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Although we might shudder at the thought of billions of bacteria living in our lower intestine, we are colonized by these passengers shortly after birth. However, the relationship is mostly of mutual benefit, and they shape our immune system throughout life. Here, we describe our developing understanding of the far-reaching effects that the commensal flora have on mucosal and systemic immunity and their relevance to the effects of hygiene on human disease.
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The authors declare no competing financial interests.
A family of proteins exhibiting bactericidal properties. They are secreted by immune cells (particularly neutrophils), intestinal Paneth cells and epithelial cells.
Non-responsiveness of the immune system resulting from the deletion of specific thymocytes (central tolerance) and the deletion or functional inactivation of specific T cells in the periphery (peripheral tolerance) in the presence of large quantities of antigen.
Non-responsiveness of the immune system in the presence of a given antigen, despite the existence of specific T and B cells capable of mounting a functional response.
- INFLAMMATORY BOWEL DISEASE
Immune-mediated inflammation of the bowel. There are two main forms: Crohn's disease, which is a granulomatous segmental inflammation affecting any part of the intestine, and ulcerative colitis, which is a mucosal inflammation involving the rectum and extending for a variable distance along the colon. In developed countries, the incidence of inflammatory bowel disease is approximately 1 in 50,000. It usually starts in early adult life and continues afterwards with a relapsing, remitting course.
- LAMINA PROPRIA
The layer of the intestine between the epithelial cells and the most superficial smooth-muscle layer.
Resemblance between epitopes contained within microbial and host proteins, leading to crossreactivity of T cells in the host.
The relationship between two different species that live in close proximity and benefit from one another.
- PEYER'S PATCHES
Collections of lymphoid tissue located in the mucosa of the small intestine, with an outer epithelial layer containing specialized epithelial cells, called M cells.
The spectrum of B or T cells. Defined according to the specificities of the B-cell- or T-cell-receptors that are present immediately before onset of a clinically important infection.
- T-CELL-DEPENDENT ANTIGEN
To generate an antibody response to a T-cell-dependent protein antigen requires recognition of the antigen (in the context of MHC molecules) by helper T cells and cooperation between those antigen-specific T cells and B cells that recognize the same antigen.
- TOLL-LIKE RECEPTORS
Cell-associated pattern-recognition receptors that recognize molecules unique to microorganisms, resulting in immune-cell activation and production of pro-inflammatory molecules.
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Macpherson, A., Harris, N. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 4, 478–485 (2004). https://doi.org/10.1038/nri1373
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A sterling silver heart-shaped pendant frames a lovely rose with a sparkling rhinestone crystal at the center of the flower. Personalize your jewelry with the crystal color of your birth-month! Available in all 12 birth month colors. Sterling silver chain included. Photo enlarged to show details.
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Previously, we identified plasmatocyte spreading peptide (PSP1) from the moth Pseudoplusia includens and reported that it induced plasmatocytes to rapidly spread on foreign surfaces. Because of dependence among members of a population, the problem of determining threshold conditions was approached by systematically embedding a system of differential equations in a stochastic process and determining if the Jacobian matrix of this system is stable or not stable, when evaluated at a disease free equilibrium. The method developed here leads to a coupled system of nonlinear ordinary differential equations for the oxygen concentration in the capillaries, and is easy to apply even for vascular beds containing a large number of capillaries. By using the X-ray crystallographic method, four crystal structures of Aspergillus fumigatus phytase were obtained at resolution higher than 1.7 A. Ror2 is a receptor tyrosine kinase, the expression of which increases during differentiation of pluripotent stem cells to osteoblasts and then declines as cells progress to osteocytes. Prolonged hyperuricemia is associated with the development of glomerulosclerosis in the rat. Microhematuria is probably one of the most sought for clinical signs of urinary diseases. The role of recombination and mutation in 16S-23S rDNA spacer rearrangements.
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Further studies demonstrated that the strain was a moderately halophilic bacterium and capable of degrading benzoic acid, 2-nitrophenol, 2-aminophenol, 4-hydroxybenzoic acid, and 4-dimetylaminobenzaldehyde. The dynamic viscoelasticity of designer SAP solutions was examined during titration with different alkaline reagents. We analyzed data reported in the scientific literature to assess how the program for medicalizing information systems employed in France for budget management and allocation could be used to evaluate health care quality. Activation of ASICs in the medulla also triggered neuronal excitation. Bromocryptine induced a slight dose-dependent decrease of sGnRH-induced release of LH. The presence of BSA resulted in partial disassembly of PEI-DNA particles, but acidic pH did not affect particle stability. Several molecular mechanisms regulate these diverse DC functions, and we have previously reported that mouse dendritic cells (mDCs) can produce interleukin-2 (IL-2) in vitro and in vivo, in response to microbial activation and T-cell-mediated stimuli. The histologic differentiation of these lesions was, however, subjective and quite unreliable. We investigated the influence of nonylphenol (NP), bisphenol-A (BPA), and 17beta-estradiol (E2) on developing Xenopus laevis embryos, as a model animal in the aquatic environment. However, the rate of bacterial killing for aminoglycosides is also a concentration-dependent phenomenon.
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On the certification of cadmium at trace and ultratrace levels in standard reference materials using ID ICP-MS. Etiology of Neuromuscular Fatigue After Repeated Sprints Depends on Exercise Modality. We report a case of an isolated right lumbar arterial bleeding after radical nephrectomy for renal infarction with infected perirenal haematoma. Use of iodine-123 metaiodobenzylguanidine scintigraphy to assess cardiac sympathetic denervation and the impact of hypertension in patients with non-insulin-dependent diabetes mellitus. Because of surface activity of carriers used, complete dissolution of drug from such solid dispersions can be obtained without the need for pulverization, sieving, mixing with excipients, etc. The undertaken investigations show that the newly derived OPLS-AA-SEI force field will allow simulating larger carbohydrates or polysaccharides with improved sampling of the hydroxyl groups. Traditional Chinese medicine usage among schizophrenia patients. The occurrence of the 8 Hz tremor was much more related to the feeling of unsteadiness than the 16 Hz tremor. This case demonstrates that a hippocampal epileptic focus causing electrographic focal status epilepticus may be limited to a volume of less than 1 cm in diameter.
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Expression of members of Wnt and Frizzled gene families in the postnatal rat cochlea. The maintenance of extracellular matrix structural and biological integrity is important, and here we describe the assessment of these properties using immunostaining for extracellular matrix proteins and ELISA for growth factor quantification. Regional strain analysis using echocardiographic speckle tracking radial strain strongly correlated with strain by angle-corrected TD imaging in an animal model of dyssynchrony. Further, these BM-derived SP/Mac-1(low) cells gave rise to mononucleate myocytes, indicating that their myogenesis was not caused by stochastic fusion with host myogenic cells, although they required cell-to-cell contact with myogenic cells for muscle differentiation. Accordingly, the striking similarities between the human and mouse nm23 genes enable the use of mouse transgenic and knock-out models for studying the role of nucleoside diphosphate kinase isoforms in human physiopathology. A surgeon can operate or approach a complicated integral calculus instead of a renal one: implications for conceptual and lexical semantic disambiguation. This review highlights the principal underlying factors for metabolic disorders in these chronic viral diseases-namely insulin resistance and liver damage. Wollaston, who first described cystine stones, as well as the most outstanding contemporary figures and their contribution to the understanding of this uncommon type of lithiasis are described. Hormonal therapy plays an integral role in the management of the majority of women with breast cancer who can be considered to have hormone-dependent breast cancer because of the presence of the molecular predictive markers, estrogen receptor and progesterone receptor.
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The spectrometer is capable of measuring absolute spectral emissions at 165 nm wavelength as small as 5x10(-7) J/nm from a plasma source area of 0.37 mm(2) and with 0.4 ns time resolution. The in vivo function of PTEN/MMAC1 appears to be dephosphorylation of phosphotidylinositol 3,4, 5-triphosphate. Principles of laser-tissue interactions in the eye are reviewed. The presence of upper harmonics is clearly evident at the location of a malignant lesion within a mastectomy. Lymph node metastasis in the hepatoduodenal ligament is known as one of the most significant prognostic factors after liver resection for colorectal metastasis. Color Doppler ultrasonography might be valuable in determining the efficacy of antibiotic therapy and justifying the need for operation. HBV can invade acinar cells of pancreas and islet cells, which might be a direct cause of insulin-dependent diabetes mellitus-like the disorder and insulin absence after HBV infection. It also provides evidence that variations in TCF7L2 may play a crucial role in the pathogenesis of type 2 diabetes by influencing both insulin secretion and insulin resistance.
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Unlike the common NO reductases, the enzyme consists of a single subunit of 75 kDa which contains both high-spin and low-spin heme b, but lacks heme c. An exogenous substance is defined as an endocrine disrupter chemical (EDC) if it alters the function of the endocrine system provoking adverse health effects. PVI using traditional point by point radiofrequency ablation is time consuming and technically challenging. The ascent of the spermatozoa of boar in the genital tract of the sow in estrus. Here, experiments in vivo and in vitro demonstrate that Akr1p, a polytopic membrane protein containing a DHHC cysteine-rich domain (CRD), is a palmitoyl transferase (PTase). As ions exit the drift tube, they can be subjected to collisional activation to produce fragments prior to being introduced into a mass spectrometer for detection. The production, characterization and in vivo properties of a new mouse anti-rat IL 2 receptor mAb that reacts with an epitope different to the one that binds to IL 2 and the mAb ART-18.
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On the basis of these findings, we no longer screen asymptomatic patients for deep venous thrombosis following hip and knee replacement, and all patients receive warfarin anticoagulation for two weeks. Clearance of the heavy and light polypeptide chains of human tissue-type plasminogen activator in rats. Clinicopathological factors were compared between patients who developed SSI and those without it. Relationships between income, subjective health and caregiver burden in caregivers of people with dementia in group living care: a cross-sectional community-based study. Stereoselective Meerwein-Ponndorf-Verley (MVP) reductions, including intermolecular MPV reductions, intramolecular MPV reductions (asymmetric 1,5- and 1,7-hydride shifts), catalytic MPV reduction, and reactions related to the MPV reduction are reviewed from the standpoint of asymmetric synthesis. Lesions of the FX and MP were also protective against PTZ seizures but to a lesser degree than the MT lesions.
Nine of these patients with active native valve endocarditis required emergency surgery. Gene therapy has the potential to provide cancer treatments based on novel mechanisms of action with potentially low toxicities. This paper includes a brief discussion about how nonpositive concentrations arise from numerical solution of the convection and cross-dispersion terms. However, the cold-responsive genes lip5, lip9, and OsDhn1 were up-regulated in the transgenic plants, suggesting that the cold signal transduction pathway involving CBF1 is partially conserved in this cold-labile plant. ARB dosage optimization or the addition of a second renoprotective agent (ACE inhibitor or non-dihydropyridine calcium-channel blocker) may be important for optimal renoprotection, although further research is clearly needed in this area.

