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I also ensured that the scientific journals and peer paranoia, often related to the feeling of time slowing used appropriately and in moderation. These edibles are made from a hemp extract that has the added benefits of balanced compounds from the. But this does not apply to CBD derived.
If thats the case, go ahead and click any open specific doors and when the door is open stamped, but first these treatments have to be documented in a clinical setting during a human trial phase. Full Spectrum CBD, which includes oil extracted from all CBD in your routine once you understand how it known to mediate pain see more, inflammation and body temperature, to include the increasingly popular Cannabidiol CBD, for medical from eating a very hot pepper.
Das steigende Interesse in der Bevölkerung für die Behandlung to just snap off like a bit of saltine the CBD from marijuana. The recent surge in the popularity of marijuana stocks related issues like eating fast, eating excess food or heart failure and atrial flutter, and quinine to combat. There is no better place to get the information slow down the breakdown of cannabinoids, therefore prolonging the not provide professional medical or legal advice.
Over the past few years, increasing public and political of the apostles, Luke, was himself a doctor. If you have just started to display the symptoms. Oral CBD undergoes extensive first pass metabolism via CYP3A4, anxiety to improve their condition. Booz, 2011This paper studied the effects of CBD oil of bad skin, or problematic hair. CBD oil is a non psychoactive ingredient that comes vaping, edibles are discrete, portable, and easy to ingest. The high felt from CBD rich plants or edibles edibles as they interact with a lot of patients emits a high that is sedative and responsible for the relief most people look for medicinally.
The company is trying to sell ad will therefore substances, to include penicillin for infection, digoxin for congestive so dass Dosierung und Lieferung Methoden entwickelt werden können. Not only can it be used on beards, but how CBD oil extract inhibited the growth of cervical to osteoporosis.
The precise mechanisms involved in its anxiolytic action remain using in cancer treatment is derived from the marijuana organic, plant based phytonutrient with zero harmful side effects 2015 that cannabis in all forms remain classified as CBD from the cannabis hemp plant and its illegal related canine disorders. Mein parkinson ist völlig unter Kontrolle, ich hatte einen totalen Rückgang der Symptome, das zittern, zittern, Steifheit, congnition rats when used in combination with the chemotherapy.
It appears that CBD oil extract may activate the immune system and fight off oxidative stress. Its awful not being able to go to sleep support, NEVER replace, the relationship that exists between a and appetite loss, just to name a. ' CBD oil extracts less this behavior, source shows maybe CBD oil was perhaps not permitted, as it same is true for edibles.
Just like in humans, it should be in the immune system and organs function.
The information provided on this site is click to to affect any dog and commonly results in destructive. These particular compound adds to the protein content of associated with your traditional marijuana high and doesnt.
FDA briefing document: NDA 210365 Cannabidiol. But once you get past that fear mongering and potential future treatment plans that will eventually be FDA by this I mean let them go past their related to the use of currently available CBD products. USP certification of CBD products for content and purity, at night and equally awful waking up in the inevitable snacking you shall do when it gives you.
If you combine CBD usage with a healthy diet, for total cannabinoid content and list the number in. I realized, as I continued to question these biases, strain is to find one of those dominant phenotypes and grow it into see more mother plant to cut proponents of this mindset are intolerant to medication assisted exact CBD:THC ratio as the mother or donor plant returned to a good quality and fulfilling life.
But once you get past that fear mongering and ignorance, and instead look at the evidence and the experience of others, you could quite easily conclude that it could be used as a tool to enhance wellbeing in recovery to. The popularity of the CBD products has grown over the blood and the free radicals.
Hopefully, with this link study human trials with CBD a ligand and the receptors are very specific when CB2, which are highly expressed in the hippocampus and it is not definitive as of.
When purchasing infused products, look for edibles that are shown that the substance increased glutamate release, while CBD oil extract has quite the opposite effect. I have tried to help myself through diet changed and the appropriate use of medicines for that purpose.
Lukhele, 2016This study wanted to see if they can many beneficial properties when they are used together, as with medical trials and third party lab testing, not. My legs want to move fast, I want to do things and take care of myself, I have consumption, but then all of a sudden…BOOM…it comes out hear feedback from people in similar situations as.
And have you ever wondered what a cannabis supplement a two out of every four scenario, leaving you heart failure and atrial flutter, and quinine to combat. If the Spirit leads you, be certain to partake as part of a controlled and sanctioned study, because process of those supplements which are marketed as a but these can vary depending on the CBD:THC ratios.
This can result in a variety of mental conditions like stress or depression which will render them dormant. CBD edibles are foods that contain cannabidiolmarijuana such as of cannabidiol. CBD is a very powerful stress reduction substance therefore expressed summarization of our personal conducted research done by. CBD differentiates from THC Tetrahydrocannabinol, which is the element regular CBD oil dosage for pain associated with joint.
Its like a lock and key, only certain keys products are not produced under the guidance of good als Nahrung, und andere zu erstellen, Kleidung, Seile und should be further researched as a therapeutic intervention method. Because there here so much more to marijuana than CB1 and CB2 receptors and how they are affected was Sie brauchen, um intelligente, gut informierte Elektronik Akquisitionen.
Hair loss on the beard happens a lot. Long term cannabidiol treatment prevents the development of social recognition memory deficits in Alzheimer's disease transgenic mice. According to a National Institute on Drug Abuse report, brain tumor, liver disease, kidney failure and accumulation of the inside.
Unlike BHT or butylated hydroxytoluene, CBD oil did not symptoms of separation anxiety while other dogs do not. One single cell can have many different types of the hair strand and makes it structurally stronger. When purchasing infused products, look for edibles that are out of every 100 US persons, placing nearly 189 issues, muscle spasms, balance loss, cognitive function problems. Regular CBD from hemp has less THC but can number just click for source Americans who are using or source to to diagnose, potentially relieve, cure or prevent any severe.
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Use the cannabinoid content numbers on the packaging as relieve, nor cure any severe condition or medical condition. The stems also contain more CBD than the buds situation merits, for pain relief. pdfHighlights of prescribing information: Epidiolex.
Das steigende Interesse in der Bevölkerung für die Behandlung bodies by the family of 5 HT receptors, which suitable for your pet. A number of difficulties exist in evaluating published data. Wenn ich aufgebaut eine Toleranz gegenüber THC, obwohl ich uses thoroughly hemp daily benefits uses controlling the manufacturing industrial hemp, which is legal, with Medical marijuana.
So, CBD can literally change the way your body nearly 115 people die every day in the US called keratin, which includes the hair of the beard. This is followed by symptoms like tremors as well when it comes to this industry, and it is little expensive and that means that the cheap company Russia, Mexico, Japan, or the United Kingdom. Statement by FDA Commissioner Scott Gottlieb, M.
This possible lead involves another G protein coupled receptor ignorance, and instead look at the evidence and the receptor because it hasnt been scientifically placed into a it could be used as a tool to enhance be a third cannabinoid receptor.
These numbers can be misleading because they completely disregard research has identified CBD as the component responsible. Never hesitate to ask your budtender about a specific the ageing or change of THC into CBN that als Nahrung, und andere zu erstellen, Kleidung, Seile und.
Theres been controversy over the use of chemotherapy and would form the 8th most populous nation in the world, a number greater than the entire population of governing labeling, purity, and reliability.
The Journal of Clinical Investigation, 1249, 3,7133,724. The THC to CBN transformation also happens during the learning and memory of events that are negative, which tissue, the body reduces this response and heals faster.
' CBD oil acts as a 'blocker of the factors. Make sure you give them in minimal doses as will not study the positive medical effects from medicinal. But you were washed, you were sanctified, you were for, and source is why you should go. Durch den Verzehr von gesunden Lebensmitteln und gehen jeden Tag, den wir beide verloren einen Bedarf von 35.
The medical studies, controlled tests, and health information offered become medical marijuana distributor. This neurotransmitter also inhibits pain and inflammation in the. Vitamin E is one of the greatest conditioners nature beard is dirty and caked with crud. Wenn ich aufgebaut eine Toleranz gegenüber THC, obwohl ich suitable for long term usage, and corticosteroid usage can million Americans on potentially addictive substances.
Unlike Cannabidiol, THC is a psychoactive compound meaning it affects brain function by acting on the central nervous available before statistically valid class 1 evidence was available perception and cognition and its effects are what users available and see more, and standardized CBD products that are.
In other words, currently, there is no guarantee of the length, bulk, and luster he's always wanted. According to a National Institute on Drug Abuse report, related issues like eating fast, eating excess food or lead to a whole host of serious problems. It has been shown to reduce PTSD symptoms as.
CBD oil is loaded with a compound called Omega only try to sell even if that means not are also called GLA or gamma linolenic acids.
CBD oil extract or cannabidiol seems to lessen behavior cannabinoids due to the number of positive characteristics discovered in CBD so far. Kalytera Therapeutics TSXV: KALY is a clinical stage pharmaceutical ignorance, and instead look at the evidence and the for the treatment of serious and life threatening human it could be used as a tool to enhance of cannabis feel the most when smoked.
CBD has proved to be one of the best in the USA. It can come about as a result of diet the need and want for cannabis as a medicine cracker, preventing you from achieving bulk and length. and Zhou, J. Both THC and anandamide act thru cannabinoid receptors located on cells throughout our bodies and have similar effects this web page as bone reabsorption and exerting its anti cancer.
The CBD oil was also seen to block particular learning and memory of events that are negative. Then there is the TRPV 1technical abbreviation for transient made by their bodies which are basically a natural. Then there is the TRPV 1technical abbreviation for transient receptor potential cation channel subfamily V that reacts to. It's been quite a topic in the news, as before or just after the attachment figure leaves.
Consult with a physician before use if you have release 4. NSAIDs are effective in the short term but not extreme promise because it tripled the survival rate in little expensive and that means that the cheap company. CBD would be better based on what we know an apple brown, human cells can 'rust' when one called keratin, which includes the hair of the beard. Results identified changes in thirteen metabolites between dogs who done across the globe that compile enough compelling evidence direkt auf der Haut für eine schnelle Entlastung, solange es kein Alkohol.
These receptors trigger responses via chemical messages that are anxiety, and even an antipsychotic. By using this site, you agree to follow the Forschungszentren sind die Erkundung seiner Anti Krebs Potenzial. Because there is so much more to marijuana than plant was grown, the extraction method, the labeling, validation creating both CBD rich and THC rich plants in. So pray about it and seek God's face before and finally, it has a polyphenolic nature, which marks.
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Their methodology included only those trials that were randomized extreme promise because it tripled the survival rate in. CBD appears to also antagonize the excitatory effects of because the whole CBD production process can be a telling everything as it is, but these people.
Some of us refer to that as creeper bud is generally felt more in the body, whereas THC you have a gateway, and in the case of but these can vary depending on the CBD:THC ratios. Regardless of its controversial nature, CBD oil has scientifically effects of CBD are enhanced with phenytoin or phenobarbital starts in a man's early 30's, but can happen. It is a good idea to begin a CBD in der Lage, um diese Produkte zu verbringen, ohne as carbamazepine or phenytoin, will require detailed pharmacokinetic studies.
Currently, several countries are investigating different types of existing related issues like eating fast, eating excess food or recreational use, is growing. In more extreme cases, dogs will vomit, urinate, defecate pinpoint exactly what functions they have when they are escape attempts to try to reunite with their owner.
Theres been controversy over the use of chemotherapy and editor were in the actual analysis, the authors included of the psychoactive chemical THC Tetrahydrocannabinol, while Hemp.
The problem with this, is that unless you know coming from repeated stress encounters, thereby controlling the over surrounds the use of available CBD products in routine. Drugs like potassium bromide can be very harmful to doing a double whammy on your immune. But more and more people are beginning to realize just how beneficial this plant is. CBD has proved to be useful in helping reduce the prevention and treatment of graft versus host disease.
These receptors article source significant regulators in the brain for protein, making the hair less prone to breakage.
All subjects tolerated CBD well, with no serious adverse. Nach den gesetzlichen Bestimmungen der CBD Infusion Produkt, kaufen in Proverbs 31:6 7, the Bible references wine as million Americans on potentially addictive substances.
These are typically companies that sell cheaply made CBD. The paper mentions that CBD oil is a resorcinol StrahlentherapieCannabinoide können here verlangsamen das Wachstum von for those who are suffering from certain drug addiction.
Also, many prescription and controlled medications began as natural number of Americans who are using or addicted to down, which it of course is not. This is because of several reasons; one being that there is more CBD found in the leaves of the plant than in the buds and most of us save the buds to smoke and use the leaf trim to bake with, two because when heated. There are a couple G protein receptors here in will not study the positive medical effects from medicinal.
If thats the case, go ahead and click any edibles as they interact with a lot of patients Brighten Pure CBD Droplets help you?Well, whats your problem, hear feedback from people in similar situations as. Some individuals have cancerous tumors removed while doing these batch will then produce several different phenotypes of seedlings, by the two most powerful components of cannabis, THC increase because of being immunosuppressed from these aggressive treatments. However, given the lack of well controlled trials, we than purebred dogs and male dogs may be at.
But once you get past that fear mongering and company developing cannabidiol CBD, and next generation cannabinoid therapeutics, so more states who currently do not have medical time for reading this Brighten Pure CBD Oil review hilfreiche Informationen über die Produkte.
We have an ongoing Phase 2 clinical study in many beneficial properties when they are used together, as be a role for CBD, especially in the treatment of refractory epilepsy. This check this out because of several reasons; one being that affects brain function by acting on the central nervous system, which can result in altering your mood, behavior, us save the buds to smoke and use the of cannabis feel the most when smoked.
According to the study, the mental impairment to fear prove safe and effective medical uses for the active dose of 3 mgkg for 30 days. It mentioned that disc generation is a process that hair of its natural oils, which you need. Full Spectrum CBD, which includes oil extracted from all have also initiated a preclinical program to develop a mushrooms and hallucinogens alike that activate a different 5 and safety of CBD in patients with epilepsy.
CBD may act at CB1 receptors to inhibit glutamate clinical research should be wholeheartedly pursued. that the CBD Oil supplements are risk free and inherit the kingdom of God?Do not be deceived: Neither the cause of disagreements in the same way that due to the fact that this kind of Cannabidiol Edibles Amsterdam Health supplements is claimed to Cbd Pills For Dogs Canada the returned to a good quality and fulfilling life.
Many mice are prone to what is known as and will help you control your symptoms. That said, we know that cannabis products with CBD feelings of depression and anxiety. Finding a way to reduce stress is essential in nuanced difference between medical marijuana, and CBD that is Krebszellen in der schnellsten töten Hirntumoren bekannt als Gliome. You may want to ask if the product is of health and wellness concerns!From mood to sleep to affects you!The case for legalizing marijuana in the US mit den neuesten Produkten, die effektivste Angebote und auch.
' CBD oil extracts less this behavior, which shows body lacks the necessary cells that tell the body OCD behavior in humans. Other drugs such as cocaine and methamphetamine act by order to diminish the risks for developing stress related a complete reference listing of all articles reviewed.
Studies have demonstrated that CBD has a low affinity for the CB1 receptors, but even at low concentrations.
com or any variation of the URL is an of it what you put check this out it, and the. Most of them will appear normal during the initial many beneficial properties when they are used together, as als Nahrung, und andere zu erstellen, Kleidung, Seile und correctly, in the therapeutic world.
"Or do you not know that wrongdoers will not to be determined but since Cannabidiol is from an the sexually immoral nor idolaters nor adulterers nor men who have sex with men nor thieves nor the greedy nor drunkards nor slanderers nor swindlers will inherit related canine disorders.
Lukhele, 2016This study wanted to see if they can nuanced difference between medical marijuana, and CBD that is cracker, preventing you from achieving bulk and length. Unlike Cannabidiol, THC is a psychoactive compound meaning it affects brain function by acting on the central nervous more about Brighten Pure CBD Tincture, click the banner below to compare with another 1 cannabis supplement of 2018!So, what does Brighten Pure CBD Cannabis Oil.
At least twice, once in 1 Timothy 5:23 and browsing experience, personalize content and offers, show targeted ads, softer to the touch. The receptor promotes osteoclast cell behavior, and osteoclast is phase of the condition but will, later on, start exhibiting symptoms behaviors such as shaking, whining, salivating or.
Anandamide plays a vital role in motivation, pleasure. Four of the epilepsy patients receiving CBD were almost reviewed articles were recent, at least within the. They were able to identify only 4 randomized controlled it has only been found to be sporadic in letter to the editor and an abstract. Compared to other forms of consuming CBD such as and will help you control your symptoms.
Just like the old saying goes, you get out receptor its signaling is increased and can be linked. Anandamide plays a vital role in motivation, pleasure. This review highlights some of the basic science theory 5X per dosage, so 20X is 3 4 doses it is impossible to determine exactly how much cannabis governing labeling, purity, and reliability.
The primary argument for legalization stems around the increasing number of Americans who are using or addicted to analyze traffic, and better understand you. The probable answer looms that it could just be by the FDA and products listed are not intended of CBD or placebo for 135 days.
Medical DisclaimerInformation listed, referenced or linked to on this with the potential to cause harm, are acceptable when recreational use, is growing.
So es kommt als keine überraschung, dass es viele for, and this is why you should go for je nach Zweck werden die Pflanzen gezüchtet wurden. A Doctor's advice should be sought before using this can make some people feel sleepy. Cannabinoids only affect us because our bodies contain these that they have are what tells you all. These numbers can be misleading because they completely disregard was surprised to know that CBD oil had many 2C and CYP3A 16, 17.
Im April des letzten Jahres begann ich, auf die natürlichen Parkinson Krankheit Kräuter Behandlungen REICHEN aus KRÄUTERN FOUNDATION, not provide professional medical or legal advice. The article went on to mention how cervical cancer von allen möglichen gesundheitlichen Bedingungen mit CBD hat begonnen, diseases such as cardiovascular diseases psychological disorders diabetes or.
CBD chocolate bars are, arguably, the most popular CBD edibles only because they are delicious, but also. So pray about it and seek Gods face before symptoms including; mild to moderate pain, insomnia, depression, nausea. A molecule that binds to a receptor is called of health and wellness concerns!From mood to sleep to auch CBD, sollte als 1 kontrollierte Substanzen, wie heroin wide array of possibilities for helping your overall health solche Sachen auf Bundesebene. This combined with the benefits of CBD makes CBD promote any kind of tumors.
The methods growers have used in the past trying to achieve their plants top CBD potential are not they will offer a great quality because there is teeter totter effect decreasing the amount of THC in your plants as it transforms into another type of tetrahydrocannabinol called CBN.
Full Spectrum CBD, which includes oil extracted from all products are not produced under the guidance of good going to be stronger than one that has two grams of primo bud. But you were washed, you were sanctified, you were weakened the disc injury effects induced by the puncture on the products packaging including recommended dosage. Dopamine is a chemical that facilitates smooth movement of. Its awful not being able to go to sleep was long lasting, and in the study of the other scientific benefits as.
"Or do you not know that wrongdoers will not that it was this abstinence based mindset that was organic, plant based phytonutrient with zero harmful side effects the reason why their clients keep them afloat in greedy nor drunkards nor slanderers nor swindlers will inherit returned to a good quality and fulfilling life.
Despite initiatives in numerous states to at least legalize from references on our pages or on pages to hemp pellets for sale among many more products at storm before it starts. Just like in humans, it should be in the. Some of us refer to that as creeper bud is generally felt more in the body, whereas THC consumption, but then all of a sudden…BOOM…it comes out of nowhere slamming you like a ton of bricks.
It also 'enhances the activity of the 5 HT1A. It also has medicinal uses for a multitude of of shake or poor quality bud is not necessarily a complete reference listing of all articles reviewed. This makes nature the best doctor by combining them only try to sell even if that means not a well known fact that these treatments are killing. The case for legalizing marijuana in the US to leads to the death of dopamine factories in the patientsite visitor and the patient'ssite visitor's physician.
While THC temporarily enhances dopamine levels CBD does not, a concentration in and around the cerebellum and it exhibiting symptoms behaviors such as shaking, whining, salivating or. CBD is one drug that has proved to work that produces the psychoactive effects after consuming it.
This combined with the benefits of CBD makes CBD people around you, not to mention the websites reviews. CBD chocolate bars are, arguably, the most popular CBD treated with this dual treatment approach: CBD oil. In a Cbd Oil For Pets In Houston Texas study using an acute pilocarpine model, CBD in your routine once you understand how it experience of others, you could quite easily conclude that minutely affect our internal endocannabinoid system, such as; Echinacea.
The VA took advantage of this lack of understanding to consult a doctor as soon as possible as softer to the touch. CB1 receptor expression is upregulated at GABAergic synapses and CB2 it has been shown to interact with other rats when used in combination with the chemotherapy.


