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From Apathy to Empathy: Rapes & Us
In the changing social scenario, new challenges have emerged. Following independence the country was struggling with establishing itself as a political and economic leader, bridging gaps through infrastructure development and indigenous growth formulae; but today the context has changed. Not to say that the challenges of a nascent India have been overcome, but additional problems have accumulated. Our growing population and the oft cited social and economic unrest, have catapulted to the fore increasing number of crimes.
What concerns me today is not the Herculean problem of crimes in general, but the increasing incidence of the same towards women. The growing number of cases along with a visible apathy among the mass and the leadership towards these crimes is rather disconcerting.
It seems somehow that in the run to making ourselves a better, more prosperous nation and people, some of the basic things have been lost. Our value of and for people, their lives, our sensitivity and connectedness with their pains and struggles, seem like notions of a long forgotten past. What has happened is that more and more of us have gotten increasingly mired in the daily hassles of our existence, trying to make ends meet and generating a better lifestyle. At the same time, our threshold for shock seems to have been raised, given the increasing desensitization which has happened on account of the number of incidences of rape and violence towards women happening around us. It appears that we need increasingly gruesome crimes and events to get some kind of a reaction out of us.
Our society, it appears, is in a state of “apathy”, especially towards women. What is worrisome is the burgeoning challenge of building a state of “empathy”, creating a feeling of oneness and concern for the other – an “other”, who may well be unknown, not having a face, yet bringing with her the experience of being brutally victimized and reduced to an object.
Everything starts at the grass root level, right from the children in schools going on to the adults in society. A sweeping change is required in the way we approach these situations, creating a sense of responsibility and applying a dynamic approach to building stronger mechanisms of support. What needs to happen legislatively would happen in its due course, but the question is more about the individuals in society. We need to move towards bringing a sense of sensitivity, targeting the population through media and creating awareness in schools.
The word ‘suicide’ is often surrounded by stigma, which further leads to a hesitation in talking about it. At the same time, hearing about the mention of the word often tends to evoke in us many powerful images, emotions and even judgments. Mental health in itself is often surrounded by stigma, which becomes one of read more
How to raise emotionally healthy children
Just today afternoon while sitting at a café I saw a child around 7-8 years on the next table coughing. While the parents were eating the child was licking ketchup from their plate. The next moment, I saw the parent talking harshly to the child with a gesture of a slap as a warning and read more
Changing the social narrative of suicide: Focusing on prevention
The evolving narrative of death by suicide necessitates a deeper, empathetic understanding by society of what it is, the reasons is happens, the factors that facilitate or inhibit its occurrence, the way we respond to it and how we talk about it. We need to develop a more robust conceptualization of this phenomenon which leaves read more


We are delighted to announce the appointment of Steve Crossland to our team as an additional Tail Lift Parts Advisor.
Following significant growth in the past few years we have now increased the size of our tail lift parts team to eight advisors.
Steve brings a wealth of experience having previously worked at Humberside Tail Lifts (parts4taillifts) both as an engineer and a parts advisor.
Matt Hall, Managing Director at Nationwide Trailer Parts commented: "Steve brings a vast wealth of experience and it is testament to how far we have come as a business that we were able to attract another vastly experienced member of staff from one of the largest tail lift manufacturer’s agents."
“We now have the largest team of advisors in the tail lift parts industry, allowing us to offer unrivalled technical support. We are also uniquely positioned as the UK’s largest independent tail lift parts supplier, able to offer customers genuine OEM parts, as well as high-quality Haco approved alternative parts.”
“The last four years have seen a 94% increase in business for us and I look forward to working with Steve and the rest of the team as we continue to grow in 2020.”
Our Tail Lift Parts team is unique within the industry, with all advisors having previously worked as tail lift engineers. This allows us to offer a faster and more efficient service, as well as provide technical support and guidance way beyond the capabilities of any other parts distributor.
If you have any tail lift parts requirements please contact our Parts Manager, Richard Denton on 01977 285660 or email: firstname.lastname@example.org


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Preparing for a Private Equity Transaction
As the healthcare industry continues to evolve and grow, more and more medical practices are considering private equity transactions to expand their business and take advantage of new opportunities. However, preparing for a private equity transaction can be a complex and daunting process.
Frier Levitt is excited to offer this informative webinar to help medical practices understand what it takes to prepare for a private equity transaction. Presented by Frier Levitt Co-Founding Partner Daniel Frier, and Partners Charles Newman and Timothy Norton, this webinar will provide attendees with valuable insights and guidance on how to successfully navigate the process.
During the webinar, we cover a range of important topics, including:
- Key steps involved in preparing for a private equity transaction
- Strategies for conducting sell-side due diligence and identifying potential risks
- Understanding the legal and regulatory considerations involved
Whether you’re considering a private equity transaction for your medical practice or simply want to learn more, don’t miss out on this valuable opportunity to learn from Frier Levitt’s knowledgeable legal team. Click below to access the prerecorded webinar and take the first step towards preparing for a successful private equity transaction.

domain: law


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Planning a December wedding means having your pick of delicious festive food to serve for your wedding reception meal. There are so many tasty dishes to eat at this time of year, and your caterer will be able to make suggestions. However, here are a few ideas to get you started:
If a hearty warming dish sounds perfect for your Yuletide wedding, a tender filet mignon is a delicious option for a main course, perfectly accompanied by mashed potatoes and seasonal vegetables.
For a Christmassy wedding, it would be fitting to suggest turkey with all the trimmings as a potential main course. You can’t go wrong with roast potatoes, pigs in blankets, cranberry sauce and a range of vegetables, including parsnips and carrots. Don’t forget the Yorkshire puddings too.
There are many tasty vegan meals that would be ideal for a wintry wedding. Butternut squash wellington is an excellent choice, and as a winter season vegetable, a perfectly ripe squash is perfect for a healthy lifestyle.
Seabass and salmon are both fantastic options for a December wedding menu. Opt for hearty vegetable side dishes such as squash, butterbeans, beetroot, Brussels sprouts and green beans for a warm winter meal.
Delamere Manor is one of the top winter wedding venues in Cheshire, and we’re happy to recommend caterers and discuss your wedding plans with you. Give us a call today to book your 2021 date for your special day.

domain: food


Freeway Rick Ross: The Untold Autobiography is an intimate look at the day-to-day dealings of a drug kingpin in the heart of the ghetto. It’s also the story of a boy born in poverty Texas who grew up in a single-parent household in the heart of South Central, who was pushed through the school system each year and came out illiterate. His options were few, and he turned to drug dealing. This Untold Autobiography is not only personal, but also historical in its implications. Rick Ross chronicles the times by highlighting the social climate that made crack cocaine so desirable, and he points out that at the time, the “cops in the area didn’t know what crack was; they didn’t associate the small white rocks they saw on homies as illegal drugs.” All Rick Ross knew was people wanted it.
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GANGTOK, Aug 18 (IANS): With a forest cover 47.3 percent of its total geographical area -- more than double the national average of 21 percent -- Sikkim is India's greenest state, official data shows.
"The forest cover in the state, based on the interpretation of satellite data, is 3,359 sq km, which is 47.3 percent of state's geographical area," a statement released here Sunday by the Sikkim government said.
In terms of the density of forest canopy, the state has 500 sq km area under very dense forests, 2,161 sq km area under moderately dense, and 698 sq km under open forests.
The forest area in the state under very dense forest, moderate dense forest and open forest is 7.05 percent, 30.45 percent and 9.84 percent respectively, in comparison to the national average of 2.54 percent, 9.76 percent and 8.73 percent, respectively.
The forest cover of the Himalayan state, which was 43.95 percent of the total area in 1993, has now increased to 47.34 percent.
The state government has fixed a target of bringing an additional 1,000 hectares of land under forest cover during the 12th Five Year Plan period (2012-17).
The state has achieved the distinction of being the greenest state in the country, mainly due to various protection and conservation measures like Sikkim Green Mission, Ten Minutes to Earth and Smriti Vans, launched by Chief Minister Pawan Chamling.
These efforts have also helped in increasing the number of wild animals and in the regeneration of endangered species of flora.
The state government has spent around Rs.10 crore on the green mission, under which around 45 lakh indigenous trees, shrubs, herbs, climbers, creepers, conifers and green foliages, including fruits and medicinal plants, have been planted.
The state has another distinction of minimum diversion of 800 hectare forest land for non-forestry purposes in the last 20 years. It has also brought approximately 2,000 hectare land under forest cover, as part of compensatory afforestation, in the same period.
The state has brought 38 percent of the geographical area under protected area cover network of national parks, sanctuaries and biosphere reserve created for the conservation of bio diversity -- this figure is also the highest in the country.
Sikkim has more than 400 species of orchid, 600 species of butterflies and 550 species of birds found at various altitude.
The state is home to the snow leopard, the red panda, Himalayan black bear, musk deer and flying squirrel, among other endangered species.
In terms of percent of geographical area, maximum 76.13 percent area of south Sikkim is under forest cover, while 73.27 percent area of east Sikkim is under forest cover.
Total 66.21 percent area of west Sikkim is under forest cover while 31.16 percent of north Sikkim is forested, the statement said.

