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Quiz 1, BICH 410 (MWF3-3:50), Friday, Sept. 17, 1999
Write your name on each page. Clearly circle your response to multiple-choice questions. No partial credit for multiple-choice questions. For other questions, show your work in order to receive partial credit where applicable.
gas constant R 8.315 J/mol-K
1. Structure and ionization of a dipeptide.
A) (7 pts) Draw the structure of the dipeptide, aspartame (asp-phe) that contains a methyl ester on the C-terminus. Do not worry about the correct stereochemistry, but show the ionization of charged groups at pH 7.
Answer: See key for structure. To correctly show the ionization and to answer part B), your answer needs to show i) a protonated (+) amino group on the N-terminus, ii) a deprotonated carboxylate group (-) on the sidechain of asp (aspartic acid), and iii) a methyl ester linkage that blocks the C-terminus and is not ionizable.
B) (4 pts) What is the net charge on aspartame at pH 2? pH 12? You must show your reasoning to obtain full credit for this problem.
Answer: At pH 2 all ionizable groups are protonated because it is below their pK's. Hence the amino terminus contains a + charge and the asp sidechain carboxyl is uncharged. The net charge is +1.
At pH 12 all ionizable groups in this molecule are deprotonated because it is above both pK's. Hence the amino terminus is uncharged and the carboxylate on the asp sidechain is -1. The net charge is -1.
2. (3 pts) Which amino acid from the choices below has the highest isoelectric point?
Answer: D) arginine; From this list arg is the only amino acid that contains a highly basic sidechain (the guanidino group). Hence, the isoelectric point will be shifted to a high pH.
- A) isoleucine
- B) tryptophan
- C) glutamic acid
- D) arginine
- E) histidine
3. (3 pts) The pH of 0.1 mM NaOH is:
Answer: B) 10; The concentration of hydroxide ion is 10-4 M. Therefore pOH = -log[OH-] = - log (10-4) = 4; Since pH + pOH = 14, pH = 14 - pOH = 14 - 4 = 10
- A) 12
- B) 10
- C) 8
- D) 6
- E) 4
4. (3 pts) Which amino acid from the choices below does not contain a sidechain that can participate in a hydrogen bond?
Answer: C) leucine; thr contains a hydroxyl group, tyr contains a phenolic hydroxyl group, gln contains an amide group, and his contains an imidazole group, all of which can participate in hydrogen bonds. The sidechain of leu is an aliphatic hydrocarbon, containing only carbons and hydrogens that cannot participate in hydrogen bonds.
- A) threonine
- B) tyrosine
- C) leucine
- D) glutamine
- E) histidine

domain: chemistry


A former Philadelphia City official and progressive activist is mulling a second run at a statewide office. This time, she’s “gearing up” for Auditor General.
Nina Ahmad, former Deputy Mayor of Philadelphia and one time Democratic candidate for Lt. Governor, is considering a run for Auditor General, according to a spokesperson.
“It’s safe to characterize that she’s gearing up for a run,” said Ken Snyder, a spokesperson for Ahmad, who worked on her 2018 bid for Lt. Gov. “It’s sort of a natural position for her because it’s an advocacy role. It’s standing up for taxpayers and conducting studies and audits and investigations into how that money is being spent.”
Ahmad finished second in the five candidate Democratic primary for Lt. Gov, behind Braddock Mayor and eventual winner John Fetterman. Ahmad captured 23% of the statewide vote, while finishing second in Philadelphia behind incumbent Lt. Gov. Mike Stack. She won the Philadelphia and Harrisburg media markets and finished second in a number of other regions in the state.
Her second place finish in the statewide race makes her a “proven vote getter” according to Snyder.
Prior to her run for Lt. Gov., she announced a bid against longtime Rep. and Chairman of the Philadelphia Democratic Party Bob Brady, but switched races after the redrawing of the state’s Congressional maps and deciding to wanting to take on the “male dominated culture” of Harrisburg.
Snyder said Ahmad is passionate towards holding drug companies accountable, citing her PhD in Chemistry and years in medical research, combating gun violence and holding the NRA accountable, while pointing to her growing up in a civil war in South Asia, and as a women’s rights advocate who called on embattled officials state Sen. Daylin Leach (D-Montgomery) and Philadelphia Sheriff Jewell Williams to resign amid sexual harassment claims. He also added her commitment to strong public schools in the state.
Ahmad has aligned herself with the progressive wing of the Democratic Party and Snyder believes this is an advantage leading into what may be a crowded race to replace outgoing Democratic AG Eugene DePasquale.
“It’s sort of a perfect job for an advocate,” Snyder said. “The position has never really been occupied by a true progressive voice.”
DePasquale secured two terms as AG, while facing very little pushback from the state GOP in both runs, until recently being viewed as a potential candidate for Congress.
Ahmad has yet to officially announce a bid for the position, but Snyder said she’s within weeks of making a decision.


