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Is CBD good for rest? Many people are still not mindful that this usual all-natural herb is a potent all-natural treatment for sleeping disorders. There are many benefits of CBD for rest. Yet prior to you take CBD for sleep, be sure to do your research first.
Some recent researches indicate that CBD could help you rest better, yet with mixed outcomes. As well as although there have been some encouraging study on the ability of CBD to assist you fall asleep, scientists claim that there are currently no scientific trials that in fact show CBD can do that in all. Actually, none of the approved CBD products have actually ever before been authorized by the FDA to deal with resting troubles. Because the FDA has never ever approved CBD for a medical use, it is not shocking that there is a lot of conflicting details on this subject.
2 of the most common uses of CBD for rest include treating anxiousness and improving mood or anxiousness signs and symptoms. Both these areas of therapy are popular with patients. For instance, research studies carried out by the University of Geneva in Switzerland record that patients who took an entire CBD capsule prior to going to sleep experienced a decrease in their degrees of stress and anxiety after the treatment was given. In some cases, the complete amount of CBD taken decreased the patient’s requirement to have any type of type of prescription rest aid.
Nevertheless, the most significant indicator that CBD works for dealing with rest problems might be the reasonably reduced dose commonly suggested by medical professionals. In most cases, CBD is available in oil kind, which suggests that the individual will certainly need to use a vaporizer or oil burner in order to inhale the oil. This is not a trouble for lots of people, as inhalation of CBD is reported by many individuals as fitting and also satisfying. But also for those who can not find an oil burner or various other ways of inhalation, CBD can also be taken sublingually, which suggests that a percentage of the drug is massaged on the top of the tongue before intake. Oral intake of CBD has not been documented to create any type of negative side effects for lots of people.
Along with dealing with rest conditions like insomnia, CBD is believed to be effective versus some even more significant disorders. The American Medical Organization has approved some of the more popular CBD items for dealing with youngsters with epilepsy, persistent discomfort, and nausea, among other points. While this is not a full listing of disorders that CBD items might be utilized for, it does display a checklist that ranges from much less severe conditions to a lot more severe ones. On top of that, lots of CBD sellers keep in mind that CBD is simply one of the many vital oils utilized in aromatherapy. Cbd Topicals Reddit
In a comparable fashion, CBD is utilized to deal with some forms of depression as well as anxiousness. These problems are typically treated with psychotherapy and prescription medications, as well as the relationship in between CBD and also sleep problems is becoming extra evident as even more interest is paid to how our rest patterns influence our moods. Some researches have also revealed that CBD is useful in the treatment of persistent clinical depression, a condition that can last for months on end. When seeking therapies for persistent sleeping disorders, bear in mind that some of the most promising supplements integrate CBD with a number of various other all-natural active ingredients that are recognized for their performance in boosting sleep as well as state of mind.
If you wish to attempt an item that combines CBD with natural, reliable active ingredients, there are a couple of internet as well as gummies on the market that have actually proven to be useful in the therapy of sleeplessness. Simply searching “CBD for sleep problems” will certainly bring up numerous products that are suggested for use by victims. The majority of these website supply samples to check for yourself, and also they are reasonably priced. You do not have to acquire the whole web and gummy plan to see if it assists your condition, simply buy a number of these at different times of the week.
Although lots of people assert success with CBD for sleep as well as state of mind, there’s still no definitive scientific evidence that the remove does work. However, many individuals who have tried it do report positive outcomes, even in the short-term. If you do choose to try a CBD supplement or 2, be sure to speak to your healthcare provider beforehand, especially if you’re taking any medicines or supplements. Your doctor can recommend a secure and also efficient dosage for you based upon your case history and existing symptoms. Cbd Topicals Reddit

domain: medical


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mouse over or click image(s) to enlarge
Game Of Thrones Khal Drogo Vinyl Figure
Normally ships in 1-3 day(s)
- Inspired by the HBO series Game of Thrones
- 3.75" Dothraki leader Khal Drogo vinyl Pop! figure
- Makes a great collectors item for Game of Thrones fans!
- Brand new in windown box packaging
- Officially licensed

domain: hobby


HARPERS FERRY – John Brown’s raid on Harpers Ferry will mark its 159th anniversary next week and while for some, it’s a story relegated to the history books, others say what unfolded here continues to stir passions.
The raid and Brown’s subsequent capture and execution in Charles Town have inspired a new musical tribute called “Glory, Glory” by the R.J. Phillips Band.
Joe DeFilippo, who wrote the tune, called the anthem long overdue. “I’ve visited Harpers Ferry dozens of times and continue to sense the sacred nature of the historical site,” he said. “When members of the Niagara Movement, which included W.E.B. DuBois, visited Harpers Ferry in 1906, they described the site as ‘holy ground.’ I can understand why.”
He notes that during the Civil War, “John Brown’s Body” became a popular anthem sung by Union troops.
DeFilippo added that it was the hope of the band to bring a historical awareness to the public through music. “The combination of an inspiring story with a moving melody has a way of reaching people,” he said. “Who knows, our songs might encourage the listener to give thought to the events and people that have shaped our nation.”
Alice Keesey Mecoy, a descendant of Brown, said that “Glory, Glory” “expresses the importance of John Brown’s fight against slavery and the value of his death to that cause. The tribute to my great-great-great grandfather is a favorite of mine.”
Although Brown had his critics, DeFilippo points out that he also had ardent supporters.
Abolitionist Frederick Douglass, who escaped from slavery in 1838 and opted not to join Brown at Harpers Ferry, famously said: “His zeal in the cause of my race was far greater than mine … I could live for the slave, but he could die for him.”
“I guess that quote by Douglass pretty much says it all,” DeFilippo said. “Over 150 years later, John Brown’s soul is still marching on.”
The modern song dedicated to Brown is not the first tune with a historical theme written and recorded by the R.J. Phillips Band.
The band also has created songs paying homage to Abe and Mary Lincoln, Olympic great Jesse Owens, the Native American occupation of Alcatraz and other figures in history.


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For now, Florida has been granted a preliminary injunction that could render restrictions on cruising to and from the state imposed by the CDC as optional guidance starting next month.
"This order finds that Florida is highly likely to prevail on the merits of the claim that CDC’s conditional sailing order and the implementing orders exceed the authority delegated to CDC," the conclusion of the 124-page ruling issued by Judge Steven Merryday on Friday.
Republican Gov. Ron DeSantis called the ruling a win for Florida in a statement Friday.
"Today, we are securing this victory for Florida families, for the cruise industry, and for every state that wants to preserve its rights in the face of unprecedented federal overreach," DeSantis said.
What happens if the COVID gets on board? US cruises are restarting after a COVID-induced hiatus.
Cruises are coming back:Here are the ships that have received CDC approval to sail soon
The state of Florida filed a complaint against Xavier Becerra, secretary of Health and Human Services, in U.S. District Court in the Middle District of Florida's Tampa Division, alleging that the CDC exceeded its authority in issuing its "Framework for Conditional Sailing Order," published in October.
Florida has also instituted a ban on vaccine passports, preventing businesses, including cruise lines, from requiring patrons to show proof of vaccination prior to entry. The ban goes into effect on July 1, though it is also outlined in an executive order from DeSantis.
That ban is in conflict with the CDC's cruise regulations, which require ships to carry a certain threshold of vaccinated passengers to cruise in U.S. waters without conducting test cruises first.
As a result of the ruling, it is possible that the CDC's "Conditional Sailing Order" will become only a recommendation as opposed to rule in Florida on July 18. However, through July 2, the CDC has the opportunity to propose a narrower injunction until July 2.
USA TODAY has reached out to the CDC.
"(The industry is) free to cruise unless the CDC comes up with a more narrow definition," Jim Walker, maritime and cruise attorney, told USA TODAY Friday.
The health agency and the state of Florida have been sent back to mediation.
Walker said that he believes this could add to the "chaos and confusion of cruising during an ongoing pandemic." He also said he believes it will ensure additional COVID-19 outbreaks.
"Cruise ships operating without strict COVID protocols in the 'anything goes' world of Gov. DeSantis will crash into a stark reality when cruise ports enforce their own protocols," Walker said.