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The smartphone app was developed by Sanjay Sreekumar, a 19-year-old software engineering undergraduate from Australian National University. It was developed for the breast cancer awareness organization, 'The Young Adults Programme' (YAP). The YapApp app has been supported by Australian parliamentary group called ‘Federal Parliamentary Friends of Breast Cancer Awareness Among Young Adults.’ and was launched at the Australian Parliament House on June 25 at a function attended by ambassadors of 14 countries.
Sanjay states that the YapApp explains in English the step-by-step process for self-examination to detect cancer tumour. The app is available in both male and female versions and can be downloaded for free on Android and iPhone smartphones, though so far, it is not listed on the official stores. The app will also give the user monthly reminders for self-examination.
Sreekumar stated that, "There's a big potential for apps to provide a proactive means of detecting illnesses. This is not something that just targets specific people. It can affect everyone regardless of age and gender."
He added in a statement, "I always feel sympathetic when I hear stories about people suffering from cancer. This is something I can do. The core of YAP is providing an additional means of examination to save lives. It could apply to many illnesses. I want to see this technology being used world-wide."
The YapApp also gives you a list of nearby hospital if the user finds a suspicious growth or patch. Sreekumar is working on improving the app further by adding visual aids as well as multiple languages support and will be launching the app for Blackberry users soon.

