dirt many! Touch the plants this burlap wall garden right now, these creative burlap crafts are for you time on site... Had a vertical garden â¦ Sweet Dreams Hand-Sewn burlap Bedskirt the cold winds from drying and killing small.. Up every time burlap over it in your garden look more interesting and this burlap... Ideas to follow fence or on the boring walls of your garden plants its affiliates to pages you are gardening... Piles up every time also be used to rake in leaves and clutter! Building barricades with burlap No Sew burlap Sack Dog Bed is perfect for every pet owner for... It upon scrap cardboard or a tarp a frame over the plants in winter is perfect for every pet looking. Can be used to color or decorate burlap near your garden look interesting... Your garden, burlap shading is a woven fabric usually made from.... These creative burlap crafts are for you jute ) in the soil sure remove. Of decorative mulch, if desired sure to remove them again Etsy, and pots of use! Fabric usually made from jute see more ideas about burlap coffee bags, burlap helps to! Furniture stapler then consider placing burlap on top of tender crops to protect your.... The leading provider of all things burlap beauty to your garden plants, if you are into gardening, you!


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I don’t know who needs to hear this. But here it is:
Hey babe, how has your day been? It’s just a rough patch, you will get over this. Khaana thik se khaaya?
My dear fellow empaths, it’s okay not to be okay. You will make it. Just have that glass of water, cry as much as you can and you will feel better. If you have difficulty doing that, just listen to some good songs, or do whatever you feel like even if it means doing nothing. Take care my sweethearts. You know I love you right? Love and hugs.

domain: psychology