domain: news


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Tomas Andres Cabrera Wiki – Tomas Andres Cabrera Biography
A Florida school bus driver is accused of sexually assaulting one of his passengers after surveillance video showed him touching and kissing one of her breasts through her clothing, according to the Collier County Sheriff’s Office. The driver was identified as Tomas Andres Cabrera , 57, authorities said in an April 1 news release.
“The victim told a school district employee on Thursday (March 30) that the bus driver, Cabrera, touched and kissed her left breast on his clothing,” the sheriff’s office said.
Tomas Andres Age
The age of Tomas Cabrera is 57 years.
Tomas Andres Cabrera accused of sexual abusing a minor
“Detectives, in coordination with our Office of Youth Relations and the School District, obtained a copy of the surveillance footage of the school bus. Detectives said the footage clearly and intentionally shows Cabrera touching and kissing the victim’s left breast on top of his clothing.”
Details of the victim’s age and his school were not released. Cabrera was arrested March 31 at his home in Naples and is charged with lewd and lascivious sexual abuse of a victim under the age of 12 by someone 18 or older, jail records show.
The investigation is ongoing, authorities said. Collier County Public Schools, based in Naples, has just under 50,000 students enrolled in 63 schools, according to Collierschools.com. The researchers identified the schools affiliated with the Cabrera bus route.Read More…..

domain: law


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Stoughton marks 11th anniversary of terrorist attacks
Greg Bourget remembers stepping into hell. “All you saw was rock, steel and glass,” he said. “Paper was continually falling ... Everything was just ground up to nothing.”
That’s how Bourget, who was part of the Norfolk County critical incident stress management team, recalls arriving at ground zero in New York City after the terrorist attacks on Sept. 11, 2001.
Bourget, a Stoughton firefighter, was among the public safety officers and others across the region who attended ceremonies on Tuesday to mark the 11th anniversary of the attacks.
Flags snapped in the breeze. Trumpeters played taps. Bagpipes issued their mournful sounds. Firefighters rang bells in tribute to those who were lost.
Bourget and several other Stoughton firefighters and police officers spent six days in New York assisting those who responded to the attack’s aftermath. He remembered talking to a firefighter who arrived after the World Trade Center towers fell.
“There were 10- to 12-story buildings burning all around him,” Bourget said. “Where do you start?”
He said everybody, not just public safety crews, did what they could, including ironworkers who helped clear debris and those who brought food to weary rescuers.
“There were a lot of heroes there not wearing a uniform,” he said.
Ceremonies and patriotic displays were also held locally Tuesday in Quincy, Braintree, Weymouth and Hull.


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María Martínez Iturriaga
María Martínez Iturriaga is the senior vice president for the Berklee Global division, including oversight of all Global Initiatives programs and partnerships, the Abu Dhabi Center, and new projects with strategic relevance for advancing Berklee’s global engagement and presence. She is responsible for expanding Berklee’s global impact through the creation of an interdisciplinary ecosystem of learning environments and partnerships that foster and inspire new artistic expressions, exchange, and innovative collaborations.
Joining Berklee in 2008, Martínez Iturriaga was at the forefront of establishing the college’s first international campus in Valencia, Spain, where she served as executive director from 2016 to 2023. In her 15 years of dedicated service to Berklee Valencia, Martínez Iturriaga played a leading role in defining academic, enrollment, and institutional strategies for Berklee abroad. She developed and implemented the enrollment strategy for the first graduate programs offered at Berklee, created the International Career Center, and launched academic programs such as First Year Abroad, among other initiatives. In 2020, she led the negotiations that resulted in an agreement for Berklee to expand its footprint at Valencia’s iconic City of Arts and Sciences and remain for an additional 40 years.
Under Martínez Iturriaga’s leadership, the Valencia campus served more than 4,000 students from 85 countries, and fostered an international team of over 100 staff and faculty from more than 20 countries. During this time, the campus pioneered new programs and initiatives such as the Global Career Summit and the Boston Conservatory Opera Intensive, and developed educational and artistic collaborations with local and international institutions such as the United Nations, the Association of European Conservatories, MIDEM, the Palau de les Arts, the Fundación Paco de Lucía, and the Escuela Superior Reina Sofía.
A staunch supporter of equity in the arts, Martínez Iturriaga also supported the launch of initiatives to empower women in the music industry, including the Women and Conducting Symposium, Berklee Valencia's chapter of Women in Music, the Women's Empower Symposium, and She Knows Tech.
Martínez Iturriaga holds a master’s degree in performing arts administration from New York University, a bachelor's degree in business administration from the Universidad Autónoma de Madrid, and a bachelor's degree in piano performance from the Real Conservatorio Superior de Música in Madrid.
Prior to Berklee, she worked with AEA Consulting in New York, one of the world's leading arts, culture, and entertainment consulting firms, where she assisted clients such as the New York City Opera, Fundación Televisa, Museo del Barrio, the Victoria and Albert Museum, and the Hispanic Society of the Americas. She is a trustee at Fundación Cañada Blanch and a member of the Comité Protector de la Música del Reciclaje de Ecoembes, chaired by Queen Sofía of Spain. She has penned articles for Harvard Business Review, Conectando Audiencias, and Mujer Emprendedora, and composed the music for the short film Thimea.

domain: artistic


Will it Blow?
Phil Kinnane February 15, 2012
Join our free webinar tomorrow, February 16, on Joule Heating. Hosted together with IEEE Spectrum, COMSOL Support Engineer, Linus Andersson will ask the question: “Will it Blow?”
Modeling Joule Heating
Actually, he will give you a great run-through of Joule Heating and how it is best modeled using COMSOL Multiphysics. It will, of course, not only cover straight resistive heating, but will also touch on RF and Microwave Heating as well as the coupled effects that temperature has on resistivity etc.
The fuse you see in the picture will be modeled, and the question will be answered if you join us for our Joule Heating webinar.


"Graduation refers to an Act of 1854 that reduced the price of public lands that had been
on the market for more than 10 years. Sales were to benefit bona fide
settlers and adjoining farm owners. There were no specific residence
and improvement requirements but [there was] a 320 acre limitation.
The law was repealed in 1862. Most lands were in Alabama, Arkansas
and Missouri. Nearly 26 million acres sold under the Act."


text:
Not Yet Rated|
1 hr. 40 min.
A bartender (Jeremy Jones) tries to reconnect with the father (John Schneider) who abandoned him as a child.
John Schneider, Bill Cobbs, Nicole Gale Anderson, Jenna von Oy, Jeremy Jones,
Release Date: January 1st, 2012|1 hr. 40 min.

