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The scientists discovered that certain proteins, called extremely long-lived proteins (ELLPs), which are found on the surface of the nucleus of neurons, have a remarkably long lifespan.
This microscope image shows extremely long-lived proteins, or ELLPs, glowing green on the outside of the nucleus of a rat brain cell. DNA inside the nucleus is pictured in blue. The Salk scientists discovered that the ELLPs, which form channels through the wall of the nucleus, lasted for more than a year without being replaced. Deterioration of these proteins may allow toxins to enter the nucleus, resulting in cellular aging.
Credit: Courtesy of Brandon Toyama, Salk Institute for Biological Studies
While the lifespan of most proteins totals two days or less, the Salk Institute researchers identified ELLPs in the rat brain that were as old as the organism, a finding they reported today in Science.
The Salk scientists are the first to discover an essential intracellular machine whose components include proteins of this age. Their results suggest the proteins last an entire lifetime, without being replaced.
ELLPs make up the transport channels on the surface of the nucleus; gates that control what materials enter and exit. Their long lifespan might be an advantage if not for the wear-and-tear that these proteins experience over time. Unlike other proteins in the body, ELLPs are not replaced when they incur aberrant chemical modifications and other damage.
Damage to the ELLPs weakens the ability of the three-dimensional transport channels that are composed of these proteins to safeguard the cell's nucleus from toxins, says Martin Hetzer, a professor in Salk's Molecular and Cell Biology Laboratory, who headed the research. These toxins may alter the cell's DNA and thereby the activity of genes, resulting in cellular aging.
Funded by the Ellison Medical Foundation and the Glenn Foundation for Medical Research, Hetzer's research group is the only lab in the world that is investigating the role of these transport channels, called the nuclear pore complex (NPC), in the aging process.
Previous studies have revealed that alterations in gene expression underlie the aging process. But, until the Hetzer lab's discovery that mammals' NPCs possess an Achilles' heel that allows DNA-damaging toxins to enter the nucleus, the scientific community has had few solid clues about how these gene alterations occur.
"The fundamental defining feature of aging is an overall decline in the functional capacity of various organs such as the heart and the brain," says Hetzer. "This decline results from deterioration of the homeostasis, or internal stability, within the constituent cells of those organs. Recent research in several laboratories has linked breakdown of protein homeostasis to declining cell function."
The results that Hetzer and his team report today suggest that declining neuron function may originate in ELLPs that deteriorate as a result of damage over time.
"Most cells, but not neurons, combat functional deterioration of their protein components through the process of protein turnover, in which the potentially impaired parts of the proteins are replaced with new functional copies," says Hetzer.
"Our results also suggest that nuclear pore deterioration might be a general aging mechanism leading to age-related defects in nuclear function, such as the loss of youthful gene expression programs," he adds.
The findings may prove relevant to understanding the molecular origins of aging and such neurodegenerative disorders as Alzheimer's disease and Parkinson's disease.
In previous studies, Hetzer and his team discovered large filaments in the nuclei of neurons of old mice and rats, whose origins they traced to the cytoplasm. Such filaments have been linked to various neurological disorders including Parkinson's disease. Whether the misplaced molecules are a cause, or a result, of the disease has not yet been determined.
Also in previous studies, Hetzer and his team documented age-dependent declines in the functioning of NPCs in the neurons of healthy aging rats, which are laboratory models of human biology.
Hetzer's team includes his colleagues at the Salk Institute as well as John Yates III, a professor in the Department of Chemical Physiology of The Scripps Research Institute.
When Hetzer decided three years ago to investigate whether the NPC plays a role in initiating or contributing to the onset of aging and certain neurodegenerative diseases, some members of the scientific community warned him that such a study was too bold and would be difficult and expensive to conduct. But Hetzer was determined despite the warnings.
He adds that without foundation funding, the study would not have progressed to the point that its findings are published in a leading journal.About the Salk Institute for Biological Studies:
Faculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, M.D., the Institute is an independent nonprofit organization and architectural landmark.
Andy Hoang | EurekAlert!
Meadows beat out shrubs when it comes to storing carbon
23.11.2017 | Norwegian University of Science and Technology
Migrating Cells: Folds in the cell membrane supply material for necessary blebs
23.11.2017 | Westfälische Wilhelms-Universität Münster
Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
23.11.2017 | Information Technology
23.11.2017 | Physics and Astronomy
23.11.2017 | Life Sciences


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The son of a Major League pitcher and a former college baseball player himself, Chiefs' quarterback Patrick Mahomes returned to the mound last week to throw out the first pitch at a Royals' game.
The season continues to inch closer by the day as the first round of Organized Team Activities (OTAs) got underway on Tuesday. In anticipation of the three-day practice period, we continued to preview the competition at a handful of position groups.
The league meetings took place in Atlanta last week, where NFL owners adopted two new rules for the 2018 season. One of those rules is going to be obvious to everyone from the very first kick of the game, as there will be a major change to how kickoffs look in the NFL next season.
Chiefs' Head Coach Andy Reid and a handful of players spoke to the media on Thursday following OTAs. Before answering questions, Reid provided an update on the three players held back from the practices due to injuries.
There was plenty to be excited about throughout the first round of practices, including the flashes of talent from Chiefs' second-year quarterback Patrick Mahomes.
Last year, Patrick Mahomes, who was fresh off becoming the Chiefs' first quarterback selected in the first round of the NFL Draft in more than 30 years, spent his time at OTAs learning from Alex Smith and trying to understand the verbiage of the play calls.
It started with learning the protections and how to adjust, then reading the defense and how the routes changed with what the defense was showing, and many of the other "big picture" things that go along with playing quarterback in this offense.
And on Thursday afternoon, which featured both sides of Mahomes—the arm talent, and also the development that'll come, there were a handful of small things that showed his comfortability in the offense.
"He's way ahead of what he was last year at this time," Reid said. "He worked hard last year and was in a great room."
For more observations from OTAs, click here.
Another source of excitement from the practice period was the presence of safety Eric Berry, who missed almost all of last season with a ruptured Achilles tendon.
As one would expect from a guy like Berry, he doesn't have a waiting period to dispense the info he's attained throughout his career to the younger guys
"I'm dedicated to this team and if you're a part of this team, I'm dedicated to you," Berry added. "That's just how I roll…I know my teammates are dependent on me and I'm dependent on them. It's more of an accountability thing just to handle my business and make sure I'm ready to go just to make sure we can all do what we came here to do."
Check out the rest of the story here.
Off the field, 10-year-old cancer survivor Alex Goodwin toured Arrowhead Stadium earlier this week. The University of Kansas Health System was the only place in the world that told Alex, a native of the United Kingdom, that they could help him beat a Ewing's sarcoma diagnosis two years ago.
You see, Alex, a native of the United Kingdom, was told he was going to die. There was nothing the doctors could do after a six-month misdiagnosis revealed itself as Ewing's sarcoma.
"He had just turned nine," Jeff explained. "And they told us that he wouldn't make it to 10."
*An incredibly rare condition, Ewing's sarcoma affects less than 300 children in the United States – and less than 30 in Britain – each year. Its scarcity means that treatment is underfunded and, such as it is in the U.K., very difficult to find. *
That lack of services compounded with Alex's late diagnosis meant the odds of survival were virtually nonexistent.
It was a reality that Jeff, a police officer, was simply not going to accept. And as fate would have it, a tragedy a world away was going to lead his family to the only place capable of pulling off the seemingly impossible.
Read the rest of Alex's improbable journey here.
Alex Goodwin, a 10-year old boy from the UK receiving cancer treatment in Kansas City, getting a VIP tour of Arrowhead Stadium.

domain: news


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(AllHipHop News) Rapper Mystikal has settled a very big tax bill, thanks to a settlement with the IRS.
Last month, the rapper was hit with a lawsuit over a $2.9 million in back taxes on money he earned between 1997 and 2013.
Mystikal fought the bill and told the taxman his managers were to blame for the huge tab since he was in prison for a rape conviction during the bulk of the time in question.
A judge recently agreed to a settlement, so he will not have to stand trial over the dispute.
It is good news for the rapper, who is free on a $3 million bond for first-degree rape and second-degree kidnapping after a Louisiana woman accused him of sexual assault in 2017.
Mystikal has pleaded not guilty to the charges.