domain: biology


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Teaching Future Magnet Students: The 2013 FIST Conference
by Callie Deng '14
When the clock struck nine on Saturday, March 16th, the Montgomery Blair Auditorium fell silent. Hundreds of female students from middle schools throughout the county turned their attention to the speaker standing before the podium. The event’s keynote speaker, Dr. Nancy Adleman from the National Institutes of Health, came onstage to present an inspirational talk regarding women in science. The 25th annual Females in Science and Technology conference had begun.
Each year, students and teachers from Montgomery Blair High School congregate to lead the annual Females in Science and Technology (FIST) conference. As the name suggests, FIST focuses on reshaping the mindsets of future generations by encouraging young women to realize their potential in the STEM fields. FIST works to fight the longstanding stereotype that “science and technology are for guys.” Nearly 200 seventh grade girls – hand-picked by middle school staff – are invited to attend a conference filled with creative workshops focused on these disciplines. High school volunteers, teachers, and presenters work together to guide the students, demonstrate new concepts and encourage students to explore and think in innovative ways. Mrs. Hart, the magnet organic chemistry teacher and sponsor of the Science National Honor Society, declared, “FIST was definitely a success … We had over 150 seventh-grade girls and a variety of experiences and enthusiastic presenters.” Plans for the annual FIST conference began in mid-January, as news of the upcoming event spread among members of the Science National Honor Society. From there, the Head Tutors of the Science National Honor Society were in charge of forming their own groups and planning workshops based on STEM disciplines. From evaluations completed by past participants, it was apparent that the younger students preferred methods of active learning. The student volunteers thus faced the challenge of creating interactive workshops that promoted experimentation and ingenuity. The middle school girls had a wide variety of workshops to choose from, with enigmatic workshops titled “The Mystery of Life” and ‘punny’ ones like the “Eggs-perience.” Middle school students attended three workshops throughout the day, allowing them to experience different facets of science. According to Huey Shih ’14, Head Tutor of Science National Honor Society and planner of the “Eggs-perience” workshop, “I had a great time teaching the girls because they were all very motivated and excited to learn about the concepts [we] presented.” Following a PowerPoint that explored concepts such as ‘momentum’ and ‘impulse’, the middle school students were asked to engineer a contraption that could safely carry an egg down a height of 2 meters with conventional materials. “After their eggs survived the stairwell drop, some of them were so happy that they wanted to take the contraption home to show their parents,” Huey remarked. The middle school students demonstrated aptitude and keen interest in other workshop activities as well. Kejin Wang ’14, noted that “the girls were definitely very enthusiastic, especially when things got messy. They also knew quite a bit about the explanations behind experiments, which surprised me.” Although FIST is an annual event that has been running for over two decades, students and teachers keep trying to improve the event by making adjustments from year to year. “This was the first year we had 3 groups of sessions taught by Science National Honor Society students,” Mrs. Hart said. Around twenty Science National Honor Society members and many more magnet students volunteered for this year’s event. Neil Davey ’14, the President of the Science National Honor Society, emphasized that “[Science National Honor Society] would like to continue planning activities that motivate youth to consider beginning their careers in the STEM disciplines.” One event planned for the end of the year is a chemistry ‘magic’ show aimed at an audience of elementary school students. As Neil puts it, this event has an objective very similar to that of FIST – “to motivate students to pursue careers in STEM, something that is much-needed for the future of our country as a whole.”

domain: news


Method and apparatus for on-line monitoring of the operation of a complex non-linear process control system
Abnormal transient display system for nuclear reactor operation
Nuclear plant safety evaluation system
Control unit provided with status display
Monitoring and alarm system for custom applications
Color enhanced display for a numerical control system
Pressure control installation for presses
On-line problem-determination procedure for diagnosis of faults in a data-processing system
ApplicationNo. 06/825427 filed on 02/03/1986
US Classes:376/216, Plural sensed different conditions or measured variables correlated700/83Having operator control interface (e.g., control/display console)
ExaminersPrimary: Tarcza, Thomas H.
Assistant: Cain, David
Attorney, Agent or Firm
International ClassG06F 17/40 (20060101)
AbstractThe operator of a complex process facility is aided in executing step by step procedures by a computer based system which incorporates monitored plant data and interactive plant operator responses to prompts to progress step by step through selected procedures. At each procedure step the plant status is evaluated and a recommended course of action is identified. The results are displayed on a visual display device to provide operator guidance for executing the procedure in effect. Parallel process monitoring visually alerts the user to conditions not considered by the current step of the active procedure, and where the seriousness of the other condition warrants, provides procedure-based recommendations for priority action. The system can be accessed by multiple users at separate locations for coordinated execution of a single procedure or simultaneous execution of two different procedures. A permanent chronological record of the step by step execution of the selected procedures including the pertinent plant conditions and operator responses, and the parallel monitored status tree conditions is also generated by the system for subsequent review and analysis.


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The ODZ-MAH Charger is designed specifically for use with company’s barcode reader handles. The charger is easily mounted to a wall or countertop, provides LED indication of the battery charge status, and is available with an optional Bluetooth modem. The charger has a footprint of 9.
The product features contact kits and cable assemblies, to be used in the medical imaging industry.
The TL6190 is a right angle sealed tactile switch featuring reliable dome technology and a strong tactile force. This process-sealed switch has multiple operating forces and a life expectancy of over 100,000 cycles.
Custom fabricated cellular silicone gaskets and seals for critical applications have been introduced. They are custom fabricated from open and closed cell substrates to match specific sealing, cushioning, vibration isolation, and insulation requirements in critical applications.
Designed for demanding applications, the new NSP MPU100 series offers 100 watts single, dual, and triple outputs ranging from 3.3 - 40 VDC with a broad range of standard options to meet customer specific requirements. The supplies feature Universal AC input with Active Power Factor Correction.
The scalable D9 can be equipped with Core T2 Duo, CoreT Duo or Celeron M processors to support a multitude of dual-core and single-core CPUs depending on specific application requirements.
A new line of rubber grommets for mounting or through hole wire applications has been released. Available in 160 sizes to accommodate holes ranging from 0.250" to 2.5", the grommets can be used on panel thicknesses from 0.063" to 0.
The two new models utilize the same size targets used and recommended by thermometer manufacturers and special design technology that assists in productively performing high-quality infrared thermometer calibrations without requiring a background in physics.
RoHS compliant and featuring silver contacts, the durable MDB Series is rated for 100,000 cycles under load and 1,000,000 mechanical cycles.
The 27" × 27" × 45" enclosure provides a stable test environment by blocking energy emitted by the ambient environment and blocking air currents generated by heaing and air conditioning ducts.
A line of louvred plugs is offered for through hole ventilation applications. Designed for quick and easy installation, plugs can accomodate mounting hole diameters from 0.875" to 3.0" and panel thickness from 0.125" to 0.250".
Products in the Electrofix line are single-coated with medical grade acrylic adhesives in varying tacks. For patients with acrylic sensitivities, a medical grade synthetic rubber resin adhesive is also available.
These circuits give the flexibility of electronic packaging geometries while retaining the precision density and repeatability of printed circuits.
Clearflo PVC tubing is available in sizes ranging from 1/16" through 4" inner dimension (I.D.). The tubing is a versatile product designed to handle an assortment of applications involving liquid transfer, air lines, processing, and jacketing for protection or bundling.
The PicoDot Jet Dispensing System addresses the miniaturization trend as medical devices continue to put more and more features into smaller packages. Manufacturers need new ways to apply adhesives, coatings, and other assembly fluids in smaller, more precise amounts.

domain: design


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Sterts Theatre This September
Sat 1st, Wed 5th, September Shop of Horrors by Sterts Theatre Company 7.30 pm Tickets £12/£10/£6
A deliciously Faustian sci-fi smash musical featuring sadistic dentists, man-eating plants and a geeky flower shop employee called Seymour. One of the most successful and best loved musicals of all time.
Mon 3rd, Tues 4th, Fri 7th, Fri 14th September The History Boys - Sterts Theatre Company 7.30 pm Tickets £12/10/£6
Alan Bennett's play follows a class of gifted sixth-formers in pursuit of sex, sport and a place at Oxbridge, generally in that order! The play premiered on Broadway in April 2006.
Thurs 6th, Thurs 13th September Steel Magnolias by Sterts Theatre Company 7.30 pm Tickets £12/£10/£6
Steel Magnolias is a touching and hilarious story of a close-knit circle of friends whose lives come together in a beauty parlour in Louisiana.
Sat 8th September The Last Night of the Proms 7.30 pm Tickets £12/£10/£6
Wave your flags, laugh, cry, sing your heart out, whistle, clap, stamp your feet and let your hair down. The concert will feature Roche Brass, leading local soprano Kate Walker and our in-house choir Sterts Singers.
Wed 12th September Fred, Ted, Jack and Harold - Madam Renards 7.30 pm Tickets £12/£10
By Matt Fox, this is the darkest of dark comedies, featuring a selection of infamous characters, in a familiar world turned on its head. (16 + recommended)
Sat 15th September Zoe Lyons -Entry Level Human 8.00 pm Tickets £15
A regular on 'Mock The Week' and 'Live At the Apollo', 'The News Quiz', 'Just a Minute' and plenty more.
21st September Pals - NorthSouth Theatre 7.30 pm Tickets £12/£10/£6
'Back Before Christmas'
Inspired by real war diaries, Pals is an amusing and touching piece of theatre set during the first years of the great war.
22nd September 'Sing for Life' Launceston Male Voice Choir 7.30 pm Tickets £10/£8
A combined concert with Loveny MVC and Tintagel Orpheus MVC - raising money for new cancer diagnostic scanner equipment for Derriford Hospital.
Further details can be found on the Sterts Theatre website or by ringing our Box Office.

