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Historic seasons stayed alive for two teams yesterday, and only a shocking upset in the next three weeks can deter the New England Patriots or Miami Dolphins from their respective destinies.
Week 14 offered the last best chance for the Patriots to be knocked off course from a 16-0 regular season. But quarterback Tom Brady lacerated the Pittsburgh Steelers' No. 1 defense for 399 yards and four touchdowns in a surprisingly one-sided 34-13 victory.
This also was the seeming last exit ramp for the Dolphins before they stagger home to 0-16 infamy. And if a 38-17 loss to the Buffalo Bills was any indication, the only team that previously had gone undefeated through an entire season also will become the first to go winless through 16 games.
Forget this "any given Sunday" stuff. The Patriots answered the Steelers' relentless blitzes with 46 passes and only nine rushes. There was no deception. New England came to pass, Pittsburgh came to blitz, and that was that.
The Patriots are even more one-dimensional on offense than the 2001 St. Louis Rams -- known as The Greatest Show on Turf -- who at least balanced Kurt Warner's passing with the running of Marshall Faulk.
There is no such balance in New England, just dominance. And the Patriots' defense, which looked vulnerable against the Ravens a week ago, shut out the Steelers in the second half after staking a 17-13 lead.
The road to perfection? The Patriots get the New York Jets -- won't Bill Belichick love running it up on Eric Mangini, the man who created Spygate? -- and Dolphins at home before finishing the regular season in New Jersey against the New York Giants. The only guesswork is in which game Brady, with 45 touchdown throws, will break Peyton Manning's 2004 single-season record of 49.
Looking to Week 17, might the Patriots pull their regulars with home-field clinched? Not a chance, not with history at their fingertips.
Miami will march to history with home games against the Ravens and Cincinnati Bengals around a trip to Foxborough, Mass. The Dolphins all but lay down in Buffalo yesterday, falling behind 31-7 in the second quarter. They will not beat anyone with that kind of effort.
Around the league
The Seattle Seahawks have been flying below the radar all season in the torpid NFC West. But they clinched the division title with a convincing 42-21 drubbing of the Arizona Cardinals when Matt Hasselbeck threw for four touchdowns. That's their ticket to a meaningful playoff run. If Hasselbeck gets hot, the Seahawks might have the ammunition to beat the Dallas Cowboys or Green Bay Packers in the NFC. If Shaun Alexander ever shows up, so much the better.
The Cowboys and Packers also earned division-clinching wins in Week 14. Dallas was less than impressive in struggling to beat the fading Detroit Lions, 28-27. Most disconcerting for the Cowboys was that their rushing defense gave up 152 yards to the Lions, who have great disdain for the run. The Packers toyed with the Oakland Raiders in a 38-7 romp in which Ryan Grant rushed for 156 yards.
If the playoffs started today, there would be three new teams in each conference in the tournament that weren't there last season. The Packers, Tampa Bay Buccaneers and Minnesota Vikings would be the new entries in the NFC. The Steelers, Jacksonville Jaguars and Cleveland Browns would be the three new teams in the AFC.
One of the toughest setbacks for any team yesterday was Tennessee's 23-17 overtime loss to the San Diego Chargers after leading 17-3 late at home. LaDainian Tomlinson (146 rushing yards, game-winning 16-yard touchdown run) bailed out the Chargers, who played poorly most of the day. The Titans battered San Diego (Antonio Gates, Shawne Merriman, Philip Rivers and Lorenzo Neal had to leave the game at least temporarily) but couldn't run out the clock when they needed to. Tennessee, which started 6-2, has dropped four of its past five to lose its grip on a wild-card spot. The Titans have a hard road now.
Cincinnati's 19-10 win over first-time starter Brock Berlin and the St. Louis Rams gives coach Marvin Lewis a shot at his fourth 8-8 season in five years with the Bengals. At 5-8, they have a reasonable chance to do that. Their last three games are against San Francisco, Cleveland and Miami. Lewis is 40-38, including the postseason, with one playoff appearance. In Cincinnati, mediocrity is pretty good.


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Russ Washington is a successful businessman on top of the world. But when Addiction, secrets, and faulty relationships send him spiraling down the rabbit hole, will he continue to plummet or find the strength to carry on.
Devon Carmichael loses his job, girlfriend and apartment all in one day. So what's he to do? Travel to California's elitist wine country with his best friend to get wasted and pick up chicks of course.
Hunter G. Williams
Get entertainment news, trailer drops, and photos with IMDb's coverage of 2017 San Diego Comic-Con featuring host and IMDboat captain Kevin Smith. Watch our exclusive celebrity interviews, and tune in to our LIVE show from 3:30 to 5 p.m. PDT on Saturday, July 22.
Lily Tomlin won the 1986 Tony Award for Best Actress in a Play for "The Search for Signs of Intelligent Life in the Universe" by Jane Wagner and recreated her performance for this filmed production. The original production opened on September 26, 1985 at the Plymouth Theatre, and ran for 391 performances. See more »
Flawed presentation of a brilliant, must see, one-woman show
Actually, far from a great film in terms of technique arbitrarily cross cutting between Lily Tomlin on stage, without costumes or sets (and oddly, also without an audience, but with over the top sound effects) and her playing the same characters in costumes and on sets (some naturalistic, some stylized).
For me it was a clunky and distracting approach.
However, the writing is so great and Tomlin's performance as her different characters is so memorable, so funny and so touching, that even a damaged version of this amazing one- woman show is better than none, by a long shot.
2 of 2 people found this review helpful.
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domain: artistic


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Hand Crafted African Ethnic Style Wood Pendant...
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domain: design


Multifunction cleaner CZZ100
Certification: ISO9000, CE, TUV
Multifunction cleaner CZZ100
[Functions and Features]
The multifunction cleaner(CZZ100) is our company’s patented product with the independent intellectual property, which can be used to remove big impurities, small impurities, light impurities,immature seeds, fluff and dust, meanwhile the heavy impurities like clod, stones, glass and metals can be sorted out properly from raw materials. It is mainly used for pre-cleaning industry of the agro products. It features low power consumption, compact structure,, little damage of materials and good effect of impurities removing.
The multifunction cleaner consists of sieve, cyclone dust collector, blower, plug-in plate discharger, vibratory motors, and structural frame, and shall be equipped with elevator if used individually.
Sunflower seeds, grass seeds, pumpkin seeds, sesame seeds
[Technical parameters ]
Power:2.94kw (380v 3 phase 50Hz)
Input capacity: 1.0-1.5mts/hour
% of heavy impurities cleaned: 99.8% min.
% of other impurities cleaned: 99%min.
Space occupied: 3.5m×2.8m
Jinzhou Qiaopai Machinery Co., Ltd. (Qiaopai Group) is professional manufacturer of complete processing line on cereals and oil seeds’ pre-cleaning, dehulling and separating, integrating scientific research with manufacturing, integrating sales and service. On basis of high technology with proprietary IPR, Qiaopai company dedicates itself to promoting agricultural industrialization and the automotion of agro-machineries in China.
The products of Qiaopai company mainly consists of following complete processing lines, including pre-cleaning,sizing,elevating,dehulling,separating, drying and roasting for sunflower seeds, pumpkin seeds and watermelon seeds, buckwheats, oats,beans, hazelnuts,almond, foxnut,rapeseeds and sesame seeds etc.Qiaopai company equipped with high precision CNC plasma cutting, CNC bending,CNC punching presses,and also diversified advanced machining equipment on turning,milling,planning and grinding. Besides well-equipped factory, we have high qualified R&D experimental team,over the years we have more than 110 national patents, and the number of patent-application has increased every year along with improvements and innovation of our manufactured equipments. Qiaopai products enjoy well confidence of customers both domestic and overseas due to products that we produce are strict controlled from each process, right from design,manufacturing, assembly and site commissioning. Besides this, we can also manufacture tailor-made processing line, according to customers’ different requirements of our equipment.Qiaopai will always keep on creating new standards, new product and new concept to meet customer needs.
Qiaopai company will always follow the quality and service policy: adhere to quality criteria, stick to scientific and technical innovation, provide excellent service,pursue the customer’s satisfaction. Qiaopai’s products have been exported to more than 40 countries around the world and most of provinces and autonomous regions in China. Under the constant endeavor of Qiaopai staff,Qiaopai is showing high&new-tech of our own and creating world famous brand of China.


Light blue - 4979/031
Lapel collar jacket with long cuffed sleeves. Front patch pockets and welt pockets. Frayed hem. Front metal button closure.
MODEL HEIGHT: 5’ 10” (177 cm)
Care for fiber: at least 65% ecologically grown cotton.
Ecologically grown cotton is grown with natural fertilizers and pesticides. Also, no genetically modified seeds are used in its cultivation which helps preserve seed biodiversity and soil fertility.


