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Women who deal with gestational diabetes in their first or second pregnancy are far more likely to develop the condition again in their third pregnancy, according to a new study from Kaiser Permanente that examined the electronic medical records of 65,132 women. The study was published online in the American Journal of Obstetrics and Gynecology last month.
0 comments - Aug 11, 2010 -
Most women with gestational diabetes know that taking steps to manage the disease during pregnancy is critical for the health of both mother and child. What many women don't realize is that those steps need to continue even after the baby is born.
0 comments - May 7, 2010 -
The first concrete evidence of a genetic link between low birth weight and the potential for developing type 2 diabetes has been published in the April 6 issue of the journal Nature Genetics. Scientists previously believed that lower birth weight babies were more at risk, but the cause remained unclear.
0 comments - Apr 11, 2010 -
Suggested revisions in the benchmarks used to assess dangerously high blood sugar levels in pregnant women could lead to a doubling or tripling of the number of women diagnosed with gestational diabetes*. That's the conclusion of an international study led by the Northwestern University Feinberg School of Medicine in Chicago.
0 comments - Mar 24, 2010 -
A 20-year study that tracked 704 women from before their first pregnancy onward suggests that the first year mothers breastfeed, they reduce their risk of acquiring type 2 diabetes within the next 15 years by 15 percent. Each subsequent year of breastfeeding further reduces the risk by 15 percent. For example, a mother who has two children and breastfeeds each for a year could enjoy a 30 percent reduction in her risk of type 2 over a 15-year period.
2 comments - Dec 25, 2009 -
NEW YORK (Reuters Health) Oct 13 - Women with metabolic syndrome in early pregnancy have a higher risk for preterm birth, according to study findings reported in the October 1st issue of the American Journal of Epidemiology.
0 comments - Oct 16, 2009 -
Nature is wonderfully complex. During the second trimester of pregnancy, when the fetus is growing rapidly, hormones from the placenta begin to reduce the ability of the mother's insulin to bind with insulin receptors. Because the mother's insulin is consequently less able to shuttle glucose out of her bloodstream, the growing fetus is guaranteed a good supply of blood glucose.
0 comments - Oct 6, 2009 -
The Organic Center (TOC), a leading research institute focused on the science of organic food and farming, announced that a balanced, organic diet-both before and during pregnancy-can significantly reduce a child's likelihood of becoming overweight or obese or developing diabetes.
1 comment - Jul 17, 2009 -
Women who frequently snore-at least three nights a week-run a substantially higher risk of developing gestational diabetes during pregnancy than non-snorers.
0 comments - Jul 9, 2009 -
There is an old schoolyard chant that starts out with an image of two people "sitting in a tree" and "K-I-S-S-I-N-G." This is followed by, "First comes love, then comes marriage, then comes the baby in the baby carriage." The natural progression of life is to find one's "soul mate," tie the knot, and then have children.
37 comments - Apr 17, 2009 -
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.

domain: biology


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United Nations’ expert on extreme poverty names and shames profitable US giants Amazon, Walmart and DoorDash.
More companies have added their voices to the call to make the EU Corporate Sustainability Due Diligence Directive align with UN standards.
The ICGN also seeks clarity on what role boards will play in supervising due diligence under the forthcoming EU directive.
A letter to the European Union asks that definitions in the coming directive are consistent with guidelines from the UN and OECD.
Campaigners ask European Council to widen the ambit of EU Corporate Sustainability Due Diligence directive.
Companies that take human rights due diligence seriously tend to lead on the issue from the top, finds global benchmarking report.
Businesses looking overseas for innovative solutions to supply chain disruption need to be aware of the potential for ESG-related litigation.
Companies including Ikea, Danone and Aviva Investors have signed a letter calling on the EU to accelerate its work on human rights proposals.
Push for due diligence comes as part of a roadmap aiming to embed use of the UN’s Guiding Principles on Business and Human Rights.
Campaign groups have warned that due diligence on human rights should remain central to organisations’ response to the Covid-19 pandemic.

domain: news


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During flu season, sufferers are advised to prevent spreading the virus by covering their mouths when coughing or sneezing and by washing their hands. But these methods may not be enough, according to a new study by Harvard School of Public Health (HSPH) researchers and colleagues.
According to the study, which was published March 7, 2013 in PLOS Pathogens, infected people exhale flu virus particles of varying sizes, and the smallest particles contained the highest concentration of flu virus. These small particles would not be expected to be stopped by traditional flu hygiene methods.
“Our study suggests that flu virus in small particles (less than 0.5 microns) may play a larger role than traditionally thought in the spread of influenza,” said James McDevitt, instructor in HSPH’s Exposure, Epidemiology, and Risk Program. It had previously been assumed that larger particles were associated with flu transmission, he said.
The researchers also found that by wearing masks, study participants infected with the flu had a 25 fold decrease in the amount of large virus particles they exhaled compared with those not wearing a mask. Decreases for small particles were a more modest 2.8 fold reduction.
While the U.S. Centers for Disease Control recommends that doctors and hospitals provide their flu patients with face masks, little is known about the infectiousness of exhaled particles and the effectiveness of masks in preventing their spread.


