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Scientific advancements may be leading to more effective drugs, but the requirement for solubility-enhancing technology, palatability improvements and life-cycle extenders is greater than ever. Susan Birks looks at ingredient trends.
Drug developers around the world are facing a new set of challenges. Not only are the new active ingredients poorly soluble and site-specific, requiring complex delivery systems, but development costs are rising. Add to this the cost of new initiatives such as QbD and the Falsified Medicines Directive and the profitability of new drugs takes a dive. In addition a high failure rate of new drugs and growing use of generics makes lifecycle extensions a priority.
Topping the list of needs for most drug developers, however, is improving solubility and bioavailability. As one ingredient supplier put it, now that all the easy (small) therapeutic molecules have been discovered, the new molecules coming through are much more complex and suffer from solubility and bioavailability issues. As a result, ingredient suppliers and CMOs are focusing their offerings on improving solubility and bioavailability of actives, through either chemical or mechanical methods, or in terms of enhanced delivery vehicles.
As a global provider of pharmaceutical contract development and manufacturing services, Patheon sees improving the bioavailability of poorly soluble new chemical entities as a leading challenge in drug development. According to Ben Bauvalot, Patheon’s Director of Global Marketing, around 40% of new chemical entities fall into class II – low solubility drugs. This makes them ‘tougher compounds to formulate,’ he says.
There are many approaches to solving bioavailability issues and Patheon, like others, aims to offer a multi-pronged approach. Two years ago the company launched SoluPath, described as a cost-effective service to identify an optimal drug delivery system for compounds with poor bioavailability. Through a parallel screening approach of technologies, such as solid dispersions, micro-particles or lipid-based formulations, Patheon’s programme has ‘allowed a consistent three to five times increase in bioavailability and shows 30% save rate for compounds that would have failed due to bioavailability issues’.
With so few new drugs making it onto the market, it is also important for commercial reasons to extend the life span of existing drugs
With so few new drugs making it onto the market, it is also important for commercial reasons to extend the life span of existing drugs, notes Bauvalot. ‘The patent cliff means companies are looking for lifecycle extensions – the combination of one active with another, such as we see in diabetes drugs, for example.’
Patheon is looking to help formulate this type of drug through its expertise in soft gel technology and its new line of softgel solutions – P-Gels – can also be formulated in tandem with the bioavailability enhancing formulation strategies.
Other technologies in Patheon’s armoury are: self-emulsifying drug delivery systems, concentrated micro-emulsion technology, galenic systems that mix hydrophilic and lipophilic phases, or micro-particle technology. The company has also added hot melt extrusion (HME) to the range of technologies utilised by the SoluPath programme.
Dr Matthias Buceris, Head of Pharma Raw Materials at Merck Millipore, also sees bioavailability as a major pinch point in the development of drugs. ‘No single technology fits all the challenges,’ he says. ‘This is why Merck Millipore has built up a portfolio of different technologies for large and small molecules.’
Merck’s silica technology, for example, is seen as a means to achieve life cycle management. The company is the largest producer of chromatography silica and has extensive silica knowhow as well as pharma expertise through being part of the Merck group. The company’s bimodal porous silica is being promoted as a new tool in increasing the solubility of active pharmaceutical ingredients (APIs).
Amorphous silica has been used in oral applications for decades; this latest product comprises particles that contain mesopores for a large surface area and additional macropores for good access to the surface. The drug is dissolved in organic solvent and then loaded onto the surface of the silica particles. After the solvent is completely removed, the drug substance remains on the surface in its amorphous state. This soluble amorphous state is a key factor for improved solubility and the loading process is optimised to achieve it (see Manufacturing Chemist, December 2012, p28-29).
Another key supplier offering help with solubility is Dow Wolf Cellulosics, part of the Dow Company. Its expertise in ingredients has generated a range of renewable, plant-based solutions under its Methocel and Ethocel ranges. The company also offers Polyox products that can help with solubility at several steps in the drug formulation and delivery process. In addition, it has spray dry and HME know-how that can help in dealing with solubility issues.
For elderly patients on a daily regime of drugs, or where medicines are directed at children, palatability and user-friendly formulations are recognised as important in aiding compliance
After solubility, the challenge that is important for many of the molecules being developed is palatability. Many new cancer treatments are made with relatively unpalatable actives. For elderly patients on a daily regime of drugs, for example, or where medicines are directed at children, palatability and user-friendly formulations are recognised as important in aiding compliance with treatment regimes.
With this in mind, the research teams at Cargill have been working hard to prove that ingredients such as its orally dispersible tablet (ODT) excipient, Zerose erythritol, can improve flavour and mouthfeel of unpalatable APIs.
Also working in the area of increasing palatability and user-friendly dosage options, ingredient producer Roquette recently developed a fast disintegrating orodispersible film (ODF) with taste-masking effects as an alternative to tablets, syrups or suppositories.
In a recently published study,1 such an ODF alternative to tablets, syrups or suppositories was developed specifically for treatment of vomiting and nausea in the pediatric population. Roquette’s excipients Kleptose HPB (cyclodextrin) or Kleptose Linecaps (maltodextrin) were used as solubilisers and Lycoat RS 720 (modified pea starch polymer) as a film-forming agent. The result was an ODF of dimenhydrinate that was fast disintegrating even in small volumes of liquid. Furthermore, in vitro taste assessment by two electronic tongues revealed that the excipients showed taste-masking effects.
Companies are looking for better palatability and more user-friendly dosage formats
New quality initiatives
Another major challenge facing the industry is the concept of Quality by Design (QbD), initiated by the industry regulators. This aims to facilitate the design of products and processes that maximise a product’s efficacy and safety profile, while enhancing product manufacturability. As a result of its introduction, companies developing new drugs will, in future, need to prove that their products fit with the concept of QbD – i.e. that they offer better bioavailability, better delivery to the target site, or improved compliance etc.
QbD will have an effect at all levels of process development, says Dr Detlev Haack, Head of R&D, at Hermes Pharma.
‘Pharmaceutical manufacturers will have to show that they have tested and compared different approaches to a drug’s development and chosen the best route and so adhering to the concept of QbD will mean a rise in terms of development costs.’
Among the new formulation challenges arising from QbD suggested by Dr Haack are:
- Making dual tablets to reduce the overall number of tablets needed to be taken.
- Producing effervescent granules – a format that the patient likes to take
- In the case of pain relief, where high doses can be difficult to swallow, turning them into a granulate or soft granulate so that elderly patients can swallow them more easily.
Pharmaceutical manufacturers will have to show that they have tested and compared different approaches to a drug’s development and chosen the best route and so adhering to the concept of QbD will mean a rise in terms of development costs
Hermes Pharma specialises in developing and manufacturing user-friendly solid oral dosage forms, including effervescent and chewable tablets, instant drinks and orally disintegrating granules and it aims to help meet these and other future formulations challenges. ‘Granulation for effervescent products offers high stability and protection of the ingredients,’ says Dr Thomas Hein, Sales and Business Development Director at Hermes. He adds that Hermes has developed several granulation processes, ‘including a continuous flow type process for large volume products’.
Exploiting OTC opportunities
Increasing costs and lower profits in the prescription market mean that pharma manufacturers are also looking for new areas to exploit. Aenova CEO Heiner Hoppmann says he can see more pharmaceutical companies looking at the OTC market because of the lowering of reimbursements by governments, while the food supplement companies are looking toward the pharma OTC market – thus the markets are coming together.
A specialist in solid dosage forms that was created by the merger of Dragenopharma and Swiss Caps, Aenova has a strong focus in the supplement area. Hoppmann says, ‘Alongside our contract development and contract manufacturing portfolio, we will be focusing on our development and production services for effervescent products and our expertise in development of multi-unit-pellet-systems.’
Using innovative technologies, the company manufactures granules and pellets for a wide range of applications. They can be packed into sachets, inserted into capsules, pressed to make conventional tablets or used to manufacture film-coated tablets. The benefits, when compared with other dosage forms, are primarily in the biopharmaceutical field. Depending on the distribution of the active ingredient across various subunits, different reproducible release profiles can be achieved, which enables the bioavailability of the substance to be controlled.
For most suppliers, the days of customers simply selecting ingredients from a brochure and then shipping samples to the customer in the hope that they will do the job are a distant memory. Suppliers are having to work in long-term partnerships not only with drug developers but also with third parties to develop or select the ingredients and technologies that are suitable. An example is the recent collaboration between independent drug-formulation developer and manufacturer, Bend Research and Dow Chemical Company. The collaboration is in science-based spray-dried dispersion (SDD) solutions and select enabling of new polymers for poorly soluble oral drugs.
The two companies will work together to provide the industry with fully characterised polymers supported by QbD principles and the ability to tailor materials to meet the performance needs of specific drugs. They will also develop new materials for SDDs that address technology gaps in manufacturability and delivery, providing better therapeutic performance.
Dow will provide hypromellose and hypromellose acetate succinate, as well as options to tailor these materials, and next-generation cellulosic and noncellulosic polymers for enhanced performance.
The partners believe such collaborations will reduce drug development risk by combining both materials development and optimisation early in the formulation development process for SDDs to achieve optimal clinical outcomes and robust product manufacturing processes.
Dow is fully supporting this collaboration with an array of technologies, including: high-throughput polymer synthesis and API solubility screening; lab-scale product development and structure-property optimisation; as well as a fully cGMP market-development plant capable of supporting clinical development of optimized solution.
New drug delivery technologies are all about making the drugs available to the body and the excipient properties are critical to delivering spray drying
Senior R&D Director for Dow, Bob Maughon says, ‘New drug delivery technologies are all about making the drugs available to the body and the excipient properties are critical to delivering spray drying. To get it right requires a partnership between ingredient supplier and pharmaceutical customer.’
For example, in new process technologies such as SDD or HME, the ingredient has to be tailored to the application. In ongoing developments with customers, Dow has demonstrated the ability to double the throughput in spray drying with improved excipients, and it can help manufacturers on costs and performance too.
‘Employing QbD will also save costs in the scale-up,’ he adds.
Regulatory burden and supply chain security
It is increasingly important for pharmaceutical developers to ensure that they have the all right regulatory information and back up for speedy Market Authorisation. Marc Van Gerwen, Global Marketing and Sales Director, Dow Wolff Cellulosics, says: ‘What we are doing is making sure we have reliability in supply, sample libraries readily available, good case studies, and technical expertise and help available to ensure companies can get the formulation studies done rapidly for the FDA.’
With adulterated ingredients and counterfeit products hitting the headlines, reliability in the supply chain is another big issue. As a result, says Maughon, Dow has sought to provide greater transparency of how it sources and makes products and provides safety assurance, for generics as well as new drugs. ‘Reliability is so important for a low cost [generic] product, so we must have tighter control over the process. We ensure that we have multiple trains that can produce products for consistency of supply and global reach.’
He cites gelatin as an example. ‘Gelatin is an animal product. With hydroxypropyl methyl cellulose (HPMC), a vegetarian alternative to gelatin, Dow can offer more assurance around the quality and the supply chain. In addition, when applying QbD principle HPMC can provide much better product reliability and formulation consistency.’
Just as there has been a step change in drug development, ingredient suppliers are also looking to raise their game and strategic collaborations are becoming vital to solve solubility, palatability and deliverability issues presented new medicines.
1 Preis, M.; Pein, M.; Breitkreutz, J. Development of a taste-masked orodispesible film containing dimenhydrinate. In Proceedings of the 2nd Electron. Conf. Pharm. Sci., 1-31 May 2012; Sciforum Electronic Conferences Series, 2012.