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Don’t miss out! Follow DIYcozyHome.com on Facebook and bring more love and life into your home.
I know we have a lot of readers here with pets and every pet needs a bed right?! So, here’s a really great round up of 25 different pet bed ideas. Mostly these are dog beds but there are a few cat beds mixed in for good measure.
All of these ideas are so fun and creative! Special thanks to The Cottage Market for putting this list together. They have tons of other great DIY ideas on their site too.
Here’s the link to all the pet bed ideas…

domain: pet


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Communicating with Sugarman Rogers through this website does not create an attorney-client relationship with the firm or any of our attorneys. Our decision as to whether and on what terms we may agree to represent a client involves consideration of a variety of factors, discussion with the prospective client, and, where appropriate, a written engagement agreement.
Please do not use this form of communication to transmit any private, personally identifying, or other confidential information. We cannot guarantee the confidentiality or security of this means of communication.
Sugarman Rogers is seeking a family law litigation paralegal. Candidates must be detail-oriented, must be able to work both independently and in a team environment,…
Sugarman Rogers seeks a litigation association to join its team. The ideal candidate will have two to four years of experience in general litigation matters.…

domain: law


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If your car is broken into or your house is burgled in Leeds, the chances are it was by someone with a drug habit.
By David Miller
BBC News Online in Leeds
Keith Lawrence, who heads the government's Leeds Drugs Action Team, estimates there is a hard core of about 500 criminals who are responsible for 80% of the crime committed in the city.
The police regular raid the homes of drugs dealers in Leeds
And the reason they turn to crime is to feed their drugs habit.
Conservative leader Iain Duncan-Smith announced on Thursday that his party would create 10 times as many rehabilitation centres to break this link between drugs and crime.
In Leeds, the hard core criminals are already being offered the chance to take part in drugs rehabilitation programmes.
I went on one raid with the police and we found one 16-year-old with £3,000 in his drawer
Mr Lawrence says: "These are the criminals who cause most disruption to the community.
"There is clear evidence that with the right support they can kick the habit."
Not all drug addicts are criminals though.
There are presently about 2,500 people in drug treatment programmes in the city.
One centre that runs these programmes is Multiple Choice which was visited by Iain Duncan Smith while he was in the city.
Most people who attend Multiple Choice are between 25 and 32 and have been using drugs for an average of seven years.
Project worker Soo Nevison has reservations about constantly linking drugs with crime, pointing out that only half Multiple Choice's clients have a criminal background.
She claims 90% of the people they treat achieve goals they set themselves over drug use at the start of the course.
What they also need is more support in finding housing and a job.
Ms Nevison says: "I have people who say to me 'If I had a roof over my head and a decent job, what would I want in turning to crime?'"
One well-known centre for drug dealing in Leeds was the Hayfield pub in the Chapletown area of Leeds.
This pub closed in July 2002 after police objected to its licence being renewed.
Some local residents say all that has happened is that drug dealers have taken to the local streets.
But the area's Labour MP, Fabian Hamilton, says he is glad such a visible centre drug trading has gone.
Mr Hamilton says West Yorkshire Police are doing a good job in using surveillance and intelligence to target the big drug dealers although it is a continuous fight as the financial rewards can be very high.
"I went on one drug raid with the police," he said, "and we found one 16-year-old boy with £3,000 in cash in his sock drawer and wraps worth £100,000 in the house.
"He's not going to get that sort of money doing any other job."