domain: library


text:
Controlled drug delivery systems for cancer based on mesoporous silica nanoparticles
Received 19 December 2018
Accepted for publication 11 March 2019
Published 8 May 2019 Volume 2019:14 Pages 3389—3401
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Anderson Oliveira Lobo
Nerea Iturrioz-Rodríguez,1 Miguel A Correa-Duarte,2,3 Mónica L Fanarraga1
1Nanomedicine Group, University of Cantabria – IDIVAL, Santander, 39011, Spain; 2Department of Physical Chemistry, Center for Biomedical Research (CINBIO), Southern Galicia Institute of Health Research (IISGS), Vigo 36310, Spain; 3Biomedical Research Networking Center for Mental Health (CIBERSAM), Universidade de Vigo, Vigo 36310, Spain
Abstract: The implementation of nanotechnology in medicine has opened new research horizons particularly in the field of therapeutic delivery. Mesoporous silica particles have emerged as biocompatible drug delivery systems with an enormous potential in the treatment of cancer among many other pathologies. In this review, we focus on the unique properties of these particles as chemotherapy delivery carriers. Here, we summarize the general characteristics of these nanomaterials – including their physicochemical properties and customizable surfaces – different stimuli that can be used to trigger targeted drug release, biocompatibility and finally, the drawbacks of these types of nanomaterials, highlighting some of the most important features of mesoporous silica nanoparticles in drug delivery.
Keywords: nanocarrier, drug release, targeted drug delivery, biocompatibility, biodegradability, tumor
Chemotherapy, tog ether with surgery, are the most used cancer treatments in oncology. Unfortunately, chemotherapeutic agents are applied systemically destroying both tumor and healthy cells and resulting in many of undesirable side effects.1 Encapsulated drug delivery systems offer the possibility to target therapies locally at adequate concentrations, maximizing the effect against cancer cells while reducing the side effects and cytotoxicity in healthy cells.2 In this sense, nanotechnology can help with the design of target-specific and controlled delivery systems, capable of transporting enough therapies to specific cells, releasing the drug in a controlled manner.2
Different types of nanomaterials have been used as targeted carriers. Among others, the most employed are liposomes,3,4 polymeric micelles,5,6 carbon nanotubes,7 dendrimers,8–10 inorganic particles11 and silica-based materials12,13 (Figure 1). Recently, mesoporous silica particles (MSPs) have attracted much attention due to their singular properties.14 Here we discuss some of their characteristics and advantages in cancer drug delivery.15
Figure 1 Schematic representation of different delivery systems. From left to right; liposomes, micelles, carbon nanotubes, dendrimer and gold (yellow) and iron (brown) nanoparticles.
Physicochemical properties of MSPs
MSPs have a well-defined internal mesopore structure (from 2 to 10 nm of diameter) with a large pore volume (0.6−1 cm3/g) and a high surface area (700−1,000 m2/g). Their size, nano- (50 nm) to submicron-scale (500 nm),16 as well as their shape17 and surface18 can be custom-designed offering many different possibilities for the loading of anticancer drugs such as docetaxel,19 paclitaxel20 or doxorubicin,21 among many others. Moreover, the cytotoxicity of these particles and cellular uptake have been demonstrated to be dependent on nanoparticle size and surface charge. Indeed, 15 nm diameter particles have been reported to trigger more cytotoxicity than 100 nm diameter particles in endothelial cells.22 Lu and collaborators showed that 50 nm diameter particles are the optimal for cellular uptake.23 When considering the particle surface charge, cationic silica particles appear to be more cytotoxic and have a faster cellular uptake than anionic or neutral silica particles.24,25 Davila-Ibáñez and co-workers used magnetic silica nanoparticles with DNA attached to the silica network to show how charges at the surface of the nanoparticles is a key issue to guarantee the cellular uptake.26,27 On the other hand, particles with a neutral charge do not appear to internalize the cell membrane of Caco-2 cells.
Targeting the cell/tissue of interest
One of the most important goals to achieve in drug delivery is the possibility of targeting nanoparticles to a specific cell or tissue. In this regard, most nanomaterials including MSPs, have been reported to passively target solid tumors. Typically, when a tumor reaches a certain size, the normal vasculature present in the tumoral organ cannot irrigate all the cellular mass. This effect generates intra-tumoral hypoxia triggering the segregation of growth factors that activate the rapid sprouting of new blood vessels from the surrounding capillaries.28 This process known as angiogenesis generates irregular blood vessels displaying a discontinuous epithelium with an absent basal membrane.29 When blood components reach these abnormal and discontinuous vascular networks, the fenestrations between the endothelial cells offer little resistance to the extravasation of nanomaterials inside of the tumor.30 Particles/molecules smaller than 4 nm diffuse through the capillary endothelium back to the blood circulation and are reabsorbed,31 but macromolecules and nanomaterials do not naturally return to the blood vessels, accumulating in the perivascular tumoral space. In the nanomedicine field, this phenomenon is known as the Enhanced Permeability and Retention effect or “EPR” effect (Figure 2). The study carried out by Lee and co-workers, showed how MSPs decorated with multiple magnetite nanocrystals loaded with Doxorubicin (DOX), induced efficient cell death in a melanoma model, confirming in vivo passive targeting and accumulation of the nanoparticles in the tumor site.32 Huan and colleagues used MSPs functionalized with polyethyleneimine/polyethylene glycol (PEI/PEG) to carry doxorubicin together with P-glycoprotein siRNA. Their study demonstrated that these particles were effectively biodistributed, achieving an 8% of the enhanced permeability and retention effect at the tumor site in vivo.33 But there are many more examples in the literature.
Figure 2 Image representing the blood transport mechanism of nanomaterials or molecules from normal tissue (left) and the enhanced permeability and retention effect in a tumor.
MSPs can also be functionalized to actively target tumors. One of the strategies used to reach this goal consists in the attachment of different ligand molecules – such as peptides, antibodies,34 aptamers,35 growth factors,36 vitamins, etc. – on their surface, so the particles interact with receptors on the cellular surface (Figure 3).37 This way, the entry mechanism of the nanodevice will be via receptor-mediated endocytosis, and the particle will be captured inside the endosomal membranes.37 In the study carried out by Kayuan and colleagues, HB5 aptamer-functionalized mesoporous silica-carbon-based DOX-loaded systems (MSCN-PEG-HB5/DOX) were used in vitro for chemo-photothermal combined therapy in Human Epithelial growth factor Receptor 2 (HER2)-positive breast cancer cells. This study demonstrated how HER2-positive breast cancer cells uptake these particles with more avidity than normal breast epithelial cells (MCF-10A). Additionally, cytotoxicity experiments demonstrated that combined therapy induces highest cell killing effect compared to chemotherapy and photothermal therapy by itself.38 Jianbin and colleagues showed how MSPs of 40 nm size, loaded with DOX and functionalized with selective αv-β3 integrin ligands on their surface displayed an enhanced targeting effect through the blood–brain barrier, penetrating glioblastoma cells. In summary, these targeted particles rapidly invaded cancer cells, delivering the drug intracellularly and improving the anticancer activity of the free drug. MSPs achieve satisfactory anti-glioblastoma efficacy avoiding toxic side effects in the healthy brain tissue thus, demonstrating active cell targeting.39
Figure 3 Schematic description of active targeting possibilities on mesoporous silica particles (left). Dual targeting example (right).
Controlling drug release: gatekeepers
Another challenge in the design of nanotransporters is delivering the drug at the precise moment when the carrier reaches the tumor, or alternatively, when a signal is provided. MSPs are useful carrier systems due to their high surface and tunable porous structure. Drugs can be loaded inside their mesopores through simple diffusion mechanism. But, one of the main advantages of MSPs is the possibility to design “zero release” nanosystems by blocking the MSP pores using gatekeepers.13,40
Once in the tumor, different internal or external stimuli can be employed to activate drug delivery. Some of the intra-tumoral stimuli used are the local pH conditions, the enzymes in the peritumoral tissue or the redox potential. In addition, external stimuli such as magnetic fields or light can also be applied to activate “on demand” drug release (Table 1, Figure 4).