domain: finance


text:
CRL gathers and provides information here about commercial and open access digital resources of interest to the CRL community. This information is intended to inform library decisions on investment in electronic resources and related services.
Morningstar Direct is a cloud-based investment analysis platform. The subscription-based product provides access to Morningstar's data, analytics, and market research.
The product offers global data covering historical portfolio holdings, equities, separate accounts, hedge funds, ETFs, indexes, and real-time pricing. The product also includes analysis tools for researchers to use in utilizing the data.
Preqin databases contain data on the alternative asset industry. The databases cover: private equity, real estate, hedge fund, infrastructure, private debt and natural resources asset classes in the following areas: funds and fundraising, performance, fund managers, institutional investors, deals, and fund terms.
Indiastat is an online gateway to socio-economic data from India, its states, regions, and districts. Subscription to Indiastat provides access to 56 associate databases that cover topics including agriculture, demographics, market forecast, health, media, economy, crime, and social welfare.
The OECD iLibrary is the online library of the Organisation for Economic Co-operation and Development featuring books, papers, and statistics as well as OECD data and analysis.
Latinobarómetro is an annual public opinion survey that as of 2016 involved some 20,000 interviews in 18 Latin American countries, representing more than 600 million inhabitants.
The U.S. Census Bureau provides online, open access to statistics and analysis tools from multiple surveyors about the nation's people and economy. The Bureau collects data through several surveys including: the decennial census of population and housing, economic census, censuses of state and local governments, the American Community Survey, and other economic indicators.
UNdata is the online entry point to UN statistical databases containing over 60 million data points covering a range of themes including: Agriculture, Crime, Education, Employment, Energy, Environment, Health, HIV/AIDS, Human Development, Industry, Information and Communication Technology, National Accounts, Population, Refugees, Tourism, Trade, as well as the Millennium Development Goals indicators. UNdata is an aggregation of international and national databases providing open and free access to statistical information.
The Eurostat databases provides access to statistics and microdata on European economy and finance, industry and trade, environment and energy, population and social conditions, agriculture and fisheries, transportation, and science and technology.
CDC WONDER, or Wide-ranging OnLine Data for Epidemiologic Research, is an online database that provides free and open access to the information resources of the Centers for Disease Control and Prevention. WONDER resources include: CDC reports, recommendations and guidelines, articles, statistical research data, and public-use data sets. Data sets cover: deaths, cancer incidence, HIV and AIDS, TB, births, and census data
Business Dynamic Statistics is a series of openly accessible datasets provided by the U.S. Census Bureau that contain data on U.S. business dynamics. The featured data includes: economic data on employment, number of establishments, establishment openings and closing, number of startups and firm shutdowns as well as annual business and economic statistics.
UNEP Environmental Data Explorer is the online resource for data sets used by the United Nations Environment Programme and its partners. The online database holds national, subregional, regional and global statistics and geospatial data sets covering environmental related themes.
Business Insights is a database provided by Gale Cengage with access to company and industry information, articles, and statistical data. The data includes: case studies, coutnry profiles, statistics, market research reports, news articles, academic journals, and reference materials.
Immigrations, Migrations and Refugees: Global Perspectives, 1940-1996 provides access to firsthand reports and global analysis on human migration during the 20th Century. It includes: government documents and books, English-language radio and television broadcasts, newspapers, reports gathered by the Central Intelligence Agency, and more.
Content for this collection is primarily sourced from the Foreign Broadcast Information Service Daily Reports and the...
United Nations iLibrary is a platform that publishes the digital content created by the United Nations between 2013-2015, including journals and series on: international peace and security, human rights, economic and social development, climate change, international law, governance, public health, and statistics.
The database contains 750 titles in English, and 250 in other official languages of the United Nations: French, Spanish, Russian, Chinese, and Arabic.
In the future, the platform will also provide access to other resources such as working papers series and statistical databases.
While CRL makes every effort to verify statements made herein, the opinions expressed and evaluative information provided here represent the considered viewpoints of individual librarians and specialists at CRL and in the CRL community. They do not necessarily reflect the views of CRL management, its board, and/or its officers.

domain: library


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A place where writers go to make their visions come alive.
Free forum : Apocalyptic Roleplay
Come, meet magical creatures, befriend them or make foe, your choice!
A role play forum on Vampires, Lycanthropes, and other Magical Creatures,
Welcome to all mystical creatures! Who dares to walk among the humans? Or who hides in the forests and lakes of this site? We shall find out. Come and RP with us!
Britain and Germany are magical superpowers at war and the creatures are beginning an uprising. Join the Durmstrang Institute or Hogwarts School and fight for your cause.
A text based RPG based in the city of Calous, where the opening of the legendary Pandora's Box has caused the whole city to be over run by what can only be described as mythical creatures. Few are survivors, will you be one of them. ?
A Great text based role playing site that has many members everyday. We are looking for great creative members Join Today. The age of all types of creatures that roam the Earth and wage war against on
This is a world of hidden stories, powers, and people.
Shadow of Mystic Lands is a fantasy role-playing game site. With fantasy creature like werewolves, vampires, shape-shifters, as well as unique creatures.
An intermediate to advanced play-by-post roleplaying website set in the modern era where the world has been exposed to magical creatures, vampires play a part in human life, and the magical world has their own government.
A war is brewing between Creatures, Hunters, and Humans. Which side will you choose to fight on?
Free forum : This forum is about many things and you can freely post about them here !!
Free forum : Once all the kingdoms were on great terms with one another with only a few rocky tentions between a few. However with the tables turning will they last the test of time and mange to make
In the town in Lake Frost City supernatural creatures do exist and a huge war is brewing, who will survive and who will win?
Mythical Creatures Role Play.
Here lurks the most despiseable, alluring and conniving of all creatures. The Vampire. Damned to wander eternity forever in the shade of night, losing their humanity bit by bit. Welcome to your new home.
Free forum : All Creatures Welcome.
A Kingdom where fantasy creatures are welcome.
Free forum : Forum provided by the national exotic hedgehog rescue to promote the care and well being of all prickly creatures
Free forum : A whole area of supposedly Hidden Woods filled with lots of different creatures and ruins. Jump into a world of supernatural beings, confusing pasts, and danger. Loads of different ranks or types of things you can be. Please join today!
A school for the rich and powerful. Not to mention the creatures that hide behind it's walls. . .
Fate is a powerful thing in all creatures, deadly or not. It decides a great many things though we all try to ignore it. Here follows the path fate chose for three very different people.
Free forum : Heroes are born Heroes, Slayers are born Slayers. One possesses elemental powers, the other, arcane. Both are born due to the Gods' intervention. They are both protectors and destroyers o
Free forum : Placed in the depths of New York City. . lays a Wizarding School all purity, and creatures.
Free forum : In the Arctic many creatures thrive. but which will you be??
Free forum : Where Fantasy Meets Reality!
Miscrits Planet : The Fan Forums of Miscrits
Following the adventures of the heroes, villains, and creatures of Skyrim.

domain: entertainment


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Hyde Pierce won the 2007 Tony Award for his performance as a Boston cop addicted to musicals. Tony and Emmy Award winner Debra Monk, Tony Award winner Karen Ziemba, Jason Danieley, Edward Hibbert, John Bolton, Michael X. Martin, Michael McCormick, Noah Racey and Megan Sikora, will continue in the roles they created in Curtains.
Curtains, an original musical comedy about a murder backstage at Broadway-bound musical, has a book by Rupert Holmes (a Tony Award-winner for The Mystery of Edwin Drood) and songs by composer John Kander and lyricist Fred Ebb (the Tony Award-winning songwriters of Cabaret, Chicago, "New York New York"), with original book and concept by Tony Award-winner Peter Stone (1776, Titanic, The Will Rogers Follies). Additional lyrics are by John Kander & Rupert Holmes.
The 31-member cast also features Nili Bassman (Arlene Barucca), Bridget Berger (Roberta Wooster), Kevin Bernard (Roy Stetson/Detective O'Farrell), Ward Billeisen (Brick Hawvermale), Jennifer Dunne (Jan Setler), David Eggers (Swing), J. Austin Eyer (Swing), Jennifer Frankel (Marjorie Cook), Patty Goble (Jessica Cranshaw/Connie Subbotin), Lorin Lattaro (Swing), Shannon Lewis (Mona Page), David Loud (Sasha Iljinsky), Brittany Marcin (Peg Prentice), Jim Newman (Randy Dexter), Aaron Ramey (Harv Fremont), Joe Aaron Reid (Ronnie Driscoll), Christopher Spaulding (Russ Cochran), Jerome Vivona (Swing) and Stephanie Youell (Swing). For more information, visit www.CurtainsTheMusical.com.