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Arnold schwarzenegger dating game Free webcam talk to horny girls
'I've never felt sick or had any symptoms at all, but I knew I'd have to take care of this condition sooner or later,' Schwarzenegger said in a statement after the operation, according to the Los Angeles Times.
As of late Friday afternoon, his condition following the operation was described as stable.According to the American Heart Association, the valve closes off the lower right chamber and opens to allow blood to be pumped from the heart to the lungs (through the pulmonary artery) where it will receive oxygen.It was reported earlier that the procedure was to replace an aortic valve.Ketchell later shared an update on the social media site and added that Schwarzenegger was "awake" and in "good spirits", even managing to poke fun at his famous catchphrase."Update: @Schwarzenegger is awake and his first words were actually 'I'm back', so he is in good spirits," Ketchell added.
The 70-year-old actor developed complications after an operation for a catheter valve replacement at Cedars-Sinai Hospital in LA on Thursday and the decision was taken by doctors to give him emergency open-heart surgery, according to in June to the middle of October, so I am in that," he said."I am looking forward to coming back as the T-800 model.
Schwarzenegger presents Byoung Chan of Korea with the winners trophy for the Arnold Amateur Bodybuilding event, during the Arnold Sports Festival Australia at The Melbourne Convention and Exhibition Centre on March 18Young and buff: Schwarzenegger poses during the 38th Cannes film festival (left), where he presented the documentary Pumping Iron.

domain: news


East Boulder County needed a voice. Like the colonials writing the first newspapers, that’s how it begun. Printed on an unconventional yellow piece of paper—a color the publisher chose because it was happy—the first issue of YS was delivered door-to-door on foot to 4000 homes. “I was just sticking it in mailboxes,” laughs publisher Shavonne Blades. “I did get yelled at for it, but you know how it goes.”
That workhorse drive is what fuels the creative people in the YS offices in Erie today. In the editorial realm, we aptly refer to a magazine issue as a “book” because of the content and design involved with it. Each book has a connective tissue between the story features. And that glue is Boulder County. When former editor-in-chief Andra Coberly first began, she knew her task, which, as she put it on day one, was “to make the people who live here feel cool about living here.” It’s a motto YS has delivered on since its onset: driving through blizzards, surviving the 500-year flood, and striving through 36-hour deadlines to deliver the monthly book you and I love so much.
The process of accomplishing that can sometimes turn us employees into cartoon characters. Ragtag salespeople, editors, and designers cut through the office like miniature whirlwinds going into the late hours. When Erik Maulbetsch was editor in the early 2000s, YS operated out of a three-bedroom apartment. At 3 a.m., he promptly fell out of a bunk bed he was sleeping in and onto the floor. The occasional midnight prank never hurts, either—the best pulled by an art director who shoved all the office chairs into a bathroom. But in the end, YS is comprised of the most driven people who make books.
“We sorted and distributed all the magazines for mailing ourselves,” says former art director Stephanie Mott, reflecting on YS’s early transitional years. “It’s rewarding to see what talented, motivated people can accomplish.” Today, the publication is an integral voice encompassing all of Boulder County and everything north of Denver under the yellow sun. So thank you, reader, for 150 issues filled with substantial people, and helping us inculcate to metropolitans that incredible stories are not proportional to a city’s size.
2000: The local coupon-cutter known as The Goldmine is hand-walked to 4000 homes in Erie.
2001: The Yellow Scene circulates 26,000 copies throughout East Boulder County. The inside cover shamelessly admits: “We intend to eventually take over the world, of course.”
2002 – 03: The publication continues growing its editorial mark in this Reader Digest-like format printing in full color.
2004 – 08: Distributing at 44,000 copies, the publication transitions into a full-size magazine to accommodate the enormous “Holiday Gift Guide.”
2009: Now with a circulation of 70,000, the newly rebranded Yellow Scene transitions into Boulder with “Best of the West.”
2011: The magazine branches out across the Front Range with Colorado Brides & Colorado Babies.


Do you gamble on digitalisation? A better approach to capitalise on your data
01 April 2022
The automotive value chain is under intense pressure to move towards digitalisation. Organisations are spending billions across a variety of areas, ranging from infrastructure to platforms to multiple applications. To fuel this vast transformation, we must effectively generate, organise, mine & analyse data — the most valuable “currency” we have available — to the highest degree possible.
This article was originally featured as the cover story in the April 2022 issue of EPDT magazine [read the digital issue]. And sign up to receive your own copy each month.
Here, Sam Jonaidi, Vice President, Enterprise Software, Automotive & Arturo Vargas, Solutions Marketing Manager, Transportation at software-centric T&M firm, NI explore why it’s so important that we turn our attention to data to cover the big bets being placed across the industry…
Despite heavy investments in IT (information technology) and OT (operational technology) by the automotive industry, we have witnessed varying degrees of success when it comes to harnessing the full value of data – especially the parametric data that’s generated in assembly, inspection and test processes. Such data is believed to be the richest and most directly indicative of product performance for automotive Tier 1 and OEMs (original equipment manufacturers). So, what explains the mixed results? Two problems are to blame:
1. A lack of focus on making data and its availability as important as functionality when designing workstations, labs, production lines and facilities.
2. The inability to connect data silos intra-company, as well as inter-company.
Prioritising data also supercharges operational performance (OpEx and CapEx), since we can utilise machine learning to preemptively increase yields, reduce scrap and enhance OEE (overall equipment effectiveness) – while OEMs enjoy benefits like full parametric traceability and preemptive recalls.
The value of data
Of the bevy of capital assets that organisations invest in, data is by far the most valuable and ubiquitous of them all. How then can this rich source of untapped insights also be the most neglected? As it turns out, deriving insights from data requires significant infrastructural investment. The Automotive Industry Association in Germany (VDA) projects that EUR 25 billion will be invested in digitalisation by 2024 – and that’s on top of the EUR 50 billion already anticipated to introduce new electric drive systems.
The investment is there; the need is there; and the understanding is there. Yet, something still feels off. Automotive innovators have increasingly understood the importance of using data to gain an advantage over their competitors, but they’ve found themselves frustrated with the lack of solutions that are right for their digital transformation strategy, and for harnessing value to meet their goals.
Figure 1. Variations occur and can signal imminent or future issues; connecting data from different dimensions turns suspicion into actionable insights
The World Economic Forum reported in 2016 that the digital transformation of the automotive industry would yield an estimated US $0.67 trillion of value for automotive players by 2025, with the core motivators being “greater efficiency” and “cost savings.” Five years later, the industry now realises that harnessing data is also key to accelerating reliability, safety and quality. The opportunity isn’t just operational efficiency. We now have a path to leveraging data to improve product performance in this critical moment:
• January 2021—Volkswagen recalled the e-Up due to faulty battery cells and the inherent short circuit or even fire risk.
• February 2021—Hyundai recalled 82,000 electric vehicles (EVs) following reports of battery malfunctions.
• July 2021—General Motors recalled almost 70,000 Bolt EVs due to fire risks.
As the complexity and computational capabilities of vehicles continue to increase, so too does the cost of these related recalls. The Hyundai recall had one of the highest per-vehicle recall costs, of US $11,000. These recalls continue to wreak havoc on a critical industry desperately trying to earn consumer trust in an immature technology. But why?
Because most digitalisation and smart manufacturing endeavors are still focusing on process — not product performance — and analysing data in silos, instead of holistically. These two critical evolutions are at the heart of the frustration with the lack of solutions. By the time you get the data, you’re looking at problems that have already occurred, instead of finding and solving them preemptively. So, what steps can you take to remedy this situation?
Focus on product performance & stop testing backwards
Every system and component in a vehicle passed some sort of test before entering the market. “Passing” meant that, compared to a defined set of specifications, it met enough criteria to move forward in the manufacturing process. The fundamental problem here is that you’re looking backwards by testing something that’s already made. This way of testing focuses on the process, and has become rudimentary when considering the huge complexity of modern automotive systems.
For example, an EV could be experiencing deteriorated range because of bad welding on the battery, software issues on the BMS, a faulty semiconductor, environmental circumstances, driving habits, a combination of those—the list continues. How do we find the root cause for this problem? Traditionally, we would gather all available information and investigate possible causes until we find the source – which could take months or years, cost millions, and possibly, lead to recalls.
Figure 2. Using the welding example, actionable insights are also delivered to the process & equipment, so they can automatically adjust to ensure product performance is consistently delivered
But what if you were to use all your data, at all stages, to the most granular level, to ensure your product will perform and not only pass? What if you could drive actionable insights as you’re doing this? To focus on product performance, we need to understand that when we test for pass/fail, we neglect important data that could reveal issues like variations in the process, diminished product capabilities or short-term failure risk. Most importantly, when a problem does occur, neglecting the product performance data is what forces us to seek the root cause after the fact and end up reworking or recalling.
Since the answer lives in the data, we can proactively test for product performance by connecting data across three relevant dimensions: technology; value chain; and lifecycle.
By connecting all this data from the different systems, across these dimensions, we can activate data analytics techniques to prevent problems, find the root cause on the fly and test for product performance – not only to pass/fail the product.
Connect data across dimensions to break silos
Modern cars comprise massive amounts of technology, from semiconductors to chips, modules, systems, and so on to the full vehicle. Each of these components is typically delivered by different companies within the supply chain, and each company has their own processes, quality checks, and of course, data. These suppliers ship to their customers only their passing products, which may or may not be the best performing ones, and this makes a difference.
Back to the EV example: we know that the quality of the welding in a battery cell impacts the electrical efficiency of the battery pack and consequently, the EV range and performance over its lifetime. The welding involves reliably binding thin, highly conductive, multilayer, dissimilar materials together, and the industry uses multiple joining technologies to maximise conductivity, such as laser welding. After the welding is done in a very precise, repeatable process, EV manufacturers perform a weld integrity test in production by measuring the resistance of the seam and deciding the pass/fail status within ranges of 0.1 mO.
To take such an example from testing for pass/fail to testing for product performance, let’s say we expect the measured resistance of the seam to follow a curve with the centre at 3.2 µO and acceptable variation range within 2.8 µO and 3.8 µO. We perform test in every weld and plot the results on a histogram (Figure 1). If the distribution starts moving, the welds will still pass for some time, but the shift shown by the data will indicate something is happening. Getting the insight before the test starts failing enables engineers to anticipate potential issues, but it’s not enough to start determining the root cause.
Let’s now extend the example and correlate the data to other dimensions, such as a recent change in the supplier of the shielding gas for the welding process, some aluminum oxide building up on the recently replaced probe, or an adjustment on the manufacturing process to speed up the welding. When you’re able to connect all this data on this multidimension data analytics solution, finding root causes, predicting quality and adjusting to meet product performance becomes a reality.
Figure 3. Connecting data across the different dimensions of a product reveals performance data and, with the right analytics tools, actionable insights to eliminate blind spots in the manufacturing process
Deliver actionable insights from the connected data
Connecting the data in the test context includes gathering, sanitising, tracing, linking, contextualising, associating and making it available to the data analytics engine, to then feed the actionable insights back to the right resource. In practice, it means having an eye, a brain and a hand on every parameter measured across the dimensions of the product (and on all of them collectively), and then acting on the insights automatically (Figure 2), as well as informing the stakeholders, so they have zero blind spots.
Turning test from a process that looks backwards into a process that looks at product performance as we manufacture it is an overwhelming challenge that sums up what digital transformation is about – and it requires leveraging data analytics, adaptive manufacturing, artificial intelligence and machine learning.
Despite how daunting this may seem, by doing so, you’re almost immediately able to draw value by connecting data in even one or two of the dimensions. By starting to break down, for example, data silos between the design, manufacturing and in-use product stages, we can make a difference in the value that data brings to our organisations (Figure 3).
You need data insights, not just data
At NI, we understand that companies are at different stages of digitalisation, so flexibility is of utmost importance to us. We have 40 years of expertise generating test data and helping automotive companies use it to ensure reliability, while meeting cost and times constraints.
At our core, we’re engineers who are passionate about enabling innovators to develop products that are more innovative, affordable and safer. Following that passion, the growing need to extract actionable insights drove us to expand from test data to all product data: throughout the product lifecycle, the technology and the supply chain. Through the acquisition of OptimalPlus, we added an established, prescriptive data analytics solution and integrated it across our test technology to help focus automotive efforts on making data-driven decisions and finding root causes, on the fly, so companies can deliver better performing products to market.
We believe that only by being intentional with your data strategy, and through the right analysis of impact and commitment to change, can you deliver the best products to the market. Implementing the NI approach to drive actionable insights from your data and preemptively solve problems is not a gamble on data analytics, but a solid step towards making data work for you to eliminate defects, recalls and waste and meet the fast pace of innovation towards Vision Zero.
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Organise your stationery in style with the colourful and vibrant Heron's Palace Desk Organizer from the house of India Circus. The design on this wooden home office storage and desk accessory features an artistic representation of Mughal-styled windows in a splash of orange and blue along with the Heron. The bird is seen relishing the serenity of the garden. Explore the entire range of desk Organizers online at India Circus.
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Escaped inmate worker back in custody, police say
The inmate was last seen traveling on Highway 58 in Roane County.
MONROE COUNTY, Tenn. (WVLT) - The Monroe County Sheriff’s Office announced Saturday that an inmate worker that escaped Friday was back in custody.
On Friday, Nov. 18, Ricky Lynn Burnette was assigned to the Monroe County Maintenance Department as an inmate worker. While on the job, he stole a 1997 silver Ford Ranger single cab truck with Tennessee tag 021BFVH and fled the scene, Sheriff Tommy Jones said.
Burnette was considered armed and dangerous because the maintenance employee had two personal handguns inside the truck when it was stolen, according to Jones.
On Saturday, Nov. 19, Jones said Burnette had been apprehended in Knox County. He was wanted for felony escape and motor vehicle theft.
“The Monroe County Sheriff’s Office would like to thank all of the local, state and federal law enforcement agencies that assisted in helping locate Mr. Burnette,” Jones said.
Copyright 2022 WVLT. All rights reserved.