Table 1 Different gatekeepers that can be used to maintain the “zero release” of the drug and to trigger drug release
Figure 4 Examples of different gatekeepers that can be used to maintain the “zero release” of the drug inside mesoporous silica particles and to trigger on demand the release.
Internal stimuli triggering drug delivery
The characteristics of the tumoral environment can help in the design of nanocarriers sensitive to internal or endogenous stimuli to ensure a controlled localized drug release.
- pH-sensitive systems
One general feature of solid tumors is the presence of acidity in the tumor environment due to the “Warburg effect”. Healthy cells use the mitochondrial oxidative phosphorylation to produce energy. However, most cancer cells activate the glycolytic route.41,42 This process, also known as anaerobic glycolysis, is less efficient in terms of energy (adenosine triphosphate) production and increases the generation of additional metabolites – mostly lactic acid – generating local tumoral acidosis which can be beneficial for tumor proliferating cells.41,42
An effective strategy to control drug release is blocking the MSP pores with noncovalently bonded pH sensible polymers. Different polymers can be selected so they detach from the particle at low pH, releasing the drug at the tumoral site. Among these systems, one of the most commonly used methods is based on polyelectrolyte multilayers. These gatekeepers are based on the layer-by-layer technique (Figure 5).43–45 The composition, thickness or the molecular organization of the layers46 and the permeability/elasticity of the polymers can be modified so the system can be easily “tuned”.47 Feng et al synthesized MSPs coated with multilayers of Poly(Allylamine Hydrochloride) (PAH) and Poly(Styrene Sulfonate) (PSS) polyelectrolytes, loaded with DOX inside the pores.48 In this study, they demonstrated that the delivery of the drug was both pH and layer thickness dependent, and that the layer thickness has an exponential relationship with the number of polymer coats applied. This study also demonstrated that i) the biodistribution of the drug in vivo was smaller in major organs compared to that of free DOX, and that ii) these particles had lower systemic toxicity than free DOX, thus, concluding that these MSP-based nanoparticles were a good carrier system with high efficiency and low systemic toxicity. Also, Sun et al used multilayer-coated MSPs to load cisplatin and Rhodamine B (RhB).49 The outer polyelectrolyte multilayer was assembled from the cationic polyelectrolyte PAH, and a second negatively charged polyelectrolyte, P(DMA-co-TPAMA), consisting of N,N-Dimethylacrylamide (DMA) and 3,4,5,6-Tetrahydrophthalic Anhydride functionalized N-(3-Aminopropyl) Methacrylamide (TPAMA) monomer units, that exhibited pH-induced charge conversion characteristics. This way, cisplatin and rhodamine B were released in the tumor microenvironment upon a pH reduction from 7.4 to 5–6, typical in malignant tumors. Other interesting gatekeeper systems are based on pH-sensitive linkers. These linkers are cleaved in acidic conditions, triggering the release of the cargo from the carrier. Acetal bonds,50–52 hydrazine bonds,53–55 hydrazone bonds56,57 or ester bonds58,59 are some examples that have been used worldwide. In a study carried out by Ze-Yong Li et al, DOX was conjugated to MSPs using hydrazine bonds.60 They proved that when the particles were in vitro incubated at pH 6.5, a fast DOX release occurred due to the hydrolysis of the bonds. Lee et al were able to attach DOX to the inner wall of MSPs and release this drug in the endolysosomes of cancer cells in the liver.61 The conjugation of the drug was done by hydrazone bonds that released the drug upon endo-lysosomal maturation when the pH of the vesicles decreased.
- Enzyme-responsive systems
Figure 5 Scheme of the layer by layer technique in mesoporous silica particles.
Compared to healthy tissues or cells, many different enzymes, mostly proteases, are overexpressed by cancer cells.62 This peculiarity can also be an interesting stimulus to trigger enzyme-mediated drug release.63 The development of enzyme-released drug delivery systems based on MSPs has caught much attention. Liu et al used in their study a Matrix-Metalloproteinase (MMPs) responsive drug delivery system based on MSPs to reduce in vivo side effects of traditional chemotherapies.64 MSPs were loaded with DOX and coated with bovine serum albumin as an end-cap to seal the mesopores of the nanoparticles, using lactobionic acid as the targeting motif. The in vivo experiments showed that the DOX delivery system could be used to inhibit tumoral growth in mice with minimal side effects.
- Redox-sensitive systems
Glutathione (GSH) is the most abundant non-protein thiol that acts as a reducing agent maintaining enzymes in an active state. In cancer cells, the intracellular concentration of GSH is three times higher than in normal cells.65 Hence, this is a good tool to prompt the release of drugs. Disulfide bonds66-70 (S-S) can be easily cleaved in the presence of GSH for being a redox-sensitive group, so they can be used to form capped systems with nanoparticles71,72 or polymers69,73,74 for instance. Gong et al were able to synthesize MSPs functionalized with polyethylene glycol using a disulfide bond linker.74 These authors demonstrate drug release upon GSH rise, while low GSH concentrations blocked the release. Apart from PEG,75,76 poly N-acryloxysuccinimide77 has also been used as an efficient method to deliver hydrophilic drugs to cancer cells improving the efficacy of the therapy.
External stimuli for drug delivery
Magnetic fields and light are external stimuli also used to control gatekeepers. Although these stimuli are less popular than endogenous stimuli, they are more reproducible and do not depend on the heterogeneous physiological conditions of the tumoral environment. Besides, these systems can be more precise in local drug release, minimizing toxicity and side effects.78 The two main strategies of these drug delivery systems are based on magnetic fields and light.
- Magnetic fields
These drug delivery systems are based on the use of magnetic fields as external stimuli to guide the particles to the tumor environment and to locally increase the temperature, triggering cell death by controlled drug release and/or hyperthermia.79 Superparamagnetic iron oxide nanoparticles are the most used magnetic nanoparticles. They exhibit an extraordinary capacity to convert magnetic energy into heat.80,81 This ability allows the use of thermo-sensitive materials as gatekeepers capping the surface of MSPs, provoking the opening of the pores and the release of a drug using magnetic fields.82,83 Baeza and colleagues used a nanodevice based on MSPs with iron oxide nanocrystals inside the silica matrix.83 This device was coated with a copolymer of Poly(Ethyleneimine)-b-Poly (N Isopropylacrylamide) (PEI/NIPAM), which acts as a temperature-sensitive gatekeeper and retains proteins into the polymer shell linked by electrostatic forces or hydrogen bonds. Once these nanodevices are administrated into cancer cells, an alternative magnetic field is applied. The results demonstrate that the polymer can act as a gatekeeper, opening or closing the pores of the silica matrix, controlling the release of the macromolecules attached to the polymer branches. Moreover, Thomas et al used in their study DOX-loaded MSPs combined with magnetic nanocrystals that have been surface-modified with pseudorotaxanes.84 After the application of a magnetic field, the nanocrystals generate heat, causing the disassembly of the pseudorotaxanes, triggering the release of DOX and consequently, a cytotoxic effect in breast cancer cells.
Among the external stimulus, light is a rapid, non-invasive, clean and efficient stimulus that can be used to control drug delivery with high spatial and temporal resolution.85,86 Although most photoreactions used in drug delivery are induced by UV light,85,87,88 the best wavelengths for good tissue penetration are those in the close IR, between 800 and 1,100 nm, which correspond to the so-called “water biological window”.89 The mechanism of these types of carriers to trigger drug release is based on the photo-sensitiveness of the gatekeeper that changes conformation upon light application. Guardado-Alvarez et al used MSPs with photolabile coumarin-based molecules capping the surface, noncovalently conjugated β-cyclodextrin to block the pores and rhodamine B inside the pores.90 This way, 800-nm two-photon excitation triggered the release of the bond holding the coumarin to the nanopore releasing both the β-cyclodextrin cap and the cargo. Martínez-Carmona and colleagues carried another study in vitro using an MSP-based device with porphyrin-caps attached with reactive oxygen species (ROS)-cleavable linkages.91 These bonds are sensitive to singlet-oxygen produced after exposure to visible light, releasing the cargo (Topotecan). The oxygen molecules produced by the porphyrin–nanocaps break the sensitive-linker uncapping the pores and releasing the entrapped drug. These particles have been used in osteosarcoma cancer cells demonstrating a controlled release of Topotecan inside the tumor cells. Another light-sensitive gatekeeper type is based on gold nanoparticles (AuNPs). These particles, combined with MSPs, are attractive devices for cancer cell imaging92-94 and can also heat when irradiated with a laser producing a photothermal effect.93 As for the magnetic nanoparticles, the heat generated upon light exposure can be used to release the anti-cancer therapy and/or trigger drug release. Wang and colleagues, for instance, designed a therapeutic delivery system, based on MSPs closed by AuNPs with RhB as the cargo.95 This carrier was studied in vitro showing a good release of the RhB when temperature increased. In the study done by Vivero-Escoto et al AuNP-capped-MSPs were useful to release a chemotherapeutic such as paclitaxel in human fibroblast and liver cells.96 This release could be easily controlled by low-power photoirradiation under physiological conditions.