domain: artistic


The National Park Service's Director’s Order 18 requires that all parks with vegetation capable of sustaining fire develop a Fire Management Plan. There are 1,170 acres of land within Hopewell Culture National Historical Park, which are burnable. The park's Fire Management Plan covers wildland fire suppression and prescribed fire activities.
Prescribed Fire at Hopewell Mound Group Unit - 2008
The park proposed and conducted a prescribed fire at the Hopewell Mound Group unit in Autumn 2008. The purpose of the six acre fire is to reduce the accumulation of hazardous fuels, suppress tree and shrub encroachment, and re-establish the dominance of native species. Click here to view the burn plan. The fire crew used All Terrain Vehicles (ATVs) during the burn to assist them in their duties. Policies regarding the use of ATVs in the park are established. Click here to view the park's ATV Plan and here to view the Standard Operating Procedures for ATVs.
More information and a map of the burn unit is available here.
To read more about the story of this prescribed fire event, click here.
Did You Know?
British soldiers captured during the Battle of Lake Erie during the War of 1812 were marched to a prisoner of war camp (Camp Bull) located between the present day Mound City Group visitor center, and the northern part of the city of Chillicothe. More...


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Major League Baseball franchise the Seattle Mariners has announced that T-Mobile Park will undergo $29.8m (£24.2m/€27.3m) in improvements and upgrades in time for the 2020 season.
The work will be carried out during the offseason and includes 49 basic infrastructure projects, as well as plans to enhance the fan experience across the 47,000-seat stadium.
The Mariners plan on spending at least $280m to maintain, improve and upgrade T-Mobile Park over the next 10 years alone. The Mariners’ 25-year lease agreement with the Washington State Major League Baseball Stadium Public Facilities District dictates that the team will have responsibility for the ballpark’s necessary improvements and upgrades.
Work will include the ongoing replacement of roof wheels, painting, plumbing and other basic infrastructure work; replacement of the 20-year-old sound system; replacement of the point-of-sale system and improvements for fans with disabilities. Infrastructure improvements will total $20.56m.
Fan upgrades will total $9.24m and include the expansion of Left Field Gate to include 15 additional points of entry, a new bar and fan/group entertainment space at Lookout Landing, an elevated Rooftop Boardwalk above the Home Plate Gate and a new seating option in the First Base Terrace Club.
The Lookout Landing will create a rooftop bar providing views of the stadium and the Seattle skyline. The Mariners said the space will have a “casual backyard experience” and feature bench seating and picnic tables.
The Rooftop Boardwalk will include a raised walkway for enhanced views of Puget Sound, along with bench seating and tables, outdoor LED video monitors, concession stands, a new bar area and kids-themed activities.
The Terrace Club will create a new seating concept through replacing a number of single seats in the First Base Club with 18 Terrace Club Tables that will accommodate four people each. Other elements of the project will include loge boxes with padded sofa-style seats, video monitors, mobile charging devices and in-seat wait staff service.
Mariners president and chief executive Kevin Mather said: “At 20 years of age, T-Mobile Park is still in good condition and a great place to watch baseball. The work we will be doing for next season and the years to come will ensure that it continues to be a first-class experience for fans and is our home for generations to come.”
Frances Traisman, senior vice-president of sales for the Mariners, added: “In many ways, T-Mobile Park was ahead of today’s trend toward social spaces with The T-Mobile ‘Pen. We know that fans want to connect with friends and share their ballpark experience. The improvements at Lookout Landing, the Rooftop Boardwalk and Terrace Club will provide fans with even more open areas and flexible spaces to enhance their ballpark experience.”
The stadium was previously known as Safeco Field but T-Mobile assumed naming rights at the start of 2019 as part of a 25-year deal. Safeco had sponsored the stadium for 20 years.


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11 December 2009
United Nations Secretary-General Ban Ki-moon:
"Far From Causing The Crisis, Migration is Part of The Long-Term Solution"
Message on International Migrants Day, 18 December 2009
VIENNA, 18 December (UN Information Service) - Migration touches upon every country, either as a place of origin, transit or destination, or as a combination of these. In 2009, an estimated 200 million people, or 3 per cent of the world's population, lived outside the country of their birth.
Migration can be a positive and empowering experience for migrants themselves, and for both the home and host societies. But for too many migrants, the reality is discrimination, exploitation and abuse. They are frequent targets of hate speech, harassment and violence. They are unfairly blamed for crime and economic difficulties, and are subjected to widespread discrimination.
The global economic and financial crisis has exacerbated the vulnerability of migrants. Many countries have tightened restrictions on migration, and adopted stronger measures to combat irregular migration. Such measures can increase the risk of exploitation and abuse. They may also reinforce the impression that migrants are partly to blame for the effects of the crisis, fuelling anti-immigrant and xenophobic attitudes.
Yet, even in places where unemployment is high, there is often a demand for foreign workers in particular sectors, where they provide the skills needed to propel economic growth. Far from causing the crisis, migration is in fact part of the long-term solution.
At the international level, The Convention on the Protection of the Rights of All Migrant Workers and Members of Their Families is a comprehensive framework for the protection of migrants' rights. I urge all Member States who have not yet ratified or acceded to the Convention to do so.
On this tenth International Migrants Day, I encourage Governments to protect the human rights of migrants, to put human rights at the heart of migration policy, and to raise awareness of the positive contributions migrants make to the economic, social and cultural lives of their host countries.
* *** *


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Barbara’s son Jake is a medically complex young adult living at home with his parents. Jake relies on Medicaid to provide the services he needs to be medically safe and supported at home, including continuous skilled nursing and personal care assistance (PCA).
To be eligible for these services, Jake undergoes an annual assessment. This determines the number of support hours that are medically necessary for him to live safely at home and not in an institutional setting. Living in the comfort of his own home—and getting his medical, social, emotional, and recreational needs met, surrounded by loved ones—is important to Jake and a top priority for his family.
When Jake receives the support he requires, it is also of significant benefit to the state, since providing support for medically complex individuals at home is far less costly than residential or institutional placements. When the system works as it is intended to, everyone wins.
Currently, Jake is authorized to receive over 50 hours of continuous skilled nursing and over 70 hours of PCA services per week. The problem is there is a significant shortage of home-based nurses and caregivers for individuals like Jake, so only a small percentage of his authorized hours are staffed.
For several years, less than 10% of Jake’s nursing hours and less than half of his PCA hours have been filled. It is not uncommon for Jake’s parents to go days or weeks without help.
So, what happens when families can’t find appropriately trained staff and states can’t meet the mandate of filling authorized hours with reasonable promptness?
For Jake’s parents and for other families caring for medically complex pediatric and adult children living at home, it means the burden of care typically defaults to family members, putting an immense strain on families.
For Barbara and her son, the toll is significant. In Barbara’s words:
“I am Jake’s mother and guardian but, by necessity, I am also a full-time caregiver, routinely performing the duties of a nurse, personal care assistant, and home health aide. Having my son at home is not a burden, but providing the care he needs without the help that he is due is taxing at best and unsustainable and dangerous at worst.
I am typically ‘on duty’ 24/7, providing clinical care without any qualification or expertise other than lived experience. The relentless task of providing full-time care results in chronic sleep deprivation, exhaustion, and isolation. There are no days off. If I am not directly providing care, I am managing the endless list of duties that support our fragile infrastructure: recruiting help, managing prescriptions, ordering medical equipment and supplies, making and attending medical appointments, ensuring assessments and care plans are up to date, and working with multiple agencies and providers.
The low rate of pay offered to nurses and other homecare providers offers little incentive to pursue these jobs and is not competitive with less-taxing, higher-paying positions. Not being able to offer attractive, competitive pay commensurate with the expected level of skilled care that needs to be provided forces families to hire less qualified help out of desperation. This puts the lives of our children at risk. We should not be forced to lower the bar at our loved one’s expense.
Not having skilled care providers in our home means more frequent and costly ambulance calls, emergency room visits, and hospitalizations. It also means that parents routinely need to make critical, ‘in the moment’, medical decisions without direct guidance or support from trained clinicians who know their child well. Making the wrong decision could mean the difference between life and death. Imagine, living with the burden of that responsibility. [Jake’s] life is in my hands, every single day.”
The occurrence of a global pandemic exacerbated a chronic nursing shortage. It also shed a greater spotlight on the unique challenges faced by parents who care for medically fragile children at home. While the pandemic has wound down for many, for families like Barbara’s, the parameters under which it forced us all to live will continue. The challenges she faces of keeping her son safe, home, and alive remain a daily struggle, and the shortage of qualified caregivers persists. These families are in crisis, and they need help.
Barbara hopes that sharing her story will encourage other families to do the same. “Advocacy starts with creating awareness. Through telling our stories, we find and build community. Through community, we build strength and increase the power of our advocacy. At all levels, we are facing a crisis and our voices need to be heard and acknowledged. As a country, we can and must do better. Our children’s lives depend on it.”
The post Barbara Advocates for Her Son Jake Because His Life Depends on It appeared first on The Arc.

