New York, Sep 27: Asserting that the League of Arab States has been playing an important role in resolving the Syrian crisis, Foreign Secretary Ranjan Mathai said India fully supports the peaceful resolution of the conflict through a Syrian-led inclusive political process, based on firm rejection of any military intervention.
“The League of Arab States has been playing an important role in resolving the Syrian crisis. We fully support the peaceful resolution of the conflict through a Syrian-led inclusive political process, based on firm rejection of any military intervention,” said Mathai in his statement in the Security Council High-level Meeting on the situation in the Middle East.
“We urge all sides, Syrian and foreign, to cooperate with Joint Special Representative Lakhdhar Brahimi in good faith so that the Syrian crisis can be resolved without any further bloodshed,” he added.
Mathai said developments in West Asia and North Africa have played a major role in shaping the history of the world since ancient times.
“The region has been the birthplace of major religions of the world and of great civilizations. By virtue of the genius of its peoples, its strategic location and its natural resources, the region has been a focus of considerable interest internationally,” said Mathai.
“It is, therefore, not surprising that the momentous transformation in several countries of the region since late 2010 has been of great interest to the world at large. It has been a general aspiration that these transformations should be peaceful and lead to inclusive and democratic outcomes within these countries,” he added.
The Indian Foreign Secretary said the League of Arab States, as the most important regional organization predating the United Nations, has played a significant role in the unfolding of events in the region, and guided the involvement of the international community in these events.
“Chapter VIII of the UN Charter recognizes the importance of the regional organizations and their role in matters related to the maintenance of international peace and security. The Charter also provides a broad framework for this Council’s cooperation with the regional organizations, while clearly stating the primary responsibility of the Security Council for the maintenance of international peace and security,” he added.
Pointing out that the cooperation between the Arab League and the United Nations started in early 1950s, Mathai said both organizations have benefited from the convergence of objectives to maintain international peace and security, despite occasional differences.
“Enhanced partnership between UN agencies and the Arab League at institutional level in the fields of human development, capacity building, and empowerment of women and youth have been of great benefit for the countries of the region. There is a need now for further strengthening the existing cooperation to help the countries in the region in meeting the aspirations of their people for playing a greater role in shaping their destiny. India stands ready to cooperate in this regard,” he added.
Mathai said the objective of peaceful resolution of conflicts should determine the actions of the Security Council, and added that all UN activities, including its cooperation with regional organizations, should be consistent with the provisions of the UN Charter. “Both organizations should use all tools of diplomacy to assist the concerned countries in transiting to an inclusive and participatory polity while maintaining social stability and cohesion. The cooperation should encompass all relevant issues related to international peace and security, particularly the fight against terrorism,” said Mathai.
“The principles of national sovereignty, political independence, unity and territorial integrity must be respected. It is also important that peculiarities of each situation are kept in mind,” he added.
The Indian Foreign Secretary also pointed out that the Arab-Israeli conflict, including the Israeli-Palestinian issue, requires immediate attention of both the United Nations and the League of Arab States.
” This issue cannot be ignored while we focus on recent developments in the region. There can be no durable peace in West Asia without a just and comprehensive settlement, based on the realization by the Palestinian people of their inalienable right to a state of their own with internationally recognized borders, living side by side and in peace and security with Israel,” said Mathai.
“We, therefore, urge this Council as well as the Arab League to urgently facilitate the resumption of the Middle East Peace Process,” he added. (ANI)


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June 21, 2017
By Bill Wohnoutka
With the migration of applications from the corporate data center into the cloud well underway, traditional IP/VPN and dual data center perimeter-based security measures are becoming less effective. Increasing use of unsecured broadband and mobile devices by remote workers is accelerating the need for a new, more flexible security perimeter that can protect users regardless of how they access enterprise applications and assets.
SD-WAN solutions promise all the benefits of network orchestration by delivering ease of design, deployment and management for connecting remote locations to an IP/VPN — but the presence of premises-based x86 equipment perpetuates the need to manage a complex device potentially running four or five different virtualized functions and multiple “best of breed” vendors. Furthermore, these solutions do little or nothing to protect enterprise users of devices on mobile or broadband networks.
Network and security IT staffs run lean. We typically see one to two dedicated security employees in our midsize-to-large enterprise customer base. The budget to hire, train, retain and retrain a larger staff simply does not exist. Budget for hardware-based prevention and detection tools consume the largest share of the IT security budget. As IT budgets continue the transition from CapEx to OpEx – with capital preserved for more strategic investments – the pressure is on senior IT executives to find similar “pay as you go” and “expand as you go” solutions for security. Delivering against the governance, risk and compliance objectives remains the number one task for senior IT executives today, and that accountability brings these issues in front of the board of directors regularly.
While much has been said about the fear of compromised security in the cloud ecosystem, incorporating cloud-based security services into a multi-layered approach undoubtedly provides opportunities to protect users, devices and applications that simply could not be protected with a perimeter-based hardware security strategy.
1. A virtual security perimeter.
“By 2020, 85 percent of large enterprises will use a cloud access security broker (CASB) solution for their cloud services, which is up from less than 5 percent in 2015.”
– Gartner, How to Evaluate and Operate a Cloud Access Security Broker, Neil MacDonald and Craig Lawson, Dec. 8, 2015
In many cases, the only physical thing standing in front of network-security hardware in a remote location is a locked door. Migrating enterprise security controls from hardware located on premises into a cloud security service puts multi-layered physical security in place. More importantly, using a cloud-security service will enable you to define a virtual security perimeter that enables enterprise security controls to protect users and devices regardless of how or where they access hybrid cloud applications and assets. As BYOD becomes an increasingly important concern within compliance frameworks, this feature of a cloud-security solution should not be overlooked. Cloud-security controls give enterprises the ability to extend role-based and zone-based policies governing network access, content filtering and application control. They also extend monitoring visibility for behavioral anomalies that may be an indicator of compromise, such as communication with a C2, data leakage or malware delivery.
2. Simplified security infrastructure management.
“There will be an estimated 1 million cybersecurity job openings in 2016, with the number expected to increase to 1.5 million by 2019.”
— Forrester (May 10 2016)
Cloud-security solutions shift the burden of break/fix on hardware, patching and upgrading of operating system and security software, as well as maintenance of the enterprise security policies through the various orchestration tools and rule bases to the cloud-security provider. Thus, offloading running the security hardware and systems along with the obligation to react and respond to availability and performance issues presents a very compelling value proposition to an already overtasked but small staff. In addition, the forklift upgrades and infrastructure refreshes every three to five years transfer into the domain of the cloud-security provider, offering greater flexibility and buying leverage as the deployment, configuration and education are left to the providers. Moving enterprise security controls into the cloud frees up internal resources to focus on the development of a Security Event and Incident Management (SIEM) console and reaching the end goal of helping to ensure governance, reporting and compliance (GRC) across the enterprise.
3. Security expertise on staff.
“Hiring and retaining security practitioners, particularly analysts in the SOC, is difficult and expensive. According to our surveys, 58 percent of North American and European security decision-makers say hiring cybersecurity practitioners is a major challenge for them.
— Forrester (May 10 2016)
Adding security experts to an IT team is an expensive, time-consuming process, and qualified security analysts are very difficult to retain. Cloud security service providers have an opportunity to enlist the help of world-class security experts and supply them with industry-leading tools and training. Because they are monitoring an entire threat landscape, rather than a single network, cloud security providers are in a better position to bring the knowledge of their community of users to bear on identification of zero-day exploits as they are discovered in the wild. The economy of scale is at play in cloud security services; having a service provider that maintains the staff, multiple third-party threat/reputation feeds and a platform that can identify and correlate indicators of compromise is key.
Helping customers successfully navigate the digital security transformation will require the right skills and partnerships — but growth is off the charts. This report shows you how SDN and NFV impact the way networks are deployed, managed, consumed and secured. Download now!
Channel partners should assess their own capabilities and readiness to participate in the coming market shift. Premises-based hardware security has long been the domain of very specialized channel partners, but these new cloud-security services will favor providers who can bring a well-integrated combination of IP/VPN, SD-WAN and cloud security services side by side.
Bill Wohnoutka is vice president of sales, security solutions, for Level 3 Communications.
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I can see the nutritional benefits of feeding Exclusive Pet Food in the health and vitality of my own dog.
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After reading the label and seeing the quality ingredients, omega-3 content, and absence of artificial preservatives I tried this brand for my daughter's Corgis. Because we had a little of their previous "Cadillac-brand" still in the bag, my daughter mixed them and the Corgis sorted out the previous brand dropping those kibbles on the floor and only eating the PMI Exclusive! Their vote was clear.
Exclusive® Signature Chicken and Brown Rice Recipe
The food is moist and clearly full of oils, so no additional fish oil supplements are necessary. It smells like fish and my labs love it. Their coats look and feel like satin. Excellent food!
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I have been feeding this feed to my Horseback Field Trial dogs, with great success! Their energy and stamina have been awesome. At the end of an hour brace, there is still plenty of drive. The clean up in the kennel is quick and easy. I have fed several different feeds over the years and have found this to be superior.
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domain: pet


Smart Rural Transport Services
The project is further based on an ongoing project, Tomorrow's Letter Pigeons for good and close care - first in the countryside, which develops a fixed airline for light transport with drones in support of health care at a distance. Such a system is only a first, tiring step, as it is understood that it does not meet the entire transport needs of the care or the countryside.
In this project, we will therefore clear the boundary with a fixed line from point A to point B to address the needs that can be met with the service architecture in case drones can be sent to arbitrary addresses and positions.
The expanded service structure also includes future transports with self-driving electric vehicles, which are intended to be part of the same transport system as the self-flying drones. Vehicles and drones will both be part of the future transport system as care must be provided even in roadless land. The rural district medical center in Storuman has a special responsibility for Sami medicine.
Jan 2020 – Dec 2020
Region Västerbotten, KTH, LTH, Telenor, SVA, Iteam, Creed media group, Earhart AB, Einride, Lennox PR, Transtema, Mittmedia, Totalförsvarsstiftelsen
Pia Kristiansson, email@example.com