domain: news


BOZEMAN — Three Bozeman Hawks are officially staying in the Treasure State after putting pen to paper Wednesday signing letters of intent to compete at the next level: Ty Huse (Montana Tech - Men's Basketball), Trent Rogers (Carroll College - Men's Basketball), and Wyatt May (MSU Billings - Cross Country/Track).
“It just felt good to finally kind of finalize it, and having all these people around really made it special for me," Huse smiled.
Ty Huse, a 6-foot-3 guard, played an integral role in taking the Hawks to this year’s State AA championship averaging nearly 16 points per game.
He’s headed to Montana Tech this fall to continue a long lineage of family ties with the Orediggers men’s basketball team.
“It’s really special to me," Huse smiled. "My brother’s there. My dad played there. That’s kind of special to me to be a part of that as well and also just to stay in-state and be close to everybody I know.”
His teammate Trent Rogers is also staying in state after signing with Carroll College, meaning they’ll officially be rivals for the first time ever in their careers competing against one another in the Frontier Conference.
“We’ve been playing since elementary school like back on our travel team the Bozeman Bolts," Huse explained. "We’re going to be enemies on the court but outside that, we’re still the same friends like we always have been.”
“We’re excited," Rogers smiled. "It will be fun. We’ll still stay friends, but when we play each other it will be really fun.”
With both of their new head coaches in attendance — Carroll College's Kurt Paulson and Montana Tech's Adam Hiatt - the celebration was extra special as the two signed their letters of intent.
“I appreciate [Paulson] a lot," Rogers explained. "I feel like I connected with him very well, and the players and the facility. I just like it a lot there.”
“It means a lot to me," Huse stated. "It shows that [Hiatt] cares, and it shows that he wants to be there with me. I appreciate that a lot, especially because he’s going to be my coach for the next four years."]
While Wyatt May is a former teammate of the Huse and Rogers, the 6-foot-4 senior signed with MSU Billings Wednesday for both cross country and track.
“It’s pretty exciting, May beamed. "I’m glad my parents will be able to watch all my races because that’s been a big part of the reason I do this is it’s fun having my parents out. I’m glad they’ll be able to come watch me race.”
In track, May will continue to run the 800, mile, and 3200, but in cross country, he’ll now be running an 8K rather than a 5K.


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With Cinco de Mayo just around the corner, this week we’re getting festive with some quick, simple (and totally delicious) mango salsa!
I love using fresh, sweet, juicy fruits to shake things up in salsa (like my watermelon salsa from last summer). Even though, yes, a tomato is technically a fruit… But we all know he’s more of an honorary member of the fruit club and probably none of the other fruits take him seriously.
There’s something about just the right balance of sweet to spicy that makes a good mango salsa irresistible. I make this frequently as a side dish for cookouts and casual dinner parties and it’s always a hit. And it’s honestly so easy to throw together last minute that you’ll feel like you’re getting away with a crime when people go bananas over your healthy, homemade salsa. (Side note: it turns out bananas do not work well in salsa. Don’t do it.)
- 3 Large tomatoes, cubed
- 1 Medium green bell pepper, chopped
- 2 Large Limes
- 1 Medium Red onion, chopped
- 2 Jalapenos, minced (deseed for less heat if desired)
- 1 Cup fresh cilantro, finely chopped
- 1 Teaspoon Sea salt
This really is about as easy as it gets. You’re going to take all of those chopped ingredients and toss them together in a large bowl. Grate your limes to harvest 1 1/2 tsp of lime zest and pour the zest into a small bowl, along with the juice from both limes and whisk together. Pour the lime juice over the chopped ingredients and mix everything together. Store in an airtight container in the refrigerator and sprinkle your sea salt over the salsa right before serving. And boom. You’re officially a homemade salsa wizard. Go forth. Dip your tortilla chips and snack in victory.
All writing and images copyright © 2018 Rachel Elise Weems Woods

domain: food


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Sunflower in Pot Amigurumi Crochet Pattern
With this clear and easy to follow crochet pattern you can now make your own sunflower!
Needed materials to make this pattern:
Needed skills to make this pattern:
The pattern is written in US crochet terminology and is available in English. The pattern description is written using abbreviations; there’s an extensive list included to explain all abbreviations used. There are also a lot of detailed pictures included to guide you through the pattern.