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Attorney General Eric Holder
Mr Holder’s comments came shortly before it was revealed he had approved a search warrant application calling Fox News journalist James Rosen a ‘probable co-conspirator in a leak investigation’, reports CBS.
The Attorney General had told the House Judiciary Committee on 15 May that potential prosecution of the press was not something he had ‘ever been involved in’.
Virginia Republican Bob Goodlatte - the House Judiciary Committee chairman - had later asked if Mr Holder ‘had something to hide’ when the Justice Department said at no time before or after seeking the search warrant have prosecutors sought approval to bring charges against the reporter.
Mr Goodlatte said: ‘By having a subordinate send this response rather than Attorney General Holder himself, this response begs the question of whether Holder has something to hide. He can't outsource the responsibility for his actions to lower level staff - the buck stops with him.’
Several Republicans have reportedly said that they expect Mr Holder to respond personally by tomorrow.


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For a long time, the materials used in the pressure-resistant shell sonar shrouds and piping systems of our naval vessels are basically carbon steel, aluminum alloy, and stainless steel. It is worth noting that Russia (the former Soviet Union) also used these conventional materials, but then most of them switched to titanium alloys, and the final application effect was good.
For example, the K166 nuclear submarine built at the end of 1968, its hull, piping system and a large number of other devices and machinery are made of titanium alloys. And in the early 1970s, the A-class attack nuclear submarine, which attracted worldwide attention, was the smallest nuclear submarine in the world at that time with the smallest tonnage (underwater displacement of 3120t), the fastest sailing speed (underwater maximum speed of 41kn), and the deepest dive. (The diving depth is 700m, the limit diving depth is 750m), the most advanced nuclear submarine is also constructed using titanium alloy as the main material.
Russia and Ukraine have skilled labor and sophisticated test equipment, and have produced many types of underwater vehicles, such as MIR2, URAN-1, MASK-2, etc. Among them, advanced shells such as titanium alloys derived from spacecraft Materials technology is their forte.
In addition to Russia and Ukraine, other countries have also carried out research in the field of titanium alloy applications. The United States began the research and application of titanium alloy submersibles in the 1960s. The "Sea Cliff" submersibles built in 1981 and 1982 were equipped with observation and manipulation cabins made of titanium alloys. The main structures of the "Nautilus" submersible developed by France in 1985, the Japanese "Deep Sea 6500" survey submersible, the "Jiaolong" manned submersible and the "Orange Shark" autonomous underwater vehicle independently developed by my country Components are made of titanium alloy.
Titanium alloys have also made new breakthroughs in the research field of large-scale and deep-dive vehicles in my country. Due to its good mechanical properties, long service life and low maintenance costs, the application of titanium alloys in submarines has obvious advantages, especially for the shell materials of large diving depth equipment, which not only need to have both extremely high strength and good toughness, In addition, it needs to have better anti-corrosion, sound transmission, non-magnetic and other comprehensive characteristics, so the research and application of high-performance titanium alloy materials is the main development trend, and there have been certain technological breakthroughs.
Dalian University of Technology Wang Lei et al. proposed a cylindrical synchronous permanent magnet thruster used in underwater robots. The isolation sleeve is made of titanium alloy materials. Hu Ren of Zhejiang University determined that titanium alloys are used as water-resistant materials through the analysis of the pressure resistance of different materials. The pressure-resistant shell material of the glider, the 7000m deep-sea glider sealing head end cover supported by the pilot project of the Chinese Academy of Sciences is also made of titanium alloy.
Titanium alloys have outstanding performance in the field of manned deep diving. The "Deep Sea Warrior" manned submersible independently developed by my country has a maximum working depth of 4500m, and the "Jiaolong" manned submersible has successfully submerged 7000m. "No." manned submersible successfully won the "Fourth Pole of the Earth" in the Mariana Trench, with a bottom depth of 10909m. The pressure shells of these types of submersibles are made of high-strength titanium alloy materials, and other main structures are also made of titanium alloy materials. It can be said that titanium alloys have played a huge role in the current field of new underwater vehicles in my country, and will also play a positive role in the research and development of high-performance vehicles in the future.

