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The US on Tuesday sailed a warship close to a disputed South China Sea reef Beijing has built up into an artificial island, officials said, prompting China to express “dissatisfaction and opposition”.
Guided-missile destroyer USS William P. Lawrence navigated within 12 nautical miles of the Fiery Cross Reef, occupied by China and also claimed by Vietnam, Taiwan and the Philippines, the Pentagon said.
“This operation challenged attempts by China, Taiwan, and Vietnam to restrict navigation rights around the features they claim,” Pentagon spokesman Commander Bill Urban said in a statement.
“Because the Philippines’ maritime claims in relation to South China Sea features do not purport to restrict the exercise of navigation rights and freedoms under the law of the sea by the United States and others, they were not challenged during this operation,” he added.
It is Washington’s third “freedom of navigation” operation in the disputed waters launched in recent months after China built several artificial islands as it asserts claims to nearly all the sea.
Chinese foreign ministry spokesman Lu Kang confirmed the operation on Tuesday, saying the warship “illegally entered waters near the relevant reefs of China’s Nansha islands without the permission of the Chinese government”.
Nansha is China’s name for the Spratly Islands, where Fiery Cross Reef lies.
Authorities monitored the passage, Lu told a regular briefing.
“China hereby expresses dissatisfaction and opposition,” Lu said, adding: “I want to stress that the action taken by the US has threatened (the) security, interests and sovereignty of China.”
Beijing has significantly expanded Fiery Cross — which is around 1,000 kilometres (620 miles) from its island province of Hainan — since 2014, building a 3,000-metre (10,000 foot) runway there.
It landed an air force plane on the reef last month and last week sent military singer Song Zuying to serenade hundreds of troops and construction workers there.
China claims nearly all of the strategically vital sea, even waters close to Southeast Asian neighbours including Vietnam, the Philippines, Malaysia and Brunei who have competing claims.
Washington regularly accuses Beijing of militarising the South China Sea, saying it has built runways and deployed missiles to islands there.
Beijing denies the accusations and says US patrols have ramped up tensions.
The sail-by comes ahead of a ruling by an international tribunal on a case brought by the Philippines over the issue.
“These excessive maritime claims are inconsistent with international law as reflected in the Law of the Sea Convention in that they purport to restrict the navigation rights that the United States and all states are entitled to exercise,” Urban said.

domain: law


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← Back to manufacturers directory
Farmingdale, NY, USA
Nobu Hospitality, Bojangles and Mountain Mike’s Pizza are among those carving out respective development plans.
The Korean QSR chain has units in five states, but its newest Jacksonville, Fla. unit has one feature the others don't.
Tom O’Connor will strengthen relationships and drive growth in the Eastern region for Sammic.

domain: news


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As the State Legislature considers bills to raise the minimum wage and establish a minimum standard for paid sick days, we asked people across the state to answer a simple question:
What's one thing you’ve done to make ends meet that state politicians don't know anything about?
Here are some of the answers we received:
- Lynn, Poulsbo: "When my kids were younger, I remember going into the basement and garage to find unused outdoor light bulbs, taking them back to a hardware store, using the cash to buy food. $30. Now I'm on EBT.”
- GG, Orting: “I’m unable to buy new tires that are really needed now. I’ve cut down on every basic need, no going out. I can’t buy the food I need or get the eye and dental taken care of. You do without and hope you will still have a roof over your head.”
- Dawn, Bremerton: "I consistently run 2 months behind on my electric, gas, and water. I have never seen a utility bill that was not past due... except for the very first one. I shudder in fear every time I see a work truck for PSE or Cascade Gas in my neighborhood. My gas gets shut off about once per year and I am forced to open a brand new account while the other goes into collections.”
- Karen, Tacoma: “I listed my belongings for sale on OfferUp or craigslist.”
- Laurel, Seattle: "On Wednesdays of each week I can go to Fred Meyer to check for any almost out of date packages of meat they are selling for two or three dollars less than their original price. If I wait till Thursday afternoon to go, it will usually be marked down a little bit more. I don't chance doing this with hamburger, but I buy most of my other meat this way. This is just one of the things we do to help decrease expenses.”
- Jennifer, Auburn: “If I get sick I have to call in and say I'm sick within a certain amount of time before my shift, and if I miss more than one day then I'm fired. The other issue is being a mother. If my children are sick, I can’t call in sick to take care of them. By the third day I would be fired.”
- Nancy, Bellevue: "When I broke my wrist while doing company business, I had to keep working because I had no sick leave, etc. Because of that, I'm on my third cast because my wrist isn't healing — and I lost my job anyway.”
- Becky, Bellingham: “I stretch out my refills of my prescription medications to make them last longer — take less than I'm supposed to.”
- Bridgid, Seattle: “I went to college to become a professional landscaper. These days, I have to trade straight labor doing grounds maintenance because there isn't enough work to pay the rent (I'm lucky I had the foresight to buy my own tools, and that I have a landlord willing to do such a trade!), and in the winter I end up down to eating beans and rice to survive, like I have been for a month now. I won't go to the food bank except for in the most dire need because there are too many out there worse off than I am. Spring is coming, and then I'll have work again. I'm still strong, but I'm 53, and I don't know how much longer I can keep doing this.”
- Jane, Richland: “I don't turn on my furnace for weeks at a time”
- Angeline, Seattle: “I have been using food banks for over six years, now. I went three years without a car, and spent countless hours busing around the Puget Sound, sometimes spending enough time traveling to make one wonder if it was a benefit to actually work. I can attest to it being exhausting, demoralizing, and isolating. I simply could not do more than make it to and from work, get errands done — so, another thing I do to make ends meet is absent myself from functions including religious services and social functions.”
- Norman, Bremerton: "Many of us are working two jobs and trying to get an education at the same time. It will work if you are living with your parents. If your parents can't help, it is tough and many drop out of school perpetuating another generation living in poverty. Some of our politicians will argue they understand, because they were brought up poor. The reality is 16 hours a day, six days a week just for shelter and food, and then try to get ahead. It doesn't work."
- James, Seattle: “I reduced my food consumption to one meal a day.”
- JR, Orting: “I go without food choices I would like, turn the heat down, turn lights off, use less water, do not go to the doctor unless it is really need bad, walk when I can, drive with tires that need new ones, same with all car repairs, can not afford the dentist or new eye glasses that are needed for over two years already, no going out and you stop all extras. Add water to shampoo, less baths, wash clothes farther out. No vacations. No movies. No eating out. NO getting sick. Stop all driving unless it is to work. No shopping for any new clothes, underwear, socks, coats for winter, shoes, personal items.”
- Zachary, Seattle: "I work at a private school and often times have to go to the food bank across the street on lunch. I work very hard on social work and barely make ends meet. My girlfriend and I would like to start a family, buy a house, and plan, but unfortunately we can't responsibly find a way to save for any of them.”
- Robert, Port Orchard: "One of the things that my wife and I used to do to keep up with bills was to use one credit card to pay another. This is a trick that many struggling people use, and we were struggling at times because of surprise expenses. The difference an extra few dollars makes is critical."
- David, Edmonds: "My sister not only goes to the food bank — she washes her clothes in her bathtub to avoid paying a machine."
- Amber, Seattle: "I volunteer at a church on Wednesday nights to help with the Church dinner because they need the help AND I get to take home some of whatever is left over, which I eat all week. This week it will be fried chicken and asparagus, Thursday, Friday, Saturday, Sunday & hopefully through Monday.”
- Elizabeth: "On more than one occasion I have had to scour the house to find enough change to go to the dollar store to buy toilet paper. Such a simple item but without basic necessities being covered by food stamps and working for low wages despite having a bachelor's degree this is something my family has had to do to get by.”
- Craig, Granite Falls: "I had to sell my DVDs to a pawn shop. My game systems, my books, records. Everything I accumulated from my childhood, just to make ends meet. I may never get all that back. The memories alone made me cry. I had no choice. Pay bills or lose everything. It's not fair, I work my ass off and I lose my childhood over it.”
What have you done to make ends meet? Share your story with us, and we'll make sure state legislators get the message.

domain: economics


Website maintenance contracts, are they a waste of money and how do you justify the spend if everything is going on behind the scenes.
I wanted to share why I believe it’s important to keep a website up to date and secure, to do this, I need to roughly explain what WordPress is and how it works.
WordPress is a website platform, it’s the heart of your website, very much like the poles in a tent or the chassis of a car. WordPress is written in a programming language (code) called php. Both WordPress and php are open source code solutions (open source means that you don’t pay a fee to use them).
Being open source means that WordPress and php are constantly developed by a team of enthusiastic experts to make them more efficient and feature rich. Because of this, the code and standards used frequently change, this change happens out of necessity. For example a change may be implemented to close a loop hole that hackers exploit, it could be that a certain code uses too many server resources and has been deprecated and replaced by a new smarter and more efficient way of doing things.
Once the code has been updated, it is then passed down to the users as a WordPress Core update or theme or plugin update, these updates then have to be installed on your website to keep it safe. There is no fixed schedule to when updates happen, they are identified, tested and then rolled out, very much like Apple updates iOS on their phones.
If left unchecked, updates will build up behind the scenes and leave your site vulnerable to attack. It could cause your website to stop displaying properly. This isn’t a scare tactic to squeeze money from you, I have seen many times where a WordPress website owner hasn’t applied updates and the site has been hacked, the usual result is the web page being diverted to a porn or gambling site completely damaging the domains reputation with search engines and causing embarrassment for the owner.
That’s why updates happen and why maintenance is essential to keep your website safe.
What to look out for in a maintenance provider
Admittedly, there are providers offering services to clients that are a waste of money, these are usually bundled into a new website build and you kinda get hooked into signing up for a minimum of 12-months and blah blah they don’t really do very much for the money and you feel disappointed. Admittedly this isn’t always the case, but this is where most website owners get stung.
A good maintenance service will show a list of provided services up front, describing what’s included and what isn’t and the type of communication provided.
Some of the basics that should be included in a maintenance contract.
- WordPress Core Updates
- WordPress Theme Updates
- WordPress Plug-in Updates
- Backup Service
- Security Installation
- Security Scan
- Malware Detection
- 24/7 Downtime Detection
Services are usually provided in price tiers based on the response time and regularity of security checking and backups.
A basic package will offer a monthly update, security sweep & backup service and for most WordPress website owners this is sufficient. If you have a more dynamic website, like an ecommerce store or systems critical sites, you would be better off on a weekly or even daily contract.
Check to see if any labour time is included in the contract, some offer a number of hours included to complete changes / backup restore / migration, usually to keep monthly costs low the service will bill out any extra development time taken.
It’s important to compare what services are included, how changes and updates are reported and what time is included in a maintenance support contract. If no support hours are included, find out what the hourly rate is and if you will be provided with a fixed rate estimate before any work is undertaken.
If you would like to learn more about WordPress Maintenance, please visit the WordPress Maintenance Page >