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Diffusion tensor imaging (DTI) techniques provide information on the microstructural processes of the cerebral white matter (WM) in vivo. The present applications are designed to investigate differences of WM involvement patterns in different brain diseases, especially neurodegenerative disorders, by use of different DTI analyses in comparison with matched controls.
DTI data analysis is performed in a variate fashion, i.e. voxelwise comparison of regional diffusion direction-based metrics such as fractional anisotropy (FA), together with fiber tracking (FT) accompanied by tractwise fractional anisotropy statistics (TFAS) at the group level in order to identify differences in FA along WM structures, aiming at the definition of regional patterns of WM alterations at the group level. Transformation into a stereotaxic standard space is a prerequisite for group studies and requires thorough data processing to preserve directional inter-dependencies. The present applications show optimized technical approaches for this preservation of quantitative and directional information during spatial normalization in data analyses at the group level. On this basis, FT techniques can be applied to group averaged data in order to quantify metrics information as defined by FT. Additionally, application of DTI methods, i.e. differences in FA-maps after stereotaxic alignment, in a longitudinal analysis at an individual subject basis reveal information about the progression of neurological disorders. Further quality improvement of DTI based results can be obtained during preprocessing by application of a controlled elimination of gradient directions with high noise levels.
In summary, DTI is used to define a distinct WM pathoanatomy of different brain diseases by the combination of whole brain-based and tract-based DTI analysis.
19 Related JoVE Articles!
Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
Institutions: Stanford University , Duke University Medical Center, Duke University .
Although mice are the dominant model system for studying the genetic and molecular underpinnings of neuroscience, functional neuroimaging in mice remains technically challenging. One approach, Activation-Induced Manganese-enhanced MRI (AIM MRI), has been used successfully to map neuronal activity in rodents 1-5
. In AIM MRI, Mn2+
acts a calcium analog and accumulates in depolarized neurons 6,7
. Because Mn2+
shortens the T1
tissue property, regions of elevated neuronal activity will enhance in MRI. Furthermore, Mn2+
clears slowly from the activated regions; therefore, stimulation can be performed outside the magnet prior to imaging, enabling greater experimental flexibility. However, because Mn2+
does not readily cross the blood-brain barrier (BBB), the need to open the BBB has limited the use of AIM MRI, especially in mice.
One tool for opening the BBB is ultrasound. Though potentially damaging, if ultrasound is administered in combination with gas-filled microbubbles (i.e., ultrasound contrast agents), the acoustic pressure required for BBB opening is considerably lower. This combination of ultrasound and microbubbles can be used to reliably open the BBB without causing tissue damage 8-11
Here, a method is presented for performing AIM MRI by using microbubbles and ultrasound to open the BBB. After an intravenous injection of perflutren microbubbles, an unfocused pulsed ultrasound beam is applied to the shaved mouse head for 3 minutes. For simplicity, we refer to this technique of BBB Opening with Microbubbles and UltraSound as BOMUS 12
. Using BOMUS to open the BBB throughout both cerebral hemispheres, manganese is administered to the whole mouse brain. After experimental stimulation of the lightly sedated mice, AIM MRI is used to map the neuronal response.
To demonstrate this approach, herein BOMUS and AIM MRI are used to map unilateral mechanical stimulation of the vibrissae in lightly sedated mice 13
. Because BOMUS can open the BBB throughout both hemispheres, the unstimulated side of the brain is used to control for nonspecific background stimulation. The resultant 3D activation map agrees well with published representations of the vibrissae regions of the barrel field cortex 14
. The ultrasonic opening of the BBB is fast, noninvasive, and reversible; and thus this approach is suitable for high-throughput and/or longitudinal studies in awake mice.
Neuroscience, Issue 65, Molecular Biology, Biomedical Engineering, mouse, ultrasound, blood-brain barrier, functional MRI, fMRI, manganese-enhanced MRI, MEMRI
DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions
Institutions: Centre Hospitalier de Luxembourg, University of Applied Sciences Trier, Erasmus Universiteit Rotterdam, Centre Hospitalier de Luxembourg.
DTI is a technique that identifies white matter tracts (WMT) non-invasively in healthy and non-healthy patients using diffusion measurements. Similar to visual pathways (VP), WMT are not visible with classical MRI or intra-operatively with microscope. DTI will help neurosurgeons to prevent destruction of the VP while removing lesions adjacent to this WMT. We have performed DTI on fifty patients before and after surgery between March 2012 to January 2014. To navigate we used a 3DT1-weighted sequence. Additionally, we performed a T2-weighted and DTI-sequences. The parameters used were, FOV: 200 x 200 mm, slice thickness: 2 mm, and acquisition matrix: 96 x 96 yielding nearly isotropic voxels of 2 x 2 x 2 mm. Axial MRI was carried out using a 32 gradient direction and one b0-image. We used Echo-Planar-Imaging (EPI) and ASSET parallel imaging with an acceleration factor of 2 and b-value of 800 s/mm². The scanning time was less than 9 min.
The DTI-data obtained were processed using a FDA approved surgical navigation system program which uses a straightforward fiber-tracking approach known as fiber assignment by continuous tracking (FACT). This is based on the propagation of lines between regions of interest (ROI) which is defined by a physician. A maximum angle of 50, FA start value of 0.10 and ADC stop value of 0.20 mm²/s were the parameters used for tractography.
There are some limitations to this technique. The limited acquisition time frame enforces trade-offs in the image quality. Another important point not to be neglected is the brain shift during surgery. As for the latter intra-operative MRI might be helpful. Furthermore the risk of false positive or false negative tracts needs to be taken into account which might compromise the final results.
Medicine, Issue 90, Neurosurgery, brain, visual pathway, white matter tracts, visual cortex, optic chiasm, glioblastoma, meningioma, metastasis
In vivo 19F MRI for Cell Tracking
Institutions: Radboud University Medical Center, Max Planck Institute for Neurological Research, German Center for Neurodegenerative Diseases (DZNE).
In vivo 19
F MRI allows quantitative cell tracking without the use of ionizing radiation. It is a noninvasive technique that can be applied to humans. Here, we describe a general protocol for cell labeling, imaging, and image processing. The technique is applicable to various cell types and animal models, although here we focus on a typical mouse model for tracking murine immune cells. The most important issues for cell labeling are described, as these are relevant to all models. Similarly, key imaging parameters are listed, although the details will vary depending on the MRI system and the individual setup. Finally, we include an image processing protocol for quantification. Variations for this, and other parts of the protocol, are assessed in the Discussion section. Based on the detailed procedure described here, the user will need to adapt the protocol for each specific cell type, cell label, animal model, and imaging setup. Note that the protocol can also be adapted for human use, as long as clinical restrictions are met.
Medicine, Issue 81, Animal Models, Immune System Diseases, MRI, 19F MRI, Cell Tracking, Quantification, Cell Label, In vivo Imaging
Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
Institutions: Sunnybrook Health Sciences Centre, University of Toronto.
Obtaining in vivo
human brain tissue volumetrics from MRI is often complicated by various technical and biological issues. These challenges are exacerbated when significant brain atrophy and age-related white matter changes (e.g.
Leukoaraiosis) are present. Lesion Explorer (LE) is an accurate and reliable neuroimaging pipeline specifically developed to address such issues commonly observed on MRI of Alzheimer's disease and normal elderly. The pipeline is a complex set of semi-automatic procedures which has been previously validated in a series of internal and external reliability tests1,2
. However, LE's accuracy and reliability is highly dependent on properly trained manual operators to execute commands, identify distinct anatomical landmarks, and manually edit/verify various computer-generated segmentation outputs.
LE can be divided into 3 main components, each requiring a set of commands and manual operations: 1) Brain-Sizer, 2) SABRE, and 3) Lesion-Seg. Brain-Sizer's manual operations involve editing of the automatic skull-stripped total intracranial vault (TIV) extraction mask, designation of ventricular cerebrospinal fluid (vCSF), and removal of subtentorial structures. The SABRE component requires checking of image alignment along the anterior and posterior commissure (ACPC) plane, and identification of several anatomical landmarks required for regional parcellation. Finally, the Lesion-Seg component involves manual checking of the automatic lesion segmentation of subcortical hyperintensities (SH) for false positive errors.
While on-site training of the LE pipeline is preferable, readily available visual teaching tools with interactive training images are a viable alternative. Developed to ensure a high degree of accuracy and reliability, the following is a step-by-step, video-guided, standardized protocol for LE's manual procedures.
Medicine, Issue 86, Brain, Vascular Diseases, Magnetic Resonance Imaging (MRI), Neuroimaging, Alzheimer Disease, Aging, Neuroanatomy, brain extraction, ventricles, white matter hyperintensities, cerebrovascular disease, Alzheimer disease
Training Synesthetic Letter-color Associations by Reading in Color
Institutions: University of Amsterdam.