domain: chemistry


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Snoop Dogg gifts Stephen Curry an iced-out Death Row Records chain.
In an Instagram clip, Snoop Dogg wraps the chain around Steph Curry's neck- he says, “had to give the MVP his death row chain @stephencurry30 @deathrowrecords.”
We previously reported that Snoop Dogg purchased Death Row Records back in February. He says, "I am thrilled and appreciative of the opportunity to acquire the iconic and culturally significant Death Row Records brand, which has immense untapped future value. It feels good to have ownership of the label I was part of at the beginning of my career and as one of the founding members. This is an extremely meaningful moment for me.”
He concluded, “I’m looking forward to building the next chapter of Death Row Records.” The label was created in 1992 by Dr. Dre. Steph Curry is all smiles in the video above, so it looks like he's wearing the chain with honor.

domain: celebrity


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Venus Williams falls to Sara Errani
Venus Williams' comeback fell short at the US Open on Friday afternoon, falling to Sara Errani 6-0, 0-6, 7-6 (5).
Man at New York hotel robbed of cash, necklace, police siad
A 45-year-old tourist from Thailand was robbed of thousands in jewelry and cash by a blonde woman he met in a Lower Manhattan bar.
NYPD looking for suspect who inappropriately grabbed women in Brooklyn
Police are looking for a man wanted for grabbing strangers inappropriately in Brooklyn in two separate incidents.
Jesus Montero, scout in altercation
The Seattle Mariners will further investigate an altercation that occurred Thursday between catcher Jesus Montero, currently rehabbing an oblique injury with the team's Class A Everett AquaSox affiliate, and Butch Baccala, a scout from his team.
Jim Irsay reaches plea agreement
Colts owner Jim Irsay has reached a plea agreement in his impaired driving case, the Indianapolis Star reported Friday, citing court officials.
Ndamukong Suh not fined by NFL
Detroit Lions defender Ndamukong Suh was flagged for roughing Jacksonville QB Chad Henne last Friday, but he won't be fined for the play.
President Obama attends fundraisers in Westchester County
Getting around southern Westchester County could be tough Friday afternoon as President Barack Obama arrives on a Democratic fundraising sweep.
Five cuts remain on Rams
Michael Sam survived a round of cuts by the St. Louis Rams on Friday, sources told ESPN.
Military Guns Missing From Police Agencies
The guns-drawn streets of Ferguson jolted America awake to the militarization of the nation's police. Local cops, often untrained in military tactics, may be carrying assault rifles used by our Marines and even Special Forces, using surplus weaponry don..
Tony Stewart expresses sorrow
Tony Stewart expressed sorrow in his first public comments since striking and killing driver Kevin Ward Jr. earlier this month in upstate New York.
Pre-K push underway for 4-year-old students
New York Mayor Bill de Blasio made pre-kindergarten for all 4-year-olds his No. 1 campaign issue, and got $300 million in funding from Albany.

domain: news


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Janssen Submits Biologics License Application to U.S. FDA for Talquetamab for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma
RARITAN, N.J., December 9, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the submission of a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for talquetamab for the treatment of patients with relapsed or refractory multiple myeloma. Talquetamab is an investigational, off-the-shelf (ready to use), bispecific T-cell engager antibody targeting both GPRC5D, a novel drug target that is on some normal cells but overexpressed on myeloma cells, and separately targets CD3 on T cells.
“Despite the therapies that have been developed for the treatment of multiple myeloma, there remains persistent unmet needs for patients who relapse or become refractory,” said Peter Lebowitz, M.D., Ph.D., Global Therapeutic Area Head, Oncology, Janssen Research & Development, LLC. “Through our discovery and development of talquetamab, a novel GPRC5DxCD3 bispecific antibody, we remain relentlessly committed to the investigation of innovative therapies for patients and oncologists. We look forward to working closely with the FDA in their review of the talquetamab submission.”
This BLA is supported by data from the Phase 1/2, first-in-human MonumenTAL-1 study of talquetamab (Phase 1: NCT03399799; Phase 2: NCT04634552) in patients with relapsed or refractory multiple myeloma who have received more than three prior lines of therapy.1 The first presentation of Phase 2 results from the MonumenTAL-1 study will be highlighted at the American Society of Hematology (ASH) Annual Meeting on December 10, 2022 in an oral scientific session (Abstract #157) and featured as part of the ASH Press Briefing.
Talquetamab is a first-in-class, off-the-shelf (ready to use), investigational bispecific T-cell engager antibody targeting both GPRC5D, a novel multiple myeloma target, and CD3, a primary component of the T-cell receptor. CD3 is involved in activating T cells, and GPRC5D is highly expressed on multiple myeloma cells.,
Talquetamab, which is given by subcutaneous injection, is currently being evaluated in the Phase 1/2 MonumenTAL-1 clinical study for the treatment of relapsed or refractory multiple myeloma (NCT03399799), and in combination studies RedirecTT-1 (NCT04586426), TRIMM-2 (NCT04108195), TRIMM-3 (NCT05338775), MonumenTAL-2 (NCT05050097) and MonumenTAL-3 (NCT05455320).
Talquetamab received Breakthrough Therapy designation from the U.S. FDA in June 2022 for the treatment of adult patients with relapsed or refractory multiple myeloma, who have previously received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 antibody. In May 2021 and August 2021, talquetamab received an Orphan Drug designation for the treatment of multiple myeloma by the U.S. FDA and the European Commission, respectively. In January 2021, talquetamab received a PRIME designation by the European Commission.
About Multiple Myeloma
Multiple myeloma is an incurable blood cancer that affects a type of white blood cell called plasma cells, which are found in the bone marrow. In multiple myeloma, these plasma cells change, spread rapidly and replace normal cells in the bone marrow with tumors. In 2022, it is estimated that more than 34,000 people will be diagnosed with multiple myeloma, and more than 12,000 people will die from the disease in the U.S. While some people diagnosed with multiple myeloma initially have no symptoms, most patients are diagnosed due to symptoms that can include bone fracture or pain, low red blood cell counts, tiredness, high calcium levels, kidney problems or infections.
About the Janssen Pharmaceutical Companies of Johnson & Johnson
At Janssen, we’re creating a future where disease is a thing of the past. We’re the Pharmaceutical Companies of Johnson & Johnson, working tirelessly to make that future a reality for patients everywhere by fighting sickness with science, improving access with ingenuity, and healing hopelessness with heart. We focus on areas of medicine where we can make the biggest difference: Cardiovascular, Metabolism & Retina; Immunology; Infectious Diseases & Vaccines; Neuroscience; Oncology; and Pulmonary Hypertension.
Learn more at www.janssen.com. Follow us at @JanssenGlobal and @JanssenUS. Janssen Research & Development, LLC and Janssen Biotech, Inc. are part of the Janssen Pharmaceutical Companies of Johnson & Johnson.
# # #
Cautions Concerning Forward-Looking Statements
This press release contains “forward-looking statements” as defined in the Private Securities Litigation Reform Act of 1995 regarding product development and the potential benefits and treatment impact of talquetamab. The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Janssen Research & Development, LLC, Janssen Biotech, Inc., or any of the other Janssen Pharmaceutical Companies and/or Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; manufacturing difficulties and delays; competition, including technological advances, new products and patents attained by competitors; challenges to patents; product efficacy or safety concerns resulting in product recalls or regulatory action; changes in behavior and spending patterns of purchasers of health care products and services; changes to applicable laws and regulations, including global health care reforms; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson’s Annual Report on Form 10-K for the fiscal year ended January 2, 2022, including in the sections captioned “Cautionary Note Regarding Forward-Looking Statements” and “Item 1A. Risk Factors,” and in Johnson & Johnson’s subsequent Quarterly Reports on Form 10-Q and other filings with the Securities and Exchange Commission. Copies of these filings are available online at www.sec.gov, www.jnj.com or on request from Johnson & Johnson. None of the Janssen Pharmaceutical Companies nor Johnson & Johnson undertakes to update any forward-looking statement as a result of new information or future events or developments.
 Pillarisetti K et al. Blood. 2020;135(15):1232-1243.
 Chari A et al. Talquetamab, a G Protein-Coupled Receptor Family C Group 5 Member D x CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma (RRMM): Phase 1/2 Results from MonumenTAL-1. American Society of Hematology 2022 Annual Meeting. December 2022.
 Labrijn AF et al. Proc Natl Acad Sci USA. 2013;110:5145.
 Cohen, Y., et al. Hematology. 2013 Nov; 18(6):348-51.
 National Cancer Institute. Plasma Cell Neoplasms. Accessed September 2022. https://www.cancer.gov/types/myeloma/patient/myeloma-treatment-pdq.
 American Cancer Society. “Key Statistics About Multiple Myeloma.” Available at: https://www.cancer.org/cancer/multiple-myeloma/about/key-statistics.html#:~:text=Multiple%20myeloma%20is%20a%20relatively,men%20and%2015%2C370%20in%20women). Accessed September 2022.
 American Cancer Society. “What Is Multiple Myeloma?” Available at: https://www.cancer.org/cancer/multiple-myeloma/about/what-is-multiple-myeloma.html. Accessed September 2022.

