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Genomes and Genes
Gene Symbol: PNPLA3
Description: patatin like phospholipase domain containing 3
Alias: ADPN, C22orf20, iPLA(2)epsilon, patatin-like phospholipase domain-containing protein 3, acylglycerol O-acyltransferase, adiponutrin, calcium-independent phospholipase A2-epsilon, iPLA2-epsilon, iPLA2epsilon
Publications151 found, 100 shown here
- PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic diseaseElizabeth K Speliotes
Department of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA
Hepatology 52:904-12. 2010..The G allele of rs738409 in PNPLA3 was associated with increased odds of histologic NAFLD (odds ratio [OR] = 3.26, 95% confidence intervals [CI] = 2...
- Variant in PNPLA3 is associated with alcoholic liver diseaseChao Tian
Perlegen Sciences, Mountain View, California, USA
Nat Genet 42:21-3. 2010Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels...
- Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymesXin Yuan
Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
Am J Hum Genet 83:520-8. 2008..two loci influencing plasma levels of alanine-aminotransferase (ALT) (CPN1-ERLIN1-CHUK on chromosome 10 and PNPLA3-SAMM50 on chromosome 22), one locus influencing gamma-glutamyl transferase (GGT) levels (HNF1A on chromosome 12), ..
- Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descentS Romeo
Institute of Metabolic Science, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 0QQ, UK
Int J Obes (Lond) 34:190-4. 2010The PNPLA3 I148M variant (rs738409) is robustly associated with hepatic steatosis...
- A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescentsNicola Santoro
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
Hepatology 52:1281-90. 2010..Recently, a nonsynonymous single-nucleotide polymorphism (rs738409), in the patatin-like phospholipase 3 gene (PNPLA3) has been associated with hepatic steatosis in adults...
- Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytesCéline Dubuquoy
INSERM, U1016, Institut Cochin, Paris, France
J Hepatol 55:145-53. 2011The adiponutrin/PNPLA3 (patatin-like phospholipase domain-containing protein 3) variant I148M has recently emerged as an important marker of human fatty liver disease...
- A common variant in the PNPLA3 gene is a risk factor for non-alcoholic fatty liver disease in obese Taiwanese childrenYu Cheng Lin
Department of Pediatrics, Far Eastern Memorial Hospital, Banqiao City, Taipei County, Taiwan
J Pediatr 158:740-4. 2011To test the hypothesis that the presence of the PNPLA3 rs738409 G allele would increase the susceptibility of non-alcoholic fatty liver disease (NAFLD) in obese Taiwanese children.
- PNPLA3 polymorphisms and liver aminotransferase levels in a Mexican American populationQuan Li
The University of Texas School of Public Health, Brownsville, TX 78520, USA
Clin Invest Med 35:E237-45. 2012This study examined genetic associations of patatin-like phospholipase domain containing 3 gene (PNPLA3) polymorphisms and liver aminotransferases in an extensively documented, randomly recruited Mexican American population at high risk ..
- Variation in the adiponutrin gene influences its expression and associates with obesityLovisa E Johansson
Department of Clinical Sciences Malmo, Clinical Obesity, Lund University, University Hospital MAS, S 205 02 Malmo, Sweden
Diabetes 55:826-33. 2006b>Adiponutrin is one of three recently identified adipocyte lipases. Surprisingly, these proteins also retain transacylase activity, a hitherto unknown pathway of triacylglycerol synthesis in the adipocytes...
- Adiponutrin: A new gene regulated by energy balance in human adipose tissueYong Ming Liu
Equipe d Accueil 3502 and Institut National de la Santé et de la Recherche Médicale INSERM Avenir and Department de Nutrition, Paris VI University, Paris, France
J Clin Endocrinol Metab 89:2684-9. 2004b>Adiponutrin is a newly identified nonsecreted adipocyte protein regulated by changes in energy balance in rodents. We documented the influence of energy balance modification on adiponutrin gene expression in humans...
- Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activitiesChristopher M Jenkins
Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 279:48968-75. 2004..consensus sequence motifs identified a novel subfamily of three putative iPLA2/lipase family members designated iPLA2epsilon, iPLA2zeta, and iPLA2eta (previously named adiponutrin, TTS-2...
- Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family membersAndrew C Lake
Biological Technologies, Wyeth Research, Cambridge, MA 02140, USA
J Lipid Res 46:2477-87. 2005b>Adiponutrin and a related protein, adipocyte triglyceride lipase (ATGL; also known as Desnutrin), were recently described as adipocyte-specific proteins with lipid hydrolase activity...
- Characterization of the human patatin-like phospholipase familyPaul A Wilson
Bioinformatics Discovery and Analysis, GlaxoSmithKline Research and Development, Stevenage, England SG1 2NY, UK
J Lipid Res 47:1940-9. 2006..Given the observed conservation of the patatin fold and lipase motif in all human PNPLAs, a single nomenclature to describe the PNPLA family is proposed...
- Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesityLovisa E Johansson
Department of Clinical Sciences Malmo, Malmö University Hospital MAS, Lund University, Malmo, Sweden
Eur J Endocrinol 159:577-83. 2008The insulin responsive adiponutrin or patatin-like phospholipase 3 (PNPLA3, previously ADPN) gene shows association with obesity and in vitro adipocyte lipolysis...
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver diseaseStefano Romeo
Donald W Reynolds Cardiovascular Clinical Research Center, Eugene McDermott Center for Human Growth and Development, Dallas, TX 75390, USA
Nat Genet 40:1461-5. 2008..An allele in PNPLA3 (rs738409[G], encoding I148M) was strongly associated with increased hepatic fat levels (P = 5...
- Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functionsPetra C Kienesberger
Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria
J Lipid Res 50:S63-8. 2009..This review aims to summarize current knowledge of PNPLA proteins and to document their emerging importance in lipid and energy homeostasis...
- A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humansA Kotronen
Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
Diabetologia 52:1056-60. 2009It has recently been suggested that the rs738409 G allele in PNPLA3, which encodes adiponutrin, is strongly associated with increased liver fat content in three different ethnic groups...
- Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factorsAnna Kotronen
Department of Medicine, Division of Diabetes, University of Helsinki, Helsinki, Finland
Gastroenterology 137:865-72. 2009..disease (NAFLD) and liver fat content based on routinely available clinical and laboratory data and to test whether knowledge of the recently discovered genetic variant in the PNPLA3 gene (rs738409) increases accuracy of the prediction.
- Tri-iodothyronine upregulates adiponutrin mRNA expression in rat and human adipocytesR M Calvo
Instituto de Investigaciones Biomédicas Madrid, CSIC, Arturo Duperier, 4, 28029 Madrid, Spain
Mol Cell Endocrinol 311:39-46. 2009b>Adiponutrin (PNPLA3) is expressed in adipose tissue. Although its precise function is unknown, some data suggest a dual role in lipid homeostasis...
- Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 geneKonstantinos Kantartzis
Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tubingen, Tubingen, Germany
Diabetes 58:2616-23. 2009..scan, the rs738409 C>G single nucleotide polymorphism (SNP) in the patatin-like phospholipase 3 gene (PNPLA3) was strongly associated with increased liver fat but not with insulin resistance estimated from fasting values...
- Genetic evidence for a role of adiponutrin in the metabolism of apolipoprotein B-containing lipoproteinsBarbara Kollerits
Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
Hum Mol Genet 18:4669-76. 2009b>Adiponutrin (PNPLA3) is a predominantly liver-expressed transmembrane protein with phospholipase activity that is regulated by fasting and feeding...
- A nonsynonymous gene variant in the adiponutrin gene is associated with nonalcoholic fatty liver disease severitySilvia Sookoian
Laboratory of Clinical and Molecular Hepatology, Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research, University of Buenos Aires CONICET, Ciudad Autonoma de Buenos Aires, Argentina
J Lipid Res 50:2111-6. 2009We explored the role of the adiponutrin (PNPLA3) nonsynonymous-rs738409 single nucleotide polymorphism (SNP) in genetic susceptibility to nonalcoholic fatty liver disease (NAFLD) and whether this SNP contributes to the severity of ..
- A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysisShaoqing He
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Biol Chem 285:6706-15. 2010..Previously, we showed that a missense mutation (I148M) in PNPLA3 (patatin-like phospholipase domain-containing 3 protein) is associated with increased hepatic triglyceride content ..
- Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver diseaseLuca Valenti
Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Fondazione Ospedale Policlinico MaRE Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
Hepatology 51:1209-17. 2010..predisposition to nonalcoholic fatty liver disease (NAFLD), and the rs738409 C-->G polymorphism of PNPLA3/adiponutrin, encoding for the isoleucine-to-methionine substitution at residue 148 (I148M) protein variant, has recently ..
- The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in lifeStefano Romeo
Endocrinology and Diabetes, Department of Medical Sciences, University of Cagliari, Cagliari, Italy
J Hepatol 53:335-8. 2010..Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity in children. Recently, the PNPLA3 gene I148M (rs738409) variant was demonstrated to be strongly associated with hepatic steatosis in obese adults...
- On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health StudyGuillaume Pare
Department of Pathology and Molecular Medicine, Population Genomics Program, McMaster University, Hamilton, Canada
PLoS Genet 6:e1000981. 2010..levels, between the ICAM1 SNP rs1799969 and smoking in the prediction of soluble ICAM-1 levels, and between the PNPLA3 SNP rs738409 and body mass index in the prediction of soluble ICAM-1 levels...
- I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver diseaseLuca Valenti
Department of Internal Medicine, Universita degli Studi, Ospedale Maggiore Policlinico Ca Granda Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy
Hepatology 52:1274-80. 2010..Recently, the rs738409 C>G adiponutrin/patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism, which encodes the I148M protein variant ..
- The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver diseaseYaron Rotman
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1800, USA