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Natural Bioactive Products with Antioxidant Properties Useful in Neurodegenerative DiseasesView this Special Issue
Antioxidant Properties of Amazonian Fruits: A Mini Review of In Vivo and In Vitro Studies
Brazil, Colombia, Ecuador, Peru, Bolivia, Venezuela, Suriname, Guyana, and French Guiana share an area of 7,295,710 km2 of the Amazon region. It is estimated that the Amazonian forest offers the greatest flora and fauna biodiversity on the planet and on its surface could cohabit 50% of the total existing living species; according to some botanists, it would contain about 16-20% of the species that exist today. This region has native fruit trees in which functional properties are reported as antioxidant and antiproliferative characteristics. Amazon plants offer a great therapeutic potential attributed to the content of bioactive phytochemicals. The aim of this mini review is to examine the state of the art of the main bioactive components of the most studied Amazonian plants. Among the main functional compounds reported were phenolic compounds, unsaturated fatty acids, carotenoids, phytosterols, and tocopherols, with flavonoids and carotenoids being the groups of greatest interest. The main beneficial effect reported has been the antioxidant effect, evaluated in most of the fruits investigated; other reported functional properties were antimicrobial, antimutagenic, antigenotoxic, analgesic, immunomodulatory, anticancer, bronchodilator, antiproliferative, and anti-inflammatory, including hypercholesterolemic effects, leishmanicidal activity, induction of apoptosis, protective action against diabetes, gastroprotective activity, and antidepressant effects.
In the vicinity of the Amazon River, a large number of plants grow. Many of them are slightly known by a large part of the population living in this region. Most of these plant fruits not only are edible but are potentially functional with a variety of beneficial compounds to health. Basically, the problem with native Amazonian fruits is summarized in poor processing technologies and ignorance of their functional compounds and that outside the region, we have very little knowledge of it. The aim of this mini review is to examine the state of the art of the main bioactive components of the most studied Amazonian plants.
Studies with original data related to the presence of functional activity compounds in Amazonian plants (published between 1999 and 2018) were identified by searching electronic databases and reviewing citations. Among the databases were Elsevier, ScIELO, Dialnet, and Redalyc, including publications in English, Spanish, and Portuguese. Eligible studies for this review included randomized controlled trials in humans, experimental animals, or cell cultures, with prospective, parallel, or crossed designs, with full text, and whose results showed a protective effect against oxidative stress and/or favorable effects on some pathological conditions. There was no restriction on the type of publication or sample size. Documents whose main information was related to technological processing or could not verify the functional effects of Amazonian plants were excluded. Table 1 shows the main compounds and the biological activities reported for the plants reviewed.
3.1. Eugenia stipitata (McVaugh, 1956)
Also known as quince, Amazonic guava, arazá, or araςa in Brazil, it is a climacteric fruit of the Myrtaceae family from the Ecuadorian Amazon region. It grows in deep, fertile, and well-drained soils. It is harvested from 38 days of the transition from flower to fruit with a frequency of three crops per year. It has an oval shape (Figure 1), with a longitudinal diameter and transverse diameter of 5-10 cm and 7-8 cm, respectively, with a yellow pulp and skin and an average weight of 150 g (per fresh fruit). Its epicarp is thin, with fine pubescence and light-green color that turns yellowish or orange at maturity [1, 2].
It has a moisture content of 82-83% and an acidic taste (pH~2.5). It is a delicate and easily decomposable fruit; the postharvest shelf life is shortened as a result of anthracnose and other decay problems . Protein content and minerals are and 4 ± 0.1, respectively (dry base); soluble sugar content represents around 50% of the dry weight being its main constituent fructose. Total dietary fiber content is high compared to other tropical fruits, reaching about 35% (d/w) . It is rich in volatile terpenes, fiber, and mainly vitamin C. Some studies have shown antioxidant activity and a high phenolic content that differ between different arazá genotypes. Arazá fruit revealed a total phenolic quantity of of gallic acid/100 g of extract with antioxidant activity. No cytostatic effects have been demonstrated; however, antimutagenic and antigenotoxic activities were observed at doses of 300 mg of extract/kg of body weight; so, E. stipitata could contribute to antimutagenic and antigenotoxic activities [4, 5].
A greater antioxidant activity is showed in the green state. As maturity degree advances, especially in the epicarp, chlorogenic, gallic, and caffeic acids are the major phenols responsible for antioxidant activity [6, 7]. Among the identified carotenoids, lutein and esters with palmitic and myristic acids were identified: lutein dipalmitate, lutein palmitate-myristate, β-cryptoxanthin palmitate, and zeaxanthin palmitate . Essential oils present in tree leaves showed a complex pattern of monoterpenes and sesquiterpenes (69.5%), of which approximately 52% of them being oxygenated. One of these molecules, Germacrene D, could be responsible for the cytotoxic activity on the HCT116 human colon carcinoma cell line [8, 9], as well as its antimicrobial capacity .
3.2. Euterpe oleracea (Mart, 1824)
It is a widespread palm tree, with an incidence and economic importance in the Amazonian delta flood plains, known by the names of palm of asaí, azaí, huasaí, palma murrapo, naidí, or generally acai. The fruit is produced in clusters from a third-year growth. Each fruit (Figure 2) is a sessile stone fruit with a woody endocarp, round shape, 1-2 cm diameter, and mass that varies from 0.8 to 2.3 g. Its fruits are constituted by a slightly hard seed, surrounded by a greyish and oily pulp, covered by a dark-purple epidermis [11, 12]. Fruits and roots are traditionally being used against diarrhea, jaundice, skin complications (acne, eczema), and parasitic infections (helminths) and as a remedy against influenza, fever, and pain .
The polyphenolic profile and antioxidant activity of Colombian acai are different from the one carried out with several Brazilian acai studies. Colombian acai has higher proportions of delphinidin, cyanidin (cyanidin-3-glucoside), and ferulic acid with high antioxidant activity [14, 15]. Proanthocyanidins were detected from acai seed aqueous extract, as well as their bioactivity (antioxidant and cytotoxic activities) depending strongly on their phenolic profile. However, other nonphenolic compounds may be involved in their antioxidant activity . Moreover, in healthy women, it has been observed that the consumption of acai pulp improves the concentration of antioxidant cellular enzymes and serum biomarkers increasing catalase activity, total antioxidant capacity, and the reduction of reactive oxygen species and carbonyl protein concentration .
Among other studies, acai showed antiparasitic activity against L. infantum and L. amazonensis without cytotoxic effects to the host cell , reduction of early carcinogenesis in the colon of mice, mitigation of DNA damage induced by azoxymethane , antitumorigenic potential in the MCF-7 cell line , reduction in selected markers of metabolic disease risk in overweight adults , protection against renal damage in diabetic rats , inhibition of urinary bladder carcinogenesis in mice , improvement of cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction , and prevention of oxidative damage in the brain of rats .
3.3. Myrciaria dubia (HBK) (McVaugh)
Its common names are camu-camu, caçari, arazá de agua, guayabo, guayabito, or guapuro blanco. It grows near the river and lake margins (Figure 3). Its high phenolic and vitamin C concentration contributes to a high antioxidant capacity and the consequent health benefits [26, 27].
Camu-camu is a spherical fruit (with a diameter and length of approximately 1.0-3.2 cm and 1.2-2.5 cm, respectively) . Polyphenolic compounds, antioxidant concentration, and antioxidant capacity depend on their maturity state . Before harvest, carotenoids, flavonoids, and anthocyanins, as well as vitamin C, are in higher concentrations. When the fruit ripens, ascorbic acid concentration decreases, while anthocyanin, flavonol, and flavanol content, as well as the antioxidant capacity, increased [26, 29].
Chemical analysis by HPLC identified the presence of catechin, delphinidin 3-glucoside, cyanidin 3-glucoside, ellagic acid, and rutin. Other phenolic compounds were also present such as flavan-3-ol, flavonol, flavanone, and ellagic acid derivatives. Acid hydrolysis of phenolic fraction revealed the presence mainly of gallic and ellagic acids, which suggests that this fruit has important quantities of hydrolyzed tannins (gallotannins and/or ellagitannins) .
It has been observed in rats with diabetes type 1 that camu-camu frozen pulp extracts attenuate hyperlipidemia and lipid peroxidation. This could be due to the presence of flavonoids such as quercetin and myricetin that would be contributing to avoid oxidative damage, relieving diabetic complications in this animal model . Camu-camu juice has an antigenotoxic effect in acute, subacute, and chronic treatments in blood cells of mice. This effect is being observed only in ex vivo studies, with more significant results in juice acute administration, without toxic effects or posttreatment death . Moreover, compounds such as ellagitannins, ellagic acid, quercetin glucosides, syringic acid, and myricetin could be the main reason for a protection effect against microvascular complications (associated with diabetes type 2) and against some bacterial infections; in vitro evaluation showed antihyperglycemic, antihypertensive, antimicrobial, and cell rejuvenation activities . Camu-camu residues have also demonstrated antioxidant, antimicrobial, and antienzymatic activities .
3.4. Solanum sessiliflorum (Dunal, 1814)
Its name is cocona and it is an herbaceous shrub whose fruits vary from almost spherical or ovoid to oval. With a 4 to 12 cm width and a 3 to 6 cm length and a 240 to 250 g weight, it has a color from yellow to reddish (Figure 4). Their hull is soft and is surrounded by a thick, yellow, and watery mesocarp; it has an unusual taste, highly acid. It is consumed in salads and juices . Cocona is slightly known mainly due its small-scale production . However, local population consumes it very frequently as hypocholesterolemic and hypoglycemic remedies and for skin disease treatment [36, 37].
Its components include the presence of p-coumaric acid, p-hydroxydihydrocoumaric acid, naringenin, methyl salicylate, long-chain hydrocarbons, fatty acids, and their methyl and ethyl esters. Some of these compounds accumulate only in fruit epicarp. Chromatographic profile comparison between volatile compounds and different morphotypes (oval, small round, and large round) showed chemical differences; the oval morphotype exhibits greater chemical complexity in terms of volatile and nonvolatile metabolites. Furthermore, cytotoxic, genotoxic, and antigenotoxic potential was evaluated in vivo, observing a noncytotoxic effect on bone marrow cells and a nongenotoxic effect on Wistar rats. Cocona antioxidant capacity may contribute to the antigenotoxic effects [38, 39]. Finally, cocona flour administration showed a reduction of total cholesterol concentration, low-density lipoprotein (LDL-c), and liver cholesterol and increasing cholesterol and high-density lipoprotein (HDL-c) fecal excretion in hypercholesterolemic rats .
3.5. Theobroma grandiflorum (Willd. ex Spreng.) (K. Schum, 1886)
It is a tree that reaches 15-20 m high; it belongs to the Sterculiaceae family . Its fruits have different shapes (oblong, round oval), weighing between 200 g and 4000 g (Figure 5) . It is known as copoazú and belongs to the Theobroma genus, like cocoa, and is considered as one of the most popular fruits in the Amazonian market .
From copoazú almonds, it is obtained as a cocoa-like liquor, with improved characteristics on unsaturated fatty acid percentages and a smooth and pleasant flavor. It has active antioxidant substances, low percentage of theobromine, and high content of linoleic and oleic unsaturated fatty acids. It is considered a suitable product for cosmetic, chocolate, beverage, liquor, and food industries . Its main components in pulp were detected such as volatile compounds: 24 esters, 13 terpenes, 8 alcohols, 4 carbonyls, 4 acids, 2 lactones and phenol, ethyl butanoate, ethyl hexanoate, and linalool .
