Hikvision DS-2CE70DF0T-MF ColorVu 2MP Fixed Turret Camera
High-quality imaging with 2 MP, 1920 × 1080 resolution
24/7 color imaging with F1.0 aperture
Up to 20 m white light distance for bright night imaging
Water and dust resistant (IP67)
The Hikvision DS-2CE70DF0T-MF 2MP ColorVu Fixed Turret Camera is an excellent choice for those seeking high-quality imaging in both day and night conditions. With a 2 MP resolution and 1920 x 1080 pixels, this camera delivers clear and detailed images.


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In Solitaire Tripeaks Farming you will have a good time and enjoy the beautiful nature and the farm full of fruits and vegetables. Play as a farmer and take care of your own farm and overcome the challenges of the game. The games are extremely interesting and constantly changing, making you never bored. Get started now!!!
The gameplay is similar to other classic card games. Your task is to choose the order of cards in a row to win and beat the other levels in Solitaire Tripeaks Farming to reach the new level. Each level is rated from 1 to 3 stars, try to get the highest score of 3 stars. The higher your number of stars goes through the rounds, the more your farm grows

domain: agronomy


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A styled fine art portrait featuring Princess Aria.Read More
What I love most about glamour shoots are the connections we form while shooting. Valerie is a perfect example of that connection. I've had a long-term project that finally took it's first breath with the help of the lovely Valerie. The project included meeting me at Green Mountain well before sunrise in order to hike up the mountain in time for the first light of day which Valerie was totally willing, even coming from Colorado Springs! :)
Valerie was to be my Goddess of Air, the first of my elemental project and not only did she fit the part wonderfully, we've since had another session and plans for more. Here are some highlights of Birth of a Goddess- Air featuring Valerie:
Getting to know models is also a great perk of glamour sessions. Not only can I help bring out whichever side of you that you want to show off, it is a lot of fun! Valerie is no different, she's multifaceted and a sheer joy to work with. :) Here are some highlights from our fun fall shoot, at a location I've been wanting to use for some time now!
See what Valerie had to say about her shoot from her review on my Facebook Fan Page.
Contact me to set up a personalized glamour shoot for your beautiful self!

domain: artistic


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Ms Mengxia Fu
BA, MPS, MA (Hons)
Mengxia Fu is a PhD student in Applied Linguistics at the University of Auckland. She had taught English as a foreign language in China for six years before she received her MA from the University of Auckland in 2014. Her research interests include task-based language teaching, corrective feedback, and the role of individual differences in foreign and second language learning.
Research | Current
PhD thesis: The impact of working memory, declarative memory and procedural memory on the effects of immediate and delayed corrective feedback.
Areas of expertise
second language acquisition, task-based language teaching and learning, corrective feedback, individual differences
Selected publications and creative works (Research Outputs)
- Fu, M., & Li, S. (2017). The cognitive processes of task performance and their associations with working memory. Modern Foreign Languages, 40 (1), 114-124. Related URL.
- Li, S., & Fu, M. (2016). Strategic and unpressured within-task planning and their associations with working memory. Language Teaching Research, 1-24. 10.1177/1362168816684367

domain: psychology


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Goldmine Standard Catalog of American Records 1948-1991
Find Cash in Your Stash
Join the most exciting treasure hunt in America! Now when you discover records in flea markets, thrift stores, second-hand record stores, or your own basement or attic, you can easily find out what they're worth
Inside, you'll find the most comprehensive guide to vinyl anywhere. It includes artists, labels, formats, titles, dates of releases, variations, errors, fakes, cross references, and current prices. Plus, you'll get the Goldmine Condition Grading Guide, a market report, and advice on buying, selling, and collecting: everything you need to know to turn vinyl into gold.
Covers the entire Golden Age of Vinyl (1948-1991)
What people are saying - Write a review
The Collector's Guide to Heavy Metal: The Eighties, Volume 2
No preview available - 2005

domain: library


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Two Mursis walk into a mosque. One comes within reach of the other, but much to the disappointment of the Egyptian president’s lookalike, security guards block the rendezvous. It was seemingly never meant to be.
People greet and take pictures with Egyptian President Mohammed Mursi’s look-alike. (Al Arabiya)
Sohagi, interviewed by Al Arabiya earlier this month, said that people often mistake him for President Mursi, which at times stirs up trouble for him.SHOW MORE

domain: news


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Pair of welded aluminum Argente side tables attributed to Paul Evans for Directional, 1970s. 12" Cube.
Nickel plated steel sculpture by James Prestini, 1955. Signed "Prestini 255."
Campbell's Souper paper dress after Andy Warhol, 1970.
Burl wood and chrome dining table by Paul Evans for Directional, 1970s.
Marble Jumbo coffee table by Gae Aulenti, 1964.


The Nike Swim Women's Essential High Waist Banded Bottom offers the extra coverage you want. Optimal support is provided without sacrificing movement or flexibility. A wide stretch waistband keeps the swim shorts comfortable and secure. The back zip pocket allows for storage of important items when you're on the go.
Main 83% Polyester, 17% Elastane. Lining 100% Polyester.


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Thursday 8th October 7pm
Tickets: Free, booking is required
Rocketman is an epic musical story about Elton John’s breakthrough years. The film follows the fantastical journey of transformation from shy piano prodigy Reginald Dwight into international superstar Elton John. This inspirational story – set to Elton John’s most beloved songs and performed by star Taron Egerton – tells the universally relatable story of how a small-town boy became one of the most iconic figures in pop culture.
Outdoor Cinema in the Rock Garden
This event is open to current EHU Students only
Chairs will be provided and all households / bubbles (up to a maximum of 6) will be seated at least 2m away from all other groups
Pitches will be allocated on a first-come-first-served basis
Please arrive with all members of your party before asking to be seated
As this is an outdoor screening, please come prepared for the weather. Layers / blankets in case it gets cold and waterproof clothing / an umbrella in case of showers.
You are welcome to bring your own refreshments to this event.
In case of extremely bad weather, this screening may be moved indoors. Decisions will be made daily depending on weather, and updates or announcements will be posted on our social media channels.
How to book
- In person at the Box Office
- By phone: 01695 584480
- By email: email@example.com
- Online booking not available


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This is with reference to the editorial “Establish the truth,” (March 29). The framing of Liaquat Ali Shah as a dangerous terrorist failed only because of the conflicting claims between the Delhi police and the Kashmir police. Unfortunately, most sections of the media described him as a Hizb-ul-Mujahideen cadre planning a 26/11-type attack on Delhi. This serious mistake happened because of the media’s excessive dependence on police agencies as an unquestionable and credible news source. Very often, journalists act as stenographers of police agencies by replicating their version of a news story. They should learn to be more sceptical.
The editorial rightly calls for establishing the truth, which should be done without the “breaking news” drama. The terrorist tag attached to a person erodes his or her credibility. Society treats such a person with suspicion.
Terrorists who wish to surrender should be given proper counselling. The government should control cross-border terrorism to put an end to the brainwashing of the innocent. Every effort should be made to delink religion from politics.
S.A. Srinivasa Sarma,
Keywords: Liaquat Ali Shah

domain: sociology


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Memorandum by the Assistant Secretary of State (Berle)
A meeting was held in my office yesterday, consisting of Dr. Feis, Mr. Livesey,23 Mr. Collado,24 Mr. Cumming25 (Eu), and Mr. Roosevelt (A–A). This was called in response to a suggestion from Dr. Feis, to discuss the Netherlands loan.
After a short discussion, it developed:
- All parties were agreed that there was no particular reason for making a loan or commitment to a loan of three hundred million dollars to the Netherlands Government. The Netherlands Government stated that it had a budget deficit; but so do all other governments. The Netherlands Government is not in need of funds, having more than a billion dollars of available assets now. The probable motivation was to induce us to recognize the decree of 1940, which gives to the Netherlands Government the power of disposal of private assets in the United States of persons presently resident in the Netherlands. We are not clear that this is a desirable thing to do. Dr. Feis, modifying an earlier expressed view, stated that in his view also it was undesirable to make such a loan.
- It was agreed that if the Netherlands Government really felt that it needed money we would endeavor to take steps tending to facilitate the transfer of gold here by their Central Bank to the Netherlands Government, so that it could be sold to the United States Treasury for dollars. Note was taken of the fact that the Netherlands Government proably does not wish to do this.
- It is understood that the Secretary feels that the Reconstruction Finance Corporation should take the primary position in this matter.
There was agreement that it would be well if the Secretary could telephone Mr. Jesse Jones, saying, in substance, that the matter was being left with him for decision but that the Department had difficulty in seeing any pressing need for the loan. It was suggested also that the Secretary call to the attention of Mr. Jones the fact that, should this loan go through, we should of once be besieged with applications for other loans from all of the governments-in-exile. [Page 466]Certainly a condition of any loan if granted would have to be heavy restriction on its use for purchasing, else we should have competitive buying in our markets for all sorts of postwar stock piles.