Hepatology 52:894-903. 2010..C/G, a nonsynonymous coding SNP in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) (adiponutrin) gene encoding an Ile148Met change, was associated with steatosis (P = 0.03), portal inflammation (P = 2...
- Specifically PNPLA3-mediated accumulation of liver fat in obese patients with type 2 diabetesJean Michel Petit
Universite de Bourgogne, Centre de Recherche Institute National de la Santé, Dijon Cedex, France
J Clin Endocrinol Metab 95:E430-6. 2010Recently, it has been shown in the general population that an allele in the adiponutrin (PNPLA3) gene was strongly associated with increased liver fat content (LFC), independently of visceral adiposity and insulin resistance.
- Effects of PNPLA3 on liver fat and metabolic profile in Hispanic children and adolescentsMichael I Goran
Department of Preventive Medicine, Childhood Obesity Research Center, University of Southern California, Los Angeles, California, USA
Diabetes 59:3127-30. 2010A genome-wide study of adults identified a variant of PNPLA3 (rs738409) associated with ∼twofold higher liver fat...
- Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumptionJaimie N Davis
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Am J Clin Nutr 92:1522-7. 2010Recently, a genetic variant (rs738409; C→G) of the PNPLA3 gene was identified to be associated with increased hepatic fat deposition, and the effect was more pronounced in Hispanics...
- Regulation of the promoter region of the human adiponutrin/PNPLA3 gene by glucose and insulinSharleen M Rae-Whitcombe
Department of Biochemistry, University of Otago, Dunedin, New Zealand
Biochem Biophys Res Commun 402:767-72. 2010The adiponutrin/PNPLA3 gene is highly expressed in adipose tissue and liver. Its expression is down-regulated by fasting and rapidly induced by refeeding a high carbohydrate diet...
- Variant adiponutrin (PNPLA3) represents a common fibrosis risk gene: non-invasive elastography-based study in chronic liver diseaseMarcin Krawczyk
Department of Medicine II, Saarland University Hospital, Homburg, Germany
J Hepatol 55:299-306. 2011Recent genome-wide association studies have identified the variant p.I148M of the adiponutrin gene PNPLA3 as a risk factor for developing severe forms of non-alcoholic and alcoholic liver diseases...
- Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver diseaseKikuko Hotta
EBM Research Center, Kyoto University Graduate School of Medicine, Japan
BMC Med Genet 11:172. 2010..association scan, the single-nucleotide polymorphism (SNP) rs738409 in the patatin-like phospholipase 3 gene (PNPLA3) was strongly associated with increased liver fat content...
- Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosisTao Cai
Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Switzerland
J Hepatol 55:529-35. 2011..steatosis in chronic hepatitis C has been limited by the studies' small sample size, and important single nucleotide polymorphisms (SNPs), such as those in the patatin-like phospholipase family 3 protein (PNPLA3), were never evaluated.
- Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasiansFelix Stickel
Institute of Clinical Pharmacology and Visceral Research, University of Bern, Bern, Switzerland
Hepatology 53:86-95. 2011A recent genome-wide study revealed an association between variation in the PNPLA3 gene and liver fat content...
- Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family StudyLynne E Wagenknecht
Division of Public Health Sciences, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
Liver Int 31:412-6. 2011Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition, particularly among Hispanic Americans. A genetic variant in PNPLA3 (rs738409) has been identified as a strong predictor of hepatic fat content.
- Patatin-like phospholipase domain-containing 3 I148M polymorphism, steatosis, and liver damage in chronic hepatitis CLuca Valenti
Department of Internal Medicine, Universita degli Studi, Fondazione IRCCS Ospedale Maggiore Policlinico Ca Granda IRCCS, Milan, Italy
Hepatology 53:791-9. 2011..The rs738409 C>G patatin-like phospholipase domain-containing 3 (PNPLA3) single nucleotide polymorphism (SNP), encoding for the I148M protein variant, influences liver fat without ..
- Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver diseaseEric Trépo
Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
J Hepatol 55:906-12. 2011A recent genome-wide association study identified genetic polymorphism (rs738409 C>G) in the PNPLA3/adiponutrin gene associated with liver steatosis...
- Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver diseaseSilvia Sookoian
Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari IDIM, University of Buenos Aires National Council of Scientific and Technological Research CONICET, Ciudad Autonoma de Buenos Aires, Argentina
Hepatology 53:1883-94. 2011..to estimate the strength of the effect of the I148M (rs738409 C/G) patatin-like phospholipase domain containing 3 (PNPLA3) variant on nonalcoholic fatty liver (NAFLD) and disease severity across different populations...
- Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traitsElizabeth K Speliotes
Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS Genet 7:e1001324. 2011..liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis ..
- Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis CEric Trépo
Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, Erasme Hospital, Brussels, Belgium
Hepatology 54:60-9. 2011..A recent genome-wide association study identified a genetic variant in the patatin-like phospholipase-3 (PNPLA3) gene (rs738409 C>G) associated with steatosis that was further demonstrated to influence severity of fibrosis ..
- Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humansKsenia Sevastianova
Minerva Foundation Institute for Medical Research, Helsinki, Finland
Am J Clin Nutr 94:104-11. 2011The rs738409 C→G single nucleotide polymorphism in the patatin-like phospholipase domain-containing 3 (PNPLA3; adiponutrin) leads to a missense mutation (I148M), which is associated with increased liver fat but not insulin resistance...
- Association of PNPLA3 SNP rs738409 with liver density in African Americans with type 2 diabetes mellitusA J Cox
Center for Human Genomics, Wake Forest School of Medicine, Winston Salem, NC, USA
Diabetes Metab 37:452-5. 2011..2 diabetes mellitus (T2DM), and has been associated with the single nucleotide polymorphism (SNP) rs738409 in the PNPLA3 gene...
- The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic populationChih Wen Wang
Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan
Liver Int 31:1326-31. 2011The adiponutrin/patatin-like phospholipase-3 (PNPLA3) I148M polymorphism has recently been found to contribute to differences in hepatic lipid content...
- PNPLA3 rs738409C/G polymorphism in cirrhosis: relationship with the aetiology of liver disease and hepatocellular carcinoma occurrenceEdmondo Falleti
Department of Medical Sciences Experimental and Clinical, University of Udine, Udine, Italy
Liver Int 31:1137-43. 2011The PNPLA3 rs738409 C>G polymorphism has been found to be strongly associated with non-alcoholic fatty liver disease and with alcoholic liver disease...
- PNPLA3 polymorphism influences liver fibrosis in unselected patients with type 2 diabetesJean M Petit
Centre de Recherche, INSERM Unité 866, Universite de Bourgogne, CHU du Bocage, Dijon, France
Liver Int 31:1332-6. 2011Recently, it has been shown that an allele in the adiponutrin (PNPLA3) gene was strongly associated with increased liver fat content (LFC) and liver fibrosis independent of visceral adiposity and insulin resistance.
- The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liverLuca Valenti
Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Ospedale Maggiore Ca Granda Fondazione Policlinico IRCCS, Milan, Italy
J Hepatol 55:1409-14. 2011..The aim was to assess the association between APOC3 SNPs and liver damage in Caucasian patients...
- The common adiponutrin variant p.I148M does not confer gallstone risk but affects fasting glucose and triglyceride levelsM Krawczyk
Department of Medicine II, Saarland University Hospital, Saarland University, Homburg, Germany
J Physiol Pharmacol 62:369-75. 2011Recently the common adiponutrin (PNPLA3) polymorphism p.I148M has been identified as a genetic determinant of severe forms of non-alcoholic fatty liver disease and alcoholic liver disease...
- The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosisHans Dieter Nischalke
Department of Internal Medicine I, University of Bonn, Bonn, Germany
PLoS ONE 6:e27087. 2011An isoleucine>methionine mutation at position 148 in the PNPLA3 gene (p.I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in steatohepatitis...
- Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescentsNicola Santoro
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
Hepatology 55:781-9. 2012..Moreover, because recently rs738409 in the PNPLA3 and rs2854116 in the APOC3 were associated with fatty liver, we explored how the GCKR SNP and these two variants ..
- The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fatEmanuele Miraglia del Giudice
Department of Pediatrics, Seconda Universita degli Studi di Napoli, Napoli, Italy
PLoS ONE 6:e27933. 2011A polymorphism in adiponutrin/patatin-like phospholipase-3 gene (PNPLA3), rs738409 C->G, encoding for the I148M variant, is the strongest genetic determinant of liver fat and ALT levels in adulthood and childhood obesity...
- Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver diseaseJenni Hyysalo
Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Finland
J Gastroenterol Hepatol 27:951-6. 2012..Our aim was to determine the contribution of genetic variation in APOC3 on liver fat content and plasma triglyceride and apoC3 concentrations in a larger European cohort...
- A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver diseaseShamsul Mohd Zain
The Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
Hum Genet 131:1145-52. 2012The adiponutrin (PNPLA3) rs738409 polymorphism has been found to be associated with susceptibility to non-alcoholic fatty liver disease (NAFLD) in various cohorts...
- IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver diseaseSalvatore Petta
Sezione di Gastroenterologia, DiBiMIS, University of Palermo, Italy
J Hepatol 56:1356-62. 2012..The main outcomes of the study were to assess whether IL28B rs12979860 and rs8099917 polymorphisms, together with PNPLA3 rs738409 C>G polymorphism, are associated with lobular inflammation and fibrosis, in NAFLD patients.
- PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individualsMaria Antonella Burza
Department of Molecular and Clinical Medicine and Center for Cardiovascular and Metabolic Research, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Dig Liver Dis 44:1037-41. 2012..Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) genetic variant has been associated with hepatocellular carcinoma (HCC) in individuals with ..
- Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosisLuca Valenti
Universita degli Studi di Milano, Fondazione Cà Granda IRCCS Ospedale Maggiore Policlinico, 20122 Milano, Italy
World J Gastroenterol 18:2813-20. 2012To investigate whether the patatin-like phospholipase domain containing-3 gene (PNPLA3) I148M polymorphism is associated with steatosis, fibrosis stage, and cirrhosis in hereditary hemochromatosis (HH).
- Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in JapaneseTakahisa Kawaguchi
Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
PLoS ONE 7:e38322. 2012....
- Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variantColin N A Palmer
Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, United Kingdom
PLoS ONE 7:e39362. 2012..The I148M (rs738409) genetic variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is known to modulate hepatic triglyceride accumulation, leading to steatosis...
- Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitroCarlo Pirazzi
Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden
J Hepatol 57:1276-82. 2012..The robust association between non-alcoholic fatty liver disease (NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely replicated...
- The I148M PNPLA3 polymorphism influences serum adiponectin in patients with fatty liver and healthy controlsLuca Valenti
Department of Internal Medicine, Università degli Studi Milano, UO Medicina Interna 1B, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
BMC Gastroenterol 12:111. 2012..liver disease (NAFLD) and steatohepatitis (NASH), and the I148M Patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism predisposes to NAFLD and liver damage progression in NASH and chronic hepatitis C (CHC) by still ..
- Genetic variant I148M in PNPLA3 is associated with the ultrasonography-determined steatosis degree in a Chinese populationYiling Li
Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, China
BMC Med Genet 13:113. 2012..single nucleotide polymorphism rs738409 (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) predisposes susceptibility to NAFLD; however, its association with steatosis grade is inconsistent in the ..
- PNPLA3 I148M variant and hepatocellular carcinoma: a common genetic variant for a rare diseaseLuca Valenti
Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Section of Internal Medicine, Italy
Dig Liver Dis 45:619-24. 2013..The rs738409 genetic variant in the patatin-like phospholipase domain-containing 3 (PNPLA3, adiponutrin) gene has been implicated as a genetic determinant of the entire spectrum of liver diseases, ranging from ..
- A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese populationA Verrijken
Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, University of Antwerp, Belgium
Obesity (Silver Spring) 21:2138-45. 2013..We studied the association between the genes patatin-like phospholipase domain-containing protein 3 (PNPLA3) and apolipoprotein C3 (APOC3) and metabolic and histological parameters of NAFLD in obese patients.
- Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in JapanTakuya Kitamoto
EBM Research Center, Kyoto University Graduate School of Medicine, Yoshida Konoecho, Sakyo ku, Kyoto 606 8501, Japan
Hum Genet 132:783-92. 2013..Rs738409 in the PNPLA3 gene was most strongly associated with NAFLD after adjustment (P = 6.8 × 10(-14), OR = 2.05)...
- Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesityJenni Hyysalo
Department of Medicine, University of Helsinki, Helsinki, Finland
Diabetes 63:312-22. 2014..relative concentrations of circulating triacylglycerols (TAGs) between carriers compared with noncarriers of PNPLA3(I148M) gene variant display deficiency of TAGs, which accumulate in the liver because of defective lipase activity...
- PNPLA3-associated steatohepatitis: toward a gene-based classification of fatty liver diseaseMarcin Krawczyk
Department of Medicine II, Saarland University Medical Center, Homburg, Germany
Semin Liver Dis 33:369-79. 2013..Recently, the common variant p.I148M of the enzyme adiponutrin (PNPLA3) has emerged as a major genetic determinant of hepatic steatosis and nonalcoholic steatohepatitis as ..
- PNPLA3 I148M polymorphism and progressive liver diseasePaola Dongiovanni
Paola Dongiovanni, Benedetta Donati, Roberta Fares, Rosa Lombardi, Luca Valenti, Internal Medicine, Fondazione IRCCS Ca Granda Ospedale Policlinico Milano, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, 20122 Milano, Italy
World J Gastroenterol 19:6969-78. 2013The 148 Isoleucine to Methionine protein variant (I148M) of patatin-like phospholipase domain-containing 3 (PNPLA3), a protein is expressed in the liver and is involved in lipid metabolism, has recently been identified as a major ..
- Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of functionPiero Pingitore
Department BEST Biologia, Ecologia, Scienze della Terra, Unit of Biochemistry and Molecular Biotechnology, University of Calabria, Via P Bucci 4c, 87036 Arcavacata di Rende, Italy Department of Chemistry and Molecular Biology, University of Gothenburg, PO Box 462, SE 405 30 Goteborg, Sweden
Biochim Biophys Acta 1841:574-80. 2014The patatin-like phospholipase domain containing 3 (PNPLA3, also called adiponutrin, ADPN) is a membrane-bound protein highly expressed in the liver...
- Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individualsYu Cheng Lin
Department of Pediatrics, Far Eastern Memorial Hospital, Taipei, Taiwan Y CL and P FC the Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan M HC and Y HN and the Oriental Institute of Technology, New Taipei City, Taiwan Y CL
Am J Clin Nutr 99:869-74. 2014A genome-wide association study identified variants in or near patatin-like phospholipase domain-containing-3 (PNPLA3), neurocan (NCAN), lysophospholipase-like 1 (LYPLAL1), glucokinase regulatory protein (GCKR), and protein phosphatase 1 ..
- Role of the PNPLA3 I148M polymorphism in nonalcoholic fatty liver disease and fibrosis in KoreaSang Soo Lee
Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82 Gumi ro, 173 Beon gil, Bundang gu, Seongnam si, 463 707, Gyeonggi Do, Republic of Korea
Dig Dis Sci 59:2967-74. 2014The role of the patatin-like phospholipase domain-containing 3 (PNPLA3) single-nucleotide polymorphism (SNP), rs738409, in the development and progression of nonalcoholic fatty liver disease (NAFLD) has not been studied in the Korean ..
- Effects of rosiglitazone and high fat diet on lipase/esterase expression in adipose tissueWen Jun Shen
Division of Endocrinology, Stanford University and VA Palo Alto Health Care System, Palo Alto, CA 94304, USA
Biochim Biophys Acta 1771:177-84. 2007..We found that the relative mRNA levels of ATGL and HSL are the most abundant, being 2-3 fold greater than TGH or ADPN; whereas other intracellular neutral lipase/esterases were expressed at substantially lower levels...
- Adipokine gene expression in brain and pituitary glandMichael Wilkinson
Department of Obstetrics and Gynaecology, Dalhousie University, Halifax, N S, Canada
Neuroendocrinology 86:191-209. 2007..others, confirmed that the genes for leptin, resistin, adiponectin, FIAF (fasting-induced adipose factor) and adiponutrin are expressed and regulated in these tissues...
- [Analysis of metabolic syndrome and pulse wave velocity in hemodialysis patients: diagnosis of obesity by bioelectrical impedance analysis and a novel risk factor for atherosclerosis]Nobuhiro Sasaki
Kawashima Medical Clinic, Ibaraki, Japan
Nihon Jinzo Gakkai Shi 51:476-83. 2009..Therefore, we evaluated atherosclerosis and Met S in HD patients using various markers of obesity by means of bioelectrical impedance analysis (BIA) and brachial-ankle PWV(baPWV)...
- Insulin regulation of gene expression and concentrations of white adipose tissue-derived proteins in vivo in healthy men: relation to adiponutrinMay Faraj
Laboratoire des dysfonctions Métabolique, Departement de Nutrition, Faculte de Medicine, Universite de Montreal, 2405 Chemin Cote Ste Catherine, Montreal, Quebec, Canada H3T 1A8
J Endocrinol 191:427-35. 2006b>Adiponutrin is a newly described white adipose tissue (WAT)-derived protein whose function and regulation remain widely unclear in humans though it is suggested to be related to insulin sensitivity...
- High serum adiponectin levels during steroid-responsive nephrotic syndrome relapseSevcan A Bakkaloglu
Department of Pediatric Nephrology, Gazi University, Besevler, 06540 Ankara, Turkey
Pediatr Nephrol 20:474-7. 2005Adiponectin (ADPN), exclusively expressed and secreted from adipocytes, is a recently discovered protein hormone with anti-atherogenic and anti-inflammatory properties in contrast to other well-known adipocytokines...
- Hyperleptinaemia and chronic inflammation after peritonitis predicts poor nutritional status and mortality in patients on peritoneal dialysisMan Fai Lam
Department of Medicine, University of Hong Kong, Queen Mary Hospital, NO 102, Pokfulam Road, Hong Kong
Nephrol Dial Transplant 22:1445-50. 2007..The nutritional status of PD patients may further be worsened following peritonitis. We investigated the association between hyperleptinaemia, inflammation and malnourishment in PD-related peritonitis...
- Accessory deep peroneal nerve - a clinically significant anomaly?Szymon Owsiak
Department of Neurology, Medical University of Warsaw, Warsaw, Poland
Neurol Neurochir Pol 42:112-5. 2008The accessory deep peroneal nerve (ADPN), a variant of the peroneal nerve, may give motor branches to the extensor digitorum brevis muscle (EDB) in 19-28% of the general population and in up to 78% of subjects in familial cases...
- The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid statusMenno Hoekstra
Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
J Hepatol 52:244-51. 2010Recent studies have suggested that variations in PNPLA3 are associated with non-alcoholic fatty liver disease (NAFLD)...
- Adiponectin levels and atherosclerotic risk factors in pediatric chronic peritoneal dialysis patientsSevcan A Bakkaloglu
Department of Pediatric Nephrology, Gazi University, Ankara, Turkey
Perit Dial Int 25:357-61. 2005..Adiponectin (ADPN) is a recently discovered adipocyte-derived plasma protein having anti-atherogenic properties...
- Resistin differentially modulates neuropeptide gene expression and AMP-activated protein kinase activity in N-1 hypothalamic neuronsRussell E Brown
Department of Obstetrics and Gynaecology, Dalhousie University, IWK Health Centre, 5850 5980 University Avenue, PO Box 9700, Halifax, Nova Scotia B3K 6R8, Canada
Brain Res 1294:52-60. 2009..and the N-1 hypothalamic neuronal cell line, also expressed several adipokines, including resistin and adiponectin (ADPN). These data suggested that they might also impact brain function and metabolism...
- Effects of long-term ethanol administration in a rat total enteral nutrition model of alcoholic liver diseaseMartin J J Ronis