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Hoop it up while learning skills, coordination, agility, team work, and sportsmanship.
Learn about the Pleasant Hill Baseball Association.
Join our Youth Flag Football program sponsored by the National Football League.
This soccer ‘school’ is a recreational setting for children to learn soccer through age-appropriate skill demonstrations, games, and instructional scrimmages in a safe, non-competitive environment.
Discover the fun of tennis with camps, mixers, clinics, and monthly lessons.

domain: hobby


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Arteta has sent a message this week suggesting Arsenal 26-year-old is set for the exit door - TBR View
Arsenal signed Alex Runarsson last year as Emiliano Martinez’s replacement at the Emirates.
However, the Icelander’s time with the Gunners hasn’t gone to plan thus far.
Runarsson made mistakes last season, including an error-strewn display against Manchester City.
In the end, the 26-year-old ended up becoming third-choice as Mikel Arteta recruited Mat Ryan on loan from Brighton.
Despite Runarsson’s issues, the Arsenal boss insisted in February that the player was an important member of his squad.
“He works really hard,” The Mirror quotes Arteta as saying. “Has fit in really well around the dressing room.
“He is a really nice boy, really humble, and he needs to be away from all the comments and focus on his work, focus on improving.
“You have to be able, if you want to play here, to handle that pressure.
“Alex’s role was very clear around the squad… that hasn’t changed.
“Then, he needs to earn his opportunity and he needs to earn his place.
“He is third, second or first, depending on his performance. He needs to push for that.”
However, Runarsson was a notable absence from the Arsenal matchday squad to face Hibernian on Tuesday.
Hale End graduate Arthur Okonkwo was in the starting XI, while Karl Hein was on the bench.
And now, football.london has claimed that Arsenal are looking at bringing in a homegrown player to fill the role of second-choice.
It looks as though Arteta has sent a clear message suggesting Runarsson is set for the exit door this summer.


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Published at Monday, November 27th 2017. by rudolf in Fish Tank.
For those people who still want to have pets but are scared of the commitment they can choose fish as pets. Fish dont need walks, bath, or special visits to the vet if they are not well.
Besides the sheer size, the decorations that you can stuff in it, as well as the fish varieties that it can house, can leave one awe-struck. Hence, if you can afford it, you should definitely go for a big fish tank - it will add exceptional glamour to any room or place.
When you have decided that it is time to learn how to set up a fish tank the first thing you need to know is there are lists of things you are going to need to get started. Of course you are going to need the fish tank, next you will need a filter system, then a heating system and the right kind of gravel will also be needed, then water and a fish tank lid with a light in it. Another important thing you will need to consider is ornaments for the inside of your tank. This could be anything from driftwood, bought fake ornaments to live or plastic plants.
Nitrate actually encourages the growth of algae in your fish tank. Some fish feed on this kind of algae - but usually not enough, they do not consume all of it, and some consume none. Nevertheless, you will (from time to time) have to scrub your fish tank clean of the buildup of algae. If you cycle your fish tank using a biological fish tank filtration system, you can certainly create a biological environment. When you have already designed a specific biological habitat, and if you purchase a new biological filtration system, your fishes etc. will not have to adjust.
There are many ways where small is beautiful; however, in this matter, the opposite may be correct. A big fish tank is always better than a small one because it can show much more diversity and also hold larger size species of fish that are far more interesting than the small ones.
Any content, trademark’s, or other material that might be found on the newportconsgroup website that is not newportconsgroup’s property remains the copyright of its respective owner/s. In no way does newportconsgroup claim ownership or responsibility for such items, and you should seek legal consent for any use of such materials from its owner.
Copyright © 2018 newportconsgroup. All Rights Reserved.

domain: biology


U.S. Border Patrol agents in Florida took three illegal migrants from China into custody late Friday night after the trio used a boat to make landfall on a Florida beach in a suspected smuggling attempt.
The group washed up in Hillsboro Beach, according to a tweet posted by Miami Sector Chief Patrol Agent Walter N. Slosar.
In less than a week, Border Patrol reported over 150 encounters by boat of mostly Cubans, according to Slosar.
In the news: Georgia Cop Chose The Wrong Florida County In Attempt To Meet Prostitute
The sector has seen a recent influx of migrant crossings. Between October and July, border authorities in the sector encountered 2,499 migrants, according to U.S. Customs and Border Protection (CBP) statistics.
Cuban migrants, who have also arrived by boat, make up the majority of sector encounters in fiscal year 2022. On Monday, Border Patrol took 15 Cuban migrants, whose boat landed in Haulover Beach, into custody.


text: Approximately 15mm puffed coin paintbrush jasper gemstone beads. There are 24-28 beads per 16" strand. Paintbrush Jasper ~Descriptive. These beads have been enhanced to bring out their natural beauty. Paintbrush jasper is also known as artistic jasper, landscape stone, and crazy horse stone. Questions? Call our friendly sales staff at 1-800-366-2156, or email us.


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Summaries A young female landowner in 1840s Jamaica marries a just-arrived Englishman to avoid losing her property. All seems to be perfect, love arises, and happiness is on the way, but she is hiding an old secret regarding her childhood and her mother.
In this prequel to Jane Eyre, Edward Rochester finds himself in Jamaica looking to make his fortune. As the second son, the expectation is that his brother will inherit the family estate and so his future must lie elsewhere. He soon meets Antoinette Cosway and is offered a substantial dowry to marry her.
People also ask
Where does the story of Wide Sargasso Sea take place?
Who are the actors in the movie Wide Sargasso Sea?
Why is Wide Sargasso Sea considered a feminist novel?
When was Wide Sargasso Sea by Jean Rhys published?
Wide Sargasso Sea Antoinette's story begins when she is a young girl in early nineteenth- century Jamaica. The white daughter of ex-slave owners, she lives on a run-down plantation called Coulibri Estate.
Wide Sargasso Sea Summary Wide Sargasso Sea begins in Jamaica after the Emancipation Act of 1833, under which Britain outlawed slavery in all its colonies.
May 07, 1993 · "Wide Sargasso Sea" was directed by John Duigan, an Australian director not familiar to me until I saw " Flirting," one of the best films of 1992. That was a film about a romance between two kids at boarding schools.
Last Updated on May 5, 2015, by eNotes Editorial. Word Count: 762. Jean Rhys’s Wide Sargasso Sea is an exploration of the life of a literary character from another novel. In Charlotte Bronte’s ...
Wide Sargasso Sea explores the power of relationships between men and women and discusses theme of race, Caribbean history, and assimilation. Rhys lived in obscurity after her previous work, Good Morning, Midnight, was published in 1939.
Wide Sargasso Sea is a 1993 Australian film directed by John Duigan and starring Karina Lombard and Nathaniel Parker. It is an adaptation of Jean Rhys 's 1966 novel of the same name.
- 9 min
- miss afizah

domain: entertainment


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Deformation behavior of rocks and resulting structures
Physical Geology Lecture Outline
The picture to the right was taken from a helicopter and is from merging glaciers in Svalbard Norway. Glaciers are rock bodies that deform both ductilely and brittlely at the earth's surface, and hence give insight into this behavior. The various fold forms in the glacial ice give evidence as to the nature of the ductile deformation, while the crevasse field represents brittle deformation. The dark stripes are moraines, formed when rock debris from the mountain The key is that the bonds that hold the ice together are much weaker than those which hold silicate minerals together, and the melting temperature of H2O is much less than that of silicate material, and so ice deforms readily at the earth's surface, whereas silicate rocks do not.
Important concepts in deformational behavior of rocks:
What are important factors in deformation behavior and what is their effect?
Types of brittle structures:
Types of ductile structures:
This is a beach cobble of some of the Fransciscan melange found along California's coast, in this particular case at Patricks Point. Note the white features - these are brittle extensional features known as veins. High fluid pressures help open up these cracks, and then quartz minerals grew out of those waters to form the white veins.
This beach boulder is also from Patricks Point, and shows chert layers folded in a complex manner. These chert layers were orginally deposited as deep ocean silicious oozes (from the skeletal elements of some types of plankton). These melange rocks are characterized by a very complex history of deformation that combined brittle with ductile deformation.
Brittle-ductile transition in the crust:
This is a view looking along the San Andreas fault, where the y axis is depth below the earth's surface in km, and the x axis is distance along the fault in km. Each dot represents an earthquake. Note how the earthquakes occur mostly above 15 km or so. That is because at lower levels the rocks are two hot and ductile to break, and instead the fault movement is by steady, ductile creep. Here you can 'see' the seismogenic part of the earths crust. One can also note some sesimic gaps in this data. Image from: http://3dparks.wr.usgs.gov/pp1515/chapter5.html .
Migmatites: this represents a special rock a mixture of metamorphic rock and often irregular veins of melt (usually granitic) that occurs at deep levels in the crust, usually when the crust has been thickened beyond normal. Migmatites deformed in very complex and arguably chaotic way.
Migmatite is often used as a building stone. This is a slab of migmatite from the Adler planetarium along Chicago's shoreline (near the aquarium and Field museum). The horizontal field of view is several feet. The darker material (also known as the melanosome) is the older meatmorphic rock, in this case amphibolite. The lighter and reddish material is granite, and was magma when this rock was at its peak metamorphic conditions down in the earth's crust. You can see how the older metamorphic amphibolite has been folded and also intruded by irregular veins of the granite magma. Some of those granite layers are in turn folded, clearly indicating deformation and intrusion were happening at the same time. Sometimes the granites formed from the partial melting of the adjacent metamorphic rock, and sometimes it is from injection of magma from elsewhere. This is the geologic record of a juicy deep interior of a mountain belt.
This is an image of a crater on Venus that has been heavily dissected by a series of faults. Many other planetary bodies show faults and folds and other features that result from tectonism. Image source: http://astrogeology.usgs.gov/Projects/VenusImpactCraters/venus_modst.html
© Harmon D. Maher Jr. May be reproduced for non-profit educational purposes with source acknowledgement. Otherwise please contact me.
Return to Physical Geology index page.
Return to my home page index.

domain: geography


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Bull and Bear Go To Market
Learn about the difference between bulls and bears—markets, that is!
Have A Question About This Topic?
Have you found yourself suddenly single? Here are 3 steps to take right now.
What's your vision of retirement?
International funds invest in non-U.S. markets, while global funds may invest in U.S. stocks alongside non-U.S. stocks.