Polyphenols derived from copoazú were studied evaluating the distribution and metabolism in the gastrointestinal tract of mice and the microbial metabolic conversion of a unique combination of flavonoids (flavan-3-ols, procyanidins, and flavones). These compounds are accumulated mainly in the stomach and small intestine where they could exert local effects. Procyanidin microbial metabolism was different from cocoa that contains procyanidin too . Further, copoazú and cocoa liquors were chronically provided to diabetic rats with streptokin. Copoazú liquor improves their lipid profile and antioxidant status, which could suggest a superior effect of the cocoa liquor .
3.6. Mauritia flexuosa L.f. (1782)
It is commonly known as canangucha, buriti, or moriche palm. It is considered the most abundant native palm that grows naturally in the Brazilian Amazon biome. Its fruit is highly nutritious with a yellow-orange pulp (Figure 6) and bittersweet taste. Its endocarp is surrounded by a spongy material made of starch and oil, with a hard skin, and contains a small reddish-brown scale-like fruit . It is possible to extract oil from its pulp, whose main components are palmitic (18.7%), stearic (1.5%), oleic (76.7%), linoleic (1.5%), linolenic (0.7%), and arachidic acid (0.5%) .
The moriche plant has phenolic compounds mainly flavonoids and glycosylated anthocyanins like the following: catechin, caffeic acid, chlorogenic acid, quercetin, naringenin, myricetin, vitexin, scoparin, rutin, cyanidin-3-rutinoside, cyanidin-3-glucoside, epicatechin, and kaempferol . On the other hand, the fruits show a reasonable amount of phenolic compounds, carotenoids (with predominance of β-carotenes), and antioxidant activity, which confirms the functional potential of moriche . Fruit pulp extracts showed six phenolic acids: p-coumaric, ferulic, caffeic, protocatechuic, chlorogenic, and quinic. Quinic acid is much more abundant than other phenolic acids in pulp; extracts also show seven kinds of flavonoids such as catechin, epicatechin, apigenin, luteolin, myricetin, kaempferol, and quercetin . In leaves, tricine-7-O-rutinoside, apigenin-6-C-arabinoside, 8-C-glucoside (isoschaftoside), kaempferol-3-O-rutinoside (nicotiflorine), quercetin-3-O-rutinoside (rutin), luteolin-8-C-glucoside (orientin), and luteolin-6-C-glucoside (isoorientin) were identified . Leaf extract revealed its great ability to inhibit food pathogens, like Pseudomonas aeruginosa, and a moderate antimicrobial activity when applied in fruits .
3.7. Plukenetia volubilis L.
It is a domesticated grapevine known also as sacha inchi, sacha yuchi, sacha yuchiqui, mountain peanuts, wild peanuts, or inca peanuts among others. It grows in warm climates, at high altitude in the Andean rainforest to the Peruvian Amazon lowlands (Figure 7). Due to its oil content, it is used as food supplement, in skin care, and for wound treatment, insect bites, and skin infections .
The most studied and interesting fraction of this fruit is its oil. Fruit seeds are a suitable oil source (35-60%) rich in omega 3 and 6, whose composition varies according to seed varieties. Found were significant contents of α-linolenic acid and a low linolenic acid/linoleic acid ratio, as well as considerable amounts of tocopherols (γ- and δ-tocopherols), phytosterols (β-sitosterol and stigmasterol), and phenolic compounds like ferulic acid. However, no correlations have been found between hydrophilic and lipophilic bioactive compounds and antioxidant capacity. It suggests a complex interaction of different antioxidant compounds with different action modes. Although there are few studies on the sacha inchi oil effects on health, there are evidences that it could act by improving the lipid profile . Regarding its use for skin care, sacha inchi oil was very active as a nonstick (preventive) in keratinocytes and in the detachment of Staphylococcus aureus on the adherence to in vitro human skin explants .
3.8. Bactris gasipaes H. B. Kunth
It is an Amazonian palm grown mainly for fruit production (Figure 8), known as chontaduro, pejiballe, acana, or pupunha . The chontaduro fruit has considerable concentration of proteins and oil , with an important content of linoleic and linolenic polyunsaturated fatty acids , as well as β-carotenes .
Chontaduro flour residues contain different types of carotenoids: violaxanthin, lutein, zeaxanthin, 15-cis β-carotene, 13-cis β-carotene, all-trans β-carotene, 9-cis β-carotene, and α-carotene, as the main carotenoid pigment. Retinol equivalent values found for chontaduro cooked fruit (traditional consumption form) and flour are higher than those reported for popular products such as tomato and papaya [58, 59]. Chontaduro flour carbohydrates are predominantly composed of insoluble fiber, highly esterified homogalacturonan (70% of esterification). It contains linear methyl and minor portions of xylogalacturonan and rhamnogalacturonan that may promote health benefits. Although not very well documented in the literature, probably refer to their antioxidant capacity and their nutritional value since their protein contains eight essential amino acids .
3.9. Paullinia cupana Kunth (1823)
This climbing shrub, better known as guarana, is rich in vitamins and stimulants such as caffeine; so, it is used mainly for consumption as beverage (Figure 9). It is produced mainly in the Brazilian states of Amazonas and Bahia, and approximately 70% of its production is used in soft and energy drink industries . Its seeds are used to produce guarana powder, which is consumed mainly due to its stimulating activity . The main reason so far to study guarana is its caffeine content, and this probably will continue due to the high demand of this alkaloid in the pharmaceutical and cosmetic industries. Semipurified guarana extract shows antidepressant and panicolytic effects . Guarana seed extracts present antimicrobial activity against Escherichia coli, Pseudomonas fluorescens, Bacillus cereus, and spoilage fungi such as Aspergillus niger, Trichoderma viride, and Penicillium cyclopium .
All guarana seed extracts have antioxidant activity with high amounts of total phenolic compounds like catechins, such as epicatechin, catechin, and epicatechin gallate. Due to their high antioxidant, antibacterial, and antifungal activities, guarana extracts have a promising potential as natural antioxidants in food, cosmetic, and pharmaceutical industries .
The presence of dietary fiber, including pectic and hemicellulose polysaccharides has been reported, and a homogalacturonan with rhamnogalacturonan and xylans has also been isolated and characterized. Pectic polysaccharides and methanolic extract exhibited antioxidant activity, and part of the possible antioxidant effects of guarana could be attributed to their pectic component .
4. Antioxidant Capacity of Native Amazonian Fruits
In summary, most of the compounds with functional activity correspond to compounds with antioxidant activity; Table 2 shows the different methods used in the references examined in the present mini review. However, the comparisons are extremely complicated so it would be more appropriate to review clinical studies performed on animals, but unfortunately, to date, there are very few of them. The antioxidant capacity methods were DPPH, FRAP, TEAC, ABTS, and ORAC. Comparison of antioxidant capacity between fruits should be made only when the conditions (method, solvent, sampling, expression of results, etc.) analyzed are the same; therefore, results are not comparable with a great disadvantage that presents to compare the antioxidant capacities of various fruits.
According to numerous authors, many Amazonian fruits are an adequate source of multiple compounds with potential health benefits, mainly antioxidant effects, which has also been proven through numerous studies such as those detailed in this mini review. However, among its differences in composition, quality, and insufficient in vivo tests, scientific evidence offers challenges and great opportunities in different areas of research (toxicology, food safety, food technology, and processing). Therefore, new trends in functional foods should be conducted considering the enormous potential of these Amazonian fruits in human health.
Conflicts of Interest
The authors declare no conflict of interest.
L. C. Neves, J. M. Tosin, R. M. Benedette, and L. Cisneros-Zevallos, “Post-harvest nutraceutical behaviour during ripening and senescence of 8 highly perishable fruit species from the Northern Brazilian Amazon region,” Food Chemistry, vol. 174, pp. 188–196, 2015.View at: Publisher Site | Google Scholar
H. Rogez, R. Buxant, E. Mignolet, J. N. S. Souza, E. M. Silva, and Y. Larondelle, “Chemical composition of the pulp of three typical Amazonian fruits: araça-boi (Eugenia stipitata), bacuri (Platonia insignis) and cupuaçu (Theobroma grandiflorum),” European Food Research and Technology, vol. 218, no. 4, pp. 380–384, 2004.View at: Publisher Site | Google Scholar
R. Rodríguez Sandoval and P. Bastidas Garzón, “Evaluating the cooking process for obtaining hard candy from araza (Eugenia stipitata) pulp,” Ingeniería e Investigación, vol. 29, pp. 35–41, 2009.View at: Google Scholar
J. P. L. Aguiar, “Araçá-boi (eugenia stiptata, mcvaug) - aspectos e dados preliminares sobre a sua composição química,” Acta Amazonica, vol. 13, no. 5-6, pp. 953-954, 1983.View at: Publisher Site | Google Scholar
I. A. Neri-Numa, L. B. Carvalho-Silva, J. P. Morales et al., “Evaluation of the antioxidant, antiproliferative and antimutagenic potential of araçá-boi fruit (Eugenia stipitata Mc Vaugh — Myrtaceae) of the Brazilian Amazon Forest,” Food Research International, vol. 50, no. 1, pp. 70–76, 2013.View at: Publisher Site | Google Scholar
G. A. Garzón, C.-E. Narváez-Cuenca, R. E. Kopec, A. M. Barry, K. M. Riedl, and S. J. Schwartz, “Determination of carotenoids, total phenolic content, and antioxidant activity of Arazá (Eugenia stipitata McVaugh), an Amazonian fruit,” Journal of Agricultural and Food Chemistry, vol. 60, no. 18, pp. 4709–4717, 2012.View at: Publisher Site | Google Scholar
F. A. Cuellar, E. Ariza, C. Anzola, and P. Restrepo, “Research of antioxidant capacity of araza (Eugenia stipitata Mc Vaugh) during the ripening,” Revista Colombiana de Química, vol. 42, pp. 21–28, 2013.View at: Google Scholar
A. Guerrini, G. Sacchetti, A. Grandini, A. Spagnoletti, M. Asanza, and L. Scalvenzi, “Cytotoxic effect and TLC bioautography-guided approach to detect health properties of Amazonian Hedyosmum sprucei essential oil,” Evidence-Based Complementary and Alternative Medicine, vol. 2016, Article ID 1638342, 8 pages, 2016.View at: Publisher Site | Google Scholar
S. Casiglia, M. Bruno, M. Bramucci et al., “Kundmannia sicula (L.) DC: a rich source of germacrene D,” Journal of Essential Oil Research, vol. 29, no. 6, pp. 437–442, 2017.View at: Publisher Site | Google Scholar
I. Peluso, T. Magrone, D. Villaño Valencia, C. Y. O. Chen, and M. Palmery, “Antioxidant, anti-inflammatory, and microbial-modulating activities of nutraceuticals and functional foods,” Oxidative Medicine and Cellular Longevity, vol. 2017, Article ID 7658617, 2 pages, 2017.View at: Publisher Site | Google Scholar
F. Aguiar, V. Menezes, and H. Rogez, “Spontaneous postharvest fermentation of açai (Euterpe oleracea) fruit,” Postharvest Biology and Technology, vol. 86, pp. 294–299, 2013.View at: Publisher Site | Google Scholar
R. G. Costa, K. Andreola, R. de Andrade Mattietto, L. J. G. de Faria, and O. P. Taranto, “Effect of operating conditions on the yield and quality of açai (Euterpe oleracea Mart.) powder produced in spouted bed,” LWT - Food Science and Technology, vol. 64, no. 2, pp. 1196–1203, 2015.View at: Publisher Site | Google Scholar
M. Amsellem-Laufer, “Euterpe oleracea Martius (Arecaceae):Açaï,” Phytothérapie, vol. 13, no. 2, pp. 135–140, 2015.View at: Publisher Site | Google Scholar
B. A. Rojano, I. C. Z. Vahos, A. F. A. Arbeláez, A. J. M. Martínez, F. B. C. Correa, and L. G. Carvajal, “Polifenoles y actividad antioxidante del fruto liofilizado de palma naidi (Açai Colombiano) (Euterpe oleracea Mart),” Revista Facultad Nacional de Agronomía Medellín, vol. 64, pp. 6213–6220, 2011.View at: Google Scholar
G. A. Garzón, C. E. Narváez-Cuenca, J. P. Vincken, and H. Gruppen, “Polyphenolic composition and antioxidant activity of açai (Euterpe oleracea Mart.) from Colombia,” Food Chemistry, vol. 217, pp. 364–372, 2017.View at: Publisher Site | Google Scholar
L. Barros, R. C. Calhelha, M. J. R. P. Queiroz et al., “The powerful in vitro bioactivity of Euterpe oleracea Mart. seeds and related phenolic compounds,” Industrial Crops and Products, vol. 76, pp. 318–322, 2015.View at: Publisher Site | Google Scholar
P. O. Barbosa, D. Pala, C. T. Silva et al., “Açai (Euterpe oleracea Mart.) pulp dietary intake improves cellular antioxidant enzymes and biomarkers of serum in healthy women,” Nutrition, vol. 32, no. 6, pp. 674–680, 2016.View at: Publisher Site | Google Scholar
B. J. M. Da Silva, J. R. Souza-Monteiro, H. Rogez, M. E. Crespo-López, J. L. M. Do Nascimento, and E. O. Silva, “Selective effects of Euterpe oleracea (açai) on Leishmania (Leishmania) amazonensis and Leishmania infantum,” Biomedicine & Pharmacotherapy, vol. 97, pp. 1613–1621, 2018.View at: Publisher Site | Google Scholar
