text:
|Publication number||US20040142389 A1|
|Application number||US 10/751,699|
|Publication date||Jul 22, 2004|
|Filing date||Jan 5, 2004|
|Priority date||Nov 19, 1998|
|Also published as||US6699973|
|Publication number||10751699, 751699, US 2004/0142389 A1, US 2004/142389 A1, US 20040142389 A1, US 20040142389A1, US 2004142389 A1, US 2004142389A1, US-A1-20040142389, US-A1-2004142389, US2004/0142389A1, US2004/142389A1, US20040142389 A1, US20040142389A1, US2004142389 A1, US2004142389A1|
|Inventors||Daniel O'Mahony, Michela Seveso|
|Original Assignee||O'mahony Daniel Joseph, Michela Seveso|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (2), Referenced by (6), Classifications (15), Legal Events (2)|
|External Links: USPTO, USPTO Assignment, Espacenet|
 The present invention relates to antibodies to random peptides capable of targeting or specifically binding to gastro intestinal tract (GIT) transport receptors. In particular, this invention relates to methods of using these antibodies as well as specific antibody preparations directed to particular GIT random peptide targeting agents.
 Antibodies can be produced by using an immunogen to generate antibodies which immunospecifically bind such an immunogen. Such antibodies include but are not limited to polyclonal, monoclonal, chimeric, single chain, Fab fragments, and an Fab expression library.
 Various procedures known in the art may be useful for the production of polyclonal antibodies to an immunogen. For the production of antibody, various host animals, such as rabbits, mice, rats, fowl etc. can be immunized by injection with the immunogen. Various adjuvants may be used to increase the immunological response, depending on the host species, such as Freund's (complete and incomplete), mineral gels such as aluminum hydroxide, surface active substances such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanins, dinitrophenol, and potentially useful human adjuvants such as BCG (bacille Calmette-Guerin) and corynebacterium parvum.
 As disclosed and claimed in WO 98/51325, which reference is hereby incorporated by reference in its entirety, we have identified random peptides and their fragments, motifs, derivatives, analogs or peptidomimetics thereof which are capable of specific binding to GIT transport receptors such as the D2H, hSI, HPT1 and hPEPT1 receptors (hereinafter referred to as “GIT targeting agents”). These GIT targeting agents are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue and have use, for example, in facilitating transport of active agents from the lumenal side of the GIT into the portal, hepatic or systemic blood system and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) the GIT targeting agent to an orally administered active agent, the active agent can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastrointestinal tract, thus facilitating its absorption into the systemic system. Preferably, the active agent is a drug or a drug-containing nano- or microparticle. Preferably, the tissue through which transport is facilitated is of the duodenum, jejunum, ileum, ascending colon, transverse colon, descending colon, or pelvic colon. The tissue is most preferably epithelial cells lining the lumenal side of the GIT.
 The GIT targeting agents are bound to a material comprising an active agent. Such compositions have use in targeting the active agent to the GIT and/or in facilitating transfer through the lumen of the GIT into the systemic circulation. Where the active agent is an imaging agent, such compositions can be administered in vivo to image the GIT (or particular transport receptors thereof). Other active agents include but are not limited to: any drug or antigen or any drug- or antigen-loaded or drug- or antigen-encapsulated nanoparticle, microparticle, liposome, or micellar formulation capable of eliciting a biological response in a human or animal. Examples of drug- or antigen-loaded or drug- or antigen-encapsulated formulations include those in which the active agent is encapsulated or loaded into nano- or microparticles, such as biodegradable nano- or microparticles, and which have GIT targeting agents adsorbed, coated or covalently bound, such as directly linked or linked via a linking moiety, onto the surface of the nano- or microparticle. Additionally, the GIT targeting agent can form the nano- or microparticle itself or the GIT targeting agent can be covalently attached to the polymer or polymers used in the production of the biodegradable nano- or microparticles or drug-loaded or drug-encapsulated nano- or microparticles or the peptide can be directly conjugated to the active agent.
 The GIT targeting agent bound to the active agent can be employed in methods of treatment (and prophylaxis) by administration to a subject of an effective amount of targeting agentactive agent. Any disease or disorder of interest amenable to therapy or prophylaxis by providing a drug in vivo systemically or by targeting a drug in vivo to the GIT (by linkage to a GiT targeting agent) can be treated or prevented by this administration. Any route of administration known in the art may be used, including but not limited to oral, nasal, topical, intravenous, intraperitoneal, intradermal, mucosal, intrathecal, intramuscular, etc. Preferably, administration is oral.
 However, to fully characterize the compositions as well as to determine the fate of the compositions following administration to a subject, antibodies to the specific GIT targeting agents are needed.
 The present invention provides antibodies or antibody fragments specific to a domain of a GIT targeting agent, particularly antibodies to ZElan033 (PAX2 15 mer), ZElan088(HAX42-2 20 mer) and ZElan053 (P31 D-form 16 mer).
 Additionally, numerous methods are provided below that employ the GIT targeting agent specific antibodies of this invention, including methods of detecting, quantitating, and locating the GIT targeting agent either in a pharmaceutical composition or after contact of a GIT targeting agent-containing composition with human or animal gastrointestinal tissue.
FIG. 1 shows the immuno responses of three groups of 2 rabbits, each group immunized, respectively, with one of KLH conjugated ZElan033, KLH conjugated ZElan088 and KLH conjugated ZElan053, when the fourth bleed samples are tested by ELISA on their respective unconjugated peptides;
FIG. 2 shows the crossreactivity of rabbit antisera for three goups of 2 rabbits, each group immunized, respectively, with one of KLH conjugated ZElan033, KLH conjugated ZElan088 and KLH conjugated ZElan053, when the fourth bleed samples are tested by ELISA on each of synthetic peptides HAX42.2, PAX2 15 mer and P31-D-form;
FIG. 3 shows the immuno-reactivity of anti-HAX42-2 antisera (fifth bleed samples) on a variety of synthetic peptides;
FIG. 4 shows the immuno-reactivity of anti-PAX2 antisera (fifth bleed samples) on a variety of synthetic peptides; and
FIG. 5 shows the immuno-reactivity of anti-P31 D-form antisera (fifth bleed samples) on a variety of synthetic peptides.
 According to this invention, a GIT targeting agent may be used as an immunogen to generate antibodies which immunospecifically bind such an immunogen. Such antibodies include but are not limited to polyclonal, monoclonal, chimeric, single chain, Fab fragments, and a Fab expression library. Particular antibodies provided by this invention include but are not limited to antibodies or antibody fragments, preferably polyclonal antibodies or antibody fragments, specific to a domain of GIT targeting agents ZElan033 (PAX2 15 mer), ZElan088 (HAX42-2 20 mer) and ZElan053 (P31 D-form 16 mer). Additional GIT targeting agents are disclosed throughout the above-referenced WO 98/51325.
 These antibodies can be used in methods relating to the localization and activity of the GIT targeting agent sequences, e.g., for imaging these peptides after in vivo administration (e.g., to monitor treatment efficacy), measuring levels thereof in appropriate physiological samples, in diagnostic methods, etc. For instance, antibodies or antibody fragments specific to a domain of a GIT targeting agent, such as a dansyl group or some other epitope introduced into the peptide, can be used to 1) identify the presence of the peptide on a nanoparticle or other substrate; 2) quantify the amount of peptide on the nanoparticle; 3) measure the level of the peptide in appropriate physiological samples; 4) perform immunohistology on tissue samples; 5) image the peptide after in vivo administration; 6) purify the peptide from a mixture using an immunoaffinity column, 7) bind or fix the peptide to the surface of nanoparticle or 8) when a tag is also added to either an active-agent containing particle or the active agent itself, track the fate of both the particle/active agent and the GIT targeting agent so as to determine if and/or where they become separated. Use 7 above envisions attaching the antibody (or fragment of the antibody) to the surface of drug-loaded nanoparticles or other substrates and then incubating this conjugate with the peptide. This procedure results in binding of the peptide in a certain fixed orientation, resulting in a particle that contains the peptide bound to the antibody in such a way that the peptide is fully active. Additionally, antibodies or antibody fragments specific to a domain of a GIT targeting agent 9) can be used in confocal microscopy imaging techniques or other imaging techniques in order to demonstrate or confirm or identify the location or localization of the peptide on the surface of a nano- or microparticle, 10) can be used in confocal microscopy imaging techniques or other imaging techniques in order to demonstrate or confirm or identify the location or localization of the p ptide on the surface of a nanoparticle or microparticle which has also been loaded with a fluorescent agent, 11) in the case of nanoparticles or microparticles coated with the peptide which have been sliced into two halves by a microtone or other suitable techniques, the antibody can be used in suitable quantitative techniques such as confocal microscopy imaging techniques or other quantitative imaging techniques in order to identify or quantitate the relative distribution of the peptide between the surface of the nanoparticle or microparticle and the sub-surface interior matrix of the nanoparticides or microparticles, 12) can be used in confocal microscopy imaging techniques or other imaging techniques in order to demonstrate or confirm or identify the location of a peptide on the surface of a nanoparticle or microparticle which has been loaded with a fluorescent agent such as TRME or fluorascene, 13) can be used to identify which epitope or domain of the peptide is responsible for identification by the antibody; peptide derivatives such as cyclic forms or derivatives containing intra-chain disulphide bonds or other intra-chain bonds can also be used in mapping studies in order to identify which domain or epitope of the peptide is responsible for recognition by the antibody; 14) in the case of peptide derivatives in which the epitope or domain responsible for binding to a target receptor is flanked by di-sulphide bond or other intra-chain bonds and in which this domain is also responsible for binding to the antibody, the antibody can be used to determine if that epitope or domain is exposed or available for binding to the antibody when the peptide or derivative is coated onto the surface of a nanoparticle, microparticle or other substance, 15) can be used where the epitope or domain on the peptide which binds to the target receptors in the human gastrointestinal tract or the target receptors on model epithelial cells such as Caco-2 cells or polarised Caco-2 cells and where this epitope or domain on the peptide is also responsible for binding by the antibody, the antibody can be used in competition studies to compete for the binding of the peptide to its target receptor sites and 16) where the epitope or domain on the peptide which binds to the target receptors in the human gastrointestinal or the target receptors on model epithelial cells such as Caco-2 cells or polarised Caco-2 cells and where this epitope or domain on the peptide is also responsible for binding by the antibody, the antibody can be used in competition studies in which nanoparticles or microparticles are coated with the peptide and are used in cell binding studies and/or in receptor binding studies.
 Polyclonal antibodies against the GIT targeting agents PAX2 15mer, HAX42-2 20mer and P31 D-form 16mer were raised to allow for, among other uses as discussed above, following the destiny of particles coated with peptides in in vivo models. These three GIT targeting agents were selected for their ability to bind in vitro to Caco-2 P100 fraction and, when coated on the surface of insulin loaded nanoparticides, to enhance insulin delivery in in vivo studies (rat model/intra-duodenal). The primary sequences for these three GIT targeting agents are given in Table 1.
TABLE 1 N° OF AMINO NAME SEQUENCE ACIDS ZELAN033 K(dns)-TNAKHSSHNRRLRTR PAX2 15 mer ZELAN088 K(dns)-SDNAKEPGDYNCCGNGNSTG HAX42-2 20 mer ZELAN053 K(dns)-TrKSSrSNPrGrrHPG P31 D form 16 mer
 The peptides were synthesised (Genosys) and conjugated to KLH protein in preparation to immunise rabbits. KLH protein was conjugated at both N- and C-terminals in order to maximise the probability of obtaining specific antibodies.
 The immunization protocol provided that two rabbits were immunized for each peptide; Rabbits 122 and 123 were immunized with PAX215 mer, Rabbits 120 and 121 were immunized with HAX42-2 20 mer and Rabbits 141 and 142 were immunized with P31 D-form 16m r. The initial immunisation was given in Complete Freund's adjuvant and the remaining boosts in Incomplete Freunds. A pre-immune sample was taken from each animal before immunization. The rabbits were injected at day 0, day 14 and 28, bled a week later at day 35 (1st bleed), boosted a week later at day 42 and bled a week later at day 49; this sequence of injections and bleeds was performed every two weeks.
 The bleed samples were tested by ELISA using the following procedures: 96 well plates were coated with peptide at 50 μg/ml in 0.05M carbonate/bicarbonate buffer, pH9.6, overnight. The plates were washed twice with PBS+0.05% Tween20 and the plates were blocked with 2% dried skimmed milk (99% fat free) in PBS for one hour at room temperature. The plates were then washed three times with PBS+0.05% Tween20 and anti-sera diluted in 2% dried milk-PBS was added followed by incubation for one hour at room temperature. The plates were then washed three times with PBS+0.05% Tween20 and secondary antibody goat anti-rabbit IgG-HRP (Sigma A0545, dilution 1:20000) in 2% dried milk-PBS was added followed by incubation for one hour at room temperature. The plates were washed three times with PBS+0.05% Tween20, TMB substrate was added, incubated and the absorbance was read at 650 nm.
 The fourth bleed samples were tested by ELISA on both the peptides used for immunisation (but not conjugated to KLH) and on different (dansylated) peptide batches. Pre-immune serum was included in the assay as negative control and background binding to plastic was also tested. As shown in FIG. 1, the antisera of the immunised rabbits gave an antibody response compared to pre-immune sera of the same animals. The immuno response of the two rabbits immunised in each protocol was comparable except that Rabbit 120 showed a lower antibody titer with respect to Rabbit 121. Crossreactivity of each rabbit antiserum on different peptides was also analysed by ELISA as shown in FIG. 2 and no significant cross-reactivity was detected.
 The fifth bleed samples were tested by ELISA as described above and examples of the profiles obtained are shown in FIGS. 3, 4 and 5. A higher titer of antibody was detected for each rabbit after this longer immunisation period compared to the fourth bleed results.
FIG. 3 shows the immuno-reaction of anti-HAX42 antisera on synthetic peptides (sequences reported in the Figure). Panel A shows the ELISA results for rabbit #120 antisera: good immuno-response is obtained on unconjugated peptide Used as antigen but no response was obtained for the same peptide conjugated to a dansyl group (Zelan088). No immuno-response is observed for the other peptides analysed. Panel B shows the ELISA results for rabbit #121 antisera: in this case there also was good immuno-response for the unconjugated peptide used as antigen but no response for Zelan088 dansyl-peptide. Rabbit #121 antisera is positive (although less strongly) against Zelan021 (HAX42) and Zelan071 (HAX42 29mer derivative).
 Panel C shows the response of anti-dansyi IgG on the peptides used in the assay.
FIG. 4 shows the immuno-reactivity of anti-PAX2 antisera on synthetic peptides. Rabbit #122 (panel A) and #123 (panel B) have a different immuno-response. Both antisera react in the same way to the unconjugated peptide (=Zelan033) used for immunisation. Rabbit #123 antisera has also very strong reactivity against Zelan103A peptide whereas rabbit #122 does not bind to the same peptide. Rabbit #123 antisera has also imuno-response against both Zelan104 and Zelan018. Panel C shows the response of anti-dansyl IgG on the peptides used in the assay.
FIG. 5 shows the immuno-reactivity of anti-P31 D-form antisera on synthetic peptides. Both rabbit #141 and #142 react equally well on P31 D-25 form unconjugated peptide (=Zelan053). No reactivity is present against all the other peptides tested.
 Table 2 provides a summary of the fifth bleed results.
TABLE 2 Rabbit Number Peptides Unconjug. antigen Zelan021 Zelan071 Zelan088 (=Zelan088) (HAX42) Rabbit 120 − − − + Rabbit 121 + +/− −/+ ++ Unconjug. antigen Zelan018 Zelan104 (=Zelan033) Zelan103A (PAX2) Rabbit 122 −/+ −/+ + − Rabbit 123 + + + ++ Unconjug. antigen Zelan024 (=Zelan053) Zelan054 Zelan145 (P31 d-form) Rabbit 141 − + − − Rabbit 142 − + − −
 The present invention is not to be limited in scope by the specific embodiments described herein. Indeed, various modifications of the invention in addition to those described herein will become apparent to those skilled in the art from the foregoing description and accompanying figures. Such modifications are intended to fall within the scope of the appended claims.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US6232287 *||Mar 13, 1998||May 15, 2001||The Burnham Institute||Molecules that home to various selected organs or tissues|
|US7056734 *||Aug 10, 1999||Jun 6, 2006||The United States Of America As Represented By The Department Of Health And Human Services, Nih||Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or exendin-4 and uses thereof|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US7964577||Oct 16, 2006||Jun 21, 2011||Donald Carlton D||Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy|
|US8088603||Jan 16, 2008||Jan 3, 2012||Phigenix, Inc.||Compositions and methods for diagnosing, treating, and preventing prostate conditions|
|US8445444||Oct 26, 2011||May 21, 2013||Phigenix, Inc.||Compositions and methods for diagnosing, treating, and preventing prostate conditions|
|US8623617||Sep 7, 2012||Jan 7, 2014||Phigenix, Inc.||Detecting PAX2 for the diagnosis of breast cancer|
|US8722367||Sep 7, 2012||May 13, 2014||Phigenix, Inc.||Detecting PAX2 for the diagnosis of breast cancer|
|WO2011025475A1 *||Aug 25, 2009||Mar 3, 2011||Phigenix, Inc.||Detecting pax2 for the diagnosis of breast cancer|
|U.S. Classification||435/7.2, 530/388.26|
|International Classification||C07K14/47, C07K16/18, C07K5/11, C07K14/82|
|Cooperative Classification||C07K16/18, C07K14/82, C07K14/47, A61K2039/505, C07K5/1019|
|European Classification||C07K14/47, C07K5/10B, C07K16/18, C07K14/82|
|Mar 12, 2009||AS||Assignment|
Owner name: GE BUSINESS FINANCIAL SERVICES INC., CONNECTICUT
Free format text: SECURITY AGREEMENT;ASSIGNOR:AXCELL BIOSCIENCES CORPORATION;REEL/FRAME:022390/0106
Effective date: 20090224
|Feb 3, 2010||AS||Assignment|
Owner name: AXCELL BIOSCIENCES CORPORATION,UNITED KINGDOM
Free format text: RELEASE OF SECURITY (R/F 022390/0106);ASSIGNOR:GE BUSINESS FINANCIAL SERVICES INC. (FORMERLY KNOWN AS MERRILL LYNCH BUSINESS FINANCIAL SERVICES INC.);REEL/FRAME:023890/0611
Effective date: 20100128