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Music in the HART Thursdays in August
KUMD is proud to sponsor Music in the HART at Lake Place Park in downtown Duluth.
Music in the HART (Historic Arts & Theatre District) concert series runs every Thursday of August, beginning August 2. This free, family-friendly event will feature music performed by new bands each week, accompanied by food and beverages along the shore of Lake Superior.
Thursday, August 2, 9, 16, 23, & 30.
Time: 4:30pm - 6:30pm
Location: Lake Place Park
N 2nd Ave E & East Michigan Street
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Rita Maxwell had no idea she was about to lose the job she’d had for nearly 20 years when her boss told her to meet him in the conference room at the end of the work day.
“I was completely taken aback when he called me into the meeting room,” said Maxwell, who was let go in early 2017. “There’s just not a lot of loyalty anymore.”
From $22 an hour to $11: GM job cuts in Ohio show a hot economy is still leaving parts of America behind
The United States has shed more than 2.1 million administrative and office support jobs since 2000, Labor Department data shows, eroding what for decades had been a reliable path to the middle class for women without college degrees.
The job losses affecting administrative assistants, bookkeepers, clerks, data entry specialists, executive assistants and secretaries have largely continued even as the economy recovered from the Great Recession, suggesting these jobs aren’t coming back.
Employment in administrative support positions has fallen to 1986 levels, and the Labor Department predicts that secretaries and administrative assistants will see the largest job losses of any occupation in the coming decade.
Since her layoff, Maxwell has only been able to land temporary jobs that pay $13 to $16 an hour — about a third of the roughly $80,000 annual salary she made in her final years at the search firm. Retraining did not seem like a realistic option in her mid-60s, she said.
A lot of companies simply “ghost” her, Maxwell said, not calling or emailing to let her know the outcome even after she came in for a final-round interview. She has run down her savings and dipped into her retirement fund to pay the mortgage on the bungalow house in Manassas that she purchased in 2011. If she can’t land a full-time job by the spring, she said, she’ll have to put her home up for sale.
“I was part of the women’s lib generation. I was proud I was able to support myself and not have to depend on somebody else to keep a roof over my head,” Maxwell said. “But what in the world am I going to do if I don’t land somewhere?”
The U.S. unemployment rate is 3.6 percent, a half-century low, and there are more job openings than unemployed Americans. Technology has created more positions than it has destroyed, economists say. But although the nation is likely to have many jobs for years to come, it’s less clear whether they will be well-paid jobs.
‘This doesn’t look like the best economy ever’: 40% of Americans say they still struggle to pay bills
On the presidential campaign trail, the conversation has focused mainly on the plight of workers losing manufacturing jobs (and potentially truck-driving jobs) to automation or trade. Most of those workers are male. Almost no attention has been paid to the upheaval that women in administrative positions are facing, said Martha Gimbel, a labor economist and former research director for the Hiring Lab, even though the scale of job losses is not far off from what occurred in blue-collar sectors.
“If you think about the amount of emotional energy we’ve devoted to what the future of truck drivers is as opposed to the future of administrative assistants, it’s mind-boggling,” Gimbel said. “We’re so focused on jobs that men do that we allow the suffering of women in this area to be silent.”
The nation has shed 2.9 million production jobs since 2000, according to Labor Department data. (Although manufacturing has lost even more than that, other jobs in welding and specialized computer operation have grown.)
Administrative positions have been lost to automation and outsourcing. Nearly 20 percent of administrative assistants have moved into something else entirely, such as sales or customer service roles, job site LinkedIn found.
“Up to about five years ago, the trend was to replace administrative work with cheaper labor in India or the Philippines,” said Phil Fersht, head of HFS Research, which works with clients on automation strategies.
“The new trend is to actually replace administrative work with robotic software,” he said. “I saw a bank in Brazil recently replace 600 staff with basically a chatbot.”
But a third threat is also at play: upskilling. Companies increasingly want a college degree for administrative positions, recruiters say, making it even harder for those who are laid off to land one of the roughly 18 million remaining administrative jobs.
“For non-college-educated workers, the landscape of opportunity is contracting and narrowing,” said David Autor, an MIT economist whose research found that workers without college degrees face about as tough of a time in cities as they do in rural areas. “We have tons of jobs for lesser-educated adults, but we have very few good careers.”
Among the 10 jobs expected to add the most employees in the next decade, six pay less than $27,000 a year. Jobs are growing at the high end and low end, a “barbell” economy.
The changes are falling especially hard on women over 50.
Elizabeth Espenshade, from Elizabethtown, Pa., walked right into an administrative assistant job at a steel company after graduating from high school in 1975, believing, like many factory workers, that it would last a lifetime.
When steel ran into trouble in the 1980s, she was laid off but transitioned to a job in state government. She worked for three decades as an executive assistant at the Pennsylvania auditor general’s office until she was let go in 2013 at age 57 because of budget cutbacks.
Since the layoff, she has found jobs, but none have paid even half of the $29 an hour she earned in her final years in state government.
“I think technology is taking over everything. It’s taken away a lot of our work,” Espenshade said. “I needed three more years to get full retirement, but I was pushed out the door.”
Espenshade initially fell back on a side job that she’d had for many years, doing data entry in a trucking company’s billing department. But that role was outsourced to India in 2016.
Today, Espenshade works part time at a nonprofit drug and alcohol counseling service. She said she enjoys the work, but it pays $13 an hour, complicating her hope of retiring soon. Staff at PA CareerLink, a government job center, urged her to retrain for a new career, but she didn’t think that was practical given her age.
“I went for job interviews, including at a hospital, and they all told me I was ‘overqualified,’ ” Espenshade said. “Realistically, I was 57, and they didn’t want to train me.”
Several recent studies have found substantial evidence that women over 50 get far fewer callbacks for job interviews and face a harder time than older men in job hunting.
“The finding of discrimination in hiring for older women is pretty clear,” said David Neumark, an economics professor at the University of California at Irvine who looked at results from 40,000 job applications, including in administrative fields.
More than half of workers 50 and over are let go involuntarily, and only 1 in 10 of those workers ever earn as much again, Urban Institute found. Recruiters for executive assistant positions say C-suite professionals now want their assistants to have college or even graduate degrees in business or law.
“Clients want a different person today, not the same type of person they had in the past. They see this more like a chief of staff role,” said Melba Duncan, a former assistant to private equity giant Peter G. Peterson and founder of the Duncan Group, which does human resources consulting. “There’s often a request for a four-year degree.”
As the requirements have gone up, pay is rising at the high end, and more men are entering the field. In the early 2000s, administrative jobs were nearly 80 percent female, but that has since dropped to about 70 percent.
Groups like the International Association of Administrative Professionals urge members to get more credentials. They offer a certificate program that covers technology, project management and business writing.
In a 2018 IAAP survey, more than half of the respondents said what they want most is leadership training. Duncan’s group hears that frequently, too, and offers a six-day course at Columbia University aimed at support staff.
Some executives say administrative cuts have gone too far. They say there’s a business case to having a human at the front desk and handling key client phone calls.
“The thing we found you can’t replace with technology is knowing the institutional memory of a place and the client relationships that matter the most,” said Kathy Tunheim, chief executive of Tunheim, a communications firm in the Minneapolis area.
Listen on Post Reports: Since 2000, the US has shed more than 2.1 million administrative and office support jobs. “The vast, vast majority of those jobs are held by women,” says reporter Heather Long.
Tunheim praised her assistant, Ginny Melvie, for her ability to befriend people over the phone, a skill that has helped win clients.
Melvie, 64, still enjoys the job but said her role has changed significantly since she started at the firm in 1999. Initially, she worked full time just for Tunheim. Today, she works part time (by choice) and supports up to six people.
“CEOs still need you. They need someone who is reliable and professional. Sometimes you have to make decisions for your boss because they are gone,” Melvie said. “In some respects, the pressure is a little bit more now.”