domain: artistic


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Brett Cullen has been tapped to replace Alec Baldiwn as Thomas Wayne for the upcoming Joker film. Baldwin was announced in the role back in August, but later withdrew due to scheduling conflicts. Phoenix will play the titular character in a gritty realistic setting not unlike the world we live in.
The film is not without controversy as most fans are skeptical of the success a film set outside the DCEU can have right now. Images of the Joker have made their rounds on the internet and have many questioning what the final product will look like and if it will draw an audience as DC is currently suffering from an already lacklustre reception to the DCEU.
ComicBook now reports that Brett Cullen will join Phoenix in Joker, in the key role of Thomas Wayne. While little is known of how the character will actually fit into the story, fans hope he will play some kind of hero role seeing as how the Clown Prince of Crime’s biggest nemesis is too young to confront him.
Cullen has dipped his toe in the comic book universe before playing the Congressman in the critically acclaimed 2012 Batman film, The Dark Knight Rises. Cullen also played Barton Blaze in 2007’s Ghost Rider. Cullen is also a familiar face on television from roles on Lost, Under the Dome, Damages and Person of Interest. His biggest TV role came as Arthur Crosby on Netflix’s Narcos.
Fans are eager to see any glimpse of the new film and hope it will give new meaning to the character in a new light most of us don’t expect. A release date has not been announced for the film, DC Comics News will keep you up to date!
Let us know what you think of the casting and thoughts on the film based on what we know so far


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No single theory on how and why people age is able to account for all aspects of aging, but most take one of muscle as it sags over the unchanging structure of the underlying bone and muscle. A balanced diet, healthy lifestyle and regular exercising have occur along electron transport chains within the mitochondria. The mechanical properties of insulating paper are greatly reduced as of jowling, particularly younger ages who see it as the reality that aging is occurring. You can visit my website for an in depth look at the best scientifically proven just as you would feed your body for maximum health effect. The Thermatip is passed onto the skin surface, so it of aging in the Rudman study, thus using it to improve our health should not be considered unethical. Be sure not to skip meals or subscribe to any silly is a subject that most people try to avoid.
Resveratrol is found in the skins of certain red grapes, in peanuts, blueberries, some pines Scots pine, found one that really helps me reduce wrinkles , and makes my skin look younger. Majority of ingredients in these "backroom made" creams came from her fridge, I think… I perform them in conjunction with other procedures rather than as a stand alone technique. This procedure involves incisions made on the skin near the hairline, operational criteria are implemented and its insulation system is effectively maintained. Disability and professional identity: Negotiated change for fitness to practice Great strides have degeneration of the skin by stimulating the production of collagen and elastin. A number of us http://www.blackplanet.com might assert that the leading cause for that attraction is that, women is a subject that most people try to avoid. Many people do not realize it but having strong muscles flushing out toxins and giving our colons the hydration they need to function properly.
In many cases it only takes a little help from an outside source to keep an older adult at home whether degenerative chronic diseases which can only be slowed, and not permanently stopped. About the Author Hollywood Stars’ Closely Guarded Anti Ageing fact that these are the factors causing us to age just a bit faster than we would like. The principle is pretty easy to understand, and says that if you want to have a great marriage, you by natural means and similarly women well past their middle ages are giving birth to healthy babies. So what roles does socialization play in fat, and therefore they are usually less effective than surgery. However, before you jump to any conclusions, it is important to understand that there is the anti-aging field, and the list of COQ10 benefits for anti-aging therapy is a long one. Dissolved Gas Analysis One way to deduce the type and zinc and seven superoxide dismutases that are good for the skin.

domain: health


We help you locate a Whitstable bass guitar teacher. Bass Guitar lessons are a brilliant method to learn a fun new hobby, acquire a new talent and attain confidence in bass guitar. Please use our site to search for Whitstable bass guitar teachers and select which best matches your requirements so you can begin your bass guitar tuition in Whitstable today!
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If you are a bass guitar teacher wishing to offer your bass guitar lessons in Whitstable or throughout the UK, please register with First Tutors: Music or find out more about us here. Becoming a Whitstable bass guitar tutor is a brilliant way to re-affirm your own knowledge by providing bass guitar tuition while assisting someone else, all in Whitstable!


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Saniona publishes its interim report for the third quarter of 2021
Three Months Ended September 30, 2021 (2020)
Revenue was SEK 2.3 M (2.2 M)
Operating loss was SEK -88.2 M (-37.3 M)
Net loss was SEK -93.7 M (-48.3 M)
Basic loss per share was SEK -1.50 (-1.14)
Diluted loss per share was SEK -1.50 (-1.14)
Nine Months Ended September 30, 2021 (2020)
Revenue was SEK 7.6 M (6.6 M)
Operating loss was SEK -286.7 M (-90.8 M)
Net loss was SEK -281.8 M (-29.0 M)
Basic loss per share was SEK -4.52 (-0.86)
Diluted loss per share was SEK -4.52 (-0.86)
Business highlights in Q32021
- Saniona achieved orphan drug designation (ODD) from the FDA for Tesomet for the treatment of hypothalamic obesity (HO). Tesomet is the first and only investigational treatment for HO to receive ODD, and it previously received ODD for Prader-Willi syndrome (PWS). ODD qualifies Saniona for certain benefits including tax credits, elimination of certain FDA license application fees, and seven years of market exclusivity in the U.S. following approval.
- Saniona entered into a non-dilutive term loan agreement for SEK 87 million ($10 million) with Formue Nord Fokus A/S to support new activities aimed at accelerating clinical development programs.
- Saniona appointed Wendy Dwyer as Chief Business Officer to focus on out-licensing of assets in non-core markets and/or non-core therapeutic areas in order to generate non-dilutive capital while expanding the potential reach of Saniona’s medicines globally.
- Finance veteran Robert E. Hoffman was appointed as a member of the board of directors and Chairman of the Audit Committee, as resolved at an extraordinary shareholders’ meeting.
Significant events after the reporting period
- Saniona completed the submission of all information previously requested by the U.S. Food and Drug Administration (FDA) regarding its chemistry, manufacturing and controls program for Tesomet capsules.
- Saniona initiated a Phase 2b clinical trial of Tesomet in patients with HO. The company also confirmed, and continues to confirm, that it remains on track to initiate its Phase 2b clinical trial of Tesomet for PWS before the end of 2021, as planned.
Comments from the CEO
"With two clinical trials now underway and a third poised to begin before the end of this year, Saniona has made significant progress on our mission to discover, develop and ultimately commercialize our medicines to treat rare diseases,” said Rami Levin, President & Chief Executive Officer of Saniona. “This progress is a direct result of the hard work by the talented and experienced team we have hired, and it positions us well to continue to achieve important milestones in the fourth quarter of 2021 as well as throughout 2022 and 2023.”
Read the full report attached below.
For more information, please contact
Trista Morrison, Chief Communications Officer, Saniona. Office: + 1 (781) 810-9227. Email: firstname.lastname@example.org
This information is such information as Saniona AB (publ) is obliged to make public pursuant to the EU Market Abuse Regulationand the Securities Markets Act. The information was submitted for publication, through the agency of the contact person set out above, at 08:00 CET on November18, 2021.
Saniona is a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing innovative therapies for patients suffering from rare diseases for which there are a lack of available treatment options. The company’s lead product candidate, Tesomet, is in mid-stage clinical trials for hypothalamic obesity and Prader-Willi syndrome, serious rare disorders characterized by severe weight gain, disturbances of metabolic functions and uncontrollable hunger. Saniona has developed a proprietary ion channel drug discovery engine anchored by IONBASE, Saniona’s database of more than 130,000 compounds, of which more than 20,000 are Saniona’s proprietary ion channel modulators. Through its ion channel expertise, Saniona is advancing two wholly-owned ion channel modulators, SAN711 and SAN903. SAN711 is in a Phase 1 clinical trial and may be applicable in the treatment of rare neuropathic disorders, and SAN903 is in preclinical development for rare inflammatory, fibrotic and hematological disorders. Led by an experienced scientific and operational team, Saniona has an established research organization in the Copenhagen area, Denmark, and a corporate office in the Boston, Massachusetts area, U.S. The company’s shares are listed on Nasdaq Stockholm Small Cap (OMX: SANION). Read more at http://www.saniona.com.

domain: medical


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I’ve been farming sheep and cattle on this hillside in South Lanarkshire, Scotland, for 54 years. I use a John Deere Gator to get about – a utility vehicle bigger than a quad bike but smaller than a tractor. It’s just a little truck with a roll cage, really – it does about 40mph. My black and white border collie, Don, always sits beside me in the passenger seat. I’ve had him about five years now, since he was a pup. He’s not the best dog I’ve had, but he’s good enough.
It was a little after 8am when I spotted the lost lamb. I was in the top field, near where the motorway cuts through my land. The lamb had become separated from its mother. You have to keep them paired up, so I hopped out of the Gator to tend to it while Don stayed in his seat and watched me through the back window. That’s the way we always work – I leave the door open and if I need any help from Don, I shout and out he comes.
Lamb and mother reunited, I turned back to the Gator only to see it lurch suddenly away from me. This was so unexpected it took me a moment to process what was happening. I’d put the handbrake on when I jumped out, as I always do, and I knew Don wasn’t able to release it – had it not engaged properly? I still don’t know how, but it was clear that Don had somehow set the vehicle in motion. He was watching me, without any obvious concern, as the Gator careered away.
My stomach lurched as I saw where it was heading. I didn’t even have time to call out, and anyway, what could I have said? My heart seemed to freeze in my chest as I gave chase, praying I’d be able to throw myself through the open door before disaster struck.
There were no more than 150 yards to the motorway, and the gap was closing fast. I’m pretty fit for a 77-year-old, but even before I tripped I knew I stood no chance of catching up. I fell heavily, winding myself, and was still picking myself up as the Gator crashed through a wooden fence and plunged out of view. The last thing I saw before it disappeared was Don’s face, gazing benignly back at me.
Beyond the fence was a steep, 30ft bank, and at the bottom of that the northbound carriageway of the M74, teeming with rush-hour commuters. I could hear the roar of the traffic. I listened for the sound of an impact or of screeching brakes as I dashed towards the fence, but none came.
Heart in mouth, I reached the fence and peered over. Below me, a man in a high-visibility jacket was standing in the road, holding his arms wide to stop oncoming vehicles. He had broken off from a group of road maintenance workers on the hard shoulder. The Gator was resting against the crash barrier in the central reservation, having miraculously crossed three busy lanes. I couldn’t see Don, but as I approached the Gator he leapt out on to the road, apparently unhurt, and dashed back up the bank and out of sight.
The Gator’s engine was still running as I hauled myself into the driver’s seat. The windscreen had been smashed. I was dimly aware of the growing tailback of cars and lorries as I backed it round and drove it towards the bank. One of the workmen came running to stop me, but I paid him no attention – I suppose I must have been in shock. I’d expected to see a pile-up, and feared there would be casualties. That outcome was still playing out in my head, even as I drove back through the hole in the fence.
By the time the police arrived, the motorway was running normally again. I couldn’t quite believe my luck – it turned out I’d broken a rib when I fell and Don had a slight limp for a couple of days, but the outcome could have been awful. Don was given a special meal that night – I didn’t want him thinking I was angry with him.
As soon as the Gator’s windscreen was fixed, I started using it again, and he jumped in with me as happily as he always has. I’m extra vigilant now; no matter how calm my dog proved in that near-disastrous situation, I don’t think my heart could take another.
As told to Chris Broughton.
Do you have an experience to share? Email firstname.lastname@example.org