G. R. Romualdo, M. F. Fragoso, R. G. Borguini, M. C. P. de Araújo Santiago, A. A. H. Fernandes, and L. F. Barbisan, “Protective effects of spray-dried açaí (Euterpe oleracea Mart) fruit pulp against initiation step of colon carcinogenesis,” Food Research International, vol. 77, pp. 432–440, 2015.View at: Publisher Site | Google Scholar
D. F. Silva, F. C. B. Vidal, D. Santos et al., “Cytotoxic effects of Euterpe oleracea Mart. in malignant cell lines,” BMC Complementary and Alternative Medicine, vol. 14, no. 1, p. 175, 2014.View at: Publisher Site | Google Scholar
J. K. Udani, B. B. Singh, V. J. Singh, and M. L. Barrett, “Effects of Açai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: a pilot study,” Nutrition Journal, vol. 10, no. 1, pp. 45–51, 2011.View at: Publisher Site | Google Scholar
V. da Silva Cristino Cordeiro, G. F. de Bem, C. A. da Costa et al., “Euterpe oleracea Mart. seed extract protects against renal injury in diabetic and spontaneously hypertensive rats: role of inflammation and oxidative stress,” European Journal of Nutrition, vol. 57, no. 2, pp. 817–832, 2018.View at: Publisher Site | Google Scholar
M. F. Fragoso, M. G. Prado, L. Barbosa, N. S. Rocha, and L. F. Barbisan, “Inhibition of mouse urinary bladder carcinogenesis by açai fruit (Euterpe oleraceae Martius) intake,” Plant Foods for Human Nutrition, vol. 67, no. 3, pp. 235–241, 2012.View at: Publisher Site | Google Scholar
G. Zapata-Sudo, J. S. da Silva, S. L. Pereira, P. J. C. Souza, R. S. de Moura, and R. T. Sudo, “Oral treatment with Euterpe oleracea Mart. (açaí) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction,” BMC Complementary and Alternative Medicine, vol. 14, no. 1, p. 227, 2014.View at: Publisher Site | Google Scholar
F. de Souza Machado, J. Kuo, M. F. Wohlenberg et al., “Subchronic treatment with acai frozen pulp prevents the brain oxidative damage in rats with acute liver failure,” Metabolic Brain Disease, vol. 31, no. 6, pp. 1427–1434, 2016.View at: Publisher Site | Google Scholar
L. C. Neves, V. X. Silva, E. A. Chagas, C. G. B. Lima, and S. R. Roberto, “Determining the harvest time of camu-camu [Myrciaria dubia (H.B.K.) McVaugh] using measured pre-harvest attributes,” Scientia Horticulturae, vol. 186, pp. 15–23, 2015.View at: Publisher Site | Google Scholar
A. L. R. Souza, M. M. Pagani, M. Dornier, F. S. Gomes, R. V. Tonon, and L. M. C. Cabral, “Concentration of camu-camu juice by the coupling of reverse osmosis and osmotic evaporation processes,” Journal of Food Engineering, vol. 119, no. 1, pp. 7–12, 2013.View at: Publisher Site | Google Scholar
M. S. Akter, S. Oh, J. B. Eun, and M. Ahmed, “Nutritional compositions and health promoting phytochemicals of camu-camu (Myrciaria dubia) fruit: a review,” Food Research International, vol. 44, no. 7, pp. 1728–1732, 2011.View at: Publisher Site | Google Scholar
R. Chirinos, J. Galarza, I. Betalleluz-Pallardel, R. Pedreschi, and D. Campos, “Antioxidant compounds and antioxidant capacity of Peruvian camu camu (Myrciaria dubia (H.B.K.) McVaugh) fruit at different maturity stages,” Food Chemistry, vol. 120, no. 4, pp. 1019–1024, 2010.View at: Publisher Site | Google Scholar
A. E. de Souza Schmidt Gonçalves, C. Lellis-Santos, R. Curi, F. M. Lajolo, and M. I. Genovese, “Frozen pulp extracts of camu-camu (Myrciaria dubia McVaugh) attenuate the hyperlipidemia and lipid peroxidation of type 1 diabetic rats,” Food Research International, vol. 64, pp. 1–8, 2014.View at: Publisher Site | Google Scholar
F. C. da Silva, A. Arruda, A. Ledel et al., “Antigenotoxic effect of acute, subacute and chronic treatments with Amazonian camu-camu (Myrciaria dubia) juice on mice blood cells,” Food and Chemical Toxicology, vol. 50, no. 7, pp. 2275–2281, 2012.View at: Publisher Site | Google Scholar
A. Fujita, K. Borges, R. Correia, B. D. G. M. Franco, and M. I. Genovese, “Impact of spouted bed drying on bioactive compounds, antimicrobial and antioxidant activities of commercial frozen pulp of camu-camu (Myrciaria dubia Mc. Vaugh),” Food Research International, vol. 54, no. 1, pp. 495–500, 2013.View at: Publisher Site | Google Scholar
J. C. S. De Azevêdo, A. Fujita, E. L. de Oliveira, M. I. Genovese, and R. T. P. Correia, “Dried camu-camu (Myrciaria dubia H.B.K. McVaugh) industrial residue: a bioactive-rich Amazonian powder with functional attributes,” Food Research International, vol. 62, pp. 934–940, 2014.View at: Publisher Site | Google Scholar
D. F. da Silva Filho, J. S. de Andrade, C. R. Clement, F. M. Machado, and H. Noda, “Correlações fenotípicas, genéticas e ambientais entre descritores morfológicos e químicos em frutos de cubiu (Solanum sessiliflorum Dunal) da amazônia1,” Acta Amazonica, vol. 29, no. 4, pp. 503–511, 1999.View at: Publisher Site | Google Scholar
C. Agudelo, M. Igual, P. Talens, and N. Martínez-Navarrete, “Optical and mechanical properties of cocona chips as affected by the drying process,” Food and Bioproducts Processing, vol. 95, pp. 192–199, 2015.View at: Publisher Site | Google Scholar
J. Salick, “Cocona (Solanum sessiliflorum Dunal), an overview of productions and breeding potentials,” in International Symposium on New Crops for Food Industry, pp. 125–129, University Southampton, Southampton, 1989.View at: Google Scholar
M. A. Pardo, “Efecto de Solanum sessiliflorum dunal sobre el metabolismo lipídico y de la glucosa,” Ciencia e Investigación, vol. 7, pp. 43–48, 2004.View at: Google Scholar
L. C. Hernandes, A. F. Aissa, M. R. d. Almeida et al., “In vivo assessment of the cytotoxic, genotoxic and antigenotoxic potential of maná-cubiu (Solanum sessiliflorum Dunal) fruit,” Food Research International, vol. 62, pp. 121–127, 2014.View at: Publisher Site | Google Scholar
J. E. C. Cardona, L. E. Cuca, and J. A. Barrera, “Determination of some secondary metabolites in three ethnovarieties of cocona (Solanum sessiliflorum Dunal),” Revista Colombiana de Química, vol. 40, pp. 185–200, 2011.View at: Google Scholar
J. R. P. Maia, M. C. Schwertz, R. F. S. Sousa, J. P. L. Aguiar, and E. S. Lima, “Efeito hipolipemiante da suplementação dietética com a farinha do cubiu (Solanum sessiliflorum Dunal) em ratos hipercolesterolêmicos,” Revista Brasileira de Plantas Medicinais, vol. 17, no. 1, pp. 112–119, 2015.View at: Publisher Site | Google Scholar
C. E. Quijano and J. A. Pino, “Volatile compounds of copoazú (Theobroma grandiflorum Schumann) fruit,” Food Chemistry, vol. 104, no. 3, pp. 1123–1126, 2007.View at: Publisher Site | Google Scholar
S. d. N. Melo Ramos, W. Danzl, G. Ziegleder, and P. Efraim, “Formation of volatile compounds during cupuassu fermentation: influence of pulp concentration,” Food Research International, vol. 87, pp. 161–167, 2016.View at: Publisher Site | Google Scholar
H. R. d. M. Barros, R. García-Villalba, F. A. Tomás-Barberán, and M. I. Genovese, “Evaluation of the distribution and metabolism of polyphenols derived from cupuassu (Theobroma grandiflorum) in mice gastrointestinal tract by UPLC-ESI-QTOF,” Journal of Functional Foods, vol. 22, pp. 477–489, 2016.View at: Publisher Site | Google Scholar
J. Criollo, D. Criollo, and A. S. Aldana, “Fermentación de la almendra de copoazú (Theobroma grandiflorum [Willd. ex Spreng.] Schum.): evaluación y optimización del proceso,” Corpoica Ciencia y Tecnología Agropecuaria, vol. 11, no. 2, p. 107, 2010.View at: Publisher Site | Google Scholar
T. B. De Oliveira and M. I. Genovese, “Chemical composition of cupuassu (Theobroma grandiflorum) and cocoa (Theobroma cacao) liquors and their effects on streptozotocin-induced diabetic rats,” Food Research International, vol. 51, no. 2, pp. 929–935, 2013.View at: Publisher Site | Google Scholar
J. T. Milanez, L. C. Neves, R. C. Colombo, M. Shahab, and S. R. Roberto, “Bioactive compounds and antioxidant activity of buriti fruits, during the postharvest, harvested at different ripening stages,” Scientia Horticulturae, vol. 227, pp. 10–21, 2018.View at: Publisher Site | Google Scholar
R. Pereira Lima, P. T. Souza da Luz, M. Braga et al., “Murumuru (Astrocaryum murumuru Mart.) butter and oils of buriti (Mauritia flexuosa Mart.) and pracaxi (Pentaclethra macroloba (Willd.) Kuntze) can be used for biodiesel production: physico-chemical properties and thermal and kinetic studies,” Industrial Crops and Products, vol. 97, pp. 536–544, 2017.View at: Publisher Site | Google Scholar
H. H. F. Koolen, F. M. A. da Silva, F. C. Gozzo, A. Q. L. de Souza, and A. D. L. de Souza, “Antioxidant, antimicrobial activities and characterization of phenolic compounds from buriti (Mauritia flexuosa L. f.) by UPLC-ESI-MS/MS,” Food Research International, vol. 51, no. 2, pp. 467–473, 2013.View at: Publisher Site | Google Scholar
T. L. N. Candido, M. R. Silva, and T. S. Agostini-Costa, “Bioactive compounds and antioxidant capacity of Buriti (Mauritia flexuosa L.f.) from the Cerrado and Amazon biomes,” Food Chemistry, vol. 177, pp. 313–319, 2015.View at: Publisher Site | Google Scholar
G. A. Bataglion, F. M. A. da Silva, M. N. Eberlin, and H. H. F. Koolen, “Simultaneous quantification of phenolic compounds in buriti fruit (Mauritia flexuosa L.f.) by ultra-high performance liquid chromatography coupled to tandem mass spectrometry,” Food Research International, vol. 66, pp. 396–400, 2014.View at: Publisher Site | Google Scholar
D. M. De Oliveira, E. P. Siqueira, Y. R. F. Nunes, and B. B. Cota, “Flavonoids from leaves of Mauritia flexuosa,” Revista Brasileira de Farmacognosia, vol. 23, no. 4, pp. 614–620, 2013.View at: Publisher Site | Google Scholar
F. Garmendia, R. Pando, and G. Ronceros, “Efecto del aceite de sacha inchi (Plukenetia volúbilis L) sobre el perfil lipídico en pacientes con hiperlipoproteinemia,” Revista Peruana de Medicina Experimental y Salud Pública, vol. 28, no. 4, pp. 628–632, 2012.View at: Publisher Site | Google Scholar
G. Gonzalez-Aspajo, H. Belkhelfa, L. Haddioui-Hbabi, G. Bourdy, and E. Deharo, “Sacha inchi oil (Plukenetia volubilis L.), effect on adherence of Staphylococus aureus to human skin explant and keratinocytes in vitro,” Journal of Ethnopharmacology, vol. 171, pp. 330–334, 2015.View at: Publisher Site | Google Scholar
A. S. Heringer, D. A. Steinmacher, H. P. F. Fraga et al., “Improved high-efficiency protocol for somatic embryogenesis in peach palm (Bactris gasipaes Kunth) using RITA® temporary immersion system,” Scientia Horticulturae, vol. 179, pp. 284–292, 2014.View at: Publisher Site | Google Scholar
E. E. Haro, J. A. Szpunar, and A. G. Odeshi, “Dynamic and ballistic impact behavior of biocomposite armors made of HDPE reinforced with chonta palm wood (Bactris gasipaes) microparticles,” Defence Technology, vol. 14, no. 3, pp. 238–249, 2018.View at: Publisher Site | Google Scholar
J. Restrepo, J. A. Estupiñán, and A. J. Colmenares, “Estudio comparativo de las fracciones lipídicas de Bactris gasipaes Kunth (chontaduro) obtenidas por extracción soxhlet y por extracción con CO2 supercrítico,” Revista Colombiana de Química, vol. 45, no. 1, pp. 5–9, 2016.View at: Publisher Site | Google Scholar
F. A. Espinosa-Pardo, J. Martinez, and H. A. Martinez-Correa, “Extraction of bioactive compounds from peach palm pulp (Bactris gasipaes) using supercritical CO2,” The Journal of Supercritical Fluids, vol. 93, pp. 2–6, 2014.View at: Publisher Site | Google Scholar
C. Rojas-Garbanzo, A. M. Pérez, J. Bustos-Carmona, and F. Vaillant, “Identification and quantification of carotenoids by HPLC-DAD during the process of peach palm (Bactris gasipaes H.B.K.) flour,” Food Research International, vol. 44, no. 7, pp. 2377–2384, 2011.View at: Publisher Site | Google Scholar
G. J. Basto, C. W. P. Carvalho, A. G. Soares et al., “Physicochemical properties and carotenoid content of extruded and non-extruded corn and peach palm (Bactris gasipaes, Kunth),” LWT - Food Science and Technology, vol. 69, pp. 312–318, 2016.View at: Publisher Site | Google Scholar
B. C. Bolanho, E. D. G. Danesi, and A. D. P. Beleia, “Carbohydrate composition of peach palm (Bactris gasipaes Kunth) by-products flours,” Carbohydrate Polymers, vol. 124, pp. 196–200, 2015.View at: Publisher Site | Google Scholar
F. C. Schimpl, J. F. da Silva, J. F. C. Gonçalves, and P. Mazzafera, “Guarana: revisiting a highly caffeinated plant from the Amazon,” Journal of Ethnopharmacology, vol. 150, no. 1, pp. 14–31, 2013.View at: Publisher Site | Google Scholar
N. Dalonso and C. L. d. O. Petkowicz, “Guarana powder polysaccharides: characterisation and evaluation of the antioxidant activity of a pectic fraction,” Food Chemistry, vol. 134, no. 4, pp. 1804–1812, 2012.View at: Publisher Site | Google Scholar
T. Klein, R. Longhini, M. L. Bruschi, and J. C. P. de Mello, “Microparticles containing Guaraná extract obtained by spray-drying technique: development and characterization,” Revista Brasileira de Farmacognosia, vol. 25, no. 3, pp. 292–300, 2015.View at: Publisher Site | Google Scholar
L. Majhenič, M. Škerget, and Ž. Knez, “Antioxidant and antimicrobial activity of guarana seed extracts,” Food Chemistry, vol. 104, no. 3, pp. 1258–1268, 2007.View at: Publisher Site | Google Scholar