epartment of Pharmacology and Toxicology, 2University of Arkansas for Medical Sciences and Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
Am J Physiol Gastrointest Liver Physiol 300:G109-19. 2011..5 ± 0.6 vs. 2.7 ± 1.2), associated with suppression of the triglyceride hydrolyzing protein adiponutrin, but produced no elevation in serum alanine aminotransferase (ALT)...
- Oleoyl-estrone treatment to late pregnant and mid-lactating rats affects the expression of lipid metabolism genesBeatriz García-Peláez
Departament de Nutrició i Bromatologia, Facultat de Biologia, Universitat de Barcelona, Av Diagonal, 645, 08028, Barcelona, Spain
Lipids 42:827-33. 2007..The expression of LPL, FATP1, FABP4, HSL, ACC1, FAS, PEPCK, GLUT4, PDK4, SREBP1c, adiponutrin and leptin, were compared with their expression in virgin rats...
- Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal diseaseCarmine Zoccali
National Research Council Center of Clinical Physiology, Reggio Calabria, Italy
J Am Soc Nephrol 13:134-41. 2002Adiponectin (ADPN), which is a secretory protein of adipose tissue, attenuates endothelial inflammatory responses in vitro...
- Increased serum adiponectin levels in type 1 diabetic patients with microvascular complicationsJ Frystyk
Medical Research Laboratories, Clinical Institute and Medical Department M Diabetes and Endocrinology, Aarhus University Hospital, Aarhus C, Denmark
Diabetologia 48:1911-8. 2005Low serum adiponectin (ADPN) has been associated with increased risk of cardiovascular disease (CVD) and retinopathy in patients with type 2 diabetes mellitus...
- Adiponectin levels and arteriosclerotic risk factors in pediatric renal transplant recipientsSevcan A Bakkaloglu
Department of Pediatric Nephrology, Gazi University, Ankara, Turkey
Pediatr Transplant 10:187-92. 2006b>ADPN, a recently discovered adipocytokine, has attracted great attention because of its anti-atherogenic properties...
- Heritability of plasma adiponectin levels and body mass index in twinsMaurizio Cesari
Department of Clinical and Experimental Medicine, Clinica Medica 4 University Hospital, University of Padova, Italy
J Clin Endocrinol Metab 92:3082-8. 2007..Adiponectin is suspected to exert antiatherogenic, antiinflammatory, and insulin-sensitizing effects. However, the relative importance of the genetic and environmental factors in influencing plasma adiponectin levels (ADPN) remains unclear.
- Plasma adiponectin levels and clinical outcomes among haemodialysis patientsMadhumathi Rao
Division of Nephrology, Department of Medicine, Tufts New England Medical Center Hospitals, Box 391, 750 Washington Street, Boston, MA 02111, USA
Nephrol Dial Transplant 23:2619-28. 2008Adiponectin (ADPN) levels are consistently elevated among patients with advanced chronic kidney disease, but its relationship with cardiovascular outcomes in this population remains controversial.
- Paradoxical role for adiponectin in chronic renal diseases? An example of reverse epidemiologyJoachim Beige
Hospital St Georg, Divison of Nephrology, 2nd Department of Internal Medicine, Klinikum St Georg, Delitzscher Street 141, 04129 Leipzig, Germany
Expert Opin Ther Targets 13:163-73. 2009Adiponectin (ADPN) is an adipocyte-derived protein with potential antiatherogenic properties...
- Plasma adiponectin levels in chronic kidney disease patients: relation with molecular inflammatory profile and metabolic statusG D Norata
Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133 Milan, Italy
Nutr Metab Cardiovasc Dis 20:56-63. 2010Adiponectin (ADPN) exerts anti-inflammatory and cardio protective effects and is associated with decreased cardiovascular risk, however its role in patients with chronic kidney disease is unclear.
- A feed-forward loop amplifies nutritional regulation of PNPLA3Yongcheng Huang
Departments of Molecular Genetics and Internal Medicine, The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 107:7892-7. 2010..Previously, we identified a sequence variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) that confers susceptibility to both hepatic triglyceride (TG) deposition and liver injury...
- Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver diseaseWeiqin Chen
Diabetes and Endocrinology Research Center, Section of Diabetes and Endocrinology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Hepatology 52:1134-42. 2010PNPLA3 (adiponutrin), a novel patatin-like phospholipase domain-containing enzyme, is expressed at high level in fat, but also in other tissues including liver. Polymorphisms in PNPLA3 have been linked to obesity and insulin sensitivity...
- Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineageS Baulande
Universite Pierre et Marie Curie, UMR Physiologie et Physiopathologie, CNRS, 15 rue de l Ecole de Medecine, 75270 Paris, Cedex 06, France
J Biol Chem 276:33336-44. 2001..Based on its adipose specificity and dietary regulation, the novel gene product has been designated adiponutrin. The expression of adiponutrin mRNA is also 50-fold elevated in genetically obese fa/fa rats, indicating a link ..
- Association between plasma adiponectin concentration and visceral fat accumulation in hemodialysis patientsMari Odamaki
Department of Clinical Nutrition, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan
Nephron Clin Pract 102:c8-13. 2006..Adiponectin (ADPN) is a recently discovered adipocyte-derived protein that appears to have protective role against atherosclerosis...
- Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrinErin E Kershaw
Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Diabetes 55:148-57. 2006..ATGL shares the greatest sequence homology with adiponutrin, a nutritionally regulated protein of unclear biological function...
- Association of high-molecular-weight to total adiponectin ratio with pulse wave velocity in hemodialysis patientsAkihiko Kato
Division of Blood Purification, Hamamatsu University School of Medicine, Hamamatsu, Japan
Nephron Clin Pract 109:c18-24. 2008High-molecular-weight adiponectin (HMW ADPN) plays an important role in the regulation of insulin action and atherogenic processes, but the role of HMW ADPN remains to be determined in hemodialysis (HD) patients...
- Serum adiponectin acutely after an ischemic stroke: implications for a long-lasting, suppressed anti-inflammatory roleS Marousi
Department of Neurology, University Hospital of Patras, Greece
Acta Neurol Scand 121:277-84. 2010Past ischemic stroke (IS) patients display suppressed adiponectin (ADPN) levels a few months after disease onset...
- Differences in mRNA expression of adipocyte-derived factors in response to fasting, refeeding and leptinFabrice Bertile
Centre d Ecologie et Physiologie Energetiques, UPR 9010 CNRS, Associé à l Université Louis Pasteur, 23 rue Becquerel, 67087 Strasbourg Cedex 2, France
Biochim Biophys Acta 1683:101-9. 2004..Leptin, adiponectin, resistin, adiponutrin, and insulin-like growth factor-1 (IGF-1) gene expressions differentially decreased according to the fasting ..
- Inflammatory proteins as predictors of cardiovascular disease in patients with end-stage renal diseaseCarmine Zoccali
CNR IBIM, Epidemiologia Clinica e Fisiopatologia delle Malattie Renali e dell Ipertensione Arteriosa, Unita Operativa di Nefrologia, Dialisi e Trapianto Renale, Ospedali Riuniti VI piano, 89125 Reggio Calabria, Italy
Nephrol Dial Transplant 19:V67-72. 2004..interleukin-6, tumour necrosis factor-alpha, as well as adipocyte-specific proteins, leptin and adiponectin (ADPN)...
- Asymmetric dimethylarginine in obesity after renal transplantationVladimir Teplan
Department of Nephrology, Transplant Center, Institute for Clinical and Experimental Medicine and Postgraduate Medical School, Prague, Czech Republic
J Ren Nutr 18:513-20. 2008..We have assessed in obese renal transplant recipients a course of selected proinflammatory factors liable to influence the long-term outcome of transplant patients and kidney grafts...
- [Cloning of human adiponectin gene by PCR-driven overlap extension and expression in Pichia pastoris]Bianling Zhang
Key Laboratory of Resource Biology and Biotechnology in Western China, School of Life Science, Northwest University, Xi an 710069, China
Sheng Wu Gong Cheng Xue Bao 24:1480-4. 2008Gene of human adiponectin (ADPN) was cloned by PCR-driven overlap extension. The ADPN gene was linked into pGEM-T vector. After the sequence was determined, the ADPN gene was subcloned into expression vector pPIC3...
- HELEN HASKELL HOBBS; Fiscal Year: 2016..Recently, we identified a missense mutation (I148M) in patatin-like phospholipase domain-containing protein, PNPLA3 that is strongly associated with both hepatic TG content and hepatic injury...
- MATTHEW ALVIN MITSCHE; Fiscal Year: 2016..Patatin-like phospholipase domain containing 3 (PNPLA3) was first implicated in the metabolism of hepatic triacylglycerides (TAGs) when our lab found that a missense ..
- John B Whitfield; Fiscal Year: 2015..To date, only one genetic polymorphism (in PNPLA3) has shown replicable positive result as a risk factor for ALC, although evidence from twin studies and Inter-..
- Autologus adipose tissue grafts to inhibit hemodialysis access stenosisCHRISTI MARIE TERRY; Fiscal Year: 2012..Adipocytes release many peptides, including adiponectin (ADPN) which has beneficial vascular effects, such as decreasing the expression of cellular adhesion molecules and ..
- GENCAC - North Carolina Field CenterLynne Wagenknecht; Fiscal Year: 2004..This application corresponds to the GENCAC clinic submitted by the Wake Forest University School of Medicine as part of the GENCAC genetic epidemiology network. ..
- ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIETMartin Ronis; Fiscal Year: 2005....
- ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCYMartin Ronis; Fiscal Year: 2006..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
- Analysis of Fatty Liver in the Framingham Heart Study CohortELIZABETH SPELIOTES; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Mitochondiral Injury and Anemia in Elderly Patients with Chronic Kidney DiseaseMadhumathi Rao; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Contribution of ATGL in skeletal muscle to lipid metabolism and insulin actionERIN KERSHAW; Fiscal Year: 2008..Evaluating the role of ATGL-mediated fat breakdown in skeletal muscle will provide important insights into the pathophysiology and treatment of obesity, insulin resistance, and related metabolic disorders. [unreadable] [unreadable]..
- INTRA-ABDOMINAL FAT AND RISK OF DISEASE IN ADOLESCENTSMichael Goran; Fiscal Year: 2008....
- GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASISLynne Wagenknecht; Fiscal Year: 2009..abstract_text> ..
- TGF-beta1 and PAI-1 genotypes in Chronic Kidney DiseaseMadhumathi Rao; Fiscal Year: 2008..The proposed training program and research project will prepare her for a career as an independent investigator. ..