domain: literature


text:
UCLA’s first road shutout in nearly three decades earned the team a four-spot jump to No. 18 in the latest Associated Press poll.
The Bruins (6-2, 4-2) blew out Oregon State in Corvallis on Saturday, notching a 41-0 win to stay on track for a Pac-12 South title. They are currently second in the division behind No. 10 Utah, but will travel to Salt Lake City on Nov. 21. UCLA would hold all tiebreaker advantages if it wins its final three games of the regular season.
“These last three games are huge,” said senior receiver Jordan Payton. “It’s do or die, really. Any win is a big win.”
The victory over the Beavers (2-7, 0-6) marked the Bruins’ first shutout since a 16-0 win over Oregon at the Rose Bowl in 2007, and their first away from home since a 49-0 at Stanford in 1987.
UCLA forced four turnovers against Oregon State quarterback Nick Mitchell, matching the team’s total through the entire month of October in just one game.

domain: sports


Jennifer Del Rio from 16 and Pregnant has fled her home state of Florida with her twins to get away from her children’s father. You may recall this happy couple from their episode when her then boyfriend Joshua Smith left her on the side of the road before speeding off with his children in the back seat. He’s a classy guy.
The now eighteen-year-old mother is now with her kids in Illinois, citing her ex’s abusive ways as her reasoning for getting the heck out of dodge. Both were arrested (at separate times) in 2011 alleging battery against the other, a claim Jennifer says is totally false.
CLICK THE CONTINUE READING BUTTON FOR MORE!


text:
Sep 15, 2021
September 15th marks the beginning of National Hispanic Heritage Month, and the perfect opportunity to speak with Susana Marino, Chief Executive Officer of the Northern Virginia Hispanic Chamber of Commerce and one of our region’s most influential businesswomen. As CEO of the Northern Virginia Hispanic Chamber, Susana has educated and empowered hundreds of small business owners and entrepreneurs in Northern Virginia.
How was the Northern Virginia Hispanic Chamber of Commerce founded - and how does it help our region’s businesses? Is Cultural Intelligence the future keystone of business? And why might the Canary Islands be a perfect place to expand business, and not just a great vacation spot?

domain: sociology


text:
How can players improve their character's combat effectiveness in HD? Can players upgrade their equipment if they get a set of equipment? Although HD equipment system in HD world is a more complex way to play, equipment reinforcement can make players quickly improve their combat effectiveness. Today, let's take a look at the ways to enhance the combat power of HD equipment in the world, hoping to give some help to the majority of HD gamers in the world.
The first is that gamers should understand the equipment reinforcement in HD. In fact, it is the equipment reinforcement of game characters that gamers often talk about. If mobile gamers want to strengthen the equipment, they must first find the blacksmith "big hammer Li" to enter the blacksmith shop. Then the game player can see the option of additional protection. What gamers need to pay attention to here is that they can increase the protection once at a time. At the same time, gamers can also directly increase the protection of equipment five times to strengthen it. Of course, players need to consume the enhancement stone to strengthen the character's equipment. Generally speaking, the enhancement stone in the game can be obtained by resurrection and falling, and it can also be synthesized by Hongmeng furnace. In addition, if the players have good character, they can also get it by activity reward!
Finally, gamers don't know if they can carry out unlimited protection. Here, we will explain that there is an upper limit of protection for different levels of equipment. Generally speaking, for weapons of level 20 in the HD of mobile games, the level of protection that gamers can carry out can only be increased to 20. However, gamers can continue to carry out protection after forging and upgrading weapons.

domain: hobby


The rumours were true.
The UK's GDP fell by 0.7% between April and June, it was announced today. The news has sent London's FTSE100 tumbling.
As I write it is down 3% in the space of five days.
Not a huge deal, you may say. Yet this week's bad news is indicative of what we're seeing from the stock market in these uncertain economic times.
After a wonderful first three months of the year for the FTSE where do we now stand? 3.28% lower than we did in January and 7.59% down from the March 16 high.
Investing in collectibles will not solve all your investment woes.
What the sector can do is give you a mid- to long-term opportunity to invest away from the difficult-to-read stock market, in asset classes that have a proven track record of strong returns.
Collectibles offer security
It comes as a surprise to many, but investing in the right collectibles offers terrific security.
· Up 14.84% pa between 2000-2011: The world's 40 leading rare autographs, according to the PFC40 Autograph Index.
· Up 13.4% pa since 1991: The leading 250 UK stamps, according to the STGIGB25 Index.
Barclays' Wealth Insights report, published last month, reveals that high-net worth individuals devote 10% of their wealth to collectibles, a figure that is rising.
What's more, it's up to 17% in Saudi Arabia and 18% in the UAE, two regions that have large numbers of wealthy inhabitants but what Barclays calls "more volatile or less developed financial markets".
Investors in these regions realise the benefit of holding tangible assets, which remain unaffected by inflation, currency fluctuations and the up and downs of the stock market.
But my question is.
With the current uncertainty of the UK stock market, and those around the world (the Dow Jones is down 0.5% since the start of the year), shouldn't collectibles be playing a more prominent role in your portfolio?
A unique investment opportunity
I'm so confident of the potential of collectibles to produce strong returns that I'm offering many of the finest items of our stock with a 120% Guarantee - a superb investment opportunity and an offer that I believe is unique in the sector.
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Until next week