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“These events are so important to the work we do at Wilmot. They inspire us to keep making advances in cancer research and care every day. It’s incredible to see family and friends come together to celebrate their contribution to the fight against this disease,” says Tiffany Paine-Cirrincione, associate director, advancement and community events at Wilmot Cancer Institute.
Upcoming golf tournaments benefiting Wilmot Cancer Institute include:
- May 29: Sackett/Jeffords Memorial Golf Tournament held at Timber Ridge Golf Club in Brockport to support general cancer research in memory of Dave Sackett and Doug Jeffords. Learn more by emailing Tom Wagner at firstname.lastname@example.org.
- June 18: Mo Golf Tournament held at Cragie Brae Golf Club in Scottsville to support general cancer research in memory of Maureen Scantlin. Learn more by emailing Bob Scantlin at email@example.com.
- June 26: Fifth Annual KM Memorial Golf Tournament held at Victor Hills East Golf Club in Victor to support brain cancer research in memory of Kathleen Mrzywka. Learn more at kmmemorial.com.
- July 1: Ninth Annual Coop Cup held at Terry Hills Country Club in Batavia to support brain cancer research in memory of Clinton J. Cooper. Learn more on the Coop Cup for Cancer Research Facebook page at facebook.com/Coop-Cup-for-Cancer-Research-124807904204641.
- July 10: Fifth Annual For Pete’s Sake Golf Tournament held at Victor Hills Golf Club in Victor to support Dr. Aram Hezel’s research for bile duct cancer in memory of Pete Osterling. Learn more by emailing Kait Osterling at firstname.lastname@example.org.
- July 11: Seventh Annual Michael Contestabile Memorial Golf Tournament held at Deerfield Country Club in Brockport to benefit Dr. Aram Hezel’s research fund for pancreatic cancer in memory of Michael Contestabile. Learn more and get registration forms at facebook.com/events/1730792653810934.
- July 25: Edelman Gardner Ladies Golf Tournament held at Timber Ridge Golf Club in Brockport to support the Edelman Gardner Research Fund. Learn more at edelmancrf.com.
- Aug. 6: Kyle J. Button Memorial Golf Tournament held at Brae Burn Golf Course in Dansville to support the Ann and Carl Myers Cancer Center on the Noyes Memorial Hospital campus. The tournament is held in memory of Kyle Button. Learn more by emailing Jon Shay at email@example.com or calling (585) 370-0733.
- Aug. 15: Palmer/Head-Strong Golf Tournament held at Greystone Golf Club in Walworth to be split between research for non-smokers lung cancer and pancreatic cancer. Learn more at facebook.com/PalmerHeadStrongFoundation.
- Sept. 10: Fourteenth Annual Steve Coleman Memorial Golf Tournament held at Holley Creek Golf Course in Brockport to benefit the Wilmot Cancer Institute Research Fund. This event is held in memory of Steve Coleman. Learn more by emailing Laura Coleman at firstname.lastname@example.org.
- Sept. 12: Third Annual Ray Dutcher Jr. Memorial Golf Tournament held at Webster Golf Course in Webster to support brain cancer research in memory of Ray Dutcher. Learn more at facebook.com/RDJrGolfTournament.
Anyone in the community is invited to host a fundraiser – whether it’s golf or another type of event – to support cancer research and care in the Rochester and Finger Lakes region. Contact Tiffany Paine-Cirrincione at (585) 276-4715 or email@example.com to learn more.
UR Medicine’s Wilmot Cancer Institute is the Finger Lakes region’s leader for cancer care and research. As a component of Strong Memorial Hospital, Wilmot Cancer Institute provides specialty cancer care services at the University of Rochester Medical Center and a network of locations throughout the region. The Institute also includes a team of 100 scientists who investigate many aspects of cancer, with an emphasis on how best to provide precision cancer care. To learn more, visit .

domain: medical


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Zelda's Back, with a Message
Shortly after her father Robin's death, Zelda Williams decided to take a break from social media. When she left, she wasn't sure how long she'd be gone, but she did say that maybe it would be forever.
She'd had enough. While there were plenty of Robin's fans offering their thoughts and prayers to Zelda and her brothers, there were plenty more how had horrible things to say about the comedian and the manner of his death.
Yesterday, Zelda returned to Twitter and Tumblr. She quoted Harvey Fierstein - one of Robin's Mrs. Doubtfire co-stars - almost apologizing for letting the bullies win.
A powerful statement. And hopefully, a lesson learned for all of us...
Tags : People : Zelda Williams

domain: celebrity


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St. Cloud VA Health Care System
Veterans Virtual Town Hall Meeting Planned in St. Cloud
January 21, 2021
A Veterans town hall meeting focused on improving VA health care services and programs is scheduled on Feb. 9 at 2 p.m., via Webex, for Veterans served by the St. Cloud VA Medical Center.
The virtual town hall meeting provides Veterans the chance to hear from and have concerns addressed by St. Cloud VA officials while observing social distancing guidelines.
Webex is an online tool used for group meetings. For the Webex link to the meeting visit https://www.stcloud.va.gov.
Veterans may also dial in and listen to the town hall via the telephone by calling 1-404-397-1596 and entering 199 019 1707 when prompted on the day of the meeting.

domain: news


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Chhattisgarh Current Affairs - 2020
The Archaeological Survey team has recently claimed that a 500 year old temple that submerged in the waters of Mahanadi resurfaced.
The Mahanadi river that changed its course 150 years due to flooding had submerged the Padmabati village where the temple is located.
There are more than 22 villages in the region that are submerged in the waters of Mahanadi. However, Gopinath Deba Temple was visible as it is the tallest of all.
The temple is called “Mastaka”.
The Mastaka was visible 11 years back when the water levels were very low. The Mastaka was found while the Archaeological team of Indian National Trust for Art and Cultural Heritage (INTACH) was documenting the monuments along the course of river Mahanadi.
The Mastaka is the upper part of the temple. Only the Mastaka of the temple was visible.
The river flows through the states of Odisha and Chhattisgarh. The famous Hirakud dam is located across the river. The Hirakud dam is the largest earthen dam in the world.
Tags: Archaeological Sites • Chhattisgarh • Flood • Hirakud Dam • Mahanadi River
The Chhattisgarh Government recently launched Spandan Campaign. The campaign aimed to contain fratricide and suicide involving police personnel.
Under the campaign, the superintendents of police associated with the Chhattisgarh Government will start a parade in their districts every Friday. After the event, the grievances of the personnel are to be addressed. Also, the campaign has made medical treatment and counselling of depressed officers mandatory.
The campaign will also make arrangements for yoga classes for the police personnel at all the district head quarters. Cooperation of local yoga teachers have been sought to conduct these classes.
Also, the police officers have been instructed to the redress grievances of police personnel in regular intervals. The superintendents have been instructed to visit police stations regularly and make arrangements for recreational activities.
Around 50 police personnel in the state including paramilitary forces committed suicide in the state of Chhattisgarh in the last two years. Of these 18 were reported from seven districts that are affected by Maoists.
Also, in December 2019, around 6 ITBP personnel were killed at an incident of fratricide (killing of one’s brother or sister).


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Reading Level: Young Adult
Length: 288 pages
Publisher: Simon Pulse
Release Date: January 1, 2013
Stand Alone or Series: Stand Alone
Source: Borrowed from Library
Rating: 4/5 stars
I have been wanting to read this book a long time. I am not sure why except that the synopsis sounded completely intriguing to me. It ended up being a very interesting, introspective, raw and disturbing read.
Rudy is forced to move out to a desolate island with his family. Out at this island there is a type of fish that seems to be helping his young brother (who has cystic fibrosis) get better. While out there he meets a strange fish boy, and finds out that the miracle fish have a steep cost.
This was very well written and very atmospheric. The descriptions are both beautiful and horrible. The writing is a bit raw at times, there is a lot of swearing, and some gruesome imagery. The events that take place are never really described in detail but what the reader is left to assume is happening is very disturbing.
Rudy is a typical troublemaker sort of teen boy before he moves out onto this island. His main pastimes are smoking, drinking, and sleeping around. On the island though he feels like he is in purgatory, there is only one other girl on the island even close to his age and she won’t leave her house. Rudy starts drawing again, but his life mainly revolves around his brother’s health.
All that changes when Rudy meets Teeth. Teeth is a half fish, half boy (merman) of sorts who has a sad story and an even sadder existence. Teeth sees the special fish as his siblings and tries to protect them from the fishermen. When Ruby realizes this he is torn between having to choose between his brother’s recovery and his friendship/attraction to Teeth.
This is an interesting read about magic, loneliness, and what humans will do when they are desperate. Moskowitz assumes that readers are intelligent and doesn’t necessarily spell everything out for you. At times this makes the story kind of ambiguous. As a reader you pretty much know what’s going on but you kind of hope you are wrong.
There’s a lot of thought-provoking parts to the story where the question is raised about what is right. For example when is it right to sacrifice something to save something else? Aside from Teeth the magic in the story is very subtle.
The book is well written and engaging. It ties things up in a realistic, if not fully satisfying, way. It’s definitely not an uplifting story either.
Overall I enjoyed it and thought it was an intriguing read. It’s not a comfortable read and none of the characters are really all that likable. However it is an interesting read and explores some interesting issues. There is a lot of swearing and violence, so just beaware of that…probably best for older teens. The story is a bit disturbing and uncomfortable at points. Still it was different from a lot of other things I have read and I liked it.

domain: literature


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Omfg! I read the first three chapters of the InuYasha manga and was inspired to draw this! I love it.
I love you for this too.
this is awesome. i love how inuyasha's semi-interested in the butterflies
Thanks. That was the point. At first I just had him looking sideways like that, then I decided to add the butterflies. Partly for deco, partly because I like butterflies. :3
Omfg!I LOOOVE That show!!XDThe butterflys all"I'ma gonna land on yo ear dude."XD

domain: artistic


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Past Speed: 80 bpm Ι Length: 2:59 Min
Inspiring downtempo track with beautiful melody and emotional progression. The calm, peaceful song enhances sensations like astonishment or awe of something greater, not (yet) definable. It fits as background music for audio guides, exhibitions or presentations. The track equally serves themes such as retrospection and lessons from history, as well as innovation and visions of the future. In addition, it fits perfectly with the subject areas of esotericism and spirituality.