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Professor’s article inspired by college alum
Author LeAnne Howe’s baseball novel “Miko Kings” stands at the heart of a scholarly article published by OCCC English Professor Michael Snyder.
The essay entitled “Imagine Lennon as Choctaw Code Talker: Indigenized Beatles in LeAnne Howe’s Miko Kings” appeared in the Fall of 2014 in the Journal of the Native American and Indigenous Studies Association.
Snyder said he has a passion for the Beatles.
He became interested in Native American literature while attending the University of Oklahoma. His mentor at OU recommended a class about global fiction and Snyder read the book “Miko Kings” for his class.
He said he became thoroughly interested in this novel and wanted to research it more.
Howe is an enrolled citizen of the Choctaw Nation of Oklahoma.
She serves as Edison Distinguished professor of American Literature in the English Department at the University of Georgia.
The prize-winning author once walked the campus of OCCC, attending here in 1970s during the second and third year the college was open, then called South Oklahoma Junior College.
Her most recent novel “Miko Kings” was published in 2007.
It tells the story of the turbulent days before statehood when white settlers and gamblers were swindling the Indians out of their land. This novel connects Native American heritage to baseball and is based on America’s first moving picture, “His Last Game,” according to LeAnne Howe’s weblog.
Being an avid Beatles fan, Snyder found some unusual references in Howe’s novel and was curious about how they related, starting with the main character named John Lennon..
Through research and reading more into the novel, Snyder quickly realized the main character’s name sparked a sense of comparison to the rest of the story.
“My path that I took in trying to solve this mystery kind of parallels the main character in the novel because she is trying to figure out the mystery of this Indian territory baseball team,” Snyder said.
The connection and reference to the “sun” brought the comparison to Snyder’s attention.
The Beatles have a variety of songs that reference the sun such as “Sun King” and “Here Comes the Sun.”
“It’s almost like they are sun worshippers and Howe made it part of the connection,” Snyder said.
Throughout the novel there are different references from the characters to the scenes that can link the Beatles to the novel and use Lennon to call attention to Native American issues.
“All of the characters in ‘Miko King’ reflect John Lennon in some way,” Snyder said.
After meeting with Howe, Snyder nominated her for the OCCC Alumni Hall of Fame, On Nov. 18, 2014, Howe was inducted into the Hall of Fame.
“She is absolutely one of my favorite living writers, even though she has only had a handful of books,” Snyder said.
Her first book, “Shell Shaker” received an American Book Award in 2002, from the Before Columbia Foundation.
It then became a finalist for the 2003 Oklahoma Book Award, and Howe was named Woodcraft Circle Writer of the Year in 2002.
Howe said she was impressed with Snyder’s article when she first read it during their meeting.
“Professor Snyder’s article is well researched, well written,” Howe said.
“It was accepted in an international peer-reviewed journal with very high standards,” she said.
“In other words, Snyder’s article was competing with scholarly articles from around the world for a place in the NAIS journal — a stunning achievement.
“I’m not saying that because the article is about my novel, rather I’m saying that the article twins the Beatles and Native literature.”
LeAnne views the journal article written by Snyder as a unique view of ‘Miko Kings.’
For more information contact Snyder at email@example.com.
To contact Laura Carter, email firstname.lastname@example.org

domain: library


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- Special Sections
- Public Notices
VAN WYCK – Welcoming cheers and words of thanks greeted Van Wyck native and two-time Olympic medalist Shawn Crawford when he returned during the Celebrate Van Wyck festival Saturday to sign autographs and greet friends.
If you currently subscribe or have subscribed in the past to the Lancaster News, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.


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Early on in a relationship, you’ll likely be looking for a few signs of a very good relationship. Should your partner is definitely showing you a great amount of passion and interest in you, then you are most likely on the right track. If perhaps not, it might be a good idea to stay with being friends. But if you sense like onebeautifulbride.net mail order bride your marriage is stalled or just obtaining boring, you must give it a second thought.
One of the most significant quality of any good romantic relationship is healthy communication. When both lovers are receptive to one another’s words, chances are the relationship can be on sound ground. Though everyone has their particular communication models, you should try to be open and honest along with your partner. When you can express yourself verbally and have the valor to voice your opinion, your relationship will probably last. If your partner may the actual same, you may be sure that the partnership will be healthful and previous.
While there are no definitive indications of a good romantic relationship, there are certain characteristics that are distributed by a healthier one. Healthy and balanced relationships happen to be long-term and also have both partners’ independence and style. The relationship could also evolve jointly partner develops older and changes his or her needs. Often , people turn partners plus the relationships may evolve appropriately. These types of changes sign the appropriateness and motivation of every partner. Any time these evidence are present within your relationship, the relationship is most likely healthful.
Respect and appreciation for one another are usually important. Healthy and balanced relationships usually do not shame or criticize their partners for their flaws or other flaws. Rather, they reverence each other’s boundaries and personal space. Additionally, it is essential to consider that a lover’s needs may not always line-up with your own. Additionally , a healthy relationship encourages the need to express arguments. If an individual partner is disrespectful toward one more, it is important setting limits and honor your partner’s likes.
An interest and just like factor are two key elements to get a good relationship. Both are important, since these indicators will be related to trust. A relationship that does not motivate passion and excitement is probably not healthy. If you find yourself feeling perplexed and uncertain of your partner’s interest, consider staying good friends. If the different person appears to be uncomfortable with this, you should reconsider for you to decide. A relationship that does not match these conditions is a red light.
Healthy romantic relationships are open up and genuine. Both parties should feel free to exhibit their feelings, without being defensive. An open conversation style helps to build trust and assurance between the two parties. Inevitably, a healthy romance promotes emotional openness, and doesn’t encourage defensiveness. You should also realize that men who all do not just like the way anyone looks or the method you work are not in love with you. In case your partner is constantly changing both you and denying your needs and requirements is a signal of anxiety and stress in your romantic relationship.

domain: sociology


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Our Commitment as a breeder:
- To breed with working dogs out of the top Labrador field trial and hunt test bloodlines
- Our puppies carry the intelligence, trainability, and instincts to go as far as you would like in hunting retrievers, resulting in top hunting companions and first class family members.
- All puppies are socialized from the first day they are born.
- Introduced to birds at 5 weeks.
- Start early training: sit, here and stay.
- Introduced to crate for easy house training
Labs are naturally born to hunt and make wonderful companion dogs with a natural family oreinted temperament.
The Labrador Retriever is unusually adaptable, obedient and kind-hearted. They are sociable, affectionate and loyal with a keen sense of smell. No wonder they are so popular!!!
What more can you ask for?

domain: pet


The Failings of the Scheduled Airline Market
April 13, 2005 Leave a comment
Few airlines have proved to be good long-term investment in liberalized markets. As a whole the United States’ airlines have failed to earn an overall profit since the passing of the Airline Deregulation Act, and the European industry has done little better. Dr. Button about the failings of the scheduled airline market.


A sophisticated awning striped rug in classic colors of midnight, grey and white has an urban coastal vibe. This new addition to Dash & Albert's cotton flatweave rug collection is a perfect pairing for any bed. Soft underfoot, reversible and easy on your pocket, Dash & Albert's cotton rugs are renowned for their versatility, affordability, and durable construction.
- Material: 100% Cotton
- Dimensions: 2 x 3 ft
- Wash and Care: Handwash gently in cold water. Do not machine wash, bleach, or tumble dry.
- Made in India


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Californians would pay more for solar homes
As costly as homes are in California -- the state's Realtors association said Thurday fewer than a third of families could afford a median-priced home -- Californians would pay even more if their home had solar or wind-generated power, according to a survey conducted for the California Energy Commission.
More than 50 percent of those surveyed would be willing to pay more for a home already equipped with solar or wind power technology. The survey also found that more than 60 percent of homeowners would be more interested in a home that has a renewable energy system already installed versus a home that does not.
"These are very promising findings about homeowners' preferences," said Sandy Miller, manager of the commission's "buydown program." "Residents who are considering remodeling their homes this spring should consider installing solar photovoltaics or wind turbines, depending on their site. It makes good sense financially, especially with the current rebates available through the Energy Commission."
To offset the initial cost of a renewable system, homeowners can take advantage of cash rebates available through the California Energy Commission. The buydown program offers residents $4.50 per watt or up to 50 percent of the total eligible system cost, whichever is less. Funds are available on a first come, first served basis until exhausted. As of February there was still almost $20 million available to Californians who install small solar or wind systems in their homes.
Conducted for the California Energy Commission's Renewable Energy Program by Maryland Marketing Research Inc., the survey included 300 California homeowners in San Francisco, Los Angeles, Fresno and San Diego.
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"Lagging Indicator: Economic series that experience their peaks and troughs after those of the aggregate economy. A list of lagging indicators is given as below: · Average duration of unemployment · Inventories to sales ratio, manufacturing and trade · Change in labor cost per unit of output, manufacturing (%) · Average prime rate charged by banks (%) · Commercial and industrial loans outstanding · Consumer installment credit outstanding to personal income ratio · Change in consumer price index for services (%). Source: http://in.docsity.com/en-docs/Economic_Analysis_-_Security_Analysis_and_Portfolio_Management_-_Solved_Quiz_"
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Athens: The biggest earthquake in Greece’s capital, Athens. An earthquake measuring 5.1 on the Richter scale occurred on Friday afternoon. The panicked people took to the streets. According to the Athens Institute of Geo Dynamics, the earthquake’s epicenter is located 23 km southwest of Athens. No injuries or casualties were reported.
The Athens Institute of Geo-Dynamics said there were seven further motions after the first quake, which recorded a magnitude of 3.1. The European Mediterranean Seismology Center says the quake is mild but intense.
Government spokesman Stelios Pettisas told local media that some buildings in the Attica area were damaged. A government spokesman added that police and firefighters are working to rescue those trapped in debris following the earthquake.
Greece’s Ministry of Public Safety has provided emergency helicopter service in the earthquake-prone areas. Greece is considered the most earthquake-prone country in Europe.