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Big news: It's official, the Insiders Club is now open! Find out all about the perks of being a member here. Plus: If you join today, you’ll get a special launch rate. Doors are open until June 3rd. Join the club!
Serene and elegant are often the words used to describe interiors featured on this site. But what about joyful? Here, I am showing you exactly that – A playful yet understated decor with a pop of colors and graphic elements that give this place happy energy.
I previously admitted being somewhat color shy when it comes to decorating my home, but it is impossible not to be seduced by the look & feel of this place. It strikes a great balance between cozy and curated, with an artsy, warm, and personal vibe.
I also like that the decor is a lovely blend of ‘New Nordic’ and vintage. There are a lot of furnishings from Hay, Artek, Menu, String, Marimekko, Iittala, and many other Scandinavian brands. You’ll also notice a lovely collection of ceramic and beautiful prints, which add to the uniqueness of the home.
Beautiful, isn’t it?
It is the home of Münster-based Swantje Hinrichsen, a graphic designer, illustrator, and interior stylist. If you are looking to add a lovely dose of sunshine and creativity to your Instagram feed, head over to her account!
Photos: Swantje Hinrichsen with thanks
Hey! See that bookmark button just above? This is one of the many exclusive perks of being a member of the Insiders Club! Doors close on June 3, 2020 - Don't miss out!