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- Shrill: Notes from a Loud Woman (2016) by Lindy West
There are few times where I say, this book is wonderfully amazing and should be required reading for everyone, but this is one of those few times. This smart, deeply insightful, so, so personal and extremely well narrated (by the author if you listen to audio, simply fabulous) book illuminates the raw feelings of another person, leaving you to examine your own preconceived notions concerning the bodies of those around you.
2. You’ll Grow Out of It (2016) by Jessi Klein
A fantastic piece of non-fiction, and yet again, the audio was narrated so perfectly and with such wit and precise inflection, I heard her voice speaking to me inside my own brain. Her voice literally started to narrate my thoughts as if I was Fred Savage in the Wonder Years.
Audio aside, Klein, this complete stranger out of nowhere, makes her life so accessible and identifiable to the life of a 30-something middle-class woman who dates, works and maybe one day gets married, that you are in a constant state of saying, “me, too!” One of the most striking threads throughout the book was how incredibly funny she was without trying to be funny. She has an innate talent to make a point of the obvious that also simultaneously hilarious. I can’t wait for her next book.
3. A Natural History of Hell: Stories (2016) by Jeffrey Ford
It’s mind-boggling to me that Jeffrey Ford isn’t a household name in horror along with your Joe Hills, Stephen Kings or Shirley Jacksons. His short stories are surprisingly original, eerie, and thoroughly penetrate the psyche during the dark parts of the day. Some stories include that of an evil angel set in a desolate and isolating backdrop, a reanimated skeleton with a will of its own, and a devilishly quirky examination of clergymen as saint or sinner. A Natural History of Hell is a collection that you check out from your library for the first story, then purchase for the rest as you’ll no doubt need it close at hand when describing the stories to friends or family over the hot stuff.
4. Oh She Glows Everyday: Quick and Simply Satisfying Plant-Based Recipes (2016) by Angela Liddon
Her sequel to the first cookbook, Oh She Glows (2014), is of the same ilk of easy to make and delicious vegetarian and vegan-friendly recipes. One of the many to die for recipes–vegan mac and peas. The dairy-free cheese is confusingly delicious because it’s made with whole foods such as potatoes and carrots, but somehow the end result tastes like melty dairy cheese. Liddon’s recipes are simple but excitingly different (no crust of bread with iceberg lettuce and an ice cube, here), and you should just probably buy it.
5. We Should All Be Feminists (2014) by Chimamanda Ngozi Adichie
You really have no excuse not to read this book, it’s like, fifty pages long, and the pages themselves are small. During this transcript from a 2012 TEDx talk, Adichie ruminates about growing up in Nigeria and the sexism that she has faced due to its cultural norms. However, as you flip from page to page, you quickly realize that “its cultural norms” aren’t indicative of Nigeria, but of the planet. Her experiences are universal, and if I were ever to say that women are linked via one particular aspect, its by the discrimination we experience based on gender. Adichie, through concrete examples in her own life, so beautifully and succinctly in this teeny tome argues that sexism against women is thorough, and it affects both men and women alike. If you’re reading this, please read that book. Especially if you’re a man. Or if you voted for Trump. I have an extra copy at home, just ask.
6. My Best Friend’s Exorcism (2016) by Grady Hendrix
I was lucky enough to interview Grady Hendrix before its publication and has been described as “Heathers meets the Exorcist,” which is true in a general outline kind of way, an affluent high school and a group of girls with a possession thrown in, but it’s more meaty than a simple Heathers plot (no dis to the movie Heathers, Heathers is sublime). Here, we’re privy to the internal workings of high school friendship with all its platonic intense intimacy as expressed through the terrifying sojourn into adulthood. The culture of the 1980s background and how Hendrix recollects the time period is terrifically precise, sending you flying back in time to recall your own days of Aquanet and sweet Cherry Pie (get it, Warrant? Maybe a little Quiet Riot?).
7. When Breath Becomes Air (2016) by Paul Kalanithi
Published posthumously by his wife after being diagnosed with Stage IV lung cancer, New York based neurosurgeon Paul Kalanithi writes a terse but oh so weighty recollection of his life, specifically as a lover of the arts by examining the work of writers and scholars, seeking the secrets of life, death, virtue and morality. At times this book breaks your heart (especially when Paul’s wife Lucy finishes the last chapter after his passing), encouraging you to reflect on your own relationships, values, life, and how you, or if you, consider your death and if you will do that with grace. Paul makes a compelling case for grace, and though most of us may not so concretely meditate on our own passing, his call to action for a life well lived is what readers will most certainly take away.
8. My Life on the Road (2015) by Gloria Steinem
What can you say about Gloria Steinem that hasn’t already been said? The book is a fascinating recollection of the tales and trials of a life-long nomad, beginning with her childhood. She recounts her life as an organizer, an activist, a receiver of love, friendship, aggravation, struggle and hope. In Shrill, West tells you how she feels, and if you’re worth a damn, you listen. In My Life on the Road, Gloria talks about the importance of listening to those around you, ever changing, ever growing. She gives a damn and she empowers you to as well.
9. Wishful Drinking (2008) by Carrie Fisher
Due to the magnificence of technology in 2017, shortly after Debbie Reynolds passed I downloaded the audiobook of Wishful Drinking by Carrie Fisher immediately and for free (thanks library!). It’s a shitty thing, but I didn’t have the urge to read Carrie Fisher’s books until she died, justifying, I’m not a Star Wars fan. The real shame is that it wasn’t until after her death that I realized how completely bad ass she is. You can knock the book out in a day, so it’s a good primer on Fisher if you know very little about her. Plus, she narrates her memoirs so you get that perfectly timed and felt inflection. The book is comprised of brief anecdotes about her life relayed with the honesty, humor and incredulity that is (was) her life.
10. 99 Coffins (2007) by David Wellington
99 Coffins is the second in Wellington’s Vampire series and given the somewhat comical book jacket, there’s much more lurking behind the cover. Though I didn’t read the first in the series, I was able to catch up quickly with the plot. We’re set up with a run of the mill contemporary horror story: protagonist and state trooper Laura Caxton is hunting vampires. Wellington then expands the narrative by inserting historical fiction, the Civil War, alternating narratives, and an enchanting world where humans accept that vampires exist and that they are a bloody thirsty nuisance that needs to be checked. The novel is story based, teasing out the lives and therefore the motivations of the lead characters, as opposed to gratuitous violence as the book cover would suggest. The book is light, fun, thoroughly well-written and if you’re looking for a different sort of beach read, this is your gal. Highly recommended on audio, the narrator is wonderful.

domain: library


text:
Presented By: Beth Doerr
Event: West Africa Anglophone Forum 2015 (2015-03-26)
This workshop will explored ideas for irrigating vegetable gardens including ideas for homemade irrigation systems as well as factory made irrigation systems.
Beth has a B.A in International Agribusiness and is a former ECHO intern who returned to ECHO in 2004 after working for 13 years in community development. That time included 3 years at a vocational school in Malawi, 5 years as a consultant teaching gardening techniques using drip irrigation, and 3 years in Mauritania with World Vision. She shares her wealth of knowledge and experience with our overseas network by answering technical requests, specializing in the Moringa tree and Appropriate Technologies.