Central African Republic’s Constitutional Court today, Monday, confirmed the re-election of President Faustin-Archange Touadera in the first round of a presidential election on December 27 with 53.16% of the vote. The decision may prompt reaction from rebels as attacks often take place in the mornings.
The 48-hour deadline given by a coalition of armed groups for CAR’s government to quit expired around 17/18G Sunday. The self-styled Coalition of Patriots for Change has threatened to over-run the capital, Bangui, and is seeking to overthrow Touadera. The CPC struck at Bangui’s outskirts last Wednesday but were beaten back by federal soldiers, UN peacekeepers, Rwandan and Russian troops. Officials fear the CPC now has fighters inside the city, preparing for more attacks. Touadera’s government reportedly is seeking a UN meeting this week and wants more UN peacekeepers. As of NOV 2020, the UN mission there MINUSCA had 14,293 personnel, most of them soldiers.
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The Vivo V11 runs Funtouch OS 4.5 based on Android 8.1 Oreo and packs 64GB of inbuilt storage with a dedicated slot. The Vivo V11 is a dual-SIM (CDMA and CDMA) smartphone.
Connectivity options on the Vivo V11 include Wi-Fi 802.11 ac, GPS, Bluetooth v5.00, USB OTG, 3G, and 4G. Sensors on the phone include accelerometer, compass/ magnetometer, proximity sensor, and fingerprint sensor.
The Vivo V11 measures 157.90 x 75.00 x 7.90mm (height x width x thickness) and weighs 156.00 grams. It was launched in Nebula and Starry Night colour.


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The raw food diet is becoming a hot topic for discussion amongst Alaskan Malamutes owners, with some boasting its benefits and others claiming it is unsafe. All this discussion leads back to one important question – can Alaskan Malamutes eat raw meat safely?
Alaskan Malamutes can eat raw food safely, but there is currently no research to suggest that a fully raw diet is preferable to a commercial diet.
In this article, we’ll dive into the pros and cons of offering raw food to your Malamute – let’s get straight into it.
- Full Rundown Of All The Items You Need For Your Alaskan Malamute
- Checklist Included
- Includes Grooming Tools, Food, Collars, Harnesses, Toys & Much More
- Raw Meat And Alaskan Malamutes
- What Is A Raw Diet?
- What Are The Advantages Of Feeding An Alaskan Malamute A Raw Diet?
- What Are The Risks Of Raw Diets For Alaskan Malamutes?
- In Summary
Raw Meat And Alaskan Malamutes
Alaskan Malamutes can eat raw meat – their stomachs can safely handle raw meat just as they have since before domestication.
Many owners feed their Malamutes occasional raw treats such as discarded cuts of meat from cooking or bones from the butchers, and this is something that I myself have done for many years.
The longer answer to this question is a little more complicated, especially when you consider the frequency of feeding.
Raw meat can contain lots of harmful bacteria and parasites, which normally get killed in the cooking process. If you are going to feed your Malamute raw meat, frozen meat is typically the safest, as some of the bacteria will be killed in the process.
Also, as with any meat, keep in mind its origin. Raw meat that is intended for human consumption is usually a higher grade than meat that would otherwise be discarded and so may be better for your Malamute.
As we’ve said, the occasional raw treat shouldn’t negatively impact your Alaskan Malamute. For those of you curious about an entirely raw diet, keep on reading!
What Is A Raw Diet?
So, now we know that Alaskan Malamutes can digest raw meat, it’s time to look at the raw diet. The diet is becoming popular amongst Malamute owners thanks to its many supposed benefits, but what exactly is it?
A raw diet is exactly what it suggests – raw food!
Malamutes are fed on a diet of exclusively raw foods rather than the cooked foods that are usually recommended, such as kibbles.
Typically, raw diets consist mostly of raw meats to mimic the diets that dogs would have eaten before domestication. Many raw diets also include some other uncooked ingredients, such as eggs, fruits, and vegetables, to create a more balanced and nutritional diet.
Although the raw diet is becoming more popular, it is still quite a polarising topic, with many Malamute owners strongly against it.
As for us, we remain undecided. We know Malamutes who are very healthy on both the raw diet and a standard kibble diet.
We believe that as long as a Malamute is getting all the nutrients they need to remain healthy and happy, it doesn’t particularly matter where it comes from. It’s much easier to achieve this on a regular dry food diet, however.
Below, we’ve rounded up the pros and cons of the raw diet so you can get a full look at both sides of the argument.
What Are The Advantages Of Feeding An Alaskan Malamute A Raw Diet?
Before we get into the advantages of feeding your Alaskan Malamute a raw diet, we want to make it clear that these are based on other owners’ experiences.
There is currently no research that supports the advantages of feeding a raw diet to dogs over a standard, commercially prepared diet.
One of the most commonly reported advantages of switching to a raw diet is improved digestion. Owners of raw-fed Alaskan Malamutes boast that their Malamutes have smaller, less-smelly poos.
Interestingly, many owners also talk about how their Malamute’s poos dry up into a white chalky powder after a couple of days, making clean-up duty less of a chore. We can’t attest to this, but it’s certainly an advantage we wish we had!
Raw feeders claim that this is because dogs utilize a higher percentage of the food they eat when eating raw food compared to eating commercially prepared food such as kibbles.
Currently, there is no available research to back up this claim, and the fact that the vast majority of Malamutes who are fed commercially prepared food are deemed healthy by vets suggests it is untrue.
Keeps Teeth Cleaner
Raw feeders commonly talk about the improvements seen in their Alaskan Malamute’s dental hygiene after switching to a raw food diet.
They claim that the act of having to chew through tough meats and bones naturally keeps their teeth cleaner by dislodging plaque. Many can completely forgo the daily dental treats that most of us are used to feeding our Malamutes.
We should note here that many vets actually recommend against regularly feeding your dogs raw bones due to the increased risk of tooth fracture. Keep reading for more of our thoughts on this!
On top of this, raw feeders claim that their Alaskan Malamutes have fresher breath when eating a raw food diet. This is attributed to the fact that sugars and starches that sit in a Malamute’s mouth can cause rotting of the gums.
If you regularly give your Malamute dental treats and practice good dental hygiene with them (something that should still be followed on a raw diet), this issue should be prevented.
The shine of an Alaskan Malamute’s coat is often used as an indicator of their health. Glossier coats suggest a healthier dog compared to one whose coat is dull and dry.
Raw feeders often brag about the condition of their Malamute’s coats. Many claim to see improvements to not only the glossiness but also to the softness and overall feel.
The reality is that if your Malamute is consuming a balanced diet with all of the vitamins and nutrients they need, whether that be through a raw diet or kibble, their coat is bound to be shiny.
Better Behavior Towards Mealtimes
Now, this is an advantage that we can believe. Alaskan Malamutes who are fed on a raw diet is said to have a better attitude towards their mealtimes.
Alaskan Malamutes are highly food orientated, so it makes sense for their behavior to be altered by the food they are eating. If a Malamute particularly likes their raw diet or is more satisfied by it, they may beg less in anticipation.
Of course, this also swings the other way. If a Malamute gets excited by their upcoming meal, you could find them behaving more erratically in the build-up to mealtimes. This applies to any diet they are on and is not exclusive to the raw diet.
There are some theories to suggest that eating a raw diet reignites old hunting instincts in Alaskan Malamutes, which could alter their behaviors. There is no evidence to back this up, though.
What Are The Risks Of Raw Diets For Alaskan Malamutes?
Although a raw diet does appear to have lots of benefits for Alaskan Malamutes, there are some risks involved that you should be aware of before making the change.
The most common issue encountered by owners using raw diets is failing to feed their Alaskan Malamutes a balanced diet with all the nutrients they need to stay healthy. Feeding an Alaskan Malamute an unbalanced diet can quickly lead to them becoming unenergetic, moody, and ill.
Commercially prepared dog foods such as kibbles are designed to ensure dogs fulfill their daily nutrient needs without having to add supplements. In many cases, beneficial vitamins are also added to boost their overall health.
If you do choose to feed your Alaskan Malamute a raw diet, we advise you to speak to a pet nutrition specialist.
They will help you to curate a diet plan that will ensure your Malamute stays healthy and works for your budget.
Bacteria And Parasites
Another risk involved with the raw food diet is that raw food often contains harmful bacteria and parasites that would normally be killed in the cooking process. One study found that 25% of raw food samples tested positive for harmful bacteria.
Feeding your Alaskan Malamutes high quantities of raw meat not only increases the risk of them becoming ill but also increases the risk for other household members too.
Salmonella and L. monocytogenes can both be quickly spread to other members of the household from raw food.
If you are preparing raw food for your Malamute, remember to be extra cautious of cross-contamination and try to feed them away from where other household members eat. Thoroughly wash everything after feeding and sanitize all surfaces the food has come in contact with.
Also, keep in mind that their saliva and feces may contain more of these harmful bacteria after eating raw food. Be sure to wash your hands after being in contact with them, and don’t allow them to lick your face.
One last thing to consider happens to be a hot topic for debate in the dog world, and that is the fact that feeding your Alaskan Malamute a raw diet may include giving them bones.
Uncooked bones, like those included in raw diets, undeniably pose less risk to your Alaskan Malamute than cooked bones. Cooking bones makes them splinter much easier, which can cause severe damage to your Malamute’s stomach if ingested.
If you ask the majority of Alaskan Malamute owners, they will tell you that their Malamutes love to chow down on an uncooked bone as an occasional treat to keep mealtimes interesting.
Surprisingly, vets actually recommend against feeding your Malamutes any kind of bone altogether. This is because smaller bones can easily cause blockages in their stomachs if ingested, and regular chewing of bones can cause fractures in their teeth.
Whilst we’ve personally not experienced any negatives from feeding our Malamutes bones, owners need to be aware of potential risks.
If you are feeding your Malamute a raw diet, we recommend staying away from foods that could potentially include small bones. If you choose to feed them the occasional bone as a treat, keep them supervised and watch for any changes in their health afterward.
So, there you have it.
The raw food diet seems to have improved the health of many Alaskan Malamutes, but no scientific research is currently available to back its benefits.
The biggest challenge owners will face with it is ensuring their Malamute is eating a balanced diet with all the nutrients they need. We believe that so long as this is achieved, there is no inherent problem with the raw diet.
Is your Malamute on a raw diet? We’d love to hear about your experience! Please leave a comment below.


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Ave Maria Candle – Church Window
Kauf auf Rechnung
This candle is decorated with a colourful “Ava Maria” motif and reflects the faith and warmth that Mary is met with.
Mary is the first Mother of Christianity. She is the connection between us and God. Often, she is called upon in suffering or distress. With her as a shimmering companion on the kitchen table, the bed side table of a hospital bed or in a shrine at home we can feel protected and comforted.
|Größe:||6 x 5 cm|

domain: artistic


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Save on P!nk concert tickets
The 2019 Beautiful Trauma World Tour starts March 1st in Sunrise, FL. Pink will be touring throughout the U.S. for the next few months and subscribers can save on tickets to her shows!
Log in below to access special discounted tickets. Available while supplies last.
See more subscriber stories and perks.
Click Buy Tickets to view tour dates and select tickets to purchase.