domain: design


The government of Dubai launches their own crypto currency called emCash, where it is possible to pay for various kinds of state and non-public services.
The first state crypto currency is called emCash and will be used in the purse emPay, launched by Emcredit in order to support contactless payments.
Object Tech Group Ltd, with reference to the state news agency WAM.
According to the Deputy Director of the Ministry of Economic Development Ali Ibrahim, emCash allows strengthening the status of Dubai as a competitive direction, improving the quality of customer service and accelerating the evolution of the emirate into a “smart” economy.
You can pay by new token trough your smartphone; suppliers will receive payments online without intermediaries. The Dubai authorities are confident that the official Crypto currency will completely change the business and the whole lifestyle in the emirate.
Advantages of digital conversion, accelerated payment processing, ease of use, lower transaction costs. In addition, emCash will not be subject to inflation and less susceptible to fraud.
Some time ago, the largest trade and financial forum of the Middle East was held. Within the framework of this conference, several strategic partnerships were concluded, including companies such as IBM and ConsenSys.
In some countries of Europe, in particular in Sweden, cash is losing popularity, and therefore there also think about replacing the krone for crypto currency. The central bank of Sweden estimated that last year only 15% of payments were made in cash, all the rest by mobile wallets, cards and other means, reports MIT Technology Review.
According to Swedish experts, digital money will provide anonymity, but they will not be as volatile as the same bitcoin.
Similar projects are to appear in many countries of the world. So, Estonia was going to launch the first national crypto currency in the world – estcoyin. However the head of the European Central Bank, Mario Drago, shown disagreement: “An EU member state can not enter its currency: the Euro area currency is the Euro.”
In Russia, the Central Bank and the Ministry of Communications declare about the “cyberruble” project. The Chinese authorities also hinted at the possibility of including their own crypto currency. In India, the Central Bank opposed the bitcoins, but for the creation of its own crypto currency.


By Arun Srivastava
Through the “Church House Declaration” around 165 British MPs from across the parties have pledged to form alternative parliament in case the Prime Minister Boris Johnson goes ahead with his plan to prorogue the parliament in the event of Boris failing to make a no-deal Brexit happen.
The Cross-party declaration has described Johnson as a threat to ‘very nature’ of British democracy. The Declaration termed shutting down of parliament as “an undemocratic outrage at such a crucial moment for our country, and a historic constitutional crisis”. It also said: “Any attempt to prevent parliament [from] sitting, to force through a no-deal Brexit, will be met by strong and widespread democratic resistance.”
Ian Blackford, the leader of the Scottish National party in the House of Commons promised: “We will block what is nothing less than a coup.” While the British MPS have hardened their attitude, in a surprising development the EU politicians and leaders are ready to look at “realistic” proposals from Boris on the Irish backstop which according to their parameter has been the main obstacle to a Brexit deal.
Nevertheless some prominent leaders of the EU are quite optimist of Boris government’s chances of coming up with workable ideas. Johnson’s Europe envoy, David Frost, will be in Brussels this week for meetings the officials as both sides strive to avoid a no-deal Brexit on 31 October. Boris Johnson meeting Angela Merkel and Emmanuel in the wake of G7 summit the EU is taking him more seriously as a dealmaker. Nevertheless the EU leaders are not sure of him bringing his party with him.
Significantly the diplomats are “not optimistic” of Boris delivering the desired result: “We haven’t seen anything from the UK yet and therefore there is nothing we can entertain.” There is a general feeling that even if Johnson comes up with proposals that have eluded the May government for the last three years, he has already run out of time to pass them through parliament.
The situation for Johnson has been made difficult by Jeremy Corbyn. Through his calm and sensible political move he has made the opposition and even Tory leaders to come together to foil Boris’s move. Interestingly at a meeting with opposition parties convened by the Labour leader, Corbyn assured MPs that Labour would not seek a premature vote of no confidence that might stymie legislative efforts to stop no deal. He held that holding a general election after an extension is achieved, is the simplest and most democratic way to prevent no deal and to let the people of this country decide our future.
Opponents of Boris are also planning to publish the damaging no-deal preparation documents to win public support. But in a sudden development majority of the Lib Dems, rebel Conservatives and former Tories including Nick Boles have opposed the idea of Corbyn taking over as temporary premier
The political developments taking around Brexit make it absolutely explicit that the UK politics will change for ever. The process has already started. One thing is also evident that party loyalty is a thing of the past. Conservatives had faced some challenging situation in the past but this time it is faced with the worst crisis. Some Conservative leaders nurse the fear that party would face extinction if they delay Brexit. More or less Labour is faced with the same nature of political crisis. Other Labours feel that Corbyn has not been able to handle the issue in a more prudent manner and for that the party has lost some ground in recent months. Even the old friends of Corbyn have turned his critics.
AS the situation stands out, all the Labour MPs will not vote for Corbyn’s strategy. In such a backdrop he needs a large number of Tory rebels. And this undoubtedly is not going to happen either unless they get something that they want. One political implication ought to be analysed seriously is the forces that would join hand with Corbyn. He would form the temporary government on the terms of its most centrist supporters in the House. Corbyn cannot be expected to follow and practice his left politics and that is a big dilemma for the left leader. (IPA Service)