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More than 700 imams, gathered at a meeting sponsored by the Federation of Islamic Associations of Burkina Faso, have warned of the rise of religious intolerance in the country in the context of the upsurge in insecurity due to jihadist attacks in recent years.
“The Federation of Islamic Associations of Burkina Faso reaffirms its firm commitment and unconditional support for all initiatives aimed at repairing the social fabric and promoting dialogue; promoting national reconciliation and the return to coexistence; restoring the integrity of the national territory,” it has explained, as reported by the news portal Faso 7.
Burkina Faso is going through an unprecedented insecurity that undermines the foundations of its coexistence and its social cohesion. This security crisis has been fueled in recent years by hate speech and division on both sides, the meeting participants recalled.
“In Burkina Faso, there are more than 8,000 villages and in each village there is at least one imam who leads prayer five times a day in front of thousands of people. If these people convey the message, it can be productive for peace and social cohesion,” said the federation’s president, Musa Kuanda, as reported by the Sidwaya news portal.
Burkina Faso, led by a military junta since a coup in January this year, has generally been experiencing a significant increase in insecurity since 2015, which has led to a wave of internally displaced persons and refugees to other countries in the region.
The attacks, the work of both Al Qaeda and Islamic State affiliates in the region, have also contributed to an increase in inter-communal violence and has led to a flourishing of self-defense groups, to which the Burkinabe government has added ‘volunteers’ to assist in the fight against terrorism.

domain: sociology


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But as Miller points out, we don’t pray like Jesus prayed because we don’t believe that prayer makes much difference. The opposite of a childlike spirit is cynicism, and “cynicism is the air we breathe, and it is suffocating our hearts“. So Part 2 (of 5) addresses the problem of cynicism and how we can learn to trust again.
Yes, missionaries struggle with prayer, just like any other Christians. We are also tempted to do life without prayer, to treat prayer as a nice option, or even as something we feel obligated to do, rather than as our very life of communication with our heavenly Father.
The many illustrations throughout A Praying Life of how God taught Paul Miller about prayer through the challenges he faced in his own family, make this book an enjoyable and easy read. I also found Miller’s practical suggestions helpful, particularly as to how we can track our prayer requests in other ways that just going through a list of names.
Rather than giving a more extensive review of this excellent book, let me recommend a thorough and helpful review on Tim Challies’ blog. Paul Miller, the author even responds to the review in the comments at the bottom of the blog.
What books on prayer would you recommend to missionaries?

domain: library


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And when I say last minute I mean, packed my bags at midnight and was on my way early in the a.m.
No one - ......
Literally nobody - ....
Me - OMG I spent a totality of less than 2k on a 4 day trip to gokarna!!
It was around 4 a.m., we got off at gokarna station and took a taxi to kudle beach. We reached the beach, it was pitch black all around, we had no bookings and none of the beach shacks were open.
A perfect recipe for a panic attack!
We set our luggage down and waited for a miracle.
Happened to gaze upon the sky and poof! We instantly forgot all about the pickle we were in.
It was LIT! Quite literally.
Coldplay was right, it was a heavenly view. Being a Mumbaikar you could only imagine how excited that got us!
A short while later we had our rooms and at certain shacks you could even opt for tents.
Gokarna Street market Trek from one beach to another. ( Om beach, half moon beach, gokarna beach etc) Temple visits. (Mahabaleshwar temple) Shiva statue.
Stuffed our faces with delectable yet surprisingly cheap food. Built bonfires on the beach and sang and danced like fools. Went skinny dipping under the moonlight (j.k. we were fully clothed) Enjoyed the sight of bioluminescent plankton under the moonlight Slept on the beach and got sand in every possible body crevice, no regret! Best sleep ever!
Gokarna is indubitably the best budget beach vacay you need!
Nearest airport is Dabolim, Goa. You could take a taxi from there. There buses from Chatrapati Shivaji Terminus. We opted for trains. There are 2 direct trains from Mumbai to Gokarna, Maru Sagar exp. (12978) and Matsyagandha exp. (12619) with a minimum duration of about 10 hrs. You could always road trip it.
The best time to visit gokarnais from October untill March, when the weather is warm and pleasant.
Why rub off the red varnish off your toes after the dance? Aspiring Alchemist.
All picture are filter free.
Follow me on instagram - @v_nessassary for more <3

domain: geography


Muscle fit core line tee. 65% recycled cotton. Marled Blue
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— Update May 4th 2017–
I just found a couple of new releases that sounded so incredibly good that I had to share with you guys, and Until it Fades by K. A. Tucker that was supposed to come out this month got pushed back until June 26th — 😦 I hate when that happens, anyway, here are the books.
- The Knight – B. B. Reid
Little Mian Ross and the big, bad Knight didn’t find their fairytale ending. Together they found war.
Angeles Knight orders the liberation of Mian Ross.
He’ll tear down their enemies, forsake his throne, and give his life to keep her safe.
All Mian must do is forgive his betrayal and put her heart on the line.
How did I not know this was coming out this month???? What is wrong with me??? I love the firs book so, I’m jumping on his one pretty soon.
- DreamFall – Amy Plum
Cata Cordova suffers from such debilitating insomnia that she agreed to take part in an experimental new procedure. She thought things couldn’t get any worse…but she was terribly wrong.
Soon after the experiment begins, there’s a malfunction with the lab equipment, and Cata and six other teen patients are plunged into a shared dreamworld with no memory of how they got there. Even worse, they come to the chilling realization that they are trapped in a place where their worst nightmares have come to life. Hunted by creatures from their darkest imaginations and tormented by secrets they’d rather keep buried, Cata and the others will be forced to band together to face their biggest fears. And if they can’t find a way to defeat their dreams, they will never wake up.
I wasn’t a big fan of Amy Plum’s previous work but this one sounds so creepy and interesting that it’s a sure click for me
- The Black Witch – Laurie Forest
Elloren Gardner is the granddaughter of the last prophesied Black Witch, Carnissa Gardner, who drove back the enemy forces and saved the Gardnerian people during the Realm War. But while she is the absolute spitting image of her famous grandmother, Elloren is utterly devoid of power in a society that prizes magical ability above all else.
When she is granted the opportunity to pursue her lifelong dream of becoming an apothecary, Elloren joins her brothers at the prestigious Verpax University to embrace a destiny of her own, free from the shadow of her grandmother’s legacy. But she soon realizes that the university, which admits all manner of people—including the fire-wielding, winged Icarals, the sworn enemies of all Gardnerians—is a treacherous place for the granddaughter of the Black Witch.
As evil looms on the horizon and the pressure to live up to her heritage builds, everything Elloren thought she knew will be challenged and torn away. Her best hope of survival may be among the most unlikely band of misfits…if only she can find the courage to trust those she’s been taught to hate and fear.
Another interesting fantasy, and new to me author.
This is a small list of the titles coming out this week that have me going from mildly intrigue to complete fangirl meltdown. Let’s get to it.
- A Court Of Wings And Ruin – Sarah J. Maas.
Feyre has returned to the Spring Court, determined to gather information on Tamlin’s maneuverings and the invading king threatening to bring Prythian to its knees. But to do so she must play a deadly game of deceit-and one slip may spell doom not only for Feyre, but for her world as well. As war bears down upon them all, Feyre must decide who to trust amongst the dazzling and lethal High Lords-and hunt for allies in unexpected places.
Cue the happy dance.. first book I’m picking up that’s for sure.
- The Next Flame – Penelope Douglas
Together in one volume for the first time, New York Times bestseller Penelope Douglas’s two bestselling novellas in the Fall Away Series, full of intense emotion and smoking-hot passion. Aflame and Next to Never.
- Pipe Dreams – Sarina Bowen
Mike Beacon is a champion at guarding the net, but off the ice, he’s not so lucky. A widower and a single father, he’s never gotten over Lauren Williams, the ex who gave him the best year of his life. When Lauren reappears in the Bruisers’ office during the play-offs, Beacon sees his chance to make things right.
Lauren hates traveling with the team she used to manage and with the man who broke her heart. There’s still undeniable sexual tension running between her and Mike, but she won’t go there again. She’s focused on her plans for the future—she doesn’t need a man to make her dreams of motherhood come true.
Lauren plays her best defensive game, but she’s no match for the dark-eyed goalie. When the field of play moves to Florida, things heat up on the beach.
Only one of Mike’s fans doesn’t approve—his teenage daughter. But a true competitor knows not to waste the perfect shot at love.
Hockey romance, I need to get on this series ASAP.
- Red Wolf – Jennifer Ashley
A man is only as strong…
Red wolf Shifter Dimitri has fought his whole life for respect. It is claimed that red wolves are tainted with coyote blood and therefore not pure. He may not be skilled at verbally defending himself, but because he’s a bodyguard, tracker, and champion of the fight clubs, his fists are always ready for some rough and tumble. However, he’d prefer a roll in the hay with the woman who is his oldest friend.
…as the woman who’s got his back…
A spirited leopard Shifter and a fellow tracker, Jaycee Bordeaux has no problem forging a mate bond with Dimitri, but soon the two are called to infiltrate a rogue group bent on enslaving Shifters. Jaycee may have defended Dimitri from taunts before, but they now face a more lethal danger—one that threatens not only the future of their people, but also their love.
Book 10 already?? I’m so behind in this series it’s not even funny.
- The Untamed Vampire – Kate Baxter
Chelle is not your typical vampire. Turned not with a bite but an age-old magic, she’s the only one of her kind—and more powerful than most. Still adjusting to her endless thirst and lethal fangs, she’s desperate to discover what sets her apart. When she encounters a brutally virile alpha werewolf, she soon learns that she’s not immune to the mating call—and her own primal longing…
The leader of the ancient Forkbeard pack, Gunnar is stunned by Chelle’s lush beauty. The wild wolf inside him howls for her, but unions between vampire and werewolf are strictly taboo—even if their clans weren’t on the verge of war. Desire has never been so dangerous…but, as a malevolent new power rises, Chelle and Gunnar face an even more frightening threat. Together, they might find a way to save their clans. But can they claim their passion, in The Untamed Vampire by Kate Baxter.
I don’t know much about it but paranormal vampire romance guys and the female character’s name is Chelle. 🙂
- Until It Fades – K. A. Tucker –Pushed back until June 26th—
Twenty-four-year-old truck stop waitress and single mother Catherine Wright has simple goals: to give her five-year-old daughter a happy life and to never again be the talk of the town in Balsam, Pennsylvania (population three thousand outside of tourist season).
And then one foggy night, on a lonely road back from another failed date, Catherine saves a man’s life. It isn’t until after the police have arrived that Catherine realizes exactly who it is she has rescued: Brett Madden, hockey icon and media darling.
Catherine has already had her fifteen minutes of fame and the last thing she wants is to have her past dragged back into the spotlight, only this time on a national stage. So she hides her identity. It works. For a time.
But when she finds the man she saved standing on her doorstep, desperate to thank her, all that changes. There’s an immediate connection, and it’s more electric than the bond of two people who endured a traumatic event. It’s something neither of them expected. Something that Catherine isn’t sure she can handle; something she is afraid to trust.
Because how long can an extraordinary man like Brett be interested in an ordinary woman like Catherine…before the spark fades?
It sounds super emotional, totally worth checking out.
- Behind the Curtain – Beth Kery
On a break between overseas jobs, journalist Asher Gaites returns to his hometown of Chicago – and allows his friends to persuade him to check out a hot new singer. At a downtown jazz club, he’s soon transfixed by the lyrical voice and sensuous body of a woman who performs behind a thin, shimmering veil…
The veil gives Moroccan-American Laila Barek the anonymity she needs, since she has never been able to reconcile her family’s values with her passion for music. But one man is inexplicably drawn to her. And when Asher confronts her on a subway platform after a gig, he’s shocked to recognize the woman who walked away from him eight years ago…
Laila has never been able to forget the touch, the feel, the taste of Asher. And despite the doubt and fear that wind their way into their lives, they must trust the heat of their desire to burn down the walls the world has placed between them…
- Love me Again – Jaci Burton
When Loretta Simmons returns to Hope, Oklahoma, after a disastrous marriage, she’s determined to remain independent for the sake of her daughter. The only thing standing in her way is Deacon Fox—the man she loved and walked away from years ago.
Since Loretta owns the bookstore right next to his current renovation project, Deacon can’t escape the woman who broke his heart. Throw in her adorable little girl and one ridiculously oversized dog, and they’re almost a family. Only he can’t be that guy—what they had was once in a lifetime.
But love has a funny way of reopening a door you thought was firmly closed…
This is the last book of this Small town type of companion series and it sound really cute, another book for the TBR 🙂
- Textrovert – Lindsey Summers
It’s bad enough when high-school senior Keeley grabs the wrong phone while leaving her small town’s end-of-summer fair. It’s even worse when she discovers that the phone she now has belongs to the obnoxious, self-centered Talon and that he’s just left for football camp … with her phone. Reluctantly, the two agree to forward messages for a week. And as Keeley gets to know Talon, she starts to like him. Keeley learns there’s more to Talon than the egocentric jock most people see. There’s more to Keeley, too. Texting Talon, she can step out of the shadow of her popular twin brother. Texting Talon, she can be the person she’s always wanted to be.
Sparks fly when the two finally meet to exchange their phones. But while Keeley has been playing a part online, Talon has been keeping a secret. He has a different connection to Keeley — one that has nothing to do with phones, and one that will make their new relationship all but impossible. Knowing what she now knows, can Keeley trust him? And can love in the present erase mistakes of the past?
A cute first love and techy kind of story, sounds adorable right? 😉
- American Hellhound – Lauren Gilley
Still waiting on a Blurb for this book, and fingers crossed that comes out on May 6th but I love this series so much that I had to put it here.
This are just some of the New Releases for the week of May 2nd (not all of them just the ones that pick my fancy) I’ll update the list just as some other interesting sounding ones come out 😉
As Always happy reading.