domain: agronomy


The ALPHA family of broadband seismometers is at the core of Gaiacode's geophysical instrumentation program. Based on a newly designed sensor, whose response to ground motion is governed by a double-nested feedback loop, the ALPHA seismometers are a versatile, low-noise family of seismic instruments. Being offered in various different versions ALPHAs can be used for all aspects of seismic measurements, from recording local and regional earthquakes to low frequency teleseismic studies.
ALPHA Surface/Vault version
The standard product of the ALPHA family is a low-noise seismometer designed to be deployed in vaults or shallow surface installations. Packaged in a rugged stainless steel vessel its three components are oriented in the classical orthogonal configuration, pointing into the three cardinal directions.
ALPHA Posthole Seismometer
The ALPHA Posthole Seismometer is designed to be buried under the most severe conditions. Its waterproof stainless construction with a special high pressure water tight connector allows installations in postholes or shallow boreholes down to 100 m depth.
ALPHA Light Seismometer
This ALPHA Light is a robust, lighter weight version of the standard surface/vault ALPHA seismometer. The weight reduction of roughly 30 percent is achieved by packaging this seismometer into a vessel made of anodized aluminium.
Digital ALPHA Seismometer
This digital version of the ALPHA family is essentially a stardard three-component ALPHA surface/vault instrument which is equipped with an internal 24-bit TAU digitzer. This integrated assembly gives the seismometer a true digital output.
ALPHA Borehole Seismometer
This borehole seismometer contains the three ALPHA sensors stacked on top of each other. Adding three SIGMA accelerometer sensors to the package makes this rugged instrument a cost effective multifunction seismic observatory with a dynamic amplitude range exceeding 200 dB.


But what is the use of it if it is not used? Your car may have something at first glance really useless on the chassis. This is why manufacturers do this: it looks useless but it is very useful.
We are used to thinking that if there is a particular product specific component On the subject, this is certainly crucial to his work. Many cars contain something useless that allows manufacturers to solve a very big problem, on an industrial scale: Don’t worry, it’s no reason to go to the mechanic to check the car!
Do you know when you buy a product to be assembled in this very popular Scandinavian store where there is generally furniture and things for the home? as the swedes They are highly savingAfter you’ve finished assembling your bed or wardrobe, you’ll find that a few pieces are left: what seems like a seemingly useless thing turns out to be a great way to save your day if you’ve missed an ingredient.
This anecdote – which also seems useless – has a purpose, which is to explain to you that when we talk about large companies that issue millions of euros a month, no details are left to chance. Likewise, there is one thing your car may not even have It will not affect in the least Operating your new car is proving to be an essential detail to help a car manufacturer go into production!
We work without it
The details we are talking about are not trivial: in fact, it is the exhaust pipe of your car. No, of course we do not say that the muffler Useless In a combustion car, let’s explain the concept further: Many modern cars, if you’ve noticed, have a fake exhaust pipe that goes into the bumper when the muffler is actually low, often pointing toward the floor.
A few years ago, non-electric car manufacturers – which don’t need an exhaust but we’ll come back to them in a bit – realized the futility of aligning the muffler with the rear bumper. This is an unnecessary expense and a distraction for workers who have to assemble cars in a few hours of their main task. I already understood where this letter is headed…
Electric cars, which will soon become the only cars that can be legally sold in Europe, do not need a muffler. In fact, if you saw a Tesla passing near you, you would notice They have no holes in bumper. Despite this, there are brands such as Porsche that give customers the opportunity to purchase an electric car with a fake muffler, a purely aesthetic detail that involves significant expenses.
The speech is actually It is very economical Because apparently, by avoiding aligning the car’s real exhaust with the hole in the bumper, manufacturers save hundreds of dollars per unit produced which, assuming the car is built with millions of units, includes very significant savings for the brand.
In short, the hole in the bumper of your car Useless In the most modern of models, it’s a simple aesthetic whim not to deprive your car of the details that have characterized automotive design for decades. But with the advent of electricity, even fake silencers are destined to disappear. Sorry but it’s progress, don’t blame us.
“Explorer. Devoted travel specialist. Web expert. Organizer. Social media geek. Coffee enthusiast. Extreme troublemaker. Food trailblazer. Total bacon buff.”


text:
RED TAIL ACRES LLC
This business is no longer available.
This information has been provided for your convenience and may no longer be valid.
74460 Memphis Ridge Rd
Since 2009, Red Tail Acres Llc has been providing Business Services At Non-commercial Site from Richmond. Red Tail Acres Llc has estimated annual revenues of $85,000.00 and also employs an estimated 2 employees.
by dandb on February 07, 2016 from
Privacy & Terms

domain: economics


text:
Nautical Baby Mobile - Sailboat Anchor Wheel Lighthouse - Navy White Pink
This nursery mobile is a great touch for the nautical-themed baby nursery or for a child's room to add that whimsical sailing touch. Makes a great nautical baby shower gift idea or new parent gift, too!
• Includes three (3) hand-painted anchors, lighthouses, sailboats and ship wheels
• Suspended from the ceiling using a wooden ring and ribbon.
• Overall dimensions approximately 12"W x 30"H
• Each wooden piece measures approximately 3”L x 3"W
All our mobiles are MADE TO ORDER. Please include your choices in the notes field upon checkout if different than shown. There may be additional fees for additional colors or any personalization.
Mobiles are ornamental and for decorative purposes only. Please fasten securely to the ceiling and out of reach of children as they are not a toy.
This is an original design by FLUTTER BUNNY BOUTIQUE, LLC © 2013-2016
Copying and/or reproducing is strictly prohibited.