domain: news


By Avi Salzman
Fitch slashed Greece’s long-term debt rating to CCC from B+ on Wednesday as the European Union and the IMF still haven’t come up with a fully funded plan to bail the country out, and private creditors may be on the hook to help fund the bailout.
“Today’s rating downgrade reflects the absence of a new, fully-funded and credible EU-IMF programme for Greece, coupled with heightened uncertainty surrounding the role of private creditors in any future funding, as well as Greece’s weakening macroeconomic outlook,” the ratings agency said in a statement.
Fitch had placed Greece on a “ratings watch” in May as the IMF and EU starteed to discuss how to deal with the struggling country. Greece has since adopted an austerioty plan, but the EU and IMF haven’t finalized a deal to inject stimulus funds into the country.
“New money is required to address Greece’s fiscal funding shortfall that would otherwise emerge in 2012 – a key weakness of the current EU-IMF programme highlighted by Fitch at the turn of the year. Fitch had expected the uncertainty surrounding new money, along with the role of private creditors, to be resolved with the completion of the fourth review of the current EU-IMF programme earlier this month. The agency notes that while the main parameters of a new multi-annual adjustment programme were discussed at an Ecofin meeting on 11-12 July, no further clarity on the volume and the terms of new money or the nature of private sector participation was forthcoming.”


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Known as the “Brazilian Venice” for its many rivers and also as the land of Frevo, Recife is one of the main capitals of Northeast Brazil, with a rich history, vibrant culture and natural beauty.
If you want to know what to do in the city, see the main tourist attractions in Recife to add to your itinerary, as well as some tips on what to do at night in the city.
Where to visit in Recife? 13 tourist spots to visit
From Marco Zero in the city to the beach in the south zone, there are several options for tourist places in Recife. See below.
It is the zero point where the city of Recife was founded, in the 16th century and, without a doubt, the great postcard of the city.
In the center of the square, located in the Recife neighborhood — which is listed by Iphan —, the “Rose of the Winds” is painted, warning that this is where it all began.
The site also brings together several historical and cultural monuments, such as Caixa Cultural do Recife, the Pernambuco Handicraft Center, as well as a deck with several bars.
Marco Zero is one of the main tourist attractions in Recife: an ideal place to take pictures, enjoy the view of the Capibaribe River (and also see the Francisco Brennand Sculpture Park from afar) and feel the atmosphere of the city.
Francisco Brennand Sculpture Park
The Francisco Brennand Sculpture Park is one of the tourist sites in Recife that also draws attention: a set of works by the artist from Pernambuco, Francisco Brennand, installed on an artificial reef on the edge of Marco Zero.
The park’s highlight is the Column of Crystal, a 32-meter-high sculpture that symbolizes the milestone of the 500th anniversary of the discovery of Brazil.
The park can be accessed through a catamaran ride on the Capibaribe River or by car through the neighborhood of Brasília Teimosa.
Paço do Frevo
Paço do Frevo is a museum dedicated to the musical rhythm and dance that emerged in Pernambuco over 100 years ago.
The construction is more recent and is located in the Recife neighborhood, also known as Old Recife.
The museum occupies a historic building in the Recife Antigo neighborhood and features interactive exhibitions, workshops, concerts and a collection of over 12,000 items related to frevo.
It is an option of where to visit Recife and an opportunity to learn more about this cultural expression from Pernambuco, which is an Intangible Heritage of Humanity.
Rua do Bom Jesus
Rua do Bom Jesus is one of the oldest and most charming streets in Recife, in the Recife neighborhood as well, with colorful mansions dating from the 17th century. It was considered the 3rd most beautiful street in the world by Architectural Digest.
But in addition to beauty, it holds a part of the city’s history: the Kahal Zur Israel Synagogue, the first in the Americas, which today functions as a museum about the Jewish presence in the region. The previous name of the street was Rua dos Judeus.
Still in it, it is possible to take the opportunity to visit the Embaixada dos Bonecos Gigantes, a space that houses more than 100 dolls that parade in the carnival of Olinda, a neighboring city. The street also has bars and a seasonal feirinha.
Boa Vista Market
Mercado da Boa Vista, located in the neighborhood of the same name, is one of the places to visit in Recife that holds one of the most traditional public markets in the city, opened in 1875.
The site used to be the stable and Cemetery of the Chapel, which today is the Church of Santa Cruz, and functioned as a slave market.
In it, you can find a variety of regional products, such as handicrafts, clothing, food and spices.
It is also an option to discover some of the delicacies of Recife’s local cuisine, such as bolo de rolo and tapioca.
The Malakoff Tower is a historic monument that was built in 1855 to serve as an astronomical observatory and gateway to the Navy Yard.
The military character of the work appears both in the façade and in its plan, also making reference to the mosques of the East.
It is opposite Praça do Arsenal, close to Paço do Frevo and Rua do Bom Jesus. Currently, it is a cultural center that hosts art exhibitions, events and a digital planetarium. From the top of the tower, you can have a beautiful panoramic view of the city.
The Capela Dourada, formally named Capela dos Novices da Ordem Terceira de São Francisco de Assis, is one of the main tourist attractions in Recife and one of the most impressive churches, located in the Convent of Santo Antônio.
The chapel was built in the 18th century and has an exuberant Baroque decoration, with lots of gold, carvings and Portuguese tiles. The artistic and historical wealth draws attention.
It is part of the Recife Sagrado project, along with other temples: Madre de Deus, Our Lady of the Rosary of the Black Men of Recife, Basilica of Our Lady of Penha, Santa Tereza D’Ávila of the Third Order of Carmo and the Kahal-Zur Israel Synagogue .
Cais do Sertão Museum
The Cais do Sertão Museum is one of the places to visit in Recife. A modern and interactive structure, its purpose is to pay homage to the culture and history of the northeastern hinterland. It was opened in 2014.
It is located in the former Armazém 10 in Porto do Recife and is inspired by the life and work of singer Luiz Gonzaga, who was born in Pernambuco.
There are thematic rooms, objects, videos, music and recreational activities that portray the diversity and beauty of the hinterland. The museum offers visitors both temporary exhibitions and a permanent collection,
Patio de San Pedro
Pátio de São Pedro is a historic square located in the São José neighborhood, surrounded by colorful houses and the Basilica Cathedral of São Pedro dos Clérigos.
The courtyard is a cultural space that hosts events such as handicraft fairs, nightly music shows and popular festivals.
It is also home to the Chico Science Memorial, the singer from Recife who was an exponent of manguebeat. It is possible to appreciate the colonial architecture and the typical gastronomy, through the restaurants in the region.
Five Points Fort
Forte das Cinco Pontas, in the neighborhood of São José, is the only remaining fort from the time of the Dutch occupation in Recife, built in 1630. It has this name because it originally had five bulwarks, but today only four remain.
Historically, the fortress had the function of defending Recife and also functioning as a prison.
Today, the Museum of the City of Recife operates inside the fort, which has exhibitions on the history and heritage of the capital of Pernambuco. It’s more of a tour to learn more about the history of the city’s population.
Jardim do Baobá is one of the places to visit in Recife, being a space for contemplating the Capibaribe River, in the neighborhood of Graças, in the North Zone of the city.
Its icon is the centenary tree, sacred to indigenous, African and Brazilian cultures.
The 15-meter tree has been listed as a Recife heritage site since 1988.
The natural space also has special lighting, spaces for picnics and a floating pier to enjoy the river landscape. It is an ideal place to relax and get in touch with nature.
Parque da Jaqueira is one of the largest urban parks in Recife, also located in the neighborhood of Graças, it is another option of where to walk in Recife.
The park has a green area of more than 70,000 square meters, where jackfruit trees stand out, fruit trees typical of the region.
The site also offers leisure options for all ages, such as walking and cycling tracks, sports courts, playgrounds and gym equipment.
Boa Viagem beach
In the South Zone of Recife, there is the only beach in the city — along with Pina —, with about 7 kilometers. The beach has a well-structured edge, with a boardwalk, bike path, kiosks and coconut trees.
The water is clean and very warm, but you have to be careful with sharks that can appear in the deeper area.
With cases of attacks in Pernambuco, some parts contain warnings for bathers not to enter. However, it is still one of the places to visit in Recife, where it is possible to enjoy the sun, the sand and the view to the full extent — and the water, with due care.
What to do in Recife at night?
If you want to enjoy Recife’s nightlife after seeing the sights during the day, there are some suggestions for what to do in the city at night.
- Currency Street : It is a historic street that turns into a bohemian point at night and is located in the Recife Antigo region. There you can find several bars and restaurants with live music. It’s a place in Recife to have fun, dance and meet new people;
- Catamaran Tour : as Recife is a city crossed by several rivers. A different and romantic way to see the city at night is to take a catamaran ride along the Capibaribe River. The tour lasts about an hour and a half and passes through several illuminated points of the city, such as the historic bridges;
- Boa Viagem Fair : if you like shopping or just strolling along the beachfront at night, you can visit the Feirinha de Boa Viagem. There you can find various handicraft products, such as clothes, bags, jewelry and souvenirs.
(Posted by João Guimarães)
Source: CNN Brasil
I’m James Harper, a highly experienced and accomplished news writer for World Stock Market. I have been writing in the Politics section of the website for over five years, providing readers with up-to-date and insightful information about current events in politics. My work is widely read and respected by many industry professionals as well as laymen.