domain: medical


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What's New > New Cinema Division Representative
November 25, 2015
The Groupe Spectre Sonore is proud to announce that Denis Lévesque is joining our team as the new cinema division representative. He will be happy to meet you in his new capacity to help you realise your projects, whether big or small. you can reach him as of now via his email or by cell phone 514-833-6939.
Visit us at www.spectresonore.com
Toll free 1-877-443-9260
GO TO ALL NEWS →
GO TO RECENT FORUM POSTINGS →
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front page is cool
And all this time we never knew...
the world is a place full of mysteries
Your my hero.
Loved it from the beginning to the end! >:D
The squirrel was my favourite :)
The squirrel is cool
excellent, very good.
hahaha thanks :<>
dude that was awsome lol! i love the ending that was great! so does mrs. clause dress like a man when she's alone? ;/
Pilot for my new show!
A story about a worm, a beetle and a very hungry bird…
New video for you to watch, while we wait for the next plague to happen...
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domain: artistic


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Tavian Bryant – The Journey to 40 and BeyondTavian Bryant
This whole journey started about 5 years ago. I had been in a wheelchair for 18 years at this point. I was out of shape and needed to do something about it. I also wanted to get out there and feel myself in the wind as I did before, riding bikes and motorcycles in my youth. I bought a handcycle shortly after my injury, and I rode it from time to time. However, it mostly sat in my garage collecting dust. I even tried a marathon early on, but it didn’t pull me in at that point. The timing just wasn’t right. I was figuring out too many things at the time to give my attention to the bike. I was learning how to live with a spinal cord injury, and going to college. Not long after that I was starting a family and becoming a high school teacher. With all of that going on I just didn’t really think much about riding the bike. Well as I said, about 5 years ago life started to slow down a little bit and I rediscovered the bike. As time went on I found myself riding more and more. I noticed I was becoming faster, and feeling stronger. I decided to enter a few more marathons, and it became fun as I was able to test my mental and physical limits as well as compete against other handcyclists. The physical activity and competition was definitely something that I needed. I decided to set a goal to complete 40 marathons to challenge myself. I really don’t know where the number came from. It just seemed like a number that would be a challenge, but also something I could realistically achieve in time. I shared my goal to complete 40 marathons with my family, friends, co-workers, and my students as I started to move through the journey. As time went on, more and more people were asking about my progress, and the next marathon on my schedule. Along the way I’ve had so many people tell me that my journey to 40 has inspired them. I never really planned it that way. I was just out there trying to get in shape and challenge myself. I had the desire to live an extraordinary life and not let the injury define me. The fact that I’ve been able to have an impact on the lives of others through this process has in turn inspired me to do more in so many areas of my own life. You never know what something can turn into until you get started. This whole process has changed my life. I’m healthier, I’ve met a bunch of great people, and traveled to places I most likely wouldn’t have if the bike hadn’t taken me there. I have completed 36 marathons to date. The bike has taken me to 10 states so far. I’ve competed in a road race, completed a marathon or just rode my bike in Arizona, Idaho, Montana, Nevada, California, Massachusetts, New York, Georgia, South Carolina and Utah. Honestly, I hope to ride my bike in all 50 states before my final turn of the crank. The highlights of the journey are the Boston Marathon, The New York Marathon, and the Los Angeles Marathon. For the final 4 marathons I hope to get to: Houston Marathon – Texas Marine Corps Marathon – Virginia Air Force Marathon – Ohio The Miami Marathon – Florida. But it won’t stop when I hit the goal. I’ll just keep going, and going, and going. If you have been following my journey from the beginning you may have noticed that the pace at which I’m completing marathons has slowed down a bit. There’s a reason for that. I’ve found a new challenge. While competing in marathons, I discovered a handcycle racing circuit that hosts races all over the country. I competed in my first handcycle road racing series a few years back and have been hooked ever since. These road racing series usually consist of 3 or 4 individual racing events over a 3 or 4 day period. So for the last couple years I’ve been splitting the time between road racing series and marathons, which has slowed my marathon completion pace. I still intend to complete my goal of 40 marathons, but the pace will be a little slower. As I pursue new goals, my focus and priorities have shifted more toward the road racing series than the marathons, here’s why. The United States has a handcycle team that races at events all over the world. Members of that same team also have the opportunity to race in the Paralympics, which happens on the back end of the Olympics. I have no idea if I’ll ever improve enough to earn a spot on that team, but I’m going after it. As you can see I’ve found something bigger. It has become my next challenge, and a new journey has started. I found out about a handcycle team, (TeamPossAbilities) applied, and was selected to be a member of the team. Being a member of TeamPossabilities has allowed me to take handcycle racing to another level. The support and encouragement of TeamPossAbilities administration has given me the opportunity to race a full season and access professional coaching (Rick Babington). In addition to that, the competitiveness and assistance of my PossAbilities teammates has helped me gain valuable race experience and make real progress over the last 18 months. As I said before I’m not sure where I will end up, and I have a long way to go, but I’m up for the challenge. I suffered a spinal cord injured 23 years ago. If you would have asked me what my life would look like today I would have never imagined in a 1000 years that I would be in this position and would have been there and done that, and have this story to tell. I thank God for every part of this experience, the easy parts and the tough ones too. I’m better and stronger because of it. I also want thank everyone who has supported me throughout this incredible journey. It seems as though it is just getting started and there are exciting things to come.