domain: law


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Alien exhibit to reopen in Myrtle Beach this springBy Cassidy Strader • March 27, 2014
An alien encounters exhibit is set to reopen in Myrtle Beach on April 3.
"Encounters: UFO Experience," an exhibit dedicated to the history of UFOs and alien encounters, is set to reopen at Broadway at the Beach on April 3, 2014.
The exhibit, which is said to contain evidence to support claims of alien encounters, features artifacts as well as interactive adventures. Visitors can even experience an alien abduction designed from the accounts of thousands of eyewitness acounts of such events, according to a news release.
Participants can explore evidence about famous UFO events such as Roswell and Area 51, space travel, or pop culture's fascination with the world beyond Earth. The exhibit's artifacts and galleries will be ever-changing, the release said.
"The unique and extraordinary content in our galleries have been provided by UFOlogists from around the world," said Brian Bouquet of The Event Agency. "We plan to keep 'Encounters' dynamic and fresh, so we'll always be looking for more contributions to the story it tells."
Bouquet said Myrtle Beach was chosen to host the exhibit because of the multiple UFO sightings -- 59 reported in 2012 -- along the coast. He said the exhibit is family-friendly and for people with all levels of interest in the topic.
"Whether you're a science fact or a science fiction fan or just curious about intergalactic travel and its implications for the people of Earth, you'll find this exhibition to be immersive, entertaining and very, very memorable," Bouquet said.
Encounters: U.F.O. Experience will be open from 11 a.m. to 8 p.m. Thursdays through Saturdays from April 3 to May 30, 2014. They'll open from 10 a.m. to 10 p.m. Thursdays through Saturdays and 10 a.m. to 9 p.m. Sundays through Wednesdays May 31 through September 2, 2014. Ticket prices are $10 for adults and $8 for children if purchased on their website.
Avista Resort - Save Over 20% and Get Free Unlimited DVD Rentals- Save 20% & Receive FREE Unlimited DVD rentals and free tickets to area attractions.
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Landmark Resort - Winter From $38* Per Night!- Save BIG at this oceanfront resort with indoor lazy river, large indoor pool, hot tubs, on-site dining and more!
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Compass Cove - Oceanfront Rooms from $59- Oceanfront rooms from $69 a night this fall. So grab your bags for a fall beach getaway.
More Details |www.compasscove.com
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domain: travel


From the Sierra Club:
Cooler temperatures bring fallen leaves, and fallen leaves offer the chance to create nutrient-rich soil that will eventually help your spring garden bloom. Instead of cramming raked leaves into plastic bags that end up in landfills, use them to begin a compost pile. Decaying leaves are high in carbon, and will provide your pile’s essential brown material. Need some greens for the nitrogen? Add food waste (apple cores, pumpkin rinds, and so on) begotten from that pick-your-own adventure.


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Tomato-Olive-Pesto Pizza Recipe
Just plain healthy recipe...
Refrigerated pizza crust with pesto, plum tomatoes, olives, red onion and shredded Italian cheese. An incredibly healthy Tomato Olive Pesto Pizza.
1 10-oz. can refrigerated pizza crust
1/3 cup purchased pesto
4 Italian plum tomatoes, thinly sliced
1 2-1/4-ounce can sliced ripe olives, drained
1/4 cup finely chopped red onion
1-1/2 cup light shredded Italian cheese blend
Heat oven to 425-degrees.
Spray cookie sheet with nonstick cooking spray.
Unroll dough; place on sprayed cookie sheet. Starting at center, press out dough with hands to form 13x9-inch rectangle.
Spread pesto evenly over dough. Top with tomatoes, olives, onion, and cheese.
Bake at 425-degrees for 10 to 12 minutes or until crust is a deep golden brown and cheese is melted.
Extra: Basil Parsley Pesto
Fresh basil with parsley and garlic blended into olive oil with Parmesan cheese makes up a healthful and delicious pesto.
1 cup tightly packed fresh basil or cilantro leaves
1 cup tightly packed fresh parsley leaves
1 to 2 garlic cloves
1/2 cup olive oil
1/2 cup grated fat-free Parmesan cheese
1/4 teaspoon salt
Combine all ingredients in a food processor; cover and puree until smooth. Toss with hot cooked pasta or vegetables, spread on French bread or use in any recipe calling for pesto. Can be refrigerated for several weeks or frozen in a tightly covered container. Yield: 3/4 cup.

domain: food


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After 15 successful seasons, “American Idol” has come to an end. Created by Simon Fuller, “Idol” first premiered on June 11, 2002. Ever since, it has become a pop culture phenomenon and formed a lasting legacy.
“American Idol” became the highest-rated television show in the United States for seven consecutive years, and the immense success and popularity of the show caused several spin-offs and competitor shows around the globe, according to TV by the Numbers.
The first half of the finale garnered approximately ten million viewers. At its peak, “Idol” drew up to nearly 40 million viewers. “Idol” officially concluded Thursday, April 7, 2016, and I had the incredible opportunity to attend the finale where the final winner was announced. Fox brought back two of the show’s biggest stars, Kelly Clarkson (via video) and Carrie Underwood in person.
The live broadcast was filmed at The Dolby Theatre in Hollywood. It is the same place where Clarkson, the first winner of “American Idol,” performed her winning solo of “A Moment Like This” in 2002.
Trent Harmon and La’Porsha Renae were the final two contestants on the show’s 15th season and both of their musical abilities were absolutely outstanding. Before the highly anticipated announcement of who won the final title of “American Idol,” every winner and several runner-ups from the past returned to the “Idol” stage to perform one last time.
From Underwood to Jennifer Hudson, the past contestants performed several songs, including a moving tribute to David Bowie. The original “Idol” judges Simon Cowell, Paula Abdul and Randy Jackson even made a group appearance, which prompted a standing ovation from the entire audience.
Season one co-host Brian Dunkleman also appeared alongside Ryan Seacrest, joking that the show had been struggling along for 14 seasons without him. To add to the variety of performances, current judge Keith Urban performed a duet with Underwood. To top it off, an incredibly talented young girl from New Orleans’ Ninth Ward — an area that was hit particularly hard from Hurricane Katrina — performed “What a Wonderful World” with Harry Connick Jr.
Before announcing the final winner of “American Idol,” Seacrest said, “I’ve done this 14 times and the atmosphere has never been more emotionally charged than it is tonight.” Many people in the crowd went wild after Seacrest announced that Harmon had won, but many audience members also were surprised that La’Porsha Renae came in second place.
Overall, however, the entire crowd stood cheering at The Dolby Theatre to celebrate an incredible, unforgettable franchise. Countless fans expressed their sadness over the show’s culmination on social media, many tweeting about their favorite memories in “Idol” history. On Snapchat, there were multiple “American Idol” themed geotags and the event garnered so much attention that it became an official story on the app.
While I was at the finale, a large majority of the audience became teary-eyed. Both past and current performers alike became highly emotional as well. Seacrest gave a quick yet especially heartfelt announcement at the very end of the show, saying, “Thank you and goodnight.”
People all over the world are saying goodbye, not only to the show itself but also to a phenomenon that changed pop culture forever. Although “American Idol” officially wrapped last week, show creator Fuller said in a recent interview with Billboard, “My head is exploding with [new] opportunities. The next generation of Idol — and Idol will certainly be coming back for sure — will have a youthful glow and it will be pioneering again, just as it was when we first began.”

domain: entertainment


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The on-trend distressed look of The Kiba Collection invokes a nostalgic and inviting coziness as inky blacks and sophisticated grays are accented with indulgent ivory and warm beige. Sublimely stylish motifs are approachable and versatile fitting effortlessly into any setting.
|Material:||Polypropylene / Polyester|
|Features:||Easy Care/Fade Resistsant/Stain Resistsant/Pet Friendly|
SCENARIOÂ PRICE PROMISEÂ
If you find this item for less within 30 days, we'll refund you the difference
30-DAY RETURN POLICYÂ
view return policy here
FREE CURBSIDE DELIVERY

domain: design


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ESG category runs for $ 1 trillion
Socially responsible investments that track factors such as environmental, social and governance principles have gained a lot of attention lately, and the category may start to compete with other traditional investments.
IShares Americas director at BlackRock, Armando Senra, has argued that ESG investments could reach $ 1 trillion in assets by 2030, CNBC reports.
The ESG fund category has only just started to gain momentum over the past year, as “we’re only at the very beginning” of what could be a ten-year growth story, said Senra at CNBC.
The ESG category is already on pace with a record year of entries, bringing in over $ 21 billion in the first quarter of 2021 alone. To put that into perspective, ESG funds have attracted over $ 51 billion in sales. ‘net inflows for all of 2020, reported $ 21.4 billion in 2019 and registered around $ 5.4 billion inflows in 2018.
Senra attributed the growing interest in ESG investing to larger asset managers and model portfolio managers who are implementing sustainable investment strategies into their investment models more effectively.
âESG investing has gone from being a satellite or marginal type of investment strategy to a lot more of a core strategy,â Salvatore Bruno, chief investment officer of IndexIQ, told CNBC.
However, as more and more fund managers come up with socially responsible or ESG strategies, it is up to investors to do their due diligence before getting started. For example, IndexIQ’s ESG strategy avoids exposure to Netflix due to energy consumption issues.
âOne of the main reasons they are not part of our strategy is that they have a significant negative impact on the environment due to the high electricity consumption of their data service,â said Bruno, adding that Amazon had not made the reduction due either. to some of its issues with employees which come under the social aspect of ESG.
Todd Rosenbluth, senior director of ETF and mutual fund research at CFRA, warned that while issuers have their favorite ways of defining ESG, the key for investors is knowing what they own.
The same index providers that make the definitions are the ones that ârank growth or value companies,â Rosenbluth told CNBC.
âOften they will agree with each other, but often they will not,â he said. âYou have to understand what’s in the wallet. If you want a commodity closely aligned with the larger market and you are convinced that the five biggest stocks are the same five biggest stocks in the S&P 500, but there are a lot of stocks that aren’t. more declining, so there are some great products, âhe added.
For more news, information and strategy, visit the ESG channel.