domain: medical


text:
There are many resources available to couples going through a divorce, whether it’s amicable or contentious. But maybe your primary concern in the divorce isn’t how to deal with your spouse during the process. Instead, if you’re facing a high net worth divorce and your top priority is securing your financial future, here […]
Women who take their children and flee domestic abuse in another jurisdiction to return to Minnesota may face another set of (legal) problems once they arrive. Here’s how to best navigate them. October 2019 is the 30th annual National Domestic Violence Awareness Month. In recognizing the occasion, I am grateful for the opportunity to share […]
Personal Statement by Amanda Alvarado Social change starts with one person who has passion and motivation to change the community around them for the better. My motivation comes from my past, I have been homeless, have had family members incarcerated, experiencing sexism and racism, and have had friends and family members survive sexual assault. The […]
Whether we like it or not, social media has been integrated into nearly every aspect of our lives. We post so many details of our daily activities on our personal pages: weddings, births, vacations, and every moment in between. These posts can show us a lot about the way someone is spending their time, which […]
Since I’ve launched my Friendly Divorce services, I’ve had many couples interested in the benefits of Friendly Divorce and how they can make it work for them.

domain: sociology


text:
I’m excited to share with you some of my underrated and hidden gem food trucks in the city. You can usually find these on Facebook or Instagram to see where they’ll be on what day. Insider tip: Use StreetFoodFinder to find new food trucks to try in the city! Food trucks are a great medium for those who have a specific passion for food. It allows foodies to try an idea at a minimal hit to the expenses. Check out these food trucks and tag us in your pictures when you grab your plate!
A great fusion of Mexican and Asian cuisine, Jose’s Kitchen is a great stop! If you can’t find their food truck, definitely go to their restaurant in Smyrna. I love their fish tacos and honey sake chicken with fried rice.
405 Old Nashville Hwy | La Vernge, TN 37086
Imagine your classic favorites all at one spot! GrillWorx Food Truck has great tenders, sauces, and burgers! Enjoy a great set of chicken tenders and fries that will keep you coming back.
1137 Woodvale Dr. | Gallitan, TN 37066
If you know me, you know I love a great carb source! This is authentic Italian in a food truck. Enjoy their pasta which you can purchase to make at home and their tiramisu!
View their food truck calendar here to see their location for the day
Rollin Recipe is known for its amazing mac & cheese. They have a great ability to answer your customization requests paired with mac & cheese! I definitely recommend the NOLA Shrimp and Mac & Cheese.
View their social media for the food truck location calendar
To get more guides and stories of the people behind the culture and soul of Nashville, subscribe to our weekly newsletter HERE.

domain: hobby


text:
Tuesday, March 06, 2007
I spent all of last week in London promoting my book, which has the new title in the UK of Birth: A History. After 10 BBC interviews it was clear that many issues around birth are universal: Women grappling with pain relief, political fights surrounding who controls birth, and economic issues that ultimately decide where, when, how and with whom women deliver. But there are some differences between birth in America and birth in the UK. First, their maternal and neonatal mortality rates are better than ours. Their midwifery rates are higher than ours, and their health czar recently came out publicly to promote home birth, saying she recognized that decades of studies have consistently found home birth to be at least as safe as hospital births for low-risk women. And it's cheaper for the National Health Service, their universal health care system. The trouble is, there aren't enough midwives to facilitate home birth. But women have already picked up on the government's pitch. They like the idea. They're going into labor with the plan of staying at home. Sometimes a midwife gets there in time. Sometimes she doesn't.


text:
Selling our 2015 Scamp 13 FT Travel Trailer.
This trailer is ideal for traveling without the inconvenience of setup.
One of the biggest advantages of this trailer is how compact and lightweight they are,
which allows them to be towed by a wide variety of vehicles, it only weighs around 1500 pounds.
These trailers are known for their longevity and unique design. which is why you rarely see them
The front of the layout floor plan contains a bathroom with a toilet and shower.
The rear dining area converts to a bed, sleeping for two people.
The Scamp has many options:
1.9 cubic ft refrigerator
Two burner propane stove with cover
Hot water heater
Furnace (16,000 BTU)
Roof mount Air Conditioner (15,000 BTU)
12V and 120V hook up
City water connection
12 gallon freshwater tank on board
Plenty of closet space
New RV TV and antenna September 2021
Have all books and manuals
Interior is super clean. Body is in good condition.
This trailer was never lived in and has only been traveled in a few times.