domain: sports


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Impact of a Health Promotion Intervention on Maternal Depressive Symptoms at 15 months Postpartum
- First Online:
- Cite this article as:
- Surkan, P.J., Gottlieb, B.R., McCormick, M.C. et al. Matern Child Health J (2012) 16: 139. doi:10.1007/s10995-010-0729-x
- 964 Downloads
Given that diet, physical activity, and social support are associated with depression, we examined whether a health promotion intervention designed to modify these factors in low-income, postpartum women would reduce depressive symptoms. This study used a randomized, controlled design to examine the effect of the Just for You (JFY) Program, an educational intervention promoting healthy lifestyles through home visits by nutrition paraprofessionals and motivational telephone counseling, on postpartum depressive symptoms. A total of 679 women income-eligible for the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) were recruited at 6-20 weeks post delivery and randomized to Usual WIC Care or JFY. Using an intention-to-treat analysis, the authors modeled depressive symptoms on the Center for Epidemiologic Studies Depression Scale (CES-D) among 403 women (59%) completing follow-up at a mean of 15 months infant age, adjusting for baseline CES-D, age, household income and randomization strata (body mass index (BMI), race/region). As a secondary analysis, the authors evaluated potential mediators related to social support and self-efficacy to change one or more health behaviors targeted by the intervention. Women randomized to JFY reported 2.5 units lower CES-D score (P = 0.046) compared with those receiving Usual WIC Care alone. This relationship was attenuated by change in self-efficacy (β = −2.3; P = 0.065), suggesting this construct may partially have mediated the effect of JFY on maternal depressive symptoms. A health promotion intervention delivered through home visits and telephone calls can reduce depressive symptoms at 15 months postpartum among low-income, ethnically diverse women.

domain: literature


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Petite and heavy Art Deco bedside table lamp with a bent aluminum base. One side of the aluminum is polished and the other side is painted black. Wired and in working condition. Uses a clip-on shade, not included.
Tall mercury glazed ceramic table lamp in dark
bronze with a red lacquered wood base. The lamp has polished brass hardware, felt lining, and a red faceted glass finial. Wired and in working condition. Lamp is 24"H to top of ...


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Vegan group's advert wrongly linking cow's milk to cancer gets UK ban
A vegan group's "misleading" advert linking cow's milk to cancer has been banned.
The poster by activists Viva! triggered two complaints to watchdogs after being seen on buses in Bristol last September.
The ad was banned following an investigation by the Advertising Standards Authority (ASA) because Viva! was unable to substantiate claims that hormones in cow's milk are linked to cancer.
The ad featured an image of a cow's udder and included the claims "Some dairy industry facts we bet you don't know … Most cows are pregnant when milking. That's why milk contains 35 hormones, including oestrogen … some of these are linked to cancer. Milk is for babies, so let Viva! wean you off the teat!"
Two people complained to the ASA that the ad's claim "milk contains 35 hormones, including oestrogen … some of these are linked to cancer" implied that drinking cow's milk could cause cancer, was misleading and couldn't be substantiated.
Viva! said the claim referred to hormones that were naturally occurring in cow's milk, which increased during pregnancy and were essential for calf development.
The campaign group said the claim did not refer to hormone treatments or artificial hormones.
Viva! highlighted that the ad stated the hormones were "linked to" cancer, rather than that they "caused" cancer.
In support of the claim, they referred to a range of papers, which they believed showed the presence of more than 35 hormones in cow's milk, including oestrogen hormones and insulin-like growth factor (IGF-1).
But the ASA found that the poster breached rules regarding misleading advertising and substantiation, and banned it from appearing again.
An ASA spokesman said: "While the claim stated that some hormones in cow's milk were "linked" to cancer rather than definitively stating that they caused cancer, we considered that consumers would nonetheless interpret it to mean that because of the hormones that were present in cow's milk, drinking cow's milk could increase a person's risk of developing cancer.
"We considered that the various sources provided by Viva! constituted adequate evidence that over 35 hormones were present in cow's milk.
"However, we were concerned that the studies were unable to account for confounding factors which could affect the results.
"We also noted that the papers referred to other conflicting evidence and all noted the need for additional studies to confirm their findings.

domain: biology


text:
In May of 2006, the saga of Lake Highlands’ Muffin Men was a national story, from network news to late-night talk shows. A year later, Advocate Magazine recalled the day marijuana-laced muffins were delivered to the LHHS teachers lounge through the eyes of Miss Rita Greenfield, the 87-year-old school office worker who spent a night in the hospital after enjoying two tainted treats. Now, finally, the mother of one of the boys has written a book and told the story from her perspective – as a mom trying to hold her family together.
Caroline Walker changes the names of the boys in her book, available only for Kindle on Amazon and entitled Epiphany in Ordinary Time, but the story is fresh enough and has been written about enough here in LH that it seems silly for me to pretend not to know it. Her son, Ian, is called Niall in the book, and she focuses more on him and on her own family’s ways of getting through the ordeal than on the role of Joey Tellini (called Matt in the book), who cooked up the idea of the muffins and asked his friend to deliver them.
Caroline tells the head-spinning story of watching her beloved, honor student, Eagle Scout son face meltdown just as his life was beginning. Knowing that his troubles were of his own making didn’t make things easier for the mom who’d spent 18 years raising him up. By the time their family life became a maze of criminal lawyers and FBI agents, she admits she wasn’t sure how any of them would get through it.
Today, both boys are University of Texas honor graduates and Caroline has gained some perspective. She hopes other moms whose kids face difficulties can find strength (and, yes, even humor) in her experience.
You can download Epiphany in Ordinary Time for just $2.99 to your Kindle here. It’s worth much more than that price just to read chapter 7, in which LHHS principal at the time, Dr. Bob Iden (who’s name is also changed), graciously welcomes the Walkers into his office to accept the boy’s written letter of apology. Dr. Bob surprises them with his kindness (Caroline admits she’s never set foot inside a public school) and won’t let them leave without meeting Miss Rita. When Miss Rita opens her arms wide and offers a hug, Caroline melts into her “like butter on a baked potato.”
If you thought you knew this boy, if you’d already judged this mom, Caroline Walker gives you a chance to think again.

domain: library


text:
I don’t know about you but I don’t want anything on my kitchen counter that isn’t nice to look at or functional. This cool fine art sculpture is also a container. It will hold your dry coffee bags, (not loose coffee-too messy) or the individual “K” cups. Of course he doesn’t have to be limited to the kitchen, just anywhere you want a statement piece to show off your awesome taste in art.
Handmade with my own little fingers in clay. He has been underglazed and fired. Then a clear glaze is applied and it is fired again.


text:
Newdelhi:18/5/22:Union Minister of State for Health and Family Welfare, Dr. Bharati Pravin Pawar today launched National Emergency Life Support (NELS) courses for doctors, nurses and paramedics. Apart from the training modules, the program also includes developing training infrastructure in all States/UTs to implement the NELS course and creating a cadre of trainers to train doctors, nurses and paramedics working in emergency departments of the hospitals and ambulance services.
The Union Minister of State said that till now, health care professionals in the country had to rely on foreign modules and paid courses which were not only expensive but were also limited in scope to a handful of emergencies without considering needs and priorities of our population landscape. “Therefore, realizing the Hon’ble Prime Minister’s policy of ‘Make in India’ and ‘Atmanirbhar Bharat’, the NELS provides standardized curriculum which is based on Indian context and developed in India”, she stated.
Dr. Bharati Pravin Pawar highlighted that the Government is committed to continuous strengthening of delivery of Covid-19 and non-Covid essential health services, with the medium to a long-term goal of enhancing preparedness capacities to manage medical emergencies and thus minimize loss of precious lives. She stated that “Hon’ble Prime Minister, Shri Narendra Modi ji has always emphasized providing affordable and best quality health services to the citizens. It is the need of the hour that India embarks on creating a world-class, efficient, professional and integrated system, enabled by technology, for the care of any victim of an accident, emergency, or trauma in any part of the country.” Talking about the National Health Policy of 2017, she said that it envisaged the creation of a unified emergency response system, linked to a dedicated universal access number, with a network of emergency care, provision of life support ambulances and trauma management centers.
Dr. Bharati Pravin Pawar further added, “To keep pace with technological advancement advancements, parallel efforts are needed for human resource development by equipping doctors, nurses and paramedics working in emergency departments of hospitals. The training should also be imparted to those providing pre-hospital care with standardized life-saving skills, to minimize mortality due to all types of medical emergencies in the country.”Shri Rajesh Bhushan, Union Health Secretary, Prof. Rajesh Malhotra, Head of Orthopedics & Chief, JPN Trauma Centre (AIIMS), Dr Atul Goel, DGHS and other senior officials from Ministry of Health and Family Welfare were present in the meeting.


text:
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domain: entertainment


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The FUS Foundation’s Research Awards Program received a record number of applications during the first half of 2011. By the end of the second quarter, the Foundation had received 15 proposals, eclipsing the whole-year totals of 11 and 14 for 2009 and 2010, respectively. “It’s incredibly exciting news for the Foundation,” says Hannah Edelen, Director of Research and Fellowship Programs.
Edelen attributes the rise to the Foundation’s change from a rolling acceptance policy to a quarterly deadline system that encourages researchers to submit proposals sooner.
The number of applicants has increased steadily since the Research Awards Program’s inception in 2007.
This growth is important because the program, which generally provides awards of $100K for a one-year period, has filled a funding void for MR-guided focused ultrasound researchers by providing “seed money” for highly promising studies. Funding enables researchers to compile the preliminary data required for the more substantial grants — from government agencies and other sources — needed to move their work toward clinical reality.
Edelen believes that the upward trend in proposals is also an indication of the solid growth in the field of MR-guided focused ultrasound research. The increase in proposals also allows the Foundation to be more selective in the projects it chooses to fund, ultimately making a FUSF Research Award more prestigious for researchers as they seek future resources.
“There has been a clear explosion within the community in terms of the number of researchers doing work in this area. It’s been remarkable to see how much the research has expanded in such a short period of time,” she says.
The Research Awards Program passed the $2 million funding milestone in June. Though most proposals have come from the United States, researchers from Europe, the Middle East and Asia have also applied.
Researchers interested in applying for a FUSF Research Award can click here to find out more about submission guidelines. The next deadline is October 1, 2011.