text:
Explore the world of peptides through our Peptides Learning Repository, a treasure trove of peptide-related knowledge.
Overview of Peptide-Based Anti-Malaria Agents: An Introduction to their Role in Treating Malaria
Peptide-based agents have emerged as a promising approach for treating malaria, a life-threatening parasitic disease transmitted by mosquitoes. These agents are designed to target specific proteins or pathways involved in the parasite’s lifecycle, making them effective against various stages of the infection. By disrupting essential processes within the parasite, peptide-based agents can inhibit its growth and replication, ultimately leading to its elimination from the host.
The significance of exploring peptide-based agents lies in their potential to overcome the limitations associated with traditional malaria treatments. While antimalarial drugs have been the primary treatment option, issues such as drug resistance and limited efficacy against certain strains of the parasite have become major challenges. Peptide-based agents offer a new avenue for combating malaria by providing alternative mechanisms of action and potentially reducing the development of drug resistance.
Understanding how these agents work at a molecular level is crucial for developing effective treatments. By targeting specific proteins or pathways essential for the parasite’s survival, peptide-based agents can disrupt vital processes such as DNA replication, protein synthesis, or cell invasion. This targeted approach minimizes damage to host cells and reduces side effects commonly associated with traditional antimalarial drugs.
Understanding Malaria: A Synopsis of the Disease and its Transmission
Malaria is a mosquito-borne infectious disease caused by parasites of the Plasmodium genus. It is transmitted through the bite of infected female Anopheles mosquitoes. Once inside the human body, the parasites multiply within liver cells before infecting red blood cells, leading to symptoms such as fever, chills, fatigue, and anemia. In severe cases, malaria can cause organ failure and death.
Malaria has a significant global impact, particularly in tropical and subtropical regions where transmission rates are highest. According to the World Health Organization (WHO), there were an estimated 229 million cases of malaria and 409,000 deaths in 2019 alone. The burden of the disease falls disproportionately on children under the age of five and pregnant women.
The need for effective treatments against malaria is evident due to its devastating impact on public health and socioeconomic development. Traditional control measures such as insecticide-treated bed nets and indoor residual spraying have helped reduce transmission rates, but they are not sufficient to eliminate the disease entirely. Developing novel treatment options like peptide-based agents is crucial for achieving malaria control and elimination goals.
Traditional Malaria Treatments: An Assessment of Limitations and Challenges
Currently, antimalarial drugs are the mainstay of malaria treatment. These drugs target the parasite at different stages of its lifecycle, aiming to kill or inhibit its growth within the human body. However, there are several limitations associated with traditional malaria treatments:
1. Drug Resistance: The emergence and spread of drug-resistant strains of Plasmodium parasites have significantly hampered the effectiveness of antimalarial drugs. Resistance to commonly used drugs such as chloroquine and sulfadoxine-pyrimethamine has been observed in many regions, making treatment more challenging.
2. Side Effects: Antimalarial drugs can cause a range of side effects, including nausea, vomiting, headache, dizziness, and skin rashes. In some cases, these side effects can be severe or life-threatening.
3. Limited Efficacy Against Certain Strains: Some strains of Plasmodium parasites have developed resistance to multiple antimalarial drugs simultaneously, limiting treatment options in affected areas.
4. Compliance Issues: Completing a full course of antimalarial treatment is essential for ensuring complete parasite clearance and preventing relapse. However, adherence to treatment regimens can be challenging due to factors such as access to healthcare facilities or patient education.
Addressing these limitations requires exploring alternative treatment approaches such as peptide-based agents, which offer the potential for improved efficacy and reduced drug resistance.
The Mechanism of Action: How do Peptide-Based Malaria Agents Work?
Peptide-based malaria agents work by targeting specific proteins or pathways within the parasite responsible for causing malaria. These agents are composed of short chains of amino acids, similar to those found naturally in the body. By mimicking or interfering with key interactions between proteins, peptide-based agents disrupt essential processes required for the parasite’s survival and replication.
The mode of action of peptide-based agents can vary depending on their specific target within the parasite. Some peptides may inhibit enzymes involved in DNA replication, preventing the parasite from multiplying within host cells. Others may interfere with protein synthesis or disrupt cell invasion mechanisms, preventing the parasite from infecting healthy red blood cells.
One example of a peptide-based agent is a class known as antimicrobial peptides (AMPs). These peptides have broad-spectrum activity against various pathogens, including Plasmodium parasites. AMPs can disrupt the integrity of the parasite’s cell membrane or interfere with vital metabolic processes, leading to its destruction.
Understanding the precise mechanisms by which peptide-based agents interact with the parasite is crucial for optimizing their effectiveness and minimizing potential side effects. Ongoing research aims to further elucidate these mechanisms and identify new targets for peptide-based interventions.
Evaluating Effectiveness: Clinical Trials and Studies on Peptide-Based Malaria Agents
Several clinical trials and studies have been conducted to assess the effectiveness of peptide-based malaria agents in treating the disease. These trials aim to evaluate factors such as efficacy, safety profile, and pharmacokinetics/pharmacodynamics. Here are some key findings from recent studies:
1. Efficacy: In a phase II clinical trial conducted in malaria-endemic regions, a peptide-based agent showed promising results in reducing parasite burden and improving clinical outcomes compared to standard antimalarial treatment. The peptide-based agent demonstrated efficacy against both drug-resistant and non-resistant strains of Plasmodium parasites.
2. Safety Profile: The safety profile of peptide-based agents has been generally favorable, with minimal side effects reported in clinical trials. Common adverse events include mild injection site reactions or transient gastrointestinal symptoms. However, long-term safety data and larger-scale trials are still needed to fully assess their safety profile.
3. Pharmacokinetics/Pharmacodynamics: Studies have shown that peptide-based agents can be administered via various routes, including oral, intravenous, or subcutaneous administration. Their pharmacokinetic properties allow for targeted delivery to the parasite while minimizing systemic exposure and potential toxicity.
These findings highlight the potential effectiveness of peptide-based malaria agents as alternative treatments for the disease. Further research and larger-scale trials are needed to validate these results and optimize their use in clinical practice.
Advantages over Traditional Treatments: Exploring Potential Benefits
Peptide-based malaria agents offer several potential advantages over traditional antimalarial drugs:
1. Reduced Drug Resistance: Peptide-based agents target specific proteins or pathways within the parasite, making it more difficult for the parasite to develop resistance compared to broad-spectrum antimalarial drugs.
2. Enhanced Specificity: By selectively targeting essential processes within the parasite, peptide-based agents minimize damage to host cells and reduce side effects commonly associated with traditional antimalarial drugs.
3. Potential Synergy with Existing Treatments: Peptide-based agents can be used in combination with other antimalarial drugs or therapies to enhance treatment outcomes. This approach may help overcome drug resistance and improve overall efficacy.
4. Broader Activity Spectrum: Some peptide-based agents have shown activity against multiple stages of the parasite’s lifecycle, including both liver-stage and blood-stage infections. This broader activity spectrum increases their potential utility as preventive measures or treatments for different stages of malaria.
5. Novel Mechanisms of Action: Peptide-based agents offer unique mechanisms of action compared to traditional antimalarial drugs, allowing for the exploration of new targets and pathways within the parasite. This diversity in mechanisms increases the chances of finding effective treatments against drug-resistant strains.
These potential benefits make peptide-based malaria agents an exciting area of research with the potential to revolutionize malaria treatment and control efforts. Continued research and development in this field are essential for harnessing their full potential.
Challenges in Developing Peptide-Based Anti-Malaria Agents: Current Roadblocks and Future Perspectives
While peptide-based agents show promise as anti-malarial treatments, several challenges need to be addressed for their successful development:
1. Stability and Formulation: Peptides can be susceptible to degradation or instability, limiting their shelf-life and formulation options. Overcoming these challenges requires innovative strategies such as peptide modifications or encapsulation techniques to enhance stability.
2. Delivery Systems: Efficient delivery systems are needed to ensure optimal bioavailability and targeted delivery of peptide-based agents to the site of infection. Strategies such as nanoparticle-based formulations or conjugation with targeting moieties can improve their pharmacokinetic properties.
3. Cost-effectiveness: Developing peptide-based agents can be costly due to the complexity involved in their synthesis, purification, and formulation. Ensuring cost-effectiveness is crucial for making these treatments accessible in resource-limited settings where malaria burden is high.
4. Regulatory Approval: The regulatory approval process for novel anti-malarial treatments can be lengthy and complex. Streamlining regulatory pathways specific to peptide-based agents could accelerate their development and availability.
Despite these challenges, ongoing research efforts aim to address these roadblocks through innovative approaches such as rational design strategies, advanced drug delivery systems, and collaborative partnerships between academia, industry, and global health organizations.
Combination Therapies: Enhancing Efficacy through Synergistic Approaches
Combination therapies, which involve the simultaneous use of multiple drugs or treatment modalities, have been successful in improving treatment outcomes for various infectious diseases, including malaria. Combining peptide-based agents with other antimalarial drugs or therapies holds promise for enhancing efficacy and overcoming drug resistance. Here are some potential benefits of combination therapies:
1. Synergistic Effects: Peptide-based agents may have complementary mechanisms of action when combined with traditional antimalarial drugs. This synergistic effect can enhance parasite clearance and reduce the risk of treatment failure.
2. Delaying Drug Resistance: By using multiple drugs with different targets, combination therapies can delay the emergence and spread of drug-resistant strains of Plasmodium parasites.
3. Improved Patient Compliance: Combination therapies can simplify treatment regimens by reducing the number of individual drugs required. This simplification improves patient compliance and adherence to treatment, leading to better overall outcomes.
4. Targeting Multiple Stages of Infection: Peptide-based agents may target specific stages of the parasite’s lifecycle, while traditional antimalarial drugs primarily focus on blood-stage infection. Combining these treatments allows for a comprehensive approach to targeting different stages of malaria.
The development and optimization of combination therapies require careful consideration of drug interactions, dosing regimens, and potential side effects. Well-designed clinical trials are needed to evaluate the safety and efficacy of these combinations in diverse malaria-endemic settings.
Safety Considerations: Assessing the Side Effects and Toxicity of Peptide-Based Malaria Agents
Ensuring the safety profile of peptide-based malaria agents is crucial for their successful development as anti-malarial treatments. While these agents have shown promising results in terms of efficacy, it is important to assess any potential side effects or toxicity concerns. Here are some key considerations:
1. Preclinical Safety Studies: Before advancing to clinical trials, extensive preclinical studies are conducted to evaluate the safety of peptide-based agents. These studies assess factors such as acute toxicity, genotoxicity, and potential effects on vital organs.
2. Clinical Trials: Phase I and II clinical trials are conducted to evaluate the safety profile of peptide-based agents in humans. Adverse events or side effects are carefully monitored and documented during these trials.
3. Dose Optimization: Determining the optimal dose range for peptide-based agents is essential to balance efficacy with safety. Dose escalation studies help identify the highest dose that can be administered without causing unacceptable toxicity.
4. Long-Term Safety Monitoring: Long-term safety data are crucial for assessing any potential delayed or cumulative toxicities associated with peptide-based agents. Post-marketing surveillance and pharmacovigilance systems play a vital role in monitoring their safety once they are approved for use.
It is important to note that while peptide-based agents have shown favorable safety profiles in clinical trials, continued monitoring and surveillance are necessary to detect any rare or long-term adverse effects that may arise with broader use.
Pharmacokinetics and Pharmacodynamics: Understanding Drug Absorption and Distribution
Understanding the pharmacokinetic and pharmacodynamic properties of peptide-based malaria agents is essential for optimizing their dosing regimens and ensuring therapeutic efficacy. Here are key considerations:
1. Bioavailability: Peptide-based agents can be administered via various routes, including oral, intravenous, or subcutaneous administration. Evaluating their bioavailability helps determine the most effective route of administration.
2. Absorption: Peptides can face challenges related to poor oral absorption due to their susceptibility to enzymatic degradation in the gastrointestinal tract. Strategies such as prodrug formulations or nanoparticle encapsulation can enhance their absorption.
3. Distribution: Peptide-based agents need to reach target tissues effectively to exert their therapeutic effects against the parasite. Assessing their distribution within the body helps optimize dosing regimens and ensure sufficient exposure to the parasite.
4. Metabolism and Elimination: Understanding the metabolism and elimination pathways of peptide-based agents is crucial for determining their half-life, potential drug interactions, and dosing frequency. This information guides dosing regimens and helps avoid toxicity or suboptimal efficacy.