200 people wait for iPhone 6 at Lansing Apple store
The new iPhone 6 and iPhone 6 Plus went on sale today and huge lines formed in cities including the Lansing area, where many lined up to buy the larger phones.
Jim Bialik, of Flint, was the first in line at the new Apple store at the Eastwood Towne Center in Lansing Township. Bialik had been in line since Thursday morning.
Close to 200 people - some wrapped in blankets, others dressed in pajamas - were waiting this morning outside the store in anticipation of the iPhone 6. Apple's Eastwood store was slated to open at 8 a.m. - two hours earlier than normal.
Security was assigned specifically for today's release of the iPhone 6 at the store. The growing line was been split into those who preordered their phones and those who hoped they arrived early enough to snag one.
Some of those in line in New York were there in order to quickly buy the new iPhones and then resell them in locations where the latest iPhones aren't yet available, such as China.
At least 400 people were waiting outside the New York City 5th Avenue store to get iPhones Thursday afternoon, and more than 100 were at second store on the Upper West Side. At the latter, the crowd was dominated by people planning to buy the phones to sell to others.
One group was waiting to buy "10 gold iPhones" to resell to a person from Dubai. When a fight b
roke out among another group, said to be from China, the police were called.
Apple won't start selling the new iPhones in other countries for several weeks, leaving such markets as Russia, China, India and Italy out of the loop initially.
hnson, 23, described the scene in New York as "a lot crazier" than when she waited in line for an iPhone 5S last year in San Francisco.
"A lot of people here you can tell are just reselling them," she said outside the Apple Store on the Upper West Side in Manhattan.
Contributing: Eli Blumenthal, SPECIAL FOR USA TODAY, in New York, and Greg Deruiter and Christopher Behnan in Lansing.


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Request a quote
Quality management (QM) in health care is becoming increasingly important - with a focus on patient care.
+49 6151 600-331
Trust is particularly important when it comes to the quality of medical devices. You can establish this confidence in your medical equipment with TÜV PROFiCERT certification under DIN EN ISO 13485.
Throughout the entire production chain: With certification to DIN EN ISO 22000, you deliver proof of quality and safety all the way from the production line to the consumer.
DIN EN 15224 is an internationally applicable quality standard developed specifically for the healthcare sector.
back to TÜV PROFiCERT table of contents

domain: medical


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From Scraps to Sensation: The Magic of Homemade Fish Stock
Fish stock, a time-honored elixir of flavors, has been a staple in cuisines across the globe for centuries. From ancient coastal communities to modern kitchens, this liquid gold has transformed humble fish scraps into a culinary powerhouse. In this article, we will dive deep into the history, popularity, ingredients, nutrition, and serving ideas of fish stock. Prepare to unlock the secrets of this versatile and nutrient-rich broth that will elevate your cooking to new heights.
The roots of fish stock trace back to ancient civilizations, where resourceful cooks discovered the magic hidden within fish scraps. In coastal communities, where fish was abundant, people realized that the discarded bones, heads, and tails of fish could be transformed into a flavorful and nutritious broth. This early form of fish stock became a valuable source of sustenance, providing essential nutrients to communities throughout the ages.
The popularity of fish stock transcends time and borders. Its appeal lies in multiple facets that make it an indispensable ingredient in countless recipes. First and foremost, fish stock offers a sustainable solution by utilizing fish scraps that would otherwise go to waste. In a world striving for greater environmental consciousness, reducing food waste is a significant step towards a more sustainable future.
Moreover, the depth of flavor fish stock imparts to dishes is unparalleled. It adds a savory and umami-rich base to soups, stews, and sauces, elevating their taste profiles. The delicate balance of flavors derived from fish bones, vegetables, and aromatics creates a symphony for the palate. This timeless elixir adds complexity and depth, transforming ordinary dishes into extraordinary culinary experiences.
The beauty of fish stock lies in its simplicity. While the ingredients can vary depending on the recipe and regional preferences, there are a few key components that remain constant. Fish scraps, such as bones, heads, and tails, form the foundation of the stock. This is complemented by aromatic vegetables like onions, carrots, and celery, which add depth and fragrance. Aromatics such as garlic, bay leaves, and parsley lend their magic to the mix. Water or broth provides the liquid base, while a splash of white wine or other acidic liquid balances the flavors.
- 1/2 onion chopped
- 1 carrot chopped
- 1 stalk celery chopped
- 1 1/2 pounds fish trimmings or shrimp shells
- 1 bay leaf
- 4 cups water
- 1 cup white wine
- Twist of lemon
- Salt and pepper
- In a large saucepan, combine the chopped onion, carrot, celery, fish trimmings or shrimp shells, bay leaf, water, white wine, twist of lemon, salt, and pepper.
- Slowly bring the mixture to a boil.
- Reduce the heat, partially cover the saucepan, and let it simmer for 1 to 1 1/2 hours, allowing the flavors to develop.
- Strain the stock through a fine sieve or a cheesecloth-lined colander to remove any solids.
- Press or squeeze the vegetables and fish to extract all the liquid, ensuring maximum flavor. Discard the solids.
- Use the fish stock immediately in your desired recipes, or freeze it for later use.
Beyond its culinary prowess, fish stock offers a myriad of nutritional benefits. It serves as a valuable source of protein, which is essential for muscle repair and growth. Additionally, fish stock contains important minerals like calcium, magnesium, and potassium, which contribute to overall well-being. Perhaps most notably, fish stock is rich in collagen, a protein renowned for its role in supporting skin, hair, and nail health. Sipping on fish stock not only nourishes the body but also promotes a radiant appearance.
Fish stock is a versatile ingredient that can be used in a multitude of dishes. Let’s explore a few serving ideas to inspire your culinary adventures:
- Seafood Chowder: Harness the essence of the ocean by using fish stock as the base for a hearty seafood chowder. Combine it with succulent shrimp, clams, potatoes, and corn for a bowl of comfort and indulgence.
- Bouillabaisse: Transport yourself to the coastal shores of Provence with a classic French fish stew. Infused with fish stock, tomatoes, saffron, and an array of seafood like shrimp, mussels, and white fish, bouillabaisse is a celebration of flavors and textures.
- Fish Soup: Keep it simple yet satisfying with a soul-soothing fish soup. Combine fish stock with freshly chopped vegetables, such as carrots and celery, and chunks of white fish for a light and nourishing meal.
- Seafood Risotto: Elevate your risotto game by substituting chicken or vegetable broth with fish stock. The delicate flavors of shrimp, scallops, and white fish mingle with creamy Arborio rice, creating a luxurious and unforgettable dining experience.
Fish stock is a culinary treasure that continues to captivate chefs and home cooks alike. Its rich history, unmatched flavor, and nutritional benefits make it a must-have ingredient in your kitchen. By embracing fish stock, not only are you reducing waste and embracing sustainability, but you are also unlocking the potential for creating extraordinary dishes. So, the next time you have fish on your menu, don’t discard the scraps; instead, transform them into a delicious and nutritious fish stock that will elevate your cooking to new heights. Embrace this timeless elixir, and let its enchantment flow through your culinary creations.


The Connecticut Department of Consumer Protection’s (DCP) October 2015 press release warns consumers and resellers to immediately disable “Lane” and “Virginia Maid” brand cedar chests with lids. The warning came in the wake of the 2014 deaths of a brother and sister who suffocated in a chest after the lid closed and automatically latched shut.
The Lane Furniture Company, in cooperation with the U.S. Consumer Product Safety Commission (CPSC), initially recalled 12 million chests in 1996, with subsequent recalls in 2000 and 2014. To avoid further tragedies, DCP and CPSC conducted over 50 compliance checks at second hand stores and educated businesses on how to identify the recalled items before consumers purchase them.
Lane recalled 12 million chests since 1996 with latches that automatically lock with the lid is closed, the article states. The company continues to offer new latches for these chests without charge. Despite past recalls, press releases, and replacement offers, approximately six million locks still need replacements according to Lane’s product safety webpage.
More information can be found on the Department of Consumer Protection’s website.


Boys are naturally more athletic than girls. They are built bigger, they are physically stronger, right? While this may be generally true, the importance we, as a society, place on men’s physicality should be debunked. Women, pertaining to athletics, are considered less than men in athletics. The amount of time I heard “I can’t watch girls playing soccer. It’s so boring,” in my life as a soccer player is asinine. I accepted it then, nodded and even agreed. (Hey, I was young and too busy impressing boys to question what people said.) This is a societal norm we grow up with, and we always think norms are true until we realize they’re not. Some people may still believe this, but the issue that has been getting more attention over the past few years is trying to debunk those disbelievers. Should girls be allowed to play on boy sport’s teams? If so, what ages are appropriate for co-ed teams?
My female cousin, Tina, played little league football for our township growing up. She is a football fanatic to this day, and she played because she wanted to. Two years later, she stopped playing, but not because she didn’t enjoy it. Rather, she saw that she would never be taken seriously on the field, because she played football like a girl.
This led me to look at sports at Rowan, and I found something that struck my interest. Dana D’Angelo, 23, played on the Rowan Women’s Ice Hockey team her last two years of school. This team was recently formed in the last three years. I’d never heard of a women’s ice hockey team, so I was curious. Generally, ice hockey is thought of as a tough macho-man sport, because it is tough, and it is one of, if not the only sport, (I know of at least) that allows physical altercations. My family is full of huge Flyer’s fans, and I’ve often heard that hockey is the toughest sport. (Obviously people may agree or disagree. I don’t really think about it enough to put my opinion out there.)
(Dana D’Angelo, above, sent me this photo after the interview.)
I was curious about how she felt playing a sport that is considered tough (for men, which is basically twice as tough for women, you know?), and although it was not a co-ed team, it is still considered a masculine activity.
She was eager to answer my questions, and I am just as eager to share them with you.
(Dana, to the left, sent me this photo.)
Q: When was the Rowan’s Women’s Ice Hockey team founded? I’ve never heard of it before.
A: “My junior year my teammates Laura and Rachael, who have been playing ice hockey for awhile decided to start the women’s team. They started recruiting other girls and then there was 10. Some who played in the past and some who have never held a stick or were [never] on the ice besides falling down on it.”
Q: What were the responses of family and friends when you started playing?
A: “The type of responses that I received when I told people I was playing were very supportive. I came from playing roller derby which was rough and hard and looked at as ‘a lesbian sport,’ even though it was mostly married women with kids and just me. So I was used to being looked at as playing a rough and crazy sport.”
Q: What were the games like? Generally speaking, what was the energy like at the games?
A: “It was awesome to have friends come out and watch the games, and see how tough us women can be out on the ice, and that it’s not just intertwining when we play.”
Q: What do you mean by that last part? Can you expand on that a little bit?
A: “Of course. I mean, we had a team full of girls who could kill it on the ice and then go out in a dress to a bar after if we wanted, and kill it at the bar.”
Q: Being a male dominated sport, did you ever feel like you were being judged by anyone?
A: “I didn’t feel like I was being judged by anyone, but if they were I probably just didn’t even care to notice. After taking the big step to come out in high school, I never cared about what people thought of me. I just wanted to do what made me happy.”
(Dana sent me these photos after the interview. She is to the far right. They won the championship her senior year.)
Girls are just as “tough” as boys both physically and mentally. As for co-ed teams, I think they are necessary for youths, but I am not sure where I fall in the spectrum after a certain age. I think it’s important to note that just because men are thought of as tougher than females, we can be just as tough. The creating of this hockey team goes to show that gender norms are shifting, and people aren’t as likely to fall into one category or the other, but they can allow themselves to be anything they want to be, female or male. Down with gender norms!
Until next time!