text:
Sinking under the weight of bank debt, the City of Tonawanda's funky Old Man River restaurant is sending out an SOS to potential investors.
Chuck Miano, owner of the popular glorified hot dog stand, said Thursday that he would close the 19-year-old establishment at the end of business today to concentrate his efforts on securing investment partners.
"It's do-or-die time for me," Miano said. "I've got to find investors by Nov. 13 or I lose it all. I'm working feverishly to avoid that."
Miano faces foreclosure by KeyBank, which has scheduled an auction for 10 a.m. Nov. 13 in an effort to recoup an undisclosed amount of debt.
The restaurateur finds himself in a situation that is all too common in the small-business world: The success of his original restaurant led him to expand. Unfortunately, as Miano now knows, it is not always possible to duplicate success at a new address.
In this case, Miano and family members opened additional Old Man River restaurants on Transit Road in Lockport and on Niagara Falls Boulevard in the Town of Tonawanda. Although both of those satellite locations are now closed, the costs associated with launching them have not gone away.
"We over-invested; we put a ton of money in and didn't get a ton of money back," Miano said. "The saddest part is that debt has been dumped at this doorstep."
The restaurateur had been negotiating with KeyBank for more than a year to find a way to repay an undisclosed amount of expansion debt, but the parties were unable to come to terms.
"They dropped the hammer on me," he said. "Now, my only hope of keeping Old Man River is to find some partners, and quick."
Miano said he has been in discussions with "some serious prospects" to help him bail out the business. Unfortunately, with the foreclosure auction just two weeks away, he is running out of time to find backers.
"It just kills me. I've got a line of customers out the door right now," he said. "I better be
able to pull a rabbit out the hat."
Chuck Anderson of Anderson Auction & Realty described the place as a "true landmark. Everybody's eaten at Old Man River. Unfortunately, he's saddled with the debt from his other locations."
The auctioneer said that if Miano is not able to save the business before the auction date, he expects that the sale will attract a number of serious bidders.
"He's got a tremendous location overlooking the Niagara River. There's a lot of restaurant people who will be giving it a look. It's a prime spot," he said.
Miano and his brother, Sam, opened Old Man River in 1978 with the idea of creating a carefree, lighthearted dining atmosphere reminiscent of the post-World War II years. Both the decor and menu reflect the whimsical attitude the Mianos intended.
One of the eye-catching decorations is what Miano calls the "Fallserator" -- a barrel-like contraption attached to canoes, which appears banged-up enough to actually have carried the restaurant's namesake character, "Old Man River," and his sidekick, "Sully," over Niagara Falls.
The menu is similarly unusual, a place where all-beef hot dogs share space with Old Man River's patented "Bunny Dog," a steamed and char-broiled carrot, served on a hot dog roll.
At Old Man River, customers order heaps of sweet potato fries at nearly the same frequency as do for their pale cousin, the french fry.
Another of the many longtime oddities is the "Liver Burger," a stack of char-broiled liver slabs piled on a hamburger bun. Just this year, the "Frickle" (a deep-fried, breaded wedge of dill pickle) made its debut.
"We've tried to keep things interesting," Miano said. "The ideas just keep coming."


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This study examines the space-time structures of anomalous cloud water content and radiative heating profiles associated with northward propagating BSISO for the period 2006-10. The observation data used in this study includes satellite-observed daily precipitation from TRMM7, cloud ice and liquid water contents from CloudSat Radar-only Cloud Water Content Product (2B-CWC-RO), broadband heating rate profiles calculated consistently with the cloud liquid- and ice-water content estimates from the CloudSat Profiling Radar (2B-FLXHR-LIDAT_P2_R04: L’Ecuyer et al. 2008), and the height-pressure relationship from the ERA-Interim reanalysis. Based on the daily precipitation data, 17 Strong northward propagating BSISV events are identified for the 5-year period 2006-10, with nearly the same northward propagating features as in Jiang et al. (2011). The latitude-height structure of the composite liquid and ice cloud water content anomalies for the 2008-10 period used in this study is nearly the same as that for the 2006-08 period in the Jiang et al. (2011) study. The latitude-height structure of the composite radiative heating anomalies are characterized by: (1) Positive (negative) SW heating anomaly maximum in the upper troposphere, approximately in the location of the positive IWC concentration maxima (low troposphere), (2) Shallow LW cooling anomaly in the upper troposphere at 200hPa, and (3) LW heating anomaly maxima in the lower troposphere. The positive SW heating anomaly in the upper troposphere indicate enhanced absorption of insolation by increased ice clouds in the upper troposphere. The negative SW heating anomaly in the lower troposphere may result from shading of enhanced upper tropospheric ice clouds and lower tropospheric liquid clouds. The positive LW heating in the lower troposphere may result from the enhanced downward LW fluxes from the positive anomalies of the upper tropospheric IWC and the LWC anomalies in the mid- and low troposphere. The net radiative heating anomalies (i.e., LW + SW heating anomalies) show a positive heating anomaly of 0.3-0.4 K day-1 in the upper troposphere and negligible radiative heating in the low troposphere.


text:
Behavior Support (Teachers' Guides)
Product ID : 44940920
Galleon Product ID
No price yet.
Price not yet available.
The revised and expanded edition of a popular book trusted in classrooms across the country, Behavior Support is your guide to implementing effective positive behavior support (PBS)—both in the classroom and across an entire school. You'll get explicit, research-based strategies for implementing the three tiers of PBS: universal, school-wide interventions; selected interventions with students exhibiting risk behaviors; and specialized interventions with students who need intensive, individualized help. Packed with updated strategies on hot topics, redesigned forms, and the newest research on multitiered systems of support, this new edition will help you support positive changes in your students' behavior—so you can keep the focus on learning. (Ideal for both in-service teacher training and college and university courses!) RESEARCH-BASED STRATEGIES FOR HELPING STUDENTS: Stop challenging behavior before it startsImprove communication, social, and self-control skillsForm positive, respectful relationships with classmates, teachers, and other community membersTake a more active part in their school, classroom, and community WHAT'S NEW: More research and strategies on key topics, including bullying prevention, safe and responsive school climates, functional assessment, and individual student interventions. You'll also get more explicit step-by-step instructions, new case examples, tips on sustaining PBS in your school, redesigned forms that are practical and easy to use, and focusing questions for each chapter that highlight key takeaways. This revised and expanded edition is your guide to implementing effective positive behavior support. Includes more on bullying prevention, safe and responsive school climates, and functional behavior analysis.