Pharmacokinetic and pharmacodynamic studies provide valuable insights into the behavior of peptide-based agents within the body, allowing for informed decision-making regarding their use in clinical practice.
Targeting Different Stages of Malaria: Peptide-Based Agents for Prevention and Treatment
Peptide-based agents show promise in targeting various stages of malaria, making them suitable for both prevention and treatment strategies. Here are some key considerations:
1. Liver-Stage Infection: Some peptide-based agents can target the liver-stage infection of Plasmodium parasites, preventing the development of blood-stage infection. These agents have potential applications as prophylactic treatments or vaccines against malaria.
2. Blood-Stage Infection: Peptide-based agents can also target the blood-stage infection, where parasites multiply within red blood cells. By disrupting essential processes required for parasite survival during this stage, these agents can effectively treat established infections.
3. Gametocyte Transmission: Targeting gametocytes, the sexual forms of Plasmodium parasites responsible for transmission between humans and mosquitoes, is crucial for malaria control efforts. Peptide-based agents that specifically target gametocytes can help reduce transmission rates by preventing their development or disrupting their viability.
4. Drug-Resistant Strains: Peptide
Future Directions: Emerging Trends in Peptide-Based Anti-Malaria Research
Exploring Novel Peptide Structures
The future of peptide-based anti-malaria research lies in the exploration and development of novel peptide structures. Scientists are continuously investigating new peptide sequences and modifications that can enhance the efficacy and specificity of these agents against malaria parasites. By utilizing advanced computational methods and high-throughput screening techniques, researchers are able to identify promising peptide candidates with unique structural features. These emerging trends in peptide design hold great potential for the development of more potent and selective anti-malaria agents.
Targeting Drug-Resistant Malaria Strains
Another important direction in peptide-based anti-malaria research is the focus on targeting drug-resistant malaria strains. As resistance to conventional antimalarial drugs continues to pose a significant challenge, peptides offer a promising alternative due to their distinct mechanisms of action. Researchers are actively studying the interactions between peptides and drug-resistant malaria parasites to identify specific targets that can be exploited for therapeutic purposes. This approach not only provides hope for overcoming drug resistance but also contributes to the global effort in combating malaria.
The Role of Nanotechnology
Nanotechnology has emerged as a key player in advancing peptide-based anti-malaria research. By incorporating peptides into nanoscale delivery systems, such as nanoparticles or liposomes, researchers can improve their stability, bioavailability, and targeted delivery to infected cells. This innovative approach allows for controlled release of peptides at the site of infection, maximizing their therapeutic potential while minimizing side effects. The integration of nanotechnology with peptide-based therapies represents an exciting avenue for future research and holds promise for revolutionizing malaria treatment strategies.
- peptide structures
- computational methods
- high-throughput screening techniques
- potent and selective anti-malaria agents
- targeting drug-resistant malaria strains
- distinct mechanisms of action
- interactions between peptides and drug-resistant malaria parasites
- nanotechnology in peptide-based anti-malaria research
- nano delivery systems
- controlled release of peptides
- malaria treatment strategies
Cost-effectiveness Analysis: Assessing the Economic Impact of Peptide-Based Malaria Agents
Evaluating Treatment Costs and Outcomes
A crucial aspect of assessing the cost-effectiveness of peptide-based malaria agents is evaluating their treatment costs and outcomes. This involves analyzing the expenses associated with developing, manufacturing, and distributing these agents, as well as estimating the potential savings in healthcare expenditure resulting from their use. Additionally, it is important to consider the impact on patient outcomes, such as reduced hospitalization rates, improved quality of life, and decreased mortality. By conducting comprehensive cost-effectiveness analyses, policymakers and healthcare providers can make informed decisions regarding the integration of peptide-based malaria agents into existing treatment protocols.
Comparative Analysis with Conventional Antimalarial Drugs
To determine the economic impact of peptide-based malaria agents, a comparative analysis with conventional antimalarial drugs is essential. This involves evaluating factors such as drug pricing, treatment duration, adverse effects, and long-term efficacy. By comparing the costs and benefits of both approaches, researchers can assess whether peptide-based agents offer a more cost-effective solution for malaria treatment. Furthermore, considering the potential for drug resistance development with conventional drugs, it is crucial to account for the long-term economic implications when assessing the cost-effectiveness of peptide-based alternatives.
Societal Benefits and Cost Savings
In addition to direct healthcare costs, it is important to consider the societal benefits and cost savings associated with peptide-based malaria agents. These agents have the potential to reduce the burden of malaria on affected communities, leading to improved productivity, increased educational attainment, and enhanced economic development. By preventing illness and reducing transmission rates, peptide-based agents can contribute to long-term cost savings by minimizing the need for expensive healthcare interventions and control measures. Incorporating these broader societal impacts into cost-effectiveness analyses provides a more comprehensive understanding of the economic benefits associated with peptide-based malaria agents.
- treatment costs and outcomes
- expenses associated with developing, manufacturing, and distributing
- savings in healthcare expenditure
- patient outcomes
- comparative analysis with conventional antimalarial drugs
- drug pricing
- treatment duration
- adverse effects
- long-term efficacy
- societal benefits and cost savings
- reduced burden of malaria on affected communities
- improved productivity and economic development
Regulatory Challenges: Addressing Approval Processes for Peptide-Based Anti-Malaria Agents
Evidence Generation for Safety and Efficacy
One of the key regulatory challenges in approving peptide-based anti-malaria agents is generating sufficient evidence regarding their safety and efficacy. This involves conducting rigorous preclinical studies to evaluate their toxicity profiles, pharmacokinetics, and therapeutic effectiveness. Additionally, well-designed clinical trials are necessary to assess their performance in real-world settings. By adhering to established regulatory guidelines and providing robust scientific data, researchers can address concerns related to the safety and efficacy of peptide-based agents, paving the way for their approval.
Effective collaboration between researchers and regulatory authorities is crucial in navigating the approval processes for peptide-based anti-malaria agents. By fostering open communication and knowledge exchange, researchers can gain insights into the specific requirements and expectations of regulatory agencies. This collaboration allows for early identification of potential regulatory hurdles and facilitates the development of strategies to address them proactively. Furthermore, engaging regulatory authorities in the research process enhances transparency and trust, ultimately expediting the approval timeline for peptide-based anti-malaria agents.
Harmonization of Regulatory Standards
To streamline the approval processes for peptide-based anti-malaria agents, there is a need for harmonization of regulatory standards at an international level. Currently, variations in regulations across different countries can create barriers to global access and hinder timely approvals. By establishing common guidelines and frameworks, regulatory authorities can promote consistency in evaluating the safety, quality, and efficacy of peptide-based agents. This harmonization not only accelerates the approval process but also ensures that patients worldwide have equitable access to these potentially life-saving treatments.
- evidence generation for safety and efficacy
- rigorous preclinical studies
- toxicity profiles
- well-designed clinical trials
- collaboration between researchers and regulatory authorities
- specific requirements and expectations of regulatory agencies
- early identification of potential regulatory hurdles
- harmonization of regulatory standards
- variations in regulations across different countries
- common guidelines and frameworks
- safety, quality, and efficacy evaluation
The Promising Role of Peptide-Based Anti-Malaria Agents in Global Health Efforts
Peptide-based anti-malaria agents hold immense promise in global health efforts aimed at combating malaria. Through ongoing research on emerging trends, such as exploring novel peptide structures and targeting drug-resistant strains, scientists are continuously advancing the field. The integration of nanotechnology further enhances the potential of peptide-based therapies by improving their stability and targeted delivery.
Assessing the cost-effectiveness of these agents is crucial for their successful implementation. Evaluating treatment costs, comparing with conventional antimalarial drugs, and considering societal benefits provide a comprehensive understanding of their economic impact. By demonstrating their affordability and long-term benefits, peptide-based agents can garner support from policymakers and healthcare providers.
Addressing regulatory challenges is essential to ensure timely approval and global access to peptide-based anti-malaria agents. Generating robust evidence for safety and efficacy through preclinical studies and clinical trials is vital in meeting regulatory requirements. Collaboration between researchers and regulatory authorities facilitates knowledge exchange, early identification of hurdles, and trust-building.
peptide-based anti-malaria agents have the potential to revolutionize malaria treatment strategies. Their unique mechanisms of action, combined with advancements in research, make them promising candidates for overcoming drug resistance. By addressing economic considerations and navigating regulatory processes effectively, these agents can contribute significantly to global health efforts in eradicating malaria.
peptide-based anti-malaria agents hold significant potential in the fight against malaria due to their unique properties and mechanisms of action. These agents offer promising alternatives to traditional treatments, overcoming issues such as drug resistance and limited efficacy. With further research and development, peptide-based anti-malaria agents could revolutionize malaria treatment and contribute to global efforts in eradicating this deadly disease.
Common Queries and Answers September 2023
Is ivermectin anti malarial?
Ivermectin is commonly used in large-scale drug administrations to control parasitic diseases that are often overlooked, and it has the ability to kill malaria-carrying insects that come into contact with treated individuals. As a result, it has the potential to be a new method for reducing the spread of plasmodium, the parasite that causes malaria.
Which is natural antimalarial agent?
Natural products have played a vital role in improving human health, particularly in the treatment of malaria. The use of natural products such as quinine and artemisinin and their variations have been instrumental in saving countless lives.
How do antimicrobial peptides work?
Typically, antimicrobial peptides work by either damaging the outer membrane of bacteria or entering the bacterial cells to interact with internal components.
Which is the best medicinal plants for treatment of malaria at global level?
Some of the most frequently used plants in traditional medicine for treating malaria are Alstonia scholaris (L.) R. Br., Carica papaya L., and Andrographis paniculata (Burm.).
Which is plant based antimalarial?
Artemisinin is a powerful antimalarial compound extracted from the Artemisia annua plant. It is commonly used, along with its synthetic derivatives like artemether, artether, and artesunate, in areas where resistance to other antimalarial drugs has become a problem.
What are the four classes of antimalarial drugs?
The four primary categories of drugs used for the treatment of malaria are quinoline-related compounds, antifolates, artemisinin derivatives, and antimicrobials.
Discover the Power of Peptides: Your Ultimate Resource 2023
Discover a variety of peptide forms, including peptide structures, peptide assortments, extended IGF-1, Melanotan formulations, and beauty peptide substances at our Peptides Vendor. Our Buy Peptides Online platform provides in-depth resources for those interested in peptide science. We also offer a selection of Laboratory Materials for your research needs. Our Peptides Knowledge Center is a great resource for expanding your understanding of peptides.
Cite this Article
Estimated Reading Time: 21 min read
Table of Contents
- 1 Overview of Peptide-Based Anti-Malaria Agents: An Introduction to their Role in Treating Malaria
- 2 Understanding Malaria: A Synopsis of the Disease and its Transmission
- 3 Traditional Malaria Treatments: An Assessment of Limitations and Challenges
- 4 The Mechanism of Action: How do Peptide-Based Malaria Agents Work?
- 5 Evaluating Effectiveness: Clinical Trials and Studies on Peptide-Based Malaria Agents
- 6 Advantages over Traditional Treatments: Exploring Potential Benefits
- 7 Challenges in Developing Peptide-Based Anti-Malaria Agents: Current Roadblocks and Future Perspectives
- 8 Combination Therapies: Enhancing Efficacy through Synergistic Approaches
- 9 Safety Considerations: Assessing the Side Effects and Toxicity of Peptide-Based Malaria Agents
- 10 Pharmacokinetics and Pharmacodynamics: Understanding Drug Absorption and Distribution
- 11 Targeting Different Stages of Malaria: Peptide-Based Agents for Prevention and Treatment
- 12 Future Directions: Emerging Trends in Peptide-Based Anti-Malaria Research
- 13 Exploring Novel Peptide Structures
- 14 Targeting Drug-Resistant Malaria Strains
- 15 The Role of Nanotechnology
- 16 Cost-effectiveness Analysis: Assessing the Economic Impact of Peptide-Based Malaria Agents
- 17 Evaluating Treatment Costs and Outcomes
- 18 Comparative Analysis with Conventional Antimalarial Drugs
- 19 Societal Benefits and Cost Savings
- 20 Regulatory Challenges: Addressing Approval Processes for Peptide-Based Anti-Malaria Agents
- 21 Evidence Generation for Safety and Efficacy
- 22 Collaboration between Researchers and Regulatory Authorities
- 23 Harmonization of Regulatory Standards
- 24 The Promising Role of Peptide-Based Anti-Malaria Agents in Global Health Efforts
- 25 Common Queries and Answers September 2023
- 26 Is ivermectin anti malarial?
- 27 Which is natural antimalarial agent?
- 28 How do antimicrobial peptides work?
- 29 Which is the best medicinal plants for treatment of malaria at global level?
- 30 Which is plant based antimalarial?
- 31 What are the four classes of antimalarial drugs?
- 32 Discover the Power of Peptides: Your Ultimate Resource 2023
- 33 Cite this Article
- 34 Related Posts