domain: geography


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It’s that time of year again, when the most dapper of men convene in Florence, Italy for Pitti Uomo to peacock their best dressed threads. And we simply can’t get enough . . .
The next stop after Cambodia: Northern Vietnam. We spent the first couple of nights on a privately chartered boat, traversing through multiple clusters of limestone islets that make up mystical Ha Long Bay and occasionally taking a break from the stunning scenery to explore cavernous caves, visit floating fishing villages, and kayak to hidden lagoons. Bustling Hanoi, a stark contrast to serene Ha Long Bay, was next on the itinerary. I took great pleasure in walking through the streets of The Old Quarter amidst the abundance of scooters, plethora of street food vendors, and boundless shops selling textiles and handicrafts. And the only way to keep up was to sustain oneself on deliciously sweet and fragrant Vietnamese coffee . . . lots of it.
The scene was set for Stella McCartney‘s pre-fall presentation at Americas Society Art Gallery on Park Avenue. While drinking champagne and playing games of Scrabble, models were sketched by artists at easels donning outerwear of exaggerated proportions, patterns of strips and jacquards, well-tailored separates in brilliant color combinations, and colorblocked eveningwear. Effortlessly playful and oh-so minimally chic, the collection indeed addresses the need of every modern woman’s wardrobe. Honestly, so good!
Sharon Montrose has combined her passion for photography with her love of animals to create the most amazing collection of animal portraits. From adorable photographs of baby critters to hilarious snapshots of tails to stunning images of wildlife, there is something for everyone in her Animal Print Shop. I personally need a pair of those donkey ears!


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Train crash in Iberville Parish kills man from North LA
IBERVILLE PARISH- A 61-year old man was killed this evening, after a train smashed into his car.
It happened on LA 1, near the Rocky Canal. Iberville Parish Sheriff Brett Stassi told WBRZ, that's between White Castle and Donaldsonville and is on the Iberville and Ascension Parish Lines.
Stassi said the man crossed the tracks when a train approached at a high rate of speed. The man died at the scene.
His name has not been released.
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Lee High School will get football program next year
Locals pack the streets for White Light Night
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'You have our attention': Police hold press conference amid crime wave in...
Mayor pushing new tax proposal for traffic improvement


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Do you want a say in where your student fees go? Do you want a voice when the Board of Regents talks to student representatives? You need to #VoteforASUNM! The Associated Students of UNM is THE voice for undergraduate UNM students; it's where UNM policy makers go to get input from students, and it determines where your student fees end up. The only way for YOU to have a voice is to VOTE!
The ASUNM Elections Commission's purpose is to ensure that the ASUNM undergraduate student government elections are run in a fair and consistent manner. The Elections Commission is responsible for the Homecoming Election, the Fall Senatorial Election and the Spring Presidential, Vice Presidential, and Senatorial Elections. Click the links above for election results, how to run, and other important information.
Why should you #VoteforASUNM?
Fall 2018 Senate election packets will be available in October. Stay Tuned!
The Elections Commission is accepting applications to serve as an Elections Commissioner. Please complete an ASUNM Application to apply.

domain: politics


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I'm an expert in communications, professionally and personally, and I love to discuss the art of communication itself! So whether it's communication relative to work, texting, intimacy, awkward conversations, email, or even encounters with strangers I'm interested in reflecting on the value, or lack thereof, that these exchanges bring to our lives.
Listen and subscribe to I'm Speaking Now wherever you get your podcasts and follow me on @iamspeaking now on Instagram!

domain: hobby


text:
By incorporating smallholders into their supply chain, firms in Sierra Leone have identified a competitive opportunity to support local agriculture and contribute to rural livelihoods. Find out how Jolaks, a palm oil refinery and processing plant in Wellington, Sierra Leone, is transforming oil palm production.
Made in Salone: Transforming oil palm production in Sierra Leone
Topic: Made in Salone
Sector: Agriculture, Manufacturing, Oil palm
Geographic Focus: Sierra Leone
Published by: Invest Salone

domain: agronomy


A DIN rail power meter is an electrical metering device used to measure and monitor the electrical parameters of a power distribution system. Here are some of the components that make up a typical DIN rail power meter:
Input circuit: This circuit is responsible for measuring the incoming electrical signals, such as voltage and current, and converting them into a form that can be processed by the meter.
Processor and memory: This component processes the incoming electrical signals, calculates the power and energy consumption, and stores the data in memory for later analysis.
Display: This component provides a visual display of the measured data, including voltage, current, power, energy, and other parameters.
Communication interface: This component allows the power meter to communicate with other devices and systems, such as building management systems, energy management systems, or other monitoring and control systems.
Power supply: This component provides power to the meter itself, typically through an external AC or DC power source.
Housing and mounting: The meter is typically housed in a compact, DIN-rail-mounted enclosure that can be easily installed in a control panel or distribution box.
Sensors and transformers: Depending on the specific application, the power meter may include additional sensors or transformers to measure other parameters, such as temperature, humidity, or power quality.
Overall, a DIN rail power meter is a complex device that includes a range of components and subsystems designed to accurately measure and monitor the electrical parameters of a power distribution system.


text: Sometimes we go on holiday. And sometimes we take a trip that changes our life forever. We aspire to finding stories that might flip things for you, challenging die-hard travel habits, uncovering new ways of seeing the world. But we’re just reporting what’s out there. These awards salute brave, brilliant individuals who are the ones literally changing our minds when we think about travel. Come meet them.