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“P(acman) overcomes a key limitation of currently available methods because it allows you to study large chunks of DNA in vivo,?said Dr. Hugo Bellen, professor of molecular and human genetics at Baylor College of Medicine and director of the program in developmental biology. He is also a Howard Hughes Medical Institute investigator. The new technique allows researchers to study large genes and even gene complexes in the fruit fly, which was not possible before.
P/phiC31 artificial chromosome for manipulation, or P(acman), combines three recently developed technologies: a specially designed bacterial artificial chromosome (BAC) that allows maintenance of large pieces of DNA in bacteria, recombineering that allows the manipulation of large pieces of DNA that can then be inserted into the genome of the fly at a specific site using phiC31-mediated transgenesis.
It is a new technique with far-reaching promise, said Bellen.
P(acman) overcomes certain obstacles that have hampered research. It allows the cloning of large pieces of DNA to be used to transform the genome, and it permits that DNA to be inserted into specific places in the genome. Bellen credits the report’s first author, Koen J.T. Venken, a graduate student in the BCM Program in Developmental Biology, with putting the technologies together to come up with a new methodology in the field.
Current technology has certain problems for researchers seeking to understand the structure and function of genes, said Bellen. Often, when scientists breed flies that lack a particular gene and then try to put that gene back into the fly, it inserts itself randomly into the genetic blueprint.
In some cases, it makes too much protein, and in others, too little. In other instances, it may disrupt the message from another gene.
“You are really comparing apples and oranges when you do this,?said Bellen. The technique is also limited to small DNA chunks.
“Koen set out to develop a new transgenesis system using the three techniques,?said Bellen.
The bacterial artificial chromosome, or BAC, he used allows the scientist to maintain large chunks of DNA in the bacteria, but it is present in only one or few copies. However, the bacteria can be induced to produce many copies of the DNA when needed.
Koen then integrated a technique called “recombineering?into the strategy, which facilitates the scientist to clone large chunks of DNA and subsequently allows them to make specific mutations anywhere he or she wants in the gene.
The third technique allows the researcher to pinpoint where he or she wants to the mutant gene to go in the genetic blueprint of the fly, eliminating the apples-and-oranges problem. This third technique ?phiC31 ?works also in mouse and human cells, implying that this new technique could be used in those cells as well.
Source:Baylor College of Medicine
Related biology news :
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2. Unique library of plant genes germinates, takes root at UNC
3. New influenza vaccine takes weeks to mass produce
4. Oops! Researchers publish new findings on the brains response to costly mistakes
5. Blood flow in brain takes a twist, affecting views of Alzheimers
6. HIV vaccine takes different tack to boosting immune response
7. Taking evolutions temperature: Researchers pinpoint the energy it takes to make a species
8. For Stanford scientists, RNAi gene therapy takes two steps forward, one step back
9. Pitt phage hunter takes on tuberculosis
10. The brain, traffic and nano-circuits -- e-Science takes on major challenges
11. Diabetes research takes wing thanks to long-lived fruit fly


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Azerbaijan, Baku, July 4 / Trend , N.Ismayilova/
Construction of 220-kilovolt Mingechevir-Absheron electricity transmission lines, as part of the project approved last year worth $220 million dollars will start at least in the end of 2009, Economist of the Asian Development Bank Baku Office Rafael Abbasov said. At present, the tender is being held to determine a general contractor for design, development, purchase, delivery, installation and commissioning.
"Due to the large number of participants, the Asian Bank extended the tender procedure until August because this is one of the most active tenders due to the number of participants and one of the biggest projects in the energy sector, therefore, requires detailed elaboration of the proposals, but experts do not have time," Abbasov said.
He said over 20 companies applied to participate in the tender.
"Construction work on the results of the tender will be launched at least at the end of 2009," he added.
The project envisages constructing double 220 kV power lines from the Mingachevir Hydro Power Station to the Absheron substation. Moreover, it is planned to unit the 220/110-kV substation with the 110-kV power transmission line. The ADB Board of Directors issued a loan worth $160 million in September 2008.
The work includes the following components:
Substation Agdash (220/110 kV)
Electricity transmission line at 220 kV (257 km)
To expand the Absheron substation (500/330/220 kV).
Dismantling and local transportation
To build a new 220-kilovolt Agdash substation and its integration with the existing network;
To expand 220-kilovolt distribution equipment at Absheron substation to communicate with new overhead transmission lines and expand new 330/220-kilovolt transformer;
To fulfill measures to integrate and connect new transmission components to the SCADA system.
To build the 220-kilovolt new attachable transmission line at roughly 230-kilometers length between the Mingachevir, Agdash and Absheron substations;
To integrate the 220-kilovolt electricity transmission lines from Gabala to the north substation Agdash;
To re-arrange the 220-kilovolt dead-end tower in front of Absheron substation.
The project aims to increase the capacity of energy transmission systems and reduce regional imbalances in economic growth by means of adequate and reliable energy supply, as well as expand energy transmission capacity and improve the quality and reliability of energy supply.
Under the agreement, Azerbaijan will receive loans for 25 years with grace period of five years and an interest rate of libor +0.2 percent.
Azerbaijan cooperates with the ADB since 1999.
Do you have any feedback? Contact our journalist at [email protected]

domain: finance


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According to influencers, taking the best selfie is a mixture of lighting with interesting backgrounds. May be the key reason why they travel throughout the world to obtain the optimum selfie spot that can help them get the maximum number of likes (More on: Canada Tourist Visa Application form ). Canada is the perfect country for photography because you will find incredible scenery everywhere. But, to make this a lot simpler for you, I came down with a great list of places to take the best selfies in Canada while impressing your followers.
L1 visa process time find out more
Ripley’s Aquarium in Toronto, Ontario.
If you’re looking for unique selfies, Ripley’s Aquarium is the best location for it. You’ll be astonished by the 17 diverse habitats and 450 species while having the ability to take photos in the tank, as the aquarium has a tunnel for it. Plan for bluish backgrounds and dark lighting.
Toronto Pearson International Airport
It may seem is cliche to consider a selfie in the airport, however the Toronto Pearson has two fantastic and unique area for selfies. The first is the black, giant modern steel sculpture made by Richard Serra called Tittle Spheres (2004), this notable work of art is a people favorite because it is a very photogenic point. The second reason is the Plaza Premium Lounge, for its gorgeous design elements around a 6200 square foot area. The dark wood accents turn the Lounge into the best selfie spot at the airport.
The park is located in Stratford, Ontario. Surrounded by roses, herbs and English flowers, Shakespeare Garden is exceptional for romantic selfies. You are able to make use during sunrise or sunset for fantastic effects, since the park looks wonderful at summertime.
Situated in Eganville, Ontario, Bonechere Caves is the most wonderful natural underground space. Even if your lighting in the cave is based on a flashlight, you’ll be able to take very distinctive shots since you will face a wooden walkway, interesting patterns, and rock formations.
Picture by: kanada wiza
La Tour CN
Most commonly known as CN Tower is amongst the highest towers in America. Even when you can photograph selfies from various spots across the city with the tower in the background, including the Harbourfront Centre or any Toronto Islands, the most notable spot is at the observatory in the tower. You can be with impressive selfies with the ideal Toronto skyline.
This fun park has lots of picture-worthy backdrops and it’s called the most Instagrammed places in Canada. The very first location you should visit is the Wonder Mountain because it is a fantastic mix of a gorgeous nature background and the wonderful floral garden. Secondly, the Royal Fountain. It has a amazing blue sky, combined with a roller coaster and the fantastic fountain, the right site for a amazing selfie.
Algonquin Provincial Park
For its astonishing nature view, the Algonquin Provincial Park is home to superb photographs moments. You will find over 2000 lakes inside the park, each with its singularity. There isn’t any better place for nature lovers to capture the majestic view within the photo.
Source: canadian visa