domain: travel


text:
Every day until the end of February, we’ll highlight one of our favorite Korean rappers on a countdown to #1.
Cresting the top five list is the one, the only…
This might be a bit long. I reaaaaally love him.
So, something happened with Zico when I first listened that typically doesn’t happen with most groups/solo artists that I check out: I listened to exactly one Zico solo song and immediately knew I was going to stan.
Immediately his style stuck out to me, and his animated nature was as delightful to watch as it was to listen to.
Of all of the Korean rappers I’ve ever listened to, he is by far the most interesting and among the most animated alongside being among the most talented. I’d give a kidney to watch him record an entire album in-studio just to see how he gets into it.
On top of that, his voice knows no limits to the point where it almost sounds like a different person each song. In the same vein, no two Zico solo songs sound the same, not just vocally but musically and lyrically as well.
As for technical skill, he’s not lacking.
Quite the opposite.
Zico is among the fastest in the industry, able to rap 10.13 syllables per second–something only the rapper Flowsik can do.
This is faster than even BTS’ Min Yoongi and Stray Kids’ Changbin, who have been shown to be able to rap 9.38 syllables per second.
Pair that with his absolutely fucking wild delivery and flow plus his lyrical content, and you’ve got a recipe for one of the best Korean rappers.
Let’s look at him from a lyrical standpoint. While he doesn’t avoid love songs, not every single song in his catalogue is based around relationships.
Instead he writes songs like Artist, about not being too afraid to create, not letting self-doubt and a lack of confidence stop you from putting your art out there, professing that art is for literally everyone.
People who are about to die of boredom
People who can never be high class
People who scratch and get bumps
People who are gonna kill it, oh yes
How much longer are your heads gonna be noisy?
If you have deep knowledge on art
Let’s draw something
From now on
Turn every back to a blank canvas
Don’t think, just do, you’re holding the brush
You have the most sense when you’re in front of the mirror
Life is short
Art is long
Any Song is a deceptively dark tune whose lyrics pull something of a Pumped Up Kicks in that the music is peppy while the song is talking about something unexpectedly darker. In this case, existential awareness as age starts to creep up on him and his friends disappear.
Some are struggling, some are partying
I feel so sentimental, I want my youth back
It was so noisy and then one by one
They all leave
Why is everyone so down?
What’s the problem, say something
It’s so icy here
Is this the trend these days?
Why is everyone so boring?
Actually, I guess I’m the same
Tell me what I got to do
Hurry and turn on the bluetooth
Let’s get in our last spurt before it’s too late
Not a lot of time left in our twenties
Change into comfy clothes
In No You Can’t, he shows he’s not too shy to drop an aggressive, clever diss track:
Artists be pushing release dates instead of beats
Cause ZICO’s new track is about to drop
He’s also not afraid at taking controversial swipes at the industry and other artists, like in the song Say Yes or No:
There’s no one to really compare me with, I don’t use punch lines these days
Get out of my way, you newbies just quit trying to write songs
Just practice your dance moves, there’s no surgery for increasing skill
But I think one of the best examples of what I’m trying to describe here is his song ANTI, featuring GSoul.
ANTI is a meta-song about idol life, almost like an open letter to himself, asking why he puts up with the wild shit that kpop idols are expected to deal with.
He takes a cynical look at the lives of other idols, too, practically asking them the same question.
It isn’t often that super popular idols put out very specific social commentary songs (except for our queen Sunmi who doesn’t give a fuck and does so often, too).
When they do, it usually isn’t even this direct, blatant and raw.
Take a look at some isolated verses:
Celebrities are blinded by the spotlights
Deafened by the applause
So they see and hear but they can’t do anything
I’m not an anti its fan mail
Once you rack up those positive comments
That means you’re past your prime
If I cause some trouble right now, that’ll be nice timing
Preparing my mouth for some violent language
Our needs are simple, just need one sentence that’s off
Interpreting it is my job, I’ll decide the meaning
100 good deeds are on the sand
One error gets engraved on stone
The camera lens turns into a gun barrel
You should know
No matter how shitty things are for you, you need to dance properly
If you agree say yes
Listen, the moment you made your stage name, I had to kill you
It’s your choice
If you wanna succeed, you need to be criticized, get on the chopping block
Professionals always need to smile
You need to be judged to earn popularity
How can privacy exist in a product?
This place and its consumers are king
Keep your character in check, hide your face
That’s the reason you wear hats and masks
In all of the songs mentioned above, and the rest of his catalogue, for that matter, Zico talks about anything and everything and does so in a way that’s impossibly animated and fun.
When he talks shit, you feel like it’s personal.
When he’s encouraging you to create, you feel uplifted.
When he tells you to take a look at the world around you, you feel compelled to open up your eyes with tape on your eyelids and peer at the ugly truth.
For all of Zico’s absolute perfection, he makes it to #5 on our list of favorite Korean rappers this month.
Below, I’ve put together my favorite Zico tracks, including solos and features. I typically try to keep it limited to only five but that’s literally impossible with him. Sorry. But not really.
Check back tomorrow to see who comes in at #4!
ab6ix astro ATEEZ baekhyun blackpink bts chung ha cix cravity dreamcatcher DRIPPIN exo gidle golden child got7 hoppipolla ikon itzy iu Kang Daniel mamamoo MCND mirae MONSTA x nct Oh My Girl Oneus ONF OnlyOneOf Pentagon PIXY Purple Kiss Red Velvet Seventeen SHINEE stray kids Super Junior T1419 TRI.BE Twice Up10TION Verivery Victon WEi WJSN

domain: artistic


text:
Cheesy Hashbrown Casserole with Ham
Perfect for breakfast, brunch or dinner! Cheesy, scratch-made hashbrown casserole with diced ham and topped with cheddar cheese. Serve as a main course or as a hearty side.
Ingredients: Shredded potatoes (potatoes, disodium dihydrogen pyrophosphate (to promote color retention), dextrose), cheddar cheese (cheddar cheese (cultured pasteurized milk, salt, enzymes, color added, anticake (potato starch, powdered cellulose)), ham (ham cured with: water, dextrose, salt, potassium lactate, sodium phosphates, sodium diacetate, sodium erythorbate, sodium nitrite), onion, butter (cream, salt), all-purpose flour (enriched bleached wheat flour (contains bleached wheat flour, niacin, reduced iron, thiamin mononitrate, riboflavin, and folic acid), enzyme), milk, chicken stock (roasted chicken meat and chicken broth, salt, maltodextrin, hydrolyzed corn and soy protein, chicken fat, sugar, onion powder, yeast extract, disodium inosinate, disodium guanylate, turmeric, natural flavoring, annatto), sour cream (cultured cream), salt, pepper and thyme. Contains: wheat, milk, soy.

domain: food


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Not dead, just close.
Gnarr v1, for making dwarven battle cries.
Number four and a half reed has been released. It's apparently going to be featured in a Japanese Linux magazine or something. That makes me happy.
FreeD&D hasn't been progressing. Work, Joe. Work, Joe. Work, Joe.
Oh yeah, I've made some changes to Funbot, should probably release that.


AI stocks have been red hot in 2023, and AI will continue to be one of the hottest sectors for investors for the rest of the decade. However, there is some concern that some air is coming out of the AI bubble. And with lingering concerns about a recession, valuation worries are likely to grow.
That could lead investors to consider some AI-adjacent sectors to invest in. One of those would be robotics. Before AI caught the attention of investors, many companies were developing tools that were increasing business productivity by automating many tasks.
That’s an opportunity long-term investors can capitalize on. Here are three high-potential robotics investments to consider.
This post appeared first on InvestorPlace.


West Side looked like a different team in the second half on Tuesday night. After falling behind by five at halftime, the Eagles unloaded on Guy-Perkins in the third quarter, using a 21-2 run to seize control while gliding to a 91-77 win over the Thunderbirds.
The Thunderbirds, who were playing in their first game of the season, held a 47-39 lead early in the third period before West Side stormed in front, starting with a 7-0 spurt sparked by power forward Tyler Inman's bucket in the paint.
Guard Bryce Hipp added a pair of free throws then guard Jacob Miller drained a three-pointer as the Eagles pulled within one at 47-46 before Guy guard Cole Dixon sank two from the charity stripe.
Down 49-46, the Eagles unleashed a 14-0 run to take control as power forward Ben Hargrove scored inside then guard Blaine Hipp added a bucket off a back cut and assist from Hargrove.
West Side's game-changing run continued as Miller secured an offensive rebound and canned a 15-foot jumper from right baseline and Hargrove scored in transition off a smooth lob from Bryce Hipp.
Following a free throw by Bryce Hipp, forward Dalton Treece used a ball fake to get free and drilled a three-pointer up top. On the Eagles' next possession, Treece sank a midrange jump shot from left baseline off an assist from Inman.
“Kids did a good job of answering the bell in the second half,” said West Side Coach Shane Davis. “Sloppy first half ... 19 turnovers opposed to seven in second. We shot it really well and really got up and down the court well and I think really wore them down in the second half and had some kids really step up off the bench.
“We have to get better as far as taking care of the ball, 26 turnovers usually gets you beat but luckily our kids stepped up their defensive intensity in the second half, contested shots better, got the rebounds and converted really well on the offensive end. We got a battle coming up at Sacred very tough place to play Friday (today),” added Davis.
With West Side suddenly leading 60-49, the Thunderbirds closed the gap with six straight as guard Timothy Campbell hit two foul shots, Dixon swiped a steal and scored, then post player Jimmy Miller followed his own miss for a bucket.
Leading 60-55, West Side countered with seven straight, beginning when Hargrove pulled down a strong rebound and scored. Inman followed with a turnaround bank shot and Miller busted a three-pointer, pushing the Eagles' lead to 67-55 late in the third quarter.
The Eagles led 69-58 entering the fourth quarter but Guy trimmed its deficit to single digits on a 12-foot floater from left side by Campbell. Hargrove quickly answered in transition then Bryce Hipp scored four straight, including a spinning bank shot over two defenders.
Page 2 of 2 - Leading 73-63 early in the fourth quarter, West Side essentially put the game out of reach with four straight as Inman hit a well-defended turnaround shot from foul line and Blaine Hipp dropped a floater in the lane.
The Thunderbirds (0-1) opened the game on fire as Dixon scored 13 points in the first quarter. Utilizing its pressure defense, Guy built a 21-8 lead with a 12-0 run that started and ended with baskets by Campbell.
Trailing 27-18 after the first eight minutes of play, West Side opened the second quarter with an 8-0 spurt as Hargrove spun in the lane and hit a short jumper before Dalton Treece and Miller nailed back to back shots from beyond the arc.
Dixon's three-pointer from left corner gave the Thunderbirds a 38-29 lead midway through the second period, but West Side responded with a 10-0 run behind the consistent play of Bryce Hipp, who popped a deep three-pointer from right wing.
Bryce Hipp then split two defenders for a layup and moments later finished with a finger roll in transition. The Eagles took a brief 39-38 lead on a free throw by Hargrove and two more from Bryce Hipp.
But Dixon countered with a tough fall away, forward Cameron Davis hit a free throw and Campbell used a smooth crossover to shake a defender before dropping a floater while drawing contact. Campbell completed the three-point play with 6.4 seconds left in the first half, giving the Thunderbirds a 44-39 lead at intermission.
Campbell scored a game-high 28 points for Guy-Perkins, Dixon followed with 25 and guard Trey Davis added eight – all in the first quarter. The Thunderbirds finished 25 of 74 from the field, only hitting 8 of 40 shots in the second half.
Bryce Hipp paced West Side (2-0, which finished 33 of 57 from the field, including 7 of 18 from beyond the arc, with 23 points, six rebounds and eight assists.
Hargrove added 20 points and 11 rebounds, Miller had 11 points and five rebounds, Blaine Hipp racked up a triple double with 10 points, 11 rebounds and 10 assists, while Dalton Treece had nine points and Inman chipped in eight. The Eagles hit 7 of 18 free throws.