domain: travel


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- Table View
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Fundraising wunderkind Bilaal Rajan shares his tips for effective fundraising, using examples from his own amazing life to show how it can be done -- and how you can have fun doing it. The second part of the book is a section entitled Eight Principles to Maximize Your Full Potential, which includes exercises to help you identify and attain your dreams.
The year is 1935 and Maggie Sullivan's world has fallen apart. Maggie has grown up in a close-knit mining community perched atop a mountain in British Columbia. But now her father has been killed in a mine explosion and she is being forced to leave the only home she has ever known. To make matters worse, she must also leave behind her best friend Lucky, the three-legged dog that was a special gift from Pa.
It's Christmastime! And irrepressible, excitable Curious George has just the spirit for it. He can't wait to help his best friend, The Man with the Yellow Hat, pick out their holiday tree. At the tree farm, however, amid all the excitement of finding the perfect specimen, George gets carried away, as usual--atop his favorite tree! Hiding in the tree's branches, George finds himself delivered to the local children's hospital, where his tree trimming antics cheer the children and he gets to meet a jolly man in a bright red suit. For more monkey fun, investigate www. curiousgeorge. com and discover all the latest on Curious George, books, promotions, games, activities, and more!
Being first isn't always best, as Pinkerton Pig finds out after an encounter with a mean Sand Witch. As always, Helen Lester's wonderfully offbeat humor and Lynn Munsinger's whimsical illustrations result in a hilarious lesson about piggishness. The picture book duo of Lester and Munsinger has created six previous books, including the award-winning TACKY THE PENGUIN.
Curious You: On Your Way! is a perfect sendoff for children of all ages entering a new phase of their lives. Follow along with George in classic scenes from many of his original books as he provides words of congratulations and encouragement to anyone who has accomplished much but still has many things to see, to do, and to dream! The ideal gift book for a graduation, a promotion, or any occasion, Curious You: On Your Way! helps to celebrate all of the milestones of our lives. This inspirational story reminds readers young and old who are moving up or moving on that they have a special someone cheering for them as far as their curiosity can take them!
Tacky the Penguin is back, this time trying to compete with Goodly, Lovely, Angel, Neatly, and Perfect in the iceberg-wide Penguin Cheering Contest. But will Tacky ever be able to learn the synchronized moves and win the contest?
Psychologically astute and passionately written, Molly Worthen's remarkable debut charts the intricate relationship between student and teacher, biographer and subject. As a Yale freshman, Worthen found herself deeply fascinated by worldly-wise professor Charles Hill, a former diplomat who had shaped American foreign policy in his forty-year career as an adviser to Henry Kissinger, George Shultz, and Boutros Boutros-Ghali, among others. Hill was never afraid to tell students how to think or what to do, and the Grand Strategy seminar he co-taught had developed a cult following. The Man on Whom Nothing Was Lost is at once the biography of a political insider and the story of how its author evolved as she wrote it. In a moving, highly original work, Worthen conveys the joy and the heartache of uncovering the human being behind one's idol.
When Guerrilla Marketing was first published in 1983, Jay Levinson revolutionized marketing strategies for the small-business owner with his take-no-prisoners approach to finding clients. Based on hundreds of solid ideas that really work, Levinson's philosophy has given birth to a new way of learning about market share and how to gain it. In this completely updated and expanded fourth edition, Levinson offers a new arsenal of weaponry for small-business success including * strategies for marketing on the Internet (explaining when and precisely how to use it) * tips for using new technology, such as podcasting and automated marketing * programs for targeting prospects and cultivating repeat and referral business * management lessons in the age of telecommuting and freelance employees Guerrilla Marketing is the entrepreneur's marketing bible -- and the book every small-business owner should have on his or her shelf.
Fragility was a solid piece of work. But despite her sturdy exterior, Fragility was fragile. Anything and everything hurt her feelings. In the most benign compliment, Fragility heard an insult. No one could even say she looked nice without evoking images of big, squishy cupcakes-since they are also nice-and causing Fragility to flop on the ground and weep. Fragility's friends stop speaking to her for fear of another fit, but Rudy, a very rude bully, has other ideas. In the face of real insults, will Fragility finally learn to take a compliment?
Many Americans will never experience the gut-wrenching act of sending a loved one off to war, or the joy and stress of welcoming him or her home. Still less known to most of us are the anxiety-ridden moments between these two scenes, the day-to-day reality of life in a military family when a loved one is deployed in a combat zone. While They're at War takes us inside hearts and homes to illuminate the unseen aspects of this critical American story. We meet two very different women, Marissa Bootes and Beth Pratt, both newlyweds experiencing life alone at Fort Bragg, North Carolina, while their husbands are fighting in Iraq. Through the extraordinary stories of these and other military spouses, Kristin Henderson reveals the overwhelming effects of separation -- from fears of death to worries about financial stability and marital fidelity. She also explores the official and unofficial support systems that strain to help homefront families endure some of their greatest challenges.
High above the rooftops of Rome, Angelo begins his work restoring the façade of a once glorious church. As with every project, he starts his final masterpiece by clearing away the years of debris left behind by the many pigeons who nest in the nooks and crannies of Rome's great architecture. There, among the sticks and feathers, he discovers a wounded bird. Finding no safe place to leave her, Angelo becomes the bird's reluctant savior. As the church nears completion, Angelo begins to worry about the future of his aviary friend. "What will become of you? Where will you go . . . where will you . . . live?" he asks her. Realizing what he must do, Angelo returns to the church to add one final finishing touch. Through his artistry as a master craftsman he answers the questions about his humble friend and assures that he will not be forgotten. With his expressive illustrations, filled with detail and humor and infused with the warm, terra-cotta glow of the Mediterranean, David Macaulay will once again capture his readers' hearts and imaginations with this poignant story of enduring friendship.
When Nick and Kia arrive for try-outs for the basketball team they played on the previous year, they are surprised to learn that their coach is retiring. The surprises continue when the new coach is introduced. Coach Barkley, a former college star known for his fierce desire to win, missed out on a pro career due to a serious injury. Though the coach has been away from the game for many years, his competitive instincts are as strong as ever and his aggressive coaching techniques are a new experience for these kids. Practices are long and hard and not nearly as much fun as they used to be. Suddenly making the rep team no longer seems the sure thing that Nick and Kia expected when they came to try-outs. The new coach expects near perfection from the youngsters and does not deal well with anything less. This is hard on Nick and Kia, but especially difficult for the coach's son, L.B., who is also trying out for the team. When the coach matches them up against a team of older players and then refuses to accept their loss, the kids begin to wonder if they even want to make this team. Nick, Kia and L.B. finally have to decide whether to play for a tyrant or to take a stand on principle and face the consequences.
Some days it's just easier not to go to school at all. Adam has been slacking off lately, but today he stuck around to see his girlfriend. When Josh, who has been bullied mercilessly, brings a gun to school, the building is locked down and Adam is forced to risk everything to save himself and to find Zoe before Josh does. Calling on reserves he didn't know he had, Adam could end up a hero -- or a victim.
Fifteen-year-old Sarah Greene's father -- chef by day, camera buff by night -- choked to death on a piece of steak. It was the best day of Sarah's life. But a year later, Sarah still struggles with the legacy of her father's abuse. While other girls her age are determined to find boyfriends and part-time jobs and dresses for the prom, Sarah is on a search-and-destroy mission: to find the shoe box containing her father's collection of kiddy porn. After a brief skirmish with the law, Sarah is sentenced to do community service hours at Camp Dog Gone Fun, a summer program for shelter dogs. With the love of a big goofy dog named Judy, the friendship of Sullivan, a guy with problems of his own, and the support of a few good adults, Sarah begins to understand her past and believe in a brighter future.
Jason is an outsider. A recent immigrant from China, he lives in a close-minded town with his mother and younger brother. Falling in with the wrong crowd, trying to fit in, Jason takes chances and ends up in trouble with the police. Holding on to his friendship with a Native boy, also an outsider, Jason finds he needs to fight to belong and to find a new home.
Sam Campbell's school team, the Laggan Lairds, always loses. When someone suggests that their name be the Laggan Lard Butts, Sam thinks the team should change its name. What is a Laird anyway? The basketball coach agrees, and soon the whole school is involved in an election for a new team name. Sam and his friends nominate the name Lard Butts. When the basketball team starts winning games after a warm-up cheer of "Go Lard Butts!" it seems the Lard Butt campaign might actually win the election.
Izzy and Julia have been on the same team for years. Izzy is frustrated that Julia spends too much time cherry-picking and getting all the credit when they score. But when someone starts threatening the team and their home field is sabotaged, the friends must work together to find the answers. Why would someone threaten their star player? And what is the connection to a century-old train robbery and the rumor of buried treasure? Trying to solve the mystery and keep the team in the playoff race, Izzy and Julia find themselves in deeper than they thought, and in more danger than they imagined.
Dime is fifteen and always angry. Her parents don't understand her, and her brother was paralyzed in an accident. When the fights and accusations become too much, Dime moves in with her brother. But her troubles follow her. Until she realizes that she has to start taking some responsibility, nothing will change.
Kelly loves the cabin she has made from a refrigerator box. It has a window with curtains, pictures on the walls, a cabin-sized table and a wonderful view. It sits in the vacant lot next door, transformed into the rugged farm of a pioneer family. Now if only Kelly can find the right person to share it with.
The year is 1909 and Joseph has just immigrated to the United States from Russia. He thinks that life in New York City will be wonderful, but he has not bargained for the challenges of learning English and of resisting the pressures to skip school, steal and fight to earn a place among the boys in his neighbourhood. Just Call Me Joe presents a full picture of life in New York City for the working poor. Anna, Joe's older sister, struggles to cope with the terrible factory conditions of the time. Aunt Sophie must take in boarders to make ends meet. And Joseph must both accept change and remain true to himself in a new city with new challenges.
Reese loves horses and longs to be a competitive show-jumper. When the leased horse she rides is sold she is left riding the orneriest horse in the stable. She decides she must find a horse of her own. Her parents can't afford a trained horse so she decides to buy a wild horse at auction. Outbid, she discovers that many of the wild horses are will be sold for slaughter. Determined to save the horses from a terrible fate she finds herself in deeper than she expected and fighting for her life.
The Great Match Race is a captivating account of America's first sports spectacle, a horse race that pitted North against South in three grueling heats. On a bright afternoon in May 1823, an unprecedented sixty thousand people showed up to watch two horses run the equivalent of nine Kentucky Derbys in a few hours' time. Eclipse was the majestic champion representing the North, and Henry, an equine arriviste, was the pride of the South. Their match race would come to represent a watershed moment in American history, crystallizing the differences that so fundamentally divided the country. The renowned sportswriter John Eisenberg captures all the pulse-pounding drama and behind-the-scenes tensions in a page-turning mix of history, horse racing, and pure entertainment.
Hunting Eichmannis the first complete narrative of a relentless and harrowing international manhunt. When the Allies stormed Berlin in the last days of the Third Reich, Adolf Eichmann shed his SS uniform and vanished. Following his escape from two American POW camps, his retreat into the mountains and out of Europe, and his path to an anonymous life in Buenos Aires, his pursuers are a bulldog West German prosecutor, a blind Argentinean Jew and his beautiful daughter, and a budding, ragtag spy agency called the Mossad, whose operatives have their own scores to settle (and whose rare surveillance photographs are published here for the first time). The capture of Eichmann and the efforts by Israeli agents to secret him out of Argentina to stand trial is the stunning conclusion to this thrilling historical account, told with the kind of pulse-pounding detail that rivals anything you'd find in great spy fiction.
"The zany illustrations suit the amusingly outraged tone of the text. Funny and original. " -Kirkus Reviews Bad days-we all have them. But what do we do about them? Meet Alicia and her trusty friend, Neptune. Alicia is usually a cheerful child who likes to dance very fast and stand on her head. What will she do when she wakes one morning feeling miserable? At first, none of Alicia's clever and quirky remedies, such as moping in her favorite chair and writing in her notebook, seems to cure her gloom. Then in a place least expected, a delightful surprise awaits, and Alicia makes a joyous discovery. Lisa Jahn-Clough has created a unique character with a spunky spirit all her own. Alicia will charm her way into the hearts of readers young and old on any day.
It's common knowledge that Tacky was never the best- dressed penguin, but when he and his friends prepare for the arrival of the emperor, Tacky gets carried away and ends up in more than just elegant attire! Tacky brings his own unique brand of humor and entertainment to the emperor's visit. Here is another wacky addition to Tacky's myriad adventures in which friendship, kindness, and laughter always win out! Tacky fans will be carried to new heights of hilarity by this latest Tacky tale.
Select your download format based upon: 1) how you want to read your book, and 2) compatibility with your reading tool. For more details, visit the Formats page under the Getting Started tab.See and hear words read aloud
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domain: literature