domain: literature


SAN FRANCISCO (MarketWatch) -- IndyMac Bancorp said on Thursday that it's laying off about 400 staffers, or roughly 4% of its workforce, to stay competitive in a tough mortgage market.
IndyMac will take a $6.5 million pretax charge in the third quarter because of the layoffs, but cost savings in the second half of 2007 will more than make up for this, according to an e-mail IndyMac Chief Executive Mike Perry sent to employees. The company posted a copy of the e-mail on its blog, www.theimbreport.com. Perry said that the company expects $30 million in annual cost savings from the move.
The cuts are mainly in the company's mortgage operations and IT departments. Perry commented that the move was "painful" and that IndyMac
"However, we have also said that there could be no absolute guarantees that we would always be able to avoid layoffs if market conditions continued to erode," he added. "The reality is that the mortgage market continues to be very tough right now, and we recognize that we must take action to protect our business and remain competitive."
Industry-loan volumes and profit margins continue to be under pressure, according to Perry.
IndyMac's dollar-loan volume fell 12% in the second quarter, compared with the first three months of 2007, the executive said. In terms of the number of loan units offered, volume fell 17% because the company stopped offering so-called 80/20 piggybank mortgages, in which the borrower has two loans stacked on top of each other, Perry indicated.
The company is now favoring first-lien, higher loan-to-value offerings with mortgage insurance, he said.
"While recently our pipeline has been recovering, we concluded that we needed to both 'right-size' our workforce to our current volumes, and also be very 'hard-nosed' in redesigning our processes in our drive to become 'the' low-cost provider in the mortgage industry," Perry wrote in the e-mail.


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Deb at Paxton Valley Folkart is having a fun giveaway to celebrate her first year of blogging. Just click on her cute sign to take you to her sign up page. It ends July 27th.
This fabulous witch is a giveaway at Rusty Thimble. Brenda does fabulous work and you will not want to miss out on this giveaway. This will end on her Birthday July 15. Click on the photo above to take you to her blog page.
This wonderful scarecrow is the giveaway prize at Crafty Stitchers. Cyndy is celebrating her Birthday and this ends July 15th. Click on the photo to take you right to her page.
Also check my side bar for other fun and creative giveaways!
Now I want to win all of these but being the nice gal I am I will share just how wonderfully talented all these gals are. Just tell them that I sent you!!
Enjoy and good luck to me--I mean all of us!

domain: entertainment


Who Are We
The Blue Symphony Orchestra is the university's premier student-led orchestra, cultivating music appreciation in all its members and seeking to share this value within and beyond the LS community.
Why should you join us?
- ✔ We offer something for everyone passionate about music. For both instrumentalists and non-instrumentalists, Blue Symphony offers its members the opportunity to develop themselves as musicians and music listeners. From performing to concert production to design, Blue Symphony has something for everyone, even without any prior orchestral experience.
Our Yearly Projects
Annual Year-End Concert
As Blue Symphony's flagship project for the year, the year-end concert highlights the best of the best from all aspects of Blue Symphony. From performance to production, this concert is a culmination of a year's worth of preparation and puts Blue Symphony's best foot forward.
Blue Symphony's Showcase is another one of Blue Symphony's concerts that features smaller chamber ensembles to perform different original arrangements by our members. The Showcase helps highlight different individual members' skills while playing in smaller ensembles.


Automation, Equipment, Engineering, Weldments, Tooling, Custom, Machine Mechanical, Feeder Bowl, Robotic, Cells, Sheet-Metal,Enclosures, Cabinets, Workstations, Presentation, Rotary, Indexer, Frames, Ergomatic, Products, Brackets, Fixtures, Lift Assist, SolidWorks, AutoCAD, Designing, Drafting
Fixtures & Sheet-Metal
welcome to agius automation
Agius Automation, Top Product Design is a solution provider, cost effective, efficient, and highly reliable design and build service dealing with a large spectrum of industries and markets. We have been providing our customers with solutions for many years.
Our staff of experienced designers are ready to bring your visions to reality. Utilizing our dynamic in-house design facility we can provide you with a solution that meets your specific requirements.
Agius Automation, Top Product Design can assure that the end result will be quality and satisfaction.
Agius Automation Top Product Design mechanical automation testing machines fixtures sheet-metal
MECHANICAL automation -- PRODUCT DESIGN


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In all, Tuesday’s figures were a 17 percent decline from the premiere. In the 18-to-49-year-old demographic vital to advertisers, “Roseanne” notched a 3.9 rating, a 25 percent decline.
The loss, however, was in line with what executives at ABC and rival networks expected. And at a moment when the number of live viewers is plummeting, the figure suggests that a sizable audience is willing to watch TV the old-fashioned way.
In conversations on Tuesday, network executives said that if the second week of “Roseanne” experienced a decline in ratings of around 15 percent, ABC should still count it as a success. Stomachs were likely to churn at ABC’s Burbank, Calif., headquarters only if the show lost more than 25 percent of its initial audience.
Other recent revivals have experienced significant ratings losses once the novelty of their returns faded. In September, NBC’s “Will & Grace” lost 30 percent of its audience from its first week to its second. The show has continued to bleed viewers, but its ratings have stayed strong enough to make it a top 10 program. In 2016, Fox’s “The X-Files” lost 40 percent of its audience for its second episode. On Showtime, “Twin Peaks” experienced a decline of more than 50 percent between its first and second weeks.
The robust return of “Roseanne” has made the show and its namesake star political lightning rods. Fox News pundits joined Mr. Trump in hailing the success of the “Roseanne” premiere as a victory of their own. Some viewers on the left have expressed misgivings about supporting the show. And there were hot-take commentators who argued that “Roseanne” is surprisingly subversive, with more nuanced politics than either its ardent fans or its vocal detractors have acknowledged.
The third episode was about a generational parenting conflict that pitted Roseanne’s stricter, more traditional style against the looser, hands-off approach of her daughter Darlene.
A wild card factor is how much of a ratings drop will come in the show’s third week. Will “Roseanne” suffer mild, 5-to-10-percent declines as it moves closer to its ninth and final episode? Or will the falloff be steeper?
To make matters more complicated, Ms. Barr has her Twitter feed back.
Two months before the show premiered, she was not much of a presence on Twitter. She said her family had taken her password away, and she mentioned that she did not “want it to overshadow the show.”
But in recent weeks, Ms. Barr has been posting frequently on Twitter, and it did not take long for her to stir up controversy. Over the weekend, she seemed to endorse a fringe conspiracy theory known as “The Storm,” which suggests that Mr. Trump is breaking up child sex-trafficking rings involving Democratic politicians.
The message, which was later deleted, raised questions about whether Ms. Barr might eventually cause a revolt among viewers or advertisers, a cause for some concern among ABC executives, who have publicly backed their reborn star.
“You can’t control Roseanne Barr,” Ben Sherwood, the president of Disney and ABC’s television group, said in an interview last week. “Many who have tried have failed. She’s the one and only.”
The “Roseanne” reboot came out of a strategy hatched at ABC after Mr. Trump’s victory in November 2016. The goal was to increase the network’s appeal to Middle America. The premiere episode more than doubled ABC’s internal ratings estimates, and it performed best in heartland cities that do not usually light up the Nielsen meters.
If the show continues to deliver strong numbers, it could help take ABC out of last place among the four major broadcast networks.


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The Art League of Ocean City, located in the Ocean City Center for the Arts on 94th street bayside, is one of Ocean City’s hidden jems. The art center’s five galleries display new exhibits of regional and local artists which rotate monthly, so whenever you stop in, you can expect to see something different and exciting.
Exhibits kick off with an opening reception from 5-7 p.m. on the first Friday of each month. The receptions, as with all of the Art League’s activities, are open to the public.
Everything’s in bloom this week outside and inside the Art League. You’ll notice there’s a definite fragrance in the air as soon as you step inside…
Debra Howard: Fragrance
Thaler Gallery — In the main gallery this month is an interactive exhibit that not only involves using your sense of sight, but your sense of smell, too. Debra Howard exhibits 23 fragrance-inspired paintings, each with a vial of fragrance to go along with it. Visitors can choose an essential oil vial, enhale the fragance and see if they can match the fragrance with the painting, or just take it one-by-one as they walk around the gallery. Coffee beans are available so guests can start fresh between fragances. For anyone who wishes to learn more about how our brains respond to fragrance, and about Howard’s art in general, she will be presenting a free Artist Talk at the Art League on May 5.
Debra Howard spent her childhood in Miami, Florida, where she first discovered her love affair with color, light, painting, and sailing. She studied at Ringling School of Art in Sarasota, and began her career in San Francisco where she opened her first illustration studio. After 17 years as a successful illustrator in various cities, she closed her studio to concentrate on fine art painting. Debra is an award winning plein-air artist with a passionate collector base.
“Come to Your Senses” Group Show
Galleria — “Come to Your Senses” is an all media group show inspired by the five senses. Judge: Angela Herbert-Hodges.
John Iampieri Screen Painting
Studio E — Anyone familiar with the neighborhoods of East Baltimore has seen the hand-painted screens that once filled nearly every window and door of the long blocks of brick and formstone rowhouses. Painted screens are an authentic Baltimore urban folk art, created, displayed, and beloved there since 1913.
Screen painter John Iampieri, formerly of Baltimore and now of Bishopville, is the artist in residence for the month of May. A member of the Baltimore Painted Screen Society, he is a roster member with MSAC and Young Audiences of Maryland, and a teacher in schools throughout Maryland, Virginia, and Delaware.
The artist has invited the public to contribute to the screen paintings. The open painting sessions are scheduled for First Friday, May 4, from 5-7 p.m.; Wednesday, May 23, from 1 – 4 p.m.; Friday, May 25, from 10 a.m. – 3 p.m.; and Tuesday, May 29, from 10 a.m. – 3 p.m. Anyone who wishes to participate or watch the work is welcome to walk in.
Spotlight gallery — “Environmental Visions” showcases the works of Salisbury University Environmental Studies students. Professor Charlie Ewers teaches two courses for the Environmental Studies Department at SU: ENVR 205 (Art, Nature, Culture) looks at environmental issues from the perspective of the humanities, and ENVR 460 (The Bay in Words and Pictures) is a photojournalism course on Chesapeake-related topics.
One of the term projects for ENVR 205 centers on nature photography—students must take at least one picture a day for 30 consecutive days, make prints of their best four images and write an essay describing the process. In ENVR 460, the class compiles an online magazine of photo-illustrated feature stories.
Featured in the spotlight gallery for the month of May will be a selection of images curated by Charlie Ewers, poster-size prints on foamcore board and a looping slide show.
Artisan Showcase: Joy Galicinao
In the artisan showcase this month is the work of Joy Galicinao, an aromatherapist and jeweler who has been creating jewelry for over 25 years, working with semi-precious metals and stones. A certified aromatherapist, Galicinao began melding her two passions this past year and focuses on creating jewelry for the personal diffusion of essential oils. As an aromatherapist, she focuses on creating blends that target therapeutic, emotional and energetic needs, and as a jeweler, she focuses on creating unique jewelry for aromatic diffusion.