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In February, the Law School hosted the first African-American Law Alumni Reunion. The weekend marked the 60th Anniversary of the first black graduate of William & Mary, Edward Travis, ’54. The weekend drew over 70 alumni and guests and included a program of speakers and panels, as well as an opportunity to network with current W&M Law students. The annual BLSA Oliver Hill Dinner was also held during the weekend. For a pictorial recap of the weekend, please visit the celebration website.
The Black Law School Association was named the 2014 Mid-Atlantic BLSA Chapter of the Year. Congratulations to the 2013-14 officers and members.
The American Bar Association’s Commission on Sexual Orientation and Gender Identity recently singled out 9 law schools for taking extra steps to be more inclusive of LGBT students by establishing associations or forums designed to enhance educational opportunities for these students. William & Mary Law School was one of the 9 law schools singled out by the ABA for special praise.


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I have just figured out something in my life, that many of you who are also dealing with a dementia issue may have already known. That is, the stress of dealing with the reaction of others, to my disease, is causing me great difficulties. I honestly just figured this out in the last few moments. And, honestly, I don't know what to do with it or about it. I see a number of reactions to my condition, especially since it is becoming more apparent to everyone, that I am progressing more and more. I see anger, disbelief, disapproval, sympathy, sadness, horror, and even shock. One day, not to very long ago, we were in a restaurant, and as is now the process, Linda was ordering for me. The waitress was very disapproving of this arrangement. I guess she did not know what was going on, but she was really shocked. Some people talk louder to me. I guess they think I can't hear them or maybe I forgot HOW to hear! Trust me, I can't remember but I hear fairly well in my left ear. My right ear is of little use because of the MK 42 5"/54 Naval Gun.
However, I am writing this to ask for some input from those of you who read this Blog and are dealing with the same issues. Am I being over sensitive? Or do you see the same things also. I will also ask the EASE support group people also.
Thanks for your help.


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Nature on call to deep rip soils
Come spring, a small group of WA growers’ paddocks will be awash with a different shade of gold as they swap deep ripping for trials of a biological option — safflower.
While they may be a sight to behold in bloom, it is what is happening beneath the surface that is drawing attention.
The plant’s deep-penetrating roots can extend to depths of more than 2m, opening up the soil and breaking up the clay, preparing for the next year’s wheat crops.
It has attracted a small number of growers battling rocky, tight and salty soils as a way to bypass deep ripping, but still enabling crops to penetrate soil faster and absorb more moisture and nutrients, with the hope of yield improvements. It has so far delivered varying results.
There are several varieties available, split into two categories — linoleic oil and oleic oil — with WA growers trialling a linoleic variety.
Ravensthorpe grain growers Pete and Lena Daw — who crop 2700ha of wheat, barley, canola and peas on heavy, high pH soil — trialled 50ha of the plant last year.
“Everyone’s getting a response from deep ripping and we have a lot of rock here,” Mr Daw said.
“I didn’t want to go dragging rock out and picking rock again, so we looked into safflower.
“We have saffron thistle, which is a very similar plant as a weed. We saw it in Victoria years ago and didn’t think much more of it and then we did a bit of digging, and it gets down to about 2m deep with it’s roots.
“I don’t know whether it will work or not, but we’re trying to see if it will bypass the deep ripping — doing it biologically, (which is) better than diesel.”
Mr Daw said they would not know the impact of the crop until this year’s harvest, but he planned to plant another 70ha this winter.
Esperance grower Brad Campbell first planted 9ha in 2018.
“We’ve got tight, sodic soils here, so it was a way of trying to increase rooting depths without deep ripping,” he said.
“You can’t bring sodic clays to the surface — we have that small percentage of WA soils that are extremely detrimental to deep rip ... there’s too much sodium and boron salt.”
In 2019, he planted 400ha, but dropped back to 32ha last year as he had been unable to shift all of 2019’s harvest, with about a third still sitting in silos.
The small domestic market for the product, which is predominantly sold as bird seed, has been one of the challenges growers face.
While he said he got “excellent return” for what he had sold, Mr Campbell was unsure whether he would plant it again this winter.
“The market is just so small,” he said. “There’s more options over east, but it’s a very light seed so transportation is a bit expensive. However, a “super high oleic” variety developed by GRDC and CSIRO produces oil used in machinery lubricants.
Trials are set for the Wheatbelt next month, with hopes it could be grown commercially next year.
A lack of spring rain, coupled with the safflower’s water-use also impacted yields.
“Our wheat growing on safflower stubble looked really good, it was looking excellent, but it ran out of moisture in spring,” Mr Campbell said.
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Welcomes Food Day, HIMATEPA UNUD degreed The Oration
Student Association of Food Science and Technology Udayana University held a speech activities to commemorate World Food Day coincides with the day which falls on October 16. The event, held since 7 o'clock this morning quite successful. Activities carried out in Catur Muka Puputan is attended by visitors crowded field blowing at the time, considering the event was held on Sunday, when many people pay a field visit just to relax or exercise. People who are not directly join in the event quite enthusiastic about witnessing this event.
The theme of this oration activities is "CLIMATE CHANGE, ALSO FOOD AND AGRICULTURE IS A MUST ". Not only do the speeches, the event begins with the socialization of World Food Day to the people in the environment around the field blowing directly conducted by coating the handing out brochures about the local food and local food products such pia purple yam. Then the event was continued with activities to share impressions and messages socializing moments of World Food Day. Then last event oration carried out activities initiated by representative BEM PM Udayana who was represented by the President of BEM which I Wayan Artadana who express their aspirations in commemoration of World Food Day. Then this oration continued by representatives BEM FTP. Not only them, some organizers are also participants participated in expressing their aspirations will be the World Food Day in a speech. (arisugama)


Much has been made this college basketball season about BYU’s depth.
There are several stats that illustrate that depth, but this one might be the most telling — during the last eight games, the Cougars have been led in scoring by seven different players.
The most recent was sophomore Trevin Knell, who scored 15 points in BYU’s regular-season finale against Saint Mary’s.
Before that it was Alex Barcello (29 vs. San Francisco), Matt Haarms (21 vs. Loyola Marymount), Caleb Lohner (19 vs. Pacific), Gideon George (19 vs. Portland), Brandon Averette (24 vs. Pacific) and Spencer Johnson (15 vs. Pepperdine).
Seven leading scorers in eight games? That the kind of stat coach Mark Pope loves.
“It’s special for us because we’ve built this team on guys sacrificing for each other and trying to make plays for each other. You think about the confidence in our locker room that each guy has for each other. It’s really spectacular,” he said. “These guys look around the locker room and they’re like, ‘Hey, I know he can help me and he can help me and he can make big plays.’ We’re really blessed.
“You don’t have this team all the time. Seven out of eight? I’m 100% sure nobody in the country has done that,” the BYU coach continued. “It’s a fun statistic to talk about but it’s really exciting when you think about the trust that is floating around our locker room right now in terms of believing that guys can help you.”
Strong performances from players both off the bench and in the starting lineup have helped BYU post a 19-5 record this season and earn a No. 2 seed in the West Coast Conference Tournament. The Cougars received a double bye all the way to Monday’s semifinals.
Owning this kind of depth could bode well for BYU as it enters the postseason. The Cougars have received key contributions up and down the roster all season long. For example, Knell has made 15 of 25 3-pointers during his last six games.
“He’s learning and he’s got a chance to be a real special player,” Pope said of Knell. “There’s not a lot of players shooting (like that) from 3 in their last seven games.”
Barcello pointed out that Knell is contributing in more ways than just knocking down 3-pointers. Knell was a big factor in the win over Saint Mary’s beyond his shooting from distance.
“He had a huge impact. He came in and grabbed some really tough rebounds. He was super physical on the defensive end,” Barcello said. “He hit some really, really key shots. That’s what Trevin does. He’s a great shooter; a phenomenal shooter. I was so happy for him. Everyone on our bench was having fun. They were so happy for him when he banged a couple of 3s.”
George has been playing well in February as well. Against the Gaels, he scored 11 points, including 3 of 4 from 3-point range, and grabbed four rebounds.
“Gideon’s emergence has been really great for us. He’s a really important piece. He’s a guy that won’t be told no,” Haarms said. “He won’t take what the defense gives him, he just takes what he wants. Sometimes when Gideon does something, I’m like, ‘Oh no.’ Then I’m like, ‘Wait, that actually worked.’ He won’t let anyone dictate what he does. That’s so awesome to have a player like that. He will go and get a basket when you need it.”
Averette likes playing on a team where any given player can go off on any given night.
“It’s fun. If the same guy is leading the team in scoring every single game, that doesn’t feel good to a role player, who may not have as big of a role,” he said. “I feel like us being able to have anybody that can lead us in scoring just gives us confidence as a team. Everybody’s out there playing confident and trusting the work they put in every day.”
BYU’s depth could be a good recipe for postseason success.
“It’s so nice to see every single guy on this team and how they’ve grown over the year,” Averette said. “It’s great timing heading into March. We want to be playing our best basketball. As you’ve seen throughout the season, we have so many weapons. It’s going to be fun.”