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12 December 1970
|Occupation||film director, film producer, actor|
Cheran (Tamil: சேரன்) is a Tamil film director from Madurai, Tamil Nadu, India. He has won the Indian National Film Award four – time for Vetri Kodi Kattu (2000), Autograph (2004), Thavamai Thavamirundhu (2005) and Aadum Koothu (2005) and four – time Tamil Nadu State Film Award for Best Director, and is a six-time Filmfare Award winner as well.
Cheran was born in Pazhaiyurpatty near Madurai. His father Pandian was a Projector Operator in Vellalur touring theatre. His mother Kamala was a primary school teacher. He has two sisters. His childhood dreams were all about the celluloid world. During his school days he acted in dramas.
He came to Chennai to pursue his career in films. Initially he started career as a Production manager in some movies. In the movie Puriyaadha Pudhir, he worked as an Assistant Director to Director K. S. Ravikumar. He was promoted as an associate director from Cheran Pandiyan to Nattamai. He made his directorial debut in Bharathi Kannamma a break to his film career through Producer Henry. The film met many controversies. In spite of it, the film was a big box office hit and gave a break to the sinking career of actor Parthiban. He became an over night star director. He gave a hat trick of successful films Porkkaalam, Pandavar Bhoomi, and Vetri Kodi Kattu. His movies concentrate strong social messages as the story base line. This director turned actor in Director Thangarbachan's film Solla Marandha Kadhai. His fame rose to dizzying heights in the film Autograph produced and directed by him. The film was screened four times at the Montreal Film Festival, Canada, an honour which he shares with Kamal Haasan and Maniratnam. He was thrilled by the standing ovation he received, when the show was over. With memorable films like Thavamai Thavamirundhu, he has also proved his acting versatility. He launched music company 'Dream Sounds' in 2013 which releases the audio of JK Enum Nanbanin Vaazhkai (or Yemito Ee Maaya) and Appavin Meesai.
|1997||Bharathi Kannamma||15 January 1997 / 175 days|
|1998||Porkkaalam||Still photographer||30 October 1997 / 150 days|
|Desiya Geetham||19 October 1998 / 85 days|
|2000||Vetri Kodi Kattu||30 June 2000 / 100 days|
|2001||Pandavar Bhoomi||21 September 2001 / 175 days|
|2002||Solla Marandha Kadhai||Sivadhanu||4 November 2002 / 100 days|
|2004||Autograph||Senthil||20 February 2004 / 175 days|
|2005||Thavamai Thavamirundhu||Ramalingam Muthiah||1 November 2005 / 100 days|
|2006||Azhagai Irukkirai Bayamai Irukkirathu||14 April 2006 / 25 days|
|2007||Maya Kannadi||Kumar||14 April 2007 / 25 days|
|Aadum Koothu||Gnanasekaran||(direct-to-video) 2005|
|2008||Pirivom Santhippom||Nadesan||14 January 2008 / 100 days|
|Raman Thediya Seethai||Venugopal||19 September 2008 / 100 days|
|2009||Pokkisham||Lenin||6-2009 / 35 days|
|2011||Yuddham Sei||J. Krishnamoorthi||4 February 2011 / 75 days|
|Muran||Nanda||30 September 2011 / 50 days|
|2013||Chennaiyil Oru Naal||Satyamoorthy||29 March 2011 / 100 days|
|Moondru Per Moondru Kaadhal||Gunasekar||1 May 2013|
|2014||JK Enum Nanbanin Vaazhkai||Ready to release|
|Yemito Ee Maaya||Made Bilingual with JK Enum Nanbanin Vaazhkai|
|Appavin Meesai||Post production|
|Kathai Thiraikathai Vasanam Iyakkam||Himself|
Awards and Honour
National Film Awards
- 2000 – National Film Award for Best Film on Other Social Issues for Vetri Kodi Kattu (Director)
- 2004 – National Film Award for Best Popular Film Providing Wholesome Entertainment for Autograph (Actor / Director)
- 2005 – National Film Award for Best Film on Family Welfare for Thavamai Thavamirundhu (Actor / Director)
- 2005 – National Film Award for Best Feature Film in Tamil for Aadum Koothu (Actor / Producer)
Tamil Nadu State Film Awards
- 1997 – Tamil Nadu State Film Award for Best Director for "Porkkaalam"
- 2000 – Tamil Nadu State Film Award for Best Dialogue Writer for Vetri Kodi Kattu
- 2004 – Tamil Nadu State Film Award for Best Director for Autograph
- 2005 – Tamil Nadu State Film Award for Best Film for Thavamai Thavamirundhu
- 1997 – Filmfare Award for Best Director – Tamil for Bharathi Kannamma
- 1997 – Filmfare Award for Best Film – Tamil for Bharathi Kannamma
- 1998 – Filmfare Award for Best Director – Tamil for Desiya Geetham
- 2001 – Filmfare Award for Best Film – Tamil for Pandavar Bhoomi
- 2001 – Filmfare Award for Best Director – Tamil for Pandavar Bhoomi
- 2004 – Filmfare Award for Best Director – Tamil for Autograph
- 2004 – Filmfare Award for Best Film – Tamil for Autograph
- 2004 – Dinakaran-Medimix Awards for Best film – Autograph
- 2004 – Dinakaran-Medimix Awards for Best Director – Autograph
- 2005 – Tamilnadu progressive writers association awards for Best Writer and Director – Thavamai Thavamirundhu
- 2011 – Jaya TV awards for Best actor – Yudham sei, Muran
Director / Actor / Producer has founded a new organization C2H Cinema2home, to curb out DVD PIRACY in Tamil Cinema Industry he says, This organisation is an revolution to Tamil Cinema Industry. Film maker Cheran clearly states that C2H will deliver official 5.1 HD Original DVD on the day of Theatrical release through C2H certified Distributors & Dealers he says, Cheran's JK Enum Nanbanin Vaazhkai First grand launch in Cinema2Home will be on 15/01/2015, followed by new Tamil films he says.
Director Cheran turns publisher with the Tamil novel Porum Valiyum (War & Pain). The novel is an emotional account of a war-torn Sri Lanka. The author Savitri Advithanandhan account was so touching that he decided that the book should reach all people. And as a first step, he launched the publishing house Cheran Noolagam.
- "Director Cheran pleads to rescue his daughter from her boyfriend". Kollytalk.com. Retrieved 24 December 2013.
- Double delight for Cheran. Oneindia.in. Retrieved 24 December 2013.
- "Simple narrative style gets "Autograph" a National Award". The Hindu. Retrieved 24 December 2013.
- AllIndianSite.com Cheran – It's all about Kollywood
- Cheran starts own Music Company

domain: entertainment


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domain: design


What are IEC Connectors?
Meet the Connector: IEC Connectors
IEC connectors or plugs are a broad category of power connectors for various uses that follow the International Electrotechnical Commission standards.
IEC connectors are not a specific type of connector. Instead, they are a broad category of different types of electronic and electrical power connectors that meet the International Electrotechnical Commission standards (IEC standards). These connectors serve many markets, including Medical, Consumer (white and brown goods), Industrial, Automotive, Transportation, Test & Measurement, and more. Hundreds of interconnect products are tested and standardized by the IEC, as well as capacitors, transformers, cables, sensors, fuses, and other components. IEC connectors are identified by a numerical system indicating the specific relevant standard.
IEC Connector Standards
- IEC 60130 Connectors for frequencies below 3 MHz
- IEC 60169Radio frequency connectors
- IEC 60320 Appliance couplers
- IEC 60339 General purpose rigid coaxial transmission lines and their associated flange connectors
- IEC 60457 Rigid precision coaxial and their associated precision connectors
- IEC 60498 High-voltage coaxial connectors used in nuclear instrumentation
- IEC 60512 Connectors for electronic equipment – Tests and measurements
- IEC 60603 Connectors for frequencies below 3 MHz for use with printed boards
- IEC 60803 Recommended dimensions for hexagonal and square crimping-die cavities, indentors, outer conductor crimp sleeves and center contact crimp barrels for RF cables and connectors
- IEC 60807 Rectangular connectors for frequencies below 3 MHz
- IEC 60828 Pin allocations for microprocessor systems using the IEC 60603-2 connector
- IEC 60874 Fiber optic interconnecting devices and passive components – Connectors for optical Fibers and cables
- IEC 61076 Connectors for electronic equipment – product requirements
- IEC TR 61141 Upper frequency limit of RF coaxial connectors
- IEC 61169 Radio frequency connectors
- IEC 61238 Compression and mechanical connectors for power cables for rated voltages up to 30 kV (Um = 36 kV)
- IEC 61274 Fiber optic interconnecting devices and passive components – Adaptors for Fiber optic connectors
- IEC TS 61586 Estimation of the reliability of electrical connectors
- IEC TR 61602 Connectors used in the field of audio, video, and audiovisual engineering
- IEC 61726 Cable assemblies, cables, connectors, and passive microwave components – Screening attenuation measurement by the reverberation chamber method
- IEC 61754 Fiber optic interconnecting devices and passive components – Fiber optic connector interfaces
- IEC 61755 Fiber optic interconnecting devices and passive components – Connector optical interfaces
- IEC 61984 Connectors – Safety requirements and tests
- IEC 62196 Plugs, socket-outlets, vehicle connectors and vehicle inlets – Conductive charging of electric vehicles
- IEC 62197 Connectors for electronic equipment – Quality assessment requirements
- IEC 63171-6:2021 covers 2-way and 4-way (data/power), shielded, free, and fixed connectors for data transmission with frequencies up to 600 MHz
- IEC 80369 Small-bore connectors for liquids and gases in healthcare applications
Many other IEC standards are highly relevant to connectors, particularly those that refer to cables and other connector-adjacent technologies. IEC 60038, which standardizes voltages, IEC 61760, which standardizes surface mounting technology, and IEC 60059, which standardizes current ratings are also central to interconnects.
- IEC standards are developed with input from industry and research institutions.
- IEC standards have often been adopted as national or regional standards; close to 80% of European electrical and electronic standards are in fact IEC International Standards.
- The IEC has a clear, strictly controlled standards development process. It governs the development and publication of IEC International Standards and reviews input from stakeholders at different stages of development.
- Testing to support IEC standards are transparent, predictable, comparable, and affordable.
- IEC standards help reduce trade barriers caused by different certification criteria in different countries.
- The IEC is prioritizing energy efficiency through several technical committees, with an emphasis on e-mobility systems, electricity supply infrastructure, self-driving technology, and in-vehicle multimedia systems.
- UL standards largely follow IEC standards.