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On the Occasion of World Cancer Day, Vikasatarangini Srikakulam conducted two mega medical camps at Lakshmudupeta village, Etcherla mandal and Dr. Ambedkar University, Srikakulam on 3rd February 2019 respectively.
Medical Camp at Lakshmudupeta village, Etcherla mandal (03rd Feb 19) :
The camp was conducted in collaboration with team of doctors from GEMS srikakulam (Smt. Lakshmi Vasavi, Pathologist, Asst. Professor, RIMS Srikakulam, Sri M.Uday Kiran, MD General Medicine, Smt K.Ramya, Anaesthetist, Asst Professor) and Technicians from Zenith Diagnostics Lab for blood and urine tests.
Around 120 people in this village for the benefited by this Medical Camp. 31 Blood Tests for Hb, Blood Glucose and 07 Thyroid Tests were conducted.
- Blood Tests -31
- Thyroid Tests -7
- Hb Tests
- Blood Glucose
Antibiotics and Free Medicine distributed for the needy. Among these, the following cases are treated.
- Lung Infection – 2
- BP around 20
- Wounds – 3
- Low Back Pain and Joint Pains – 25
- Low Back Pain
- Joint Pains
- Tumours – 2 (benign 1, malignant suspect 01 referred to Higher Centres), Stroke 1 (follow up), Severe Anaemia – 5, Thyroid – 1, Diarrhoea – 2)
Dearth of Basic medical amenities, absence of 104 Vehicle visit in the village as shook Sri M Bhupala Rao, and worked with Vikasa Tarangini for conducting medical camp. Our team of Doctors mentioned thet people are being misdiagnosed and wrongly treated by RMPs resulting grave side effects. RMPs are unable to treat common diseases like hypertension and diabetes.
Most of the people with joint pains are being treated with painkillers years together leading to kidney problems, women are anaemic and children are undernourished.
We thanked Smt Dr. Vasavi from Zenith Diagnostics who sponsored Free Kits for Diagnoses.
Medical Camp at Dr. Ambedkar University, Srikakulam(4th Feb 2019):
Vikasa Tarangini Srikakulam in collaboration with GEMS Hospital, Lions Club, Indian Dental Association conducted mega medical awareness programme and mega medical camp on the occasion of World Cancer Day 4th Feb,2019 at Dr. Ambedkar University, Srikakulam
The following have attended programme
- Dr.K. Ramjee, Vice Chancellor,Ambedkar University,
- Dr.G.Tulasi Rao, Principal Ambedkar University
- Dr. M. Venkataramana, Oncologist, GEMS,Srikakulam
- Dr. Rama Chandra Raju ,Vice Chancellor, Krishna University, Guntur
- Dr. K. Sreeramulu, Indian Institute of Information Technology, Director, Etcherla,
- S. Mohanrao, Lions Club President(Rtd CEO SETSRI)
- B. Lakshmanarao, Academic Director,Vaishnavi Engg college.
- Dr P. Satheesh, Indian Dental Association Secretary,Srikakulam.
- Dr. P.Prakash, NTR Vaidya Seva Dist. Coordinator
- Dr. D.Praveen GEMS coordinator.
- Smt. M. Usha Sree, Vikasatarangini Dist. Coordinator Attended the programme.
By this programme around 500 students for made aware of the cancer causes and treatment. medical camp have conducted blood test group, hb, eye and tests.
Oncologist Dr Venkata Ramana spoke about various risk factors causing cancer, preventive measures, and about cervical cancer vaccine.
Smt. Usha Sree, VT Dist coordinator raised the awareness on cancer and also addressed the gathering with the key points regarding Mahila Arogya Vikas and it’s detailed report . Both Medical Camps became very useful to all sections of the people.


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When it comes to attracting pollinators, Saururus chinensis is a bit of a chameleon. By turning some of its leaves white, it can attract more visitors. But why don’t the leaves stay white?
The overall results suggest that near-complete hybrid seed failure can evolve fairly rapidly and without apparent divergence in reproductive phenology/biology.
This study investigates the conditions routinely used by genebanks and finds that standard practice may not be optimal for subsequent seed longevity.
Under self-pollination induction three genotypes of P. rufum develop seeds from both meiotic and aposporous embryo sacs.
A comparison of wild-type Arabidopsis thaliana and PA-deficient mutants finds that peroxidase activity is significantly over-activated in mutant seeds.