domain: artistic


text:
Personal Injury Lawyer | Great Lawyer Traits
Personal Injury Lawyer | Key traits of a great personal injury lawyer are:
The trait that defines a great personal injury lawyer is compassion. Great lawyers care about their clients. They understand the pain and suffering that their clients endure. Because they empathize with injury victims, they are able to communicate that suffering to juries and to insurance adjusters.
Clients refer friends to great personal injury attorneys not only because those lawyers achieve excellent results, but because they treat clients with dignity and respect. Great lawyers view their clients as people, not as sources of fees. Outstanding personal injury lawyers care about achieving justice for injury victims more than they care about money. They want clients to receive fair compensation so that clients can rebuild their lives, get the medical care they need, and overcome their injuries to the greatest possible degree.
Great lawyers talk to their clients. The number one complaint about lawyers is that they ignore their clients. They fail to return telephone calls. They never answer emails. It takes weeks to get an answer to a simple question. The lawyer might be doing a good job for his or her clients but the clients are frustrated because they do not know what is happening with their cases.
Great personal injury lawyers keep their clients fully informed. They send copies of every letter they write on the client’s behalf. They give clients regular progress reports. They return telephone calls and respond to emails promptly. If they are busy with a trial, they make sure that a paralegal or secretary gets back to the client and relays an answer or tells the client when the attorney will be available. Clients know that great lawyers are working hard on their behalf because great lawyers communicate with their clients.
Since 1989, the personal injury lawyers of Clekis Law Firm have been representing injured people and their families in Charleston and throughout the Low Country. At the Clekis Law Firm our clients always come first. If you or a loved one has suffered a serious personal injury due to the negligence of another, don’t be victimized twice. You need someone on your side to help you with your personal injury case and obtain the fair and reasonable compensation that you deserve. Call Clekis at 843.779.1160!
For more information, Like us on Facebook!

domain: law


text:
Susan Crawford blogs about John Markoff’s new book, What the Dormouse Said, which draws an intriguing connection between the San Francisco Bay Area counterculture and the origins of “personal” computing during the 1960s, particularly on the mid-Peninsula. Susan draws this conclusion: “[S]ometimes it’s a good idea to just do things. Go ahead — today — and build something useful and imaginative. People will write about you later. ”
I’ll have to pick up Markoff’s book (and add it to the summer reading list), but my reaction is a little different. He reminds us to be attuned to the material conditions that accompany what we think of creativity and imagination. The counterculture of the mid-Peninsula was a heady but tiny thing during the 1960s. The “Silicon” Valley didn’t exist, and the “Santa Clara” Valley lay somewhere to the South of Palo Alto. The Grateful Dead and Ken Kesey occupied an outpost in Menlo Park pioneered by Thorsten Veblen (more on Veblen, Kesey, and Garcia, here), which was, despite its central location, beyond the domain of most “ordinary” government regulation. Importantly, in unincorporated Menlo Park, the police didn’t patrol on a regular basis.
For a glimpse of what the non-counterculture life was like in most of the mid-Peninsula during the 1960s and early 1970s (in other words, what life was like for most people), read George Packer’s excellent Blood of the Liberals, or (into the mid and late 1970s) Jeff Goodell’s Sunnyvale.
The lesson, then, may be not so much about a “public” domain or about making sure that people exercise their imaginations. The lesson may be that if we want to enjoy the fruits of creative fermentation, we need to maintain, in some way, uncontrolled corners of the world.

domain: literature


What’s next for ... Advance Auto Parts?
Higher gas prices and a rebound in new car sales don’t seem to worry auto-parts retailer
- April 29, 2011
Roanoke-based Advance Auto Parts Inc. did well during the slumping economy. During the downturn, many consumers kept and repaired their cars rather than buying new vehicles. The auto-parts retailer is now positioning itself to take advantage of a long-awaited recovery in consumer spending.
During 2010, Fortune 500 the company saw sales rise for the fifth consecutive year to $5.9 billion, while operating income jumped to almost $585 million and net income rose to $346 million — two metrics that have increased three times in the last four years.
In recent conversations with investors, company CEO Darren Jackson said prospects for continued growth in the next few years are strong. He plans to increase investment in the rapid delivery of parts to commercial clients, provide more intense customer-friendly service training for all sales associates and drive managers to raise the company’s average annual store sales from $1.6 million a year to $2 million.
Skeptics say rising gasoline prices and the recent rebound in new car sales could slow Advance Auto’s growth. Jackson, however, argues that the impact from either factor will be minimal. Higher gasoline prices may slow traffic to stores (since motorists will drive less and need fewer replacement parts), but they really won’t become a serious threat to revenue until crude oil returns to 2008 levels of about $150 a barrel, he says.
“We’ve learned to adapt and adjust in spite of any major change in the economy,” says James Wade, Advance Auto’s president. “Consumers will continue to be challenged by high unemployment and having less to spend. . .we can help them work their way through those issues.”
Morningstar analyst Zoe Tan agrees, writing earlier this year, “Although we expect demand for automotive parts to moderate as new car sales improve from record lows over the next few years, we remain optimistic about the long-term outlook … Despite cyclical swings in the industry, the aftermarket parts industry has proven to be relatively stable over the long haul.”
According to Jackson, U.S. motorists buy about $60 billion a year in auto parts, with $40 billion sold through professional mechanics and the rest purchased by do-it-yourselfers who work on their own cars either as a hobby or to save money. Right now, 66 percent of Advance Auto’s sales are to do-it-yourself customers, with commercial customers making up the other 34 percent. Jackson eventually wants to achieve a 50-50 balance.
He’s been able to raise Advance Auto’s share of commercial sales nationwide to about 4 percent of the market. That was the result of double-digit sales gains in each quarter since 2008 as the company added commercial sales and delivery capabilities to about 90 percent of the company’s more than 3,600 stores.
Advance Auto, which by its own admission had no viable Internet presence until 2009, now hopes an improved website and online ordering by commercial customers will help the company cut into the 10-year head start in e-commerce held by rival chains, including NAPA, O’Reilly, AutoZone and Pep Boys. Jackson sees commercial sales as a growth engine. “We’re going into 2011 with a set of capabilities that we have not had historically,” he said in March. Adds Wade, “If we don’t have a part in a particular store, we’ll can get it for you in 30 minutes.”
While giving an increased focus to commercial customers, the company has unveiled a new national marketing campaign, titled “Service is the Best Part,” to protect the 20 percent share it says it holds of the do-it-yourself market. The campaign is designed to leverage the company’s service offerings for those motorists who can’t, or won’t, perform the simplest of auto repairs.
For many years, AutoZone has offered free replacement of batteries and wiper blades at their stores. Currently, about 100 Advance Auto stores are experimenting with something extra: delivering a variety of replacement parts to homes and performing some installation services on-site. “We are seeing customers respond very positively to this experience.” says Wade. “It comes down to serving the customer.”


text:
Revisión de TripAdvisor
Basado en 468 reseña
Situated right off the Interstate-5 in downtown Corning, this hotel is the perfect lodging for both tourists and those traveling through Northern California. Hotel guests will find themselves close to the Sacramento River Woodson Bridge offering boating, fishing and picnic areas. Nearby 24- hour cas...

domain: geography


text:
Andy Sotiriou, works on sale
Londres (Reino Unido), 1960
The London photographer Andy Sotiriou found in photography the perfect mean of expression to combine his interest in art and science. Though he graduated in Physics, he soon realised that his real vocation was art. His first steps as an artist started with pictures of great musicians for the discographic companies, to make album covers and publicity material. In the 80's he began to travel throughout Europe and the United States, which allowed him to encourage his archive of commercial and travel images. In the 90's he moved to Spain where he lives between Murcia and Madrid. Today, he works on his personal projects making printings and exhibitions. He counts on several solo and collective exhibitions.


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Iranian National Cord Blood Bank
Iranian National Cord Blood Bank was established in May 2010. It is a public blood bank with the mission of providing stem cells for patients.
Cord blood is collected according to ethical, scientific, and legal standards, after getting the consent of mother. Then, it is sent to the cord blood bank at IBTO headquarters. In cord blood bank, several tests are performed including determination of number and identity of the stem cells within the sample, as well as testing for viral and bacterial diseases in mother and cord blood.
The process leads to separation of the nucleated cells and determination of HLA type is. The HLA type is registered in the HLA registry. The stem cells are mixed with appropriate preservatives and then stored in nitrogen tanks at -190 °C.
The national cord blood bank stores stem cells and offers them to any patient in need; They are not stored for private purposes. Once, a physician makes a request, a HLA-matched cord blood is selected and forwarded to the transplant center.
The center is expected to join with other cord blood banks around the world to build a strong network and inventory of high-quality cord blood units available for any patient who needs a transplant.
Cord Blood Bank
- IBTO in collaboration with WHO-EMRO to prepare 15-year regional status report for blood safety and availability in EMR
- The Governing Council Meeting of Asian Association of Transfusion Medicine in Tehran
- International workshop on Strengthening Leadership and Governance of National Blood Services
- The 4th Iran International Congress of Transfusion Medicine hosts 18 countries
- The first blood bag manufacturing company opens in Iran
- IBTO Managing Director presents Iran's experience in thalassemia prevention at 35th International Congress of the ISBT
- Message from Dr. Ahmed Al-Mandhari Regional Director of EMRO on the occasion of World Blood Donor Day
- Rwanda National Blood Service: A role model for least developed countries
- Visit of Pharmaceutical & Medical equipment delegation from Oman to IBTO
- AB negative: The rarest blood type in Iran

domain: health


Germany changed course this weekend over which type of smartphone technology it wanted to use to trace coronavirus infections, backing an approach supported by Apple and Google along with a growing number of other European countries, according to Reuters. However, Britain’s National Health Service (NHS) will utilize its own centralized contract-tracing system, rather than deploying the exposure notification technology being developed by the tech giants.
Germany’s Chancellery Minister Helge Braun and Health Minister Jens Spahn said in a joint statement that Berlin would adopt a “decentralized” approach to digital contact tracing, thus abandoning a home-grown alternative that would have given health authorities central control over tracing data. As recently as Friday, Germany backed a centralized standard called Pan-European Privacy-Preserving Proximity Tracing (PEPP-PT), which would have needed Apple in particular to change the settings on its iPhones. When the tech giant refused to budge there was no alternative but to change course, a senior government source told Reuters.
Meanwhile, UK’s coronavirus contact-tracing app is set to use a different model to the one proposed by Apple and Google, despite concerns raised about privacy and performance, reports the BBC News. The NHS says it has a way to make the software work “sufficiently well” on iPhones without users having to keep it active and on-screen.
On April 10, Apple and Google announced a joint effort to help governments and health agencies reduce the spread of COVID-19. They’ll launch a solution that includes APIs and operating system-level technology to assist in enabling contact tracing. Given the urgent need, the plan is to implement this solution in two steps while maintaining strong protections around user privacy.
First, in May, both companies will release application programming interfaces [APIs] that enable interoperability between Android and iOS devices using apps from public health authorities. These official apps will be available for users to download via their respective app stores. Second, in the coming months, Apple and Google will work to enable a broader Bluetooth-based contact tracing platform by building this functionality into the underlying platforms.