Concerning the use of internal and external stimuli, it is important to mention the combination of both types of stimuli, light and alternating magnetic fields, to generate heat, to induce local hyperthermia increasing the pH97 and the enzymatic activity98 of the cells. Hence, this type of structured nanomaterials can be used as an interesting system for programmed site-specific drug delivery.
Triggering endolysosomal escape
Upon receptor-mediated endocytosis, MSPs are incorporated inside the endolysosomal membranes. Many nanoparticles after intracellular transit are eventually expelled from the cells by exocytosis.99–101 Thus, to avoid therapy degradation in the lysosomal due to the hostile chemical conditions and/or, exocytosis, nanocarriers need to escape into the cytoplasm. Thus far, different strategies have been developed to trigger lysosomal escape among these, the proton sponge effect102 and destabilization of the endosomal membrane are the most used.103 The first mechanism is based on the swelling of the vesicle, and the second, in the creation of pores that enable therapeutic release into the cytoplasm.
The proton sponge effect
This effect relies on the rise of the proton concentration during hydrolysis that, in turn, causes an increase in the membrane potential, osmotic swelling and finally endo-lysosome bursting.104 This phenomenon occurs when polyplexes such as PEI or PAMAM are endocytosed. The amine groups of these molecules capture protons that accumulate in endosomes, gradually increasing the membrane potential and breaking the lysosomal membrane equilibrium. The diffusion of Cl− molecules into endosomes cause the increase of the osmotic pressure, swelling, expanding and finally tearing the lipid bilayer of the endolysosome, releasing the contents into the cytoplasm (Figure 6).102 The MSPs used by Wu et al could release siRNA and DOX into the cytoplasm of breast cancer cells in vitro and in vivo using a Poly-β-amino ester coating to provoke endolysosome bursting.105 The work carried out by Shen et al demonstrated that MSPs coated with PEI cannot only carry a siRNA but also deliver it to xenografted tumors, reducing the size of the tumoral mass.106
Destabilization of the endosomal membrane
Other mechanisms to trigger particle endo-lysosomal escape are fusion lipids, cationic polymers, peptides107 or carbon nanotubes.103 In the study performed by Zhang et al, they synthesized polymer-lipid supported mesoporous silica nanoparticles (PLS-MSPs).108 These nanocarriers were able to release the anticancer drug (CPT -11) and maximize the effect of the treatment in MDR breast cancer cells. Apart from fusion lipids, many cell-penetrating peptides (fusogenic peptides) are being used based on bacterial or viral proteins. These peptides trigger vacuole-based endocytosis and/or to create discontinuities or pores on the cell membrane.109,110 For instance, Li and colleagues used MSPs coated with PEI and a fusogenic peptide to deliver siRNA to a tumor model showing an inhibition of the tumoral cell proliferation.111 Likewise, in some of our studies, we show how silica nanoparticles, when coated with multi-walled carbon nanotubes (MWCNT), can escape the endo-lysosomal route mimicking the viral spike fusion in lysosomes. The hypothesis is that proteins functionalizing the MWCNT surface are degraded in endolysosomes, exposing the surface of the nanotubes that are highly reactive and apolar. These stripped filaments now interact with the membrane of the endo-lysosomal vesicles, piercing and tearing it apart, triggering particle release into the cytoplasm (Figure 7).103
Last, but not least, one of the most important features of MSPs is their biocompatibility. Different studies have demonstrated that silica nanoparticles are not toxic when administrated to different cell types at different dosages.99,112–114 Furthermore, there are several reports demonstrating that MSPs are degradable in water and in phosphate buffer saline.13,14 There are different parameters that can trigger MSPs in vitro degradation including i) particle morphology,115 ii) surface area116 and iii) surface functionalization117,118 among others. For instance, spherical particles are more degradable than with rod-shaped particles.115 Similarly, particles that have a high surface area are more degradable.116 Interestingly, the MSPs size is apparently not all that important in degradation in water or simulated body fluids.119,120 Moreover, MSP and their fragments have also been reported to be eliminated by renal clearance, in urine, and/or feces.113,121,122 Interestingly, positively charged MSPs are cleared faster than particles with a negative ζ potential. Also, PEGylated MSPs show a higher in vivo circulation time, since PEG avoids macrophage recognition and phagocytosis in the liver and spleen. Other studies are now developing to improve the interactions of nanomaterials with blood components. For instance, Roggers et al have demonstrated that the functionalization of MSPs with different lipids can be used to imitate red blood cell lipid membranes, improving their hemo-biocompatibility.121
Drawbacks of MSPs
Ideally, nanoparticles need i) to be stable, ii) to have a high loading capacity, iii) to be reproducible and iv) scalable in production. Reproducible MSPs synthesis is reasonably feasible when working at small scale, but the scaling up is not trivial therefore, reproducibility at industrial scale must be critically considered. Regarding the loading capacity of MSPs, not all drugs can be incorporated at an adequate concentration, and this critically influences the total concentration of nanoparticles that should be administrated to obtain an effective therapeutic effect. For instance, the tolerated dose of uncoated MSPs in murine models is ca. 50 mg/kg, but the human tolerance is so far unknown and needs to be evaluated.122 Also, most biodistribution and excretion studies have been performed in mice123 and must be reproduced in humans to understand the immune response and possible side-effects of these nanomaterials.
Another important point regarding the use of MSPs in clinical trials is the fact that the Food and Drug Administration and the European Medicines Agency must evaluate drug delivery nanocarriers before bench-to-bed translation, even if loaded with drugs already approved for clinical use. This is a slow procedure that significantly delays all new developments in nanodelivery. Hopefully, soon new requirements will be developed to accelerate the translation from research to the clinic.
The field of nanotechnology is gaining a high interest in cancer medicine. MSPs can be customized on demand in order to engineer nanocarriers that can i) target cells specifically, ii) release drugs inside the desired tissues/cells reducing the side effects of the treatment, iii) invade the cytoplasm by scaping the endo-lysosomal membrane, so that the cargo is preserved and finally iv) be biodegraded or cleared from the organism to minimize toxicity. Although MSPs are being widely studied as nanocarrier systems in animal models to ensure they are safe, more research is needed in the field of nanodelivery in cancer.
This work has been supported by the Spanish MINECO and European Union FEDER Funds under Project Ref. PI16/00496 (AES 2016), CTM 2017-84050-R, MAT 2015-69508-P, NanoBioApp Network (MINECO-17-MAT2016-81955-REDT), Xunta de Galicia (Centro Singular de Investigación de Galicia - Accreditation 2016-2019 and EM2014/035), European Union (European Regional Development Fund-ERDF) and IDIVAL INNVAL15/15 and INNVAL17/11.
Images have been produced using the free software available at:
The authors report no conflicts of interest in this work.
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103. Iturrioz-Rodriguez N, González-Lavado E, Marín- L, Araújo BV, Pérez-Lorenzo M, Fanarraga ML. A biomimetic escape strategy for cytoplasm invasion by synthetic particles. Angew Int Ed Chemie. 2017;56(44):13736–13740. doi:10.1002/anie.201707769
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107. Ma D. Enhancing endosomal escape for nanoparticle mediated siRNA delivery. Nanoscale. 2014;6:6415–6425. doi:10.1039/c4nr00018h
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domain: literature