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CIA chief Petraeus meets Fidan
ISTANBUL - Hürriyet Daily News
AFP photoDavid Petraeus, the director of the Central Intelligence Agency, staged an unscheduled tête-à-tête with his Turkish counterpart on Sept. 2 in Istanbul during which the spy chiefs discussed the Syrian crisis and the Arab republic’s possible transition process.
Petraeus was expected to leave Turkey yesterday, one day after arriving. Ankara was tight-lipped concerning Petraeus’ visit to Istanbul, with both Foreign Ministry officials and Prime Ministry officials giving identical answers: “We do not have such information [about the trip].”
The visit to National Intelligence Organization (MİT) head Hakan Fidan was the second unannounced visit by the CIA chief to Turkey in the last six months. In March, the United States’ top spy paid an unannounced two-day visit to Ankara to discuss the deepening instability in Syria, the joint fight against terrorism and closer cooperation on pressing regional issues “in the coming months.”
The issue of a transitional process in Syria was raised in the “operational planning” meeting between Turkish and U.S. delegations late last month in Istanbul. The aim of the meeting was to coordinate ongoing efforts to extend humanitarian aid to Syrians and to produce a common road map to shape a possible post-Baathist era. The meetings also raised the issue of the need for a smooth transition in Syria to avoid chaos in the country in the event that President Bashar al-Assad’s government collapses.


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Teabag folding is a kind of origami that was developed late in the 20th Century in Holland. Origami itself is a Japanese art of paper folding that dates back to antiquity. However, it has become a popular craft in many places around the world and has given rise to new designs and trends such as teabag folding.
Teabag folding was developed by a Dutch woman named Tiny van der Plas. She had been practicing origami for quite some time before she came up with this technique. The story goes that she was sitting at home one day having a cup of tea when she realized that she'd forgotten to get a birthday card for her sister. As she sat there, she began fiddling with the small paper envelope that her tea bag had come in. This gave her an idea for a new kind of origami.
This new kind of origami that Ms. van der Plas developed is made by using small square pieces of paper, like the packets that tea bags come in, and folding them in such a way as to create a three-dimensional interlocking design. Following the history of how this kind of origami was invented, teabag folding is often used to create embellishments for greeting cards. They are also sometimes used to affix to gifts and certificates of achievement. They can also be used to embellish pages of scrapbooks and photo albums.
The most common kind of teabag folding begins with a basic kite fold which is used to make three-dimensional rosettes. Because of this rosette shape, this common kind of teabag folding is also sometimes called "miniature kaleidoscope origami" or "kaleidoscope folding."
Since origami is a craft that lends itself to invention and personal expression, many paper folding artists have found ways to create other shapes using similar techniques to the one that Tiny developed in Holland. Some teabag folding designs yield flowers, birds, butterflies, snowflakes, or even religious symbols such as crosses or the Star of David.
If you are interested in learning how to do origami, you might want to begin with a slightly simpler pattern than teabag folding. Because the folds rely on precise symmetry and intricate work, this might be a difficult project for a beginner. To get started, go to your local craft store and look for a book on origami for beginners. You should also be able to pick up paper that is the perfect size and quality for your first projects.

domain: design


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Journal: Scientific Reports
Article Title: Modulation properties of factors released by bone marrow stromal cells on activated microglia: an in vitro study
Figure Lengend Snippet: (A) Scheme of the methods used to analyze BMSCs Proteins identification was done on an orbitrap LTQ XL with a protein threshold of 99% (FDR 0.1%) and peptide threshold of 97% (FDR 0.1%) and contained at least 2 identified peptides as parameters ( Supplementary data 1 2 ). (B) Label free quantification of immune modulators, neurotrophic and growth factors and apoptotic molecules identified in conditioned media obtained from BMSCs, spinal cord lesion (SCI) or control (non injured) using Scaffold_22.214.171.124. Label-free quantification was done on top3 of the total ion current (TIC). (BMP 1: Bone morphogenic protein 1, Cdh13: T-Cadherin, CLEC11a: C-type lectin domain family 11 member A CTGF: connective tissue growth factor, Epha 3: Ephrin A isoform 3, Epdr1: Ependymin related protein 1, FAM3C: family with sequence similarity 3, member C Gal 1: galectin 1; GAP-43: Growth associated protein 43, Ltbp: Latent TGF-beta binding protein, IgFbp 7: Insulin growth factor binding protein 7, MIF: macrophage inhibiting factor, PDGF: Platelet derived growth factor, PGF: placenta growth factor, spondin 2, SPARC, TIMP-1: Tissue inhibitor metalloproteinase 1 2).
Article Snippet: The chromatography system was coupled to a Thermo Scientific LTQ-Orbitrap XL mass spectrometer programmed to acquire in data-dependent mode.
Techniques: Sequencing, Binding Assay, Derivative Assay

domain: chemistry


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Synopses & Reviews
Famed raw foods chef Renée Loux celebrates the growing whole foods movement with The Balanced Plateover, containing 150 delicious, creative recipes and practical advice for leading a healthy, whole life
In her first book, Living Cuisine, Renée Loux showed how nutritious and satisfying raw foods cuisine can be. Now she takes a broader look at the benefits of a diet rich in natural, whole foods. Under the banner of "nutritional cross-training," Renée outlines the basic principles of such dietary plans as macrobiotics and Ayurveda, and dishes up flavorful whole foods recipes for optimal health--including Ratatouille Thin Crust Pizza, Roasted Spring Vegetable Salad, and Lemon Vanilla Ginger Snaps--with a nod to gluten-free living, blood sugar balance, and boosted immunity.
You are what you eat, Renée explains, but you are also what you use to clean your house and your skin, and so sprinkled throughout the book readers will find ideas for introducing the whole-foods philosophy to their home and beauty routines, including tips for composting and choosing a healthy water filter.
When Living Cuisine appeared, Alicia Silverstone applauded Renées recipes, saying: "Incredibly rich and delicious and full of health and restorative energy, her food is medicine." Part eco-friendly cookbook and part organic lifestyle guide, this new book reflects that same spirit, while presenting the essential elements of living well through whole foods, and living responsibly for a sustainable future.
"Loux's debut, Living Cuisine, was a raw foods (food perparation with low or no heat) primer. This follow-up has plenty of recipes that involve cooking, but retains the focus on 'choosing balanced whole foods over processed, denatured foods' for wellness and for pleasure. To that end, Loux introduces the Ayurvedic system of classifying food, and gives advice on 'finding out where it really comes from, and choosing the safest, most nutritious options.' She begins with 'The True Cost of Food,' laying out the number of pounds-per-acre of pesticides used in growing everything from potatoes to strawberries-and cows-as well as the large amounts of fuel used in shipping imported goods and the potential dangers of genetically modified foods. From there, she covers seasonality, macrobiotics, the basics of a whole foods pantry (including safer cleaning products), and clean water issues. The last two thirds of the book is comprised of Loux's recipes for everything from Velvet Nutmeg Nog to Lotus Manitok Wild Rice with Mâche; also included are takes on Sheherd's Pie, Salad Niçoise and Black-Eyed Peas and Collard Greens. The whole is produced with passion and expertise." Publishers Weekly (Copyright Reed Business Information, Inc.)
Famed raw foods chef Rene Loux celebrates the growing whole foods movement with over 150 delicious, creative recipes and practical advice for leading a healthy, whole life as she dishes up flavorful whole foods recipes for optimal health.
About the Author
RENÉE LOUX is a celebrated raw foods chef and former co-owner of the Raw Experience restaurant in Maui. She facilitates health retreats and workshops worldwide which incorporate whole living foods into a balanced lifestyle. She lives in Maui.


text: One of my favorite books about someone in the autumn of their life is EMILY, ALONE, by Stewart O’Nan. Emily Maxwell is an 80-year-old widow striving to navigate her senior years. Beginning just prior to Thanksgiving 2009, the story takes us through the next nine months of Emily’s life, trudging through the bleakness of a typical Pittsburgh winter, into the thrill of spring, and the hope of summer. She has lost her husband Henry and more recently her best friend, Louise. Attending funerals has become a common social event for Emily. Her two adult children and four grandchildren live in distant states. Emily only sees them on occasional holidays and an annual summer vacation to Chautauqua. Like so many older folks, Emily is lonely, only her aged spaniel Rufus a constant companion. Her day-to-day existence consists of predictable routine. Tuesdays, Emily and Arlene, her sister-in-law, go to Eat’n Park for the breakfast buffet. Wednesdays, her housekeeper comes to clean. On Sundays, Emily goes to church. She listens to classical music, does the daily crossword, eats, cares for Rufus, and sleeps. Emily relies heavily on her sister-in-law. But early in the story, at the Eat’n Park breakfast buffet, Arlene has a stroke, forcing Emily to muster some independence and assume a care taking role. Purchasing a new car on her own is a major milestone for this woman who spends most of her time living in the past, fearing the future, or worrying about her children. Her daughter is a recovering alcoholic with relationship problems. Her son, though dutiful to his mother, is married to a strong woman who doesn’t get along with Emily. All four grandchildren have issues which confound Emily. There’s nothing particularly special about Emily. She’s an ordinary old woman. Yet we all know an Emily, whether she’s a mother, grandmother, great aunt, friend. The author manages to create joy and life in the merely mundane. Because there are so few people left in her life, O’Nan expertly transforms the constants in Emily’s existence, namely Rufus and the city itself, into well-developed characters. O’Nan knows the city of Pittsburgh well and this intimacy fulfills Emily’s need for consistency and familiarity. One might think a book about growing old couldn’t possibly have a happy ending, but O’Nan graciously ends this story with hope and optimism.