It's always easier to share the celebratory moments of our lives than the challenging ones, especially on social media. But that doesn't mean those difficult moments don't happen, and as Shay Mitchell wrote on Instagram recently, those moments can bring us together too.
Mitchell revealed that she experienced a miscarriage in the past year. Because she decided not to talk about it publicly until now, it led her to reflect on how little we really know about what others are going through at any given time.
"We all have to deal with various struggles and challenges in life," Mitchell began her post.
"And sometimes it's easier to only showcase the good times on social media, which is what leads many people to criticize it for its lack of authenticity," she said.
"Having so many people follow me on Instagram and read my posts is both incredibly humbling and hugely uplifting. The support and affection that so many of you show me lifts me up during even my darkest days, one of which happened last year after I miscarried and lost the child of my hopes and dreams," she explained.
"In the spirit of the new year, I think that we need to remember that we are all on this journey together—in good times and in bad—and to remind ourselves that we seldom really know or understand the struggles and hardships that other people are going through," she wrote. "So, for 2019, let's all try to be a little more compassionate, empathetic, patient, and thoughtful with each other."
Although miscarriages are relatively common, we don't usually hear about them.
Pregnancy loss is usually accompanied by complex, difficult feelings of guilt or shame, so it's understandable that many people would prefer to keep them private. But for some, the stigma associated with miscarriage discourages them from sharing what they're going through, making them feel isolated while finding their way through an already challenging situation.
The stigma and the silence around miscarriages also makes them seem less common than they are. In reality, an estimated 10 percent of known pregnancies end in miscarriage, which is defined as pregnancy loss that occurs within the first 13 weeks, according to the American College of Gynecologists and Obstetricians (ACOG).
So, although the decision to be open about pregnancy loss is obviously a very personal one, talking about that experience can help you and others feel less alone. Ultimately, as Mitchell wrote, the most important thing is to remember that we can't assume that we know what others are dealing with. And whether or not they come forward with details like these, we should treat them with compassion and empathy.


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[button-green url=”#” target=”_self” position=”center”]Download Hongkong at night wallpaper full HD[/button-green]
A corner of the city of Hong Kong at night.. beautiful, brilliant,.. This is wallpaper describing activities at night in a corner of Hong Kong. Operation of ships, boats, large and small harbor .. .. biggest cable-stayed bridge crossing the river. The skyscrapers and lights.


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Treasure? You want some treasure? I'll you how to get treasure. And you don't need to wait around for some ratty, old, pirate map with a big red X on it to fall into your possession either. You don't need a pirate ship to get to it or a shovel to dig it up. Ah, I see you are interested. Put on this dress and wait for the darkness of night to fall. Make your way to your nearest Halloween or Pirate Theme Party and you'll have all the treasure, loot, and booty you can handle. It may not be chests loaded with gold doubloons, but it'll bring a smile to any pirate soul. If you had your heart set on the gold doubloons, you'll have to wait around for the ratty, old pirate map.
Costume Includes hat with skull applique, lace up front peasant dress, and striped panty with applique. Stockings not included Use for a Costume Party or for play 88% nylon, 12% spandex Includes hat with skull applique, lace up front peasant dress and striped panty Great Halloween costume

domain: entertainment


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The design inspiration for this caramel brown leather dog collar came from a global community of visionary friends and rock n’ roll fashion. We wanted to create a beautiful leather dog collar that was soft, luxurious and exciting in style. And that’s exactly what we did.
Like the rest of Puppy Panache’s offerings, our SUPERSTAR collars are handmade by skilled Italian artisans, committed to their craft and using techniques dating back to the Roman Empire.
Only the softest, finest Italian leather is used. Over 40 manual steps are taken to provide the collars with maximum comfort, strength and durability. The collars are then adorned with square princess-cut gold pyramids and small round silver studs. All the metal hardware used is brass and zinc alloy-based, which translates into rust-resistant, nickel and lead-free durability.
Like your designer handbags, you and your pup will be proud to show off this stunning caramel brown leather dog collar. So why not have a little rock ‘n roll for your pup too?
Matching leashes and double wrap bracelets are also available. Or – buy this collar and leash set and save 10%!
Additionally, we can also make this design in other custom colors – contact us for more details! (lead time is 6 – 8 weeks)
Enjoy FREE SHIPPING on all orders!
This is one of our favourite collars for our little pup. The leather is nice and soft and durable. We love love the colour and design. It’s a timeless piece. It comes with a cute dust bag too!
Karen Lawton –
Thank you Bao.
Your pictures of you in your Collar, highlight the features very well.
If you’d like to follow Bao on his adventures, go to your IG & follow @baothechi

domain: design


Combi Boilers - Efficient Hot Water and Space Heating | A
Find the best Home Water Delivery near you on Yelp - see all Home Water Delivery open now. Explore other popular Local Services near you from over 7 million businesses with over 142 million reviews and opinions from Yelpers.
Boiler Water Treatment Even when feedwater chemistry is controlled within ASME, IAPWS, or EPRI guidelines, internal boiler treatment is still necessary to control deposition and corrosion in the high-temperature environment of the steam generator. Preventing excess carryover of impurities to the steam system is also critical.
The boiler can also be used in hot-water systems. The boiler can be fully assembled and tested at HKB boiler solution before taking delivery. This makes it unnecessary to assemble the boiler on-site, significantly shortening the total installation time. To achieve better efficiency, an economiser can be
Our bottled water delivery service turns to-dos into ta-dahs! Your local Culligan Water Expert delivers your choice of bottled water direct to you. No more grocery runs, loading or lugging bulky containers. We do the work. You take care of business.
When a hot water tap is opened, incoming water flows through the heat exchanger. Heated boiler water, supplied from the fire tube heat exchanger, prioritizes heating the domestic water to the desired temperature. When space heating is needed, a diverter valve directs the heated boiler water into the external space heating loop.
Prestige 9.9 GPM Propane Liquid High Efficiency Combi Boiler with 199000 BTU Rheem's Prestige High Efficiency Liquid Propane Rheem's Prestige High Efficiency Liquid Propane Combi Boiler provides an efficient, continuous supply of domestic hot water used for faucets, showers, washing machines, etc.) and provides hydronic space heating for residential applications such radiant floors, baseboards
Sep 18, 2020 · A water-tube boiler is one in which the fluid to be heated passes through a series of pipes or tubes and the combustion gases are external to the tubes. Heat from the combustion gases passes through the metallic tube walls. Large water-tube boilers are constructed with ferrous materials.
Nov 02, 2016 · of boiler water can allow for better operation by providing more consistent control of boiler water chemistry and chemical additives. Chemicals are added to boiler water to control scale and corrosion and provide a good quality steam. While most boiler water additives are non-toxic, every additive needs to be reviewed and approved. A list of
A hot water dispenser is great for use in your kitchen, cafeteria, buffet, or office break room and provides hot water for any cooking or brewing applications. Choose from an adjustable or fixed temperature commercial hot water dispenser and from a variety of capacities
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Aim high with Navien High efficiency, High output, High performance, all in one compact combi Navien new NFC-H and NCB-H are the ultimate high efficiency condensing combination boilers with the capacities to supply both heat and domestic hot water for larger homes enough space heat for a whole house, plus hot water to run up to 3 showers and a dishwasher
ProLine ® XE Combi Boiler. The first-ever residential combination boiler from A. O. Smith comes with an industry-leading 4.8 gal/min domestic hot water delivery and 95% AFUE, as well as a superior space heating performance with up to 74% more heating capacity than other combination boilers.
The boiler receives the feed water, which consists of varying proportion of recovered condensed water (return water) and fresh water, which has been purified in varying degrees (make up water). The make-up water is usually natural water either in its raw state, or treated by some process before use.
Bulk Water Delivery in Port Angeles, WA. About Search Results. About Search Results. YP - The Real Yellow Pages SM - helps you find the right local businesses to meet your specific needs. Search results are sorted by a combination of factors to give you a set of choices in response to your search criteria. These factors are similar to those you
The boiler receives the feed water, which consists of varying proportion of recovered condensed water (return water) and fresh water, which has been purified in varying degrees (make up water).The make-up water is usually natural water either in its raw state, or treated by some process before use.
Find Boiler drain valve water delivery valves at Lowe's today. Shop water delivery valves and a variety of plumbing products online at Lowes.com.
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Mar 14, 2021 · Recurring Water Delivery Service, Every 2 Weeks, 2 units of 5 Gallon Bottles - Fulfilled By PWNA Verified Purchase . The water bottles were left outside the main building door at the bottom of the stairs. There is an elevator around the side of the building that is


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Sand Sledding Anyone?
Great Sand Dunes National Park, CO
It doesn’t need to be below freezing temperatures for you to sled or board in Colorado’s nationally preserved dunes. With ridges up to 750ft high, a quick walk from the main parking center and any non-vegetated slope is fair game.
Companies rent junior and adult-sized sand sleds starting at about $18-$20 per day from April through October.
To add some more insight to your visit, we recommend the free sunset tours with park rangers included, which also include discussions about the ecosystem of the dunes and let you stargaze through a telescope if the nights are clear.


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The Adventures of Huckleberry Finn
|Series title:||Classic Novels Ser.|
|Publication Date:||Sep 1999|
| Publisher:||Barron's Educational Series, Incorporated|
| Book Format:||Paperback|
|List Price:||USD $8.95|
| Book Description: |
Books in the Classic Novels series are unabridged editions of literary masterworks. However, they are much more.