domain: psychology


text:
Movies can have the ability to act like time capsules of a specific time and place. I can watch “All the President’s Men” and have a window on the frustration and uncertainty of the 1970s or watch “Wall Street” and get a peek at the yuppie era at its pinnacle. “The Social Network” may well be cut from the same cloth. Twenty years from now people born today may look at it and go, “Oh, that's what it was like.”
Some will be quick to dismiss this as the Facebook movie, but they'd be wrong to do so. This isn't some movie of the week chronicling the creation of one the Internet's most popular and successful social networking sites. Oh, you get that back story, but you also get an incisive character study of a very particular type: the smartest guy in the room who is too smart for his own good.
There is substantial talent behind this film. The screenplay is by Aaron Sorkin, the man behind the TV series “The West Wing” and movies like “A Few Good Men,” “The American President” and “Charlie Wilson’s War.” Sorkin, a sharp, observant, witty writer who populates the script with choice lines, treats this material with same amount of depth and substance as his work dealing in politics.
The director is David Fincher, whose resume includes such explorations into the darker side of humanity as “Seven,” “Fight Club” and “Zodiac.” There may not seem to be anything ominous about the creation of Facebook, but Fincher's direction adds a certain menacing undertone as the popularity of Facebook spreads and co-founder Mark Zuckerberg gains power.
Jesse Eisenberg stars as Zuckerberg, the Harvard undergrad who was the creative force behind Facebook. The film is structured as a series of flashbacks told from two intertwined depositions for lawsuit trials. One involves Zuckerberg's co-founder (Andrew Garfield) being pushed out of the company and the other a set of twins (remarkably and seamlessly both played by Armie Hammer) who claim Zuckerberg stole their idea for what would become Facebook.
Eisenberg has played his share of awkward motor-mouthed nerds in movies like “Zombieland” and “Adventureland.” He has mastered the likable nebbish. It is remarkable that Woody Allen hasn't cast him in one of his films yet. But while his work in “The Social Network” is a variation of that persona, there's something more unsettling about Zuckerberg.
As portrayed in the film, he is a coldly intelligent elitist, who talks fast, but not nearly as fast as he is thinking. In nearly every shot of Eisenberg you can sense that his mind is constantly going and that he can't be bothered to slow down to explain himself to lesser mortals.
In the nearly 10-minute opening scene, Zuckerberg's condescending conversation with his girlfriend (Rooney Mara) leads to him being dumped. The film contends it was this rejection that fueled the creation of Facebook.
The unexpected wild card of the film is pop star-turned-actor Justin Timberlake as Napster co-founder Sean Parker. Parker's Internet phenomenon blew up in his face, so, at least according to the film, the minute he heard about “thefacebook” he
immediately set out to weasel his way into a piece of the action.
Timberlake doesn't make his first appearance until late into the film, but he ups the ante. What may seem like stunt casting on paper is anything but. This is a real, full performance. Timberlake oozes confidence, but there's a calculating underlying sinisterness to his charm as he manipulates Zuckerberg against his co-founder. It is a strong performance that matches Eisenberg's exceptional work.
With “The Social Network,” Fincher and Sorkin dare to make a film where the protagonist isn't likable, yet in spite of Zuckerberg's unpleasant attributes, Eisenberg doesn't make him an entirely unsympathetic character.
Late in the film as dirty deals begin to unfold, there's a moment where Eisenberg allows for an unspoken moment of regret that is palpable. The film's final moments show a man worth billions of dollars, but with no friends. This is no spoiler because it is how the film shows this moment that is poetically perfect.


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text:
There are 3 ways to get from Zagreb to Trieste by bus or car
What companies run services between Zagreb, Croatia and Trieste, Italy?
FlixBus operates a bus from Zagreb to Trieste twice daily. Tickets cost $14 - $23 and the journey takes 4 h. Four other operators also service this route.
Bus from Bregana to Trieste
- Ave. Duration
- 3 h 8 min
- Once a week
- Estimated price
- Schedules at
Want to know more about travelling around Italy
Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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Questions & Answers
How far is it from Zagreb to Trieste?
The distance between Zagreb and Trieste is 171 km. The road distance is 231 km.
What is the cheapest way to get from Zagreb to Trieste?
The cheapest way to get from Zagreb to Trieste is to bus which costs 113 kn and takes 5 h 30 min.
What is the fastest way to get from Zagreb to Trieste?
The quickest way to get from Zagreb to Trieste is to drive which takes 2 h 24 min and costs 210 kn - 310 kn.
Is there a direct bus between Zagreb and Trieste?
Yes, there is a direct bus departing from Zagreb and arriving at Trieste. Services depart twice daily, and operate every day. The journey takes approximately 4 h.
How long does it take to get from Zagreb to Trieste?
The bus from Zagreb to Trieste takes 4 h including transfers and departs twice daily.

domain: geography


I'm in an irritable mood at the moment so I am going to make the video short and sweet. Part of conceal carrying is training with your weapon. For about a year now I have relied on Galco's tuck n' go holster, which has served my Bersa Thunder 380 plus nice. However, I am running into a very, very important issue that could get me killed.
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It seems that the life span is up on this little sucker- it can't retain its shape. It will hold my gun, but in a situation where I need to reholster my gun quickly- it could mean that I get shot by police or someone else who mistakes me for the bad guy.
This level of quality is unacceptable for my everyday carry system. I will be looking for a higher quality holster for my Bersa Thunder 380 plus. The problem is is that they are very difficult to acquire for my particular model.


Mar 14, 2018
By Jane Brown
He was described as the greatest scientist since Albert Einstein.
Stephen Hawking has died peacefully at his Cambridge, England home at the age of 76.
Hawking was the best-known theoretical physicist of his time.
His body was attacked by ALS when he was 21, but Hawking went on to live with the usually fatal illness for 55 years while using a computer to communicate his thoughts.
In a 2010 interview with ABC’s Diane Sawyer, Hawking explained why he did not believe in God or religion.
“When you look at the vast size of the universe, and how insignificant and accidental human life is in it, that seems most implausible,” Hawking explained.
Hawking became a scientific celebrity through his theories on black holes and the nature of time. His early life was chronicled in the 2014 film The Theory of Everything, with Eddie Redmayne winning the best actor Oscar.
Stephen Hawking had a Canadian connection. In 2008, he elevated Canada’s profile in the physics community when he accepted a research post at the prestigious Perimeter Institute for Theoretical Physics in Waterloo. He visited the facility in the summer of 2010 and again in 2012.
In a video conference prior to his visit, Hawking said the institute’s chosen focus on quantum theory and space-time was close to his heart.
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A murmur like sound is accounted for to have originated from one of the sold-out iPhone 7 Plus gadgets, with Apple quickly presenting a substitution.
It has been accounted for that the new iPhone 7 Plus is discharging commotion from its rationale board, bringing about a murmur like murmuring getting louder if the telephone is under burden, 512 Pixels has said.
As indicated by the blog entry’s creator Stephen Hackett, the murmur is sufficiently uproarious to be heard regardless of the fact that the iPhone is face-up on a work area.
Hackett said he first heard the sound after he was reestablishing the new gadget from an iCloud reinforcement. Having known about others encountering comparative issues with past iOS gadgets, Hackett said it is the main iPhone for which he has raised a worry identifying with murmuring.
Subsequent to reaching Apple, the tech mammoth is supplanting Hackett’s gadget.
The first iPhone began with 4GB of capacity, while the highest point of-the-extent iPhone 7/7 Plus now offers 256GB of capacity.
The iPhone 7 likewise highlights a 4.7-inch Retina HD show, quad-center A10 Fusion processor, 7-megapixel FaceTime HD front-confronting camera, 12-megapixel back camera with 6-component focal point, a non-physical Home catch including Force Touch input, and water-and clean sealing to IP67 standard.
The iPhone 7 Plus accompanies a 5.5-inch Retina HD show, quad-center A10 Fusion processor, two 12-megapixel wide-edge and fax cameras with 2x optical zoom, a non-physical Home catch highlighting Force Touch criticism, and water-and clean sealing to IP67 standard.
Apple revealed the new iPhones on Wednesday in the United States, with a standout amongst the most eminent changes to the handset the expulsion of the earphone jack, with Apple to now interface earphones over Lightning, which is currently utilized for force, sound, and control.
“Some have inquired as to why we would expel the simple earphone jack from the iPhone. It has been with us quite a while,” said Apple’s advertising boss Phil Schiller.
“The motivation to proceed onward boils down to single word: Courage.”


text:
What are the Audials Chart Toppers for each Genre? Which Artists are on Fire in Audials?
The charts received a more important position in the Audials generation 2018. The weekly new charts are available at a glance in the dashboard and the entirety list of charts can be seen in the Music Wishes tab.
Import Music Wishlists for Audials One, Audials Music Rocket and Audials Radiotracker
To import the tracks you want, simply start Audials One or Audials Radiotracker. Then open the Audials Community via the following link and then click the wishlist you want. With that single click you can download, import and fulfill your wishlists right in the Audials software.
US Single Charts Audials Import
Musicvideo Charts Audials Import
Pop Music Charts Audials Import
Rock Charts Audials Import
70's Charts Audials Import
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With Audials, you Get Your Favorite Radio Stations from All Over the World
This Internet radio station claims to be the “world’s chillout channel”. It broadcasts downtempo, electronica and chillout music from artists, who get little airplay on traditional radio channels like the emerging electronic artists Rufus Del Sol, Patrick Baker, Satin Jackets, Pablo Nouvelle and so on. The channel is free of advertising and plays music selected by people, not computer algorithms.
Listen to Chilltrax
The radio has only been launched in Spring 2017. Music from the 70s, 80s, 90s, 00s and 10s. It claims playing “the Music You Want to Hear”.
Listen to Atom Radio
The radio station without commercials broadcasts classical music, a variety of French retro music and the greatest hits of accordionists of yesterday and today. It is the first Web radio that plays this kind of music.
Listen to Radio Accordéon
Wishlists Including the Top Artists to Download
From now on the Audials Informer provides you every month with a late-breaking overview of the top artists that are represented frequently within the Audials Community Wishlists. But that's not all: with one single click on your favorite artist of these top ones, you get all wishlists in which his or her songs are contained. With just one more click you can easily download, import and let them fulfill with your Audials Software.