The ultimate comfort
When it comes to going for the best bed sheets in the market, no one would prefer compromising silk sheets. Apart from being cool and comfortable to the skin, it provides the ultimate care to the user and truly allows them to enjoy the bedrooms’ warmth truly. Some journals have proven the health benefits of silk sheets and how do they symbolize comfort. But, along with this comfort also comes the issue of sliding off.
Read on to know ways of preventing the same, including about silk sheets king.
Silk sheets are prone to constant sliding from the corners of the bed. And when it comes to kids, the situation gets tenser. They keep taking frequent turns on the sheet, and the next thing you realize is that the entire sheet is out of the bedding. Therefore, there are some established methods of preventing the issue and ensuring the intactness of the bed.
The following methods showcase the ways of preventing silk sheet sliding, coming right out of silk sheets king:
- Securing the sheets with straps, where long elastic bands fit horizontally at the bottom or corners prone to frequent sliding. This helps in fastening the sheet on the bed and avoiding the issue all at once.
- Bed clippings provided on the bed legs allow the sheet to stay intact and prevent going all the way down to the floor. The clipping device maintains the horizontal and vertical motions and prevents any further issues.
- The perfect art of tucking, where the elongated sides of the sheet are tucked along the feet of the bed. This provides the required grip and allows the bedding to stay without getting spoiled further.
All in one, it is fairly easy to maintain such techniques and prevent sheets from sliding off.


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London, 25 July – Germany is considering new laws that would allow it to respond actively to cyber-attacks from foreign countries, according to Interior Minister Horst Seehofer when he presented a domestic intelligence agency report that identified Iran as the latest foreign power to dramatically increase attacks on German systems.
The report, which was released by the domestic intelligence service (BfV) on Tuesday, explained that the number of Iran-linked cyber attacks on Germany had been rising since 2014 and had seen a sharp increase in 2017.
Seehofer explained that the German intelligence agencies needed the power to launch counter-measures against such attacks, rather than merely being able to track and clean up cyber-attacks.
Seehofer said: “We will maybe need changes to the law on the question of how to react actively, not just investigating, but also actively (responding).”
Iran’s cyber attacks were mainly at the German government, Iranian opposition figures, human rights organisations, research centres and the aerospace, defence and petrochemical industries.
The report said: “The observed cyber campaigns are developing such efficacy that the operations initiated and guided by intelligence agencies to gain information could pose a danger to German companies and research institutions.”
These Iran-linked cyber attacks are coming at a very sensitive time for Germany, which is currently trying to salvage the Iranian nuclear deal that the US withdrew from in May.
The deal, which lifts sanctions on Iran in exchange for supposed restrictions on their nuclear programme, was called the “worst deal ever” by Donald Trump when he pulled out of it citing major flaws.
The US will soon begin enforcing nuclear sanctions on Iran that were lifted under former President Barack Obama.
Germany’s other worries
Of course, cyber-attacks are not Iran’s only troubling behaviour. Germany has also voiced concerns over Iran’s missile development, support for terrorism, and espionage.
In January, Germany’s foreign ministry told Iran’s ambassador that spying on people and groups linked to Israel was an “unacceptable” breach of German law.
While in late June and early July, European authorities discovered that Iran was planning to bomb the Free Iran rally, organised by the Iranian Resistance, in Paris.
The gathering was attended by many prominent figures throughout the world, including former heads of state and current ministers. In total, 100,000 were in attendance, including many thousands of civilians.
The Iranian Ambassador to Vienna was arrested by German authorities for his role in organising the attack and directing the would-be terrorists, who were arrested by Belgian authorities. He will soon be sent to Belgium to face terrorism charges.