domain: health


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text:
You either live in Southern California or Western Washington, and both are amazing places to have an opportunity to spend some or all of your life. Here in Southern California, where I spend most of my time, we’re blessed with 330 days a year of sunshine. We’ve got beautiful beaches and there’s always something going on somewhere. Almost anywhere you turn, someone’s doing something crazy and interesting.
Washington State doesn’t have the weather, but it’s got scenery and wonderful people. And even if it’s not as sunny as SoCal, it’s hardly ever too cold to just take a walk with someone you care about (or even your dog) and just indulge in the fresh air.
And last I checked, all that stuff was free. You don’t need me to remind you that the best things in life will always be free.
My name is Michael Rice. I have a unique, small practice limited to personally representing a small number of bankruptcy and litigation clients each month who are looking for creative and direct ways to deal with debt. My practice is to look for any option other than bankruptcy first: sometimes I’m able to resolve a short-term lawsuit or sometimes I’m able to help you negotiate with a difficult creditor. Sometimes I can do this for a low flat fee of $500.
But if it looks like bankruptcy is the best option for you, then I structure to case to maximize your discharge and the best way to time your case. While you can learn a lot about bankruptcy online, these aspects are part of the art of bankruptcy that takes years to master.
In all cases, I spend a lot of time working with clients one on one. I love working with clients directly, so I don’t use any paralegals or staff.
Please just send me an email to firstname.lastname@example.org or call me at 888-912-1922. I’m easiest to reach nights and weekends.
I am licensed in both Washington State and California. I graduated magna cum laude in the top five percent of my law school class from Seattle University School of Law in 2009 where I was on the Editorial Board of the Law Review and Dean’s List member. After law school, I was the judicial clerk to a federal bankruptcy judge for two years.
I’m admitted to practice before all state courts in California and Washington as well as the federal courts in the Western District of Washington and the Central District of California.
Before all that, however, I lived (and continue to live) in the real world. I worked in “Corporate America” for over a decade before going to law school. I know first hand what it’s like to live through layoffs, raise kids, and try to pay a mortgage — the “full catastrophe!”

domain: law


text:
plant will operate for 9 more months
Labs to initiate second round of layoffs
The second round of layoffs at Vernay Laboratories will take place next
week, according to company officials, who recently notified remaining
workers of specific layoff dates for the upcoming year.
The company has also revised its schedule and will close its largest plant
next September, nine months later than the original plan. The smaller
plant will remain open for the foreseeable future.
Company officials had originally said that Plant 3, the largest facility,
would close by the end of the year and that the smaller Plant 2 would
remain open until mid-2003.
The plant closings have been pushed back due to concern for production
quality, Plant Manager Mike Maloy said in an interview Tuesday.
We want to make sure our customers dont feel the effect of
an ill-timed move, Maloy said. Company officials are very
confident that the layoff dates will proceed as scheduled in the
revised plan, he said. As we proceed well monitor our progress
and if we need to make adjustments, we will, he said.
The company announced the layoff schedule to enable production workers
to make plans, said Maloy.
Vernay union representative Ralph Foster said workers have felt frustrated
with company management due to a lack of specific information about the
exact dates of layoffs.
We do realize peoples lives are affected and were trying
to be open with information, Maloy said.
The company announced in June that it would close its two Dayton Street
plants and transfer production facilities currently located there to the
companys plants in Georgia and South Carolina. Company officials
decided to close the plants for several reasons, including a shifting
customer base, outmoded production techniques at the local plants and
costs associated with an upcoming environmental cleanup.
The companys headquarters and research and development division,
which employ about 50 people and are located on South College Street,
will continue to be located in Yellow Springs for the foreseeable future,
Vernay officials have said.
Next Friday, Dec. 20, 15 production workers will be let go in the companys
second round of layoffs, according to Foster. The employees, who are all
hourly production workers, are the lowest in seniority, ranging from 7-
to 10-year employees. The layoff announcement came at the end of November,
The first layoff, which involved 25 production employees with the lowest
seniority, took place in October.
Currently, the plants employ 124 workers, Foster said. Between 25 and
30 employees have left the company since the June announcement to take
early employment, he said.
According to the companys revised schedule, 15 more workers will
be laid off on Jan. 17, 30 on Feb. 28, 15 on June 6 and 15 on Sept. 12,
at which point Plant 3 will close. The 35 workers remaining will work
in Plant 2, said Foster. Those workers may not necessarily be people who
currently work in Plant 2, but will be the employees with the most seniority,
he said. They will be retrained to handle Plant 2 work, he said.
Currently, company officials have no specific plans as to when Plant 2
will close, said Maloy.
There are no plans beyond continuous operation for Plant 2,
said Maloy. He added that the lack of plans for a closing doesnt
necessarily indicate that the plant will stay open, but that company officials
have been focusing on closing down Plant 3 instead.
Once we complete the shutdown of Plant 3 well re-evaluate
closing Plant 2, he said.
Although plant workers have known for months that they will lose their
jobs, finding out the specific lay-off dates has been difficult, said
You can hear about it all you want, but when you see your name on
the board, its a shock, he said.
The company held two meetings this fall during which state and county
officials discussed unemployment benefits and job training options, said
Foster. Workers may collect 26 weeks of unemployment benefits, which amounts
to half a workers regular pay, with the possibility of a 13-week
extension, said Foster. Employees also have the option to continue receiving
insurance coverage for six months, with partial co-pay.

domain: economics


text:
Wedding Invitations + signs
It’s exhausting to scour the web trying to find a design that might, kind of, sort of fit with your theme. And then you still have to “customize” it. It’s overwhelming! That’s where I come in. I relieve the overwhelm. Which, as a fellow new bride myself, I totally understand can build up real quick.
I have over 10 years of experience in graphic design. I love everything about it! That means I have the experience and passion to make your invitations beautiful and professional.
Your wedding isn’t cookie-cutter, neither should your wedding invitations be. I get to know you as a couple and I learn all I can about the style and theme of your wedding.
Sets start at $300
Ready to find out more?
Get in touch and let's make it happen!


text:
There is a huge selection of lodging certain to match all your needs and preferences. Because it is very much a kid-focused destination, numerous hotels in Orlando, Florida, present family-friendly features such as pools, game rooms, and entertainment. However, various accommodations also cater to solo vacationers, couples, and business travelers, who prefer a calm and quiet oasis away from the theme park frenzy.
Driving is one of the quickest ways of getting around Orlando, especially for those planning to visit sites other than the amusement parks. Book a rental car in Orlando to travel on your own terms.
Other forms of transportation include the Lynx, I-Ride Trolley, and the Lymmo Bus. Orlando’s public bus service, Lynx, provides service to many of the parks. The I-Ride Trolley is a bus that services the stops along International Drive. Orlando also provides the free Lymmo Bus that circuits City Hall to Centroplex downtown. You can also use taxi services for late-night or direct transportation.
Without a doubt, theme parks are one of the main attractions in Orlando. For vacationers wanting to explore these attractions, purchase tickets ahead of time and make a game plan. Also remember these parks are vast, brimming with rides and attractions, which makes it seemingly impossible to see every nook and cranky. Before arriving, make a list of all the must-see attractions to ensure you experience your favorite parts.
A comfy pair of shoes is the key to surviving the theme parks. Guests have clocked in anywhere between 10 to 14 miles of walking each day at areas such as the Epcot® Theme Park; you, too, will feel the burn! When you only have a few days to hang with Mickey and his gang, don’t cut your day short because of achy feet. Dress comfy so you can keep up with the kids.
Orlando features a subtropical climate, making it an ideal destination to visit any time of the year. The winter season is the dry season, and it’s common for temperatures to settle in the comfortable 70s and 80 degrees Fahrenheit during the day and drop down to the 50s and 60s F in the evenings. The summer months bring muggy temperatures, heat, and rain. During these months, temperatures hover around the 80 degrees Fahrenheit range, sometimes even hitting the 90s F.
Even though summer is technically the wet season, it’s not uncommon for a rain shower to roll through in the afternoon at any time of the year. Though these storms don’t usually last long, pack an umbrella so you can stay dry. Also realize, late summer is prime time for hurricanes to hit with September being especially prone to tropical storms. If a big storm hits during your stay, follow the warnings and proper procedures to stay safe and dry.
Whether you visit Orlando during the height of the summer or during the holiday celebrations in the winter, you’re certain to have a memorable Orlando vacation. Allow us here at Expedia.com to find you cheap Orlando hotel deals to get your getaway started today.