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Photo Credit: Getty Images / Jon Kopaloff / Stringer
Janet Jackson took to Twitter to speak out in the name of George Floyd and the many other black men and women who have lost their lives at the hands of police officers.
In her tweet, she says; “We are a nation with no geographic boundaries, bound together through our beliefs. We are like-minded individuals, sharing a common vision, pushing toward a world rid of color lines.” The post was accompanied by a video of the Rhythm Nation imagery and names of numerous black victims who’ve died as a result of police brutality.
Jackson has been active on social media in the wake of Floyd’s death, on Friday (June 5), she posted a #SayHerName tribute on what would’ve been the 27th birthday of Breonna Taylor, the EMT killed by Louisville police in March when they stormed in her apartment on a “no-knock warrant” and shot her eight times after her boyfriend fired at what he believed were intruders.
Check out the post below:
— Janet Jackson (@JanetJackson) June 7, 2020

domain: sociology


The Original Moving Rorschach Inkblot Mask
- First developed by us in 2009, these temperature sensitive masks feature animated inkblots that react to the heat of your breath.
- 100% non-toxic spandex-blend hood conforms to the contours of your face without revealing your features.
- Practice directional breathing to master manipulation effects in different areas.
- Hand clean only. Cold water. Do not bleach. Dry flat. Do not iron.
- RorschachMasks is a registered trademark. Do not buy from other sellers, as these are not their images or product.
Details: HERE IT IS ... the best animated Rorschach inkblot mask you will find. Thousands sold in over 55 countries, 1.5+ million video views on Youtube and now in our 7th year offering these! No special effects needed. Your warm breath fades the ink to transparent; cool air darkens it producing a moving effect. What you see is what you'll get! A little practice goes a long way. The patterns are made using nontoxic, 100% safe thermochromic ink that reacts to your breath. So you control the effect! It simulates the animation of the inkblot amazingly as seen on countless videos online. The mask is a High Performance (non-allergenic spandex blend) custom hood seamed to fit most heads. For measurement's sake, around the forehead is 22" to 24" inches. But using a 4-way stretch fabric (nylon/spandex blend) allows the mask to fit most people comfortably. Visibility is good in well-lit areas and breathability is ideal. For maximum visibility, stretch the mask vertically and horizontally over the eye area to open the weave.


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Oh my gosh I cannot believe it has been 2yrs since I last post to my blog! I think or now realize that life has truly gotten in the way! I have not even been active on my Crafty Queen facebook page. I guess with the new year fastly approaching I need to make some commitments to staying in touch.
Friday, December 4, 2015
Friday, November 8, 2013
Hello my crafty friends.....goodness I've not written a post since April...I guess it just seems life gets in the way. I have been posting on my facebook page though. I also started a instagram page. Not sure how I like that!
With the holiday's around the corner, I am sure everyone is wondering what will I make this year. I am hoping to stay regular on updating my blog. I have some really fun items that I will be making this holiday season and cannot wait to share them with you all.
Halloween turned out to be a busy one for this Crafty Queen....I made some pumpkins (faux) for our grandbabies, once everyone realized they were not really the craze kicked off. I purchased one of the faux pumpkins a couple of years ago at Michaels (sticker shock!!!) and made a welcome sign in vinyl to place on this said pumpkin. Well, this year after making the new ones (with ideas from my other crafty friends! You know, "Imitation is the greatest form of flattery!" (Some people on the web who like to sling copy write infringement need to remember this!...) Anywho, without further ado....some of the pumpkins that were created by MIO~~~
These beauties were created using my cameo, the font on all of them is one called 2 peas Mr.Giggles, this is a font is a purchased font, it is created by 2 peas. It is just such a fun font to use....for the polka dots I used my stampin up 1in punch, on some of them I also used the 3/4in punch. The bling stars on the boys pumpkins is also a purchased file, created by some good friends of mine, head over to www.customrhinestonedesign.com the file you are looking for is: blingstars CS esp svg ( I just love those stars!!!) I could not believe how popular the black faux pumpkins would be! They were a HUGE hit!!! I am officially the Crazy Pumpkin lady!!! Enjoy the rest of the photos & until next time...Do something Creative everyday....love love love Crafty Queen
This was the little beauty I purchased a couple of years ago at Michaels (sticker shock) and I decided to give it a little love this season! It of course is out on my porch for the pending Thanksgiving Holiday (almost the lost Holiday..poor Thanksgiving)...and then the next one is a gift I made for our daughter & son in law of both of their birthday's and now they have another pumpkin to display with pride. (the last pumpkin above with Don & Tammy was used as a wedding gift! They had a Skelly themed wedding..hence the Mr& Mrs on the backside with there wedding date!)
Good night my crafty PEEPS =)
Tuesday, April 16, 2013
Hi Crafty friends
I was hired by a friend to create the decor and pretty up the prizes for her baby boy Karsyn's shower.
She found quite a few of these ideas on Pinterest....please enjoy these goodies....
Piggy bank...can you spare some change
It's a "HE" hershey bars
I love this idea of the alphabet and highlighting the letter of baby's name
Gifts displayed as decor...the candles below are in the wrapping
I just love how this candles turned out!


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The "Rheingold" had a rich tradition and ran starting in May 1965 as a Trans-Europe-Express (TEE) in the two-color TEE scheme of a crimson red belt line and an ivory window band. From May 23, 1982 on, its route was limited to Amsterdam – Basle SBB. A year later there were only two TEE trains left: the "Mediolanum" (Munich – Milan) made up of FS cars and the TEE 7/6 "Rheingold" that was viewed more as a tourist attraction. Starting with the summer schedule of 1983 all of the Rheingold cars were run with overhauled interiors and were provided with an orange decorative stripe below the windows for purposes of identification. New among the cars was the club car (type WGm 804) that presented the lettering "Rheingold-Club" on the sides. Three of these "new" club cars were made from former open seating cars and they now had a small galley and fifteen rather ordinary tables with 34 swiveling armchairs. In addition, three regular dining cars were available for the route Amsterdam – Basle. There were also fifteen compartment cars and six open seating cars. In the club cars the DB provided beer on tap and snacks among other things from the small bistro for the comfort of the passengers. Hired musical and folklore groups provided entertainment part of the time. In the summer of 1986, there was even a whirlpool tub in addition to an artificial palm for a couple of days to offer the opportunity for a soak.
Indeed the "Rheingold" was now limited primarily to the route Amsterdam – Basle, yet it still occasionally ran through cars to Chiasso, Brig, and in the winter to Chur. In addition, a branch train (TEE 17/16) to Munich with train separation/joining in Mannheim (later Mainz) rounded out the new concept. In the last two years of its existence (1986/87 as TEE 15/14), the through cars to/from Brig and Chiasso also disappeared. There were still through cars between Amsterdam and Chur only in the winter season. Up until May 30, 1987, the legendary "Rheingold" still snaked day after day through the maze of track in the Ruhr area, past the Cologne cathedral and the Lorelei cliffs, and crossed the Upper Rhine plains between the Black Forest and the Vosges. Yet with the start of the summer schedule on May 31, 1987 and the introduction of the EuroCity trains, the last TEE still running in Germany disappeared completely from the rails of the German Federal Railroad.
Motive power for the "Rheingold" until its end was the class 103.1 electric locomotives as the classic flagship locomotive for TEE and IC trains. Regular production of them started in 1969, and by 1974, there were 145 of these powerful six-axle units with road numbers 103 101-245 on the DB roster. They were designed from the start for a speed of up to 265 km/h / 166 mph, but they were only allowed to run at a maximum speed of 200 km/h / 125 mph. The 103 units with their elegant streamlined shape and the Siemens rubber ring spring cardan shaft propulsion was the most powerful German electric locomotive and had an hourly rating of 7,780 kilowatts / 10,581 horsepower.