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For quite a few engagement ring customers, the most popular diamond color is white – certainly, the whiter, the superior (and the pricier!). A pure white diamond, often recognized as blue-white and graded colour ‘D’ is extremely tough to occur by and these stones need quality charges. As you transfer down the diamond colour scale (and down the alphabet towards a grading of ‘Z’) the diamond will become much less white and tends toward pale yellow colors. These ‘tinted’ diamonds are deemed to be of an inferior colour and consequently fetch lessen costs.
At a stage nonetheless, the yellow coloration in a diamond is so vivid and so powerful that it crosses out of the regular diamond color chart and is thought of a ‘fancy’ coloured diamond. Extravagant coloured diamonds are exceptionally scarce and exceptionally precious, commanding prices of 10’s and 100’s of 1000’s of dollars. But what causes colored diamonds? Why are some white and some not-so-white and some blue or pink or brown or purple?
Really merely, the shade in diamonds is brought on by chemical impurities or deformation of the diamond crystal composition. Ironic, when you consider that on the A-Z diamond colour scale, significantly less pure usually means significantly less value!
Let’s start with white diamonds. Diamond is comprised pretty much entirely of the ingredient Carbon and a pure blue-white diamond (graded coloration ‘D’) will contain no chemical impurities – it is a pure sort of Carbon. On the other hand, the place of the earth the place diamonds develop is essentially a chemical scorching-pot, with lots of other features waiting to be snapped up by minerals as they develop. 1 of the more prevalent aspects is Nitrogen and, when a diamond has a considerable total of Nitrogen in its composition, the diamond will take on a yellow colour. The additional nitrogen in the structure, the much more yellow the diamond.
The existence of nitrogen can also impart an orange colour, but orange diamonds are extremely unusual. Violet coloured diamonds are also pretty scarce and are considered to be prompted by the presence of hydrogen in the diamond framework.
Blue diamonds are amongst the most prized colors and 對戒 are identified in only a minimal selection of locations around the globe. Blue diamonds are prompted when the ingredient Boron is incorporated during the expansion of a diamond. As is the scenario with Nitrogen and yellow diamonds, the far more Boron there is in a diamond, the darker the blue colour will be.
Black diamonds are the outcome of a large selection of imperfections and inclusions (frequently graphite inclusions) inside a diamond. There are so quite a few inclusions that the diamond is practically opaque and makes it possible for just about no light to go as a result of, resulting in a black overall look. Black diamonds can practically be deemed as industrial diamonds and are thus traditionally priced reduced than white diamonds. The diploma of imperfections can make black diamonds extremely difficult to lower and you will frequently only locate black diamonds slash into round good styles.
Brown diamonds and pink diamonds are assumed to be the final result of the same procedure – crystal deformation. Diamonds, like other crystals, have a frequent arrangement of atoms and bonds, but underneath stress, these atoms and bonds can shift out of placement and it is this change that results in a colour transform to possibly brown or pink, quite possibly relying on the diploma of change. This method is also thought to account for red and purple diamonds that are occasionally uncovered.
Inexperienced diamonds are extremely unusual and are the result of a diamond possessing been subjected to radiation, commonly deep within just the earth’s crust or mantle, hundreds of thousands of a long time in the past. Really don’t stress while, if you have a environmentally friendly diamond, it’s not radioactive!
An vital actuality to bear in thoughts when obtaining colored diamonds is to request the retailer or diamond supplier no matter if the diamond colour is all-natural or improved. Several laboratory tactics can be made use of impart, boost or alter the organic color of diamonds and this sort of information and facts must be provided to the diamond purchaser.

domain: chemistry


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NEW YORK (AP) — Stronger earnings from several U.S. companies are sending stock prices higher in early trading.
Video game maker Electronic arts rose 6 percent and LendingClub rose 5 percent early Wednesday after reporting results that beat analysts' expectations.
Energy companies rose far more than the rest of the market as the price of crude oil continued its climb above $60 a barrel.
The Standard & Poor's 500 index rose two points, or 0.1 percent, to 2,092 as of 9:35 a.m. Eastern time.
The Dow Jones industrial average rose 34 points, or 0.2 percent, to 17,960. The Nasdaq composite gained six points, or 0.1 percent, to 4,946.
The price of oil rose $1.42 to $61.82 a barrel.
Bond prices fell. The yield on the 10-year Treasury note rose to 2.20 percent.


|Diran Odeyemi||Thursday, October 2, 2003|
ANNOUNCE THIS ARTICLE TO YOUR FRIENDS
LADOJA VS. ADEDIBU: LET THERE BE PEACE IN OYO STATE
oing down memory lane, I still remember how in my secondary school days I used to invoke the 'devil's spirit' to ignite physical combat whenever two students had cause to argue. There were special renditions composed by some of us that were nicknamed "Apero Ija" (fight promoters) that would lure and encourage students to exchange blows. Our duty in which we were experts of sort was to persuade and convince two students to fight where there was not enough courage by either of the two to take up the challenge for a brawl.
While it was fun then, promoting fight and supervising combat, maturity has crept in now and I no longer see anything entertaining in two or more people calling for war. I want to enjoy the Biblical bliss of a peacemaker and have been an apostle of peace wherever there is uproar.
Perhaps it would be fun seeing political giants slugging it out physically, I mean Alhaji Adedibu grappling Senator Ladoja by the throat, and the governor fighting back to wrestle Adedibu to the floor while we stand by as judges to determine who is powerful and who is not. This however is an unlikely situation, what is possible and usually the tradition is leaving the supporters of Adedibu to do the real battle with the followers of Senator Ladoja using sword as weapon while the actors themselves watch from safe distance only trading in words while savoring "Amala with Gbegiri".
Who suffers in the fight of two elephants is the grass and trees around the venue, and of course in this case it is the foot soldiers. A distraction is enough to make a government lose focus and when there is absence of peace in Oyo State, there exists a dangerous signal for Yorubaland and most especially for the entire PDP, the ruling government.
These were my exact words on this page; "As it was in the beginning, so it is now, many elected governors have their own "Ubas" while many Ubas also have their own stubborn "Ngiges". Like a circle, it goes round and it will come round, this is just a rehearsal of some disasters lurking in the corner… let us watch out for more free video show".
I continued: "In some States, the seemly silence of a graveyard is made possible because some governors have conformed to pre-election agreements; they have fulfilled the first leg of their vow…those governors who appear doggy will soon realise that they are seating on a keg of gun power. If it has not exploded like it went off in Anambra is never an indication that it will never detonate".
Now that Alhaji Lamidi Adedibu has declared war on his political son, Senator Rasheed Ladoja, it is logical to conclude that this is round two of a thirty-six bout encompassing "family affair" tackle that we the spectators will watch between now and 2007.
Senator Ladoja is a governor that has a unique style of doing things. I was in Ibadan in the early days of his administration and find it difficult to place him. He appears quiet but wears the look of a determined soul, taking time to plan a strategy. Unfortunately nobody could predict or say categorically if such strength of mind would be to avenge some past misdeeds or be directed towards achieving certain social and economic gains for the people of Oyo State.
He has taken a plunge to change the old order or so his action portrayed, which to him may be necessary to move forward but if I were to advise him, he needed to be more tactical and would not have rocked the boat of which he is the captain in control. It may be too early to know what is the cause of disagreement between the governor and Alhaji Adedibu but it sure has no semblance to what happened in Anambra State, I am confident that the personalities involved are too sophisticated for such absurdity.
Alhaji Adedibu's brand of godfatherism has a grade that belongs to another category, which is a direct opposite of Ngige's illiterate approach. For all I know, Adedibu seldom finances aspirants and in Ladoja's case, he is a big fish that came to swim in PDP's pond, which in a way ruled out the possibility of having to pay back in cash. Assuming that the demand to pay back is requested in kind, I do not think it should be a problem if gratuitous patronage is done within the confines of law and perceived in public good.
Alhaji Adedibu as far as I can say is a politician who loves to put his political energies to election so as to be able to put his mouth (not his sons and daughters) in such government. He represents the middleman between the governed and the government and like Oloye Saraki in Kwara, he holds the ace in Oyo State. As a grassroots but a practical politician that operates open door policy, with a nod of the head and snap of his finger he has installed many governors apart from being instrumental to the realization of other people's ambition.
It sure would be dangerous to challenge such a political strategist without a clear-cut explanation made known to the public who are very much aware that it was on the back of this same "tiger" that many people rode to office.
As we await the elders' efforts in this crisis, let all "Apero ija" beating the drum of catastrophe know that they will not be speared when the real "roforofo" fight begins. To the warriors, no good fighter ever emerges victorious without a bruise that will leave a scar as an everlasting reminder that once upon a time, a war had been fought. I do not see Governor Ladoja winning neither would Adedibu come out of it without a bruise. This is why the two of them should think twice, it better to give peace a chance.