domain: travel


text:
This morning, I woke from a pretty good night's sleep and felt like I was doing much better, but as the morning progressed, the ickiness kinda crept back in and by mid-morning, I was feeling thoroughly cruddy again. So, I took another day off work, took Norah to daycare this afternoon and then slept for about 2 hours.
The sleep seems to have helped, and I just ate, and that too seems to be helping. But I'm only cautiously optimistic right now.
Man, being sick stinks.

domain: medical


text:
433813.M41 – 06h00-18h21
After a two week preliminary bombardment that saw a number of renegade defences destroyed, 2nd Company launched the first wave assault. Supported by a squadron of Leman Russ from the 11th Assault Korps their objective was to seize the trenches at Sector 33-12 and force a breakthrough of the outer defence lines.
The progress was initially slow, with the company’s right flank collapsing under heavy mortar fire, but the pressure of the Krieg Leman Russ forced the renegades to call up reserve units to blunt the attack.
Lieutenant Harbrov’s 3rd Platoon had made good progress on the right flank thanks to mortar fire pinning the renegades in their trenches. After a brutal hand to hand combat, he had secured the front trenches. However this success was fleeting as a hulking pack of Ogryns charged through the fog. They barreled through the whole of the 3rd Platoon, butchering everything in their sight. Despite Lieutenant Harbrov’s heroics in slaying one of the beasts, he was pulverised by an improvised weapon built from a power drill.
Eventually 10th Platoon’s autocannon squads were able to slay the monstrosities thanks to sheer weight of fire.
Renegade armoured support proved ineffective against the Leman Russ of 11th Assault Korps. Despite landing several hits, the traitor Vanquisher was unable to knock out a single tank and was forced to withdraw after counter-fire destroyed the tank’s turret.
The second and third waves were sent in, sensing that a breakthrough was possible. However, 2nd Company was ultimately unable to clear the trenches of all enemy forces and as such was forced to pull back to the Krieg lines.
Objective: Not secured
Krieg casualties: 75% [level acceptable]
Report compiled by Munitorum adept Fyget, assigned to the 88th Siege Army Staff Headquarters, Thracian Primaris
Tom and I had great fun playing a Siege of Vraks game – we’ve been meaning to do it for ages and finally finished up painting enough terrain to do it justice. We each built a 1,250 point list using the Siege of Vraks second edition for this game.
We played a mission from the 4th edition rulebook (which was the edition that the first Siege of Vraks book was written for). The attacker had to wipe out the defender completely to win the game, all the defender had to do was survive (which I did with one man left!)
It was an interesting game, with Tom having a preliminary bombardment that cleared some key defences and his destroyed troop choices coming back via ongoing reserves.
Still, it felt like a bit of an uphill struggle for the attacker, so we may tweak the mission a bit. Then again, trying to storm a trench isn’t an easy task – just ask the 88th Siege Army!

domain: history


Fair Use Put to Good Use: 'Documentary Filmmakers' Statement' Makes Decisive Impact
In the nearly two years since IDA with other film organizations launched the Documentary Filmmakers' Statement of Best Practices in Fair Use, the rapidity of its adoption has been almost startling.
"I never anticipated, frankly, that the Statement would have such an immediate effect," says Professor Peter Jaszi, one of the facilitators of the creation of the statement and the lead legal counsel behind it.
The Statement clarifies when it is safe for a filmmaker to assert fair use, which is the unauthorized use of copyrighted material under certain circumstances. The clarification makes it possible for filmmakers to dramatically lower clearance costs while also honoring copyright ownership.
"Success has many mothers," says Michael Donaldson, past president of IDA and a member of the project's legal advisory board. "You can now see many organizations building it into their process, and starting their own projects depending on it." He pointed, among other things, to Stanford University's Fair Use Project (http://cyberlaw.stanford.edu/node/3136), which defends filmmakers so long as their fair uses accord with the Statement.
Most important, from a filmmaker's perspective, it is gradually becoming normal for gatekeepers to accept filmmakers' fair use claims, when backed by the principles and limitations articulated in the Statement. Some highlights include:
- release of films that could never have been seen publicly, or possibly even finished, such as Hip Hop: Beyond Beats and Rhymes (Sundance, PBS/ITVS Independent Lens), This Film Is Not Yet Rated (IFC Films and IFC cable channel), The Trials of Darryl Hunt (HBO);
- savings of millions of dollars in unnecessary licensing costs by using the Statement as a tool in negotiations ($400,000 in one film alone, IFC's Wanderlust);
- adoption into business practice in public television, e.g.
- Independent Television Service (ITVS) endorses it;
- WGBH producers give it out to their producers, and use it;
- Public Broadcasting Service (PBS) has shared it with all general counsels and general managers in its network;
- PBS and ITVS jointly used it to clear Hip Hop: Beyond Beats and Rhymes for broadcast;
- adoption of the Statement into business practice by cablecaster IFC, and for case-by-case use in other cable companies, including HBO, Discovery Times and the Sundance Channel;
- acceptance by the four major US insurance companies for errors and omissions insurance of fair use claims (AIG, MediaPro, ChubbPro and OneBeacon);
- publicizing of the Statement among lawyers by The Copyright Society of the U.S.A., the leading association of copyright attorneys, which has showcased fair use and the Statement at regional and national meetings;
- posting of the Statement on the Revver.com website's guidelines, extending this knowledge to online video posters;
- endorsing and publicizing of the Statement by the University Film and Video Association, the leading association of film and video teachers in higher education.
Errors and omissions insurance may well be the best gauge of the adoption of fair use in general, and the Statement in particular, since insurance companies are both the ultimate gatekeepers for television documentary and also historically cautious to adopt practices that involve risk. And since fair use is a right that can be challenged as well as asserted, insurance companies have typically only accepted fair use claims with considerable negotiation, on a case by case basis, and have much more routinely insisted that rights be licensed.
The four companies most used by US documentary filmmakers--AIG, MediaPro, ChubbPro and OneBeacon--all announced programs between January and May 2007 to cover fair use claims. They first became aware of this issue for documentary filmmakers through meetings in Fall 2006, coordinated by American University law professor Peter Jaszi, P.O.V. executive director Simon Kilmurry and insurance broker Debra Kozee. Soon after, Kozee tested the waters with Byron Hurt's Beyond Beats and Rhymes, which has extensive quotation from hip hop video and music. She found several insurance companies newly interested, with all requiring a legal letter of opinion about fair use. The Statement made such a letter of opinion far easier to write than ever before. Jaszi complied, and Hurt's film was insured by AIG.
"I think AIG was more aware earlier of the value of the Statement because of New York geography," Kozee recalls. "I bumped into their rep all the time because our offices were around the corner from each other."
AIG quietly began offering coverage based on the precedent set by Hurt's film. MediaPro was the first to make public its acceptance of fair use claims, at the IDA's 25th Annual Celebration of Academy Award Nominees in February 2007. Soon ChubbPro also announced its willingness to insure fair use claims with proper opinion letters, and OneBeacon followed in April.
MediaPro made a special arrangement with Hollywood attorneys and with the Stanford University's Fair Use Project. If the Fair Use Project agrees to defend a filmmaker pro bono in case of lawsuit, or if several Hollywood attorneys including Michael Donaldson agree to defend the filmmaker for reduced fees--both decisions dependent on the filmmaker complying with the terms of the Statement--MediaPro agrees to pay legal costs if the defense fails. MediaPro also requires a complete shot list.
Other companies follow AIG in simply requiring a legal letter of opinion. ChubbPro offers IDA members a discount, although the nature of the discount depends on individual negotiation. ChubbPro's Ken Goldstein, worldwide media liability manager for Chubb Specialty Insurance, noted that in the past ChubbPro had been willing, in principle, to consider insuring a fair use claim, but since the Statement's release, he is willing to make that explicit. "In light of recent developments in the industry," he notes, "we have added a fair use endorsement to our media product library."
Insurers do not have standard pricing. Insurance policies are each negotiated individually, and filmmakers sometimes try several companies to find out which offers the best arrangement.
"I'm really pleased that documentary filmmakers now have this insurance option," says Kozee. "It's still important for filmmakers to recognize that getting the best insurance policy still requires negotiation."
The Documentary Filmmakers' Statement of Best Practices in Fair Use has had a profound effect on the documentary marketplace, still shy of its two-year mark. It will continue to make possible more and better documentary work, all without jeopardizing the strength of copyright ownership, if filmmakers continue to use it and tell others about its effectiveness.
Pat Aufderheide is the director of the Center for Social Media.