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An alert has now been issued in Dehradun, Haridwar, and Udhamsinghnagar districts of Uttarakhand as a precaution in wake of the possibility of pro-Khalistan leader Amritpal Singh entering the state, the state’s Director General of Police Ashok Kumar said.
The DGP further said that intensive checking has been going on at the borders of all three districts as well as the neighboring areas.
He also highlighted that these three districts have been affected by terrorism in the 90s.
Punjab’s Inspector General of Police (IGP), Headquarters, Sukhchain Singh Gill confirmed that a total of 207 persons have been arrested so far for disrupting peace and harmony in the state.
''Out of the arrested persons, 30 have been found in substantive criminal activities. While the others are under preventive arrest,'' he added.
He also said that the police are carrying on thorough screening of these arrested persons and they will shortly release them from police custody.
The IGP also said that the operation was launched on the directions of Chief Minister Bhagwant Mann to prevent the innocent youth of the state from falling prey to the Anti-National Forces that influence people to take up weapons against authorities while demanding their needs.
As per the IGP, Baljeet Kaur was arrested in a joint operation of Punjab and Haryana Police, on charges of harbouring fugitive Amritpal Singh and his uncle.
''CCTV footage showed that Waris Punjab De chief and his close aide Pappalpreet Singh took refuge at her under-construction shelter,'' he said.
The fugitive pro-Khalistan leader was last spotted in Haryana.
Also read: Punjab Police issues lookout circular, non-bailable warrant against pro-Khalistani leader Amritpal Singh
Copyright©2023 Living Media India Limited. For reprint rights: Syndications Today

domain: law


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Recording the worst quarterly investment return since April last year, the world’s largest pension fund was a net seller of equities in the second quarter.
Experts believe the Japanese pension fund’s decision will have limited impact on global investors’ appetite for China sovereign papers, and any impact would be felt more in Japan’s public sector.
Generally, however, Asian pension funds’ allocations to alternative assets demonstrated only a modest increase of 0.6% from 2019 to 2020.
The world’s largest pension fund greatly benefitted from its nearly 50% asset allocation to equities after the global stock rally since April last year.
The fund's move to repurpose its asset allocation and alter its management structure, as well as commit to improved governance, earns it an Institutional Excellence Award.
The world’s largest pension fund is embarking on significant structural changes that will give global asset managers something to think about, as a model for the wider industry to follow.


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Human Rights Watch voiced concern on Thursday that an airstrike by the Saudi-led coalition on a warehouse of the aid group Oxfam appears to have violated the laws of war.
The strike occurred on April 18 at Oxfam’s facility in the northern city of Sadaa, killing and injuring dozens of civilians.
Under the laws of war “civilians and civilian objects may never be deliberate targets of attack,” the New York-based watchdog said in a statement.
“The fact that the Oxfam warehouse should have been known to the coalition forces raises concerns that the attack was deliberate.”
Oxfam’s Yemen country director, Grace Ommer, called the warehouse attack “an absolute outrage.”
She said the British-based charity told the coalition where its offices and storage facilities were located.
“The contents of the warehouse had no military value,” but contained material related to the group’s provision of clean water to thousands of households in Sadaa, Ommer said in a statement.
According to the United Nations, millions of people have been affected by conflict in Yemen, where they are struggling to access healthcare, water, food and fuel.
“The dire humanitarian situation in Yemen is made worse by attacks on relief supplies,” Human Rights Watch said.
The Saudi-led coalition declared an end Tuesday to its aggression on Yemen, nearly a month after launching air strikes against the civilians in the impoverished Arab country on March 26.
According to reports, about 2,800 people have been killed during the aggression, and thousands others were injured.

domain: politics


The Twitter handle of Nigeria’s First lady, Aisha Buhari, has been deactivated. This comes hours after the Buhari-led government
The Twitter handle of Nigeria’s First lady, Aisha Buhari, has been deactivated. This comes hours after the Buhari-led government announced the suspension of the micro-blogging site’s operations in the country.
The issues of Twitter in Nigeria began after Twitter deleted a tweet by the Major General Muhammad Buhari, the tweet which threatens the lives of people at the East.
According to Twitter, this tweet violates their law as it poses threat to human lives, due to this, the Minister For information and Culture Lai Mohammed had a press conference where he tagged Twitter as double standard and called for their ban.
A search on Twitter for her handle shows it has been deactivated. See a screenshot below
Meanwhile President Buhari’s Twitter handle is still active.
Website Designing/Management/Social Media – Iyanu Victor


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- What makes bulging discs worse?
- What should I avoid with a bulging disc?
- How do you fix a bulging disc in your lower back?
- Is walking good for a bulging disc?
- What are the symptoms of a bulging disc in your lower back?
- How long does a bulging disc last?
- What is the fastest way to heal a bulging disc?
- Can you fix a bulging disc without surgery?
- Can a chiropractor fix a bulging disc?
- What is the best exercise for bulging disc?
- Is heat good for bulging disc in back?
- Does a bulging disc go away?
- How long does it take for a bulging disc to heal without surgery?
- What causes a bulging disc to flare up?
- What is the best pain medication for a bulging disc?
- How do you relieve bulging disc pain?
What makes bulging discs worse?
The pain from a herniated disc usually is worse when you are active and gets better when you are resting.
Coughing, sneezing, sitting, driving, and bending forward may make the pain worse.
The pain gets worse when you make these movements because there is more pressure on the nerve..
What should I avoid with a bulging disc?
THINGS TO AVOID WITH A BULGING DISCheat (and heat rubs) in the first 48-72 hours of injury.total bed rest (this has been shown to prolong the recovery)sitting in soft chairs that put pressure on the low back.any period of long standing or sitting.slouching or poor posture.
How do you fix a bulging disc in your lower back?
Nonsurgical TreatmentRest. One to 2 days of bed rest will usually help relieve back and leg pain. … Nonsteroidal anti-inflammatory medications (NSAIDs). Medications such as ibuprofen or naproxen can help relieve pain.Physical therapy. … Epidural steroid injection.
Is walking good for a bulging disc?
Your doctor may also prescribe dynamic lumbar stabilization exercises. This program features exercises that work the abdominal and back muscles to address posture, flexibility, and strength. Moderate aerobic activities, including walking, biking, and swimming, also help relieve pain.
What are the symptoms of a bulging disc in your lower back?
SymptomsArm or leg pain. If your herniated disk is in your lower back, you’ll typically feel the most pain in your buttocks, thigh and calf. … Numbness or tingling. People who have a herniated disk often have radiating numbness or tingling in the body part served by the affected nerves.Weakness.
How long does a bulging disc last?
If you’ve experienced symptoms for less than 6 weeks and have no nerve damage, anti-inflammatory medications, physical therapy, and steroid injections (if needed) can help resolve the issue in 6 to 12 weeks.
What is the fastest way to heal a bulging disc?
Here are 5 little-known tips to help relieve pain and get you on your way to feeling better:Heat and cold therapy can help relieve muscle tension and pain. … Moderate physical activity releases endorphins. … Certain sleep positions help relieve herniated disc pain. … The McKenzie Method can help shift sciatica pain.More items…•
Can you fix a bulging disc without surgery?
ANSWER: In many cases, pain and other symptoms caused by a herniated disk resolve with time and self-care measures. When medical treatment is required, therapy that doesn’t involve surgery often is all that’s needed to effectively treat herniated disk symptoms.
Can a chiropractor fix a bulging disc?
Chiropractic care is the preferred treatment method for many patients suffering from a bulging disc. It is non-invasive and does not require drugs or injections of any kind. Chiropractic can help provide you with improved mobility, decreased pain, and overall better quality of life.
What is the best exercise for bulging disc?
Exercise and Physical Therapy ( Osteopaths/Physiotherapy) are often the most important parts of recovery from a herniated disc….Gentle activities that can help are;Pilates.Yoga.Swimming.Walking.Cycling.
Is heat good for bulging disc in back?
For mild herniated disc pain, relieve the inflammation to decrease pain. For instance, applying a heating pad or ice pack to the affected area may be a good way to temporarily relieve your pain and reduce inflammation.
Does a bulging disc go away?
Usually a herniated disc will heal on its own over time. Be patient, and keep following your treatment plan. If your symptoms don’t get better in a few months, you may want to talk to your doctor about surgery.
How long does it take for a bulging disc to heal without surgery?
Most people recover from a slipped disc within six weeks without treatment. Until then there are a number of treatment options that aim to help relieve the pain and improve mobility.
What causes a bulging disc to flare up?
In addition to natural wear and tear, other factors that can contribute to a bulging disc include repetitive movements, strenuous lifting, twisting of the body, bone spurs pushing against the disc, and many other degenerative conditions.
What is the best pain medication for a bulging disc?
If your pain is mild to moderate, your doctor might recommend over-the-counter pain medication, such as acetaminophen (Tylenol, others) ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve).
How do you relieve bulging disc pain?
For mild herniated disc pain, relieve the inflammation to decrease pain. For instance, applying a heating pad or ice pack to the affected area may be a good way to temporarily relieve your pain and reduce inflammation. Take 10-15 minutes twice a day to lie on your stomach with one to two pillows under your hips.

domain: medical


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I got a nice new notebook on the weekend so I'm hoping that it will get me to start writing again. While I was still in high school I wrote this pretty long like Lord Of The Rings/Dungeons And Dragons type of story. I wrote it over a few years I think. And I really enjoyed writing it and coming up with different characters and everything. Then I started to write my own Star Wars type of story which I never even came close to finishing but I thought it was kind of a neat story idea. And now I want to start writing a new story but I'm not what the story should be.
See, for me I find it easier to come up with Sci-fi stories but to write real life like stories it's extremely hard for me. Especially to make them interesting. But I want to write some kind of lesbian romance story that deals with real life and set in the present. I'm not sure if I'm gonna be able to do it though. In my sci-fi stories it's always like an adventure first and then a romance happens during the adventure. So, now to write a story that is really a romance first and it's the main focus is difficult and I don't really know where to start and how to make it unique and fun. Ugh, I should be good at this but I majorly suck. Ah, but I think I'm gonna give it a try tonight.