domain: hobby


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Spring Wedding Dresses
- Della: The Queen
- Button Butterfly Sleeves Graceful V-Neckline Side Dress
- casual scoop-neck Half-sleeve Dress With Deep-V Back And Appliques
- Illusion-Sleeve Ribbon Long Sheath Lace Dress
- Bateau Cap-sleeve Sheath Tulle Wedding Dress With Appliques
- A-Line Short Sleeveless Sleeve Chiffon Lace Satin Dress
- High-low Bateau Sleeveless Illusion Back Satin Dress With Bow
- Lace Deep V Back Fishtail High-Neckline Wedding Gown
- Ball Gown Short Long Sleeve Bell Bat Appliques Flower Button Tulle Lace Dress
- A-line Lace V-neck Knee-length 3/4 Length Sleeve Ruched Wedding Dress
- Mermaid Lace Off-the-shoulder Floor-length Short Sleeve Wedding Dress with Pleats
- Off-the-shoulder Short Sleeve Natural Bandage Pleats Ruffles Wedding Dress
- A-line Satin Lace Scoop Floor-length Sweep/Brush Train Short Sleeve Pleats Wedding Dress
- Off-the-shoulder Half Sleeve Natural Pleats Ruffles Wedding Dress
- A-line Chiffon Off-the-shoulder Chapel Train Sleeveless Lace Pleats Ruched Wedding Dress
- A-line Chiffon Sweetheart Court Train Sleeveless Wedding Dress with Beading and Pleats
- A-line Tulle Off-the-shoulder Spaghetti Floor-length Court Train Long Sleeve Wedding Dress with Appliques and Beading
- V-neck Short Sleeve Empire Beading Sash Ribbon Wedding Dress
- V-neck Short Sleeve Empire Bow Sash Ribbon Wedding Dress
- V-neck Short Sleeve Empire Pleats Sash Ribbon Wedding Dress
- Off-the-shoulder Short Sleeve Empire Beading Pleats Wedding Dress
- Wedding Lace Bow Strapless Country Gown
- Sleeveless Rhinestone Chiffon Ruched Floor-Length A-Line Illusion Dress
- Backless Appliqued Sleeveless Strapless Organza Gown
- Tulle Lace Appliqued 3-4-Long-Sleeve Elegant Gown
- refined Lace Long Sleeve Mermaid Wedding Dress With Illusion And Tulle Sweep Train
- casual V-neck Sleeveless draped Wedding Dress With Sweep Train
- A-Line Bateau Neck Satin Long-Sleeve Gown
- Scoop-neck Sleeveless Tulle Ball Gown Dress With Appliques And Low-V Back
- A-line Sweetheart Tulle Wedding Dress With Flowers And Appliques
- A-line Half Sleeve Satin Wedding Dress With Jeweled waist
- Court-Train Bridal Off-The-Shoulder A-Line Lace Dress
- Romantic Garden Style Tulle Off-the-shoulder Cap Short Sleeve Wedding Dress with Flowers
- Classic Simple Long Sleeves Lace Beach Knee-Length Wedding Dress with Beadings
- Stunning V-neck Sleeveless Brush Train Wedding Dress with Appliques
- Elegant Bohemian Chiffon Low-V Back Garden Wedding Dress with Lace Appliques
- Elegant Garden Style Chiffon High-neck Sleeveless Floor-length Wedding Dress with Lace
- Enchanting Sexy Plus Size Mermaid Deep-V Back Jersey Dress with Pleats
- Romantic Garden A-Line Lace Sleeveless Scoop-Neck Wedding Dress With Appliques
- High Neck Illusion Ball Gown Wedding Dress With Appliques And Beadings
- Appliqued Backless Sweetheart Mermaid Wedding Dress With Straps And Lace
- Glamorous Bohemian Tulle Lace Two Piece Court Train Wedding Dress with Appiliques
- Adorable Country Style Organza Scoop-neck Ruffled Cap-sleeve Ball Gown Wedding Dress with Lace
- A-line Simple V-neck Wedding Dress with Lace And Long Sleeves
- Ethereal Bohemian Two Piece Long Sleeves Floor Length Wedding Dress with Pleats
- Jewel-Neck Tulle Long Sleeve Floor-Length Vintage Corset Back Garden Wedding Dress
- Elegant Country Style Plus Size Lace V-neck A-line Illusion 3/4 Sleeve Court-train Wedding Dress
- Dreaming Long Sleeves Lace Bohemian Deep-V Back Wedding Dress
Spring Wedding Dresses
CUSTOMER REVIEWS (876)Spring Wedding Dresses
By Stephanie Fitzgerald
This dress is even more beautiful than the photos! I love everything about it. The lace material is very elegant. Shipped on time and absolutely amazing workmanship. What a stunning dress!
By Shery airly
My daughter is thrilled with this wonderful dress! And the quality is excellent!!
By Christ joanna
This is made well and the material is very light!
By Jackie Kahn
The material is soft and good quality. The color matches my color perfectly! What a great seller! Fast shipping and good communication. Thanks!
It came right away and it's gorgeous!! Love it! It completes my gorgeous wedding dress. I couldn't be happier. The dress arrived promptly and was exactly what I wanted! I can't wait to show it off at my wedding!!!
I was extremely happy with this purchase. The dress was beautiful, well-made, it fit perfectly, and I received a lot of compliments on it. It's great for the bride who wants to personalize their look a bit. It did not ship on time, but they were quick to respond and get it shipped out once I contacted them. I was really impressed with the communication I had with Dressafford.
By misty sauceda
I love my gown. I got it in white and it came out just like I thought. It would my breast are big but the dress fits perfectly. Shipping was fast, also all my questions was answered with a quick reply with great customer service even before I placed my order.
Wonderful dress! So comfortable and elegant. Can't wait to wear it!
By Ashley Maranino
Unfortunately mine did not fit as expected but I give 5 stars because I received the dress quickly and well made and was given a refund when it didn't fit. For those reasons - customer service is very good.
By Cheyenne Rickley
Beautiful gown, very well made. The material it is very soft and not transparent at all. Cannot wait to photograph this item!
Love, love, love, my wedding dress!!!!! Can't wait to wear my gown.Lucy did such an amazing job thank you so very much. She was so very patient and answer all of questions and concerns that I had. She makes such beautiful gowns my friends couldn't believe that it was made from a site shop. Thank you again Laurie!
By WOMAN ANAN
I absolutely love this dress! So beautiful and fEmmynine! Soft and fit fabulously!
Dressafford is a wonderful shop and you can absolutely see the quality workmanship, attention to details, and the love the shop owner puts into every garment. Highly recommended.
I ordered this and gave Junebridal my measurements and it came perfect. It fits me perfectly and looks like the one in the photo. Thank you again Junebridal, I am so impressed.
By Alison Stinson
I ordered this gown literally a month before my wedding. I paid for rush service, and received the dress earlier than promised. The gown fit perfectly, and I could not be happier with the result. Really love the appliques. Thank you guys so much!
- View more

domain: design


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When: Mon., Feb. 11, 12 p.m. 2013
You've had a month to recover from whatever New Year's shenanigans you partook in. Know what that means? Time for some more New Year's shenanigans. The Chinese kind. The Chinese Fine Arts Society is hosting a Chinese New Year celebration in Daley Plaza to ring in the Year of the Snake. Local Chinese folk artists perform music and dance, including the Lion Dance, because, maybe there's not a snake dance?


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Last year G and I found our chats over dinner, dishes, and stuck-in-traffic moments were often wandering to the same place. We kept returning to a soft ache – for idleness, for quiet, for space. He talked about working towards selling everything and moving to Nowhere. How it would feel to live simply and lightly surrounded by bush, by sea, by sky. We talked about trips, remote spots to stay, and long hikes with soaring scenery. I imagined wilderness, silence, just-us-ness. Deep lungfuls of air that smelled of pine needles and salt. But in all the well-worn conversational tracks, we always seemed to imagine that true restoration, for us, was to be found at a place. A remote, wild, uncomplicated place – miles from traffic and people and cell-phone coverage. We envisaged a beautiful cabin. Fantasised about star-lit nights and slow unscheduled days.
I still badly want to make this place.
But we also love our lives here in the city. And our weekends, while often chore-laden, are rich with friends and fun. So something nagged at us – how often would we actually make it this place? Once a month? Once every two? And the cost. With the necessity of paying guests would our quiet place simply become another chore to be attended to? For us at least, ceasing to be what we had intended?
And I was curious. Did others feel this need for sanctuary? How did they create moments that sustained them? I interviewed friends and colleauges and acquaintances – tell me about your day to day life, tell me about your last holiday, tell me about the stuff that makes you feel drained. And then: tell me about the things in your life that help you feel vibrant, whole, resilient.
We talked about exercise – not-negotiable daily yoga practice, paddle-boarding sessions scheduled between meetings, 5am walks. Prioritising time to be by ourselves versus feeling amazing because we have spent time with our friends. Holidays were divisive: Wholly necessary, or a logistical and financial luxury? Restorative long beyond the actual time away (anticipating, reliving)? Or a fleeting, feel-good blip – the benefit of which is seriously undone by the schedule stress prior and post. We talked about the nourishing practice of finding pleasure – flowers on the counter, a scented candle burning, a bed with fine sheets, a delicious treat. A moment each evening sitting on the deck looking out to sea. We talked about how sometimes, sometimes, all that we can think of to prop ourselves back up again after a total shit-storm of a day is an evening of indescribably bad TV. Several glasses of wine. A mountain of whatever chocolatey junk can be ferreted out from the depths of the kitchen cupboards. And in that moment, that’s exactly what we need. But how, at other times, being disciplined, and intentional, and self-reflective is how we create nourishment – how we build pockets of sanctuary into our lives, and fortify ourselves with resilience.
And I realised, high on connectedness, that restoration is a Thing – a big, complex, multi-faceted Thing. What renews me, might make you feel lonely. That weekend road trip with no fixed destination, which makes you feel bulletproof again, may make me so anxious I bury my fingernails into my flesh and ask on repeat when we can stop for a cup of tea and a lie down. What gives us sanctuary today may be the exact opposite of what we need tomorrow. How being delighted by the one or two or three times a year we get to leave home and take a holiday is not enough. That we can feel restored everyday – by a place, by a person, by a thing, by a moment.
Tiny Sanctuaries. In all their forms.