Two of the strongest teams in the EU LCS are set to face off against each other on July 22 for the first time this Summer Split.
Fnatic and Unicorns of Love of Love both come out of a disappointing Rift Rivals, where both came up short to North American sides. With Summer Playoffs on the horizon, both teams are now looking to show why they should represent the EU LCS at Worlds 2017 in China.
When the Summer Split began, Unicorns were one of the favorites to challenge for G2 Esports’ title. The team had challenged G2 on every front in Spring Split and finished in second place. Fnatic, on the other hand, had just formed a new team and managed to finish at a respectable third place in the Spring Split, beating Misfits in the third-placed match up.
Things have changed since then.
Fnatic announced itself in the Summer Split as one of the top teams in Europe, topping Group A over the likes of Misfits and G2 Esports. Unicorns, on the other hand, registered their first ever series with against G2 Esports, ever, and are looking for their first EU LCS title at the end of the season.
Fnatic and Unicorns never go along with the meta and pick up champions that their opponents can’t prepare for. Kennen AD and Hecarim jungle are just two of the picks that both teams have chosen throughout the season that have led to a series win.
The matchup to look out for will be Rasmus “Caps” Winther of Fnatic and Fabian “Exileh” Schubert of Unicorns, two of the best mid laners currently in the EU LCS. Both these players have had indifferent seasons, but their teams will be hoping to see an upturn in form during this crucial matchup.
Both players are playmakers and thrive in team fights during the big moments. Both teams will be looking to get their mid laners ahead to have a greater impact as the game goes on. If either player falls behind in the early game, it could spell disaster for the team as a whole.
Both teams have similar chaotic play styles that can disrupt the meta but when both teams are playing with the same mindset—anything is possible. Whatever the result, this match could go a long way to determining the outcome of the Summer Split.


text:
My African roots made me what I am today. They're the reason I exist at all.
Many people do not realize that where unions have bargaining rights employers cannot raise wages or improve benefit plans any more than they can reduce them without of the consent of the union.
When someone is anonymous, it opens the door to all kinds of antisocial behavior, as seen by the Ku Klux Klan.
For un-subscribe please check the mail footer.

domain: sociology


text:
OTTAWA–Manufacturing sales rose 5.5 per cent in July to $41.4 billion, adding to the 2.2 per cent increase reported in June, Statistics Canada reports.
The agency said Wednesday the July jump came with improved performances in the motor vehicle, motor vehicle parts and primary metals industries.
Production in the motor vehicle industry rose 48.2 per cent in July to $3.3 billion, as some assembly lines resumed production following extended shutdowns.
Sales in the auto parts industry increased 30 per cent to $1.5 billion in July, reflecting higher demand from assembly plants.
However, overall July manufacturing sales were still 22.4 per cent below the $53.3 billion recorded a year earlier.
Excluding the motor vehicle assembly and parts industries, manufacturing sales increased 2.1 per cent.
Sales in 15 of 21 manufacturing industries increased in July, representing 66 per cent of total sales.
While the auto sector improved in July, vehicle sales were lower than levels seen over the past few years. July car and truck sales were down 22.6 per cent from the same period a year ago.
Sales in the primary metals industry rose 11.2 per cent in July to $2.7 billion.
Aerospace products and parts rose 12.2 per cent and plastics and rubber products were up 9.0 per cent.
The largest declines came in sales of petroleum and coal products (off 3.6 per cent) and food (down 1.3 per cent).
Lower prices were blamed for the drop in petroleum and coal products.
Ontario showed an 11.9 per cent increase in sales in July as its auto plants rebounded.
Excluding motor vehicles and parts, Ontario's manufacturing sales rose 4.1 per cent. The province also benefited from a 34.2 per cent rise in sales of primary metals.
In Quebec, sales increased 4.0 per cent, adding to a 6.0 per cent rise in June. The advance was broadly based as higher sales were seen in 17 of 21 industries. Aerospace firms posted the largest increase in production in dollar terms, rising 6.4 per cent.
Sales fell by 4.0 per cent in Alberta in July, largely because of a 10.7 per cent drop in food sales. Lower petroleum and coal product sales also contributed to the decline.
Manitoba, Saskatchewan, Newfoundland and Labrador, Nova Scotia and British Columbia all recorded declines in sales.
Manufacturers reported a 2.0 per cent drop in inventories compared with June. Inventories have been decreasing all year.
The backlog of unfilled orders fell 4.3 per cent in July to $57.1 billion, largely due to a 6.4 per cent decline in the aerospace industry.
New orders fell 3.7 per cent in July to $38.8 billion. The decline was concentrated in the aerospace industry.


text:
Ahmed was known in his circle in Mali for his defiance. He challenged militant Islam and Islamic doctrines with a Facebook page named Atheism. The Facebook page took on controversial issues relating to Islam, terrorism, and it championed freethought.
Mali is a stronghold of Islamic terrorist outfits such as ISIS and Al-Qaeda. Criticizing Islam there is likely to mean death. Ahmed’s activism made him a prime target of Islamic extremist outfits. And many zealot clerics have taken a special interest in him because of his activism and lack of belief in Allah. Eventually, he had no option but to flee war-torn Mali. He sought safety in the Republic of Niger in West Africa.
In May 2021, along with a friend, he visited a refugee camp in the Niger Republic with the hope of being admitted and registered as a refugee but was told that the facility was full. They were advised to go to another refugee camp in Niamey, the capital of the Niger Republic.
On the 25th of May 2021, Ahmed and his friend left for Niamey heading for the office of the High commissioner of refugees but whilst on their way, the police were alerted and Ahmed and his friend were tracked down and arrested on a vague charge of ‘association with terrorism’. It is worth mentioning that in many countries activists who criticize Islam face such persecution—instead of protecting people like Ahmed, the authorities instead act as oppressors.
Ahmed reached out to Atheist Alliance Alliance International for help after spending nearly eight months in one of Africa’s most inhumane prisons.
We promptly appointed a high-profile lawyer in Mali and asked our supporters for help. The response was overwhelming. We sincerely thank our donors and supporters for their generosity.
On June 01, 2022, Ahmed was freed by the court because the state could not prove any of the charges of terrorism made against him.
“Hello! I’m very happy to tell you that I am free tonight and today I thank you very much, a deep and sincere thanks for you have given me a help beyond one’s imagination”, Ahmed told us after the court decision. We’re proud to help persecuted atheists and those battling blasphemy charges across the globe.
Atheist Alliance International is fighting several blasphemy cases right now. The victims of these Blasphemy lawsuits include authors, bloggers, content creators, and musicians. To help us support the victims of blasphemy laws, please donate to our Blasphemy Legal Aid Fund.


Once again, it’s that bittersweet time of year when the 2005 Rochester International Jazz Festival is winding down. Most of the bands have played. Most of the jams have happened. And while there are still some outstanding shows on the way, your thoughts can’t help but turn to the realization that in three days most of Rochester will forget about jazz for 51 weeks.
I worked the door at the Montage Grille again last night. The Moutin Reunion Quartet blazed away inside, one of the hottest acts of the festival. People left raving about the band after the first set, and the word quickly spread, with people coming in as much as two hours before the second set to make sure they got a seat. I heard that the band will be back in Rochester in the fall — don’t miss them. They’ve also got a new record coming out in August, the follow-up to their excellent album Red Moon.
I spent a lot of time last night chatting with some of my favorite jazz people in town. In addition to Erik Telford (whose Miles Radio blog is worth your time), I talked with Gerry Youngman and Jared Schonig of Paradigm Shift. If you’ve never checked them out, do yourself a favor and catch them. You can find out more about the band here, and you can read a review I wrote of their album Shifting Times. If you’ve read the program for the Rochester International Jazz Festival, then you’ve already read most of the review, because it was copied — without attribution — in the program. What’s that Tom Lehrer tune?
UPDATE: Turns out the program notes are provided by the artists, so the festival is not at fault. And of course the Paradigm Shift guys are friends of mine, and I’m sure they meant no harm. But it is important to remember that published work should be credited.