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Genomes and Genes
dipeptidyl peptidase i
Summary: A cysteine-type peptidase that is CHLORINE dependent and functions maximally at acidic pHs. At neutral pH, it polymerizes esters, aryl- and dipeptide amides. EC 126.96.36.199.
Publications132 found, 100 shown here
- Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritisApril M Adkison
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
J Clin Invest 109:363-71. 2002..To investigate the role of these proteases in inflammation, we generated a mouse deficient in dipeptidyl peptidase I (DPPI) and established that DPPI is required for the full activation of CG, NE, and PR3...
- The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2Anne Mølgaard
Centre for Crystallographic Studies, University of Copenhagen, Universitetsparken 5, DK 2100 Copenhagen Ø, Denmark
Biochem J 401:645-50. 2007hDDPI (human dipeptidyl peptidase I) is a lysosomal cysteine protease involved in zymogen activation of granule-associated proteases, including granzymes A and B from cytotoxic T-lymphocytes and natural killer cells, cathepsin G and ..
- Dipeptidyl peptidase I: importance of progranzyme activation sequences, other dipeptide sequences, and the N-terminal amino group of synthetic substrates for enzyme activityTinh V Tran
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332 0400, USA
Arch Biochem Biophys 403:160-70. 2002The broadly reactive cysteine protease dipeptidyl peptidase I (DPPI, cathepsin C) is thought to activate all progranzymes (zymogens of lymphocyte serine proteases) to form mature granzymes...
- Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteasesD Turk
Department of Biochemistry and Molecular Biology, Jozef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
EMBO J 20:6570-82. 2001b>Dipeptidyl peptidase I (DPPI) or cathepsin C is the physiological activator of groups of serine proteases from immune and inflammatory cells vital for defense of an organism...
- Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humansChristine T N Pham
Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
J Immunol 173:7277-81. 2004..proteases depends on the N-terminal processing activity of the lysosomal cysteine protease cathepsin C/dipeptidyl peptidase I (DPPI)...
- Identification of cathepsin C mutations in ethnically diverse papillon-Lefèvre syndrome patientsP S Hart
University of Pittsburgh, Department of Human Genetics, Pittsburgh, PA 15261, USA
J Med Genet 37:927-32. 2000..To date, 13 different cathepsin C mutations have been reported in PLS patients, all of which are homozygous for a given mutation, reflecting consanguinity...
- Biochemical and mutational analyses of the cathepsin c gene (CTSC) in three North American families with Papillon Lefèvre syndromeY Zhang
Center for Craniofacial and Dental Genetics, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA 15261, USA
Hum Mutat 20:75. 2002..These mutations altered restriction enzyme sites in the highly conserved CTSC gene. Sequence analysis of CTSC exon 3 confirmed the previously reported p.T153I polymorphism in 4 of the 5 ethnically diverse populations studied...
- Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosisVivien R Sutton
Cancer Immunology Program, Research Division, Peter MacCallum Cancer Centre, East Melbourne, Vic, Australia
J Cell Biol 176:425-33. 2007..Cathepsin C deficiency also results in considerably milder immune deficiency than perforin or granzyme A/B deficiency...
- Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processingS W Dahl
Prozymex A S, Dr Neergaards vej 17, DK 2970 Hørsholm, Denmark
Biochemistry 40:1671-8. 2001Human dipeptidyl peptidase I was expressed in the insect cell/baculovirus system and purified in its active (rhDPPI) and precursor (pro-rhDPPI) forms...
- Papillon-Lefèvre syndrome: mutations and polymorphisms in the cathepsin C geneA Nakano
Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Jefferson Institute of Molecular Medicine, 233 South 10th Street, Suite 450 BLSB, Philadelphia, PA 19107, USA
J Invest Dermatol 116:339-43. 2001..Addition of these cathepsin C gene mutations into the expanding Papillon-Lefèvre syndrome mutation database allows further development of genotype/phenotype correlations towards understanding this severe genodermatosis...
- A novel mutation of the cathepsin C gene in Papillon-Lefèvre syndromeVanessa F Cury
Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
J Periodontol 73:307-12. 2002..However, genotypic and phenotypic correlation has not been established. In the present study we investigated the CTSC gene in a Brazilian cohort affected by PLS...
- Novel point mutations, deletions, and polymorphisms in the cathepsin C gene in nine families from Europe and North Africa with Papillon-Lefèvre syndromeC Lefevre
Centre National de Genotypage, Evry, France
J Invest Dermatol 117:1657-61. 2001..Hum Mutat 17:152-153, 2001)...
- Cloning and characterization of the cDNA encoding mouse dipeptidyl peptidase I (cathepsin C)M J McGuire
Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas 75235 8577, USA
Biochim Biophys Acta 1351:267-73. 1997The mouse dipeptidyl peptidase I cDNA has been cloned and sequenced and patterns of DPPI mRNA expression in various tissues characterized...
- Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivoC T Pham
Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Proc Natl Acad Sci U S A 96:8627-32. 1999b>Dipeptidyl peptidase I (DPPI) is a lysosomal cysteine protease that has been implicated in the processing of granzymes, which are neutral serine proteases exclusively expressed in the granules of activated cytotoxic lymphocytes...
- Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosisC Toomes
Department of Medical Genetics, St Mary s Hospital, Manchester, UK
Nat Genet 23:421-4. 1999..In two of these families we used a functional assay to demonstrate an almost total loss of cathepsin C activity in PLS patients and reduced activity in obligate carriers...
- Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to Sendai virus infectionAntonina M Akk
Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 180:3535-42. 2008..In this study, we show that the absence of dipeptidyl peptidase I (DPPI), a lysosomal cysteine protease found in neutrophils, dampens the acute inflammatory response and ..
- Cathepsin C gene: First compound heterozygous patient with Papillon-Lefèvre syndrome and a novel symptomless mutationL M Allende
Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain
Hum Mutat 17:152-3. 2001..On the other hand, PLS patients are ameliorated by retinoids, which indicates that retinoids may be used as therapeutic agents in this immune system deficiency...
- Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndromeT C Hart
Department of Pediatrics, Section of Medical Genetics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
J Med Genet 36:881-7. 1999..A more complete understanding of the functional physiology of cathepsin C carries significant implications for understanding normal and abnormal skin development and periodontal disease susceptibility...
- Human dipeptidyl-peptidase I. Gene characterization, localization, and expressionN V Rao
Department of Internal Medicine, Division of Respiratory, Critical Care, and Occupational Medicine, University of Utah Health Sciences Center and Veterans Administration Medical Center, Salt Lake City, Utah 84132, USA
J Biol Chem 272:10260-5. 1997..The results provide initial insights into the molecular basis for the regulation of human dipeptidyl-peptidase I...
- Dipeptidyl peptidase I regulates the development of collagen-induced arthritisYing Hu
Washington University School of Medicine, St Louis, MO 63110, USA
Arthritis Rheum 52:2553-8. 2005To examine the role of dipeptidyl peptidase I (DPPI), a widely expressed lysosomal cysteine protease, in the development of collagen-induced arthritis (CIA) in mice.
- A family with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activityJosephine L Meade
Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds LS9 7TF, United Kingdom
Blood 107:3665-8. 2006..This is the first documented example of a human mutation affecting granzyme B activity and highlights the importance of cathepsin C in human NK cell function...
- Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritisGraeme S Cottrell
Center for the Neurobiology of Digestive Disease, Department of Surgery, University of California, San Francisco, San Francisco, California 94143 0660, USA
Gastroenterology 132:2422-37. 2007..We studied the role of protease-activated receptor 2 (PAR(2)) and its activating enzymes, trypsins and tryptase, in Clostridium difficile toxin A (TxA)-induced enteritis...
- Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysmsMonica B Pagano
Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63124, USA
Proc Natl Acad Sci U S A 104:2855-60. 2007b>Dipeptidyl peptidase I (DPPI) is a lysosomal cysteine protease critical for the activation of granule-associated serine proteases, including neutrophil elastase, cathepsin G, and proteinase 3...
- Haim-Munk syndrome and Papillon-Lefèvre syndrome are allelic mutations in cathepsin CT C Hart
University of Pittsburgh, School of Dental Medicine, Department of Oral Medicine Pathology, 628 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA
J Med Genet 37:88-94. 2000..We also report a mutation of the same exon 6 CTSC codon (2126C-->T) in a Turkish family with classical PLS. These findings provide evidence that PLS and HMS are allelic variants of cathepsin C gene mutations...
- Purification and characterization of dipeptidyl peptidase I from human spleenM J McGuire
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
Arch Biochem Biophys 295:280-8. 1992The lysosomal hydrolase, dipeptidyl peptidase I (DPPI), was purified from human spleen and its enzymatic activity characterized...
- A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin CFang Yuan
Department of Pathology, and Microbiology and Immunology, Stanford School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA
J Am Chem Soc 128:5616-7. 2006b>Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides...
- Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutationT C Hart
Department of Oral Medicine Pathology, University of Pittsburgh, School of Dental Medicine, 614 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA
J Med Genet 37:95-101. 2000..This is the first reported gene mutation for non-syndromic periodontitis and shows that non-syndromic PPP is an allelic variant of the type IV palmoplantar ectodermal dysplasias...
- Free-thiol Cys331 exposed during activation process is critical for native tetramer structure of cathepsin C (dipeptidyl peptidase I)Martin Horn
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 16610 Praha, Czech Republic
Protein Sci 11:933-43. 2002..In conclusion, the mechanism of tetramer formation as well as specific posttranslational processing segregates CC in the family of papain proteases...
- Mast cell dipeptidyl peptidase I mediates survival from sepsisJon Mallen-St Clair
Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, California 94143 0911, USA
J Clin Invest 113:628-34. 2004Sepsis is a common, life-threatening disease for which there is little treatment. The cysteine protease dipeptidyl peptidase I (DPPI) activates granule-associated serine proteases, several of which play important roles in host responses ..
- Identification of a novel cathepsin C mutation (p.W185X) in a Brazilian kindred with Papillon-Lefèvre syndromeP S Hart
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, 572A Scaife Hall, 3550 Terrace St, PA 15261, USA
Mol Genet Metab 76:145-7. 2002..This family segregates a novel PLS-related mutation, p.W185X, that is associated with a complete loss of enzymatic activity...
- Selective inhibition of dipeptidyl peptidase I, not caspases, prevents the partial processing of procaspase-3 in CD3-activated human CD8(+) T lymphocytesNicolas Bidere
Laboratoire de Greffes d Epithéliums et Régulation de l Activation Lymphocytaire, Unité INSERM 542, Hopital Paul Brousse, 94807 Villejuif, France
J Biol Chem 277:32339-47. 2002..dmk, a selective inhibitor of dipeptidyl peptidase I, was effective...
- Inhibition of dipeptidyl peptidase I in the human mast cell line HMC-1: blocked activation of tryptase, but not of the predominant chymotryptic activityParimal D Sheth
Immunopharmacology Group, Division of Infection, Immunity and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, UK
Biochem Pharmacol 66:2251-62. 2003..The cysteinyl protease dipeptidyl peptidase I (DPPI, cathepsin C) can activate the corresponding proenzymes in cell-free systems, but it is unknown ..
- Molecular cloning, chromosomal localization, and expression of murine dipeptidyl peptidase IC T Pham
Department of Internal Medicine, Washington University Medical School, St Louis, Missouri 63110 1093, USA
J Biol Chem 272:10695-703. 1997b>Dipeptidyl peptidase I (DPPI) is a lysosomal cysteine protease that catalyzes the sequential removal of dipeptides from the amino termini of various protein substrates...
- Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in miceP J Wolters
Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, California 94143 0911, USA
J Biol Chem 276:18551-6. 2001b>Dipeptidyl peptidase I (DPPI) is the sole activator in vivo of several granule-associated serine proteases of cytotoxic lymphocytes. In vitro, DPPI also activates mast cell chymases and tryptases...
- Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in miceJon Mallen-St Clair
Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0111, USA
Biol Chem 387:1143-6. 2006The cysteine protease dipeptidyl peptidase I (DPPI) activates granule-associated immune-cell serine proteases...
- Design and evaluation of inhibitors for dipeptidyl peptidase I (Cathepsin C)Chih Min Kam
School of Chemistry and Biochemistry and the Petit Institute for Bioscience and Bioengineering, Georgia Institute of Technology, Atlanta, GA 30332 0400, USA
Arch Biochem Biophys 427:123-34. 2004b>Dipeptidyl peptidase I (DPPI, cathepsin C) is a lysosomal cysteine protease that can activate zymogens of several different serine proteases by one step or sequential removal of dipeptides from the N-termini of the pro-protease protein ..
- Processing of procarboxypeptidase A and other zymogens in murine mast cellsM M Dikov
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0111
J Biol Chem 269:25897-904. 1994..Thus, mast cell carboxypeptidase, tryptase, and chymase zymogens are each processed to their active forms by different mechanisms...
- Regulated expression, processing, and secretion of dog mast cell dipeptidyl peptidase IP J Wolters
Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, California 94143 0911, USA
J Biol Chem 273:15514-20. 1998b>Dipeptidyl peptidase I (DPPI) is a cysteine protease found predominantly in myelomonocytic cells, cytotoxic T-cells, and mast cells...
- Demonstration of altered splicing with the IVS3-1G --> a mutation of cathepsin CMohamad Nusier
Department of Biochemistry and Molecular Biology, Jordan University of Science and Technology, Irbid, Jordan
Mol Genet Metab 75:280-3. 2002..Sequencing of the mutant transcript revealed that it lacked exon 3, resulting in a frameshift and introduction of a premature termination codon...
- Evidence of a founder effect for four cathepsin C gene mutations in Papillon-Lefèvre syndrome patientsY Zhang
Department of Oral Biology, University of Pittsburgh School of Dental Medicine, 614 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA
J Med Genet 38:96-101. 2001..Identification of these six short tandem repeat polymorphisms that span the cathepsin C gene will permit haplotype analyses to determine other founder haplotypes of cathepsin C mutations in additional PLS families...
- New developments in the genetics and activation of mast cell proteasesGeorge H Caughey
Department of Medicine, Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA 94143 0911, USA
Mol Immunol 38:1353-7. 2002..New biological tools, including the dipeptidyl peptidase I (DPPI)-null mouse in which the entire class of mast cell chymases appears to be functionally knocked out, ..
- Papillon Lefevre syndromeS V Dhadke
Department of Medicine Dr VM Medical College Solapur
J Assoc Physicians India 54:246-7. 2006..Pyogenic liver abscess is an increasingly recognized complication. We report a new case of this association and review the current literature...
- Novel mutations in the cathepsin C gene in patients with pre-pubertal aggressive periodontitis and Papillon-Lefèvre syndromeB Noack
J Dent Res 83:368-70. 2004..947T>G, c.1268G>C) in a PLS patient. We conclude that at least a subset of pre-pubertal AP is due to CTSC mutations and therefore may be an allelic variant of PLS...
- Phenotypic variation and allelic heterogeneity in young patients with Papillon-Lefèvre syndromeChrister Ullbro
Department of Dentistry, King Faisal Specialist Hospital, Research Centre, Riyadh, Saudi Arabia
Acta Derm Venereol 86:3-7. 2006..Young girls displayed significantly less palmoplantar hyperkeratosis ( p < 0.05) than young boys. In conclusion, considerable phenotypic heterogeneity was observed within the two cardinal mutations and in the 189/189 genotype...
- Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5Frida Henningsson
Swedish University of Agricultural Sciences, Department of Veterinary Medical Chemistry, The Biomedical Center, Box 575, S 751 23 Uppsala, Sweden
Biol Chem 384:1527-31. 2003..The present study thus indicates novel roles for cathepsins C and S in regulating the levels of stored proteases in the mast cell secretory granules...
- Late-onset Papillon-Lefèvre syndrome without alteration of the cathepsin C geneUlrike Pilger
Department of Dermatology, Karl Franzens University, Graz, Austria
J Am Acad Dermatol 49:S240-3. 2003..Our patient with late-onset variation of PLS, however, did not show a mutation in the cathepsin C gene. Thus, we suspect that there is another genetic cause for the late-onset forms of PLS...
- New syndrome of hypotrichosis, striate palmoplantar keratoderma, acro-osteolysis and periodontitis not due to mutations in cathepsin CM A M van Steensel
Department of Dermatology, University Medical Centre St Radboud Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Br J Dermatol 147:575-81. 2002..We propose that our patients suffer from a new syndrome possibly caused by mutations in a gene that has a functional or structural relation with CTSC...
- Purification and characterization of cathepsin J from rat liverT Nikawa
Division of Enzyme Chemistry, University of Tokushima, Japan
Eur J Biochem 204:381-93. 1992..J. & Ellis, S. (1964) Biochem. Biophys. Res. Commun. 16, 135-140]. Furthermore, antiserum against rat liver cathepsin C reacted with rat liver cathepsin J. These findings suggested that cathepsin J is identical with cathepsin C...
- Carbohydrate- and conformation-dependent cargo capture for ER-exitChristian Appenzeller-Herzog
Department of Pharmacology and Neurobiology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
Mol Biol Cell 16:1258-67. 2005..To our knowledge this is the first documentation of an ER-exit signal in soluble cargo in conjunction with its decoding by a transport receptor...
- Cathepsin C involvement in the aetiology of Papillon-Lefevre syndromeCristina Frezzini
Int J Paediatr Dent 14:466-7. 2004
- A novel mutation of the cathepsin C gene in a thai family with Papillon-Lefevre syndromeHiroshi Nitta
Department of Comprehensive Oral Health Care, Behavioral Dentistry, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
J Periodontol 76:492-6. 2005..This study demonstrates the clinical manifestations and CTSC mutational and enzymatic activity analyses in a 5-year-old Thai male PLS patient and his parents...
- Papillon-Lefèvre syndrome and malignant melanoma. A high incidence of melanoma development in Japanese palmoplantar keratoderma patientsKoji Nakajima
Department of Dermatology, Hirosaki University School of Medicine, Hirosaki, Japan
Dermatology 217:58-62. 2008..This tendency might be attributable to the high frequency of acral lentiginous melanoma in Japanese subjects, in contrast to a lower frequency of this subtype in Caucasians...
- Gene symbol: CTSC. Disease: Papillon-Lefevre syndromeW Beertsen
Department of Periodontology, Academic Centre for Dentistry Amsterdam, Universiteit van Amsterdam, The Netherlands
Hum Genet 116:545. 2005
- Loss-of-function mutations in cathepsin C in two families with Papillon-Lefèvre syndrome are associated with deficiency of serine proteinases in PMNsSusanne F de Haar
Department of Periodontology, Academic Centre for Dentistry Amsterdam ACTA, Universiteit van Amsterdam, Amsterdam, The Netherlands