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Toronto – September 10, 2021 – UFCW Canada recently concluded another successful season of the country’s leading labour training program for young activists – the UFCW Canada Young-Workers Internship Program (YIP).
Toronto – September 9, 2021 – Following calls from UFCW Canada and advocacy partners to Ditch Toxic Receipts, Metro Inc. has made a public commitment toend the use of paper receipts coated with toxic bisphenol A (BPA) and bisphenol S (BPS) in all Metro food and pharmacy banners.
Medicine Hat, Alta. – September 7, 2021 – UFCW Local 401 members working at Revera Meadowlands Retirement Residence in Medicine Hat, Alberta have achieved a new union contract that provides wage increases, improved benefits, and more.
Toronto – September 2, 2021 – With less than four weeks left to apply for the 2021 UFCW Canada – BDM Scholarship program, time is running out for your chance to win one of 18 scholarships worth $1,000 each, or one of two Apple iPads.


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They are communists. Bowing to the “hive mind” of social justice. Bowing to the hive mind of mob rule. Little children pretending their adults. Time for the PMP. Patriot Militia Party, standing with the US Justice Department that defends law & order. Standing with the honest hard-working police officers. Standing with the President of the United States of America and not the lying communist influenced social misfits of ANTIFA and BLACK LIVES MATTER both are nothing but communist fronts, pretending to be something they are not. They are not for freedom, they are not for free speech, these people want to be and are trying to be the thought police of America. Two words for all of you. Bugger off.
Every politician who walked with these protestors holding ANTIFA and Black Lives Matter signs should be voted out of office if they can not discern they are backing anti-American communist people and organizations. How politically stupid does one have to be to follow the mob rule? This shows you they are incompetent or disloyal to the country.
You want to defund the police, I say let’s defund the politicians, the universities. Let’s defund the United Nations and all you communist loving youth who have fallen for the lies of the ANTIFA =Against Nations Truth Individuals Freedom America and Black Lives Matter should all move to Communist China where the “hive mind” rules with punishing dictatorial powers. In fact, if you were protesting in Communist China it is likely you would have been killed by the thousands. If you had been in Communist China and rioted and attacked the police and burned down buildings and looted you WOULD HAVE BEEN SHOT. And if you survived and were caught you would be tortured and made into a slave or executed. Have you ever even been outside of America? No, you have not.
And you poor little communist think you have it so bad, and injustice in America is so awful that every police officer is a pig. We were told this same lie’s in the sixties. Abby Hoffman, Jerry Rubin, Angela Davis. Alternative media in cities around America portrayed the police as demons and the soldiers drafted and forced to go to Vietnam treated like trash when they came home. Yet you all still are free to protest. You are only asked to obey the law and protest peacefully. Yet your thought police have turned you into a mob of unwitting fools.
Yet those of us who grew up hearing and falling for the lies of these communist traitors with the Tune In Turn On Drop Out mantra was offering a social utopian lie. Just like we are hearing today from AOC, and all the other voices of ignorance, shouting “Defund the Police.” We will not allow America to fall any further into the hands of dogs and swine. They have cast their pearls before swine and they have thrown what is holy to the dogs. Freedom is a holy thing. These modern-day communists are little children with big heads and flowery ideas of power and unity of the “hive-mind.” Though the riots and destruction of property, the injuries of both sides and the deaths of both sides is horrible, law and order must be maintained or we will lose America.
There are plenty of bad cops, but the overwhelming majority are honest police officers. There are plenty of cops with bad attitudes, yet the overwhelming majority are no different than your father or brother or sister or uncle and mother or neighbor. We live with these officers of the law when they are off duty do you see them bothering people getting in trouble no more so that you or I.
The problem is the system is rigged by the political decisions that force people into situations where they feel trapped and hopeless by being charged with crimes that are simply passed by politicians to bring in revenue to the states. Criminal justice should not be private and it should not be profitable for the counties, cities, and towns or the states. It should not be a business made to bring in revenue by passing laws that entrap people into money debt or allow the police to confiscate the property of people not even convicted. Or convicted of crimes that have nothing to do with their property.
Prisons are for people who society has said and demands they pay for something they did. Debt has been incurred, but not a financial debt but a moral deft. A moral debt that must be paid by being isolated from society and offered the opportunity to reflect and change. But now prisons are refugee camps between crimes defendants are found guilty of as they are caught and sent back over and over. And the system continues to reap in the profits by adding charges upon charges to the to force people into submission, instead of rendering justice. The politically elected officials are the problem, not the police. But today with the liberal hive mind they want to lock up the police and let the criminals out. Politicians pass the laws the police enforce why do you not call out the politicians? Ah, you gotta love the ability of people to turn truth into a lie and a lie into the truth. Hendrich Himmler of the NAZI SS said something to that effect. The elected officials like Nancy Pelosi, Mitt Romney, Adam Schiff, Chuck Schumer, AOC, O’mar these are the problem. As well as State officials like the clown guv nut of VA who would murder babies while the woman is in labor. That is pure evil. And these are the people who are voting over and over into the office. Let’s defund their pay, their benefits, their health care, and all their perks. Defund the Congress, it is filled with corrupt backing stabbing communist liars.
PMP armed citizens who back the Constitution and the Bill of Rights, all of them. That means we follow the law. If we get arrested we will defend ourselves in a court of law. Not by attacking officers of the law who would come to my defense if I was being attacked or assaulted. Most officers of the law no matter if its a man or woman, court clerk, corrections officer, or officer patrolling the beats are no different than you and me.
Cops Live’s Matter too.


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Sometimes the real star of the silver screen is the score. During the golden age of Hollywood, everyone from classical composers to Broadway songwriters would try their hand at writing large-scale compositions for motion pictures. What they created was the foundation of the pops sound.
On this episode of American Pops, Michael Feinstein features some of his favorite orchestral pieces originally written for film, but that stand alone as concert works. The program includes Johnny Green’s Overture from "Raintree County," Milkos Rozsa’s theme to Hitchcock’s "Spellbound" and Korngold’s score to "The Constant Nymph."


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WandaVision was the first, and I think to this point, the most acclaimed of Marvel’s many shows on Disney+. And now we’re finding out that it will be the launching pad for not just one spinoff, Agatha: Coven of Chaos, but a second one that will feature the return of Paul Bettany as Vision.
Deadline reports Vision is set to return for Vision Quest, from WandaVision and Coven of Chaos writer Jac Schaeffer. That title shouldn’t be confused with the 1985 movie starring Matthew Modine, but is based on the integral West Coast Avengers storyline that saw Vision dismantled and his ability to have human emotions and feelings wiped out. He also was given the chalky white exterior that was seen briefly during WandaVision, a visual representation of the cold, unfeeling machine that Vision became when reconstructed by SWORD, the intergalactic peacekeeping organization that has replaced SHIELD. SWORD will be seen again soon in both Secret Invasion and The Marvels.
I would expect the Vision Quest series to make significant changes from the comics. It’s unclear if Elizabeth Olsen will show up as Wanda, although it seems likely she’ll at least make a cameo. And what about other members of the West Coast Avengers? Perhaps Wyatt Russell’s USAgent now that he’s part of the MCU? And what about Wonder Man sine he is also getting his own series? Lots to ponder.


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Entries on the topic of “Anteloper” 1 results
Twice a month, CHIRP DJ and Features Co-Director Mick takes a deep dive into two albums currently in rotation on CHIRP's charts that he thinks are worth some special attention. If you haven't given these albums a listen in their entirety, let Mick make the case for why you should!
Tour Beats Vol. 1
Releases made exclusively for tours were at one point a novel concept, then a necessity, and now seemingly a quirk of the recent past. With no one touring we have seen a steady declassification of releases once only meant for archives and merch tables.
Most of these “exclusive albums” are underwhelming and were probably better left in the vault, but there are gems to be found amongst the raft of recent Bandcamp rough. One such notable is Tour Beats Vol.1 from Anteloper.
Tour Beats is the product of a month-long residency by the Red Hook native and trumpeter Jamie Branch at the studio of the Brooklyn-based community center, Pioneer Works back in 2018. Anteloper as a band began when Branch invited drummer Jason Nazary to join her in utilizing the recording space, a converted shipping container, to improvise a sound collage with her.


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A thick, bulging waist is something many people do not desire.
Now these indications of central weight problems can have fatal effects, according to the British Medical Journal.
Examining more than 15,000 American males and females, researchers found that those with a larger waist– something suggesting they had “central weight problems”– were two times as likely to have a sudden cardiac death, or SCD.
SCD, unlike a cardiac arrest, is caused by an unusual heart rhythm, and is usually fatal when it happens.
“From a mechanistic point of view, there are a number of factors why a comprehensive assessment of weight problems as a danger factor for SCD is required,” compose Kyndaron Reinier and Sumeet S. Chugh, who wrote an accompanying editorial to the research study in the journal Heart. “Obesity is connected with a range of ECG irregularities, including long term ventricular repolarisation (QT interval), which enhances sensitivity to ventricular arrhythmias. The public health burden of sudden cardiac death (SCD) is high, making up about 50 % of cardio deaths, and leading to more years of possible life lost than any single cancer.”.
In the study, researchers gathered information from almost 15,000 American males and females in between 45 to 64, who had actually previously participated in the Atherosclerosis Risk in Communities (ARIC) research.
Tracking their weight, height, waist circumference, and waist to hip ratio, researchers examined if any of these data associated with either a greater or lower risk of SCD. Though few individuals developed SCD during the study, it was enough to make an analysis– 253 established SCD throughout the 12.5 year tracking period.
Their greatest discovery?
Having a higher body mass index, or BMI, together with a bigger waist to hip ratio, a sign of central weight problems, enhanced their danger of SCD by 50 percent.
Other risk elements, such as hypertension and high cholesterol, also enhanced the probability of SCD.
“Obesity likewise enhances risk for cardiac arrest, LV hypertrophy and dilatation, rest apnea, and altered supportive tone, all which may increase risk of SCD beyond conventional CVD danger,” write researchers. “Traditionally, BMI has been used in analyses of obesity and outcomes, however there is a growing literature recommending that the distribution of body fat is very important in identifying heart disease (CVD) danger.”.
What This Means For You?
SCD is practically constantly fatal when it strikes– but there’s now evidence recommending a brand-new method to combat it. To reduce your danger of SCD, reducing your weight is essential, specifically if you’re vulnerable to central obesity. Merely staying active and avoiding overeating can fix these issues, however– though that’s much easier stated than done.
Midriff Bulge Linked to Heightened Risk of Sudden, Often Fatal, Heart Malfunction – ScienceDaily.com
Obesity and Sudden Death: Visceral Response? – BMJ.com
Obesity Related Risk of Sudden Cardiac Death in the Atherosclerosis Risk in Communities Study – BMJ.com