Synesthesia is a rare condition in which a stimulus from one modality automatically and consistently triggers unusual sensations in the same and/or other modalities. A relatively common and well-studied type is grapheme-color synesthesia, defined as the consistent experience of color when viewing, hearing and thinking about letters, words and numbers. We describe our method for investigating to what extent synesthetic associations between letters and colors can be learned by reading in color in nonsynesthetes. Reading in color is a special method for training associations in the sense that the associations are learned implicitly while the reader reads text as he or she normally would and it does not require explicit computer-directed training methods. In this protocol, participants are given specially prepared books to read in which four high-frequency letters are paired with four high-frequency colors. Participants receive unique sets of letter-color pairs based on their pre-existing preferences for colored letters. A modified Stroop task is administered before and after reading in order to test for learned letter-color associations and changes in brain activation. In addition to objective testing, a reading experience questionnaire is administered that is designed to probe for differences in subjective experience. A subset of questions may predict how well an individual learned the associations from reading in color. Importantly, we are not claiming that this method will cause each individual to develop grapheme-color synesthesia, only that it is possible for certain individuals to form letter-color associations by reading in color and these associations are similar in some aspects to those seen in developmental grapheme-color synesthetes. The method is quite flexible and can be used to investigate different aspects and outcomes of training synesthetic associations, including learning-induced changes in brain function and structure.
Behavior, Issue 84, synesthesia, training, learning, reading, vision, memory, cognition
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
Institutions: University of Montréal, McGill University, University of Minnesota.
Transcranial direct current stimulation (tDCS) is a neuromodulation technique that has been increasingly used over the past decade in the treatment of neurological and psychiatric disorders such as stroke and depression. Yet, the mechanisms underlying its ability to modulate brain excitability to improve clinical symptoms remains poorly understood 33
. To help improve this understanding, proton magnetic resonance spectroscopy (1
H-MRS) can be used as it allows the in vivo
quantification of brain metabolites such as γ-aminobutyric acid (GABA) and glutamate in a region-specific manner 41
. In fact, a recent study demonstrated that 1
H-MRS is indeed a powerful means to better understand the effects of tDCS on neurotransmitter concentration 34
. This article aims to describe the complete protocol for combining tDCS (NeuroConn MR compatible stimulator) with 1
H-MRS at 3 T using a MEGA-PRESS sequence. We will describe the impact of a protocol that has shown great promise for the treatment of motor dysfunctions after stroke, which consists of bilateral stimulation of primary motor cortices 27,30,31
. Methodological factors to consider and possible modifications to the protocol are also discussed.
Neuroscience, Issue 93, proton magnetic resonance spectroscopy, transcranial direct current stimulation, primary motor cortex, GABA, glutamate, stroke
Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Institutions: Alpert Medical School, Brown University, University of Georgia.
Complementary structural and functional neuroimaging techniques used to examine the Default Mode Network (DMN) could potentially improve assessments of psychiatric illness severity and provide added validity to the clinical diagnostic process. Recent neuroimaging research suggests that DMN processes may be disrupted in a number of stress-related psychiatric illnesses, such as posttraumatic stress disorder (PTSD).
Although specific DMN functions remain under investigation, it is generally thought to be involved in introspection and self-processing. In healthy individuals it exhibits greatest activity during periods of rest, with less activity, observed as deactivation, during cognitive tasks, e.g.
, working memory. This network consists of the medial prefrontal cortex, posterior cingulate cortex/precuneus, lateral parietal cortices and medial temporal regions.
Multiple functional and structural imaging approaches have been developed to study the DMN. These have unprecedented potential to further the understanding of the function and dysfunction of this network. Functional approaches, such as the evaluation of resting state connectivity and task-induced deactivation, have excellent potential to identify targeted neurocognitive and neuroaffective (functional) diagnostic markers and may indicate illness severity and prognosis with increased accuracy or specificity. Structural approaches, such as evaluation of morphometry and connectivity, may provide unique markers of etiology and long-term outcomes. Combined, functional and structural methods provide strong multimodal, complementary and synergistic approaches to develop valid DMN-based imaging phenotypes in stress-related psychiatric conditions. This protocol aims to integrate these methods to investigate DMN structure and function in PTSD, relating findings to illness severity and relevant clinical factors.
Medicine, Issue 89, default mode network, neuroimaging, functional magnetic resonance imaging, diffusion tensor imaging, structural connectivity, functional connectivity, posttraumatic stress disorder
Cortical Source Analysis of High-Density EEG Recordings in Children
Institutions: UCL Institute of Child Health, University College London.
EEG is traditionally described as a neuroimaging technique with high temporal and low spatial resolution. Recent advances in biophysical modelling and signal processing make it possible to exploit information from other imaging modalities like structural MRI that provide high spatial resolution to overcome this constraint1
. This is especially useful for investigations that require high resolution in the temporal as well as spatial domain. In addition, due to the easy application and low cost of EEG recordings, EEG is often the method of choice when working with populations, such as young children, that do not tolerate functional MRI scans well. However, in order to investigate which neural substrates are involved, anatomical information from structural MRI is still needed. Most EEG analysis packages work with standard head models that are based on adult anatomy. The accuracy of these models when used for children is limited2
, because the composition and spatial configuration of head tissues changes dramatically over development3
In the present paper, we provide an overview of our recent work in utilizing head models based on individual structural MRI scans or age specific head models to reconstruct the cortical generators of high density EEG. This article describes how EEG recordings are acquired, processed, and analyzed with pediatric populations at the London Baby Lab, including laboratory setup, task design, EEG preprocessing, MRI processing, and EEG channel level and source analysis.
Behavior, Issue 88, EEG, electroencephalogram, development, source analysis, pediatric, minimum-norm estimation, cognitive neuroscience, event-related potentials
Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats
Institutions: German Heart Institute Berlin, German Heart Institute Berlin, Hamburg, Germany.
Small animal magnetic resonance imaging is an important tool to study cardiac function and changes in myocardial tissue. The high heart rates of small animals (200 to 600 beats/min) have previously limited the role of CMR imaging. Small animal Look-Locker inversion recovery (SALLI) is a T1 mapping sequence for small animals to overcome this problem 1
. T1 maps provide quantitative information about tissue alterations and contrast agent kinetics. It is also possible to detect diffuse myocardial processes such as interstitial fibrosis or edema 1-6
. Furthermore, from a single set of image data, it is possible to examine heart function and myocardial scarring by generating cine and inversion recovery-prepared late gadolinium enhancement-type MR images 1
The presented video shows step-by-step the procedures to perform small animal CMR imaging. Here it is presented with a healthy Sprague-Dawley rat, however naturally it can be extended to different cardiac small animal models.
Medicine, Issue 77, Biomedical Engineering, Anatomy, Physiology, Cardiology, Heart Diseases, Cardiomyopathies, Heart Failure, Diagnostic Imaging, Cardiac Imaging Techniques, Magnetic Resonance Imaging, MRI, Cardiovascular Diseases, small animal imaging, T1 mapping, heart disease, cardiac function, myocardium, rat, animal model
Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking
Institutions: Yale University, Yale University, Yale University, Yale University, Massachusetts General Hospital, University of California, Irvine.
We describe experimental and statistical steps for creating dopamine movies of the brain from dynamic PET data. The movies represent minute-to-minute fluctuations of dopamine induced by smoking a cigarette. The smoker is imaged during a natural smoking experience while other possible confounding effects (such as head motion, expectation, novelty, or aversion to smoking repeatedly) are minimized.
We present the details of our unique analysis. Conventional methods for PET analysis estimate time-invariant kinetic model parameters which cannot capture short-term fluctuations in neurotransmitter release. Our analysis - yielding a dopamine movie - is based on our work with kinetic models and other decomposition techniques that allow for time-varying parameters 1-7
. This aspect of the analysis - temporal-variation - is key to our work. Because our model is also linear in parameters, it is practical, computationally, to apply at the voxel level. The analysis technique is comprised of five main steps: pre-processing, modeling, statistical comparison, masking and visualization. Preprocessing is applied to the PET data with a unique 'HYPR' spatial filter 8
that reduces spatial noise but preserves critical temporal information. Modeling identifies the time-varying function that best describes the dopamine effect on 11
C-raclopride uptake. The statistical step compares the fit of our (lp-ntPET) model 7
to a conventional model 9
. Masking restricts treatment to those voxels best described by the new model. Visualization maps the dopamine function at each voxel to a color scale and produces a dopamine movie. Interim results and sample dopamine movies of cigarette smoking are presented.
Behavior, Issue 78, Neuroscience, Neurobiology, Molecular Biology, Biomedical Engineering, Medicine, Anatomy, Physiology, Image Processing, Computer-Assisted, Receptors, Dopamine, Dopamine, Functional Neuroimaging, Binding, Competitive, mathematical modeling (systems analysis), Neurotransmission, transient, dopamine release, PET, modeling, linear, time-invariant, smoking, F-test, ventral-striatum, clinical techniques
In vivo Imaging of Tumor Angiogenesis using Fluorescence Confocal Videomicroscopy
Institutions: Université Paris Descartes Sorbonne Paris Cité, INSERM UMR-S970, Hôpital Européen Georges Pompidou, Service de Radiologie.
Fibered confocal fluorescence in vivo