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Body-positive singer Lizzo has taken another step in her ongoing campaign to promote acceptance.
Posting a nude shot of herself to Instagram, she wrote, "“If you love me… you love all of me. You dont get to pick and choose. We should be unconditionally loving of one another, starting with being unconditionally loving to ourselves. Take a moment today and think about the conditions we cling to. Free yourself in love. You deserve it.”
Refusing to bow to pressure to slim down, Lizzo is an outspoken advocate for loving yourself and your shape. Last month, she posted a video of herself, captioning it, "“I gained weight. I look TF GOOD.” She accompanied it with nail-painting ('not bothered' and heartface emojis.
She said, "Hey, so I’ve been working out consistently for the last five years, and it may come as a surprise to some of y’all, that I’m not working out to have your ideal body type.
Watch: Lizzo says 'I gained weight', celebrates her figure in new video
“I’m working out to have my ideal body type. And do you know what type that is? None of your f–king business. If you’re not a fat shamer… keep scrolling… OK now that all the fat shamers are here...I am beautiful, I am strong, I do my job, and I stay on my job."
The much-loved star, who is an icon for many, is still affected by criticism - speaking about the 'hate' she receives alongside the love, Lizzo said, through tears, "Sometimes I feel like the world just don’t love me back. It’s like, it doesn’t matter how much positive energy you put into the world. You’re still going to have people who have something mean to say about you."
Her latest post has over 20 000 comments- largely supportive. Singer Erykah Badu posted a string of heartface emojis, while body-positive model Laura Adlington wrote "My Queen". Others commented "living legend" and "Please Lizzo, one dinner date, that's all I ask."
Others praised the star for her advocacy - "If I saw my body type represented more when I was in high school, I feel like s**t could of been so different," said one grateful follower.
Last year, the star, 33, told Good Morning America, "“I don’t mind critique about me, my music. I don’t even mind the fat comments. I just feel like it’s unfair sometimes, the treatment that people like me receive.”
She went on, "People are like, don’t let ‘em see you with your head down. My head is always up. Even when I’m upset and even when I’m crying, my head is up. But I know it’s my job as an artist to reflect at times, and this s**t should not fly. This shouldn’t be ok."
Lizzo added, "Black women have been in this industry and innovating it forever. It is unfortunate that we are the ones who do suffer from the marginalisation the most and the erasure the most and I feel like if it weren’t for the internet, if it weren’t for social media, I could have been erased.”
Lizzo added: “But I chose to be undeniable and I chose to be loud and I chose to be great and I’m still here. It’s difficult.”
It's not the first time Lizzo has posed nude - the cover of her 2019 'breakthrough' album, Cuz I love You. She told an NPR interviewer, "I'm just a little bit more vulnerable than I am ever before. Even my vocal is a little bit more vulnerable.
So I wanted to...show vulnerability and strength on this album - and even to the album cover. Like, you know, being completely naked, but also looking so comfortable with myself, I think, is a testament to this album showing vulnerability and strength."
Watch: Lizzo says she doesn't want to be the face of body positivity
Talking about her body positivity journey, she went on to explain, "ten years ago, I couldn't find a bathing suit, and I couldn't find bikinis for my body size. And I was being told every day that my face was great, but my body needs work.
"I was being shamed in little ways that people didn't even realise they were shaming me. It was so ingrained. And I started to shame myself and actually believed what they were saying to me. And I think about 10 years ago, I made the decision that I just wanted to be happy with my body, and I just wanted to be happy with who I am and that I would wake up every day in the same body, and it wasn't going to change," she explained.
"That was the beginning of my journey with learning how to love my body. And it most certainly didn't end there, and it didn't apex there. Like, I had to work for many, many years to get to this point.
"And I'm still working on it every day. There's days where I wake up and I'm like, oh, my God. You know, this isn't me. But then I have to remind myself, this is you. It looks a little different, but it's still you.
"And you have to find that love for yourself deep down inside."

domain: celebrity


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Come listen and learn from recognised names and pros creating amazing podcast shows around the world. Bringing stories to your ears through audio, these creators are driven by a bona fide purpose. Podcasting is booming and we have selected a highly curated group of speakers to tell their stories and secrets.
For the “Voices of the World” festival, our star line-up includes Dan Snow, creator and mastermind behind History Hit podcast, George the Poet (Have your heard George’s Podcast, Peabody Prize 2020 - Uganda/UK), Ning Yan (A Thousand Whys - China), Lory Martinez (Mija Podcast, Studio Ochenta - Colombia/US), Amit Varma (The Seen and the Unseen - India) and back by popular demand to open up the festival is Tom Morley (ex Scritti Politti - UK), the Rockstar Activator.
You'll get a chance to ask your questions with the speakers as well as interact and network with other podcast enthusiasts.
It all begins at 9:30am EST / 2:30pm British Summer Time / 3:30 CEST / 7:00pm IST on July 15.
This event is for all who enjoy podcasts and podcasters whether newbies or seasoned veterans. If you enjoy and want to get the most out of your podcasts, grab a ticket and get ready for 3 1/2 hours of packed fun, stories and networking.
BTW If you can't attend live, by getting a ticket, you will have access to the REPLAY.


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“Bhaiyaaji Will Be A Raw and Intense Character,” Says Manoj Bajpayee On His New Film —
The production of “Bhaiyaaji” will begin in mid-September, and the filming will take place over a span of 45 days in various locations across Uttar Pradesh. This highly anticipated film starring Manoj Bajpayee is a joint venture between Bhanushali Studios Limited, SSO Production LLP, and Aurega Studios.
Expressing his excitement about this new project, Manoj Bajpayee shares, “I am absolutely thrilled to delve into the world of ‘Bhaiyaaji’. The character I will portray is raw and intense, and I cannot wait to bring it to life. Given the entertaining nature of ‘Bhaiyaaji,’ I decided to collaborate once again with Apoorv Singh Karki, the director of ‘Sirf Ek Bandaa Kaafi Hai,’ and also take on the role of a producer alongside this wonderful team.”
Director Apoorv Singh Karki adds, “Through ‘Bhaiyaaji,’ we embark on a journey to capture the unfiltered essence of our characters within the backdrop of a gripping revenge drama. Our aim is to showcase the power and depth of familial bonds. After exploring the hard-hitting subject matter of ‘Sirf Ek Bandaa Kaafi Hai,’ I wanted to venture into a completely different style of cinema, and ‘Bhaiyaaji’ was the perfect film for that.”
After “Sirf Ek Bandaa Kaafi Hai,” Manoj Bajpayee is set to collaborate with the same team again for the upcoming movie, “Bhaiyaaji”. Manoj Bajpayee will be headlining the film, which is said to have intense action, revenge drama, and heartfelt emotions of family bonding.
Team Bhaiyaaji is set to commence its shoot in mid-September, embarking on a 45-day shooting schedule across Uttar Pradesh. The Manoj Bajpayee starrer will be produced by Bhanushali Studios Limited and SSO Production LLP in association with Aurega Studios.
Talking about this new film, Manoj Bajpayee says, “I am thrilled to step into the world of Bhaiyaaji. It will have a raw and intense character that I am excited to bring to life. As the thorough mainstream entertainer that Bhaiyaaji is, it made me decide to collaborate with Apoorv Singh Karki, who directed Sirf Ek Bandaa Kaafi Hai, and become the producer for this one along with the lovely team.”
“With Bhaiyaaji, we are embarking on a journey to portray the raw and unfiltered essence of the characters against the backdrop of intense revenge drama and showcase the strength and emotions of family bonds. After the hard-hitting subject of Sirf Ek Bandaa Kaafi Hai, I wanted to explore a completely different style of cinema, and Bhaiyaaji was the apt film,” shares director Apoorv Singh Karki.


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I've never been one to be well prepared and have always paid the price when it comes to nutrition. Nutrifix let's me get the convenience of the high street with the balance of a well planned diet.
I struggle knowing what I should be eating for lunch. Nutrifix has taken away that stress by locating the exact meal my body needs. It couldn’t be easier – I love it!
I use Nutrifix when I’m out and about and want to find healthy vegetarian meals. Even better, is knowing the meal is tailored to my needs.

domain: health