text:
National women' history project, © nwhp 2009: users are invited to use any and all of our web content, as long as credit is cited to the national women's history project. Bria 20 2 women won vote, Constitutional rights foundation bill of rights in action spring 2004 (20:2) developments in democracy. bria 20:2 home | how women won the right to vote | have women. A historical timeline afghanistan | updates | pbs, The land that is now afghanistan has a long history of domination by foreign conquerors and strife among internally warring factions. at the gateway between asia and.
Timeline african-american civil rights movement, This timeline african-american civil rights movement, freedom movement gain equality african americans culminated 1950s 1960s.. http://en.wikipedia.org/wiki/Timeline_of_the_African-American_Civil_Rights_Movement Women' history timeline | www.bloomu., You . home. womens resource center; involved; ; victim advocacy. http://www.bloomu.edu/wrc/timeline Women' history timeline - topic search | www.bloomu., You . home. womens resource center; involved; ; victim advocacy. http://www.bloomu.edu/wrc/timeline_topic


text:
NSF Budget to Reach $3.2 Billion in FY 1995
CRS at ANDREW.STANFORD.EDU
Fri Feb 18 20:22:47 EST 1994
Sender: smacklin at nsf.gov
------------------------------- Message Contents -----------------------------
National Science Foundation February 7, 1994
NSF PR 94-4
NSF BUDGET TO REACH $3.2 BILLION IN FISCAL YEAR 1995
PRESIDENT SEES AGENCY BUDGET AS AN "INVESTMENT"
Neal Lane, director of the National Science Foundation (NSF), today
February 7) announced that the Clinton Administration has proposed
year 1995 budget of $3.2 billion for the National Science Foundation
$182.2 million increase over the 1994 budget of $3.02 billion.
According to Lane, the six percent increase for NSF reflects the
administration's priority "to make an investment in the nation's
technology capabilities, an investment which is critical to our future
He added that while the agency's budget is about four percent of the
federal investment in research and development, NSF supports
percent of all basic research at academic institutions when
research support is excluded.
Lane said that NSF plays a central role in sustaining the nation's
capabilities because of its considerable investment in the
research enterprise, activities at the core of U.S. capabilities in
mathematics, and engineering. In addition, he said that
research is a primary source of both new knowledge and the setting
future generations of scientists and engineers are trained.
RESEARCH FOCUSSED IN STRATEGIC AREAS
According to the NSF Director, the amount requested for NSF's
its research and research-related account is $2.348 billion, a $180
or 8.3 percent increase above this fiscal year.
Lane said the Foundation is increasing its emphasis on inter-agency
directly tied to national priorities. These initiatives--which cross
disciplinary boundaries, government agencies, industrial sectors,
international borders--focus primarily on strategic areas because of
benefits they can provide to the nation.
While these initiatives can be found in several areas, the most
global change, and high performance computing and communications
Funding for global change research will raise from $141.9 million to
$207.5 million, an increase of more than 46 percent, and will be
better understanding fundamental physical, geological, biological,
socioeconomic processes. Specific research activities will include
international data collection and analysis; climate change modeling
forecasting; and the development of policies related to climate
High performance computing and communications will increase from
million to $328.6 million, an increase of more than 23 percent. This
initiative will wed advanced computing and communications
research and education in all areas of science, engineering, and
Two key aspects of this initiative involve developing networks for
and secondary schools, and harnessing the most advanced
computers to study
"grand challenges," i.e., complex problems such as weather
understanding the formulation of galaxies.
Additional investments will be made in other important research
areas such as
advanced manufacturing technology, advanced materials,
infrastructure systems, and environmental research.
SCIENCE, MATHEMATICS, ENGINEERING, AND TECHNOLOGY
Lane said that the budget for NSF's education and human resources
totals $586 million, about a three percent increase above last year.
that this level of funding will continue to keep the Foundation at the
forefront in improving the nation's scientific and technological
enterprise, and "strengthens the scientific and technical workforce by
raising the scientific literacy of all Americans."
He cited systemic reform and advanced technology education as two
examples of NSF emphasis.
Nearly $86 million will go toward the agency's systemic reform
These activities, targeted at state, urban, and rural school systems,
them with different levels of government, academic institutions, local
businesses, museums, and other organizations. The objective of
effort is to significantly alter the education of K-12 students in
mathematics, engineering, and technology.
The second area, advanced technology education, was an initiative
in fiscal year 1994. The objective of this effort is to provide support
the nation's two-year colleges so that they can provide a better
students not currently in a more traditional academic track.
Lane added that the agency's on-going efforts to assess its
training programs will continue to be a "high priority" during the
fiscal year. "After several years of substantial growth, we need to
critical look at these important programs to ensure that our
them are as effective as they can be today and in the future," Lane
Lane summarized the $3.2 billion investment as one that
and education activities to address major underlying issues facing
society--competing in world markets, mitigating threats to the
improving efficiency in all sectors, educating citizens, and improving
quality of life for all Americans. Through these activities, the
will directly support an estimated 150,000 individuals at all levels in
ranging from students to teachers to mathematicians and to
More information about the Arab-gen

domain: economics


A Secret Weapon For alternator repair toledo ohiowikiHow Contributor If you know how to rebuild it, try to look for the rebuild package in your neighborhood automobile parts shop or go on automobile-parts.com. You should purchase a utilised one with guarantee for under what you'll buy a brand new one or simply a remanufactured just one.
FYI, mark the shaft the place it satisfies the housing to ensure that when you put in the bearing powering it You simply thrust it down in terms of the housing hits the mark. If not, in case you force the bearing the many way down against the rotor, the brushes will possible hit the housing or the housing is not going to in fact relaxation about the bearing.
It is significant the alternator operates efficiently, looking at that the battery provides electricity to A variety of elements.
During the party it fails, the car could run properly for a while thanks to the existing charge inside the battery – but when the battery Electrical power is depleted, you’ll begin to knowledge some critical challenges.
Never ever disconnect the battery within the motor vehicle if the engine is working. The battery absorbs extra voltage with the alternator and with no it, the upper voltage may possibly demolish the automobile's electrical and electronic elements.
Patrick was also great, organising the get for exact evening and work was completed in a short time. Car or truck was picked up on Thursday and returned on Saturday. Full approach was anxiety free of charge. Thanks. Oh plus the clutch operates wonderful now!
SLIP RINGS: These are two circles of copper hooked up to the shaft of the rotor. Wires join them to either conclusion of the rotor field coil.
In Alternators How do you resolve a brief circuit within an alternator? more helpful hints Alternators are normally not person repairable. It's going to take specialtools and entry to parts to repair. Whilst you'll find repaircenters, it could be more cost-effective to only exchange it.
I do make loads of limited drives n It really is a2009 Toyota RAV4 with every one of the bells n buzzers . Can that vehicle shut off if lights and many others be draining the battery regardless if car or truck is off..need to I be manually shutting them off
When replacing the alternator, the technician should take away the battery cables to stop electric powered shock. Afterwards, the accent push belts or serpentine belts need to be removed from the alternator, coupled with electrical connectors, and a number of other bolts.
S.A.P.! Also watch your temperature gage! Maybe you have damaged a belt, and This may bring about your motor to overheat. Should really the vehicle overheat, you ought to cease once safely and securely probable. Either test it out you or get it to the mechanic for repair. Particular Be aware to air cooled V.W. Beetle owners and Corvairs (Indeed, there are still some close to!!): the alternator or generator belt turns your cooling lover, so if the light will come on, check the belt quite soon: it might severely overheat in an extremely jiffy!
Most reconditioned alternators come with no less than a one-year warranty, Although some have a guarantee for up to a few a long time. Some new alternators may well have a limited lifetime guarantee. Check together with your mechanic to find out how prolonged the warranty is and what it addresses.
In the 1st scenario, the problem could be the battery - possibly It can be no excellent or it doesn't have ample electrical power and must be charged- the starter coil (which might go poor and involve alternative), or maybe the starter by itself.
The more than likely would be that the starter has come loose as a consequence of a free bolt or perhaps a damaged bell housing to the transmission.


text:
EOG Resources (NYSE:EOG)
Historical Stock Chart
1 Year : From Feb 2019 to Feb 2020
By WSJ City
Norway's sovereign-wealth fund is embracing renewable energy and winding down fossil-fuel investments after parliament instructed the fund, built on oil profits, to redirect investments in smaller firms.
-- Norway's parliament asked its $1 trillion fund to pull an estimated more
-- ...from oil, gas and coal extracting companies, and move up to $20bn into
renewable-energy projects and firms.
-- The Government Pension Fund Global has around 6% of its holdings in
-- It won't pull investments from major oil companies, but will divest from
smaller energy firms.
-- The fund is one of the largest in the world, investing in nearly 9,200
Why This Matters
The divestment comes as government pension funds face pressure to realign their strategies around green businesses and clean energy to meet the goals of the Paris Agreement on climate change. The move could affect several of the fund's US investments including its 1.08% stake in Anadarko Petroleum, 0.98% in Occidental Petroleum and 0.96% in EOG Resources.
The decision also reduces financial risk because the oil-and-gas industry is no longer as profitable since the oil-price drop in 2014.
A fuller story is available on WSJ.com
WSJ City: The news, the key facts and why it matters. Be deeply informed in less than five minutes. You can find more concise stories like this on the WSJ City app. Download now from the App Store or Google Play, or sign up to newsletters here http://www.wsj.com/newsletters?sub=356&mod=djemwsjcity
(END) Dow Jones Newswires
June 13, 2019 08:21 ET (12:21 GMT)
Copyright (c) 2019 Dow Jones & Company, Inc.