imaging with a fiber optic bundle uses the same principle as fluorescent confocal microscopy. It can excite fluorescent in situ
elements through the optical fibers, and then record some of the emitted photons, via
the same optical fibers. The light source is a laser that sends the exciting light through an element within the fiber bundle and as it scans over the sample, recreates an image pixel by pixel. As this scan is very fast, by combining it with dedicated image processing software, images in real time with a frequency of 12 frames/sec can be obtained.
We developed a technique to quantitatively characterize capillary morphology and function, using a confocal fluorescence videomicroscopy device. The first step in our experiment was to record 5 sec movies in the four quadrants of the tumor to visualize the capillary network. All movies were processed using software (ImageCell, Mauna Kea Technology, Paris France) that performs an automated segmentation of vessels around a chosen diameter (10 μm in our case). Thus, we could quantify the 'functional capillary density', which is the ratio between the total vessel area and the total area of the image. This parameter was a surrogate marker for microvascular density, usually measured using pathology tools.
The second step was to record movies of the tumor over 20 min to quantify leakage of the macromolecular contrast agent through the capillary wall into the interstitium. By measuring the ratio of signal intensity in the interstitium over that in the vessels, an 'index leakage' was obtained, acting as a surrogate marker for capillary permeability.
Medicine, Issue 79, Cancer, Biological, Microcirculation, optical imaging devices (design and techniques), Confocal videomicroscopy, microcirculation, capillary leakage, FITC-Dextran, angiogenesis
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Institutions: The Feinstein Institute for Medical Research.
The scaled subprofile model (SSM)1-4
is a multivariate PCA-based algorithm that identifies major sources of variation in patient and control group brain image data while rejecting lesser components (Figure 1
). Applied directly to voxel-by-voxel covariance data of steady-state multimodality images, an entire group image set can be reduced to a few significant linearly independent covariance patterns and corresponding subject scores. Each pattern, termed a group invariant subprofile (GIS), is an orthogonal principal component that represents a spatially distributed network of functionally interrelated brain regions. Large global mean scalar effects that can obscure smaller network-specific contributions are removed by the inherent logarithmic conversion and mean centering of the data2,5,6
. Subjects express each of these patterns to a variable degree represented by a simple scalar score that can correlate with independent clinical or psychometric descriptors7,8
. Using logistic regression analysis of subject scores (i.e.
pattern expression values), linear coefficients can be derived to combine multiple principal components into single disease-related spatial covariance patterns, i.e.
composite networks with improved discrimination of patients from healthy control subjects5,6
. Cross-validation within the derivation set can be performed using bootstrap resampling techniques9
. Forward validation is easily confirmed by direct score evaluation of the derived patterns in prospective datasets10
. Once validated, disease-related patterns can be used to score individual patients with respect to a fixed reference sample, often the set of healthy subjects that was used (with the disease group) in the original pattern derivation11
. These standardized values can in turn be used to assist in differential diagnosis12,13
and to assess disease progression and treatment effects at the network level7,14-16
. We present an example of the application of this methodology to FDG PET data of Parkinson's Disease patients and normal controls using our in-house software to derive a characteristic covariance pattern biomarker of disease.
Medicine, Issue 76, Neurobiology, Neuroscience, Anatomy, Physiology, Molecular Biology, Basal Ganglia Diseases, Parkinsonian Disorders, Parkinson Disease, Movement Disorders, Neurodegenerative Diseases, PCA, SSM, PET, imaging biomarkers, functional brain imaging, multivariate spatial covariance analysis, global normalization, differential diagnosis, PD, brain, imaging, clinical techniques
Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
Institutions: Johns Hopkins University.
Patient-specific simulations of heart (dys)function aimed at personalizing cardiac therapy are hampered by the absence of in vivo
imaging technology for clinically acquiring myocardial fiber orientations. The objective of this project was to develop a methodology to estimate cardiac fiber orientations from in vivo
images of patient heart geometries. An accurate representation of ventricular geometry and fiber orientations was reconstructed, respectively, from high-resolution ex vivo structural magnetic resonance (MR) and diffusion tensor (DT) MR images of a normal human heart, referred to as the atlas. Ventricular geometry of a patient heart was extracted, via
semiautomatic segmentation, from an in vivo
computed tomography (CT) image. Using image transformation algorithms, the atlas ventricular geometry was deformed to match that of the patient. Finally, the deformation field was applied to the atlas fiber orientations to obtain an estimate of patient fiber orientations. The accuracy of the fiber estimates was assessed using six normal and three failing canine hearts. The mean absolute difference between inclination angles of acquired and estimated fiber orientations was 15.4 °. Computational simulations of ventricular activation maps and pseudo-ECGs in sinus rhythm and ventricular tachycardia indicated that there are no significant differences between estimated and acquired fiber orientations at a clinically observable level.The new insights obtained from the project will pave the way for the development of patient-specific models of the heart that can aid physicians in personalized diagnosis and decisions regarding electrophysiological interventions.
Bioengineering, Issue 71, Biomedical Engineering, Medicine, Anatomy, Physiology, Cardiology, Myocytes, Cardiac, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, MRI, Diffusion Magnetic Resonance Imaging, Cardiac Electrophysiology, computerized simulation (general), mathematical modeling (systems analysis), Cardiomyocyte, biomedical image processing, patient-specific modeling, Electrophysiology, simulation
Perceptual and Category Processing of the Uncanny Valley Hypothesis' Dimension of Human Likeness: Some Methodological Issues
Institutions: University of Zurich.
Mori's Uncanny Valley Hypothesis1,2
proposes that the perception of humanlike characters such as robots and, by extension, avatars (computer-generated characters) can evoke negative or positive affect (valence) depending on the object's degree of visual and behavioral realism along a dimension of human likeness
) (Figure 1
). But studies of affective valence of subjective responses to variously realistic non-human characters have produced inconsistent findings 3, 4, 5, 6
. One of a number of reasons for this is that human likeness is not perceived as the hypothesis assumes. While the DHL can be defined following Mori's description as a smooth linear change in the degree of physical humanlike similarity, subjective perception of objects along the DHL can be understood in terms of the psychological effects of categorical perception (CP) 7
. Further behavioral and neuroimaging investigations of category processing and CP along the DHL and of the potential influence of the dimension's underlying category structure on affective experience are needed. This protocol therefore focuses on the DHL and allows examination of CP. Based on the protocol presented in the video as an example, issues surrounding the methodology in the protocol and the use in "uncanny" research of stimuli drawn from morph continua to represent the DHL are discussed in the article that accompanies the video. The use of neuroimaging and morph stimuli to represent the DHL in order to disentangle brain regions neurally responsive to physical human-like similarity from those responsive to category change and category processing is briefly illustrated.
Behavior, Issue 76, Neuroscience, Neurobiology, Molecular Biology, Psychology, Neuropsychology, uncanny valley, functional magnetic resonance imaging, fMRI, categorical perception, virtual reality, avatar, human likeness, Mori, uncanny valley hypothesis, perception, magnetic resonance imaging, MRI, imaging, clinical techniques
Functional Magnetic Resonance Imaging (fMRI) with Auditory Stimulation in Songbirds
Institutions: University of Antwerp.
The neurobiology of birdsong, as a model for human speech, is a pronounced area of research in behavioral neuroscience. Whereas electrophysiology and molecular approaches allow the investigation of either different stimuli on few neurons, or one stimulus in large parts of the brain, blood oxygenation level dependent (BOLD) functional Magnetic Resonance Imaging (fMRI) allows combining both advantages, i.e.
compare the neural activation induced by different stimuli in the entire brain at once. fMRI in songbirds is challenging because of the small size of their brains and because their bones and especially their skull comprise numerous air cavities, inducing important susceptibility artifacts. Gradient-echo (GE) BOLD fMRI has been successfully applied to songbirds 1-5
(for a review, see 6
). These studies focused on the primary and secondary auditory brain areas, which are regions free of susceptibility artifacts. However, because processes of interest may occur beyond these regions, whole brain BOLD fMRI is required using an MRI sequence less susceptible to these artifacts. This can be achieved by using spin-echo (SE) BOLD fMRI 7,8
. In this article, we describe how to use this technique in zebra finches (Taeniopygia guttata
), which are small songbirds with a bodyweight of 15-25 g extensively studied in behavioral neurosciences of birdsong. The main topic of fMRI studies on songbirds is song perception and song learning. The auditory nature of the stimuli combined with the weak BOLD sensitivity of SE (compared to GE) based fMRI sequences makes the implementation of this technique very challenging.
Behavior, Issue 76, Neuroscience, Neurobiology, Molecular Biology, Medicine, Biophysics, Physiology, Anatomy, Functional MRI, fMRI, Magnetic Resonance Imaging, MRI, blood oxygenation level dependent fMRI, BOLD fMRI, Brain, Songbird, zebra finches, Taeniopygia guttata, Auditory Stimulation, stimuli, animal model, imaging
Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
Institutions: German Cancer Research Center, Heidelberg, Germany, German Cancer Research Center, Heidelberg, Germany.