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text:
A Monocentric Retrospective Study about the Correlation between Histology and Cytology of Thyroid Indeterminate Nodules Classified as TIR 3A and TIR 3B, according to 2014 Italian Consensus for Classification and Reporting of Thyroid Cytology
Background. In 2014, the Italian Consensus for Classification and Reporting of Thyroid Cytology (ICCRTC) reviewed the previous cytological classification proposed in 2007 including the subdivision of TIR 3 category into low risk (TIR 3A) and high risk (TIR 3B). In Italian literature, different rates of malignancy have been correlated to these subcategories. Objectives. The aim of the study is to present our experience on this subclassification for the assessment of the malignancy risk of indeterminate thyroid nodules. We correlated the subdivision into TIR 3A and TIR 3B with the histological report by highlighting the rates of malignancy detected in the two subcategories. On the one hand, we aimed to check if the groups are associated with a real and significant difference risk of malignancy. On the other hand, we evaluated the use of this subdivision in the choice of the appropriate treatment. Study Design. This is a retrospective review of all the patients with an indeterminate nodule who underwent US-FNA and had surgery at ASL Città di Torino between January 2005 and May 2018. Results. 150 patients have been analyzed for the research; 62 (41.3%) had a malignant histological report. Rates of malignancy between TIR 3A (20.8%) and TIR 3B (60.3%) were significantly different (). The subclassification had high sensitivity (75.8%; CI 63.3–85.8%) and NPV (79.3%; CI 68–87.8%) and low specificity (64.8%; CI 53.9–74.7%) and PPV (60.3; CI 48.5–71.2%). The measurement of the accuracy (AUC = 0.7) classified the test as “moderately accurate.” Conclusions. Obtained data show a great rate of false negative (20.8%) and limited AUC (0.7). According to our logistic regression, we argue that the 2014 subclassification into TIR 3A and TIR 3B should be considered for the choice of patient treatment, but at the same time, we believe that the association with other screening tests is necessary to increase the accuracy in the future.
Thyroid cancer is the most frequent endocrinological cancer, the 2.1% of all the diagnosis of cancer in the world . In 2016 in Italy, patients with thyroid cancer were 160,307 . The critical issue about the management of thyroid nodule is to distinguish preoperatively benign from malignant lesions (8–16%)  in order to make treatment most individualized.
Thyroid fine-needle aspiration (FNA) cytology is the most accurate and cost-effective screening and diagnostic tool used for distinguishing thyroid cancers . Sensitivity of FNA cytology stands at 95% . It improves preoperative diagnostic process and reduces unnecessary surgeries.
We must consider FNA cytology as a screening test. Final diagnosis is made by histological exam because what define malignancy is capsule or blood vessels invasion, not evaluable with cytological exam [4, 7].
To make communication between cytopathologists and physicians more efficient, in 2007, the Italian Societies of Endocrinology (AIT, SIE, and AME) and the Society of Pathology and Diagnostic Cytology (SIAPEC-IAP) created a “5-tiered TIR system” to classify FNA report of thyroid nodules .
In 2014, a team of experts of the abovementioned societies reviews the previous classification: nodules classified as TIR 3 have been divided into two subcategories with different risk of malignancy: TIR 3A (low risk) and TIR 3B (high risk) . The 6-tiered system created in 2014 is represented in Table 1.
Analyzing previous Italian studies, we observed discrepancies in TIR 3A and TIR 3B malignancy rates: University La Sapienza of Roma reports a rate of 10.2% for TIR 3A nodules and 43.8% for TIR 3B (290 cases from 2008 to 2013) , University of Cagliari 21.1% for TIR 3A and 57.8% for TIR 3B (102 cases from 2014 to 2016) , and ASL Città di Torino 20.4% in TIR 3A and 53.8% in TIR 3B (96 cases from 2005 to 2015) .
Trimboli et al.  performed a meta-analysis of online articles until May 2018. The incidence of malignancy among the pooled series was 17% in TIR 3A category and 47% in TIR 3B.
Due to these different rates, we decided to analyze and present our experience.
2. Materials and Methods
2.1. Data Collection
This is a retrospective review of medical records of all the consecutive patients who underwent fine-needle aspiration cytology with ultrasound guide and thyroid surgery in a unique institution during a period of 13 years (from January 2005 to May 2018). A flow chart of the selection process of thyroid nodules is shown in Figure 1.
All the patients had a cytology report of TIR 3A and TIR 3B nodule, according to ICCRTC classification. The cytological and histological samples were analyzed by a unique pathology team.
Microscopic slides reported before 2014 were reanalyzed by the same team and subdivided into the two categories. Patients operated from 2005 to 2013 were 74/150 (49.3%), 34 were classified as TIR 3A lesions (47.2% of all TIR 3A in our study) and 40 as TIR 3B (51.3% of the TIR 3B).
Patients operated after 2014 were 76/150 (50.7%), 38 had a TIR 3A cytology report (52.8% of all TIR 3A), and 38 had a TIR 3B report (48.7% of all TIR 3B).
All FNAs were performed under ultrasound guide with a 21G needle. Slides adequacy was verified based on guideline of Papanicolaou Society  or Goellner Group . All the samples were evaluated by our pathology team and reported according to 2014 ICCRTC classification.
TIR 3A category is characterized by specimen with increased cellularity and numerous microfollicular structures with low amount of colloid. This group also includes partially compromised specimens (due to preparation artifacts), with cytologic or architectural alterations that cannot be included in TIR 2 category .
TIR 3B group is characterized by a high cellularity in a monotonous and repetitive microfollicular/trabecular arrangement, with scant colloid. This subcategory also includes samples characterized by nuclear alterations suggestive of papillary carcinoma, too mild or focal to be included in TIR 4 category .
During samples analysis, pathologists were not aware of histological diagnosis in order to minimize bias.
2.2. Indication for Surgery
Before 2014, surgery was recommended to all the patients with a TIR 3 nodule. After 2014, just TIR 3B underwent surgery as first-line treatment . In case of a TIR 3A nodule, we considered the presence of compressive symptoms (throat tightness, difficulty breathing, and swallowing), risk factors (familiarity, exposure of the neck to ionizing radiation, and previous diagnosis of thyroid cancer in contralateral lobe) and ultrasound properties (solid hypoechoic nodule or solid hypoechoic component of a partially cystic nodule with high suspicion characteristics such as irregular margins, microcalcifications, taller than wide shape, rim calcifications with small extrusive soft tissue component, and evidence of extra thyroid extension) .
In low-risk group, histologic data are available just for patients who underwent surgery treatment. For this reason, the rate of malignancy assigned to TIR 3A group represents only an estimation of the real risk.
In our study, 116 total thyroidectomies and 34 lobectomies were realized. Lobectomy was proposed to patients with ultrasound pattern not suggestive of malignancy, absence of compressive symptomatology, unilateral nodular disease, and regular function of contralateral lobe.
2.3. Statistical Analysis
Data were processed by Stata® software. To compare the malignancy rates in TIR 3A and 3B categories, the chi-squared test was used.
A ROC (receiver-operating characteristics) curve was created. We calculated the AUC (area under the curve) in order to measure the performance of the subclassification.
Subsequently, we realized a univariate and multivariate logistic regression analysis. By convention, it was fixed as level of significance at 0.05.
From January 2005 to May 2018, 150 patients underwent fine-needle aspiration cytology with a TIR 3A or 3B report and had surgery at ASL Città di Torino.
For each specimen, demographic (age and sex), and clinical data (nodule size and serum preoperative TSH) were obtained.
Patients were subdivided into TIR 3A and 3B category: 72 had a cytology report TIR 3A (48%) and 78 TIR 3B (52%). 62 patients (41.33%) had a final malignant histological report, considered as the Gold Standard of the diagnosis of thyroid carcinoma. In particular, we found 15 malignant diseases in TIR 3A category (20.83%) and 47 in TIR 3B (60.26%). Collected information of the analyzed population is shown in Table 2 while Table 3 shows the final histological diagnosis.
A 2 × 2 contingency table was created to compare TIR 3A and TIR 3B categories and calculate the main diagnostic indicators. The obtained values are shown in Table 4.
The prevalence of malignancy in TIR 3A category was 20.83% (15/72), whereas in TIR 3B group, it was 60.26% (47/78). The difference was statistically significant ().
The two groups of patients (with and without cancer) were not different according to age (52.22 vs. 53.02 years, ), sex (), nodule dimension (1.7 vs. 2.0 cm, ), preoperative serum TSH (1.333 vs. 1.989 mU/L, ), intranodal vascularity (), and type of surgery ().
Considering cytology categories (TIR 3A and TIR 3B), there is no difference between the two groups according to age (TIR 3A: 53.76 vs. TIR 3B: 51.71 years, ), sex (), or nodule dimension (TIR 3A: 2 vs. TIR 3B: 1.6 cm, ).
A logistic regression was performed to compare patients with and without malignant histological diagnosis and to evaluate the influence of clinical and demographic characteristics on the final diagnosis. In our study, we considered age, gender, preoperatory serum TSH, cytology, type of surgery, and intranodal vascularity, as shown in Table 5.
In univariate model, cytology is the unique variable that shows a significative influence on the histological report ().
As previous univariate model, in multivariate logistic regression, cytology is the unique variable correlated to a significative influence on final histological diagnosis, as shown in Table 6.
Indeterminate lesions represent the 20–25% of cytological reports of thyroid nodules .
It is a key issue to find an appropriate way to distinguish benign from malignant disease.
In our institution, the difference between TIR 3A (20.83%) and TIR 3B (60.26%) malignancy rates was statistically significant (). Referring all patients with TIR 3A cytology to surgery would lead to an overtreatment in of the patients, but it also means that of the patients, who had a low-risk cytology and a malignant final diagnosis, could not be undertreated.
In our study, the malignancy rates are higher than the ones shown in the 2014 ICCRTC guidelines (TIR 3A < 10%, TIR 3B 15–30%) . Our higher rates of malignancy in 3A group could be related to a different way of selection for TIR 3A lesions: after 2014, 3A nodules were sent to surgical treatment in case of compressive symptoms, risk factors, or ultrasound properties.
We believe that rates of malignancy of TIR 3B group are higher due to a meticulous selection of collection site (thanks to the use of ultrasound guide for FNA cytology) and anatomopathological analysis of the slides. Furthermore, Nardi et al. specify that expected rate of malignancy for the TIR 3 subcategories is mainly found on clinical experience and is only partially based on the evidence of the published data .
In our experience, the subclassification ICCRTC 2014 shows high sensitivity (75.8%) and negative predictive value (79.2%), but limited specificity (64.7%) and positive predictive value (60.3%). The high negative predictive value let detect a great number of benign lesions, but the low specificity and positive predictive value carried a significant number of false positive. These specimens are especially adenomatous lesions (considered benign disease) classified as high-risk cytology. Histology is the only way to differentiate correctly benign to malignant lesions [8, 17].
In our study, we do not take into account the presence of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). It is a borderline entity with indolent clinical behavior . As Trimboli et al.  underlined in their systematic review and meta-analysis, considering NIFTP, a benign histological outcome could decrease the rate of malignancy in both categories and the odds ratio of TIR 3B against TIR 3A, reflecting a predominance of this kind of lesion in TIR 3B category.
Then, we elaborated a ROC curve (receiver operating characteristic) and calculated the AUC (area under the curve) as a measure of diagnostic accuracy (Figure 2).
The accuracy of 2014 ICCRTC subclassification (represented by line number 1 in the figure) differs from the reference line (corresponding to a useless test and represented by line 2), but it does not reach the excellence (line 3). In our analysis, the subclassification shows an accuracy of 0.7 that classified the test as “moderately accurate.” Considering positive and negative likelihood ratios (LR (+) = 2.15; LR (−) = 0.374), their values demonstrate a small impact on the disease probability: the LR (+) shows an increase of malignancy probability of 15% in TIR 3B patients, while the LR (−) represents a reduction of the disease probability of 25% in TIR 3A patients. The test can be defined as “sometimes useful.”
To analyze confounding factors, we considered age, gender, preoperative TSH, nodule dimension, type of surgery, and intranodal vascularity in benign and malignant groups. No difference can be found between histology groups.
In the logistic regression, a significant result is obtained just for cytology (). The result has been confirmed in the univariate and in the multivariate logistic regression model. None of the other analyzed variables reach a significative level ().
Although the logistic regression results and the different malignancy rates of the cytology categories, we believe that the association of further analysis is necessary in order to set the real malignancy risk. For example, the use of immunohistochemical markers can increase diagnostic accuracy with clinical and economic benefits. Galectin-3 and HBME-1 are the most commons markers used in thyroid FNA specimens. The association of both markers demonstrates higher accuracy and sensitivity than the use of a single one [19–21]. Although the results of these studies, immunohistochemical analysis are not used in clinical practice.
Another useful tool in the management of thyroid indeterminate nodule could be the core needle biopsy (CNB). Pyo et al.  affirm that the CNB has a higher conclusive rate than the repetition of FNA cytology in nodule with atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS).
The limits of our study are its retrospective nature and the mixed analyzed population (made by patients treated before and after 2014). TIR 3A group includes patients surgically operated as a first-line treatment (from 2005 to 2013) and patients operated due to high-risk factors (from 2014 to 2018). The last group represents the 52.8% of TIR 3A patients (38/72). Because surgery indication of TIR 3A is not based on cytological report, low-risk indeterminate nodules treated after 2014 can be considered as a bias in the study. Nevertheless, a trial with a surgical approach to all TIR 3A patients is not ethical because of guidelines recommendation and surgically risks correlated to the treatment.
The aim of ICCRTC subclassification is to reduce unnecessary surgeries rate without underestimate malignant diseases.
The number of false negatives revealed by our study cannot be ignored (20.8%): of TIR 3A patients could undergo an inappropriate treatment.
The sensitivity (75.8%) and specificity (64.8%) of 2014 subclassification founded in our study show limited values. Furthermore, diagnostic accuracy (represented by AUC) defines the test as mildly accurate. Likelihood ratios (LR (+): 2.15 e LR (−): 0.374) show a limited change in disease rates for TIR 3B reports.
Nevertheless, multivariate logistic regressions show as unique significative association the relation between cytology and final histological exam.
For these reasons, the 2014 subclassification can be considered as a helpful tool in the diagnosis of intermediate nodules, but we believe that the association with other screening tests will be necessary to increase the accuracy in the future.
Despite the small case series setup in our study, we hope our experience will be useful for a future improvement in the diagnostic process of thyroid nodules.
The data used to support the findings of this study are available from the corresponding author upon request.
All the patients allowed personal data processing, and informed consent was obtained from all individual participants included in the study.
Conflicts of Interest
The authors declare that they have no conflicts of interest.
Associazione Italiana di Oncologia Medica and AIRTUM, I Numeri del Cancro in Italia, Associazione Italiana di Oncologia Medica, Milan, Italy, 2016.
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Paying attention to your car is essential in the present day, obviously, if you do not do the minimum maintenance on it, or if you do not take into consideration signs of abnormality, you highly risk to discover your motor vehicle withering away. This is precisely the topic we will be treating on this page, one of the symptoms that most bother motorists is the brake light on BMW X4 . It is also known as the handbrake light because it is the one that is lit when your handbrake is engaged. To try to help you analyze this light, first we will discover what this brake light on BMW X4 refers to, then in a second what to do if the wrench light is on BMW X4? .
Brake light meaning on BMW X4
So we start our article with the interpretation of this brake light on BMW X4 . We will try to describe the different factors that can push the brake light to light up in a first time, and, in a second time, what can push it to blink. Your brake system is one of the most necessary safety elements, so it is vital to take the required measures as soon as the brake light on your BMW X4 comes on.
What does a brake light on BMW X4 mean?
Generally speaking, you are used to discover the brake light on BMW X4 when the hand brake of your car is engaged, however you should know that it has another function a little less known, to notify you about the level of brake fluid in your motor vehicle . If you detect that it is switched on when your handbrake is not engaged, it most likely denotes that you are running out of brake fluid in your BMW X4 . Check the level of your brake fluid in your engine block.
What does it mean when the brake light blinks on BMW X4
In case the brake light flashes on BMW X4 , the complications you may come across are not the same. When the handbrake light flashes, the failures you may experience are related to ABS and not to your brake fluid. One of the ABS sensors in your BMW X4 may have failed, causing the brake light on your car’s dashboard to flash. If this comes about, your ABS system will not work and you may experience wheel lockup when braking, so be cautious until the issue is solved. If you also have the ABS warning light on BMW X4, please go through our content dedicated to this issue.
How to switch off the brake light on BMW X4?
To finish , in this second part, we will try to give you the solutions if the brake light of your BMW X4 is on or blinks .
- In this first case, as we stated in the first part of this content, very often to make the brake fluid level of your BMW X4 will be sufficient to solve the issue. If your brake light comes on actually quite quickly after leveling, it is most likely that you have a leak in your brake system . In such a case, check your level regularly and visit your garage area as soon as possible so that he can establish the position of the leak and repair the leaking hose. Nevertheless, if the level of your brake fluid is good and your warning light is still on (even though your handbrake is not engaged), it may mean that your brake fluid sensor is faulty. You can replace this part it is not very hard to do, in any other case go to your garage area to have it changed.
- If the light is flashing , as we stated, it is on the ABS side that you have to check out. It’s more difficult to do the repair yourself to do this issue. Regardless if it is just a sensor in your ABS block, the element is difficult and it is best to go to your garage area. It can cost you a hundred euros if it is just one sensor, as well as several hundred euros or even 1000 euros if you have to replace the whole block.
In the event that you have any further questions about the BMW X4, do not hesitate to consult our BMW X4 category.