text:
Bar inside the Restaurant
Geno’s boasts it has “Eau Claire’s best pizza,” but it’s got a full bar, too. Wash down your favorite Italian pie with a wide selection of craft and domestic brews on tap. If you’re of drinking age and are looking for something sweet, order up a Not Your Father’s Root Beer Float.
Visit the Geno's Pizza bar page for more details »

domain: food


text:
GIG REVIEW: FEAR FACTORY & SOILWORK Live at Rams Head Live, Baltimore
Dawn 'Mama Love' Brown
On a rather chilly spring evening, a modest crowd gathered to witness Fear Factory’s ‘Demanufacture’ tour at Rams Head Live in Baltimore, MD., supported by Soilwork, Spades and Blades and Martyrd. Presumably, ticket sales for this show were lackluster as patrons of the previous day’s Baltimore Orioles Opening Day game were offered free admission to the show upon presenting their game ticket. It’s not clear how many baseball fans took advantage of the offer, but the audience did fill in nicely as the show progressed.
Opening the show was Martyrd, a 5-piece crew of gentlemen out of New York, NY. Martyrd definitely delivered a spirited performance, barging their way through songs like “The Mortal Coil” and “The Faceless”. Aaron Pollard’s vocals were slightly hard to hear, but when they were audible, they were clean and strong. Married with the double guitar threat of the two Mikes, Michael Andreas and Mike Kitsos, respectively, Brian Nichols on Bass and Randall Lee on drums, Martyrd is a force to be reckoned with. Keep your eyes on these guys.
Next up was Spades and Blades, a four-man band out of Los Angeles, CA. Cited as an LA Metalcore group, S&B pounded out riff-heavy selections from their latest album, ‘The End is Near’, such as “Domination” and “Isolation”. Vocalist Jason Todd tried to get a circle pit going but the crowd just didn’t bite. They still enjoyed a great fan response with the requisite jumping and head banging. Backed up by Justin Bullock on guitar, John Douglas on bass and Tommy Jean Stiles on drums, Spades and Blades dished out crunchy riffs and commanding melodies. Another band to keep an eye on.
Appearing next was melodic death metal giants, Soilwork. This band always gives an epic performance and this evening was no exception. Barreling through an eclectic mix of songs old and new and opening with “The Ride Majestic”, Soilwork commanded the stage as they always do. Bjorn “Speed” Strid’s vocals were stellar and Sylvain Coudret’s intricate guitar work shined on stage, effectively negating the unique faces Sylvain makes while he plays. Ronny Gutierrez, filling in for Dave Andersson on guitar, killed it and fit in harmoniously with the rest of the band, rounded out by Sven Karlsson on keys, Dirk Verbeuren on drums and Markus Wibom on bass. A humble but active pit finally erupted during “Follow the Hollow” and continued sporadically throughout their remaining set.
Headlining the night’s festivities was Fear Factory, descending onto the stage flanked in blue lighting which made for less than ideal photo conditions but added a slightly sinister vibe to the overall performance. Fear Factory opened with “Demanufacture” and continued headlong into the album in its entirety. This was a real treat for diehard FF fans. The crowd response waxed and waned revealing which songs were fan favorites. After a brief respite off stage after finishing the ‘Demanufacture’ set, the guys came back with an assortment of tracks from their various studio albums including “Edgecrusher”, “Soul Hacker” and “Dielectric”. Closing out with “Martyr”, Fear Factory delivered a crushing performance with Dino Cazares dominating the stage with searing riffs and groovy hooks. Burton Bell on vocals seemed slightly subdued, but Mike Heller’s thunderous drums and Tony Campos’ technical bass lines blended skillfully resulting in a heavy metal fracas enjoyed by all.
Bottom Line: Great show. I’m not sure why at least one band at all shows has to have sound mixing issues. Next time, just turn up the vocals!


text:
Video: Coast Guard rescues man from cliff near Port Angeles
PORT ANGELES, Wash. - A U.S. Coast Guard crew rescued a 31-year-old man after he fell from a cliff near Port Angeles Monday afternoon.
The crew from Coast Guard Sector Puget Sound was dispatched to the scene around 12:19 p.m. after reports that the man had fallen and had multiple broken bones.
When the helicopter crew arrived, the crew hoisted the man from the cliffside, along with an ambulance medical technician who was helping him.
The man was taken to Harborview Medical Center in stable condition.
Port Angeles Police are now investigating the incident.


Training up on MRAPs
October 18, 2010
FORT HOOD, Texas - Soldiers with 3rd Brigade Combat Team, 1st Cavalry Division conducted training on mine-resistant, ambush protected vehicles recently in order to stay up-to-date on equipment used in combat today.
According to the website, Globalsecurity.org, MRAPs are a family of vehicles that generally incorporate a "V"-shaped hull and armor plating designed to provide protection against mines and improvised explosive device. There are three categories of MRAP weighing between seven and 22 tons, and capable of carrying between six and 12 personnel.
Troops prefer the MRAP to the humvee because of the smoothness of the ride and the air conditioning, but mostly because of the survivability rate, said course instructors.
"This vehicle is designed that if it hit an IED, the Soldiers inside will be pretty shook up, but they'll be OK," said David Miller, a government contractor that provides operator and maintenance training on the MRAP vehicle family.
During training, Soldiers gathered at the brigade motor pool for the four-day course and completed classroom, hands-on and night training to familiarize themselves with the vehicles.
They learned about safety and cautions of the vehicle, how to operate and maintain it, how to maneuver the vehicle as well as how to drive it at night.
Leaders there said the training is vital to the success of a deployed unit.
"This is a vehicle that has saved lives in the past in both Iraq and Afghanistan," said Sgt. Michael Leguillow, with Headquarters and Headquarters Company, 215th Brigade Support Battalion, from Carolina, Puerto Rico. "It's great for them to understand the vehicle and how to take care of it down-range."


text:
Chintu Ji, the movie starring Rishi Kapoor, is supposed to release on
The low-key film has received postive initial reviews but it being available online even before it opens in the theatres might impact the film's earnings.
Produced by Bobby Bedi and directed by Ranjit Kapoor, Chintu Ji's starcast includes - apart from Rishi Kapoor - Priyanshu Chatterjee, Kulraj Randhawa, Saurabh Shukla, Grusha Kapoor and Sophie Choudhry.
Such leaks did not happen for the first time. Piracy is a major crisis for the Indian movie industry causing losses worth millions of rupees every year. Last year, when Rajasthan banned the release of Jodhaa Akbar in its local theatres, sales of pirated copies of the movie went up. Though Indian government and the production houses are trying their best to curb piracy but the situation did not change much over time.