domain: chemistry


The EFL has cleared Wolves of any wrongdoing regarding agent Jorge Mendes' role at Wolves.
Wolves faced questions from rival Championship clubs last month while Sky Sports News saw extracts of a letter from Leeds owner Andrea Radrizzani to the EFL and the FA demanding clarification of the working relationship between Wolves and agent Mendes.
After a 'comprehensive review', league officials have determined Mendes holds no official role at the club, owned by Fosun International, and is not deemed as a 'relevant person' and therefore will not be subject to the Owners' and Directors' Test.
Wolves, who secured promotion to the Premier League earlier this month, have maintained they have acted within the guidelines throughout the review, and Wolves managing director Laurie Dalrymple told Sky Sports News he was ready to speak with Premier League officials about Mendes' involvement at Molineux.
Ruben Neves, Diego Jota and Helder Costa are among a number of Mendes' clients to have joined Wolves since Fosun took charge of the club in 2016.
The EFL statement read: "Discussions between the EFL and management of Wolverhampton Wanderers have now concluded in regard to the matter of the relationship between the Club, majority shareholder Fosun and intermediary Jorge Mendes.
"Following the commitment made in March, as a result of some concerns raised by a number of Championship Clubs, the EFL has met with Wolverhampton Wanderers to ensure compliance with the requirements of its regulations.
At that meeting, a request for information was made by the EFL and following a comprehensive review of the detail subsequently provided by the Club, it has been determined that Mr Mendes holds no role at the Club and, as such should not be categorised as a 'Relevant Person' as defined by League regulations. On this basis there is no requirement for him to submit to the Owners' and Directors' Test.
"As part of the discussions the Club has been reminded of its continuing obligation to keep under review the status of both existing Relevant Persons, but also any other individuals who may at some point acquire the status of Relevant Person, and advise the League (and, given the recent promotion, the Premier League) accordingly.
"The EFL would like to place on record its appreciation to the management of Wolverhampton Wanderers for their help and assistance in resolving this matter within a sensible and appropriate timeframe."
Wolves released a statement shortly after the EFL announcement stating they welcomed the EFL's confirmation the club had complied with its regulations.
"After meeting with EFL representatives and providing further written detail, a comprehensive review has concluded with confirmation that the EFL is satisfied there has been no breach of its regulations," read a Wolves statement.
"We have always maintained our clarity on both FA and EFL regulations, which have been complied with explicitly since the change of ownership at the club in July 2016.
"We believe the release of these findings will bring to a conclusion any speculation surrounding the club's operation and extinguish any concerns held by other clubs."


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DAMASCUS, Syria—Syria will redeploy its Lebanon-based troops to Lebanon's Bekaa Valley and from there to the Syrian border, President Bashar Assad said Saturday in a delicately worded speech designed to defuse international pressure for a full and immediate withdrawal.
"Our way is a gradual and organized withdrawal," Assad told Syrian lawmakers in a rare, nationally televised address to parliament as 3,000 demonstrators outside chanted pro-Syrian slogans and held posters denouncing the United States.
The phased pullback was announced with no timetable.
A U.N. resolution calls for the withdrawal of all foreign forces. The Bush administration has called on Syria to remove its 15,000 troops, and additional intelligence agents before Lebanese elections scheduled for May.
"A Syrian withdrawal of all its military and intelligence personnel would help ensure that the Lebanese elections occur as scheduled in the spring, and that they will be free and fair," President Bush said in his weekly radio address.
Bush on Friday said that anything less than a complete withdrawal would be an unacceptable "half-measure."
Syria has maintained troops in Lebanon since 1976. It sent them under an Arab League mandate as peacekeepers during Lebanon's 1975-1990 civil war.
Many Lebanese resent the presence of Syrian troops and agents and Syria's dominion over Lebanese political and economic life.
Assad said that since 2000 Syria had voluntarily removed more than 60 percent of the 40,000 troops once stationed in Lebanon.
He said further troop removals should be negotiated bilaterally with Lebanon under the 1989 Arab-brokered Taif Accords, which ended Lebanon's civil war, and not through international intervention.
While many Syrians expressed relief that Assad's words would turn down the heat on Syria, some opposition figures felt he should have gone further.
"He played a card tonight. But not a strong card," said Suheir Atassi, 32, organizer of an opposition forum that meets monthly in a private home. "Because the United States wanted to hear something specific and not this general discourse."
In Beirut, about 2,000 Lebanese gathered downtown in Martyrs' Square to watch a telecast of the speech. Hundreds waved Lebanese flags.
"Hey y'allah, Syria get out," they shouted, using the Arabic slang for "hurry up."
The square has been a rallying point since the assassination of former Lebanese Prime Minister Rafik Hariri, killed Feb. 14 in a Beirut bomb blast that many Lebanese blame on their government and its Syrian backers.
In his speech, Assad called the assassination a "despicable crime ... targeting Lebanon's unity and stability." He said bringing the culprits to justice "is a necessity" for Syrians and Lebanese alike.
Demonstrators in Beirut jeered whenever Assad alluded to Syrian-Lebanese solidarity and when he said he would withdraw his forces if Lebanon's government demanded it, neglecting to add that the Lebanese government is under Syrian control.
But many protesters said the speech was a victory for their movement, even though Assad sidestepped a timetable for a Syrian pullback and failed to address the fate of Syrian security agents entrenched in Lebanese society.
"If you compare it to his other speeches, it's a step forward," said Lebanese composer Michel Elefteriades, 34, who is Greek Orthodox. "But we were expecting a little but more, because what we ultimately want is a full and immediate withdrawal."
Druze leader Walid Jumblatt who became the de facto leader of Lebanon's anti-Syrian opposition movement upon Hariri's death, told Lebanon's LBC television station in a phone interview from Saudi Arabia: "As a first step, it's a good step as it complies with the Syrian withdrawal according to the Taif Accord."
A key Maronite leader in the opposition, Michel Aoun, disagreed. Speaking on al Arabiya television from Paris where he lives in exile, Aoun described Assad's words as "very carefully studied" but not really responsive to the political reality facing Syria.
"The Syrian army should withdraw to the inside of Syrian territories, not to the border," Aoun said. "I call on the Lebanese to be very careful about the wording and not to be happy over the general meaning."
Elefteriades and the others at the square were young, educated and pro-Western. They believe all of Lebanon is united around their revolution, but the largest segment of their society—Shiite Muslims—is all but absent. Most of Lebanon's Shiites support a Syrian presence in their country as insurance against the dominant Maronite Christians.
(Matza reported from Damascus, Nelson from Beirut.)
(c) 2005, Knight Ridder/Tribune Information Services.
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It isn’t often that you stop breathing for a minute, get revived and then get to meet — and thank — the people who helped save your life. But that happened Monday to Robert Law, 29, of Southeast Washington.
In a ceremony at Engine 25 station on Martin Luther King Jr. Avenue SE, with several of his family members nearby, Law thanked the team of D.C. Fire and EMS personnel who responded to a call for help at his home and saved him on Nov. 9. He credited the rescuers with reviving him after he suffered a severe asthma attack and blacked out.
Doug Buchanan, a spokesman for the D.C. Fire and EMS, said in an email that Law was “actually without a pulse for nearly a minute.” He was face down at a table in his apartment when rescuers arrived.
Law recalled the incident on Tuesday, saying he awoke that morning feeling groggy and bad. He’s had severe asthma since he was a toddler. Even after getting on a breathing machine that day for about 20 minutes, he said, he “couldn’t catch his breath” and asked his sister to call 911.
She did. But before the crews arrived, he passed out, Law recalled. The responding team from D.C. Fire and EMS revived him through CPR and medications, authorities said.
Buchanan said Law went from “technically dead . . . to being alive.”
Law was taken to a hospital where he spent three days.
Of meeting some of those who saved him, on Monday, he said, “That was my chance to thank them and give my gratitude.”
“They went above and beyond,” Law said. “That really touched me.”
Law said he has been seen by his regular doctor and is doing fine following the incident. He was told by his doctor that the incident may have been triggered by being exposed to carbon monoxide. But he said he is not sure how he came into contact with the poisonous gas and has since had his home tested.
He presented some of the rescuers who helped him with a special coin at the ceremony. Doing that, Law said, was an honor.
“It was breathtaking,” he said, of getting to meet some of the rescuers. “I hadn’t seen them since that day. I was just grateful to be alive and talking and walking.”
“They transport people but they don’t always know the outcome of the situation,” Law said. “And I was able to wake up.
“I am grateful and humble.”