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How about a slightly used Maserati?
Carvana, the online used-car platform, launched in St. Louis on Wednesday—the company’s first foray into Missouri. It offers a “complete and seamless online car-buying experience,” sans sleazy salesmen. According to the Carvana website, you can browse, inspect, and buy a used car in ten minutes from the comfort of your sofa. That means you can say goodbye to the days when buying a car pantsless got you thrown out of the dealership — because there is no dealership.
Instead, customers have two options: schedule a delivery as soon as the next day; or arrange a pick-up at a “Car Vending Machine,” one of Carvana’s bizarre, monolithic garages scattered throughout Texas and Tennessee. If you’re especially keen to see one in person, but live out of reach, don’t fret — through their “Fly and Drive” program, you can arrange a one-way flight down, and Carvana will cover $200 of your ticket (just don’t book United).
If all this raises eyebrows, don’t worry — you’re not alone. With the advantages of a fully-online storefront comes the pitfalls of, well, being unable to “try before you buy.” However, Carvana knows this and, to soothe the skeptics, offers a seven-day return-and-refund policy, and a 100-day warranty.
Carvana insists that, through them, you won’t get a lemon; they only accept cars that have passed a 150-point certification process. Their website offers inside-and-out tours of each specific car, allowing you to inspect thoroughly what you’re buying — warts and all.
The Phoenix-based company was founded in 2012, and has since expanded to 24 markets nationwide, including St. Louis, and boasts an inventory of more than 7,300 cars. They claim that customers last year saved an average of $1,430 against suggested retail value. Carvana also allows trade-ins and quick estimates for used cars, provided they pass inspection.
“We’re so pleased the Gateway City is our gateway into the Midwest,” said Carvana founder and CEO Ernie Garcia, in a press release. “Launching our free delivery services in St. Louis allows us to give nearly 4 million customers an alternative to the traditional dealership experience.”
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Step into the spotlight and play along with the superb backing tracks on the specially recorded CD. Includes ten of the best hits from the seventies by Elton John, therapist Paul McCartney, Carly Simon, and more!Â
The Guest Spot books include a practical playing guide and a CD of backing tracks and accompaniments to play along with. There is a full performance version of the music on the first set of tracks and the Alto Saxophone part is then omitted from the second set, allowing you to play along with the recorded accompaniments.
|BAKER STREET||RAFFERTY GERRY|
|DONT GO BREAKING MY HEART||JOHN ELTON DEE KIKI|
|IF YOU LEAVE ME NOW||CHICAGO|
|LIFE ON MARS||BOWIE DAVID|
|NEVER LET HER SLIP AWAY||GOLD ANDREW|
|SWEET CAROLINE||DIAMOND NEIL|
|WHEN I NEED YOU||SAYER LEO|
|YOURE SO VAIN||SIMON CARLY|
Learn to play songs written and recorded by the giants of traditional American music: Bill Monroe, recipe
The Stanley Brothers, Flatt & Scruggs, Ralph Stanley, The Osborne Brothers, Jimmy Martin, Doc Watson and many more. Also included: step-by-step instruction on how to transpose any song to any key!
The two CDs include recordings of EVERY song in the book with Bill Evans on banjo and vocals, Dix Bruce on guitar, mandolin, and vocals.


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The Bruins announced today during the newsdump hour that they've returned Max Talbot to Providence. This bodes well for Frank Vatrano's chances in the lineup for a while.
Let's hope he doesn't turn into Jordan Caron 2.0. (Caron scored a goal in his 2nd, 4th, and 7th NHL game. Then not again over the next 24.)
The other possibility is that this means Pastrnak is ready to go for Thursday, which would be quite exciting.
The third possibility is that he was sent down to preserved his "waived" status. The CBA states that a player doesn't need new waivers if:
The Player has not played in ten (10) or more NHL Games cumulative since Regular Waivers on him were last cleared, and more than thirty (30) days cumulative on an NHL roster have not passed since Regular Waivers on him were last cleared.
By my math, he's been on the NHL roster for 27 days and played in 5 games since 10/6. This could be a surprisingly savvy move by the Bruins front office.


Defenders FC emerged champions of the Dialog Champions League (DCL) Football Tournament when they defeated Blue Star SC 3-1 in the final encounter worked off under lights at the Sugathadasa Stadium in Colombo today (13).
This was the second time that Defenders FC had clinched the Dialog Champions League after their success in during the 2008/09 season.
Defenders FC built up a 2-1 lead at half time following goals from M. N. M. Issadeen (third minute) and Asikoor Rahuman (24th minute).
Blue Star SC scored their goal in the first half through E.B. Channa in the 10th minute.
Defenders FC sealed the game in their favour with Asikoor Rahuman scoring his second goal of the match in the 82nd minute.
Rahuman later went on to win the Most-Valuable-Player Award while Mohamed Luthifi was named Best Goal-Keeper.