- What is the range of a 9mm pistol?
- What is the best distance to shoot a 9mm?
- Will a 9mm kill a bear?
- At what distance do most gunfights occur?
- Will 9mm stop an attacker?
- What caliber can kill a bear?
- What sidearm does Secret Service carry?
- Will a 9mm kill a mountain lion?
- Can a bullet reach space?
- Can a 9mm penetrate a human skull?
- How far can a bullet travel horizontally?
- Will a 9mm go through a person?
- Can a 9mm kill a lion?
- How far can a 556 bullet travel?
- How much does a 30.06 drop at 400 yards?
- What distance should I Zero 9mm?
- What handgun does the Navy SEALs use?
What is the range of a 9mm pistol?
Pistol Auto 9mm 1AMuzzle velocity396.23 m/s (1,300.0 ft/s)Effective firing range50 m (55 yd)Feed system13-round detachable box magazineSightsIron sights18 more rows.
What is the best distance to shoot a 9mm?
The first distance is six to 10 feet. Six feet is about as close as you can get to a hanging paper target without the muzzle blast from normal self-defense rounds moving the paper too much. Six to 10 feet is close enough that any gun/ammo combination can shoot 1” or better groups.
Will a 9mm kill a bear?
He used a 9 mm semiautomatic pistol. Lewis said such a low-caliber gun ordinarily doesn’t pack enough punch to kill a bear. But Brenner loaded the pistol with full-metal-jacket bullets that penetrated to the bear’s vital organs, he said.
At what distance do most gunfights occur?
approximately three to five yardsAccording to my friend, mentor, and master defensive firearms instructor Tom Givens, most gunfights involving civilians and felons takes place at a distance of approximately three to five yards, approximately three and one-half rounds are fired, and no further shooting takes place after approximately three seconds.
Will 9mm stop an attacker?
No handgun round is sufficiently powerful. In that regard the 9mm loses very little on a shot for shot basis with the heavier calibers. When you factor in reduced shot to shot recovery time and a greater number of available rounds (for the same size magazine) the 9mm is often a superior choice, and rightly so.
What caliber can kill a bear?
While some folks claim the .44 Magnum is the minimum for charging bears, many others have opted for a Glock 20 in 10mm Auto and, interestingly enough, passed right by the .357 S&W Magnum. Several folks have even successfully killed bears with a 9mm.
What sidearm does Secret Service carry?
The U.S. Secret Service has officially adopted Glock as its new duty pistol. Since 1998, the Secret Service has armed its agents with a duty carry SIG Sauer P229 pistol in . 357 SIG.
Will a 9mm kill a mountain lion?
Yes, a 9mm will absolutely kill most animals in North America with a well placed head shot. Michael Becker, I’ve owned and fired rifles, shotguns, and handguns. Excellent shot. My money would be on the lion.
Can a bullet reach space?
No. There is not sufficient muzzle velocity for a bullet fired from any civilian or military firearm to reach space (escape velocity). This is an extremely dangerous practice and you are risking harm to other people.
Can a 9mm penetrate a human skull?
The 9mm is exceptional at penetration. It can penetrate the skull at long ranges. A hollowpoint will open up only by traveling through flesh. Hard objects like a skull will not expand the bullet.
How far can a bullet travel horizontally?
According to the National Rifle Association, if you’re going for distance, the optimal angle of elevation is around 30 degrees from horizontal. The NRA says that for a 9 mm handgun, the most popular handgun according to Guns.com, a bullet will travel up to 2,130 yards, or about 1.2 miles.
Will a 9mm go through a person?
It depends at what angle the round hit the body. But at close range, there is a high chance of over-penetration that is it will go through the human body even if the shooter had a pocket sized 9mm chambered with badly manufactured Hollow Point rounds.
Can a 9mm kill a lion?
35 Whelen or 9mm Mauser (also a 9mm size bullets, but much heavier and with much more power behind them) would kill a lion with most shots to the vital area or head.
How far can a 556 bullet travel?
TL;DR: 850 yards for . 223 Rem, 900 yards for 5.56 NATO. First, some pedantic nit-picking about notation: The SAAMI standard designation for the commercial cartridge is “223 Remington”, usually written in caliber notation (fractional inches) as “.
How much does a 30.06 drop at 400 yards?
How much does a 150 grain 30 06 bullet drop at 300 yards?Range (yards)Drop (inches)Velocity300-13.38372218350-20.82092128400-30.17832041450-41.62441955Jun 13, 2020
What distance should I Zero 9mm?
Most handguns, including 9mm and other defensive-grade calibers, will do well sighted at about 25 yards. You might possibly wish to sight something like a . 22LR at a shorter distance, and hunting revolvers in heavy calibers should probably be sighted in at least at 50 if not 100 yards.
What handgun does the Navy SEALs use?
The Navy’s special operators are preparing to part with the Sig Sauer P228 and adopt the Glock 19 as their sidearm. While SEALs have long carried the P226, the more compact P228 has been a staple among Naval Special Warfare Combatant Craft crew.


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Free shipping for orders over €80 / $100 with the code FREESHIP at checkout
We would like to encourage our customers and visitors to be conscious about their consumer choices and the ethical and ecological impact of their decisions.
5% of our profits will be used to support different projects around the world with the intention to improve the planet and the life that resides on it. As the business grows, so will our percentage and our contributions to these organizations.
Tree planting is a very important part of balancing out our carbon footprints. Deforestation is happening so rapidly around the world, and there is a dire need for more trees. They are after all the lungs of the Earth! We encourage you to plants trees in your locality as much as possible, and also look into organizations that are working tirelessly to do this. Here are a couple of great organizations worth supporting:
Support and Protect Indigenous Communities and Tribes
In this ever changing age of technology, we can sometimes forget about our planet's indigenous and tribal people, who still live very much connected to the land. Consumer demand is having a severe impact on tribal people worldwide, driving them away from their rightful land and home, spreading disease, and forcing cultural change. We encourage indigenous rights to keep the flame of wisdom alive on our planet. Here are a couple of organizations worth looking into:
Sustainability and Water
Water is the life blood of the earth, and a basic human right, yet so many do not have access to this basic survival need. Without clean water, we have nothing.
Although the world is changing rapidly regarding women's rights, we still have a long way to go. So many women around the world are suffering violence, abuse and poverty. Check out the Women's Foundation Nepal to support women's empowerment:
Ramana's Garden is a very special orphanage in Rishikesh, India that offers a beautiful home and school for orphans with an organic veggie garden:
Embracing The World is working on several amazing projects to help alleviate poverty and suffering around the world. They work on disaster relief, building homes, healthcare, orphanages, education and more:
© 2023 Ekeko Crafts.

domain: sociology


A vegetation fire broke out on the fourth of July in Paso Robles at nine in the evening.
Units arrived to approximately a quarter acre fire burning in the open space between the neighborhood along Kleck road and highway 46, according to a press release.
The fire was fully controlled a little more than half an acre by 11 in the morning. The report goes on to say eyewitnesses reported illegal fireworks being launched in the area prior to the fire.
The Paso police department have an ongoing investigation for those responsible.


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Root Canal (Endodontics)
What is Root Canal Treatment?
Within the hard surface of the teeth lies a soft tissue called the pulp. This pulp contains vital parts like the nerves and connective tissue necessary for the health of the teeth. When the pulp becomes infected or inflamed, dentists undertake a root canal treatment. This process involves detaching the nerve of the tooth, thereby saving the tooth and removing pain.
Sometimes the treated tooth may need re-treatment. This usually happens when the previous infection was not cleaned or sealed properly, or when the filling is broken causing reinfection.

domain: medical


What the flock is the Flamingle?
The Flamingle is a weekly newsletter created just for UW–Madison alumni. It’s quick, fun, and easy to read, making it the best way to reconnect you to campus. Each Friday, we curate and share a handful of the week’s top stories about campus and the surrounding community — from the quirky to the academic and everything in between. You’ll also get the latest installment of our column “Ask Flamingle HQ,” which takes a look into campus quirks, traditions, and history. In short, the Flamingle lets you revel in everything you love about the UW.
So, why the Flamingle? Excellent question! On the morning of September 4, 1979, students trudging up Bascom Hill to their morning classes wiped the sleep from their eyes to see the entire hill turned pink. The Pail & Shovel Party, led by legendary jokesters James Mallon ’79 and Leon Varjian x’83, “planted” 1,008 plastic pink flamingos on the Bascom lawn as a victory stunt after winning the student government elections. The flamingo stunt did more than give UW–Madison a reputation of “inspired goofiness.” It also solidified the bird as a campus and Madison icon: in 2009, the plastic pink flamingo became the official city bird.
Here at the Wisconsin Alumni Association® (WAA), we believe in helping all alumni stay tapped into the inspired goofiness of UW–Madison. So come on. Flamingle with us.
Have a question, comment, or anything else you’d like to share with Flamingle HQ? Send us a message!
Think you should be receiving the Flamingle and aren’t? Be sure to check your email’s spam and “promotions” filters, first. If we’re trapped in there, simply add us to your contacts list.
To make sure we have your current email address or to subscribe, please complete the following form.
When did the APIDA Student Center open?See Abe's Answer >
Why is the UW’s new global health major housed in the Department of Entomology?See Abe's Answer >
I’ve heard about something called the Raimey-Noland Campaign. Who was Raimey-Noland?See Abe's Answer >
Can you tell what decade these photos are from?Read More >
Which classic UW prank are you?Read More >
What is Day of the Badger, and how do people traditionally celebrate?See Abe's Answer >
How well do you know Bucky's relatives?Read More >
How Well do You Know the Alumnae in Alumni Park?Read More >
When was the Daily Cardinal founded?See Abe's Answer >
Only a true news buff can tell fact from fiction in these headlines.Read More >