Angiogenesis is an essential feature of cancer growth and metastasis formation. In bone metastasis, angiogenic factors are pivotal for tumor cell proliferation in the bone marrow cavity as well as for interaction of tumor and bone cells resulting in local bone destruction. Our aim was to develop a model of experimental bone metastasis that allows in vivo
assessment of angiogenesis in skeletal lesions using non-invasive imaging techniques.
For this purpose, we injected 105
MDA-MB-231 human breast cancer cells into the superficial epigastric artery, which precludes the growth of metastases in body areas other than the respective hind leg1
. Following 25-30 days after tumor cell inoculation, site-specific bone metastases develop, restricted to the distal femur, proximal tibia and proximal fibula1
. Morphological and functional aspects of angiogenesis can be investigated longitudinally in bone metastases using magnetic resonance imaging (MRI), volumetric computed tomography (VCT) and ultrasound (US).
MRI displays morphologic information on the soft tissue part of bone metastases that is initially confined to the bone marrow cavity and subsequently exceeds cortical bone while progressing. Using dynamic contrast-enhanced MRI (DCE-MRI) functional data including regional blood volume, perfusion and vessel permeability can be obtained and quantified2-4
. Bone destruction is captured in high resolution using morphological VCT imaging. Complementary to MRI findings, osteolytic lesions can be located adjacent to sites of intramedullary tumor growth. After contrast agent application, VCT angiography reveals the macrovessel architecture in bone metastases in high resolution, and DCE-VCT enables insight in the microcirculation of these lesions5,6
. US is applicable to assess morphological and functional features from skeletal lesions due to local osteolysis of cortical bone. Using B-mode and Doppler techniques, structure and perfusion of the soft tissue metastases can be evaluated, respectively. DCE-US allows for real-time imaging of vascularization in bone metastases after injection of microbubbles7
In conclusion, in a model of site-specific breast cancer bone metastases multi-modal imaging techniques including MRI, VCT and US offer complementary information on morphology and functional parameters of angiogenesis in these skeletal lesions.
Cancer Biology, Issue 66, Medicine, Physiology, Physics, bone metastases, animal model, angiogenesis, imaging, magnetic resonance imaging, MRI, volumetric computed tomography, ultrasound
Electron Spin Resonance Micro-imaging of Live Species for Oxygen Mapping
Institutions: The Technion, Israel Institute of Technology.
This protocol describes an electron spin resonance (ESR) micro-imaging method for three-dimensional mapping of oxygen levels in the immediate environment of live cells with micron-scale resolution1
. Oxygen is one of the most important molecules in the cycle of life. It serves as the terminal electron acceptor of oxidative phosphorylation in the mitochondria and is used in the production of reactive oxygen species. Measurements of oxygen are important for the study of mitochondrial and metabolic functions, signaling pathways, effects of various stimuli, membrane permeability, and disease differentiation. Oxygen consumption is therefore an informative marker of cellular metabolism, which is broadly applicable to various biological systems from mitochondria to cells to whole organisms. Due to its importance, many methods have been developed for the measurements of oxygen in live systems. Current attempts to provide high-resolution oxygen imaging are based mainly on optical fluorescence and phosphorescence methods that fail to provide satisfactory results as they employ probes with high photo-toxicity and low oxygen sensitivity. ESR, which measures the signal from exogenous paramagnetic probes in the sample, is known to provide very accurate measurements of oxygen concentration. In a typical case, ESR measurements map the probe's lineshape broadening and/or relaxation-time shortening that are linked directly to the local oxygen concentration. (Oxygen is paramagnetic; therefore, when colliding with the exogenous paramagnetic probe, it shortness its relaxation times.) Traditionally, these types of experiments are carried out with low resolution, millimeter-scale ESR for small animals imaging. Here we show how ESR imaging can also be carried out in the micron-scale for the examination of small live samples. ESR micro-imaging is a relatively new methodology that enables the acquisition of spatially-resolved ESR signals with a resolution approaching 1 micron at room temperature2
. The main aim of this protocol-paper is to show how this new method, along with newly developed oxygen-sensitive probes, can be applied to the mapping of oxygen levels in small live samples. A spatial resolution of ~30 x 30 x 100 μm is demonstrated, with near-micromolar oxygen concentration sensitivity and sub-femtomole absolute oxygen sensitivity per voxel. The use of ESR micro-imaging for oxygen mapping near cells complements the currently available techniques based on micro-electrodes or fluorescence/phosphorescence. Furthermore, with the proper paramagnetic probe, it will also be readily applicable for intracellular oxygen micro-imaging, a capability which other methods find very difficult to achieve.
Cellular Biology, Issue 42, ESR, EPR, Oxygen, Imaging, microscopy, live cells
Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
Institutions: University of Alabama at Birmingham.
Newly emerging theories suggest that the brain does not function as a cohesive unit in autism, and this discordance is reflected in the behavioral symptoms displayed by individuals with autism. While structural neuroimaging findings have provided some insights into brain abnormalities in autism, the consistency of such findings is questionable. Functional neuroimaging, on the other hand, has been more fruitful in this regard because autism is a disorder of dynamic processing and allows examination of communication between cortical networks, which appears to be where the underlying problem occurs in autism. Functional connectivity is defined as the temporal correlation of spatially separate neurological events1. Findings from a number of recent fMRI studies have supported the idea that there is weaker coordination between different parts of the brain that should be working together to accomplish complex social or language problems2,3,4,5,6
. One of the mysteries of autism is the coexistence of deficits in several domains along with relatively intact, sometimes enhanced, abilities. Such complex manifestation of autism calls for a global and comprehensive examination of the disorder at the neural level. A compelling recent account of the brain functioning in autism, the cortical underconnectivity theory,2,7
provides an integrating framework for the neurobiological bases of autism. The cortical underconnectivity theory of autism suggests that any language, social, or psychological function that is dependent on the integration of multiple brain regions is susceptible to disruption as the processing demand increases. In autism, the underfunctioning of integrative circuitry in the brain may cause widespread underconnectivity. In other words, people with autism may interpret information in a piecemeal fashion at the expense of the whole. Since cortical underconnectivity among brain regions, especially the frontal cortex and more posterior areas 3,6
, has now been relatively well established, we can begin to further understand brain connectivity as a critical component of autism symptomatology.
A logical next step in this direction is to examine the anatomical connections that may mediate the functional connections mentioned above. Diffusion Tensor Imaging (DTI) is a relatively novel neuroimaging technique that helps probe the diffusion of water in the brain to infer the integrity of white matter fibers. In this technique, water diffusion in the brain is examined in several directions using diffusion gradients. While functional connectivity provides information about the synchronization of brain activation across different brain areas during a task or during rest, DTI helps in understanding the underlying axonal organization which may facilitate the cross-talk among brain areas. This paper will describe these techniques as valuable tools in understanding the brain in autism and the challenges involved in this line of research.
Medicine, Issue 55, Functional magnetic resonance imaging (fMRI), MRI, Diffusion tensor imaging (DTI), Functional Connectivity, Neuroscience, Developmental disorders, Autism, Fractional Anisotropy
Basics of Multivariate Analysis in Neuroimaging Data
Institutions: Columbia University.
Multivariate analysis techniques for neuroimaging data have recently received increasing attention as they have many attractive features that cannot be easily realized by the more commonly used univariate, voxel-wise, techniques1,5,6,7,8,9
. Multivariate approaches evaluate correlation/covariance of activation across brain regions, rather than proceeding on a voxel-by-voxel basis. Thus, their results can be more easily interpreted as a signature of neural networks. Univariate approaches, on the other hand, cannot directly address interregional correlation in the brain. Multivariate approaches can also result in greater statistical power when compared with univariate techniques, which are forced to employ very stringent corrections for voxel-wise multiple comparisons. Further, multivariate techniques also lend themselves much better to prospective application of results from the analysis of one dataset to entirely new datasets. Multivariate techniques are thus well placed to provide information about mean differences and correlations with behavior, similarly to univariate approaches, with potentially greater statistical power and better reproducibility checks. In contrast to these advantages is the high barrier of entry to the use of multivariate approaches, preventing more widespread application in the community. To the neuroscientist becoming familiar with multivariate analysis techniques, an initial survey of the field might present a bewildering variety of approaches that, although algorithmically similar, are presented with different emphases, typically by people with mathematics backgrounds. We believe that multivariate analysis techniques have sufficient potential to warrant better dissemination. Researchers should be able to employ them in an informed and accessible manner. The current article is an attempt at a didactic introduction of multivariate techniques for the novice. A conceptual introduction is followed with a very simple application to a diagnostic data set from the Alzheimer s Disease Neuroimaging Initiative (ADNI), clearly demonstrating the superior performance of the multivariate approach.
JoVE Neuroscience, Issue 41, fMRI, PET, multivariate analysis, cognitive neuroscience, clinical neuroscience