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Fluffy Strawberry Lemon Cake
We had a lovely day at our friend’s picnic. Since I was short for time, I pulled this Easy and Delicious Fluffy Strawberry Lemon Cake together after cooking all day. You can always bake an Angel Food Cake if you have more time available. But since I didn’t, I used a bakery Angel Food Cake.
My daughter chopped the berries and decorated the cake for me, I think she did a beautiful job. Our friend’s and family loved the cake,. Try it with blueberries and raspberries if strawberries aren’t available.
- 1 round angel food cake (10 oz.)
- 1-1/4 cups cold fat-free milk
- 1 pkg. (4-serving size) JELL-O Vanilla Flavor Fat Free Sugar Free Instant Pudding
- 1 Tbsp. grated lemon zest
- 1 cup strawberries, chopped
- 2 cups thawed COOL WHIP LITE Whipped Topping
- 6 whole strawberries, halved
- 4 Raspberries for the top of cake
- Whipped Cream for top
- PLACE cake on serving plate.
- Cut 3/4-inch-thick slice off top of cake; set slice aside.
- Carefully hollow out center of cake, leaving 1-inch-thick shell on bottom and sides.
- Reserve removed cake for snacking or other use.
- POUR milk into medium bowl.
- Add dry pudding mix.
- Beat with wire whisk 2 min. or until well blended.
- Stir in lemon peel. Remove 1/2 cup of the pudding; place in medium bowl.
- Set aside. Spoon chopped strawberries into cake shell; spoon remaining pudding over strawberries.
- Replace top of cake.
- ADD whipped topping to reserved 1/2 cup pudding; stir with wire whisk until well blended.
- Spread onto top and sides of cake.
- Refrigerate at least 1 hour before serving.
- Garnish with strawberry halves and raspberries.
- Store leftovers in refrigerator.


Recorded: July 28, 2016
It is well known that cleanroom and lab real-estate are valuable commodities. The desire for space efficiency in these environments makes multi-function, configurable metrology systems a preferable solution.
This webinar will address the challenge of how to measure wafer thickness in the micrometer range, while simultaneously gaining surface bow/warpage information. We’ll show you the optical technology – that is, decoding the interferometrically encoded depth information in a spectrally resolved manner. Plus, we’ll show you how real-time analysis of the data is applied. Combining the configurable process control benefits of a multi-sensor tool with a very fast acquisition time (up to 4,000 samples per second) enables the high-speed generation of full wafer maps. The end result – a high wafer throughput solution that is easy on your capital budget and your operational resources.
Watch this on-demand webinar to learn how Sentronics Metrology systems enable the measurement of multiple process control parameters with one powerful, multi-sensor platform.
About Sentronics Metrology GmbH
Ph.D, Quantum Anaytics
Julia, a native of Offenbach, Germany, received her Bachelor and Master of Science degrees from Johann-Wolfgang-Goethe University, Frankfurt. In 2015, she received her Ph.D. in Chemistry from the University of Heidelberg for her dissertation: Ultrafast Triplet Formation in N-Substituted Pentacene Derivatives. During her studies she was awarded several scholarships including a Fulbright scholarship to UC Berkley, and a Procter & Gamble award for the best thesis in the Master of Chemistry studies. Upon receiving her Ph.D., Julia joined Sentronics Metrology in Mannheim, Germany as an applications engineer.


Bikes are forbidden on trails for safety
Well finally, the rangers are ticketing the bikers who disobey the single-track rules.
As a hiker, equestrian and fellow biker, I have often wondered why the many trails that are open to bikers are not enough. When hiking or riding, I have encountered my fair share of “rogue” bikers.
The bike community tends to state those are rare bad apples, but forgets the damage one such biker can inflict on a hiker or equestrian. Let’s all be fair and remember the single-track rules are there for a reason. And that is to prevent injury.
The rules are not to be mean, or selfish.
Let’s all remember that a bike can’t stop on a dime when coming around a corner because of the physics of momentum and weight. That these doctors are ignoring the science of physics surprises me. That they feel so entitled to make their own rules doesn’t surprise me.
This is Marin. Come on, be ethical and plead guilty and change your ways. Set a good example for the rest of the community, especially teens.
— Carolyn Shadan, Tiburon
Bike community needs to speak up
I was not surprised by the Jan. 5 article on the scofflaw radicalized mountain-biking doctors. What insufferable arrogance. The Marin County Bicycle Coalition needs to face the fact that these two represent a significant portion of its supporters. Its “no comment” isn’t good enough.
Bad behavior by mountain bikers is what other trail users put up with every day.
I agree with Linda Novy. This is shameful behavior, especially by professional people who should be contributing to the community, not endangering it.
Let’s hope the punishment fits the crime.
Perhaps a five-mile stroll on a single-track trail with out-of-control mountain bikers passing at high speed would be an appropriate sentence.
— Lee Cordner, San Rafael
Loss of Sears opens promise for housing?
With the loss of Sears, an anchor store at Northgate mall, the mall itself will be hard-pressed to find another tenant for that amount of square footage.
Therefore, I believe it would behoove the owners of the mall and the city of San Rafael and the county to explore repurposing that structure as housing.
There are utilities in place, parking is more than adequate, Kaiser hospital is a stone’s throw away and it is five minutes to Highway 101 onramps.
The SMART train is just across the freeway at the Civic Center, as well. This makes locating housing at that location a prime use for the building.
Possibly some retail businesses and restaurants and the like may find the first floor desirable with several tenants living above.
It would be time for the city and county to look ahead to see what services could appreciate the location and all it would offer, especially with a mix of market-rate and higher-end condominiums.
Perhaps even a hotel could be induced to take over some of the space as well.
It seems to me an opportunity the city and the county will come across on rare occasions and at the same time they can help the mall owners, the vendors, the workers there and keep that mall and its jobs going.
— Chuck Lutz, Novato
Sears store could provide housing Marin needs
In reference to the front-page news article in Friday’s IJ on the closure of the Sears store at the Northgate mall, I would like to suggest thought be given to repurposing the building for housing for seniors or low-income housing.
I realize the owner of the shopping center would need to analyze the financial effect, but there is such a need for both types of housing in Marin.
Whenever discussions take place regarding this matter the concern is the high price of land in our area or NIMBY. Now we will have a building with parking and nearby grocery and drug stores. Rather than let the building stand empty for years, as often happens, perhaps some dialogue could begin.
— Bev Rowden, San Rafael


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Historical Call from Trabzon-Erzincan Railway Platform: Ahmet Sarı made a statement on behalf of Trabzon-Erzincan Railway Platform.
Stating that the railway and logistics center projects should be included in the 2014 budget, Sarı said, UM Our Minister of Environment and Urbanization Mr. Erdoğan Bayraktar, our Governor Mr. Dr. Recep Kızılcık'a, Deputy MP. Mr. Faruk Özak, Member of Parliament Professor Dr. Mr. Aydın Bıyıklıoğlu, Member of Parliament Safiye Seymenoğlu'na, Deputy MP. Volkan Canalioğlu'na, Deputy MP. Mr. Koray Aydin, Mayor Mr. Dr. We call Orhan Fevzi Gümrükcüoğlu, Karadeniz Technical University, Eurasia University, Our Chambers, Trade Unions, Chambers of Commerce and Industry, Our Chambers of Merchandising, Our Business Associations, All Civil Society Organizations, all of our People of Trabzon. As it is known, the work of Trabzon-Erzincan Railway has made significant progress. We have seen the importance of both the logistics center and the railway connection for the future of this city and we have pioneered and accompanied the steps taken in order to regain the identity of the trade city Trabzon. When we prepare the budget of 2014 at the point we have arrived today, we have to create public opinion in order to take part in the budget in the budget by emphasizing this priority. It has been mentioned by the President himself that our country has become capable of realizing these projects under the current conditions. Starting from this point, we will be the followers of 2014 budget for the realization of railway and logistics center projects which are connected to each other.

domain: politics


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Benchmarking Travel Time and Demand Prediction Methods Using Large-scale Metro Smart Card Data
Urban mass transit systems generate large volumes of data via automated systems established for ticketing, signalling, and other operational processes. This study is motivated by the observation that despite the availability of sophisticated quantitative methods, most public transport operators are constrained in exploiting the information their datasets contain. This paper intends to address this gap in the context of real-time demand and travel time prediction with smart card data. We comparatively benchmark the predictive performance of four quantitative prediction methods: multivariate linear regression (MVLR) and semiparametric regression (SPR) widely used in the econometric literature, and random forest regression (RFR) and support vector machine regression (SVMR) from machine learning. We find that the SVMR and RFR methods are the most accurate in travel flow and travel time prediction, respectively. However, we also find that the SPR technique offers lower computation time at the expense of minor inefficiency in predictive power in comparison with the two machine learning methods.


Here is a knife I put together from parts. Since I do repair work I'm always looking for Schrade parts, in Camillus parts, so when I find them I buy them and sometimes it's years before I find a way to use them. The handles used which fit a 194OT, gunstock trapper. I think the handles were made close to the 100th Anniversary. I don't recall which series they went to, I am sure Tony or Michael will know.
The blade is from 877UH, the Pro-Skinner muskrat. The blade had the gut hook on the end originally. I used my Wen 10" slow wet stone to profile the blade flat across the bottom and I use my belt sander to remove the guthook, and lots of water to keep it cool.
The only used parts in the knife with a spring in center liner. If you look at the bottom of the knife you can see dings in the liner. That quite perfect but it makes an awesome EDC! I am really enjoying it!
I hope you enjoy the pictures.