domain: medical


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1 XL Congresso Nazionale LIMPE VII Convegno Nazionale DISMOV-SIN ROMA Ergife Palace Hotel Via Aurelia, ROMA ABSTRACTS
2 INDICE COMUNICAZIONI ORALI PAG. 3 VIDEO PAG. 17 POSTER PAG. 23 INDICE AUTORI PAG. 136
3 COMUNICAZIONI ORALI
4 C1 Brain functional connectomics in early Parkinson s disease Massimo Filippi 1,2, F. Agosta 1, S. Galantucci 1, I. Stankovic 3, A. Meani 1, P. Valsasina 1, I. Petrovic 3, G. Comi 2, V.S. Kostic 3 1 Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan 2 Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan 3 Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia Introduction: Brain connectomics are promising in the study of neurodegenerative diseases. The analysis of brain networks in Parkinson s disease (PD) could improve the disease understanding. Objective: To examine the integrity of the functional brain connectome in early PD. Methods: We enrolled 44 early (Hoehn and Yahr=1.2) PD patients and 27 controls. Graph analysis was applied to resting state functional MRI data from both groups. Functional connectivity between 90 cortical and subcortical brain regions was estimated using bivariate correlation analysis and thresholded to construct a set of undirected graphs. Measures of global and regional network properties were obtained. Results: Functional brain networks in PD patients did not show loss of small-worldness and differences in global network measurements. Bilateral middle and superior temporal, superior frontal, postcentral, right middle frontal and inferior temporal gyri, left middle occipital gyrus and precuneus were hubs in both groups. Right superior temporal pole was hub only in controls. Right calcarine cortex, cuneus, middle occipital gyrus, precuneus, anterior and middle cingulum, superior-medial frontal gyrus, and left inferior parietal and lingual gyri were hubs only in patients. The analysis of regional nodal characteristics in PD showed decreased nodal degree in supplementary motor area, middle temporal gyrus and superior temporal pole bilaterally, and decreased betweeness centrality in left Heschl s gyrus and rolandic operculum and right angular gyrus. Conclusion: Graph analysis showed that global structure of brain networks in early PD is preserved. However, the analysis of regional nodal characteristics showed that network changes are detectable in early PD in key areas for the disease. Connectomics in PD may add new light to the understanding of the pathophysiology of the disease and of the mechanisms underlying the development of symptoms and response to treatment. Funding: Italian Ministry of Health (#GR ); Ministry of Science and Technology of the Republic of Serbia (#175095).
5 C2 Late-onset parkinsonism in NF-kB/c-Rel-deficient mice: insights into novel drugable targets Marina Pizzi 1,2, C. Baiguera 1, M. Alghisi 1, A. Pinna 3, A. Bellucci 1, M.A. De Luca 3, L. Frau 3, M. Morelli 3, R. Ingrassia 1, M. Benarese 1, V. Porrini 1,2, M. Pillitteri 4, G. Bertini 4, P. Fabene 4, S. Sigala 1, M.G. Spillantini 5, H.-C. Liou 6, P.F. Spano 1,2 1 University of Brescia and National Institute of Neuroscience, Brescia 2 IRCCS San Camillo Hospital, Venezia 3 University of Cagliari and National Institute of Neuroscience, Cagliari 4 University of Verona, Verona 5 University of Cambridge, Cambridge, UK 6 Weill Medical College of Cornell University, New York, NY, USA Nigrostriatal dopamine (DA) neuron degeneration, synaptic dysfunctions and neuroinflammation are among the key pathological features of Parkinson s disease (PD). NF-kB factors are considered cardinal players in the progression of the neurodegenerative process, with dual effect on inflammation and apoptosis. While NF-kB/RelA factor acetylated on the lysine 310 residue is responsible for the commencement of apoptotic gene expression, NF-kB/c-Rel factor promotes transcription of anti-apototic genes, MnSOD, Bcl-xL and UCP4. Aim: To investigated possible age-associated neurodegeneration in c-rel-/- mice. Methods: WT and c-rel-/- mice were analyzed at 2, 12 and 18 months of age for their motor behaviour and brain neurochemistry and pathology. Results: At 18 months of age, c-rel-/- mice exhibited a significant loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), as assessed by TH IHC and Nissl staining. SNc degeneration was accompanied by a significant loss of DA terminals and a significant reduction of DA and HVA levels in the striatum. Mice deficient of the c-rel factor exhibited a marked immunoreactivity for fibrillary a-synuclein in the SNc, increased level of DMT1 and iron. Aged c-rel-/- brain showed increased microglial reactivity, but no astrocytic reaction. In addition, c-rel-/- mice displayed age-dependent deficits in locomotor activity and various gait-related deficits associated with bradykinesia and muscle rigidity. The motor deficits recovered after treatment with L-DOPA. Latest data show that as observed by functional imaging in premotor PD, at an asymptomatic age c-rel-/- mice display early loss of DAT in the caudatum putamen. Conclusion: c-rel factor is a regulator of SNc resilience to aging. It discloses a new therapeutic target deserving further investigation in PD patients. c-rel-/-mice represent an innovative animal tool to study pathological progression of PD and also model PD preclinical phase of dopamine deficiency . References  Baiguera C, Alghisi M, Pinna A, Bellucci A, De Luca MA, Frau L, Morelli M, Ingrassia R, Benarese M, Porrini V, Pellitteri M, Bertini G, Fabene PF, Sigala S, Spillantini MG, Liou HC, Spano PF, Pizzi M. Late-onset Parkinsonism in NFκB/c-Rel-deficient mice. Brain Sep;135(Pt 9):
6 C3 Default-mode network changes in Huntington s disease Elena Salvatore 1, M. Quarantelli 2, C.V. Russo 1, S.M.D.A. Giorgio 3, A. Cervo 3, S. Cocozza 3, L. Di Maio 1, A. Brunetti 3, A. Filla 1, G. De Michele 1 1 Department of Neurosciences, Reproductive Sciences and Odontostomatology, University Federico II, Naples 2 Biostructure and Bioimaging Institute, National Research Council, Naples 3 Department of Advanced Biomedical Sciences, University Federico II, Naples Background: Huntington s disease (HD) is associated to prominent atrophy in the striatum, a key component of several basal ganglia-thalamo-cortical networks. Functional MRI allows to assess the integrity of these networks even without relying on task-related activations (Resting-State fmri - RS-fMRI). Among these, the so-called Default-Mode Network (DMN) appears to play a central role in the coordination of sensori-motor and cognitive goal-directed activities. Aim: This study aim at evaluates DMN in HD patients and to correlate them to clinical data. Methods: 26 patients seen at our HD Clinics, and 21 age- and sex-matched controls (NV) were scanned by a 3D-T1w volume and a set of T2*w volumes for RS-fMRI analysis, on a 3-Tesla MRI. Correlation analysis between clinical and MRI data was carried out using AnCova (p 0.05). Results: HD showed decreased connectivity with the PCC in five clusters, with reduced correlation at the level of the caudate nuclei, of the ventral medial prefrontal cortex (VMPFC), the right medial superior prefrontal cortex, the right inferior parietal cortex mainly at the angular gyrus (rang), and decreased anti-correlation involving the supramarginal gyrus on the left. The ventromedial prefrontal cortex (VMPFC) cluster showed a significant positive correlation (p=0.004) with the cognitive subset of the UHDRS, demonstrating reduced connectivity in more compromised patients, while the rang cluster showed a significant inverse correlation (p=0.008), with relatively spared connectivity in more compromised patients. Conclusion: DMN dysfunction is present in symptomatic HD patients and correlates to cognitive disturbances. This dysfunction is not directly related to the atrophy of the involved cortical nodes, suggesting a possible role of the striatum in regulating a subset of the DMN in the normal brain and/or the effect of the extensive cortical neuronal loss which occurs in HD. Further studies are needed to clarify the mechanisms underlying these alterations.
7 C4 Four-year follow up outcome of Deferiprone for Pantothenate kinase-associated neurodegeneration (PKAN) and Neurodegeneration with brain iron accumulation (NBIA) Daniela Murgia 1 G. Cossu 1, G. L. Forni 3, G. Matta 2, R. Galanello 6, S. Barella 6, M. Balocco 3, R. Marchese 4, U. Ruffiengo 5, U. Bonucelli 7, M. Melis 1, G. Abbruzzese 4 1 Dipartimento di Neurologia Ospedale G.Brotzu, Cagliari 2 Dipartimento di Radiologia Ospedale G.Brotzu, Cagliari 3 Centro della Microcitemia ed Anemie Congenite, Dipartimento di Ematologia, Ospedale Galliera, Genova 4 Dipartimento di Neuroscienze Università di Genova, Genova 5 Unità di Neuroradiologia Ospedale Galliera, Genova 6 Ospedale Regionale Microcitemia, Università di Cagliari, Cagliari 7 Dipartimento di Neuroscienze, Università di Pisa, Pisa Deferiprone (D) is an oral active iron chelator, able to cross the blood-brain barrier and effective in the lowering of intracellular iron. NBIA (Neurodegeneration with Brain Iron Accumulation) is a class of neurodegenerative diseases that feature a prominent extrapyramidal movement disorder along with iron deposition in the basal ganglia. The most common form of NBIA is PKAN (NBIA subtype 1) which accounts for about two-thirds of all the cases of NBIA. The results of our previous one-year-treatment study (Clinicaltrials.gov Identifier: NTC ) suggested that D might be effective in reverse brain iron deposition and improve neurological manifestations in patients with NBIA. Due to these encouraging results we extended the treatment period and 5 out of 6 pts completed a 4 year-follow-up (only in one case, the time of observation was 36 months). In all the patients, D was well tolerated and safe (without any serious hematologic or neurologic adverse even), brain MRI demonstrate a persistent mitigation of the pallidal iron accumulation in 5 out of 6 cases which correlate with a persistent motor improvement (in 1 case) or a clinical stabilization (in 4 cases). Furthermore, in two of these patients, clinical data are available since 4 years before the treatment onset and in both cases D seemed to slow disease progression providing a a further suggestion of the drug effectiveness. The data from our study underline the long-term safety and tolerability of D as a chelator agent for intra- and extraneuronal iron accumulation. The relief or the enduring stabilization of symptoms observed in the large majority of our cohort over a prolonged observation period, together with the MRI data, suggest that treatment with D may be effective in the treatment of neurological manifestations linked with iron accumulation.