*Material Description: Turkey 100% OCS Organic Certified Organic Cotton*
*<Photo Cooperative Awakening Series>
Before waking up every day, before lying down every day.
In the third batch of products, the photocooperative hopes to bring awakening primers to think about the new day; it is also a day of memories.
Day by day, we are constantly repeating the same cycle in our lives?
Still with a clear heart, not bound by the external framework?
The awakening series of the photocooperatives wants to awaken our sleeping souls. Every day, we face our own life with a new soul. We are not framed by inner fears, and we can live a more comfortable and full of every possibility.....
Turkish organic cotton, which has not been used for pesticides and herbicides for three years, was introduced to Taiwan by a well-known old factory, Taiyuan, weaving fabrics, and commissioned by the special manufacturing of the high-grade bedding group to work finely. The processing factory with 24 years of manual experience finely sewed. Made. *
* The light cooperation agency's mind is to let the Taiwanese people in the plastics industry big country use the organic cotton material that allows the skin to be completely breathable every inch of the pores during the eight hours of sleep every day, so that people who are already familiar with fast fashion will pick up again. Knowledge and hobbies about natural fibers.
As a brand with adult natural fiber bedding as the main axis, we hope to bring more awareness and reminder to our own products. It also makes the sleeping life and delicate skin more close to the natural one. desire. *
In the crowded, colorful streets of the East, from Korean and Japanese fashion shops to internationally renowned brands, fashionable clothing changes every season, and people who embrace fast fashion know nothing about the fabrics of their daily skin. .
Unconsciously, we can't identify the fabric on the body is actually a poorly-cored petrochemical fiber.
Unconsciously, we can't feel it. Although we didn't eat the fabric, we lost a lot of printing dyes and chemicals. Forgetting our body actually needs ventilation and breathing. Will it be in the distance between raw materials and consumers? On the day we don’t know each other, we have forgotten that the earth and the earth breathe....
Because bedding is not a daily change of clothing, so more attention to whether its materials and processes are friendly to the human body, we try to do a little more, the environment, the supply chain, the transparency of product information, the creation of a brand The starting point and each of these choices should start with goodness.
**"Photo Cooperative" is a bedding brand that combines beauty, temperature and friendliness.**
**The dual personality of FiatLux Light Cooperative.**
External personality is derived from the sense of responsibility for social care, so we are committed to promoting the use of natural fibers (such as cotton, hemp, wood pulp fiber, Tencel, etc.) or recycled fiber. The inner personality is visualized from the beauty, designed to set off the texture of the fabric itself, the style is simple and elegant, let people return to the bedroom and release the pressure and tension throughout the day in the gentle color system.
**"Photos cooperatives don't just sell bedding, they just don't just sleep. What we are responding to is the desire to really... quietly after each return to the bedroom."**
** "Photo Cooperative" is the first organic cotton bedding brand in Taiwan that offers a variety of colors.
It is also the first bedding brand in Taiwan with the core of natural fiber and environmental friendliness. **
Origin / manufacturing methods
Turkish organic cotton / Taiwan textile factory Taiyuan manufacturing / 30 years of power processing factory sewing


text: As you might know, Goldman Suchs announced if paying through ApplePay I can get 3% cash back, unfortunately today at 2 locations card reader did not work. Meaning, bank providing false information. It's ok, providing to the cashier physical card I will still get 1% cash back, but I guess this is not right. What if I was buying something expensive at t-mobile, the difference would be more between 1% and 3%. I think it should be fixed.

domain: economics


Main Article Content
The government through the Ministry of Marine and Fisheries offers assistance of fishing vessel to achieve fisheries production targets. This procurement plan must be supported by the ability and selection of the right shipyard. Beacuse the information of the capability and capacity of fiber shipyards in Indonesia is unclear, so the realization of the procurement of fishing vessel in previous years did not met the planned targets. The purpose of this study was to analyze shipyard capacity to meet the planned procurement of KKP fishing vessels grant in 2019. First classification of fishing vessels is based on the size of each GT, which is <5 GT (type 1), 5-10 GT (type 2), and 20-30 GT (type 3). The second is the minimum shipyard criteria for building fishing boats. Third, an assessment of the shipyard is based on the criteria that have been made. Fourth, shipyard selection was carried out on each WPPN-RI using the load score method. The fifth calculates the number of ships that can be built by the shipyard. The results of the shipyard assessment found that 43% of shipyards have the ability to build type 1 vessels, around 38% of shipyards have the ability to build type 2 vessels, and around 19% of shipyards have the ability to build type 3 vessels. is 1625 units / period. Referring to shipyard capacity, it can be said that the entire shipyard is able to fulfill the plan to procure assistance for KKP fishing vessels in the 2019 budget year.


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NOTICE OF PUBLIC HEARING
PLEASE TAKE NOTICE that a public hearing will be held by the Board of Trustees of the Village of Rhinebeck on Monday April 29th, at 7:00 p.m., at the Village Hall, 76 E. Market Street, Rhinebeck, NY 12572. This meeting will be for the purpose of discussing the proposed budget for fiscal year 2013-2014 with the public. PLEASE TAKE FURTHER NOTICE that copies of the proposed budget are available for review at the office of the Village Clerk, 76 E. Market Street, Rhinebeck, New York on April 24th during regular business hours and at the public hearing. All interested persons will be given an opportunity to be heard in person or by directing commentsin writing to the Village Board of Trustees. The Village Board may choose to conduct other business at this meeting. By order of the Village Board of Trustees of the Village of Rhinebeck dated April 19, 2013.
COMMUNITY NEWS – INFORMATIONAL NOTICE
The Village of Rhinebeck has an opening on the Village Zoning Board of Appeals Board and is looking for a resident of the Village that is interested in serving on this board. The Zoning Board of Appeals meets the third Thursday of each month as needed and deals with zoning variances and interpretations of the zoning code. Please send your letter of interest to the attention of Mayor James Reardon, 76 East Market St., Rhinebeck NY 12572 or fax (845) 876-5453 or e-mail firstname.lastname@example.org
Planning and Zoning Clerk
Village of Rhinebeck


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The National Institutes of Health has awarded CareBand Inc. Phase I Small Business Innovation Research funding to determine whether the CareBand system can detect agitation in people living with Alzheimer’s disease and related dementias.
Agitated individuals are more likely to be prescribed high-risk psychotropic medications and are at greater risk for injury to themselves and others, which can lead to removal from home or care facilities. Measuring and ultimately predicting agitation can de-escalate stressful situations and is anticipated to decrease costs and caregiver burden, CareBand reports.
In Phase I of the NIH-supported study, CareBand Inc. which has developed a LoRa-based wearable that provides an individual’s near real-time indoor and outdoor precise location, movement and activity data, will deploy the technology to residents living in Bethany Village, an Indianapolis skilled nursing facility managed by American Senior Communities. Over a six-week period, facility staff will record observation-based, validated agitation scale data daily. The relationship between the motion data and the agitation scale data will then be evaluated and analyzed to expand existing CareBand capabilities to recognize and predict agitation.
The company is collaborating with the Regenstrief Institute,Indiana University School ofMedicine and several clinician-scientists with collaboration with Canada’s KITE-TorontoRehabilitation Institute.


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Return of the Jet Eye
For Illustration Friday - Return.
And I don't want anyone to think that I just drew an eye to make this silly joke just for IF.
I have been drawing eyes for silly jokes for some time now.
So there.aircraft eyes movies scifi and fantasy


text: Primary adrenocortical insufficiency (Addison's disease) is a potentially fatal condition that often develops insidiously and can be easily overlooked. Although rare in the general population, it is more common in patients with type 1 diabetes mellitus (T1DM). The combination of Addison's disease with T1DM and/or autoimmune thyroid disease is known as autoimmune polyendocrine syndrome type-2 (APS-2). T1DM commonly precedes the development of adrenocortical insufficiency in most patients with APS-2. We, in this study, present four cases of Addison's disease developing in adolescents with pre-existing T1DM. Risk factors for Addison's disease in this population include a history of other organ-specific autoimmunity, particularly thyroid, and a positive family history. In addition to the 'classic' Addisonian features, the development of unexplained recurrent hypoglycemia, reduction in total insulin requirement, improvement in glycemic control, or abnormal pigmentation should arouse suspicion of adrenocortical insufficiency. Adrenal antibodies have been proposed as a screening tool for Addison's disease in the T1DM population, but doubts remain about their specificity and sensitivity. The addition of specific HLA DRB1 subtyping has been proposed to improve predictive value.


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Of all the things which wisdom provides to make life entirely happy, much the greatest is the possession of friendship. Epicurus, Philosopher
I’m very fortunate to have good friends. Being an only child, friends become “sisters” to me and I cherish them. Unlike children, grandchildren, and other relatives, friends choose one another. I’m not sure what Epicurus had in mind when he spoke of wisdom and friendship, but I do know that a wise woman seeks friends with whom she can be truly herself, women (and men) who share her joys and sorrows, who help her to become a better person, who make her heart sing.
If your life is confined to your work and immediate family or husband and grandchildren, cat or dog, I encourage you to find a friend. Friends take time, energy, and cultivation (just like a beautiful garden) but, believe me, they will enhance your life for the rest of your life.
Affirmation: I seek out and have good friends.
Coaching questions: What do friends mean to you? If you are missing one or more really good friends, what steps can you take to attract friends into your life?
Coaching request: Tell a friend how much she means to you.


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A missing student of the Aligarh Muslim University, Ashraf Ali was found in Delhi on Wednesday.
According to the police, he went missing on 24 February and was found on 10 March in Delhi’s Jama Masjid area.
SSP Aligarh, Kuldeep Gunawat, in a video said that the AMU proctor informed the police about his location.
@sspaligarh श्री मुनिराज जी. के निर्देशन व #SP_CITY @kuldeep_gunawat के नेतृत्व में गठित टीमों के अथक प्रयास से गुमशुदा ए0एम0यू0 छात्र मौ0 अशरफ अली को सकुशल बरामद कर परिजनों को किया सुपुर्द । बरामदगी के सम्बन्ध में @sspaligarh द्वारा दी गई बाइट ।@Uppolice @dgpup @adgzoneagra pic.twitter.com/bem9BOispk— ALIGARH POLICE (@aligarhpolice) March 11, 2021
“He is suffering from depression and is getting medical help for the same,” the SSP said.
“Ashraf had been roaming on the streets of Delhi as he’s suffering from depression, ” the official added.
Earlier, protests were held in the Aligarh Muslim University, demanding action in the matter.
Member of Parliament, Assadudin Owaisi had urged the UP police to take “proactive steps to find Ashraf without further delay”.