domain: medical


text:
A mother hugged by her children,..
cute ladybug holding red flower..
Small baby hand offering a white..
Pastel roses collage mother s day..
hearts and card with close spins..
Purple floral border with copy..
two valentines day heart on wooden..
red tulips, candles and label
A Beautiful Tuberose Flowers Arranged..
Multi coloured balloons, confetti..
Pastel roses mother s day card
label with lettering thanks and..
red heart on wooden board
red tulips and card with lettering..
Composition with tulips and gift..
Decoration on Wooden background..
Surprise Mom - flower from a daughter..
violet loop, hearts and card on..

domain: artistic


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Great music it sounds modern kind of a hip hop with a "Peppers" guitar tone.
Quite a selection Music! right on !
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Thought Michael Bamboo Stripe Boxers
Thought »Product code: M429544
Earn 75 reward points on this item In Stock : Available for despatch today Gift wrap available
Soft and sustainable bamboo and organic cotton boxers from Thought, ethically made with added stretch for comfort. The bamboo boxer briefs are made with Oeko-Tex standard 100 certified fabric and suitable for vegans.
The Michael boxers are made with a blend of bamboo and organic cotton. Bamboo is an extremely sustainable material, growing incredibly fast and with minimal resources, and Thought uses a chemical closed loop method to produce bamboo fabric, which ensures no chemicals escape the process into the environment. The non-GM organic cotton used is certified by the Global Organic Textile Standard, and no harsh chemical pesticides or fertilisers are used to grow the cotton, which is much better for the soil and much safer for farmers.
Thought work closely with their factories in China to ensure products are made to the highest ethical standards. Today they still work with the first factories they did when the company was founded, and continue to create long term partnerships. Thought has a strict code of conduct policy their suppliers must follow, and ensure the conditions are always being met.
67% viscose derived from bamboo, 28% GOTS certified organic cotton, 5% spandex Jersey.
Ethically made in China
Please note: Due to hygiene reasons we are unable to accept returns of underwear for exchange or refund.
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They work with some of the same factories they did when they first started and believe in growing business together. People and partners are important to them – they have a Code of Conduct and other policies that put them first. Everyone employed by Thought is treated with respect, paid a fair wage and free from any kind of discrimination – it really is a brand with a conscience.
Please see our Despatch & Delivery page for more information on delivery areas, services and charges.


text:
Sebi’s Derivatives Market Review Committee has recommended the introduction of mini contracts in equity indices, options with longer tenures, a volatility index and exchange-traded currency contracts.
The mini proposed by the committee will be a fraction of the normal derivative contract, and would be affordable for individual investors who want to hedge their positions in the market.
The committee has also proposed long-term option contracts with maturity of up to five years. Currently, option contracts in India carry a three-month maturity cycle.
Click here to view the interim recommendations of the committee headed by Prof M. Rammohan Rao.

domain: economics


text:
Wyoming’s congressional delegation should drop its opposition to sending the Bells of Balangiga back to Philippines, and in doing so enable long overdue healing.
F.E. Warren Air Force Base
The cavalry came to the rescue and ended the Johnson County Cattle War on this date in 1892.
Wyoming's U.S. Rep. Liz Cheney cheers as Trump tweets the world to the brink of nuclear war.
The U.S. Air Force provided a rare look into a launch control center for a Minuteman III nuclear missile during an ICBM test conducted earlier this month.
Newly-appointed Sen. Brian Boner (R-Douglas) was a launch officer who held the keys to fifty missiles while stationed in an underground control center.


text:
Harraton CottageDistance from the centre of Kingsbridge: 6.4 miles
Harraton Cottage is the perfect rural retreat, it is placed firmly in the heart of the countryside, but is within easy reach of many beaches, the South West Coastal path and Dartmoor.
Our enviable location means there are plenty of great activities and days out close by. The cottage is easily accessible – just 15 minutes from the A38, 10 minutes to the award-winning Bantham surfing beach and 2 miles to the beautiful town of Modbury.
Harraton Cottage is furnished to a very high standard and is fully equipped for all your needs, it combines countryside living with modern facilities.
AT A GLANCE:
- Ideal for families or groups of friends
- Four bedrooms sleeping ten people
- 2 x king size rooms, 1 x twin room and 1 x room with 2 bunk beds
- 2 x en-suite bathrooms and 1 x family bathroom
- Open-plan living/kitchen/dining area
- TV Snug
- Underfloor heating downstairs and 2 woodburners
- Patio set with fire pit and Gas BBQ
- Utility room
- Well behaved dogs welcome
- Front lawn and rear paddock with tyre swing.
- A wide range of baby and toddler equipment available

domain: travel


text:
Hulhumale' Hospital has an ongoing development project- which plans to establish a mental health centre in the hospital by October 2022. The hospital, which has been working a Consultant since July 2022, has recognized the growing demand for and scarcity of mental health services in the Maldives and has been working on establishing a mental health centre within the hospital, with the goal of having the centre open by October 10th in celebration of world mental health day.
The Maldives, like many Asian countries, has a taboo against discussing mental health. Despite the fact that a significant number of Maldivians suffer from mental illnesses, these issues are usually discussed behind closed doors or simply locked away, never to be discussed again. Due to the stigma surrounding mental health, getting help can be extremely difficult in the Maldives.
Even with an established mental health centre in the Government-run hospital Indira Gandhi Memorial Hospital (IGMH), the wait-list can put you on hold for weeks or even months. In addition to this, the medication for mental health issues usually not falling under the Aasandha insurance scheme means that one has to bear a hefty bill at the end of their visit.
The wait-lists for mental healthcare have made it quite evident that the demand for the services is not being met, leaving many to suffer in silence without getting help on time.
While there are ways to get help, regardless of the cost or the length of the line when it comes to people who reside in the capital city Male’, there are no options for those living on local islands. Since this issue has been completely ignored, people in the atolls have two options if they ever need treatment or even a diagnosis: wait for a visiting doctor or travel to Male' to get help.
The difficulty is further piled on, due to the stigma surrounding the topic as the issue might be brushed off and dismissed as something that is ‘just in your head’.
With the mental health services availability this scarce and pricey, establishment of more mental health centres has become extremely important.


text:
WASHINGTON – Members of the House Science, Space, and Technology Committee praised last night’s House passage of the Solar Fuels Innovation Act (H.R. 5638) and the Electricity Storage Innovation Act (H.R. 5640) that were favorably reported out of committee by voice vote last week. Both bills are part of Majority Leader Kevin McCarthy’s (R-Calif.) Innovation Initiative.
Chairman Lamar Smith (R-Texas): “The passage of H.R. 5640 takes us one step closer to a more robust energy sector. Electricity storage is one of the next frontiers in our energy future. Innovations leading to advanced, next generation batteries could help bring affordable electricity and renewable energy to the market without costly subsidies or mandates.
“The transformative breakthroughs in energy science achieved by researchers at our national labs will empower the private sector to develop innovative electricity storage technologies. The private sector is best suited to bring new battery technology to the commercial energy market. I want to thank my colleagues on the Science Committee for their bipartisan support of this important basic research initiative, and I look forward to working with our colleagues in the Senate to move this bill to the president’s desk.”
The Electricity Storage Innovation Act, introduced by full Committee Chairman Lamar Smith (R-Texas), authorizes the Secretary of Energy to carry out a $100 million basic research initiative in the chemistry and materials sciences necessary for advanced electricity storage systems. H.R. 5640 directs the Department of Energy to also conduct this research using existing funds in the DOE Office of Science and EERE.
Rep. Stephen Knight (R-Calif.): “I applaud the passage of H.R. 5638. Basic research in artificial photosynthesis and related research could lead to a solar fuels system that consolidates solar power and energy storage into a cohesive process and fundamentally change the way we extract energy from our natural resources.
“Scientists up and down the coast of California are undertaking this research, from universities in Southern California to Lawrence Berkeley Lab in the Bay Area. The research authorized in this legislation could solve this key scientific challenge, and open the door for American entrepreneurs to develop the next generation of solar technology.
“I’d like to thank my colleagues who joined me in introducing this bill and the many research institutions that offered letters of support. I look forward to its introduction in the Senate.”
The Solar Fuels Innovation Act, introduced by Energy Subcommittee Vice Chairman Stephen Knight (R-Calif.), authorizes the Secretary of Energy to carry out a $100 million basic research initiative to foster scientific discovery in advanced chemistry for the eventual development of solar fuels systems. The process of creating fuels from the sun, also known as artificial photosynthesis and photosynthesis replication, relies heavily on the fundamental study of chemistry and materials science by the DOE Office of Science. This legislation also authorizes translational research in solar fuels, focusing the DOE Office of Energy Efficiency and Renewable Energy (EERE) on early-stage R&D that will not be undertaken by the private sector, and provides accountability to ensure limited federal research funds are used responsibly. H.R. 5638 directs the Department of Energy to conduct this research using existing funds in the DOE Office of Science and EERE.