8 C5 Wearing off (WO) detection in the clinical practice. The work-pd study (Wearing off real practice key in Parkinson s disease) Antonella Peppe 1, L. Brusa 2, E. Cassetta 3, A. Denaro 4, F. Viselli 5, M.C. Altavista 6 1 IRCCS Fondazione Santa Lucia, Roma 2 Ospedale S.Eugenio, Roma 3 Ospedale San Giovanni Calibita Fatebenefratelli, Roma 4 ICOT, Latina 5 Ospedale San Giovanni Battista, Roma 6 ACO San Filippo Neri, Roma Wearing-off (WO) is defined as a generally predictable recurrence of motor and non-motor symptoms before doses of anti-parkinsonian medication which usually improves after the dose. WO questionnaire with 19 items (WOQ19) was previously identified as a recommended tool to early detect WO and ameliorate the diagnosis. Objective: Evaluating the impact and practicability in real practice of WOQ19 and its capacity to ameliorate clinical detection of WO. Methods: As a multicenter naturalistic observational study patients were recruited in 6 Lazio hospital centers specialized in Parkinson's disease. Any treatment was allowed while patients with cognitive impairment were excluded. WOQ19 was administered to the patients before the visit. During the visit a data collection scorecard was filled with patients clinical characteristics, WOQ 19 comprehensibility and usability and physicians' evaluation about capability to change the diagnosis and modify the visit. Results: 533 patients were included, with a mean age of 72.08, a mean disease duration of 7.7 ±4.6 years and a mean l-dopa treatment duration of 5.61 ± 3.8 years; 50.2% of the studied populations was in stage 3 of the H Y scale, 33.6% was in the stage % (n=352) patients were affected by WO in almost 2 symptoms, with a significant correlation between disease severity and duration, patients age, sex female and l-dopa assumption. WO did not correlated with patients educational degree. Isolated non motor WO strictly correlated with l-dopa intake. WOQ 19 was considered useful in 50% of the patients and diagnosis and visit were modified in almost 15% of the cases. Conclusion: As previous studies our data revealed that WO detected with WOQ19 correlates with disease severity and duration, female sex and l-dopa intake. The questionnaire appeared a comprehensive tool for its lack of correlation with patients educational degree. We suggest its use in clinical practice.
9 C6 Identification of two heterozigous mutations in NPC1 gene in patients affected by late onset neurodegenerative dementing disorders Chiara Cupidi 1, L. Bernardi 1, A. Clodomiro 1, F. Frangipane 1, R. Colao 1, G. Puccio 1, M. Anfossi 1, M.E. Conidi 1, M. Gallo 1, S.A.M. Curcio 1, M. Mirabelli 1, N. Smirne 1, R. Di Lorenzo 1, A. Dardis 2, S. Zampieri 2, R. Maletta 1, A.C. Bruni 1 1 Regional Neurogenetic Center, ASP CZ, Lamezia Terme 2 Regional Coordinator Centre for Rare Diseases, University Hospital "Santa Maria della Misericordia", Udine Background: Niemann-Pick type C (NPC) disease is a lysosomal lipid storage disorder caused by mutations in NPC1 and NPC2 genes. Onset varies from infancy to adults and a broad clinical presentation, such as parkinsonism or behavioural disturbances, makes hard the diagnosis in adults. Although NPC is an autosomal recessive disorder, clinical report and studies on transgenic mice suggest that heterozygous NPC1 mutations could cause neurodegeneration. Aim: We describe two known NPC1 heterozygous mutations in two patients affected by neurological diseases resembling progressive sopranuclear palsy (PSP) and frontotemporal dementia (FTD). Patients and Methods: Patient 1 was a 66-years-old woman affected by a parkinsonism resembling PSP, with limitation of vertical gaze, dysphagia and dysarthria, gait apraxia; mild mental retardation was present from birth. Patient 2 was a 56-years old woman affected by behavioural variant of FTD. Infantile epileptic seizures and a severe depression were reported; at 43 years she presented psychogenic seizures, apathy, emotional lability and impairment of recent memory; frontal dementia associated to left hemidystonia and dysphagia were recognized at 56 years. Brain MRI showed midbrain atrophy in patient 1 and mild frontal atrophy in patient 2. NPC1 and NPC2 genes were analysed from genomic DNA; filipin staining was performed. Results: Patient 1 carries a known heterozygous deletion (F284LfsX26), patient 2 bears a previously reported heterozygous missense mutation (N222S). Filipin staining showed variant biochemical subtype in patient carrying the deletion. Conclusion: The diagnosis of NPC is plausible for the patient bearing the deletion, since she exhibited a clinical picture suggestive for adult NPC and the Filipin staining was positive, whereas it remains doubtful for the second patient carrying the missense mutation. We speculate that heterozygous mutations in NPC1 gene could cause the neurological disorders in our patients and could explain the late onset and the slow progression of disease.
10 C7 Supine hypertension in Parkinson s disease and Multiple System Atrophy revisited: a treatable complication of cardiovascular autonomic failure Alessandra Fanciulli 1,2, J.P. Ndaysaba 2, R. Granata 2, S. Dürr 2, S. Strano 3, C. Colosimo 4, W. Poewe 5, F.E. Pontieri 1, G.K. Wenning 2 1 Department of Neuroscience, Mental Health and Sensory Organs Sapienza University of Rome, Rome 2 Division of Neurobiology, Department of Neurology Innsbruck Medical University, Innsbruck, Austria 3 Department of Cardiovascular, Respiratory, Nephrologic and Geriatric Sciences - Sapienza University of Rome, Rome 4 Department of Neurology and Psychiatry Sapienza University of Rome, Rome 5 Department of Neurology Innsbruck Medical University, Innsbruck, Austria Introduction: Cardiovascular autonomic failure is a frequent non-motor feature of Parkinson s disease (PD) and Multiple System Atrophy (MSA). Beyond orthostatic hypotension (OH), a paradoxical supine hypertension (SH) may develop. Although asymptomatic, SH could exert a major role on survival, cerebrovascular and cognitive outcome in parkinsonian syndromes . Objective: To investigate the prevalence and severity of SH in PD and MSA and to assess its clinical and tilt test correlates. Methods: 178 PD and 70 MSA patients were included in the present cross-sectional study. Cardiovascular autonomic function was evaluated in a standardized setting by means of continuous ECG and non-invasive beat-to beat blood pressure (BP) monitoring (Finapres, Task Force Monitor, CNSystems). Supine BP was evaluated after 10 minutes in the lying position and orthostatic BP changes were evaluated for 10 minutes after 60 passive head-up tilting. Results: SH ( 140 mmhg systolic, 90 mmhg diastolic) was observed in 35% and 36% of PD and MSA patients, respectively. In PD, SH was mild in 69% of cases, moderate in 29% and severe in 2%, while in MSA SH was mild in 48 % of patients, moderate in 20% and severe in 32% (p=0.002). No association was observed between SH and sex, age, disease duration or H&Y stage either in PD or in MSA, but with the presence of cardiovascular comorbidities (p=0.001) and use of anti-hypertensive medications (p=0.03) in PD and use of ant-hypotensive medication (p=0.02) and lower daily dopaminergic intake (p=0.001) in MSA. Amplitude of both systolic (r:-0,292; p=0.000) and diastolic (r:-0,368; p=0,000) BP fall upon tilting significantly correlated with degree of SH severity in PD and MSA. Conclusion: Our results show that one third of PD and MSA patients may suffer from mild to severe SH, independently from age, disease duration or severity. In recent epidemiological and preclinical studies, potential neuroprotective effects from Calcium antagonists of the dihydropyridine class have been reported in PD [2, 3]. If replicated in future studies, administration of short-acting Calcium antagonists may represent promising therapeutic candidates to achieve anti-hypertensive effects in parkinsonian syndromes. References  Fanciulli et al., E J Neurol; 20 (2):  Ritz et al., Ann Neurol; 67 (5):  Chan et al., Nature; 447 (7148):
11 C8 External Globus Pallidus and pontine nuclei are involved in RSBD in Dementia with Lewy bodies: a DAT/SERT statistical parametric mapping 123 I-FP-CIT-SPECT study Daniele Liuzzi, P. Taurisano, F. Roselli, M. Pennelli, B. Tartaglione, M.F. De Caro, A. Bertolino, P. Livrea, A. Niccoli-Asabella, G. Rubini, G. Defazio Dipartimento di Scienze Mediche di Base, Neuroscienze ed Organi di Senso, Università degli Studi di Bari, Bari Background: REM sleep behavior disorder (RBD) is a prominent feature of synucleinopathies and a major diagnostic item for Dementia with Lewy Bodies (DLB). In Parkinson s disease and in DLB, the presence of RBD is thought to highlight a distinct subgroup of patients. However, the differences and the markers between patients with or without RBD are poorly investigated. Furthermore, the neurochemistry of the circuitry responsible for RSBD has not fully elucidated. Methods: Twenty-one DLB patients (8 with RBD, 13 without RBD) underwent brain SPECT with the DAT and SERT specific radiotracer 123 I-FP-CIT. The scans of the two groups were contrasted with Statistical Parametric Mapping to study DAT and SERT-rich brain structures. Results: DLB patients with RBD displayed decreased DAT levels in external part of Globus Pallidus (GPe k=81, Z=3.93, p=0.027 FWE corrected; x -20, y -10, z 4); among SERT-rich structures, DLB patients with RBD displayed reduced uptake in a large cluster located in the pons (k=156, Z=2.59, p=0.005; x 8 y -24 z -40) and in a smaller cluster in the right anterior thalamus (k=10, Z=3.93, p=0.005 FWE corrected; x -19 y -14 z 1). Conclusion: Our data support the identification of DLB with RSBD as a possible DLB subgroup with a distinct patter of degeneration of dopaminergic fibers and more severe degeneration of serotoninergic neurons; our findings provide a tentative in vivo marker for the subgroups and provide evidence for the involvement of dopaminergic and serotoninergic inputs in the onset of RBD.