text:
In his remarks to the House Financial Services Committee, Chair Gensler said the two-day settlement cycle was partially to blame for the trading freeze-out that some investors experienced at the height of the “GameStonk” market frenzy. Here’s an excerpt about that:
The longer it takes for a trade to settle, the more risk our markets assume. The good news is, though it will take a lot of work by many parties, we now have the technology to further shorten the settlement cycles, not only to the settlement cycle we had a century ago, but even to same-day settlement (T-0 or “T-evening”).
I believe shortening the standard settlement cycle could reduce costs and risks in our markets. I’ve directed the SEC staff to put together a draft proposal for the Commission’s review on this topic.
Chair Gensler isn’t the first or only person to raise this possibility. CII’s Research & Education Fund suggested in a paper last week that slow settlement times were a potential contributor to the GameStop frenzy. And although it was only 4 years ago that the SEC said “hasta la vista” to T+3 settlement, former SEC Commissioner Michael Piwowar – who was an enthusiastic supporter of that 2017 rule change – also argued in a February WSJ op-ed that the 2-day settlement period is now past its prime.
DTCC then issued a 14-page whitepaper to identify steps necessary to move toward a T+1 settlement period – by 2023. DTCC says:
We believe the opportunity exists to accelerate the settlement cycle and optimize the process further, to T+1, T+1/2 or someday, even netted T+0, in which trades are netted and settled at the end of the same trading day.
DTCC goes on to say that real-time settlement is unlikely. It would put market makers in the very tricky position of having to see into the future and know what their net obligations will be at the end of each day, and have enough shares or dollars to meet those obligations. They’d basically have to change all of their processes and move to a transaction-by-transaction system. Last week, the Investment Company Institute (ICI), the Securities Industry and Financial Markets Association (SIFMA), and DTCC issued a follow-up FAQ to reiterate what needs to be done to accelerate the settlement cycle, and why T+0 isn’t feasible for all trades. But with Chair Gensler’s remarks, they could be taking a closer look at those obstacles.
In addition, DTC might be facing some competition. Paxos Trust Company announced that it’s already using blockchain technology to achieve same-day settlement for some equity trades. Paxos has also applied for full clearing-agency registration with the SEC and hopes to be approved sometime this year.
If and when a shorter settlement cycle arrives, it’ll have the most impact on broker-dealer obligations. The 2017 amendments didn’t change the settlement cycle for securities sold in most cash-only, firm commitment underwritten offerings – as explained in a Skadden memo at the time – and settlement on public offerings is still all over the place. While most deals are at T+3 or even T+4, some debt issuers want to push out settlement even further so that interest doesn’t start accruing.
-Liz Dunshee, TheCorporateCounsel.net May 11, 2021

domain: law


text:
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Uproar in DA-led municipality as workers demand parity
SAMWU members at the DA-run Mookgophong-Modimolle municipality in Limpopo have called for the head of municipal manager, Phineas Sebola, following accusations that he trivializes their demands.
The union members have been demanding parity in salary across all departments in the municipality.
Shop steward Solly Teffo said that after the amalgamation of the two municipalities, SA Local Government Association (SALGA) made a presentation to the council, and an arrangement was made for parity to be introduced on 25 November 2017. He accused Sebola of dragging his feet in the implementation of parity.
Teffo also accused Sebola of “secretly”postponing a meeting to discuss the implementation of parity with the Mayor, Marlene van Staden, and SALGA: “The mayor [on the date of the meeting] decided to call SALGA to check if they will still make it to the meeting.
“That is when she was told that Sebola told them that the meeting was postponed. She then decided to call Sebola and check if what SALGA just told her was true, but he decided not to answer his phone and she tried that three times in our presence,” Teffo said.
Teffo claimed that Sebola was not in good terms with the Mayor and “he is fighting her at our expense, and he knew that should he defy the Council and SALGA, we will go on strike.”
“We as workers demand that Sebola must resign and if he doesn’t resign, we will call on the Council to dismiss him with immediate effect since he failed to comply with their ruling they made 12 months ago,” he said.
Several attempts to reach Sebola for comment failed.
But Van Staden blamed the collapse of the meeting on lack of communication within the municipality.
But explaining the situation at the municipality, she said: “SALGA has been to us two times already to help us with this whole project and the Council accepted everything in terms of the recommendations and the administration to implement that project.
“We then received a letter from SALGA on the 14 of November saying there were some processes that have not been completed and that is why they have been unable to implement the whole new salary structure.”
SALGA labour relations manager Dan Raseloma said: “SALGA is doing everything to remedy the situation at the municipality and we made a commitment to them that we will assist them with the process but there are some things which we need the municipality to make input on such as job descriptions which will be done through the process of job evaluations.”

domain: news


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When I was ten my dream was to work on Star Wars. Not only did I achieve my dream, but I worked on all six Star Wars films and I was even in Star Wars twice! My passion these days is to inspire your children to achieve their dreams and goals!
I will be holding an informational night at the Hamilton Community Center West Wing on Tuesday, May 8th from 6-8pm where you can find more information about my Summer offerings. Feel free to bring your kids. I will be having live demonstrations of the types of things your kids will learn to do over the Summer. I will also be offering a substantial discount to those who attend. Feel free to share this event with your friends and family, all are welcome.


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New figures to complete your A-team.
McFarlane Toys has released new images for The Walking Dead TV series 5 action figures. We’ve only seen concept arts previously, so it’s great to see images of the actual products.
This series is set to release in January for around $15 a piece. This set will include Tyreese, Maggie, Glenn, Merle Walker and Charred Walker.


text:
Beauty & Fashion
Got a hot tip?
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Diddy honoured the man who launched his career, Andre Harrell, in a new tribute following the music exec's tragic death last week.
It was a sad day for the music industry as a whole when the incomparable Andre Harrell passed away last week on May 7th. Diddy was hit especially hard by the legendary music executive's passing, though, due to the pivotal role Andre played in discovering a young Sean Combs and turning him into a superstar. A few days after the tragic news broke, Diddy took to Instagram to share a heartfelt tribute to his mentor, including a clip from an acceptance speech he gave in which he thanked Andre for all that he's done for him over the years. On Friday (May 15th), Diddy shared another beautiful message about the man who helped launch his career.
Diddy posted a photo of the two of them hugging on Instagram, along with some loving words. "Irreplaceable," he began, "I MISS YOU. HE WAS SO KIND. SO BEAUTIFUL. SO PATIENT. SO BLACK. SO CARING. SO SHARING. SO WISE. THE LIFE OF THE PARTY. A MUSICAL GENIUS! MY HERO. LOVE FOREVER."
Catherine McGann/Getty Images
Following Andre's passing, tons of artists and key players in the industry took to social media to pay their respects.
Rest in peace to a true legend.

domain: celebrity


nts – Free CEU Webinar: Duct Design & Performance (PDF Download)
Proper design of residential ventilation systems is essential for economic optimization of duct installation cost and ventilation fan power cost. This webinar discusses the characteristics of economically optimized residential ventilation systems. Just as important as the design is quality installation of ventilation ductwork. Two performance metrics and simple field tests are presented for determining the flow performance and leakage of a duct network. Flow performance and leakage tests should be performed before wallboard and ceiling panels are installed so that corrective action can be taken on substandard duct installation.
Webinar participants will:
This webinar is presented by Build Equinox, a leader in fresh air ventilation technology. Build Equinox manufactures the CERV smart ventilation system that automatically monitors and controls indoor pollutants in homes. The CERV is manufactured in Build Equinox’s solar powered facility located in Urbana, Illinois.