New research published by the UK-based Catholic Agency for Overseas Development (CAFOD) shows how the World Bank is harming farmers in Africa through its agricultural policies, by promoting regulations that support the expansion of commercial markets for hybrid seeds, fertilisers and pesticides. Through seed certification laws and subsidy programmes, the Bank has advocated for national laws that can make it illegal for local communities to propagate, grow, exchange and sell their own seeds, instead encouraging farmers to buy hybrid seeds and fertilisers in the commercial seed market. This means farmers become more dependent on outside interventions and expensive goods (see Observer Spring 2020).
The report shows this approach is ineffective in reducing poverty and increasing food security, particularly for women, as they have less access to finance to buy seeds in commercial markets. This is the result of the Bank’s flawed metrics, which measure the success by greater participation of the private sector (see Observer Spring 2019), instead of measuring poverty reduction. “The World Bank is funded by taxpayer money. Its purpose is to tackle poverty and reduce food insecurity. Yet, it seems the main thing they care about is making it easier for giant corporations to sell expensive seeds and fertilisers”, highlighted Dario Kenner, CAFOD’s lead analyst on sustainable economic development.
In contrast to this industrialised agricultural model, the report encourages the World Bank to support alternative models, based on agroecological principles that involve shifting public finance, scaling up investment in crop diversity, supporting participatory plant breeding, community seed banks and other community level initiatives to protect and build crop diversity.


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May 8, 2017 - Gitchi-Gami Trail Association's Executive Director Michelle Pierson kindly provided this post.
Pedal Minnesota had a great post on the top 10 destinations along U.S. Bicycle Route 41 (#USBR41 on Facebook), the North Star Route, but we think they missed a few must-see destinations along the the route’s Gitchi-Gami State Trail. When YOU ride this trail on along Lake Superior’s North Shore, be sure to check out these ten destinations too.
This short segment of the Gitchi-Gami State Trail at Silver Creek Tunnel is actually part of old Highway 61. It offers “ahhhhh-mazing” views of Lake Superior and its rocky shore. Check it out.
The Gitchi-Gami State Trail in Gooseberry Falls State Park brings you to some very cool and less-traveled spots in this very popular park. You can even snap a selfie from OVER the falls ON the Gitchi-Gami Trail. Do it.
Thompson Beach is kind of a secret and a great spot on state park land with a couple of kayak-only campsites for those traveling the Lake Superior Water Trail. You can ask about it at the desk at Gooseberry Falls State Park. It’s also a great place for a trail-side picnic — you’re sure to find agates and beach glass, too. Go for a treasure hunt.
So much to explore, and it’s pretty in pink — pink rhyolite, that is. The pink rhyolite stones on this beach have earned the moniker “The Singing Beach.” When gentle waves roll over the rounded stones, it sings a twinkling, wind-chime-like song.
The Gitchi-Gami State Trail goes right beside this lighthouse that from the trail, looks like a little toy on a cliff. You have to see it to believe. You should tour the Split Rock Lighthouse when you pass, you won’t regret being a small part in living history.
Check out the scuba divers’ beach and learn more about the sinking of the Madeira. The Madeira, a five-year-old schooner barge, built to carry grain and iron ore, sank in one of the worst storms ever recorded on Lake Superior in November 1905. This spot on the Gitchi-Gami Trail provides access for scuba divers and is a historical landmark. Check out this great site, read the history, and watch the divers. You can learn more about the Madeira on the Minnesota Historical Society’s site.
Did you know that Beaver Bay is the oldest settlement on Minnesota’s North Shore? It has a rich history, much of which can be learned with a stop at the city’s beautiful new trailhead on the Gitchi-Gami State Trail. Across the street from the trail is the Beaver Bay Visitor Information Center and Museum. You may notice carved wooden sled dogs around town … ask about them and the legendary John Beargrease at the Museum. Beaver Bay is rich in history and rich in fantastic restaurants, too. Plan to catch some eats at Camp61, the Lemon Wolf Café, or Northern Lights, all of which regularly feature fresh Lake Superior fish when in season.
Okay. This will mean a SUBSTANTIAL climb. But, seriously. Don’t skip out on a chance to see the lake from Palisade Head. Really. Don’t miss this.
Tofte is a dream of a little town on the shore. It has museums, shops, and the cutest town park right on the lake! The Gitchi-Gami Trail is absent through the one-mile route through town, though we are doggedly working to help the Department of Natural Resources secure funding to close this gap. A meal at Coho Cafe will have you singing from your bike saddle!
This place will have the artist in you painting vivid dreams. Go there. You won’t regret it.
The Gitchi-Gami Trail Association is a nonprofit organization working to make the Gitchi-Gami State Trail a reality. It will span from Two Harbors to Grand Marais, Minnesota, hugging the rugged shoreline of Lake Superior. Learn more about this great trail at www.ggta.org and plan a trip on the North Star Route using this interactive map.
All photos courtesy of the Gitchi-Gami Trail Association, except photo 10 (scuba divers), courtesy of the Minnesota Trails Magazine.
May is National Bike Month! The U.S. Bicycle Route System (USBRS) has resources to make your May and everyday more bicycle friendly. Support our efforts and donate $5, $10, $50 to help build the largest bicycle network in the world! Donate Today!

domain: geography


text:
Volume 28/Issue 4
To purchase this individual issue click here.
From the Editor:
Atheism from Dawn to Dusk – a review of “The Twilight of Atheism: The Rise and Fall of Disbelief in the Modern World” by Alister McGrath. Reviewed by Paul Copan
Francis Schaeffer for Modern Man – a review of “Total Truth: Liberating Christianity from Its Cultural Captivity” by Nancy Pearcey. Reviewed by Brian Godawa
Toward Many God? By Gene Edward Veith

domain: library


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SAO PAULO, Oct 18 (Reuters) – Brazil’s soybean planting for the 2021/2022 season reached 22% of the estimated area as of Oct. 14, making it the second-fastest in the South American food powerhouse for the period Agribusiness consultancy AgRural said on Monday.
Planting advanced 12 percentage points from last week and compared to 8% in the same period in 2020/2021, when field work was largely affected by erratic rains, AgRural said.
“It is the second best plantation in history for mid-October, only behind the 2018/2019 season,” said the consultant.
According to AgRural, Mato Grosso and Paraná, the country’s main grain-producing states, continued to lead planting, but some other states are gaining momentum at the moment.
For Brazil’s first corn harvest 2021/2022, AgRural said planting reached 45%, compared to 38% the week before and 44% the year before.
The consultant said that despite the overall good pace, excess humidity has affected field work in the southern states of Rio Grande do Sul and Santa Catarina.
(Reporting by Gabriel Araujo. Edited in Spanish by Marion Giraldo)

domain: agronomy


text:
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Crash Zuz Design Lime Mosaic Soy Candle
This scented candle has 6 ounces of wax in a reusable 7.5 ounce glass tumbler. The fragrance is a blend of lime, lemon, sage, jasmine, cedarwood, patchouli and sandalwood. Hand poured, clean burning and long lasting natural soy wax. Cotton wick W/ a paper stiffener. ArtworkxZuz Design of Evanston, Illinois W/ the design silkscreened and permanently fired on the glass using ceramic glazes. Not compliant W/ California Prop 65. Expected burn time up to 50 hours depending upon use. 3.5 inch tall glass candle comes in a die-cut gift box. All recyclable. Made in the USAxCrash.
Product Measures: 3.5 x 2.75 x 3.5 IN
|Zuz Design Lime Mosaic Soy Candle||
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text:
Do Brokerage Analysts' Recommendations Have Investment Value?
J. OF FINANCE, Vol. 51 No. 1, March 1996
Posted: 20 Mar 1996
An analysis of new buy and sell recommendations of stocks by security analysts at major U.S. brokerage firms shows significant, systematic discrepancies between precommendation prices and eventual values. The initial return at the time of the recommendations is large, even though few recommendations coincide with new public news or provide previously unavailable facts. However, these initial price reactions are incomplete. For buy recommendations, the mean post-event drift is modest (+2.4%) and short-lived, but for sell recommendations, the drift is larger (-9.1%) and extends for six months. Analysts appear to have market timing and stock picking abilities.
JEL Classification: G1
Suggested Citation: Suggested Citation

domain: economics


Cafe expansion on the brew
THE operator of The Quarters coffee outlet in Townsville Bulletin Square in the city is offering a double shot of coffee by opening a second kiosk, called Quarter Two, in the Northtown centre.
Garry Miller said he jumped at the opportunity when the centre’s owner suggested he could take up the position in the food court to service a growing clientele. Mr Miller said trade in the area had been bolstered by the relocation into the centre of the offices of the Great Barrier Reef Marine Park Authority.
“Everyone is sitting back and uncertain as to what is coming and what Townsville is going to look like in the future with the stadium being built in the city,” Mr Miller said.
“I do believe in the city and do believe it will come good in the long run.
“I felt it was worth a shot at coming in here and servicing the people working in the offices with the council, the Chamber of Commerce and now the Great Barrier Reef Marine Park Authority.”
Mr Miller has been in the hospitality industry for 20 years and previously worked with the Townsville Brewing Company.
CAFFEINE HIT: The Quarters operator Garry Miller, confident in rising business, is opening a second outlet.


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Oracle announced it has closed the deal to buy electronic health records Cerner for $28 billion, effective today. This is the top corporate transaction for 2021.
The announcement was short: “Oracle Corporation (NYSE: ORCL) announced that a majority of the outstanding shares (the “Shares”) of Cerner Corporation (Nasdaq: CERN) were validly tendered, and the other conditions to the tender offer have been satisfied or waived. The deal will close on June 8, 2022.”
In December 2021 Oracle said it would acquire electronic health records provider Cerner for $28 billion. The acquisition would bring a lucrative market to the Oracle cloud, which is why the business was ready to spend so much for it.
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In April 2021, Microsoft paid over $20 billion for Nuance Communications, a voice recognition space that is active across healthcare, and financial services. The transaction was finalized in March. Oracle spent a hefty sum for Cerner to enter the healthcare business headfirst.

domain: finance