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Who we help
Worldwide Friends of Ugandan Orphans supports children in the cities of Mityana, Kangulumira, Lewero, and (previously) Golomolo, each about 40 miles from Uganda's capital, Kampala.
Located 40 miles East of Kampala, the Mityana orphanage is home to about 100 children, each of whom has lost one or both parents and relies entirely on the orphanage for all living necessities. The sincerity and self-sacrifice of the orphanage director originally drew us to this orphanage in 2005. With very limited resources, the director took in children with extreme need and often gave up his own income to support the children. Thankfully, for almost 17 years, we have been able to visit and send aid to the Mityana orphanage, helping provide everything from a healthy diet to, most recently, a new school (click here to read more about what we do).
Neighboring the orphanage is Trio Primary School, the main source of education for the children. This school, pictured at left, is now renewed, thanks to your generosity.
Enter our current and biggest project to-date: constructing a new clinic! This project will cost $40,000 and result in a clinic to help treat the orphans and all the people in need. Please help us complete this mission! To learn more, visit our blog and read about what we do. Click here to donate.
Clothing & shoes distribution (Kangulumira)
In Kangulumira, a town 40 miles northwest of Kampala, we support a more scattered group of orphans, most of whom congregate at a local Church and nearby school. We provide living necessities to all, including clothing and a healthy diet, and various other means of support to improve the life of each child. For example, one group of boys has a special interest in soccer, and through the generosity of donors in the United States we were able to provide them this year with jerseys, soccer balls, cleats, shin guards and athletic socks (see image at right).
As in Mityana, the children in Kangulumira are inspiring for their proactiveness, optimism, and persistence. They genuinely seek every opportunity to improve their situation, including attending school and, later, finding a job. We are able to pay the school fees for five children, who currently range in age from 5 to 15. We have been helping a couple of the oldest orphans now for almost ten years. Having funded their education, we subsequently helped them find means to make a living, including through farming, teaching, or in one case, opening a hair salon.
We have also developed a mutually-supportive relationship with the director of the local school, who supports our work and has helped us establish good relationships with local merchants.


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I thought a fun way to spend some time would be to visit the oldest house in Manhattan.
The Morris-Jumel Mansion was built in 1765 by a British colonel. The home was confiscated during the Revolutionary War, and George Washington used it as a crash pad.
In 1790, he threw a dinner party, where he entertained Thomas Jefferson and others in the Octagon Room.
This was Washington’s bedroom and study.
The home was later sold to a French wine importer named Stephen Jumel. After his death, his ex married Alexander Hamilton’s murderer, Aaron Burr.
This is one of the Madame’s bedrooms.
After the wonderful visit inside, and a stroll though the property's garden, I walked up High Bridge Park to see, both, the park's namesake, which is the 2nd oldest pedestrian bridge in Manhattan (first built in 1860, and finished in 1883), and the High Bridge Water Tower, which was built in 1872.

domain: geography


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The two sides came together in Thailand on Tuesday afternoon with Erik ten Hag and Jurgen Klopp putting their respective players through their paces for the first time ahead of the 2022/23 campaign. United were emphatic winners as they racked up a comprehensive 4-0 victor y.
Jadon Sancho gave them a perfect start, with Fred and Anthony Martial both also getting on the scoresheet before the interval. Young forward Facundo Pellestri then got in on the act to round off a thoroughly satisfying afternoon.
Whilst he was delighted to have made his debut for the Reds, he signalled his frustration at what was a disappointing result. “We have a winning mentality that starts in training and we want to win at any cost. Today is bittersweet for me as it’s not nice to get beat, especially in the way we did against United,” he said to LFC TV.
“We’ll make sure we correct our mistakes and put it right in the next game. Next game I’m sure I’ll score, that’s the mentality you’ve got to have!”
How much of a role with Fabio Carvalho play for Liverpool this season? Share your thoughts in the comments below
Carvalho has only been a Liverpool player for a matter of weeks but has already drawn praise from Reds boss Klopp with his versatility having been noticed. The youngster also hailed his new teammates for the way they have welcomed him to Merseyside.
“Everyone has been fantastic to me which I’m so grateful for. It sounds cliché but it feels like one big family,” he continued.
Carvalho was not the only debutant for the Reds in the clash with Man Utd in Bangkok. Potential record signing Darwin Nunez also made a second-half appearance for the side despite having picked up a niggle ahead of the game.
In the meantime, Tyrell Malacia was also handed his bow for United having previously completed a switch from Feyenoord earlier this month. The Dutchman was of course delighted at his first outing for the Red Devils and the result.
Speaking to MUTV, he said: “I’m very happy. It feels amazing to be here, to wear this shirt and play with these people. It was difficult because of the weather, it’s very hot, but we made it.”
Liverpool are now set to travel to Singapore to continue their pre-season schedule against Crystal Palace. Elsewhere, Man Utd fly to Australia for a clash with A-League outfit Melbourne Victory.


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On-Call Ethics Consultants in Human-Subject Research
May 4, 2015
Framing the Issue: Private Consultants and IRBs
There are some ethical issues that fall outside the purview of an Institutional Review Board (IRB). In October 2014, a Nature article described an example of clinical trial investigators who discovered incriminating information about a pregnant teenage girl and her boyfriend while interviewing them for a trial that looks at teen pregnancy. The two had lied to each other about their ages, but told the investigators the truth. The girl was fifteen and her boyfriend, who was willing to participate in the trial and be a part of the baby’s life, was twenty-four. The investigators called a private ethics consultant for advice. The consultant was a pediatrician who also ran an ethics consultation service. He explained their legal obligations and told the researchers that they “have to report it.” The police investigated the situation. The researchers never heard from the girl or her boyfriend again.
The private consultant was called in because the researchers found themselves in an ethically gray area where all of their options led to problematic outcomes. If they report the couple, then the father may not be involved in the baby’s life, and if they do not report the couple, then they are allowing an illegal act to go unpunished and may be held accountable.
This story sets the stage for a discussion on whether there is a need for private ethics consultants in human-subject research even though research with human subjects must be approved by an IRB. The IRB provides ethical oversight. Its job is to ensure that the research is being conducted in a manner that is in compliance with human-subject research standards. Those standards ensure that the research subject is protected from abuses or harms.
According to the Nature article, advocates of private consultants believe that the advantage is that, unlike IRBs, the consultants can offer non-binding counsel, and are able to discuss a wider range of issues than would be necessary for the regulatory process. Furthermore, the article says that ethics consultants can offer “more creative solutions” than an IRB, as well as provide guidance throughout the study “in a non-confrontational advice-giving capacity.” And, as Marion Danis, chief of the bioethics consultation service at the NIH Clinical Center, points out, they offer “an open space for talking about research ethics in a way that is not driven by the regulatory environment.”
Critics question why there is a need for a separate body from the IRB, and suggest that the bioethicists who serve as consultants be folded into the IRB regulatory structure. Incorporating the bioethicists would ensure that all problems are addressed by the very IRBs that researchers must go through for approval. Those who believe ethics consultants could be a helpful third party counter that consultants serve to complement IRBs, not become a part of them.
The Stanford Model: A Consulting Group in Practice
A 2008 article in the American Journal of Bioethics, co-authored by Mildred Cho who is quoted in the Nature article mentioned above, makes a case for a collaborative research ethics consultancy and describes their experience with implementing such services. Cho is the associate director of the Stanford Center for Biomedical Ethics that uses a team-based approach for ethics consultation services. The aim of their model is to “make ethics advice available to biomedical researchers as the science unfolds.” They believe that this is particularly helpful in research on emerging science where potential issues are more difficult to anticipate prior to conducting the research.
Cho et al. point out that IRBs must focus on the potential harms to the individual research subjects, but that it is not within their scope to address potential societal harms. The Stanford Model, however, has the overall goal of “maximizing the benefits and minimizing potential harms of research to society.” Cho et al. believe it is important that their consulting group sets clear boundaries in that it functions solely in an advisory capacity. It does not necessarily have the authority to make binding decisions on the ethical situation. While they believe the scope of their services does not overlap with governing bodies, such as the US Food and Drug Administration or NIH committees or institutional bodies, including IRBs, their recommendations may affect how the investigator interacts with those bodies. In this respect, they see themselves as serving a complementary role.
Roles and Requirements
A key question is whether or not independent consultants or consulting groups address gaps that are not filled by IRBs or other regulating bodies.
One of the arguments in favor of independent consultants is that they are usually comprised of a group of people with varying backgrounds deliberating on an ethical issue. The diversity of perspectives ostensibly provides a more complete assessment of the problem as well as the potential for more creative solutions. They are not confined by regulatory processes. Furthermore, ethics consultants may complement rather than replace IRBs. IRBs play an important role in compliance, and ethics consultants provide counseling on specific issues that arise during research.
The roles of the IRB and the ethics consultant are reminiscent of the difference between that of a school principal and a school counselor. While this is a bit of an oversimplification, the principal typically enforces the school rules so that students behave within the guidelines of the school. This is for the protection of other students and the faculty. The guidance counselor typically helps students navigate their personal situation in the school setting. Different students may have different personal issues, so the counselor’s job is individualized. All students must be in compliance with the school’s rules, so the principal’s job, while dealing with individual cases of non-compliance, is not to necessarily develop individualized solutions for a student in a difficult personal situation.
If the IRB is analogous to the principal, and the ethics consultant(s) is analogous to the guidance counselor, then one can see where the need for a consultant arises in terms of human-subject research. Human subjects are both members of a particular community, and they are unique individuals in unique situations. As evidenced by the in the examples given in the Nature article, IRBs and the consultants can work together to ensure protection of a particular community and to provide guidance for the individual’s particular situation.
Where these relationships become confusing is when the consultant or consulting group also takes on the role of asking how the research affects society, as in the example that Steven Miles of the University of Minnesota gives, “For innovative research designs, you need some independent person to say, ‘Well, let’s step back and think about this not just from the standpoint of do the regulations permit it, but does it fulfil the spirit of what people want done with the public research enterprise?’”
It would seem that asking these larger societal questions is the place for governmental committees, not private consulting groups. This is where the private consultant may overstep its role in some cases. Is the role of the private consultant that of an on-call advisor for difficult ethical issues that arise during research? Or is the consultant’s job to assess the potential harms and repercussions of new research, such as the role that the Presidential Commission for the Study of Bioethical Issues currently plays, along with that of the President’s Council on Bioethics before it?
The Nature article raises some interesting questions, providing support both in favor of and against private consultant roles in human-subject research ethics. It also briefly raises an important point about the nature of scientific investigation that merits further consideration: There is no motivation for scientists to seek out these ethics consultants unless the scientists face legal repercussions. The advocates for ethics consultations assume that scientists would call upon them when an ethical situation arises during the investigation. In reality, some scientists may only care to obtain the “stamp of approval” from the IRB so that they can carry on their research without legal recourse. There is no reason to assume that every scientist would call upon a consultant when an ethically problematic situation arises, particularly if the questionable information is not published and remains confidential.
 Elie Dolgin, “Human-Subjects Research: The Ethics Squad,” Nature, 514, no. 7523 (2014): 418-420. doi: 10.1038/514418a
 Mildred K. Cho, et al. “Strangers at the Benchside: Research Ethics Consultants,” American Journal of Bioethics 8, no. 3 (2008):4-13. doi: 10.1080/15265160802109322
 Dolgin, “Human-Subjects Research,” 420.