text:
Ending today, Macy's
takes an extra 10% to 15% off
select items via coupon code "HOME" during its Home Sale
. That's tied with yesterday's mention (which was due to expire) and among the best sales we've seen from Macy's in recent weeks. (We saw the same offer sitewide three days ago, since expired.) Shipping starts at $9.95
, but orders over $99 (after discount) qualify for free shipping. Sales tax is added where applicable and some exclusions apply.


text:
Building on last year’s success, which attracted 129 delegates, we are partnering with Freedom Festival for the second time to bring our International Showcase to the former UK City of Culture.
Taking place from 30 August – 1st September, Freedom Festival is a blend of theatre, music, comedy, poetry, outdoor spectacle and performance aimed at a wide audience of all ages, bringing renowned national and international artists to Hull while providing significant opportunities for local and regional talent. Born out of the William Wilberforce commemorations in 2007, which celebrated the bicentenary of the abolition of the slave trade led by Hull’s most famous son, the annual Freedom Festival has evolved into one of the UK’s most distinctive international arts festivals. A commitment to presenting impactful work which explores themes of freedom such as, democracy, equality and protest set it apart from other comparable festivals, celebrating the city’s unique history whilst also engaging in a global conversation around human rights.
We invite you to spend three days in the context of this ambitious festival and see a rich programme of outdoor shows, learn about new models of working and meet with others working in the industry in a professional programme that will include talks, networking and pitching sessions.
What to expect
- A programme of +30 world-class UK and international shows
- 6 Without Walls 2019 Commissions
- Large-scale Nighttime shows
- Community projects
- Full programme to be announced soon.
Professionals programme – a sneak preview
With details to be confirmed, you can expect another high-calibre event including….
- Panel discussions
- A Festival launch event
- XTRAX Shorts
- Formal and informal networking opportunities
The XTRAX / Freedom Festival 2019 Showcase is supported by Arts Council England through National Lottery Project Grants


text:
A consortium has presented proposals to build Abuja Medical City, a $650 million (N100 billion) multi-hospital complex for 1,687 beds, in the heart of the federal capital.
The AMC will include seven hospital areas, facilities and residences on 121,285 square metres of land along Lugbe Road-between Abuja airport and the city, an area twice the size of the National Assembly complex and six times the National Stadium, according to consortium Ceinsa, which includes firms IBT, KMD Architects and Sucomex.
Details of the contractor-financed project were revealed in a presentation Ceinsa made to the Health Minister Onyebuchi Chukwu in Abuja.
Ceinsa also projects AMC could benefit more than two million Nigerians and help redirect more than $500 million dollars lost to medical tourism back into Nigeria, according to Daniel Toledano of IBT/Ceinsa.
Ceinsa chairman Dumebi Kachikwu said the contractor-financed project could be completed in 24 months and begin operations in the final six months.Chukwu said the turn-key project "fits in with the concept" of new designed city to mark the 100th anniversary of Nigeria's amalgamation. But he insisted government would be open to "competitive bidding," going by government procurement process.

domain: politics


text:
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Under the law, the MGCB was granted the power to issue licenses for online and mobile casino gambling. Michigan’s sports wagering market went live on March 11 with the opening of sportsbooks at Penn National Gaming’s Greektown Casino and the MGM Grand Detroit. Online and mobile sports wagering has yet to go live in the state of Michigan.
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domain: entertainment


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In 1967, the Soviet Mil V-12 helicopter made its first lift-off successfully. The US military had an urge to match or top this heavy-lift helicopter. In early 1970, a joint Army and Navy working committee was formed to study the development of a heavy lift helicopter. The requirement for a 22-ton payload class HLH was issued. Boeing proposed the tandem-rotor Model 301 that was about twice size of the Chinook. Other design included in the competition was the Sikorsky S-73. In 1973, a contract was awarded to Boeing for the construction of one prototype, designated XCH-62. In 1975, the XCH-62 prototype had been 90% complete, being readied for a planned initial flight the next year, but Congress declined to provide further funding. The incomplete XCH-62 program was terminated. In 1983, the Army and NASA proposed collaboration to finish the aircraft for experimental flights but Congress again refused to fund the project. The XCH-62 remained in storage until 1987 when it was decided that it should be placed in the US Army Aviation Museum at Fort Rucker, Alabama


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It will soon be more convenient to travel between India and the Asia Pacific region, following the formation of a new partnership between two airlines.
India’s Jet Airways and Singapore-based Jetstar Asia have announced plans for a codeshare agreement that will create a series of new travel opportunities between India and multiple Asian and Australian destinations, via Singapore.
Jet will place its 9W flight code on Jetstar’s flights operating from Singapore to 11 destinations: Bangkok, Phuket, Perth, Darwin, Jakarta, Bali, Surabaya, Ho Chi Minh City, Kuala Lumpur, Penang and Hong Kong. Three of these – Darwin, Phuket and Penang – will be entirely new destinations for the Indian carrier.
These services will connect at Singapore’s Changi Airport with Jet’s services to and from four Indian cities: Mumbai, Delhi, Chennai and Bengaluru.
“Jetstar Asia flies to some of the most popular leisure and business destinations across the Asia Pacific. With this codeshare agreement, our guests will now be able to conveniently tap into this extensive network to explore new and exotic destinations… via Singapore,” said Jayaraj Shanmugam, Jet’s chief commercial officer.
This marks the latest codeshare partnership aiming to improve travel between Asia Pacific and India via Singapore; recently, Singapore Airlines and SilkAir agreed to codeshare with SIA’s Delhi-based subsidiary, Vistara.


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CERGU Welcomes Maja Hultman!
Maja Hultman is a new CERGU postdoc.
CERGU welcomes a new postdoc, Maja Hultman, who officially started on January 1, 2021. Maja's home department is the Department for Historical Studies, and she received her PhD in 2019 from the University of Southhampton.
Here is a brief description of Maja's postdoc-project plan: Retracing the transnational movements of two Swedish-Jewish business families, and their subsequent migration of cultural ideas between diasporas and across national borders, the project The Impact of the Shoah on European-Jewish Business Networks and Cultural Mobility examines the function, disappearance and/or change of Jewish cultural centres in Europe, influencing Swedish-Jewish life, from the 1910s to the 1970s. It studies the period before, during, and after the Shoah , and thus examines the impact of Christendomʹs antisemitism –annihilating six million Jewish souls and European-Jewish cultural centres in the 1940s – on Jewish belonging to Europe. With an interdisciplinary approach – using business history, cultural studies, comparative studies, and gender studies – the project shows how firstly, European Jews used transnational structures to collaborate on cultural developments, and secondly, discriminating jurisdiction against an ethnic minority within one European nation potentially informs the ethnic group’s cultural practices in other parts of Europe.

domain: sociology


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Steerner, an artist with some very impressive streams on Spotify, has just released a new track. “Nowhere” comes out through Universal Music Sweden and sounds gorgeous.
In his feel-good style of production, Steerner ensures that he doesn’t miss a trick with this release – which has a wonderful balance of vocal and instrumental elements.
Steerner says: “Nowhere’ is a track that is a bit different from what I’m use to make and I’m very happy how it turned out. I couldn’t be happier to release it through UMG! Looking forward to seeing the reactions to this one!”
Take a listen here.