Hum Mutat 23:524. 2004..Serine proteinases are supposed to be important in both the innate and adaptive immune systems. Their absence in PLS patients could explain the inadequate defense to periodontal infection...
- Genes involved in Alzheimer's disease, a survey of possible candidatesAlessandro Serretti
Department of Psychiatry, Vita Salute University School of Medicine, Fondazione Centro San Raffaele del Monte Tabor, Milan, Italy
J Alzheimers Dis 7:331-53. 2005..The aim of this review is to explore genetics of AD...
- Papillon-Lefèvre syndrome: case report and review of the literatureShahbaz A Janjua
Ayza Skin and Research Center, Lalamusa, Pakistan
Dermatol Online J 10:13. 2004..These findings are consistent with Papillon-Lefèvre syndrome. The clinical presentation, differential diagnosis, complications and management of this syndrome are discussed...
- Novel mutations of cathepsin C gene in two Chinese patients with Papillon-Lefèvre syndromeY Yang
Department of Pedodontics, Peking University, Beijing, People s Republic of China
J Dent Res 86:735-8. 2007..851G>A and c.112delCCTG) in the other patient. Our novel discovery indicates that the phenotypes observed in these two patients are due to the CTSC gene mutation...
- Clinical, genetic, and biochemical findings in two siblings with Papillon-Lefèvre SyndromeN Arzu Cagli
Department of Periodontology, Faculty of Dentistry, Selcuk University, Konya, Turkey
J Periodontol 76:2322-9. 2005..Cathepsin C (CTSC) gene mutations are etiologic for PLS. The resultant loss of CTSC function is responsible for the severe periodontal destruction seen clinically...
- Functional Cathepsin C mutations cause different Papillon-Lefèvre syndrome phenotypesBarbara Noack
Department of Conservative Dentistry, University Hospital Carl Gustav Carus, TU Dresden, Germany
J Clin Periodontol 35:311-6. 2008..This study aimed to identify CTSC mutations in different PLS phenotypes, including atypical forms and isolated pre-pubertal aggressive periodontitis (PAP)...
- The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitisChelsee Hewitt
Department of Medical Genetics University of Manchester, Manchester, UK
Hum Mutat 23:222-8. 2004..These data suggest that prepubertal periodontitis is a genetically heterogeneous disease that, in some families, just represents a partially penetrant PLS...
- Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complexBeat Nyfeler
Biozentrum, University of Basel, CH 4056 Basel, Switzerland
Traffic 7:1473-81. 2006..The results indicate that ERGIC-53 can bind cargo glycoproteins in an MCFD2-independent fashion and suggest that MCFD2 is a recruitment factor for blood coagulation factors V and VIII...
- Cathepsin Cs are key for the intracellular survival of the protozoan parasite, Toxoplasma gondiiXuchu Que
Department of Pathology, University of California, San Diego, California 92103 8416, USA
J Biol Chem 282:4994-5003. 2007..gondii in the chick embryo model of toxoplasmosis. Thus, cathepsin Cs are critical to T. gondii growth and differentiation, and their unique specificities could be exploited to develop novel chemotherapeutic agents...
- Use of compact, porous units with immobilized ligands with high molecular masses in affinity chromatography and enzymatic conversion of substrates with high and low molecular massesD Josic
Octapharma Pharmazeutika Produktionsges, mbH, Wien, Austria
J Chromatogr A 803:61-71. 1998..The enzyme dipeptidyl peptidase i.v...
- Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and diseaseD P Dickinson
Medical College of Georgia, School of Dentistry, Department of Oral Biology, and Maxillofacial Pathology, Augusta 30912, USA
Crit Rev Oral Biol Med 13:238-75. 2002..Human cathepsins are best known from the ubiquitously expressed lysosomal cathepsins B, H, and L, and dipeptidyl peptidase I (DPP I), which until recently were considered to mediate primarily "housekeeping" functions in the cell...
- Lysosomal degradation of cholecystokinin-(29-33)-amide in mouse brain is dependent on tripeptidyl peptidase-I: implications for the degradation and storage of peptides in classical late-infantile neuronal ceroid lipofuscinosisFrancesca Bernardini
Department of Cellular Pathology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
Biochem J 366:521-9. 2002..Other tissues are spared because they express another peptidase, DPP-I, which has extensive activity on peptides and can compensate for the loss of TPP-I...
- Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidaseMohammed Sajid
Department of Pathology, Tropical Disease Research Unit and Sandler Centre for Basic Research in Parasitic Diseases, University of California San Francisco, Box 0511, San Francisco, CA 94143, USA
Mol Biochem Parasitol 131:65-75. 2003..This study characterizes the major digestive cysteine peptidase in schistosomes and defines novel trans-processing events required to activate the SmCB1 zymogen in vitro which may facilitate the digestive process in vivo...
- Removal of N-terminal polyhistidine tags from recombinant proteins using engineered aminopeptidasesJ Pedersen
UNIZYME Laboratories, Dr Neergaards vej 17, Horsholm, DK 2970, Denmark
Protein Expr Purif 15:389-400. 1999..The method is based on the use of the aminopeptidase dipeptidyl peptidase I (DPPI), either alone or in combination with glutamine cyclotransferase (GCT) and pyroglutamyl ..
- Lysosomal enzyme activities: new potential markers for Sjögren's syndromeNicolette Sohar
Department of Ophthalmology, University of Szeged, A Szent Györgyi Medical and Pharmaceutical Center, Szeged, Hungary
Clin Biochem 38:1120-6. 2005..To evaluate the changes in lysosomal enzyme activities in leukocytes of patients with Sjögren's syndrome...
- Therapeutic utility and medicinal chemistry of cathepsin C inhibitorsDaniel Guay
Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada
Curr Top Med Chem 10:708-16. 2010The lysosomal cysteine protease cathepsin C (Cat C), also known as dipeptidyl peptidase I, activates a number of granule-associated serine proteases with pro-inflammatory and immune functions by removal of their inhibitory N-terminal ..
- Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseasesBrice Korkmaz
INSERM U 618 Protéases et Vectorisation Pulmonaires, Universite Francois Rabelais, Faculte de Medecine, 10 boulevard Tonnelle, Tours, France
Pharmacol Rev 62:726-59. 2010..All three proteases are affected by mutations of the gene (CTSC) encoding dipeptidyl peptidase I, a protease required for activation of their proform before storage in cytoplasmic granules...
- Increased collagenase and dipeptidyl peptidase I activity in leucocytes from healthy elderly peopleL Llorente
Department of Immunology and Rheumatology, Instituto Nacional dela Nutrición Salvador Zubirán, Mexico City, Mexico
Clin Exp Immunol 116:425-9. 1999..substrates employed were for oxidative burst, L-aminopeptidase, collagenase, cathepsin B, C, D and, G and dipeptidyl peptidase I. The intracellular enzyme activity assessed by flow cytometry in leucocytes from young and elderly women ..
- Variation of proteolytic activity in ewe during in vivo digestion of two pea-based diets differing by their fermentability characteristicsM Sales-Duval
ENSAIA, Laboratoire de Sciences Animales, Vandruvre les Nancy
Reprod Nutr Dev 41:297-308. 2001..diet II, exopeptidase activities increased more in the liquid phase, especially leucine aminopeptidase and Dipeptidyl peptidase I (DPP-I), and the diversity of endopeptidase activities increased in the particulate phase...
- Cell-type specificity of l-leucyl l-leucine methyl esterY Kobayashi
Department of Biomolecular Science, Faculty of Science, Toho University, Chiba, Japan
Biochem Biophys Res Commun 272:687-90. 2000..methyl ester (LeuLeuOMe) is a lysosomotropic agent which is converted to a membranolytic compound by dipeptidyl peptidase I and kills human leukocytes such as CD8+ T cells and monocytes but not B cells...
- Inhibitors of cathepsin C (dipeptidyl peptidase I)Dramane I Laine
GlaxoSmithKline, Respiratory CEDD, King of Prussia, PA 19406, USA
Expert Opin Ther Pat 20:497-506. 2010Cathepsin C (dipeptidyl peptidase I) plays a key role in the activation of several degradative enzymes linked to tissue destruction in inflammatory diseases...
- Innate immune response mechanisms in non-insulin dependent diabetes mellitus patients assessed by flow cytoenzymologyL Llorente
Department of Immunology and Rheumatology, Instituto Nacional de la Nutricion Salvador Zubiran, Vasco de Quiroga 15, Tlalpan CP 14000, Mexico, D F, Mexico
Immunol Lett 74:239-44. 2000..Other mechanisms - either from the non-specific or specific immune response - deserve investigation to establish if diabetic patients are more susceptible to infectious diseases...
- Expression and characterization of recombinant mast cell tryptaseH Chan
Department of Molecular Biology, Department of Enzymology, Department of Pharmacology, Axys Pharmaceuticals, Inc, 180 Kimball Way, South San Francisco, California, 94080, USA
Protein Expr Purif 15:251-7. 1999..of active recombinant tryptase required a two column purification protocol and included a heparin- and dipeptidyl peptidase I-dependent activation step...
- Fas and TNFR1, but not cytolytic granule-dependent mechanisms, mediate clearance of murine liver adenoviral infectionMarwan S Abougergi
Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9151, USA
Hepatology 41:97-105. 2005..of secreted or intracellular adenoviral gene products was not delayed in perforin-deficient mice or dipeptidyl peptidase I-deficient mice, which fail to process and activate granzyme A or granzyme B...
- Bifidobacterium bifidum monoassociation of gnotobiotic mice: effect on enterocyte brush-border enzymesH Kozakova
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 549 22 Novy Hradek, Czechia
Folia Microbiol (Praha) 46:573-6. 2001..This effect of B. bifidum supplementation was less pronounced for alkaline phosphatase, sucrase, glucoamylase and dipeptidyl peptidase i.v. in immature gut of weaned mice than of 2-month-old ones.
- Novel semicarbazide-derived inhibitors of human dipeptidyl peptidase I (hDPPI)Jon Bondebjerg
Combio A S, Vesterbrogade 188, DK 1800 Frederiksberg C, Denmark
Bioorg Med Chem 13:4408-24. 2005Human dipeptidyl peptidase I (hDPPI, cathepsin C, EC 188.8.131.52) is a novel putative drug target for the treatment of inflammatory diseases...