domain: politics


The Presbyterian church of Ghana-Koforidua Ascension branch, will host some of the finest of Ghanaian gospel artistes on Sunday,27th August 2017 as gospel artiste Paa Sammy launches his latest and first album tittled “OBOAFO” literally means “My helper”.
Some of the artistes
billed to support maltifarious gospel artiste Paa Sammy at the launch are,the “Tabi Takum” hit maker,Nicholas Omane Acheampong,Fred Oware Junior,Kobby Isaac Jeffery and many others.
When Kumikasa.com contacted his management,They said some notable personalities such as Rev. Nana Ampem Darko,Rev Foster Ampofo and many other important personalities will grace the launch.
“The host on the night,Odehyieba Kwesi of Good life 105.5 Fm,Asendua of Good life Fm and a host of other Radio presenters will be present to give their ‘senior brother’ support on that special day,” management divulged.
The album which is already available on Kumikasa.com and other internet platforms for downloads features a lot of great and talented gospel artistes.
“This new album seeks to inspire Christians and people from all walks of life to appreciate the work of God and to believe in the saving power of God in times of difficulties,” Paa Sammy disclosed in an interview with Kumikasa.com.
“Nothing good comes on a silver platter and the target for this album isn’t just for the people of Eastern Region but the whole Ghana and the world so we needed the best hands to work on it” says the gospel sensation Paa Sammy


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Duquesne board rejects transfer plan
Duquesne City School District's board of directors voted 8-0 with one abstention on Thursday to reject a financial recovery plan presented by state-appointed chief recovery officer Paul B. Long.
“We did not get a chance to digest that plan,” board president Dewayne Tucker said.
No one in an audience of approximately 50 in attendance spoke in favor of the plan.
Now Allegheny County Court of Common Pleas will appoint a receiver to implement Long's scenario of voluntary transfers of elementary students to other districts.
The court is expected to take the case on Tuesday.
Pennsylvania Department of Education spokesman Tim Eller said state education secretary Ronald Tomalis will petition the county court within five days, as required by the School District Financial Recovery Act 141.
The Duquesne board's next regular meeting is scheduled for Tuesday at 7 p.m.
Voting no were Tucker, board vice president Calvina Harris and Sonya Chambers, Laura Elmore, Rosia Reid, Cedric Robertson, Maxine Thomas and Theresa Thomas. Reid voted by telephone.
Director Burton Comensky abstained.
“I didn't particularly want to vote it down,” Comensky said, “and I didn't want to vote against the board.”
Long proposed sending Duquesne students to a district where schools meet Adequate Yearly Progress on Pennsylvania System of School Assessment tests and accept a tuition of $8,000 each.
He had 11 districts in mind:
• East Allegheny and West Mifflin Area.
• Elizabeth Forward and South Allegheny, both of which have rejected the plan.
• Pittsburgh, whose administrators ran Duquesne's operations during 2006-07.
• West Jefferson Hills, where Allegheny Intermediate Unit director Linda Hippert is interim superintendent. AIU ran Duquesne operations from 2007 to 2011.
• Baldwin-Whitehall, Brentwood, Gateway, Norwin and South Park Township.
“This is not in our children's best interest to send (them) that far,” resident Lina Washington said.
“East Allegheny is far enough,” Whitmore said. “And every road going out to South Park is screwed up.”
“Why don't we send them to a private school?” asked parent Keith Whitmore. He suggested that Serra Catholic High School in McKeesport might be a cheaper option.
“I would rather my daughter go to (a) charter school,” parent Keith Thomas said.
“They have done no research on the effects this will have on our children,” charter school advocate Connie Lucas said. “We refuse to have our children exported miles and miles from their parents, where they can't get to them if there is an emergency.”
If the Duquesne receiver can't get other districts to accept the city's students by fall, Long said, “then we will need to continue to plan to have (kindergarten through sixth grade) here.”
The Rev. Carolyn Perrin reiterated arguments she and her husband, the Rev. Archie Perrin, made at public forums and before the board on Tuesday.
She decried “gross negligence” in “this so-called recovery plan.” She pointed again to how Duquesne scores are not counted in the PSSA ratings of East Allegheny or West Mifflin Area high schools. Duquesne youngsters have been sent to those schools by state mandate since 2007.
“You could have educated them better yourself here for less money,” Carolyn Perrin said.
Her husband Archie Perrin, the outgoing Wilkinsburg superintendent, a former Duquesne administrator and pastor of Macedonia Baptist Church, was unable to attend the meeting.
“We are talking about people's lives here and their children's lives and their future,” Archie Perrin said on Wednesday. “They have not considered the short-term or the long-term effect.”
Robert Stump, a retired AIU consultant who raised seven children in Duquesne, suggested that the board “take a little more time before you vote.”
Solicitor Andrew Evankovich said there was no time, because under the financial recovery act the board was at the end of a 10-day period for considering Long's plan.
Eller also said Act 141 “states that the district shall not be eligible for a financial recovery transitional loan and technical assistance from the department.”
Before the vote, however, Long said the district would not get a $6,785,000 transitional loan that was in his plan because the department told him the money was not available. Eller did not have an response at presstime.
Had the board voted yes, Long said he also would have pursued $1 million in state funds for technical assistance.
Patrick Cloonan is a staff writer for Trib Total Media. He can be reached at 412-664-9161, ext. 1967, or firstname.lastname@example.org.