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Trudeau’s Liberals Gain in Votes to Fill Canada VacanciesGreg Quinn and Gerrit De Vynck
Canada’s Liberal Party gained a seat and boosted its share of the vote in four special elections held to fill Parliamentary vacancies, gaining support at the expense of both the ruling Conservatives and main opposition New Democratic Party ahead of next year’s general election.
With more than 75 percent of ballots counted, the Liberals had more than half the votes cast in two Toronto-area districts, including Trinity-Spadina, which had been held by the NDP, according to preliminary results posted by Elections Canada. The governing Conservative Party led by Prime Minister Stephen Harper was leading in the two Alberta districts they previously held.
While the Liberals under Justin Trudeau increased their share of the vote from the 2011 election in all four districts, the Conservatives and NDP saw their support fall in all the races. National opinion polls have shown the Liberals ahead of the Conservatives and the NDP, led by Tom Mulcair, since Trudeau became leader in April last year.
“The by-election results suggest a positive showing for the Liberals and worrisome results for the NDP,” Nik Nanos, chairman of Ottawa-based polling firm Nanos Research Group, wrote in an e-mail. “The loss of Trinity-Spadina has to be of particular concern to Mulcair because it is a bellwether riding in battleground Toronto which is critical to both the Liberals and the NDP.”
The Liberals were looking for a strong showing in Fort McMurray-Athabasca, the region at the heart of Alberta’s oil sands industry. Since 1968, the district has never been won by a party other than the Conservatives or their predecessor parties, and Trudeau visited the area during the campaign to build support.
With 79 percent of the polls reporting, Elections Canada reported the Liberals’s share of the vote rising to 34 percent from 10 percent at the last election. While the Conservatives retained the district, their share of the vote fell to 48 percent from 72 percent in 2011.
“Canadians voted for the kind of team that we’re going to be building in the approach to the 2015 election,” Trudeau told about 650 Liberal supporters in Toronto, where he appeared with winning Trinity-Spadina candidate Adam Vaughan. “Albertans are tired of being taken for granted.”
With tonight’s results, The Conservatives will have 162 of the 308 seats in the House of Commons, compared with 98 for the NDP and 37 for the Liberals. The next general election is scheduled for October 2015.
Turnout was very low, with less than 30 percent voting according to preliminary estimates by Elections Canada.

domain: politics


text:
It might never have seemed possible that bustling and historic 19th-century Paris would collide with a small gambling city in the American Southwest. But in 1959, nine decades after the still-running Folies-Bergère opened in France’s capital, Les Folies Bergere opened at Las Vegas’ Tropicana, following the arrival of Lido de Paris a year earlier at the Stardust, further cementing the French-inspired showgirl into a Vegas icon.
Like their European counterparts, these large-scale spectacles with musical numbers, grand staircases, towering headpieces and other feathered and sequined ornamentation paraded the gorgeous women onstage. The remarkable entertainment pipeline between Paris and Vegas brought in Madame Bluebell’s Bluebell Girls and shuttled dancers between the cities, thanks in part to Bluebell’s connection to producer and choreographer Donn Arden.
In French Connection: ‘Lido de Paris’ and ‘Folies Bergere’ in Las Vegas, at UNLV’s Lied Library, photographs, costumes, original sketches and menus—mostly culled from the vast archive in UNLV’s Special Collections—join with costume pieces provided by the Nevada State Museum to celebrate the era.
Sketches of elegant costume and theatrical designs in The French Connection nod to the artistry and creativity that the early shows demanded.
The Stardust’s Lido de Paris production closed in 1991, followed by Les Folies Bergere after nearly five decades at the Tropicana. But the entire Folies wardrobe collection has been donated to the Nevada State Museum, secured by Karan Feder, the museum’s guest curator of costumes and textiles who was also instrumental in the arrival of the wardrobe bibles from the 1981 launch of Jubilee!
Given the number of costumes, oral histories and piles of rich artifacts that still exist at a time when high-tech athletic entertainment now dominates the Strip, we can only hope for a monumental showgirl exhibit painting a broad picture of the heyday. The French Connection, which was curated by Special Collections librarian Karla Irwin and includes pieces imported from the Paris productions as well as elements created here, is a tasty sampling of what that could be like.
The French Connection Through October 1; Monday-Thursday, 7:30 a.m.-midnight; Friday, 7:30 a.m.-7 p.m.; Saturday, 9 a.m.-6 p.m.; Sunday, 11 a.m.-midnight, free. UNLV’s Lied Library, 702-895-2255.