We have own factory for CPLA cutlery and trade for paper cup,corn starch tableware.
Our CPLA cutlery is BPI,EN13432,FDA,BPA FREE,SGS certified.
1. What is your MOQ?
100,000pcs/size/design,Lower MOQ for trial is acceptable.
2. How can we get the samples?
Sample is free for you.But the freight is paid by buyer.
3. Do you accept customized orders?
Sure,we can provide OEM and ODM as well.
4. What are the payment item?
T/T 100% for small order.T/T 30% in advance and 70% by the copy of B/L for normal orderBiodegradable Cup suppliers
Xiamen Fushide Packing Machinery Co., Ltd Xiamen FUSHIDE was established in 1998, an industrial company which is specialized in R&D, Design, Manufacture and Sales. Producing multiple series of packing equipment machinery. "Quality win reputation,…
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Our History Foshan Nanhai Meijing Machinery Manufacture Co., Ltd. established in 2005. We are engaged in manufacturing and suppling of tissue paper converting machinery. Adhere in researching & developing series of toilet roll/kitchen towel rewinder,…
★An Introduction to Wuhan HealthCare Biotechnology Co., Ltd. Wuhan HealthCare Biotechnology Co., Ltd. is a fast growing National High Tech Enterprise (NHTE) and a leading manufacturer engaged in the design, research, development, production and marketing…
D-180Y4 filling and packing machine V-shape former is one of the forms of flat sheet single-film pair former, which is composed of V-notched guide plate, guide roller and double-track longitudinal sealing roller. It is suitable for forming flat bags with…


Tazza Kitchen cooks up plans for Scott’s Addition
RICHMOND, Va. — Scott’s Addition’s recent growth spurt has been fueled by apartments, office space and breweries. Now here come the restaurants.
Local restaurant brand Tazza Kitchen has preliminary plans to occupy about 3,800 square feet in the 106,000-square-foot building at 1500 Roseneath Road, confirmed John Haggai, one of the co-founders of the regional chain.
“The location most definitely fits our vibe,” Haggai said of Scott’s Addition. “Given what’s going on, we’d like to be down there.”
Haggai emphasized the plans are “very preliminary,” and are contingent upon city council’s approval – a measure that may occur in January 2017.
Thalhimer Realty Partners, the development arm of local real estate firm Cushman & Wakefield | Thalhimer, bought 1500 Roseneath Road in March for $4.12 million. The building covers nearly an entire city block in Scott’s Addition and is bounded by Roseneath Road, and Moore and West Leigh streets.


text: At the beginning of March 2019 the latest album of Coma will be released. At the beginning of March 2019 will be released the latest album of Coma entitled Sen o Siedmiu Szklankach. It is an album with covers inspired by the band’s outdoor concert experiences in 2018, where the band experimented with arranging songs from films for children. The discovery of unobvious, psychedelic and dark contexts in songs from e.g. Pana Kleks, convinced the band to expose the oddity and universal message of the songs by passing them through the rock mangle of Coma and creating over an hour long, hard, slightly nostalgic and trance concert supplemented with visualizations from films. The spring tour with this material has been named Witajcie w naszej bajce. During the concerts, apart from the set with songs such as Meluzyna,Z Poradnika Młodego Zielarza,Pi i Sigma (Przybysze z Matplanety),Fantazja,Pożegnanie z Bajką,Ratujmy Kosmos,Czemu Nas Tam Nie Ma and others, you will also hear the traditional repertoire of the band.


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TexplainerMore in this series
Hey, Texplainer: What did they do to the dome during the restoration that makes it look so shiny and different from the rest of the building?
Last summer, the State Preservation Board decided to restore the Capitol's dome, which was leaking and its color fading. They put up scaffolding in June 2010, repaired the dome and repainted around its 96 windows in about six months. It was the first restoration of the 75,000-square-foot dome since a two-year project that began in 1991. The most recent restoration required 1,200 gallons of paint.
Turns out, it's all that fresh paint that makes the dome look so different from before and from the rest of the granite building. The paint gives the metal dome more color and gloss. But it will fade with age and eventually return to the less putty-like visage we're all used to.
Got a question for Texplainer? E-mail us at email@example.com.


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30 September 2015 4By Jared DiPaneSamsung and Photobucket have partnered to bring an exclusive Photobucket for Samsung app that will allow users to easily store, manage and print their photos. As an incentive, Samsung customers will get 6 months of unlimited storage for free.
28 September 2015 28By John CallahamSamsung has revealed it will shut down its Milk Video app after November 20. The app launched in November 2014 and was designed to be a way for users to find and share popular online video clips.
26 September 2015 112By Jared DiPaneSamsung has announced a new offer to entice users to switch from their current smartphone to a new Samsung smartphone. The company is offering to pay your monthly phone payments until 2016, and iPhone users will get an extra $100 in Google Play credit.
Home Automation has been one of the largest and fastest-growing segments of the tech industry in recent years. New products are constantly being released to make our homes more secure, more convenient, and more efficient than ever before...
Portions of this page are modifications based on work created and shared by the Android Open Source Project
and used according to terms described in the Creative Commons 2.5 Attribution License. AndroidCentral is an independent site
that is not affiliated with or endorsed by Google.


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Fiber filaments are all plastic particles that are melted and drawn at high temperature. They are industrial products and are basically standardized products. The focus of fiber yarn is mainly reflected in: plastic particles, drawing process and curvature, oxidation peak, dyeing process, curvature and curvature ratio. Many names such as bionic wool on the market are essentially fiber filaments.
Plastic pellets: raw materials that can be drawn, PBT and PET, PET is often used as cling film, etc. PET is softer, and PBT has better toughness and strength. These two raw materials are both domestically produced and imported. Imports generally use BASF's pellets, but I have heard that better raw materials come from Mitsui and Mitsubishi, and basically only Japanese brands are useful. Generally, it’s good if you can use BASF. The editor is very responsible to tell everyone that if the brush you buy is not at the price, there is a high probability that you will not use BASF’s raw materials. Basically, you can use Yanshan Petrochemical and Yizheng Petrochemical's is pretty good. The price of fiber yarn is only reflected in the raw materials, and the others are to increase the degree of comfort, such as the texture is more skin-friendly.
Wire drawing process: The wire drawing process is mainly reflected in the uniformity of wire thickness, toughness and tensile strength. In this regard, the differences between manufacturers are not very big. The big difference is that good factories have quality assurance in the use of materials. With the same process, the silk effect of good materials will definitely be better. Furthermore, the curvature is produced during the drawing process. The curvature is to imitate the animal hair in reality. We found that the animal hair is not very straight. In addition, the animal hair has hair scales, which is better for sticking powder; and the fiber silk has no hair scale structure, so it can only be obtained by curvature The effect of sticking powder is not that the greater the curvature, the better, but that there is an applicable standard.
Oxidation of peaks: Generally speaking, after the filaments are cut to a specific required length, they need to be corroded by sodium hydroxide solution to obtain fiber filaments with peaks. Factors such as temperature, dosage, and time have a great influence on peak output. Undesirable conditions such as bending, peak breaking, uneven thickness of the upper and lower sides are common conditions that affect the experience of use. We have also heard of the so-called machine polishing peak. As for this technology, the editor just wants to say that this is a concept, and the current hype is mostly.
Dyeing process: This is very important and is related to the aesthetics of the fiber. Some people say what dyeing materials are used, pollution-free, pure plants, consumers should think about it, pure plants are difficult to dye, or it is difficult to maintain a fixed color, and how to fix the color, you have to use chemicals raw material. Just like people wear clothes, except for cotton and other natural materials, they are basically chemical fiber clothes, which are basically dyed. There is almost no problem with the current level of technology, but if you pay a premium to buy expensive clothes, consumers may be able to wear it more comfortably.
Curvature and curvature ratio: The curvature is formed during wire drawing, and the curvature ratio is the most suitable and most comfortable bristle solution obtained after many tests. The matching test is generally tested by the big-name cosmetic brush brands to guide the manufacturer. Many cosmetic brush manufacturers only know that they are produced for the production of cosmetic brushes, but do not know that the bristles have a curvature ratio.

domain: chemistry


According to a series of news agencies, the 2013 Chevrolet Silverado 1500 Hybrid has been unveiled and now, experts are reviewing it.
The reports show that the 2013 Chevy Silverado 1500 Hybrid offers a considerably high gas mileage if you consider a large-sized truck, however, it may not be the extra cost for the hybrid technology. According to one account, this model offers limited options. When it comes to power delivery, it may feel somewhat unconventional, however, this model can accelerate to almost 30 mph on electric power alone.
Experts say that while this vehicle may have a questionable value, it could be useful for drivers willing to pay extra for the hybrid option. California motorists looking for a large truck with great city gas mileage may find this model a great option.
If you’re tired dealing with lemons and you would like to learn more about this vehicle, click here for the full review and report on this model’s specifications. Also, learn more about what experts found out during tests.