In order to participate in the GunBroker Member forums, you must be logged in with your GunBroker.com account. Click the sign-in button at the top right of the forums page to get connected.
Remington 760 35 Rem Magazine
Dokey Member Posts: 933 ✭✭✭
WTB Looking for a mag for a Remington 760 in 35 Rem Cal
Will this work?
No, I checked and the 35 Whelen and 35 Remington are different


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Our goal is to deliver the best, trusted financial solutions.

domain: economics


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WASHINGTON — Faced with global warming, plants are heading for the hills.
A study of 171 forest species in Western Europe shows that most of them are shifting their favored locations to higher, cooler spots.
For the first time, research can show the “fingerprints of climate change” in the distribution of plants by altitude, and not only in sensitive ecosystems, said Jonathan Lenoir of AgroParisTech in Nancy, France.
His team found “a significant upward shift of species optimum elevation, the altitude where species are the most likely to be found over their whole elevation range.”
Indeed, comparing the distribution of species between 1905 and 1985 with that of 1986 to 2005 showed a shift upward of 95 feet per decade, researchers led by Lenoir reported in Friday’s edition of the journal Science.
The team studied the preferred location of plants from sea level up to more than 8,500 feet in six regions in France. AgroParisTech is the agricultural branch of the Paris Institute of Technology.
This shows that the effects of climate change are being felt in all areas, not just mountain summits and polar regions, explained co-author Pablo Marquet of the Pontifical Catholic University of Chile.
Unlike animals, of course, plants can’t just pick up and move in search of a better home.
But plant species do move, as seeds that are spread tend to grow better in one place than another — in this case, at higher elevations in preference to lower ones.
Quickest to relocate, not surprisingly, were plants such as herbs, ferns and mosses with shorter life spans and faster reproduction cycles, the researchers said.
Not so fleet were large woody plants that reproduce slowly. Long-lived plants like trees that reproduce slowly are more threatened by climate change because they can’t quickly relocate, Lenoir said.
Herbs, by having a short life cycle, have had several generations while trees have had just one, noted co-author Jean-Claude Gegout of Agro-ParisTech.
The plants studied tended to be the most common ones in the mountain forests of France, Lenoir said, allowing the researchers to collect the largest possible amount of information.
Of the 171 species studied, 118 moved uphill and 53 edged downward, the researchers said. “Individual species behave differently, but as a whole the set of species we studied shows a clear and significant response associated to a shift in their distribution upwards,” Lenoir said via e-mail.

domain: biology


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Sterling Silver Claddagh Ring with intricately sculpted detail. Encircled by Cubic Zirconia shines a brilliant Emerald Green Cubic Zirconia Heart.
The Claddagh Ring is rich in Celtic Culture. There are varying tales of origin regarding the first Claddagh Ring, although all Claddagh imagery features two joining hands for friendship, a Crown for Loyalty and a Heart to symbolize Love. Lore of the ring extends to the fashion in which the Ring is worn, also. Married or engaged individuals wear the ring on their left hand. If the Crown points away from the person wearing it, thus pointing away from the heart, it means the wearer is taken. A person can display it on the right hand with the Crown facing outward to indicate they are looking for love, and wear it with the crown facing towards the heart, inward, if they have no interest in seeking love. The Green of this beautiful jewel is suggestive of the Emerald Isle. The striking Green color is a nod to nature, growth and the personal gain of wealth in life, love and happiness.
Gift this to your sweetheart as a promise ring or wear it to showcase your Irish culture and pride. Whatever your personal reason for displaying this lovely piece on your hand it is a bold statement ring sure to strike a little green in the eyes of those who lay their gaze on it.
Collections: #MadeLocal Claddagh Rings Jewellery Shanore