text:
- Top of page
- Materials and methods
Zyxin is an adaptor protein recently identified as a novel regulator of the homeodomain-interacting protein kinase 2 (HIPK2)-p53 signaling in response to DNA damage. We recently reported an altered conformational state of p53 in tissues from patients with Alzheimer ‘s disease (AD), because of a deregulation of HIPK2 activity, leading to an impaired and dysfunctional response to stressors. Here, we examined the molecular mechanisms underlying the deregulation of HIPK2 activity in two cellular models, HEK-293 cells and SH-SY5Y neuroblastoma cells differentiated with retinoic acid over-expressing the amyloid precursor protein, focusing on the evidence that zyxin expression is important to maintain HIPK2 protein stability. We demonstrated that both beta-amyloid (Aβ) 1-40 and 1-42 induce zyxin deregulation, thus affecting the transcriptional repressor activity of HIPK2 onto its target promoter, metallothionein 2A, which is in turn responsible for the induction of an altered conformational state of p53. We demonstrate for the first time that zyxin is a novel target of Aβ activities in AD. These results may help the studies on the pathogenesis of AD, through the fine dissection of events related to beta-amyloid activities.
The protein p53 responds to a variety of cellular stresses and is able to sense the intensity of the damage and modulate biological responses, ranging from transient growth arrest to permanent replicative senescence or apoptosis (Vousden and Prives 2005). One important mechanism that controls p53 function is its conformational stability (Joerger and Fersht 2007). An altered protein conformational state of p53, independent from point mutations, has been reported in tissues from patients with Alzheimer's disease (AD) (Uberti et al. 2006; Lanni et al. 2008; Zhou and Jia 2010). When investigating the mechanism of such alteration, we found that soluble nanomolar concentrations of beta-amyloid (Aβ) 1-40 peptide induced the expression of an unfolded p53 protein isoform and modulated p53 functions by interfering with the homeodomain-interacting protein kinase 2 (HIPK2) (Lanni et al. 2007, 2010), a fundamental protein in maintaining wild-type p53 function (Puca et al. 2008). In particular, soluble Aβ 1-40 inhibited HIPK2 activity, consequently inducting an altered conformational state of p53, and thus resulting in an inability to properly activate an apoptotic program when cells are exposed to a noxious stimulus (Lanni et al. 2010).
A novel regulator of the HIPK2-p53 signaling in response to DNA damage, named zyxin, has been recently identified (Crone et al. 2011). Zyxin is primarily localized at the focal adhesion plaque complex as an adaptor protein (Beckerle 1997; Wang and Gilmore 2003) and contains a proline-rich domain at the N-terminus and three LIM domains at the C-terminus that are cysteine-rich motifs involved in protein–protein interactions. Zyxin is involved in regulating cell adhesion, spreading, and motility but also in transducing signals into the nucleus, to regulate gene expression, cell proliferation, differentiation, and apoptosis (Sadot et al. 2001; Wang and Gilmore 2001). Consistently, zyxin has been demonstrated to shuttle between the cytosol and the nucleus, where it affects transcriptional activity (Degenhardt and Silverstein 2001). In cancer cells, zyxin has been involved in DNA damage-induced cell fate control through the modulation of the HIPK2-p53 signaling. In particular, depletion of endogenous zyxin resulted in proteasome-dependent HIPK2 degradation, thus compromising DNA damage-induced p53 Ser46 phosphorylation dependent from HIPK2 (Crone et al. 2011).
A deregulation of HIPK2 has also been observed in cells treated with Aβ 1-40 (Lanni et al. 2010); however, the molecular mechanisms underlying HIPK2 proteasomal degradation in conditions related to Aβ-exposure need to be investigated. Considering that an altered proportion between Aβ 1-40/Aβ 1-42 as well as an increased production of one of the two species has been indicated as dangerous for the pathogenesis of AD (Verdile et al. 2004; Pangalos et al. 2005; Barten and Albright 2008), our purpose was to first investigate whether a difference in the activation of this pathway exists between the species 1-40 and 1-42, by evaluating the capability of these species to affect the transcriptional repressor activity of HIPK2 onto its target promoter, metallothionein 2A (MT2A). Furthermore, based on data from literature demonstrating that zyxin expression is important in maintaining HIPK2 protein stability (Crone et al. 2011), our second goal was to determine whether a modulation of zyxin is involved in AD pathogenesis, using two cellular models of altered Aβ production. In particular, since in AD an altered metabolism of the amyloid precursor protein (APP) occurred, in turn leading to an aberrant production of Aβ peptides (Verdile et al. 2004), our purpose was also to investigate the effect of Aβ peptides on zyxin mRNA and protein levels. The results showed here may help to better understand the pathogenesis of AD, through the fine dissection of events related to Aβ activities. The characterization of Aβ activity on zyxin-HIPK2 signaling pathway represents a relevant characteristic, since it concerns a research field yet unexplored in a neurodegenerative context.
- Top of page
- Materials and methods
We describe here a link between zyxin-HIPK2-p53 signaling pathway and Alzheimer's disease. We previously demonstrated the existence of Aβ-dependent HIPK2 deregulation responsible for the induction of an unfolded state of p53 protein in fibroblasts from AD patients leading to an impaired and dysfunctional response to stressor (Uberti et al. 2002; Lanni et al. 2008). On the contrary, the non-amyloidogenic product of APP metabolism, sAPPalpha, was demonstrated to be not involved in the regulation of the pathway resulting in conformationally altered p53 (Uberti et al. 2007). Here, we examined the molecular mechanisms underlying the deregulation of HIPK2 activity in two cellular models, HEK-293 and SH-SY5H neuroblastoma cells differentiated with retinoic acid over-expressing the amyloid precursor protein. Recent findings show that zyxin expression is important to maintain HIPK2 protein stability (Crone et al. 2011). Our data suggest that intracellular Aβ peptides may be responsible for zyxin deregulation. This is supported by the observation that Aβ peptides down-regulated zyxin protein levels, compromising HIPK2 stability and thus leading to HIPK2 disappearance from target promoters such as MT2A. In agreement, MT2A mRNA up-regulation was found in HEK-APP cells that over-express APP751. The induction of MT2A, depending on HIPK2 knockdown has been reported to be responsible for p53 misfolding and inhibition of p53 transcriptional activity (Puca et al. 2009); therefore, the present data suggest that zyxin deregulation induced by Aβ peptides might be involved in HIPK2 degradation and in p53 misfolding via MT2A up-regulation in HEK-APP cells. This signaling pathway is further affected in a similar way by both soluble Aβ 1-40 and 1-42 at sublethal concentrations.
To investigate the contribution of APP metabolic products in the modulation of zyxin expression, we used HEK cells over-expressing wild-type APP able to generate high levels of Aβ 1-40 and Aβ 1-42 both intracellularly and secreted in the medium (Uberti et al. 2007). We found that reducing APP amyloidogenic metabolism by treating HEK-APP cells with β- and γ-secretase inhibitors (Lanni et al. 2010) prevented the deregulation of zyxin. It is worth to note that the conditioned medium of HEK-APP cells was able to affect untransfected HEK-293 cells recapitulating the HEK-APP phenotype, in terms of zyxin deregulation.
The data presented in this study suggest that the modulator effects of Aβ peptides on zyxin deregulation are, at least in part, due to the intracellular peptides. Different observations support this conclusion. First, considering that internalization of Aβ can be prevented under experimental conditions that do not allow endocytosis (Knauer et al. 1992), the conditioned media of HEK-APP cells treated with the specific neutralizing antibody 6E10, that recognizes the first 17 aa of the Aβ sequence, were unable to influence zyxin protein levels in HEK-293 cells. Second, we found that the synthetic Aβ peptides added to the cells crossed the plasma membrane, as previously demonstrated (Uberti et al. 2007).
The deregulation of zyxin was further analyzed in SH-SY5Y neuroblastoma cells and their counterpart over-expressing wild-type APP differentiated with retinoic acid. When treating differentiated SH-SY5Y cells with soluble Aβ peptides, both Aβ 1-40 and 1-42 were found to deregulate HIPK2 and decrease zyxin protein levels. Furthermore, also differentiated SY-APP cells are characterized by a decrease in zyxin protein levels, besides showing an HIPK2 down-regulation, thus recapitulating the HEK-APP phenotype in terms of zyxin and HIPK2 deregulation.
Zyxin is preferentially expressed in developing brain and various adult tissues, including lungs, spleen, and testis (Fujita et al. 2009). Depending on its subcellular location, zyxin can have anti-apoptotic or pro-apoptotic function, since zyxin has been shown to promote cell death downstream of apoptotic stimuli such as UV-C irradiation (Hervy et al. 2010), but it has also been implicated in Akt-dependent cardiomyocyte survival pathways (Kato et al. 2005). Zyxin has been extensively studied within a tumoral context, whereas very limited information is present at this time in the literature concerning its putative role in neurodegeneration. In this context, zyxin has been recently identified as an interacting partner for a protein, SIRT1, involved in protection from neurotoxicity in cell-based models for AD/tauopathies, amyotrophic lateral sclerosis and Wallerian degeneration, showing that the interaction of these proteins could be implicated in cellular survival, especially in the brain and heart, during physiological senescence (Fujita et al. 2009). Here, we established for the first time a link between zyxin and Alzheimer's disease. This observation is intriguing, since recent data from the literature support the concept that one or more common molecular mechanisms may be involved in the development of both neurodegenerative diseases and many cancers (Jope et al. 2007; Li et al. 2007; Lu and Zhou 2007; Alves da Costa and Checler 2011; Lanni et al. 2012). Taking into account that cancer and AD share common signaling pathways directing cell fate toward either death or survival, the identification of the putative common mechanisms may be useful to direct neurodegeneration studies toward the same intracellular pathways that have been successfully studied and targeted in cancer.
In summary, we hypothesize that soluble Aβ 1-40 and 1-42 may be responsible for important modulatory effects at cellular level before triggering the amyloidogenic cascade. For the first time, we demonstrated that soluble Aβ 1-40 and 1-42 modulate zyxin protein levels, fundamental in maintaining HIPK2 stability and in turn p53 activity. When zyxin is down-regulated by Aβ peptides, HIPK2 activity is inhibited, with MT2A up-regulation, in turn responsible for the induction of an altered conformational state of p53. As a result of this conformational change, p53 lost its transcriptional activity and was unable to properly activate an apoptotic program when cells were exposed to a noxious stimulus (Fig. 6). The reason why both Aβ 1-40 and Aβ 1-42 have the same effects on this pathway is at the moment under investigation in our laboratory. It is well known that Aβ 1-42 has been reported to aggregate faster than Aβ 1-40 and thus it is considered the most neurotoxic species (Verdile et al. 2004). Moreover, physiologically the 40-amino acid long peptide is the most abundant form (Terai et al. 2001; Kamenetz et al. 2003; Walsh and Selkoe 2007), since the concentration of secreted Aβ 1-42 is about 10% that of Aβ 1-40 (Bitan et al. 2003). However, in pathological conditions, the ratio of their production may be altered, as observed in familial AD cases (Mayeux et al. 1999). On the basis of this observation, one of the issues we should investigate is the differential modulation of this pathway by different concentration ratios of these two species. The sequence of events driven by beta-amyloid here described might contribute to AD pathogenesis since it may result in the presence of dysfunctional cells. Consistently, Yang and co-workers demonstrated the existence of aberrant neurons in AD brain by showing that neurodegeneration is correlated with neurons reentering a lethal cell cycle (Yang et al. 2001; Copani et al. 2007, 2008), which suggests that dysfunctional p53 in non-dividing cells may play a role in aberrant cell cycle progression. Furthermore, the observation that in AD are involved proteins controlling the duplication and cell cycle control leads to the speculation that, in senescent neurons, derangements in proteins commonly dealing with cell cycle control and apoptosis could affect neuronal plasticity and functioning rather than cell duplication.
Figure 6. Working hypothesis for a putative role of zyxin in Alzheimer's disease pathogenesis. The Figure indicates zyxin deregulation mediated by soluble beta-amyloid (Aβ) peptides. When zyxin is down-regulated by sublethal concentrations of Aβ 1-40 or Aβ 1-42, homeodomain-interacting protein kinase 2 (HIPK2) expression and activity are inhibited through degradation via the proteasome system. HIPK2 deregulation results in the induction of metallothionein 2A (MT2A), that exerts its Zn2+ chelator function. As a consequence, p53 changes the wild-type conformation to a conformationally altered status, with subsequent abolishment of wild-type p53 transcriptional activity.
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domain: biology


text:
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domain: health


text:
For years I’d been wanting to see the Wright Brothers National Memorial. I’m not quite sure why, but something about this windy, seaside monument always seemed a little romantic to me. I got a chance to visit when I flew down to the Outer Banks for a wedding on a beautiful and sunny early summer day. The Memorial is a National Park and features several exhibits about the Wright Brother’s historic flights, as well as full scale reproductions of their famous gliders and flying machines.
[these three stones mark the landings of the flights taken on Dec. 17, 1903]
[a sassy portrait of Amelia Earhart ]