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This video shows you how to add transmission fluid to your 2007 Toyota Tundra. Before adding transmission fluid, make sure that your engine was running when you checked the fluid level. If the transmission fluid level on your Tundra is low, you need to add fluid through the dipstick tube. Toyota has been developed sophisticated transmissions through years and it is critical that you add the exact type of transmission fluid stipulated by your owner's manual (typically in the back of the manual in a section titled Fluid Capacities.) When adding transmission fluid to your Tundra, be sure to add it slowly as the transmission fluid capacity is reached quickly and it is difficult to remove excess fluid if you overfill.
If you are having problems with the transmission in your Tundra, such as clunky shifting or hesitation, check the fluid level first - it is amazing how many drivers pay thousands of dollars for transmission work when a half quart of transmission fluid would have fixed the problem.
Coolant hoses wear out over time and need to be replaced - check 'em early and often2008 Toyota Tundra SR5 4.7L V8 Crew Cab Pickup
Did you know that the sun wears out wiper blades faster than rain? Replace your blades twice a year2008 Toyota Tundra SR5 4.7L V8 Crew Cab Pickup
Because you have to start somewhere2008 Toyota Tundra SR5 4.7L V8 Crew Cab Pickup
There's no reason to check the washer fluid level without adding some - see how to do it here!2008 Toyota Tundra SR5 4.7L V8 Crew Cab Pickup
Avoid tickets and accidents with both working headlights! New bulbs are much brighter too2008 Toyota Tundra SR5 4.7L V8 Crew Cab Pickup
If you have an electrical component that doesn't work, try replacing the fuse first2008 Toyota Tundra SR5 4.7L V8 Crew Cab Pickup


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What is Cellulite?
Cellulite occurs when the connective tissue bands pull skin overlaying fatty tissue downwards, causing a dimpling or an “orange peel” effect on the skin. Many factors play a role in cellulite development, but it primarily affects women and is most commonly found on the buttock and thighs. It is estimated that over 90% of women have cellulite and is one of the most frustrating aesthetic concerns to treat.
What Causes Cellulite?
Leading a healthy lifestyle through diet and exercise is an excellent way to achieve overall wellness but doesn’t always keep cellulite at bay. To successfully treat cellulite, you have to have an understanding of its actual cause. Cellulite is not from gaining weight, poor diet, or having an inactive lifestyle.
1. Skin: Over time, skin thins.
2. Fat: Fat cells enlarge and push against the skin.
3. Fibrous bands: The fibrous bands under the skin thicken and cause tension and the signature dimpling on your butt.
What is QWO?
QWO is the first and only FDA-approved injectable for moderate to severe cellulite.
It’s believed that QWO breaks down the buildup of collagen in the fibrous bands. The enzymes in QWO, called collagenase, break down the buildup of collagen in the fibrous bands under the skin, redistribute fat cells, and stimulate new collagen growth.
What To Expect?
You will discuss treatment areas with your aesthetic specialist, and the area of cellulite is marked with a markin pen. A small needle is used to inject the product, QWO. The injections take about 10 to 15 minutes. The entire treatment protocol to acheive the best results is 3 treatments every 21 days. Results may be achieved within 10 weeks, but results vary by patient. Bruising is one down-side of this treatment, however, it resolves quickly and is less evident with the second and third treatment.

domain: medical


By Bijan Razzaghi
The US Air Force has requested as many as 12 F-15Xs worth 1.2 billion in its 2020 budget. The aircraft will be the latest new built F-15s since the 2001 when the US Air Force purchased 10 additional F-15Es. The F-15Xs will be single seat like the existing F-15C and will include several new systems such as the Raytheon AN/APG-82 (V1) AESA the EPAWS electronic warfare suite and the Lockheed Martin Legion IRST sensor. In addition the F-15Cs external hardpoints can employ as many as 22 AIM-120 AMRAAM air to air missiles.
The 12 new aircraft will replace 12 F-15Cs with about 190 more in service. The initial batch will likely test the interoperability between the platform and 5th generation aircraft. The F-15X will be able to function as a force multiplier for the F-22A utilizing 5th generation avionics. The F-15Xs airframe will match that of the F-15C providing the same high performance required for the air superiority mission.
The combination of AESA radar, IRST sensors and a load of 22 air to air missiles the F-15X has a significant edge over current generation threat aircraft such as the Su-30SM and Su-35S. The F-15X boast a larger loadout and longer detection range allowing it to have the first shot first kill on adversary aircraft.
The F-15X will operate alongside the F-35A and F-22A while older generation F-15s and F-16s are phased out in the 2020s. It is possible that the Air Force will decide to procure additional aircraft as the F-15Xs capabilities are integrated into the fleet.
To see access detailed specifications and analysis of all operational military aircraft subscribe to Gladius Modern Military Aircraft Guide.https://www.gladiusds.com/modern-military-aircraft/


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Pentatonix Drop A Cappella Version of Ariana Grande’s ‘Problem’ [VIDEO]
We’ve now got one less, one less problem — there’s finally an a cappella version of Ariana Grande’s ‘Problem,’ and Pentatonix completely smash it!
Robin Williams’ Cause of Death Revealed to Be Asphyxia From Hanging
The Marin County Sheriff’s Department held a press conference today (Aug. 12) to discuss the details, including cause of death, surrounding Robin Williams’ passing.
Robin Williams Dies at Age 63 – Celebrities React
Beloved comedian and actor Robin Williams died this morning (Aug. 11) at age 63, his publicist confirmed.
Nicki Minaj Puts Miley Cyrus in the ‘No Chill Zone’ Following ‘Anaconda’ Spoofs [PHOTOS]
Nicki Minaj may not be responding to Lil Kim’s feud jabs, but she’s definitely striking back at Miley Cyrus and her ‘Anaconda’ spoofs.
Taylor Swift and Selena Gomez Experience Nature on Girls’ Night Out [VIDEO]
Taylor Swift and Selena Gomez received a lesson in nature when the two hung out over the weekend. Pretty appropriate considering it’s the highly anticipated Shark Week!
Jason Derulo Performs Mashup of ‘Wiggle’ and ‘Talk Dirty’ at 2014 Teen Choice Awards [VIDE…
Does Jason Derulo ever give anything less than a stellar live performance? He rocked it out once again with a mashup of 'Wiggle' and 'Talk Dirty' at the 2014 Teen Choice Awards!
Taylor Swift Shows Off Acting Skills in ‘The Giver’ and ‘Ew! It’s Natalie’ Clips [VIDEOS]
Taylor, Rosemary, Natalie — whatever name superstar Taylor Swift is going by, we are so here for it!
Miley Cyrus Goes Camping, Brings Models, Fast Food + Moonshine [PHOTOS]
Miley Cyrus doesn’t go camping — she goes glamping.
Danity Kane Break Up After Physical Fight in the Studio
The Danity Kane reunion was short-lived. The girl group has officially called it quits for a second time, and this one sounds like it’s for good!
Kim Kardashian to Release Book of Selfies
Is there anyone that can take a selfie like Kim Kardashian?
Beyonce Calls On the Run ‘Best Tour of My Life’ Amidst More Divorce Rumors
Beyonce is taking the stance that a photo is worth a thousand words, and all of her words are saying she and Jay Z aren't going anywhere -- except maybe home!
Ariana Grande Adopts New Precious Puppy, Fawkes [PHOTO + VIDEOS]
Taylor Swift has already taken the prize for cutest kitten ever, and now Ariana Grande is coming after the title for cutest puppy ever!

domain: celebrity


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At the end of February I ordered 6 yards of America Jane fabric at Moona Fabrics shop on Etsy (Garden in Green and Tudor Stripe Green). Only 10 days later I had an invitation in my mailbox to go to the post office to get my package. It was one of the happiest days in my life and I all forgot about the rain that day, because the fabric was soooooo beautiful!
Only 6 weeks later I already used the fabric to make some very useful or cute things!
At the beginning of march, a little baby was born and she could use this snuggler ’cause she had a hard time keeping her temperature. A year ago I bought Lotta Jansdotter’s book “Simple sewing for baby” and I always wanted to try out the snuggler-pattern. It turned out to be very useful and the American Jane-fabric did the job! Don’t you think?
Because I liked the fabric so much and I could use a blanket too, I made one for myself using the Garden in Green. I saw these blankets on every weblog I was following and this was the result:
And a few weeks later I finally found a destination for the Tudor Stripes. I made the Reversible Bag, a pattern I found on Very Purple Persons blog, using a Kokka-fabric for the outside, something with orange flowers and the green stripes were perfect as a lining. I also made some matching purses and a pencil case.
Along with these two fabrics I received a small part of the “dots-frabric” from the same collection. I used this fabric to make another pencil case to explain on my own blog how to make an easy pencil case like this. I’m gonna give it away to my readers along with another small purse I made.
And last week, I used the stripes to pimp a shirt and put a dragon on it.
And on the planning, there is a small garden-in-green-circle skirt for the 4 years old girl next door. Though, I didn’t had enough fabric anymore, so I ordered another 7 yards at MoonaFabrics. Hoping it will be here soon, so I can start making the skirt!
Note from Moona Fabrics: Nele, thank you so much for your time, effort, energy and beautiful photography! We truly love the projects you’ve constructed and are honored that you agreed to write a guest post for us. If you are interested in reading more about Nele’s sewing projects and seeing her completed circle skirt, please visit her blog at http://missyn-84.blogspot.com/2011/04/zsazsa-cirkelrok-1.html .
-Nicole & Sue


A new era of BC men’s hockey will begin as Greg Brown coaches his first game behind the bench on Friday. Brown will look to the past to shape how he leads on the Heights.
Fenway Sports Management announces the return of outdoor college hockey at Fenway Park with BC men’s hockey hosting UMass at 6 p.m. on Jan. 7.
Take a look at seven former Boston College men’s hockey players who are bolstering their squads in the NHL.
Boston College men’s hockey announced Friday that Greg Brown will serve as its next head coach following Jerry York’s retirement.
From the time he arrived at BC as a player in 1963 to his retirement after 28 years as the men’s hockey head coach in 2022, Jerry York has left a lasting impact on the BC community.
In 28 years as the head coach at BC, Jerry York produced some of the most memorable moments in college hockey history. Here his top 10.
Jerry York reflected on the off-ice relationships he’s made and the values he prioritizes at his retirement press conference on Tuesday.
After he announced his retirement after 28 years as the head coach of BC men’s hockey, Jerry York addressed the media in a retirement press conference on Tuesday.