domain: artistic


text:
Tips to help you lower your risk of developing breast cancer
7:00 AM, Oct 15, 2013
(WXYZ) - October is Breast Cancer Awareness Month—a good time to take charge of your health.
Many of us have a family member, friend or co-worker who had or has breast cancer. It may even be you. After non-melanoma skin cancer, breast cancer is the second most common type of cancer in American women. The National Cancer Institute estimates more than 200,000 women in the United States will develop breast cancer this year alone.
Take action in these six ways to lower your risk:
Maintain a healthy weight.
Eat a low-fat diet with lots of fruit and vegetables.
Avoid hormone replacement therapy or learn about its risks and benefits before you consider it.
Lower or limit the amount of alcohol you drink.
Get screened for breast cancer regularly.
When it comes to breast cancer, early detection is the best defense. When caught early, many women with will go on to live long and healthy lives.
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domain: medical


Apple outs iPhone micro USB adaptor
Euro-standard power feed
It's not only the iPhone 4S that will ship on 14 October - so too will Apple's long-promised dock-to-micro-USB adaptor.
Punters eager to "use third-party micro USB cables and chargers to sync or charge your iPhone" will be able to do so for a mere consideration of £8.
Apple promised in February 2011 that it would add micro USB compatibility to the iPhone during the course of the year.
Its pledge followed a European Commission scheme to establish micro USB as a standard form of charger interface for smartphones, the better to ensure fewer chargers need ship, resulting in less electronics waste. ®
Missed the point much Apple?
You can do everything with USB
Everything you can do with the proprietary Apple Dock Connector, can already be done with microUSB.
The difference is, Apple can't claim income (licensing fees) from microUSB as they do now with their proprietary Dock Connector, nor would Apple be able to maintain their iron grip on what third party products are permitted to interface with their iDevices.
It's not about the end user, convenience and flexibility. As usual, it's about Apple maintaining control and increasing revenue (heck, they even get to charge you £8 for another adaptor you shouldn't really need in the first place!)
Only a fanboi would attempt to argue differently.
"I've got 5 micro USB chargers sitting in my drawers, what am I supposed to do with them?"
Dunno. Maybe a hemorrhoid cushion will alleviate the discomfort?
"to ensure fewer chargers need ship"
One still ships with every mobe, regardless of whether it needs to. I'm all in favour of standardisation in this area, but if it's to have any real effect, chargers should stop shipping with new phones by default, and be bought separate instead. I've got 5 micro USB chargers sitting in my drawers, what am I supposed to do with them?
But does it suffer from RAM pack wobble?
No doubt the press release says stuff like "it's wonderful" and "we appreciate everyone who has waited patiently while we’ve worked to get every detail right"... What other phones offer built-in and standard since before the iPhone 4 was launched, Apple has managed to turn into yet another way to fleece a bit more money out of their cult members.


text:
Osteogenesis imperfecta (OI) is a collagen-related disorder associated to dominant, recessive or X-linked transmission, mainly caused by mutations in type I collagen genes or in genes involved in type I collagen metabolism. Among the recessive forms, OI types VII, VIII, and IX are due to mutations in CRTAP, P3H1, and PPIB genes, respectively. They code for the three components of the endoplasmic reticulum complex that catalyzes 3-hydroxylation of type I collagen α1Pro986. Under-hydroxylation of this residue leads to collagen structural abnormalities and results in moderate to lethal OI phenotype, despite the exact molecular mechanisms are still not completely clear. To shed light on these recessive forms, primary fibroblasts from OI patients with mutations in CRTAP (n=3), P3H1 (n=3), PPIB (n=1) genes and from controls (n=4) were investigated by a functional proteomic approach. Cytoskeleton and nucleoskeleton asset, protein fate, and metabolism were delineated as mainly affected. While western blot experiments confirmed altered expression of lamin A/C and cofilin-1, immunofluorescence analysis using antibody against lamin A/C and phalloidin showed an aberrant organization of nucleus and cytoskeleton. This is the first report describing an altered organization of intracellular structural proteins in recessive OI and pointing them as possible novel target for OI treatment.
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