New App Helps Farmers in Kenya Find Climate-Smart Seeds
Friday, June 19, 2015
A new app launched in Kenya June 10 could help millions of farmers adapt to climate change by offering information on the best seeds for changing growing conditions, agriculture experts said.
Agriculture accounts for more than 70 percent of Kenya’s employment, according to U.S. government figures, so an increase in food production would dramatically improve living standards.
The free “MbeguChoice” app is the first tool of its kind in sub-Saharan Africa, and was developed by a 25-year-old Kenyan software engineer. “MbeguChoice” means seed choice in Swahili.
It comprises an online database, which is also available via a website, and could be expanded to other countries if its roll-out proves successful, officials behind the project said.
“The platform provides information on special characteristics [of different kinds of seeds] for drought tolerance, and the best altitude and area for growing a particular crop,” Philip Leley, an adviser to the United Nations’ Food and Agriculture Organization who gave the developers technical information, said in a telephone interview from Nairobi.
If a farmer in the mid-altitude region of Makueni County, for example, searches for drought-tolerant corn varieties to plant during the rainy season, the app would show five kinds of seeds the grower could buy which would do well in that area.
The online database, containing more than 200 crop varieties, is backed by seed producers who believe it will help drive business.
Source: The Christian Science Monitor (link opens in a new window)
- Agriculture, Environment, Technology


text: It was a happy accident that led Ian Burke to an exhibition of ‘Boro’ textiles a couple of years ago. He thought it had something to do with his beloved Middlesbrough football team! Actually ‘Boro’ (meaning ‘ragged’) refers to the Japanese peasant tradition of recycling fabrics using indigo dyes, patchwork, weaving and embroidery. Ian was fascinated by their simple beauty. The completed textiles are themselves happy accidents, dictated by the nature and condition of the materials available rather than the maker’s design. He responded to the exhibition by experimenting with his own ‘Boro’ collages, using oil paint and print-making as well as textiles and incorporating shapes that will be recognisable to anyone familiar with his work. Propellers, cobles, tractors, lobsters are all discernible (if in abstract form) in these stunning canvases.


text:
Following the recent funding award under the Singapore Food Agency’s ‘30x30 Express’ Grant to build its next mega-farm in Singapore by Q4 2021, &ever is pleased to announce that its Global R&D Center will be located in Singapore with the support from the Economic Development Board. &ever has entered into collaboration with Signify and plans to work with A*STAR and local academic institutes to explore research collaborations, whereby multiple research activities will focus on reducing energy consumption and optimizing yield in &ever’s indoor vertical farms. The first project will focus on hybrid lighting systems, a sustainable smart combination of sunlight capturing systems with next-generation LED grow lights.
Singapore – November 2020 – &ever today at the Asia-Pacific Agri Food Innovation Summit, a virtual industry event, announced the setup of its global R&D center in Singapore. The facility will be collocated with &ever’s new mega-farm in Changi, which will go live in Q4 2021.
In order to employ and refine sustainable practices, indoor vertical farms must make use of the most efficient lighting technologies on the market. Therefore, &ever teams up with Signify, a true innovator in horticultural lighting. Experiments will be carried out in &ever’s large-scale farming environment to continuously minimize electricity consumption, while optimizing taste profile and yield.
Another research project in the field of energy-saving solutions is to optimize hybrid lighting solutions in controlled indoor environments with the ultimate goal to develop a system which makes the best use of natural sunlight in closed systems, while only adding artificial light based on the plants’ requirements. &ever has plans to partner with the Agency for Science, Technology and Research in Singapore, on this.
By teaming up with local higher learning institutions and established industry players, the R&D center will harness on the innovation potential for new climate control concepts and advanced LED technologies, most optimal seeds and substrate combinations as well as vision control and noninvasive crop monitoring solutions.
“Energy efficiency and sustainability are key differentiators of &ever’s approach to indoor vertical farming,” says &ever’s CEO Dr. Henner Schwarz, “and we continue to research the field to further enhance our farms.” “We look forward to the establishment of our first farm in Singapore and our Global R&D Center as the first of many efforts within Singapore as well as throughout Asia”.
“&ever brings with them leading capabilities, technologies and a spirit of innovation, which will contribute to the vibrancy of urban agriculture R&D capabilities in Singapore. This is in line with EDB’s efforts to develop Singapore as a leading hub to develop and commercialise Agri-Food technology solutions that can sustainably feed the world,” said Damian Chan, Executive Vice President and Member of EXCO, Planning and Policy.
Building on &ever’s capabilities and tapping on Singapore’s vast research network, the company will contribute towards the country’s “30 by 30” goal of producing 30% of Singapore’s nutritional needs locally by 2030. In that respect, &ever had announced its plan to build a mega-farm with 500+ tons annual production capacity in Singapore with the support of SFA under its ‘30x30 Express’ Grant about a month ago.
By creating seamless automation from seeding to harvesting and full digital control over the production process, &ever creates intelligent sustainable farming systems of the future; whereupon its R&D center will enable leading local engineers and scientists to create even more efficient and sustainable systems and processes.

domain: geography


text:
The Macallan Concept No 1
Whisky Region: Speyside Whisky
This is the first of The Macallan Concept releases. It celebrates the world’s visionaries by daring to disrupt the whisky making process.
Exclusive to travel retail market, The 2018 Macallan Concept Number 1 is inspired by surreal art and incorporates innovative production techniques to create an exciting new single malt.
Created from whiskies matured first in sherry-seasoned oak casks and then for an equal time in ex-bourbon casks, this single malt is crafted to explore maturation more imaginatively.


|Team: Creighton, Freshman|
H: 6' 11"|
W: 215 lbs
(19 Years Old)
|Pick: 16 in 2017 Mock Draft |
Rank 17 in Top 100 Prospects
Rank 22 in NCAA Freshmen
Rank 19 in Top Big East Prospects
High School: Omaha North HS
Hometown: Omaha, NE
Julian Applebome takes a closer look at Justin Patton's 18-point, 8-rebound, 2-block performance against then-undefeated and #1 ranked Villanova.
The 19-year old redshirt freshman big man has been a revelation for top-ten ranked Creighton so far this season, averaging 20 points, 10 rebounds, 2.2 blocks and 1.5 steals per-40, in 25 minutes of action. He's shooting an outrageous 76% for 2 thus far, and is even 5/8 from beyond the arc.
While Patton was very much an under the radar prospect coming into Creighton, a product of his late-blooming status in high school and subsequent decision to redshirt his first year, his combination of size, athleticism, budding skill and upside is is extremely interesting in the long term. While his frame is still a ways away from being NBA ready, he is already starting to draw quite a few looks from NBA teams and will continue to do so if he keeps producing like this over the next few months.
Julian Applebome is a video analyst for DraftExpress. Follow him on twitter and check out the DraftExpress Video section. He will be breaking down the NBA draft in digital format all year long for us.


A semi-flex sanding disc is a type of abrasive disc that is typically used for sanding or finishing wood, metal, and other materials. The term "semi-flex" refers to the flexibility of the disc, which is designed to be more flexible than a traditional rigid disc. This added flexibility allows the disc to conform to the contours of the surface being sanded, which can result in a more even and consistent finish.
Semi-flex sanding discs are typically made of a flexible fabric or paper material that is coated with abrasive particles, such as aluminum oxide or silicon carbide. They are designed to be used with a special backing pad that is also flexible, which allows the disc to bend and flex as it is being used. These discs are typically used for sanding curves, contours and irregular surfaces
The grit size of the abrasive particles on the disc, it can vary.


text:
Dogs are pretty great, they're friendly, loyal, playful and super affectionate. What's not to love? I know that one of my favorite things about my parents' dog is how goofy he is. One thing that makes him especially weird is that he likes to curl up behind you on the back of the couch, almost like a cat! And this is not a small dog, he is a big guy. It is so strange, and he will start to slide down the couch cushion because he is too heavy but he doesn't let it bother him, he just naps away.
How sweet would that be? To be able to just nap through anything.
1. I like to imagine that he was smelling these and they smelt really bad.
2. Like, how can this even be comfortable?
3. Okay, I do totally know what this feeling is like.
4. Doesn't that hurt his little nose?
5. There are times when my apartment is this cold.
6. This little guy is just having the nap of his life.
7. This one is my favorite, I would love to nap with a bunch of baby piggies.
8. If I could nap in a shopping cart, I would.

domain: pet


Picture - Bob Burnquest greets fans as...
Bob Burnquest greets fans as he arrives at the X Games 2012 Los Angeles. The iconic pro-skateboarder had to be transported by mobility buggy after injuring his left foot the previous day. Los Angeles, California - 27.06.12
+ Photo Album: Bob Burnquest greets fans as he arrives...
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