domain: news


I’m publishing this Weblog to deepen perspectives on topics that light me up. These relate to my business interests...business communication, disruptive technologies and photography.
My work is changing so fast that I can barely grasp it all, much less fully comprehend the implications. Perhaps keeping this blog will help.
No longer are upwardly mobile people fleeing the cities; they're now fleeing from the suburbs back to the cities. And the cities' poor are moving to the suburbs. Moreover, the cities are becoming vital economic growth centers. Density, diversity and innovation go together and the population-dense cities have become talent magnets.
By 2011, America's major cities were growing faster than the suburbs for the first time since Americans began driving. These are just a few of the revealing facts about America's profound demographic changes and their implications. All from a fascinating article by Richard Florida here.
Sitting through Apple's big product roll-out yesterday I had a lot of thoughts beyond what Apple was announcing. One thought was "two industries as I knew them are now marginalized and dying."
A brilliant posting by Thom Hogan here.
I'm stepping back into this blog after a long break. Initially, I intended the blog to focus on disruptive technological change, an interest acquired while participating in the personal computer and desktop publishing revolutions. However, I was quickly overwhelmed. I discovered much more rapid change than I could digest. Probably most of us are both fascinated and overwhelmed by how the world is rapidly changing.
So I'm stepping back into this blog more gingerly. Just a personal journal on a few things I notice and think about. I hope like-minded people find it interesting.
Paris is one of the best places in the world for candid street photography, so I looked forward to doing a lot of it. But I haven't done much. Besides the natural reluctance to stick a camera in someone's face, it's too pleasant to just sit and watch the show. Still, much of the charm of Paris is the variety of its people, so one can't avoid taking random photos from time to time. And photos of people, even more than photos of architecture, tell you a lot about a place. Here are some people photos.
These last two are from Café de Deux Moulins, the setting for the film Amèlie.
We visited the Louvre yesterday, not to see the Mona Lisa, but to sit outside at Café Marly, which resides on a wing of the Louvre. It’s perfect for a leisurely lunch looking out over the Pyramid.
It’s mind-blowing to think about what I.M. Pei accomplished when asked to contribute a design. If one looked out over the area, sans pyramid, and considered what should be there, it seems the likely result would be something staid.
Pei thought way outside the box and his idea fits perfectly. Instead of creating a formal stuffy area, it seems a fun, democratic place to just hang out, as thousands do on breaks between exhibits. And, it's beautiful.
As night approaches, the area becomes even more interesting. Here one can just see the Eiffel Tower peaking out from the edge of one wing of the Louvre. We hadn’t noticed it until the lights started going on.
The smart photographers showed up with tripods to capture what will be crisp, beautiful photos. Me, I just shot handheld and even forgot that I could lower the aperture setting from f4 to f2.8. Grrrr. I must have lost my edge to that bottle of wine at Café Marly. Still, the beauty comes across.
"You can’t step into the same river twice” as the saying goes. That’s one reason I enjoy photography. It crystalizes a split second and lets you digest it before it has already vanished. And you can return to it again and again.
I once saw a book containing photos of Central Park in New York City that were shot from the same window every day. Each photo was different according the light, season and activity. Makes one realize that there are always interesting photos to be taken, wherever and whenever.
The following three photos were taken from a window in our hotel room in Paris. I’m sure there are several dozen more that would be different and interesting. Unfortunately we’ll be leaving in a few days.
While strolling through a neighborhood in the 7th Arrt., we looked down a small street and were amazed by the 3D illusion on the side of a building.
As we walked closer and examined it carefully, we turned to look at the adjacent building. It was a beautiful belle époque structure. The juxtaposition of the two was a visual feast.
We spent a long time considering the details of both buildings before we turned around to leave and were completely knocked out by the wonderful view of the Eiffel Tower behind us that we’d not yet noticed.
I’m counting on Gregory Pierce, my professional financial planner, to grow my wealth sufficiently that I can acquire one or both of these buildings.
I saw an amazing performance at Sacré Coeur. While leaning against a lamp post to steady my camera for a overview of Paris, a guy with a soccer ball climbed onto a gate post about six feet in front of me and began doing stretches. Then he reached down to an iPod Nano, selected some cool music, and began to perform with the ball, keeping it constantly in motion and never using his hands, only his feet, back and head.
He was in constant motion, even removing some clothing while the ball was also kept constantly in motion. It seemed impossible that he could sustain this for very long without dropping it, but he went on for several minutes.
His name is Iya Traoré; he's from Guiana and he has a Web site at:
I went to print something on my laser printer the other day. As I did so, I realized it had been at least a month since I'd printed anything. It may actually have been a couple of months. Why is this is shocking? Ten years ago, I went though a 10-ream CASE of laser paper every two weeks.
I like to think I'm on top of trends and I might do better than most. Even so, when forecasts eventually become reality, it can be shocking. They sneak up on you. I felt embarrassed that despite having been aware of the paperless trend for several years, it ultimately ambushed me.
Now, in what is a bell-weather event, Nicholas Callaway, publisher of some of the world's most beautiful and artistic coffee table and children's books is burning his ships. He's abandoning print and moving completely to electronic publishing. "I have bet the whole ranch on this," Callaway told Reuters. "This kind of juncture happens maybe once in a century."
An insightful article covering Callaway's defection and the new opportunities that e-books promise appears here. Or here.
The Internet is full of informative stuff. This, however is a must read. As Ann Marie Conception tweeted, "This is BEST article on the state of the industry I’ve read all year"


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Engineering logo design ideas: Engineering companies thrives on professionalism and fidelity. The best engineering companies in the world are respected for maintaining best industrial practices and deliver on promised quality, quantity and schedule.
Many of them even go to the extent of over delivering to put a ‘wao impression’ on their clientele as they grow their brand with time.
In those post, We will be showcasing to you 100 of the best engineering logo designs around from top engineering brands across the globe.
There are different types of engineering services ranging from civil engineering to mechanical engineering, aeronautical engineering, chemical engineering, computer engineering, petrochemical engineering and much more fields of engineering.
So when you set out to make your engineering logo design, it’s important to make sure the logos align well with your company’s objectives and mission.
It is a common practice by some logo designers to follow trends when designing logos, like the almost out of trend 3d logo designs.
Engineering sector is broad, dynamic yet complex, so with your logos you should help your business prospects understand what your engineering company stand for in terms of services or products offering.


Shondra is a vocal, acting & performance coach
for Individuals of all ages who are aspiring to be a professional or just learning for enjoyment. She also coaches group classes. Learn proper breathing, support, vocal placement, enunciation and production, voice over, emcee, studio and performance skills. She also teaches guitar. Skype sessions available.
For more info...
"Batrina" interviewed on AZ-TV Channel 7's "Sandy & Friends" Morning Show.
That's Alright With Me (Shondra Original) Emcee & Opener for 2014 Cottonwood Idol at the Old Town Center for the Arts.
Dev Ross script w/ Shondra's songs
(Click on purple links for info)
Saturday, April 28th - "Tom & Shondra's Music Extravaganza" touring show w/Steve Sandner. 7pm
Friday, May 4th - Good Morning Sedona Networking Breakfast Show7am Los Abrigados Ballroom.
Sunday, May 20th - Sedona Speakeasy Supper Club.
2pm & 5pm performances "Days of Wine & Murder" Wine Tasting Murder Mystery Show.
Opening for Larry Gatlin.
ONLY ONE performance left at the Blazin' M Ranch!
Sunday, April 29th
For Reservations Call: (928) 634.0334
Shondra Music © 2016


Dubai Hosts the World Vape Show for the Third Time: Uniting Vaping Enthusiasts from Around the Globe
The highly anticipated World Vape Show Dubai is returning, promising to be an unforgettable event for all. Following the success of four previous vape events held in Dubai, London, and Paraguay, this year's show is set to be bigger and better than ever before. Organizers are bringing together manufacturers, suppliers, and vaping professionals from around the world, making it an unmissable gathering for anyone passionate about the vaping industry.
The World Vape Show Dubai has become renowned for its ability to showcase thousands of beloved vape products. Once again, manufacturers and suppliers from across the globe will converge to exhibit their latest offerings, providing attendees with an exclusive look at the most cutting-edge vaping technology and accessories. Whether you're a retailer, distributor, wholesaler, or simply an enthusiastic vaper, this event is designed to cater to your interests.
From all over the world
With a diverse B2B audience from over 88 different countries, the World Vape Show Dubai serves as an unparalleled networking opportunity. Engage with e-cigarette leaders from around the world, forge valuable connections, and stay up-to-date on the latest industry trends. This is your chance to meet like-minded professionals, exchange knowledge, and explore potential collaborations that can shape the future of vaping.
The exponential growth of the e-cigarette market cannot be ignored. With a staggering 39 million users already embracing vaping in recent years, the industry is forecasted to exceed 64 million users by 2023. This disruptive innovation has garnered significant attention globally to combat smoking and curtail the online sale of unregulated devices. The rising popularity of vaping extends far beyond borders, with the UK, US, UAE, and various other countries embracing this trend.
Prepare to immerse yourself in the World Vape Show Dubai and witness the latest innovations that are revolutionizing the vaping industry. Discover new products, technologies, and services that are shaping the future of vaping. From state-of-the-art devices to an extensive range of e-liquids and accessories, you'll have the opportunity to explore and experience the very best that the vaping world has to offer.
FLAVORIQ will attend the event
We are thrilled to announce that FLAVORIQ, a leading innovator in the field of vape flavour development and manufacturing, will be participating in the highly anticipated World Vape Show 2023. Through their strategic partnership with Hertz Flavors, Europe's top supplier of tobacco industry flavours, FLAVORIQ has established itself as a trusted provider of flavour concentrates, liquids, CBD flavours, nicotine solutions, and flavour enhancers. Visitors to the World Vape Show will have the opportunity to explore FLAVORIQ's exceptional product range, meticulously crafted by their team of experienced flavorists. Please visit us at stand #6111 to see how FLAVORIQ sets new standards for taste, quality, and innovation.
How to attend?
To secure your spot at the World Vape Show Dubai, register for free online through the official website at https://worldvapeshow.com/dubai/visiting/tickets. Don't miss out on this incredible opportunity to be a part of a global vaping phenomenon and connect with industry leaders who are driving the industry forward.