12 C9 Role of the polymyography versus a standardized treatment algorithm for management of cervical dystonia with botulinum toxin type A Roberto Erro 1,2, K.P. Bhatia 1, C. Cordivari 2 1 Sobell Department of Motor Neuroscience and Movement Disorders, University College London (UCL) Institute of Neurology, London, United Kingdom 2 Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom Background: Botulinum toxin (BoNT) injections are the first line option for the treatment of cervical dystonia (CD), however there is no consensus or guidelines guiding the muscles selection. Clinical features such as main vector of the abnormal posture and presence of muscular hypertrophy correctly drive the selection of muscles to be injected with BoNT in the majority of cases. However, a significant minority of patients, ranging between 15% and 25%, have suboptimal or no response to BoNT injections. To investigate the value of polymyography (pemg) in comparison to a recently proposed standardized algorithm for management of CD, we performed a retrospective analysis of CD patients with an unsatisfactory response to BoNT treatment referred to our service for a pemg. Methods: Thirty-eight consecutive patients with idiopathic CD referred to our service because of unsatisfactory response to BoNT were included in the current study. All patients underwent a video-multichannel EMG recording at least 4 months after their last treatment with BoNT. Video were recollected and severity of symptoms assessed using the Tsui scale during the rest condition. This allowed to identify the muscles to inject according to the treatment algorithm and these sets of suggested injections were compared to those driven by the pemg findings. Results: Following the standardized algorithm, none of our patients would have been properly injected. In fact, at least one muscle would have been wrongly injected in all patients and at least one muscle would have been missed in 63.6% of our patient. All of our patients had a positive response to the BoNT injections driven by the pemg findings. Conclusion: Here we show that pemg can lead to a significant change of muscular targets to inject with BoNT compared to a standardized protocol for management of CD patients. This may have a beneficial effect on treatment response in CD patients who are apparently unresponsive to BoNT injections. Inadequate muscle selection is probably the most common cause for treatment failure and we recommend the use of pemg to improve BoNT response in such CD cases.
13 C10 Substantia nigra hyperechogenicity in essential tremor: a possible link with Parkinson s disease Francesco Ripandelli, G. Cardaioli, N. Tambasco, E. Luchetti, E. Marsili, E. Sacchini, A. Gallina, S. Simoni, E. Brahimi, P. Nigro, A. Rossi, P. Calabresi Clinica Neurologica, Facoltà di Medicina e Chirurgia, Università degli Studi di Perugia - Azienda Ospedaliera di Perugia, Ospedale S. Maria della Misericordia, S. Andrea delle Fratte, Perugia Introduction: Lack of specific diagnostic markers makes uneasy and uncertain the distinction between ET and PD. The two disorders several times overlap in their clinical expression, with ET preceding PD onset . Transcranial Sonography (TCS) has been shown as a valid, noninvasive, widely available, real-time dynamic and high-resolution diagnostic tool to identify early an idiopathic PD . Objective: We aimed to investigate the prospective meaning of hyperechogenicity of Substantia Nigra (SN) in ET patients. Methods: 138 patients (79 PD, 59 ET) and 50 matched controls underwent TCS examination. All patients were followed in a prospective longitudinal assessment for at least three years. The sonographer and the clinicians were blinded to the results of each other. Results: 10 subjects were excluded from the analysis due to the bilateral absence of temporal acoustic window. In PD group, SN echogenicity mean values at TCS examination showed no correlation with disease duration, H&Y and UPDRS III score (Spearman, p>0,05). During the follow-up period 21 out of 59 ET patients revealed new onset parkinsonian symptoms or signs. This subgroup of ET patients (ET-PD) showed mean TCS values significantly different from the rest part of ET group without parkinsonian features (post-hoc analysis, p0,05). Conclusion: ET and SN hyperechogenicity, especially when present together, seem to increase the risk of developing PD later. References  Berg D et al. Transcranial Sonography in Movement Disorders. International Review of Neurobiology 2010  Fekete R & Jankovic J Revisiting the Relationship Between Essential Tremor and Parkinson s Disease. Movement Disorders 2011
14 C11 Pisa syndrome in Parkinson s disease: demographic and clinical correlations in a multicenter italian study M. Tinazzi 1, Ina Juergenson 1, F. Bombieri 2, F. Schena 2, S. Ottaviani 3, T. Bovi 3, G. Bisoffi 4, C. Uniati 4, M. Canesi 5, G. Pezzoli 5, R. Ceravolo 6, D. Frosini 6, S. Rossi 7, M. Ulivelli 7, A. Thomas 8, R. Di Giacomo 8, G. Fabbrini 9, M. Sarchioto 9, A.R. Bentivoglio 10, F. Bove 10, F. Tamma 11, V. Lucchese 11, G. Cossu 12, F. Di Stefano 13, A. Pisani 14, G. Amadeo 14, N. Modugno 15, F. Lena 15, M. Zappia 16, L. Raciti 16, A. Nicoletti 16, M.A. Volonté 17, F. Spagnolo 17, C. Dallocchio 18, M. Sciarretta 18, T. Altavilla 19, G. Abbruzzese 20, C. Cordano 20, C. Pacchetti 21, N.G. Pozzi 21, R. Marconi 22, S. Gallerini 22, A. Mignarri 22, R. Allocca 23, G. Defazio 24, F. Morgante 25, L. Ricciardi 25, A. Cannas 26, P. Solla 26, C. Vitale 27, A. Fasano 28, P. Barone 29 1 Department of Neurological, Neuropsychological, Morphological and Motor Sciences, University of Verona,Verona 2 Department of Neuroscience and Kinesiology, University of Verona,Verona 3 Department of Neurology, Azienda Ospedaliera Universitaria Integrata,Verona 4 Ufficio Supporto alla Ricerca e Biostatistica, Azienda Ospedaliera Universitaria Integrata,Verona 5 Centro Parkinson e disordini movimento, UVA CTO Milano, Milano 6 Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Pisa 7 Policlinico le Scotte, University of Siena, Siena 8 Università Chieti-Pescara, University Foundation Aging Research Center Behavioural Neurology and Movement Disorders Unit, Chieti 9 Dipartimento di Neurologia e Psichiatria, Sapienza Università di Roma, Roma 10 Istituto di Neurologia, Università Cattolica del Sacro Cuore, Roma 11 UOC Neurologia, Ospedale Generale Regionale "F. Miulli", Acquaviva delle Fonti (BA) 12 Dept of Neurology AOB Brotzu, Cagliari 13 Dept of Neurology University of Cagliari, Cagliari 14 Clinica Neurologica, Dipartimento di Medicina dei sistemi, Università di Roma Tor Vergata, Roma 15 IRCCS INM NEUROMED, Pozzilli (IS) 16 Dipartimento di Neurologia, Università di Catania, Catania 17 Dipartimento di Neurologia e Clinica Neurofisiologica, IRCCS Ospedale San Raffaele, Milano 18 U.O. Neurologia, Ospedale Civile, A.O. Pavia, Voghera 19 Servizio di Neurologia e Neurofisiologia, Istituto Clinico Beato Matteo, Vigevano 20 Clinica Neurologica 2, Università di Genova, Genova 21 Unità Operativa Parkinson e Disordini del Movimento, Fondazione Istituto Neurologico Nazionale "C. Mondino", IRCCS, Pavia 22 UO Neurologia, Ospedale Misericordia, Grosseto 23 Università degli Studi di Napoli Federico II, Napoli 24 Dipartimento di Scienze Mediche di Base, Neuroscienze e Organi di Senso, Università di Bari, Bari 25 Dipartimento di Neuroscienze, Università di Messina, Messina 26 Clinica Neurologica, AOU Cagliari, Cagliari 27 Università degli Studi di Napoli Parthenope, Idc Hermitage Capodimonte, Napoli 28 Division of Neurology, Movement Disorders Center, TWH, UHN, University of Toronto, Toronto, Canada 29 Centro per le Malattie Neurodegenerative, Università degli Studi di Salerno, Salerno../..
15 C11 (segue) Idiopathic (i.e. not induced by neuroleptics) Pisa syndrome (PS) in Parkinson s disease (PD) is a rare and controversial entity with only sporadic single case descriptions and only one case series . Therefore, its pathophysiology has been poorly investigated [2, 3]. We performed this multicenter cross-sectional study with the aims to estimate the proportion of patients developing PS in a large cohort of patients with PD and to assess relationships between PS and demographic/clinical variables. Patients with PD were selected from consecutive outpatients attending the participating centres. Patients treated with dopamine receptor blocking agents 6 months before the recruitment and patients with diseases of the vertebral column were excluded from the study. Age, sex, age at PD onset, UPDRS III and IV, PDQ8, antiparkinsonian therapy and any information on any lateral trunk flexion present at the time of the study were recorded. A total of 1123 patients (F:M = 503:620) with PD met the eligibility criteria and were entered into the study. Mean age and mean duration of parkinsonian motor symptoms were 69.2 (SD 9.4) and 8.1 (SD 5.2) years, respectively. Mean UPDRS III score was 21.9 (SD 10.9), Hoen and Yahr (H-Y) was 2.2 (0.7) and PDQ 8 was 7.5 (5.4). PS was detected in 103 out of 1123 patients (9.2%). The mean degree of lateral flexion of the trunk was 15.6 (SD 7.8). Lateral flexion of the trunk was towards the right and the left side in 70 and 33 patients, respectively. The leaning side was contralateral to the side of PD onset in 40 of the 85 cases with identifiable motor asymmetry at onset. Concomitant camptocormia was detected in 63 out of 103 patients with PS while antecollis in 27. Patients with PS were significantly older, had longer duration of disease and of treatment with antiparkinsonian drugs than patients without PS; the UPDRS III and IV, H-Y were significantly higher in patients with PS. These preliminary results suggest that PS is a relatively frequent and often disabling complication in PD especially in the middle and advanced phase of disease. References  Bonnani L., Thomas A., Varanese S. et al. Botulinum toxin treatment of lateral axial dystonia in Parkinsonism. Mov. Disorders 2007; 31; 22:  Di Matteo A., Fasano A., Squintani G. et al. Lateral trunk flexion in Parkinson s disease: EMG features disclose two different underlying pathophysiological mechanism. J Neurol 2011; 258:  Tinazzi M., Juergenson I., Vattemi G. et al. Pisa Syndrome in Parkinson s disease: an elctrophysiological and imaging study. J Neurol 2013

domain: health


Will progressive policies continue? It’s hard to tell.
North Korea has stepped up ICBM rhetoric this month
‘perpetually on the brink of further violence’
‘There is nothing we are afraid of’
Troops still not a big fan of social engineering.
This is unsettling
‘Torture is also counterproductive because it undermines our national security’
Gillibrand Denies That Mattis' Opposition To Sex Assault Reform Has Anything To Do With Blocking Waiver
Gillibrand says she’s just focused on civilian control of the military
‘Most guards did not know weapons readiness conditions’
‘As an All-Volunteer Force, DoD must be able to draw from 100 percent of America’s population’
It’s the third most expensive weapons program ever
A new version of the famous M2 is on the way
‘The error was an error on the part of the government’
‘It’s more difficult for me to reassure our friends and deter Iran’
‘So, if it gets rolled back, you’re weakening the United States military’
This adds $450 million to the $920 million contract last year.
It started as a complete accident
‘She has the utmost respect for General James Mattis’
‘We simply cannot afford to waste our precious defense dollars’