- Identification of genetic risk factors for periodontitis and possible mechanisms of actionBruno G Loos
Department of Periodontology, Acadcemic Center for Dentistry Amsterdam ACTA, University of Amsterdam, The Netherlands
J Clin Periodontol 32:159-79. 2005..To review the literature for genetic risk factors associated with periodontitis...
- Papillon-Lefévre syndrome: a highly-suspected caseAtsushi Ikeshima
Department of Radiology, Nihon University School of Dentistry at Matsudo, Chiba, Japan
J Oral Sci 48:257-60. 2006..However, the special precautions normally applied to prevent infections in PLS patients undergoing dental treatment were taken...
- Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defenseR Robert Vethanayagam
Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America
PLoS ONE 6:e28149. 2011..neutrophil elastase (NE)(-/-)×cathepsin G (CG)(-/-) mice and lysosomal cysteine protease cathepsin C/dipeptidyl peptidase I (DPPI)-deficient mice that are defective in neutrophil serine protease activation demonstrated no ..
- Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis)Brice Korkmaz
Centre d Etude des Pathologies Respiratoires, INSERM U 1100 EA 6305, 37032 Tours, France
Semin Immunopathol 35:411-21. 2013..proteinase 3 (PR3), and neutrophil serine protease 4 are four hematopoietic serine proteases activated by dipeptidyl peptidase I during neutrophil maturation and are mainly stored in cytoplasmic azurophilic granules...
- Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysisGarth Hamilton
Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dundee, UK
EMBO J 27:499-508. 2008..Thus, cystatin F is a latent protease inhibitor itself regulated by proteolysis in the endocytic pathway. By targeting cathepsin C, it may regulate diverse immune cell effector functions...
- Dermatologic, periodontal, and skeletal manifestations of Haim-Munk syndrome in two siblingsShahbaz A Janjua
Ayza Skin and Research Center, Lalamusa, Pakistan
J Am Acad Dermatol 58:339-44. 2008....
- Carica papaya glutamine cyclotransferase belongs to a novel plant enzyme subfamily: cloning and characterization of the recombinant enzymeS W Dahl
Unizyme Laboratories A S, Dr Neergaards vej 17, Horsholm, Denmark
Protein Expr Purif 20:27-36. 2000..was correctly processed by the host signal peptidase and the His-tag could subsequently be removed with dipeptidyl peptidase I. The expressed products were characterized by activity assays, SDS-PAGE, N-terminal amino acid sequencing, ..
- Effect of epsilon-aminocaproylaminoacids on the activity of proteolytic enzymesI Bruzgo
Institute of Chemistry, , Poland
Acta Pol Pharm 58:137-40. 2001..Slight inhibition of trypsin and chymotrypsin activity was observed only at high concentrations of these compounds. All tested dipeptides did not influence activities of cathepsin B, cathepsin C and cathepsin D...
- The human gene FALL39 and processing of the cathelin precursor to the antibacterial peptide LL-37 in granulocytesG H Gudmundsson
Department of Microbiology, Stockholm University, Sweden
Eur J Biochem 238:325-32. 1996..To obtain LL-37 for antibacterial assays, synthetic FA-LL-37 was degraded with dipeptidyl-peptidase I. This analysis showed that mature LL-37 is a potent antibacterial peptide...
- Phytochelatin synthase, a dipeptidyltransferase that undergoes multisite acylation with gamma-glutamylcysteine during catalysis: stoichiometric and site-directed mutagenic analysis of arabidopsis thaliana PCS1-catalyzed phytochelatin synthesisOlena K Vatamaniuk
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6018, USA
J Biol Chem 279:22449-60. 2004....
- Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemiaRavi Kothapalli
H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Int J Oncol 22:33-9. 2003..Importantly, the pattern of gene expression in leukemic LGL resembles that seen in activated cytotoxic T cells (CTL)...
- Production of active bovine cathepsin C (dipeptidyl aminopeptidase I) in the methylotrophic yeast Candida boidiniiT Komeda
Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Fukuura, Kanazawa Ku, Yokohama shi, Kanagawa, Japan
Appl Microbiol Biotechnol 59:252-8. 2002..When the recombinant C. boidinii was grown for 90 h in a jar-fermenter, active CTC was secreted with a yield of up to approximately 12 mg/l...
- Calcium entry into keratinocytes induces exocytosis of lysosomesRalph Jans
Département Histologie Embryologie, Facultes Universitaires Notre Dame de la Paix, 5000 Namur, Belgium
Arch Dermatol Res 296:30-41. 2004..These results suggest that upon ionomycin treatment, calcium entry stimulates exocytosis of lysosomes in keratinocytes...
- Synthesis and activity of phosphinic tripeptide inhibitors of cathepsin CArtur Mucha
Institute of Organic Chemistry, Biochemistry and Biotechnology, Wrocław University of Technology, Wybrzeze Wyspianskiego 27, 50 370 Wrocław, Poland
Bioorg Med Chem Lett 14:3113-6. 2004..However, although designed as transition state analogues, they surprisingly exhibited noncompetitive mode of binding to cathepsin C. Differences in kinetics of C-terminal acids and esters have been additionally observed...
- Leucyl-leucine methyl ester-treated haploidentical donor lymphocyte infusions can mediate graft-versus-leukemia activity with minimal graft-versus-host disease riskMichael H Hsieh
Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
Biol Blood Marrow Transplant 8:303-15. 2002L-leucyl-L-leucine methyl ester (LLME) prevents GVHD in several animal models by depleting dipeptidyl peptidase I (DPPI)-expressing cytotoxic cellular subsets...
- Oligomeric structure and substrate induced inhibition of human cathepsin CI Dolenc
Department of Biochemistry and Molecular Biology, J Stefan Institute, Ljubljana, Slovenia
J Biol Chem 270:21626-31. 1995..2, 6.8, and 7.7 are involved in substrate hydrolysis. Human cathepsin C thus appears to differ qualitatively from other cysteine proteinases of different origin...
- A genetic study of cathepsin C gene in two families with Papillon-Lefèvre syndromeLuis M Allende
Department of Immunology, Hospital 12 de Octubre, Ctra Andalucia, Madrid 28041, Spain
Mol Genet Metab 79:146-8. 2003..Family 2 shows a previously described non-sense homozygous punctual change (72C>A) that introduces a termination codon at the extracellular domain of the protein (C24X)...
- Dipeptidyl peptidases in human muscle diseaseN C Kar
Clin Chim Acta 82:185-92. 1978..b>Dipeptidyl peptidase I showed maximum activity at pH 5.0-6.0. Dipeptidyl peptidase II was maximally active at pH 5...
- Cathepsin C and plasma glutamate carboxypeptidase secreted from Fischer rat thyroid cells liberate thyroxin from the N-terminus of thyroglobulinDejan Suban
Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI 1000 Ljubljana, Slovenia
Biochimie 94:719-26. 2012..We focused on the extracellular action of two lysosomal enzymes, cathepsin C (catC, dipeptidyl peptidase I) and PGCP (lysosomal dipeptidase), on thyroglobulin, and their ability to liberate the hormone thyroxin...
- Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domainJ G Olsen
Center for Crystallographic Studies, University of Copenhagen, Denmark
FEBS Lett 506:201-6. 2001The crystal structure of mature dipeptidyl peptidase I reveals insight into the unique tetrameric structure, substrate binding and activation of this atypical papain family peptidase. Each subunit is composed of three peptides...
- Detection of an intragenic deletion expands the spectrum of CTSC mutations in Papillon-Lefèvre syndromeThomas Jouary
Departement de Dermatologie, Hôpital Saint André, Bordeaux, France
J Invest Dermatol 128:322-5. 2008..We consider that this technique should be performed in patients with apparently homozygous CTSC mutations when one parent does not carry the expected mutation or is not available for analysis...
- Specific localization of lysosomal aminopeptidases in type II alveolar epithelial cells of the rat lungY Yayoi
Department of Cell Biology and Neuroscience, Osaka University Graduate School of Medicine, Suita, Japan
Arch Histol Cytol 64:89-97. 2001....
- Inflammatory Proteases and Cardiac Repair after Myocardial InfarctionAbdelkarim Sabri; Fiscal Year: 2013..Pilot study shows that NSP deletion in-vivo using DiPeptidyl Peptidase I (DPPI) KO mice, mice that lack major NSPs, attenuated myocyte death following MI and resulted in smaller ..
- Mast Cells and the Host Response in the LungPaul Wolters; Fiscal Year: 2007..Recently, we made the discovery that the mast cell protease dipeptidyl peptidase I (DPPI) contributes to death of the host from septic peritonitis and that it appears to do so by regulating ..
- LLME TREATED T LYMPHOCYTE THERAPY AFTER ALLOGENEIC BMTNeal Flomenberg; Fiscal Year: 2002..The proposed grant will support a trial to administer increasing numbers of LLME-treated DLI to patients and monitor patients for CD4 recovery and other parameters of immune reconstitution as well as for development of GVHD. ..
- CYTOTOXIC CELLS AND ALLOIMMUNE RESPONSESDwain Thiele; Fiscal Year: 2002..abstract): The studies detailed in this application will examine the role of the granule thiol protease, dipeptidyl peptidase I (DPPI) in generation of cytotoxic T lymphocyte (CTL) effector functions and the evolution of in vivo ..
- MAST CELL CYSTEINE PROTEASES IN LUNG INFLAMMATIONPaul Wolters; Fiscal Year: 2003..We hypothesize that tissue mast cells are a major source of dipeptidyl peptidase I (DPPI) and a newly identified 60-kDa cysteine protease and that these proteases participate in ..
- PULMONARY EMPHYSEMA--ROLE OF SERINE PROTEINASESJohn Hoidal; Fiscal Year: 2000....
- DPPI AND CELL MEDIATED IMMUNITYChristine Pham; Fiscal Year: 2001..4. We will create a null mutation in the DPPI gene using homologous recombination in embryonic stem cells and analyze the function of immune effector cells derived from these mice. ..
- CYTOTOXIC CELLS AND ALLOIMMUNE RESPONSESDwain Thiele; Fiscal Year: 2004..Proposed studies will focus on the role of the granule thiol protease, dipeptidyl peptidase I (DPPI), in both the generation of cytotoxic T lymphocyte (CTL) effector function and in the regulation of ..
- Role of DPPI & Serine Proteases in Inflammatory DiseasesChristine Pham; Fiscal Year: 2007..We also hypothesize that decreased expression of complement regulators in the kidney mav be a determinant that influences the severity of tissue damage in the target organ. ..