Sekonic L-758DR Flash Meter Features:
What moves the L-758DR DigitalMaster to the head of the class? It's the only meter that can be calibrated to read light the way your particular camera system reads light.
Every camera system is unique. Optical, mechanical and imaging components all act on each other to produce slight differences in exposure and the dynamic range of the camera system. Sekonic helps you discover the differences in your camera system and use this information to control light, make better exposures and take better pictures than ever before.
By running an easy calibration test using Sekonic's L-758DR, one of Sekonic's Exposure Profile Targets (purchased separately) and the available DTS V3.0 Software (Mac & Windows), you can accurately profile the characteristics of your camera's imaging system to determine its true native ISO, dynamic range and clipping points.
After processing the test data and determining exposure parameters, the resulting data is uploaded from your computer via the included USB cable to the meter, where it is stored as camera profiles. Profiling data from up to three cameras can be stored in your meter for instant recall.
Knowing the dynamic range of your digital camera can help you get the best exposures possible. Using the Sekonic L-758DR Light Meter and Sekonic Exposure Target plus Free Data Transfer Software, you can profile your digital camera and lens combinations. The result is total exposure accuracy.
Reflected Light Spot Metering
The Sekonic L-758DR incorporates a precise 1-degree, reflected light spot meter. Reflected light metering tells you about the subject. Different from incident light metering that produces readings only for the middle of your camera's exposure range, reflected light metering can also show you where the edges are. The key to working with the L-758DR's spot meter is knowing the dynamic range of your camera. That is, the tonal range your camera is capable of recording. Program this into the L-758DR and you can easily know which details will be properly imaged and which will be over or under the range of your camera.
Incident Light Metering
Incident light readings are, in fact, the simplest and most direct way to determine exposure. And because incident meters measure the light that falls on your subject, they provide camera settings that render the image exactly the way it appears. Blacks are black. Grays are gray. Whites are white.
Retracting the Sekonic L-758's Lumisphere enables you to quickly judge the brightness of multiple light sources for fast, accurate adjustment of lighting ratios.
Digital Photography: Boundless Possibilities
Today's High Dynamic Range (HDR) processing enables breaking through the limits to produce results never seen before. Knowing your camera's capabilities and precise exposure readings with the L-758D will help you make right exposure settings and save you time in processing. The picture of this Mexican plaza and church was created shooting multiple images (below) and merging them in HDR processing to create the image on the right.
Determining Dynamic Range with Exposure Profile Targets (separate purchase)
Shoot with the equipment you use most. Make tests under daylight and studio lighting. Exposure Profile Target requires an 11-shot bracket (0, +/- 5EV). Exposure Profile Target II requires a 3-shot bracket (-3EV, 0,+3EV). Make a spot reading of 18% reflectance tone and incident reading in front of target and record data. Shoot the bracketed shots based on incident light measurement. The Sekonic Exposure Profile Targets and Xrite ColorChecker targets are available as a separate purchase from your local reseller.
Download test images into computer. If shot in RAW, convert to TIFF or JPEG for computation. Enter ISO, incident, and reflected light shooting data. Then select and align images for processing and press OK to watch the Sekonic Data Transfer Software program graph the dynamic range of your DSLR camera. Save the data for transfer to the L-758DR.
Switch OFF L-758DR. Connect it to the computer with USB cable and switch L-758DR ON. Select up to three camera profiles. Press transfer. Switch OFF L-758DR, disconnect, and switch ON to begin using.
Full information Spot Viewfinder
The 1-degree spot meter has a broad reading range from EV 1 to EV 24.4 for ambient light and measures flash down to an amazing f/2.0. Its large, bright viewfinder with diopter correction and full-information data display give you everything you need to make the right exposure decisions without having to take your eye from the eyepiece.
Memory Mode and Latitude Display
Up to nine readings can be memorized and displayed on the meter's analog display. Once programmed, the L-758DR's latitude display mirrors the dynamic range of your camera and is your guide to making exposure decisions that will get you the pictures you want.
Use the L-758DR's contrast function to simplify measuring the brightness range of a scene. Spot meter a mid tone or take an incident-light reading and press the AVE/V button to create a mid tone standard. Then press the measuring button to display the brightness difference between the standard and new reading. Knowing the dynamic range of your DSLR is vital to making the best use of this important feature.
Ambient Light Metering
Take shutter-priority or aperture-priority readings from 30 minutes up to 1/8000 second and f/0.5 to f/128 and display them in full, 1/2 or 1/3 stop increments. Exposure is displayed both digitally and on an analog scale for easy readout. Settings can be changed after reading with automatic calculation to maintain the proper exposure. The extended sensitivity range, EV -2 to 22.9 (Inc) and EV 1 to 24.4 (Ref) for ISO 100, enables taking measurements over a wide range of lighting conditions.
Flash Light Metering
Shutter-priority readings of flash light can be made with a synch cord or cordlessly at shutter speeds from 30 minutes to 1/1000. The L-758DR automatically resets after each reading in cordless mode, to enable fast adjustment of flash brightness.
Built-in Radio Flash Triggering
Simply press the measuring button to wirelessly trigger flash units up to 100 feet away. The built-in transmitter offers 32 digital coded channels and Quad-Triggering Zones and is compatible with PocketWizard radio triggering systems (except ControlTL), as well as the PocketWizard Wireless Freedom partners. Learn more about Radio Triggering.
Flash Analyzing Function
The L-758DR is especially useful for on-location shooting to lighten shadows or reduce background detail. That's because it measures ambient and flash simultaneously and automatically indicates the percentage of flash in the total exposure. You can easily adjust the ambient flash mix by turning the Jog Wheel. The digital display indicates the camera settings and an analog display shows the relationship between ambient and flash and the total exposure.
Enables instant adjustment or exposure readings for different ISO, filter factors, exposure factors, or exposure biasing.
Turn to position incident dome properly while maintaining full view of the data display.
Illuminated Data Panel
Comes on at levels below EV 6.
Dust-proof and splash-proof (JIS Standard Water Resistance Class 4).
14 custom settings enable setting the display for full, 1/2 and 1/3 stop readout, adjust Latitude display, control functions, select displayed exposure modes and more.
Sekonic L-758DR Flash Meter Specifications:
- Type: Digital exposure meter for ambient and flash light
Rotating Domed Head 90° to the right, 180° to the left, Retractable for Contrast Reading
- Light Receiving Method: Incident light and reflected light
- Receptor Incident Light: Convertible to flat diffuser (Lumisphere in down position)
- Receptor Reflected Light: 1° spot with display in finder
- Light Receptor Element: 2-Silicon photo diodes (incident and reflected)
- Reflected Metering Distance: 3.3' to infinity/1.0m to infinity
Measuring Modes Ambient Light:
Aperture priority metering
Shutter priority metering
Measuring Modes Flash:
Measurement using the included wireless flash radio triggering system (cumulative and non-cumulative)
Without synchro cord (cumulative and non-cumulative)
With synchro cord (cumulative and non-cumulative)
Measuring Range (ISO 100) Ambient Light:
Incident light: EV -2 to EV 22.9
Reflected Light EV 1 to EV 24.4
Measuring Range (ISO 100) Flash:
Incident Light f/0.5 to f/161.2
Reflected Light f/2.0 to f/161.2
- Repeatability Repeat Accuracy: (+/-) 0.1 EV or less
- Calibration Constant Incident: Lumisphere C = 340, Lumidisc C = 250
- Calibration Constant Reflected: K = 12.5
- Display Range Film Speed: ISO 3 to 8000 (in 1/3 steps)
Display Range Shutter Speeds Ambient:
30 min to 1/8000 sec. (in 1, 1/2, 1/3 steps) plus 1/200, 1/400
Display Range Shutter Speeds Flash:
30 min to 1/1000 sec. (in 1, 1/2, 1/3 steps) plus 1/75, 1/80, 1/90, 1/100, 1/200, 1/400
- Display Range Aperture: f/0.5 to f/161.2 (in 1, 1/2, 1/3 steps)
- Display Range EV: EV -9.9 to EV 46.6 (in 1/10 steps)
Display Cine Speeds fps:
2, 3, 4, 6, 8, 12, 16, 18, 24, 25, 30, 32, 36, 40, 48, 50, 60, 64, 72, 96, 120, 128, 150, 200, 240, 256, 300, 360 (shutter angle: 180°)
Display Range Analog Scale Aperture:
f/0.7 to f/90 (in 1, 1/3 steps)
- Display Range Analog Scale EV: EV -7 to EV 7 (in 1/3 steps)
- Exposure Out Of Range: Eu (underexposure) or Eo (overexposure)
- Memory Function: 9 readings
- Average Function: Up to 9 readings can be averaged
- Flash Analyzing Function: 0 to 100 percent in 10 percent increments
Multiple Flash Function:
Infinite number of flash readings (Only one digit is displayed when the cumulated number is ten or more)
- Calibration Compensation: (+/-) 1.0 EV (in 1/10th steps)
- Exposure Compensation: (+/-) 9.9 EV in 1/10 steps)
- Custom Functions: 14
All Weather Feature:
JIS Standard Water Resistance Class 4, Splash Proof Type
- Auto Power Off: Yes, Selectable in Custom Functions
- Battery Power Indicator Display: Icon with 3 status
- Second ISO Film Speed Setting: ISO 3 to 8000 (in 1/3 steps)
- Tripod Socket/Shoe Mount: 1/4 inch - 20 thread mount
- Battery(Power): (1) 3V Battery, Model CR123A Lithium
- Diopter Adjustment: -2.5 to 1.0D
- Operating Temperature Range: 14° to 122° F / -10° to 50° C
- Storage Temperature Range: -4° to 140° F / -20° to 60° C
Radio Triggering Channels:
1 to 16 channels standard, 17 to 32 Quad Triggering
- Radio Triggering Range: Up to 100 feet from transmitter to receiver
Radio Wave Frequency Europe:
Radio Wave Frequency USA Canada:
CH17-CH32 346.50 - 354.00MHz
6.70x3.80x1.90 in./17.00x9.70x4.80 cm
- Product Weight: 0.60lbs./0.30kg.
- Sekonic L-758DR Flash Meter
- L-758 Case
- CR123A Lithium Battery
- Lens cap
- USB cable
- Syncro terminal cap
- Sticker for multi-key and CS Operations
- Software in CD-ROM
- Quick Guide
- Operating Manual