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Recently I wrote about how now, more than ever, our stories are important. As a writer of American historical fiction and American historical fantasy, I know our history is full of amazing stories. Reading these stories enlarges our understanding of the human experience. It helps us make sense of the present.
“Understanding our history informs our understanding of how we move forward into our future.” (Emma D. Dryden)
Two of my favorite reads this year were Ron Chernow’s Alexander Hamilton (the inspiration for the Broadway play) and David McCullough’s John Adams. What better reads to learn about how politics work! No two men were more contrary in life and character than Adams and Hamilton.
“Facts are stubborn things; and whatever may be our wishes, our inclinations, or the dictates of our passions, they cannot alter the state of facts and evidence.” (Adams)
Adams grew up in a “tidy” New England village. He was born into a well-respected family who could trace their lineage to the first Pilgrims. He was well-educated with a passion for the law. He craved “Honour” and was zealous in his pursuit for independence. He had a keen sense of fairplay. In fact, he became the defense lawyer for the British soldiers who fired upon civilians in what became known as the Boston Massacre. He was diplomatic, although sometimes he could be thin-skinned when he perceived criticism. When this happened, he depended upon his wife, the incomparable Abigail Adams, for clarity. Their marriage remains one of the most enduring love stories in American history.
“It's not tyranny we desire; it's a just, limited, federal government.” (Hamilton)
Born on the island of Nevis in the Leeward Islands (of the Caribbean), Hamilton was the illegitimate son of a woman who, according to local island myth, was mulatto. He grew up in a “…a tropical hellhole of dissipated whites and fractious slaves…” The shame of his birth dogged him all of his life, but it also may have influenced his "enlightened" ideas about abolitionism. Orphaned at an early age, he was taken into the care of a wealthy merchant, and eventually sponsored to attend King’s College in New York City, where he too developed a passion for law. Although married and father to eight children, he enjoyed many affairs. He was brilliant, outspoken and ambitious. He was also arrogant with the confidence and temper to match. An aristocrat at heart, he had little patience for the "common man."
“There are seasons in every country when noise and impudence pass current for worth; and in popular commotions especially, the clamors of interested and factious men are often mistaken for patriotism.” (Hamilton)
Hamilton’s feud with Adams was the stuff of legend (as was his feud with Thomas Jefferson and, of course, with Aaron Burr. We remember how that one turned out, right?) When Adams was running for a second term as president, Hamilton published a pamphlet weeks before the election, titled “Letter…Concerning the Public Conduct and Character of John Adams.” For 45 pages, he lamented on Adams’ incompetency as president, passing it around to the electors, a system he helped create. (Does this sound familiar or what?) Adams didn’t win the election.
Adams and Hamilton had a complicated and contentious relationship. But it was the coming together of these two brilliant minds that created such a grand experiment.
“All communities divide themselves into the few and the many. The first are the rich and wellborn, the other the mass of the people…The people are turbulent and changing; they seldom judge or determine right. Give therefore to the first class a distinct, permanent share in the government. They will check the unsteadiness of the second, and as they cannot receive any advantage by a change, they therefore will ever maintain good government.” (Hamilton)
“Because power corrupts, society's demands for moral authority and character increase as the importance of the position increases.” (Adams)
What do you think?

domain: library


Adam Rudolph's music has always been exotic and yet familiar, far-flung, and seemingly nearby. Then again, the same can be said of Hamid Drake and Ralph M. Jones' work. This trio is sort of a dream team of performers. OK, just about every project Rudolph completes is a stellar combination created for a particular purpose. Presently, the Tibetan word for compassion, Karuna, is fitting. These dozen tracks radiate a kindness and humanity. The music is empathic for the listener because of the musicians' ability to understand and share in the musical consciousness of each other.
Rudolph and Drake's music relationship dates back nearly 50 years , and with Jones, 45 years. The two percussionists learned under first, Fred Anderson, then Don Cherry, before working with Yusef Lateef and Pharoah Sanders. Jones and Rudolph fused West African and American musics with Foday Musa Suso in the Mandingo Griot Society. The three have collaborated most recently in Adam Rudolph's Moving Pictures, and releasing Glare of the Tiger (Meta, 2017) with this inventive trio.
Of the twelve improvisations presented, only one, "Two In Three," clocks in (barely) over six minutes in length. That means each piece is complete and a succinct statement. Each is a discovery of a unique percussion instrument like udu drums, djembe, or gourds, and each presents a triangulation of sounds. "Watergoddess Blues" overlays Rudolph's hand drumming and flute with Drake's drum set and Jones' tenor saxophone. It, like all heard here, is simply infectious. The three maintain a continuous exchange of musical ideas, with the constant stabilizer of rhythm. Besides the Art Ensemble of Chicago, few have explored the rhythms of this world like Rudolph, Drake, and Jones. Pieces like "Ancient, Future, Now" can be located on a map, first Africa, then Australia, before the Amazon. It's all very exotic, yet familiarthe sounds of a shared humanity.
Watergoddess Blues; Myth Science; Etymologies; Visions of Beyond; Himma; Entropic Entities; Journeys; Water Voices;
Mosaics; Two in Three; Ancient, Future, Now; Cry of the Bamboo Flute.
Hamid Drake: drumset, udu drums, gourd drum, percussion; Ralph M. Jones: soprano saxophone, tenor saxophone,
hulusli, ney, bamboo flutes, sipsi, c and alto flutes, bass clarinet, spoken word; Adam Rudolph: handrumset (kongos,
djembe, tarija), electronic keyboards and samples, cajon, udu drums, thumb pianos, marimbula, sintir, mouth bow,
selya overtone flute, gongs, dusun'goni, percussion.
All About Jazz has been a pillar of jazz since 1995, championing it as an art form and, more importantly, supporting the musicians who create it. Our enduring commitment has made "AAJ" one of the most culturally important websites of its kind, read by hundreds of thousands of fans, musicians and industry figures every month.
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To expand our coverage even further and develop new means to foster jazz discovery and connectivity we need your help. You can become a sustaining member for a modest $20 and in return, we'll immediately hide those pesky ads plus provide access to future articles for a full year. This winning combination will vastly improve your AAJ experience and allow us to vigorously build on the pioneering work we first started in 1995. So enjoy an ad-free AAJ experience and help us remain a positive beacon for jazz by making a donation today.


text: On my way to the gym one night I noticed a carnival being set up right next to my gym. I’ve always wanted to photography a carnival and now was a better time than any. I’ve always love the carnival. The food, the games and especially the rides. Who could not have fun at a carnival?


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ORSP Small Grant Recipients Presented Their Research At Google
Professors Anoshua Chaudhuri (Economics), Yeon-Shim Lee (Social Work) and Grace Yoo (Asian American Studies) presented at Google on May 23, 2018 on their research, “Experiences Of Chinese, Filipino, Indian And Korean H1B Visa Workers In The United States: Caring For Family Abroad.” Chaudhuri, Lee and Yoo are recipients of a 2015 ORSP Collaborative Award.
Three early-career faculty members win prestigious NSF CAREER grant
Three San Francisco State University faculty members have been given the National Science Foundation’s (NSF’s) prestigious CAREER award this year: Assistant Professor of Computer Engineering Xiaorong Zhang and Assistant Professors of Biology Andrea Swei and Scott Roy. The five-year award supports early-career faculty who have the potential to be leaders in both research and education. San Francisco State leads the California State University system in these awards, with 17 winners since the program’s inception in 1996.
Jesus Ramirez-Valles, a public health leader, scholar, author and filmmaker, will join SF State as director of the Health Equity Institute (HEI) on Aug. 20. Ramirez-Valles has spent more than 20 years in academia leading educational programs, recruiting and mentoring faculty and doctoral students and, most recently, chairing the Department of Community Health Sciences at the University of Illinois-Chicago School of Public Health.
ORSP provides campus-wide access to the powerful and flexible funding research tool “Pivot.”
With a few easy steps, you can sign up for a Pivot account, link it to a pre-populated profile (or create a new one), and instantly find funding opportunities. For step-by-step instructions on getting started with pivot follow the steps here.


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Jihlava (Kraj Vysočina, Czech Republic)
|Source: Wikipedia Commons
Jihlava, (German: Iglau), is a city with a population of 50,000 in 2004, in Czech Republic in the area known historically as Moravia (coordinates: 49° 24′ 1″ N, 15° 35′ 26″ E). The Anabaptist movement early gained adherents here, but through the influence of Paul Speratus, Lutheranism predominated and Anabaptism was suppressed, with actions in 1529, 1536, and 1537. However, scattered individual Anabaptists continued to be found here and toward the end of the century increased in number. The city council then took special action to suppress them, and among others arrested their leader and preacher Hans Springer in 1592, and cruelly executed him.
Altrichter, A. "Zur Geschichte der Wiedertaufer in Iglau." Zeitschrift des deutschen Vereins für die Geschichte Mührens und Schlesiens (1928): 157 f.
Adapted by permission of Herald Press, Harrisonburg, Virginia, and Waterloo, Ontario, from Mennonite Encyclopedia, Vol. 4, p. 1096. All rights reserved. For information on ordering the encyclopedia visit the Herald Press website.
©1996-2013 by the Global Anabaptist Mennonite Encyclopedia Online. All rights reserved.
MLA style: Wiswedel, Wilhelm. "Jihlava (Kraj Vysočina, Czech Republic)." Global Anabaptist Mennonite Encyclopedia Online. 1959. Web. 22 May 2013. http://www.gameo.org/encyclopedia/contents/jihlava_kraj_vysocina_czech_republic.
APA style: Wiswedel, Wilhelm. (1959). Jihlava (Kraj Vysočina, Czech Republic). Global Anabaptist Mennonite Encyclopedia Online. Retrieved 22 May 2013, from http://www.gameo.org/encyclopedia/contents/jihlava_kraj_vysocina_czech_republic.


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Minot Police receive Back the Blue grant
A bill approved by the 2023 Legislature will provide the Minot Police Department with a grant to help address an officer shortage.
The department has received a Back the Blue grant of $102,194, which comes from funding approved by the Legislature to support recruitment and retention of sworn officers across the state. The Minot department plans to use the funds to offer bonuses to current officers who actively recruit a successful police officer candidate.
The bonus program is being developed to take effect with the first hiring session of 2024, Police Chief John Klug said.
The department currently is authorized for 84 sworn police officers and has nine vacant positions. On Jan. 1, the authorization increases to 85 officers, raising the anticipated vacancies to 10. However, Klug said, the department is holding a testing event this week for officer candidates and could fill some vacancies in mid-January based on those results.

domain: finance


The minute repeater was invented by Thomas Mudge in 1750. It uses a complicated, in-built striking system to indicate the exact time on request.
Following the determination of the time a small hammer strikes a timbre (miniature bell) to produce sound.
A low note is used to indicate the hours while a low note followed by a high one indicates the quarter hours, and minutes are indicated by high notes.
Using these notes the user is able to calculate the time up to the nearest minute