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Legionella is a genus of bacteria known for causing Legionnaires’ disease, a severe form of pneumonia in humans. The Legionella pneumophila species is the primary culprit responsible for this disease. To prevent outbreaks and safeguard public health, it is crucial to employ various diagnostic tests to detect Legionella bacteria in water systems. In this comprehensive article, we explore the different methods available for Legionella testing.
- Legionnaires’ Disease is a severe form of pneumonia caused by Legionella pneumophila, often contracted by inhaling contaminated water droplets from various water systems.
- Legionella culture, a historical gold standard, involves isolating and growing Legionella bacteria, but it is time-consuming.
- Polymerase chain reaction (PCR) offers rapid and sensitive Legionella detection.
- Environmental sampling assesses Legionella risk from various water sources and systems, requiring frequent monitoring.
- There are also tests that can be done on people who suspect they have Legionnaires’ disease, such as respiratory tests, urinary antigen testing and serological testing
Legionnaires’ Disease: A Lethal Threat
Legionella, a type of bacteria, specifically the Legionella pneumophila serogroup, is responsible for causing Legionnaires disease, a severe form of pneumonia. This disease primarily affects people who inhale contaminated water droplets, often originating from hot water systems, cold water systems, or other water sources.
Symptoms of Legionnaires’ disease include flu-like symptoms and severe pneumonia, posing a particular risk to individuals with chronic lung disease. Rapid and accurate diagnosis of Legionnaires’ disease is crucial, especially in the context of disease outbreaks, which can have serious implications for public health.
Testing For Legionella In Water Samples
Testing for Legionella in water samples is a crucial process to ensure the safety of water systems. Utilizing laboratory tests, this assessment evaluates the presence of Legionella bacteria, especially in water containing organic matter, which may generate contaminated droplets of water, posing a potential risk to public health. Below are some Legionella detection methods when observing water samples.
The Gold Standard: Legionella Culture
Historically considered the gold standard for diagnosis, Legionella culture involves isolating and growing Legionella bacteria from water samples. Culture-based methods can be used to identify the presence of L. pneumophila and other Legionella species in water systems. However, it requires specialized laboratory facilities and can take up to 10-14 days for laboratory testing results, making it less suitable for rapid diagnosis.
Polymerase Chain Reaction (PCR) for Legionella Detection
PCR is a molecular biology technique used to detect Legionella DNA in water samples. Real-time PCR allows for the rapid identification of Legionella species, including L. pneumophila. It provides sensitive and specific results, making it a valuable tool for Legionella risk assessments.
Environmental Sampling and Testing
To assess the risk of Legionella growth in water systems, environmental samples are collected from potential sources of contamination. These may include water sources, plumbing systems, cooling towers, evaporative condensers, and stagnant water. Frequent sampling and monitoring are essential to identify potential risk situations.
Challenges of Legionella Tests
- Proper Specimen Collection: Improper collection of specimens, such as sputum or bronchoalveolar lavage (BAL) samples, can affect the sensitivity of Legionella testing.
- Cross-Reactions: Cross-reactions with other bacteria can occur in some diagnostic tests, leading to false positives.
- Legionella Sampling Frequency: Frequent sampling and testing, especially in high-risk situations or seasonal patterns, can help prevent Legionella outbreaks.
- Improper Specimen Collection: Inadequate collection techniques can lead to suboptimal results in Legionella testing, requiring careful attention to collection protocols.
- Limited 16S Sequencing Confirmation: 16S sequencing, a molecular technique for bacterial identification, may not always provide sufficient confirmation for Legionella species.
- Clinical Samples Variability: Variability in clinical samples can make Legionella detection challenging, as the concentration of bacteria may vary between patients or situations.
- Sample for Culture: The choice of sample for culture-based testing can affect the ability to isolate and identify Legionella bacteria, potentially leading to false negatives.
- Culture-Based Testing Complexity: Culture-based methods for Legionella testing can be complex and time-consuming, requiring specialized laboratory equipment and trained personnel.
Testing For Legionnaires Disease In Patients
Unfortunately, in some cases, such as an outbreak situation, it may be too late to take samples of water, as the onset of symptoms are already manifesting in people. In this case, it is essential to carry out tests on people to detect if they are suffering from Legionnaires’ disease.
Urinary Antigen Testing
Urinary antigen tests detect Legionella pneumophila antigen in urine samples from patients with Legionnaires’ disease. This method offers quick results, typically within 15 minutes, and has a high sensitivity and specificity for L. pneumophila serogroup 1, the most common cause of the disease.
Serological Testing for Legionella
This method involves testing a patient’s blood serum for antibodies against Legionella bacteria. While it can indicate exposure to Legionella, serological tests are less useful for the rapid diagnosis of acute infections due to the time it takes for antibody levels to rise.
Respiratory specimens play a vital role in the diagnosis of Legionnaires’ disease in patients. When individuals exhibit symptoms suggestive of the disease, such as severe pneumonia, obtaining respiratory samples such as sputum samples or bronchoalveolar lavage (BAL) samples is essential. These specimens are carefully collected and analyzed for the presence of Legionella bacteria.
Legionella Risk Assessment Services
If you suspect Legionella contamination, seeking professional services immediately is paramount. Legionella Risk and PAT provides comprehensive Legionella risk assessment services to ensure the safety of your water systems. Our expert assessment involves thorough evaluations of water sources, plumbing systems, and potential Legionella contamination points. By identifying and mitigating risks associated with Legionella bacteria growth, we help clients maintain water systems that meet safety standards and reduce the likelihood of Legionnaires’ disease outbreaks.
Frequently Asked Questions
Anyone responsible for managing or maintaining water systems, including building owners, facility managers, and healthcare institutions, should consider Legionella testing to assess the risk of contamination.
The frequency of Legionella testing varies depending on factors like the type of water system, risk assessment, and regulatory requirements. It is typically recommended at regular intervals and during specific situations like outbreaks or system modifications.
Legionella-contaminated water systems can lead to outbreaks of Legionnaires’ disease, affecting individuals with weakened immune systems or underlying health conditions more severely.

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